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Search of human proteins with 164519136
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
(758 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 1562 0.0
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 1498 0.0
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 1498 0.0
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 1498 0.0
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 987 0.0
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 985 0.0
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 984 0.0
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 984 0.0
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 567 e-161
gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 533 e-151
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 472 e-133
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 351 1e-96
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 32 2.2
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 32 2.2
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 32 2.9
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 32 2.9
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 31 4.9
gi|154744870 zinc finger protein 574 [Homo sapiens] 30 6.4
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 30 8.3
gi|50345831 forkhead box J3 [Homo sapiens] 30 8.3
>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
Length = 758
Score = 1562 bits (4044), Expect = 0.0
Identities = 758/758 (100%), Positives = 758/758 (100%)
Query: 1 MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVL 60
MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVL
Sbjct: 1 MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVL 60
Query: 61 VVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGG 120
VVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGG
Sbjct: 61 VVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGG 120
Query: 121 WIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIE 180
WIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIE
Sbjct: 121 WIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIE 180
Query: 181 ELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNV 240
ELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNV
Sbjct: 181 ELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNV 240
Query: 241 IQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFET 300
IQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFET
Sbjct: 241 IQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFET 300
Query: 301 ALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDK 360
ALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDK
Sbjct: 301 ALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDK 360
Query: 361 EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW 420
EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW
Sbjct: 361 EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW 420
Query: 421 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS 480
KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
Sbjct: 421 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS 480
Query: 481 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA 540
AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA
Sbjct: 481 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA 540
Query: 541 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHA 600
PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHA
Sbjct: 541 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHA 600
Query: 601 FDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADN 660
FDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADN
Sbjct: 601 FDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADN 660
Query: 661 GGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPH 720
GGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPH
Sbjct: 661 GGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPH 720
Query: 721 SPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
SPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Sbjct: 721 SPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
sapiens]
Length = 767
Score = 1498 bits (3878), Expect = 0.0
Identities = 727/729 (99%), Positives = 727/729 (99%)
Query: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 89
P LQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS
Sbjct: 39 PNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 98
Query: 90 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 149
EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK
Sbjct: 99 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 158
Query: 150 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 209
HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ
Sbjct: 159 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 218
Query: 210 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 269
DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY
Sbjct: 219 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 278
Query: 270 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 329
LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT
Sbjct: 279 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 338
Query: 330 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 389
LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK
Sbjct: 339 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 398
Query: 390 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 449
TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK
Sbjct: 399 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 458
Query: 450 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 509
SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN
Sbjct: 459 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 518
Query: 510 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 569
DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG
Sbjct: 519 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 578
Query: 570 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 629
ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ
Sbjct: 579 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 638
Query: 630 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 689
TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT
Sbjct: 639 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 698
Query: 690 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 749
NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM
Sbjct: 699 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 758
Query: 750 NPPHKCEVW 758
NPPHKCEVW
Sbjct: 759 NPPHKCEVW 767
>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
sapiens]
Length = 754
Score = 1498 bits (3878), Expect = 0.0
Identities = 727/729 (99%), Positives = 727/729 (99%)
Query: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 89
P LQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS
Sbjct: 26 PNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 85
Query: 90 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 149
EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK
Sbjct: 86 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 145
Query: 150 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 209
HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ
Sbjct: 146 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 205
Query: 210 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 269
DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY
Sbjct: 206 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 265
Query: 270 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 329
LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT
Sbjct: 266 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 325
Query: 330 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 389
LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK
Sbjct: 326 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 385
Query: 390 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 449
TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK
Sbjct: 386 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 445
Query: 450 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 509
SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN
Sbjct: 446 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 505
Query: 510 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 569
DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG
Sbjct: 506 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 565
Query: 570 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 629
ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ
Sbjct: 566 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 625
Query: 630 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 689
TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT
Sbjct: 626 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 685
Query: 690 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 749
NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM
Sbjct: 686 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 745
Query: 750 NPPHKCEVW 758
NPPHKCEVW
Sbjct: 746 NPPHKCEVW 754
>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
Length = 770
Score = 1498 bits (3878), Expect = 0.0
Identities = 727/729 (99%), Positives = 727/729 (99%)
Query: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 89
P LQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS
Sbjct: 42 PNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 101
Query: 90 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 149
EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK
Sbjct: 102 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 161
Query: 150 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 209
HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ
Sbjct: 162 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 221
Query: 210 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 269
DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY
Sbjct: 222 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 281
Query: 270 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 329
LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT
Sbjct: 282 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 341
Query: 330 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 389
LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK
Sbjct: 342 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 401
Query: 390 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 449
TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK
Sbjct: 402 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 461
Query: 450 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 509
SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN
Sbjct: 462 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 521
Query: 510 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 569
DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG
Sbjct: 522 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 581
Query: 570 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 629
ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ
Sbjct: 582 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 641
Query: 630 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 689
TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT
Sbjct: 642 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 701
Query: 690 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 749
NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM
Sbjct: 702 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 761
Query: 750 NPPHKCEVW 758
NPPHKCEVW
Sbjct: 762 NPPHKCEVW 770
>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
sapiens]
Length = 765
Score = 987 bits (2551), Expect = 0.0
Identities = 465/731 (63%), Positives = 586/731 (80%), Gaps = 5/731 (0%)
Query: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCL 88
P +++V F + ++ +RTQ+E L +LLAA L+ CL ALG+QY + S S CL
Sbjct: 38 PDAMEVGFQ--KGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCL 95
Query: 89 SEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAII 148
+EAC+ V IL S+D V PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+
Sbjct: 96 TEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAIL 155
Query: 149 KHLLENSTA-SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDN 207
KHLLEN+T S SEAE+K Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DN
Sbjct: 156 KHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDN 215
Query: 208 FQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLT 267
F + L+ V YR +PFF+VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT
Sbjct: 216 FMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLT 275
Query: 268 GYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAEL 327
YL+YM +LG LLGG R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +EL
Sbjct: 276 AYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL 334
Query: 328 QTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLV 387
Q LAP+++WL FL+ + P+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV
Sbjct: 335 QALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLV 394
Query: 388 RKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAED 447
+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF
Sbjct: 395 QKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQ 454
Query: 448 SKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKV 507
SK IA +I EI+ AFEE+L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V
Sbjct: 455 SKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDV 514
Query: 508 FNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFP 567
++ Y D +F+N + +NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFP
Sbjct: 515 YDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFP 574
Query: 568 AGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFK 627
AGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+
Sbjct: 575 AGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFR 634
Query: 628 RQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLG 687
T CM EQY+ Y VNGE +NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +G
Sbjct: 635 NHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVG 694
Query: 688 LTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGS 747
LTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GS
Sbjct: 695 LTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGS 754
Query: 748 PMNPPHKCEVW 758
PMNP CEVW
Sbjct: 755 PMNPGQLCEVW 765
>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
sapiens]
Length = 883
Score = 985 bits (2546), Expect = 0.0
Identities = 470/748 (62%), Positives = 590/748 (78%), Gaps = 4/748 (0%)
Query: 14 LQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQR-CWAARTQVEKRLVVLVVLLAAGLVACL 72
L G+R P SS + ++ + G R +RTQ+E L +LLAA L+ CL
Sbjct: 137 LAGERDPWTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCL 196
Query: 73 AALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGH 131
ALG+QY + S S CL+EAC+ V IL S+D V PC DF+ ++CGGWI+ NP+PDG
Sbjct: 197 VALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGR 256
Query: 132 SRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKAQVYYRACMNETRIEELRAKPLMEL 190
SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K Q +Y +C+ RIEEL A+PL +L
Sbjct: 257 SRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDL 316
Query: 191 IERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGL 250
IE++GGWNITGPW +DNF + L+ V YR +PFF+VY+SADSK+SNSNVIQVDQSGL L
Sbjct: 317 IEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFL 376
