Search of human proteins with 16418425

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16418425 guanylate-binding protein 5 [Homo sapiens]
         (586 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197333737 guanylate-binding protein 5 [Homo sapiens]              1160   0.0  
gi|16418425 guanylate-binding protein 5 [Homo sapiens]               1160   0.0  
gi|166706903 guanylate binding protein 1, interferon-inducible, ...   774   0.0  
gi|112382372 guanylate binding protein 3 [Homo sapiens]               772   0.0  
gi|38327558 guanylate binding protein 2, interferon-inducible [H...   738   0.0  
gi|148234215 guanylate binding protein 4-like [Homo sapiens]          593   e-169
gi|31377634 guanylate binding protein 4 [Homo sapiens]                588   e-168
gi|157671915 guanylate binding protein family, member 6 [Homo sa...   587   e-167
gi|45827806 atlastin 3 [Homo sapiens]                                  83   6e-16
gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [...    77   6e-14
gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens]                72   2e-12
gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens]                72   2e-12
gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens]                68   2e-11
gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens]                 68   2e-11
gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens]                 68   2e-11
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    54   5e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         53   7e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        53   7e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        53   7e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         53   7e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         53   7e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         53   7e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         53   7e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         53   7e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         53   7e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    53   9e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    52   2e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    52   2e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     52   2e-06
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   51   3e-06

>gi|197333737 guanylate-binding protein 5 [Homo sapiens]
          Length = 586

 Score = 1160 bits (3000), Expect = 0.0
 Identities = 586/586 (100%), Positives = 586/586 (100%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
Sbjct: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
           LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180

Query: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
           RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240

Query: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
           HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN
Sbjct: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300

Query: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
           AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER
Sbjct: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360

Query: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
           EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV
Sbjct: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420

Query: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
           KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL
Sbjct: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480

Query: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ 540
           TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ
Sbjct: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ 540

Query: 541 QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 586
           QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
Sbjct: 541 QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 586


>gi|16418425 guanylate-binding protein 5 [Homo sapiens]
          Length = 586

 Score = 1160 bits (3000), Expect = 0.0
 Identities = 586/586 (100%), Positives = 586/586 (100%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
Sbjct: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
           LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180

Query: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
           RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240

Query: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
           HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN
Sbjct: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300

Query: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
           AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER
Sbjct: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360

Query: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
           EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV
Sbjct: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420

Query: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
           KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL
Sbjct: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480

Query: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ 540
           TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ
Sbjct: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ 540

Query: 541 QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 586
           QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
Sbjct: 541 QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL 586


>gi|166706903 guanylate binding protein 1, interferon-inducible,
           67kDa [Homo sapiens]
          Length = 592

 Score =  774 bits (1999), Expect = 0.0
 Identities = 396/591 (67%), Positives = 474/591 (80%), Gaps = 6/591 (1%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MA EIHM+ PMCLIEN N +L  N EAL+ILSAITQP+VVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           K KGFS+ STVQSHTKGIW+WCVPHP  P H LVLLDTEGLGDVEK DN+ND  IFALA+
Sbjct: 61  KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDR--VEDPADSASFFPDLVW 178
           LLSSTFVYN++  I+Q A+D L+ VTELT  +++++SPD +   VED AD  SFFPD VW
Sbjct: 121 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW 180

Query: 179 TLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDL 238
           TLRDF L LE DGQ +TPDEYL  SL+ K+G+ Q+ + FNLPRLCI+KFFPKKKCF+FD 
Sbjct: 181 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR 240

Query: 239 PAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTY 298
           P H++KLAQLE L D+EL+PEFVQQV +FCSYIFS+S TKTL GGI VNG RL++LVLTY
Sbjct: 241 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY 300

Query: 299 VNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTS 358
           VNAISSGDLPC+ENAVLALAQ ENSAAVQKAIAHY+QQMGQKVQLP ETLQELLDLHR S
Sbjct: 301 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDS 360

Query: 359 EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE 418
           EREAIEVF+++SFKDVD  FQKEL   L+ K++D CK+N EASSD CSALL+ IF PLEE
Sbjct: 361 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEE 420

Query: 419 AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQ 478
            VK GIYSKPGG+ LF+QK ++LK KYY EPRKGIQAEE+LQ YLKSKES++ AILQTDQ
Sbjct: 421 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ 480

Query: 479 ALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQ 534
            LTE EK+ +  +VKAE+ +A A+ L  +QR+NEQMM+++ER +QE ++Q    ME  + 
Sbjct: 481 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV 540

Query: 535 NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVL 585
             L EQ++    ++QEQ   L   FQ ++R + +E+Q  Q  +     C +
Sbjct: 541 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTI 591


>gi|112382372 guanylate binding protein 3 [Homo sapiens]
          Length = 595

 Score =  772 bits (1994), Expect = 0.0
 Identities = 396/581 (68%), Positives = 469/581 (80%), Gaps = 4/581 (0%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MA EIHM+ PMCLIEN N +L  N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           KNKGFS+ STV+SHTKGIW+WCVPHP  P HTLVLLDTEGLGDV+K DN+ND  IF LA+
Sbjct: 61  KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
           LLSST VYN++  I+Q A+D L+ VTELT  +++++SPD +  ED AD  SFFPD VWTL
Sbjct: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180

Query: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
           RDF L LE DGQ +TPDEYLE SL+  QG+ Q+ +NFNLPRLCI+KFFPKKKCF+FDLP 
Sbjct: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240

Query: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
           H++KLAQLE L D+EL+PEFVQQV +FCSYIFS+S TKTL GGI VNG RL++LVLTY+N
Sbjct: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300

Query: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
           AIS GDLPC+ENAVLALAQ ENSAAVQKAIAHYDQQMGQKVQLP ETLQELLDLHR SER
Sbjct: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360

Query: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
           EA EV+MKNSFKDVD  FQK+L   LD K++D CK+N EASSD CSALL+ IF PLEE V
Sbjct: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420

Query: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
           K GIYSKPGG+ LFIQK ++L+ KYY EPRKGIQAEE+LQ YLKSKESV+ AILQTDQ L
Sbjct: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480

Query: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQNW 536
           TE EK+ +   VKAE+ +A A+ +  +Q + +QMM+E+E+ +QE V+Q    ME  +   
Sbjct: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540

Query: 537 LAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
           L EQ+K    ++QEQA  L    Q ++  L +E+Q  Q+T+
Sbjct: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTL 581


>gi|38327558 guanylate binding protein 2, interferon-inducible [Homo
           sapiens]
          Length = 591

 Score =  738 bits (1904), Expect = 0.0
 Identities = 375/586 (63%), Positives = 467/586 (79%), Gaps = 4/586 (0%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MA EI++  PM LI+N   QL VN EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           K  GFS+ STV+SHTKGIW+WCVPHP  P HTLVLLDTEGLGD+EK DN+ND  IFALA+
Sbjct: 61  KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
           LLSSTFVYN++  I+Q A+D LH VTELTD +KA +SP  + V+D AD  SFFP  VWTL
Sbjct: 121 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL 180

Query: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
           RDF L LE+DG+ +T D+YLE SL+ ++G+D++ ++FN PRLCI+KFFPK+KCF+FD PA
Sbjct: 181 RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA 240

Query: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
            +K LA LE L ++EL P+F++QV EFCSYI SHS  KTL GGI VNG RL++LVLTYVN
Sbjct: 241 PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN 300

Query: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
           AISSGDLPC+ENAVLALAQ ENSAAV+KAIAHY+QQMGQKVQLP ETLQELLDLHR SER
Sbjct: 301 AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER 360

Query: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
           EAIEVFMKNSFKDVDQ FQ++L   L+A+++D CK+N +ASSD C ALL+DIFGPLEE V
Sbjct: 361 EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV 420

Query: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
           KQG +SKPGG+ LF QK +ELK KYY+ PRKGIQA+EVL+KYL+SKE V+ A+LQTDQ+L
Sbjct: 421 KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL 480

Query: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQNW 536
           +E EK  +  ++KAE+ +A  + L  IQ++NE+MM+++E+ +QE V+Q    ME  +   
Sbjct: 481 SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL 540

Query: 537 LAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDP 582
           +AEQ+K    ++QEQ   L   F+ +++ L  ++   Q    + +P
Sbjct: 541 MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEP 586


>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
          Length = 638

 Score =  593 bits (1529), Expect = e-169
 Identities = 307/592 (51%), Positives = 415/592 (70%), Gaps = 8/592 (1%)

Query: 1   MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
           MA EIHM  P+CL EN    L VN EALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1   MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60

Query: 61  KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
           KNKGF +  TV+S TKGIW+WCVPHP+ PNHTL+LLDTEGLGD+EK+D K+D  IFALA+
Sbjct: 61  KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120

Query: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
           LLSS+FVYN++  I+  A++ LH VTELT+L++A++ P  D VED ++  SFFPD +WT+
Sbjct: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180

Query: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
           RDF L L++DG  +T DEYLEN+L+   G + ++QN N PR  I+ FFPK+KCF+FD P 
Sbjct: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240

Query: 241 HQKK-LAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYV 299
           + KK L  +E + +D+L+  F  Q   FCSYIF+H+ TKTL  GI+V G+RL  LV TY+
Sbjct: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300

Query: 300 NAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE 359
           +AI+SG  PC+ENA+  LAQ ENSAAVQ+A  HY QQM Q+V+ P +TLQELLD+H   E
Sbjct: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360

Query: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419
           REAI VFM+ SFKD  Q FQK+L   ++ K+ D   +N EAS+ YC A LK +   L E+
Sbjct: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420

Query: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479
           + +G +  PGGHN++++  ++++  Y   PRKG++A+EVLQ +L+S+  +  +ILQ+D+A
Sbjct: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480

