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Search of human proteins with 156071465
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
(946 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 1876 0.0
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 803 0.0
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 784 0.0
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 763 0.0
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 737 0.0
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 737 0.0
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 112 2e-24
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 105 2e-22
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 105 2e-22
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 105 2e-22
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 105 3e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 105 3e-22
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 105 3e-22
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 105 3e-22
gi|54860079 nadrin isoform 1 [Homo sapiens] 105 3e-22
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 105 3e-22
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 105 3e-22
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 102 2e-21
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 102 2e-21
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 102 2e-21
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 102 2e-21
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 100 6e-21
gi|51479148 Rho GTPase activating protein 20 [Homo sapiens] 100 1e-20
gi|23510413 sorting nexin 26 [Homo sapiens] 99 1e-20
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 98 3e-20
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 97 9e-20
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 97 9e-20
gi|188497642 ARHGAP15 [Homo sapiens] 96 1e-19
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 96 2e-19
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 96 2e-19
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 1876 bits (4860), Expect = 0.0
Identities = 946/946 (100%), Positives = 946/946 (100%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE
Sbjct: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL
Sbjct: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
Query: 181 AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT 240
AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT
Sbjct: 181 AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT 240
Query: 241 KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ 300
KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ
Sbjct: 241 KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ 300
Query: 301 GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP 360
GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP
Sbjct: 301 GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP 360
Query: 361 RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD 420
RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD
Sbjct: 361 RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD 420
Query: 421 PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSW 480
PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSW
Sbjct: 421 PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSW 480
Query: 481 TQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEG 540
TQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEG
Sbjct: 481 TQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEG 540
Query: 541 IFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE 600
IFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE
Sbjct: 541 IFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE 600
Query: 601 LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF 660
LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF
Sbjct: 601 LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF 660
Query: 661 GPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGD 720
GPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGD
Sbjct: 661 GPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGD 720
Query: 721 AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERAS 780
AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERAS
Sbjct: 721 AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERAS 780
Query: 781 SDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPC 840
SDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPC
Sbjct: 781 SDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPC 840
Query: 841 TSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSP 900
TSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSP
Sbjct: 841 TSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSP 900
Query: 901 SPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH 946
SPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH
Sbjct: 901 SPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH 946
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 803 bits (2074), Expect = 0.0
Identities = 411/806 (50%), Positives = 569/806 (70%), Gaps = 10/806 (1%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
M++ K ++++ + AEYE Q+KE+R QL EQ +CLE Q E R +LLQ+L EF RR+AE+E
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
LEYSR LEKLAERFSS+ + SSREHQ F+K+ LLSP++CW ++L TR++SR+ A L
Sbjct: 61 LEYSRSLEKLAERFSSK---IRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATL 116
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
+++ + RLS I+EDV RL KKS+++ Q+ +ELL+V +EL T KTY YH ES++
Sbjct: 117 NDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESIS 176
Query: 181 AEAKLREAERQEEKRAGRSVPTT-TAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKC 239
AE+KL+EAE+QEEK+ +S + E P R+SS+KK ++ EKRQAK+ E+KLKC
Sbjct: 177 AESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKC 236
