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Search of human proteins with 157743265
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157743265 caspase recruitment domain family, member 11 [Homo
sapiens]
(1154 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157743265 caspase recruitment domain family, member 11 [Homo ... 2301 0.0
gi|51093861 caspase recruitment domain protein 10 [Homo sapiens] 434 e-121
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 434 e-121
gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo... 370 e-102
gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo... 370 e-102
gi|16507955 caspase recruitment domain protein 14 isoform 2 [Hom... 133 1e-30
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 74 8e-13
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 72 3e-12
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 72 4e-12
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 72 4e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 69 2e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 69 3e-11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 69 3e-11
gi|148746195 trichohyalin [Homo sapiens] 68 4e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 68 4e-11
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 67 1e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 1e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 67 1e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 67 1e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 67 1e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 67 1e-10
gi|34577114 cytomatrix protein p110 [Homo sapiens] 67 1e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 2e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 3e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 65 4e-10
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 65 4e-10
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 65 4e-10
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 65 4e-10
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 65 5e-10
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 64 8e-10
>gi|157743265 caspase recruitment domain family, member 11 [Homo
sapiens]
Length = 1154
Score = 2301 bits (5963), Expect = 0.0
Identities = 1154/1154 (100%), Positives = 1154/1154 (100%)
Query: 1 MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV 60
MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV
Sbjct: 1 MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV 60
Query: 61 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV 120
LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV
Sbjct: 61 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV 120
Query: 121 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERY 180
EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERY
Sbjct: 121 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERY 180
Query: 181 YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME 240
YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME
Sbjct: 181 YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME 240
Query: 241 EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA 300
EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA
Sbjct: 241 EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA 300
Query: 301 ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM 360
ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM
Sbjct: 301 ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM 360
Query: 361 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420
YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE
Sbjct: 361 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420
Query: 421 MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTS 480
MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTS
Sbjct: 421 MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTS 480
Query: 481 EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCG 540
EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCG
Sbjct: 481 EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCG 540
Query: 541 SLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALD 600
SLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALD
Sbjct: 541 SLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALD 600
Query: 601 LDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVR 660
LDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVR
Sbjct: 601 LDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVR 660
Query: 661 GPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIR 720
GPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIR
Sbjct: 661 GPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIR 720
Query: 721 GERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRL 780
GERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRL
Sbjct: 721 GERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRL 780
Query: 781 NLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQ 840
NLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQ
Sbjct: 781 NLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQ 840
Query: 841 LLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLL 900
LLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLL
Sbjct: 841 LLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLL 900
Query: 901 QFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSL 960
QFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSL
Sbjct: 901 QFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSL 960
Query: 961 IPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKT 1020
IPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKT
Sbjct: 961 IPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKT 1020
Query: 1021 ETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCE 1080
ETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCE
Sbjct: 1021 ETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCE 1080
Query: 1081 KNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIG 1140
KNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIG
Sbjct: 1081 KNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIG 1140
Query: 1141 EEQRKTIWVDEDQL 1154
EEQRKTIWVDEDQL
Sbjct: 1141 EEQRKTIWVDEDQL 1154
>gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]
Length = 1032
Score = 434 bits (1116), Expect = e-121
Identities = 377/1167 (32%), Positives = 550/1167 (47%), Gaps = 204/1167 (17%)
Query: 18 EEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLL 77
EEDALWE +E RH L+R +NPAKLTPYLRQC+VIDEQDE+EVL+ P ++NR GRL+
Sbjct: 23 EEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLM 82
Query: 78 DILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIK 137
DIL +G+RGY FLE+LEFYYPE + L+TG+EP +R S I+ EEG EGLT FLM EV +
Sbjct: 83 DILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRR 142
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
L++ K++ + +L AR R LE+E+ + + QER +++E+ ++ + EL+++
Sbjct: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRL 202
Query: 198 KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDI 257
KD+NY +AMR AQLSEEKN AV+RSRDLQL +DQLK +++++EEEC L R
Sbjct: 203 KDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAE 262
Query: 258 ENRPKKEQ---------VLELERENEMLKTKNQELQSIIQ--AGKRSLPDSDKAILDILE 306
E +KE+ V EL EN+ L +ELQ +Q A + P S++ +LDILE
Sbjct: 263 EKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILE 322
Query: 307 HDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMN 366
HD +EA + RQEL C+ +++
Sbjct: 323 HDWREAQDSRQEL--------------------------------------CQ----KLH 340
Query: 367 TVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREA 426
V +L+ E RDQ ++ + ++ + D Y+ ++ + + +E IE R +A
Sbjct: 341 AVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEE--IEKERDQA 398
Query: 427 CIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPED 486
S+D L S ++I +D R E D+ T+ S E
Sbjct: 399 I----------QSRDRIQLQYSQ------SLIEKDQYRKQVRGLEAERDELLTTLTSLEG 442
Query: 487 SKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGT---DASPSSCGSLP 543
+K L +QLQRA+ LK + + T PS G
Sbjct: 443 TKALLE------------VQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPE 490
Query: 544 ITNSFTKMQPPRSRSSI-----------MSITAEPPGNDSIVRRYKED--APHRSTVEED 590
T M P +S +SI PP SI+RR +E+ AP + +
Sbjct: 491 ATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSM 550
Query: 591 NDSGGFDALDLDDDSHERYSFGPSSIHSSSSSH---QSEGLDAYDLEQVNLMFRKFSLER 647
+D G L + +S G SS SS S + EGL A L F SL
Sbjct: 551 SDITGSVTL-------KPWSPGLSSSSSSDSVWPLGKPEGLLA---RGCGLDFLNRSL-- 598
Query: 648 PFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLR 707
++ G GP Q +G L+ G G+ V V G + + R
Sbjct: 599 ----AIRVSGRSPPGGPEPQDKGPDG------LSFYGDRWSGAVVRRVLSGPGSARMEPR 648
Query: 708 EGH-QLLLLEG-CIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDM 765
E + LEG C+ E Q L W Q + P + K + + + ++
Sbjct: 649 EQRVEAAGLEGACLEAEAQQRTL--------LWN-QGSTLPSLMDSKAC-QSFHEALEAW 698
Query: 766 EDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDH 825
G + FYIR NL + + D + +K +++ + D+ Y+ R EW C RVDP T
Sbjct: 699 AKG--PGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLR 756
Query: 826 DLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRV 885
DLD GT+P+Y RAQQLL V+ E+ L +S R
Sbjct: 757 DLDRGTVPNYQRAQQLLEVQ-----------------------------EKCLPSSRHR- 786
Query: 886 SPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQ 945
PR N KR + +++R++ P+G+ A S D +LL E
Sbjct: 787 GPR------------------SNLKKR--ALDQLRLVRPKPVGAPAGDSPD--QLLLEPC 824
Query: 946 EELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLN-SGGAMEFTIC 1004
E PE SL PYSLVR RPV+ P LA L++ LL+ ++F +C
Sbjct: 825 AE--PER------SLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVC 876
Query: 1005 KSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDL 1064
++ ++ +E L ++ P I E+V KHCLLE G R+L
Sbjct: 877 PAESLSGEE-LCPSSAPGAPKAQPATPGLGSRIRAIQ-ESVG--KKHCLLELGARGVREL 932
Query: 1065 IKSNIYPIVLFIRVCEKNIKRFRKLLPRPE-TEEEFLRVCRLKEKELEALPCLYATVEPD 1123
+++ IYPIV+ + V EKN++ R LL RP + E LR CR E+ L LPC + V
Sbjct: 933 VQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAH 992
Query: 1124 MWGSVEELLRVVKDKIGEEQRKTIWVD 1150
WG EEL +VV+ +I +EQ + +WV+
Sbjct: 993 EWGHAEELAKVVRGRILQEQARLVWVE 1019
>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
sapiens]
Length = 1004
Score = 434 bits (1115), Expect = e-121
Identities = 341/1147 (29%), Positives = 548/1147 (47%), Gaps = 173/1147 (15%)
Query: 18 EEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLL 77
+E+ LWE +E +RH + R I P++LTPYLRQ KV+ + DE+EVL++P L + RAG LL
Sbjct: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
Query: 78 DILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIK 137
D+L T+G+ G + FLESL+F+ P++Y LVTG +P FS LT L +
Sbjct: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVE-LLTFQERYYKMKEERDSYNDELVK 196
LQ+++ + Q+ LL R +QL+ E + TR E L + + +MK E ++ E+++
Sbjct: 135 LQEELNQEKGQKEVLLRRCQQLQ-EHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLR 193
Query: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNK--MEEECKLE-RNQSLKL 253
+KD+ +L++ Y+ +EK +A R R LQ E+ LK L + M C+LE + QSL+
Sbjct: 194 LKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRT 253
Query: 254 KNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEAL 313
+D E+ E++ L+ ENE L++ L A DILE EA
Sbjct: 254 ASDQES--GDEELNRLKEENEKLRSLTFSL----------------AEKDILEQSLDEAR 295
Query: 314 EDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLE 373
RQELV RI++L+E A AE R++Y EEKE L+ C++Y+ ++N + Q+
Sbjct: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
Query: 374 EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLES 433
E+++ERDQA+ +RD AQ + SQ L+EKD R+Q+ EL ++ + L +
Sbjct: 356 ELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQ--------------VCELRT 401
Query: 434 KLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPY 493
+LR+L + P ++ Q ++ T E P + + +
Sbjct: 402 QLRQLQAE------------PPGVLKQ---------------EARTREPCPREKQRLVRM 434
Query: 494 HPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQP 553
H I + SD E + S+ S + +SF P
Sbjct: 435 H------------------AICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSP 476
Query: 554 PRSRSSIMSITAEPPGNDSIVRRYKEDAPHR-----STVE-EDNDSGGFDALDLDDDSHE 607
PP S+ +R ED S +E + D G D +
Sbjct: 477 ------------APPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLD 524
Query: 608 RYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQ 667
+ + SS Q D+ + ++ R+ RP R ++ V +
Sbjct: 525 YELLDTADLPQLESSLQPVSPGRLDVSESGVLMRR----RPARRILSQVTML-------- 572
Query: 668 HTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVP 727
GD+L Q++++GGN G F+H V PGS A++ LR G Q+++++
Sbjct: 573 --AFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAV 630
Query: 728 LDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQ 787
L+ T EEA ++R G L KVN +GY++L++D+E + TSGDSFYIR+NL + +
Sbjct: 631 LEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGR 690
Query: 788 LDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDM-GTIPSYSRAQQLLLVKL 846
+ + C++V+HV DTM+Q W RV+ +T D GTIP+YSRAQQ L+ +
Sbjct: 691 AKG-ELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALI 749
Query: 847 QRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRS 906
Q + + T +P S+ P+ +L++ VS
Sbjct: 750 QDMTQQ---------------CTVTRKP----SSGGPQ-------------KLVRIVSMD 777
Query: 907 ENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLV 966
+ K SPL R S D +L + E L+L+PY+LV
Sbjct: 778 KAK--------------ASPL----RLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLV 819
Query: 967 RAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYS 1026
R RPVL P + K L ++L G F C ++ ++++E+ + II
Sbjct: 820 WPHRPARPRPVLLVPRAVGKILSEKLCLLQG---FKKCLAEYLSQEEYEAWSQRGDII-- 874
Query: 1027 REKNPNAFEC-IAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKR 1085
+E + C + +E++ KN H LL+ + L + +I+PIV+ + V EK K+
Sbjct: 875 QEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKK 934
Query: 1086 FRKLLPRPET-EEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQR 1144
+K L R T EE+ L R +E +L+ PCLY+++ PD W ++ LL V+ I +EQ+
Sbjct: 935 LKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQK 994
Query: 1145 KTIWVDE 1151
K +W ++
Sbjct: 995 KVVWTEQ 1001
>gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo
sapiens]
Length = 492
Score = 370 bits (949), Expect = e-102
Identities = 206/480 (42%), Positives = 304/480 (63%), Gaps = 33/480 (6%)
Query: 8 MDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLP 67
M DY + +D W +E R L+ I+P+++TPYLRQCKV++ DE++VL+ P L
Sbjct: 1 MSDY-----ENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLV 55
Query: 68 SKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGL 127
+ + G LLDIL G +GYV FLESLE YYP+LYK VTGKEP R FS I+ G GL
Sbjct: 56 IRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGL 115
Query: 128 THFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEER 187
T LM EV+KLQ++++ +L A L +D K++ + L QER ++KEE
Sbjct: 116 TQLLMTEVMKLQKKVQ-------DLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEEC 168
Query: 188 DSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLER 247
++ + EL + K++NY+LAMR A SEEK A+MR+RDLQLEIDQLKH L K E++CK+ER
Sbjct: 169 EAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVER 228
Query: 248 NQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEH 307
+LKL++ +E RP +E + EL++E +L+ + QEL++ +Q GK D + +LE
Sbjct: 229 KHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKL---DRSSPYIQVLEE 285
Query: 308 DRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNT 367
D ++AL D QE N I++L+++ RQ E R + +EEKE EL+C L KD +MYK R+
Sbjct: 286 DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEA 345
Query: 368 VMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREAC 427
++LQ+EEV ERDQA +R+E Q+++ L EKD RKQ+REL EK DE+++++ + EA
Sbjct: 346 ILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ 405
Query: 428 IVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTN-----GQEADDSSTSEE 482
++ +E +LRR + L ++S D D SPR + Q+ +D+ S++
Sbjct: 406 LLAVEGRLRR-------------QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDK 452
>gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo
sapiens]
Length = 536
Score = 370 bits (949), Expect = e-102
Identities = 206/480 (42%), Positives = 304/480 (63%), Gaps = 33/480 (6%)
Query: 8 MDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLP 67
M DY + +D W +E R L+ I+P+++TPYLRQCKV++ DE++VL+ P L
Sbjct: 1 MSDY-----ENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLV 55
Query: 68 SKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGL 127
+ + G LLDIL G +GYV FLESLE YYP+LYK VTGKEP R FS I+ G GL
Sbjct: 56 IRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGL 115
Query: 128 THFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEER 187
T LM EV+KLQ++++ +L A L +D K++ + L QER ++KEE
Sbjct: 116 TQLLMTEVMKLQKKVQ-------DLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEEC 168
Query: 188 DSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLER 247
++ + EL + K++NY+LAMR A SEEK A+MR+RDLQLEIDQLKH L K E++CK+ER
Sbjct: 169 EAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVER 228
Query: 248 NQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEH 307
+LKL++ +E RP +E + EL++E +L+ + QEL++ +Q GK D + +LE
Sbjct: 229 KHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKL---DRSSPYIQVLEE 285
Query: 308 DRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNT 367
D ++AL D QE N I++L+++ RQ E R + +EEKE EL+C L KD +MYK R+
Sbjct: 286 DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEA 345
Query: 368 VMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREAC 427
++LQ+EEV ERDQA +R+E Q+++ L EKD RKQ+REL EK DE+++++ + EA
Sbjct: 346 ILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ 405
Query: 428 IVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTN-----GQEADDSSTSEE 482
++ +E +LRR + L ++S D D SPR + Q+ +D+ S++
Sbjct: 406 LLAVEGRLRR-------------QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDK 452
>gi|16507955 caspase recruitment domain protein 14 isoform 2 [Homo
sapiens]
Length = 434
Score = 133 bits (334), Expect = 1e-30
Identities = 124/484 (25%), Positives = 202/484 (41%), Gaps = 110/484 (22%)
Query: 239 MEEECKLE-RNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDS 297
M C+LE + QSL+ +D E+ E++ L+ ENE L++ L
Sbjct: 1 MVSSCELELQEQSLRTASDQESGD--EELNRLKEENEKLRSLTFSL-------------- 44
Query: 298 DKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKD 357
A DILE EA RQELV RI++L+E A AE R++Y EEKE L+
Sbjct: 45 --AEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMA 102
Query: 358 CEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEM 417
C++Y+ ++N + Q+ E+++ERDQA+ +RD AQ + SQ L+EKD R+Q+ EL ++
Sbjct: 103 CQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQ---- 158
Query: 418 RIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDS 477
+ L ++LR+L + P ++ Q ++
Sbjct: 159 ----------VCELRTQLRQLQAE------------PPGVLKQ---------------EA 181
Query: 478 STSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPS 537
T E P + + + H I + SD E + S
Sbjct: 182 RTREPCPREKQRLVRMH------------------AICPRDDSDCSLVSSTESQLLSDLS 223
Query: 538 SCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHR-----STVE-EDN 591
+ S + +SF P PP S+ +R ED S +E +
Sbjct: 224 ATSSRELVDSFRSSSP------------APPSQQSLYKRVAEDFGEEPWSFSSCLEIPEG 271
Query: 592 DSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRP 651
D G D + + + SS Q D+ + ++ R+ RP R
Sbjct: 272 DPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRR----RPARR 327
Query: 652 SVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQ 711
++ V + GD+L Q++++GGN G F+H V PGS A++ LR G Q
Sbjct: 328 ILSQVTML----------AFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQ 377
Query: 712 LLLL 715
++++
Sbjct: 378 IVMV 381
Score = 31.2 bits (69), Expect = 5.9
Identities = 39/198 (19%), Positives = 88/198 (44%), Gaps = 16/198 (8%)
Query: 174 LTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEK--NMAVMRSRDLQLEIDQ 231
L QE+ + +++S ++EL ++K++N L L+E+ ++ +R + E+ +
Sbjct: 7 LELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVE 66
Query: 232 LKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGK 291
H L + + +R Q + +KEQ L ++++M +E + +QA
Sbjct: 67 RIHSLRERAVAAERQREQYWE---------EKEQTLLQFQKSKMACQLYREKVNALQAQV 117
Query: 292 RSLP---DSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAE-ELRDKYLEEKEDL 347
L D + D + + ++L ++ L +++ L ++ + +LR E L
Sbjct: 118 CELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVL 177
Query: 348 ELKCSTLGKDCEMYKHRM 365
+ + T + C K R+
Sbjct: 178 KQEART-REPCPREKQRL 194
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 73.9 bits (180), Expect = 8e-13
Identities = 83/332 (25%), Positives = 159/332 (47%), Gaps = 39/332 (11%)
Query: 131 LMNEVIKLQQ---QMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEER 187
LM EV L++ +M+ KD + + ++ R+L + ++ EL E+ K E
Sbjct: 376 LMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL 435
Query: 188 DSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME-EECKLE 246
+ + K K + L + L +EKN+ ++DL E++ +K R+ ++E E +LE
Sbjct: 436 EKLEEAFSKSKSECTQL---HLNLEKEKNL----TKDLLNELEVVKSRVKELECSESRLE 488
Query: 247 RNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILE 306
+ + L LK+D+ +L ER+N M K K +E + + ++ ++D+ E
Sbjct: 489 KAE-LSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERK--VDGLNKNFKVEQGKVMDVTE 545
Query: 307 ---HDRKEALEDRQELVNRIYNLQEEARQAEELRDKY-LEEKEDLELKCSTLGKDCEMYK 362
+ K+ L+ + E+ ++YNL R+ +EL K EE++ EL CS ++ K
Sbjct: 546 KLIEESKKLLKLKSEMEEKVYNL---TRERDELIGKLKSEEEKSSELSCSV-----DLLK 597
Query: 363 HRMNTVMLQLEEVERERDQAFHSRDEAQT-----QYSQCLIEKDKYRKQIRELEEKNDEM 417
R++ + EEVERE + + T + + +E ++ +K++++LE +
Sbjct: 598 KRLDGI----EEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLE----VV 649
Query: 418 RIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
++++ E LE K R +N L Q L
Sbjct: 650 EGDLMKTEDEYDQLEQKFRTEQDKANFLSQQL 681
Score = 57.0 bits (136), Expect = 1e-07
Identities = 80/373 (21%), Positives = 158/373 (42%), Gaps = 41/373 (10%)
Query: 109 KEPTRRF--STIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQM 166
KE RR ++ E+ H + L NE K M D LE E++
Sbjct: 159 KETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSD-------DFTNLLEQERE-- 209
Query: 167 TLTRVELLTFQERYYKMKEERDS------YNDELVKVKDDNYNLAMRYAQLSEEKNMAVM 220
R++ L QE+ Y+ ++E+++ DELVK+K L E+ +
Sbjct: 210 ---RLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
Query: 221 RSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKN 280
+ +DL ++ + + +L + + K +R + LKL+ D E++ + +E+E + K
Sbjct: 267 KVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASR-----FSQEHEEMNAKL 321
Query: 281 QELQSIIQAGKRSLPDSDKAILDILEHDR--KEALEDRQELVNRIYNLQ----EEARQAE 334
+S + + L + I ++ E ++ ++A E+ QEL ++I + + E
Sbjct: 322 ANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVE 381
Query: 335 ELRDKYLE-EKEDLEL-----KCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDE 388
LR + LE E +D E+ +C L K + +H + L++E++++ + +
Sbjct: 382 NLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEA 441
Query: 389 AQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQS 448
S+C K+ ++ +E+ + R + LE RL K +L
Sbjct: 442 FSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSR----VKELECSESRLEKAELSLKDD 497
Query: 449 LPRNLPVTIISQD 461
L + T++ D
Sbjct: 498 LTKLKSFTVMLVD 510
Score = 38.5 bits (88), Expect = 0.037
Identities = 35/168 (20%), Positives = 83/168 (49%), Gaps = 17/168 (10%)
Query: 141 QMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKD- 199
++K L+ L RL+QLE + + T E ++++ +++ + + +L ++K
Sbjct: 628 KIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQ 687
Query: 200 -------DNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHR----LNKMEEECKLERN 248
+ + + A+L + +SRDL+ E+ LK + +NK ++ +L+ +
Sbjct: 688 IAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVD 747
Query: 249 QSLK----LKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKR 292
S+ ++ + +N+ ++VL L +E E+ K ++ L+ + G+R
Sbjct: 748 YSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVN-GRR 794
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 72.0 bits (175), Expect = 3e-12
Identities = 99/405 (24%), Positives = 173/405 (42%), Gaps = 49/405 (12%)
Query: 75 RLLDILHTKGQRGYVVF--------LESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEG 126
+LL++L +KG L E + L L+ KE + ++++ EE H
Sbjct: 311 KLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE---KENSMLREEMHRR 367