Query: 251 PSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQE 310
PSRDYYLN+T NEKVLT YL+YM +LG LLGG R QMQQ+L+ E LANIT+PQ+
Sbjct: 377 PSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLANITVPQD 435
Query: 311 KRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLI 370
+RRDEE IYHK++ +ELQ LAP+++WL FL+ + P+E+++SEP+VVY +YL+Q+S LI
Sbjct: 436 QRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELI 495
Query: 371 NTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENN 430
N T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C+S+T++
Sbjct: 496 NRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDA 555
Query: 431 LGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYN 490
LGFALG +FVKATF SK IA +I EI+ AFEE+L L WMDE+TR++AKEKADAIY+
Sbjct: 556 LGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYD 615
Query: 491 MIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTP 550
MIG+P+FI++PKELD V++ Y D +F+N + +NFS +V ADQLRK P+RDQWSMTP
Sbjct: 616 MIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTP 675
Query: 551 PMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDK 610
VNAYY PTKNEIVFPAGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDDQGREYDK
Sbjct: 676 QTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDK 735
Query: 611 DGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY 670
+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE +NGR TLGENIADNGGLKAAY AY
Sbjct: 736 EGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAY 795
Query: 671 QNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGS 730
+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+RFRV+G+
Sbjct: 796 KAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGT 855
Query: 731 LSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
LSNS++F HF CP GSPMNP CEVW
Sbjct: 856 LSNSRDFLRHFGCPVGSPMNPGQLCEVW 883
>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
sapiens]
Length = 811
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 49 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 107
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 101 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 160
Query: 108 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 166
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 161 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 220
Query: 167 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 226
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 221 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 280
Query: 227 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 286
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 281 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 340
Query: 287 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 346
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 341 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 399
Query: 347 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 406
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 400 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 459
Query: 407 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 466
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 460 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 519
Query: 467 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 526
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 520 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 579
Query: 527 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 586
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 580 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 639
Query: 587 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 646
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 640 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 699
Query: 647 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 706
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 700 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 759
Query: 707 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 760 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811
>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
Length = 736
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 49 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 107
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
Query: 108 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 166
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
Query: 167 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 226
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Query: 227 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 286
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
Query: 287 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 346
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
Query: 347 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 406
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
Query: 407 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 466
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
Query: 467 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 526
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
Query: 527 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 586
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
Query: 587 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 646
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
Query: 647 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 706
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
Query: 707 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
Length = 779
Score = 567 bits (1461), Expect = e-161
Identities = 281/707 (39%), Positives = 433/707 (61%), Gaps = 29/707 (4%)
Query: 76 GIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWG 135
GI VC + CV + IL +MDPT +PC DF+ +ACGGW++ + +P+ +SR+
Sbjct: 78 GIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYS 137
Query: 136 TFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLG 195
F L + + I+K +LENSTA A KA+ YR+CMN++ IE+ ++PL++++E +G
Sbjct: 138 IFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVG 197
Query: 196 GWNITGPWAKDNFQDT----------LQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 245
GW P A D + +T L ++ + + +++ D +NS+ ++I +DQ
Sbjct: 198 GW----PVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQ 253
Query: 246 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFET 300
LG+PSR+YY N N KV YL +MV + LL D ++ M Q+L+ ET
Sbjct: 254 PTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELET 313
Query: 301 ALANITIPQEKRRDEELIYHKVTAAELQTL--APAINWLPFLNTIFYPVEIN--ESEPIV 356
LA T+PQE+R D +YH++ ELQ+ NW F+ T+ V+I E +V
Sbjct: 314 QLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVV 373
Query: 357 VYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC 416
VY YL+ + +I+T + NY++W LV L QRF+D + + ++GT
Sbjct: 374 VYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEE 433
Query: 417 LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEE 476
+ RW+ CV +N+ A+G ++V+ F DSKS+ E+I +++ F E+L L WMDEE
Sbjct: 434 V-RWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEE 492
Query: 477 TRKSAKEKADAIYNMIGYPNFIMDP--KELDKVFNDYTAVPDLYFENAMRFFNFSWRVTA 534
++K A+EKA +I IG+P++I++ + LD+ +++ DLYFEN+++ + +
Sbjct: 493 SKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSL 552
Query: 535 DQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVG 594
+LR+ + + W + +VNA+YSP +N+IVFPAGILQ PF+++ P+ALNFGGIG+V+G
Sbjct: 553 RKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIG 612
Query: 595 HELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRH 651
HE+TH FDD GR +DK+GN+ WW N S + F+ Q+ECM+ QY NYS + + VNG +
Sbjct: 613 HEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFN 672
Query: 652 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS 711