Query: 240 TKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQV 299
TKARN+YLL+LA+ NAA+S YY+HDV DL+DCCD GFH +L + R+Y +AE + S+
Sbjct: 237 TKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRH 296
Query: 300 QGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEIL 359
+GL +E AV+ LD DK V+++ VFCPPL+F++ PH GDEV ++ + ++ E+L
Sbjct: 297 EGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELL 356
Query: 360 PRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSS 419
R +QSRL IE EEV KTL AT+Q L +++ +D DV D+FQ S STES+KS +S
Sbjct: 357 MRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAAS 416
Query: 420 DP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQE 477
+ +RR QQETE FY TK +EY++G +++ KLQAKH+ L++ L G++ E
Sbjct: 417 ETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECG 476
Query: 478 VSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQ 537
+ K QK R+PRP S Y+ +LF G ME FI+ SGQ +PLVVESCIR+INL GLQ
Sbjct: 477 TTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQ 536
Query: 538 HEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDL 597
+GIFRV G+Q+ V++I+++FERGEDPLV+ D++SVAGVLKLYFR LE PLFP +
Sbjct: 537 QQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKER 596
Query: 598 FGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLA 657
F +L+++ +LE AERV + ++L LP V+VV+RYLF FLNHL+QYSDENMMDPYNLA
Sbjct: 597 FQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLA 656
Query: 658 VCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASC 717
+CFGPTL+ +P GQDPV+ Q +N++++T+I+ + +FP L GPVYEKCMA C
Sbjct: 657 ICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYC 716
Query: 718 LGDAQLESLGADNEPELE-AEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
D+ GA +E + + P D+ +EA+A F Y GR+ +ELSF++G L L+
Sbjct: 717 --DSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLY 774
Query: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
RAS DWW G HNG+ GLIPH+YI +
Sbjct: 775 HRASEDWWEGRHNGVDGLIPHQYIVV 800
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
Length = 1085
Score = 784 bits (2025), Expect = 0.0
Identities = 394/806 (48%), Positives = 559/806 (69%), Gaps = 11/806 (1%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
M+ + ++++ + AEYE+QVKE+R QL EQ +CLE Q E+R +LLQ+L +F R++AE+E
Sbjct: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
EYSR LEKLAERF ++ S+++HQ ++K+ +LLSP++CW +LL R++S++ A L
Sbjct: 61 TEYSRNLEKLAERFMAK---TRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATL 117
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
S++ + R I+ED R+ KKS+++ QL ++L++V++EL T KTY YH ES++
Sbjct: 118 SDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESIS 177
Query: 181 AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT 240
AE+KL+EAE+QEEK+ GRS E R+SS+KK ++ EKRQAK+ E+KLK
Sbjct: 178 AESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSI 237
Query: 241 KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ 300
KARNEYLL+L + NA+V YY+HD+ DL+DCCD G+H +L + LR+Y +AE + S+ +
Sbjct: 238 KARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHE 297
Query: 301 GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP 360
GL +E AV+ L+P DK + +E++ FCPP++F++ H GDEV ++ + ++ E++
Sbjct: 298 GLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELML 357
Query: 361 RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD 420
R Q +QSRL IE EEV KT +ATLQ + ++V +D DV + FQ S STES+KST S+
Sbjct: 358 RYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSE 417
Query: 421 P--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEV 478
+RR QQETE FY KL+EYL G +++ KLQAKH+ LQ L G + E
Sbjct: 418 TYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMT 477
Query: 479 SWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQH 538
+ K QK R+ RP SQYN +LF GD+E F++ SGQ +PL+VESCIRFINL GLQH
Sbjct: 478 TRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQH 537
Query: 539 EGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLF 598
+GIFRVSG+Q+ V++I+++FERGE+PL + + HD++SVAGVLKLYFR LE PLFP + F
Sbjct: 538 QGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERF 597
Query: 599 GELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAV 658
+L++ ++ ER H+ +LL LP VL+V+RYLF FLNHL+QYSDENMMDPYNLA+
Sbjct: 598 NDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAI 657
Query: 659 CFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCL 718
CFGPTL+PVP QD V+ Q VN++++T+I+ + +FP L GPVYEKCMA
Sbjct: 658 CFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYC-- 715
Query: 719 GDAQLESLGADNEPELEA--EMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
D+ G E + +A E ED+ E +EA+A F Y GR+A+ELSF++G L L+
Sbjct: 716 -DSPYSEHGTLEEVDQDAGTEPHTSEDECE-PIEAIAKFDYVGRSARELSFKKGASLLLY 773
Query: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
RAS DWW G HNG+ GL+PH+YI +
Sbjct: 774 HRASEDWWEGRHNGIDGLVPHQYIVV 799
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 763 bits (1971), Expect = 0.0
Identities = 398/806 (49%), Positives = 555/806 (68%), Gaps = 34/806 (4%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
M++ K ++++ + AEYE Q+KE+R QL EQ +CLE Q E R +LLQ+L EF RR+AE+E
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
LEYSR LEKLAERFSS+ + SSREHQ F+K+ LLSP++CW ++L TR++SR+ A L
Sbjct: 61 LEYSRSLEKLAERFSSK---IRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATL 116
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
+++ + RLS I+EDV RL KKS+++ Q+ +ELL+V +EL T KTY YH ES++
Sbjct: 117 NDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESIS 176
Query: 181 AEAKLREAERQEEKRAGRSVPTT-TAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKC 239
AE+KL+EAE+QEEK+ +S + E P R+SS+KK ++ EKRQAK+ E+KLKC
Sbjct: 177 AESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKC 236
Query: 240 TKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQV 299
TKARN+YLL+LA+ NAA+S YY+HDV DL+DCCD GFH +L + R+Y +AE + S+
Sbjct: 237 TKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRH 296
Query: 300 QGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEIL 359