Query: 127 LTHFLMNEVIK-LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKE 185
+ + K LQ ++ KD + + LR LE+E + + +E K E
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
Query: 186 ERDSYNDELV-KVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEEC- 243
S++ + KV+ L+ + AQ E K A LQ EI Q+K L++ + E
Sbjct: 428 VYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAA----GLQAEIGQVKQELSRKDTELL 483
Query: 244 ----KLER--NQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDS 297
KLE NQ K IE KE + E+ +L+T+ L+ ++ + L
Sbjct: 484 ALQTKLETLTNQFSDSKQHIE--VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKK 541
Query: 298 DKAILDILE---------HDRKEALEDRQELVN----RIYNLQEEARQAEELRDKYLEEK 344
K I D+ E HD K+ L+ ++ VN +I NLQE+ R E+ +
Sbjct: 542 TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK-------QM 594
Query: 345 EDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYR 404
L+ + +L D + T+ L E ER ++ RD + + + E D Y+
Sbjct: 595 SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE---EIDNYK 651
Query: 405 KQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
K +++L+EK ++ ++ +EA +++L+ L+ D L
Sbjct: 652 KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 696
Score = 54.3 bits (129), Expect = 7e-07
Identities = 103/477 (21%), Positives = 195/477 (40%), Gaps = 59/477 (12%)
Query: 8 MDDYMETLKDE---EDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAP 64
M + +E LK+E ++A WE ++ L I K + +++ Q + E L
Sbjct: 436 MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495
Query: 65 MLPSKINRAGRLLDILHTKGQRGYVVFLE--SLEFYYPELYKLVTGKEPTRRFSTIVVEE 122
SK L + L K QR ++ E +L E ++ K T++ + E+
Sbjct: 496 FSDSK-QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKK--TKQIQDMAEEK 552
Query: 123 G---------------HEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMT 167
G E + L ++ LQ+Q++ K+ Q L R++ L+ +
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 168 L---TRVELLTFQERYY-KMKEERDSYNDELVKVKD-DNYNLAMRYAQLSEEKNMAVMRS 222
T E L +ER ++KE+RD DE K ++ DNY ++ L E+ ++
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRD--RDEREKQEEIDNYKKDLK--DLKEKVSLLQGDL 668
Query: 223 RDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQE 282
+ + + LK + + L+++ LK +I KKE+ L++E +++ K
Sbjct: 669 SEKEASLLDLKEHASSLASS-GLKKDSRLKTL-EIALEQKKEECLKME--SQLKKAHEAA 724
Query: 283 LQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQEL------VNRIYNLQEEARQAEEL 336
L++ R+ P+ D ++H +E + E V+R+ + +E +
Sbjct: 725 LEA------RASPEMS----DRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 774
Query: 337 RDKYLEEKE----DLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQ 392
+DK + E E D K + L K E + + + ML EE R D S + Q
Sbjct: 775 KDKKIAELERQVKDQNKKVANL-KHKEQVEKKKSAQML--EEARRREDNLNDSSQQLQDS 831
Query: 393 YSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ ++ + +RE + E + + + E+ N E ++ L + Q L
Sbjct: 832 LRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Score = 48.1 bits (113), Expect = 5e-05
Identities = 65/352 (18%), Positives = 148/352 (42%), Gaps = 56/352 (15%)
Query: 133 NEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYND 192
N ++ LQ Q+K + L+ +LL + ++++ K ++ ++ E +K+ER D
Sbjct: 149 NTIMDLQTQLK-EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE----LKKERALRKD 203
Query: 193 ELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLK 252
E K+ + + R +Q E ++ + +++E +++R+ +
Sbjct: 204 EASKI------------------TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQL 245
Query: 253 LKNDIENRPKKEQVLELERENE---------------MLKTKNQELQSIIQAGKRSLPDS 297
+ D +R + V EL EN +L+ +E++ I+ K++L
Sbjct: 246 FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
Query: 298 DKAILDILE---------------HDRKEALEDRQELVNRIYNLQEEARQAEE-LRDKYL 341
D++I +LE H+R L + + V+ + +L E+ + LR++
Sbjct: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 342 EEKEDL--ELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE 399
E+ K L EM +++++ L ++E E + + + + + +
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 400 KDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+ YR + ++ K ++++ E+ +EA L+ K L + + Q L R
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
Score = 40.4 bits (93), Expect = 0.010
Identities = 44/247 (17%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 178 ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLN 237
+R ++ E Y DE K + + L ++ EKN D +I +L+ ++
Sbjct: 735 DRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN-------DKDKKIAELERQVK 787
Query: 238 KMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDS 297
++ +LK K +E + + + E R + L +Q+LQ ++ + +
Sbjct: 788 DQNKKV-----ANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 298 DKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKD 357
++A+ + ++ + + QE R N +++ + +K +E E ++ K S+ +
Sbjct: 843 EEALRESVQITAEREMVLAQEESART-NAEKQVEELLMAMEKVKQELESMKAKLSSTQQS 901
Query: 358 CEMYKHRMNTVMLQ----LEEVERERDQAF---HSRDEAQTQYSQCLIEKDKYRKQIREL 410
+ + + + LEEV + +A S +A + K K ++++ L
Sbjct: 902 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAAL 961
Query: 411 EEKNDEM 417
+ + D +
Sbjct: 962 KREKDRL 968
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 71.6 bits (174), Expect = 4e-12
Identities = 77/379 (20%), Positives = 175/379 (46%), Gaps = 46/379 (12%)
Query: 99 YPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQ 158
Y E KL + K+ R + + + + + L + +L+++++ ++ + L +L
Sbjct: 691 YEENNKLSSEKKQLSRDLEVFLSQKEDVI---LKEHITQLEKKLQLM-VEEQDNLNKL-- 744
Query: 159 LEDEKKQMTLTRVELLTFQERY----YKMKEERDSYN------DELVKVKDDNYNLAMRY 208
LE+E+ Q + +L F + + EE+D N + L K+ ++ NLA +
Sbjct: 745 LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR 804
Query: 209 AQ--LSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQV 266
+ L EK + ++ + ++ ++LK L E+E L R + ++++ E + +
Sbjct: 805 DEKVLELEKEIKCLQEESV-VQCEELKSLLRDYEQEKVLLRKELEEIQS--EKEALQSDL 861
Query: 267 LELERENEMLKTKNQEL----QSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNR 322
LE++ NE + +NQ L + + Q +S ++K I EH+ + L +++EL +R
Sbjct: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921
Query: 323 ---IYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERER 379
+ L++ ++ +++ L ++LE K L K+C+ + ++N + L + ++E
Sbjct: 922 RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 380 DQAFHSRDEAQTQYSQCLIEKDK--------------YRKQIRELEEKNDEMRIEMVRRE 425
D + + + EKD+ Y+ + E E++++++ +E R
Sbjct: 982 DSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERAN 1041
Query: 426 ACIVNLESKLRRLSKDSNN 444
N E ++ L++ N
Sbjct: 1042 ----NFEHRIEDLTRQLRN 1056
Score = 53.5 bits (127), Expect = 1e-06
Identities = 88/459 (19%), Positives = 187/459 (40%), Gaps = 75/459 (16%)
Query: 7 EMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVL----- 61
++D + K+ L +E N + IN L L Q K I +++ E++
Sbjct: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNIN--SLQEELLQLKAIHQEEVKELMCQIEA 261
Query: 62 NAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVE 121
+A ++IN+ L + L + + + E L K + + +I+++
Sbjct: 262 SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321
Query: 122 EGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYY 181
E ++NE +K LED K++ + ++
Sbjct: 322 ENT--FVEQVVNEKVK--------------------HLEDTLKEL----------ESQHS 349
Query: 182 KMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEE 241
+K+E N+ +K++ D ++ + E DL+ +I++L L K E+
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE----------DLEFKINELL--LAKEEQ 397
Query: 242 ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
C +E KLK+++ K+ + E+ K Q + I + + L DS+K
Sbjct: 398 GCVIE-----KLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK 452
Query: 302 LDILEHDRKEALEDRQELVNRIYNLQEEARQA----EELRDKYLEEKEDLELKCSTLGKD 357
L ++ + Q L + NLQ+E ++A E LR+ + +L + ++
Sbjct: 453 LTLMF--------EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQE 504
Query: 358 CEMYKHRMNTVMLQLEEVER----ERDQAFHSRDEAQTQYSQCLIEKD---KYRKQIREL 410
E K + + + +L++ R E+D + + Q + + L +++ + I+ L
Sbjct: 505 FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
Query: 411 EEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+EKN + + +R+ + LE K+ L+++ ++ L
Sbjct: 565 QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKL 603
Score = 47.8 bits (112), Expect = 6e-05
Identities = 80/369 (21%), Positives = 157/369 (42%), Gaps = 65/369 (17%)
Query: 137 KLQQQMKAKDLQRCELLARLRQLEDEKKQMTLT----RVELLTFQERYYKMKEE------ 186
K+ + + AK+ Q C + +L KQ T E+ + +E++ K E
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
Query: 187 RDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLN----KMEEE 242
DS ++L + + L + L +EK A++ L+ ++ L+ L K+ +E
Sbjct: 446 SDSEKEKLTLMFEIQ-GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQE 504
Query: 243 CKLERNQSLKLKNDIENR-----PKKEQVLE----LERENEMLKTKNQ---ELQSIIQAG 290
+ + Q ++++ + +K+ +LE L+ ENE L ++ + EL++ I+
Sbjct: 505 FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
Query: 291 KR-------SLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEE 343
+ SL D +L LE E++ + +N++ N EE K E
Sbjct: 565 QEKNGVYLLSLSQRD-TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH----KKCER 619
Query: 344 KEDLELKCSTLGKDCEM-------YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQC 396
+E L L+ LGK E + ++N + LEE +E+DQ ++ Q
Sbjct: 620 EERLILE---LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL 676
Query: 397 LIEKDKYRKQIRELEEKNDEMRIEM----------------VRREACIVNLESKLRRLSK 440
+K+ +++ L E+N+++ E V + I LE KL+ + +
Sbjct: 677 SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736
Query: 441 DSNNLDQSL 449
+ +NL++ L
Sbjct: 737 EQDNLNKLL 745
Score = 47.8 bits (112), Expect = 6e-05
Identities = 63/328 (19%), Positives = 138/328 (42%), Gaps = 60/328 (18%)
Query: 131 LMNEVIKLQQQMKAKD--LQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERD 188
L ++ L+++ K K+ + + +L+A KK++ +R E T +E ++ E+D
Sbjct: 949 LEEKIENLEKECKEKEEKINKIKLVA-----VKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 189 SYND---ELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKL 245
+ +L++ + NL + Y + SE+ ++ R+ + + I+ L +L +C+
Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 246 ERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDIL 305
+ + L IE ++LE++ IL
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQ---------------------------------IL 1090
Query: 306 EHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRM 365
E R +A+ D++ L+ E Q E+ ++ +LE L K+ K ++
Sbjct: 1091 EVQRAKAMVDKE--------LEAEKLQKEQKIKEHATTVNELEELQVQLQKE----KKQL 1138
Query: 366 NTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE-KDKYRKQIRELEEKNDEMRIEMVRR 424
M +LE V+++ Q E Y + + E K + ++E+ E++I+ ++
Sbjct: 1139 QKTMQELELVKKDAQQTTLMNMEI-ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
Query: 425 EAC---IVNLESKLRRLSKDSNNLDQSL 449
E I +L+S +++ + + + Q L
Sbjct: 1198 ETLQEEITSLQSSVQQYEEKNTKIKQLL 1225
Score = 43.9 bits (102), Expect = 9e-04
Identities = 47/230 (20%), Positives = 103/230 (44%), Gaps = 27/230 (11%)
Query: 121 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLED------EKKQMTLT----R 170
E H L L E+ QQQ++ +Q E+ + ++ + E+ Q TL+ R
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 171 VELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRD-LQLEI 229
V L + R K ++ + E KV+ N + +S+ + + R+ L++ I
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLI 1358
Query: 230 DQLKHRLN----------------KMEEECKLERNQSLKLKNDIENRPKKEQVLELEREN 273
DQLK +L + E + LER+ + + + +E++ ++ EN
Sbjct: 1359 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1418
Query: 274 EMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRI 323
M+K+++ + S + + L +S + + L+ + ++ +E Q+ ++++
Sbjct: 1419 MMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKM 1468
Score = 37.0 bits (84), Expect = 0.11
Identities = 54/286 (18%), Positives = 124/286 (43%), Gaps = 26/286 (9%)
Query: 162 EKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMR 221
+ K TL + +L+ F ++ + ++ S EL K ++ +R ++E +
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEE-----LRSKPVTEGTGDII-- 71
Query: 222 SRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKK--EQVLELERENEMLKTK 279
+ L +D L + E++C + +++K+K ++E+ K + ELE+ + +
Sbjct: 72 -KALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE 130
Query: 280 NQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDK 339
+ L++ + A RS DKA L+ +EA+ + EL ++ ++L+++
Sbjct: 131 IENLKNELMA-VRSKYSEDKA---NLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186
Query: 340 YLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE 399
+ + E + L K + + QL+ + Q H + + + L
Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQ--HYQKNINSLQEELLQL 244
Query: 400 KDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNL 445
K ++++++EL M + EA E+++ +L++ NL
Sbjct: 245 KAIHQEEVKEL----------MCQIEASAKEHEAEINKLNELKENL 280
Score = 36.6 bits (83), Expect = 0.14
Identities = 47/203 (23%), Positives = 91/203 (44%), Gaps = 22/203 (10%)
Query: 263 KEQVLELERENEMLKTK--NQELQSIIQAGKRSLPDSDKAILDILEHD------RKEALE 314
K + ELE+E E L++K + II+A L D +L+ E + +KE ++
Sbjct: 45 KSRCTELEKEIEELRSKPVTEGTGDIIKALTERL---DALLLEKAETEQQCLSLKKENIK 101
Query: 315 DRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEE 374
+QE+ + + + + ++ E+ Y++E E+L+ + + Y + QLEE
Sbjct: 102 MKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVR---SKYSEDKANLQKQLEE 158
Query: 375 -----VERERDQAFHSRDEAQTQYSQCLIEKDK--YRKQIRELEEKNDEMRIEMVRREAC 427
+E F + E + Q IEK + + +QI L+++ D E
Sbjct: 159 AMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ 218
Query: 428 IVN-LESKLRRLSKDSNNLDQSL 449
+ N +E+ + K+ N+L + L
Sbjct: 219 LQNIIEANSQHYQKNINSLQEEL 241
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 71.6 bits (174), Expect = 4e-12
Identities = 81/386 (20%), Positives = 159/386 (41%), Gaps = 44/386 (11%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQ-LEDEKKQMTLTRVELLTFQERYYKMKEERDS 189
L +V KL+Q+++ + E L ++ + E + L R +++ ++K E D
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
Query: 190 YNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
Y +EL K++ + L + M L + +DQ K L K K
Sbjct: 995 YKEELSKMEKE-------IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKL 1047
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKN-----QELQSIIQAGKRSLPDSDKAILDI 304
+ ++ +K +VLE E +N + K+ QEL+ ++Q + SL + I D+
Sbjct: 1048 QHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDL 1107
Query: 305 ----------LEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTL 354
+E ++E LE Q L R + L++ A Q L E + ++E K L
Sbjct: 1108 TAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKL 1167
Query: 355 G----------KDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYR 404
K+C +N + +E RE++ ++ + SQ E ++ +
Sbjct: 1168 EGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQ---EISQLKKEIERTQ 1224
Query: 405 KQIRELEE--KNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD------QSLPRNLPVT 456
++++E+E K E I +EA + E +L R +++ + Q + +
Sbjct: 1225 QRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIE 1284
Query: 457 IISQDFGDASPRTNGQEADDSSTSEE 482
+S + D + ++A + +EE
Sbjct: 1285 RLSSELEDMKQLSKEKDAHGNHLAEE 1310
Score = 51.6 bits (122), Expect = 4e-06
Identities = 87/460 (18%), Positives = 189/460 (41%), Gaps = 62/460 (13%)
Query: 48 QCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPEL-YKLV 106
Q ++I E+ ++ N+ L S++ + L L + + V + S+ EL +L+
Sbjct: 670 QFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY-SSIAAKNAELEQELM 728
Query: 107 TGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKA-KDLQRCE--LLARLRQLEDEK 163
E R T + E + F + I L+Q + K ++R E L + +Q ++++
Sbjct: 729 EKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
Query: 164 KQMTLTRVELLTFQ-----------ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLS 212
K M++ + +++ Q E +MK+E ++ L +++ ++ QL
Sbjct: 789 KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD 848
Query: 213 EEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ------SLKLKNDIENRPKKEQV 266
+ +L L ++QL+ K E++ K + + LK+KN ++ V
Sbjct: 849 SALEIC---KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNV 905
Query: 267 L---ELERENEMLK-------------TKNQELQSIIQAGKRSLPDSDKAILDILEHDRK 310
+ L+++ +ML+ TK ++ S ++ + +S L +E +
Sbjct: 906 ILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCE 965
Query: 311 EALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCE---MYKHRMNT 367
A + ++ L ARQ + D+Y EE +E + L +D E M+ +++
Sbjct: 966 SAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDM 1025
Query: 368 VMLQLE------------------EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRE 409
++ Q + E E +A R+ +T+ E +Q++E
Sbjct: 1026 ILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQE 1085
Query: 410 LEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
L + + ++ + + I +L ++LR + + Q L
Sbjct: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
Score = 47.0 bits (110), Expect = 1e-04
Identities = 55/288 (19%), Positives = 126/288 (43%), Gaps = 32/288 (11%)
Query: 182 KMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEE 241
KM + E+ +++ L + A L + + + + + E+ Q + +++ +E
Sbjct: 219 KMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES 278
Query: 242 ------ECKLERNQSLKLKNDIENRPK--KEQVLELERENEMLKTKNQELQSIIQAGKRS 293
+ Q + L+ ++ + K +E +LE+ +M+ K Q LQ S
Sbjct: 279 AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQE-------S 331
Query: 294 LPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLE-------EKED 346
+ K +D+LE ++ +RQ +YN +E ++ ++ + K E E+E
Sbjct: 332 KEECIKLKVDLLEQTKQGKRAERQRN-EALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390
Query: 347 LELKCSTLGKD-------CEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE 399
LE + K+ C +YK + + +L +++ E + + S+ + +
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450
Query: 400 KDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLR-RLSKDSNNLD 446
+ R+ I +LE + E + E++R + ++N +L+ R++ + LD
Sbjct: 451 LTESRQSILKLESEL-ENKDEILRDKFSLMNENRELKVRVAAQNERLD 497
Score = 41.2 bits (95), Expect = 0.006
Identities = 47/212 (22%), Positives = 99/212 (46%), Gaps = 20/212 (9%)
Query: 256 DIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED 315
D E + +E++ +L ++N L T+N L + ++ L S +A + +LE +++A
Sbjct: 228 DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASV 286
Query: 316 RQELVNRIYNLQEEA-------RQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTV 368
L +I NL+ E R+AE ++ + + E ++C K +
Sbjct: 287 -PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
Query: 369 MLQLEEVERERDQAFHSRDE---AQTQYSQCLIEK--------DKYRKQIRELEEKNDEM 417
Q + ER+R++A ++ +E A QY + + EK + + + E++N +
Sbjct: 346 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRL 405
Query: 418 RIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ ++ + L+ KLR+L +++NN + L
Sbjct: 406 QERCGLYKSELEILKEKLRQLKEENNNGKEKL 437
Score = 39.7 bits (91), Expect = 0.017
Identities = 64/321 (19%), Positives = 141/321 (43%), Gaps = 37/321 (11%)
Query: 35 RYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLE- 93
+Y LT LR+CK+ E + E+L + N K + V L+
Sbjct: 1100 KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERN--------WELKQRAAQVTHLDM 1151
Query: 94 SLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKD---LQRC 150
++ + E+ + + E T S + ++E ++ + L +++ ++Q++ K+ LQ
Sbjct: 1152 TIREHRGEMEQKIIKLEGTLEKSELELKECNKQI-ESLNDKLQNAKEQLREKEFIMLQNE 1210
Query: 151 ELLARLRQLEDEKKQMTLTRVE-LLTFQERYYKMK-EERDSYNDELVKVKDDNYNLAMRY 208
+ +++L++ E E+ Q + +E ++ QE+Y + +E EL ++ N +
Sbjct: 1211 QEISQLKK-EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQN---SH 1266
Query: 209 AQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE 268
+L+E ++ V R EI++L L M++ K + L ++ +E LE
Sbjct: 1267 TELAEARHQQVQAQR----EIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
Query: 269 LERENEMLKTKNQELQSIIQAGKRSL-------------PDSDKAILDILEHDRKEALED 315
+ E +K + E++S+ +A + DS K+ + L ++A +
Sbjct: 1323 ARMQAE-IKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE 1381
Query: 316 RQELVNRIYNLQEEARQAEEL 336
+E + + NL ++ + E+
Sbjct: 1382 LEEAQDTVSNLHQQVQDRNEV 1402
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 69.3 bits (168), Expect = 2e-11
Identities = 94/427 (22%), Positives = 188/427 (44%), Gaps = 68/427 (15%)
Query: 137 KLQQQMKA-KDLQR-CELLARLRQLE--------DEKKQMTLTRVELLTFQERYYKMKEE 186
K QQQ+ A K LQR C +LR + Q+T EL E K+KE+
Sbjct: 808 KKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEK 867
Query: 187 RDSYNDELVKVKDDNYNLAMRYAQLSEEKNM---AVMRSRDLQLEIDQLKHRLNKMEEEC 243
+ KV+ + + ++ QL EEKN+ + +L E ++++ RL ++E
Sbjct: 868 Q-------TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920
Query: 244 KLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILD 303
+ ++ +D+E+R ++E E N++L+ + +++Q+ IQ + L + + A
Sbjct: 921 E-------EILHDLESRVEEE-----EERNQILQNEKKKMQAHIQDLEEQLDEEEGA--- 965
Query: 304 ILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEK---EDLELKCST------- 353
R++ ++ +I ++EE E+ K+++EK ED +CS+
Sbjct: 966 -----RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 354 LGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEK 413
K+ +++ ++ LEE ++ ++ ++A+ + E + QI EL+ +
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG---ETTDLQDQIAELQAQ 1077
Query: 414 NDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLP--RNLPVTI--ISQDFGDASPRT 469
DE+++++ ++E L+ L R ++ + + +L R L I + +DF
Sbjct: 1078 IDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 470 NGQEADDSSTSEE---SPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKG 526
N E SEE + + L Q+ + K R + LK+ + + K
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK-----REQEVAELKKALEEETKN 1189
Query: 527 HEEEGTD 533
HE + D
Sbjct: 1190 HEAQIQD 1196
Score = 64.3 bits (155), Expect = 6e-10
Identities = 63/292 (21%), Positives = 134/292 (45%), Gaps = 21/292 (7%)
Query: 144 AKDLQRCELLARLRQLEDEKKQMTLTRV--ELLTFQERYYKMKEERDSYNDELVKVKDDN 201
A++ R E AR E E K ++L R E L +E + + ++ + ++L+ KDD
Sbjct: 1468 AEERDRAEAEAR----EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD- 1522
Query: 202 YNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEE-ECKLERN-QSLKLK----- 254
+ +L + K + +++ ++++L+ L E+ + +LE N Q++K +
Sbjct: 1523 --VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 255 --NDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDK---AILDILEHDR 309
D +N KK +++ RE E ++ +++ A K+ + K A ++ R
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 310 KEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVM 369
E ++ ++L ++ + Q E +A RD+ + ++ E K +L + + + +
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 370 LQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEM 421
E+ERD+ + + S L EK + +I +LEE+ +E + M
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/385 (24%), Positives = 159/385 (41%), Gaps = 78/385 (20%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLAR------LRQLEDEKKQMTLTRVELLTFQERYYKMK 184
++ ++ KLQ QMK D QR AR Q ++ +K++ E+L QE +
Sbjct: 1643 VIKQLRKLQAQMK--DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 185 -------EERDSYNDELVK-------VKDDNYNLAMRYAQLSEE-----KNMAVM--RSR 223
+ERD DE+ + D+ L R AQL EE NM ++ R R
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 224 DLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQEL 283
L++D L E ER+ + K N + +LER+N+ LK K QEL
Sbjct: 1761 KTTLQVDTLN-------AELAAERSAAQKSDNARQ---------QLERQNKELKAKLQEL 1804
Query: 284 QSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEE 343
+ +++ ++ + +A + LE ++ ++R N++ R+ E+ + +
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKER-AAANKL------VRRTEKKLKEIFMQ 1857
Query: 344 KEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKY 403
ED + E RM + QLEE E E +A SR
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR----------------- 1900
Query: 404 RKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFG 463
RK REL++ + E + RE + L+++LRR S + +S R L + S +
Sbjct: 1901 RKLQRELDDATEAN--EGLSRE--VSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956
Query: 464 DASPRTNGQEADDSSTSEESPEDSK 488
D + E+ S +E P S+
Sbjct: 1957 D-----DDTESKTSDVNETQPPQSE 1976
Score = 57.4 bits (137), Expect = 8e-08
Identities = 107/474 (22%), Positives = 195/474 (41%), Gaps = 94/474 (19%)
Query: 47 RQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLV 106
+Q KV E +E E + +L K +IL + Q +F E+ E K
Sbjct: 867 KQTKVEGELEEMERKHQQLLEEK--------NILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 107 TGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQM 166
+E + V EE E L NE K+Q ++ DL+ QL++E+
Sbjct: 919 ELEEILHDLESRVEEE--EERNQILQNEKKKMQAHIQ--DLEE--------QLDEEEGAR 966
Query: 167 TLTRVELLTFQERYYKMKEE---RDSYNDELVKVKD-DNYNLAMRYAQLSEE----KNMA 218
++E +T + + KM+EE + N + +K K +A +QL+EE KN+A