Query: 480 LTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQN 535
           LT  EK     Q K EA + E + L   Q++ +QMM+ +ER  QE + Q    ME  ++N
Sbjct: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540

Query: 536 WLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV---NNDDPCV 584
           ++ E +KM   +M+     L+  F+    SL  E+   +  +    N++P V
Sbjct: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592


>gi|31377634 guanylate binding protein 4 [Homo sapiens]
          Length = 640

 Score =  588 bits (1515), Expect = e-168
 Identities = 298/578 (51%), Positives = 412/578 (71%), Gaps = 5/578 (0%)

Query: 7   MSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
           M  P+CL+EN  EQL VN +ALEIL  I+QPVVVVAIVGLYRTGKSYLMN+LAGK  GF 
Sbjct: 22  MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFP 81

Query: 67  VASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTF 126
           + STVQS TKGIW+WCVPH + PNHTLVLLDTEGLGDVEK++ KND  IFALA+LLSS+F
Sbjct: 82  LGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSF 141

Query: 127 VYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLG 186
           VYN+V+ I+  A++ LH VTEL +L++A++ P  D  ED ++ ASFFPD +WT+RDF L 
Sbjct: 142 VYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201

Query: 187 LEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKK-L 245
           L++DG  +T DEYLEN+L+   G + ++QN N+PR CI+ FF K+KCF+FD P + K+ L
Sbjct: 202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYL 261

Query: 246 AQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSG 305
             ++ +P++ LE  F+ Q   FCSYIF+H+ TKTL  GI+V G RL  LV+TYV+AI+SG
Sbjct: 262 NHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSG 321

Query: 306 DLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEV 365
            +PC+ENAV ALAQ EN AAVQ+A  HY QQM Q+++LP +TLQELLD+H   EREAI V
Sbjct: 322 AVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381

Query: 366 FMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIY 425
           FM++SFKD +  FQK+L   ++ K+ D   +N EAS+ YC A LK +   L E++ +GI+
Sbjct: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441

Query: 426 SKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK 485
           S PGGHNL++++ ++++  Y   PRKG++A EVLQ +L+S+  V  +ILQ+D+ALT  EK
Sbjct: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEK 501

Query: 486 KKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQM----EIAKQNWLAEQQ 541
                +   EA + E + L   Q++ +QMM+ +ER  QE + QM    E  ++N L E +
Sbjct: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561

Query: 542 KMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN 579
           ++ + +++ Q   L   FQ ++  L  E+   +  + +
Sbjct: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIES 599


>gi|157671915 guanylate binding protein family, member 6 [Homo
           sapiens]
          Length = 633

 Score =  587 bits (1513), Expect = e-167
 Identities = 298/583 (51%), Positives = 413/583 (70%), Gaps = 8/583 (1%)

Query: 7   MSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
           M  P+CL+EN NEQL VNQ+A++IL  I+QPVVVVAIVGLYRTGKSYLMN LAG+N GF 
Sbjct: 7   MLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFP 66

Query: 67  VASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTF 126
           + STVQS TKGIW+WCVPHP+ PNHTLVLLDTEGLGDVEK D KND  IFALA+LL STF
Sbjct: 67  LGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTF 126

Query: 127 VYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLG 186
           VYN+++ I+  A++ LH VTELT+L+KA++SP  D VED  +  SFFPD +WT+RDF L 
Sbjct: 127 VYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLE 186

Query: 187 LEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKK-L 245
           L+++G  +T DEYLEN+L+  QG++ RVQ  N PR CI++FFPK+KCF+FD P + K  L
Sbjct: 187 LKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLL 246

Query: 246 AQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSG 305
           A +E + + +L+P+F +Q   FCSYIF+H+ TKTL  GI V G+RL  L +TYV AI+SG
Sbjct: 247 ANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSG 306

Query: 306 DLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEV 365
            +PC+ENAV+ LAQRENSAAVQ+A  +Y QQM Q+V+LP +TLQELLD+H   EREAI +
Sbjct: 307 AVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAI 366

Query: 366 FMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIY 425
           FM++SFKD +Q FQK+       K+ D   +N E+S  YC A L ++   L E++  G +
Sbjct: 367 FMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSF 426

Query: 426 SKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK 485
           S PGGH L+++  E ++  Y++ PRKG++A+EV Q++L+S+  +  +ILQ+D+ALT+ EK
Sbjct: 427 SVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREK 486

Query: 486 KKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQNWLAEQQ 541
                + K EA + E + L    ++ +Q M+ +++  +E + Q    +++ +++ L EQ 
Sbjct: 487 AVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQI 546

Query: 542 KMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR---TVNNDD 581
            M E   + Q   L   F+ +   + +E+   +R   T  NDD
Sbjct: 547 MMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDD 589


>gi|45827806 atlastin 3 [Homo sapiens]
          Length = 541

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 104/399 (26%), Positives = 162/399 (40%), Gaps = 65/399 (16%)

Query: 38  VVVVAIVGLYRTGKSYLMN---------KLAGKNK----------GFSVASTVQSHTKGI 78
           VVVV++ G +R GKS++++         K +G +           GFS        T GI
Sbjct: 60  VVVVSVAGAFRKGKSFILDFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETTGI 119

Query: 79  WIW----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKI 134
            IW     V  P      +VL+DT+G  D  ++  K+   IFAL+ + SS  +YN    I
Sbjct: 120 QIWSEVFTVEKPGGKKVAVVLMDTQGAFD-SQSTVKDCATIFALSTMTSSVQIYNLSQNI 178

Query: 135 DQGAIDLLHNVTELTDLLKARNSPDLDRV-EDPADSASFFPDLVWTLRDFCLGLEIDGQL 193
            +  +  L   TE   L        +D + + P      F  L++ +RD+    E    L
Sbjct: 179 QEDDLQQLQLFTEYGRLA-------MDEIFQKP------FQTLMFLVRDWSFPYEYSYGL 225

Query: 194 VTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD 253
                +L+  L+ K+   + +QN    R  I   F    CF+   P       Q+ T PD
Sbjct: 226 QGGMAFLDKRLQVKEHQHEEIQNV---RNHIHSCFSDVTCFLLPHPG-----LQVATSPD 277

Query: 254 -----DELEPEFVQQVTEFCSYIFSHS--MTKTLPGGIMVNGSRLKNLVLTYVNAISSGD 306
                 ++  EF +Q+     Y+ + S  M K +  G  V    L      Y+      D
Sbjct: 278 FDGKLKDIAGEFKEQLQALIPYVLNPSKLMEKEI-NGSKVTCRGLLEYFKAYIKIYQGED 336

Query: 307 LPCIENAVLALAQRENSAAVQKAIAHYDQQM-----GQKVQLPMETLQELLDLHRTSERE 361
           LP  ++ + A A+  N AA   A   Y   M     G+K  L  + L+E    H   ++ 
Sbjct: 337 LPHPKSMLQATAEANNLAAAASAKDIYYNNMEEVCGGEKPYLSPDILEE---KHCEFKQL 393

Query: 362 AIEVFMKN---SFKDVDQSFQKELETLLDAKQNDICKRN 397
           A++ F K      KD    +Q+ELE  +     + CK N
Sbjct: 394 ALDHFKKTKKMGGKDFSFRYQQELEEEIKELYENFCKHN 432


>gi|169160863 PREDICTED: similar to guanylate-binding protein 5
           [Homo sapiens]
          Length = 112

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 38/68 (55%), Positives = 51/68 (75%), Gaps = 1/68 (1%)

Query: 315 LALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDV 374
           + LAQRENS A+Q+A  HY QQM Q+++ P + LQELLD+H   EREAI VFM++S +  
Sbjct: 1   MTLAQRENSVALQRAANHYSQQMAQRMRFPTDMLQELLDMHTACEREAIAVFMEHS-RGE 59

Query: 375 DQSFQKEL 382
           +Q FQK+L
Sbjct: 60  NQEFQKKL 67


>gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens]
          Length = 583

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 92/389 (23%), Positives = 163/389 (41%), Gaps = 48/389 (12%)

Query: 38  VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFSVASTVQSHTKGIWIW 81
           +VVV++ G +R GKS+L+        NK     + G N+   GF+     +  T GI +W
Sbjct: 94  IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153

Query: 82  ----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQG 137
                +  PN     ++L+DT+G  D  ++  K+   +FAL+ + SS  VYN    I + 
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQED 212

Query: 138 AIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPD 197
            +  L   TE   L         +  + P      F  L++ +RD+    E    L    
Sbjct: 213 DLQHLQLFTEYGRLAME------EIYQKP------FQTLMFLIRDWSYPYEHSYGLEGGK 260

Query: 198 EYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD--DE 255
           ++LE  L+ KQ   + +QN    R  I   F    CF+  LP    K+A   +      +
Sbjct: 261 QFLEKRLQVKQNQHEELQNV---RKHIHNCFSNLGCFL--LPHPGLKVATNPSFDGRLKD 315

Query: 256 LEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAV 314
           ++ +F +++      + +  ++ +    G  V    L      Y+      +LP  ++ +
Sbjct: 316 IDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSML 375

Query: 315 LALAQRENSAAVQKAIAHYDQQM-----GQKVQL-PMETLQELLDLHRTSEREAIEVFMK 368
            A A+  N AAV  A   Y + M     G K  + P +  ++ LDL   + ++   V  K
Sbjct: 376 QATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KK 434

Query: 369 NSFKDVDQSFQKELETLLDAKQNDICKRN 397
               +  + +Q +LE  ++    +  K N
Sbjct: 435 MGGDEFCRRYQDQLEAEIEETYANFIKHN 463


>gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens]
          Length = 579

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 92/389 (23%), Positives = 163/389 (41%), Gaps = 48/389 (12%)