+GL +E AV+ LD DK V+++ VFCPPL+F++ PH GDEV ++ + ++ E+L
Sbjct: 297 EGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELL 356
Query: 360 PRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSS 419
R +QSRL IE EEV KTL AT+Q L +++ +D DV D+FQ S STES+KS +S
Sbjct: 357 MRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAAS 416
Query: 420 DP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQE 477
+ +RR QQETE FY TK +EY++G +++ KLQAKH+ L++ L G++ E
Sbjct: 417 ETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECG 476
Query: 478 VSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQ 537
+ R+ ++R Q SGQ +PLVVESCIR+INL GLQ
Sbjct: 477 TT----RGRRNARTRN--------------------QDSGQAIPLVVESCIRYINLYGLQ 512
Query: 538 HEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDL 597
+GIFRV G+Q+ V++I+++FERGEDPLV+ D++SVAGVLKLYFR LE PLFP +
Sbjct: 513 QQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKER 572
Query: 598 FGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLA 657
F +L+++ +LE AERV + ++L LP V+VV+RYLF FLNHL+QYSDENMMDPYNLA
Sbjct: 573 FQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLA 632
Query: 658 VCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASC 717
+CFGPTL+ +P GQDPV+ Q +N++++T+I+ + +FP L GPVYEKCMA C
Sbjct: 633 ICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYC 692
Query: 718 LGDAQLESLGADNEPELE-AEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
D+ GA +E + + P D+ +EA+A F Y GR+ +ELSF++G L L+
Sbjct: 693 --DSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLY 750
Query: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
RAS DWW G HNG+ GLIPH+YI +
Sbjct: 751 HRASEDWWEGRHNGVDGLIPHQYIVV 776
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 737 bits (1903), Expect = 0.0
Identities = 380/825 (46%), Positives = 556/825 (67%), Gaps = 47/825 (5%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
M + K ++++ + AEY+TQVKE+R QL+EQ++CL+ Q ELR +LLQ+L +F R++AE+E
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
++YSR LEKLAERF ++ S + Q F+K+ ++LSP++CW +LL +++SR+ L
Sbjct: 61 MDYSRNLEKLAERFLAKT----RSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTL 116
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
S++ + R ++ED GRL KKS+++ QQLQD+L++V++EL + KTY Y+ +S++
Sbjct: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
Query: 181 AEAKLREAERQEEKRAGRSV----------PTTTAGAT-EAGPLRKSSLKKGGRLVEKRQ 229
A++KL+EAE+QEEK+ G+SV P +TA E +R+SS+KK ++ EKRQ
Sbjct: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQ 236
Query: 230 AKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMD-CCDTGFHLALGQVLRSYT 288
AK+ E+KLK KARNEYLL+L + NA+V YY+HD+ DL+D CCD G+H +L + LR++
Sbjct: 237 AKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFL 296
Query: 289 AAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEI 348
+AE + S+ +GL ++E AVE LD DK +++E++ VFCPP++F++ PH GD +++
Sbjct: 297 SAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
Query: 349 CVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTS 408
C + ++ E++ R Q +QSRL IE EEV KT++ATLQ + ++V +D DV D FQ S
Sbjct: 357 CAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYS 416
Query: 409 PSTESLKSTSSDP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQE 466
S ES+KST S+ +RR QQETE FY TK++EYL GR+++ KLQAKH+ LQ+
Sbjct: 417 NSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQK 476
Query: 467 ALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES 526
L + + ++ T RK Q S Q +PLVVES
Sbjct: 477 TLGESQRTDCSLARRSSTVRK--------------------------QDSSQAIPLVVES 510
Query: 527 CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFR 586
CIRFI+ +GLQHEGIFRVSG+Q+ V++I++AFERGEDPL HD+DS+AGVLKLYFR
Sbjct: 511 CIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFR 570
Query: 587 SLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYS 646
LE PLFP D+F +L+A ++ ER H+ ++L LP L+++RYLF FLNHL+Q+S
Sbjct: 571 GLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFS 630
Query: 647 DENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVY 706
+ENMMDPYNLA+CFGP+L+ VP G D V+ Q VN+L++T+I+Q + +FP L GPVY
Sbjct: 631 EENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVY 690
Query: 707 EKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELS 766
+ + + S+ D+ ++ AE +D+ E +EA+A F Y GRTA+ELS
Sbjct: 691 SRGGSMEDYCDSPHGETTSV-EDSTQDVTAEHHTSDDECE-PIEAIAKFDYVGRTARELS 748
Query: 767 FRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVV 811
F++G L L++RAS DWW G HNG+ GLIPH+YI + TE VV
Sbjct: 749 FKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVV-QDTEDGVV 792
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 737 bits (1903), Expect = 0.0
Identities = 380/825 (46%), Positives = 556/825 (67%), Gaps = 47/825 (5%)
Query: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
M + K ++++ + AEY+TQVKE+R QL+EQ++CL+ Q ELR +LLQ+L +F R++AE+E
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
++YSR LEKLAERF ++ S + Q F+K+ ++LSP++CW +LL +++SR+ L
Sbjct: 61 MDYSRNLEKLAERFLAKT----RSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTL 116
Query: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
S++ + R ++ED GRL KKS+++ QQLQD+L++V++EL + KTY Y+ +S++
Sbjct: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
Query: 181 AEAKLREAERQEEKRAGRSV----------PTTTAGAT-EAGPLRKSSLKKGGRLVEKRQ 229
A++KL+EAE+QEEK+ G+SV P +TA E +R+SS+KK ++ EKRQ
Sbjct: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQ 236
Query: 230 AKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMD-CCDTGFHLALGQVLRSYT 288
AK+ E+KLK KARNEYLL+L + NA+V YY+HD+ DL+D CCD G+H +L + LR++
Sbjct: 237 AKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFL 296
Query: 289 AAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEI 348
+AE + S+ +GL ++E AVE LD DK +++E++ VFCPP++F++ PH GD +++
Sbjct: 297 SAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
Query: 349 CVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTS 408
