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Search of human proteins with 11034845
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11034845 Regulation of nuclear pre-mRNA domain containing 1B
[Homo sapiens]
(326 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11034845 Regulation of nuclear pre-mRNA domain containing 1B ... 635 0.0
gi|21361709 regulation of nuclear pre-mRNA domain containing 1A ... 412 e-115
gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 ... 108 6e-24
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 47 2e-05
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 47 2e-05
gi|33620745 pre-mRNA cleavage complex II protein Pcf11 [Homo sap... 46 4e-05
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 46 5e-05
gi|55770834 centromere protein F [Homo sapiens] 45 7e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 43 3e-04
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 42 6e-04
gi|62460633 RNA-binding motif protein 16 [Homo sapiens] 42 7e-04
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 42 7e-04
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens] 42 0.001
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 42 0.001
gi|38044112 restin isoform b [Homo sapiens] 41 0.001
gi|4506751 restin isoform a [Homo sapiens] 41 0.001
gi|31982906 cingulin-like 1 [Homo sapiens] 41 0.001
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 40 0.003
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 40 0.003
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 40 0.003
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 40 0.004
gi|42794779 myosin 18A isoform b [Homo sapiens] 40 0.004
gi|28416946 myosin 18A isoform a [Homo sapiens] 40 0.004
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 40 0.004
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 39 0.005
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 39 0.005
gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens] 39 0.005
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 39 0.005
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 39 0.006
gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo sap... 39 0.008
>gi|11034845 Regulation of nuclear pre-mRNA domain containing 1B
[Homo sapiens]
Length = 326
Score = 635 bits (1638), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 1 MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL 60
MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL
Sbjct: 1 MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL 60
Query: 61 YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE 120
YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE
Sbjct: 61 YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE 120
Query: 121 FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL 180
FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL
Sbjct: 121 FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL 180
Query: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY
Sbjct: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
Query: 241 NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL
Sbjct: 241 NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
Query: 301 PDLSLLPNVTGGLAPLPSAGDLFSTD 326
PDLSLLPNVTGGLAPLPSAGDLFSTD
Sbjct: 301 PDLSLLPNVTGGLAPLPSAGDLFSTD 326
>gi|21361709 regulation of nuclear pre-mRNA domain containing 1A
[Homo sapiens]
Length = 312
Score = 412 bits (1060), Expect = e-115
Identities = 213/326 (65%), Positives = 262/326 (80%), Gaps = 14/326 (4%)
Query: 1 MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL 60
MS+FSE+ALEKKLSELSNSQQSVQTLSLWLIHHRKH+ PIV+VW RELRKAK NRKLTFL
Sbjct: 1 MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFL 60
Query: 61 YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE 120
YLANDVIQNSKRKGPEFT++F V+V+AF HV+ E DE CKK L R+L+IW+ERSVY +
Sbjct: 61 YLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYEND 120
Query: 121 FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL 180
++QLK ++ K P KRT++QI+ +E+++ SP +P T +L
Sbjct: 121 VLEQLKQALYGDKKPR----------KRTYEQIKVDENENCSSLGSPSEPPQ----TLDL 166
Query: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
++ALQDLENAASGDA V Q+IASLP EVQ+VSLL+KITDKE+ ERLSK V++AC+LLA+Y
Sbjct: 167 VRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADY 226
Query: 241 NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
NGRLAAE++DR+QL RML ++ + QK+ L+EKE KLEEYK+KLARV+ VRKEL+S IQSL
Sbjct: 227 NGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVRKELRSRIQSL 286
Query: 301 PDLSLLPNVTGGLAPLPSAGDLFSTD 326
PDLS LPNVTG LP AGD++S D
Sbjct: 287 PDLSRLPNVTGSHMHLPFAGDIYSED 312
>gi|183396804 Regulation of nuclear pre-mRNA domain containing 2
[Homo sapiens]
Length = 1461
Score = 108 bits (270), Expect = 6e-24
Identities = 85/325 (26%), Positives = 151/325 (46%), Gaps = 22/325 (6%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLAND 65
ES+L++K ++N+ +S+Q LS W I ++KH IV W + LR++ +L YLAND
Sbjct: 24 ESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRLNLFYLAND 83
Query: 66 VIQNSKRKGPEFTRE-FESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQ 124
VIQN KRK RE F VL +A A D K +ER+ IW++R+VY E I
Sbjct: 84 VIQNCKRKNAIIFRESFADVLPEA---AALVKDPSVSKSVERIFKIWEDRNVYPEEMIVA 140
Query: 125 LKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSA-------GPLLT 177
L+ ++ + K+ K+ + + ++ + + S + +P A +
Sbjct: 141 LREALSTT----------FKTQKQLKENLNKQPNKQWKKSQTSTNPKAALKSKIVAEFRS 190
Query: 178 EELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLL 237
+ LI+ L + + ++++++ +V L+ + DK ++ SK +EA L
Sbjct: 191 QALIEELLLYKRSEDQIELKEKQLSTMRVDVCSTETLKCLKDKTGGKKFSKEFEEASSKL 250
Query: 238 AEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHI 297
E+ L ++++ L L + E + YK RV ++K+L
Sbjct: 251 EEFVNGLDKQVKNGPSLTEALENAGIFYEAQYKEVKVVANAYKTFANRVNNLKKKLDQLK 310
Query: 298 QSLPDLSLLPNVTGGL-APLPSAGD 321
+LPD P + + AP P+ +
Sbjct: 311 STLPDPEESPVPSPSMDAPSPTGSE 335
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 47.0 bits (110), Expect = 2e-05
Identities = 63/286 (22%), Positives = 121/286 (42%), Gaps = 61/286 (21%)
Query: 67 IQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLE---------RLLNIWQERSVY 117
++NS + E +E E+++ + + + E KK LE +LL QE+ V
Sbjct: 316 VENSNK---EEIQEKETIIEELNTKIIEEE----KKTLELKDKLTTADKLLGELQEQIVQ 368
Query: 118 GGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLT 177