Query: 38  VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFSVASTVQSHTKGIWIW 81
           +VVV++ G +R GKS+L+        NK     + G N+   GF+     +  T GI +W
Sbjct: 94  IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153

Query: 82  ----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQG 137
                +  PN     ++L+DT+G  D  ++  K+   +FAL+ + SS  VYN    I + 
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQED 212

Query: 138 AIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPD 197
            +  L   TE   L         +  + P      F  L++ +RD+    E    L    
Sbjct: 213 DLQHLQLFTEYGRLAME------EIYQKP------FQTLMFLIRDWSYPYEHSYGLEGGK 260

Query: 198 EYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD--DE 255
           ++LE  L+ KQ   + +QN    R  I   F    CF+  LP    K+A   +      +
Sbjct: 261 QFLEKRLQVKQNQHEELQNV---RKHIHNCFSNLGCFL--LPHPGLKVATNPSFDGRLKD 315

Query: 256 LEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAV 314
           ++ +F +++      + +  ++ +    G  V    L      Y+      +LP  ++ +
Sbjct: 316 IDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSML 375

Query: 315 LALAQRENSAAVQKAIAHYDQQM-----GQKVQL-PMETLQELLDLHRTSEREAIEVFMK 368
            A A+  N AAV  A   Y + M     G K  + P +  ++ LDL   + ++   V  K
Sbjct: 376 QATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KK 434

Query: 369 NSFKDVDQSFQKELETLLDAKQNDICKRN 397
               +  + +Q +LE  ++    +  K N
Sbjct: 435 MGGDEFCRRYQDQLEAEIEETYANFIKHN 463


>gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens]
          Length = 553

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 52/391 (13%)

Query: 38  VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSVASTVQSHTKGIWIW 81
           VV V++ G +R GKS+LM+ +                N+   GFS     +  T GI IW
Sbjct: 67  VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126

Query: 82  ----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQG 137
                +  P+     ++L+DT+G  D  ++  ++   +FAL+ ++SS  VYN    + + 
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185

Query: 138 AIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPD 197
            +  L   TE              R+         F  L++ +RD+    E         
Sbjct: 186 DLQHLQLFTE------------YGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGA 233

Query: 198 EYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD---- 253
           ++LE  L+      + +QN    R  I   F    CF+   P       ++ T P+    
Sbjct: 234 KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFLLPHPG-----LKVATNPNFDGK 285

Query: 254 -DELEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIE 311
             E++ EF++ +     ++ S  S+      G  +    L      Y+      +LP  +
Sbjct: 286 LKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPK 345

Query: 312 NAVLALAQRENSAAVQKAIAHYDQQMGQKV--QLPMETLQELLDLHRTSEREAIEVF--- 366
           + + A A+  N AAV  A   Y+++M +      P     +L   H   + E++++F   
Sbjct: 346 SMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGV 405

Query: 367 MKNSFKDVDQSFQKELETLLDAKQNDICKRN 397
            K   ++  + + ++LE+ +D       K N
Sbjct: 406 KKMGGEEFSRRYLQQLESEIDELYIQYIKHN 436


>gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens]
          Length = 553

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 52/391 (13%)

Query: 38  VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSVASTVQSHTKGIWIW 81
           VV V++ G +R GKS+LM+ +                N+   GFS     +  T GI IW
Sbjct: 67  VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126

Query: 82  ----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQG 137
                +  P+     ++L+DT+G  D  ++  ++   +FAL+ ++SS  VYN    + + 
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185

Query: 138 AIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPD 197
            +  L   TE              R+         F  L++ +RD+    E         
Sbjct: 186 DLQHLQLFTE------------YGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGA 233

Query: 198 EYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD---- 253
           ++LE  L+      + +QN    R  I   F    CF+   P       ++ T P+    
Sbjct: 234 KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFLLPHPG-----LKVATNPNFDGK 285

Query: 254 -DELEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIE 311
             E++ EF++ +     ++ S  S+      G  +    L      Y+      +LP  +
Sbjct: 286 LKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPK 345

Query: 312 NAVLALAQRENSAAVQKAIAHYDQQMGQKV--QLPMETLQELLDLHRTSEREAIEVF--- 366
           + + A A+  N AAV  A   Y+++M +      P     +L   H   + E++++F   
Sbjct: 346 SMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGV 405

Query: 367 MKNSFKDVDQSFQKELETLLDAKQNDICKRN 397
            K   ++  + + ++LE+ +D       K N
Sbjct: 406 KKMGGEEFSRRYLQQLESEIDELYIQYIKHN 436


>gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens]
          Length = 558

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 85/391 (21%), Positives = 157/391 (40%), Gaps = 52/391 (13%)

Query: 38  VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSVASTVQSHTKGIWIW 81
           VV V++ G +R GKS+LM+ +                N+   GFS     +  T GI IW
Sbjct: 67  VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126

Query: 82  ----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQG 137
                +  P+     ++L+DT+G  D  ++  ++   +FAL+ ++SS  VYN    + + 
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185

Query: 138 AIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPD 197
            +  L   TE              R+         F  L++ +RD+    E         
Sbjct: 186 DLQHLQLFTE------------YGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGA 233

Query: 198 EYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD---- 253
           ++LE  L+      + +QN    R  I   F    CF+   P       ++ T P+    
Sbjct: 234 KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFLLPHPG-----LKVATNPNFDGK 285

Query: 254 -DELEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIE 311
             E++ EF++ +     ++ S  S+      G  +    L      Y+      +LP  +
Sbjct: 286 LKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPK 345

Query: 312 NAVLALAQRENSAAVQKAIAHYDQQMGQKV--QLPMETLQELLDLHRTSEREAIEVF--- 366
           + + A A+  N AAV  A   Y+++M +      P     +L   H   + E++++F   
Sbjct: 346 SMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGV 405

Query: 367 MKNSFKDVDQSFQKELETLLDAKQNDICKRN 397
            K   ++  + + ++LE+ +D       K N
Sbjct: 406 KKMGGEEFSRRYLQQLESEIDELYIQYIKHN 436


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 30/100 (30%), Positives = 61/100 (61%), Gaps = 2/100 (2%)

Query: 478  QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            Q L + ++ +++ Q++ + ++ + Q+   +Q+Q  Q  Q++++L Q+Q +Q++  +Q  L
Sbjct: 3898 QQLQQQQQLQQQQQLQQQQQQ-QLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQ-QQQQQL 3955

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             +QQ+ Q+QQ Q+Q  Q       Q+R+LLS  Q  Q+ V
Sbjct: 3956 QQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQV 3995



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/186 (21%), Positives = 83/186 (44%), Gaps = 13/186 (6%)

Query: 412  IFGPLEEAVKQ----GIYSKPGGHN-LFIQKTEELKAKYYREPRKGIQ------AEEVLQ 460
            + GP + AV Q    G     G H  + + ++  L +    +  +G+       A++  Q
Sbjct: 3801 MLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQ 3860

Query: 461  KYLKSKESVSHAILQTDQAL-TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERE 519
            +    ++     +    Q+L + + + K  AQ     ++ + Q+    Q+Q  Q  Q+++
Sbjct: 3861 QQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQ-QQQQLQQQQQQQ 3919

Query: 520  RLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN 579
               Q+Q++Q ++ +Q    + Q+ Q+QQ+Q+Q  QL    Q Q +    + Q  Q  + N
Sbjct: 3920 LQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLN 3979

Query: 580  DDPCVL 585
                +L
Sbjct: 3980 QSRTLL 3985



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 28/117 (23%), Positives = 64/117 (54%), Gaps = 5/117 (4%)

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMM 515
            +++LQ  LK  E       ++ +AL   ++  K+A    E  +A+A++L  +  Q  ++ 
Sbjct: 3518 QQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAG--REFPEADAEKLKLVTEQQSKIQ 3575

Query: 516  QERERLHQEQVRQMEIAKQ--NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSEL 570
            ++ +++ ++Q     +  +  N   +QQ+ Q+QQ Q+ +A L+ +  +Q+  LL++L
Sbjct: 3576 KQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALS-PSQSPRLLTKL 3631



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 21/100 (21%), Positives = 52/100 (52%), Gaps = 3/100 (3%)

Query: 453  IQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNE 512
            +Q ++ LQ+  + ++     + Q  Q     +++ ++ Q + + ++ + Q+L   Q+Q +
Sbjct: 3900 LQQQQQLQQQQQLQQQQQQQLQQQQQL---QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQ 3956

Query: 513  QMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQA 552
            Q  Q++++  Q+Q +Q ++   N        Q+QQ Q+ A
Sbjct: 3957 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVA 3996



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 20/90 (22%), Positives = 48/90 (53%), Gaps = 3/90 (3%)

Query: 475  QTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQ 534
            Q  Q   + + ++++ Q + + ++ + Q+   +Q+Q +Q +Q++++  Q+Q +Q +  +Q
Sbjct: 3916 QQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQ-LQQQQQQQQQQFQQQQQQQQ 3974

Query: 535  NWLAEQQK--MQEQQMQEQAAQLSTTFQAQ 562
              L  Q +  +  QQ Q+Q   L     A+
Sbjct: 3975 MGLLNQSRTLLSPQQQQQQQVALGPGMPAK 4004



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 1/77 (1%)

Query: 507  IQRQNEQMMQERERLHQE-QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRS 565
            +Q +  Q+ Q+R +L Q+ Q +Q +  +Q  L  Q  +Q+QQ Q    Q +     + + 
Sbjct: 3716 LQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQG 3775

Query: 566  LLSELQHAQRTVNNDDP 582
            L+    H    V    P
Sbjct: 3776 LMPPSSHQGLLVQQLSP 3792


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 38/131 (29%), Positives = 68/131 (51%), Gaps = 8/131 (6%)

