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Search of human proteins with 158631203
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
(280 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 578 e-165
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 84 1e-16
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 84 1e-16
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 72 5e-13
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 71 9e-13
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 71 9e-13
gi|50234893 pleckstrin homology domain containing, family A (pho... 70 3e-12
gi|31377720 pleckstrin homology domain containing, family A (pho... 70 3e-12
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 64 1e-10
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 64 1e-10
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 64 1e-10
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 64 2e-10
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 62 6e-10
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 62 6e-10
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 62 7e-10
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 62 7e-10
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 62 7e-10
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 62 7e-10
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 62 7e-10
gi|55741447 pleckstrin homology domain containing, family H (wit... 59 4e-09
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 59 5e-09
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 59 5e-09
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 57 2e-08
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 57 2e-08
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 57 2e-08
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 57 2e-08
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 55 9e-08
gi|154146216 pleckstrin homology domain containing, family A (ph... 55 9e-08
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 54 2e-07
gi|217416392 pleckstrin homology domain containing, family H (wi... 54 2e-07
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 578 bits (1491), Expect = e-165
Identities = 280/280 (100%), Positives = 280/280 (100%)
Query: 1 MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLL 60
MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLL
Sbjct: 1 MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLL 60
Query: 61 RDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETG 120
RDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETG
Sbjct: 61 RDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETG 120
Query: 121 TLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT 180
TLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT
Sbjct: 121 TLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT 180
Query: 181 WKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLC 240
WKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLC
Sbjct: 181 WKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLC 240
Query: 241 AKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK 280
AKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
Sbjct: 241 AKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK 280
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/233 (28%), Positives = 116/233 (49%), Gaps = 22/233 (9%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT-GYSFK 93
W+HG +++ A LL++ G S+L+R S+ T G YSL R ++++ F + T F
Sbjct: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
Query: 94 FGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGR- 152
G ++S+ D + H+ + ++ LK P P + +E + ++V T R
Sbjct: 411 MGGRYYNSIGDIIDHYRKEQIVEG-----YYLKEPVPMQDQEQVLNDTVDGKEIYNTIRR 465
Query: 153 -TEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRN--ELKYFK-DQMSPEPIRIL 208
T+D K+GYL K+ G K WK +F L + +L YF+ ++ + +P ++
Sbjct: 466 KTKDAFYKNI----VKKGYLLKK-GKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLI 520
Query: 209 DLTECSA-VQFDYSQERVNCFCLVFPFRT-----FYLCAKTGVEADEWIKILR 255
DL+ CS V D R NCF +V + FY +T +A++W+K L+
Sbjct: 521 DLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 573
Score = 52.0 bits (123), Expect = 6e-07
Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAK-DSVKHFHVEYTGYSFK 93
WYHG L R AE L G GSYL+R+S+ G + LS ++ + V HF + +
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240
Query: 94 FGFNEFSSLKDFVKHFAN 111
G FSSL D + ++++
Sbjct: 241 IGGRRFSSLSDLIGYYSH 258
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/233 (28%), Positives = 116/233 (49%), Gaps = 22/233 (9%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT-GYSFK 93