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 219 VMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKT 278
+R++ ++ I L+ RL K EE + + K K D E ++Q+ EL+ + + LK
Sbjct: 1027 KIRNKQ-EVMISDLEERLKK--EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 279 ----KNQELQSIIQAGK-------------RSLP----------DSDKAILDILEHDRKE 311
K +ELQ + G R L +S+KA + E +++
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 312 ALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLE--LKCSTLGKDCEMYKHR----- 364
E+ + L + + + +ELR K +E +L+ L+ T + ++ R
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203
Query: 365 -MNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE--------------KDKYRKQIRE 409
+ + QLE+ +R + ++ +T + E + K Q++E
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 410 LEEK---NDEMRIEMVRREACIVN-----------LESKLRRLSKDSNNLDQSL 449
L K D +R+E+ + + + N E K + +KD+ +L+ L
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Score = 56.2 bits (134), Expect = 2e-07
Identities = 62/322 (19%), Positives = 141/322 (43%), Gaps = 28/322 (8%)
Query: 136 IKLQQQMKAK-DLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDEL 194
+K+ QQ+KA+ + +R +L A++++L + + RVEL E+ K++ E D+ + L
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA---EKASKLQNELDNVSTLL 1296
Query: 195 VKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLK 254
+ + A A L + ++ + L R+ ++EEE K
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE-----------K 1345
Query: 255 NDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALE 314
N ++ + ++E+ E ++L ++Q A + D D ++ LE +K+ L+
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQ------LADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 315 DRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCS---TLGKDCEMYKHRMNTVMLQ 371
D + L R+ + E+ +++ +E +DL + + + E + + + ++ +
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 372 LEEVE----RERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREAC 427
+ + ERD+A E +T+ ++ + E E +N ++R +M +
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 428 IVNLESKLRRLSKDSNNLDQSL 449
++ + L K L+Q +
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQV 1541
Score = 56.2 bits (134), Expect = 2e-07
Identities = 62/318 (19%), Positives = 142/318 (44%), Gaps = 26/318 (8%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L+ + L Q+++ K L +L +L+ E +T+ L Q + E++
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD----LDHQRQVASNLEKKQKK 1452
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQS 250
D+L+ + +++ RYA EE++ A +R+ + + L L + E + Q+
Sbjct: 1453 FDQLLA---EEKSISARYA---EERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 251 LKLKNDIENRPKKEQ-----VLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDIL 305
+L+ D+E+ + V ELE+ L+ + +E+++ ++ + L ++
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE------- 1559
Query: 306 EHDRKEALEDRQELVNRIY--NLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKH 363
D K LE + + + +LQ Q EE + +++ +LE + K +
Sbjct: 1560 --DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 364 RMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVR 423
+ + L+++E + + A +RDE Q + + Y++++ E DE+ +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 424 REACIVNLESKLRRLSKD 441
E + +LE+++ +L ++
Sbjct: 1678 SEKKLKSLEAEILQLQEE 1695
Score = 52.4 bits (124), Expect = 2e-06
Identities = 73/339 (21%), Positives = 142/339 (41%), Gaps = 37/339 (10%)
Query: 134 EVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVEL----LTFQERYYKMKEERDS 189
+V +L ++ D R EL + +L++E ++ E + F + ++ +
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 190 YNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
+ L + NL+ R QL EEKN LQ + ++ + +E++ ++Q
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKN-------SLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 250 SLKLKNDIEN---------RPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA 300
K +++ KK+ + + E ++ L+ K + + R + D
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 301 ILDILEHDRKEA--LEDRQELVNRIYNLQEE----ARQAEELRDKYLEEKEDLELKCSTL 354
+D L+H R+ A LE +Q+ +++ L EE AR AEE RD+ E + E K +L
Sbjct: 1433 TVD-LDHQRQVASNLEKKQKKFDQL--LAEEKSISARYAEE-RDRAEAEAREKETKALSL 1488
Query: 355 GKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKN 414
+ E Q +++ + + S+D+ + +EK K R LE++
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSK-----RALEQQV 1541
Query: 415 DEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNL 453
+EMR ++ E + E RL + + R+L
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 68.6 bits (166), Expect = 3e-11
Identities = 84/409 (20%), Positives = 173/409 (42%), Gaps = 63/409 (15%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L E L+ Q+K + Q L A++ L+ +Q + + T Q + K++ E +
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQ---RQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEID---------QLKHRLNKMEE 241
N + + + N L ++ + L E + DL+ D +L H E
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174
Query: 242 ECKLERNQSLKLKN--------DIENRPKK-----------EQVLELERENEMLKTKNQE 282
E + ++ +LK + D+E+R + E++L++E+E +L+ KN E
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234
Query: 283 LQSIIQAGKRSLPDSDKAILDILEHDRKEALE-------DRQELVNRIYNLQEEARQAEE 335
++ K+ ++D+ L H + L+ D + L + + N + E + E
Sbjct: 1235 --TVAAEYKKLCGENDR-----LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1287
Query: 336 LRDKYLEEKEDLELKCSTLGKDCEMY-----------KHRMNTVMLQLEEVERERDQAFH 384
K E+ + L++ + L CE+ +H ++ + + + +Q
Sbjct: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNME 1347
Query: 385 SRDEAQTQYSQCLIEKDKYRKQIRELEEK-NDEMRI---EMVRREACIVNLESKLRRLSK 440
S+D + Q + + ++ R+Q +LEEK D+ + RR + L K+R+L K
Sbjct: 1348 SKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITL--KMRKLIK 1405
Query: 441 DSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSST-SEESPEDSK 488
++++ ++L +T D + + Q++ DSS+ S ED +
Sbjct: 1406 SKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1454
Score = 62.8 bits (151), Expect = 2e-09
Identities = 77/358 (21%), Positives = 168/358 (46%), Gaps = 45/358 (12%)
Query: 113 RRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQR---------CELLARLRQLEDEK 163
R+ + E H T + + ++ + + KD+++ E ++L ++E EK
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYN-----DELVKVKDDNYNLAMRYAQLSEEKNMA 218
+Q+ + EL ++E+ + +E + + +EL++ K N + + E++N
Sbjct: 611 RQI---KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 219 VMR-SRDLQLEIDQLKH---RLNKMEEECKLERNQSLKLKNDIEN-RPKKEQVLELEREN 273
+ R +R L+ +D K+ +L +E+E ++L+L+ ++E+ + ++ +L+ EN
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 274 EMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQA 333
+ L+++ ++L+ ++ K S +++ LE + + Q L + N ++ +Q
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTER-----LEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 334 EELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQY 393
E E +DLE++ TL K+ E K +LE++E+E S ++ +Q
Sbjct: 783 ES-------ELQDLEMENQTLQKNLEELKISSK----RLEQLEKENK----SLEQETSQL 827
Query: 394 SQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+ + +K K++R+ E D E I NLE + + LSK+ +S R
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEE---NNVKIGNLEKENKTLSKEIGIYKESCVR 882
Score = 61.2 bits (147), Expect = 5e-09
Identities = 84/388 (21%), Positives = 168/388 (43%), Gaps = 59/388 (15%)
Query: 118 IVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLR-QLEDEKKQMTLTRVELLTF 176
I + E +GL HFL + Q + ++R E L +L D K ++ R EL
Sbjct: 212 IELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK 270
Query: 177 QERYYKMKEERDSYNDELVKVKDDNYNL------AMRYAQLSEEKNMAVMRSRDLQLEID 230
E+ K+E + EL +++ +N NL A Y + +R L+ E+
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 231 QLKHRLNKME------EECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTK 279
+ K RL+ +E EE K + L+ K +E+ R + +++ ELE+EN LK K
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 280 NQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED------RQELVNRIYNLQEEARQA 333
+++ ++ + + + + LE +K+++++ E ++R L E +++
Sbjct: 391 LHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 334 --EELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTV------MLQLEE----------- 374
E+ + LE++ +L K E + +++V +L++E+
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 375 VERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVR----------- 423
+E E Q S Q + EK + K I L E N E +I+++
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQENEHLNQTVS 568
Query: 424 --REACIVNLESKLRRLSKDSNNLDQSL 449
R+ ++ E++++ + K++ L +S+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESI 596
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 64/358 (17%)
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
L++ ++ K+ + L ARL + + +Q+ R EL T ++ Y E +K
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQL---RQELKTVKKNY------------EALKQ 1009
Query: 198 KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDI 257
+ D + +S E N S++ E+ ++K RL ++E + + LK +
Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Query: 258 -----ENRPKKEQVLELER-------ENEMLKTKNQELQ---SIIQAGKRSLPDSDKAIL 302
+N + Q+L L+R +N L+T+N +LQ S + + SL + + +L
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
Query: 303 ---DILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTL----- 354
LE++ + +++R++L + +L ++ + E L ++ E E L K TL
Sbjct: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Query: 355 -----GKDCEMYKHRMNTVMLQLEEVER---------------------ERDQAFHSRDE 388
+D E +++ QLE++E+ E + D
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 389 AQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD 446
YSQ L E + + + L+ + ++E R EA L+ + ++L S L+
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307
Score = 55.8 bits (133), Expect = 2e-07
Identities = 68/310 (21%), Positives = 139/310 (44%), Gaps = 45/310 (14%)
Query: 154 ARLRQLEDEKKQM------TLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMR 207
AR++ +E E K + T +++ + F++R ++K+E + Y ++ R
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKR--QIKKELEHYKEK-----------GER 626
Query: 208 YAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME----EECKLERNQSLKLKNDIENRPKK 263
+L E + + LQ +I LK K+E E +LER ++ KLK +++
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER-ENRKLKKTLDSFKNL 685
Query: 264 EQVLE-LERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNR 322
LE LE+EN L +N EL+ +++ K + + L+ + KE ++++L
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-----LQLENKELESEKEQLKKG 740
Query: 323 IYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQA 382
+ L+ ++ E L Y + L+++ L K E ++ + +L+++E E
Sbjct: 741 LELLKASFKKTERLEVSY----QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 383 FHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDS 442
+ +E + K++ +LE++N + E + E LE + +RL + +
Sbjct: 797 QKNLEELKIS-----------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 443 NNLDQSLPRN 452
D +L N
Sbjct: 846 EIKDTTLEEN 855
Score = 53.1 bits (126), Expect = 1e-06
Identities = 62/308 (20%), Positives = 137/308 (44%), Gaps = 39/308 (12%)
Query: 137 KLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVK 196
+LQ+ ++ + + +L + L+ LE E + + EL +R ++++E S E +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
Query: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKND 256
++ D L +L ++ + + ++I L+ + +E + + ++LK
Sbjct: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK-- 884
Query: 257 IENRPKKEQVLELEREN-EMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED 315
ELE+EN E++K ++++++ + + S+K + +D ++ +
Sbjct: 885 -----------ELEKENKELVKRATIDIKTLVTLREDLV--SEKLKTQQMNNDLEKLTHE 931
Query: 316 RQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEV 375
+++ L + + ++ R K LE K + STL K E+
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLE-----STLKKSL---------------EI 971
Query: 376 ERERDQAFHSRDEAQTQYSQCLIEKDK-YRKQIRELEEKNDEMRIEMVRREACIVNLESK 434
+ E+ A +R E T Y+Q L ++ K +K L+++ DE R MV+ I ++K
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER--MVQSSPPISGEDNK 1029
Query: 435 LRRLSKDS 442
R S+++
Sbjct: 1030 WERESQET 1037
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 68.6 bits (166), Expect = 3e-11
Identities = 84/409 (20%), Positives = 173/409 (42%), Gaps = 63/409 (15%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L E L+ Q+K + Q L A++ L+ +Q + + T Q + K++ E +
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQ---RQTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEID---------QLKHRLNKMEE 241
N + + + N L ++ + L E + DL+ D +L H E
Sbjct: 1114 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1173
Query: 242 ECKLERNQSLKLKN--------DIENRPKK-----------EQVLELERENEMLKTKNQE 282
E + ++ +LK + D+E+R + E++L++E+E +L+ KN E
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1233
Query: 283 LQSIIQAGKRSLPDSDKAILDILEHDRKEALE-------DRQELVNRIYNLQEEARQAEE 335
++ K+ ++D+ L H + L+ D + L + + N + E + E
Sbjct: 1234 --TVAAEYKKLCGENDR-----LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 336 LRDKYLEEKEDLELKCSTLGKDCEMY-----------KHRMNTVMLQLEEVERERDQAFH 384
K E+ + L++ + L CE+ +H ++ + + + +Q
Sbjct: 1287 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNME 1346
Query: 385 SRDEAQTQYSQCLIEKDKYRKQIRELEEK-NDEMRI---EMVRREACIVNLESKLRRLSK 440
S+D + Q + + ++ R+Q +LEEK D+ + RR + L K+R+L K
Sbjct: 1347 SKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITL--KMRKLIK 1404
Query: 441 DSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSST-SEESPEDSK 488
++++ ++L +T D + + Q++ DSS+ S ED +
Sbjct: 1405 SKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1453
Score = 62.8 bits (151), Expect = 2e-09
Identities = 77/358 (21%), Positives = 168/358 (46%), Gaps = 45/358 (12%)
Query: 113 RRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQR---------CELLARLRQLEDEK 163
R+ + E H T + + ++ + + KD+++ E ++L ++E EK
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYN-----DELVKVKDDNYNLAMRYAQLSEEKNMA 218
+Q+ + EL ++E+ + +E + + +EL++ K N + + E++N
Sbjct: 611 RQI---KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 219 VMR-SRDLQLEIDQLKH---RLNKMEEECKLERNQSLKLKNDIEN-RPKKEQVLELEREN 273
+ R +R L+ +D K+ +L +E+E ++L+L+ ++E+ + ++ +L+ EN
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 274 EMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQA 333
+ L+++ ++L+ ++ K S +++ LE + + Q L + N ++ +Q
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTER-----LEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 334 EELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQY 393
E E +DLE++ TL K+ E K +LE++E+E S ++ +Q
Sbjct: 783 ES-------ELQDLEMENQTLQKNLEELKISSK----RLEQLEKENK----SLEQETSQL 827
Query: 394 SQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+ + +K K++R+ E D E I NLE + + LSK+ +S R
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEE---NNVKIGNLEKENKTLSKEIGIYKESCVR 882
Score = 61.2 bits (147), Expect = 5e-09
Identities = 84/388 (21%), Positives = 168/388 (43%), Gaps = 59/388 (15%)
Query: 118 IVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLR-QLEDEKKQMTLTRVELLTF 176
I + E +GL HFL + Q + ++R E L +L D K ++ R EL
Sbjct: 212 IELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK 270
Query: 177 QERYYKMKEERDSYNDELVKVKDDNYNL------AMRYAQLSEEKNMAVMRSRDLQLEID 230
E+ K+E + EL +++ +N NL A Y + +R L+ E+
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 231 QLKHRLNKME------EECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTK 279
+ K RL+ +E EE K + L+ K +E+ R + +++ ELE+EN LK K
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 280 NQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED------RQELVNRIYNLQEEARQA 333
+++ ++ + + + + LE +K+++++ E ++R L E +++
Sbjct: 391 LHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 334 --EELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTV------MLQLEE----------- 374
E+ + LE++ +L K E + +++V +L++E+
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 375 VERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVR----------- 423
+E E Q S Q + EK + K I L E N E +I+++
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQENEHLNQTVS 568
Query: 424 --REACIVNLESKLRRLSKDSNNLDQSL 449
R+ ++ E++++ + K++ L +S+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESI 596
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 64/358 (17%)
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
L++ ++ K+ + L ARL + + +Q+ R EL T ++ Y E +K
Sbjct: 964 LKKSLEIKEEKIAALEARLEESTNYNQQL---RQELKTVKKNY------------EALKQ 1008
Query: 198 KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDI 257
+ D + +S E N S++ E+ ++K RL ++E + + LK +
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1068
Query: 258 -----ENRPKKEQVLELER-------ENEMLKTKNQELQ---SIIQAGKRSLPDSDKAIL 302
+N + Q+L L+R +N L+T+N +LQ S + + SL + + +L
Sbjct: 1069 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1128
Query: 303 ---DILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTL----- 354
LE++ + +++R++L + +L ++ + E L ++ E E L K TL
Sbjct: 1129 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1188
Query: 355 -----GKDCEMYKHRMNTVMLQLEEVER---------------------ERDQAFHSRDE 388
+D E +++ QLE++E+ E + D
Sbjct: 1189 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248
Query: 389 AQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD 446
YSQ L E + + + L+ + ++E R EA L+ + ++L S L+
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
Score = 55.8 bits (133), Expect = 2e-07
Identities = 68/310 (21%), Positives = 139/310 (44%), Gaps = 45/310 (14%)
Query: 154 ARLRQLEDEKKQM------TLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMR 207
AR++ +E E K + T +++ + F++R ++K+E + Y ++ R
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKR--QIKKELEHYKEK-----------GER 626
Query: 208 YAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME----EECKLERNQSLKLKNDIENRPKK 263
+L E + + LQ +I LK K+E E +LER ++ KLK +++
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER-ENRKLKKTLDSFKNL 685
Query: 264 EQVLE-LERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNR 322
LE LE+EN L +N EL+ +++ K + + L+ + KE ++++L
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-----LQLENKELESEKEQLKKG 740
Query: 323 IYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQA 382
+ L+ ++ E L Y + L+++ L K E ++ + +L+++E E
Sbjct: 741 LELLKASFKKTERLEVSY----QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 383 FHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDS 442
+ +E + K++ +LE++N + E + E LE + +RL + +
Sbjct: 797 QKNLEELKIS-----------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 443 NNLDQSLPRN 452
D +L N
Sbjct: 846 EIKDTTLEEN 855
Score = 51.2 bits (121), Expect = 6e-06
Identities = 65/309 (21%), Positives = 141/309 (45%), Gaps = 42/309 (13%)
Query: 137 KLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVK 196
+LQ+ ++ + + +L + L+ LE E + + EL +R ++++E S E +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
Query: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKND 256
++ D L +L ++ + + ++I L+ + +E + + ++LK
Sbjct: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK-- 884
Query: 257 IENRPKKEQVLELEREN-EMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED 315
ELE+EN E++K ++++++ + + S+K + +D ++ +
Sbjct: 885 -----------ELEKENKELVKRATIDIKTLVTLREDLV--SEKLKTQQMNNDLEKLTHE 931
Query: 316 RQEL-VNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEE 374
+++ +N+ L +E Q+ + R K LE K + STL K E
Sbjct: 932 LEKIGLNKERLLHDE--QSTDDRYKLLESKLE-----STLKKSL---------------E 969
Query: 375 VERERDQAFHSRDEAQTQYSQCLIEKDK-YRKQIRELEEKNDEMRIEMVRREACIVNLES 433
++ E+ A +R E T Y+Q L ++ K +K L+++ DE R MV+ I ++
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER--MVQSSPPISGEDN 1027
Query: 434 KLRRLSKDS 442
K R S+++
Sbjct: 1028 KWERESQET 1036
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.2 bits (165), Expect = 4e-11
Identities = 75/308 (24%), Positives = 138/308 (44%), Gaps = 37/308 (12%)
Query: 139 QQQMKAKDLQRCELLARLRQL-------------EDEKKQMTLTRVELLTFQER--YYKM 183
QQ + + L+R + L R +QL E E+++ L R + +ER + K
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ----EERRDWLKR 460
Query: 184 KEERDSYNDELVKV---KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ---LKHRLN 237
+EE + + E K +D R+ +L EE+ R+ QL +Q + RL
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 238 KMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDS 297
+ EEE +L++ + + E ++EQ+L+ E E + + + + Q KR +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE------QRLKREQEER 574
Query: 298 DKAILDILEHDRKEALEDRQE--LVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLG 355
+L E R++ L+ QE L R+ + E + EE R++ L+ +E E + L
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 356 KDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKND 415
K E + R QL ++ER + R+E + + Q L + + ++ +EL E+
Sbjct: 635 KSEEQEERRQQ----QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 416 EMRIEMVR 423
E E ++
Sbjct: 691 EQARERIK 698
Score = 64.3 bits (155), Expect = 6e-10
Identities = 67/296 (22%), Positives = 138/296 (46%), Gaps = 17/296 (5%)
Query: 139 QQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYN--DELVK 196
+QQ++ ++ Q+ R R+ ++++ + + L QER K EE + +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKND 256
++ D QL +E +R ++ + + + +L + E E K + + + +
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 257 IENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED- 315
+E + ++E+ L E E E L+ QE I ++ P+ ++ L E DRK E+
Sbjct: 1721 LERKFREEEQLRQETEQEQLR--RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 316 -RQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEE 374
RQE + QE R+ E ++ +E+E+ +L+ K+R LQLEE
Sbjct: 1779 LRQEREEQQLRSQESDRKFRE-EEQLRQEREEQQLRPQQRDG-----KYRWEEEQLQLEE 1832
Query: 375 VE----RERDQAFHSRDEAQTQYSQCLIEKDKYR-KQIRELEEKNDEMRIEMVRRE 425
E +ERD+ + + ++ TQ E++ ++ ++ + +E+ ++R E +RR+
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Score = 63.2 bits (152), Expect = 1e-09
Identities = 67/321 (20%), Positives = 143/321 (44%), Gaps = 35/321 (10%)
Query: 129 HFLMNEVIKLQQQMKAKDLQRCELLARLRQLE---DEKKQMTLTRVELLTFQERYYKMKE 185
H +E + +Q++K + +R + L R + E E+++ L R + +ER+ K++E
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 186 E-----RDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME 240
E ++ +L + +++ ++ + E + + L+ E ++ + +L K E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 241 EECKLERNQ-SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPD--- 296
EE +LE+ + +LK + E R ++Q+L+ E E + K ++ + + Q KR +
Sbjct: 554 EEKRLEQERREQRLKREQEER--RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 297 -----SDKAILDILEHDRKEAL----------------EDRQELVNRIYNLQEEARQAEE 335
+ + E +R++ L E ++ R+ +EE R +
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 336 LRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQ 395
L+ ++ EE+ + EL + E K R+ QLE R +SR Q +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 396 CLIEKDKYRKQIRELEEKNDE 416
+++K R++ EL+ + +E
Sbjct: 732 RQEQEEKRRRRESELQWQEEE 752
Score = 62.8 bits (151), Expect = 2e-09
Identities = 78/408 (19%), Positives = 167/408 (40%), Gaps = 41/408 (10%)
Query: 139 QQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVK 198
QQ+++ + R + R+ ++E+++ R + + R +++ E++ ++ ++ +
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQ--QEERREQQLRREQEERREQQLRRE 354
Query: 199 DDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDI- 257
+ + + EE+ R+ QL +Q R ++ E +L R Q L+ + +
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 258 -ENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDR 316
E + ++EQ L E+E E + K+++ + E K E+R
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQ--------------------ERREQRLKREQEER 454
Query: 317 QELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVE 376
++ + R +E R +E R + L+ ++ E + L + E + + QL +
Sbjct: 455 RDWLKR---EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 377 RERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEE----KNDEMRIEMVRREACIVNLE 432
ER + R E + + Q L + + R++ E E + +E R+E RRE + +
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 433 SKLR--RLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSK-- 488
+ R L ++ Q L R + + + R +E + E PE+ +
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 489 YFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQ------AKGHEEE 530
L + R + + Q+ + LKR + + + HEEE
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Score = 60.8 bits (146), Expect = 7e-09
Identities = 64/285 (22%), Positives = 132/285 (46%), Gaps = 40/285 (14%)
Query: 145 KDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNL 204
+ L+R ELL R+ +EK+Q R Q+R ++ +EE++ E V K++
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRER------QDRVFQEEEEKEWRKRETVLRKEEE--- 258