Query: 446  YREPRKGIQAE----EVLQK-YLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAE 500
            ++E R+ + A+    EV Q+   K  E +S  +  +DQA    ++K K  Q +    + E
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE 1585

Query: 501  AQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            AQRL A   + +  + ++E+  +    QME AK ++  + +K Q Q++QEQ   L    Q
Sbjct: 1586 AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY--DAKKQQNQELQEQLRSLE-QLQ 1642

Query: 561  AQNRSLLSELQ 571
             +N+ L +E +
Sbjct: 1643 KENKELRAEAE 1653



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 55/270 (20%), Positives = 113/270 (41%), Gaps = 17/270 (6%)

Query: 322 NSAAVQKAIAHYDQQMGQKVQLPMETL-QELLDLHRTSEREAIEVFMKNSFKDVDQSFQK 380
           N +  ++ +    Q  G ++   + +L  EL  L+ T +++  E+          Q+ +K
Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ-----QAKEK 531

Query: 381 ELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEE 440
           + +     +Q +   + L    +  S+ LK     L+E  ++   ++           EE
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591

Query: 441 LKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQT-----DQALTE-TEKKKKEAQVKA 494
            +A   RE    ++  E L+K   +K  +    LQ      D A T  T+ ++++A++  
Sbjct: 592 REASL-RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650

Query: 495 EAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQ 554
           + E+ +A    A Q Q+E   Q  E   Q +  Q +  ++  +A+    ++ Q+QEQ   
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ----EKDQLQEQLQA 706

Query: 555 LSTTFQAQNRSLLSELQHAQRTVNNDDPCV 584
           L  + +    SL  E + A   +     C+
Sbjct: 707 LKESLKVTKGSLEEEKRRAADALEEQQRCI 736



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 63/259 (24%), Positives = 105/259 (40%), Gaps = 30/259 (11%)

Query: 313  AVLALAQRENSAAVQKAIAHYDQQMGQKVQLP------------METLQELLDL--HRTS 358
            + LA AQRE +A   K   H   +   K Q+             + +L+E + +   +  
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242

Query: 359  EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE 418
            E+E     +K       +  QK LE  L   Q +    +  A+ +  SAL +++    EE
Sbjct: 1243 EKEGESKELKRLVMAESEKSQK-LEERLRLLQAETASNSARAA-ERSSALREEVQSLREE 1300

Query: 419  AVKQGIYSKPGGHNLFIQ--KTEELKAKYYREPRKGIQAEEVLQ----KYLKSKESVSHA 472
            A KQ + S+     L  Q  + EEL  +      K  Q E+ L     ++  ++  VS  
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360

Query: 473  I--------LQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQE 524
            +        LQ +QA  E   +++  Q K  A    A+ L A +   E +   ++   QE
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420

Query: 525  QVRQMEIAKQNWLAEQQKM 543
            +  Q   A++   AEQ  M
Sbjct: 1421 RTAQQLRAEKASYAEQLSM 1439



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 27/129 (20%), Positives = 56/129 (43%), Gaps = 10/129 (7%)

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            +G ++++  Q+       +   + Q +QA    + + ++A+   +A+K + Q L    R 
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRS 1637

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSEL 570
             EQ+ +E + L  E  R             +  Q     ++A Q      AQ RSL +++
Sbjct: 1638 LEQLQKENKELRAEAER----------LGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQV 1687

Query: 571  QHAQRTVNN 579
             HA + + +
Sbjct: 1688 AHADQQLRD 1696



 Score = 30.4 bits (67), Expect = 4.7
 Identities = 58/265 (21%), Positives = 108/265 (40%), Gaps = 37/265 (13%)

Query: 342 QLPMETLQELLDLHRTSEREAIEVF-----MKNSFKDVDQSFQKELETLLDAKQNDICKR 396
           +L  ET + L++ H+   +E  E       ++   + + ++ Q E E L       +  +
Sbjct: 738 ELKAET-RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796

Query: 397 NLEASSDYCSALLKDIFGPLEE----AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRK- 451
           +   S   C  L+K++    E       ++  Y       L   K E  KA+   +  K 
Sbjct: 797 HTAESE--CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854

Query: 452 ---GIQAEEVLQKYLKSKESVS-HAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
              GI++   LQ   +  E    HA L   +AL + ++K+  AQ  A+      +++AA 
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLA--RALQQVQEKEVRAQKLADDLSTLQEKMAAT 912

Query: 508 QRQNEQMMQ-ERERLHQEQVRQMEIAKQ---------NWLAEQQKMQ-------EQQMQE 550
            ++  ++    R+   Q++    E+ K+          WL EQQ  Q        Q M+ 
Sbjct: 913 SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972

Query: 551 QAAQLSTTFQAQNRSLLSELQHAQR 575
           +A Q+    + + R+ L E Q  Q+
Sbjct: 973 EAEQMGNELE-RLRAALMESQGQQQ 996



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 25/121 (20%), Positives = 57/121 (47%), Gaps = 10/121 (8%)

Query: 440 ELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTET-----EKKKKEAQVKA 494
           EL+ +   E +K  + E V Q+    K+ +   +    ++L  T     E+K++ A    
Sbjct: 675 ELELQLRSEQQKATEKERVAQE----KDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730

Query: 495 EAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEI-AKQNWLAEQQKMQEQQMQEQAA 553
           E ++  ++  A  +   EQ  +ER+ L +E+  +  + A+   L E  + + + ++ + A
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA 790

Query: 554 Q 554
           +
Sbjct: 791 E 791



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 28/133 (21%), Positives = 64/133 (48%), Gaps = 16/133 (12%)

Query: 453  IQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNE 512
            ++ ++  +KY++   +V  A  +T  A  + E +    +++    K E  ++  ++ + +
Sbjct: 1467 VELDQAREKYVQELAAV-RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE-ERQ 1524

Query: 513  QMMQERERL----------HQEQVRQMEIAKQNWLAEQQ--KMQEQQMQEQAAQLSTTFQ 560
            +  +ER++L           +EQ +Q+E   +      Q  K+Q+Q+++   AQ   + Q
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584

Query: 561  AQNR--SLLSELQ 571
               R  + L+ELQ
Sbjct: 1585 EAQRLQAQLNELQ 1597


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2365

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2483

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2544 ERQRLVASMEEARR 2557



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1940 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1994 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2111 VEEAERLKQS 2120



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERS 1446



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2182

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2183 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2347

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2348 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2458

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2459 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2509

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2510 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2039

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1384 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1442 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1492

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1544

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1545 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1601 VAVAQLREEAER 1612



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1587

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1640

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1755

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2142

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2143 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1389

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1446

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1565 VALETAQRSAEAELQ 1579



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2260

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2381 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1839

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1775

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2369

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2487

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2548 ERQRLVASMEEARR 2561



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1944 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1998 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2115 VEEAERLKQS 2124



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERS 1450



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2186

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2187 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2351

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2352 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2462

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2463 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2513

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2514 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2572 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2043

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1388 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1446 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1496

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1548

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1549 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1604

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1605 VAVAQLREEAER 1616



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1591

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1644

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1759

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2146

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2147 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2323

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2324 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2372



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1279 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1338

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1393

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1394 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1450

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1568

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1569 VALETAQRSAEAELQ 1583



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2264

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2385 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1843

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1779

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2530 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2365

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2483

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2544 ERQRLVASMEEARR 2557



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1940 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1994 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2111 VEEAERLKQS 2120



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERS 1446



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2182

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2183 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2347

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2348 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2458

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2459 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2509

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2510 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2039

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1384 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1442 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1492

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1544

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1545 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1601 VAVAQLREEAER 1612



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1587

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1640

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1755

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2142

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2143 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1389

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1446

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1565 VALETAQRSAEAELQ 1579



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2260

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2381 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1839

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1775

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2333

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2451

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2512 ERQRLVASMEEARR 2525



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1908 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1962 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2079 VEEAERLKQS 2088



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERS 1414



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2150

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2151 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2315

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2316 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2426

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2427 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2477

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2478 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2536 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2007

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1352 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1410 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1460

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1512

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1513 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1568

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1569 VAVAQLREEAER 1580



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1555

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1608

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1723

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2110

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2111 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2287

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2288 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2336



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1243 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1302

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1357

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1358 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1414

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1532

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1533 VALETAQRSAEAELQ 1547



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2228

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2349 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1807

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1743

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1794



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2494 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2502

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2620

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2681 ERQRLVASMEEARR 2694



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 2077 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 2131 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2248 VEEAERLKQS 2257



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERS 1583



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2319

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2320 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2484

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2485 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2595

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2596 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2646

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2647 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2176

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1521 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1579 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1629

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1681

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1682 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1737

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1738 VAVAQLREEAER 1749



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1724

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1777

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1892

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2279

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2280 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2456

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2457 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2505



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1412 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1471

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1526

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1527 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1583

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1701

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1702 VALETAQRSAEAELQ 1716



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2397

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2518 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1976

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1912

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1963



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2663 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2343

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2461

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2522 ERQRLVASMEEARR 2535



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1918 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1971

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1972 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2089 VEEAERLKQS 2098



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERS 1424



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2160

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2161 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2325

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2326 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2436

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2437 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2487

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2488 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2546 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2017

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1362 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1420 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1470

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1522

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1523 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1578

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1579 VAVAQLREEAER 1590



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1565

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1618

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1733

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2120

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2121 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2297

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2298 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2346



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1253 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1312

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1367

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1368 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1424

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1542

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1543 VALETAQRSAEAELQ 1557



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2238

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2359 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1817

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1753

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1804



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2504 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2598


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2351

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2411

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2469

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2530 ERQRLVASMEEARR 2543



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1926 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1979

