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Search of human proteins with 154354990
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
(1710 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 3336 0.0
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 723 0.0
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 600 e-171
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 600 e-171
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 600 e-171
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po... 567 e-161
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po... 561 e-159
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 539 e-152
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 539 e-152
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 539 e-152
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 499 e-140
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens] 486 e-137
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 469 e-131
gi|124517695 ankyrin repeat domain 36B [Homo sapiens] 456 e-128
gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Hom... 410 e-114
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 395 e-109
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 395 e-109
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 389 e-107
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 303 7e-82
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 303 1e-81
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 300 6e-81
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 300 6e-81
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 299 1e-80
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 297 7e-80
gi|50897294 POTE ankyrin domain family, member A isoform 1 [Homo... 268 3e-71
gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo... 250 7e-66
gi|134133226 protein expressed in prostate, ovary, testis, and p... 239 2e-62
gi|224282147 prostate-specific P704P [Homo sapiens] 237 6e-62
gi|153791352 prostate, ovary, testis expressed protein on chromo... 237 6e-62
gi|239747898 PREDICTED: actin, beta-like 3 [Homo sapiens] 236 1e-61
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 3336 bits (8649), Expect = 0.0
Identities = 1710/1710 (100%), Positives = 1710/1710 (100%)
Query: 1 MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVA 60
MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVA
Sbjct: 1 MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVA 60
Query: 61 KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA 120
KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA
Sbjct: 61 KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA 120
Query: 121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDL 180
VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDL
Sbjct: 121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDL 180
Query: 181 TPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDES 240
TPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDES
Sbjct: 181 TPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDES 240
Query: 241 SEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR 300
SEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR
Sbjct: 241 SEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR 300
Query: 301 TGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKE 360
TGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKE
Sbjct: 301 TGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKE 360
Query: 361 EPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW 420
EPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW
Sbjct: 361 EPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW 420
Query: 421 DSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNV 480
DSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNV
Sbjct: 421 DSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNV 480
Query: 481 GMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSE 540
GMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSE
Sbjct: 481 GMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSE 540
Query: 541 NNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN 600
NNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN
Sbjct: 541 NNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN 600
Query: 601 KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDE 660
KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDE
Sbjct: 601 KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDE 660
Query: 661 GRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECK 720
GRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECK
Sbjct: 661 GRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECK 720
Query: 721 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ 780
DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ
Sbjct: 721 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ 780
Query: 781 KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL 840
KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL
Sbjct: 781 KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL 840
Query: 841 EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN 900
EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN
Sbjct: 841 EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN 900
Query: 901 SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI 960
SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI
Sbjct: 901 SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI 960
Query: 961 KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR
Sbjct: 961 KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
Query: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF
Sbjct: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
Query: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ
Sbjct: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
Query: 1141 SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC 1200
SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC
Sbjct: 1141 SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC 1200
Query: 1201 NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLK 1260
NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLK
Sbjct: 1201 NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLK 1260
Query: 1261 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL 1320
KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL
Sbjct: 1261 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL 1320
Query: 1321 NANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1380
NANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG
Sbjct: 1321 NANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1380
Query: 1381 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTV 1440
EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTV
Sbjct: 1381 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTV 1440
Query: 1441 QKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1500
QKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF
Sbjct: 1441 QKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1500
Query: 1501 LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYL 1560
LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYL
Sbjct: 1501 LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYL 1560
Query: 1561 EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLD 1620
EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLD
Sbjct: 1561 EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLD 1620
Query: 1621 LNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPL 1680
LNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPL
Sbjct: 1621 LNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPL 1680
Query: 1681 GSTDESNLNQDLVWKASREYVQVLKKNYMI 1710
GSTDESNLNQDLVWKASREYVQVLKKNYMI
Sbjct: 1681 GSTDESNLNQDLVWKASREYVQVLKKNYMI 1710
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 723 bits (1866), Expect = 0.0
Identities = 532/1366 (38%), Positives = 745/1366 (54%), Gaps = 194/1366 (14%)
Query: 186 AVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSL 245
A SG + L V+ D+ +S QL+ EYKE++ P+ QN+N + +L
Sbjct: 88 ARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTL 147
Query: 246 SRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR----- 300
S D++ S ++L D K PS++ M +Q + K L T R
Sbjct: 148 S--------DETCQRS--KNLKVDDKC---PSVSPSMPENQSATKELGQMNLTEREKMDT 194
Query: 301 -----TGNRTLFE---------------DRDSDSQDEVVVESLPTTSIKVQCFSHPTYQS 340
+GN TL + ++DS+ E E L K T Q
Sbjct: 195 GVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGCENKQP---QKTSQE 251
Query: 341 PDLLPKPSHKSL----ANPGLMKEEPT--KPGIAKKENGIDI-----------------I 377
P++ + + P + K E + G + +N + + I
Sbjct: 252 PEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKI 311
Query: 378 ESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQK----- 432
+ P E+ DN T +V K+ ++ + + G EE+ S + E FP++
Sbjct: 312 PACPEEEPLLDNSTRGTDV-KDIPFNLTNNIP-GCEEEDASEISVSVVFETFPEQKEPSL 369
Query: 433 --YVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMP-VAHMES 489
+ P G ++++ C S S+ D N P + H+ S
Sbjct: 370 KNIIHPYYHPYSGSQEHV-------------CQSSSKFHLHENKLDCDNDNKPGIGHIFS 416
Query: 490 PERYLHLKPTIEMKDSVPNKAGGMKDV--QTSKAAEHDLEVASEEEQERE-GSENN---- 542
++ H D+ KA + V + + E DL++ Q + GS NN
Sbjct: 417 TDKNFH-------NDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSL 469
Query: 543 QPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKE 602
+P++E +++ +H+ D +QK K+ + E +
Sbjct: 470 KPKLENLSSLPPDSDRTSEVYLHEELQQD----------MQKFKN------EVNTLEEEF 513
Query: 603 YASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEG- 661
A +Q+ + E EK S + S +L G + DDD +I E
Sbjct: 514 LALKKEDVQLHKDVEEEMEKHRSNSTELS-----GTLTDGTTVGNDDDGLNQQIPRKENG 568
Query: 662 ---RPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGME 718
RP KTSNEKN+VKNQI D D + SE ASEDCEL HS Y+NFMLLIEQL ME
Sbjct: 569 EHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRME 628
Query: 719 CKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLE 778
KDS SL +IQD CE LL+LK NHC+ LTVK+K+ME+ V+VLQ ELSETK+ K QLE
Sbjct: 629 YKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLE 688
Query: 779 HQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQ 838
QK+EWE+EL LR +L QE E++RNAD LY K EQLR KEE+ K VE KQQL+ +L+
Sbjct: 689 LQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLR 748
Query: 839 TLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNS 898
L ELRTV++NL+ VVQERNDAQ+QLS EQ+AR+LQD ILT SKQKE+EMA+KKMNS
Sbjct: 749 RLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILT---SKQKELEMARKKMNS 805
Query: 899 ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQK 958
E SH H++EKDL H++ MLQEEIA+LRLEIDTIKNQN++KEKK FED++ VKEKN++LQK
Sbjct: 806 EISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQK 865
Query: 959 TIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIH 1018
IK NEETLT+TI QY+G+L+ LTAEN +LNS+LEN KQ++ERLE E+ESY RLAAA+
Sbjct: 866 IIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVR 925
Query: 1019 DRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1078
D DQS+T+ R+L+L FQR R E RL DKM D+S L+ NEILS++L ESK+NSL+I
Sbjct: 926 DCDQSQTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQI 984
Query: 1079 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ 1138
+ H+TRDAL ++L LERVQ+DLSQTQCQ KE EQ YQ EQ K+ KYI KQESVEERLSQ
Sbjct: 985 QLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQ 1044
Query: 1139 LQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELIS 1198
LQSENMLLRQQLDDAH KA+++EKT IQDQFH+ + LQAESEKQ L L+E+NKEL+
Sbjct: 1045 LQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMD 1104
Query: 1199 ECNHLKERQYQYENEKAEREVVVRQLQQ----------------ELADTLKKQSMSEASL 1242
E NHLKER Q E EKA R++ + + Q+ +L TL +
Sbjct: 1105 EYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQC 1164
Query: 1243 EVTSRYRINLEDETQDLKKKLGQIRNQLQ-----------------EAQDRHTEAVRCAE 1285
E + + L+ E +LK + RN L+ E +++ EA+ +
Sbjct: 1165 ETLQKNKKQLKQEVVNLKSYME--RNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQ 1222
Query: 1286 KMQ--DHKQ--KLEKDN-----AKLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKK 1334
K H+Q +L +DN ++++T+K +I ++ + + N +E E KE +
Sbjct: 1223 KQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKELYLE 1282
Query: 1335 LMELKQSLECNLDQ------EMKKNVELEREITGFKNLLK--MTRKKLNEYENGEFSFHG 1386
+++++SL L + E+ + +E+E T ++L TR L G +
Sbjct: 1283 EVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLNDSE 1342
Query: 1387 DL---------KTSQFEMDIQINKLKHKI-DDLTAELETAGSKCLH 1422
L +++ +M+ + K++ K+ +DLTAE+ + LH
Sbjct: 1343 GLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVAGSSQTGLH 1388
Score = 355 bits (910), Expect = 3e-97
Identities = 303/948 (31%), Positives = 469/948 (49%), Gaps = 133/948 (14%)
Query: 791 LRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSN 850
L L Q+ +K +N E+ L++++ Q K+VE + + S T EL ++
Sbjct: 491 LHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNST---ELSGTLTD 547
Query: 851 LNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEM---AQKKMNSENSHSHEEE 907
V + + +Q+ R++N + T++ + + ++ A + E S E+
Sbjct: 548 GTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASED 607
Query: 908 KDLSH---KNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE 964
+LSH +N ML I LR+E + + ++ C E L K +
Sbjct: 608 CELSHSVYENFMLL--IEQLRMEYKDSASLPRIQDTFCL---------CEHLLKLKNNHC 656
Query: 965 ETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE 1024
+ LT + Q +SVL +N + +K + +++E E E Y RLA Q
Sbjct: 657 DQLTVKLKQMENMVSVL--QNELSETKKTKLQLELQKIEWEKELYDLRLALK-----QEN 709
Query: 1025 TSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTR 1084
KR ++ + + ++ +++ V + L + + + + N+L++
Sbjct: 710 EEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN 769
Query: 1085 DALREKTLGLE---RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1141
DA +K L E R+ +D T Q KE+E + +++ K++ + LQ
Sbjct: 770 DA--QKQLSEEQDARILQDQILTSKQ-KELEMARKKMNSEISHRHQKEKDLFHEDCMLQE 826
Query: 1142 ENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLE--ERNKELISE 1199
E LLR ++D N+ KEK + ++A EK L + + N+E ++E
Sbjct: 827 EIALLRLEIDTIKNQNKQKEKKYF----------EDIEAVKEKNDNLQKIIKLNEETLTE 876
Query: 1200 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1259
+ + Q N AE +++ +L+ KQ+ +E+ S YR L +D
Sbjct: 877 T--ILQYSGQLNNLTAENKILNSELENG------KQNQERLEIEMES-YRCRLAAAVRDC 927
Query: 1260 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNL 1319
+ R+ + Q E VR +KM+ L+ N L + KI LQ L
Sbjct: 928 DQSQ-TARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQL 986
Query: 1320 LNAN-----------------------------LSEDEKEQLKKLMELKQSLECNLDQEM 1350
N + + E+ +LKK + ++S+E L Q
Sbjct: 987 HNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQ 1046
Query: 1351 KKNVELEREITGFKNLLKMTRKKLNEYENGEFS----FHGDLKTSQFEMDIQI------- 1399
+N+ L +++ KK N E + FH K Q E + QI
Sbjct: 1047 SENMLLRQQLDD-------AHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKN 1099
Query: 1400 -------NKLKHKID-----------DLTAELETAGSKCLHLDTKNQILQ--EELLSMKT 1439
N LK ++D DLT ET S+CLHLD +N++LQ + L SMK
Sbjct: 1100 KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKA 1159
Query: 1440 VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNL 1499
+QK+CE LQKNKK+L+QEV+NL+S++ERNM+E G+ + +K IEERAR+EI EKL E L
Sbjct: 1160 IQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAIL 1219
Query: 1500 FLQAQAA-SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQL 1558
LQ QAA S E L Q RE+N S+K+QMEL IKDLESE+S+IKTSQ DFNKTELE+YK+L
Sbjct: 1220 TLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
Query: 1559 YLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQ--SRSLFTTLTTRPVMEPPCVGNLN 1616
YLEE+KVR+SLS++L++TNE +AEV+T+L VEK+Q SRSLFT TRPV+E PCVGNLN
Sbjct: 1280 YLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLN 1339
Query: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITREL 1664
+S LNRK IPR+ R++ ME+YL KMQQ+L+ ++T E+
Sbjct: 1340 DSEGLNRKHIPRKK--------RSALKDMESYLLKMQQKLQNDLTAEV 1379
Score = 87.4 bits (215), Expect = 1e-16
Identities = 163/857 (19%), Positives = 348/857 (40%), Gaps = 124/857 (14%)
Query: 899 ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQK 958
+N H+ K + ++ E ++ KN NQ + + K +K K E+L
Sbjct: 419 KNFHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSS 478
Query: 959 TIKQNEET--------LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYH 1010
++ T L Q + ++ ++ T E L K E+ + K+ +E E+E +
Sbjct: 479 LPPDSDRTSEVYLHEELQQDMQKFKNEVN--TLEEEFLALKKEDVQLHKD-VEEEMEKHR 535
Query: 1011 S---------------------------RLAAAIHDRDQSETSKRELELAFQRARD---- 1039
S R HDR +TS + E+ Q +
Sbjct: 536 SNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFA 595
Query: 1040 ---ECSRLQDKMNFDVSNLKDNNEILSQQL---FKTESKLNSLEIEFHHTRDALREK--- 1090
E S + + ++ +N +L +QL +K + L ++ F L+ K
Sbjct: 596 DSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNH 655
Query: 1091 ----TLGLERVQKDLSQTQCQMKEMEQ-KYQNEQVKVN--------KYIGKQESVEERLS 1137
T+ L++++ +S Q ++ E ++ K Q E K+ + KQE+ E+R +
Sbjct: 656 CDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNA 715
Query: 1138 QL--QSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERN-- 1193
+ ++ LR + ++ + K++ N++ +V++L+ L+++ERN
Sbjct: 716 DMLYNKDSEQLRIKEEECGKVVETKQQLKWNLR----RLVKELRTVRNNLDLVVQERNDA 771
Query: 1194 -KELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINL 1252
K+L E + + +++ E E+ +++ E++ +K+ + L
Sbjct: 772 QKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE-------KDLFHEDCML 824
Query: 1253 EDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK-LKVTVKKQMDK 1311
++E L+ ++ I+NQ ++ + ++ E + ++ D+ QK+ K N + L T+ + +
Sbjct: 825 QEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQ 884
Query: 1312 IEEL--QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKM 1369
+ L + +LN+ L ++ Q + +E+ +S C L + ++ + + K +
Sbjct: 885 LNNLTAENKILNSELENGKQNQERLEIEM-ESYRCRLAAAV-RDCDQSQTARDLKLDFQR 942
Query: 1370 TRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC----LHLDT 1425
TR++ + +M + ++ L+ K + L+ +L A SK + L
Sbjct: 943 TRQEWVRLHD--------------KMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHN 988
Query: 1426 KNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEER 1485
L E L ++ VQ+ + Q KK+ EQ M ++ Q K K ++
Sbjct: 989 TRDALGRESLILERVQRDLSQTQCQKKETEQ------------MYQIEQSKLKKYIAKQE 1036
Query: 1486 ARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQE 1545
+ +E +L+ N+ L+ Q +E ++++ Q K+L++E K S +
Sbjct: 1037 SVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQ 1096
Query: 1546 DFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKL--LVEKQQSRSLFTTLTT 1603
+ NK +++Y L + K + + E V ++ L + + L TL +
Sbjct: 1097 EKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFS 1156
Query: 1604 RPVMEPPCVGNLNNSLDLNRKLIPRE--NLVISTSNPRASNNSMENYLSKMQQELEKNIT 1661
++ C +L N+K + +E NL E + +++ K I
Sbjct: 1157 MKAIQKQC-----ETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIE 1211
Query: 1662 RELKEAAAELESGSIAS 1678
+L EA L+ + S
Sbjct: 1212 EKLNEAILTLQKQAAVS 1228
Score = 50.1 bits (118), Expect = 2e-05
Identities = 24/58 (41%), Positives = 37/58 (63%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDK 78
++S G + GEGA QP + VR DLG++H+AA +G+V V+ IL G++ RD+
Sbjct: 55 KNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDR 112
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 600 bits (1547), Expect = e-171
Identities = 356/758 (46%), Positives = 478/758 (63%), Gaps = 118/758 (15%)
Query: 514 KDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDA 572
K +Q S + E DLE+ SE EQER EG E++QPQVEE+ KK RN +MEVS N+H A D
Sbjct: 266 KSLQNSNS-EQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVH--ADDSD 322
Query: 573 EDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSP 632
+DD D LI K K+ + D+ Q P KEN E+ ++ S EK K S+
Sbjct: 323 NYNDDVDELIHKIKNRKPDNHQSPGKENGEFD------RLARKTSNEKSKVKSQ------ 370
Query: 633 VFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSE 692
I DD++D++ SSE
Sbjct: 371 ---------------------------------------------IYFTDDLNDISGSSE 385
Query: 693 TASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVK 752
SED ELP+S +NFMLLI+Q GMECKD VSL K ++A +C R +E +K +CE L VK
Sbjct: 386 KTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCERLKVK 445
Query: 753 IKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKI 812
+KM++ ++VLQ+ LSET + KSQ EHQ ++ +++LC+LRF L Q+EE+R A+ LYEK
Sbjct: 446 FQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKD 505
Query: 813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR 872
E+L+ EEQYR + EVK+Q +L+L++LE+EL+TV+SN NQ
Sbjct: 506 IEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQ------------------- 546
Query: 873 MLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIK 932
N H+HE E+DL +N ++++EIA LRLEIDTIK
Sbjct: 547 ---------------------------NFHTHERERDLWQENHLMRDEIARLRLEIDTIK 579
Query: 933 NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL 992
+QNQE E K F+D++I+KE NEDL+KT+K+NEETLT+TI++Y+ L+VL EN MLNS+L
Sbjct: 580 HQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSEL 639
Query: 993 ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV 1052
+ EKQS RLE E+ESY RLAAA+ D DQ ++SKR+L+LAFQ +E LQ+ N +
Sbjct: 640 QKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHI 699
Query: 1053 SNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEME 1112
+ILSQQL K ES + LE E H+ R+AL+EKTL +E +Q LS+TQ +++++E
Sbjct: 700 -------QILSQQLSKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIE 752
Query: 1113 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFH 1172
YQN+Q + KY+ KQ+SVE+ L QLQS+N+L +QQ +DA KADN+EKT+INIQ +
Sbjct: 753 HMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCE 812
Query: 1173 AIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1232
V+KLQAE K LEE NK L+ EC LKERQ QYE EK EREVV RQLQ+E+ D L
Sbjct: 813 DTVEKLQAECRK----LEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDAL 868
Query: 1233 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQL 1270
KQ + EA LE++S RINLEDE Q LKKKLGQ+R+Q+
Sbjct: 869 NKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQV 906
Score = 251 bits (641), Expect = 4e-66
Identities = 261/1009 (25%), Positives = 443/1009 (43%), Gaps = 189/1009 (18%)
Query: 14 GSF--ARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKN 71
GSF A R+R + +G +S PGY VR +DLG IHKAA AG+V KV + +LLR N
Sbjct: 5 GSFLAACRRRMATWRKNRDKDG-FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLN 63
Query: 72 GLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
LNDRDK NRTAL LACA+G P VV LV RKCQLN+ D+ENRTAL+KAVQCQEE CA+I
Sbjct: 64 DLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASI 123
Query: 132 LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKK 191
LLEHGA+PN+ D++GNTALHYA+ NE+IS+A KLL Y A+IEA+++D T LLLAV+ KK
Sbjct: 124 LLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKK 183
Query: 192 QQMVEFLIKKKANVNAVD------------------------------------------ 209
+QMV FL+KKK ++ A+D
Sbjct: 184 EQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDY 243
Query: 210 ----KLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDED 265
K ++ +ISEYK + K S QNSNS + S G + S P +++
Sbjct: 244 AVASKFQAIRGMISEYKANKRRK-SLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEK- 301
Query: 266 LNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPT 325
+ K + +N+ A DSD+ ++ V E +
Sbjct: 302 ------------MKKCRNKKMEVSRNVHAD---------------DSDNYNDDVDELIH- 333
Query: 326 TSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENG-IDIIESAPLEQ 384
K++ +QSP KENG D + +
Sbjct: 334 ---KIKNRKPDNHQSPG---------------------------KENGEFDRL----ARK 359
Query: 385 TNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW-DSESISENFPQKYVDPLAGAADG 443
T+N+ +++ + + +S ED E P+ D E+ Q ++ +
Sbjct: 360 TSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLS 419
Query: 444 KEKNIG---NEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPV-------------AHM 487
K KN ED C K K+++ +V V ++
Sbjct: 420 KSKNATAACGRSIED----QKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNL 475
Query: 488 ESPERYLHLKPTIEMKDSVPNKAGGM--KDVQTSKAAEHDLEVASEEEQEREGSENNQPQ 545
+ ++ +L+ ++ ++ KA + KD++ K E +E +++ S+
Sbjct: 476 QGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQ---SKLTLKS 532
Query: 546 VEEERKKHRNNEMEVSANIHDGATDDAEDDD-DDDGLIQKRKSGETDHQQFPRKENKEYA 604
+E E K R+N + + + H+ D +++ D + + R +T Q ENK +
Sbjct: 533 LEVELKTVRSNSNQ-NFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFK 591
Query: 605 SSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPT 664
+ E EK + ++E++ + + L + +D+++ L+ + E +
Sbjct: 592 DIEIIKENNE--DLEKTLKRNEETLTKTITRYSKELN---VLMDENTMLNSELQKEKQSM 646
Query: 665 KKTSNEKNKVKNQIQSMDDVDDLTQSSE---------TASEDCELPHSSYKNFMLLIEQL 715
+ E + ++ + D QSS+ T +E C L + + +L +QL
Sbjct: 647 SRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQL 706
Query: 716 GMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS 775
K + + E L ++ + T+ I+ M+ ++ QR L + + +
Sbjct: 707 S----------KAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQ 756
Query: 776 QLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKE-VEVKQQLE 834
+ ++ R+ S+ L Q + + + LY++ R+K + K + ++ + E
Sbjct: 757 NDQPILEKYVRKQQSVEDGLFQLQSQ----NLLYQQQCNDARKKADNQEKTIINIQVKCE 812
Query: 835 LSLQTLEMELRTVKSN------------LNQVVQERNDAQRQLSREQNARMLQDGILTNH 882
+++ L+ E R ++ N Q E+ +R++ R Q R + D
Sbjct: 813 DTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDA----- 867
Query: 883 LSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTI 931
L+KQ +E + + + +E + L K ++ ++ M +L + T+
Sbjct: 868 LNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQVCM-KLSMSTV 915
Score = 68.2 bits (165), Expect = 7e-11
Identities = 98/509 (19%), Positives = 211/509 (41%), Gaps = 72/509 (14%)
Query: 886 QKEIEMAQKKMN-SENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFE 944
+ I + QK ++ ++ + S E ++L K + + + E + IK + E +K E
Sbjct: 450 KNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAE--ELYEKDIE 507
Query: 945 DLKIVKEK-------NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSK-LENEK 996
+LKI++E+ + + T+K E L S N E + L ++
Sbjct: 508 ELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDE 567
Query: 997 QSKERLEAEVESYHSRLAAAIHDRDQS--ETSKRELELAFQRARDECSRLQDKMNFDVSN 1054
++ RLE + + ++ + +D + + +LE +R + ++ + + +++
Sbjct: 568 IARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYSKELNV 627