Query: 205 AMRYAQLSEEKNMAVMRSRDLQLEIDQL---------KHRLNKMEEECKLERNQSLKLKN 255
+L EE+ R R+LQ E +QL + R + +++ +L R Q L+ K
Sbjct: 259 -----KLQEEE---PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Query: 256 DIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALED 315
+ E R ++E+ E + E + + ++ Q +R + R+E E+
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERRE------------QQLRREQEEE 358
Query: 316 RQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEV 375
R+E ++ QEE R+ ++LR + +E + L ++ ++ + + QL
Sbjct: 359 RRE--QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 376 ERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420
++ R + R++ + ++ Q ++ + ++ RE EE+ D ++ E
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461
Score = 60.5 bits (145), Expect = 9e-09
Identities = 62/257 (24%), Positives = 115/257 (44%), Gaps = 22/257 (8%)
Query: 192 DELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSL 251
DE + + D ++ + E++ R R L+ E Q + R + E+E +L +
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQ-RRRQKRQEQERELAEGEEQ 154
Query: 252 KLKND-IENRPKKEQVLELER------ENEMLKTKNQELQSIIQAGKRSLPDSD----KA 300
K + +E R ++ + EL R E E + + ++LQS PD + +
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 301 ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM 360
+L++ R+E + R+E +R++ QEE + R+ L ++E+ +L+ + E+
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVF--QEEEEKEWRKRETVLRKEEE-KLQEEEPQRQREL 271
Query: 361 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420
+ L+ +E+ RE R E + Q + E+ RKQ E E+ +E R +
Sbjct: 272 QEEEEQLRKLERQELRRE-------RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 421 MVRREACIVNLESKLRR 437
RRE E +LRR
Sbjct: 325 QERREQQEERREQQLRR 341
Score = 59.7 bits (143), Expect = 2e-08
Identities = 85/382 (22%), Positives = 167/382 (43%), Gaps = 50/382 (13%)
Query: 129 HFLMNEVIKLQQQMKAK--DLQRCELLARLRQLEDEKKQMTLT--------------RVE 172
HF E ++ ++Q +AK D + E LR+ +EK++ T +
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Query: 173 LLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQL 232
L QER K +EE + ++ K ++ L + + K +R ++ + ++ Q
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 233 KHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTK---NQELQSIIQA 289
+ R + EEE +L R + D + R +++QV ERE + L+ + QE +
Sbjct: 1412 RDRKFR-EEEQQLSRQE-----RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 290 GKRSLPDSDKAILDILEHDRKEALEDRQEL--VNRIYNLQEEARQAEELRDKYLEEKEDL 347
++ L + ++ L E DRK LE+ Q+L R +E+ +++E K+LEE++ L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRK-FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 348 --------------ELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQY 393
+L+ G+ + R + E++ +ER++ SR E ++
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK---FREEEQLRQEREEQQLSRQERDRKF 1581
Query: 394 SQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNL 453
+E+ K R+Q +E + DE ++ R+E + + R+ +D L + + L
Sbjct: 1582 R---LEEQKVRRQEQERKFMEDEQQLR--RQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 454 PVTIISQDFGDASPRTNGQEAD 475
+ F + P+ QE +
Sbjct: 1637 HRQERDRKFLEEEPQLRRQERE 1658
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/308 (22%), Positives = 136/308 (44%), Gaps = 34/308 (11%)
Query: 139 QQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERD-SYNDELVKV 197
+QQ++ ++ +R + L +QL E+ + +LL +E ++ERD + +E ++
Sbjct: 1436 EQQVRRQERER-KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 198 KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ-SLKLKND 256
+ + R +L ++ + QL Q + + ++EE +L R + + + D
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF--LQEEQQLRRQERGQQRRQD 1552
Query: 257 IENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDR 316
+ + ++E+ L ERE + L + ++ + ++ K + ++ + ED
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM-----------EDE 1601
Query: 317 QELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEV- 375
Q+L QE +Q + RD+ E E L L + E HR LEE
Sbjct: 1602 QQL-----RRQEGQQQLRQERDRKFREDEQL------LQEREEQQLHRQERDRKFLEEEP 1650
Query: 376 ---ERERDQAF-HSRDEAQTQYSQCLIE--KDKYRKQIRELEEKNDEMRIEMVRREACIV 429
+ER+Q H RD + Q L E + + R+Q R+ + + +E ++ RE +
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 430 NLESKLRR 437
E +LRR
Sbjct: 1711 QEEQQLRR 1718
Score = 57.0 bits (136), Expect = 1e-07
Identities = 57/287 (19%), Positives = 132/287 (45%), Gaps = 28/287 (9%)
Query: 134 EVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDE 193
E + +++ K + +R + ++L+ +++Q+ E QER K +EE + +E
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME----EECKLERNQ 249
++++ + + K + + + L ++ K RL + E EE +L++ +
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
L + E R ++E + +E E+ + + Q L+ + KR + ++ +
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE--EPEKRRRQERERQC-----REE 1113
Query: 310 KEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVM 369
+E ++ ++L+ + E R+ +EL +Y EE+E + + L ++ E +
Sbjct: 1114 EELQQEEEQLLRE----EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR------ 1163
Query: 370 LQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE 416
+E+ER+ + +E Q + Q L E+ + R+Q RE + + +E
Sbjct: 1164 ---QELERQ----YREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Score = 55.8 bits (133), Expect = 2e-07
Identities = 72/353 (20%), Positives = 155/353 (43%), Gaps = 48/353 (13%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L E + + + AK + +L + L++E++++ E QE+ + +EE
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQL----------KHRLNKME 240
+E ++++ R + +E+ + + LQ + +QL + R K
Sbjct: 938 QEEEQLLREE------REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 241 EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA 300
EE +L++ + L+ + E R ++E + +++E+ + + Q L+ + KR L + ++
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE--EREKRRLQERERQ 1049
Query: 301 IL--DILEHDRKEALED-----RQELVNRIYNLQEEARQAEEL-------------RDKY 340
+ L+ + ++ L + R++ + R Y +EE +Q EE R++
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 341 LEEKEDLELKCSTLGKDCEMYKHRMNTVMLQL---EEVERERDQAFHS------RDEAQT 391
E+E+L+ + L ++ E K R + Q EEV++E +Q R E +
Sbjct: 1110 CREEEELQQEEEQLLRE-EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 392 QYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNN 444
QY + + + + +RE +EK + R R E + + K R +D +
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Score = 54.3 bits (129), Expect = 7e-07
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 17/274 (6%)
Query: 158 QLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNM 217
QLE+E+K+ T QE+ K ++ +EL + + + + Q EE+ +
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Query: 218 AVMRSRDLQLEIDQLKH--RLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEM 275
+ L+ E ++ + R + ++ KL++ + L + E R ++E+ + E E+
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 276 LKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEE 335
+ + Q L+ + +R + D L+ + ++ L + +E LQE RQ
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK----RRLQERERQ--- 1049
Query: 336 LRDKYLEEKEDLELKCSTLGKDCEMYKHR-MNTVMLQLEEVERERDQAFHSRDE---AQT 391
Y EE+E + + LG++ E + + + + EE+++E +Q E Q
Sbjct: 1050 ----YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Query: 392 QYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRRE 425
+ QC E++ +++ + L E+ ++ R + + R+
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139
Score = 50.8 bits (120), Expect = 7e-06
Identities = 86/420 (20%), Positives = 178/420 (42%), Gaps = 38/420 (9%)
Query: 134 EVIKLQQQ-MKAKDLQRCELLARLRQLEDEK---KQMTLTRVELLTFQERYYKMKEERDS 189
E+++L+++ + K QR E R+ Q E+EK K+ T+ R E QE + + E
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 190 YNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEID-----QLKHRLNKMEEECK 244
++L K++ R Q E++ + R + L+ + + Q + R + E +
Sbjct: 274 EEEQLRKLERQELR---RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 245 LERNQSLKLKNDIENRPKKEQVLELERENE----MLKTKNQELQSIIQAGKRSLPDSDKA 300
E + +L+ + E R +EQ L E+E E L+ + +E + Q + ++
Sbjct: 331 QEERREQQLRREQEER--REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388
Query: 301 ILDILEHDRKEALEDRQEL-----VNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLG 355
+ + R++ L Q+L + R L+ E + E ++ E+K + E + L
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 356 KDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCL-IEKDKYRKQ----IREL 410
++ E + + + E E+ER + RD+ + + + L +E+++ R+Q ++L
Sbjct: 449 REQEERRDWLKREE-ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 411 EEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTN 470
+ +E R + ++R+ L+ +LR S+ +Q R Q +
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLR--SEQQLRREQEERR-------EQLLKREEEKRL 558
Query: 471 GQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEE 530
QE + E E L +R+ LK Q +R + + + + + E+
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Score = 50.1 bits (118), Expect = 1e-05
Identities = 68/342 (19%), Positives = 151/342 (44%), Gaps = 46/342 (13%)
Query: 138 LQQQMKAKDLQRCELLARLR-QLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVK 196
L+++ + + Q E R + +L+ E++Q+ E QER + +EE + +E
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQL------KHRLNKMEEECK----LE 246
+ ++ R + +E + +LQ E +QL K R + E +C+ L+
Sbjct: 1064 LGEE------RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 247 RNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILE 306
+ + L+ + E R ++E + E E+ + + Q L+ + +R + + L+
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177
Query: 307 HDRKEALEDRQELVNRIYNLQ---EEARQAEELRDKYLEEKEDLELKC------STLGKD 357
+ ++ L + QE + Q EE Q ++ + +Y +E + +LK +D
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 358 CEMY-KHRMNTVMLQLEEVE-RER-----------DQAFHSRDEAQTQYSQCLIEKDKY- 403
++Y K R N QLE+ + R+R +Q R++ + ++ Q +D++
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ----RDRHF 1293
Query: 404 --RKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSN 443
+Q+ E+K + R + E ++ E + +R ++++
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Score = 47.8 bits (112), Expect = 6e-05
Identities = 75/347 (21%), Positives = 141/347 (40%), Gaps = 38/347 (10%)
Query: 110 EPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARL-RQLEDEKKQMTL 168
E RR + EE E L E + ++Q ++ + L RL R+ E+E+++ L
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685
Query: 169 TRVELLTFQERY--------YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVM 220
E +ER ++++ E D+ ++ R Q EEK
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS--RPRKQEGQRRRQEQEEKRRR-- 741
Query: 221 RSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKN 280
R +LQ + ++ HR + EEE + + + + E ++ RE + +
Sbjct: 742 RESELQWQEEERAHR-QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 281 QELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKY 340
+E Q Q +R LP+ E ++++ R+E + L+EE + R +
Sbjct: 801 EERQ---QREQRFLPE---------EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 341 LEEKEDLELKCSTLGKDCE----MYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQY--S 394
L+E+ED L +D E + R QLEE + R +++ Q Q
Sbjct: 849 LQEEED------GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 395 QCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKD 441
Q L+++++ Q E E++ + + R E + E +L R ++
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 68.2 bits (165), Expect = 4e-11
Identities = 71/363 (19%), Positives = 150/363 (41%), Gaps = 49/363 (13%)
Query: 133 NEVIKLQQQMKAKDLQRCELLARLRQLEDEKK-----------QMTLTRVELLTF----Q 177
NE ++Q ++A ++ EL +LR E KK +M + ++ F Q
Sbjct: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 178 ERYYKMKEERDSYNDEL------------------VKVKDDNYNLAMRYAQLSEEKNMAV 219
++ +++EE D E+ +K++ + M Y LS++ +
Sbjct: 1687 QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM 1746
Query: 220 MRSRDLQLEIDQLKHRL-NKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKT 278
L E+ LKH++ + ++ LE + + ++ + E E ++ + +
Sbjct: 1747 SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806
Query: 279 KNQELQSIIQAGKRSLPDSDKAILDILEHDR-KEALEDRQELVNRIYNLQEEARQAEELR 337
+ + K + P K D HD L+ +L RI L+EE ++ +E
Sbjct: 1807 TRPTCSESVPSAKSANPAVSK---DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFS 1863
Query: 338 DKYLEEKEDLELKCSTLGKDCEMYKH---RMNTVMLQLEE----VERERDQAFHSRDEAQ 390
EK L + ST + +M + +MN + Q++E V + ++ A +D+ +
Sbjct: 1864 QTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE 1923
Query: 391 TQYSQCLIEKD----KYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD 446
+ L E + Y + + + + KN+ + EM + C+ LE + ++L K+ ++
Sbjct: 1924 ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE 1983
Query: 447 QSL 449
+
Sbjct: 1984 SEI 1986
Score = 54.7 bits (130), Expect = 5e-07
Identities = 80/371 (21%), Positives = 166/371 (44%), Gaps = 60/371 (16%)
Query: 93 ESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCEL 152
E + ++ L++GKE + + + + H+ E+ +L+ + ++ + L
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHD-------KEIKELENLLSQEEEENIVL 2427
Query: 153 LARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLS 212
++ D+ Q+ T L T ++ + K + DS+ + +++D + Y QL
Sbjct: 2428 EEENKKAVDKTNQLMET---LKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL- 2483
Query: 213 EEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERE 272
EE++++++ LE DQL +E E N KLK +I R + + +L E
Sbjct: 2484 EERHLSII------LEKDQLI-------QEAAAENN---KLKEEI--RGLRSHMDDLNSE 2525
Query: 273 NEMLKTK----NQELQSIIQAGKRSLPDSD-KAILDILEHDRKEALEDRQELVNRIYNLQ 327
N L + ++L +I ++ DS K +L++ L+ +EL N+ L+
Sbjct: 2526 NAKLDAELIQYREDLNQVI-----TIKDSQQKQLLEV-------QLQQNKELENKYAKLE 2573
Query: 328 EEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQA-FHSR 386
E+ +++EE + L+ + L K+ E K ++ + Q+ ++ E +H++
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
Query: 387 ---DEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREAC--IVNLESKLRRLSKD 441
E + L +K+I ELEE+ + V++EA + +E KL++ K
Sbjct: 2634 LKVKEEEVHRLSALFSSS--QKRIAELEEE-----LVCVQKEAAKKVGEIEDKLKKELKH 2686
Query: 442 SNNLDQSLPRN 452
++ D + RN
Sbjct: 2687 LHH-DAGIMRN 2696
Score = 54.3 bits (129), Expect = 7e-07
Identities = 71/329 (21%), Positives = 150/329 (45%), Gaps = 63/329 (19%)
Query: 92 LESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCE 151
L+ ++ + E L+ + + V EG E + H + ++V +L Q + K+L+
Sbjct: 819 LDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRH-ISSKVEELSQALSQKELE--- 874
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
+ ++ QL EKK+ ++ T Q+ EE+D +V + ++++ + QL
Sbjct: 875 -ITKMDQLLLEKKR------DVETLQQTI----EEKDQ------QVTEISFSMTEKMVQL 917
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVL--EL 269
+EEK + + L+ +++ L +E+ + + S LK + + Q+ EL
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 270 ERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEE 329
+ E ++LK +N++ + +QA AL +R+EL+ R+ L+EE
Sbjct: 978 QHEFDLLKKENEQRKRKLQA----------------------ALINRKELLQRVSRLEEE 1015
Query: 330 ARQ-----------AEELRDKYLEEKEDLEL--KCSTLG-KDCEMY-KHRMNTVMLQLEE 374
+E R + E+KE+ E KC T ++ E+Y K ++ ++L+
Sbjct: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075
Query: 375 VERERDQAFHSRDEAQT---QYSQCLIEK 400
+ ++ ++ + ++ Q Q +Q L +K
Sbjct: 1076 IRKDLEEKLAAEEQFQALVKQMNQTLQDK 1104
Score = 53.9 bits (128), Expect = 9e-07
Identities = 87/388 (22%), Positives = 172/388 (44%), Gaps = 46/388 (11%)
Query: 134 EVIKLQQQMKAKDLQRCEL----LARLRQLEDEKKQMTL---TRVELLTFQERYYKMKEE 186
+V LQQ ++ KD Q E+ ++ QL +EK + + T E L R + K+E
Sbjct: 888 DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKE 947
Query: 187 RDSYNDELVKVKDDNYNLAMRYAQLSEE---------KNMAVMRSRDLQLEI---DQLKH 234
+ ++E+ NY+ Q+S+E K R R LQ + +L
Sbjct: 948 QVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQ 1007
Query: 235 RLNKMEEECKLERNQSLKL--KNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKR 292
R++++EEE +++S K ++ E +E E + + +K QE++ + K+
Sbjct: 1008 RVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL---KQ 1064
Query: 293 SLPDSDKAILDILEHDRKE------ALEDRQELVNRI-YNLQEEARQAEELRDKYLEEKE 345
++ + + L+H RK+ A E Q LV ++ LQ++ Q + L+ + E +
Sbjct: 1065 TISEKEVE----LQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQA 1120
Query: 346 DLE--LKCSTLGKDCEMYKHRMNTVMLQ------LEEVERERDQAFHSRDEAQTQYSQCL 397
++ + +T D + TV++ E + E ++ + ++ + Q + L
Sbjct: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Query: 398 IEKDKYRKQI-RELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVT 456
E RK I ++ +EK +R E+ +++ L+ + SK++ N+ L R L +
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL-RQLQIQ 1239
Query: 457 IISQDFGDASPRTNGQEADDSSTSEESP 484
+ + P T+ QE+ S+ E P
Sbjct: 1240 -VRESIDGKLPSTDQQESCSSTPGLEEP 1266
Score = 53.5 bits (127), Expect = 1e-06
Identities = 63/323 (19%), Positives = 142/323 (43%), Gaps = 37/323 (11%)
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
L+ Q++ + EL + +LE +K+ + + T + K+ + N EL+
Sbjct: 2236 LKDQLRQMSIHMEELKINISRLEHDKQ---IWESKAQTEVQLQQKVCDTLQGENKELLSQ 2292
Query: 198 KDDNYNLAMRYAQLSEEKNMAVMRS--RDLQLEIDQLKHRLNKMEEEC-KLE---RNQSL 251
++ R+ S + +A + S + L+ ++ L + L K +E+ LE R Q
Sbjct: 2293 LEET-----RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 252 KLKNDIENRPKKEQVLELERE-----NEMLKTKNQELQSIIQAGKRSLPDSDKAILDILE 306
++N + + E L+ RE +E + K Q++ S++ + ++ AI ++ +
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI---QVAIAELRQ 2404
Query: 307 HDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMN 366
KE +EL N + +EE EE K +++ L T+ K+ K +++
Sbjct: 2405 QHDKEI----KELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 367 TVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKD-----------KYRKQIRELEEKND 415
+ + + ++ +RD+ + + ++ ++EKD K +++IR L D
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
Query: 416 EMRIEMVRREACIVNLESKLRRL 438
++ E + +A ++ L ++
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQV 2543
Score = 51.6 bits (122), Expect = 4e-06
Identities = 76/406 (18%), Positives = 162/406 (39%), Gaps = 100/406 (24%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L NE L Q+ KD L+ L++E +M L ++ R K+KE +
Sbjct: 1866 LENEKNTLLSQISTKD-------GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 191 NDELV-KVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
D+L ++ + L ++ A +++ L+ E+ LK ++++EEE + Q
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE----KQQ 1974
Query: 250 SLKLKNDIENRPKKEQVLELEREN-------------EMLKTKNQELQSI---------- 286
+K K +E+ +KE + +++ E+LK K QE++ +
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 287 ---------------------IQAGKRSLPD-------------SDKAILDILEHDRKEA 312
++ K +L S K +LD + +
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 313 LEDRQELVNRIYNLQEEA------------RQAEELRDKYLEEKEDLELKCSTLGKDCEM 360
L D +L + + +E R+ E+ +K+L+EK++++ K L ++
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154
Query: 361 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYS--------------QCLIEKDKYRKQ 406
+ + + + L + ++E Q + D TQ + + + E K+ ++
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 407 IRE-LEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+ ++ K +E+R+ + + C V L+ +LR++S L ++ R
Sbjct: 2215 FSDAIQSKEEEIRL---KEDNCSV-LKDQLRQMSIHMEELKINISR 2256
Score = 50.8 bits (120), Expect = 7e-06
Identities = 92/457 (20%), Positives = 184/457 (40%), Gaps = 50/457 (10%)
Query: 12 METLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQ--CKVIDEQDEDEVLNAPMLPSK 69
M +L+D+ D + + + S I + L++ C V+ +Q ++ L
Sbjct: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKIN 2253
Query: 70 INRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTH 129
I+R I +K Q + + + E +L++ E TR L H
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH------------LYH 2301
Query: 130 FLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMT-LTRVELLTFQER--YYKMKEE 186
NE+ KL+ ++K+ Q +L L + +++K + + R + Q Y+ E
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361
Query: 187 RDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRD--LQLEIDQLKHRLNKMEEECK 244
+ EL + N + E+K ++++ ++ +Q+ I +L+ + +K +E
Sbjct: 2362 DLQASRELTSRLHEEIN-------MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE-- 2412
Query: 245 LERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDI 304
L+N + ++ VLE E + + KT NQ ++++ K ++ KA LD
Sbjct: 2413 --------LENLLSQEEEENIVLEEENKKAVDKT-NQLMETLKTIKKENI--QQKAQLDS 2461
Query: 305 LEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEE--KEDLELKCSTLGKDCEMYK 362
DR +V L+E +D+ ++E E+ +LK G M
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 363 HRMNTVMLQLEEVERERD--QAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420
L E ++ D Q +D Q Q + ++++K ELE K ++ +
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK------ELENKYAKLEEK 2575
Query: 421 MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTI 457
+ E +L L ++ +L + + +L V+I
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEI-ESLKVSI 2611
Score = 47.8 bits (112), Expect = 6e-05
Identities = 68/340 (20%), Positives = 146/340 (42%), Gaps = 49/340 (14%)
Query: 138 LQQQMKAKDLQRCELLARLRQLE---DEKKQMTLTRVELLTFQERYYKMKEER-DSYNDE 193
LQQ++++ LQ L LR+L+ DE +++ + E +++ KE E
Sbjct: 1370 LQQKLESSQLQIAGL-EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKL 253
+++ +D + + QL + R + LQ+E+ ++K + ++ EE + ++ KL
Sbjct: 1429 IIEQED---LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 254 KNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI------------ 301
+ + +R E +EN+ L+ + + I+ +SL D + +
Sbjct: 1486 QAALISRK------EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLG 1539
Query: 302 -LDILEHDRKEALE--DRQELVNR------------IYNLQEE----ARQAEELRDKYLE 342
L +L+ +R + + DR L N+ + L E+ ++ E L+ +
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA 1599
Query: 343 EKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDK 402
E + + K L K+ E+ V + E ++ + + E + K +
Sbjct: 1600 ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKE 1659
Query: 403 YRKQIRELEEKNDEMRIEMVR----REACIVNLESKLRRL 438
KQ++E E++ +EM+ +M + ++ I+ LE + RL
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
Score = 46.6 bits (109), Expect = 1e-04
Identities = 63/343 (18%), Positives = 144/343 (41%), Gaps = 44/343 (12%)
Query: 151 ELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYN-LAMRYA 209
EL ++ LE EK+Q+ E LT ++ K +E++ + E +K + D+YN L ++
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220
Query: 210 QLSEEKNMAVMRSRDLQLEI-DQLKHRLNKMEEECKLERNQSL-----KLKNDIENRPKK 263
+ S+E + R LQ+++ + + +L +++ L K +P
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL 1280
Query: 264 E---------------------QVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAIL 302
E V +++ + + ++ + EL+ + + L + +
Sbjct: 1281 ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVF 1340
Query: 303 DILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLG--KDCEM 360
+ E K+ LE I +L+ + +AE + ++ E +L+ + L ++ +
Sbjct: 1341 QLQEQINKQGLE--------IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQP 1392
Query: 361 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIR---ELEEKNDEM 417
+ ++ + EE ++ A T+ +IE++ K + E++ K +
Sbjct: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
Query: 418 RIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460
RI+ ++ E C ++ K + ++S Q + R L +IS+
Sbjct: 1453 RIKQLQVELC--EMKQKPEEIGEES-RAKQQIQRKLQAALISR 1492
Score = 45.1 bits (105), Expect = 4e-04
Identities = 73/393 (18%), Positives = 159/393 (40%), Gaps = 69/393 (17%)
Query: 100 PELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQL 159
PEL++ E F+ E+ E L + V++L+ ++ KD+Q L + L
Sbjct: 32 PELHQ-----ESDMEFNNTTQEDVQERLA-YAEQLVVELKDIIRQKDVQ---LQQKDEAL 82
Query: 160 EDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAV 219
++E+K +++ L K + S N + ++K + Q E+ +
Sbjct: 83 QEERKAAD-NKIKKLKLHA-----KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHD 136
Query: 220 MRSRDLQLEIDQLKHRLNKMEE------------------ECKLERNQSLKLKNDIENRP 261
S + ++EI+++KH+L + EE + E + + +K ++ +
Sbjct: 137 KSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKE 196
Query: 262 KKEQVLELER--------------------ENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
+ L+ + E ++ +++ LQ + QA + +
Sbjct: 197 EFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRV 256
Query: 302 LDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMY 361
L + +E+L R ++V+ LQ+E AE+ ++ + +E + +TL E
Sbjct: 257 LQRKLEEHEESLVGRAQVVDL---LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 362 KHRMNTVMLQLEEVERERDQAFHSRDEAQ----TQYSQCLIEKDKYRKQIRELEEKNDEM 417
+ ++ ++E ER +FH+ E Q+ Q + + + LE+K+
Sbjct: 314 REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKH--- 370
Query: 418 RIEMVRREACIVNLESKLRRLS------KDSNN 444
+ EM + + I++L+ + L KD N+
