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Search of human proteins with 157266309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266309 arylsulfatase E precursor [Homo sapiens]
(589 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266309 arylsulfatase E precursor [Homo sapiens] 1240 0.0
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 771 0.0
gi|58743319 arylsulfatase family, member H [Homo sapiens] 711 0.0
gi|31742482 arylsulfatase F precursor [Homo sapiens] 688 0.0
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 603 e-172
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 380 e-105
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 233 5e-61
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 233 5e-61
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 233 5e-61
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 233 5e-61
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 153 4e-37
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 148 1e-35
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 137 2e-32
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 133 5e-31
gi|45430057 Arylsulfatase G [Homo sapiens] 124 2e-28
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 101 2e-21
gi|109389362 arylsulfatase J [Homo sapiens] 100 3e-21
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 94 5e-19
gi|59797060 arylsulfatase family, member I [Homo sapiens] 91 3e-18
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 60 4e-09
gi|39930577 arylsulfatase K [Homo sapiens] 54 3e-07
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 48 2e-05
gi|189571643 sulfatase 1 [Homo sapiens] 47 6e-05
gi|189571641 sulfatase 1 [Homo sapiens] 47 6e-05
gi|189571638 sulfatase 1 [Homo sapiens] 47 6e-05
gi|189571636 sulfatase 1 [Homo sapiens] 47 6e-05
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 44 4e-04
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 40 0.005
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 40 0.005
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 40 0.005
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 1240 bits (3209), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT 60
MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT
Sbjct: 1 MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT 60
Query: 61 MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG 120
MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG
Sbjct: 61 MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG 120
Query: 121 GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD 180
GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD
Sbjct: 121 GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD 180
Query: 181 CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS 240
CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS
Sbjct: 181 CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS 240
Query: 241 SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV 300
SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV
Sbjct: 241 SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV 300
Query: 301 HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN 360
HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN
Sbjct: 301 HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN 360
Query: 361 QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR 420
QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR
Sbjct: 361 QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR 420
Query: 421 LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV 480
LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV
Sbjct: 421 LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV 480
Query: 481 TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER
Sbjct: 481 TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
Query: 541 VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ 589
VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ
Sbjct: 541 VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ 589
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 771 bits (1990), Expect = 0.0
Identities = 366/576 (63%), Positives = 428/576 (74%)
Query: 12 RSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAE 71
R LP +L + L L +A +PNILL+MADDLG GD+GCYGNNT+RTPNID+LAE
Sbjct: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
Query: 72 DGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAK 131
+GV+LTQH++AA LCTPSRAAFLTGR+ RSGM +S GYR LQW SGGLP NETTFA+
Sbjct: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
Query: 132 ILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRV 191
IL++ GYATGLIGKWH G+NC S DHCHHPL+HGFD+FYGMPF+L DC E
Sbjct: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
Query: 192 NLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHA 251
L +L Q LAL LTL AG+ VS V A L S Y +
Sbjct: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
Query: 252 DCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFL 311
+C LMRNH +TEQPM ++T L+L+E S+++R+KHGPFLLF+S LHVHIPL+T FL
Sbjct: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
Query: 312 GKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWN 371
GKS HGLYGDNVEEMDW++G++L+ ++ GL NST YFTSDHGG LE + G++Q GGWN
Sbjct: 315 GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWN 374
Query: 372 GIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRV 431
GIYKGGKGMGGWEGGIRVPGIF WPGVLPAGRVIGEPTSLMDVFPTVV+L GGEVPQDRV
Sbjct: 375 GIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRV 434
Query: 432 IDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGA 491
IDG L+PLL G S HEFL HYC + LHAARWHQ+D G++WKVH+ TP F PEGAGA
Sbjct: 435 IDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGA 494