+ I+ +KL + +SK +++EE K L T +++Q+ D S + +
Sbjct: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD-----SQFETDIVQRME 423
Query: 178 EELIKALQDLENAASGDATVRQKIASLPQEV--QDVSLLEKITDKEAAER---------- 225
+E + L+ L A D Q+I + QE+ Q ++ +E++ + E
Sbjct: 424 QETQRKLEQLR--AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
Query: 226 ---------LSKTVDEACLLLAEYNGR-------LAAELEDRRQLARMLV---------- 259
++ ++E + L + N + L LE++ L R L
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
Query: 260 EYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSL 305
E Q + ++E+E KL E + L+ V ++ E+ S +S +L L
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELEL 587
Score = 31.2 bits (69), Expect = 1.3
Identities = 37/190 (19%), Positives = 82/190 (43%), Gaps = 17/190 (8%)
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEE---DDDYPGSYSPQDPSAGPLLTE 178
+QQ + +++ + TE+ + L+ FQQ+Q E + + + + + +LT
Sbjct: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
Query: 179 ELIKALQD--LENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLL 236
+ QD LE+ +I+ L ++++ + E DK+ + + E +
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK---VYEMEQDKKVENSNKEEIQEKETI 330
Query: 237 LAEYNGRL------AAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVR 290
+ E N ++ EL+D+ A L+ Q Q + +K ++++ K +L Q
Sbjct: 331 IEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKE 387
Query: 291 KELKSHIQSL 300
++ I+ L
Sbjct: 388 RQSSEEIKQL 397
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 47.0 bits (110), Expect = 2e-05
Identities = 63/286 (22%), Positives = 121/286 (42%), Gaps = 61/286 (21%)
Query: 67 IQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLE---------RLLNIWQERSVY 117
++NS + E +E E+++ + + + E KK LE +LL QE+ V
Sbjct: 316 VENSNK---EEIQEKETIIEELNTKIIEEE----KKTLELKDKLTTADKLLGELQEQIVQ 368
Query: 118 GGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLT 177
+ I+ +KL + +SK +++EE K L T +++Q+ D S + +
Sbjct: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD-----SQFETDIVQRME 423
Query: 178 EELIKALQDLENAASGDATVRQKIASLPQEV--QDVSLLEKITDKEAAER---------- 225
+E + L+ L A D Q+I + QE+ Q ++ +E++ + E
Sbjct: 424 QETQRKLEQLR--AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
Query: 226 ---------LSKTVDEACLLLAEYNGR-------LAAELEDRRQLARMLV---------- 259
++ ++E + L + N + L LE++ L R L
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
Query: 260 EYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSL 305
E Q + ++E+E KL E + L+ V ++ E+ S +S +L L
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELEL 587
Score = 31.2 bits (69), Expect = 1.3
Identities = 37/190 (19%), Positives = 82/190 (43%), Gaps = 17/190 (8%)
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEE---DDDYPGSYSPQDPSAGPLLTE 178
+QQ + +++ + TE+ + L+ FQQ+Q E + + + + + +LT
Sbjct: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
Query: 179 ELIKALQD--LENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLL 236
+ QD LE+ +I+ L ++++ + E DK+ + + E +
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK---VYEMEQDKKVENSNKEEIQEKETI 330
Query: 237 LAEYNGRL------AAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVR 290
+ E N ++ EL+D+ A L+ Q Q + +K ++++ K +L Q
Sbjct: 331 IEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKE 387
Query: 291 KELKSHIQSL 300
++ I+ L
Sbjct: 388 RQSSEEIKQL 397
>gi|33620745 pre-mRNA cleavage complex II protein Pcf11 [Homo
sapiens]
Length = 1555
Score = 46.2 bits (108), Expect = 4e-05
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 10 EKKLSELS-NSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLANDVIQ 68
+ L +L+ NS+ + L++ + A IVS+ + KA S+ KL +YL + +++
Sbjct: 23 QSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVK 82
Query: 69 NSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQE 113
N G E+ F LV F V + DE +K L +L + W E
Sbjct: 83 N---VGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDE 124
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 45.8 bits (107), Expect = 5e-05
Identities = 67/311 (21%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWL----IHHRKHAGPIVSVWHRELRKAKSNRKLTFLY 61
E +EK+ E++ Q+ ++ L + + KH+ +E + N++ L
Sbjct: 516 ELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLE 575
Query: 62 LANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEF 121
D I + K E ++ E L + +A A+E KK LE +++ QE +
Sbjct: 576 SRLDEILSRIAKETEEIKDLEEQLTEG--QIA--ANEALKKDLEGVISGLQE-------Y 624
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELI 181
+ +K +++ K +EK++L + ++++E D + E +
Sbjct: 625 LGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERD----------QLEIVAMDAENMR 674
Query: 182 KALQDLENAASGDATVRQKIASLPQEVQDVSLLE-------KITDKEAAERLSKTVDEAC 234
K L +LE+A V ASL Q D+S E + D E A +L + +++
Sbjct: 675 KELAELESALQEQHEVN---ASLQQTQGDLSAYEAELEARLNLRDAE-ANQLKEELEKVT 730
Query: 235 LLLAEYNGRLAAELEDRRQLARMLV---EYTQNQKDVLSEKEKKLEEYKQKLARVTQVRK 291
L L AELE RQ + + ++++ ++ SE KL+ + + Q K
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLK 790
Query: 292 ELKSHIQSLPD 302
+ ++H+ + D
Sbjct: 791 DFQNHLNHVVD 801
Score = 30.4 bits (67), Expect = 2.2
Identities = 41/198 (20%), Positives = 76/198 (38%), Gaps = 34/198 (17%)
Query: 125 LKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKAL 184
L+L ME K +E K L+ + + D S+ S + + K
Sbjct: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK---DPKHSHMKAQKSGKEQQLDIMNKQY 571
Query: 185 QDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAA--ERLSKTVDEACLLLAEYNG 242
Q LE+ + +IA +E++D+ E++T+ + A E L K ++ L EY G
Sbjct: 572 QQLESRLD---EILSRIAKETEEIKDLE--EQLTEGQIAANEALKKDLEGVISGLQEYLG 626
Query: 243 RLAA------------------------ELEDRRQLARMLVEYTQNQKDVLSEKEKKLEE 278
+ E+E R ++ +N + L+E E L+E
Sbjct: 627 TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQE 686
Query: 279 YKQKLARVTQVRKELKSH 296
+ A + Q + +L ++
Sbjct: 687 QHEVNASLQQTQGDLSAY 704
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 15/117 (12%)
Query: 176 LTEELIKALQDL----ENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVD 231
L ++L K +DL +NA S ++ QKI +E Q+ + +R +T+D
Sbjct: 360 LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE--------ELSRQQRSFQTLD 411
Query: 232 EACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQ 288
+ C+ + RL EL+ + + +L V + E LEE+KQKL R Q
Sbjct: 412 QECI---QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
Score = 33.9 bits (76), Expect = 0.20
Identities = 52/256 (20%), Positives = 100/256 (39%), Gaps = 12/256 (4%)