C + ++ E++ R Q +QSRL IE EEV KT++ATLQ + ++V +D DV D FQ S
Sbjct: 357 CAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYS 416
Query: 409 PSTESLKSTSSDP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQE 466
S ES+KST S+ +RR QQETE FY TK++EYL GR+++ KLQAKH+ LQ+
Sbjct: 417 NSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQK 476
Query: 467 ALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES 526
L + + ++ T RK Q S Q +PLVVES
Sbjct: 477 TLGESQRTDCSLARRSSTVRK--------------------------QDSSQAIPLVVES 510
Query: 527 CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFR 586
CIRFI+ +GLQHEGIFRVSG+Q+ V++I++AFERGEDPL HD+DS+AGVLKLYFR
Sbjct: 511 CIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFR 570
Query: 587 SLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYS 646
LE PLFP D+F +L+A ++ ER H+ ++L LP L+++RYLF FLNHL+Q+S
Sbjct: 571 GLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFS 630
Query: 647 DENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVY 706
+ENMMDPYNLA+CFGP+L+ VP G D V+ Q VN+L++T+I+Q + +FP L GPVY
Sbjct: 631 EENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVY 690
Query: 707 EKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELS 766
+ + + S+ D+ ++ AE +D+ E +EA+A F Y GRTA+ELS
Sbjct: 691 SRGGSMEDYCDSPHGETTSV-EDSTQDVTAEHHTSDDECE-PIEAIAKFDYVGRTARELS 748
Query: 767 FRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVV 811
F++G L L++RAS DWW G HNG+ GLIPH+YI + TE VV
Sbjct: 749 FKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVV-QDTEDGVV 792
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 112 bits (279), Expect = 2e-24
Identities = 102/447 (22%), Positives = 182/447 (40%), Gaps = 28/447 (6%)
Query: 304 SLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMEL---RDEILP 360
++ E+ + LDP K LE+ + +++A I E E+ RD + P
Sbjct: 80 TMAESFKELDPDSSMGKALEMSCAI-------------QNQLARILAEFEMTLERDVLQP 126
Query: 361 RAQNIQSRLDRQTIETEEVNK------TLKATLQALLEVVASDDGDVLDSFQTSPSTESL 414
++ + L + + K TLK+ L + S G S +T +
Sbjct: 127 LSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMAN 186
Query: 415 KSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKE 474
K + + R+ Q ++ YL L +++ A + ++Q R
Sbjct: 187 KVETLKEEEEELKRKVEQCRDE---YLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLS 243
Query: 475 EQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLN 534
+ + + + Q P ++ + R++G + +Q G+ + L +E+C+ +
Sbjct: 244 SLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSE 303
Query: 535 GLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFP 594
G++ EG+FR++ + ++ L E C+ D +VAG LK Y R L PL
Sbjct: 304 GMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCS--DPHAVAGALKSYLRELPEPLMT 361
Query: 595 PDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPY 654
DL+ + + ++ L+ R++ + + RLP L LRYL FL LA+ + N M P
Sbjct: 362 FDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPS 421
Query: 655 NLAVCFGPTLLPVPAGQ-DPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPP 713
N+A+ GP LL P + D L +Q + V + T PG +
Sbjct: 422 NIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLF 481
Query: 714 SASCLGDAQLESLGADNEPELEAEMPA 740
SA L D + L ++ P PA
Sbjct: 482 SAVTLQDTVSDRLASEELPSTAVPTPA 508
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 105 bits (263), Expect = 2e-22
Identities = 67/206 (32%), Positives = 112/206 (54%), Gaps = 12/206 (5%)
Query: 500 YNQRLFGGDMEKFIQSS----GQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIR 555
+ + +FG +E ++ + P++VE C+ FI GL+ EG+FR+ G V E++
Sbjct: 35 FRKGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQ 94
Query: 556 DAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAER-- 613
DAF+ GE P + T D+ +VA +LKLY R L P+ P + + L+ ++L + E
Sbjct: 95 DAFDCGEKPSFDSNT--DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG 152
Query: 614 VEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDP 673
V+ +++ + LP +L+Y+ FL+ + YS N M NLA FGP +L P +DP
Sbjct: 153 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDP 211
Query: 674 VALQGR---VNQLVQTLIVQPDRVFP 696
+ + V QL+ +I + D +FP
Sbjct: 212 LTIMEGTVVVQQLMSVMISKHDCLFP 237
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 105 bits (262), Expect = 2e-22
Identities = 69/229 (30%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 475 EQEVSWTQYTQRKFQKSRQP----RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRF 530
E ++S ++ RKF + R R ++FG + + VP V+ CIR
Sbjct: 293 ESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRA 352
Query: 531 INLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEP 590
+ GL +G++R+SG + ++R + E ++ D+ + G LKL+FR L
Sbjct: 353 VEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPE 412
Query: 591 PLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENM 650
PLFP F + +A+ +L+ A R V L+ LPAP LR LF L + ++ ++N
Sbjct: 413 PLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNR 472
Query: 651 MDPYNLAVCFGPTLL--PVPAGQDPVALQGRVNQLVQTLIVQPDRVFPP 697
M ++A+ FGPTLL V P+ + + NQ+V+ ++ Q +FPP
Sbjct: 473 MSVQSVAIVFGPTLLRPEVEETSMPMTMVFQ-NQVVELILQQCADIFPP 520
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 105 bits (262), Expect = 2e-22
Identities = 69/229 (30%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 475 EQEVSWTQYTQRKFQKSRQP----RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRF 530
E ++S ++ RKF + R R ++FG + + VP V+ CIR
Sbjct: 320 ESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRA 379
Query: 531 INLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEP 590
+ GL +G++R+SG + ++R + E ++ D+ + G LKL+FR L
Sbjct: 380 VEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPE 439
Query: 591 PLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENM 650
PLFP F + +A+ +L+ A R V L+ LPAP LR LF L + ++ ++N
Sbjct: 440 PLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNR 499
Query: 651 MDPYNLAVCFGPTLL--PVPAGQDPVALQGRVNQLVQTLIVQPDRVFPP 697
M ++A+ FGPTLL V P+ + + NQ+V+ ++ Q +FPP
Sbjct: 500 MSVQSVAIVFGPTLLRPEVEETSMPMTMVFQ-NQVVELILQQCADIFPP 547