Query: 492 CYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRT 551
CYGR VCPC GE V HH PPLLFDLSRDPSE LTP SEP+++ V+ RV AV EH++T
Sbjct: 495 CYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQT 554
Query: 552 LSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDD 587
LSPVP Q +W+PWLQPCCG FP C C + D
Sbjct: 555 LSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGD 590
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 711 bits (1836), Expect = 0.0
Identities = 336/553 (60%), Positives = 407/553 (73%), Gaps = 2/553 (0%)
Query: 36 SRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLT 95
+RPNI+LLMADDLG+GD+ CYGNN++ TPNIDRLA +GV+LTQH++AAS+CTPSRAAFLT
Sbjct: 5 ARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLT 64
Query: 96 GRYPVRSGMVSSIGY-RVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCES 154
GRYP+RSGMVS+ R W G SGGLPTNETTFAK+L+ +GY TGLIGKWHLGL+C S
Sbjct: 65 GRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCAS 124
Query: 155 ASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAG 214
+DHC+HPL+HGF +FYG+PF L+ DC + E L KL LALV L+
Sbjct: 125 RNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFLLLIP 184
Query: 215 KLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPL 274
K V W + AL A L S Y +C LMRNH I +QPM ++ L
Sbjct: 185 KFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEKVASL 244
Query: 275 ILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRIL 334
+L+E +F++R K PFLLF SFLHVH PLI+ + F+G+S +G YGDNVEEMDWMVG+IL
Sbjct: 245 MLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMVGKIL 304
Query: 335 DTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFR 394
D LD E L+N TL+YFTSD+GG LE G Q GGWNGIYKGGKGMGGWEGGIRVPGIFR
Sbjct: 305 DALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFR 364
Query: 395 WPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLM 454
WP VL AGRVI EPTSLMD++PT+ + GG + QDRVIDGQ+L+PLL G A HSDHEFL
Sbjct: 365 WPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLF 424
Query: 455 HYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLF 514
HYC +LH RWHQ+D T+WK H+VTP F PEG GACYG +C C G+ V +HDPPLLF
Sbjct: 425 HYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGD-VTYHDPPLLF 483
Query: 515 DLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCC 574
D+SRDPSE L P +EP+F V+++++ A+ EH+RTL+PVP Q IW+PWLQPCC
Sbjct: 484 DISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWLQPCC 543
Query: 575 GPFPLCWCLREDD 587
G FP C C +EDD
Sbjct: 544 GTFPFCGCDKEDD 556
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 688 bits (1775), Expect = 0.0
Identities = 329/553 (59%), Positives = 415/553 (75%), Gaps = 4/553 (0%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTG 96
+PNI+L+M DDLGIGD+GCYGN+TMRTP+IDRLA +GV+LTQHISAASLC+PSR+AFLTG
Sbjct: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
Query: 97 RYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESAS 156
RYP+RSGMVSS RV+Q GLP NETT A +LK++GY+TGLIGKWH GLNC+S S
Sbjct: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRS 148
Query: 157 DHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKL 216
D CHHP ++GFD++YGMPF+L+ C + E +L Q++A+ LTL GKL
Sbjct: 149 DQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGKL 208
Query: 217 THLIPVSWMPVIWSALSAVLLLASSYFVGALI-VHADCFLMRNHTITEQPMCFQRTTPLI 275
+ + V W+ +I+S + + LL ++F ++ DC LMR H ITEQPM +R ++
Sbjct: 209 SGWVSVPWL-LIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIM 267
Query: 276 LQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILD 335
++E SFL+R+ FLLF SFLHVH PL T ++F G S HGLYGDNVEEMD MVG+ILD
Sbjct: 268 VKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILD 327
Query: 336 TLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRW 395
+D GL N+TL+YFTSDHGG LE + G+ Q GGWNGIYKGGKGMGGWEGGIRVPGI RW
Sbjct: 328 AIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRW 387
Query: 396 PGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMH 455
PG +PAGR+I EPTSLMD+ PTV ++GG +PQDRVIDG+DL+PLL G +HS+HEFL H
Sbjct: 388 PGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFH 447
Query: 456 YCERFLHAARWHQR-DRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLF 514
YC +LHA RW + D G++WK H+VTPVFQP +G CY +C CFGE+V +H+PPLLF
Sbjct: 448 YCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLF 507
Query: 515 DLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCC 574
DLSRDPSE+ LTPA+EP+ V+++V A+ EHQ T+ PV QL L N R WL+PCC
Sbjct: 508 DLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSEL-NQGRTWLKPCC 566
Query: 575 GPFPLCWCLREDD 587
G FP C C +E++
Sbjct: 567 GVFPFCLCDKEEE 579
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 603 bits (1554), Expect = e-172
Identities = 300/556 (53%), Positives = 385/556 (69%), Gaps = 7/556 (1%)
Query: 34 SASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAF 93
+ASRPNI+L+MADDLGIGD GCYGN T+RTPNIDRLA GVKLTQH++A+ LCTPSRAAF
Sbjct: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82
Query: 94 LTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCE 153
+TGRYPVRSGM S V +T +SGGLPT+E TFAK+LK++GY+T LIGKWHLG++C
Sbjct: 83 MTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCH 142
Query: 154 SASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVA 213
S +D CHHPLHHGF++FYG+ + + DC E S ++ + Q++ + LTL A
Sbjct: 143 SKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAA 202
Query: 214 GKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHA--DCFLMRNHTITEQPMCFQRT 271
L+ V + V +S L L+ + F+G L +CF+MRN+ I +QPM +
Sbjct: 203 LNCLGLLHVP-LGVFFSLLFLAALILT-LFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260
Query: 272 TPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVG 331
T + E A F++RN PFLL +S+LHVH L + ++F GKS HG+YGD VEEMDW VG