Query: 32 HHRKHAGPIVSVWHRELRKAKSNRKLTFLYLANDV--IQNSKRKGPEFTREFESVLVDAF 89
HH V REL A++N++ L N ++ K K T+ + +D
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
Query: 90 SHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRT 149
+ R E L++ E + F L+ ++ K++ + L+
Sbjct: 2389 T--IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 150 FQQIQEEE---DDDYPGSYSPQDPSAGPLLTEELIKA--LQDLENAASGDATVRQKIASL 204
+++ E +D + + + + EL KA LQ L+ A + ++ + L
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Query: 205 PQEVQDVSLLEKITDKEAAERLSKTVDEACLL--LAEYNGRLAAELEDRRQLARMLVEYT 262
QEV+D + D+E + ++ D+ L+ L++ G E +L + VE
Sbjct: 2507 IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 263 QNQKDVLSEKEKKLEE 278
Q + VL K L++
Sbjct: 2567 Q-KIQVLQSKNASLQD 2581
Score = 29.3 bits (64), Expect = 5.0
Identities = 22/91 (24%), Positives = 49/91 (53%), Gaps = 1/91 (1%)
Query: 206 QEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDR-RQLARMLVEYTQN 264
+E ++ SL +K+ + E ++S+ E +L AE + L+ + ++AR L + +
Sbjct: 2145 RERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD 2204
Query: 265 QKDVLSEKEKKLEEYKQKLARVTQVRKELKS 295
+ SEKE ++ ++K +++++ K L S
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
Score = 28.9 bits (63), Expect = 6.5
Identities = 32/161 (19%), Positives = 70/161 (43%), Gaps = 6/161 (3%)
Query: 138 KATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPL--LTEELIKALQDLENAASGDA 195
K T ++ L+R ++ ++ + ++ AG L L EE+ + L+ ++
Sbjct: 2613 KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS 2672
Query: 196 TVRQKIASL--PQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQ 253
+++ + + Q ++ + E+I + + RL + + LL + N + E++ R+
Sbjct: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQL--RLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 254 LARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELK 294
E +QK + + EE L TQ+ +ELK
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 43.1 bits (100), Expect = 3e-04
Identities = 44/167 (26%), Positives = 77/167 (46%), Gaps = 14/167 (8%)
Query: 138 KATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTE--ELIKALQDLENAASGDA 195
++ E + L+R+F +QEE+ D S + S +++ + ALQ+ A
Sbjct: 2578 ESEEANEDLRRSFNALQEEKQD-----LSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 196 TVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTV---DEACLLLAEYNGRLAAELEDRR 252
++ K +EV +S L + K AE + V EA + E +L EL+
Sbjct: 2633 QLKVK----EEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688
Query: 253 QLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQS 299
A ++ T+ ++ ++E + L E +QKL VT+ K L + IQS
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
Score = 38.5 bits (88), Expect = 0.008
Identities = 36/215 (16%), Positives = 89/215 (41%), Gaps = 6/215 (2%)
Query: 86 VDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKS 145
V A V E+ + + E L + R E + K+ ++D++S + +
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE-LASFKVLLDDTQSEAARVLADNLK 2100
Query: 146 LKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLP 205
LK+ Q +E +D L + K L++ +N +R++ L
Sbjct: 2101 LKKELQSNKES----VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
Query: 206 QEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQ 265
+ + ++ + DKE ++L + +D LA + +++ +DR ++ ++ +
Sbjct: 2157 ETIGEIQVTLNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF 2215
Query: 266 KDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
D + KE+++ + + + +++ H++ L
Sbjct: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Score = 38.1 bits (87), Expect = 0.011
Identities = 59/315 (18%), Positives = 122/315 (38%), Gaps = 37/315 (11%)
Query: 3 SFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYL 62
S E+AL K +E+ + ++ L L K + EL + K
Sbjct: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP------- 1468
Query: 63 ANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFI 122
+ I R + R+ ++ L+ K+ L+ ++ +E S+ G I
Sbjct: 1469 --EEIGEESRAKQQIQRKLQAALISR------------KEALKENKSLQEELSLARGT-I 1513
Query: 123 QQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEED------------DDYPGSYSPQDP 170
++L S+ D +S +EK ++ +QEE D + S
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573
Query: 171 SAGPLLTEE---LIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLS 227
A LTE+ L+K ++ L+++ ++T Q+ Q+ ++ L AER+
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633
Query: 228 KTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVT 287
V+ E G+L + ++++ + L E Q +++ + K + +QK+ +
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Query: 288 QVRKELKSHIQSLPD 302
+ L++ + D
Sbjct: 1694 EENDRLRAEVHPAGD 1708
Score = 31.2 bits (69), Expect = 1.3
Identities = 38/205 (18%), Positives = 79/205 (38%), Gaps = 11/205 (5%)
Query: 101 KKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEED-- 158
K L L +E GG + S E +TEE+ +++ ++QE+E+
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160
Query: 159 ---DDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLE 215
+ P+ EE + Q L+ +T++ A L Q + + +
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ---AQLSQTQAEQAAQQ 217
Query: 216 KITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKK 275
+ +K+A + E LL + E++ Q R+L + ++ L + +
Sbjct: 218 VVREKDARFETQVRLHEDELLQLVTQADVETEMQ---QKLRVLQRKLEEHEESLVGRAQV 274
Query: 276 LEEYKQKLARVTQVRKELKSHIQSL 300
++ +Q+L Q + L +Q +
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQM 299
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
[Homo sapiens]
Length = 1235
Score = 42.4 bits (98), Expect = 6e-04
Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 31/208 (14%)
Query: 102 KPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDY 161
K +E LLN Q+R Y +K + E++ K KKS+K + +Q ++EDD
Sbjct: 285 KSVETLLN--QKRPQY-------IK-AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIK 334
Query: 162 PGSYSPQDPSAG-----PLLTEELIKALQDLENAASG-------DATVRQKIASLPQEVQ 209
D A + EE++ +D+E AS VR+K+A++ Q+++
Sbjct: 335 ALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLE 394
Query: 210 DVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVL 269
+ +K TD+E + E L + + ++ED ++ L EYT+ D L
Sbjct: 395 KLQWEQK-TDEERLAFEKRRHGEVQGNLKQ----IKEQIEDHKKRIEKLEEYTKTCMDCL 449
Query: 270 SEKEKK----LEEYKQKLARVTQVRKEL 293
EK+++ ++E ++ +R+++ +EL
Sbjct: 450 KEKKQQEETLVDEIEKTKSRMSEFNEEL 477
>gi|62460633 RNA-binding motif protein 16 [Homo sapiens]
Length = 1271
Score = 42.0 bits (97), Expect = 7e-04
Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 7/105 (6%)
Query: 40 IVSVWHRELRKAKSNRKLTFLYLANDVIQNSKRK-GPE---FTREFESVLVDAFSHVARE 95
+V + ++K K K+ LY+ + +++ S+ + G E F F + ++ F ++ R
Sbjct: 43 VVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRC 102
Query: 96 ADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKAT 140
+ K + R+LN+WQ+ +V+ E IQ L L M + PPP T
Sbjct: 103 PGDD-KSKIVRVLNLWQKNNVFKSEIIQPL-LDMA-AGIPPPVVT 144
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 42.0 bits (97), Expect = 7e-04
Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 23/185 (12%)
Query: 123 QQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEE---EDDDY--PGSYSPQDPSAGPLLT 177
Q+ K D PP++ K+S K+ ++ EE ED++ P S +P P +
Sbjct: 430 QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVV 489
Query: 178 EELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLL 237
L L ++ R ++ P S+++ + R+ D C +
Sbjct: 490 RPLRTFLHTVQ---------RNQMLMTPTSAPR-SVMKSFIKRNTPLRM----DPKCSFV 535
Query: 238 AEYNGRL--AAELEDRRQLARMLVEYTQNQK--DVLSEKEKKLEEYKQKLARVTQVRKEL 293
+ RL E+ QL R VE + ++ +V ++E++L + Q RV Q+++E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 294 KSHIQ 298
K I+
Sbjct: 596 KKQIE 600
Score = 29.3 bits (64), Expect = 5.0
Identities = 60/272 (22%), Positives = 106/272 (38%), Gaps = 52/272 (19%)
Query: 56 KLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERS 115
K +F+ ++N +RK + V D R +E K ERL + Q R
Sbjct: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDK----RRRLEEVKLKREERLRKVLQAR- 585
Query: 116 VYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPL 175
E ++Q+K E+KK +++ F QI E+ + + +
Sbjct: 586 ----ERVEQMK-------------EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK--- 625
Query: 176 LTEELIKALQDLENAASGDATVRQKIASLPQEVQD---VSLLEKITDKEAAERLSKTVDE 232
+ K ++++E + R ++ L QE ++ LL+K ++E ERL K +
Sbjct: 626 --KAAAKKMEEVEARRKQEEEAR-RLRWLQQEEEERRHQELLQKKKEEEQ-ERLRKAAEA 681
Query: 233 ACLLLAEYNGRLAAEL------------EDRRQLARMLVEYTQNQKD-------VLSEKE 273
L R E ++RR+ R L E + ++ L E+E
Sbjct: 682 KRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQERE 741
Query: 274 KKLEEYKQKLARVTQVRKELKSHIQSLPDLSL 305
K L K++L R + +K+ K Q L + L
Sbjct: 742 KALRLQKEQLQRELEEKKK-KEEQQRLAERQL 772
>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
Length = 1194
Score = 41.6 bits (96), Expect = 0.001
Identities = 73/315 (23%), Positives = 131/315 (41%), Gaps = 54/315 (17%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLAND 65
E ALE++ +E+ ++ + L + + G HREL KA+ AN
Sbjct: 239 EEALERQRAEVCQLRERLAVLCRQMSQLEEELGTA----HRELGKAEE---------ANS 285
Query: 66 VIQNSKRKGPEFTREFE---SVLVDAFSHVAREADEGCKKPLERLLN-IWQERSVYGGEF 121
+Q ++ + E + L + REA ++L N + + S+Y
Sbjct: 286 KLQRDLKEALAQREDMEERITTLEKRYLSAQREATS-LHDANDKLENELASKESLY---- 340
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELI 181
+ S E S+ + K+ L++T Q+ + P L + +
Sbjct: 341 ----RQSEEKSRQLAEWLDDAKQKLQQTLQKAETL-------------PEIEAQLAQRVA 383
Query: 182 KALQDLENAASGDATVRQKIASLP---QEVQDVSLLEKITDKEAAERLSKTVDEACLLLA 238
+ E + + +RQ A L QE+Q EK+ D + +RLS+TVD+ LL+
Sbjct: 384 ALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMND-DHNKRLSETVDK---LLS 439
Query: 239 EYNGRLAAEL-------EDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVR- 290
E N RL L E++ L+ + + Q ++L KE+ L E ++ + Q+R
Sbjct: 440 ESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRG 499
Query: 291 KELKSHIQSLPDLSL 305
+ S+ +SLP +L
Sbjct: 500 RPPSSYSRSLPGSAL 514
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 41.6 bits (96), Expect = 0.001
Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 37/257 (14%)
Query: 107 LLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYS 166
L + QE+S ++ K +D + KA EE+ L+ + +QE+ + +
Sbjct: 172 LATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLIT 231
Query: 167 -----PQDPSAGPLLTEELIKAL-------QDLE-------NAASGDATVRQKI------ 201
Q+ S L+ EL K L QDLE A +G A +++
Sbjct: 232 QQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQ 291
Query: 202 -ASLPQEVQDV-SLLEKITDK--EAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARM 257
L +EV+++ S L+ I D+ + RL + +EA L + + +L E+
Sbjct: 292 TKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQ 351
Query: 258 LVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSL---LPNVTGGLA 314
L + +Q ++ ++ E ++ E + L + +++ + IQ L + L L N T LA
Sbjct: 352 LRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALA 411
Query: 315 -----PLPSAGDLFSTD 326
PL S G+ S D
Sbjct: 412 ASSRSPLDSHGEESSLD 428
Score = 30.4 bits (67), Expect = 2.2
Identities = 29/116 (25%), Positives = 57/116 (49%), Gaps = 10/116 (8%)
Query: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
++ L DLE S +A +K +L + Q++ L KE ER
Sbjct: 456 VEKLCDLEIMPSSEAADGEKATALYYQ-QELKQL-----KEEFERYKMRAQVVLKSKNTK 509
Query: 241 NGRLAAELED-RRQLARMLVEYTQNQ---KDVLSEKEKKLEEYKQKLARVTQVRKE 292
+G L ELE + QLA + +Y + +++ + +++ +++KQ+LAR+ Q+ ++
Sbjct: 510 DGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQ 565
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 41.2 bits (95), Expect = 0.001
Identities = 58/302 (19%), Positives = 117/302 (38%), Gaps = 60/302 (19%)
Query: 1 MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL 60
MS + S L K EL ++ V+ L L L ++A + KA+ ++
Sbjct: 890 MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ----- 944
Query: 61 YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE 120
Q + +K E +E E L D + ++ C++ R E E
Sbjct: 945 -------QEAAKKHEEEKKELERKLSDLEKKMETSHNQ-CQELKARYERATSETKTKHEE 996
Query: 121 FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL 180
+Q L+ ++ D++ A EE L + ++++++ D
Sbjct: 997 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK--------------------- 1035
Query: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
KA Q E+A + ++E++T KE E L+ D +
Sbjct: 1036 AKAAQTAEDA--------------------MQIMEQMT-KEKTETLASLEDTK-----QT 1069
Query: 241 NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
N +L EL+ ++ VE K++L+ + +K+EE+++++ + Q + + +L
Sbjct: 1070 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1129
Query: 301 PD 302
+
Sbjct: 1130 QE 1131
Score = 37.4 bits (85), Expect = 0.018
Identities = 43/198 (21%), Positives = 84/198 (42%), Gaps = 13/198 (6%)
Query: 101 KKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDD 160
K+ LE+ L I +E+ E ++ SM+++ + + E+ L ++++E D
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL-AD 858
Query: 161 YPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDK 220