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 1980 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2097 VEEAERLKQS 2106



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERS 1432



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2111 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2168

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2169 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2333

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2334 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2444

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2445 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2495

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2496 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2554 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2025

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1370 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1428 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1478

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1530

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1531 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1586

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1587 VAVAQLREEAER 1598



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1573

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1626

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1741

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2128

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2129 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2305

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2306 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2354



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1261 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1320

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1375

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1376 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1432

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1550

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1551 VALETAQRSAEAELQ 1565



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2246

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2367 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1825

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1761

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1812



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2512 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2606


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 66/314 (21%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE------REAIE 364
            EN  L L  ++N+    +  A   +Q+ ++        QE   L + +E      R   E
Sbjct: 2277 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336

Query: 365  VFMKNSFKDVDQSFQKELETLLDAKQNDICK---RNLEASSDYCSALLKDIFGPLEEAVK 421
              +K   + V ++ + + E  L  +Q ++ +   R L+   +  +  L +      +  +
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE----TQGFQ 2392

Query: 422  QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD---- 477
            + + ++         + E LK +     R   +AEE  Q++ K  E +   + +T+    
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2452

Query: 478  ------------------------QALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQ 513
                                    +A+ E E++K++ Q +A+  + +++ +  +Q+  EQ
Sbjct: 2453 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQ 2510

Query: 514  MMQERERLHQ-----------------------EQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            ++QE + L Q                       EQ+ Q E+AK   L E+Q+ Q+QQM++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570

Query: 551  QAAQLSTTFQAQNR 564
            +  +L  + +   R
Sbjct: 2571 ERQRLVASMEEARR 2584



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 30/250 (12%)

Query: 348  LQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA 407
            L+E    H+    E +    K S  ++++      +TL   +Q +     L+AS +  +A
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966

Query: 408  LLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYR-----EPRKGIQAEEVLQKY 462
                  G  E  ++ G         L  ++  EL+A   R     E R+  +AEE +QK 
Sbjct: 1967 ------GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2020

Query: 463  LKSKESVSHAILQTDQALTETEKKKKEAQ----VKAEAEKAEAQRLAAIQRQNEQMMQER 518
            L ++E  +    Q   AL E E+ K + +    ++  AE+  A++L   Q   ++ +Q  
Sbjct: 2021 LAAEEEAAR---QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077

Query: 519  ERLHQEQVRQMEIAKQNWLAEQQKMQEQ------------QMQEQAAQLSTTFQAQNRSL 566
            E+ H   V+Q E   Q  L ++Q + +Q            +  E+A   +    AQ+R  
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137

Query: 567  LSELQHAQRT 576
            + E +  +++
Sbjct: 2138 VEEAERLKQS 2147



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 16/146 (10%)

Query: 447  REPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL---TETEKKKKEAQVKAEAEKAEA-Q 502
            ++P+    +E V+Q+Y+  +   S     T Q +   +ET ++ +E +  AE ++AE  +
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387

Query: 503  RLAAIQRQNEQMMQ------------ERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQE 550
            RLA ++   E+  Q            ERE    +Q  Q E+ ++   A   + Q++ +QE
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447

Query: 551  QAAQLSTTFQAQNRSLLSELQHAQRT 576
            +  QL  + +A+ ++   + + A+R+
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERS 1473



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/278 (21%), Positives = 120/278 (43%), Gaps = 36/278 (12%)

Query: 316  ALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
            A A+ +  AA +K     +Q+  ++ Q     L++       +E E  + F + + +   
Sbjct: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKKFAEQTLRQKA 2209

Query: 376  QSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLF 434
            Q  ++EL TL L  ++ D  K  L+         L+ +     EA +Q    +    ++ 
Sbjct: 2210 Q-VEQELTTLRLQLEETDHQKNLLDEE-------LQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 435  IQKTE--ELKAKYYREPRKGI-----QAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            +Q  E  +LKA+   E R  I       +  LQ+  +  + V+    +   A  E  + +
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321

Query: 488  KEA-----QVKAEAEKAEAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAKQNWL 537
            + A     Q +A AEK   +++ A+Q     +   +++Q+++ L QEQ R+++       
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ------- 2374

Query: 538  AEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
             E ++   QQ+ E+      T +A+ +  L     A+R
Sbjct: 2375 -EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 68/287 (23%), Positives = 129/287 (44%), Gaps = 37/287 (12%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETL----QELLDLHRTSEREAIEVFMKNSFK--- 372
            +E +  +Q+      QQ+ ++ Q    TL    Q  L++   +ER  + V   +  +   
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426

Query: 373  -DVDQSFQKELE--------TLLDAKQNDICKRNLEAS---SDYCSALLKDIFGPLEEAV 420
             +  Q F+K+ E        T L  ++     + LE     SD+ +  L++    LE   
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE- 2485

Query: 421  KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
            K+ +  +     L   K+EE++     +  +  QA +  Q +L  K+S    +LQ ++ +
Sbjct: 2486 KEKLQQEA---KLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDS----LLQRERFI 2536

Query: 481  TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---HQEQVRQMEIAKQNWL 537
             E EK K E   + E  KA+  R    QRQ +QM QER+RL    +E  R+   A++   
Sbjct: 2537 -EQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594

Query: 538  AEQQKMQE---QQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDD 581
             +Q+++Q+   Q+ Q++        + + +  L E QH     ++++
Sbjct: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/288 (20%), Positives = 119/288 (41%), Gaps = 31/288 (10%)

Query: 310  IENAVLALAQRENSAAVQKAI---------AHYDQQMGQKVQLPMETLQE--LLDLHRTS 358
            +E  +LAL      AA  KA          ++ +  +  K Q  +E  ++  L       
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009

Query: 359  EREAIEVFMKNSFKDVDQSFQKE--LETLLDAKQNDICKRNLEASSDYCSALLKDIFGPL 416
             REA E   K+   + + + Q++  LE +   K      R L   ++  SA    +    
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL---A 2066

Query: 417  EEAVKQGIYSKPGGHNLFIQ-KTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQ 475
            +EA ++ + ++   H   +Q K +EL+    +E     Q     +   ++ E    A +Q
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126

Query: 476  TDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER------------LHQ 523
             ++   ++ ++ +EA+   ++ + +AQ  A  Q   E++ +E E+            L Q
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186

Query: 524  EQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQA--QNRSLLSE 569
            +Q    E+ K    AEQ   Q+ Q++++   L    +     ++LL E
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 48/312 (15%)

Query: 289  SRLKNLVLTYVNAISSGDLPCIENAVLALAQR----ENSAAVQKAIAHYDQQMGQKVQLP 344
            S L  L   Y+  IS       E   LA  QR    E  A V+ A+    Q      Q  
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410

Query: 345  METLQELLDLHRTSEREAIEVFMKNSFKDVDQ---SFQKELETLLDAKQNDICKRNLEAS 401
             +  +E  +L +  + E +    + +  D  Q   S Q+EL+ L  + + +I  +  +A 
Sbjct: 1411 AQAEREAKELQQRMQEEVVR--REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468

Query: 402  SDYCSALLKDIFGPLEEAVK------QGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            +   S L       +EE ++      +    + GG    +Q    L+A+      +  QA
Sbjct: 1469 AAERSRLR------IEEEIRVVRLQLEATERQRGGAEGELQA---LRARAEEAEAQKRQA 1519

Query: 456  EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKA-EAQR-LAAIQRQNEQ 513
            +E  ++  +  +  S    Q +  L         ++VKAEAE A E QR L A++    Q
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELA--------SRVKAEAEAAREKQRALQALEELRLQ 1571

Query: 514  MMQERERLHQ---EQVRQMEIAKQNWLAEQQKMQEQQMQ-------EQAAQLSTTFQAQN 563
              +   RL Q   E+ RQ+++A    L   Q+  E ++Q       E+ AQL  + Q ++
Sbjct: 1572 AEEAERRLRQAEVERARQVQVA----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1627

Query: 564  RSLLSELQHAQR 575
             ++    + A+R
Sbjct: 1628 VAVAQLREEAER 1639



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/273 (20%), Positives = 114/273 (41%), Gaps = 24/273 (8%)

Query: 311  ENAVLALAQ-RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKN 369
            + A+ AL + R  +   ++ +   + +  ++VQ+ +ET Q   +    S+R +       
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA----E 1614

Query: 370  SFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPG 429
                +++S Q+E   +   ++    +   +A ++             E  +++       
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE-------EAERELERWQLKANE 1667

Query: 430  GHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
               L +Q  E  + K   +     Q EE  ++  +  ++   A+ Q + A  E EK+++ 
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727

Query: 490  AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVR-QMEIAKQNWLAEQQKMQEQQM 548
            A+  A+   A  Q L  ++ + EQ  Q+R+ L +E  R Q E A     A  QK QE + 
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-----AATQKRQELEA 1782

Query: 549  Q------EQAAQLSTTFQAQNRSLLSELQHAQR 575
            +      E    L++  +A+  S  +  +  QR
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/289 (22%), Positives = 114/289 (39%), Gaps = 33/289 (11%)

Query: 311  ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNS 370
            E A  A  Q E  AA  +      +++ Q  +   +         R   + A E   K +
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA--------RAQAQAAAEKLRKEA 2169

Query: 371  FKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG 430
             ++  +  Q E   L   +Q       +E    +    L+      +E     +  +   
Sbjct: 2170 EQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226

Query: 431  H--NLFIQKTEELKAKYYREPRKGIQAEEVLQKY---------LKSK-ESVSHAILQTDQ 478
            H  NL  ++ + LKA+     R+  Q EE L            LK++ E+ + A++  D+
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286