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSACDALKDQNS 403
Score = 44.7 bits (104), Expect = 5e-04
Identities = 61/265 (23%), Positives = 108/265 (40%), Gaps = 36/265 (13%)
Query: 129 HFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKK-QMTLTRVELLTFQERYYKMKEER 187
H L E+ L +Q + + EL +R LE + K +M +L+ Q+ +++
Sbjct: 336 HNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSAC 395
Query: 188 DSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECK--- 244
D+ D+ K+ D A++ AQ ++ + + EI Q +RL + E
Sbjct: 396 DALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSK---EISQFLNRLPLQQHETASQT 452
Query: 245 -------------LERNQSLKLKNDIENRPKKEQVL-------ELERENEMLKTKNQELQ 284
E N + K +E +K +L EL+ ENE L ++ L+
Sbjct: 453 SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512
Query: 285 SIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEK 344
+ + G+ S+ +I+DI A E Q+++ + +++ +EL LE K
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTF-----SQKHKELSVLLLEMK 567
Query: 345 EDLE----LKCSTLGKDCEMYKHRM 365
E E LK GK E H +
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEV 592
Score = 44.3 bits (103), Expect = 7e-04
Identities = 70/337 (20%), Positives = 138/337 (40%), Gaps = 46/337 (13%)
Query: 144 AKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYN 203
A+DL E+ +L + E K +T ++ +F ++ RD N+EL ++K
Sbjct: 2709 ARDL--VEMEQKLLMVTKENKGLT---AQIQSFGRSMSSLQNSRDHANEELDELKRKYDA 2763
Query: 204 LAMRYAQLSEEKNMAVMRSRDLQL----------EIDQLKHRLNKMEEECKLERNQSLKL 253
AQL E+ + R RD L E + L H L K+ ++ + Q L L
Sbjct: 2764 SLKELAQLKEQG--LLNRERDALLSETAFSMNSTEENSLSH-LEKLNQQLLSKDEQLLHL 2820
Query: 254 KNDIENRPKKEQ-----VLELERENEMLKTKNQELQSIIQAGKRSL--PDSDKAILDILE 306
+ +E+ + Q + L+ E + L + ++ + + +RS P + A + L+
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 307 HDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMN 366
DR L+ + NLQ++ YL+ +++ + L + Y+ +
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQ----------YLQINQEI-TELHPLKAQLQEYQDKTK 2929
Query: 367 TVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ-IRELEEKNDEMRIEMVRRE 425
+ EE+ +E H + + + S I + + ++Q + + +K+ ++
Sbjct: 2930 AFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL-------- 2981
Query: 426 ACIVNLESKLRRLSKDSNNLDQSLPRNL-PVTIISQD 461
+ + NL +LR S + L R P T S D
Sbjct: 2982 SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPD 3018
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/346 (18%), Positives = 140/346 (40%), Gaps = 49/346 (14%)
Query: 140 QQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLT-FQERYYKMKEERDSYNDELVKVK 198
+ M + R ++ +QLE+ + L + +L+ K+KEE + +
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523
Query: 199 DDNYNLAMRYAQLSEEKNMAV-----MRSRDLQLEIDQ---LKHRLNKMEEECKL--ERN 248
+N L Q E+ N + + + L++++ Q L+++ K+EE+ K E N
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN 2583
Query: 249 QSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHD 308
+ L+ + K++ E+E + +++ ++ + G L + + + H
Sbjct: 2584 EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR 2643
Query: 309 RKEALEDRQELVNRIYNLQEE--------ARQAEELRDKYLEEKEDLELKCSTLGKDCEM 360
Q+ RI L+EE A++ E+ DK +E + L + + E
Sbjct: 2644 LSALFSSSQK---RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
Query: 361 YKHRMNTVMLQLEEVERE-------------RDQAF--------HSRDEAQTQYSQCLIE 399
+ R+ + L E+E++ + Q+F +SRD A + + +
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760
Query: 400 KDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNL 445
D K++ +L+E+ ++ RE + E+ S + N+L
Sbjct: 2761 YDASLKELAQLKEQG------LLNRERDALLSETAFSMNSTEENSL 2800
Score = 40.8 bits (94), Expect = 0.008
Identities = 47/226 (20%), Positives = 98/226 (43%), Gaps = 27/226 (11%)
Query: 228 EIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSII 287
+IDQLK R+ +EEE + + S L+N E Q+ + E +ML+ + ++ +
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLEN--EKNTLLSQISTKDGELKMLQEEVTKMNLLN 1898
Query: 288 QAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDL 347
Q + L K L + K+ LE+R L+N++ L Y ++ D
Sbjct: 1899 QQIQEELSRVTK--LKETAEEEKDDLEER--LMNQLAELNGSI-------GNYCQDVTDA 1947
Query: 348 ELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDK----- 402
++K E+ + M + + E+E E+ Q + + +++ + +EK +
Sbjct: 1948 QIK-------NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000
Query: 403 --YRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD 446
+ +EL+E E + E+ + + + + K+ L + L+
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046
Score = 40.4 bits (93), Expect = 0.010
Identities = 63/323 (19%), Positives = 146/323 (45%), Gaps = 37/323 (11%)
Query: 132 MNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYN 191
++ V +L+ Q+K ++ E R R+L+ E + LLT Q ++ +
Sbjct: 756 LSMVTELRAQVKQLEMNLAEA-ERQRRLDYESQT---AHDNLLTEQIHSLSIEAKSKDVK 811
Query: 192 DELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSL 251
E+++ + D+ L Q SE+ + R LQ QL+++ +++ E + R+ S
Sbjct: 812 IEVLQNELDDVQL-----QFSEQSTLI----RSLQ---SQLQNKESEVLEGAERVRHISS 859
Query: 252 KLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDI---LEHD 308
K++ + +KE LE+ + +++L K ++++++ Q ++ + D+ + +I +
Sbjct: 860 KVEELSQALSQKE--LEITKMDQLLLEKKRDVETLQQ----TIEEKDQQVTEISFSMTEK 913
Query: 309 RKEALEDRQELVNRIYNLQEEAR---QAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRM 365
+ E++ L I L+E+ +AEE + + +EE ++ + Y
Sbjct: 914 MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK------QNYDEMS 967
Query: 366 NTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRRE 425
+ EE++ E D ++ + + LI + + +++ LEE+ ++ E +
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE- 1026
Query: 426 ACIVNLESKLRRLSKDSNNLDQS 448
I E++ + +D N + S
Sbjct: 1027 --IPLSETERGEVEEDKENKEYS 1047
Score = 38.1 bits (87), Expect = 0.049
Identities = 77/370 (20%), Positives = 144/370 (38%), Gaps = 48/370 (12%)
Query: 119 VVEEGHEGLTH----FLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELL 174
V EG + +T L V++L+ + A L EL + E Q+TL +
Sbjct: 457 VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNR 516
Query: 175 TFQ-ERYYKMKEERDSYNDELVKVKDDNYN-LAMRYAQLSEEKNMAVMRSRDLQLEIDQL 232
T + +R D N ++ + L ++Q +E ++ ++ ++ Q EI L
Sbjct: 517 TGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
Query: 233 KHRLN-KMEEECKLERNQSLKLKN--------------------DIENRPKKEQVL---E 268
K +L K EE E ++K D P +E L E
Sbjct: 577 KLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE 636
Query: 269 LERENEMLKTKNQELQSIIQAG---KRSLPDSDKAILDILEHDRKEALEDRQELVNRIYN 325
E+ + +++ E S+ AG K + D DK++ + + + ++ + L ++I
Sbjct: 637 KEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ-DELERLKSQILE 695
Query: 326 LQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHS 385
L+ +A+E+ +K L+EK + S L + E +K + + ERDQ
Sbjct: 696 LELNFHKAQEIYEKNLDEKAK---EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
Query: 386 RDEAQ---------TQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLR 436
E Q L E ++ R+ E + +D + E + + + +SK
Sbjct: 753 VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIEAKSKDV 810
Query: 437 RLSKDSNNLD 446
++ N LD
Sbjct: 811 KIEVLQNELD 820
Score = 37.7 bits (86), Expect = 0.064
Identities = 58/309 (18%), Positives = 131/309 (42%), Gaps = 27/309 (8%)
Query: 133 NEVIKLQ-QQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQER--YYKMKEERDS 189
N+++ Q QQM+A+ L + E E+ ++ L ++EL + + ++ ++EE
Sbjct: 289 NQILSQQLQQMEAEH----NTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH 344
Query: 190 YNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
++ + L RY+ L E+K+ A M + I L+ +++ C ++Q
Sbjct: 345 LLEQFEQAGQAQAELESRYSAL-EQKHKAEMEEK--TSHILSLQKTGQELQSACDALKDQ 401
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQ---------AGKRSLPDSDKA 300
+ KL D +N + +++ + L+ K++E+ + A + S PD
Sbjct: 402 NSKLLQD-KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNE 460
Query: 301 ILDILEHDRKEALEDR-QELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCE 359
+ + +L+ R EL N L + + EEL+ E E L + + L
Sbjct: 461 GTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK----AENEKLSSQITLLEAQNR 516
Query: 360 MYKHRMNTVMLQLEEVERERDQAFH--SRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEM 417
+ + + ++ +R + +D + +SQ E +++E +E+ +
Sbjct: 517 TGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
Query: 418 RIEMVRREA 426
++++ + A
Sbjct: 577 KLQLQGKRA 585
Score = 35.0 bits (79), Expect = 0.41
Identities = 38/211 (18%), Positives = 91/211 (43%), Gaps = 17/211 (8%)
Query: 150 CELLARLRQLEDEKKQMTLTRVELLT---------FQERYYKMKEERDSYNDELVKVKDD 200
CE L + E K+ + +E L +QE++ ++++E + V ++
Sbjct: 1569 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE 1628
Query: 201 NYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENR 260
+ + +EK + R + + + +L + E+E + + + K +
Sbjct: 1629 AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA-----K 1683
Query: 261 PKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKE---ALEDRQ 317
K++++LELE EN+ L+ + + +L S+ ++ + LE + E + Q
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 318 ELVNRIYNLQEEARQAEELRDKYLEEKEDLE 348
L++ +L EE + + + + ++ +LE
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLE 1774
>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
Length = 284
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/289 (23%), Positives = 134/289 (46%), Gaps = 27/289 (9%)
Query: 177 QERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRL 236
+++ +K ++++ D + + D R QL EE+ + + + E+++ +
Sbjct: 5 KKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESV 64
Query: 237 NKMEEECKLERNQSLKLKNDIENRPKKEQVLE--LERENEMLKTKNQELQSIIQAGKRSL 294
+ +E+ + ++ + D+ + ++ Q++E L+R E L T Q+L+ +A
Sbjct: 65 KEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA---- 120
Query: 295 PDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTL 354
D + + ++E+ A++D +++ + L+E AE+ KY E++ K L
Sbjct: 121 -DESERGMKVIEN---RAMKDEEKMELQEMQLKEAKHIAEDSDRKY----EEVARKLVIL 172
Query: 355 GKDCEMYKHRMNTV---MLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELE 411
+ E + R QLEE R DQA S ++ +YS ++DKY ++I+ LE
Sbjct: 173 EGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYST---KEDKYEEEIKLLE 229
Query: 412 E--KNDEMRIEMVRR-----EACIVNLESKLRRLSKDSNNLDQSLPRNL 453
E K E R E R E I +LE L +++ + Q+L + L
Sbjct: 230 EKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTL 278
Score = 32.0 bits (71), Expect = 3.5
Identities = 56/265 (21%), Positives = 105/265 (39%), Gaps = 41/265 (15%)
Query: 7 EMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPML 66
+ +D + L++E+ AL + ++ + +Y K + + EQ E + +A
Sbjct: 31 QAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVK------EAQEKLEQAEKKATDAEAD 84
Query: 67 PSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRF--STIVVEEGH 124
+ +NR +L++ + Q L+ LE E K E + + + +E
Sbjct: 85 VASLNRRIQLVEEELDRAQERLATALQKLE----EAEKAADESERGMKVIENRAMKDEEK 140
Query: 125 EGLTHFLMNEVIKLQQQMKAK-------------DLQRCELLA-----RLRQLEDEKKQM 166
L + E + + K +L+R E A R RQLE+E + M
Sbjct: 141 MELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTM 200
Query: 167 TLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQ 226
L+ +E Y + D Y +E +K+ ++ A A+ +E L+
Sbjct: 201 DQALKSLMASEEEY---STKEDKYEEE-IKLLEEKLKEAETRAEFAERS------VAKLE 250
Query: 227 LEIDQLKHRLNKMEEECKLERNQSL 251
ID L+ L +EE +E +Q+L
Sbjct: 251 KTIDDLEETLASAKEE-NVEIHQTL 274
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.0 bits (162), Expect = 1e-10
Identities = 72/360 (20%), Positives = 163/360 (45%), Gaps = 58/360 (16%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L E +LQQQ + K+ +L + + QL + + T +L E + ++KE+R
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE---TERQL---GEAHGRLKEQRQLS 444
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQS 250
+++L+ + +L ++ ++L E+ V S +LQ ++D+ K + +E+ L+++ +
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK---QQHQEQQALQQSTT 501
Query: 251 LKLK---NDIENRPKK-----------EQVLELEREN-EMLKTKNQELQSIIQAGKRSLP 295
KL+ ND+E ++ E +L+ +EN +L+ + ++L + IQAG
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG----- 556
Query: 296 DSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEE-LRDKYLEEKE--------- 345
+ + A+L+ L+ E +L ++ N E +QA+E L D+ E+K
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 346 -DLELKCSTLGKDCEMYKHRMNTVMLQLE------------------EVERERDQAFHSR 386
LE + L K +++ + +Q++ +++ D A ++
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 387 DEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLD 446
+ Q + ++ + D+ ++++ +E ++ + + ++LE K L L+
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Score = 56.6 bits (135), Expect = 1e-07
Identities = 71/328 (21%), Positives = 140/328 (42%), Gaps = 40/328 (12%)
Query: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
LQQQ + +QLE EK+ ++ TR++L E +K++ +E +
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 198 KDDNYNLAMRYAQLSEEKNMAV-----------MRSRDLQLEIDQLKHRLNKMEEECKLE 246
K D L+ EE N + M L E+ +K +L+K+ + K
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 247 RNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQ-ELQSIIQAG---KRSLPDSDKAIL 302
+++ K EN+ K +L+LE+ + LK + Q ++++ ++ K+SL +A
Sbjct: 873 KSEFEK-----ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA-- 925
Query: 303 DILEHDRKEALEDRQE-LVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMY 361
H K L QE L+ L++ ++ ++L+ E K+ E K K E
Sbjct: 926 ---SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK----KKQIEAL 978
Query: 362 KHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEM 421
+ + +LQ E+E ++ Q Q +Q E +++I L+ ++ +
Sbjct: 979 QGELKIAVLQKTELE----------NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028
Query: 422 VRREACIVNLESKLRRLSKDSNNLDQSL 449
+ ++ ES+L +D ++++ L
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKL 1056
Score = 53.1 bits (126), Expect = 1e-06
Identities = 74/349 (21%), Positives = 153/349 (43%), Gaps = 68/349 (19%)
Query: 134 EVIKLQQQMKAKDLQRCELLARLRQ-LEDEKKQMTLTRVELLTFQERYYKMKE-----ER 187
++ LQ ++K LQ+ EL +L+Q L +++ + ++ Q Y K +E +
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 188 DSYN--DELVKVKDD----NYNLAMRYAQLSEEKNMAVMRSRDLQ--------LEIDQLK 233
D Y EL+ + D L++ L +N +++ +Q LE D K
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK 1093
Query: 234 HRLNKMEEECK----LERNQSLKLKNDIENRPKKEQVLELE--RENEMLKT----KNQEL 283
+++E CK +++ +SLK K + + K ++ E++ +E E+ K K+ +L
Sbjct: 1094 KE-QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 284 QSI-----IQAGKRSL----------PDSDKAILD--------ILEHDRKEALEDRQELV 320
+SI ++ K+ L DS KA ++ + + +KE E ++E +
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 321 NRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERD 380
+ L E ++ E K+ E + L ++ + L ++ K + ++ E+E++ D
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 381 Q-----------AFHSRDEAQTQYSQCLI---EKDKYRKQIRELEEKND 415
+++DE + +CL E +K + ++ EL+ K D
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Score = 50.4 bits (119), Expect = 9e-06
Identities = 50/288 (17%), Positives = 115/288 (39%), Gaps = 38/288 (13%)
Query: 186 ERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ-------LKHRLNK 238
E S +L + + +N+N+ ++ D++ + D+ + ++ +
Sbjct: 136 ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
Query: 239 MEEECKLERNQSLKLKNDIENRP--------KKEQV----------LELERENEMLKTKN 280
+ EE E LK ++ RP KKE V LE ERE+E LK +
Sbjct: 196 LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
Query: 281 QELQSIIQAGKRSLPDSDKAI-------------LDILEHDRKEALEDRQELVNRIYNLQ 327
++LQS + + ++ + L L+ E + Q L + +
Sbjct: 256 KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
Query: 328 EEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRD 387
++ + EE ++ K++++ DC+ + R++ L + E + +
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375
Query: 388 EAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKL 435
+ + + S+ + + + ++L+++ +E ++ ++ I L SKL
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Score = 50.4 bits (119), Expect = 9e-06
Identities = 73/365 (20%), Positives = 157/365 (43%), Gaps = 34/365 (9%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L +++ K +QQ + + + A+LR+ +++ +Q+ R K+++
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL-----------RQIGDKDQKIQN 527
Query: 191 NDELVKVKDDNYNLAMR-----YAQLSE-EKNMAVM-----RSRDLQLEIDQLKHRL-NK 238
+ L++ +N +L + YA++ E AV+ ++ LQ ++ QL +L N+
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 239 MEEECKLERNQSLKLKNDIEN-RPKKEQVLELERE-NEMLKTKNQELQSIIQA-----GK 291
E + + N +++ + R +++VL LE NE+ N+ + + Q K
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
Query: 292 RSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKC 351
L S +A D + L+ Q N + + Q+E + D+ + +D + C
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQ---NALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 352 STLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELE 411
S L + YK + ++ + EE+E + + E + Q L + + R+ +LE
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
Query: 412 EKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR-NLPVTIISQDFGDASPRTN 470
+ E+ ++ + + + L++ S+ ++ Q L + I+ QDF S T
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
Query: 471 GQEAD 475
Q +
Sbjct: 825 IQHEE 829
Score = 48.5 bits (114), Expect = 4e-05
Identities = 60/319 (18%), Positives = 143/319 (44%), Gaps = 32/319 (10%)
Query: 137 KLQQQMKAKDLQRCELLARLRQLEDE----KKQMTLTRVELLTFQERYYKMKEERDSYND 192
KL+ + K Q A + QL E +++ + EL + ++ ++ + +
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 193 ELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLK 252
L+K + D Y +L E+ N + +++Q + Q L+ + + +L +++
Sbjct: 310 NLLKKEQD-------YTKLEEKHNEESVSKKNIQATLHQKD--LDCQQLQSRLSASETSL 360
Query: 253 LKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDI---LEHDR 309
+ +E K E +L+ E ++TK Q L++ + ++ + ++ L + +
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 310 KEALEDRQELVNRIYNLQEEAR-QAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTV 368
+ LE ++L L+E+ + +E+L DK ++ DL+LK S L +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKE-QQVADLQLKLSRLEE------------ 467
Query: 369 MLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACI 428
QL+E + H D+ + Q+ + + ++RE + +++ ++ ++ I
Sbjct: 468 --QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 429 VNLESKLRRLSKDSNNLDQ 447
NLE+ L++ ++ + L++
Sbjct: 526 QNLEALLQKSKENISLLEK 544
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 67.0 bits (162), Expect = 1e-10
Identities = 72/340 (21%), Positives = 142/340 (41%), Gaps = 30/340 (8%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L + LQ+ + ++ R + + R L +E + + + L +++ +R+
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 191 NDELVKVKDDN--------YNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEE 242
L K D+ + ++AQ EE + + + + +D+ K L K +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 243 CKLERNQSLKLKNDIENRPKK--EQVLEL-------ERENEMLKTKNQELQSIIQA---- 289
E + K ++E++ KK QV EL ER L K +LQ+ +++
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 290 -----GKRSLPDSDKAILDILEHDRKEALED--RQEL--VNRIYNLQEEARQAEELRDKY 340
GK D A L D +E L++ RQ+L ++ L+EE ++ D+
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 341 LEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
+E K++LE STL K ++ +E +E + + + QY +
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSK 440
DK K L+++ D++ +++ + + NLE K R+ +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 64.7 bits (156), Expect = 5e-10
Identities = 80/361 (22%), Positives = 159/361 (44%), Gaps = 37/361 (10%)
Query: 137 KLQQQMKA-KDLQR-CELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKE-ERDSYNDE 193
K QQQ+ A K +QR C +LR + + + + +T QE + KE E +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNM---AVMRSRDLQLEIDQLKHRL----NKMEE----- 241
K +++ L +++QL+EEKN+ + +L E ++++ RL ++EE
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 242 ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
E +LE + + E + +Q+L+LE + E + Q+LQ + + + I
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 302 LDILEHDRKEALEDRQELVNRIYNL-------QEEARQAEELRDKY------------LE 342
L +++ + ++R+ L RI +L +E+A+ +L++K+ E
Sbjct: 988 L-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046
Query: 343 EK--EDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
EK ++LE L D + ++ + Q+ E++ + + A + + +K
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460
+ K+IRELE +++ ++ A E + R L ++ L L L T Q
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 461 D 461
+
Sbjct: 1167 E 1167
Score = 55.1 bits (131), Expect = 4e-07
Identities = 90/386 (23%), Positives = 167/386 (43%), Gaps = 52/386 (13%)
Query: 104 KLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEK 163
+L K+ + F++ VE EG F E+ L QQ + K +L +L+ E
Sbjct: 1372 QLSDSKKKLQDFAS-TVEALEEGKKRF-QKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKD------DNYNLAMRYAQLSEEKNM 217
+ V+L ++ +++++ ++ L + K+ D + A A+ E K +
Sbjct: 1430 DDLV---VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 218 AVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE--LERENEM 275
++ R+ + LE + R NKM K E + K+D+ + + + LE + E
Sbjct: 1487 SLARALEEALEAKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 276 LKTKNQELQSIIQA---GKRSLPDSDKAILDILEHD---RKEALEDRQELVNRIYN---- 325
+KT+ +EL+ +QA K L + +A+ E D R E E+++ + R +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 326 -LQEEARQ---AEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQ 381
L++E +Q A + K + +DLEL+ + K E ++ + Q+++ +RE +
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 382 AFHSRDEA-----------------QTQYSQCLIEKDKYRKQI-RELEEKNDEMRIEMVR 423
A SRDE Q + L ++ RKQ E EE +E+ +
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R A L+ + RRL L++ L
Sbjct: 1724 RNA----LQDEKRRLEARIAQLEEEL 1745
Score = 55.1 bits (131), Expect = 4e-07
Identities = 60/275 (21%), Positives = 124/275 (45%), Gaps = 22/275 (8%)
Query: 132 MNEVIKLQQQMK--AKDLQ-----RCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMK 184
+ ++ KLQ QMK ++L+ R E+ A + E+EKK +L +L+ QE +
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAK--ENEKKAKSL-EADLMQLQEDLAAAE 1700
Query: 185 EERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECK 244
R + E ++ ++ + L +EK R L+ E+++ + + M + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 245 LERNQSLKLKNDIENRPKKEQVLE-----LERENEMLKTKNQELQSIIQAGKRSLPDSDK 299
Q+ +L N++ Q E LER+N+ L++K E++ +++ +S + +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 300 AILDILEHDRKEALEDRQ----ELVNRIYNLQEEARQAEELR---DKYLEEKEDLELKCS 352
A + LE ++ ++Q L + L+E Q E+ R ++Y E+ E +
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 353 TLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRD 387
L + E + + +++RE D+A S +
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Score = 54.3 bits (129), Expect = 7e-07
Identities = 67/364 (18%), Positives = 153/364 (42%), Gaps = 39/364 (10%)
Query: 119 VVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC---ELLARLRQLEDEKKQMTLTRVEL-- 173
++EE LT L E K + K K+ EL RL++ E ++++ + +L
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 174 --LTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ 231
F E+ ++ + +L K +++ R +KN A+ + R+L+ I
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 232 LKHRLNKMEEECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTKNQELQSI 286
L+ L+ + RN++ K K D+ + + E L+ + L+ K ++ ++
Sbjct: 1123 LQEDLDSE----RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 287 IQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKED 346
+ K++L + ++ ++ R++ + +EL ++ + ++ + +E D
Sbjct: 1179 L---KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 347 LELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ 406
L + LG+ + +H+ + Q++E++ + +R E + + E +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 407 IRELEEK-----------------NDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ E E K E+ E R++ +N+ +KLR+L ++ N+L L
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQL 1352
Query: 450 PRNL 453
+
Sbjct: 1353 DEEM 1356
Score = 47.0 bits (110), Expect = 1e-04
Identities = 74/386 (19%), Positives = 161/386 (41%), Gaps = 76/386 (19%)
Query: 135 VIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTR----VELLTFQERYYKMKEERDSY 190
V +L++ +A + Q E+ +L +LEDE + + V + + ++ + + RD
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS----------RDLQLEIDQ-LKHRLNKM 239
N+E K + L +L +E+ + + +DL+L+ D +K R +
Sbjct: 1587 NEE--KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 240 EEECKLERNQSLKLKNDIEN-RPKKEQVLELERENEM----LKTKNQELQSIIQAGKRSL 294
++ KL+ Q + ++E+ R ++++ +ENE L+ +LQ + A +R+
Sbjct: 1645 KQLRKLQA-QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 295 PDSDKAILDILEH-----DRKEALED-RQELVNRIYNLQEE------------------A 330
+D ++ E + AL+D ++ L RI L+EE