+ +D E+LIKA + LEN + + +S ++ D L++ +
Sbjct: 859 MEAKFREKDER-----EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 913
Query: 221 EAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLE--- 277
E +L+K + A L + +++ A+ E + + LS+ EKK+E
Sbjct: 914 ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 973
Query: 278 ----EYKQKLARVTQVRK 291
E K + R T K
Sbjct: 974 NQCQELKARYERATSETK 991
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 41.2 bits (95), Expect = 0.001
Identities = 58/302 (19%), Positives = 117/302 (38%), Gaps = 60/302 (19%)
Query: 1 MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFL 60
MS + S L K EL ++ V+ L L L ++A + KA+ ++
Sbjct: 925 MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ----- 979
Query: 61 YLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGE 120
Q + +K E +E E L D + ++ C++ R E E
Sbjct: 980 -------QEAAKKHEEEKKELERKLSDLEKKMETSHNQ-CQELKARYERATSETKTKHEE 1031
Query: 121 FIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEEL 180
+Q L+ ++ D++ A EE L + ++++++ D
Sbjct: 1032 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK--------------------- 1070
Query: 181 IKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
KA Q E+A + ++E++T KE E L+ D +
Sbjct: 1071 AKAAQTAEDA--------------------MQIMEQMT-KEKTETLASLEDTK-----QT 1104
Query: 241 NGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
N +L EL+ ++ VE K++L+ + +K+EE+++++ + Q + + +L
Sbjct: 1105 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1164
Query: 301 PD 302
+
Sbjct: 1165 QE 1166
Score = 37.4 bits (85), Expect = 0.018
Identities = 43/198 (21%), Positives = 84/198 (42%), Gaps = 13/198 (6%)
Query: 101 KKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDD 160
K+ LE+ L I +E+ E ++ SM+++ + + E+ L ++++E D
Sbjct: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL-AD 893
Query: 161 YPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDK 220
+ +D E+LIKA + LEN + + +S ++ D L++ +
Sbjct: 894 MEAKFREKDER-----EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 948
Query: 221 EAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLE--- 277
E +L+K + A L + +++ A+ E + + LS+ EKK+E
Sbjct: 949 ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008
Query: 278 ----EYKQKLARVTQVRK 291
E K + R T K
Sbjct: 1009 NQCQELKARYERATSETK 1026
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 41.2 bits (95), Expect = 0.001
Identities = 74/348 (21%), Positives = 141/348 (40%), Gaps = 70/348 (20%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLAND 65
+ L +KL E S ++ ++ L + + R H G + +E+ + + L L N
Sbjct: 915 QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Query: 66 VIQ---NSKRKGPEFTREFESVLVDAF-SHVAREADEGCKKPLERLLNIWQ--------- 112
+ + ++R+ E R+ + ++A S + + + +E L +Q
Sbjct: 975 LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTK 1034
Query: 113 ----ERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQ 168
E+++ E+ + K ++D +S K E+K S Q++ E +++ S
Sbjct: 1035 RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS------QLEMELEEERNNS---- 1084
Query: 169 DPSAGPLLTEELIKA---LQDLENAASGDATVRQKIA--SLPQEVQDVSLLEKITDKEAA 223
LL+E + ++ ++ L N + RQ + + E Q+ L +I E +
Sbjct: 1085 -----DLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
Query: 224 ERLSKT--VDEACLLLAEYNGRLAAELEDR-------RQLARMLVEYTQ----------N 264
R SK V + +AE RL +E DR R+L R + E +
Sbjct: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Query: 265 QKDVLS--------------EKEKKLEEYKQKLARVTQVRKELKSHIQ 298
QKD LS E+ +LE K+KL R + + ++ H+Q
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
Score = 38.1 bits (87), Expect = 0.011
Identities = 59/296 (19%), Positives = 116/296 (39%), Gaps = 52/296 (17%)
Query: 11 KKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSV---WHRELRKAKSNRKLTFLYLANDVI 67
K L + ++ L L+H RK VS EL A+ N T
Sbjct: 861 KAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT--------T 912
Query: 68 QNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKL 127
Q K+ + E E K+ L RL N + + G+ I++L+
Sbjct: 913 QEQKQLSEKLKEESEQ-----------------KEQLRRLKNEMENERWHLGKTIEKLQK 955
Query: 128 SMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDL 187
M D +T E +Q + D+ Y ++ + +L + +
Sbjct: 956 EMADIVEASRTSTLE----------LQNQLDE-----YKEKNRRELAEMQRQLKEKTLEA 1000
Query: 188 ENAASGDATVRQKIASLPQEVQDVSLL--EKITDKEAAERLSKTVD---EACLLLAEYNG 242
E + ++ ++ + +E++D E +T ++ E+ K ++ EA L +
Sbjct: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
Query: 243 RLAAELEDRRQLARMLVEYTQNQKDVLSEK----EKKLEEYKQKLARVTQVRKELK 294
RL ++ED+ M +E +N D+LSE+ +++E+ + +L + R++L+
Sbjct: 1061 RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 32.3 bits (72), Expect = 0.59
Identities = 31/173 (17%), Positives = 77/173 (44%), Gaps = 15/173 (8%)
Query: 128 SMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDL 187
S ++++ P +++ ++T ++ ++ +Y S + A + + +Q L
Sbjct: 529 SASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTL 588
Query: 188 ENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAE 247
++ A+G A + + EV+D+ E+ SK E +AE +L E
Sbjct: 589 KSRAAGSAQGNNQACNSTSEVKDL-----------LEQKSKLTIE----VAELQRQLQLE 633
Query: 248 LEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
+++++ + N +++ S+ +K+EE R+ + EL+ +++ L
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEEL 686
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 40.0 bits (92), Expect = 0.003
Identities = 31/133 (23%), Positives = 66/133 (49%), Gaps = 6/133 (4%)
Query: 170 PSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKT 229
PS LLTE + + + + +++K + Q + + L E+ +A + +
Sbjct: 334 PSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDL-ERAEVAKATSHICEV 392
Query: 230 VDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQK----DVLSEKEKKLEEYKQKLAR 285
E LL A++ + AE E++ Q AR+LVE + +K + L E+ +K+E+ + ++
Sbjct: 393 EKEIALLKAQHE-QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
Query: 286 VTQVRKELKSHIQ 298
+ + +L++ Q
Sbjct: 452 ESITKGDLETQTQ 464
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 40.0 bits (92), Expect = 0.003
Identities = 38/188 (20%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELI 181
++ L L +E S + +++++ + + +++ ++ + Q S L+ EL
Sbjct: 1428 VEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS--LSTELF 1485
Query: 182 KALQDLENAASGDATVRQKIASLPQEVQDVS--LLEKITDKEAAERLSKTVD-EACLLLA 238
K E + T+R++ +L QE+ D++ + E E++ K V+ E C + A
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545