Query: 1055 LKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1114
L D N +L+ +L K + ++ LE E R L D Q Q ++++
Sbjct: 628 LMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALC-------DHDQRQSSKRDLQLA 680
Query: 1115 YQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAI 1174
+Q+ VN++ QE + +L QQL A E T ++ + H
Sbjct: 681 FQST---VNEWCHLQEDTNSHIQ-------ILSQQLSKA-------ESTSSGLETELH-- 721
Query: 1175 VQKLQAESEKQSLLLEERNKELISECNH-LKERQYQYENEKAEREVVVRQLQQELADTLK 1233
+ E+ K+ L E + ++S L++ ++ Y+N++ E VR K
Sbjct: 722 ---YEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVR----------K 768
Query: 1234 KQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQK 1293
+QS+ + ++ S+ + + + D +KK A ++ + K +D +K
Sbjct: 769 QQSVEDGLFQLQSQ-NLLYQQQCNDARKK----------ADNQEKTIINIQVKCEDTVEK 817
Query: 1294 LEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS--------LECN 1345
L+ + KL+ K M + L++ ++E+E +++ ++ + LE
Sbjct: 818 LQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAM 877
Query: 1346 LDQEMKKNVELEREITGFKNLLKMTRKKL 1374
L+ ++ + LE E K L R ++
Sbjct: 878 LEISSERRINLEDEAQSLKKKLGQMRSQV 906
Score = 67.8 bits (164), Expect = 9e-11
Identities = 129/694 (18%), Positives = 288/694 (41%), Gaps = 92/694 (13%)
Query: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLE-IDTIKNQNQEKEKKCFEDL 946
E + +++ + +NS+S E+DL + QE RLE ++ + Q +EK KKC
Sbjct: 258 EYKANKRRKSLQNSNS---EQDLEMTSEGEQE-----RLEGCESSQPQVEEKMKKC---- 305
Query: 947 KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN------EKQSKE 1000
+ K ++ + + ++ YN + L + + N K +N E +
Sbjct: 306 ---RNKKMEVSRNVHADDS------DNYNDDVDELI--HKIKNRKPDNHQSPGKENGEFD 354
Query: 1001 RLEAEVESYHSRLAAAIHDRDQ-------SETSKRELELAFQRARD-----ECSRLQDKM 1048
RL + + S++ + I+ D SE + + EL + + + S ++ K
Sbjct: 355 RLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKD 414
Query: 1049 NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQ--- 1105
+S K+ + + + L+++F ++ + L K SQ++
Sbjct: 415 FVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQN 474
Query: 1106 -------CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAD 1158
C ++ + Q+ + E++K + K + + + +++Q +
Sbjct: 475 LQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLE 534
Query: 1159 NKEKTV-INIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
+ KTV N FH + + + +++ L+ + L E + +K + + EN+ +
Sbjct: 535 VELKTVRSNSNQNFHT--HERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKD 592
Query: 1218 EVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE---DETQDLKKKLGQIRNQLQEAQ 1274
++++ ++L TLK+ E + +RY L DE L +L Q Q
Sbjct: 593 IEIIKENNEDLEKTLKRNE--ETLTKTITRYSKELNVLMDENTMLNSEL-QKEKQSMSRL 649
Query: 1275 DRHTEAVRC--AEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332
+ E+ RC A + DH Q+ + L++ + +++ LQ++ N+++ + +QL
Sbjct: 650 ETEMESYRCRLAAALCDHDQR-QSSKRDLQLAFQSTVNEWCHLQEDT-NSHI-QILSQQL 706
Query: 1333 KKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE----YENGEFSFHGDL 1388
K LE L E + E I + +L T+++L + Y+N + +
Sbjct: 707 SKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYV 766
Query: 1389 KTSQ------FEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQK 1442
+ Q F++ Q + + +D + + +++ K + E+L Q
Sbjct: 767 RKQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKL------QA 820
Query: 1443 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKE---VNL 1499
+C KL++N K L +E L+ + + K+ ++ + + ++E+ + L + +
Sbjct: 821 ECRKLEENNKGLMKECTLLK----ERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEA 876
Query: 1500 FLQAQAASQENLE---QFRENNFASMKSQMELRI 1530
L+ + + NLE Q + M+SQ+ +++
Sbjct: 877 MLEISSERRINLEDEAQSLKKKLGQMRSQVCMKL 910
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 600 bits (1547), Expect = e-171
Identities = 356/758 (46%), Positives = 478/758 (63%), Gaps = 118/758 (15%)
Query: 514 KDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDA 572
K +Q S + E DLE+ SE EQER EG E++QPQVEE+ KK RN +MEVS N+H A D
Sbjct: 266 KSLQNSNS-EQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVH--ADDSD 322
Query: 573 EDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSP 632
+DD D LI K K+ + D+ Q P KEN E+ ++ S EK K S+
Sbjct: 323 NYNDDVDELIHKIKNRKPDNHQSPGKENGEFD------RLARKTSNEKSKVKSQ------ 370
Query: 633 VFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSE 692
I DD++D++ SSE
Sbjct: 371 ---------------------------------------------IYFTDDLNDISGSSE 385
Query: 693 TASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVK 752
SED ELP+S +NFMLLI+Q GMECKD VSL K ++A +C R +E +K +CE L VK
Sbjct: 386 KTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCERLKVK 445
Query: 753 IKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKI 812
+KM++ ++VLQ+ LSET + KSQ EHQ ++ +++LC+LRF L Q+EE+R A+ LYEK
Sbjct: 446 FQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKD 505
Query: 813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR 872
E+L+ EEQYR + EVK+Q +L+L++LE+EL+TV+SN NQ
Sbjct: 506 IEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQ------------------- 546
Query: 873 MLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIK 932
N H+HE E+DL +N ++++EIA LRLEIDTIK
Sbjct: 547 ---------------------------NFHTHERERDLWQENHLMRDEIARLRLEIDTIK 579
Query: 933 NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL 992
+QNQE E K F+D++I+KE NEDL+KT+K+NEETLT+TI++Y+ L+VL EN MLNS+L
Sbjct: 580 HQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSEL 639
Query: 993 ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV 1052
+ EKQS RLE E+ESY RLAAA+ D DQ ++SKR+L+LAFQ +E LQ+ N +
Sbjct: 640 QKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHI 699
Query: 1053 SNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEME 1112
+ILSQQL K ES + LE E H+ R+AL+EKTL +E +Q LS+TQ +++++E
Sbjct: 700 -------QILSQQLSKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIE 752
Query: 1113 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFH 1172
YQN+Q + KY+ KQ+SVE+ L QLQS+N+L +QQ +DA KADN+EKT+INIQ +
Sbjct: 753 HMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCE 812
Query: 1173 AIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1232
V+KLQAE K LEE NK L+ EC LKERQ QYE EK EREVV RQLQ+E+ D L
Sbjct: 813 DTVEKLQAECRK----LEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDAL 868
Query: 1233 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQL 1270
KQ + EA LE++S RINLEDE Q LKKKLGQ+R+Q+
Sbjct: 869 NKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQV 906
Score = 251 bits (641), Expect = 4e-66
Identities = 261/1009 (25%), Positives = 443/1009 (43%), Gaps = 189/1009 (18%)
Query: 14 GSF--ARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKN 71
GSF A R+R + +G +S PGY VR +DLG IHKAA AG+V KV + +LLR N
Sbjct: 5 GSFLAACRRRMATWRKNRDKDG-FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLN 63
Query: 72 GLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
LNDRDK NRTAL LACA+G P VV LV RKCQLN+ D+ENRTAL+KAVQCQEE CA+I
Sbjct: 64 DLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASI 123
Query: 132 LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKK 191
LLEHGA+PN+ D++GNTALHYA+ NE+IS+A KLL Y A+IEA+++D T LLLAV+ KK
Sbjct: 124 LLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKK 183
Query: 192 QQMVEFLIKKKANVNAVD------------------------------------------ 209
+QMV FL+KKK ++ A+D
Sbjct: 184 EQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDY 243
Query: 210 ----KLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDED 265
K ++ +ISEYK + K S QNSNS + S G + S P +++
Sbjct: 244 AVASKFQAIRGMISEYKANKRRK-SLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEK- 301
Query: 266 LNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPT 325
+ K + +N+ A DSD+ ++ V E +
Sbjct: 302 ------------MKKCRNKKMEVSRNVHAD---------------DSDNYNDDVDELIH- 333
Query: 326 TSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENG-IDIIESAPLEQ 384
K++ +QSP KENG D + +
Sbjct: 334 ---KIKNRKPDNHQSPG---------------------------KENGEFDRL----ARK 359
Query: 385 TNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW-DSESISENFPQKYVDPLAGAADG 443
T+N+ +++ + + +S ED E P+ D E+ Q ++ +
Sbjct: 360 TSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLS 419
Query: 444 KEKNIG---NEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPV-------------AHM 487
K KN ED C K K+++ +V V ++
Sbjct: 420 KSKNATAACGRSIED----QKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNL 475
Query: 488 ESPERYLHLKPTIEMKDSVPNKAGGM--KDVQTSKAAEHDLEVASEEEQEREGSENNQPQ 545
+ ++ +L+ ++ ++ KA + KD++ K E +E +++ S+
Sbjct: 476 QGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQ---SKLTLKS 532
Query: 546 VEEERKKHRNNEMEVSANIHDGATDDAEDDD-DDDGLIQKRKSGETDHQQFPRKENKEYA 604
+E E K R+N + + + H+ D +++ D + + R +T Q ENK +
Sbjct: 533 LEVELKTVRSNSNQ-NFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFK 591
Query: 605 SSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPT 664
+ E EK + ++E++ + + L + +D+++ L+ + E +
Sbjct: 592 DIEIIKENNE--DLEKTLKRNEETLTKTITRYSKELN---VLMDENTMLNSELQKEKQSM 646
Query: 665 KKTSNEKNKVKNQIQSMDDVDDLTQSSE---------TASEDCELPHSSYKNFMLLIEQL 715
+ E + ++ + D QSS+ T +E C L + + +L +QL
Sbjct: 647 SRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQL 706
Query: 716 GMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS 775
K + + E L ++ + T+ I+ M+ ++ QR L + + +
Sbjct: 707 S----------KAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQ 756
Query: 776 QLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKE-VEVKQQLE 834
+ ++ R+ S+ L Q + + + LY++ R+K + K + ++ + E
Sbjct: 757 NDQPILEKYVRKQQSVEDGLFQLQSQ----NLLYQQQCNDARKKADNQEKTIINIQVKCE 812
Query: 835 LSLQTLEMELRTVKSN------------LNQVVQERNDAQRQLSREQNARMLQDGILTNH 882
+++ L+ E R ++ N Q E+ +R++ R Q R + D
Sbjct: 813 DTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDA----- 867
Query: 883 LSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTI 931
L+KQ +E + + + +E + L K ++ ++ M +L + T+
Sbjct: 868 LNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQVCM-KLSMSTV 915
Score = 68.2 bits (165), Expect = 7e-11
Identities = 98/509 (19%), Positives = 211/509 (41%), Gaps = 72/509 (14%)
Query: 886 QKEIEMAQKKMN-SENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFE 944
+ I + QK ++ ++ + S E ++L K + + + E + IK + E +K E
Sbjct: 450 KNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAE--ELYEKDIE 507
Query: 945 DLKIVKEK-------NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSK-LENEK 996
+LKI++E+ + + T+K E L S N E + L ++
Sbjct: 508 ELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDE 567
Query: 997 QSKERLEAEVESYHSRLAAAIHDRDQS--ETSKRELELAFQRARDECSRLQDKMNFDVSN 1054
++ RLE + + ++ + +D + + +LE +R + ++ + + +++
Sbjct: 568 IARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYSKELNV 627
Query: 1055 LKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1114
L D N +L+ +L K + ++ LE E R L D Q Q ++++
Sbjct: 628 LMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALC-------DHDQRQSSKRDLQLA 680
Query: 1115 YQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAI 1174
+Q+ VN++ QE + +L QQL A E T ++ + H
Sbjct: 681 FQST---VNEWCHLQEDTNSHIQ-------ILSQQLSKA-------ESTSSGLETELH-- 721
Query: 1175 VQKLQAESEKQSLLLEERNKELISECNH-LKERQYQYENEKAEREVVVRQLQQELADTLK 1233
+ E+ K+ L E + ++S L++ ++ Y+N++ E VR K
Sbjct: 722 ---YEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVR----------K 768
Query: 1234 KQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQK 1293
+QS+ + ++ S+ + + + D +KK A ++ + K +D +K
Sbjct: 769 QQSVEDGLFQLQSQ-NLLYQQQCNDARKK----------ADNQEKTIINIQVKCEDTVEK 817
Query: 1294 LEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS--------LECN 1345
L+ + KL+ K M + L++ ++E+E +++ ++ + LE
Sbjct: 818 LQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAM 877
Query: 1346 LDQEMKKNVELEREITGFKNLLKMTRKKL 1374
L+ ++ + LE E K L R ++
Sbjct: 878 LEISSERRINLEDEAQSLKKKLGQMRSQV 906
Score = 67.8 bits (164), Expect = 9e-11
Identities = 129/694 (18%), Positives = 288/694 (41%), Gaps = 92/694 (13%)
Query: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLE-IDTIKNQNQEKEKKCFEDL 946
E + +++ + +NS+S E+DL + QE RLE ++ + Q +EK KKC
Sbjct: 258 EYKANKRRKSLQNSNS---EQDLEMTSEGEQE-----RLEGCESSQPQVEEKMKKC---- 305
Query: 947 KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN------EKQSKE 1000
+ K ++ + + ++ YN + L + + N K +N E +
Sbjct: 306 ---RNKKMEVSRNVHADDS------DNYNDDVDELI--HKIKNRKPDNHQSPGKENGEFD 354
Query: 1001 RLEAEVESYHSRLAAAIHDRDQ-------SETSKRELELAFQRARD-----ECSRLQDKM 1048
RL + + S++ + I+ D SE + + EL + + + S ++ K
Sbjct: 355 RLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKD 414
Query: 1049 NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQ--- 1105
+S K+ + + + L+++F ++ + L K SQ++
Sbjct: 415 FVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQN 474
Query: 1106 -------CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAD 1158
C ++ + Q+ + E++K + K + + + +++Q +
Sbjct: 475 LQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLE 534
Query: 1159 NKEKTV-INIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
+ KTV N FH + + + +++ L+ + L E + +K + + EN+ +
Sbjct: 535 VELKTVRSNSNQNFHT--HERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKD 592
Query: 1218 EVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE---DETQDLKKKLGQIRNQLQEAQ 1274
++++ ++L TLK+ E + +RY L DE L +L Q Q
Sbjct: 593 IEIIKENNEDLEKTLKRNE--ETLTKTITRYSKELNVLMDENTMLNSEL-QKEKQSMSRL 649
Query: 1275 DRHTEAVRC--AEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332
+ E+ RC A + DH Q+ + L++ + +++ LQ++ N+++ + +QL
Sbjct: 650 ETEMESYRCRLAAALCDHDQR-QSSKRDLQLAFQSTVNEWCHLQEDT-NSHI-QILSQQL 706
Query: 1333 KKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE----YENGEFSFHGDL 1388
K LE L E + E I + +L T+++L + Y+N + +
Sbjct: 707 SKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYV 766
Query: 1389 KTSQ------FEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQK 1442
+ Q F++ Q + + +D + + +++ K + E+L Q
Sbjct: 767 RKQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKL------QA 820
Query: 1443 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKE---VNL 1499
+C KL++N K L +E L+ + + K+ ++ + + ++E+ + L + +
Sbjct: 821 ECRKLEENNKGLMKECTLLK----ERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEA 876
Query: 1500 FLQAQAASQENLE---QFRENNFASMKSQMELRI 1530
L+ + + NLE Q + M+SQ+ +++
Sbjct: 877 MLEISSERRINLEDEAQSLKKKLGQMRSQVCMKL 910
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 600 bits (1546), Expect = e-171
Identities = 356/758 (46%), Positives = 477/758 (62%), Gaps = 118/758 (15%)
Query: 514 KDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDA 572
K +Q S + E DLE+ SE EQER EG E++QPQVEE+ KK RN +MEVS N+H A D
Sbjct: 266 KSLQNSNS-EQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVH--ADDSD 322
Query: 573 EDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSP 632
+DD D LI K K+ + D+ Q P KEN E+ ++ S EK K S+
Sbjct: 323 NYNDDVDELIHKIKNRKPDNHQSPGKENGEFD------RLARKTSNEKSKVKSQ------ 370
Query: 633 VFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSE 692
I DD++D++ SSE
Sbjct: 371 ---------------------------------------------IYFTDDLNDISGSSE 385
Query: 693 TASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVK 752
SED ELP+S +NFMLLIEQ GMECKD VSL K ++A +C R +E +K +CE L VK
Sbjct: 386 KTSEDDELPYSDDENFMLLIEQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCERLKVK 445
Query: 753 IKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKI 812
+KM++ ++VLQ+ LSET + KSQ EHQ ++ +++LC+LRF L Q+EE+R A+ LYEK
Sbjct: 446 FQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKD 505
Query: 813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR 872
E+L+ EEQYR + EVK+Q +L+L++LE+EL+TV+SN NQ
Sbjct: 506 IEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQ------------------- 546
Query: 873 MLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIK 932
N H+HE E+DL +N ++++EIA LRLEIDTIK
Sbjct: 547 ---------------------------NFHTHERERDLWQENHLMRDEIARLRLEIDTIK 579
Query: 933 NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL 992
+QNQE E K F+D++I+KE NEDL+KT+K+NEE LT+TI++Y+ L+VL EN MLNS+L
Sbjct: 580 HQNQETENKYFKDIEIIKENNEDLEKTLKRNEEALTKTITRYSKELNVLMDENTMLNSEL 639
Query: 993 ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV 1052
+ EKQS RLE E+ESY RLAAA+ D DQ ++SKR+L+LAFQ +E LQ+ N +
Sbjct: 640 QKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHI 699
Query: 1053 SNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEME 1112
+ILSQQL K ES + LE E H+ R+AL+EKTL +E +Q LS+TQ +++++E
Sbjct: 700 -------QILSQQLSKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIE 752
Query: 1113 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFH 1172
YQN+Q + KY+ KQ+SVE+ L QLQS+N+L +QQ +DA KADN+EKT+INIQ +
Sbjct: 753 HMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCE 812
Query: 1173 AIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1232
V+KLQAE K LEE NK L+ EC LKERQ QYE EK EREVV RQLQ+E+ D L
Sbjct: 813 DTVEKLQAECRK----LEENNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDAL 868
Query: 1233 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQL 1270
KQ + EA LE++S RINLEDE Q LKKKLGQ+R+Q+
Sbjct: 869 NKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQV 906
Score = 250 bits (639), Expect = 7e-66
Identities = 262/993 (26%), Positives = 445/993 (44%), Gaps = 157/993 (15%)
Query: 14 GSF--ARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKN 71
GSF A R+R + +G +S PGY VR +DLG IHKAA AG+V KV + +LLR N
Sbjct: 5 GSFLAACRRRMATWRKNRDKDG-FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLN 63
Query: 72 GLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
LNDRDK NRTAL LACA+G P VV LV RKCQLN+ D+ENRTAL+KAVQCQEE CA+I
Sbjct: 64 DLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASI 123
Query: 132 LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKK 191
LLEHGA+PN+ D++GNTALHYA+ NE+IS+A KLL Y A+IEA+++D T LLLAV+ KK
Sbjct: 124 LLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKK 183
Query: 192 QQMVEFLIKKKANVNAVD------------------------------------------ 209
+QMV FL+KKK ++ A+D
Sbjct: 184 EQMVAFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDY 243
Query: 210 ----KLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDED 265
K ++ +ISEYK + K S QNSNS + S G + S P +++
Sbjct: 244 AVASKFQAIRGMISEYKANKRCK-SLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEK- 301
Query: 266 LNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPT 325
+ K + +N+ A DSD+ ++ V E +
Sbjct: 302 ------------MKKCRNKKMEVSRNVHAD---------------DSDNYNDDVDELIH- 333
Query: 326 TSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQT 385
K++ +QSP LA ++ K I ++ DI S+ + +
Sbjct: 334 ---KIKNRKPDNHQSPG-KENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSSE-KTS 388
Query: 386 NNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKE 445
+D L Y D+ N ++ G+ ++ + S S S+N A AA G+
Sbjct: 389 EDDELPYSDD---ENFMLLIEQSGMECKDFV-----SLSKSKN---------ATAACGRS 431
Query: 446 KNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAH--MESPERYLHLKPTIEMK 503
E + M + + L +T H ++ ++ +L+ ++ +
Sbjct: 432 IEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQ 491
Query: 504 DSVPNKAGGM--KDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVS 561
+ KA + KD++ K E +E +++ S+ +E E K R+N + +
Sbjct: 492 EEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQ---SKLTLKSLEVELKTVRSNSNQ-N 547
Query: 562 ANIHDGATDDAEDDD-DDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEK 620
+ H+ D +++ D + + R +T Q ENK + + E EK
Sbjct: 548 FHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNE--DLEK 605
Query: 621 EKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQS 680
+ ++E++ + + L + +D+++ L+ + E + + E + ++ +
Sbjct: 606 TLKRNEEALTKTITRYSKELN---VLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAA 662
Query: 681 MDDVDDLTQSSE---------TASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDA 731
D QSS+ T +E C L + + +L +QL K +
Sbjct: 663 ALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLS----------KAEST 712
Query: 732 ALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSL 791
+ E L ++ + T+ I+ M+ ++ QR L + + + + ++ R+ S+
Sbjct: 713 SSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSV 772
Query: 792 RFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKE-VEVKQQLELSLQTLEMELRTVKSN 850
L Q + + + LY++ R+K + K + ++ + E +++ L+ E R ++ N
Sbjct: 773 EDGLFQLQSQ----NLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEEN 828
Query: 851 ------------LNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNS 898
Q E+ +R++ R Q R + D L+KQ +E + +
Sbjct: 829 NKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDA-----LNKQLLLEAMLEISSE 883
Query: 899 ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTI 931
+ +E + L K ++ ++ M +L + T+
Sbjct: 884 RRINLEDEAQSLKKKLGQMRSQVCM-KLSMSTV 915
Score = 69.7 bits (169), Expect = 2e-11
Identities = 133/691 (19%), Positives = 287/691 (41%), Gaps = 93/691 (13%)
Query: 892 AQKKMNS-ENSHSHEEEKDLSHKNSMLQEEIAMLRLE-IDTIKNQNQEKEKKCFEDLKIV 949
A K+ S +NS+S E+DL + QE RLE ++ + Q +EK KKC
Sbjct: 261 ANKRCKSLQNSNS---EQDLEMTSEGEQE-----RLEGCESSQPQVEEKMKKC------- 305
Query: 950 KEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN------EKQSKERLE 1003
+ K ++ + + ++ YN + L + + N K +N E +RL
Sbjct: 306 RNKKMEVSRNVHADDS------DNYNDDVDELI--HKIKNRKPDNHQSPGKENGEFDRLA 357
Query: 1004 AEVESYHSRLAAAIHDRDQ-------SETSKRELELAFQRARD-----ECSRLQDKMNFD 1051
+ + S++ + I+ D SE + + EL + + E S ++ K
Sbjct: 358 RKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIEQSGMECKDFVS 417
Query: 1052 VSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQ------ 1105
+S K+ + + + L+++F ++ + L K SQ++
Sbjct: 418 LSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQG 477
Query: 1106 ----CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKE 1161
C ++ + Q+ + E++K + K + + + +++Q + +
Sbjct: 478 KKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVEL 537
Query: 1162 KTV-INIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVV 1220
KTV N FH + + + +++ L+ + L E + +K + + EN+ + +
Sbjct: 538 KTVRSNSNQNFHT--HERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEI 595
Query: 1221 VRQLQQELADTLKKQSMSEASLEVTSRYRINLE---DETQDLKKKLGQIRNQLQEAQDRH 1277
+++ ++L TLK+ EA + +RY L DE L +L Q Q +
Sbjct: 596 IKENNEDLEKTLKRNE--EALTKTITRYSKELNVLMDENTMLNSEL-QKEKQSMSRLETE 652
Query: 1278 TEAVRC--AEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1335
E+ RC A + DH Q+ + L++ + +++ LQ++ N+++ + +QL K
Sbjct: 653 MESYRCRLAAALCDHDQR-QSSKRDLQLAFQSTVNEWCHLQEDT-NSHI-QILSQQLSKA 709
Query: 1336 MELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE----YENGEFSFHGDLKTS 1391
LE L E + E I + +L T+++L + Y+N + ++
Sbjct: 710 ESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQ 769
Query: 1392 Q------FEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE 1445
Q F++ Q + + +D + + +++ K + E+L Q +C
Sbjct: 770 QSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKL------QAECR 823
Query: 1446 KLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKE---VNLFLQ 1502
KL++N K L +E L+ + + K+ ++ + + ++E+ + L + + L+
Sbjct: 824 KLEENNKGLMKECTLLK----ERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLE 879
Query: 1503 AQAASQENLE---QFRENNFASMKSQMELRI 1530
+ + NLE Q + M+SQ+ +++
Sbjct: 880 ISSERRINLEDEAQSLKKKLGQMRSQVCMKL 910
Score = 68.6 bits (166), Expect = 5e-11
Identities = 118/591 (19%), Positives = 247/591 (41%), Gaps = 68/591 (11%)
Query: 814 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARM 873
++L RK + +V K Q+ + ++ + K++ + + +D L EQ+
Sbjct: 354 DRLARKTSNEKSKV--KSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIEQSGME 411
Query: 874 LQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEK----DLSHKNSMLQEEIAMLRLEID 929
+D + LSK K A + + E K + + S+LQ+ ++ E D
Sbjct: 412 CKDFV---SLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLS----ETD 464
Query: 930 TIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN 989
K+Q++ + + K+K +L+ ++Q EE + Y + L
Sbjct: 465 KTKSQSEHQNLQG-------KKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYR 517
Query: 990 SKLENEKQSK---ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1046
++ E +KQSK + LE E+++ S H ++ +E L RDE +RL+
Sbjct: 518 TQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLM----RDEIARLR- 572
Query: 1047 KMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQC 1106
++ +K N+ + FK +IE + EKTL +R ++ L++T
Sbjct: 573 ---LEIDTIKHQNQETENKYFK--------DIEIIKENNEDLEKTL--KRNEEALTKTIT 619
Query: 1107 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1166
+ + +E +N + K++ + +S+L++E R +L A D ++ + +
Sbjct: 620 RYSKELNVLMDENTMLNSELQKEK---QSMSRLETEMESYRCRLAAALCDHDQRQSSKRD 676
Query: 1167 IQDQFHAIVQK---LQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREV---- 1219
+Q F + V + LQ ++ +L ++ + S + L E + YE E + +
Sbjct: 677 LQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSSGL-ETELHYEREALKEKTLHIE 735
Query: 1220 ----VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKK----LGQIRNQLQ 1271
V+ + Q+ L D + LE R + ++ED L+ + Q + +
Sbjct: 736 HMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDARK 795
Query: 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1331
+A ++ + K +D +KL+ + KL+ K M + L++ ++E+E
Sbjct: 796 KADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREV 855
Query: 1332 LKKLMELKQS--------LECNLDQEMKKNVELEREITGFKNLLKMTRKKL 1374
+++ ++ + LE L+ ++ + LE E K L R ++
Sbjct: 856 VRRQLQREVDDALNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQV 906
>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 1430
Score = 567 bits (1462), Expect = e-161
Identities = 347/849 (40%), Positives = 500/849 (58%), Gaps = 77/849 (9%)
Query: 489 SPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEE 548
S ++ LK T + KDSV N +KD Q S ++A + ++ S +N +
Sbjct: 639 SSQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQLAWKATSVKKDSVSN---IAT 695
Query: 549 ERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGP 608
E K + VS+ ++ D + ++ K GE P+K++ +
Sbjct: 696 EIKDGQIRGT-VSSQRQPALKATGDEKDSVSNIAREIKDGEKSGTVSPQKQSAQKVIFKK 754
Query: 609 ALQMKEVKS-------TEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSS------LSE 655
+ + + + + E + ++ + + K S+L D +S L
Sbjct: 755 KVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEM 814
Query: 656 IDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQL 715
E E + ++ N + +VKNQI S DD+DD+ QSS+T SED + + KN +LLI+Q
Sbjct: 815 ASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQH 874
Query: 716 GMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS 775