Sbjct: 261 TQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 320
Query: 332 RILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQ-YGGWNGIYKGGKGMGGWEGGIRVP 390
+IL+ LD L+N TLIYFTSD G +E + +GG NGIYKGGK WEGGIRVP
Sbjct: 321 QILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKA-NNWEGGIRVP 379
Query: 391 GIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDH 450
GI RWP V+ AG+ I EPTS MD+FPTV +LAG +P+DR+IDG+DL+PLL G +Q SDH
Sbjct: 380 GILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDH 439
Query: 451 EFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDP 510
EFL HYC +L+A RWH ++ ++WK F TP F P G+ C+ VC CFG V HHDP
Sbjct: 440 EFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDP 499
Query: 511 PLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWL 570
PLLFD+S+DP E + LTPASEP FY++++ +Q+A H +TL VP Q +W+PWL
Sbjct: 500 PLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWL 559
Query: 571 QPCCGPFPL-CWCLRE 585
Q CC L C C RE
Sbjct: 560 QLCCPSTGLSCQCDRE 575
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 380 bits (975), Expect = e-105
Identities = 187/319 (58%), Positives = 225/319 (70%)
Query: 12 RSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAE 71
R LP +L + L L +A +PNILL+MADDLG GD+GCYGNNT+RTPNID+LAE
Sbjct: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
Query: 72 DGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAK 131
+GV+LTQH++AA LCTPSRAAFLTGR+ RSGM +S GYR LQW SGGLP NETTFA+
Sbjct: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
Query: 132 ILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRV 191
IL++ GYATGLIGKWH G+NC S DHCHHPL+HGFD+FYGMPF+L DC E
Sbjct: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
Query: 192 NLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHA 251
L +L Q LAL LTL AG+ VS V A L S Y +
Sbjct: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
Query: 252 DCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFL 311
+C LMRNH +TEQPM ++T L+L+E S+++R+KHGPFLLF+S LHVHIPL+T FL
Sbjct: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
Query: 312 GKSLHGLYGDNVEEMDWMV 330
GKS HGLYGDNVEEMDW++
Sbjct: 315 GKSQHGLYGDNVEEMDWLI 333
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 233 bits (593), Expect = 5e-61
Identities = 182/561 (32%), Positives = 262/561 (46%), Gaps = 79/561 (14%)
Query: 20 AVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQH 79
++LL+LA + A PNI+L+ ADDLG GD+GCYG+ + TPN+D+LA G++ T
Sbjct: 6 SLLLALAAGLAV---ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62
Query: 80 ISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYA 139
SLCTPSRAA LTGR PVR GM Y + + GGLP E T A++L +GY
Sbjct: 63 YVPVSLCTPSRAALLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYL 117
Query: 140 TGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-MGDCARWELSEKRVNLEQKLN 198
TG+ GKWHLG+ E A P H GF F G+P+S G C + +
Sbjct: 118 TGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
LV + L+A P W+P L + Y A + AD
Sbjct: 174 -----QGLVPIPLLANLSVEAQP-PWLPG----------LEARYMAFAHDLMADA----- 212
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
+ + PF L+ + H H P + ++F +S G
Sbjct: 213 --------------------------QRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
+GD++ E+D VG ++ + GL TL+ FT+D+G + GG +G+ + GK
Sbjct: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGK 302
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
G +EGG+R P + WPG + G V E S +D+ PT+ LAG +P + +DG DL
Sbjct: 303 GT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLS 359
Query: 439 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVC 498
PLLLGT + S + L Y + R R +K HF T Q C
Sbjct: 360 PLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFT---QGSAHSDTTADPAC 414
Query: 499 PCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFYQVMERVQQAVWEHQRTLSPV 555
+ H+PPLL+DLS+DP E + L + P Q ++++Q + ++
Sbjct: 415 HA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 473
Query: 556 PLQLDRLGNIWRPWLQPCCGP 576
P Q+ R + P LQ CC P
Sbjct: 474 PSQVARGED---PALQICCHP 491
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 233 bits (593), Expect = 5e-61
Identities = 182/561 (32%), Positives = 262/561 (46%), Gaps = 79/561 (14%)
Query: 20 AVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQH 79
++LL+LA + A PNI+L+ ADDLG GD+GCYG+ + TPN+D+LA G++ T
Sbjct: 6 SLLLALAAGLAV---ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62
Query: 80 ISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYA 139
SLCTPSRAA LTGR PVR GM Y + + GGLP E T A++L +GY
Sbjct: 63 YVPVSLCTPSRAALLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYL 117
Query: 140 TGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-MGDCARWELSEKRVNLEQKLN 198
TG+ GKWHLG+ E A P H GF F G+P+S G C + +
Sbjct: 118 TGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
LV + L+A P W+P L + Y A + AD
Sbjct: 174 -----QGLVPIPLLANLSVEAQP-PWLPG----------LEARYMAFAHDLMADA----- 212
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
+ + PF L+ + H H P + ++F +S G
Sbjct: 213 --------------------------QRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
+GD++ E+D VG ++ + GL TL+ FT+D+G + GG +G+ + GK
Sbjct: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGK 302
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
G +EGG+R P + WPG + G V E S +D+ PT+ LAG +P + +DG DL
Sbjct: 303 GT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLS 359
Query: 439 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVC 498
PLLLGT + S + L Y + R R +K HF T Q C
Sbjct: 360 PLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFT---QGSAHSDTTADPAC 414
Query: 499 PCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFYQVMERVQQAVWEHQRTLSPV 555
+ H+PPLL+DLS+DP E + L + P Q ++++Q + ++
Sbjct: 415 HA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 473