W+HG +++ A LL++ G S+L+R S+ T G YSL R ++++ F + T F
Sbjct: 174 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
Query: 94 FGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGR- 152
G ++S+ D + H+ + ++ LK P P + +E + ++V T R
Sbjct: 234 MGGRYYNSIGDIIDHYRKEQIVEG-----YYLKEPVPMQDQEQVLNDTVDGKEIYNTIRR 288
Query: 153 -TEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRN--ELKYFK-DQMSPEPIRIL 208
T+D K+GYL K+ G K WK +F L + +L YF+ ++ + +P ++
Sbjct: 289 KTKDAFYKNI----VKKGYLLKK-GKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLI 343
Query: 209 DLTECSA-VQFDYSQERVNCFCLVFPFRT-----FYLCAKTGVEADEWIKILR 255
DL+ CS V D R NCF +V + FY +T +A++W+K L+
Sbjct: 344 DLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 396
Score = 54.3 bits (129), Expect = 1e-07
Identities = 29/79 (36%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 34 GWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAK-DSVKHFHVEYTGYSF 92
GWYHG L R AE L G GSYL+R+S+ G + LS ++ + V HF + +
Sbjct: 3 GWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDY 62
Query: 93 KFGFNEFSSLKDFVKHFAN 111
G FSSL D + ++++
Sbjct: 63 YIGGRRFSSLSDLIGYYSH 81
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 72.0 bits (175), Expect = 5e-13
Identities = 34/94 (36%), Positives = 57/94 (60%), Gaps = 1/94 (1%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
WY+G +TRH AE L G +G +L+RDS + +S+S++A+ KHF V+ +
Sbjct: 282 WYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCI 341
Query: 95 GFNEFSSLKDFVKHFANQPLIGSETG-TLMVLKH 127
G +FS++++ V+H+ P+ SE G L ++KH
Sbjct: 342 GQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKH 375
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 71.2 bits (173), Expect = 9e-13
Identities = 32/91 (35%), Positives = 51/91 (56%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
WY+GN+TRH AE L G +G +L+RDS + +S+S++A KHF V+ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCI 344
Query: 95 GFNEFSSLKDFVKHFANQPLIGSETGTLMVL 125
G F ++ + V+H+ P+ SE G + L
Sbjct: 345 GQRRFHTMDELVEHYKKAPIFTSEHGEKLYL 375
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 71.2 bits (173), Expect = 9e-13
Identities = 32/91 (35%), Positives = 51/91 (56%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
WY+GN+TRH AE L G +G +L+RDS + +S+S++A KHF V+ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCI 344
Query: 95 GFNEFSSLKDFVKHFANQPLIGSETGTLMVL 125
G F ++ + V+H+ P+ SE G + L
Sbjct: 345 GQRRFHTMDELVEHYKKAPIFTSEHGEKLYL 375
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 69.7 bits (169), Expect = 3e-12
Identities = 38/97 (39%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 159 PTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQF 218
P S K GY KQG ++K WK R+F L N + YFK ++ EP+R++ L E VQ
Sbjct: 186 PPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQE 245
Query: 219 DYSQE---RVNCFCLVFPFRTFYLCAKTGVEADEWIK 252
+ R N F +V RTFY+ A + E WIK
Sbjct: 246 CKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIK 282
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 69.7 bits (169), Expect = 3e-12
Identities = 38/97 (39%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 159 PTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQF 218
P S K GY KQG ++K WK R+F L N + YFK ++ EP+R++ L E VQ
Sbjct: 186 PPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQE 245
Query: 219 DYSQE---RVNCFCLVFPFRTFYLCAKTGVEADEWIK 252
+ R N F +V RTFY+ A + E WIK
Sbjct: 246 CKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIK 282
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 64.3 bits (155), Expect = 1e-10
Identities = 31/80 (38%), Positives = 47/80 (58%), Gaps = 1/80 (1%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
WYH +LTR AE +L+ DG++L+R NE Y++S RA+ +KH V+ G +
Sbjct: 668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNS-YAISFRAEGKIKHCRVQQEGQTVML 726
Query: 95 GFNEFSSLKDFVKHFANQPL 114
G +EF SL D + ++ PL
Sbjct: 727 GNSEFDSLVDLISYYEKHPL 746
Score = 47.4 bits (111), Expect = 1e-05
Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 25/173 (14%)
Query: 8 EGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLT-----RHAAEALLL-----SNGCDGS 57
+G ++P ++ S + EL + W+HG L RH AE LL + DGS
Sbjct: 527 QGNEDEEEPKEVSSST----ELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGS 582
Query: 58 YLLRDSNETTGLYSLSVRAKDSVKH--FHVEYTGYSFKFGFNE---FSSLKDFVKHFANQ 112
+L+R+S G Y+LS V+H H + KF + F SL D + H+
Sbjct: 583 FLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQV 642
Query: 113 PLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLG 165
PL +E M L P P + + +ES + A T + ++ P G
Sbjct: 643 PLRCNEFE--MRLSEPVP----QTNAHESKEWYHASLTRAQAEHMLMRVPRDG 689
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 64.3 bits (155), Expect = 1e-10