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 105 bits (261), Expect = 3e-22
Identities = 64/181 (35%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
Query: 521 PLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGV 580
P++VE C+ FI GL+ EG+FR+ G V E++DAF+ GE P + T D+ +VA +
Sbjct: 58 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT--DVHTVASL 115
Query: 581 LKLYFRSLEPPLFPPDLFGELLASSELEATAER--VEHVSRLLWRLPAPVLVVLRYLFTF 638
LKLY R L P+ P + + L+ ++L + E V+ +++ + LP +L+Y+ F
Sbjct: 116 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 175
Query: 639 LNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGR---VNQLVQTLIVQPDRVF 695
L+ + YS N M NLA FGP +L P +DP+ + V QL+ +I + D +F
Sbjct: 176 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 234
Query: 696 P 696
P
Sbjct: 235 P 235
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 105 bits (261), Expect = 3e-22
Identities = 64/181 (35%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
Query: 521 PLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGV 580
P++VE C+ FI GL+ EG+FR+ G V E++DAF+ GE P + T D+ +VA +
Sbjct: 153 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT--DVHTVASL 210
Query: 581 LKLYFRSLEPPLFPPDLFGELLASSELEATAER--VEHVSRLLWRLPAPVLVVLRYLFTF 638
LKLY R L P+ P + + L+ ++L + E V+ +++ + LP +L+Y+ F
Sbjct: 211 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 270
Query: 639 LNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGR---VNQLVQTLIVQPDRVF 695
L+ + YS N M NLA FGP +L P +DP+ + V QL+ +I + D +F
Sbjct: 271 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 329
Query: 696 P 696
P
Sbjct: 330 P 330
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 105 bits (261), Expect = 3e-22
Identities = 63/204 (30%), Positives = 104/204 (50%), Gaps = 3/204 (1%)
Query: 495 RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEI 554
+P + ++++ D+ +++ P+VV+ CIR I GL+ EG++RVSG + ++
Sbjct: 265 QPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDV 324
Query: 555 RDAFER-GEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAER 613
+ AF+R GE + D++ + G LKLYFR L P+ D + + + ++++ ER
Sbjct: 325 KMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADER 384
Query: 614 VEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDP 673
+E V +L LP LRYL L + +N M+ NL + FGPTL+ P
Sbjct: 385 LEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTL 444
Query: 674 VALQGRVNQ--LVQTLIVQPDRVF 695
L Q +VQ LI D +F
Sbjct: 445 TTLHDMRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 105 bits (261), Expect = 3e-22
Identities = 63/204 (30%), Positives = 104/204 (50%), Gaps = 3/204 (1%)
Query: 495 RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEI 554
+P + ++++ D+ +++ P+VV+ CIR I GL+ EG++RVSG + ++
Sbjct: 129 QPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDV 188
Query: 555 RDAFER-GEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAER 613
+ AF+R GE + D++ + G LKLYFR L P+ D + + + ++++ ER
Sbjct: 189 KMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADER 248
Query: 614 VEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDP 673
+E V +L LP LRYL L + +N M+ NL + FGPTL+ P
Sbjct: 249 LEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTL 308
Query: 674 VALQGRVNQ--LVQTLIVQPDRVF 695
L Q +VQ LI D +F
Sbjct: 309 TTLHDMRYQKLIVQILIENEDVLF 332
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 105 bits (261), Expect = 3e-22
Identities = 140/620 (22%), Positives = 239/620 (38%), Gaps = 82/620 (13%)
Query: 347 EICVEMELRDEI-------LPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDG 399
E+ VE E+ D + +P Q + +L R ++ + V +A G
Sbjct: 112 EVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSV--------RARWNQAHKSSG 163
Query: 400 DVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQA 459
+FQ PS D + + + Q ++ K EY G+ + L+A
Sbjct: 164 T---NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEY--GKFFVTLLEA 218
Query: 460 KHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQP 519
+ + ++AL +K E+ R Q +P+ FG +E+ ++ SG+
Sbjct: 219 QADYHRKALAVLEKTLPEM-------RAHQDKWAEKPA-------FGTPLEEHLKRSGRE 264
Query: 520 VPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAG 579
+ L +E+C+ + G++ EG+FR+ ++ +++ A + L E + D +VAG
Sbjct: 265 IALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYS--DPHAVAG 322
Query: 580 VLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFL 639
LK Y R L PL +L+ E + ++ ++++ + R +LP V RYL FL
Sbjct: 323 ALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFL 382
Query: 640 NHLAQYSDENMMDPYNLAVCFGPTLL----PVPAGQDPVALQGRVNQLVQTLIVQPDRVF 695
LAQ SD N M P N+A+ GP LL + A V +++ +I D F
Sbjct: 383 AKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFF 442
Query: 696 PPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPE---LEAEMPAQEDDLEGVVEAV 752
P + PS++ S N+ + LE + PA +EG + V
Sbjct: 443 PEEVEFNVSEAFVPLTTPSSN-------HSFHTGNDSDSGTLERKRPASMAVMEG--DLV 493
Query: 753 ACFAYTGRTAQELSFRRGDVL-RLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVV 811
++ + + RRG L R H + +G +PAG E
Sbjct: 494 KKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGS--------TVVPAGPEPPPQ 545
Query: 812 GAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAV 871
+ +++ G+ P E P + P+ P VPA + ++
Sbjct: 546 SSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVS----AAVPAPGRNNSQIASGQ 601
Query: 872 AQNMDSVFKELLGKTSVRQGLGPASTT------SPSPGPRSPKAPPSSRLGRNKGFSRGP 925
Q + L GP+ T P+P P P PP G
Sbjct: 602 NQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPG--------- 652
Query: 926 GAPASPSASHPQGLDTTPKP 945
G +S ++ HP L +PKP
Sbjct: 653 GQSSSGTSQHPPSL--SPKP 670
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 105 bits (261), Expect = 3e-22
Identities = 62/202 (30%), Positives = 107/202 (52%), Gaps = 2/202 (0%)
Query: 495 RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEI 554
+P ++ ++++ D+ +++ P+VV+ CIR I GL EG++RVSG + ++
Sbjct: 256 KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDV 315