Query: 556 PLQLDRLGNIWRPWLQPCCGP 576
P Q+ R + P LQ CC P
Sbjct: 474 PSQVARGED---PALQICCHP 491
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 233 bits (593), Expect = 5e-61
Identities = 182/561 (32%), Positives = 262/561 (46%), Gaps = 79/561 (14%)
Query: 20 AVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQH 79
++LL+LA + A PNI+L+ ADDLG GD+GCYG+ + TPN+D+LA G++ T
Sbjct: 6 SLLLALAAGLAV---ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62
Query: 80 ISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYA 139
SLCTPSRAA LTGR PVR GM Y + + GGLP E T A++L +GY
Sbjct: 63 YVPVSLCTPSRAALLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYL 117
Query: 140 TGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-MGDCARWELSEKRVNLEQKLN 198
TG+ GKWHLG+ E A P H GF F G+P+S G C + +
Sbjct: 118 TGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
LV + L+A P W+P L + Y A + AD
Sbjct: 174 -----QGLVPIPLLANLSVEAQP-PWLPG----------LEARYMAFAHDLMADA----- 212
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
+ + PF L+ + H H P + ++F +S G
Sbjct: 213 --------------------------QRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
+GD++ E+D VG ++ + GL TL+ FT+D+G + GG +G+ + GK
Sbjct: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGK 302
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
G +EGG+R P + WPG + G V E S +D+ PT+ LAG +P + +DG DL
Sbjct: 303 GT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLS 359
Query: 439 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVC 498
PLLLGT + S + L Y + R R +K HF T Q C
Sbjct: 360 PLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFT---QGSAHSDTTADPAC 414
Query: 499 PCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFYQVMERVQQAVWEHQRTLSPV 555
+ H+PPLL+DLS+DP E + L + P Q ++++Q + ++
Sbjct: 415 HA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 473
Query: 556 PLQLDRLGNIWRPWLQPCCGP 576
P Q+ R + P LQ CC P
Sbjct: 474 PSQVARGED---PALQICCHP 491
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 233 bits (593), Expect = 5e-61
Identities = 182/561 (32%), Positives = 262/561 (46%), Gaps = 79/561 (14%)
Query: 20 AVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQH 79
++LL+LA + A PNI+L+ ADDLG GD+GCYG+ + TPN+D+LA G++ T
Sbjct: 6 SLLLALAAGLAV---ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62
Query: 80 ISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYA 139
SLCTPSRAA LTGR PVR GM Y + + GGLP E T A++L +GY
Sbjct: 63 YVPVSLCTPSRAALLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYL 117
Query: 140 TGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-MGDCARWELSEKRVNLEQKLN 198
TG+ GKWHLG+ E A P H GF F G+P+S G C + +
Sbjct: 118 TGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
LV + L+A P W+P L + Y A + AD
Sbjct: 174 -----QGLVPIPLLANLSVEAQP-PWLPG----------LEARYMAFAHDLMADA----- 212
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
+ + PF L+ + H H P + ++F +S G
Sbjct: 213 --------------------------QRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
+GD++ E+D VG ++ + GL TL+ FT+D+G + GG +G+ + GK
Sbjct: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGK 302
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
G +EGG+R P + WPG + G V E S +D+ PT+ LAG +P + +DG DL
Sbjct: 303 GT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLS 359
Query: 439 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVC 498
PLLLGT + S + L Y + R R +K HF T Q C
Sbjct: 360 PLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFT---QGSAHSDTTADPAC 414
Query: 499 PCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFYQVMERVQQAVWEHQRTLSPV 555
+ H+PPLL+DLS+DP E + L + P Q ++++Q + ++
Sbjct: 415 HA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 473
Query: 556 PLQLDRLGNIWRPWLQPCCGP 576
P Q+ R + P LQ CC P
Sbjct: 474 PSQVARGED---PALQICCHP 491
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 153 bits (387), Expect = 4e-37
Identities = 135/461 (29%), Positives = 200/461 (43%), Gaps = 71/461 (15%)
Query: 120 GGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-M 178
GGLP E T A++L +GY TG+ GKWHLG+ E A P H GF F G+P+S
Sbjct: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQ 69
Query: 179 GDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLL 238
G C + + LV + L+A P W+P L
Sbjct: 70 GPCQNLTCFPPATPCDGGCD-----QGLVPIPLLANLSVEAQP-PWLPG----------L 113
Query: 239 ASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFL 298
+ Y A + AD + + PF L+ +
Sbjct: 114 EARYMAFAHDLMADA-------------------------------QRQDRPFFLYYASH 142
Query: 299 HVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSL 358
H H P + ++F +S G +GD++ E+D VG ++ + GL TL+ FT+D+G
Sbjct: 143 HTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG--- 199
Query: 359 ENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTV 418
+ GG +G+ + GKG +EGG+R P + WPG + G V E S +D+ PT+
Sbjct: 200 -PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTL 256
Query: 419 VRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVH 478
LAG +P + +DG DL PLLLGT + S + L Y + R R +K H
Sbjct: 257 AALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAH 313
Query: 479 FVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFY 535
F T Q C + H+PPLL+DLS+DP E + L + P
Sbjct: 314 FFT---QGSAHSDTTADPACHA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVL 369
Query: 536 QVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGP 576
Q ++++Q + ++ P Q+ R + P LQ CC P
Sbjct: 370 QALKQLQLLKAQLDAAVTFGPSQVARGED---PALQICCHP 407
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 148 bits (374), Expect = 1e-35
Identities = 112/324 (34%), Positives = 158/324 (48%), Gaps = 19/324 (5%)
Query: 272 TPLILQEVASFLKRN-KHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMV 330