Identities = 31/80 (38%), Positives = 47/80 (58%), Gaps = 1/80 (1%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
WYH +LTR AE +L+ DG++L+R NE Y++S RA+ +KH V+ G +
Sbjct: 668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNS-YAISFRAEGKIKHCRVQQEGQTVML 726
Query: 95 GFNEFSSLKDFVKHFANQPL 114
G +EF SL D + ++ PL
Sbjct: 727 GNSEFDSLVDLISYYEKHPL 746
Score = 47.4 bits (111), Expect = 1e-05
Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 25/173 (14%)
Query: 8 EGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLT-----RHAAEALLL-----SNGCDGS 57
+G ++P ++ S + EL + W+HG L RH AE LL + DGS
Sbjct: 527 QGNEDEEEPKEVSSST----ELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGS 582
Query: 58 YLLRDSNETTGLYSLSVRAKDSVKH--FHVEYTGYSFKFGFNE---FSSLKDFVKHFANQ 112
+L+R+S G Y+LS V+H H + KF + F SL D + H+
Sbjct: 583 FLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQV 642
Query: 113 PLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLG 165
PL +E M L P P + + +ES + A T + ++ P G
Sbjct: 643 PLRCNEFE--MRLSEPVP----QTNAHESKEWYHASLTRAQAEHMLMRVPRDG 689
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 64.3 bits (155), Expect = 1e-10
Identities = 34/97 (35%), Positives = 57/97 (58%), Gaps = 2/97 (2%)
Query: 34 GWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFK 93
GW+H +L+ AE LL G GS+L R S + G +SLSVR D V H ++ +G +
Sbjct: 5 GWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 64
Query: 94 -FGFNEFSSLKDFVKHFANQP-LIGSETGTLMVLKHP 128
+G +F++L + V+++ Q ++ GT++ LK+P
Sbjct: 65 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 101
Score = 46.2 bits (108), Expect = 3e-05
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 11/105 (10%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKD---------SVKHFHV 85
WYHG+++ AE LL + G ++L+R+S G + LSV + V H V
Sbjct: 112 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 171
Query: 86 EYTGYSFKF-GFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPY 129
G + G F SL D V+HF + I +G + L+ PY
Sbjct: 172 MCEGGRYTVGGLETFDSLTDLVEHF-KKTGIEEASGAFVYLRQPY 215
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 63.5 bits (153), Expect = 2e-10
Identities = 34/96 (35%), Positives = 57/96 (59%), Gaps = 2/96 (2%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTG-YSFK 93
W+H N+T AE LLL+ G DGS+L R S G ++LSVR +V H ++ TG Y
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
Query: 94 FGFNEFSSLKDFVKHF-ANQPLIGSETGTLMVLKHP 128
+G +F++L + V+++ + + + G ++ LK+P
Sbjct: 66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP 101
Score = 58.2 bits (139), Expect = 8e-09
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVR----------AKDSVKHFH 84
W+HG+L+ AE LL G GS+L+R+S G + LSVR K V H
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 85 VEYTGYSFKFGFNE-FSSLKDFVKHFANQPLIGSETGTLMVLKHP 128
+ + G E F SL D V+H+ P++ GT++ LK P
Sbjct: 172 IRCQELKYDVGGGERFDSLTDLVEHYKKNPMV-ETLGTVLQLKQP 215
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 62.0 bits (149), Expect = 6e-10
Identities = 33/96 (34%), Positives = 56/96 (58%), Gaps = 2/96 (2%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFK- 93
W+H +L+ AE LL G GS+L R S + G +SLSVR D V H ++ +G +
Sbjct: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63
Query: 94 FGFNEFSSLKDFVKHFANQP-LIGSETGTLMVLKHP 128
+G +F++L + V+++ Q ++ GT++ LK+P
Sbjct: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99
Score = 46.2 bits (108), Expect = 3e-05
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 11/105 (10%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKD---------SVKHFHV 85
WYHG+++ AE LL + G ++L+R+S G + LSV + V H V
Sbjct: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169
Query: 86 EYTGYSFKF-GFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPY 129
G + G F SL D V+HF + I +G + L+ PY
Sbjct: 170 MCEGGRYTVGGLETFDSLTDLVEHF-KKTGIEEASGAFVYLRQPY 213
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 62.0 bits (149), Expect = 6e-10
Identities = 33/96 (34%), Positives = 56/96 (58%), Gaps = 2/96 (2%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFK- 93
W+H +L+ AE LL G GS+L R S + G +SLSVR D V H ++ +G +
Sbjct: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63
Query: 94 FGFNEFSSLKDFVKHFANQP-LIGSETGTLMVLKHP 128
+G +F++L + V+++ Q ++ GT++ LK+P
Sbjct: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99
Score = 46.2 bits (108), Expect = 3e-05
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 11/105 (10%)
Query: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKD---------SVKHFHV 85
WYHG+++ AE LL + G ++L+R+S G + LSV + V H V
Sbjct: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169
Query: 86 EYTGYSFKF-GFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPY 129