Query: 555 RDAFER-GEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAER 613
+ AF+R GE + D++ + G LKLYFR L PL D + + + S+++ E+
Sbjct: 316 KMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQ 375
Query: 614 VEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDP 673
+E + L LP LRYL L + + EN+M+ NL + FGPTL+ P
Sbjct: 376 LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM 435
Query: 674 VALQG-RVNQLVQTLIVQPDRV 694
AL R +LV L+++ + +
Sbjct: 436 AALNDIRYQRLVVELLIKNEDI 457
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 105 bits (261), Expect = 3e-22
Identities = 62/202 (30%), Positives = 107/202 (52%), Gaps = 2/202 (0%)
Query: 495 RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEI 554
+P ++ ++++ D+ +++ P+VV+ CIR I GL EG++RVSG + ++
Sbjct: 230 KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDV 289
Query: 555 RDAFER-GEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAER 613
+ AF+R GE + D++ + G LKLYFR L PL D + + + S+++ E+
Sbjct: 290 KMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQ 349
Query: 614 VEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDP 673
+E + L LP LRYL L + + EN+M+ NL + FGPTL+ P
Sbjct: 350 LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM 409
Query: 674 VALQG-RVNQLVQTLIVQPDRV 694
AL R +LV L+++ + +
Sbjct: 410 AALNDIRYQRLVVELLIKNEDI 431
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 102 bits (254), Expect = 2e-21
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 4/197 (2%)
Query: 503 RLFGGDMEKFIQSS-GQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERG 561
R FG +E+ ++ Q VPL+V +C R + GL+ GI+RV G VS +++ RG
Sbjct: 807 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG 866
Query: 562 EDPL-VEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRL 620
+ ++ DL+ ++ +LK +FR L PLF D + + + ++ +E ER+ + +L
Sbjct: 867 PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL 926
Query: 621 LWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQ--DPVALQG 678
+ LP L++L L +A +S++N M+P NLA+ FGPTL+ D V
Sbjct: 927 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP 986
Query: 679 RVNQLVQTLIVQPDRVF 695
++V+TLI D F
Sbjct: 987 DRYKIVETLIQHSDWFF 1003
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 102 bits (254), Expect = 2e-21
Identities = 71/190 (37%), Positives = 98/190 (51%), Gaps = 14/190 (7%)
Query: 521 PLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGV 580
PL+VE C+ FI GL EG+FR+ G V +++D+F+ GE PL + T D+ +VA +
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTT--DVHTVASL 230
Query: 581 LKLYFRSLEPPLFPPDLF------GELLASSELEATAERVEHVSRLLWRLPAPVLVVLRY 634
LKLY R L P+ P + +LL E E T E + VS LP +LRY
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVS----NLPQANYNLLRY 286
Query: 635 LFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRV 694
+ FL+ + YS+ N M NLA FGP +L P +DPV + LVQ L+ R
Sbjct: 287 ICKFLDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIM-EGTSLVQHLMTVLIRK 344
Query: 695 FPPLTSLPGP 704
L + P P
Sbjct: 345 HSQLFTAPVP 354
Score = 31.6 bits (70), Expect = 3.7
Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 1/84 (1%)
Query: 110 TRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKK 169
TR+ +R S AL + L L L + R VK+ + L+ + + EL KK
Sbjct: 589 TREHARRSEAL-QGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQEKK 647
Query: 170 TYQAYHMESVNAEAKLREAERQEE 193
Y ++ N+E +AER+ +
Sbjct: 648 KYIMLEIKLRNSERAREDAERRNQ 671
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 102 bits (253), Expect = 2e-21
Identities = 91/316 (28%), Positives = 127/316 (40%), Gaps = 62/316 (19%)
Query: 414 LKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSG------------RSILAKLQAKH 461
L+ + S P AG ++ E + L +L S R+ L +L AK
Sbjct: 445 LRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKR 504
Query: 462 EKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVP 521
LQ +RG +Q +FG +E Q G VP
Sbjct: 505 PPLQSLQERGLLRDQ---------------------------VFGCQLESLCQREGDTVP 537
Query: 522 LVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERG------------EDPLVEGC 569
+ CI ++ GL +GI+RVSG V ++R +R E P EG
Sbjct: 538 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGR 597
Query: 570 TAHDLDS--------VAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLL 621
DLDS V G LKL+ R L PL PP L A+ L + + + + L+
Sbjct: 598 L--DLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELI 655
Query: 622 WRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLL-PVPAGQDPVALQGRV 680
+P P LRYL L + +SD+N M P+NL + FGPTL P DP A
Sbjct: 656 GSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYP 715
Query: 681 NQLVQTLIVQPDRVFP 696
QLVQ ++ +FP
Sbjct: 716 GQLVQLMLTNFTSLFP 731
Score = 35.0 bits (79), Expect = 0.33
Identities = 14/34 (41%), Positives = 19/34 (55%)
Query: 751 AVACFAYTGRTAQELSFRRGDVLRLHERASSDWW 784
A+ F YTG Q++S GD L + +SDWW
Sbjct: 29 ALYAFTYTGADGQQVSLAEGDRFLLLRKTNSDWW 62
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 102 bits (253), Expect = 2e-21
Identities = 91/316 (28%), Positives = 127/316 (40%), Gaps = 62/316 (19%)
Query: 414 LKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSG------------RSILAKLQAKH 461
L+ + S P AG ++ E + L +L S R+ L +L AK
Sbjct: 261 LRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKR 320
Query: 462 EKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVP 521
LQ +RG +Q +FG +E Q G VP
Sbjct: 321 PPLQSLQERGLLRDQ---------------------------VFGCQLESLCQREGDTVP 353
Query: 522 LVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERG------------EDPLVEGC 569
+ CI ++ GL +GI+RVSG V ++R +R E P EG
Sbjct: 354 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGR 413
Query: 570 TAHDLDS--------VAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLL 621
DLDS V G LKL+ R L PL PP L A+ L + + + + L+
Sbjct: 414 L--DLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELI 471
Query: 622 WRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLL-PVPAGQDPVALQGRV 680
+P P LRYL L + +SD+N M P+NL + FGPTL P DP A