M+CKD V LLKI+ C+RL ELK NHCE L VKI+K+++K +VLQ+ LSE +EIKS
Sbjct: 875 EMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKS 934
Query: 776 QLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLEL 835
QL+H+ +E E+ELCSLRF++ QE++KRRN + L++K+RE+LR EEQYR E +V + ++
Sbjct: 935 QLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKP 994
Query: 836 SLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK 895
+L K E+E+
Sbjct: 995 AL-----------------------------------------------KSAEVELKTGG 1007
Query: 896 MNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED 955
NS +E++DL H+N ++Q+EIA LRLE DTIKNQN EK K +D +IVK K+ED
Sbjct: 1008 NNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKHED 1065
Query: 956 LQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1015
LQK +K+NEETL +TI+ Y+G+L+ LT EN L SKLE +++S +RLE E++SY RL A
Sbjct: 1066 LQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRLNA 1125
Query: 1016 AIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNS 1075
A+ D DQS +SKR+ ELAFQ D+C LQ+ +N V ILS QL K ESK
Sbjct: 1126 ALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVL-------ILSLQLSKAESKFRV 1178
Query: 1076 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEER 1135
LE E H+T +AL+EK L E VQ +L Q Q QMK++E+ Y++ + K I KQE R
Sbjct: 1179 LETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQE----R 1234
Query: 1136 LSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1195
QL+ +NMLL+QQLDDA NKADN+EK ++NIQ + A V+ LQAE K LLLEE NK
Sbjct: 1235 FCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKM 1294
Query: 1196 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDE 1255
L++E NH KE++ QYE EKAEREV VRQLQQ+ D L K+S ++A L+ +SR+ I LE+
Sbjct: 1295 LVNELNHSKEKKCQYEKEKAEREVAVRQLQQKQDDVLNKRSATKALLDASSRHCIYLENG 1354
Query: 1256 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEEL 1315
QD +KKL Q+R+Q QE QD+ T +RC ++M+ QKLE +N ++ +KKQ ++IE
Sbjct: 1355 MQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERF 1414
Query: 1316 QKNLLNANL 1324
+K L +++L
Sbjct: 1415 EKILQHSSL 1423
Score = 105 bits (262), Expect = 4e-22
Identities = 172/726 (23%), Positives = 302/726 (41%), Gaps = 116/726 (15%)
Query: 477 TRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER 536
TR G + E PE LK TIE K+SV N A MKDVQTS AE DLE+ASE EQ+R
Sbjct: 763 TRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKR 822
Query: 537 -EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQF 595
E ENNQPQV+ + IH DD D +IQ ++ D
Sbjct: 823 LEEYENNQPQVKNQ--------------IH--------SRDDLDDIIQSSQTVSEDGDSL 860
Query: 596 PRKENKEYASSGPALQMKEV-KSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDS--- 651
K V ++ + K+ V+ K L L ++ D+
Sbjct: 861 -------------CCNCKNVILLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQ 907
Query: 652 ---SLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHS--SYK 706
+ ++ +++ +K +EK ++K+Q++ ++ E E C L + K
Sbjct: 908 LRVKIRKL-KNKASVLQKRLSEKEEIKSQLKH--------ETLELEKELCSLRFAIQQEK 958
Query: 707 NFMLLIEQLGMECKDSVSLLKIQ---DAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 763
+E+L + ++ + + + Q +A ++ LK EL T
Sbjct: 959 KKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNN--------- 1009
Query: 764 QRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 823
++SET E K L H+ + E+ LR L ++ K +N + Y K E ++RK E
Sbjct: 1010 SNQVSETDE-KEDLLHENRLMQDEIARLR--LEKDTIKNQNLEKKYLKDFEIVKRKHEDL 1066
Query: 824 RKEVEVKQQ--------LELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQ 875
+K ++ ++ L L E T++S L ++R QR + Q+ R
Sbjct: 1067 QKALKRNEETLAETIACYSGQLAALTDENTTLRSKLE---KQRESGQRLETEMQSYRCRL 1123
Query: 876 DGILTNH---LSKQKEIEMAQKKMNSENSHSHEEEKD----LSHKNSMLQEEIAMLRLEI 928
+ L +H S +++ E+A + + H E LS + S + + +L E+
Sbjct: 1124 NAALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETEL 1183
Query: 929 DTIKNQNQEKE---KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 985
+EK + +LK + + +D++K K T+ + I + R L +N
Sbjct: 1184 HYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQE-RFCQLKKQN 1242
Query: 986 AMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKREL-----------ELAF 1034
+L +L++ + + E + + +R A + + Q+E K L EL
Sbjct: 1243 MLLQQQLDDARNKADNQEKAILNIQARCDARVENL-QAECRKHRLLLEEDNKMLVNELNH 1301
Query: 1035 QRARDECSRLQDKMNFDVS--NLKDNNEILSQQLFKTESKLNS-------LEIEFHHTRD 1085
+ + +C ++K +V+ L+ + + + T++ L++ LE +R
Sbjct: 1302 SKEK-KCQYEKEKAEREVAVRQLQQKQDDVLNKRSATKALLDASSRHCIYLENGMQDSRK 1360
Query: 1086 ALREKTLGLERVQKDLSQTQCQMKEME---QKYQNEQVKVNKYIGKQESVEERLSQLQSE 1142
L + + +Q L+ T KEME QK + E V + K I KQ+ ER ++
Sbjct: 1361 KLDQMRSQFQEIQDQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQH 1420
Query: 1143 NMLLRQ 1148
+ L+ Q
Sbjct: 1421 SSLMLQ 1426
Score = 69.3 bits (168), Expect = 3e-11
Identities = 250/1260 (19%), Positives = 467/1260 (37%), Gaps = 228/1260 (18%)
Query: 483 PVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENN 542
P++ S ++ K T + KDSV N A +K+ Q S
Sbjct: 293 PISGTVSSQKQPAEKATSDEKDSVSNIATEIKEGQQSGTV-------------------- 332
Query: 543 QPQVEEERK---KHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKE 599
PQ + K K + + + ++ I G K S +TD E
Sbjct: 333 SPQKQSAWKVIFKKKVSLLNIATRITGGGKSGTVSSQKQPP--SKATSDKTDSALNIATE 390
Query: 600 NKEYASSGPALQMKE--VKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEID 657
K+ G K+ +K+T E ++SV++ ++ D +
Sbjct: 391 IKDGLQCGTVSSQKQPALKATTDE----EDSVSNIA-----------TEIKDGEKSGTVS 435
Query: 658 EDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGM 717
+ K T++E++ V N + D + SET S + + + + +
Sbjct: 436 SQKQPALKATTDEEDSVLNIATEIKD----GEKSETVSSQKQPALKATTDEEDSVSIIAT 491
Query: 718 ECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETK----EI 773
E KD + +S + LK E + E K + R +S K +
Sbjct: 492 EIKDGE-----KSGTVSSRKKPALKATSDEKDSFSNITREKKDGEISRTVSSQKPPALKA 546
Query: 774 KSQLEHQKVEWERELCSLRFSLNQEEEK-------RRNADTLY-----EKIREQLRRKEE 821
S E + RE S E+ R D+L +K E+ RR
Sbjct: 547 TSDEEDSVLSIAREEKDGEKSRTVSSEQPPGLKATRDEKDSLLNIARGKKYGEKTRRVSS 606
Query: 822 QYRKEVEVKQQLELSLQTLEMELR------TVKSNLNQVVQERNDAQRQLSREQNARMLQ 875
+ ++ E S+ + E + TV S ++ +D + +S ++
Sbjct: 607 HKQPALKATSDKENSVPNMATETKDEQISGTVSSQKQPALKATSDKKDSVSNIPTE--IK 664
Query: 876 DGILTNHLSKQKEIEMAQKKMNSEN-SHSHEEEKDLSHKNSMLQEEIAMLRL---EIDTI 931
DG + +S QK++ + ++ S+ E KD + ++ + L+ E D++
Sbjct: 665 DGQQSGTVSSQKQLAWKATSVKKDSVSNIATEIKDGQIRGTVSSQRQPALKATGDEKDSV 724
Query: 932 KNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSK 991
N +E K E V + + QK I + + +L ++ G T
Sbjct: 725 --SNIAREIKDGEKSGTVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGT--------- 773
Query: 992 LENEKQSKERLEAEVESYHSRL--AAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1049
++ L+A +E+ +S L A + D S ++++LE+A + E RL++ N
Sbjct: 774 --EYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMA---SEGEQKRLEEYEN 828
Query: 1050 FDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1109
N + Q+ H+RD L + + V +D C K
Sbjct: 829 --------NQPQVKNQI---------------HSRDDLDDIIQSSQTVSEDGDSLCCNCK 865
Query: 1110 EMEQKYQNEQVKVNK-----YIGKQESVEERLSQLQSENM-LLRQQLDDAHNKADNKEKT 1163
+ ++K I K + +RL++L+ + LR ++ NKA
Sbjct: 866 NVILLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKA------ 919
Query: 1164 VINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223
+++QK +E E+ L+ EL E L+ + + EK +R V +
Sbjct: 920 ---------SVLQKRLSEKEEIKSQLKHETLELEKELCSLR---FAIQQEKKKRR-NVEE 966
Query: 1224 LQQELADTLK-KQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 1282
L Q++ + L+ + +VT + L+ +LK G NQ+ E D + +
Sbjct: 967 LHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTG-GNNSNQVSET-DEKEDLLH 1024
Query: 1283 CAEKMQDH--KQKLEKDNAKLKVTVKKQMD-------KIEELQKNLLNANLSEDE----- 1328
MQD + +LEKD K + KK + K E+LQK L + E
Sbjct: 1025 ENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNEETLAETIACY 1084
Query: 1329 KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388
QL L + +L L+++ + LE E+ + R +LN H
Sbjct: 1085 SGQLAALTDENTTLRSKLEKQRESGQRLETEMQSY-------RCRLNAALCDHDQSHSSK 1137
Query: 1389 KTSQFEMDIQINKLKHKIDDLTA-------ELETAGSKCLHLDTK----NQILQEELLSM 1437
+ + ++K H ++L + +L A SK L+T+ + L+E+ L
Sbjct: 1138 RDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETELHYTGEALKEKALVF 1197
Query: 1438 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1497
+ VQ + ++ Q K +E+ + + +E+ + +QE +LK+
Sbjct: 1198 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCI----------------EKQERFCQLKKQ 1241
Query: 1498 NLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1557
N+ LQ Q N +E +++++ + R+++L++E K + E+ NK
Sbjct: 1242 NMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNK-------- 1293
Query: 1558 LYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPP---CVGN 1614
+ + EL K + K EV + L +KQ L T+ +++ C+
Sbjct: 1294 MLVNELNHSKEKKCQYEKEKAE-REVAVRQLQQKQDD-VLNKRSATKALLDASSRHCIYL 1351
Query: 1615 LNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNI--TRELKEAAAELE 1672
N D +KL + M + ++Q +L I T+E++ A +LE
Sbjct: 1352 ENGMQDSRKKL-----------------DQMRSQFQEIQDQLTATIRCTKEMEGDAQKLE 1394
>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 868
Score = 561 bits (1447), Expect = e-159
Identities = 343/851 (40%), Positives = 499/851 (58%), Gaps = 81/851 (9%)
Query: 489 SPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEE 548
S ++ LK T + KDSV N +KD Q S V+S+++ + + + V
Sbjct: 77 SSQKQPALKATSDKKDSVSNIPTEIKDGQQSGT------VSSQKQPAWKATSVKKDSVSN 130
Query: 549 ERKKHRNNEME--VSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASS 606
+ ++ ++ VS+ ++ D + ++ K GE P+K++ +
Sbjct: 131 IATEIKDGQIRGTVSSQRQPALKATGDEKDSVSNIAREIKDGEKSGTVSPQKQSAQKVIF 190
Query: 607 GPALQMKEVKS-------TEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSS------L 653
+ + + + + E + ++ + + K S+L D +S L
Sbjct: 191 KKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDL 250
Query: 654 SEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIE 713
E E + ++ N + +VKNQI S DD+DD+ QSS+T SED + + KN +LLI+
Sbjct: 251 EMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLID 310
Query: 714 QLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEI 773
Q M+CKD V LLKI+ C+RL ELK NHCE L VKI+K+++K +VLQ+ LSE +EI
Sbjct: 311 QHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEI 370
Query: 774 KSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL 833
KSQL+H+ +E E+ELCSLRF++ QE++KRRN + L++K+RE+LR EEQYR E +V + +
Sbjct: 371 KSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPI 430
Query: 834 ELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ 893
+ +L K E+E+
Sbjct: 431 KPAL-----------------------------------------------KSAEVELKT 443
Query: 894 KKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKN 953
NS +E++DL H+N ++Q+EIA LRLE DTIKNQN EK K +D +IVK K+
Sbjct: 444 GGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKH 501
Query: 954 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRL 1013
EDLQK +K+NEETL +TI+ Y+G+L+ LT EN L SKLE +++S +RLE E++SY RL
Sbjct: 502 EDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRL 561
Query: 1014 AAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1073
AA+ D DQS +SKR+ ELAFQ D+C LQ+ +N V ILS QL K ESK
Sbjct: 562 NAALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVL-------ILSLQLSKAESKF 614
Query: 1074 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVE 1133
LE E H+T +AL+EK L E VQ +L Q Q QMK++E+ Y++ + K I KQE
Sbjct: 615 RVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQE--- 671
Query: 1134 ERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERN 1193
R QL+ +NMLL+QQLDDA NKADN+EK ++NIQ + A V+ LQAE K LLLEE N
Sbjct: 672 -RFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDN 730
Query: 1194 KELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE 1253
K L++E H KE++ QYE EKAEREV VRQLQQ+ D L K S ++A L+ +SR+ LE
Sbjct: 731 KMLVNELTHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLE 790
Query: 1254 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIE 1313
+ QD +KKL Q+R+Q QE QD+ T +RC ++M+ QKLE +N ++ +KKQ ++IE
Sbjct: 791 NGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIE 850
Query: 1314 ELQKNLLNANL 1324
+K L +++L
Sbjct: 851 RFEKILQHSSL 861
Score = 107 bits (266), Expect = 1e-22
Identities = 173/726 (23%), Positives = 302/726 (41%), Gaps = 116/726 (15%)
Query: 477 TRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER 536
TR G + E PE LK TIE K+SV N A MKDVQTS AE DLE+ASE EQ+R
Sbjct: 201 TRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKR 260
Query: 537 -EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQF 595
E ENNQPQV+ + IH DD D +IQ ++ D
Sbjct: 261 LEEYENNQPQVKNQ--------------IH--------SRDDLDDIIQSSQTVSEDGDSL 298
Query: 596 PRKENKEYASSGPALQMKEV-KSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDS--- 651
K V ++ + K+ V+ K L L ++ D+
Sbjct: 299 -------------CCNCKNVILLIDQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQ 345
Query: 652 ---SLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHS--SYK 706
+ ++ +++ +K +EK ++K+Q++ ++ E E C L + K
Sbjct: 346 LRVKIRKL-KNKASVLQKRLSEKEEIKSQLKH--------ETLELEKELCSLRFAIQQEK 396
Query: 707 NFMLLIEQLGMECKDSVSLLKIQ---DAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 763
+E+L + ++ + + + Q +A ++ LK EL T
Sbjct: 397 KKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNN--------- 447
Query: 764 QRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 823
++SET E K L H+ + E+ LR L ++ K +N + Y K E ++RK E
Sbjct: 448 SNQVSETDE-KEDLLHENRLMQDEIARLR--LEKDTIKNQNLEKKYLKDFEIVKRKHEDL 504
Query: 824 RKEVEVKQQ--------LELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQ 875
+K ++ ++ L L E T++S L ++R QR + Q+ R
Sbjct: 505 QKALKRNEETLAETIACYSGQLAALTDENTTLRSKLE---KQRESGQRLETEMQSYRCRL 561
Query: 876 DGILTNH---LSKQKEIEMAQKKMNSENSHSHEEEKD----LSHKNSMLQEEIAMLRLEI 928
+ L +H S +++ E+A + + H E LS + S + + +L E+
Sbjct: 562 NAALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETEL 621
Query: 929 DTIKNQNQEKE---KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 985
+EK + +LK + + +D++K K T+ + I + R L +N
Sbjct: 622 HYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQE-RFCQLKKQN 680
Query: 986 AMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKREL-----------ELAF 1034
+L +L++ + + E + + +R A + + Q+E K L EL
Sbjct: 681 MLLQQQLDDARNKADNQEKAILNIQARCDARVENL-QAECRKHRLLLEEDNKMLVNELTH 739
Query: 1035 QRARDECSRLQDKMNFDVS--NLKDNNEILSQQLFKTESKLNS-------LEIEFHHTRD 1085
+ + EC ++K +V+ L+ + + + T++ L++ LE +R
Sbjct: 740 SKEK-ECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRK 798
Query: 1086 ALREKTLGLERVQKDLSQTQCQMKEME---QKYQNEQVKVNKYIGKQESVEERLSQLQSE 1142
L + + +Q L+ T KEME QK + E V + K I KQ+ ER ++
Sbjct: 799 KLDQMRSQFQEIQDQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQH 858
Query: 1143 NMLLRQ 1148
+ L+ Q
Sbjct: 859 SSLMLQ 864
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 539 bits (1388), Expect = e-152
Identities = 338/816 (41%), Positives = 493/816 (60%), Gaps = 86/816 (10%)
Query: 838 QTLEMELRTVKSNLNQVVQE----------RNDAQRQLSREQNARMLQDGILTNHLSKQK 887
Q LE + + +K++L QE + +++L + + + + KQ+
Sbjct: 350 QILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQE 409
Query: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 947
+E ++ K ++S S+ ++KD N ML+ +IAML+ E+ IKN + KEKK +++K
Sbjct: 410 RLERSENKQ-PQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIK 468
Query: 948 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
+ E N + +K+++ NEE +T+ ++QY+ +L+ L AENA LNSKLE EK +KERLEAEVE
Sbjct: 469 SITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVE 528
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1067
S HS LA AI++ ++ +++LEL RA D+ SR + M ++S L D NE+L++Q+
Sbjct: 529 SLHSNLATAINEYNEI-LERKDLELVLWRA-DDVSR-HETMGSNISQLTDKNELLTEQVH 585
Query: 1068 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 1127
K K N+L+ + TRDALREKTL LE VQ DL Q Q ++KEM+Q + N + K ++ IG
Sbjct: 586 KARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIG 645
Query: 1128 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
KQ S EER+ Q + EN+LL +QL+DA + DNKE VINI E+ K+
Sbjct: 646 KQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC--------LENGKED- 695
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LLEERNKEL++E N+LKE+ QYE EKAEREV+VR+ Q+EL D LKK SMSE+ LE TS
Sbjct: 696 LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSH 755
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
INL DET KKKL Q+ Q +E + + + ++ K N +L+
Sbjct: 756 CHINL-DETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEA-T 813
Query: 1308 QMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLL 1367
K E+ N+LNA +ED C+ D
Sbjct: 814 GYKKCLEMTINMLNAFANED--------------FSCHGD-------------------- 839
Query: 1368 KMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKN 1427
L T Q +MDI KLK K DDL AE E SKC++L N
Sbjct: 840 --------------------LNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDN 879
Query: 1428 QILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR 1487
++L +ELLSM VQ+KCEKL+K+KK LE++V+NL++H+E++MVELG+V++YK E++ERA
Sbjct: 880 EVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAM 939
Query: 1488 QEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDF 1547
Q I EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+ ED
Sbjct: 940 QAI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAYEDV 995
Query: 1548 NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVM 1607
TELE+YK+ + LK S+S K+TK+++++A ++TKL +EK++ +TL RP
Sbjct: 996 T-TELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDP 1054
Query: 1608 EPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNN 1643
E PCV NL NS++LNRK IP+ + I TSNP+ SNN
Sbjct: 1055 ELPCVENL-NSIELNRKYIPKMAIRIPTSNPQTSNN 1089
Score = 219 bits (557), Expect = 2e-56
Identities = 105/185 (56%), Positives = 141/185 (76%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ GYH+RD +L KIH+AA G+ A+V+ L R L+ RDK +RT LHLACA+G +
Sbjct: 122 YAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQ 181
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+DRKCQ+N+CD NRT LMKAV CQEE CA ILL+ GA+PN+ D++GNTALHYAV
Sbjct: 182 VVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAV 241
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YNE S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 242 YNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 301
Query: 215 HQLIS 219
+++
Sbjct: 302 ALILA 306
Score = 68.9 bits (167), Expect = 4e-11
Identities = 135/654 (20%), Positives = 264/654 (40%), Gaps = 96/654 (14%)
Query: 513 MKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDD 571
+K + AEH+L+VASEE+QER E SEN QPQ + K +
Sbjct: 387 LKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKK----------------- 429
Query: 572 AEDDDDDDGLIQKRKSGETDHQQFP------RKENKEYASSGPALQMKEVKSTEKEKRTS 625
D+ + KR + + RKE K ++E+KS +
Sbjct: 430 ---DEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK---------YIQEIKSITEINANF 477
Query: 626 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 685
++SV ++T + Q L+++ + R K EK+ K ++++ +V+
Sbjct: 478 EKSVRL----NEEMITKKVAQYSQQ--LNDLKAENARLNSKLEKEKHN-KERLEA--EVE 528
Query: 686 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLEL 741
L + TA + + ++E+ +E D VS + + +S +L +
Sbjct: 529 SLHSNLATAINE----------YNEILERKDLELVLWRADDVSRHETMGSNIS--QLTD- 575
Query: 742 KKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
KN ELLT ++ K K N L+ +L ET++ + + +L + + + ++
Sbjct: 576 -KN--ELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQM 632
Query: 802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDA 861
N + + + EE+ R+ LE L+ E + +N +
Sbjct: 633 HPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENG 692
Query: 862 QRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEI 921
+ L E+N ++ + N+L K+K ++ ++K E +E+ + H E
Sbjct: 693 KEDLLEERNKELMNE---YNYL-KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSES 748
Query: 922 AMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 980
+ I ++ +KK F+ +EK+E+ +K + IS N
Sbjct: 749 PLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVF--------ELISLLNYTADQ 800
Query: 981 LTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRAR-- 1038
+ +N L E K+ LE + ++ T + ++++ F++ +
Sbjct: 801 IRKKNRELE---EEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQK 857
Query: 1039 -DECSRLQDKMNFDVSNLKDNNEILSQQLF---KTESKLNSLEIEFHHTRDALREKTLGL 1094
D+ ++ ++ NL +NE+L Q+L K + K LE + + L EK L L
Sbjct: 858 FDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKD----KKMLEEKVLNL 913
Query: 1095 ----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSEN 1143
E+ +L + Q E++++ K+ + ++ KQ E++L QL +N
Sbjct: 914 KTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 967
Score = 49.3 bits (116), Expect = 3e-05
Identities = 101/502 (20%), Positives = 198/502 (39%), Gaps = 91/502 (18%)
Query: 1221 VRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
+R +QQ++ + K M + L ++ ++ E +KK +++ + + A+ H
Sbjct: 344 LRSIQQQILE--HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLK 401
Query: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIE---------ELQKNLLNANLSEDEKEQ 1331
V EK Q+ ++ E + + K+ D++ + K L A ++ +++
Sbjct: 402 VASEEK-QERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKE 460
Query: 1332 LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTS 1391
K + E+K E N + E K+V L E M KK+ +Y DLK
Sbjct: 461 KKYIQEIKSITEINANFE--KSVRLNEE---------MITKKVAQYSQQL----NDLKAE 505
Query: 1392 QFEMDIQINKLKHKIDDLTAELETAGSK-CLHLDTKNQILQ----EELLSMKTVQKKCEK 1446
++ ++ K KH + L AE+E+ S ++ N+IL+ E +L + E
Sbjct: 506 NARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHET 565
Query: 1447 LQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAA 1506
+ N +L + L + + V+ +K +E + R++ L+ V L L+
Sbjct: 566 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA-LESVQLDLKQAQH 624
Query: 1507 SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR 1566
+ ++Q N A ES+ + S E E+ +Q LE L +
Sbjct: 625 RIKEMKQMHPNGEAK------------ESQSIGKQNSSE-------ERIRQRELENLLLE 665
Query: 1567 KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSL--DLNRK 1624
+ L + + + +N + C+ N L + N++
Sbjct: 666 RQLEDARKEGDNKEIVIN----------------------IHRDCLENGKEDLLEERNKE 703
Query: 1625 LIPRENLVISTSNPRASNNSMENYLSKMQQELEKN-ITRELKEAAAE-LESGSIA-SPLG 1681
L+ N + E L +++ E+ I RE +E + L+ S++ SPL
Sbjct: 704 LMNEYNYL------------KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLE 751
Query: 1682 STDESNLNQDLVWKASREYVQV 1703
T ++N D W + ++ QV
Sbjct: 752 GTSHCHINLDETWTSKKKLFQV 773
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 539 bits (1388), Expect = e-152
Identities = 338/816 (41%), Positives = 493/816 (60%), Gaps = 86/816 (10%)
Query: 838 QTLEMELRTVKSNLNQVVQE----------RNDAQRQLSREQNARMLQDGILTNHLSKQK 887
Q LE + + +K++L QE + +++L + + + + KQ+
Sbjct: 379 QILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQE 438
Query: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 947
+E ++ K ++S S+ ++KD N ML+ +IAML+ E+ IKN + KEKK +++K
Sbjct: 439 RLERSENKQ-PQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIK 497
Query: 948 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
+ E N + +K+++ NEE +T+ ++QY+ +L+ L AENA LNSKLE EK +KERLEAEVE
Sbjct: 498 SITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVE 557
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1067
S HS LA AI++ ++ +++LEL RA D+ SR + M ++S L D NE+L++Q+
Sbjct: 558 SLHSNLATAINEYNEI-LERKDLELVLWRA-DDVSR-HETMGSNISQLTDKNELLTEQVH 614
Query: 1068 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 1127
K K N+L+ + TRDALREKTL LE VQ DL Q Q ++KEM+Q + N + K ++ IG
Sbjct: 615 KARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIG 674
Query: 1128 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
KQ S EER+ Q + EN+LL +QL+DA + DNKE VINI E+ K+
Sbjct: 675 KQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC--------LENGKED- 724
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LLEERNKEL++E N+LKE+ QYE EKAEREV+VR+ Q+EL D LKK SMSE+ LE TS
Sbjct: 725 LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSH 784
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
INL DET KKKL Q+ Q +E + + + ++ K N +L+
Sbjct: 785 CHINL-DETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEA-T 842
Query: 1308 QMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLL 1367
K E+ N+LNA +ED C+ D
Sbjct: 843 GYKKCLEMTINMLNAFANED--------------FSCHGD-------------------- 868
Query: 1368 KMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKN 1427
L T Q +MDI KLK K DDL AE E SKC++L N
Sbjct: 869 --------------------LNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDN 908
Query: 1428 QILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR 1487
++L +ELLSM VQ+KCEKL+K+KK LE++V+NL++H+E++MVELG+V++YK E++ERA
Sbjct: 909 EVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAM 968
Query: 1488 QEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDF 1547
Q I EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+ ED
Sbjct: 969 QAI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAYEDV 1024
Query: 1548 NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVM 1607
TELE+YK+ + LK S+S K+TK+++++A ++TKL +EK++ +TL RP
Sbjct: 1025 T-TELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDP 1083
Query: 1608 EPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNN 1643
E PCV NL NS++LNRK IP+ + I TSNP+ SNN
Sbjct: 1084 ELPCVENL-NSIELNRKYIPKMAIRIPTSNPQTSNN 1118
Score = 219 bits (557), Expect = 2e-56
Identities = 105/185 (56%), Positives = 141/185 (76%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ GYH+RD +L KIH+AA G+ A+V+ L R L+ RDK +RT LHLACA+G +
Sbjct: 151 YAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQ 210
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+DRKCQ+N+CD NRT LMKAV CQEE CA ILL+ GA+PN+ D++GNTALHYAV
Sbjct: 211 VVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAV 270
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YNE S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 271 YNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 330
Query: 215 HQLIS 219
+++
Sbjct: 331 ALILA 335
Score = 68.9 bits (167), Expect = 4e-11
Identities = 135/654 (20%), Positives = 264/654 (40%), Gaps = 96/654 (14%)
Query: 513 MKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDD 571
+K + AEH+L+VASEE+QER E SEN QPQ + K +
Sbjct: 416 LKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKK----------------- 458
Query: 572 AEDDDDDDGLIQKRKSGETDHQQFP------RKENKEYASSGPALQMKEVKSTEKEKRTS 625
D+ + KR + + RKE K ++E+KS +