Query: 239 EYNGRLAAELEDRRQLARMLVEYTQNQKDV---LSEKEKKLEEYKQKLARVTQ-VRKELK 294
A+ + ++ R+ +E Q + +V ++EK++++++ K+ RV + ++ L
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Query: 295 SHIQSLPD 302
+ I+S D
Sbjct: 1606 AEIRSRND 1613
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 40.0 bits (92), Expect = 0.003
Identities = 50/243 (20%), Positives = 95/243 (39%), Gaps = 24/243 (9%)
Query: 63 ANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFI 122
A + + KR+ + + ES+ + H+ R +E K ER+ + R E
Sbjct: 411 AEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELS 470
Query: 123 QQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIK 182
+ ++ + + + K + QQ +D +D + G L ++ +
Sbjct: 471 RVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV 530
Query: 183 ALQDLENAASGDAT--VRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEY 240
A + G +R+++ L QE+ + D+E +S+ E L E
Sbjct: 531 AEAQTRVSQLGLQVEGLRRRLEELQQELS-------LKDQERVAEVSRVRVE----LQEQ 579
Query: 241 NGRLAAEL-------EDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKL----ARVTQV 289
NGRL AEL E L R L + ++ L ++E + ++KL A + ++
Sbjct: 580 NGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARI 639
Query: 290 RKE 292
R E
Sbjct: 640 RDE 642
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 39.7 bits (91), Expect = 0.004
Identities = 49/212 (23%), Positives = 90/212 (42%), Gaps = 13/212 (6%)
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEE---EDDDYPGSYSPQDPSAGPLL-T 177
+Q LKL E++ +A +KK+ + +Q++EE G+ D + L
Sbjct: 8 MQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDA 67
Query: 178 EELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLL 237
+E ++ + + A GD + L +E D + T + E K DE+ +
Sbjct: 68 QEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGM 127
Query: 238 AEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARV--TQVRKELKS 295
R A + E++ ++ M + + K + E ++K EE +KL + R E ++
Sbjct: 128 KVIENR-AMKDEEKMEIQEMQL---KEAKHIAEEADRKYEEVARKLVILEGELERAEERA 183
Query: 296 HIQSLPDLSL---LPNVTGGLAPLPSAGDLFS 324
+ L L L NVT L L +A + +S
Sbjct: 184 EVSELKCGDLEEELKNVTNNLKSLEAASEKYS 215
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 39.7 bits (91), Expect = 0.004
Identities = 42/196 (21%), Positives = 88/196 (44%), Gaps = 26/196 (13%)
Query: 120 EFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLL--- 176
E IQQL+ +E ++ + L+ ++ E D+ SA LL
Sbjct: 1261 EEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDE-----RNTGESASQLLDAE 1315
Query: 177 TEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLE------KITDKEAA------- 223
T E ++A ++++ + +++++ + EV + L+ ++ D +A
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKY 1375
Query: 224 ERLSKTVD-EACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQK 282
ER + VD L E+ +L E +++RQL R L + + + E ++ L++ K+K
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSE----ESQRALQQLKKK 1431
Query: 283 LARVTQVRKELKSHIQ 298
R+T ++ K H++
Sbjct: 1432 CQRLTAELQDTKLHLE 1447
Score = 39.3 bits (90), Expect = 0.005
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 45/253 (17%)
Query: 79 REFESVLVD--AFSHVAREADEGCKKPLERLLNIWQERSVY-GGEFIQQLKLSMEDSK-- 133
R+ E L D A S ++ A + KK +RL Q+ ++ G+ ++ +L + +
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFD 1464
Query: 134 SPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASG 193
S +A EE + K +++Q E+D +L E Q LE
Sbjct: 1465 SELSQAHEEAQREKLQREKLQREKD----------------MLLAEAFSLKQQLEEKDMD 1508
Query: 194 DATVRQKIASLPQEVQDVSLLE------------KITDKEA-AERLSKTVDE---ACLLL 237
A QK+ SL E+QD+S E ++ D EA + + +DE +L
Sbjct: 1509 IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQML 1568
Query: 238 AEYNGRLAAELEDRRQL--------ARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQV 289
+ RL E+E RQ + E Q+ + L + E +LEE + +V +
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE 1628
Query: 290 RKELKSHIQSLPD 302
++EL+ + +L D
Sbjct: 1629 KRELEGKLATLSD 1641
Score = 33.5 bits (75), Expect = 0.26
Identities = 59/321 (18%), Positives = 131/321 (40%), Gaps = 42/321 (13%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSN--RKLTFLYLA 63
E L+++ + +Q+ L + + R+ + E+ +A+ + +KL + +
Sbjct: 1555 EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQ 1614
Query: 64 NDVIQNSKRKGPEFTREFESVLVDAFSHVAR---EADEGCKKPLER---------LLNIW 111
+ K+K RE E L V R E+++ +K L+R L+
Sbjct: 1615 LEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDH 1674
Query: 112 QERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPS 171
+ S I QLK +E+S+ A + +K+++ + + + D D +
Sbjct: 1675 LKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID----------DIA 1724
Query: 172 AGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVD 231
EE + LQ +N ++ ++ +++ ++ K +A+ L++ D
Sbjct: 1725 KAKTALEEQLSRLQREKN------EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIND 1778
Query: 232 EACLLLAEYNGRLAAELEDRRQLARMLVEYTQN---QKDVLSEKEKKLEEYKQKL----- 283
L E + EL+++ Q + VE+ + K ++S +E K+ E + +L
Sbjct: 1779 LQAQL--EEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERT 1836
Query: 284 --ARVTQVRKELKSHIQSLPD 302
R+ + LK +++ L +
Sbjct: 1837 QVKRLESLASRLKENMEKLTE 1857
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 39.7 bits (91), Expect = 0.004
Identities = 42/196 (21%), Positives = 88/196 (44%), Gaps = 26/196 (13%)
Query: 120 EFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLL--- 176
E IQQL+ +E ++ + L+ ++ E D+ SA LL
Sbjct: 1261 EEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDE-----RNTGESASQLLDAE 1315
Query: 177 TEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLE------KITDKEAA------- 223
T E ++A ++++ + +++++ + EV + L+ ++ D +A
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKY 1375
Query: 224 ERLSKTVD-EACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQK 282
ER + VD L E+ +L E +++RQL R L + + + E ++ L++ K+K
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSE----ESQRALQQLKKK 1431
Query: 283 LARVTQVRKELKSHIQ 298
R+T ++ K H++
Sbjct: 1432 CQRLTAELQDTKLHLE 1447
Score = 39.3 bits (90), Expect = 0.005
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 45/253 (17%)
Query: 79 REFESVLVD--AFSHVAREADEGCKKPLERLLNIWQERSVY-GGEFIQQLKLSMEDSK-- 133
R+ E L D A S ++ A + KK +RL Q+ ++ G+ ++ +L + +
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFD 1464
Query: 134 SPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASG 193
S +A EE + K +++Q E+D +L E Q LE
Sbjct: 1465 SELSQAHEEAQREKLQREKLQREKD----------------MLLAEAFSLKQQLEEKDMD 1508