Sbjct: 472 GSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYP 531
Query: 681 NQLVQTLIVQPDRVFP 696
QLVQ ++ +FP
Sbjct: 532 GQLVQLMLTNFTSLFP 547
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 100 bits (249), Expect = 6e-21
Identities = 77/321 (23%), Positives = 145/321 (45%), Gaps = 28/321 (8%)
Query: 423 SRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQ 482
+++ GR RG +++ + + + +I + + +K+++ + ++++
Sbjct: 1186 TKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKK------ 1239
Query: 483 YTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIF 542
Q+K K+ P + FG ++ + + +P+PL VE C+ FI GL EG++
Sbjct: 1240 --QKKKTKNFNPPTRRNWESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTEGLY 1296
Query: 543 RVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELL 602
RVSG + I+ F++ + + +++VAG LK +F L PL P L ELL
Sbjct: 1297 RVSGNKTDQDNIQKQFDQDHNINLVSMEV-TVNAVAGALKAFFADLPDPLIPYSLHPELL 1355
Query: 603 ASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGP 662
++++ ER+ + ++ + V RY+ T LN ++Q N+M NL++CF P
Sbjct: 1356 EAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWP 1415
Query: 663 TLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVF--------------PPLTSLPGPVYEK 708
TL+ +++Q V +Q + F PP S PG + E
Sbjct: 1416 TLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEP 1475
Query: 709 C----MAPPSASCLGDAQLES 725
+ PP L QL++
Sbjct: 1476 MVPLQLPPPLQPQLIQPQLQT 1496
>gi|51479148 Rho GTPase activating protein 20 [Homo sapiens]
Length = 1191
Score = 99.8 bits (247), Expect = 1e-20
Identities = 89/333 (26%), Positives = 152/333 (45%), Gaps = 16/333 (4%)
Query: 421 PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSIL--AKLQAKHEKLQEALQRGDKEEQEV 478
PGS+ + Q E F + +L + + IL ++L A + + + +
Sbjct: 279 PGSKDSTTPFNLQ---EPFLMEQLPREMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSII 335
Query: 479 SWTQYTQRKFQKSRQPR-PSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQ 537
+W + P P+S +LFG + ++ P P++ + F+N G
Sbjct: 336 NWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNICENDNLPKPVL--DMLFFLNQKGPL 393
Query: 538 HEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDL 597
+GIFR S E+++ G + ++ + +A VLK + R++ +F DL
Sbjct: 394 TKGIFRQSANVKSCRELKEKLNSGVEVHLD---CESIFVIASVLKDFLRNIPGSIFSSDL 450
Query: 598 FGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLA 657
+ ++ + E++ V RLL +LP +V+LRYLF L+++ Q+S N M +NLA
Sbjct: 451 YDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLA 510
Query: 658 VCFGPTLLPVPAGQDPV---ALQGRVNQLVQTLIVQPDRVF-PPLTSLPGPVYEKCMAPP 713
VC P++L PA P +V+ L+Q LI R+F +TSL V +C
Sbjct: 511 VCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFREVSVRCDTRE 570
Query: 714 SASCLGDAQLESLGADN-EPELEAEMPAQEDDL 745
+AS + QL D+ E EL ++ A DL
Sbjct: 571 NASDISCFQLNDSSYDSLENELNEDVDAPCSDL 603
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 99.4 bits (246), Expect = 1e-20
Identities = 61/185 (32%), Positives = 94/185 (50%), Gaps = 6/185 (3%)
Query: 486 RKFQKSRQPRPSSQYN----QRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGI 541
R F +SR R + QR+FG D+ + + +SGQ VP V+ C FI +G+ +GI
Sbjct: 290 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV-DGI 348
Query: 542 FRVSGAQLRVSEIRDAFERGEDPLVEG-CTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE 600
+R+SG + +R F+ P + G D+ SV+ + KLYFR L PL L+G+
Sbjct: 349 YRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGK 408
Query: 601 LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF 660
+ + ER+ V ++ +LP P L YL L +A++S M NLA+ +
Sbjct: 409 FSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVW 468
Query: 661 GPTLL 665
P LL
Sbjct: 469 APNLL 473
Score = 33.5 bits (75), Expect = 0.96
Identities = 17/62 (27%), Positives = 29/62 (46%), Gaps = 3/62 (4%)
Query: 744 DLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSD---WWRGEHNGMRGLIPHKYI 800
++ V A YT + ELSF GD++ + + ++ WWRG+ G P + +
Sbjct: 184 NIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECV 243
Query: 801 TL 802
L
Sbjct: 244 EL 245
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 98.2 bits (243), Expect = 3e-20
Identities = 76/321 (23%), Positives = 144/321 (44%), Gaps = 29/321 (9%)
Query: 423 SRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQ 482
+++ GR RG +++ + + + +I + + +K+++ + ++++
Sbjct: 1186 TKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKK------ 1239
Query: 483 YTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIF 542
+K K+ P + FG ++ + + +P+PL VE C+ FI GL EG++
Sbjct: 1240 ---KKKTKNFNPPTRRNWESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTEGLY 1295
Query: 543 RVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELL 602
RVSG + I+ F++ + + +++VAG LK +F L PL P L ELL
Sbjct: 1296 RVSGNKTDQDNIQKQFDQDHNINLVSMEV-TVNAVAGALKAFFADLPDPLIPYSLHPELL 1354
Query: 603 ASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGP 662
++++ ER+ + ++ + V RY+ T LN ++Q N+M NL++CF P
Sbjct: 1355 EAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWP 1414
Query: 663 TLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVF--------------PPLTSLPGPVYEK 708
TL+ +++Q V +Q + F PP S PG + E
Sbjct: 1415 TLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEP 1474
Query: 709 C----MAPPSASCLGDAQLES 725
+ PP L QL++
Sbjct: 1475 MVPLQLPPPLQPQLIQPQLQT 1495
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 96.7 bits (239), Expect = 9e-20
Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 3/178 (1%)
Query: 490 KSRQP-RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQ 548
KSRQ + +R+FG D+++ +Q SGQ VP V++SC F+ G+ +GI+R+SG
Sbjct: 2 KSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVS 60
Query: 549 LRVSEIRDAFERGEDP-LVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSEL 607
+ ++R FE P L D+ V+ + K YFR L PL L+ + + +
Sbjct: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
Query: 608 EATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLL 665
+ ER+ + +L LP P L +L L H+A +S + M NLA+ + P LL