Query: 479  ALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER---ERLHQEQVRQM 529
              T      E EK K+ A+  A    A  +     Q   E + Q+R   E++ +E+++ +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2346

Query: 530  -EIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
             E  +    AE  + Q++  QEQA +L    +   + L  E Q  QRT+
Sbjct: 2347 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2395



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 66/315 (20%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 298  YVNAISSGDL----------PCIENAVLALAQRENSAAVQKAI---AHYDQQM---GQKV 341
            Y+NAI   +L          P    A     Q  + + +Q+ +    HY +      Q +
Sbjct: 1302 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1361

Query: 342  QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEAS 401
            +   ETL+ + +  R +E++  E   +    +V+ + +K+ +    A+ +   K   E  
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1416

Query: 402  SDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQK 461
            +      +++     EEA       K        Q  +  +A+   + R   QAE   + 
Sbjct: 1417 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERS 1473

Query: 462  YLKSKESVSHAILQTD-------------QALT----ETEKKKKEAQVKAEAEKAEAQRL 504
             L+ +E +    LQ +             QAL     E E +K++AQ +AE  + + Q  
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 505  AAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQ--------EQAAQLS 556
            +  +RQ E  +  R +   E  R+ + A Q    E+ ++Q ++ +        E+A Q+ 
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQ 1591

Query: 557  TTFQAQNRSLLSELQ 571
               +   RS  +ELQ
Sbjct: 1592 VALETAQRSAEAELQ 1606



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 43/284 (15%)

Query: 316  ALAQRENS-AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER-----EAIEVFMKN 369
            AL Q++ + A ++K     +Q + QK Q+  E     L L  T  +     E ++     
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242

Query: 370  SFKDVDQSFQKELETL-LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKP 428
            + +   Q  Q E E   +  +  ++ K      ++  + +L+D               K 
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---------------KD 2287

Query: 429  GGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKK 488
                   ++ E++K       R  + A+E  +    ++E ++      ++ L E  +  +
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347

Query: 489  EA-QVKAEAEKAEAQRLAA------IQRQNEQMMQE--------RERLHQEQVRQMEIAK 533
            EA ++KAEAE  + Q+  A      +Q   EQM Q+        +  L  E+ RQ+E++ 
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407

Query: 534  QNWLAEQQKMQEQQM---QEQAAQLSTTFQAQNRSLLSELQHAQ 574
            +   AE+ K++  +M   Q +A + +  F+ Q   +  +L   +
Sbjct: 2408 E---AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 418  EAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTD 477
            E  KQ + ++ G      ++   L+A      R+   AEE   +     E V   + +  
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV---LAEKL 1866

Query: 478  QALTETEKKKKEAQV---KAEAEKAEAQRLA---AIQRQ--NEQMMQER----ERLHQ-E 524
             A+ E  + K EA++   + EAE    +RLA   A QR+   EQ  Q +    ERL Q  
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 525  QVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQ 560
            +    E+ +Q  L E    Q +Q++E+   L  +F+
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 448  EPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAI 507
            E  +G Q  ++L++ L   +  + A  Q  Q L     + + A+V+AE E   A +  A 
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQEL-----EAELAKVRAEMEVLLASKARAE 1802

Query: 508  QRQNEQMMQERERLHQEQVRQMEIAKQ----NWLAEQQKMQEQQMQEQAAQ 554
            +       + ++RL  E  R  E+A++      LAE+ K Q Q  +E AA+
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1853



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 39/218 (17%), Positives = 96/218 (44%), Gaps = 12/218 (5%)

Query: 335  QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDIC 394
            +++G+K+       QE + L +T     +E+  + S  D ++  +   E   + ++    
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492

Query: 395  KRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGG----HNLFIQKTEELKAKYYREPR 450
             + L+  S+    + ++      +A++Q   S+            Q+  +L+  +  E  
Sbjct: 2493 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552

Query: 451  KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
            K  Q  E  Q+  +  E     ++ +   + E  +++ EA+     ++ E Q+L   +RQ
Sbjct: 2553 KAQQLREEQQRQQQQMEQERQRLVAS---MEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609

Query: 511  NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
             E+++ E  +  +EQ++ +E   +  LA  +++   Q+
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2647


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 59/247 (23%), Positives = 111/247 (44%), Gaps = 20/247 (8%)

Query: 336 QMGQKVQLPMETLQELLDLHRTSE-----REAIEVFMKNSFKDVDQSFQKELETLLDAKQ 390
           +M  K     +  Q L +L R  E     R+ +E   +   ++V    ++ L  +L A++
Sbjct: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARE 586

Query: 391 NDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPR 450
               ++  E            I    E+A ++ +  +        +K EE++A+     R
Sbjct: 587 R--VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-----R 639

Query: 451 KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
           K  +    L+   + +E   H  L   +   E E+ +K A+ K  AE+ E +R    +R+
Sbjct: 640 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699

Query: 511 NEQMMQE-RERLHQEQVRQMEIAKQNWLAEQQKMQ-EQQMQEQAAQLSTTFQAQNRSLLS 568
            E+  QE RE+  +EQ RQ  +A+Q    EQ+++Q E+++QE+   L    + Q   L  
Sbjct: 700 QERREQERREQERREQERQ--LAEQERRREQERLQAERELQEREKAL----RLQKEQLQR 753

Query: 569 ELQHAQR 575
           EL+  ++
Sbjct: 754 ELEEKKK 760



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 52/205 (25%), Positives = 93/205 (45%), Gaps = 27/205 (13%)

Query: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419
           RE +E   +   K ++Q F +  E    AK+  + +           A  K     +EE 
Sbjct: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK---------AKKKAAAKKMEEV 635

Query: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479
             +    +      ++Q+ EE +       +K  + +E L+K  ++K        Q +Q 
Sbjct: 636 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE----QREQE 691

Query: 480 LTETEKKKKEA--QVKAEAEKAEAQRLAAIQR--------QNEQMMQERE---RLHQEQV 526
             E E++++E   Q + E E+ E +R  A Q         Q E+ +QERE   RL +EQ+
Sbjct: 692 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL 751

Query: 527 RQMEIAKQNWLAEQQKMQEQQMQEQ 551
            Q E+ ++    EQQ++ E+Q+QE+
Sbjct: 752 -QRELEEKKKKEEQQRLAERQLQEE 775



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 43/182 (23%), Positives = 82/182 (45%), Gaps = 31/182 (17%)

Query: 436 QKTEELKAKYYREPRKGIQAEE-VLQKYLKSKESVSHAILQTDQA--------LTETEKK 486
           ++ EE+K K     RK +QA E V Q   + K+ +     Q D+         L E + K
Sbjct: 565 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 624

Query: 487 KKEAQVKAEAEKA------EAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAK-- 533
           KK A  K E  +A      EA+RL  +Q     R++++++Q+++   QE++R+   AK  
Sbjct: 625 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRL 684

Query: 534 ---------QNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCV 584
                    +    EQ++ ++++ +++  +       Q R    E   A+R +   +  +
Sbjct: 685 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 744

Query: 585 LL 586
            L
Sbjct: 745 RL 746


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 34/122 (27%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 435 IQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKA 494
           +QK EE   K   + RK  Q E++ ++  + +E     + Q +Q   E +  ++E Q++ 
Sbjct: 243 VQKQEEQVQKQEEQMRK--QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300

Query: 495 EAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNW-LAEQQKMQEQQMQEQAA 553
           + E+   Q    ++ Q EQM ++ E++ +++ +  E  +Q W   EQ   QE+QM EQ  
Sbjct: 301 QEEQMREQE-EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEE 359

Query: 554 QL 555
           Q+
Sbjct: 360 QM 361



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 29/120 (24%), Positives = 58/120 (48%)

Query: 436 QKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAE 495
           Q  E+ +    +E + G Q E++ ++  +  E       Q +Q   + E+ +K+ +   E
Sbjct: 207 QMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266

Query: 496 AEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQL 555
            E+   ++   + +Q EQ  QE +   QE+  + +  +     EQ + QE+QM+EQ  Q+
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 32/127 (25%), Positives = 63/127 (49%), Gaps = 7/127 (5%)

Query: 435 IQKTEELKAKYYREPRKGIQA----EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEA 490
           +QK EE   +   + RK  +     EE +QK  +  +     + + ++ + E E++ +E 
Sbjct: 215 MQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ 274

Query: 491 QVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQ--EQVRQMEIAKQNWLAEQQKMQEQQM 548
           + +   +K + ++      Q EQM ++ E++ +  EQ+R+ E  +     EQ   QE+QM
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE-EQMREQEEQMGKQEEQM 333

Query: 549 QEQAAQL 555
            EQ  Q+
Sbjct: 334 WEQKEQM 340



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 31/116 (26%), Positives = 62/116 (53%), Gaps = 7/116 (6%)

Query: 447 REPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAA 506
           +E + G Q  ++ ++  +  E       Q +Q   + E+ +K+ +   E E+   ++   
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249

Query: 507 IQRQNEQMMQERERL--HQEQVRQME--IAKQNWLAEQQKM---QEQQMQEQAAQL 555
           +Q+Q EQM ++ E++   +EQ+R+ E  + KQ    EQ++    QE+QM+EQ  Q+
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM 305



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 46/238 (19%), Positives = 107/238 (44%), Gaps = 18/238 (7%)

Query: 319 QRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSF 378
           Q E     ++ +   ++QMG++ +   +  +++ +     +++  +V  +       +  
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ 263

Query: 379 QKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKT 438
            +E E  +  ++  + K+  +   +       +  G  EE +++             ++ 
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQE-------EQTGEQEEQMREQEEQMREQEEQMREQE 316

Query: 439 EELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK-KKKEAQVKAEAE 497
           E+++ +   E + G Q E++ ++  +  E       Q +Q   + E+ +K+E QV+ + E
Sbjct: 317 EQMREQ---EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373