Query: 194 DATVRQKIASLPQEVQDVSLLE------------KITDKEA-AERLSKTVDE---ACLLL 237
A QK+ SL E+QD+S E ++ D EA + + +DE +L
Sbjct: 1509 IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQML 1568
Query: 238 AEYNGRLAAELEDRRQL--------ARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQV 289
+ RL E+E RQ + E Q+ + L + E +LEE + +V +
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE 1628
Query: 290 RKELKSHIQSLPD 302
++EL+ + +L D
Sbjct: 1629 KRELEGKLATLSD 1641
Score = 33.5 bits (75), Expect = 0.26
Identities = 59/321 (18%), Positives = 131/321 (40%), Gaps = 42/321 (13%)
Query: 6 ESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSN--RKLTFLYLA 63
E L+++ + +Q+ L + + R+ + E+ +A+ + +KL + +
Sbjct: 1555 EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQ 1614
Query: 64 NDVIQNSKRKGPEFTREFESVLVDAFSHVAR---EADEGCKKPLER---------LLNIW 111
+ K+K RE E L V R E+++ +K L+R L+
Sbjct: 1615 LEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDH 1674
Query: 112 QERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPS 171
+ S I QLK +E+S+ A + +K+++ + + + D D +
Sbjct: 1675 LKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID----------DIA 1724
Query: 172 AGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVD 231
EE + LQ +N ++ ++ +++ ++ K +A+ L++ D
Sbjct: 1725 KAKTALEEQLSRLQREKN------EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIND 1778
Query: 232 EACLLLAEYNGRLAAELEDRRQLARMLVEYTQN---QKDVLSEKEKKLEEYKQKL----- 283
L E + EL+++ Q + VE+ + K ++S +E K+ E + +L
Sbjct: 1779 LQAQL--EEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERT 1836
Query: 284 --ARVTQVRKELKSHIQSLPD 302
R+ + LK +++ L +
Sbjct: 1837 QVKRLESLASRLKENMEKLTE 1857
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 39.7 bits (91), Expect = 0.004
Identities = 44/189 (23%), Positives = 81/189 (42%), Gaps = 25/189 (13%)
Query: 123 QQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEE---EDDDY--PGSYSPQDPSAGPLLT 177
Q+ K D PP++ K+S K+ ++ EE ED++ P S +P P +
Sbjct: 430 QEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVV 489
Query: 178 EEL------IKALQDLENAASGDATV------RQKIASLPQEVQDVSLLEKITDKEAAER 225
L ++ Q L S +V R + + ++ LE + KE AE+
Sbjct: 490 RPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQ 549
Query: 226 LSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLAR 285
L + E E R E++ +R+ L + Q ++ V KE+K ++ +QK A+
Sbjct: 550 LRRQKVE------EDKRRRLEEVKLKRE--ERLRKVLQARERVEQMKEEKKKQIEQKFAQ 601
Query: 286 VTQVRKELK 294
+ + ++ K
Sbjct: 602 IDEKTEKAK 610
Score = 28.9 bits (63), Expect = 6.5
Identities = 53/234 (22%), Positives = 93/234 (39%), Gaps = 48/234 (20%)
Query: 94 READEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQI 153
R +E K ERL + Q R E ++Q+K E+KK +++ F QI
Sbjct: 561 RRLEEVKLKREERLRKVLQAR-----ERVEQMK-------------EEKKKQIEQKFAQI 602
Query: 154 QEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQD--- 210
E+ + + + + K ++++E + R ++ L QE ++
Sbjct: 603 DEKTEKAKEERLAEEKAKK-----KAAAKKMEEVEARRKQEEEAR-RLRWLQQEEEERRH 656
Query: 211 VSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAEL------------EDRRQLARML 258
LL+K ++E ERL K + L R E ++RR+ R L
Sbjct: 657 QELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
Query: 259 VEYTQNQKD-------VLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSL 305
E + ++ L E+EK L K++L R + +K+ K Q L + L
Sbjct: 716 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK-KEEQQRLAERQL 768
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 39.3 bits (90), Expect = 0.005
Identities = 54/252 (21%), Positives = 99/252 (39%), Gaps = 32/252 (12%)
Query: 62 LANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEF 121
LA + + +GP R+ ++ F + RE EG K +L+N + E+ +
Sbjct: 235 LATQLELDGFERGPFSERQIKN-----FHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 289
Query: 122 IQQLKLS-------MEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGP 174
I +++ +E K E K++K QQ++ D
Sbjct: 290 IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILE------------ 337
Query: 175 LLTEELIKALQDLENAA--SGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDE 232
L +ELIKA ++L A S T++ ++ SL E D+ + D+E + T
Sbjct: 338 -LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 396
Query: 233 ACLLL-----AEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVT 287
+ + A+ + ++ L+ Y N+K + K +E Q R+
Sbjct: 397 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
Query: 288 QVRKELKSHIQS 299
++ KEL S Q+
Sbjct: 457 KLNKELASSEQN 468
Score = 30.0 bits (66), Expect = 2.9
Identities = 43/223 (19%), Positives = 95/223 (42%), Gaps = 57/223 (25%)
Query: 137 PKATEEKKSLKRTFQQIQE--EEDDDYPGSYSPQDPSAGPLLTEELIKA-----LQDLEN 189
P+ + +++ R Q+++ EE + G+ P++ SA LT+ I L+D+E
Sbjct: 609 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 668
Query: 190 AASGDA---------------------------TVRQKIASLPQEVQD----VSLLEKIT 218
+ A TV KI + +QD + L+ T
Sbjct: 669 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 728
Query: 219 DKEAAERLS--------KTVDEACLLLAEYNGRLAAELEDRRQ----LARMLVEYTQNQK 266
++ +E+L + ++E + L+ L E++D ++ L L ++ Q ++
Sbjct: 729 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 788
Query: 267 DVLSEK-------EKKLEEYKQKLARVTQVRKELKSHIQSLPD 302
+++++K + KL + K+K+ + K+++++IQ D
Sbjct: 789 ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD 831
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 39.3 bits (90), Expect = 0.005
Identities = 54/252 (21%), Positives = 99/252 (39%), Gaps = 32/252 (12%)
Query: 62 LANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEF 121
LA + + +GP R+ ++ F + RE EG K +L+N + E+ +
Sbjct: 374 LATQLELDGFERGPFSERQIKN-----FHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 428
Query: 122 IQQLKLS-------MEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGP 174
I +++ +E K E K++K QQ++ D
Sbjct: 429 IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILE------------ 476
Query: 175 LLTEELIKALQDLENAA--SGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDE 232
L +ELIKA ++L A S T++ ++ SL E D+ + D+E + T
Sbjct: 477 -LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 535
Query: 233 ACLLL-----AEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVT 287
+ + A+ + ++ L+ Y N+K + K +E Q R+
Sbjct: 536 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 595
Query: 288 QVRKELKSHIQS 299
++ KEL S Q+
Sbjct: 596 KLNKELASSEQN 607
Score = 30.0 bits (66), Expect = 2.9
Identities = 43/223 (19%), Positives = 95/223 (42%), Gaps = 57/223 (25%)