Sbjct: 459 ---DEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK---------YIQEIKSITEINANF 506
Query: 626 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 685
++SV ++T + Q L+++ + R K EK+ K ++++ +V+
Sbjct: 507 EKSVRL----NEEMITKKVAQYSQQ--LNDLKAENARLNSKLEKEKHN-KERLEA--EVE 557
Query: 686 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLEL 741
L + TA + + ++E+ +E D VS + + +S +L +
Sbjct: 558 SLHSNLATAINE----------YNEILERKDLELVLWRADDVSRHETMGSNIS--QLTD- 604
Query: 742 KKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
KN ELLT ++ K K N L+ +L ET++ + + +L + + + ++
Sbjct: 605 -KN--ELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQM 661
Query: 802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDA 861
N + + + EE+ R+ LE L+ E + +N +
Sbjct: 662 HPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENG 721
Query: 862 QRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEI 921
+ L E+N ++ + N+L K+K ++ ++K E +E+ + H E
Sbjct: 722 KEDLLEERNKELMNE---YNYL-KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSES 777
Query: 922 AMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 980
+ I ++ +KK F+ +EK+E+ +K + IS N
Sbjct: 778 PLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVF--------ELISLLNYTADQ 829
Query: 981 LTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRAR-- 1038
+ +N L E K+ LE + ++ T + ++++ F++ +
Sbjct: 830 IRKKNRELE---EEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQK 886
Query: 1039 -DECSRLQDKMNFDVSNLKDNNEILSQQLF---KTESKLNSLEIEFHHTRDALREKTLGL 1094
D+ ++ ++ NL +NE+L Q+L K + K LE + + L EK L L
Sbjct: 887 FDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKD----KKMLEEKVLNL 942
Query: 1095 ----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSEN 1143
E+ +L + Q E++++ K+ + ++ KQ E++L QL +N
Sbjct: 943 KTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 996
Score = 49.3 bits (116), Expect = 3e-05
Identities = 101/502 (20%), Positives = 198/502 (39%), Gaps = 91/502 (18%)
Query: 1221 VRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
+R +QQ++ + K M + L ++ ++ E +KK +++ + + A+ H
Sbjct: 373 LRSIQQQILE--HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLK 430
Query: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIE---------ELQKNLLNANLSEDEKEQ 1331
V EK Q+ ++ E + + K+ D++ + K L A ++ +++
Sbjct: 431 VASEEK-QERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKE 489
Query: 1332 LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTS 1391
K + E+K E N + E K+V L E M KK+ +Y DLK
Sbjct: 490 KKYIQEIKSITEINANFE--KSVRLNEE---------MITKKVAQYSQQL----NDLKAE 534
Query: 1392 QFEMDIQINKLKHKIDDLTAELETAGSK-CLHLDTKNQILQ----EELLSMKTVQKKCEK 1446
++ ++ K KH + L AE+E+ S ++ N+IL+ E +L + E
Sbjct: 535 NARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHET 594
Query: 1447 LQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAA 1506
+ N +L + L + + V+ +K +E + R++ L+ V L L+
Sbjct: 595 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA-LESVQLDLKQAQH 653
Query: 1507 SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR 1566
+ ++Q N A ES+ + S E E+ +Q LE L +
Sbjct: 654 RIKEMKQMHPNGEAK------------ESQSIGKQNSSE-------ERIRQRELENLLLE 694
Query: 1567 KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSL--DLNRK 1624
+ L + + + +N + C+ N L + N++
Sbjct: 695 RQLEDARKEGDNKEIVIN----------------------IHRDCLENGKEDLLEERNKE 732
Query: 1625 LIPRENLVISTSNPRASNNSMENYLSKMQQELEKN-ITRELKEAAAE-LESGSIA-SPLG 1681
L+ N + E L +++ E+ I RE +E + L+ S++ SPL
Sbjct: 733 LMNEYNYL------------KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLE 780
Query: 1682 STDESNLNQDLVWKASREYVQV 1703
T ++N D W + ++ QV
Sbjct: 781 GTSHCHINLDETWTSKKKLFQV 802
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 539 bits (1388), Expect = e-152
Identities = 338/816 (41%), Positives = 493/816 (60%), Gaps = 86/816 (10%)
Query: 838 QTLEMELRTVKSNLNQVVQE----------RNDAQRQLSREQNARMLQDGILTNHLSKQK 887
Q LE + + +K++L QE + +++L + + + + KQ+
Sbjct: 379 QILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQE 438
Query: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 947
+E ++ K ++S S+ ++KD N ML+ +IAML+ E+ IKN + KEKK +++K
Sbjct: 439 RLERSENKQ-PQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIK 497
Query: 948 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
+ E N + +K+++ NEE +T+ ++QY+ +L+ L AENA LNSKLE EK +KERLEAEVE
Sbjct: 498 SITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVE 557
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1067
S HS LA AI++ ++ +++LEL RA D+ SR + M ++S L D NE+L++Q+
Sbjct: 558 SLHSNLATAINEYNEI-LERKDLELVLWRA-DDVSR-HETMGSNISQLTDKNELLTEQVH 614
Query: 1068 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 1127
K K N+L+ + TRDALREKTL LE VQ DL Q Q ++KEM+Q + N + K ++ IG
Sbjct: 615 KARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIG 674
Query: 1128 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
KQ S EER+ Q + EN+LL +QL+DA + DNKE VINI E+ K+
Sbjct: 675 KQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC--------LENGKED- 724
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LLEERNKEL++E N+LKE+ QYE EKAEREV+VR+ Q+EL D LKK SMSE+ LE TS
Sbjct: 725 LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSH 784
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
INL DET KKKL Q+ Q +E + + + ++ K N +L+
Sbjct: 785 CHINL-DETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEA-T 842
Query: 1308 QMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLL 1367
K E+ N+LNA +ED C+ D
Sbjct: 843 GYKKCLEMTINMLNAFANED--------------FSCHGD-------------------- 868
Query: 1368 KMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKN 1427
L T Q +MDI KLK K DDL AE E SKC++L N
Sbjct: 869 --------------------LNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDN 908
Query: 1428 QILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR 1487
++L +ELLSM VQ+KCEKL+K+KK LE++V+NL++H+E++MVELG+V++YK E++ERA
Sbjct: 909 EVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAM 968
Query: 1488 QEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDF 1547
Q I EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+ ED
Sbjct: 969 QAI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAYEDV 1024
Query: 1548 NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVM 1607
TELE+YK+ + LK S+S K+TK+++++A ++TKL +EK++ +TL RP
Sbjct: 1025 T-TELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDP 1083
Query: 1608 EPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNN 1643
E PCV NL NS++LNRK IP+ + I TSNP+ SNN
Sbjct: 1084 ELPCVENL-NSIELNRKYIPKMAIRIPTSNPQTSNN 1118
Score = 218 bits (554), Expect = 5e-56
Identities = 104/185 (56%), Positives = 141/185 (76%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ GYH+RD +L KIH+AA G+ A+V+ L R L+ RD+ +RT LHLACA+G +
Sbjct: 151 YAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQ 210
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+DRKCQ+N+CD NRT LMKAV CQEE CA ILL+ GA+PN+ D++GNTALHYAV
Sbjct: 211 VVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAV 270
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YNE S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 271 YNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 330
Query: 215 HQLIS 219
+++
Sbjct: 331 ALILA 335
Score = 68.9 bits (167), Expect = 4e-11
Identities = 135/654 (20%), Positives = 264/654 (40%), Gaps = 96/654 (14%)
Query: 513 MKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDD 571
+K + AEH+L+VASEE+QER E SEN QPQ + K +
Sbjct: 416 LKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKK----------------- 458
Query: 572 AEDDDDDDGLIQKRKSGETDHQQFP------RKENKEYASSGPALQMKEVKSTEKEKRTS 625
D+ + KR + + RKE K ++E+KS +
Sbjct: 459 ---DEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK---------YIQEIKSITEINANF 506
Query: 626 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 685
++SV ++T + Q L+++ + R K EK+ K ++++ +V+
Sbjct: 507 EKSVRL----NEEMITKKVAQYSQQ--LNDLKAENARLNSKLEKEKHN-KERLEA--EVE 557
Query: 686 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLEL 741
L + TA + + ++E+ +E D VS + + +S +L +
Sbjct: 558 SLHSNLATAINE----------YNEILERKDLELVLWRADDVSRHETMGSNIS--QLTD- 604
Query: 742 KKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
KN ELLT ++ K K N L+ +L ET++ + + +L + + + ++
Sbjct: 605 -KN--ELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQM 661
Query: 802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDA 861
N + + + EE+ R+ LE L+ E + +N +
Sbjct: 662 HPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENG 721
Query: 862 QRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEI 921
+ L E+N ++ + N+L K+K ++ ++K E +E+ + H E
Sbjct: 722 KEDLLEERNKELMNE---YNYL-KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSES 777
Query: 922 AMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 980
+ I ++ +KK F+ +EK+E+ +K + IS N
Sbjct: 778 PLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVF--------ELISLLNYTADQ 829
Query: 981 LTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRAR-- 1038
+ +N L E K+ LE + ++ T + ++++ F++ +
Sbjct: 830 IRKKNRELE---EEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQK 886
Query: 1039 -DECSRLQDKMNFDVSNLKDNNEILSQQLF---KTESKLNSLEIEFHHTRDALREKTLGL 1094
D+ ++ ++ NL +NE+L Q+L K + K LE + + L EK L L
Sbjct: 887 FDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKD----KKMLEEKVLNL 942
Query: 1095 ----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSEN 1143
E+ +L + Q E++++ K+ + ++ KQ E++L QL +N
Sbjct: 943 KTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 996
Score = 49.3 bits (116), Expect = 3e-05
Identities = 101/502 (20%), Positives = 198/502 (39%), Gaps = 91/502 (18%)
Query: 1221 VRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
+R +QQ++ + K M + L ++ ++ E +KK +++ + + A+ H
Sbjct: 373 LRSIQQQILE--HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLK 430
Query: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIE---------ELQKNLLNANLSEDEKEQ 1331
V EK Q+ ++ E + + K+ D++ + K L A ++ +++
Sbjct: 431 VASEEK-QERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKE 489
Query: 1332 LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTS 1391
K + E+K E N + E K+V L E M KK+ +Y DLK
Sbjct: 490 KKYIQEIKSITEINANFE--KSVRLNEE---------MITKKVAQYSQQL----NDLKAE 534
Query: 1392 QFEMDIQINKLKHKIDDLTAELETAGSK-CLHLDTKNQILQ----EELLSMKTVQKKCEK 1446
++ ++ K KH + L AE+E+ S ++ N+IL+ E +L + E
Sbjct: 535 NARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHET 594
Query: 1447 LQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAA 1506
+ N +L + L + + V+ +K +E + R++ L+ V L L+
Sbjct: 595 MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA-LESVQLDLKQAQH 653
Query: 1507 SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR 1566
+ ++Q N A ES+ + S E E+ +Q LE L +
Sbjct: 654 RIKEMKQMHPNGEAK------------ESQSIGKQNSSE-------ERIRQRELENLLLE 694
Query: 1567 KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSL--DLNRK 1624
+ L + + + +N + C+ N L + N++
Sbjct: 695 RQLEDARKEGDNKEIVIN----------------------IHRDCLENGKEDLLEERNKE 732
Query: 1625 LIPRENLVISTSNPRASNNSMENYLSKMQQELEKN-ITRELKEAAAE-LESGSIA-SPLG 1681
L+ N + E L +++ E+ I RE +E + L+ S++ SPL
Sbjct: 733 LMNEYNYL------------KEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLE 780
Query: 1682 STDESNLNQDLVWKASREYVQV 1703
T ++N D W + ++ QV
Sbjct: 781 GTSHCHINLDETWTSKKKLFQV 802
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 499 bits (1284), Expect = e-140
Identities = 384/1078 (35%), Positives = 556/1078 (51%), Gaps = 134/1078 (12%)
Query: 173 EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQ 232
E K T + V+ K +++E K ++ + A ESS + + ++R P S Q
Sbjct: 364 EKKETPVKTGCVARVTSNKTKVLE---KGRSKMIACPTKESSTK--ASANDQRFPSESKQ 418
Query: 233 NSNSVDESSEDSLSRLSGKPGVDDSWPTSDDE---DLNFDTKNVPK-PSLAKLMTASQQS 288
+ +E S DS S + P S + ++N + + PK PS K Q S
Sbjct: 419 EED--EEYSCDSRSLFESSAKIQVCIPESIYQKVMEINREVEEPPKKPSAFKPAIEMQNS 476
Query: 289 RKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPS 348
N +T +S +D S + Q LPK +
Sbjct: 477 VPNKAFELKNEQTLRADPMFPPESKQKD------YEENSWDSESLCETVSQKDVCLPKAT 530
Query: 349 HKSLANP--GLMKEEPTKPGIAKKENGIDI-------------------------IESAP 381
H+ + G ++E P K G+ K G+ + E A
Sbjct: 531 HQKEIDKINGKLEESPNKDGLLKATCGMKVSIPTKALELKDMQTFKAEPPGKPSAFEPAT 590
Query: 382 LEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAA 441
Q + N + + R+D + Q++ E+ WD+ES+ E QK V L AA
Sbjct: 591 EMQKSVPNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVC-LPKAA 649
Query: 442 DGKEKNIGNEQAEDVFYIPSCMSGSRNFKMA-KLEDTRNVGMPVAHMESPERYLHLKPTI 500
KE + N + E + + K++ + + M E PE+ +P I
Sbjct: 650 HQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAI 709
Query: 501 EMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEV 560
EM+ SVPNKA +K+ QT +A E L S+++ E S +++ E +K
Sbjct: 710 EMQKSVPNKALELKNEQTLRADEI-LPSESKQKDYEESSWDSESLCETVSQKDVCLPKAT 768
Query: 561 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEK 620
D E+ D+DG + K+ P K AL++ +++ T K
Sbjct: 769 HQKEIDKINGKLEESPDNDGFL---KAPCRMKVSIPTK----------ALELMDMQ-TFK 814
Query: 621 EKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQS 680
+ K S P + L++ ++ +L D+ P++ +K K ++
Sbjct: 815 AEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRA---DQMFPSE------SKQKKVEEN 865
Query: 681 MDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLE 740
D + L ++ + +D +P ++++ M +++ + +DS SL KI D SCER E
Sbjct: 866 SWDSESLRET--VSQKDVCVPKATHQKEM---DKISGKLEDSTSLSKILDTVHSCERARE 920
Query: 741 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEE 800
L+K+HCE T K+++M+ K VL+++LSE KEIKSQLE+QKV+WE+ELCS+R +LNQEEE
Sbjct: 921 LQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEE 980
Query: 801 KRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERND 860
KRRNAD L EKIRE+L R EEQ+RKE+EVKQQLE +L+ ++EL++V+SNLNQV
Sbjct: 981 KRRNADILNEKIREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQV------ 1034
Query: 861 AQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE 920
SH+HE E L H+N ML++E
Sbjct: 1035 ----------------------------------------SHTHENENYLLHENCMLKKE 1054
Query: 921 IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 980
IAML+LEI T+K+Q QEKE K FED+KI+KEKN +LQ T+K EE+LT+ SQY+G+L V
Sbjct: 1055 IAMLKLEIATLKHQYQEKENKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQLKV 1114
Query: 981 LTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDE 1040
L AEN ML SKL+ EKQ KE LEAE+ES+H RLA+A+ D DQ TS++ E AF A D
Sbjct: 1115 LIAENTMLTSKLK-EKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIAGDA 1173
Query: 1041 CSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKD 1100
C LQ KMN DVS+ NNE+L Q L + + K SL+I ++ DALRE TL E Q+D
Sbjct: 1174 C--LQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQRD 1231
Query: 1101 LSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1160
+TQCQMKE E YQNEQ VNK+ +QES++++L QLQS+NM L+QQL AH KADNK
Sbjct: 1232 QRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKADNK 1291
Query: 1161 EKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERE 1218
K I+I H + +K+Q LL+E+N+E+ + NHLK R YQYE EKAE E
Sbjct: 1292 SKITIDI----HFLERKMQHH------LLKEKNEEIFNYNNHLKNRIYQYEKEKAETE 1339
Score = 216 bits (550), Expect = 2e-55
Identities = 312/1437 (21%), Positives = 579/1437 (40%), Gaps = 236/1437 (16%)
Query: 73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATIL 132
LN +D RTALH AC NGH EVVT LVDRKCQL+V D E+RT LMKA+QC +E CA IL
Sbjct: 10 LNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANIL 69
Query: 133 LEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLL------- 185
++ GAD NL DV+GNTALHYAVY+E +SV KLL + A IE NK LTPLLL
Sbjct: 70 IDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSE 129
Query: 186 --------------------------AVSGKKQQMVEFLIKKKANVNAVD---------- 209
AV ++V L+++ +V A D
Sbjct: 130 QIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYA 189
Query: 210 ---KLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGK-PGVDDSWPTSDDED 265
H+ I EY + H + N + D + L+ + P +S ++
Sbjct: 190 VTCGFHHIHEQIMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDE 249
Query: 266 LNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTL---FEDRDSDSQDEVVVES 322
+ P + + + ++ +E T ++ + FE ++ E+ +
Sbjct: 250 AAPLVERTPDTAESLVEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREITSPA 309
Query: 323 LPTTSIKVQCFSHPTYQSPDLLP----KPSHKSLANPG---------LMKEEPTKPGIAK 369
T+ + F+ P P + + + + + +P K P K K
Sbjct: 310 KETS----EKFTWPAKGRPRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEK 365
Query: 370 KENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENF 429
KE + T+N +V + RS M++ ES + + + F
Sbjct: 366 KETPVKT--GCVARVTSNKT-----KVLEKGRSKMIAC------PTKESSTKASANDQRF 412
Query: 430 PQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDT--RNVGMPVAHM 487
P + ++Q ED Y SC S S AK++ ++ V +
Sbjct: 413 PSE-----------------SKQEEDEEY--SCDSRSLFESSAKIQVCIPESIYQKVMEI 453
Query: 488 -----ESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENN 542
E P++ KP IEM++SVPNKA +K+ QT +A + S+++ E S ++
Sbjct: 454 NREVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQTLRA-DPMFPPESKQKDYEENSWDS 512
Query: 543 QPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKE 602
+ E +K D E+ + DGL++ + P K
Sbjct: 513 ESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKATCGMKVS---IPTK---- 565
Query: 603 YASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGR 662
AL++K+++ T K + K S P + L++ ++ +L DE
Sbjct: 566 ------ALELKDMQ-TFKAEPPGKPSAFEPATEMQKSVPNKALELKNEQTLRA---DEIL 615
Query: 663 PTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFM------------- 709
P++ +K K+ ++ D + L ++ + +D LP ++++ +
Sbjct: 616 PSE------SKQKDYEENSWDTESLCET--VSQKDVCLPKAAHQKEIDKINGKLEGSPVK 667
Query: 710 --LLIEQLGMECKDSVSLLKIQDAAL----------SCERLLELKKNHCELLTVKIKKME 757
LL GM+ L++ D + E +E++K+ V K +E
Sbjct: 668 DGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKS------VPNKALE 721
Query: 758 DKVNVLQRELSETKEIKSQLEHQKVEWERE-LCS--------LRFSLNQEEEKRRNADTL 808
K R Q ++++ W+ E LC L + +Q+E + N
Sbjct: 722 LKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLE 781
Query: 809 YEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSRE 868
+ + + + + K + +QT + E S ++ + +
Sbjct: 782 ESPDNDGFLKAPCRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALEL 841
Query: 869 QNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML--RL 926
+N + L+ + SKQK++E + +SE+ +KD+ + Q+E+ + +L
Sbjct: 842 KNEQTLRADQMFPSESKQKKVE--ENSWDSESLRETVSQKDVCVPKATHQKEMDKISGKL 899
Query: 927 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENA 986
E T ++ + C E+ +LQK Q G++ + +
Sbjct: 900 EDSTSLSKILDTVHSC--------ERARELQK----------DHCEQRTGKMEQMKKKFC 941
Query: 987 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1046
+L KL K+ K +LE + + L + +Q E +R ++ ++ R+E R+++
Sbjct: 942 VLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEE 1001
Query: 1047 KMNFDVS---NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQ 1103
+ ++ L+ I +L ES LN + + L E + ++K+++
Sbjct: 1002 QHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCM----LKKEIAM 1057
Query: 1104 TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1163
+ ++ ++ +YQ ++ NKY + ++E+ ++LQ L + L ++ + K
Sbjct: 1058 LKLEIATLKHQYQEKE---NKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQLKV 1114
Query: 1164 VINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHLKERQYQYENEKAEREV-- 1219
+I + KL+ + +K+ L +E + L S + ++++ +
Sbjct: 1115 LIAENTM---LTSKLKEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIAG 1171
Query: 1220 ---VVRQLQQELADTLKK-----QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQ 1271
+ R++ +++ T+ Q +SEA + S +INL L++ +
Sbjct: 1172 DACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKS-LKINLNYAGDALREN-----TLVS 1225
Query: 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD--------KIEELQKNLLNAN 1323
E R +C K +H + E+DN ++ +D K LQ+ L++A+
Sbjct: 1226 EHAQRDQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAH 1285
Query: 1324 LSEDEKEQLK-KLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1379
D K ++ + L++ ++ +L +E KN E+ KN + K+ E EN
Sbjct: 1286 KKADNKSKITIDIHFLERKMQHHLLKE--KNEEIFNYNNHLKNRIYQYEKEKAETEN 1340
Score = 52.0 bits (123), Expect = 5e-06
Identities = 137/663 (20%), Positives = 259/663 (39%), Gaps = 88/663 (13%)
Query: 954 EDLQKTIKQNE---ETLTQTISQYNGRLSVLTAENAM--LNSKLENEKQSKERLEAEVES 1008
E QK ++N E+L +T+SQ + L T + + +N KLE L+A
Sbjct: 499 ESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKATCGM 558
Query: 1009 YHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFK 1068
S A+ +D +T K E A + + +Q + LK+ + + ++
Sbjct: 559 KVSIPTKALELKDM-QTFKAEPP-GKPSAFEPATEMQKSVPNKALELKNEQTLRADEILP 616
Query: 1069 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQ-CQMKEMEQKYQNEQVKVNKYIG 1127
+ESK E E + E + + +SQ C K QK +++K G
Sbjct: 617 SESKQKDYE-----------ENSWDTESLCETVSQKDVCLPKAAHQK------EIDKING 659
Query: 1128 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
K E + D KA+ K I + +Q +AE ++
Sbjct: 660 KLEG----------------SPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPS 703
Query: 1188 LLE---ERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV 1244
E E K + ++ LK Q +E E + ++ D SE+ E
Sbjct: 704 AFEPAIEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEESSWD-------SESLCET 756
Query: 1245 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA-VRCAEKMQDHKQKLE-KDNAKLK 1302
S+ + L T +K++ +I +L+E+ D C K+ + LE D K
Sbjct: 757 VSQKDVCLPKATH--QKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTFK 814
Query: 1303 VTVKKQMDKIE---ELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE 1359
++ E E+QK++ N L ++ L+ + +E + E RE
Sbjct: 815 AEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRE 874
Query: 1360 ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSK 1419
K++ K ++ E + S + TS ++ ++ + + E K
Sbjct: 875 TVSQKDVC--VPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGK 932
Query: 1420 CLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI-------------- 1465
+ K +L+++L K ++ + L+ K K EQE+ ++R +
Sbjct: 933 MEQMKKKFCVLKKKLSEAKEIKSQ---LENQKVKWEQELCSVRLTLNQEEEKRRNADILN 989
Query: 1466 ERNMVELGQVK-QYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKS 1524
E+ ELG+++ Q+++E+E + + E A +++++ L +Q + EN
Sbjct: 990 EKIREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENC 1049
Query: 1525 QMELRIKDLESELSKIKTS-QEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV 1583
++ I L+ E++ +K QE NK Y E++K+ K +++L T + E
Sbjct: 1050 MLKKEIAMLKLEIATLKHQYQEKENK---------YFEDIKILKEKNAELQMTLKLKEES 1100
Query: 1584 NTK 1586
TK
Sbjct: 1101 LTK 1103
Score = 50.1 bits (118), Expect = 2e-05
Identities = 137/797 (17%), Positives = 317/797 (39%), Gaps = 87/797 (10%)
Query: 797 QEEEKRRNADT--LYEKIRE-QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQ 853
QEE++ + D+ L+E + Q+ E Y+K +E+ +++E E S
Sbjct: 418 QEEDEEYSCDSRSLFESSAKIQVCIPESIYQKVMEINREVE--------EPPKKPSAFKP 469
Query: 854 VVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHK 913
++ +N + +N + L+ + SKQK+ E + +SE+ +KD+
Sbjct: 470 AIEMQNSVPNKAFELKNEQTLRADPMFPPESKQKDYE--ENSWDSESLCETVSQKDVCLP 527
Query: 914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 973
+ Q+EI + +++ N++ + C + I + E +K + + +
Sbjct: 528 KATHQKEIDKINGKLEESPNKDGLLKATCGMKVSIPTKALE-----LKDMQTFKAEPPGK 582
Query: 974 YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELA 1033
+ + ++ N LE + + R + + S E+ +++ E
Sbjct: 583 PSAFEPATEMQKSVPNKALELKNEQTLRADEILPS---------------ESKQKDYEEN 627
Query: 1034 FQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLG 1093
C + K DV K ++ K K+N ++E +D L + G
Sbjct: 628 SWDTESLCETVSQK---DVCLPKAAHQ-------KEIDKING-KLEGSPVKDGLLKANCG 676
Query: 1094 LERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1153
++ + M+ + + + I Q+SV + +L++E L ++ +
Sbjct: 677 MKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEILPS 736
Query: 1154 HNKADNKEKTVINIQDQFHAIVQK----LQAESEKQSLLLEERNKELISECNHLKERQYQ 1209
+K + E++ + + + QK +A +K+ + + +E LK +
Sbjct: 737 ESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGFLKA-PCR 795
Query: 1210 YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ 1269
+ + + + +Q A+ +K S E ++E+ ++ ++ +LK + +Q
Sbjct: 796 MKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQK----SVPNKALELKNEQTLRADQ 851
Query: 1270 LQEAQDRHTEAVRCAEKMQDHKQKL-EKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1328
+ ++ + + + + ++ + +KD K T +K+MDKI ++ + + D
Sbjct: 852 MFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDT 911
Query: 1329 KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388
++ EL++ + +Q K +++++ K L ++ ++ EN + + +L
Sbjct: 912 VHSCERARELQKD---HCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQEL 968
Query: 1389 KTSQFEMDIQINK------LKHKIDDLTAELETAGSKCLHLDTKNQILQE------ELLS 1436
+ + ++ + K L KI + +E K L+ K Q+ Q EL S
Sbjct: 969 CSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRK--ELEVKQQLEQALRIQDIELKS 1026
Query: 1437 MKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEER----------- 1485
+++ + +N+ L E L+ I +E+ +K QE E +
Sbjct: 1027 VESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEK 1086
Query: 1486 -ARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASM----KSQMELRIKDLESELSKI 1540
A ++ KLKE +L +A S + EN + K E+ ++ES ++
Sbjct: 1087 NAELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLKEKQDKEILEAEIESHHPRL 1146
Query: 1541 KTSQEDFNKTELEKYKQ 1557
++ +D ++ + Q
Sbjct: 1147 ASAVQDHDQIVTSRKSQ 1163
>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
Length = 1524
Score = 486 bits (1252), Expect = e-137
Identities = 327/887 (36%), Positives = 492/887 (55%), Gaps = 107/887 (12%)
Query: 475 EDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQ 534
E TR V P + LK + +DSVPN A KD Q S + A +
Sbjct: 701 EKTRTVSSP--------KQPALKAICDKEDSVPNMATEKKDEQISGTVSCQKQPALKATS 752
Query: 535 EREGSENNQP-QVEEERKKHRNNEMEVSA---------NIHDGATDDAEDDDDDDGLIQK 584
+++ S +N P ++++ ++ + + A ++ + AT+ + G+++
Sbjct: 753 DKKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTGILEY 812
Query: 585 RKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFG--------- 635
+ D Q K S+G + Q + + +K+ S ++ + + G
Sbjct: 813 TFNVMFD--QIEEKFTSLNKSAGVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGTEYP 870
Query: 636 ------------KASLLTGGLLQVDDDSS------LSEIDEDEGRPTKKTSNEKNKVKNQ 677
K S+L D +S L E E + ++ N + +VKNQ
Sbjct: 871 ENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQ 930
Query: 678 IQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCER 737