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 331 RQAEELRDKYLEEK------EDLELKCSTLGKDCEMYKHRMNTVML-------------- 370
+QAE+L ++ E+ E + K+ H M +
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 371 -----QLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE--MRIEMVR 423
Q+E+ RE+ A S + + + L++ + RK + +E+ ++ R++ ++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R+ + E + +R++ + L + L
Sbjct: 1884 RQ--LEEAEEESQRINANRRKLQREL 1907
Score = 32.7 bits (73), Expect = 2.0
Identities = 31/128 (24%), Positives = 60/128 (46%), Gaps = 19/128 (14%)
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
L A++ QLE++ +Q E Q +K++ + L++V+D+ +A +Y +
Sbjct: 1819 LEAKIAQLEEQVEQ------EAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQ 1871
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELER 271
+E+ N V QLK +L + EEE + KL+ +++ + + + R
Sbjct: 1872 AEKGNARVK----------QLKRQLEEAEEESQRINANRRKLQRELDEATESNEA--MGR 1919
Query: 272 ENEMLKTK 279
E LK+K
Sbjct: 1920 EVNALKSK 1927
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 67.0 bits (162), Expect = 1e-10
Identities = 72/340 (21%), Positives = 142/340 (41%), Gaps = 30/340 (8%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L + LQ+ + ++ R + + R L +E + + + L +++ +R+
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 191 NDELVKVKDDN--------YNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEE 242
L K D+ + ++AQ EE + + + + +D+ K L K +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 243 CKLERNQSLKLKNDIENRPKK--EQVLEL-------ERENEMLKTKNQELQSIIQA---- 289
E + K ++E++ KK QV EL ER L K +LQ+ +++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 290 -----GKRSLPDSDKAILDILEHDRKEALED--RQEL--VNRIYNLQEEARQAEELRDKY 340
GK D A L D +E L++ RQ+L ++ L+EE ++ D+
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 341 LEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
+E K++LE STL K ++ +E +E + + + QY +
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSK 440
DK K L+++ D++ +++ + + NLE K R+ +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 64.7 bits (156), Expect = 5e-10
Identities = 80/361 (22%), Positives = 159/361 (44%), Gaps = 37/361 (10%)
Query: 137 KLQQQMKA-KDLQR-CELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKE-ERDSYNDE 193
K QQQ+ A K +QR C +LR + + + + +T QE + KE E +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNM---AVMRSRDLQLEIDQLKHRL----NKMEE----- 241
K +++ L +++QL+EEKN+ + +L E ++++ RL ++EE
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 242 ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
E +LE + + E + +Q+L+LE + E + Q+LQ + + + I
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 302 LDILEHDRKEALEDRQELVNRIYNL-------QEEARQAEELRDKY------------LE 342
L +++ + ++R+ L RI +L +E+A+ +L++K+ E
Sbjct: 995 L-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053
Query: 343 EK--EDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
EK ++LE L D + ++ + Q+ E++ + + A + + +K
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460
+ K+IRELE +++ ++ A E + R L ++ L L L T Q
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 461 D 461
+
Sbjct: 1174 E 1174
Score = 55.1 bits (131), Expect = 4e-07
Identities = 90/386 (23%), Positives = 167/386 (43%), Gaps = 52/386 (13%)
Query: 104 KLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEK 163
+L K+ + F++ VE EG F E+ L QQ + K +L +L+ E
Sbjct: 1379 QLSDSKKKLQDFAS-TVEALEEGKKRF-QKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKD------DNYNLAMRYAQLSEEKNM 217
+ V+L ++ +++++ ++ L + K+ D + A A+ E K +
Sbjct: 1437 DDLV---VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 218 AVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE--LERENEM 275
++ R+ + LE + R NKM K E + K+D+ + + + LE + E
Sbjct: 1494 SLARALEEALEAKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 276 LKTKNQELQSIIQA---GKRSLPDSDKAILDILEHD---RKEALEDRQELVNRIYN---- 325
+KT+ +EL+ +QA K L + +A+ E D R E E+++ + R +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 326 -LQEEARQ---AEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQ 381
L++E +Q A + K + +DLEL+ + K E ++ + Q+++ +RE +
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 382 AFHSRDEA-----------------QTQYSQCLIEKDKYRKQI-RELEEKNDEMRIEMVR 423
A SRDE Q + L ++ RKQ E EE +E+ +
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R A L+ + RRL L++ L
Sbjct: 1731 RNA----LQDEKRRLEARIAQLEEEL 1752
Score = 55.1 bits (131), Expect = 4e-07
Identities = 60/275 (21%), Positives = 124/275 (45%), Gaps = 22/275 (8%)
Query: 132 MNEVIKLQQQMK--AKDLQ-----RCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMK 184
+ ++ KLQ QMK ++L+ R E+ A + E+EKK +L +L+ QE +
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAK--ENEKKAKSL-EADLMQLQEDLAAAE 1707
Query: 185 EERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECK 244
R + E ++ ++ + L +EK R L+ E+++ + + M + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 245 LERNQSLKLKNDIENRPKKEQVLE-----LERENEMLKTKNQELQSIIQAGKRSLPDSDK 299
Q+ +L N++ Q E LER+N+ L++K E++ +++ +S + +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 300 AILDILEHDRKEALEDRQ----ELVNRIYNLQEEARQAEELR---DKYLEEKEDLELKCS 352
A + LE ++ ++Q L + L+E Q E+ R ++Y E+ E +
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 353 TLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRD 387
L + E + + +++RE D+A S +
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Score = 54.3 bits (129), Expect = 7e-07
Identities = 67/364 (18%), Positives = 153/364 (42%), Gaps = 39/364 (10%)
Query: 119 VVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC---ELLARLRQLEDEKKQMTLTRVEL-- 173
++EE LT L E K + K K+ EL RL++ E ++++ + +L
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 174 --LTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ 231
F E+ ++ + +L K +++ R +KN A+ + R+L+ I
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 232 LKHRLNKMEEECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTKNQELQSI 286
L+ L+ + RN++ K K D+ + + E L+ + L+ K ++ ++
Sbjct: 1130 LQEDLDSE----RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 287 IQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKED 346
+ K++L + ++ ++ R++ + +EL ++ + ++ + +E D
Sbjct: 1186 L---KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 347 LELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ 406
L + LG+ + +H+ + Q++E++ + +R E + + E +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 407 IRELEEK-----------------NDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ E E K E+ E R++ +N+ +KLR+L ++ N+L L
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQL 1359
Query: 450 PRNL 453
+
Sbjct: 1360 DEEM 1363
Score = 47.0 bits (110), Expect = 1e-04
Identities = 74/386 (19%), Positives = 161/386 (41%), Gaps = 76/386 (19%)
Query: 135 VIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTR----VELLTFQERYYKMKEERDSY 190
V +L++ +A + Q E+ +L +LEDE + + V + + ++ + + RD
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS----------RDLQLEIDQ-LKHRLNKM 239
N+E K + L +L +E+ + + +DL+L+ D +K R +
Sbjct: 1594 NEE--KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 240 EEECKLERNQSLKLKNDIEN-RPKKEQVLELERENEM----LKTKNQELQSIIQAGKRSL 294
++ KL+ Q + ++E+ R ++++ +ENE L+ +LQ + A +R+
Sbjct: 1652 KQLRKLQA-QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 295 PDSDKAILDILEH-----DRKEALED-RQELVNRIYNLQEE------------------A 330
+D ++ E + AL+D ++ L RI L+EE
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 331 RQAEELRDKYLEEK------EDLELKCSTLGKDCEMYKHRMNTVML-------------- 370
+QAE+L ++ E+ E + K+ H M +
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 371 -----QLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE--MRIEMVR 423
Q+E+ RE+ A S + + + L++ + RK + +E+ ++ R++ ++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R+ + E + +R++ + L + L
Sbjct: 1891 RQ--LEEAEEESQRINANRRKLQREL 1914
Score = 32.7 bits (73), Expect = 2.0
Identities = 31/128 (24%), Positives = 60/128 (46%), Gaps = 19/128 (14%)
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
L A++ QLE++ +Q E Q +K++ + L++V+D+ +A +Y +
Sbjct: 1826 LEAKIAQLEEQVEQ------EAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQ 1878
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELER 271
+E+ N V QLK +L + EEE + KL+ +++ + + + R
Sbjct: 1879 AEKGNARVK----------QLKRQLEEAEEESQRINANRRKLQRELDEATESNEA--MGR 1926
Query: 272 ENEMLKTK 279
E LK+K
Sbjct: 1927 EVNALKSK 1934
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.0 bits (162), Expect = 1e-10
Identities = 72/340 (21%), Positives = 142/340 (41%), Gaps = 30/340 (8%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L + LQ+ + ++ R + + R L +E + + + L +++ +R+
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 191 NDELVKVKDDN--------YNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEE 242
L K D+ + ++AQ EE + + + + +D+ K L K +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 243 CKLERNQSLKLKNDIENRPKK--EQVLEL-------ERENEMLKTKNQELQSIIQA---- 289
E + K ++E++ KK QV EL ER L K +LQ+ +++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 290 -----GKRSLPDSDKAILDILEHDRKEALED--RQEL--VNRIYNLQEEARQAEELRDKY 340
GK D A L D +E L++ RQ+L ++ L+EE ++ D+
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 341 LEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
+E K++LE STL K ++ +E +E + + + QY +
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSK 440
DK K L+++ D++ +++ + + NLE K R+ +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 64.7 bits (156), Expect = 5e-10
Identities = 80/361 (22%), Positives = 159/361 (44%), Gaps = 37/361 (10%)
Query: 137 KLQQQMKA-KDLQR-CELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKE-ERDSYNDE 193
K QQQ+ A K +QR C +LR + + + + +T QE + KE E +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNM---AVMRSRDLQLEIDQLKHRL----NKMEE----- 241
K +++ L +++QL+EEKN+ + +L E ++++ RL ++EE
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 242 ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
E +LE + + E + +Q+L+LE + E + Q+LQ + + + I
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 302 LDILEHDRKEALEDRQELVNRIYNL-------QEEARQAEELRDKY------------LE 342
L +++ + ++R+ L RI +L +E+A+ +L++K+ E
Sbjct: 995 L-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053
Query: 343 EK--EDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
EK ++LE L D + ++ + Q+ E++ + + A + + +K
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460
+ K+IRELE +++ ++ A E + R L ++ L L L T Q
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 461 D 461
+
Sbjct: 1174 E 1174
Score = 55.1 bits (131), Expect = 4e-07
Identities = 90/386 (23%), Positives = 167/386 (43%), Gaps = 52/386 (13%)
Query: 104 KLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEK 163
+L K+ + F++ VE EG F E+ L QQ + K +L +L+ E
Sbjct: 1379 QLSDSKKKLQDFAS-TVEALEEGKKRF-QKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKD------DNYNLAMRYAQLSEEKNM 217
+ V+L ++ +++++ ++ L + K+ D + A A+ E K +
Sbjct: 1437 DDLV---VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 218 AVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE--LERENEM 275
++ R+ + LE + R NKM K E + K+D+ + + + LE + E
Sbjct: 1494 SLARALEEALEAKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 276 LKTKNQELQSIIQA---GKRSLPDSDKAILDILEHD---RKEALEDRQELVNRIYN---- 325
+KT+ +EL+ +QA K L + +A+ E D R E E+++ + R +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 326 -LQEEARQ---AEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQ 381
L++E +Q A + K + +DLEL+ + K E ++ + Q+++ +RE +
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 382 AFHSRDEA-----------------QTQYSQCLIEKDKYRKQI-RELEEKNDEMRIEMVR 423
A SRDE Q + L ++ RKQ E EE +E+ +
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R A L+ + RRL L++ L
Sbjct: 1731 RNA----LQDEKRRLEARIAQLEEEL 1752
Score = 55.1 bits (131), Expect = 4e-07
Identities = 60/275 (21%), Positives = 124/275 (45%), Gaps = 22/275 (8%)
Query: 132 MNEVIKLQQQMK--AKDLQ-----RCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMK 184
+ ++ KLQ QMK ++L+ R E+ A + E+EKK +L +L+ QE +
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAK--ENEKKAKSL-EADLMQLQEDLAAAE 1707
Query: 185 EERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECK 244
R + E ++ ++ + L +EK R L+ E+++ + + M + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 245 LERNQSLKLKNDIENRPKKEQVLE-----LERENEMLKTKNQELQSIIQAGKRSLPDSDK 299
Q+ +L N++ Q E LER+N+ L++K E++ +++ +S + +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 300 AILDILEHDRKEALEDRQ----ELVNRIYNLQEEARQAEELR---DKYLEEKEDLELKCS 352
A + LE ++ ++Q L + L+E Q E+ R ++Y E+ E +
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 353 TLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRD 387
L + E + + +++RE D+A S +
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Score = 54.3 bits (129), Expect = 7e-07
Identities = 67/364 (18%), Positives = 153/364 (42%), Gaps = 39/364 (10%)
Query: 119 VVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC---ELLARLRQLEDEKKQMTLTRVEL-- 173
++EE LT L E K + K K+ EL RL++ E ++++ + +L
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 174 --LTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ 231
F E+ ++ + +L K +++ R +KN A+ + R+L+ I
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 232 LKHRLNKMEEECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTKNQELQSI 286
L+ L+ + RN++ K K D+ + + E L+ + L+ K ++ ++
Sbjct: 1130 LQEDLDSE----RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 287 IQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKED 346
+ K++L + ++ ++ R++ + +EL ++ + ++ + +E D
Sbjct: 1186 L---KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 347 LELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ 406
L + LG+ + +H+ + Q++E++ + +R E + + E +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 407 IRELEEK-----------------NDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ E E K E+ E R++ +N+ +KLR+L ++ N+L L
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQL 1359
Query: 450 PRNL 453
+
Sbjct: 1360 DEEM 1363
Score = 47.0 bits (110), Expect = 1e-04
Identities = 74/386 (19%), Positives = 161/386 (41%), Gaps = 76/386 (19%)
Query: 135 VIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTR----VELLTFQERYYKMKEERDSY 190
V +L++ +A + Q E+ +L +LEDE + + V + + ++ + + RD
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS----------RDLQLEIDQ-LKHRLNKM 239
N+E K + L +L +E+ + + +DL+L+ D +K R +
Sbjct: 1594 NEE--KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 240 EEECKLERNQSLKLKNDIEN-RPKKEQVLELERENEM----LKTKNQELQSIIQAGKRSL 294
++ KL+ Q + ++E+ R ++++ +ENE L+ +LQ + A +R+
Sbjct: 1652 KQLRKLQA-QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 295 PDSDKAILDILEH-----DRKEALED-RQELVNRIYNLQEE------------------A 330
+D ++ E + AL+D ++ L RI L+EE
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 331 RQAEELRDKYLEEK------EDLELKCSTLGKDCEMYKHRMNTVML-------------- 370
+QAE+L ++ E+ E + K+ H M +
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 371 -----QLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE--MRIEMVR 423
Q+E+ RE+ A S + + + L++ + RK + +E+ ++ R++ ++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R+ + E + +R++ + L + L
Sbjct: 1891 RQ--LEEAEEESQRINANRRKLQREL 1914
Score = 32.7 bits (73), Expect = 2.0
Identities = 31/128 (24%), Positives = 60/128 (46%), Gaps = 19/128 (14%)
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
L A++ QLE++ +Q E Q +K++ + L++V+D+ +A +Y +
Sbjct: 1826 LEAKIAQLEEQVEQ------EAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQ 1878
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELER 271
+E+ N V QLK +L + EEE + KL+ +++ + + + R
Sbjct: 1879 AEKGNARVK----------QLKRQLEEAEEESQRINANRRKLQRELDEATESNEA--MGR 1926
Query: 272 ENEMLKTK 279
E LK+K
Sbjct: 1927 EVNALKSK 1934
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 1e-10
Identities = 72/340 (21%), Positives = 142/340 (41%), Gaps = 30/340 (8%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L + LQ+ + ++ R + + R L +E + + + L +++ +R+
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 191 NDELVKVKDDN--------YNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEE 242
L K D+ + ++AQ EE + + + + +D+ K L K +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 243 CKLERNQSLKLKNDIENRPKK--EQVLEL-------ERENEMLKTKNQELQSIIQA---- 289
E + K ++E++ KK QV EL ER L K +LQ+ +++
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 290 -----GKRSLPDSDKAILDILEHDRKEALED--RQEL--VNRIYNLQEEARQAEELRDKY 340
GK D A L D +E L++ RQ+L ++ L+EE ++ D+
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 341 LEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
+E K++LE STL K ++ +E +E + + + QY +
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSK 440
DK K L+++ D++ +++ + + NLE K R+ +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 64.7 bits (156), Expect = 5e-10
Identities = 80/361 (22%), Positives = 159/361 (44%), Gaps = 37/361 (10%)
Query: 137 KLQQQMKA-KDLQR-CELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKE-ERDSYNDE 193
K QQQ+ A K +QR C +LR + + + + +T QE + KE E +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 194 LVKVKDDNYNLAMRYAQLSEEKNM---AVMRSRDLQLEIDQLKHRL----NKMEE----- 241
K +++ L +++QL+EEKN+ + +L E ++++ RL ++EE
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 242 ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAI 301
E +LE + + E + +Q+L+LE + E + Q+LQ + + + I
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 302 LDILEHDRKEALEDRQELVNRIYNL-------QEEARQAEELRDKY------------LE 342
L +++ + ++R+ L RI +L +E+A+ +L++K+ E
Sbjct: 988 L-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046
Query: 343 EK--EDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEK 400
EK ++LE L D + ++ + Q+ E++ + + A + + +K
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 401 DKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460
+ K+IRELE +++ ++ A E + R L ++ L L L T Q
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 461 D 461
+
Sbjct: 1167 E 1167
Score = 55.1 bits (131), Expect = 4e-07
Identities = 90/386 (23%), Positives = 167/386 (43%), Gaps = 52/386 (13%)
Query: 104 KLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEK 163
+L K+ + F++ VE EG F E+ L QQ + K +L +L+ E
Sbjct: 1372 QLSDSKKKLQDFAS-TVEALEEGKKRF-QKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 164 KQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKD------DNYNLAMRYAQLSEEKNM 217
+ V+L ++ +++++ ++ L + K+ D + A A+ E K +
Sbjct: 1430 DDLV---VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 218 AVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE--LERENEM 275
++ R+ + LE + R NKM K E + K+D+ + + + LE + E
Sbjct: 1487 SLARALEEALEAKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 276 LKTKNQELQSIIQA---GKRSLPDSDKAILDILEHD---RKEALEDRQELVNRIYN---- 325
+KT+ +EL+ +QA K L + +A+ E D R E E+++ + R +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 326 -LQEEARQ---AEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQ 381
L++E +Q A + K + +DLEL+ + K E ++ + Q+++ +RE +
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 382 AFHSRDEA-----------------QTQYSQCLIEKDKYRKQI-RELEEKNDEMRIEMVR 423
A SRDE Q + L ++ RKQ E EE +E+ +
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R A L+ + RRL L++ L
Sbjct: 1724 RNA----LQDEKRRLEARIAQLEEEL 1745
Score = 55.1 bits (131), Expect = 4e-07
Identities = 60/275 (21%), Positives = 124/275 (45%), Gaps = 22/275 (8%)
Query: 132 MNEVIKLQQQMK--AKDLQ-----RCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMK 184
+ ++ KLQ QMK ++L+ R E+ A + E+EKK +L +L+ QE +
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAK--ENEKKAKSL-EADLMQLQEDLAAAE 1700
Query: 185 EERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECK 244
R + E ++ ++ + L +EK R L+ E+++ + + M + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 245 LERNQSLKLKNDIENRPKKEQVLE-----LERENEMLKTKNQELQSIIQAGKRSLPDSDK 299
Q+ +L N++ Q E LER+N+ L++K E++ +++ +S + +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 300 AILDILEHDRKEALEDRQ----ELVNRIYNLQEEARQAEELR---DKYLEEKEDLELKCS 352
A + LE ++ ++Q L + L+E Q E+ R ++Y E+ E +
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 353 TLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRD 387
L + E + + +++RE D+A S +
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Score = 54.3 bits (129), Expect = 7e-07
Identities = 67/364 (18%), Positives = 153/364 (42%), Gaps = 39/364 (10%)
Query: 119 VVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC---ELLARLRQLEDEKKQMTLTRVEL-- 173
++EE LT L E K + K K+ EL RL++ E ++++ + +L
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 174 --LTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ 231
F E+ ++ + +L K +++ R +KN A+ + R+L+ I
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 232 LKHRLNKMEEECKLERNQSLKLKNDIEN-----RPKKEQVLELERENEMLKTKNQELQSI 286
L+ L+ + RN++ K K D+ + + E L+ + L+ K ++ ++
Sbjct: 1123 LQEDLDSE----RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 287 IQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKED 346
+ K++L + ++ ++ R++ + +EL ++ + ++ + +E D
Sbjct: 1179 L---KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 347 LELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ 406
L + LG+ + +H+ + Q++E++ + +R E + + E +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 407 IRELEEK-----------------NDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ E E K E+ E R++ +N+ +KLR+L ++ N+L L
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVSTKLRQLEEERNSLQDQL 1352
Query: 450 PRNL 453
+
Sbjct: 1353 DEEM 1356
Score = 47.0 bits (110), Expect = 1e-04
Identities = 74/386 (19%), Positives = 161/386 (41%), Gaps = 76/386 (19%)
Query: 135 VIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTR----VELLTFQERYYKMKEERDSY 190
V +L++ +A + Q E+ +L +LEDE + + V + + ++ + + RD
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS----------RDLQLEIDQ-LKHRLNKM 239
N+E K + L +L +E+ + + +DL+L+ D +K R +
Sbjct: 1587 NEE--KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 240 EEECKLERNQSLKLKNDIEN-RPKKEQVLELERENEM----LKTKNQELQSIIQAGKRSL 294
++ KL+ Q + ++E+ R ++++ +ENE L+ +LQ + A +R+
Sbjct: 1645 KQLRKLQA-QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 295 PDSDKAILDILEH-----DRKEALED-RQELVNRIYNLQEE------------------A 330
+D ++ E + AL+D ++ L RI L+EE
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 331 RQAEELRDKYLEEK------EDLELKCSTLGKDCEMYKHRMNTVML-------------- 370
+QAE+L ++ E+ E + K+ H M +
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 371 -----QLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE--MRIEMVR 423
Q+E+ RE+ A S + + + L++ + RK + +E+ ++ R++ ++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 424 REACIVNLESKLRRLSKDSNNLDQSL 449
R+ + E + +R++ + L + L
Sbjct: 1884 RQ--LEEAEEESQRINANRRKLQREL 1907
Score = 32.7 bits (73), Expect = 2.0
Identities = 31/128 (24%), Positives = 60/128 (46%), Gaps = 19/128 (14%)
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
L A++ QLE++ +Q E Q +K++ + L++V+D+ +A +Y +
Sbjct: 1819 LEAKIAQLEEQVEQ------EAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQ 1871
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELER 271
+E+ N V QLK +L + EEE + KL+ +++ + + + R
Sbjct: 1872 AEKGNARVK----------QLKRQLEEAEEESQRINANRRKLQRELDEATESNEA--MGR 1919
Query: 272 ENEMLKTK 279
E LK+K
Sbjct: 1920 EVNALKSK 1927
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 66.6 bits (161), Expect = 1e-10
Identities = 79/339 (23%), Positives = 151/339 (44%), Gaps = 37/339 (10%)
Query: 141 QMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDD 200
Q + +++ E L R QL+ E + + + + ++ DE+ +K
Sbjct: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKA- 406
Query: 201 NYNLAMRYAQLSEE-KNMAVMRSRD--LQLEIDQLKHRLNKMEEEC-----KLER--NQS 250
N + EE K + V +S ++ +IDQLK L+K E E KLE NQ+
Sbjct: 407 --NGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQN 464
Query: 251 LKLKNDIEN-----RPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPD--SDKAILD 303
K IE K+++ L+ E + L+ + +E +S + + L D +K L
Sbjct: 465 SDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLA 524
Query: 304 ILEHDRKEALEDRQELVN----RIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCE 359
D K+ LE ++ +N +I NLQE+ R +DK L +D K +
Sbjct: 525 GEIRDMKDMLEVKERKINVLQKKIENLQEQLRD----KDKQLTNLKDRV-------KSLQ 573
Query: 360 MYKHRMNTVMLQLEEVERERDQAFHS-RDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMR 418
+T + LEE E+++ +++ + + L E + +RK+ ++L+EK + ++
Sbjct: 574 TDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQ 633
Query: 419 IEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTI 457
E+ +E+ +++L+ L+ D L ++L + I