Query: 498 KAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQL 555
           +   Q    +++Q EQM ++ E++  EQ  QM   K     EQ + QE+QM EQ  Q+
Sbjct: 374 QMRKQE-EQMRKQEEQMRKQEEQM-GEQKEQMGEQK-----EQMREQEEQMGEQKEQM 424



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 47/238 (19%), Positives = 101/238 (42%), Gaps = 26/238 (10%)

Query: 319 QRENSAAVQKAIAHYDQQMGQK---VQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVD 375
           Q E     ++ +   ++QMG++   VQ   E +Q+  +  R  E +  E   +   ++ +
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE--QEEQMREQE 275

Query: 376 QSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFI 435
           +   K+ E     +Q    +  +    +      + +    E+  +Q          ++ 
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335

Query: 436 QKTE--ELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVK 493
           QK +  E K + +++  +  + EE +QK             Q +Q   + E+ +K+ +  
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQK-------------QEEQVRKQEEQMRKQEEQM 382

Query: 494 AEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQ 551
            + E+   ++   +  Q EQM +++E++ +EQ  QM   K     EQ + QE+ M EQ
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQM-REQEEQMGEQK-----EQMRKQEEHMGEQ 434



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 47/240 (19%), Positives = 107/240 (44%), Gaps = 20/240 (8%)

Query: 334 DQQMGQK---VQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQ 390
           ++QMG++   +Q   E + E  +  R  E +  E   +   +  ++  QK+ E +   KQ
Sbjct: 205 EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE--QEEQVQKQEEQVQKQEEQM--RKQ 260

Query: 391 NDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPR 450
            +  +   E   +    +LK      +E  +Q    + G     +++ EE   +   + R
Sbjct: 261 EEQMREQEEQMREQEEQMLKQ-----KEQTEQE--EQTGEQEEQMREQEEQMREQEEQMR 313

Query: 451 KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQ 510
           +  Q E++ ++  +  +       Q +Q   + E+  K+ +   E E+   ++   +++Q
Sbjct: 314 E--QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ 371

Query: 511 NEQMMQERERLH--QEQVRQME--IAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSL 566
            EQM ++ E++   +EQ+R+ E  + +Q     +QK Q ++ +EQ  +     + Q   +
Sbjct: 372 EEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431



 Score = 36.6 bits (83), Expect = 0.066
 Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 19/105 (18%)

Query: 482 ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL---------HQEQVRQME-- 530
           E +  ++E Q+  E E+   ++   +Q+Q EQM ++ E++          +EQV++ E  
Sbjct: 191 EGQMGEQEGQM-GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249

Query: 531 IAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
           + KQ    EQ + QE+QM+EQ  Q+    + Q   +L + +  ++
Sbjct: 250 VQKQE---EQMRKQEEQMREQEEQM----REQEEQMLKQKEQTEQ 287



 Score = 36.2 bits (82), Expect = 0.086
 Identities = 30/141 (21%), Positives = 62/141 (43%), Gaps = 4/141 (2%)

Query: 436 QKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK--KKKEAQVK 493
           Q  E+ +    +E +   Q E++ ++  + +E       Q +Q   + E+  ++KE   K
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349

Query: 494 AEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQME--IAKQNWLAEQQKMQEQQMQEQ 551
            E +  E +     Q +  +  +E+ R  +EQ+R+ E  + KQ     +QK Q  + +EQ
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQ 409

Query: 552 AAQLSTTFQAQNRSLLSELQH 572
             +       Q   +  + +H
Sbjct: 410 MREQEEQMGEQKEQMRKQEEH 430



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 19/74 (25%), Positives = 37/74 (50%)

Query: 482 ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQ 541
           E + +++E QV+ +  +   Q     +++ +   QE +   QE+  Q +  +     EQ 
Sbjct: 170 EGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQM 229

Query: 542 KMQEQQMQEQAAQL 555
           + QE+QM EQ  Q+
Sbjct: 230 RKQEEQMGEQEEQV 243



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 22/76 (28%), Positives = 45/76 (59%), Gaps = 4/76 (5%)

Query: 482 ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQ 541
           E + +++E QV+ E E    ++   +  Q EQM ++ E++ Q+Q  QM   ++    +++
Sbjct: 177 EGQVREQEGQVR-EQEGQMGEQEGQMGEQEEQMGEQEEQM-QKQEEQMGEQEEQMRKQEE 234

Query: 542 KM--QEQQMQEQAAQL 555
           +M  QE+Q+Q+Q  Q+
Sbjct: 235 QMGEQEEQVQKQEEQV 250



 Score = 32.7 bits (73), Expect = 0.95
 Identities = 22/76 (28%), Positives = 43/76 (56%), Gaps = 4/76 (5%)

Query: 482 ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERL--HQEQVRQMEIAKQNWLAE 539
           E + +++E Q+  E E    ++   +  Q EQM ++ E++   +EQ+R+ E  +     E
Sbjct: 184 EGQVREQEGQM-GEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE-EQMGEQEE 241

Query: 540 QQKMQEQQMQEQAAQL 555
           Q + QE+Q+Q+Q  Q+
Sbjct: 242 QVQKQEEQVQKQEEQM 257



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 19/85 (22%), Positives = 43/85 (50%), Gaps = 2/85 (2%)

Query: 473 ILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIA 532
           + + +  + E E + +E + +   ++ + +      R+ E  M E+E    EQ  QM   
Sbjct: 152 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211

Query: 533 KQNWLAEQQKM--QEQQMQEQAAQL 555
           ++    ++++M  QE+QM++Q  Q+
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQM 236



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 20/86 (23%), Positives = 45/86 (52%), Gaps = 4/86 (4%)

Query: 473 ILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIA 532
           + + +  + E E + +E + +   ++ + +      R+ E  ++E+E   +EQ  QM   
Sbjct: 138 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG-E 196

Query: 533 KQNWLAEQQKM---QEQQMQEQAAQL 555
           ++  + EQ++    QE+QMQ+Q  Q+
Sbjct: 197 QEGQMGEQEEQMGEQEEQMQKQEEQM 222


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 57/234 (24%), Positives = 107/234 (45%), Gaps = 20/234 (8%)

Query: 349 QELLDLHRTSE-----REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSD 403
           Q L +L R  E     R+ +E   +   ++V    ++ L  +L A++    ++  E    
Sbjct: 536 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER--VEQMKEEKKK 593

Query: 404 YCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYL 463
                   I    E+A ++ +  +        +K EE++A+     RK  +    L+   
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-----RKQEEEARRLRWLQ 648

Query: 464 KSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQE-RERLH 522
           + +E   H  L   +   E E+ +K A+ K  AE+ E +R    +R+ E+  QE RE+  
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708

Query: 523 QEQVRQMEIAKQNWLAEQQKMQ-EQQMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
           +EQ RQ  +A+Q    EQ+++Q E+++QE+   L    + Q   L  EL+  ++
Sbjct: 709 REQERQ--LAEQERRREQERLQAERELQEREKAL----RLQKEQLQRELEEKKK 756



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 51/205 (24%), Positives = 93/205 (45%), Gaps = 27/205 (13%)

Query: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419
           RE +E   +   K ++Q F +  E    AK+  + +           A  K     +EE 
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK---------AKKKAAAKKMEEV 631

Query: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479
             +    +      ++Q+ EE +       +K  + +E L+K  ++K        Q +Q 
Sbjct: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE----QREQE 687

Query: 480 LTETEKKKKEA--QVKAEAEKAEAQRLAAIQ---RQNEQMMQERE--------RLHQEQV 526
             E E++++E   Q + E E+ E +R  A Q   R+ E++  ERE        RL +EQ+
Sbjct: 688 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL 747

Query: 527 RQMEIAKQNWLAEQQKMQEQQMQEQ 551
            Q E+ ++    EQQ++ E+Q+QE+
Sbjct: 748 -QRELEEKKKKEEQQRLAERQLQEE 771



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 43/182 (23%), Positives = 82/182 (45%), Gaps = 31/182 (17%)

Query: 436 QKTEELKAKYYREPRKGIQAEE-VLQKYLKSKESVSHAILQTDQA--------LTETEKK 486
           ++ EE+K K     RK +QA E V Q   + K+ +     Q D+         L E + K
Sbjct: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 620

Query: 487 KKEAQVKAEAEKA------EAQRLAAIQ-----RQNEQMMQERERLHQEQVRQMEIAK-- 533
           KK A  K E  +A      EA+RL  +Q     R++++++Q+++   QE++R+   AK  
Sbjct: 621 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRL 680

Query: 534 ---------QNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCV 584
                    +    EQ++ ++++ +++  +       Q R    E   A+R +   +  +
Sbjct: 681 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 740

Query: 585 LL 586
            L
Sbjct: 741 RL 742



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 23/120 (19%), Positives = 61/120 (50%), Gaps = 5/120 (4%)

Query: 453 IQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAA--IQRQ 510
           +Q  ++L     +  SV  + ++ +  L    K+K+  +++    K EA++L    ++  
Sbjct: 499 VQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEED 558

Query: 511 NEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQ-EQQMQEQAAQLSTTFQAQNRSLLSE 569
             + ++E +   +E++R++  A++    EQ K + ++Q++++ AQ+    +      L+E
Sbjct: 559 KRRRLEEVKLKREERLRKVLQARER--VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 616


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 59/251 (23%), Positives = 119/251 (47%), Gaps = 33/251 (13%)

Query: 335 QQMGQKVQLPMETLQELLDLHR------TSEREAIEVFMKNSFKDVDQSFQKELETLLDA 388
           QQ  ++ +  ++  +E +  H+      TSE+EA++       + +D+  Q ELE + D 
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQ-------EQLDERLQ-ELEKIKDL 336