T + LQE F+KR +H PF L+ + H P+ + FLG S G YGD V E+D +
Sbjct: 206 TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSI 265
Query: 331 GRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVP 390
G+IL+ L ++++T ++FTSD+G +L + + GG NG + GK +EGG+R P
Sbjct: 266 GKILELLQDLHVADNTFVFFTSDNGAAL---ISAPEQGGSNGPFLCGK-QTTFEGGMREP 321
Query: 391 GIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDH 450
+ WPG + AG+V + S+MD+F T + LAG P DR IDG +LLP LL + D
Sbjct: 322 ALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDR 380
Query: 451 EFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPE----GAGACYGRKVCPCFGEKVV 506
+ +Y L AA Q K HF T E G C G+ V +
Sbjct: 381 P-IFYYRGDTLMAATLGQH------KAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLE 433
Query: 507 HHDP-PLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNI 565
H PL+F L RDP E L+ AS + + + R+ V +HQ L P QL+
Sbjct: 434 DHTKLPLIFHLGRDPGERFPLSFASAE-YQEALSRITSVVQQHQEALVPAQPQLNVCNWA 492
Query: 566 WRPWLQPCCGPFPLCWCLREDDPQ 589
W P C C E P+
Sbjct: 493 VMNWAPPGCEKLGKCLTPPESIPK 516
Score = 126 bits (317), Expect = 5e-29
Identities = 66/158 (41%), Positives = 96/158 (60%), Gaps = 9/158 (5%)
Query: 19 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ 78
L ++LS A +S + PNILLL+ DD+G GD+G YG + TPN+DR+A +G+
Sbjct: 13 LLLVLSAAGMGASG-APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPN 71
Query: 79 HISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGAS--GGLPTNETTFAKILKEK 136
SA LC+PSRAA LTGR P+R+G ++ + +T GG+P +E ++LK+
Sbjct: 72 FYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKA 131
Query: 137 GYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMP 174
GY + ++GKWHLG + HPL HGFD ++G P
Sbjct: 132 GYVSKIVGKWHLGHRPQ------FHPLKHGFDEWFGSP 163
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 137 bits (346), Expect = 2e-32
Identities = 160/586 (27%), Positives = 243/586 (41%), Gaps = 112/586 (19%)
Query: 19 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ 78
L +LL LAP S ++ P+++ L+ADDLG D+G +G+ +RTP++D LA GV L
Sbjct: 26 LLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDN 84
Query: 79 HISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGY 138
+ + LCTPSR+ LTGRY +R+G+ I W +P +E ++LKE GY
Sbjct: 85 YYTQP-LCTPSRSQLLTGRYQIRTGLQHQI-----IWPCQPSCVPLDEKLLPQLLKEAGY 138
Query: 139 ATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLN 198
T ++GKWHLG+ + P GFD ++G L+G + S +R L LN
Sbjct: 139 TTHMVGKWHLGMYRKECL-----PTRRGFDTYFGY---LLG--SEDYYSHERCTLIDALN 188
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
+ AL G+ A + +++ F I L+ N
Sbjct: 189 -----VTRCALDFRDGEEV-------------ATGYKNMYSTNIFTKRAIA-----LITN 225
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
H E+P+ L LQ V H P + +L + +F+
Sbjct: 226 HP-PEKPLFLY----LALQSV--------HEPLQVPEEYLKPY-------DFIQDKNRHH 265
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
Y V MD VG + L GL N+T+ F++D+G G T GG N +G K
Sbjct: 266 YAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNG-------GQTLAGGNNWPLRGRK 318
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
WEGG+R G P + G E + D PT+V+LA G + +DG D+
Sbjct: 319 -WSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVW 377
Query: 439 PLLLGTAQHSDHEFLMHYCERFLHAA------------------------RWHQRDRGTM 474
+ + E L + F+ ++ H R
Sbjct: 378 KTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGN 437
Query: 475 WKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPL----LFDLSRDPSETHILTPAS 530
WK+ P G G + E + DPP LFD+ RDP E H L+
Sbjct: 438 WKLLTGYP-----GCGYWFPPPSQYNVSE-IPSSDPPTKTLWLFDIDRDPEERHDLSREY 491
Query: 531 EPVFYQVMERVQQAVWEHQRTLSPV--PLQLDRLG----NIWRPWL 570
+ +++ R+Q + H+ ++ PV P Q R +W PW+
Sbjct: 492 PHIVTKLLSRLQ---FYHKHSV-PVYFPAQDPRCDPKATGVWGPWM 533
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 133 bits (334), Expect = 5e-31
Identities = 126/419 (30%), Positives = 187/419 (44%), Gaps = 68/419 (16%)
Query: 19 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ 78
L +LL LAP S ++ P+++ L+ADDLG D+G +G+ +RTP++D LA GV L
Sbjct: 26 LLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDN 84
Query: 79 HISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGY 138
+ + LCTPSR+ LTGRY +R+G+ I W +P +E ++LKE GY
Sbjct: 85 YYTQP-LCTPSRSQLLTGRYQIRTGLQHQI-----IWPCQPSCVPLDEKLLPQLLKEAGY 138
Query: 139 ATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLN 198
T ++GKWHLG+ + P GFD ++G L+G + S +R L LN
Sbjct: 139 TTHMVGKWHLGMYRKECL-----PTRRGFDTYFGY---LLG--SEDYYSHERCTLIDALN 188
Query: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
+ AL G+ A + +++ F I L+ N
Sbjct: 189 -----VTRCALDFRDGEEV-------------ATGYKNMYSTNIFTKRAIA-----LITN 225
Query: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
H E+P+ L LQ V H P + +L + +F+
Sbjct: 226 HP-PEKPLFLY----LALQSV--------HEPLQVPEEYLKPY-------DFIQDKNRHH 265
Query: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
Y V MD VG + L GL N+T+ F++D+G G T GG N +G K
Sbjct: 266 YAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNG-------GQTLAGGNNWPLRGRK 318
Query: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDL 437
WEGG+R G P + G E + D PT+V+LA G + +DG D+
Sbjct: 319 -WSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 376
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 124 bits (312), Expect = 2e-28
Identities = 59/147 (40%), Positives = 91/147 (61%), Gaps = 12/147 (8%)
Query: 30 SSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPS 89
S +PN ++++ADD+G GD+G T T N+D++A +G++ +AAS C+PS
Sbjct: 28 SGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPS 87
Query: 90 RAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLG 149
RA+ LTGR +R+G+ + + GGLP NETT A++L++ GY TG+IGKWHLG
Sbjct: 88 RASLLTGRLGLRNGVTRNFA------VTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLG 141