G + G F SL D V+HF + I +G + L+ PY
Sbjct: 170 MCEGGRYTVGGLETFDSLTDLVEHF-KKTGIEEASGAFVYLRQPY 213
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 9/127 (7%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R AAE LLS+ +GS+L+R+S + G S+S+R + V H+ + T
Sbjct: 153 LEKHSWYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTA 147
G + + FS+L + V H + G + L +P P K +P++Y +H
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHST-----VADGLVTTLHYPAP-KCNKPTVYGVSPIHDK 265
Query: 148 MQTGRTE 154
+ RT+
Sbjct: 266 WEMERTD 272
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 9/127 (7%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R AAE LLS+ +GS+L+R+S + G S+S+R + V H+ + T
Sbjct: 168 LEKHSWYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTA 147
G + + FS+L + V H + G + L +P P K +P++Y +H
Sbjct: 227 DGKVYVTAESRFSTLAELVHHHST-----VADGLVTTLHYPAP-KCNKPTVYGVSPIHDK 280
Query: 148 MQTGRTE 154
+ RT+
Sbjct: 281 WEMERTD 287
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 9/127 (7%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R AAE LLS+ +GS+L+R+S + G S+S+R + V H+ + T
Sbjct: 147 LEKHSWYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTA 147
G + + FS+L + V H + G + L +P P K +P++Y +H
Sbjct: 206 DGKVYVTAESRFSTLAELVHHHST-----VADGLVTTLHYPAP-KCNKPTVYGVSPIHDK 259
Query: 148 MQTGRTE 154
+ RT+
Sbjct: 260 WEMERTD 266
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 9/127 (7%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R AAE LLS+ +GS+L+R+S + G S+S+R + V H+ + T
Sbjct: 153 LEKHSWYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTA 147
G + + FS+L + V H + G + L +P P K +P++Y +H
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHST-----VADGLVTTLHYPAP-KCNKPTVYGVSPIHDK 265
Query: 148 MQTGRTE 154
+ RT+
Sbjct: 266 WEMERTD 272
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 9/127 (7%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R AAE LLS+ +GS+L+R+S + G S+S+R + V H+ + T
Sbjct: 132 LEKHSWYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTA 147
G + + FS+L + V H + G + L +P P K +P++Y +H
Sbjct: 191 DGKVYVTAESRFSTLAELVHHHST-----VADGLVTTLHYPAP-KCNKPTVYGVSPIHDK 244
Query: 148 MQTGRTE 154
+ RT+
Sbjct: 245 WEMERTD 251
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 59.3 bits (142), Expect = 4e-09
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 7/92 (7%)
Query: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFK--DQMSPEPIRILDL-TECSAVQFDYSQE 223
K GYL K G VKTWK RWF L + ++ Y+K + +P +DL + C V+ + SQ
Sbjct: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQ- 639
Query: 224 RVNCFCLVFPFRTFYLCAKTGVEADEWIKILR 255
F L+ +T+YL A + +EWI++L+
Sbjct: 640 ---TFQLISEKKTYYLTADSPSLLEEWIRVLQ 668
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 58.9 bits (141), Expect = 5e-09
Identities = 35/112 (31%), Positives = 63/112 (56%), Gaps = 9/112 (8%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R+AAE LLS+G +GS+L+R+S + G S+S+R + V H+ +
Sbjct: 122 LEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIY 139
G + + F++L + V H + G + L +P P++ +P++Y
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHST-----VADGLITTLHYPAPKR-NKPTVY 226
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 58.9 bits (141), Expect = 5e-09
Identities = 35/112 (31%), Positives = 63/112 (56%), Gaps = 9/112 (8%)
Query: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT- 88
L+ WYHG ++R+AAE LLS+G +GS+L+R+S + G S+S+R + V H+ +
Sbjct: 141 LEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 89 -GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIY 139
G + + F++L + V H + G + L +P P++ +P++Y
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHST-----VADGLITTLHYPAPKR-NKPTVY 245
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226
K G+L KQGG VKTW TRWF L ++L YFKD+ +P+ + L + ++E
Sbjct: 22 KCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPG 81
Query: 227 CFCL-VFP----------FRTFYLCAKTGVEADEWIKILR 255
F V P ++ L A T + ++W+K +R
Sbjct: 82 KFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIR 121
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 57.0 bits (136), Expect = 2e-08
Identities = 39/115 (33%), Positives = 50/115 (43%), Gaps = 23/115 (20%)
Query: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226
+EG+L K GG VKTWK RWF L N L YF+ EP I+ L S + D + N
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVD-DPRKPN 320
Query: 227 CFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLS 259
CF L P + + A T E DEWIK ++ +S
Sbjct: 321 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVS 375
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 57.0 bits (136), Expect = 2e-08
Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 10/134 (7%)