Query: 389 KQNDICK--RNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYY 446
              +  K    L  + +    L +D    + E  +Q        H     K EE+     
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQM-------HETLEMKEEEIAQLRS 389

Query: 447 REPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAA 506
           R  +   Q EE+ ++  KS+ +   A  + ++AL+ T +K +EA+ K +AE  E  ++  
Sbjct: 390 RIKQMTTQGEELREQKEKSERA---AFEELEKALS-TAQKTEEARRKLKAEMDE--QIKT 443

Query: 507 IQRQNEQ----MMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQ 562
           I++ +E+    + QE  R+ QE V  M+ + +  +A+ QK+ E+++  +  +L+   Q +
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503

Query: 563 NRSLLSELQHA 573
            R    +++ A
Sbjct: 504 EREFQEQMKVA 514



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 36/145 (24%), Positives = 76/145 (52%), Gaps = 7/145 (4%)

Query: 436 QKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAE 495
           QKTEE + K   E  + I+  E   +  + + S+   + +  Q + +  KK  E Q+ A+
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSE--EERISLQQELSRVKQEVVDVMKKSSEEQI-AK 480

Query: 496 AEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQL 555
            +K   + LA  +++  + +Q RER  QE   QM++A +   +E  K+ +++ Q+++  L
Sbjct: 481 LQKLHEKELARKEQELTKKLQTREREFQE---QMKVALEKSQSEYLKISQEKEQQESLAL 537

Query: 556 STTFQAQNRSLLSELQHAQRTVNND 580
               + Q +++L+E ++  R +  +
Sbjct: 538 E-ELELQKKAILTESENKLRDLQQE 561



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 55/268 (20%), Positives = 107/268 (39%), Gaps = 46/268 (17%)

Query: 327 QKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLL 386
           +K +   D +  +   L  E  + L   H+  E  ++        KD     ++ELE  +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV-------LKDQTDKMKQELEAKM 725

Query: 387 DAKQN------DICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEE 440
           D ++N      D   +  E S       LKD    LE  +K+        H   ++  E 
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE-HQAHVENLEA 784

Query: 441 LKAKYYREPRKGIQAEEVLQKYLKSKESVSHAI-------------LQTDQAL-----TE 482
              +   E ++     +V Q Y  +    + A              L+T++ L      E
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844

Query: 483 TEKKKKEAQVKAEAEKAEAQRLAA-IQRQNEQMMQERERL-------------HQEQVRQ 528
            E +KK+   + +A K + Q L   +++QN +M Q+ + L              QEQ +Q
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904

Query: 529 MEIAKQNWLAEQQKMQEQQMQEQAAQLS 556
           + + K+N + + ++ Q+++++    +LS
Sbjct: 905 ILVEKENMILQMREGQKKEIEILTQKLS 932



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 47/237 (19%), Positives = 100/237 (42%), Gaps = 38/237 (16%)

Query: 339  QKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNL 398
            QK+   +  LQ+ L + R   ++ +E+  K   ++ ++  ++E E L + K N   K+ +
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL-ELKHNSTLKQLM 1998

Query: 399  EASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEV 458
               +   +   ++    LE  +K+ I            K +E++A             E+
Sbjct: 1999 REFNTQLAQKEQE----LEMTIKETI-----------NKAQEVEA-------------EL 2030

Query: 459  LQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQR-----LAAIQRQNEQ 513
            L+ + +    +   I + D  L  T K+ +E     E E     R     L  +Q++ +Q
Sbjct: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090

Query: 514  MMQERERLHQEQVRQMEI----AKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSL 566
             +++ E    + V  ME+    A++  L    K++EQ+ +EQ   L    +   +++
Sbjct: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 53/281 (18%), Positives = 121/281 (43%), Gaps = 24/281 (8%)

Query: 321  ENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQK 380
            E  + +Q+ +   ++ + +  Q   ET+    ++    +   I++    + +  DQS   
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIG 1795

Query: 381  ELETLLDAKQND---ICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQK 437
             L+  L+ K      I  +++E      +   K     + + V++ +  K     +  QK
Sbjct: 1796 HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855

Query: 438  TEELKAKYYREPR-KGIQAEEVLQKY--LKSKESVSHAILQTDQALTETEKKKKEAQVKA 494
             +EL +   R+     ++ EE+  KY  L++ + +      T+     TE+K K   V+ 
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQP 1915

Query: 495  EA-EKAEAQ------RLAAIQRQNEQMMQERERLHQ-------EQVRQMEIAKQNWLAEQ 540
            +     EAQ      +LA  +R+ +++ +E  RL +       E  +++EI K+ +  E+
Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER 1975

Query: 541  Q---KMQEQQMQ-EQAAQLSTTFQAQNRSLLSELQHAQRTV 577
            +   K +++ ++ +  + L    +  N  L  + Q  + T+
Sbjct: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 56/270 (20%), Positives = 110/270 (40%), Gaps = 21/270 (7%)

Query: 320  RENSAAVQKAIAHYDQQMGQKVQLPMETLQELLD-------LHRTSEREAIEVFMKNSFK 372
            +E+  ++Q+       Q+ Q   L  E  + L +       L    +R   E+   ++  
Sbjct: 741  KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800

Query: 373  DVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHN 432
            DV QS+Q        A +  + +   +        +L        EA K+ + ++   H 
Sbjct: 801  DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860

Query: 433  LFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQV 492
            + +Q   +   K   E  + +++  + Q Y    E  +    QT Q L E E    + + 
Sbjct: 861  IQVQDLMQQLEKQNSEMEQKVKS--LTQVYESKLEDGNKEQEQTKQILVEKENMILQMR- 917

Query: 493  KAEAEKAE----AQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQM 548
              E +K E     Q+L+A +     + +E E   + Q ++ME  KQ    E Q+  ++++
Sbjct: 918  --EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK-AKEMQETLKKKL 974

Query: 549  QEQAAQLSTTFQAQNRSLLSELQHAQRTVN 578
             +Q A+L    + +N +L  EL   ++  N
Sbjct: 975  LDQEAKLKK--ELENTAL--ELSQKEKQFN 1000



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 43/221 (19%), Positives = 97/221 (43%), Gaps = 31/221 (14%)

Query: 367  MKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYS 426
            +K   +D D+S  ++ E+ L+ +      R +E         ++     L E +K     
Sbjct: 1498 LKGEMED-DKSKMEKKESNLETELKSQTARIMELEDHITQKTIE--IESLNEVLKNYNQQ 1554

Query: 427  KPGGHNLFIQKTEELKAKYYREPRKGIQAEEV--------------LQKYLKSKESVSHA 472
            K   H   +QK +  +     +  +  +AEE               L+   K  E V+ +
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614

Query: 473  ILQTDQALT------ETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQV 526
            +   ++ L       E+E   K A++K +AE    Q++AAI++Q    M+E+E  +++  
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAE----QKIAAIKKQLLSQMEEKEEQYKKGT 1670

Query: 527  RQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLL 567
             +  +++ N   ++++ +   ++E   +L +   +Q+ +L+
Sbjct: 1671 -ESHLSELNTKLQEREREVHILEE---KLKSVESSQSETLI 1707


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 28/120 (23%), Positives = 68/120 (56%), Gaps = 2/120 (1%)

Query: 439 EELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEK 498
           ++L+A   ++    +Q +++ + Y K +E +   +LQ  Q   + ++++++ Q + + ++
Sbjct: 116 QQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQ 175

Query: 499 AEAQRLAAIQRQNEQMM--QERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLS 556
            + Q+    Q+Q +Q    ++ +   Q+Q +Q ++A Q  + +QQ +Q QQ+Q+Q   LS
Sbjct: 176 QQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLS 235



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 40/135 (29%), Positives = 70/135 (51%), Gaps = 21/135 (15%)

Query: 454 QAEEVLQKYLKSKESVSHAILQTDQA-------LTETEKKKKEA-------QVKAEAEKA 499
           Q +++LQ+ + S + +  A+LQ  QA       L E  KK++E        Q + + ++ 
Sbjct: 103 QMQQILQQQVLSPQQLQ-ALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQ 161

Query: 500 EAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTF 559
           + Q+    Q+Q +Q  Q++++  Q+Q +Q    KQ   A++Q+ Q+QQ Q+ AAQ    F
Sbjct: 162 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQ---AKEQQQQQQQQQQLAAQ-QLVF 217

Query: 560 QAQ--NRSLLSELQH 572
           Q Q      L + QH
Sbjct: 218 QQQLLQMQQLQQQQH 232



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 33/141 (23%), Positives = 71/141 (50%), Gaps = 11/141 (7%)

Query: 433 LFIQKTEELKAK---YYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKE 489
           L +Q+ + L+A      ++   G+++ +   K    +  VS A++ T Q +T  + ++  
Sbjct: 50  LHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMM-TPQVITPQQMQQIL 108

Query: 490 AQVKAEAEKAEA--QRLAAIQRQNEQMMQ----ERERLHQEQVRQMEIAKQNWLAEQQKM 543
            Q     ++ +A  Q+  A+  Q +Q+ +    ++E+LH + ++Q +  +Q    +QQ+ 
Sbjct: 109 QQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQ-QQQQQQQQQQQQ 167

Query: 544 QEQQMQEQAAQLSTTFQAQNR 564
           Q+QQ Q+Q  Q     Q Q +
Sbjct: 168 QQQQQQQQQQQQQQQQQQQQQ 188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,213,452
Number of Sequences: 37866
Number of extensions: 890430
Number of successful extensions: 12220
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 239
Number of HSP's successfully gapped in prelim test: 692
Number of HSP's that attempted gapping in prelim test: 5800
Number of HSP's gapped (non-prelim): 3425
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.