I S DD+DD+ QSS+T SED + + KN +LLI+Q M+CKD V LLKI++ +R
Sbjct: 931 IHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKR 990
Query: 738 LLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQ 797
L++LK NHCE L VKI+K+++K +VLQ+ +S + E K + + E+ L L
Sbjct: 991 LIKLKDNHCEQLRVKIRKLKNKASVLQKRIS-------EKEEIKSQLKHEILELEKELCS 1043
Query: 798 EEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQE 857
+R +++++++ R EV Q++ L+ E + R +++++ + ++
Sbjct: 1044 --------------LRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYR-IEADVTKPIKP 1088
Query: 858 RNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSML 917
K E+E+ NS +E++DL H+N ++
Sbjct: 1089 A-------------------------LKSAEVELKTGGNNSNQVSETDEKEDLLHENRLM 1123
Query: 918 QEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGR 977
Q+EIA LRLE DTIKNQN EK K +D +IVK K+EDLQK +K+N ETL +TI+ Y+G+
Sbjct: 1124 QDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQ 1181
Query: 978 LSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA 1037
L+ LT EN L SKLE +++S++RLE E++SYH RL AA D DQS +SKR+ ELAFQ
Sbjct: 1182 LAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 1241
Query: 1038 RDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERV 1097
D+C LQ+ +N V ILS QL K ESK L+ E H+T +AL+EK L E V
Sbjct: 1242 VDKCRHLQENLNSHVL-------ILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHV 1294
Query: 1098 QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKA 1157
Q +L Q Q QMK++E+ Y++ + K I KQE R QL+ +NMLL+QQLDDA NKA
Sbjct: 1295 QSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQE----RFCQLKKQNMLLQQQLDDARNKA 1350
Query: 1158 DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
DN+EK ++NIQ + A VQ LQAE K LLLEE NK L++E NH KE++ QYE EKAER
Sbjct: 1351 DNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 1410
Query: 1218 EVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRH 1277
EV VRQLQQ+ D L K S ++A L+ +SR+ LE+ QD +KKL Q+R+Q QE QD+
Sbjct: 1411 EVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQL 1470
Query: 1278 TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1324
T +RC ++M+ QKLE ++ ++ +KKQ D+IE L+K L +++L
Sbjct: 1471 TATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSL 1517
Score = 85.5 bits (210), Expect = 4e-16
Identities = 267/1386 (19%), Positives = 531/1386 (38%), Gaps = 193/1386 (13%)
Query: 269 DTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSI 328
+++N+ +P T SQQS +NL+A G +T N +FED++ D + ++LP T
Sbjct: 137 ESENISEPYFTNRRTISQQSAENLDAACGIDKTENGNMFEDQNVDKEG----KALPATGQ 192
Query: 329 KVQ-------CFSHPTYQSPDLLPK---------PSHKSLANPGL----MKE-EPTKPGI 367
K F+H + + S +S P L +KE +P+
Sbjct: 193 KANVSPEQPPLFTHTVKDRDHISTRFLGGMDSLTSSEESSERPPLSTLTLKEADPSSKAA 252
Query: 368 AKKEN----GIDIIESAPLEQTNNDNLTYVDEV--------------------------H 397
++++ G + P E+ +D+ V +
Sbjct: 253 MRRKDSPPPGKVSSQKQPAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSDE 312
Query: 398 KNNRSDMMSALGLGQEEDIESPWDSESISENFPQK--YVDPLAGAADGKEKNIGNEQAED 455
K++ S++ + + GQ+ SP + F +K ++ G + + Q +
Sbjct: 313 KDSVSNIATEIKKGQQSGTVSPQKQSAWKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQP 372
Query: 456 VFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKD 515
S + S +++D G V+ + P LK T + +DSV N A +KD
Sbjct: 373 ASKATSDKTDSALNIATEIKDGLQCG-TVSSQKQPA----LKATTDEEDSVSNIATEIKD 427
Query: 516 VQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDD 575
+ S + A + + + S +N ++ +K VS+ T ++++
Sbjct: 428 GEKSGTVSSQKQPALKATTDEKDSVSNIATEIKDGEKSGT----VSSQKPPALTATSDEE 483
Query: 576 DDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTS-KESVNSPVF 634
+ ++ K GE RK+ A+S + +K+ S K S P
Sbjct: 484 GSVLSIARENKDGEKSRTVSSRKKPALKATSDEKDSFSNITRGKKDGEISRKVSSQKPPT 543
Query: 635 GKA------SLLTGGLLQVDDDSSLSEIDEDEGRP-TKKTSNEKNKVKNQIQSMDDVDDL 687
K S+L G+ + + D S E P K +S EK+ V N + D +
Sbjct: 544 LKGTSDEEDSVL--GIARENKDGEKSRTVSSEKPPGLKASSAEKDSVLNIARGKKDGEKT 601
Query: 688 TQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCE 747
+ S E +F + E KD K+ S ++ LK E
Sbjct: 602 KRVSSRKKPSLEATSDEKDSF----SNITREKKDGEISRKV-----SSQKPPALKGTSDE 652
Query: 748 LLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADT 807
+V E+K R +S K L+ E + L R ++ EK R +
Sbjct: 653 EDSVLGIARENKDGEKSRTVSSEK--PPGLKATSDEKDSVLNIARG--KKDGEKTRTVSS 708
Query: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 867
+ + + KE+ K+ ++S TV ++ +D + +S
Sbjct: 709 PKQPALKAICDKEDSVPNMATEKKDEQIS--------GTVSCQKQPALKATSDKKDSVSN 760
Query: 868 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN-SHSHEEEKDLSHKNSMLQEEIAMLRL 926
++DG + +S QK+ + ++ S+ E KD + + +L
Sbjct: 761 IPTE--IKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGT------GILEY 812
Query: 927 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENA 986
+ + +Q +EK + + +K + QK I + + +L ++ G T
Sbjct: 813 TFNVMFDQIEEKFTSLNKSAGVSPQK-QSAQKVIFKKKVSLLNIATRITGGWKSGT---- 867
Query: 987 MLNSKLENEKQSKERLEAEVESYHSRL--AAAIHDRDQSETSKRELELAFQRARDECSRL 1044
++ L+A +E+ +S L A + D S ++++LE+A + E RL
Sbjct: 868 -------EYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMA---SEGEQKRL 917
Query: 1045 QDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQT 1104
++ N N + Q+ H+RD L + + V +D
Sbjct: 918 EEYEN--------NQPQVKNQI---------------HSRDDLDDIIQSSQTVSEDGDSL 954
Query: 1105 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTV 1164
C K + ++K + L ++++ L ++ + N + +
Sbjct: 955 CCNCKNVILLIDQHEMKCKDCV--------HLLKIKNTFCLWKRLIKLKDNHCEQLRVKI 1006
Query: 1165 INIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQL 1224
++++ +++QK +E E+ L+ EL E L+ Q + ++ E V +++
Sbjct: 1007 RKLKNK-ASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKV 1065
Query: 1225 QQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1284
+++L T ++Q EA +VT + L+ +LK G NQ+ E D + +
Sbjct: 1066 REKLRIT-EEQYRIEA--DVTKPIKPALKSAEVELKTG-GNNSNQVSET-DEKEDLLHEN 1120
Query: 1285 EKMQDH--KQKLEKDNAKLKVTVKKQMD-------KIEELQKNLLN-----ANLSEDEKE 1330
MQD + +LEKD K + KK + K E+LQK L A
Sbjct: 1121 RLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSG 1180
Query: 1331 QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKT 1390
QL L + +L L+++ + LE E+ + +LN H +
Sbjct: 1181 QLAALTDENTTLRSKLEKQRESRQRLETEMQSY-------HCRLNAARCDHDQSHSSKRD 1233
Query: 1391 SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKLQK 1449
+ ++K +H ++L + + + ++K+++L+ EL + + +++K +
Sbjct: 1234 QELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEH 1293
Query: 1450 NKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQE 1509
+ +L+Q+ ++ +E Y + +QE +LK+ N+ LQ Q
Sbjct: 1294 VQSELKQKQSQMKD------IEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDAR 1347
Query: 1510 NLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNK---TEL--EKYKQLYLEELK 1564
N +E +++++ + R+++L++E K + E+ NK EL K K+ E+ K
Sbjct: 1348 NKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEK 1407
Query: 1565 VRKSLS 1570
+ ++
Sbjct: 1408 AEREVA 1413
Score = 58.9 bits (141), Expect = 4e-08
Identities = 103/555 (18%), Positives = 218/555 (39%), Gaps = 69/555 (12%)
Query: 581 LIQKRKSGETDHQQFPRKE----NKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGK 636
++QKR S + + + + E KE S A+Q EK+KR + E V+ V K
Sbjct: 1015 VLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQ------EKKKRRNVEEVHQKVREK 1068
Query: 637 ASLLTGGLLQVDDDSSLSEIDEDEG-RPTKKTSNEKNKV----KNQIQSMDDVDDLTQSS 691
L++ ++ E D + +P K++ + K NQ+ D+ +DL +
Sbjct: 1069 --------LRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHEN 1120
Query: 692 ETASEDC---ELPHSSYKNFMLLIEQLGMECKD-SVSLLKIQDAALSCERLLELKKNHCE 747
++ L + KN L + L KD + K +D + +R E
Sbjct: 1121 RLMQDEIARLRLEKDTIKNQNLEKKYL----KDFEIVKRKHEDLQKALKRNGETLAKTIA 1176
Query: 748 LLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADT 807
+ ++ + D+ L+ +L + +E + +LE + + L + R +Q +R+ +
Sbjct: 1177 CYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQEL 1236
Query: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 867
++ ++ R +E V + L L L E + R +K+ L+ + +
Sbjct: 1237 AFQGTVDKCRHLQENLNSHVLI---LSLQLSKAESKSRVLKTELHYTGEALKEKALVFEH 1293
Query: 868 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLE 927
Q+ L S+ K+IE KM ++ E+ + + L+++ +L+ +
Sbjct: 1294 VQSE-------LKQKQSQMKDIE----KMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQ 1342
Query: 928 IDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAM 987
+D +N+ +EK + ++LQ +++ L + +N M
Sbjct: 1343 LDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEE--------------DNKM 1388
Query: 988 LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK 1047
L ++L + K+ + + E E + RD + + C+ L++
Sbjct: 1389 LVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENG 1448
Query: 1048 MNFD---VSNLKDNNEILSQQLFKT-------ESKLNSLEIEFHHTRDALREKTLGLERV 1097
M + ++ + + QL T E LE+E R ++++ +ER+
Sbjct: 1449 MQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERL 1508
Query: 1098 QKDLSQTQCQMKEME 1112
+K L + ++ E
Sbjct: 1509 EKILQHSSLMLQVFE 1523
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 469 bits (1207), Expect = e-131
Identities = 415/1295 (32%), Positives = 604/1295 (46%), Gaps = 240/1295 (18%)
Query: 64 QILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
+ LL + N ++ TAL LA G E+V +L+ + + D TA A C
Sbjct: 189 EFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQNVDVFAEDIHGITAERYAAAC 248
Query: 124 QEEKCATILLEH----GADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
LLEH +P + G + +E +A + ++ K D+
Sbjct: 249 GVNYIHQQLLEHIRKLPKNPQNTNPEGTST---GTPDEAAPLAERTPDTAESLLEKTPDE 305
Query: 180 LTPLL-----------LAVSGKKQQMVEFLIKK--KANVNAVDKL-----ESSHQLISEY 221
L+ A SGK +Q E +K + +K E S ++ E
Sbjct: 306 AARLVEGTSAKIQCLGKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEE 365
Query: 222 KEERIPKH----------------------------SSQNSNSVDESSEDSLSRLSGKPG 253
KE + S++ S +VD SS + + L G
Sbjct: 366 KETSVKTECVAGVTPNKTEVLEKGTSNMIACPTKETSTKASTNVDVSSVEPIFSLFGTRT 425
Query: 254 VDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGT-VRTGNRTLFED--- 309
+++S T +ED N TK + K +A+Q +ATY ++T N + +
Sbjct: 426 IENSQCTKVEEDFNLATKIISK-------SAAQNYTCLPDATYQKDIKTINHKIEDQMFP 478
Query: 310 ----RDSDSQDEVVVESLPTTSIKVQ-CFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTK 364
R+ D + SL +S K Q C YQ K + ++E P K
Sbjct: 479 SESKREEDEEYSWDSGSLFESSAKTQVCIPESMYQ----------KVMEINREVEELPEK 528
Query: 365 PGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSES 424
P K +++ ++ P N + + + R+ M Q++D E+ WDSES
Sbjct: 529 PSAFKP--AVEMQKTVP-------NKAFELKNEQTLRAAQMFPSESKQKDDEENSWDSES 579
Query: 425 ISENFPQKYV-----------DPLAGAAD-------------GKEKNIGNEQAE------ 454
E QK V D L+G + G++ ++ N+ E
Sbjct: 580 PCETVSQKDVYLPKATHQKEFDTLSGKLEESPVKDGLLKPTCGRKVSLPNKALELKDRET 639
Query: 455 --------DVFYIPSC-MSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDS 505
D P+C S K +L+D + ESP+ LKPT K S
Sbjct: 640 FKAESPDKDGLLKPTCGRKVSLPNKALELKDRETL-----KAESPDNDGLLKPTCGRKVS 694
Query: 506 VPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIH 565
+PNKA +KD +T KAA+ E +++ E N E + N++ + H
Sbjct: 695 LPNKALELKDRETFKAAQ-----MFPSESKQKDDEENSWDFESFLETLLQNDVCLPKATH 749
Query: 566 ----DGATDDAEDDDDDDGLIQK---------RKSGETDHQQFPRKENKEYASSGPAL-- 610
D + E+ D DGL++ K+ E ++ + E+ S +L
Sbjct: 750 QKEFDTLSGKLEESPDKDGLLKPTCGMKISLPNKALELKDRETFKAEDVSSVESTFSLFG 809
Query: 611 -----QMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRP-- 663
+ K E T+KE V G+ G + + D + + GR
Sbjct: 810 KPTTENSQSTKVEEDFNLTTKEGATKTVTGQQERDIGIIERAPQDQTNKMPTSELGRKED 869
Query: 664 TKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYK--------NFMLLIEQL 715
TK TS+ + + Q+ + + + T E + + ++ S K +
Sbjct: 870 TKSTSDSEIISVSDTQNYECLPEATYQKEIKTTNGKIEESPEKPSHFEPATEMQNSVPNK 929
Query: 716 GMECK-------DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELS 768
G+E K DS +L KI DA SCER ELKK++CE +T K+++ ++K VLQ+ELS
Sbjct: 930 GLEWKNKQTLRADSTTLSKILDALPSCERGRELKKDNCEQITAKMEQTKNKFCVLQKELS 989
Query: 769 ETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVE 828
E KEIKSQLE+QK +WE+ELCS+R +LNQEEEKRRN D L EKIR EEQ RK++E
Sbjct: 990 EAKEIKSQLENQKAKWEQELCSVRLTLNQEEEKRRNVDILKEKIRP-----EEQLRKKLE 1044
Query: 829 VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKE 888
VKQQLE +L+ ++EL++V SNLNQV
Sbjct: 1045 VKQQLEQTLRIQDIELKSVTSNLNQV---------------------------------- 1070
Query: 889 IEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKI 948
SH+HE E DL H+N ML++EIAML+LE+ T+K+Q+Q KE K FED+KI
Sbjct: 1071 ------------SHTHESENDLFHENCMLKKEIAMLKLEVATLKHQHQVKENKYFEDIKI 1118
Query: 949 VKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1008
++EKN +LQ T+K ++T+T+ SQY +L VLTAEN ML SKL+ EKQ KE LE E+ES
Sbjct: 1119 LQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTAENTMLTSKLK-EKQDKEILETEIES 1177
Query: 1009 YHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFK 1068
+H RLA+A+ D DQS TS++ ELAF A D + LQ MN DVSN NNE+L Q L++
Sbjct: 1178 HHPRLASALQDHDQSVTSRKNQELAFHSAGD--APLQGIMNVDVSNTIYNNEVLHQPLYE 1235
Query: 1069 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK 1128
+ K S +I ++ D LRE L E Q+D +TQCQMK+ E YQNEQ V+K+ +
Sbjct: 1236 AQRKSKSPKINLNYAGDDLRENALVSEHAQRDRCETQCQMKKAEHMYQNEQDNVDKHTEQ 1295
Query: 1129 QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL 1188
QES+E++L QL+S+N LRQQL AH K NK K INIQ K
Sbjct: 1296 QESLEQKLFQLESKNRWLRQQLVYAHKKV-NKSKVTINIQ-----------FPEMKMQRH 1343
Query: 1189 LEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223
L E+N+E+ + NHLKER QYE EKAEREV +++
Sbjct: 1344 LNEKNEEVFNYGNHLKERIDQYEKEKAEREVSIKK 1378
Score = 259 bits (661), Expect = 2e-68
Identities = 356/1517 (23%), Positives = 595/1517 (39%), Gaps = 272/1517 (17%)
Query: 18 RRQRSSAGGG--GEPGEGAYSQPGYHVRDR------DLGKIHKAASAGNVAKVQQILLLR 69
+R ++AG G G +S+ Y +D DLGKIH AAS G V K++++ + +
Sbjct: 2 KRLLAAAGKGVRGPEPPNPFSERVYTEKDYGTIYFGDLGKIHTAASRGQVQKLEKMTVGK 61
Query: 70 KN-GLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
K LN RD RTALH AC NGH EVVT LVDRKCQLNV D E RT LMKA+QC+ E C
Sbjct: 62 KPVNLNKRDMKKRTALHWACVNGHAEVVTFLVDRKCQLNVLDGEGRTPLMKALQCEREAC 121
Query: 129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVS 188
A IL++ GAD N DV+GNTALHYAVY+E++ + LL Y A IE +NK LTPLLLA+
Sbjct: 122 ANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQ 181
Query: 189 GKKQQMVEFLIKKKANVNAVDKLESSHQL--ISEYKEERIPKHSSQNSNSVDESSED--- 243
+ +Q VEFL+ K AN NA ++ + + + I E E + QN VD +ED
Sbjct: 182 KRSKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQN---VDVFAEDIHG 238
Query: 244 -SLSRLSGKPGVD----------------------DSWPTSDDEDLNFDTKNVPKPSLAK 280
+ R + GV+ + T ++ + P + +
Sbjct: 239 ITAERYAAACGVNYIHQQLLEHIRKLPKNPQNTNPEGTSTGTPDEAAPLAERTPDTAESL 298
Query: 281 LMTASQQSRKNLEATYGTVR-TGNRT--LFEDRDSDSQDEVVVESLPT------------ 325
L ++ + +E T ++ G T FE ++ +++ + T
Sbjct: 299 LEKTPDEAARLVEGTSAKIQCLGKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERS 358
Query: 326 ---------TSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGID- 375
TS+K +C + T ++L K + +A P KE TK + ++
Sbjct: 359 RKITWEEKETSVKTECVAGVTPNKTEVLEKGTSNMIACP--TKETSTKASTNVDVSSVEP 416
Query: 376 ----------------------------IIESAPLEQTNNDNLTYVDEVHKNNR--SDMM 405
I +SA T + TY ++ N D M
Sbjct: 417 IFSLFGTRTIENSQCTKVEEDFNLATKIISKSAAQNYTCLPDATYQKDIKTINHKIEDQM 476
Query: 406 SALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSG 465
+EED E WDS S+ E+ + V C+
Sbjct: 477 FPSESKREEDEEYSWDSGSLFESSAKTQV---------------------------CIPE 509
Query: 466 SRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHD 525
S K+ +E R V E PE+ KP +EM+ +VPNKA +K+ QT +AA+
Sbjct: 510 SMYQKV--MEINREV------EELPEKPSAFKPAVEMQKTVPNKAFELKNEQTLRAAQM- 560
Query: 526 LEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKR 585
S+++ + E S +++ E +K D + E+ DGL++
Sbjct: 561 FPSESKQKDDEENSWDSESPCETVSQKDVYLPKATHQKEFDTLSGKLEESPVKDGLLKPT 620
Query: 586 KSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLL 645
+ P K AL++K+ + T K + K+ + P G+ L L
Sbjct: 621 CGRKV---SLPNK----------ALELKD-RETFKAESPDKDGLLKPTCGRKVSLPNKAL 666
Query: 646 QVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQS----SETASEDCELP 701
++ D +L D K T K + N+ + D + + SE+ +D E
Sbjct: 667 ELKDRETLKAESPDNDGLLKPTCGRKVSLPNKALELKDRETFKAAQMFPSESKQKDDEEN 726
Query: 702 HSSYKNFMLLIEQLGM-------------------ECKDSVSLLKIQDAALSCERLLELK 742
+++F+ + Q + E D LLK +C + L
Sbjct: 727 SWDFESFLETLLQNDVCLPKATHQKEFDTLSGKLEESPDKDGLLK-----PTCGMKISLP 781
Query: 743 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKR 802
EL + K ED +V K + KVE + F+L +E
Sbjct: 782 NKALELKDRETFKAEDVSSVESTFSLFGKPTTENSQSTKVEED-------FNLTTKEGAT 834
Query: 803 RNADTLYEKIREQLRRKEEQYRKEVEVKQ--QLELSLQTLEMELRTVKSNLNQVVQERND 860
+ E+ + R + ++ + + E + T + E+ +V N
Sbjct: 835 KTVTGQQERDIGIIERAPQDQTNKMPTSELGRKEDTKSTSDSEIISVSDTQNYECLPEAT 894
Query: 861 AQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSM-LQE 919
Q+++ +G + K E A + NS K L KN L+
Sbjct: 895 YQKEIK-------TTNGKIEESPEKPSHFEPATEMQNS------VPNKGLEWKNKQTLRA 941
Query: 920 EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLS 979
+ L +D + + + +E K K N E +T + Q +
Sbjct: 942 DSTTLSKILDALPSCERGRELK-------------------KDNCEQITAKMEQTKNKFC 982
Query: 980 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD 1039
VL E L K+ K +LE + + L + +Q E +R +++ ++ R
Sbjct: 983 VLQKE-------LSEAKEIKSQLENQKAKWEQELCSVRLTLNQEEEKRRNVDILKEKIRP 1035
Query: 1040 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQK 1099
E +L+ K+ L+ I +L S LN + D E + ++K
Sbjct: 1036 E-EQLRKKLEVK-QQLEQTLRIQDIELKSVTSNLNQVSHTHESENDLFHENCM----LKK 1089
Query: 1100 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADN 1159
+++ + ++ ++ ++ QVK NKY + ++E+ ++LQ L
Sbjct: 1090 EIAMLKLEVATLKHQH---QVKENKYFEDIKILQEKNAELQMTLKL-------------- 1132
Query: 1160 KEKTVINIQDQFHAIVQKLQAESEK-QSLLLEERNKELIS---ECNHLKERQYQYENEKA 1215
K+KTV Q+ ++ L AE+ S L E+++KE++ E +H + +++++
Sbjct: 1133 KQKTVTKRASQYREQLKVLTAENTMLTSKLKEKQDKEILETEIESHHPRLASALQDHDQS 1192
Query: 1216 EREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQD 1275
++L A Q + + T L + ++K + L A D
Sbjct: 1193 VTSRKNQELAFHSAGDAPLQGIMNVDVSNTIYNNEVLHQPLYEAQRKSKSPKINLNYAGD 1252
Query: 1276 RHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1335
E +E Q +D + + QM K E + +N E++ + K
Sbjct: 1253 DLRENALVSEHAQ-------RDRCETQC----QMKKAEHMYQN---------EQDNVDKH 1292
Query: 1336 MELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEM 1395
E ++SLE L Q KN L +++ + ++ +N + E L E+
Sbjct: 1293 TEQQESLEQKLFQLESKNRWLRQQLVYAHKKVNKSKVTIN-IQFPEMKMQRHLNEKNEEV 1351
Query: 1396 DIQINKLKHKIDDLTAE 1412
N LK +ID E
Sbjct: 1352 FNYGNHLKERIDQYEKE 1368
Score = 60.8 bits (146), Expect = 1e-08
Identities = 154/765 (20%), Positives = 299/765 (39%), Gaps = 98/765 (12%)
Query: 754 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIR 813
+ M KV + RE+ E E S + VE ++ + + F L E+ R A ++
Sbjct: 509 ESMYQKVMEINREVEELPEKPSAFK-PAVEMQKTVPNKAFELKNEQTLR--AAQMFPSES 565
Query: 814 EQLRRKEEQYRKE--VEVKQQLELSLQ--TLEMELRTVKSNLNQVVQERNDAQRQLSREQ 869
+Q +E + E E Q ++ L T + E T+ L +
Sbjct: 566 KQKDDEENSWDSESPCETVSQKDVYLPKATHQKEFDTLSGKLEE---------------- 609
Query: 870 NARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEID 929
++DG+L ++ + + K + ++ + + E K+ +L+
Sbjct: 610 --SPVKDGLLKPTCGRK--VSLPNKALELKDRETFKAESP--DKDGLLKPTCGR------ 657
Query: 930 TIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN 989
+ N+ E K E LK N+ L K + +L + R + A+
Sbjct: 658 KVSLPNKALELKDRETLKAESPDNDGLLKPTCGRKVSLPNKALELKDRETFKAAQMFPSE 717
Query: 990 SKLENEKQSKERLEAEVESYHSR---LAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1046
SK ++++++ E+ +E+ L A H ++ S + + + D+ L+
Sbjct: 718 SKQKDDEENSWDFESFLETLLQNDVCLPKATHQKEFDTLSGK-----LEESPDKDGLLKP 772
Query: 1047 KMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQC 1106
+S E+ ++ FK E ++S+E F E + +V++D + T
Sbjct: 773 TCGMKISLPNKALELKDRETFKAED-VSSVESTFSLFGKPTTENSQST-KVEEDFNLT-- 828
Query: 1107 QMKEMEQKYQNEQVKVNKYIGKQE---SVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1163
++ G+QE + ER Q Q+ N + +L + +
Sbjct: 829 ----------TKEGATKTVTGQQERDIGIIERAPQDQT-NKMPTSELGRKEDTKSTSDSE 877
Query: 1164 VINIQD--QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVV 1221
+I++ D + + + + K + E + E S E Q N+ E
Sbjct: 878 IISVSDTQNYECLPEATYQKEIKTTNGKIEESPEKPSHFEPATEMQNSVPNKGLEW---- 933
Query: 1222 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1281
+ Q AD+ + +A L R R +D + + K+ Q +N+ Q +EA
Sbjct: 934 KNKQTLRADSTTLSKILDA-LPSCERGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAK 992
Query: 1282 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS 1341
++++ K K E++ +++T+ ++ EE ++N+ +EQL+K +E+KQ
Sbjct: 993 EIKSQLENQKAKWEQELCSVRLTLNQE----EEKRRNVDILKEKIRPEEQLRKKLEVKQQ 1048
Query: 1342 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINK 1401
LE L +++EL + +T N + T +E EN F + LK + +++
Sbjct: 1049 LEQTL---RIQDIEL-KSVTSNLNQVSHT----HESENDLFHENCMLKKEIAMLKLEVAT 1100
Query: 1402 LKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKLQK----------- 1449
LKH+ + L KN LQ L L KTV K+ + ++
Sbjct: 1101 LKHQHQ---VKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTAENTM 1157
Query: 1450 --NKKKLEQEVINLRSHIERNMVELGQVKQ-YKQEIEERARQEIA 1491
+K K +Q+ L + IE + L Q + Q + R QE+A
Sbjct: 1158 LTSKLKEKQDKEILETEIESHHPRLASALQDHDQSVTSRKNQELA 1202
>gi|124517695 ankyrin repeat domain 36B [Homo sapiens]
Length = 1121
Score = 456 bits (1174), Expect = e-128
Identities = 320/926 (34%), Positives = 487/926 (52%), Gaps = 106/926 (11%)
Query: 444 KEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNV--GMPVAHMESPERYLHLKPTIE 501
+EK G + F P + +R+ K + L R G + S + LK T +
Sbjct: 250 REKKDGEKSRTVSFEQPPGLKATRDEKDSLLNIARGKKDGEKTRRVSS-HKQPSLKATSD 308
Query: 502 MKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKH-------- 553
+DSVPN A KD Q S + A + +++ S +N P ++ ++
Sbjct: 309 KEDSVPNMATETKDEQISGTVSCQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQ 368
Query: 554 ---------RNNEMEVSANIHDGAT-------------DDAEDDDDDDGLIQKRKSGETD 591
+++ ++ I DG ++ D + ++ K GE
Sbjct: 369 PAWKATSVKKDSVSNIATEIKDGQIRGTVSSQRRPALKTTGDEKDSVSNIAREIKDGEKS 428
Query: 592 HQQFPRKENKEYASSGPALQMKEVKS---------TE--KEKRTSKESVNSP--VFGKAS 638
P+K++ + + + + + TE + RT K ++ + V A+
Sbjct: 429 GTVSPQKQSAQKVIFKKKVSLLNIATRITGGGKSGTEYPENLRTLKATIENKDSVLNTAT 488
Query: 639 LLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDC 698
+ + L E E + ++ N + +VKNQI S DD+DD+ QSS+T SED
Sbjct: 489 KMKEVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDG 548
Query: 699 ELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMED 758
+ + KN +LLI+Q M+CKD V LLKI++ +RL IK ++
Sbjct: 549 DSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRL--------------IKLKDN 594
Query: 759 KVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRR 818
L+ ++ + K S L+ + E E L+ + + E++ + ++ +++ R
Sbjct: 595 HCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRN 654
Query: 819 KEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI 878
EE ++K V+++L ++ + +E K
Sbjct: 655 VEELHQK---VREKLRITEEQYRIEADVTKP----------------------------- 682
Query: 879 LTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK 938
K E+E+ NS +E++DL H+N ++Q+EIA LRLE DTIKNQN EK
Sbjct: 683 -IKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK 741
Query: 939 EKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQS 998
K +D +IVK K+EDLQK +K+N ETL +TI+ Y+G+L+ LT EN L SKLE +++S
Sbjct: 742 --KYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRES 799
Query: 999 KERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDN 1058
++RLE E++SY RL AA D DQS +SKR+ ELAFQ D+C LQ+ +N V
Sbjct: 800 RQRLETEMQSYRCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL----- 854
Query: 1059 NEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1118
ILS QL K ESK L+ E H+T +AL+EK L E VQ +L Q Q QMK++E+ Y++
Sbjct: 855 --ILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSG 912
Query: 1119 QVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKL 1178
+ K I KQE R QL+ +NMLL+QQLDDA NKADN+EK ++NIQ + A VQ L
Sbjct: 913 YNTMEKCIEKQE----RFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNL 968
Query: 1179 QAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1238
QAE K LLLEE NK L++E NH KE++ QYE EKAEREV VRQLQQ+ D L K S +
Sbjct: 969 QAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSAT 1028
Query: 1239 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDN 1298
+A L+ +SR+ LE+ QD +KKL Q+R+Q QE QD+ T +RC ++M+ QKLE ++
Sbjct: 1029 KALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEH 1088
Query: 1299 AKLKVTVKKQMDKIEELQKNLLNANL 1324
++ +KKQ D+IE L+K L +++L
Sbjct: 1089 VMMRKIIKKQDDQIERLEKILQHSSL 1114
Score = 57.8 bits (138), Expect = 9e-08
Identities = 102/555 (18%), Positives = 218/555 (39%), Gaps = 69/555 (12%)
Query: 581 LIQKRKSGETDHQQFPRKE----NKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGK 636
++QKR S + + + + E KE S A+Q EK+KR + E ++ V K
Sbjct: 612 VLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQ------EKKKRRNVEELHQKVREK 665
Query: 637 ASLLTGGLLQVDDDSSLSEIDEDEG-RPTKKTSNEKNKV----KNQIQSMDDVDDLTQSS 691
L++ ++ E D + +P K++ + K NQ+ D+ +DL +
Sbjct: 666 --------LRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHEN 717
Query: 692 ETASEDC---ELPHSSYKNFMLLIEQLGMECKD-SVSLLKIQDAALSCERLLELKKNHCE 747
++ L + KN L + L KD + K +D + +R E
Sbjct: 718 RLMQDEIARLRLEKDTIKNQNLEKKYL----KDFEIVKRKHEDLQKALKRNGETLAKTIA 773
Query: 748 LLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADT 807
+ ++ + D+ L+ +L + +E + +LE + + L + R +Q +R+ +
Sbjct: 774 CYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYRCRLNAARCDHDQSHSSKRDQEL 833
Query: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 867
++ ++ R +E V + L L L E + R +K+ L+ + +
Sbjct: 834 AFQGTVDKCRHLQENLNSHVLI---LSLQLSKAESKSRVLKTELHYTGEALKEKALVFEH 890
Query: 868 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLE 927
Q+ L S+ K+IE KM ++ E+ + + L+++ +L+ +
Sbjct: 891 VQSE-------LKQKQSQMKDIE----KMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQ 939
Query: 928 IDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAM 987
+D +N+ +EK + ++LQ +++ L + +N M
Sbjct: 940 LDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEE--------------DNKM 985
Query: 988 LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK 1047
L ++L + K+ + + E E + RD + + C+ L++
Sbjct: 986 LVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENG 1045
Query: 1048 MNFD---VSNLKDNNEILSQQLFKT-------ESKLNSLEIEFHHTRDALREKTLGLERV 1097
M + ++ + + QL T E LE+E R ++++ +ER+
Sbjct: 1046 MQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERL 1105