Query: 137 PKATEEKKSLKRTFQQIQE--EEDDDYPGSYSPQDPSAGPLLTEELIKA-----LQDLEN 189
P+ + +++ R Q+++ EE + G+ P++ SA LT+ I L+D+E
Sbjct: 748 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 807
Query: 190 AASGDA---------------------------TVRQKIASLPQEVQD----VSLLEKIT 218
+ A TV KI + +QD + L+ T
Sbjct: 808 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 867
Query: 219 DKEAAERLS--------KTVDEACLLLAEYNGRLAAELEDRRQ----LARMLVEYTQNQK 266
++ +E+L + ++E + L+ L E++D ++ L L ++ Q ++
Sbjct: 868 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 927
Query: 267 DVLSEK-------EKKLEEYKQKLARVTQVRKELKSHIQSLPD 302
+++++K + KL + K+K+ + K+++++IQ D
Sbjct: 928 ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD 970
>gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]
Length = 1019
Score = 39.3 bits (90), Expect = 0.005
Identities = 81/351 (23%), Positives = 135/351 (38%), Gaps = 45/351 (12%)
Query: 5 SESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLAN 64
S+SAL+K L E S Q L+ H G V + EL A + L
Sbjct: 164 SQSALQKLL-EYGGSSLHQQAALHKLLTQSPHIGNSVGGSYLEL--ANTLHSAALASLKG 220
Query: 65 DVIQNSKR-KGPEFTREF-ESVLVDAF---SHVAREADEGCKKPLERLLNIWQERSVYGG 119
D+++ +KR + E R+ E L A SH+ RE ++ ER ++ER
Sbjct: 221 DIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHED----VQERTTLRYEERITELH 276
Query: 120 EFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPL---- 175
I +L ++ + + +E L+ Q Q E ++D Q + P
Sbjct: 277 SVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQST 336
Query: 176 -----------LTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAE 224
L EL + L LEN G ++ SL D + + T E +
Sbjct: 337 MVTADMDNCSDLNSELQRVLTGLENVVCGR---KKSSCSLSVAEVDRHIEQLTTASEHCD 393
Query: 225 RLSKTVDEACLLL--------AEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKL 276
KTV+E +L AE R EL R+ L ++++ L+ + +
Sbjct: 394 LAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATM 453
Query: 277 EEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPL-----PSAGDL 322
+++ R+ + +EL++ +QS+ P+ G L PS G+L
Sbjct: 454 NAIREERDRLRRRVRELQTRLQSVQATG--PSSPGRLTSTNRPINPSTGEL 502
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 39.3 bits (90), Expect = 0.005
Identities = 52/218 (23%), Positives = 103/218 (47%), Gaps = 23/218 (10%)
Query: 90 SHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRT 149
+++A EA E K LE+ + + +Q L+ S D K E K +LK
Sbjct: 437 NNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIK-NLKEE 495
Query: 150 FQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQ 209
++++++ + S+ Q EE Q+L++A ++I +L QE +
Sbjct: 496 IEKLRKQVTES---SHLEQQ-------LEEANAVRQELDDAFRQIKAYEKQIKTLQQERE 545
Query: 210 DVSLLEKITDKEAAERLSKTVDEA-C---LLLAEY---NGRLAAELEDRRQLARMLVEYT 262
D++ E + E + SK + +A C L + E+ N RL +++LAR +
Sbjct: 546 DLNK-ELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLAR----HV 600
Query: 263 QNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSL 300
+++++ + +K+E +Q+L R + +KEL+ H ++L
Sbjct: 601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEAL 638
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 38.9 bits (89), Expect = 0.006
Identities = 57/219 (26%), Positives = 96/219 (43%), Gaps = 27/219 (12%)
Query: 122 IQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEE---EDDDYPGSYSPQDPSAGPLLTE 178
+Q LKL E++ +A E+K + +Q+++E G+ D +E
Sbjct: 9 MQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDK-----YSE 63
Query: 179 ELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVD--EACLL 236
L A + LE A A ++ASL + +Q L+E+ D+ A ERL+ + E
Sbjct: 64 ALKDAQEKLELAEKKAADAEAEVASLNRRIQ---LVEEELDR-AQERLATALQKLEEAEK 119
Query: 237 LAEYNGRLAAELEDRRQLARMLVEYTQNQ----KDVLSEKEKKLEEYKQKLARV------ 286
A+ + R +E+R +E + Q K + E ++K EE +KL +
Sbjct: 120 AADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLER 179
Query: 287 TQVRKEL-KSHIQSLPDLSLLPNVTGGLAPLPSAGDLFS 324
T+ R EL +S L + L NVT L L + + +S
Sbjct: 180 TEERAELAESKCSELEE--ELKNVTNNLKSLEAQAEKYS 216
Score = 33.5 bits (75), Expect = 0.26
Identities = 47/172 (27%), Positives = 68/172 (39%), Gaps = 35/172 (20%)
Query: 124 QLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKA 183
Q KL + + K+ +A E SL R Q ++EE D E L A
Sbjct: 69 QEKLELAEKKAADAEA--EVASLNRRIQLVEEELDR----------------AQERLATA 110
Query: 184 LQDLENA--ASGDATVRQKIASL-------PQEVQDVSLLEKITDKEAAERLSKTVDEAC 234
LQ LE A A+ ++ K+ E+Q++ L E K AE + +E
Sbjct: 111 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA---KHIAEEADRKYEEVA 167
Query: 235 LLLAEYNGRLAAELEDRRQLARM----LVEYTQNQKDVLSEKEKKLEEYKQK 282
L G L E+R +LA L E +N + L E + E+Y QK
Sbjct: 168 RKLVIIEGDLE-RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQK 218
>gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo
sapiens]
Length = 603
Score = 38.5 bits (88), Expect = 0.008
Identities = 59/296 (19%), Positives = 129/296 (43%), Gaps = 38/296 (12%)
Query: 5 SESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHREL--RKAKSNRKLTFLYL 62
+E LE ++ L+ ++ + T ++H KH+ ++L R +S++++ L
Sbjct: 119 AERELEGQIQRLNTEKKKLNTD----LYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEW 174
Query: 63 ANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFI 122
+ + +++K P D FS ++ K+ LE+ + +E+ + G +
Sbjct: 175 SLCAVAATQKKKP-----------DGFSSRSKAL---LKRQLEQSI---REQILLKGH-V 216
Query: 123 QQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIK 182
QLK S+++ + + E+ K + +QQ + + ++ EEL +
Sbjct: 217 TQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEV--CTLKEEKKHDTHRVEELER 274
Query: 183 ALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNG 242
+L L+N + S E+QD L K ++ A E ++ + C+ L
Sbjct: 275 SLSRLKNQMAEPLPPDAPAVSSEVELQD---LRKELERVAGELQAQVENNQCISLLN--- 328
Query: 243 RLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQ 298
+++ R E Q Q++ L E+EK+L++ + + + +++ E KS +Q
Sbjct: 329 ------RGQKERLREQEERLQEQQERLREREKRLQQLAEPQSDLEELKHENKSALQ 378
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,250,499
Number of Sequences: 37866
Number of extensions: 559870
Number of successful extensions: 4086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 390
Number of HSP's that attempted gapping in prelim test: 3402
Number of HSP's gapped (non-prelim): 1006
length of query: 326
length of database: 18,247,518
effective HSP length: 103
effective length of query: 223
effective length of database: 14,347,320
effective search space: 3199452360
effective search space used: 3199452360
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.