Sbjct: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLL 178
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 96.7 bits (239), Expect = 9e-20
Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 3/178 (1%)
Query: 490 KSRQP-RPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQ 548
KSRQ + +R+FG D+++ +Q SGQ VP V++SC F+ G+ +GI+R+SG
Sbjct: 2 KSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVS 60
Query: 549 LRVSEIRDAFERGEDP-LVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSEL 607
+ ++R FE P L D+ V+ + K YFR L PL L+ + + +
Sbjct: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
Query: 608 EATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLL 665
+ ER+ + +L LP P L +L L H+A +S + M NLA+ + P LL
Sbjct: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLL 178
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 96.3 bits (238), Expect = 1e-19
Identities = 54/194 (27%), Positives = 96/194 (49%), Gaps = 1/194 (0%)
Query: 503 RLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGE 562
++FG + K + VP V+ CI + GL +GI+RVSG + ++R + E
Sbjct: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEE 336
Query: 563 DPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLW 622
++ D+ V G LK++FR L PLFP F + + + + + R+E V L+
Sbjct: 337 KLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQ 396
Query: 623 RLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVAL-QGRVN 681
+LP P ++ LF L + + +N+M +L + FGPTLL +A+ N
Sbjct: 397 KLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQN 456
Query: 682 QLVQTLIVQPDRVF 695
Q+ + ++ + ++F
Sbjct: 457 QIAELMLSEYSKIF 470
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 95.9 bits (237), Expect = 2e-19
Identities = 159/718 (22%), Positives = 275/718 (38%), Gaps = 107/718 (14%)
Query: 46 LQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAV 105
+++L ++ +R +E+E+++GL+K+A QS +EP + L +++
Sbjct: 296 MKDLISYLEKRTTLEMEFAKGLQKIAHNC------------RQSVMQEPHM-PLLSIYSL 342
Query: 106 LLQ------HTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLE 159
L+ H+ Q+ + + +RL H + K+ ++ + Q +L E
Sbjct: 343 ALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEH-----EKRRKEIKEAWHRAQRKLQE 397
Query: 160 VVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLK 219
S L+ AK+ Y + A + +AE ++ A + T T + L + +
Sbjct: 398 AESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKN 457
Query: 220 KGGRLVEKRQ-----AKFMEHKLKCTKA------RNEYLLSLASVNAAVSNYY--LHDV- 265
K + + AK + +L+ TK + S ++ +A +YY +H
Sbjct: 458 KAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQT 517
Query: 266 ----LDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKV 321
+ C++ GQ S+ R Q V + A P +A+
Sbjct: 518 APLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVM-RARK 576
Query: 322 LEVHATVFCPPLRFDYHPHDGDEVAEICVE-MELRDEILPRAQNIQSRLDRQTIETEE-- 378
+ + P P +G C E +D R + +++
Sbjct: 577 SSFNVSDVARPEAAGSPPEEGG-----CTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGL 631
Query: 379 ------------VNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQA 426
+ T+ + E+V D G +F+ + T P + +
Sbjct: 632 DPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGM---TPELPVAVPS 688
Query: 427 G--RRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYT 484
G R G + T L KL+ R + + + + +E K+ E Q
Sbjct: 689 GPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCG 748
Query: 485 QRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRV 544
+K Q Q LFG D +S+ VP +V+ C+ I L+ +GI+RV
Sbjct: 749 HKKLQGRLQ----------LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRV 798
Query: 545 SGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGEL--L 602
+G + RV ++ AFE G++ LVE A D ++ VLKLY R L PL L+ EL L
Sbjct: 799 NGVKTRVEKLCQAFENGKE-LVELSQASPHD-ISNVLKLYLRQLPEPLISFRLYHELVGL 856
Query: 603 ASSELEATAER--------------------VEHVSRLLWRLPAPVLVVLRYLFTFLNHL 642
A L+A AE + LL LP L+YL L +
Sbjct: 857 AKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRI 916
Query: 643 AQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVN-----QLVQTLIVQPDRVF 695
+ +N M P NL + FGPTLL + V+L V+ ++++TLIV VF
Sbjct: 917 VEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 95.5 bits (236), Expect = 2e-19
Identities = 77/315 (24%), Positives = 147/315 (46%), Gaps = 21/315 (6%)
Query: 369 LDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKS-----TSSDPGS 423
+D ET+ N T A D D+L +T + +L T+ D S
Sbjct: 996 IDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLIS 1055
Query: 424 RQAGRRRGQQQETETFYLT-----KLQEYLSGRSILAKLQAKHEKLQEA----LQRGDKE 474
R+ + E T +++ L G K Q+ H +E+ L + D
Sbjct: 1056 RRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTS 1115
Query: 475 --EQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQS-SGQPVPLVVESCIRFI 531
+ + +W + +K+ + +P++ FG ++ + + + +PL+V+ C + +
Sbjct: 1116 PPKDKGTWRKGIPSIMRKTFEKKPTATGT---FGVRLDDCPPAHTNRYIPLIVDICCKLV 1172
Query: 532 NLNGLQHEGIFRVSGAQLRVSEIRDAFERG-EDPLVEGCTAHDLDSVAGVLKLYFRSLEP 590
GL++ GI+RV G +S +++ +G D ++ DL+ ++ +LK +FR L
Sbjct: 1173 EERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPE 1232
Query: 591 PLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENM 650
PLF D + + + ++ E +R++ + RL+ LP L++L L +A+ S++N
Sbjct: 1233 PLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNK 1292
Query: 651 MDPYNLAVCFGPTLL 665
M+P NLA+ FGPTL+
Sbjct: 1293 MEPRNLAIVFGPTLV 1307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,688,129
Number of Sequences: 37866
Number of extensions: 1989117
Number of successful extensions: 11688
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 474
Number of HSP's that attempted gapping in prelim test: 9768
Number of HSP's gapped (non-prelim): 2223
length of query: 946
length of database: 18,247,518
effective HSP length: 112
effective length of query: 834
effective length of database: 14,006,526
effective search space: 11681442684
effective search space used: 11681442684
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.