Query: 1098 QKDLSQTQCQMKEME 1112
+K L + ++ E
Sbjct: 1106 EKILQHSSLMLQVFE 1120
Score = 43.5 bits (101), Expect = 0.002
Identities = 153/804 (19%), Positives = 314/804 (39%), Gaps = 144/804 (17%)
Query: 840 LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 899
L +EL K + + D+ ++ E +++G ++ +S QK+ A+K +
Sbjct: 19 LRIELSPQKQRAEKATSDDKDSVSNIATE-----IKEGPISGTVSSQKQ--PAEKATS-- 69
Query: 900 NSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED----LKIVKE-KNE 954
+E+ +S+ + ++E + T+ Q Q +K F+ L I
Sbjct: 70 -----DEKDSVSNIATEIKEG-----QQSGTVSPQKQSAQKVIFKKKVSLLNIATRIMGG 119
Query: 955 DLQKTIKQNEETLTQTIS-QYNGRLSVLTA-ENAMLNSKLENEKQSKERLEAEVESYHSR 1012
T+ ++ ++T S + + L+ T ++ + + ++KQ + + E S
Sbjct: 120 GKSGTVSSQKQPASKTASDKTDSALNTATEIKDGLQCGTVSSQKQQALKATTDEEGSVSN 179
Query: 1013 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 1072
+A I D ++S T + + A + DE +D + +++ K + EI +
Sbjct: 180 IATEIKDGEKSGTVSSQKKPALKATSDE----KDSFS-NITREKKDGEISRTVSSQKPPA 234
Query: 1073 LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESV 1132
L + ++ + REK G +K + + Q ++ + +N GK++
Sbjct: 235 LKATSVKEDSVLNIAREKKDG----EKSRTVSFEQPPGLKATRDEKDSLLNIARGKKDG- 289
Query: 1133 EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLL 1189
E+ ++ S + D + N + Q QK L+A S+K
Sbjct: 290 -EKTRRVSSHKQPSLKATSDKEDSVPNMATETKDEQISGTVSCQKQPALKATSDK----- 343
Query: 1190 EERNKELISEC-NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV---- 1244
K+ +S +K+ Q Q ++++ + A ++KK S+S + E+
Sbjct: 344 ----KDSVSNIPTEIKDGQ-QSGTVSSQKQPAWK------ATSVKKDSVSNIATEIKDGQ 392
Query: 1245 ----TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK 1300
S R T D K + I ++++ + T + KQ +K K
Sbjct: 393 IRGTVSSQRRPALKTTGDEKDSVSNIAREIKDGEKSGT--------VSPQKQSAQKVIFK 444
Query: 1301 LKVTVKKQMDKIE-------ELQKNLLNANLSEDEKEQL----KKLMELKQSLECNLDQE 1349
KV++ +I E +NL + + K+ + K+ E++ S D E
Sbjct: 445 KKVSLLNIATRITGGGKSGTEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLE 504
Query: 1350 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD- 1408
M E +K+L EYEN + + S+ ++D I + +D
Sbjct: 505 MASEGE---------------QKRLEEYENNQPQVKNQIH-SRDDLDDIIQSSQTVSEDG 548
Query: 1409 ------------LTAELETAGSKCLHL-DTKNQI-LQEELLSMKTVQKKCEKLQKNKKKL 1454
L + E C+HL KN L + L+ +K CE+L+ +KL
Sbjct: 549 DSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLK--DNHCEQLRVKIRKL 606
Query: 1455 EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKE---VNLFLQAQAASQENL 1511
+ + L+ I K+EI+ + + EI E KE + +Q + + N+
Sbjct: 607 KNKASVLQKRISE-----------KEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNV 655
Query: 1512 EQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSS 1571
E+ + K + +LRI + + + + D K K + ELK + S+
Sbjct: 656 EELHQ------KVREKLRITEEQYRI------EADVTKPIKPALKSAEV-ELKTGGNNSN 702
Query: 1572 KLTKTNERLAEVNTKLLVEKQQSR 1595
++++T+E+ ++ L++ + +R
Sbjct: 703 QVSETDEKEDLLHENRLMQDEIAR 726
>gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Homo
sapiens]
Length = 475
Score = 410 bits (1053), Expect = e-114
Identities = 238/503 (47%), Positives = 325/503 (64%), Gaps = 60/503 (11%)
Query: 721 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ 780
D V LLKI++ +RL++LK NHCE L VKI+K+++K +VLQ+ +SE +EIKSQL+H+
Sbjct: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
Query: 781 KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL 840
+E E+ELCSLRF++ QE++KRRN + L++K+RE+LR EEQYR E +V + ++ +L++
Sbjct: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
Query: 841 EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN 900
E+EL+T +N NQV D + L E R++QD
Sbjct: 144 EVELKTGGNNSNQV--SETDEKEDLLHEN--RLMQD------------------------ 175
Query: 901 SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI 960
EIA LRL+ DTIKNQN EKK +D +IVK K+EDLQK +
Sbjct: 176 -------------------EIARLRLDTDTIKNQN--LEKKYLKDFEIVKRKHEDLQKAL 214
Query: 961 KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
K+N ETL +TI+ Y+G+L+ LT EN L SKLE +++S++RLE E++SYH RL AA D
Sbjct: 215 KRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDH 274
Query: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
DQS +SKR+ ELAFQ D+C LQ+ +N V ILS QL K ESK L+ E
Sbjct: 275 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------ILSLQLSKAESKSRVLKTEL 327
Query: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
H+T +AL+EK L E VQ +L Q Q QMK++E+ Y++ + K I KQ ER QL+
Sbjct: 328 HYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLK 383
Query: 1141 SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC 1200
+NMLL+QQLDDA NKADN+EK ++NIQ + A VQ LQAE K LLLEE NK L++E
Sbjct: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
Query: 1201 NHLKERQYQYENEKAEREVVVRQ 1223
NH KE++ QYE EKAEREV +++
Sbjct: 444 NHSKEKECQYEKEKAEREVSIKK 466
Score = 62.0 bits (149), Expect = 5e-09
Identities = 85/433 (19%), Positives = 187/433 (43%), Gaps = 53/433 (12%)
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
L + ++L + LK + + +E+E + QL+ E+ + K+ +++ +
Sbjct: 44 LKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKK 103
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
R N+E+ Q +++KL +I + + T+ ++ A K + + K +N+ +
Sbjct: 104 KRRNVEELHQKVREKL-RITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE 162
Query: 1308 QMDKIEE---LQKNLLNANLSED-------EKEQLKKLMELKQSLECNLDQEMKKNVE-- 1355
+ D + E +Q + L D EK+ LK +K+ E +L + +K+N E
Sbjct: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHE-DLQKALKRNGETL 221
Query: 1356 -------------LEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ---- 1398
L E T ++ L+ R+ E S+H L ++ + D
Sbjct: 222 AKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSK 281
Query: 1399 ----------INKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKL 1447
++K +H ++L + + + ++K+++L+ EL + + +++K
Sbjct: 282 RDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVF 341
Query: 1448 QKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAAS 1507
+ + +L+Q+ ++ +E Y + +QE +LK+ N+ LQ Q
Sbjct: 342 EHVQSELKQKQSQMKD------IEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDD 395
Query: 1508 QENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNK---TEL--EKYKQLYLEE 1562
N +E +++++ + R+++L++E K + E+ NK EL K K+ E+
Sbjct: 396 ARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEK 455
Query: 1563 LKVRKSLSSKLTK 1575
K + +S K K
Sbjct: 456 EKAEREVSIKKNK 468
Score = 32.3 bits (72), Expect = 4.1
Identities = 43/190 (22%), Positives = 86/190 (45%), Gaps = 31/190 (16%)
Query: 1420 CLHL-DTKNQI-LQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477
C+HL KN L + L+ +K CE+L+ +KL+ + L+ I
Sbjct: 25 CVHLLKIKNTFCLWKRLIKLK--DNHCEQLRVKIRKLKNKASVLQKRISE---------- 72
Query: 1478 YKQEIEERARQEIAEKLKE---VNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE 1534
K+EI+ + + EI E KE + +Q + + N+E+ + K + +LRI + +
Sbjct: 73 -KEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQ------KVREKLRITEEQ 125
Query: 1535 SELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQS 1594
+ + D K K + ELK + S+++++T+E+ ++ L++ + +
Sbjct: 126 YRI------EADVTKPIKPALKSAEV-ELKTGGNNSNQVSETDEKEDLLHENRLMQDEIA 178
Query: 1595 RSLFTTLTTR 1604
R T T +
Sbjct: 179 RLRLDTDTIK 188
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 395 bits (1016), Expect = e-109
Identities = 277/828 (33%), Positives = 454/828 (54%), Gaps = 102/828 (12%)
Query: 838 QTLEMELRTVKSNLNQVVQERNDAQRQLS-REQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Q LE + + +K++L RND Q + + N + ++ H K E ++
Sbjct: 358 QILEHKNKMLKNHL------RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQ 411
Query: 897 NSEN-----SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKE 951
SEN S S+ ++KD + N ML+++IAML+ E+ IKN + KEKK +++K + E
Sbjct: 412 RSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 471
Query: 952 KNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHS 1011
N + +K+++ NE+ +T+T+++Y+ +L+ L AENA LNS+LE EK
Sbjct: 472 INANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK--------------- 516
Query: 1012 RLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTES 1071
H++++ E L + A + + NEI+ ++
Sbjct: 517 ------HNKERLEAEVESLHSSLATA-----------------INEYNEIVERK------ 547
Query: 1072 KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK--- 1128
LE+ D R + +G ++SQ + + + ++ +VK N GK
Sbjct: 548 ---DLELVLWRADDVSRHEKMG-----SNISQLTDKNELLTEQVHKARVKFNTLKGKLRE 599
Query: 1129 -QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
++++ E+ L S + LRQ A ++ K + Q H + +++S +
Sbjct: 600 TRDALREKTLALGSVQLDLRQ--------AQHRIKEM----KQMHPNGEAKESQSIGKQN 647
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LEER ++ E N L ERQ + ++ + + +V + ++ + K+ + E + E+
Sbjct: 648 SLEERIRQQELE-NLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 706
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
Y LK+KL Q +E +R E++ DH + + L+ T
Sbjct: 707 YNY--------LKEKLLQCE---KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755
Query: 1308 QMDKIEEL--QKNLLNANLSEDEK-EQLKKLMELKQSLECNLDQEMKKNVELEREITGFK 1364
++ E +K L + +EK E+ +KL EL L DQ KKN ELE E TG+K
Sbjct: 756 HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815
Query: 1365 NLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLD 1424
L+MT LN + N +FS HGDL T Q +MDI KLK K +DL AE E S+C++L
Sbjct: 816 KCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 875
Query: 1425 TKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
N++L +ELLSM+ VQ+KCEKL+K+KK LE+EV+NL++H+E++MVELG++++YK E++E
Sbjct: 876 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 935
Query: 1485 RARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQ 1544
RA QEI EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+
Sbjct: 936 RAVQEI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAY 991
Query: 1545 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1604
E+ TELE++K+ + +K S+S KL K+++++A ++TKL EKQ+ + +TL TR
Sbjct: 992 EEVT-TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTR 1050
Query: 1605 PVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKM 1652
P E PCV NL NS++LNRK IP+ + I TSNP+ SNN +N+L+++
Sbjct: 1051 PEPELPCVENL-NSIELNRKYIPKTAIRIPTSNPQTSNN-CKNFLTEV 1096
Score = 207 bits (527), Expect = 7e-53
Identities = 99/185 (53%), Positives = 140/185 (75%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ PGY +RD +L KIH+AA G+ A+V++ L R L+ RD+ +RT LHLACA+G +
Sbjct: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+ R+CQ+++CD NRT LMKAV QEE CA +LLE GA+PN+ D++GNTALHYAV
Sbjct: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YN+ S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
Query: 215 HQLIS 219
+++
Sbjct: 310 ALILA 314
Score = 70.1 bits (170), Expect = 2e-11
Identities = 150/743 (20%), Positives = 305/743 (41%), Gaps = 94/743 (12%)
Query: 463 MSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAA 522
M G A D R++ + ++ HL+ + +++ K +K + A
Sbjct: 338 MFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKA 395
Query: 523 EHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGL 581
EH+L+VASEE+QER + SEN QPQ + K + D + D L
Sbjct: 396 EHNLKVASEEKQERLQRSENKQPQDSQSYGKKK-----------DAMYGNFMLKKDIAML 444
Query: 582 IQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLT 641
++ + + D RKE K ++E+KS + ++SV ++T
Sbjct: 445 KEELYAIKNDSL---RKEKK---------YIQEIKSITEINANFEKSVRL----NEKMIT 488
Query: 642 GGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELP 701
+ + L+++ + R + EK+ K ++++ +V+ L S TA +
Sbjct: 489 KTVARYSQQ--LNDLKAENARLNSELEKEKHN-KERLEA--EVESLHSSLATAINE---- 539
Query: 702 HSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKME 757
+ ++E+ +E D VS + + +S +L + KN ELLT ++ K
Sbjct: 540 ------YNEIVERKDLELVLWRADDVSRHEKMGSNIS--QLTD--KN--ELLTEQVHKAR 587
Query: 758 DKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLR 817
K N L+ +L ET++ + + +L + + + ++ N + + +
Sbjct: 588 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 647
Query: 818 RKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDG 877
EE+ R++ LE L+ E + +N + + L E+N ++++
Sbjct: 648 SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE- 706
Query: 878 ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSH-KNSMLQEEIAMLRLEIDTIKNQNQ 936
N+L K+K ++ ++K E +E+ + H K + E N+
Sbjct: 707 --YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETW 763
Query: 937 EKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEK 996
+KK F+ +EK+E+ +K L + IS N + +N L E
Sbjct: 764 TSKKKLFQVEIQPEEKHEEFRK--------LFELISLLNYTADQIRKKNRELE---EEAT 812
Query: 997 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL---QDKMNFDVS 1053
K+ LE + ++ T + ++++ F++ + + + L ++ ++ +
Sbjct: 813 GYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECV 872
Query: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGL----ERVQKDLSQTQCQMK 1109
NL +NE+L Q+L + E + + L E+ L L E+ +L + Q
Sbjct: 873 NLAKDNEVLHQELLSMRNVQEKCE-KLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKS 931
Query: 1110 EMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
E++++ E K+ + ++ KQ E++L QL +N KE T+ +++
Sbjct: 932 ELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTA----------SLKKKELTLKDVE 981
Query: 1169 DQFHAIVQKLQAESEKQSLLLEE 1191
+F K++ E+ + LEE
Sbjct: 982 CKF----SKMKTAYEEVTTELEE 1000
Score = 46.2 bits (108), Expect = 3e-04
Identities = 113/576 (19%), Positives = 226/576 (39%), Gaps = 75/576 (13%)
Query: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL-LEERNKELISECNHLKERQYQYEN 1212
H NK ++ HA ++ L E L + R + ++ LK + +
Sbjct: 246 HYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFL--LKNQANIHAV 303
Query: 1213 EKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1272
+ +R ++ +Q L+ + + + ++ ++S+ E L L IR Q+ E
Sbjct: 304 DNFKRTALILAVQHNLSSIVTL--LLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILE 361
Query: 1273 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332
+++ K L DN + + K +E K N ++ +EK++
Sbjct: 362 HKNKML------------KNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQER 409
Query: 1333 KKLMELKQSLECNLDQEMKK----NVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388
+ E KQ + + K N L+++I K L + N+ E + ++
Sbjct: 410 LQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIK---NDSLRKEKKYIQEI 466
Query: 1389 KT-----SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKK 1443
K+ + FE +++N+ +T + + L +N L EL
Sbjct: 467 KSITEINANFEKSVRLNEKM-----ITKTVARYSQQLNDLKAENARLNSEL--------- 512
Query: 1444 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQA 1503
EK + NK++LE EV +L S + + +Y + +E + + + + +V+
Sbjct: 513 -EKEKHNKERLEAEVESLHSSLAT------AINEYNEIVERKDLELVLWRADDVS----R 561
Query: 1504 QAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELEKYKQLYLE 1561
N+ Q + N + + R+K L+ +L + + + + KT QL L
Sbjct: 562 HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALRE--KTLALGSVQLDLR 619
Query: 1562 ELKVRKSLSSKL-----TKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLN 1616
+ + R ++ K ++ + + N+ L E+ + + L L R + + G+ N
Sbjct: 620 QAQHRIKEMKQMHPNGEAKESQSIGKQNS--LEERIRQQELENLLLERQLEDARKEGD-N 676
Query: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSME-NYLSKMQQELEKN------ITRELKEAAA 1669
+ +N EN R E NYL + + EK I RE +E
Sbjct: 677 KEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV 736
Query: 1670 E-LESGSIA-SPLGSTDESNLNQDLVWKASREYVQV 1703
+ L++ SI+ SPL T ++N + W + ++ QV
Sbjct: 737 DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQV 772
Score = 34.3 bits (77), Expect = 1.1
Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 15/179 (8%)
Query: 685 DDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKN 744
+DL E S +C + + N +L E L M +D + E +L LK
Sbjct: 858 NDLVAEKEAVSSECV--NLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK-T 914
Query: 745 HCELLTVKIKKMED-KVNVLQRELSETKEIKSQLEHQKVEWERELCSLR----------- 792
H E V++ K+++ K + +R + E ++++ ++ E+E++L L
Sbjct: 915 HMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKE 974
Query: 793 FSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNL 851
+L E K T YE++ +L +E + V+ + L + ++ + + L
Sbjct: 975 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKL 1033
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 395 bits (1016), Expect = e-109
Identities = 277/828 (33%), Positives = 454/828 (54%), Gaps = 102/828 (12%)
Query: 838 QTLEMELRTVKSNLNQVVQERNDAQRQLS-REQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Q LE + + +K++L RND Q + + N + ++ H K E ++
Sbjct: 358 QILEHKNKMLKNHL------RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQ 411
Query: 897 NSEN-----SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKE 951
SEN S S+ ++KD + N ML+++IAML+ E+ IKN + KEKK +++K + E
Sbjct: 412 RSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 471
Query: 952 KNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHS 1011
N + +K+++ NE+ +T+T+++Y+ +L+ L AENA LNS+LE EK
Sbjct: 472 INANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK--------------- 516
Query: 1012 RLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTES 1071
H++++ E L + A + + NEI+ ++
Sbjct: 517 ------HNKERLEAEVESLHSSLATA-----------------INEYNEIVERK------ 547
Query: 1072 KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK--- 1128
LE+ D R + +G ++SQ + + + ++ +VK N GK
Sbjct: 548 ---DLELVLWRADDVSRHEKMG-----SNISQLTDKNELLTEQVHKARVKFNTLKGKLRE 599
Query: 1129 -QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
++++ E+ L S + LRQ A ++ K + Q H + +++S +
Sbjct: 600 TRDALREKTLALGSVQLDLRQ--------AQHRIKEM----KQMHPNGEAKESQSIGKQN 647
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LEER ++ E N L ERQ + ++ + + +V + ++ + K+ + E + E+
Sbjct: 648 SLEERIRQQELE-NLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 706
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
Y LK+KL Q +E +R E++ DH + + L+ T
Sbjct: 707 YNY--------LKEKLLQCE---KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755
Query: 1308 QMDKIEEL--QKNLLNANLSEDEK-EQLKKLMELKQSLECNLDQEMKKNVELEREITGFK 1364
++ E +K L + +EK E+ +KL EL L DQ KKN ELE E TG+K
Sbjct: 756 HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815
Query: 1365 NLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLD 1424
L+MT LN + N +FS HGDL T Q +MDI KLK K +DL AE E S+C++L
Sbjct: 816 KCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 875
Query: 1425 TKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
N++L +ELLSM+ VQ+KCEKL+K+KK LE+EV+NL++H+E++MVELG++++YK E++E
Sbjct: 876 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 935
Query: 1485 RARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQ 1544
RA QEI EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+
Sbjct: 936 RAVQEI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAY 991
Query: 1545 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1604
E+ TELE++K+ + +K S+S KL K+++++A ++TKL EKQ+ + +TL TR
Sbjct: 992 EEVT-TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTR 1050
Query: 1605 PVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKM 1652
P E PCV NL NS++LNRK IP+ + I TSNP+ SNN +N+L+++
Sbjct: 1051 PEPELPCVENL-NSIELNRKYIPKTAIRIPTSNPQTSNN-CKNFLTEV 1096
Score = 207 bits (527), Expect = 7e-53
Identities = 99/185 (53%), Positives = 140/185 (75%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ PGY +RD +L KIH+AA G+ A+V++ L R L+ RD+ +RT LHLACA+G +
Sbjct: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+ R+CQ+++CD NRT LMKAV QEE CA +LLE GA+PN+ D++GNTALHYAV
Sbjct: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YN+ S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
Query: 215 HQLIS 219
+++
Sbjct: 310 ALILA 314
Score = 70.1 bits (170), Expect = 2e-11
Identities = 150/743 (20%), Positives = 305/743 (41%), Gaps = 94/743 (12%)
Query: 463 MSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAA 522
M G A D R++ + ++ HL+ + +++ K +K + A
Sbjct: 338 MFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKA 395
Query: 523 EHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGL 581
EH+L+VASEE+QER + SEN QPQ + K + D + D L
Sbjct: 396 EHNLKVASEEKQERLQRSENKQPQDSQSYGKKK-----------DAMYGNFMLKKDIAML 444
Query: 582 IQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLT 641
++ + + D RKE K ++E+KS + ++SV ++T
Sbjct: 445 KEELYAIKNDSL---RKEKK---------YIQEIKSITEINANFEKSVRL----NEKMIT 488
Query: 642 GGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELP 701
+ + L+++ + R + EK+ K ++++ +V+ L S TA +
Sbjct: 489 KTVARYSQQ--LNDLKAENARLNSELEKEKHN-KERLEA--EVESLHSSLATAINE---- 539
Query: 702 HSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKME 757
+ ++E+ +E D VS + + +S +L + KN ELLT ++ K
Sbjct: 540 ------YNEIVERKDLELVLWRADDVSRHEKMGSNIS--QLTD--KN--ELLTEQVHKAR 587
Query: 758 DKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLR 817
K N L+ +L ET++ + + +L + + + ++ N + + +
Sbjct: 588 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 647
Query: 818 RKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDG 877
EE+ R++ LE L+ E + +N + + L E+N ++++
Sbjct: 648 SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE- 706
Query: 878 ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSH-KNSMLQEEIAMLRLEIDTIKNQNQ 936
N+L K+K ++ ++K E +E+ + H K + E N+
Sbjct: 707 --YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETW 763
Query: 937 EKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEK 996
+KK F+ +EK+E+ +K L + IS N + +N L E
Sbjct: 764 TSKKKLFQVEIQPEEKHEEFRK--------LFELISLLNYTADQIRKKNRELE---EEAT 812
Query: 997 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL---QDKMNFDVS 1053
K+ LE + ++ T + ++++ F++ + + + L ++ ++ +
Sbjct: 813 GYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECV 872
Query: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGL----ERVQKDLSQTQCQMK 1109
NL +NE+L Q+L + E + + L E+ L L E+ +L + Q
Sbjct: 873 NLAKDNEVLHQELLSMRNVQEKCE-KLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKS 931
Query: 1110 EMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
E++++ E K+ + ++ KQ E++L QL +N KE T+ +++
Sbjct: 932 ELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTA----------SLKKKELTLKDVE 981
Query: 1169 DQFHAIVQKLQAESEKQSLLLEE 1191
+F K++ E+ + LEE
Sbjct: 982 CKF----SKMKTAYEEVTTELEE 1000
Score = 46.2 bits (108), Expect = 3e-04
Identities = 113/576 (19%), Positives = 226/576 (39%), Gaps = 75/576 (13%)
Query: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL-LEERNKELISECNHLKERQYQYEN 1212
H NK ++ HA ++ L E L + R + ++ LK + +
Sbjct: 246 HYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFL--LKNQANIHAV 303
Query: 1213 EKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1272
+ +R ++ +Q L+ + + + ++ ++S+ E L L IR Q+ E
Sbjct: 304 DNFKRTALILAVQHNLSSIVTL--LLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILE 361
Query: 1273 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332
+++ K L DN + + K +E K N ++ +EK++
Sbjct: 362 HKNKML------------KNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQER 409
Query: 1333 KKLMELKQSLECNLDQEMKK----NVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388
+ E KQ + + K N L+++I K L + N+ E + ++
Sbjct: 410 LQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIK---NDSLRKEKKYIQEI 466
Query: 1389 KT-----SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKK 1443
K+ + FE +++N+ +T + + L +N L EL
Sbjct: 467 KSITEINANFEKSVRLNEKM-----ITKTVARYSQQLNDLKAENARLNSEL--------- 512
Query: 1444 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQA 1503
EK + NK++LE EV +L S + + +Y + +E + + + + +V+
Sbjct: 513 -EKEKHNKERLEAEVESLHSSLAT------AINEYNEIVERKDLELVLWRADDVS----R 561
Query: 1504 QAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELEKYKQLYLE 1561
N+ Q + N + + R+K L+ +L + + + + KT QL L
Sbjct: 562 HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALRE--KTLALGSVQLDLR 619
Query: 1562 ELKVRKSLSSKL-----TKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLN 1616
+ + R ++ K ++ + + N+ L E+ + + L L R + + G+ N
Sbjct: 620 QAQHRIKEMKQMHPNGEAKESQSIGKQNS--LEERIRQQELENLLLERQLEDARKEGD-N 676
Query: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSME-NYLSKMQQELEKN------ITRELKEAAA 1669
+ +N EN R E NYL + + EK I RE +E
Sbjct: 677 KEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV 736
Query: 1670 E-LESGSIA-SPLGSTDESNLNQDLVWKASREYVQV 1703
+ L++ SI+ SPL T ++N + W + ++ QV
Sbjct: 737 DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQV 772
Score = 34.3 bits (77), Expect = 1.1
Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 15/179 (8%)
Query: 685 DDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKN 744
+DL E S +C + + N +L E L M +D + E +L LK
Sbjct: 858 NDLVAEKEAVSSECV--NLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK-T 914
Query: 745 HCELLTVKIKKMED-KVNVLQRELSETKEIKSQLEHQKVEWERELCSLR----------- 792
H E V++ K+++ K + +R + E ++++ ++ E+E++L L
Sbjct: 915 HMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKE 974
Query: 793 FSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNL 851
+L E K T YE++ +L +E + V+ + L + ++ + + L
Sbjct: 975 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKL 1033
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 389 bits (1000), Expect = e-107
Identities = 273/819 (33%), Positives = 446/819 (54%), Gaps = 101/819 (12%)
Query: 838 QTLEMELRTVKSNLNQVVQERNDAQRQLS-REQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Q LE + + +K++L RND Q + + N + ++ H K E ++
Sbjct: 251 QILEHKNKMLKNHL------RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQ 304
Query: 897 NSEN-----SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKE 951
SEN S S+ ++KD + N ML+++IAML+ E+ IKN + KEKK +++K + E
Sbjct: 305 RSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 364
Query: 952 KNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHS 1011
N + +K+++ NE+ +T+T+++Y+ +L+ L AENA LNS+LE EK
Sbjct: 365 INANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK--------------- 409
Query: 1012 RLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTES 1071
H++++ E L + A + + NEI+ ++
Sbjct: 410 ------HNKERLEAEVESLHSSLATA-----------------INEYNEIVERK------ 440
Query: 1072 KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK--- 1128
LE+ D R + +G ++SQ + + + ++ +VK N GK
Sbjct: 441 ---DLELVLWRADDVSRHEKMG-----SNISQLTDKNELLTEQVHKARVKFNTLKGKLRE 492
Query: 1129 -QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 1187
++++ E+ L S + LRQ A ++ K + Q H + +++S +
Sbjct: 493 TRDALREKTLALGSVQLDLRQ--------AQHRIKEM----KQMHPNGEAKESQSIGKQN 540
Query: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
LEER ++ E N L ERQ + ++ + + +V + ++ + K+ + E + E+
Sbjct: 541 SLEERIRQQELE-NLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 599