Sbjct: 634 AELTEKESSLIDLKEHASSLASAGLKRDSKL-KSLEIAI 671
Score = 58.9 bits (141), Expect = 3e-08
Identities = 80/366 (21%), Positives = 165/366 (45%), Gaps = 55/366 (15%)
Query: 124 HEGLT---HFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVEL-LTFQER 179
H GLT H ++V + +Q++ D +L A+L++L+ E L R EL + +
Sbjct: 121 HGGLTGSSHHHHHQVPSMLRQVR--DSTMLDLQAQLKELQREND---LLRKELDIKDSKL 175
Query: 180 YYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKM 239
M + ++ EL K + A R + L E+ ++ ++ LQL I L
Sbjct: 176 GSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQAL------- 228
Query: 240 EEECKLERNQSLKLKNDIENRPKKEQVLELEREN---------------EMLKTKNQELQ 284
++E + +R+ + L+ + NR + +EL EN +L+ +E++
Sbjct: 229 QDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME 288
Query: 285 SIIQAGKRSLPDSDKAILDILEHDR-----KEALEDRQELVNRIYNLQEEARQAEELRDK 339
I+ K++L D++I +LE + ++LED E R+ + + E + D+
Sbjct: 289 LRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQ 348
Query: 340 YLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSR------DEAQTQY 393
+EKE++ L+ L + ++ T LQ ++ A R DE Q
Sbjct: 349 --KEKENIHLR-EELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLK 405
Query: 394 SQCLIEKDKYRKQIRELE----------EKNDEMRIEMVRREACIVNLESKLRRLSKDSN 443
+ ++ + ++I+++E K D+++ E+ ++E+ ++ L++KL LS ++
Sbjct: 406 ANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNS 465
Query: 444 NLDQSL 449
+ Q +
Sbjct: 466 DCKQHI 471
Score = 54.7 bits (130), Expect = 5e-07
Identities = 106/560 (18%), Positives = 217/560 (38%), Gaps = 100/560 (17%)
Query: 122 EGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDE----KKQMTLTRVELLTFQ 177
E ++ + F+ ++ +L+Q++ K+ + L +L L ++ K+ + + + L +
Sbjct: 423 EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKE 482
Query: 178 ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLN 237
+R ++ E D+ L + + + L+EEK RD++ ++ + ++N
Sbjct: 483 QRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKIN 542
Query: 238 KMEEECKLERNQSLKLKNDIENRPKKEQVLELERENE-------MLKTKNQELQSIIQAG 290
+++ K+E Q D + K++V L+ ++ L+ E + II+
Sbjct: 543 VLQK--KIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 291 KRSLPDSDKAILDILEHDRKEALEDRQELVNRIY-----------NLQEEARQAEELRDK 339
K D+ L+ +E RKE +D +E VN + +L+E A K
Sbjct: 601 KEQRERDDRERLEEIESFRKEN-KDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK 659
Query: 340 YLEEKEDLELKCSTLGKDCEMYK------------HRMNTVML-QLEEVERERDQAFHSR 386
+ + LE+ ++C + RMN Q++++++E A + R
Sbjct: 660 RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE---ASYYR 716
Query: 387 DEAQTQYSQCLIEKDKYRKQIRELE-EKNDEMRIEMVRREACIVNLESKLRRLSKDSNNL 445
DE + E D+ + ++E+E EKND ++ I LES R KD N
Sbjct: 717 DEC----GKAQAEVDRLLEILKEVENEKND--------KDKKIAELESLTLRHMKDQNKK 764
Query: 446 DQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGI 505
+L N + + N Q ++ E+S D+ L +
Sbjct: 765 VANLKHNQQL----------EKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQ 814
Query: 506 QLQRAKSPISLKRTSDFQAKGH------------------EEEGTDASPSSCGSLPITNS 547
+L K+ ++ + S + + H ++E A+ S +
Sbjct: 815 ELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLE 874
Query: 548 FTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHE 607
+ + +++ +M++ E D +V + K+ +R + DN DDD H
Sbjct: 875 LSASKKKKTQEEVMALKRE---KDRLVHQLKQQTQNRMKLMADN---------YDDDHHH 922
Query: 608 RYSFGPSSIHSSSSSHQSEG 627
+ H H+S G
Sbjct: 923 YHH------HHHHHHHRSPG 936
Score = 48.1 bits (113), Expect = 5e-05
Identities = 74/349 (21%), Positives = 150/349 (42%), Gaps = 30/349 (8%)
Query: 121 EEGHEGLTHFLMNEVIKLQQQMKAK-DLQRCELLARLRQLEDEKKQMTLTRVELLTFQER 179
E G+ G HF + + ++++A+ D Q EL + LE+ + ++ + L E
Sbjct: 245 ESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES 304
Query: 180 YYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEI---DQLKHRL 236
K+ E S ++DDN S+ ++ V+ + + I ++L R
Sbjct: 305 IKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRS 364
Query: 237 NKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPD 296
E K + Q++ D + + + +LE E +MLK G + D
Sbjct: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN----------GVLNTED 414
Query: 297 SDKAILDI---LEHDR--KEALED-RQELVNRIYNLQEEARQAEELRDKYLEEKEDLE-L 349
++ I I H + K ++ +QEL + L + E L ++ + K+ +E L
Sbjct: 415 REEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVL 474
Query: 350 KCSTLGKD--CEMYKHRMNTVMLQLEEVE----RERDQAFHSRDEAQTQYSQCLIEKDKY 403
K S K+ + + ++ + L+LEE E ++ Q +E T + KD
Sbjct: 475 KESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML 534
Query: 404 ---RKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
++I L++K + ++ ++ ++ + NL+ +++ L DS+N D +L
Sbjct: 535 EVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTAL 583
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 65.9 bits (159), Expect = 2e-10
Identities = 96/463 (20%), Positives = 200/463 (43%), Gaps = 87/463 (18%)
Query: 9 DDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPS 68
D Y+E L E DAL ++E R+ ++ K + ++++ + + LN L
Sbjct: 192 DRYIEELTKERDAL--SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKR 249
Query: 69 KINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLT 128
K+ RA LL + + ++ GKE
Sbjct: 250 KLERAKLLLPQQQLQAEADHL------------------GKE------------------ 273
Query: 129 HFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERD 188
L + KLQ Q++ EL RL Q ++EK ++ QE K++E+ +
Sbjct: 274 --LQSVSAKLQAQVEEN-----ELWNRLNQQQEEKMWRQEEKI-----QEWEEKIQEQEE 321
Query: 189 SYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKM--EEECKLE 246
++ K+++ + R ++ EK + R ++ E ++ RL +M E+E K+
Sbjct: 322 KIREQEEKIREQEEKMR-RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR 380
Query: 247 R-----NQSLKLKNDIENRPKKEQVLELERENEM------LKTKNQELQSIIQAGKRSLP 295
++ K++ E R ++E++ E E+ E + K +E + I+ ++ +
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 296 DSDKAILD---ILEHDRKEALED--RQELVNR----IYNLQEEARQAEELR--------- 337
++ I + I E ++++ E+ RQE R I+ +E+ + E++R
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 338 -DKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQC 396
+K +++E + + + + E + + + Q E++ RE+++ ++E + +
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKI-REQEEMMQEQEEKMGEQEEK 559
Query: 397 LIEKDKYRKQ---IRELEEKNDEMRIEMVRREACIVNLESKLR 436
+ E++K R+Q IRE EEK E + ++ +E I E K+R
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIR 602
Score = 63.5 bits (153), Expect = 1e-09
Identities = 63/267 (23%), Positives = 128/267 (47%), Gaps = 25/267 (9%)
Query: 178 ERYYK-MKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRL 236
+RY + + +ERD+ + EL + + L + A+L E+ + ++QL + +LK
Sbjct: 192 DRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK--- 248
Query: 237 NKMEEECKLERNQSLKLKNDIENRPKKEQVLELE---RENEMLKTKNQELQSIIQAGKRS 293
K+E L Q L+ + D + + +L+ ENE+ NQ+ + + +
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 294 LPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCST 353
+ + ++ I +++E + +++E +I +E+ R+ EE+ + EKE+ +
Sbjct: 309 IQEWEEKI-----QEQEEKIREQEE---KIREQEEKMRRQEEM----MWEKEEKMRRQEE 356
Query: 354 LGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEK 413
+ + E R+ +M + EE RE ++ H +++ + Q EK + ++IRE +EK
Sbjct: 357 MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE-----EKRQEEEKIRE-QEK 410
Query: 414 NDEMRIEMVRREACIVNLESKLRRLSK 440
E +M R+E I E K+R K
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEK 437
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/188 (18%), Positives = 93/188 (49%), Gaps = 10/188 (5%)
Query: 157 RQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKN 216
RQ E +Q + + E +++ KM ++ + ++ K+ + + ++ E++
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEE-KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537
Query: 217 MAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEML 276
+ +Q + +++ + KM+E+ K+ R + + + + R +KE++ E E +
Sbjct: 538 KIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ 597
Query: 277 KTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEEL 336
+ K +E + ++Q + + + ++ + +++E +++++E + R QEE +E+
Sbjct: 598 EEKIREQEEMMQEQEEKMWEQEEKMC-----EQEEKMQEQEEKMRR----QEEKMWEQEV 648
Query: 337 RDKYLEEK 344
R + EEK
Sbjct: 649 RLRQQEEK 656
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 65.5 bits (158), Expect = 3e-10
Identities = 61/269 (22%), Positives = 127/269 (47%), Gaps = 15/269 (5%)
Query: 178 ERYYK-MKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRL 236
+RY + + +ERD+ + EL + + L + A+L E+ + ++QL + +LK
Sbjct: 192 DRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK--- 248
Query: 237 NKMEEECKLERNQSLKLKNDIENRPKKEQVLELE---RENEMLKTKNQELQSIIQAGKRS 293
K+E L Q L+ + D + + +L+ ENE+ NQ+ + + +
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 294 LPDSDKAILDILE--HDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKC 351
+ + ++ I + E +++E + +++E + R + E + +++ + EKE+ +
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
Query: 352 STLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELE 411
+ + E R +M + EE RE ++ H +++ + Q EK + ++IRE +
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-----EKRQEEEKIRE-Q 422
Query: 412 EKNDEMRIEMVRREACIVNLESKLRRLSK 440
EK E +M R+E I E K+R K
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQEK 451
Score = 60.8 bits (146), Expect = 7e-09
Identities = 87/450 (19%), Positives = 193/450 (42%), Gaps = 74/450 (16%)
Query: 9 DDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPS 68
D Y+E L E DAL ++E R+ ++ K + ++++ + + LN L
Sbjct: 192 DRYIEELTKERDAL--SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKR 249
Query: 69 KINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLT 128
K+ RA LL + + ++ GKE
Sbjct: 250 KLERAKLLLPQQQLQAEADHL------------------GKE------------------ 273
Query: 129 HFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERD 188
L + KLQ Q++ EL RL Q ++EK ++ QE K++E+ +
Sbjct: 274 --LQSVSAKLQAQVEEN-----ELWNRLNQQQEEKMWRQEEKI-----QEWEEKIQEQEE 321
Query: 189 SYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKM--EEECKLE 246
++ K+++ + R ++ EK + R ++ E ++ R +M E+E K+
Sbjct: 322 KIREQEEKIREQEEKMR-RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 247 RNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILE 306
R + + + + + R +E++ E E+ E + K QE + I + KR ++ +
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQ-EEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 307 HDRKEALEDRQ-------ELVNRIYNLQEEARQAEE----LRDKYLEEKEDLELKCSTLG 355
+++E + +++ E ++ ++EE ++ E+ +++ + E+E++ + +
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 356 KDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIREL----- 410
+ E + + V Q E++ RE+++ ++E + + + E+++ ++ ++
Sbjct: 500 EQEEKIRKQEEKVWRQEEKI-REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 411 ---EEKNDEMRIEMVRREACIVNLESKLRR 437
EEK E +M R+E I E K+ R
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Score = 51.6 bits (122), Expect = 4e-06
Identities = 62/358 (17%), Positives = 156/358 (43%), Gaps = 50/358 (13%)
Query: 139 QQQMKAKDLQRCELLARLRQLED------------EKKQMTLTRVELLTFQERYYKMKEE 186
+++M+ ++ E ++R+LE+ EK+Q E QE+ KM +
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 435
Query: 187 RDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEE----- 241
+ ++ K+++ + + ++ E++ + R Q E+ + + ++++ EE
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 242 ------ECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLP 295
E K+ + + + + + R ++E++ E E + + K +E + + + ++ +
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK-MH 554
Query: 296 DSDKAILDILEHDRKEALEDR--------QELVNRIYNLQEEARQAEELR---------- 337
+ +K I E ++++ ED+ +E +++ +E+ R+ EE R
Sbjct: 555 EQEK----IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 338 -DKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQC 396
+K E++E ++ + + + E + + Q E++ + ++ ++ Q Q
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 397 LIEKDKYRKQ---IRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+++K R+Q IRE EEK E M +E + E K+ + ++ + R
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728
Score = 48.9 bits (115), Expect = 3e-05
Identities = 59/312 (18%), Positives = 143/312 (45%), Gaps = 21/312 (6%)
Query: 134 EVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVE-LLTFQERYYKMKEERDSYND 192
E I+ Q++ + ++ ++R+ E ++Q + R E + QE ++ KE+ +
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 193 ELVKVKDDNYNLAMRYAQLSE---EKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
++ K ++ + + + E E+ + R + E +++ KM E+ K+ +
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
+ + D R ++E++ E E + + K +E + Q + + ++ I ++
Sbjct: 564 KRQEQEDKMWR-QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI-----REQ 617
Query: 310 KEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVM 369
+E +++++E +I +E+ R+ EE+ + E+ + E K + E M
Sbjct: 618 EEKIQEQEE---KIREQEEKIREQEEMTQEQEEKMGEQEEKMC----EQEEKMQEQEETM 670
Query: 370 LQLEEVERERDQAFHSRDEAQTQYSQCLIEKD----KYRKQIRELEEKNDEMRIEMVRRE 425
+ EE RE+++ ++E + + + E++ + +++ E EEK E +M R+E
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 426 ACIVNLESKLRR 437
+ E +LR+
Sbjct: 731 EKMWEQEVRLRQ 742
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 65.1 bits (157), Expect = 4e-10
Identities = 87/369 (23%), Positives = 164/369 (44%), Gaps = 78/369 (21%)
Query: 132 MNEVIKLQQQMK--AKDLQ-----RCELLARLRQLEDEKKQMTLTRVEL---LTFQERYY 181
+ ++ KLQ QMK ++L R E+LA+ ++ E + K M ++L L ER
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 182 KM-KEERDSYNDELVKVK-------DDNYNLAMRYAQLSEE-------KNMAVMRSRDLQ 226
+ ++ERD DE+ ++ L R AQL EE + R +
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 227 LEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSI 286
L+IDQ+ LN LER+ + K +N + +LER+N+ LK K QE++
Sbjct: 1757 LQIDQINTDLN-------LERSHAQKNENARQ---------QLERQNKELKVKLQEMEGT 1800
Query: 287 IQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKED 346
+++ ++ + +A + LE ++RQ ++ R ++L+D L+ ++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV------RRTEKKLKDVLLQVDDE 1854
Query: 347 LELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQ 406
++ E YK + + +L++++R+ ++A +EAQ + + K +++
Sbjct: 1855 --------RRNAEQYKDQADKASTRLKQLKRQLEEA---EEEAQ----RANASRRKLQRE 1899
Query: 407 IRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDAS 466
+ + E D M E + +L++KLRR LP +P + + GD S
Sbjct: 1900 LEDATETADAMNRE-------VSSLKNKLRR---------GDLPFVVPRRMARKGAGDGS 1943
Query: 467 PRTNGQEAD 475
+AD
Sbjct: 1944 DEEVDGKAD 1952
Score = 60.8 bits (146), Expect = 7e-09
Identities = 65/320 (20%), Positives = 146/320 (45%), Gaps = 43/320 (13%)
Query: 135 VIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDEL 194
+ L+++++ ++ QR EL R+LE + ++ EL Q + ++K + L
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL---QAQIAELKMQ-------L 1078
Query: 195 VKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLK 254
K +++ R + + +KNMA+ + R+L+ +I +L+ L E + RN++ K K
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL----ESERASRNKAEKQK 1134
Query: 255 NDIEN-----RPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
D+ + + E L+ + L++K ++ +I+ K++L + K
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL---KKTLEEEAKT-------HE 1184
Query: 310 KEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVM 369
+ E RQ+ + L E+ Q + ++ + K+ LE + L + + V+
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK--------VL 1236
Query: 370 LQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIV 429
LQ + + H R + + Q + ++ ++ + EL +K ++++E+ +
Sbjct: 1237 LQ------GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 430 NLESKLRRLSKDSNNLDQSL 449
+SK +L+KD + L+ L
Sbjct: 1291 QSDSKSSKLTKDFSALESQL 1310
Score = 60.5 bits (145), Expect = 9e-09
Identities = 104/471 (22%), Positives = 197/471 (41%), Gaps = 61/471 (12%)
Query: 7 EMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPML 66
E + + E L++EE+A +H L + I A L + K E + A +
Sbjct: 1337 EKNSFREQLEEEEEA--------KHNLEKQI--ATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 67 PSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEG 126
K+ + L H + Y ++ EL L+ + R+ S +E+ +
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ-SACNLEKKQKK 1445
Query: 127 LTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRV--ELLTFQERYYKMK 184
L E K A++ R E AR E E K ++L R E + + ++
Sbjct: 1446 FDQLLAEE--KTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKAELERLN 1499
Query: 185 EERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEE-EC 243
++ + ++L+ KDD + +L + K + +++ ++++L+ L E+ +
Sbjct: 1500 KQFRTEMEDLMSSKDD---VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 244 KLERN-QSLKLK-------NDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLP 295
+LE N Q++K + D ++ KK+Q++ RE E ++ +S+ A ++ L
Sbjct: 1557 RLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE 1616
Query: 296 DSDK---AILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCS 352
K A +D +R EA++ ++L ++ + E R++ L + ++ E K
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 353 TLGKDCEMYKHRMNTVMLQLEE----VERERDQAFHSRDEAQTQYSQ-------CLIEKD 401
+ M M+QL+E ER + QA RDE + + L EK
Sbjct: 1677 S-----------MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 402 KYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRN 452
+ +I +LEE+ +E E E ++N K L D N D +L R+
Sbjct: 1726 RLEARIAQLEEELEE---EQGNTE--LINDRLKKANLQIDQINTDLNLERS 1771
Score = 57.0 bits (136), Expect = 1e-07
Identities = 82/359 (22%), Positives = 150/359 (41%), Gaps = 49/359 (13%)
Query: 125 EGLTHFLMNEVIKLQQQMKAKDLQRC----ELLARLRQLEDE--KKQMTLTRVELLTFQ- 177
EG + L +++ +LQ Q+ +Q EL A L ++E+E +K M L ++ L Q
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 178 -ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRL 236
E ++ ER S N + +D L +L + + + ++L+ + +Q + L
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSKREQEVNIL 1172
Query: 237 NK-MEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLP 295
K +EEE K Q +++ ++ E++ E + + +K ++ + ++ + L
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQ--KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230
Query: 296 DSDKAILD---ILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLE---- 348
+ K +L EH RK+ QEL + E R EL DK + + +L+
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKF---NEGERVRTELADKVTKLQVELDNVTG 1287
Query: 349 ------LKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDK 402
K S L KD + ++ L+E R++ T+ Q EK+
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL-------STKLKQVEDEKNS 1340
Query: 403 YRKQIRELEEKND--------------EMRIEMVRREACIVNLESKLRRLSKDSNNLDQ 447
+R+Q+ E EE +M+ +M C+ E R+L KD L Q
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Score = 55.5 bits (132), Expect = 3e-07
Identities = 75/342 (21%), Positives = 145/342 (42%), Gaps = 34/342 (9%)
Query: 134 EVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMK-EERDSYND 192
+V + +++M AK+ + ++ R +QL E + LT +E L Q K++ +E+
Sbjct: 839 QVSRQEEEMMAKEEELVKV--REKQLAAENR---LTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 193 ELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLK 252
EL ++ A+L+ +K DL+ +++ + R ++ E K + +
Sbjct: 894 ELCAEAEE------LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 253 LKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILD--------- 303
L+ +E Q L+LE+ K K E + II + +K +L+
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 304 ILEHDRKEA----LEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCE 359
+ E + K L+++ E + I +L+E R+ E+ R + + + LE + L
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAM--ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 360 MYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRI 419
+ ++ + +QL + E E A +E Q + L + + QI EL+E + R
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 420 EMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQD 461
R +A E + R L ++ L L L T Q+
Sbjct: 1126 S--RNKA-----EKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/222 (19%), Positives = 96/222 (43%), Gaps = 40/222 (18%)
Query: 262 KKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVN 321
K + +L++ R+ E + K +EL ++ ++ L ++ L +E + + + ++ +L
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEEL---VKVREKQLAAENR--LTEMETLQSQLMAEKLQLQE 887
Query: 322 RIYNLQEEARQAEELRDKYLEEKEDLELKCSTL-------GKDCEMYKHRMNTVMLQLEE 374
++ E +AEELR + +K++LE C L + C+ + + ++E
Sbjct: 888 QLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 375 VERERDQAFHSRDEAQTQY-------------------SQCLIEKDK---------YRKQ 406
+E + ++ +R + Q + C + K+K +
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 407 IRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQS 448
+ E EEK+ + + EA I +LE +LRR K L+++
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT 1049
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 65.1 bits (157), Expect = 4e-10
Identities = 100/517 (19%), Positives = 217/517 (41%), Gaps = 51/517 (9%)
Query: 49 CKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTG 108
C ++ EQ E+E L +++A + TK + + E LE +L + +
Sbjct: 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400
Query: 109 KEP------TRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC---ELLARLR-Q 158
E + S ++ +G LM +V + A D ++ ++LA + +
Sbjct: 1401 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460
Query: 159 LEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEE---- 214
E+ + ++ + E + +K+K + D+L VK +N NL A L+E+
Sbjct: 1461 CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520
Query: 215 -KNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQ----VLEL 269
K + + Q+E+++ +L E E LE ++ L+ +E K + + E
Sbjct: 1521 GKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 270 ERENEMLKTKNQE----LQSIIQAGKRS------LPDSDKAILDILEHDRKEALEDRQEL 319
+ E E LK Q +QS + A RS L + L+ +E A E
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640
Query: 320 VNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERER 379
+ + ++Q + + + D L +EDL+ + + + + + + + + LE+ ER R
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 380 DQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLS 439
A Q L++ + ++++ L +N + + E ++ L+S++ S
Sbjct: 1701 KLA-----------EQELLDSN---ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 440 KDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRR 499
+D+ N ++ + + + + T+ E++ +D ++ L +
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL---DEAEQ 1803
Query: 500 MNLKG--IQLQRAKSPISLKRTSDFQAKGHEEEGTDA 534
+ LKG Q+Q+ ++ I R +F+ +G +++ T++
Sbjct: 1804 LALKGGKKQIQKLETRI---RELEFELEGEQKKNTES 1837
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/351 (21%), Positives = 149/351 (42%), Gaps = 33/351 (9%)
Query: 120 VEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKK-QMTLTRV------E 172
++E H+ L E K+ K K ++ LE EKK ++ L R +
Sbjct: 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD 1059
Query: 173 LLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQL 232
L QE ++ ++ DE +K KD Y +++ +E+ + + Q +I +L
Sbjct: 1060 LKLAQESILDLENDKQQL-DERLKKKDFEY--CQLQSKVEDEQTLGLQ----FQKKIKEL 1112
Query: 233 KHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKR 292
+ R+ ++EEE + ER K + + + + ELE +E L+ + I+ K+
Sbjct: 1113 QARIEELEEEIEAERATRAKTE-----KQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167
Query: 293 SLPDSDKAILDI----LEHD------RKEALEDRQELVNRIYNLQEEARQAEELRDKYLE 342
+ K D+ L+H+ RK+ + EL +I NLQ ++ E+ + ++
Sbjct: 1168 REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1227
Query: 343 EKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDK 402
E +DL ++ K + T+ QL E + ++ S E TQ S+ E +
Sbjct: 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE 1287
Query: 403 YRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNL 453
+Q+ E+ + + ++ R + +L+R ++ N +L L
Sbjct: 1288 LSRQL----EEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHAL 1334
Score = 57.4 bits (137), Expect = 8e-08
Identities = 65/284 (22%), Positives = 120/284 (42%), Gaps = 30/284 (10%)
Query: 183 MKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEE 242
MKEE DEL K + L + L +EKN DLQL++ L EE
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKN-------DLQLQVQAESENLLDAEER 905
Query: 243 CKLERNQSLKLKNDIENRPKK--EQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA 300
C +Q +K K +E + K+ E+ + E N L K ++L+ K+ + D +
Sbjct: 906 C----DQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 301 ILDI------LEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTL 354
+ + E+ K E+ L I L E + +E + L++ + E K ++L
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSL 1021
Query: 355 GKDCEMYKHRMNTVMLQLEE-----VERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRE 409
K + ++ + LE+ V+ ER++ D Q S +E DK +Q+ E
Sbjct: 1022 NKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK--QQLDE 1079