TLGENIADNGG++ AY+AY W+ + G + LP L LT+ QLFF+ +AQVWC PE +
Sbjct: 673 TLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFA 732
Query: 712 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
+ + TD HSP ++RV+GSL N F++ F C G+PM+P +C VW
Sbjct: 733 IQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779
>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 35 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 94
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 95 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 154
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 155 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 208
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 209 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 268
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 269 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 323
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 324 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 375
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 376 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 435
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 436 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 495
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 496 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 554
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 555 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 614
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 615 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 671
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 672 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 731
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 732 SNSKEFSEHFRCPPGSPMNPPHKCEVW 758
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 35 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 94
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 95 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 154
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 155 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 208
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 209 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 268
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 269 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 323
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 324 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 375
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 376 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 435
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 436 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 495
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 496 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 554
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 555 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 614
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 615 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 671
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 672 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 731
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 732 SNSKEFSEHFRCPPGSPMNPPHKCEVW 758
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 35 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 94
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 95 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 154
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 155 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 208
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 209 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 268
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 269 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 323
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 324 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 375
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 376 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 435
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 436 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 495
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 496 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 554
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 555 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 614
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 615 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 671
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 672 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 731
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 732 SNSKEFSEHFRCPPGSPMNPPHKCEVW 758
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 35 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 94
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 95 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 154
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 155 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 208
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 209 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 268
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 269 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 323
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 324 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 375
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 376 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 435
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 436 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 495
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 496 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 554
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 555 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 614
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 615 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 671
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 672 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 731
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 732 SNSKEFSEHFRCPPGSPMNPPHKCEVW 758
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 533 bits (1373), Expect = e-151
Identities = 281/749 (37%), Positives = 434/749 (57%), Gaps = 25/749 (3%)
Query: 29 LPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA-LGIQYQT------ 81
LPP + +G R R + ++ ++ AAGL A LAA L ++Y
Sbjct: 33 LPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGG 92
Query: 82 -RSPSVCLSEACVSVTSSILSS-MDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSN 139
P C + + L++ +D ++DPC DF+S+ACGGW++ + +PD +GT +
Sbjct: 93 GACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAA 152
Query: 140 LWEHNQAIIKHLLENSTASVS-EAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWN 198
+ E N+ ++ LL A+RK + ++R+C++ IE L +P++E+IE GGW+
Sbjct: 153 IGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWD 212
Query: 199 ITGPW------AKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS 252
+ G A+ + L Y + FS+ VS D +NS+ VI++DQ GL LP
Sbjct: 213 LGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE 272
Query: 253 RDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQ-- 309
R YL + E+ EK+L Y +M ++ LLG +A+ + Q+IL E LANIT+ +
Sbjct: 273 RTLYLAQDEDSEKILAAYRVFMERVLSLLGA---DAVEQKAQEILQVEQQLANITVSEHD 329
Query: 310 EKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTL 369
+ RRD +Y+KVT +LQ + P + W L+ IF + +E E +V+ +Y++Q+S L
Sbjct: 330 DLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQL 388
Query: 370 INTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTEN 429
I +T +L+NY++W +V S L F++A + + M G+ K + C+
Sbjct: 389 IRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKP-QELARVCLGQANR 447