Query: 150 LNCESASDHCHHPLHHGFDHFYGMPFS 176
+HP GFD+++G+P+S
Sbjct: 142 ------HHGSYHPNFRGFDYYFGIPYS 162
Score = 114 bits (286), Expect = 2e-25
Identities = 96/345 (27%), Positives = 150/345 (43%), Gaps = 30/345 (8%)
Query: 252 DCF------LMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHG--PFLLFVSFLHVHIP 303
DC+ L N I EQP+ ++ F++R PFLL+V+ H+H+P
Sbjct: 194 DCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVP 253
Query: 304 LITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLG 363
L + LYG + EMD +VG+I D +D + +T ++FT D+G +
Sbjct: 254 LPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVD-HTVKENTFLWFTGDNGPWAQKCEL 312
Query: 364 NTQYGGWNGIYKGGKG-----MGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTV 418
G + G ++ +G WEGG RVP + WPG +P S++D+FPTV
Sbjct: 313 AGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTV 372
Query: 419 VRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVH 478
V LA +PQ R DG D+ +L G +Q H L H Q R +K
Sbjct: 373 VALAQASLPQGRRFDGVDVSEVLFGRSQ-PGHRVLFHPNSGAAGEFGALQTVRLERYKAF 431
Query: 479 FVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVM 538
++T GA AC G + H PL+F+L D +E L + V+
Sbjct: 432 YIT-----GGARACDGST------GPELQHKFPLIFNLEDDTAEAVPLERGGAE-YQAVL 479
Query: 539 ERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPL-CWC 582
V++ + + + ++ + P + PCC P+ + C C
Sbjct: 480 PEVRKVLADVLQDIAND--NISSADYTQDPSVTPCCNPYQIACRC 522
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 101 bits (251), Expect = 2e-21
Identities = 119/459 (25%), Positives = 186/459 (40%), Gaps = 96/459 (20%)
Query: 14 WLPAMLA-VLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAED 72
WL +L+ V ++L ++ + N+LL++ DDL +GCYG+ +R+PNID+LA
Sbjct: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
Query: 73 GVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKI 132
+ + ++C PSR +FLTGR P + + Y W +G N +T +
Sbjct: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQY 122
Query: 133 LKEKGYATGLIGK-WHLGLNCESASDHCH---HPLHHGFDHFYGMPFSLMGDCARWELSE 188
KE GY T +GK +H G++ D + P +H Y + G
Sbjct: 123 FKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGP-------- 174
Query: 189 KRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLL-----ASSYF 243
+ E N L V L +P +P S A+ LL ++S F
Sbjct: 175 ---DGELHANLLCPVDVLD------------VPEGTLPDKQSTEQAIQLLEKMKTSASPF 219
Query: 244 VGALIVHADCFLMRNHTITEQPMCFQRTTPLIL------QEVASFLKRNKHGPFLLF--- 294
A+ H + H P FQ+ PL EV L + P++
Sbjct: 220 FLAVGYH------KPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273
Query: 295 --VSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTS 352
V L++ +P + + + Y +V +D VGR+L LD L+NST+I FTS
Sbjct: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333
Query: 353 DHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPG--------------- 397
DHG +L ++G W ++ VP IF PG
Sbjct: 334 DHGWAL------GEHGEW-------AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY 380
Query: 398 ---------VLPAGRVIGEPTSLMDVFPTVVRLAGGEVP 427
++ GR + L+ +FPT+ LAG +VP
Sbjct: 381 LDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 100 bits (250), Expect = 3e-21
Identities = 58/149 (38%), Positives = 88/149 (59%), Gaps = 15/149 (10%)
Query: 31 SDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSR 90
S S S+P+++ ++ADD G D+G +G+ ++TP +D+LA +GVKL + +CTPSR
Sbjct: 69 STTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYY-VQPICTPSR 126
Query: 91 AAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGL 150
+ F+TG+Y + +G+ SI R Q LP + T + LKE GY+T ++GKWHLG
Sbjct: 127 SQFITGKYQIHTGLQHSI-IRPTQ----PNCLPLDNATLPQKLKEVGYSTHMVGKWHLGF 181
Query: 151 NCESASDHCHHPLHHGFDHFYGMPFSLMG 179
+ P GFD F+G SL+G
Sbjct: 182 YRKECM-----PTRRGFDTFFG---SLLG 202
Score = 68.6 bits (166), Expect = 2e-11
Identities = 78/336 (23%), Positives = 133/336 (39%), Gaps = 56/336 (16%)
Query: 271 TTPLILQEVASFL-KRNKHGPFLLFVSFLHVHIPLITMENFLG--KSLHGL----YGDNV 323
+T + Q V L N P L++++ VH PL + +S+ + Y +
Sbjct: 238 STQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAML 297
Query: 324 EEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGW 383
+D + + L G N+++I ++SD+GG GG N +G KG W
Sbjct: 298 SCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQ-------PTAGGSNWPLRGSKGTY-W 349
Query: 384 EGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLG 443
EGGIR G P + G V E + D +PT++ LA G++ +D +DG D+ +
Sbjct: 350 EGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWE-TIS 408
Query: 444 TAQHSDHEFLMHYCERFLHAAR----------WHQRDRGTM----WKVHFVTP------- 482
S ++H + A+ W+ + + WK+ P
Sbjct: 409 EGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVP 468
Query: 483 --VFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
F G + ++ G+ V LF+++ DP E L+ + +++ R
Sbjct: 469 PQSFSNLGPNRWHNERITLSTGKSV------WLFNITADPYERVDLSNRYPGIVKKLLRR 522
Query: 541 VQQAVWEHQRTLSPV------PLQLDRL-GNIWRPW 569
+ Q +T PV P RL G +W PW
Sbjct: 523 LSQ----FNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 93.6 bits (231), Expect = 5e-19
Identities = 99/363 (27%), Positives = 154/363 (42%), Gaps = 59/363 (16%)
Query: 14 WLPAMLA-VLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAED 72
WL +L+ V ++L ++ + N+LL++ DDL +GCYG+ +R+PNID+LA
Sbjct: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
Query: 73 GVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKI 132
+ + ++C PSR +FLTGR P + + Y W +G N +T +
Sbjct: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQY 122
Query: 133 LKEKGYATGLIGK-WHLGLNCESASDHCH---HPLHHGFDHFYGMPFSLMGDCARWELSE 188
KE GY T +GK +H G++ D + P +H Y + G
Sbjct: 123 FKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGP-------- 174
Query: 189 KRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLL-----ASSYF 243
+ E N L V L +P +P S A+ LL ++S F
Sbjct: 175 ---DGELHANLLCPVDVLD------------VPEGTLPDKQSTEQAIQLLEKMKTSASPF 219