Query: 132 KVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRN 191
KVE I S V T Q P K G+L KQ +VK W+ R+F L
Sbjct: 14 KVEAAKIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQ 73
Query: 192 ELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCL-VFPFR---------TFYLCA 241
+L Y+KD+ +P + L C+ + + E F + P ++ L A
Sbjct: 74 QLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMA 133
Query: 242 KTGVEADEWIKILR 255
+ E +EW+K LR
Sbjct: 134 SSQAEMEEWVKFLR 147
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 56.6 bits (135), Expect = 2e-08
Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 23/116 (19%)
Query: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226
+EG+L K GG VKTWK RWF L N L YF+ EP I+ L S + + S ++ N
Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS-KKPN 321
Query: 227 CFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLSQ 260
CF L P + + A T E +EWIK ++ +S+
Sbjct: 322 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 377
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 54.7 bits (130), Expect = 9e-08
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 5 ELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSN 64
E L K T+D L D + ++ WY G + R AE +L S DG++L+R+S+
Sbjct: 593 EWLGIKNETEDQYALMEDED-DLPHHEERTWYVGKINRTQAEEML-SGKRDGTFLIRESS 650
Query: 65 ETTGLYSLSVRAKDSVKH--FHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTL 122
+ G Y+ SV KH + TG+ F +N + SLK+ V H+ + L+
Sbjct: 651 QR-GCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALT 709
Query: 123 MVLKHP 128
+ L HP
Sbjct: 710 VTLAHP 715
Score = 42.0 bits (97), Expect = 6e-04
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 13/97 (13%)
Query: 25 GEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRD-SNETTGLYSLSVRAKDS---V 80
G LQD WY G+++R L DG++L+RD S++ G Y+L++R + +
Sbjct: 320 GSPPSLQDAEWYWGDISREEVNEKLRDTP-DGTFLVRDASSKIQGEYTLTLRKGGNNKLI 378
Query: 81 KHFHVEYTGYSFKFGFNE---FSSLKDFVKHFANQPL 114
K FH + G+ +GF+E F S+ D + H+ ++ L
Sbjct: 379 KVFHRD--GH---YGFSEPLTFCSVVDLINHYRHESL 410
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 54.7 bits (130), Expect = 9e-08
Identities = 36/99 (36%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 160 TAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIR------ILDLTEC 213
T P L K GY KQG + K+WK R+F L + YFK + EP+R +L EC
Sbjct: 195 TGPPL-IKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253
Query: 214 SAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIK 252
D R N F ++ RTFY+ A + + WIK
Sbjct: 254 LVKSGDLLM-RDNLFEIITSSRTFYVQADSPEDMHSWIK 291
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 53.9 bits (128), Expect = 2e-07
Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 10/129 (7%)
Query: 137 SIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYF 196
SI S V T Q P K G+L KQ +VK W+ R+F L +L Y+
Sbjct: 12 SIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYY 71
Query: 197 KDQMSPEPIRILDLTECSAVQFDYSQERVNCFCL-VFPFR---------TFYLCAKTGVE 246
KD+ +P + L C+ + + E F + P ++ L A + E
Sbjct: 72 KDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAE 131
Query: 247 ADEWIKILR 255
+EW+K LR
Sbjct: 132 MEEWVKFLR 140
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 53.5 bits (127), Expect = 2e-07
Identities = 34/92 (36%), Positives = 48/92 (52%), Gaps = 7/92 (7%)
Query: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFK--DQMSPEPIRILDLT-ECSAVQFDYSQE 223
K GYL K G VK+WK RWF L EL Y+K + +P ++L+ CS ++ D Q
Sbjct: 706 KSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQ- 764
Query: 224 RVNCFCLVFPFRTFYLCAKTGVEADEWIKILR 255
L T+YL A + +EWIK+L+
Sbjct: 765 ---TVQLTTEKHTYYLTADSPNILEEWIKVLQ 793
Score = 28.1 bits (61), Expect = 8.9
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 7/107 (6%)
Query: 118 ETGTLMVLKHPYPRKVEEPSIYES-VRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGG 176
+T L KH Y + P+I E ++V + + + L T +G LTK
Sbjct: 764 QTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTK--- 820
Query: 177 LVKTWKTR--WFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYS 221
VK ++ W TL L YF+ Q P+ + L E + D S
Sbjct: 821 -VKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRS 866
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,828,644
Number of Sequences: 37866
Number of extensions: 466692
Number of successful extensions: 1442
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 1131
Number of HSP's gapped (non-prelim): 329
length of query: 280
length of database: 18,247,518
effective HSP length: 101
effective length of query: 179
effective length of database: 14,423,052
effective search space: 2581726308
effective search space used: 2581726308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.