Query: 430 NLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIY 489
+ G ALG +FV F+ SK+ +++ +IK + L L WMD ETR +A+ K +
Sbjct: 448 HFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMM 507
Query: 490 NMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMT 549
M+GYP+F++ P +DK + ++ YF+N + FS +++ ++R+ ++ W +
Sbjct: 508 VMVGYPDFLLKPDAVDKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLP 566
Query: 550 PPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYD 609
P +NAYY P KN++VFPAGILQ Y P++LN+GGIG ++GHELTH +DD G +YD
Sbjct: 567 PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYD 626
Query: 610 KDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRA 669
+ GNL WW +S F R+ EC+V Y N++V + VNG+HTLGENIAD GGLK AY A
Sbjct: 627 RSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHA 686
Query: 670 YQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIG 729
YQ WV+++G EH LP L T++QLFF+ FAQ WC R +S + ++TD H+P +RV+G
Sbjct: 687 YQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLG 746
Query: 730 SLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
S+S +EF F CP SPMNP HKC VW
Sbjct: 747 SVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775
>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
Length = 749
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 64 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 123
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
Query: 124 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 181
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
Query: 182 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 231
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
Query: 232 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 290
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
Query: 291 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 346
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
Query: 347 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 404
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
Query: 405 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 464
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
Query: 465 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 523
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
Query: 524 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 582
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
Query: 583 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 640
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
Query: 641 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 697
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
Query: 698 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 756
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
Query: 757 VW 758
+W
Sbjct: 748 LW 749
>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
Length = 732
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 40 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 98
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
Query: 99 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 157
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
Query: 158 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 217
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
Query: 218 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 273
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Query: 274 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 333
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
Query: 334 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 390
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
Query: 391 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 446
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
Query: 447 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 506
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
Query: 507 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 566
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
Query: 567 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 626
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
Query: 627 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 685
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
Query: 686 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 745
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
Query: 746 GSPMNPPHKCEVW 758
G+ +NP +C++W
Sbjct: 720 GALLNPSSRCQLW 732
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/39 (38%), Positives = 22/39 (56%)
Query: 439 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 477
+ + TFA S TE +LEI +A + T KW+D+ T
Sbjct: 2192 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2230
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/39 (38%), Positives = 22/39 (56%)
Query: 439 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 477
+ + TFA S TE +LEI +A + T KW+D+ T
Sbjct: 2171 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2209
>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
isoform 2 [Homo sapiens]
Length = 829
Score = 31.6 bits (70), Expect = 2.9
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%)
Query: 394 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 453
L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT
Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93
Query: 454 -------EIILEIKKAFEESLSTLKWMDEET 477
E I E+K+ + E +++L+ + +ET
Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124
>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
1 [Homo sapiens]
Length = 862
Score = 31.6 bits (70), Expect = 2.9
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%)
Query: 394 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 453
L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT
Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93
Query: 454 -------EIILEIKKAFEESLSTLKWMDEET 477
E I E+K+ + E +++L+ + +ET
Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 30.8 bits (68), Expect = 4.9
Identities = 15/41 (36%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 446 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 486
++S+S++TE+ +IK A+EESL L+ + E + +E +D
Sbjct: 1476 KESRSLSTELF-KIKNAYEESLDQLETLKRENKNLQQEISD 1515
>gi|154744870 zinc finger protein 574 [Homo sapiens]
Length = 896
Score = 30.4 bits (67), Expect = 6.4
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 7/65 (10%)
Query: 128 PDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPL 187
PD + +FSNLW+H K + A+V + +A+ + ET +E L PL
Sbjct: 825 PDCGKSYRSFSNLWKHR----KTHQQQHQAAVRQQLAEAEAAVGLAVMETAVEAL---PL 877
Query: 188 MELIE 192
+E IE
Sbjct: 878 VEAIE 882
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 30.0 bits (66), Expect = 8.3
Identities = 14/41 (34%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 446 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 486
++S+S++TE+ ++K A+EESL L+ + E + +E +D
Sbjct: 1476 KESRSLSTELF-KVKNAYEESLDHLETLKRENKNLQQEISD 1515
>gi|50345831 forkhead box J3 [Homo sapiens]
Length = 622
Score = 30.0 bits (66), Expect = 8.3
Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 4/49 (8%)
Query: 457 LEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNM----IGYPNFIMDP 501
L + E SL+++ W+ + T ++A +K+DA N I N ++DP
Sbjct: 14 LRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDP 62
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,348,178
Number of Sequences: 37866
Number of extensions: 1390639
Number of successful extensions: 3687
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3594
Number of HSP's gapped (non-prelim): 29
length of query: 758
length of database: 18,247,518
effective HSP length: 110
effective length of query: 648
effective length of database: 14,082,258
effective search space: 9125303184
effective search space used: 9125303184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.