Query: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
Y LK+KL Q +E +R E++ DH + + L+ T
Sbjct: 600 YNY--------LKEKLLQCE---KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 648
Query: 1308 QMDKIEEL--QKNLLNANLSEDEK-EQLKKLMELKQSLECNLDQEMKKNVELEREITGFK 1364
++ E +K L + +EK E+ +KL EL L DQ KKN ELE E TG+K
Sbjct: 649 HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 708
Query: 1365 NLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLD 1424
L+MT LN + N +FS HGDL T Q +MDI KLK K +DL AE E S+C++L
Sbjct: 709 KCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 768
Query: 1425 TKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
N++L +ELLSM+ VQ+KCEKL+K+KK LE+EV+NL++H+E++MVELG++++YK E++E
Sbjct: 769 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDE 828
Query: 1485 RARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQ 1544
RA QEI EKL+E++ LQ QA ++ LEQ ++N AS+K + EL +KD+E + SK+KT+
Sbjct: 829 RAVQEI-EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAY 884
Query: 1545 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1604
E+ TELE++K+ + +K S+S KL K+++++A ++TKL +EK++ +TL R
Sbjct: 885 EEVT-TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFMEKERMEYFLSTLPMR 943
Query: 1605 PVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNN 1643
P E PCV NL NS++LNRK IP+ + I TSNP+ SNN
Sbjct: 944 PDPELPCVENL-NSIELNRKYIPKMAIRIPTSNPQTSNN 981
Score = 207 bits (527), Expect = 7e-53
Identities = 99/185 (53%), Positives = 140/185 (75%)
Query: 35 YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94
Y+ PGY +RD +L KIH+AA G+ A+V++ L R L+ RD+ +RT LHLACA+G +
Sbjct: 23 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 82
Query: 95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
VVTLL+ R+CQ+++CD NRT LMKAV QEE CA +LLE GA+PN+ D++GNTALHYAV
Sbjct: 83 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 142
Query: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
YN+ S+A +LL + ANIEA NK+ TPLL A++ ++Q MVEFL+K +AN++AVD + +
Sbjct: 143 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 202
Query: 215 HQLIS 219
+++
Sbjct: 203 ALILA 207
Score = 70.1 bits (170), Expect = 2e-11
Identities = 150/743 (20%), Positives = 305/743 (41%), Gaps = 94/743 (12%)
Query: 463 MSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAA 522
M G A D R++ + ++ HL+ + +++ K +K + A
Sbjct: 231 MFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKA 288
Query: 523 EHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGL 581
EH+L+VASEE+QER + SEN QPQ + K + D + D L
Sbjct: 289 EHNLKVASEEKQERLQRSENKQPQDSQSYGKKK-----------DAMYGNFMLKKDIAML 337
Query: 582 IQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLT 641
++ + + D RKE K ++E+KS + ++SV ++T
Sbjct: 338 KEELYAIKNDSL---RKEKK---------YIQEIKSITEINANFEKSVRL----NEKMIT 381
Query: 642 GGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELP 701
+ + L+++ + R + EK+ K ++++ +V+ L S TA +
Sbjct: 382 KTVARYSQQ--LNDLKAENARLNSELEKEKHN-KERLEA--EVESLHSSLATAINE---- 432
Query: 702 HSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKME 757
+ ++E+ +E D VS + + +S +L + KN ELLT ++ K
Sbjct: 433 ------YNEIVERKDLELVLWRADDVSRHEKMGSNIS--QLTD--KN--ELLTEQVHKAR 480
Query: 758 DKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLR 817
K N L+ +L ET++ + + +L + + + ++ N + + +
Sbjct: 481 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 540
Query: 818 RKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDG 877
EE+ R++ LE L+ E + +N + + L E+N ++++
Sbjct: 541 SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE- 599
Query: 878 ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSH-KNSMLQEEIAMLRLEIDTIKNQNQ 936
N+L K+K ++ ++K E +E+ + H K + E N+
Sbjct: 600 --YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETW 656
Query: 937 EKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEK 996
+KK F+ +EK+E+ +K L + IS N + +N L E
Sbjct: 657 TSKKKLFQVEIQPEEKHEEFRK--------LFELISLLNYTADQIRKKNRELE---EEAT 705
Query: 997 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL---QDKMNFDVS 1053
K+ LE + ++ T + ++++ F++ + + + L ++ ++ +
Sbjct: 706 GYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECV 765
Query: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGL----ERVQKDLSQTQCQMK 1109
NL +NE+L Q+L + E + + L E+ L L E+ +L + Q
Sbjct: 766 NLAKDNEVLHQELLSMRNVQEKCE-KLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKS 824
Query: 1110 EMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
E++++ E K+ + ++ KQ E++L QL +N KE T+ +++
Sbjct: 825 ELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTA----------SLKKKELTLKDVE 874
Query: 1169 DQFHAIVQKLQAESEKQSLLLEE 1191
+F K++ E+ + LEE
Sbjct: 875 CKF----SKMKTAYEEVTTELEE 893
Score = 46.2 bits (108), Expect = 3e-04
Identities = 113/576 (19%), Positives = 226/576 (39%), Gaps = 75/576 (13%)
Query: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL-LEERNKELISECNHLKERQYQYEN 1212
H NK ++ HA ++ L E L + R + ++ LK + +
Sbjct: 139 HYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFL--LKNQANIHAV 196
Query: 1213 EKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1272
+ +R ++ +Q L+ + + + ++ ++S+ E L L IR Q+ E
Sbjct: 197 DNFKRTALILAVQHNLSSIVTL--LLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILE 254
Query: 1273 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332
+++ K L DN + + K +E K N ++ +EK++
Sbjct: 255 HKNKML------------KNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQER 302
Query: 1333 KKLMELKQSLECNLDQEMKK----NVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388
+ E KQ + + K N L+++I K L + N+ E + ++
Sbjct: 303 LQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIK---NDSLRKEKKYIQEI 359
Query: 1389 KT-----SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKK 1443
K+ + FE +++N+ +T + + L +N L EL
Sbjct: 360 KSITEINANFEKSVRLNEKM-----ITKTVARYSQQLNDLKAENARLNSEL--------- 405
Query: 1444 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQA 1503
EK + NK++LE EV +L S + + +Y + +E + + + + +V+
Sbjct: 406 -EKEKHNKERLEAEVESLHSSLAT------AINEYNEIVERKDLELVLWRADDVS----R 454
Query: 1504 QAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELEKYKQLYLE 1561
N+ Q + N + + R+K L+ +L + + + + KT QL L
Sbjct: 455 HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALRE--KTLALGSVQLDLR 512
Query: 1562 ELKVRKSLSSKL-----TKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLN 1616
+ + R ++ K ++ + + N+ L E+ + + L L R + + G+ N
Sbjct: 513 QAQHRIKEMKQMHPNGEAKESQSIGKQNS--LEERIRQQELENLLLERQLEDARKEGD-N 569
Query: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSME-NYLSKMQQELEKN------ITRELKEAAA 1669
+ +N EN R E NYL + + EK I RE +E
Sbjct: 570 KEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV 629
Query: 1670 E-LESGSIA-SPLGSTDESNLNQDLVWKASREYVQV 1703
+ L++ SI+ SPL T ++N + W + ++ QV
Sbjct: 630 DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQV 665
Score = 34.3 bits (77), Expect = 1.1
Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 15/179 (8%)
Query: 685 DDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKN 744
+DL E S +C + + N +L E L M +D + E +L LK
Sbjct: 751 NDLVAEKEAVSSECV--NLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK-T 807
Query: 745 HCELLTVKIKKMED-KVNVLQRELSETKEIKSQLEHQKVEWERELCSLR----------- 792
H E V++ K+++ K + +R + E ++++ ++ E+E++L L
Sbjct: 808 HMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKE 867
Query: 793 FSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNL 851
+L E K T YE++ +L +E + V+ + L + ++ + + L
Sbjct: 868 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKL 926
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sapiens]
Length = 823
Score = 303 bits (777), Expect = 7e-82
Identities = 186/447 (41%), Positives = 264/447 (59%), Gaps = 68/447 (15%)
Query: 780 QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839
+K++ E + C+L+ QE E++ N + LY+K RE+L RKE
Sbjct: 431 KKLKEEHDRCTLK----QENEEKTNVNMLYKKNREELERKE------------------- 467
Query: 840 LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNS- 898
+Q +E A+ L+ + + +EM K +
Sbjct: 468 -----------------------KQYKKEVEAKQLEPTV--------QSLEMKSKTARNT 496
Query: 899 --ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDL 956
+ H+HEE K L +N +L+ +IA+LR EI T+KN N EKE K +D+KIVKE N L
Sbjct: 497 PNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAAL 556
Query: 957 QKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1016
+K IK NEE +T+T +Y L+ L AEN LN++L EK+SK+RLEA++ESY SRLAAA
Sbjct: 557 EKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
Query: 1017 IHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSL 1076
I +S ++R L+LA +R RD +Q +M+ +S +KD NE L++QL +T+ K N+L
Sbjct: 617 ISKHSESVKTERNLKLALERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNAL 674
Query: 1077 EIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1136
+ +F TRD+LR+K+L LE VQ DLSQTQ Q +EM++ YQN + KVN GK VEER+
Sbjct: 675 KDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
Query: 1137 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL 1196
LQ EN L QQLDD H K D+KE V NIQ F ES K+ L+LEE++K+L
Sbjct: 735 CHLQRENAWLVQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKL 785
Query: 1197 ISECNHLKERQYQYENEKAEREVVVRQ 1223
++EC+HLKE +QYE EK E V +++
Sbjct: 786 MNECDHLKESLFQYEREKTEGVVSIKE 812
Score = 230 bits (586), Expect = 1e-59
Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 44/308 (14%)
Query: 28 GEPGEGA----YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTA 83
G+ +G+ Y+ GY +RD +L KIH+AA G+ A+V++ L R L+ DK +RTA
Sbjct: 11 GQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTA 70
Query: 84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLAD 143
LHLACA+GH +VVTLLV+RKCQ++VCD ENRT L++AV CQEE CA ILLEHGA+PNL D
Sbjct: 71 LHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKD 130
Query: 144 VHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
++GNTALHYAVY+E S+A KLL + A+IEA +KD+ TPLL A+ KK++MVEFL+K+KA
Sbjct: 131 IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKA 190
Query: 204 NVNAVDKLESSHQLISEY---------------------------KEERIPKHSSQNSNS 236
+ +AVD+L S +++ Y ++ I H ++
Sbjct: 191 SSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQ 250
Query: 237 VDESSEDSLSRLSGKPGVD-------------DSWPTSDDEDLNFDTKNVPKPSLAKLMT 283
+ E + L + G DS P SDD+DLN TK +++ +
Sbjct: 251 ILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLP 310
Query: 284 ASQQSRKN 291
S + N
Sbjct: 311 GSSHEKGN 318
Score = 107 bits (266), Expect = 1e-22
Identities = 152/666 (22%), Positives = 280/666 (42%), Gaps = 111/666 (16%)
Query: 412 QEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKM 471
++ D+ S ES F + VD L A+D K+ N+ +Q + + GS + K
Sbjct: 262 EKSDVGS--SDESAVSIFHELRVDSLP-ASDDKDLNVATKQCVPE-KVSEPLPGSSHEKG 317
Query: 472 AKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASE 531
++ + + G P H LKP+ E++D A K+VQT +A E L VASE
Sbjct: 318 NRIVNGQGEGPPAKHPS-------LKPSTEVEDPAVKGAVQRKNVQTLRA-EQALPVASE 369
Query: 532 EEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 590
EEQER E SE QPQV+E +++ ++++S NI D + A L Q+RK G+T
Sbjct: 370 EEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAA-----GRLTQQRKIGKT 424
Query: 591 DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 650
QQFP+K +E+ + T K++ K +VN ++ K
Sbjct: 425 YPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM-LYKK-------------- 458
Query: 651 SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 710
+ E++ E + K+ E +++ +QS++ S+TA P+ + N
Sbjct: 459 -NREELERKEKQYKKEV--EAKQLEPTVQSLE------MKSKTAR---NTPNRDFHNHE- 505
Query: 711 LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 770
E G+ D +LK D A+ + + +K ++ E K N +++
Sbjct: 506 --EMKGL--MDENCILK-ADIAILRQEICTMKNDNLE-----------KENKYLKDIKIV 549
Query: 771 KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 830
KE + LE E + F QE ++ + R + KE E K
Sbjct: 550 KETNAALEKYIKLNEEMITETAFRYQQE----------LNYLKAENTRLNAELLKEKESK 599
Query: 831 QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIE 890
++LE +++ + L S ++ V+ + + L R T +S Q E+
Sbjct: 600 KRLEADIESYQSRLAAAISKHSESVKTERNLKLALER------------TRDVSVQVEMS 647
Query: 891 MAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVK 950
A K+ EN E+ + K + L+++ R D+++ ++ E DL +
Sbjct: 648 SAISKVKDENEFLTEQLSETQIKFNALKDKFRKTR---DSLRKKSLALE-TVQNDLSQTQ 703
Query: 951 EKNEDLQKTIKQNEETLTQTISQYN---GRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
++ +++++ + E + + ++N R+ L ENA L +L++ Q ++ E
Sbjct: 704 QQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTN 763
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKM-NFDVSNLKDNNEILSQQL 1066
+ + D E SK+ + +EC L++ + ++ + I +
Sbjct: 764 IQRGFIESGKKDLVLEEKSKKLM--------NECDHLKESLFQYEREKTEGVVSIKEDKY 815
Query: 1067 FKTESK 1072
F+T K
Sbjct: 816 FQTSRK 821
Score = 49.3 bits (116), Expect = 3e-05
Identities = 100/480 (20%), Positives = 192/480 (40%), Gaps = 47/480 (9%)
Query: 1097 VQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNK 1156
VQ+ QT + + + EQ + + KQ V+E + +SE + L + + D+ +
Sbjct: 350 VQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSS 409
Query: 1157 A-----DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYE 1211
A + K QF +KL+ E ++ +L E K ++ + + +
Sbjct: 410 AAAGRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK 466
Query: 1212 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQ 1271
++ ++EV +QL+ T++ M + T + +E + L + N +
Sbjct: 467 EKQYKKEVEAKQLE----PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDE-----NCIL 517
Query: 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQMDKIEELQKNLLNANLSEDE-- 1328
+A C K LEK+N LK + + K+ + E L ++E
Sbjct: 518 KADIAILRQEICTMK----NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR 573
Query: 1329 -KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGD 1387
+++L L L L +E + LE +I +++ L K +E E +
Sbjct: 574 YQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLA 633
Query: 1388 LKTS-----QFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK----NQILQEELLSMK 1438
L+ + Q EM I+K+K + + LT +L K L K L+++ L+++
Sbjct: 634 LERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALE 693
Query: 1439 TVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVN 1498
TVQ + Q+ +++++ N + + + + V EER L+ N
Sbjct: 694 TVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCV-------EERICH-----LQREN 741
Query: 1499 LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE-SELSKIKTSQEDFNKTELEKYKQ 1557
+L Q E +E + +E KDL E SK ++ D K L +Y++
Sbjct: 742 AWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYER 801
Score = 43.9 bits (102), Expect = 0.001
Identities = 78/432 (18%), Positives = 172/432 (39%), Gaps = 72/432 (16%)
Query: 1105 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTV 1164
+C +K+ ++ N + K +E +E + Q + E + +QL+ + K KT
Sbjct: 439 RCTLKQENEEKTNVNMLYKK---NREELERKEKQYKKE--VEAKQLEPTVQSLEMKSKTA 493
Query: 1165 INIQDQFHAIVQKLQAESEKQSLLLEE-----------RNKELISECNHLKERQYQYENE 1213
N ++ ++++ ++ +L + +N L E +LK+ + E
Sbjct: 494 RNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETN 553
Query: 1214 KAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE-----DETQDLKKKLGQIRN 1268
A + + +L +E+ + E + R+N E + + L+ + ++
Sbjct: 554 AALEKYI--KLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQS 611
Query: 1269 QLQEAQDRHTEAVRCAEKMQDHKQKLEKD-NAKLKVTVKKQMDKIEELQKNLLNANLSED 1327
+L A +H+E+V+ + K LE+ + ++V + + K+++ N L+E
Sbjct: 612 RLAAAISKHSESVKTERNL---KLALERTRDVSVQVEMSSAISKVKDE-----NEFLTEQ 663
Query: 1328 EKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGD 1387
E K LK D KK++ LE + T++ Y+N E
Sbjct: 664 LSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------ 717
Query: 1388 LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKL 1447
K+++ T + + HL +N L ++L +
Sbjct: 718 ----------------AKVNNSTGKWNCVEERICHLQRENAWLVQQLDDV---------- 751
Query: 1448 QKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAAS 1507
++K+ +E++ ++I+R +E G+ +E ++ E + LKE +LF Q +
Sbjct: 752 --HQKEDHKEIV---TNIQRGFIESGKKDLVLEEKSKKLMNE-CDHLKE-SLF-QYEREK 803
Query: 1508 QENLEQFRENNF 1519
E + +E+ +
Sbjct: 804 TEGVVSIKEDKY 815
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sapiens]
Length = 823
Score = 303 bits (775), Expect = 1e-81
Identities = 186/447 (41%), Positives = 264/447 (59%), Gaps = 68/447 (15%)
Query: 780 QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839
+K++ E + C+L+ QE E++ N + LY+K RE+L RKE
Sbjct: 431 KKLKEEHDRCTLK----QENEEKTNVNMLYKKNREELERKE------------------- 467
Query: 840 LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNS- 898
+Q +E A+ L+ + + +EM K +
Sbjct: 468 -----------------------KQYKKEVEAKQLEPTV--------QSLEMKSKTARNT 496
Query: 899 --ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDL 956
+ H+HEE K L +N +L+ +IA+LR EI T+KN N EKE K +D+KIVKE N L
Sbjct: 497 PNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAAL 556
Query: 957 QKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1016
+K IK NEE +T+T +Y L+ L AEN LN++L EK+SK+RLEA++ESY SRLAAA
Sbjct: 557 EKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
Query: 1017 IHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSL 1076
I +S ++R L+LA +R RD +Q +M+ +S +KD NE L++QL +T+ K N+L
Sbjct: 617 ISKHSESVKTERNLKLALERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNAL 674
Query: 1077 EIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1136
+ +F TRD+LR+K+L LE VQ DLSQTQ Q +EM++ YQN + KVN GK VEER+
Sbjct: 675 KDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
Query: 1137 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL 1196
LQ EN L QQLDD H K D+KE V NIQ F ES K+ L+LEE++K+L
Sbjct: 735 CHLQRENAWLVQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKL 785
Query: 1197 ISECNHLKERQYQYENEKAEREVVVRQ 1223
++EC+HLKE +QYE EK E V +++
Sbjct: 786 MNECDHLKESLFQYEREKTEGVVSIKE 812
Score = 230 bits (586), Expect = 1e-59
Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 44/308 (14%)
Query: 28 GEPGEGA----YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTA 83
G+ +G+ Y+ GY +RD +L KIH+AA G+ A+V++ L R L+ DK +RTA
Sbjct: 11 GQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTA 70
Query: 84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLAD 143
LHLACA+GH +VVTLLV+RKCQ++VCD ENRT L++AV CQEE CA ILLEHGA+PNL D
Sbjct: 71 LHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKD 130
Query: 144 VHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
++GNTALHYAVY+E S+A KLL + A+IEA +KD+ TPLL A+ KK++MVEFL+K+KA
Sbjct: 131 IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKA 190
Query: 204 NVNAVDKLESSHQLISEY---------------------------KEERIPKHSSQNSNS 236
+ +AVD+L S +++ Y ++ I H ++
Sbjct: 191 SSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQ 250
Query: 237 VDESSEDSLSRLSGKPGVD-------------DSWPTSDDEDLNFDTKNVPKPSLAKLMT 283
+ E + L + G DS P SDD+DLN TK +++ +
Sbjct: 251 ILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLP 310
Query: 284 ASQQSRKN 291
S + N
Sbjct: 311 GSSHEKGN 318
Score = 107 bits (267), Expect = 1e-22
Identities = 152/666 (22%), Positives = 280/666 (42%), Gaps = 111/666 (16%)
Query: 412 QEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKM 471
++ D+ S ES F + VD L A+D K+ N+ +Q + + GS + K
Sbjct: 262 EKSDVGS--SDESAVSIFHELRVDSLP-ASDDKDLNVATKQCVPE-KVSEPLPGSSHEKG 317
Query: 472 AKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASE 531
++ + + G P H LKP+ E++D A K+VQT +A E L VASE
Sbjct: 318 NRIVNGQGEGPPAKHPS-------LKPSTEVEDPAVKGAVQRKNVQTLRA-EQALPVASE 369
Query: 532 EEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 590
EEQER E SE QPQV+E +++ ++++S NI D + A L Q+RK G+T
Sbjct: 370 EEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAA-----GRLTQQRKIGKT 424
Query: 591 DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 650
QQFP+K +E+ + T K++ K +VN ++ K
Sbjct: 425 YPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM-LYKK-------------- 458
Query: 651 SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 710
+ E++ E + K+ E +++ +QS++ S+TA P+ + N
Sbjct: 459 -NREELERKEKQYKKEV--EAKQLEPTVQSLE------MKSKTAR---NTPNRDFHNHE- 505
Query: 711 LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 770
E G+ D +LK D A+ + + +K ++ E K N +++
Sbjct: 506 --EMKGL--MDENCILK-ADIAILRQEICTMKNDNLE-----------KENKYLKDIKIV 549
Query: 771 KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 830
KE + LE E + F QE ++ + R + KE E K
Sbjct: 550 KETNAALEKYIKLNEEMITETAFRYQQE----------LNDLKAENTRLNAELLKEKESK 599
Query: 831 QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIE 890
++LE +++ + L S ++ V+ + + L R T +S Q E+
Sbjct: 600 KRLEADIESYQSRLAAAISKHSESVKTERNLKLALER------------TRDVSVQVEMS 647
Query: 891 MAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVK 950
A K+ EN E+ + K + L+++ R D+++ ++ E DL +
Sbjct: 648 SAISKVKDENEFLTEQLSETQIKFNALKDKFRKTR---DSLRKKSLALE-TVQNDLSQTQ 703
Query: 951 EKNEDLQKTIKQNEETLTQTISQYN---GRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
++ +++++ + E + + ++N R+ L ENA L +L++ Q ++ E
Sbjct: 704 QQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTN 763
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKM-NFDVSNLKDNNEILSQQL 1066
+ + D E SK+ + +EC L++ + ++ + I +
Sbjct: 764 IQRGFIESGKKDLVLEEKSKKLM--------NECDHLKESLFQYEREKTEGVVSIKEDKY 815
Query: 1067 FKTESK 1072
F+T K
Sbjct: 816 FQTSRK 821
Score = 50.8 bits (120), Expect = 1e-05
Identities = 101/480 (21%), Positives = 193/480 (40%), Gaps = 47/480 (9%)
Query: 1097 VQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNK 1156
VQ+ QT + + + EQ + + KQ V+E + +SE + L + + D+ +
Sbjct: 350 VQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSS 409
Query: 1157 A-----DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYE 1211
A + K QF +KL+ E ++ +L E K ++ + + +
Sbjct: 410 AAAGRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK 466
Query: 1212 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQ 1271
++ ++EV +QL+ T++ M + T + +E + L + N +
Sbjct: 467 EKQYKKEVEAKQLE----PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDE-----NCIL 517
Query: 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQMDKIEELQKNLLNANLSEDEKE 1330
+A C K LEK+N LK + + K+ + E L ++E
Sbjct: 518 KADIAILRQEICTMK----NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR 573
Query: 1331 QLKKLMELKQS---LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGD 1387
++L +LK L L +E + LE +I +++ L K +E E +
Sbjct: 574 YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLA 633
Query: 1388 LKTS-----QFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK----NQILQEELLSMK 1438
L+ + Q EM I+K+K + + LT +L K L K L+++ L+++
Sbjct: 634 LERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALE 693
Query: 1439 TVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVN 1498
TVQ + Q+ +++++ N + + + + V EER L+ N
Sbjct: 694 TVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCV-------EERICH-----LQREN 741
Query: 1499 LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE-SELSKIKTSQEDFNKTELEKYKQ 1557
+L Q E +E + +E KDL E SK ++ D K L +Y++
Sbjct: 742 AWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYER 801
Score = 44.7 bits (104), Expect = 8e-04
Identities = 88/456 (19%), Positives = 184/456 (40%), Gaps = 89/456 (19%)
Query: 1068 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 1127
+ E K N + + + R+ L K ++ + + Q + ++ +E K + + N+
Sbjct: 445 ENEEKTN-VNMLYKKNREELERKEKQYKK-EVEAKQLEPTVQSLEMKSKTARNTPNRDFH 502
Query: 1128 KQESVEERLSQ---LQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1184
E ++ + + L+++ +LRQ++ N DN EK ++D IV++ A EK
Sbjct: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLEKENKYLKDI--KIVKETNAALEK 558
Query: 1185 QSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV 1244
L N+E+I+E ++Y+ E + + +L EL + + EA +E
Sbjct: 559 YIKL----NEEMITET------AFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIE- 607
Query: 1245 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD-NAKLKV 1303
+++L A +H+E+V+ + K LE+ + ++V
Sbjct: 608 --------------------SYQSRLAAAISKHSESVKTERNL---KLALERTRDVSVQV 644
Query: 1304 TVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF 1363
+ + K+++ N L+E E K LK D KK++ LE
Sbjct: 645 EMSSAISKVKDE-----NEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
Query: 1364 KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL 1423
+ T++ Y+N E K+++ T + + HL
Sbjct: 700 SQTQQQTQEMKEMYQNAE----------------------AKVNNSTGKWNCVEERICHL 737
Query: 1424 DTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1483
+N L ++L + ++K+ +E++ ++I+R +E G+ +E
Sbjct: 738 QRENAWLVQQLDDV------------HQKEDHKEIV---TNIQRGFIESGKKDLVLEEKS 782
Query: 1484 ERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNF 1519
++ E + LKE +LF Q + E + +E+ +
Sbjct: 783 KKLMNE-CDHLKE-SLF-QYEREKTEGVVSIKEDKY 815
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 300 bits (769), Expect = 6e-81
Identities = 189/470 (40%), Positives = 281/470 (59%), Gaps = 41/470 (8%)
Query: 764 QRELSETK-----EIKSQLEHQKVEWERELCSLRFSLNQEE--EKRRNADTLYEKIREQL 816
+RE SE K E + + +K++ +C FS + ++R+ T ++ ++L
Sbjct: 374 RRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKL 433
Query: 817 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQD 876
KEE R ++ + + + ++ L + R +E ++Q +E A+ L+
Sbjct: 434 --KEEHDRCTLKQENEEKTNVNMLHKKNR----------EELERKEKQYKKEVEAKQLEP 481
Query: 877 GILTNHLSKQKEIEMAQKKMNS---ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN 933
+ + +EM K + ++ H+HEE KDL +N +L+ +IA+LR EI T+KN
Sbjct: 482 TV--------QSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKN 533
Query: 934 QNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 993
N EKE K +D+KI KE N L+K IK NEE +T+T Y L+ L AEN LNS+L
Sbjct: 534 DNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELL 593
Query: 994 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVS 1053
EK+SK++LEAE+ESY SRLAAAI ++ ++R L+LA +R +D Q KM+ D+S
Sbjct: 594 KEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISE--QVKMSSDIS 651
Query: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQ 1113
++D N L++QL K + K N+L+ +F TRD LR+K+L LE VQ DLSQTQ Q+KEM++
Sbjct: 652 EIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE 711
Query: 1114 KYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHA 1173
YQ+ + KV+K GK VEER+ QLQ EN L QQL D H K D+KE VINIQ F
Sbjct: 712 MYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF-- 768
Query: 1174 IVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223
ES K+ L+LEE+NK+L++E +HLKE +QYE +KAE V +++
Sbjct: 769 ------IESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
Score = 215 bits (547), Expect = 3e-55