Query: 410 LEEKND----EMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+K D +++ ++ + + + K++ L L++ +
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI 1123
Score = 57.4 bits (137), Expect = 8e-08
Identities = 63/289 (21%), Positives = 141/289 (48%), Gaps = 31/289 (10%)
Query: 136 IKLQQQMKAKDL----QRCELLARLR-QLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
++LQ Q ++++L +RC+ L + + QLE + K++T R E +E ++ ++
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT-ERAE--DEEEINAELTAKKRKL 944
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQS 250
DE ++K D +L + A++ +EK+ + ++L E+ L + K+ E K +
Sbjct: 945 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Query: 251 LKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRK 310
+ +D++ ++++V L + L+ + ++L+S ++ K+ D LE +++
Sbjct: 1005 QQALDDLQ--AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD--------LERNKR 1054
Query: 311 EALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKC---STLGKDCEMYKHRMNT 367
+ D + I +L+ + +Q +E K E L+ K TLG ++ ++
Sbjct: 1055 KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGL---QFQKKIKE 1111
Query: 368 VMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE 416
+ ++EE+E E + +R + + Q S Y +++ EL E+ +E
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSD-------YARELEELSERLEE 1153
Score = 55.5 bits (132), Expect = 3e-07
Identities = 73/374 (19%), Positives = 167/374 (44%), Gaps = 62/374 (16%)
Query: 137 KLQQQMKAKDLQRCELLARLRQ----LEDEKKQMTLTRVELLTFQERYYKMKEERDSYND 192
+L++ K +L++ ++ L + LE E+ ++ ++EL + + E+D +
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585
Query: 193 ELVKVKDDNYNLAMRYAQLS-----EEKNMAVMRSRDLQLEID----QLKHRLNKMEEEC 243
+L + NY + Q + +N A+ + ++ +++ QL H + E
Sbjct: 1586 QLKR----NYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL 1641
Query: 244 KLERNQSLKLKN-----DIENRPK---KEQVLELERENEMLKTKNQELQSIIQAGKRSLP 295
K R+ +LK+ D R + KEQ+ +ER +L+ + +EL++ ++ +R+
Sbjct: 1642 KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARK 1701
Query: 296 DSDKAILDILE-------------HDRKEALEDRQELVNRIYNLQEEARQAEELRDKY-- 340
+++ +LD E H +K+ D +L + + + +AR AEE K
Sbjct: 1702 LAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAIT 1761
Query: 341 --------LEEKEDLELKCSTLGKDCEM----YKHRMNTV--------MLQLEEVE-RER 379
L++++D + K+ E +HR++ Q++++E R R
Sbjct: 1762 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIR 1821
Query: 380 DQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLS 439
+ F E Q + ++ + KY ++++EL +++E R ++R + + L+ K++
Sbjct: 1822 ELEFELEGE-QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYK 1880
Query: 440 KDSNNLDQSLPRNL 453
+ + D+ +L
Sbjct: 1881 RQAEEADEQANAHL 1894
Score = 54.3 bits (129), Expect = 7e-07
Identities = 82/411 (19%), Positives = 170/411 (41%), Gaps = 42/411 (10%)
Query: 40 AKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYY 99
AKLT R+ K + E + + + K+N + L + +E LE
Sbjct: 991 AKLT---REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ--------VEDLESSL 1039
Query: 100 PELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQL 159
+ KL E +R ++ E + L N+ +L +++K KD + C+L +++
Sbjct: 1040 EQEKKLRVDLERNKRKLEGDLKLAQESILD-LENDKQQLDERLKKKDFEYCQLQSKV--- 1095
Query: 160 EDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAV 219
EDE+ + ++ Q R +++EE ++ K + + A +LSE A
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Query: 220 MRSRDLQLEIDQLKH----RLNKMEEECKLERNQSL------------KLKNDIENRPKK 263
+ Q+E+++ + +L + EE L+ + +L I+N +
Sbjct: 1156 GVT-STQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRV 1214
Query: 264 EQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRI 323
+Q +LE+E K + +L S +++ +S + +K I LE EA +E+ +
Sbjct: 1215 KQ--KLEKEKSEFKLEIDDLSSSMESVSKSKANLEK-ICRTLEDQLSEARGKNEEIQRSL 1271
Query: 324 YNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAF 383
L + + + + + E+ E S L + + + + + QLEE + ++
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Query: 384 HSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESK 434
H+ Q+ C D R+Q E +E E++ + + + + +K
Sbjct: 1332 HA---LQSSRHDC----DLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1375
Score = 45.1 bits (105), Expect = 4e-04
Identities = 59/298 (19%), Positives = 128/298 (42%), Gaps = 28/298 (9%)
Query: 152 LLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL 211
LL L ++ D++ +TR + + R + M+ E ++V+ ++ + +
Sbjct: 770 LLGTLEEMRDDRLAKLITRTQAVC---RGFLMRVEFQ----KMVQRRESIFCIQYNIRSF 822
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELER 271
K+ M+ L +I L + + E+E + + K K+++ K + ELE
Sbjct: 823 MNVKHWPWMK---LFFKIKPLL-KSAETEKEMATMKEEFQKTKDELAKSEAKRK--ELEE 876
Query: 272 ENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEAR 331
+ L + +LQ +QA +L D+++ + ++ + +L +I + E A
Sbjct: 877 KLVTLVQEKNDLQLQVQAESENLLDAEERC--------DQLIKAKFQLEAKIKEVTERAE 928
Query: 332 QAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQT 391
EE+ + +K LE +CS L KD ++ + L L +VE+E+ +
Sbjct: 929 DEEEINAELTAKKRKLEDECSELKKD-------IDDLELTLAKVEKEKHATENKVKNLTE 981
Query: 392 QYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
+ S K ++ + L+E + + ++ E + +L +L + +L+ SL
Sbjct: 982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL 1039
Score = 37.7 bits (86), Expect = 0.064
Identities = 26/155 (16%), Positives = 77/155 (49%), Gaps = 2/155 (1%)
Query: 299 KAILDILEHDRKEAL--EDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGK 356
K +L E +++ A E+ Q+ + + + + ++ EE ++EK DL+L+ +
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE 897
Query: 357 DCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDE 416
+ + R + ++ ++E + + ++ + ++ +K K + EL++ D+
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 417 MRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPR 451
+ + + + E E+K++ L+++ + LD+++ +
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAK 992
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 65.1 bits (157), Expect = 4e-10
Identities = 73/342 (21%), Positives = 142/342 (41%), Gaps = 48/342 (14%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L +E + L+ +MK L+ ++ E + K + E T Q + K +E
Sbjct: 411 LESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV---EEKSTIQSKLSKTEEYSKEC 467
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLE-IDQLKHRLNKMEEECKLERNQ 249
E K+ YN+ + EEKN+ + + +E +DQLK + +K + + + N+
Sbjct: 468 LKEFKKIIS-KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 526
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
+ ++ IE K +L ++ E EML+ K +L + L +S I+ + E +R
Sbjct: 527 NNRMS--IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER 584
Query: 310 ---------------------------KEALEDRQELVNRIYNLQEEARQAEELRDKYLE 342
+E+ RQ + I N+Q AEE +L+
Sbjct: 585 LAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE---NFLQ 641
Query: 343 EKEDLELKCST-------LGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQ 395
E ++ + + S +GK+CEM + + ++ E + HS++ + + S
Sbjct: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKK--HSQENIKFENSI 699
Query: 396 CLIEKDK--YRKQIRELEEKNDEMRIEMVRREACIVNLESKL 435
+ +DK +R +E + D + EM + ++L K+
Sbjct: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
Score = 53.9 bits (128), Expect = 9e-07
Identities = 67/315 (21%), Positives = 133/315 (42%), Gaps = 26/315 (8%)
Query: 92 LESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHF--LMNEVIKLQQQMKAKDLQR 149
++ +E Y +L LV K + + E E L F ++++ LQ Q K + +
Sbjct: 433 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 492
Query: 150 CELLARLRQ----LEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLA 205
+L +Q L+ K + T+ ++ +M E ++ ++ ++D+ L
Sbjct: 493 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 552
Query: 206 MRYAQLSEEKNMAVMRSRDLQLEIDQL--KHRLNKMEEECKLE-----RNQSLKLKNDIE 258
+ QL +EK+ ++ QLEI QL K RL K E+E L+ +++ L L+ ++
Sbjct: 553 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 612
Query: 259 NRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQE 318
Q++E E EN E ++ +Q K + K+ I ++ E ++ +
Sbjct: 613 ESTAARQIMEREIENIQTYQSTAE-ENFLQEIKNA-----KSEASIYKNSLSEIGKECEM 666
Query: 319 LVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERE 378
L + + + + +E K+ +E E S L +D + ++ + +E E
Sbjct: 667 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN-------YVRSIENE 719
Query: 379 RDQAFHSRDEAQTQY 393
RD Q +Y
Sbjct: 720 RDTLEFEMRHLQREY 734
Score = 41.6 bits (96), Expect = 0.004
Identities = 53/229 (23%), Positives = 103/229 (44%), Gaps = 28/229 (12%)
Query: 235 RLNKMEEEC--KLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQEL----QSIIQ 288
++N + E+C K++ Q+ LK ++ + K V+ELE EN LK+K + L QS+IQ
Sbjct: 379 KVNSVTEQCVAKIQYLQNY-LKESVQIQKK---VMELESENLNLKSKMKPLIFTTQSLIQ 434
Query: 289 AGK------RSLPDSDKAI---LDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDK 339
+ ++L + I L E KE L++ ++++++ LQ + +K
Sbjct: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQ--------NK 486
Query: 340 YLEEKE-DLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLI 398
LEEK L L+ + + + K + + + V E ++ + +T
Sbjct: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
Query: 399 EKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQ 447
EK+ K+ +L ++ + E+ + I+ L+ K R + L Q
Sbjct: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQ 595
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 65.1 bits (157), Expect = 4e-10
Identities = 73/342 (21%), Positives = 142/342 (41%), Gaps = 48/342 (14%)
Query: 131 LMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSY 190
L +E + L+ +MK L+ ++ E + K + E T Q + K +E
Sbjct: 448 LESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV---EEKSTIQSKLSKTEEYSKEC 504
Query: 191 NDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLE-IDQLKHRLNKMEEECKLERNQ 249
E K+ YN+ + EEKN+ + + +E +DQLK + +K + + + N+
Sbjct: 505 LKEFKKIIS-KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 563
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
+ ++ IE K +L ++ E EML+ K +L + L +S I+ + E +R
Sbjct: 564 NNRMS--IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER 621
Query: 310 ---------------------------KEALEDRQELVNRIYNLQEEARQAEELRDKYLE 342
+E+ RQ + I N+Q AEE +L+
Sbjct: 622 LAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE---NFLQ 678
Query: 343 EKEDLELKCST-------LGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQ 395
E ++ + + S +GK+CEM + + ++ E + HS++ + + S
Sbjct: 679 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKK--HSQENIKFENSI 736
Query: 396 CLIEKDK--YRKQIRELEEKNDEMRIEMVRREACIVNLESKL 435
+ +DK +R +E + D + EM + ++L K+
Sbjct: 737 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 778
Score = 53.9 bits (128), Expect = 9e-07
Identities = 67/315 (21%), Positives = 133/315 (42%), Gaps = 26/315 (8%)
Query: 92 LESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHF--LMNEVIKLQQQMKAKDLQR 149
++ +E Y +L LV K + + E E L F ++++ LQ Q K + +
Sbjct: 470 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 529
Query: 150 CELLARLRQ----LEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLA 205
+L +Q L+ K + T+ ++ +M E ++ ++ ++D+ L
Sbjct: 530 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 589
Query: 206 MRYAQLSEEKNMAVMRSRDLQLEIDQL--KHRLNKMEEECKLE-----RNQSLKLKNDIE 258
+ QL +EK+ ++ QLEI QL K RL K E+E L+ +++ L L+ ++
Sbjct: 590 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 649
Query: 259 NRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQE 318
Q++E E EN E ++ +Q K + K+ I ++ E ++ +
Sbjct: 650 ESTAARQIMEREIENIQTYQSTAE-ENFLQEIKNA-----KSEASIYKNSLSEIGKECEM 703
Query: 319 LVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERE 378
L + + + + +E K+ +E E S L +D + ++ + +E E
Sbjct: 704 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN-------YVRSIENE 756
Query: 379 RDQAFHSRDEAQTQY 393
RD Q +Y
Sbjct: 757 RDTLEFEMRHLQREY 771
Score = 41.6 bits (96), Expect = 0.004
Identities = 53/229 (23%), Positives = 103/229 (44%), Gaps = 28/229 (12%)
Query: 235 RLNKMEEEC--KLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQEL----QSIIQ 288
++N + E+C K++ Q+ LK ++ + K V+ELE EN LK+K + L QS+IQ
Sbjct: 416 KVNSVTEQCVAKIQYLQNY-LKESVQIQKK---VMELESENLNLKSKMKPLIFTTQSLIQ 471
Query: 289 AGK------RSLPDSDKAI---LDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDK 339
+ ++L + I L E KE L++ ++++++ LQ + +K
Sbjct: 472 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQ--------NK 523
Query: 340 YLEEKE-DLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLI 398
LEEK L L+ + + + K + + + V E ++ + +T
Sbjct: 524 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 583
Query: 399 EKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQ 447
EK+ K+ +L ++ + E+ + I+ L+ K R + L Q
Sbjct: 584 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQ 632
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/348 (25%), Positives = 154/348 (44%), Gaps = 59/348 (16%)
Query: 158 QLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAM------RYAQL 211
+L D K ++ R EL E+ + E D EL KVK +N LA Y
Sbjct: 255 ELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDE 314
Query: 212 SEEKNMAVMRSRDLQLEIDQLKHRLNKME------EECKLERNQSLKLKNDIEN-----R 260
+ R L+LE+ + K +L+ ++ EE + + ++ K +E R
Sbjct: 315 LDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAAR 374
Query: 261 PKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPD--SDKAILDI-------------- 304
+ ++V ELE+EN LK+K +L+ K+ + + + +L+I
Sbjct: 375 ARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGW 434
Query: 305 -LEHDRKEA-LED--RQELV--------NRIYNLQEEARQAEE----LRDKYLEEKEDLE 348
LE K A L D R+ V +RI L++E + + LRD L E+
Sbjct: 435 ELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL-VLEESG 493
Query: 349 LKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHS------RDEAQTQYSQCLIEKDK 402
LKC L K+ ++ + QLE E++ +Q + R++ Q Q ++ DK
Sbjct: 494 LKCGELEKENHQLSKKIEKLQTQLER-EKQSNQDLETLSEELIREKEQLQSDMETLKADK 552
Query: 403 YRKQIRELEEKNDEM-RIEMVRREACIVNLESKLRRLSKDSNNLDQSL 449
R QI++LE++ D + R RE V+ E++++ + K++ L Q++
Sbjct: 553 AR-QIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTV 599
Score = 62.4 bits (150), Expect = 2e-09
Identities = 82/366 (22%), Positives = 160/366 (43%), Gaps = 62/366 (16%)
Query: 110 EPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQR---------CELLARLRQLE 160
+ R+ + E+ H + + E ++ + + KD+++ E +L QLE
Sbjct: 551 DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLE 610
Query: 161 DEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQL---SEEKNM 217
EK+Q+ + ER K++ E L +++++N LA + L +E+
Sbjct: 611 FEKRQLHRDLEQAKEKGERAEKLERE-------LQRLQEENGRLARKVTSLETATEKVEA 663
Query: 218 AVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLK 277
S+ LQLE L+ L+ ++ N SL+L+ LER+N+ L
Sbjct: 664 LEHESQGLQLENRTLRKSLDTLQ-------NVSLQLEG-------------LERDNKQLD 703
Query: 278 TKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELR 337
+N EL+ +++ + + L +E + ++ +++EL + L+ +++E L
Sbjct: 704 AENLELRRLVETMRFT-----STKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLE 758
Query: 338 DKYLE-EKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQC 396
Y E+L L+ S E H+ T+ +L E+E ER QA EA +
Sbjct: 759 LSYQSVSAENLRLQQSL-----ESSSHKTQTLESELGELEAER-QALRRDLEALRLANAQ 812
Query: 397 LIEKDKYRKQIRE-----------LEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNL 445
L +K RK + + LE++ + ++ ++A + + +KL + K+S L
Sbjct: 813 LEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872
Query: 446 DQSLPR 451
D+ L R
Sbjct: 873 DKELAR 878
Score = 56.6 bits (135), Expect = 1e-07
Identities = 77/372 (20%), Positives = 156/372 (41%), Gaps = 45/372 (12%)
Query: 114 RFSTIVVEEGH------EGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMT 167
R +++V+EE E H L ++ KLQ Q++ + +L +L EK+Q+
Sbjct: 483 RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQ 542
Query: 168 LTRVELLTFQERYYK-MKEERDSYNDEL------------VKVKD---DNYNLAMRYAQL 211
L + R K +++E+D N + ++KD +N L +
Sbjct: 543 SDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEA 602
Query: 212 SEEKNMAVMRSRDLQLEIDQLK---HRLNKMEEECKLERNQSLKLKNDIEN-RPKKEQVL 267
+ + + R L +++Q K R K+E E + + ++ +L + + E+V
Sbjct: 603 NGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVE 662
Query: 268 ELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDI--LEHDRKEALEDRQELVNRIYN 325
LE E++ L+ +N+ L ++SL L + LE D K+ + EL +
Sbjct: 663 ALEHESQGLQLENRTL-------RKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVET 715
Query: 326 LQ-EEARQAEELRDKYLEEKEDLELK-----CSTLGKDCEMYKHRMNTVMLQLEEVERER 379
++ + A+ R+ E+E EL+ LGK E + +V + +++
Sbjct: 716 MRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSL 775
Query: 380 DQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLS 439
+ + H +++ + E+ R+ + L N ++ R+A LE ++ +L
Sbjct: 776 ESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA----LEQEVAQLE 831
Query: 440 KDSNNLDQSLPR 451
KD L++ R
Sbjct: 832 KDKKLLEKEAKR 843
Score = 53.1 bits (126), Expect = 1e-06
Identities = 69/306 (22%), Positives = 144/306 (47%), Gaps = 43/306 (14%)
Query: 155 RLRQLEDEKKQMTLTRVELL----TFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQ 210
++ +LE E Q+ +L T ++R ++ EE + +++ +L Q
Sbjct: 379 KVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQ 438
Query: 211 LSEEKNMAVMRSRDLQLEIDQL-KHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLE- 268
LS+ +++ + E+++ R+ K+E+E NQSL+ + I+ VLE
Sbjct: 439 LSKNADLSDASRKSFVFELNECASSRILKLEKE-----NQSLQ--STIQGLRDASLVLEE 491
Query: 269 -------LERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVN 321
LE+EN L K ++LQ+ ++ K+S D LE +E + ++++L +
Sbjct: 492 SGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQD--------LETLSEELIREKEQLQS 543
Query: 322 RIYNLQ-EEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERD 380
+ L+ ++ARQ ++L +EK+ L +L + ++ ++++VE+E
Sbjct: 544 DMETLKADKARQIKDLE----QEKDHLNRAMWSLRERSQVSSE------ARMKDVEKENK 593
Query: 381 QAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSK 440
+ EA + SQ EK + + + + +EK + R E + RE + L+ + RL++
Sbjct: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGE--RAEKLERE--LQRLQEENGRLAR 649
Query: 441 DSNNLD 446
+L+
Sbjct: 650 KVTSLE 655
Score = 48.5 bits (114), Expect = 4e-05
Identities = 132/694 (19%), Positives = 261/694 (37%), Gaps = 88/694 (12%)
Query: 8 MDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLP 67
+D + +D L E + NR + + A+ LR+ V+++ L + L
Sbjct: 872 LDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEK------LKSQQLS 925
Query: 68 SKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGL 127
S++++ + L+ + + + L+ + YK++ G+ + +T+ ++E L
Sbjct: 926 SELDKLSQELEKVGLNRE----LLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVL 981
Query: 128 THFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEE- 186
M E L +Q++++ + LRQ + E + + + ++ KE
Sbjct: 982 LEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAW 1041
Query: 187 ---RDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEEC 243
EL++VKD L A L EK + + + L+ + ++ ++++
Sbjct: 1042 GPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQS 1101
Query: 244 KL--ERNQSLKL---KNDIENRPKKEQVLELERENEMLK---TKNQELQSIIQAGKRSLP 295
E N +L+ K +EN Q L + +L+ T + +Q + L
Sbjct: 1102 AFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLT 1161
Query: 296 DSDKAILDILEH-----DRK----EALEDRQELVNRIY-NLQEEARQAEELRDKYLEEKE 345
+ +A+L EH +R+ EAL + + ++ NL+ E ++ E L+ K
Sbjct: 1162 AAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKA 1221
Query: 346 DLELKCSTLGKDCEMYKHRMNTVMLQLEEVER-----------------ERDQAFHSRDE 388
+LE + L + E + T L + E +R E ++ E
Sbjct: 1222 ELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKE 1281
Query: 389 AQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQS 448
+T + +E ++++ + EL+E++ M I + + L++ LS+ NL++
Sbjct: 1282 LKTSLNNAQLELNRWQARFDELKEQHQTMDISLTK-------LDNHCELLSRLKGNLEEE 1334
Query: 449 LPRNL-PVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQL 507
L + ++SQ + E++ E+ + YH Q++ K L
Sbjct: 1335 NHHLLSQIQLLSQ--------------QNQMLLEQNMENKE---QYHEEQKQYIDKLNAL 1377
Query: 508 QRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPR---SRSSIMSIT 564
+R K + K ++ D P + K+ P+ SR + S
Sbjct: 1378 RRHKEKLEEKIMDQYKF-------YDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTV 1430
Query: 565 AEPPG--NDSIVRRYKEDAPHRSTVEE-DNDSGGFDALDLDDDSHERYSFGPSSIHSSSS 621
PP S P RS E D + G + + D + GP +
Sbjct: 1431 DSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRG 1490
Query: 622 SHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTS 655
S LD D +L R + E R TS
Sbjct: 1491 SPHRGSLDRTD-ASTDLAMRSWPSELGSRTCSTS 1523
Score = 32.0 bits (71), Expect = 3.5
Identities = 77/424 (18%), Positives = 172/424 (40%), Gaps = 58/424 (13%)
Query: 16 KDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGR 75
+D + EN+E R + + KL R+ + ++ + E+ N +L + + +
Sbjct: 697 RDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKA-LGKKSE 755
Query: 76 LLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEV 135
L++ + + +SLE + K T +E + L L E
Sbjct: 756 RLELSYQSVSAENLRLQQSLESS--------SHKTQTLESELGELEAERQALRRDL--EA 805
Query: 136 IKLQQ-QMKAKDLQRCELLARLRQLEDEKK-----------QMTLTRVELLTFQERYYKM 183
++L Q++ + R L + QLE +KK Q+ L L + +
Sbjct: 806 LRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAV 865
Query: 184 KEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEEC 243
++E + + EL + +D A + +L ++ +RDL ++ L + E+
Sbjct: 866 EKESRALDKELARCRD----AAGKLKELEKD-------NRDLTKQVTVHARTLTTLREDL 914
Query: 244 KLERNQSLKLKNDIENRPKKEQVLELERE------NEMLKTKNQELQSIIQAGKRSLPDS 297
LE+ +S +L ++++ ++ + + L RE + TK + L+ ++ ++
Sbjct: 915 VLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAM 974
Query: 298 DKAILDILEHDRKEALEDRQELVNRIYNLQEEAR-------QAEELRDKYLEEKEDLELK 350
+ + +LE +E ++L + + L++E + + L++ + +
Sbjct: 975 KEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG--KTA 1032
Query: 351 CSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIREL 410
S GK+ H+ T+ E+ R +D+A E + + EK ++Q++ L
Sbjct: 1033 ASHQGKEAWGPGHKEATM-----ELLRVKDRAI----ELERNNAALQAEKQLLKEQLQHL 1083
Query: 411 EEKN 414
E +N
Sbjct: 1084 ETQN 1087
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 63.9 bits (154), Expect = 8e-10
Identities = 78/336 (23%), Positives = 137/336 (40%), Gaps = 60/336 (17%)
Query: 132 MNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYN 191
M E IK + QM D + L R Q E E+KQ +ER ++++E +
Sbjct: 1 MMEAIKKKMQMLKLDKENA--LDRAEQAEAEQKQA----------EERSKQLEDELAAMQ 48
Query: 192 DELVKVKD--DNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQ 249
+L +D D Y+ A++ AQ E+ +A ++ D + E+ L R+ +EEE
Sbjct: 49 KKLKGTEDELDKYSEALKDAQ--EKLELAEKKAADAEAEVASLNRRIQLVEEE------- 99
Query: 250 SLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDR 309
L+R E L T Q+L+ +A D + + ++E+
Sbjct: 100 -------------------LDRAQERLATALQKLEEAEKAA-----DESERGMKVIEN-- 133
Query: 310 KEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVM 369
AL+D +++ + L+E AEE KY E++ K + D E + R
Sbjct: 134 -RALKDEEKMELQEIQLKEAKHIAEEADRKY----EEVARKLVIIEGDLERTEERAELAE 188
Query: 370 LQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIV 429
+ E+E E ++ + Q + ++DKY ++I+ L +K E E +
Sbjct: 189 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVA 248
Query: 430 NLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDA 465
LE + L D+ + L IS++ A
Sbjct: 249 KLEKTIDDLE------DELYAQKLKYKAISEELDHA 278
Score = 37.7 bits (86), Expect = 0.064
Identities = 42/223 (18%), Positives = 94/223 (42%), Gaps = 34/223 (15%)
Query: 262 KKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVN 321
KK Q+L+L++EN + + + E + +K+A E ++L +
Sbjct: 7 KKMQMLKLDKENALDRAEQAEAE------------------------QKQAEERSKQLED 42
Query: 322 RIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQ 381
+ +Q++ + E+ DKY E +D + K K + + ++ +++ VE E D+
Sbjct: 43 ELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDR 102
Query: 382 AFHSRDEAQTQYSQCLIEKDKYRKQIRELEEK--NDEMRIEMVRREACIVNLESKLRRLS 439
A A + + D+ + ++ +E + DE ++E+ + + + ++
Sbjct: 103 AQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL------KEAKHIA 156
Query: 440 KDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEE 482
++++ + + R L II D R E+ S EE
Sbjct: 157 EEADRKYEEVARKL--VIIEGDLERTEERAELAESKCSELEEE 197
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,257,499
Number of Sequences: 37866
Number of extensions: 2158371
Number of successful extensions: 15009
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 889
Number of HSP's that attempted gapping in prelim test: 9008
Number of HSP's gapped (non-prelim): 3995
length of query: 1154
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1041
effective length of database: 13,968,660
effective search space: 14541375060
effective search space used: 14541375060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.