Query: 244 VGALIVHADCFLMRNHTITEQPMCFQRTTPLIL------QEVASFLKRNKHGPFLLF--- 294
A+ H + H P FQ+ PL EV L + P++
Sbjct: 220 FLAVGYH------KPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273
Query: 295 --VSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTS 352
V L++ +P + + + Y +V +D VGR+L LD L+NST+I FTS
Sbjct: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333
Query: 353 DHG 355
DHG
Sbjct: 334 DHG 336
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 90.9 bits (224), Expect = 3e-18
Identities = 53/135 (39%), Positives = 77/135 (57%), Gaps = 12/135 (8%)
Query: 38 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGR 97
P+I+ ++ DD G D+G +G++ + TP +DRLA GVKL + +CTPSR+ LTGR
Sbjct: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYY-IQPICTPSRSQLLTGR 104
Query: 98 YPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASD 157
Y + +G+ SI R Q LP ++ T + L+E GY+T ++GKWHLG +
Sbjct: 105 YQIHTGLQHSI-IRPQQ----PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECL- 158
Query: 158 HCHHPLHHGFDHFYG 172
P GFD F G
Sbjct: 159 ----PTRRGFDTFLG 169
Score = 67.8 bits (164), Expect = 3e-11
Identities = 87/336 (25%), Positives = 127/336 (37%), Gaps = 53/336 (15%)
Query: 269 QRTTPLILQEVASFL-KRNKHGPFLLFVSFLHVHIPLITMENFL------GKSLHGLYGD 321
Q +T L Q + L + P L+V+F VH PL + +L G Y
Sbjct: 206 QYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAA 265
Query: 322 NVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMG 381
V MD V I L G N+++I F+SD+G G T GG N +G KG
Sbjct: 266 MVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNG-------GQTFSGGSNWPLRGRKGT- 317
Query: 382 GWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
WEGG+R G P + R + D +PT+V LAGG +DG D+ P +
Sbjct: 318 YWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAI 377
Query: 442 LGTAQHSDHEFLMHYCERFLHAAR---------WHQRDRGTM----WKV--------HFV 480
E L + + HA W+ + + WK+ ++
Sbjct: 378 SEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWI 437
Query: 481 TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
P G+ + + + V LF++S DP E L V ++ R
Sbjct: 438 PPQTLATFPGSWWNLERMASVRQAV------WLFNISADPYEREDLAGQRPDVVRTLLAR 491
Query: 541 VQQAVWEHQRTLSPV--PLQLDRL-----GNIWRPW 569
+ E+ RT PV P + R G W PW
Sbjct: 492 LA----EYNRTAIPVRYPAENPRAHPDFNGGAWGPW 523
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 60.5 bits (145), Expect = 4e-09
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 14/136 (10%)
Query: 15 LPAMLAVLLSLAPSASSDISASRP-NILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDG 73
+PA A+LL L + +RP N LLL+ADD G + G Y N+ + TP++D LA
Sbjct: 5 VPACCALLLVLG------LCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRS 57
Query: 74 VKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKIL 133
+ ++ S C+PSRA+ LTG ++GM Y + Q + +L
Sbjct: 58 LLFRNAFTSVSSCSPSRASLLTGLPQHQNGM-----YGLHQDVHHFNSF-DKVRSLPLLL 111
Query: 134 KEKGYATGLIGKWHLG 149
+ G TG+IGK H+G
Sbjct: 112 SQAGVRTGIIGKKHVG 127
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/251 (27%), Positives = 97/251 (38%), Gaps = 47/251 (18%)
Query: 323 VEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGG 382
V MD VG +L L G+ N TL+ FTSD+G + G +Y G
Sbjct: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPS--------GRTNLYWPGTAEPL 294
Query: 383 WEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRV-------IDGQ 435
P RW G+V SL+D+ PT++ P + + G+
Sbjct: 295 LVSSPEHPK--RW------GQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGR 346
Query: 436 DLLPLLLGT-------AQHSDHEFLMHYCERFL---HAARWHQRDRGTMWKV---HFVTP 482
LLP L S HE M Y R + H H + + + +V+P
Sbjct: 347 SLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSP 406
Query: 483 VFQPEGAGACYGRKVCPCFGEKVVHH----DPPLLFDLSRDPSETHILTPASEPVFYQVM 538
FQ G+ P K + H L+D SRDP ET L A++P F Q++
Sbjct: 407 TFQDLLNRTTAGQ---PTGWYKDLRHYYYRARWELYDRSRDPHETQNL--ATDPRFAQLL 461
Query: 539 E--RVQQAVWE 547
E R Q A W+
Sbjct: 462 EMLRDQLAKWQ 472
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/128 (31%), Positives = 64/128 (50%), Gaps = 16/128 (12%)
Query: 313 KSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNG 372
K++ Y E D M+G I+ L L T++ ++SDHG E + + Q+
Sbjct: 273 KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQF----- 324
Query: 373 IYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVI 432
YK M +E VP + PG+ AG + SL+D++PT++ +AG +PQ+ +
Sbjct: 325 -YK----MSMYEASAHVPLLMMGPGI-KAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--L 376
Query: 433 DGQDLLPL 440
G LLPL
Sbjct: 377 SGYSLLPL 384
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/135 (25%), Positives = 59/135 (43%), Gaps = 14/135 (10%)
Query: 14 WLPAMLAVLLS-LAPSASSDI--SASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLA 70
W+ + A+ L+ LAP A +A PN++L+++D G+ ++ P I+ +
Sbjct: 5 WVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMK 64
Query: 71 EDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFA 130
G + + +C PSRAA +G + + W G L N TT+
Sbjct: 65 TRGTSFLNAYTNSPICCPSRAAMWSGLFT----------HLTESWNNFKG-LDPNYTTWM 113
Query: 131 KILKEKGYATGLIGK 145
+++ GY T GK
Sbjct: 114 DVMERHGYRTQKFGK 128
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 8/85 (9%)
Query: 61 MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG 120
++ PNID+LA + + ++C PSR +FLTGR P + + Y W +G
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG 77
Query: 121 GLPTNETTFAKILKEKGYATGLIGK 145
N +T + KE GY T +GK
Sbjct: 78 ----NFSTIPQYFKENGYVTMSVGK 98
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEG 385
+D V R+ + L G +T I +T+DHG + G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 386 GIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
IRVP R P V P G ++ + +D+ PT++ +AG + P D +DG+ +L LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 37.0 bits (84), Expect = 0.051
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +++ N R + G +C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y + ++ + S TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNE----NCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEG 385
+D V R+ + L G +T I +T+DHG + G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 386 GIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
IRVP R P V P G ++ + +D+ PT++ +AG + P D +DG+ +L LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 37.0 bits (84), Expect = 0.051
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +++ N R + G +C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y + ++ + S TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNE----NCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEG 385
+D V R+ + L G +T I +T+DHG + G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 386 GIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
IRVP R P V P G ++ + +D+ PT++ +AG + P D +DG+ +L LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 37.0 bits (84), Expect = 0.051
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +++ N R + G +C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y + ++ + S TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNE----NCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEG 385
+D V R+ + L G +T I +T+DHG + G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 386 GIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
IRVP R P V P G ++ + +D+ PT++ +AG + P D +DG+ +L LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 37.0 bits (84), Expect = 0.051
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +++ N R + G +C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y + ++ + S TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNE----NCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/146 (28%), Positives = 60/146 (41%), Gaps = 25/146 (17%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTG 96
RPN++LL+ DD G T + E G+ + ++LC PSRA+ LTG
Sbjct: 46 RPNVVLLLTDDQD----EVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
Query: 97 RYP--------VRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEK-GYATGLIGKWH 147
+YP G SS ++ +Q TF IL+ GY T GK+
Sbjct: 102 KYPHNHHVVNNTLEGNCSSKSWQKIQ----------EPNTFPAILRSMCGYQTFFAGKYL 151
Query: 148 LGLNCESASDHCHHPLHHGFDHFYGM 173
A H PL G+ ++Y +
Sbjct: 152 NEYGAPDAGGLEHVPL--GWSYWYAL 175
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/123 (26%), Positives = 62/123 (50%), Gaps = 20/123 (16%)
Query: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHG---GSLENQLGNTQYGGWNGIYKGGKGMGG 382
+D +V +++ L+ G N+T I++TSD+G G + Q
Sbjct: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQL--------------- 343
Query: 383 WEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLL 442
+E I+VP + R PG+ P + + +D+ PT++ +AG ++ + + +DG LLP+L
Sbjct: 344 YEFDIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILR 401
Query: 443 GTA 445
G +
Sbjct: 402 GAS 404
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 40.4 bits (93), Expect = 0.005
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 333 ILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGI 392
I + L G ++T I +T+DHG + G G+ KG K M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVKG-KSMP-YEFDIRVPFY 344
Query: 393 FRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
R P V AG + +D+ PT++ +AG ++P D +DG+ +L LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 38.9 bits (89), Expect = 0.013
Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +M+ N R + + G +C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y ++ + S TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNE----NCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 40.4 bits (93), Expect = 0.005
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 333 ILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGI 392
I + L G ++T I +T+DHG + G G+ KG K M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVKG-KSMP-YEFDIRVPFY 344
Query: 393 FRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
R P V AG + +D+ PT++ +AG ++P D +DG+ +L LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 38.9 bits (89), Expect = 0.013
Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +M+ N R + + G +C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y ++ + S TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNE----NCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 40.4 bits (93), Expect = 0.005
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 333 ILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGI 392
I + L G ++T I +T+DHG + G G+ KG K M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVKG-KSMP-YEFDIRVPFY 344
Query: 393 FRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
R P V AG + +D+ PT++ +AG ++P D +DG+ +L LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 38.9 bits (89), Expect = 0.013
Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
RPNI+L++ DD + ++G +M+ N R + + G +C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
TG+Y ++ + S TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNE----NCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.464
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,554,874
Number of Sequences: 37866
Number of extensions: 1185324
Number of successful extensions: 3668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 3499
Number of HSP's gapped (non-prelim): 84
length of query: 589
length of database: 18,247,518
effective HSP length: 108
effective length of query: 481
effective length of database: 14,157,990
effective search space: 6809993190
effective search space used: 6809993190
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.