Identities = 110/214 (51%), Positives = 151/214 (70%), Gaps = 15/214 (7%)
Query: 6 SKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQI 65
S++G++ LGS + Y+ GY +R +L KIHKAA G+ A++++
Sbjct: 8 SRRGQTVLGSI---------------DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERC 52
Query: 66 LLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQE 125
L R L+ DK +RTALHLACA+GH +VVTLLV+RKCQ+++ D ENRT L++AV CQE
Sbjct: 53 LARRSGDLDALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQE 112
Query: 126 EKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLL 185
E CA ILLEHGA+PNL D++GNTALHYAVY+E S+A KLL + NIEA +KD TPLL
Sbjct: 113 EACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLF 172
Query: 186 AVSGKKQQMVEFLIKKKANVNAVDKLESSHQLIS 219
A+ KK++MVEFL+K KA+ +AVD+L + +++
Sbjct: 173 AIICKKEKMVEFLLKNKASTHAVDRLRXTALMLA 206
Score = 93.6 bits (231), Expect = 1e-18
Identities = 151/672 (22%), Positives = 264/672 (39%), Gaps = 123/672 (18%)
Query: 375 DIIESAPLEQTNNDNLTYVDEVHKNNRSDM----MSALGLGQEEDIES--PWDSESIS-- 426
D S L + L + + KN++ D+ SA+ + E ++S D E +S
Sbjct: 237 DYAISCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVA 296
Query: 427 --ENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPV 484
+ P+K +PL G + GK I N + E G P
Sbjct: 297 AKQCVPEKVSEPLRGPSHGKGNRIVNGKGE--------------------------GPPA 330
Query: 485 AHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQ 543
H LKP+ EM+D A K+VQT +A E L VASEEEQ+R E SE Q
Sbjct: 331 KHPS-------LKPSTEMEDPAVKGAVQXKNVQTLRA-EQALPVASEEEQQRRERSEKKQ 382
Query: 544 PQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEY 603
PQV E +++ ++++S NI A D L Q+RK G+T QQFP+K +E+
Sbjct: 383 PQVIEGNNTYKSEKIQLSENICHSTFSAAA-----DRLTQQRKIGKTYPQQFPKKLKEEH 437
Query: 604 ASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRP 663
+ T K++ K +VN + + E++ E +
Sbjct: 438 D-----------RCTLKQENEEKTNVN----------------MLHKKNREELERKEKQY 470
Query: 664 TKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSV 723
K+ E +++ +QS++ ++ T ++D H K+ M D
Sbjct: 471 KKEV--EAKQLEPTVQSLEMKPKTARN--TPNQDFH-NHEEVKDLM-----------DEN 514
Query: 724 SLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVE 783
+LK D A+ + + +K ++ E K N +++ KE + LE
Sbjct: 515 CILK-TDIAILRQEICTMKNDNLE-----------KENKYLKDIKIAKETNAALEKCIKL 562
Query: 784 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 843
E + F QE + +T E L+ KE + + E E++ +
Sbjct: 563 NEEMITKTAFWYQQELNDLKAENTRLNS--ELLKEKESKKKLEAEIESYQSRLAAAISKH 620
Query: 844 LRTVKS--NLNQVVQERNDAQRQLSREQNARMLQD--GILTNHLSKQKEIEMAQKKMNSE 899
VK+ NL ++ D Q+ + ++D LT LSK Q K N+
Sbjct: 621 SENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM------QIKFNTL 674
Query: 900 NSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCFEDL---KIVKEKN 953
+ L K+ L Q +++ + +I +K Q E K + V+E+
Sbjct: 675 KDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
Query: 954 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRL 1013
LQ+ E+ L + + + V+ + + S+ ++ ++ + E H +
Sbjct: 735 CQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
Query: 1014 AAAIHDRDQSET 1025
+ ++R ++ET
Sbjct: 795 SLFQYERQKAET 806
Score = 57.4 bits (137), Expect = 1e-07
Identities = 103/501 (20%), Positives = 205/501 (40%), Gaps = 55/501 (10%)
Query: 1075 SLEIEFHHTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQVKVNKYIGKQES 1131
S E+E + A++ K + R ++ L S+ + Q +E +K Q + ++ N K E
Sbjct: 338 STEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQVIEGNNTY-KSEK 396
Query: 1132 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191
++ SEN + A ++ + K QF +KL+ E ++ +L E
Sbjct: 397 IQ------LSEN-ICHSTFSAAADRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQEN 446
Query: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251
K ++ + + + + ++ ++EV +QL+ T++ M + T +
Sbjct: 447 EEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE----PTVQSLEMKPKTARNTPNQDFH 502
Query: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQ-- 1308
+E +DL + ++ + A+ E LEK+N LK + + K+
Sbjct: 503 NHEEVKDLMDENCILKTDI---------AILRQEICTMKNDNLEKENKYLKDIKIAKETN 553
Query: 1309 --MDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1366
++K +L + ++ ++E L L L L +E + +LE EI +++
Sbjct: 554 AALEKCIKLNEEMITKTAFWYQQE-LNDLKAENTRLNSELLKEKESKKKLEAEIESYQSR 612
Query: 1367 LKMTRKKLNEYENGEFSFHGDLK-----TSQFEMDIQINKLKHKIDDLTAELETAGSKCL 1421
L K +E E + L+ + Q +M I++++ K LT +L K
Sbjct: 613 LAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFN 672
Query: 1422 HLDTK----NQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477
L K L+++ L+++TVQ + Q+ K++++ M + + K
Sbjct: 673 TLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE------------MYQSAEAKV 720
Query: 1478 YKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESEL 1537
K + +E +L+ N +L+ Q E +E + +E R KDL E
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
Query: 1538 SKIKTSQE-DFNKTELEKYKQ 1557
K E D K L +Y++
Sbjct: 781 KNKKLMNEYDHLKESLFQYER 801
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 300 bits (769), Expect = 6e-81
Identities = 189/470 (40%), Positives = 281/470 (59%), Gaps = 41/470 (8%)
Query: 764 QRELSETK-----EIKSQLEHQKVEWERELCSLRFSLNQEE--EKRRNADTLYEKIREQL 816
+RE SE K E + + +K++ +C FS + ++R+ T ++ ++L
Sbjct: 374 RRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKL 433
Query: 817 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQD 876
KEE R ++ + + + ++ L + R +E ++Q +E A+ L+
Sbjct: 434 --KEEHDRCTLKQENEEKTNVNMLHKKNR----------EELERKEKQYKKEVEAKQLEP 481
Query: 877 GILTNHLSKQKEIEMAQKKMNS---ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN 933
+ + +EM K + ++ H+HEE KDL +N +L+ +IA+LR EI T+KN
Sbjct: 482 TV--------QSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKN 533
Query: 934 QNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 993
N EKE K +D+KI KE N L+K IK NEE +T+T Y L+ L AEN LNS+L
Sbjct: 534 DNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELL 593
Query: 994 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVS 1053
EK+SK++LEAE+ESY SRLAAAI ++ ++R L+LA +R +D Q KM+ D+S
Sbjct: 594 KEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISE--QVKMSSDIS 651
Query: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQ 1113
++D N L++QL K + K N+L+ +F TRD LR+K+L LE VQ DLSQTQ Q+KEM++
Sbjct: 652 EIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE 711
Query: 1114 KYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHA 1173
YQ+ + KV+K GK VEER+ QLQ EN L QQL D H K D+KE VINIQ F
Sbjct: 712 MYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF-- 768
Query: 1174 IVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223
ES K+ L+LEE+NK+L++E +HLKE +QYE +KAE V +++
Sbjct: 769 ------IESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
Score = 215 bits (547), Expect = 3e-55
Identities = 110/214 (51%), Positives = 151/214 (70%), Gaps = 15/214 (7%)
Query: 6 SKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQI 65
S++G++ LGS + Y+ GY +R +L KIHKAA G+ A++++
Sbjct: 8 SRRGQTVLGSI---------------DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERC 52
Query: 66 LLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQE 125
L R L+ DK +RTALHLACA+GH +VVTLLV+RKCQ+++ D ENRT L++AV CQE
Sbjct: 53 LARRSGDLDALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQE 112
Query: 126 EKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLL 185
E CA ILLEHGA+PNL D++GNTALHYAVY+E S+A KLL + NIEA +KD TPLL
Sbjct: 113 EACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLF 172
Query: 186 AVSGKKQQMVEFLIKKKANVNAVDKLESSHQLIS 219
A+ KK++MVEFL+K KA+ +AVD+L + +++
Sbjct: 173 AIICKKEKMVEFLLKNKASTHAVDRLRXTALMLA 206
Score = 93.6 bits (231), Expect = 1e-18
Identities = 151/672 (22%), Positives = 264/672 (39%), Gaps = 123/672 (18%)
Query: 375 DIIESAPLEQTNNDNLTYVDEVHKNNRSDM----MSALGLGQEEDIES--PWDSESIS-- 426
D S L + L + + KN++ D+ SA+ + E ++S D E +S
Sbjct: 237 DYAISCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVA 296
Query: 427 --ENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPV 484
+ P+K +PL G + GK I N + E G P
Sbjct: 297 AKQCVPEKVSEPLRGPSHGKGNRIVNGKGE--------------------------GPPA 330
Query: 485 AHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQ 543
H LKP+ EM+D A K+VQT +A E L VASEEEQ+R E SE Q
Sbjct: 331 KHPS-------LKPSTEMEDPAVKGAVQXKNVQTLRA-EQALPVASEEEQQRRERSEKKQ 382
Query: 544 PQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEY 603
PQV E +++ ++++S NI A D L Q+RK G+T QQFP+K +E+
Sbjct: 383 PQVIEGNNTYKSEKIQLSENICHSTFSAAA-----DRLTQQRKIGKTYPQQFPKKLKEEH 437
Query: 604 ASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRP 663
+ T K++ K +VN + + E++ E +
Sbjct: 438 D-----------RCTLKQENEEKTNVN----------------MLHKKNREELERKEKQY 470
Query: 664 TKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSV 723
K+ E +++ +QS++ ++ T ++D H K+ M D
Sbjct: 471 KKEV--EAKQLEPTVQSLEMKPKTARN--TPNQDFH-NHEEVKDLM-----------DEN 514
Query: 724 SLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVE 783
+LK D A+ + + +K ++ E K N +++ KE + LE
Sbjct: 515 CILK-TDIAILRQEICTMKNDNLE-----------KENKYLKDIKIAKETNAALEKCIKL 562
Query: 784 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 843
E + F QE + +T E L+ KE + + E E++ +
Sbjct: 563 NEEMITKTAFWYQQELNDLKAENTRLNS--ELLKEKESKKKLEAEIESYQSRLAAAISKH 620
Query: 844 LRTVKS--NLNQVVQERNDAQRQLSREQNARMLQD--GILTNHLSKQKEIEMAQKKMNSE 899
VK+ NL ++ D Q+ + ++D LT LSK Q K N+
Sbjct: 621 SENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM------QIKFNTL 674
Query: 900 NSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCFEDL---KIVKEKN 953
+ L K+ L Q +++ + +I +K Q E K + V+E+
Sbjct: 675 KDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
Query: 954 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRL 1013
LQ+ E+ L + + + V+ + + S+ ++ ++ + E H +
Sbjct: 735 CQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
Query: 1014 AAAIHDRDQSET 1025
+ ++R ++ET
Sbjct: 795 SLFQYERQKAET 806
Score = 57.4 bits (137), Expect = 1e-07
Identities = 103/501 (20%), Positives = 205/501 (40%), Gaps = 55/501 (10%)
Query: 1075 SLEIEFHHTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQVKVNKYIGKQES 1131
S E+E + A++ K + R ++ L S+ + Q +E +K Q + ++ N K E
Sbjct: 338 STEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQVIEGNNTY-KSEK 396
Query: 1132 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191
++ SEN + A ++ + K QF +KL+ E ++ +L E
Sbjct: 397 IQ------LSEN-ICHSTFSAAADRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQEN 446
Query: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251
K ++ + + + + ++ ++EV +QL+ T++ M + T +
Sbjct: 447 EEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE----PTVQSLEMKPKTARNTPNQDFH 502
Query: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQ-- 1308
+E +DL + ++ + A+ E LEK+N LK + + K+
Sbjct: 503 NHEEVKDLMDENCILKTDI---------AILRQEICTMKNDNLEKENKYLKDIKIAKETN 553
Query: 1309 --MDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1366
++K +L + ++ ++E L L L L +E + +LE EI +++
Sbjct: 554 AALEKCIKLNEEMITKTAFWYQQE-LNDLKAENTRLNSELLKEKESKKKLEAEIESYQSR 612
Query: 1367 LKMTRKKLNEYENGEFSFHGDLK-----TSQFEMDIQINKLKHKIDDLTAELETAGSKCL 1421
L K +E E + L+ + Q +M I++++ K LT +L K
Sbjct: 613 LAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFN 672
Query: 1422 HLDTK----NQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477
L K L+++ L+++TVQ + Q+ K++++ M + + K
Sbjct: 673 TLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE------------MYQSAEAKV 720
Query: 1478 YKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESEL 1537
K + +E +L+ N +L+ Q E +E + +E R KDL E
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
Query: 1538 SKIKTSQE-DFNKTELEKYKQ 1557
K E D K L +Y++
Sbjct: 781 KNKKLMNEYDHLKESLFQYER 801
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 299 bits (766), Expect = 1e-80
Identities = 185/447 (41%), Positives = 263/447 (58%), Gaps = 68/447 (15%)
Query: 780 QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839
+K++ E + C+L+ QE E++ N + LY+K RE+L RKE
Sbjct: 431 KKLKEEHDRCTLK----QENEEKTNVNMLYKKNREELERKE------------------- 467
Query: 840 LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 899
+Q +E A+ L+ + + +EM K +
Sbjct: 468 -----------------------KQYKKEVEAKQLEPTV--------QSLEMKSKTARNT 496
Query: 900 NS---HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDL 956
+ H+HEE K L +N +L+ +IA+LR EI T+KN N EKE K +D+KIVKE N L
Sbjct: 497 PNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAAL 556
Query: 957 QKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1016
+K IK NEE +T+T +Y L+ L AEN LN++L EK+SK+RLEA++ESY SRLAAA
Sbjct: 557 EKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
Query: 1017 IHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSL 1076
I +S ++R L+LA +R RD +Q +M+ +S +K NE L++QL +T+ K N+L
Sbjct: 617 ISKHSESVKTERNLKLALERTRD--VSVQVEMSSAISKVKAENEFLTEQLSETQIKFNAL 674
Query: 1077 EIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1136
+ +F TRD+LR+K+L LE VQ DLSQTQ Q +EM++ YQN + KVN GK VEER+
Sbjct: 675 KDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
Query: 1137 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL 1196
LQ EN L QQLDD H K D+KE V NIQ F ES K+ L+LEE++K+L
Sbjct: 735 CHLQRENAWLVQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKL 785
Query: 1197 ISECNHLKERQYQYENEKAEREVVVRQ 1223
++EC+HLKE +QYE EK E V +++
Sbjct: 786 MNECDHLKESLFQYEREKTEGVVSIKE 812
Score = 229 bits (585), Expect = 1e-59
Identities = 130/308 (42%), Positives = 182/308 (59%), Gaps = 44/308 (14%)
Query: 28 GEPGEGA----YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTA 83
G+ +G+ Y+ GY +RD +L KIH+AA G+ A+V++ L R L+ DK +RTA
Sbjct: 11 GQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTA 70
Query: 84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLAD 143
LHLAC +GH +VVTLLV+RKCQ++VCD ENRT L++AV CQEE CA ILLEHGA+PNL D
Sbjct: 71 LHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKD 130
Query: 144 VHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
++GNTALHYAVY+E S+A KLL + A+IEA +KD+ TPLL A+ KK++MVEFL+KKKA
Sbjct: 131 IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKA 190
Query: 204 NVNAVDKLESSHQLISEY---------------------------KEERIPKHSSQNSNS 236
+ +AVD+L S +++ Y ++ I H ++
Sbjct: 191 SSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQ 250
Query: 237 VDESSEDSLSRLSGKPGVD-------------DSWPTSDDEDLNFDTKNVPKPSLAKLMT 283
+ E + L + G DS P SDD+DLN TK +++ +
Sbjct: 251 ILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLP 310
Query: 284 ASQQSRKN 291
S + N
Sbjct: 311 GSSHEKGN 318
Score = 107 bits (266), Expect = 1e-22
Identities = 152/666 (22%), Positives = 281/666 (42%), Gaps = 111/666 (16%)
Query: 412 QEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKM 471
++ D+ S ES F + VD L A+D K+ N+ +Q + + GS + K
Sbjct: 262 EKSDVGS--SDESAVSIFHELRVDSLP-ASDDKDLNVATKQCVPE-KVSEPLPGSSHEKG 317
Query: 472 AKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASE 531
++ + + G P H LKP+ E++D A K+VQT +A E L VASE
Sbjct: 318 NRIVNGQGEGPPAKHPS-------LKPSTEVEDPAVKGAVQRKNVQTLRA-EQALPVASE 369
Query: 532 EEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 590
EEQER E SE QPQV+E +++ ++++S NI D + A L Q+RK G+T
Sbjct: 370 EEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAA-----GRLTQQRKIGKT 424
Query: 591 DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 650
QQFP+K +E+ + T K++ K +VN ++ K
Sbjct: 425 YPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM-LYKK-------------- 458
Query: 651 SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 710
+ E++ E + K+ E +++ +QS++ S+TA P+ + N
Sbjct: 459 -NREELERKEKQYKKEV--EAKQLEPTVQSLE------MKSKTAR---NTPNWDFHNHE- 505
Query: 711 LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 770
E G+ D +LK D A+ + + +K ++ E K N +++
Sbjct: 506 --EMKGL--MDENCILK-ADIAILRQEICTMKNDNLE-----------KENKYLKDIKIV 549
Query: 771 KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 830
KE + LE E + F QE ++ + R + KE E K
Sbjct: 550 KETNAALEKYIKLNEEMITETAFRYQQE----------LNDLKAENTRLNAELLKEKESK 599
Query: 831 QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIE 890
++LE +++ + L S ++ V+ + + L R T +S Q E+
Sbjct: 600 KRLEADIESYQSRLAAAISKHSESVKTERNLKLALER------------TRDVSVQVEMS 647
Query: 891 MAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVK 950
A K+ +EN E+ + K + L+++ R D+++ ++ E DL +
Sbjct: 648 SAISKVKAENEFLTEQLSETQIKFNALKDKFRKTR---DSLRKKSLALE-TVQNDLSQTQ 703
Query: 951 EKNEDLQKTIKQNEETLTQTISQYN---GRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
++ +++++ + E + + ++N R+ L ENA L +L++ Q ++ E
Sbjct: 704 QQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTN 763
Query: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKM-NFDVSNLKDNNEILSQQL 1066
+ + D E SK+ + +EC L++ + ++ + I +
Sbjct: 764 IQRGFIESGKKDLVLEEKSKKLM--------NECDHLKESLFQYEREKTEGVVSIKEDKY 815
Query: 1067 FKTESK 1072
F+T K
Sbjct: 816 FQTSRK 821
Score = 43.5 bits (101), Expect = 0.002
Identities = 113/618 (18%), Positives = 233/618 (37%), Gaps = 146/618 (23%)
Query: 906 EEKDLSHKNSMLQEEIAMLRLE--IDTIKNQNQEKEKKCFEDLKIVKE-KNEDLQKTIKQ 962
E +D + K ++ ++ + LR E + + QE+ ++ + VKE N + + I+
Sbjct: 340 EVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQL 399
Query: 963 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQ 1022
+E T S GRL+ + + K ++ +++ H R Q
Sbjct: 400 SENICDSTSSAAAGRLT----------QQRKIGKTYPQQFPKKLKEEHDRCTLK-----Q 444
Query: 1023 SETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHH 1082
K + + +++ R+E R + + +V + + S ++ K+++ N+ +FH+
Sbjct: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEM-KSKTARNTPNWDFHN 503
Query: 1083 TRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1142
+ K L C +K ++
Sbjct: 504 HEE------------MKGLMDENCILK-------------------------------AD 520
Query: 1143 NMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNH 1202
+LRQ++ N DN EK ++D IV++ A EK L N+E+I+E
Sbjct: 521 IAILRQEICTMKN--DNLEKENKYLKDI--KIVKETNAALEKYIKL----NEEMITET-- 570
Query: 1203 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKK 1262
++Y+ E + + +L EL + + EA +E
Sbjct: 571 ----AFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIE------------------- 607
Query: 1263 LGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD-NAKLKVTVKKQMDKIEELQKNLLN 1321
+++L A +H+E+V+ + K LE+ + ++V + + K++ N
Sbjct: 608 --SYQSRLAAAISKHSESVKTERNL---KLALERTRDVSVQVEMSSAISKVKAE-----N 657
Query: 1322 ANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGE 1381
L+E E K LK D KK++ LE + T++ Y+N E
Sbjct: 658 EFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE 717
Query: 1382 FSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQ 1441
K+++ T + + HL +N L ++L +
Sbjct: 718 ----------------------AKVNNSTGKWNCVEERICHLQRENAWLVQQLDDV---- 751
Query: 1442 KKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1501
++K+ +E++ ++I+R +E G+ +E ++ E + LKE +LF
Sbjct: 752 --------HQKEDHKEIV---TNIQRGFIESGKKDLVLEEKSKKLMNE-CDHLKE-SLF- 797
Query: 1502 QAQAASQENLEQFRENNF 1519
Q + E + +E+ +
Sbjct: 798 QYEREKTEGVVSIKEDKY 815
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 297 bits (760), Expect = 7e-80
Identities = 183/447 (40%), Positives = 263/447 (58%), Gaps = 68/447 (15%)
Query: 780 QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839
+K++ E + C+L+ QE E++ N + LY+K RE+L RKE
Sbjct: 431 KKLKEEHDRCTLK----QENEEKTNVNMLYKKNREELERKE------------------- 467
Query: 840 LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 899
+Q +E A+ L+ + + +EM K +
Sbjct: 468 -----------------------KQYKKEVEAKQLEPTV--------QSLEMKSKTARNT 496
Query: 900 NS---HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDL 956
+ H+HEE K L +N +L+ +IA+LR EI T+KN N EKE K +D+KIVKE N L
Sbjct: 497 PNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAAL 556
Query: 957 QKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1016
+K IK NEE +T+T +Y L+ L AEN LN++L EK+SK+RLEA++ESY SRLAAA
Sbjct: 557 EKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
Query: 1017 IHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSL 1076
I +S ++R L+LA +R +D +Q +M+ +S +KD NE L++QL +T+ K N+L
Sbjct: 617 ISKHSESVKTERNLKLALERTQD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNAL 674
Query: 1077 EIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1136
+ +F TRD+LR+K+L LE VQ +LSQTQ Q +EM++ YQN + KVN GK VEER+
Sbjct: 675 KDKFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
Query: 1137 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL 1196
LQ EN L QQLDD H K D+KE V NIQ F ES K+ +LEE++K+L
Sbjct: 735 CHLQRENAWLVQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDFVLEEKSKKL 785
Query: 1197 ISECNHLKERQYQYENEKAEREVVVRQ 1223
++EC+HLKE +QYE EK E V +++
Sbjct: 786 MNECDHLKESLFQYEREKTEVVVSIKE 812
Score = 231 bits (588), Expect = 6e-60
Identities = 131/308 (42%), Positives = 183/308 (59%), Gaps = 44/308 (14%)
Query: 28 GEPGEGA----YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTA 83
G+ +G+ Y+ GY +RD +L KIH+AA G+ A+V++ L R L+ DK +RTA
Sbjct: 11 GQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGELDALDKQHRTA 70
Query: 84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLAD 143
LHLACA+GH +VVTLLV+RKCQ++VCD ENRT L++AV CQEE CA ILLEHGA+PNL D
Sbjct: 71 LHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKD 130
Query: 144 VHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
++GNTALHYAVY+E S+A KLL + A+IEA +KD+ TPLL A+ KK++MVEFL+KKKA
Sbjct: 131 IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKA 190
Query: 204 NVNAVDKLESSHQLISEY---------------------------KEERIPKHSSQNSNS 236
+ +AVD+L S +++ Y ++ I H ++
Sbjct: 191 SSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQ 250
Query: 237 VDESSEDSLSRLSGKPGVD-------------DSWPTSDDEDLNFDTKNVPKPSLAKLMT 283
+ E + L + G DS P SDD+DLN TK +++ +
Sbjct: 251 ILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLP 310
Query: 284 ASQQSRKN 291
S + N
Sbjct: 311 GSSHEKGN 318
Score = 103 bits (256), Expect = 2e-21
Identities = 148/643 (23%), Positives = 276/643 (42%), Gaps = 114/643 (17%)
Query: 412 QEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKM 471
++ D+ S ES F + VD L A+D K+ N+ +Q + + GS + K
Sbjct: 262 EKSDVGS--SDESAVSIFHELRVDSLP-ASDDKDLNVATKQCVPE-KVSEPLPGSSHEKG 317
Query: 472 AKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASE 531
++ + + G P H LKP+ E++D A K+VQT +A E L VASE
Sbjct: 318 NRIVNGQGEGPPAKHPS-------LKPSTEVEDPAVKGAVQRKNVQTLRA-EQALPVASE 369
Query: 532 EEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 590
EEQ+R E SE QPQV+E +++ ++++S NI D + A L Q+RK G+T
Sbjct: 370 EEQQRHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAA-----GRLTQQRKIGKT 424
Query: 591 DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 650
QQFP+K +E+ + T K++ K +VN ++ K
Sbjct: 425 YPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM-LYKK-------------- 458
Query: 651 SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 710
+ E++ E + K+ E +++ +QS++ S+TA P+ + N
Sbjct: 459 -NREELERKEKQYKKEV--EAKQLEPTVQSLE------MKSKTAR---NTPNWDFHNHE- 505
Query: 711 LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 770
E G+ D +LK D A+ + + +K ++ E K N +++
Sbjct: 506 --EMKGL--MDENCILK-ADIAILRQEICTMKNDNLE-----------KENKYLKDIKIV 549
Query: 771 KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 830
KE + LE E + F QE ++ + R + KE E K
Sbjct: 550 KETNAALEKYIKLNEEMITETAFRYQQE----------LNDLKAENTRLNAELLKEKESK 599
Query: 831 QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIE 890
++LE +++ + L S ++ V+ + + L R Q+ +S Q E+
Sbjct: 600 KRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTQD------------VSVQVEMS 647
Query: 891 MAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVK 950
A K+ EN E+ + K + L+++ R D+++ ++ E +L +
Sbjct: 648 SAISKVKDENEFLTEQLSETQIKFNALKDKFRKTR---DSLRKKSLALE-TVQNNLSQTQ 703
Query: 951 EKNEDLQKTIKQNEETLTQTISQYN---GRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007
++ +++++ + E + + ++N R+ L ENA L +L++ Q ++
Sbjct: 704 QQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKED------- 756
Query: 1008 SYHSRLAAAIHDRDQSETSKRE--LELAFQRARDECSRLQDKM 1048
H + I R E+ K++ LE ++ +EC L++ +
Sbjct: 757 --HKEIVTNI-QRGFIESGKKDFVLEEKSKKLMNECDHLKESL 796
Score = 43.9 bits (102), Expect = 0.001
Identities = 93/509 (18%), Positives = 203/509 (39%), Gaps = 79/509 (15%)
Query: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
++SE + +++ + E +L + + S+ +++ KT + +++
Sbjct: 376 ERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKE 435
Query: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
H R L+++ V + + +++ E++Y+ E + + +E + L+
Sbjct: 436 EHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEV--------EAKQLEPTVQSLE 487
Query: 1141 SENMLLRQQLD-DAHNKADNKE--------KTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191
++ R + D HN + K K I I Q ++ E E + L
Sbjct: 488 MKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL---- 543
Query: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251
++ +++ E N E+ Y NE+ E R QQEL D + + A L +
Sbjct: 544 KDIKIVKETNAALEK-YIKLNEEMITETAFRY-QQELNDLKAENTRLNAEL-------LK 594
Query: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMD 1310
++ + L+ + +++L A +H+E+V+ + K LE+ + ++V + +
Sbjct: 595 EKESKKRLEADIESYQSRLAAAISKHSESVKTERNL---KLALERTQDVSVQVEMSSAIS 651
Query: 1311 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1370
K+++ N L+E E K LK D KK++ LE + T
Sbjct: 652 KVKDE-----NEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNNLSQTQQQT 706
Query: 1371 RKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQIL 1430
++ Y+N E K+++ T + + HL +N L
Sbjct: 707 QEMKEMYQNAE----------------------AKVNNSTGKWNCVEERICHLQRENAWL 744
Query: 1431 QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1490
++L + ++K+ +E++ ++I+R +E G+ K + E + +
Sbjct: 745 VQQLDDV------------HQKEDHKEIV---TNIQRGFIESGK-KDFVLEEKSKKLMNE 788
Query: 1491 AEKLKEVNLFLQAQAASQENLEQFRENNF 1519
+ LKE +LF Q + E + +E+ +
Sbjct: 789 CDHLKE-SLF-QYEREKTEVVVSIKEDKY 815
>gi|50897294 POTE ankyrin domain family, member A isoform 1 [Homo
sapiens]
Length = 452
Score = 268 bits (685), Expect = 3e-71
Identities = 137/252 (54%), Positives = 185/252 (73%), Gaps = 4/252 (1%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+++ G + + A+++P YHVR DLGK+H+AA G V + I++LR G+N RDK
Sbjct: 40 KNNMGAWRDHDDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKK 99
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLACANG+ EVV+LL+DR+CQL+V D++ RTAL+KAVQCQE++CA +LL+HG DPN
Sbjct: 100 RTALHLACANGNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPN 159
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
L D++GNTALHYAVYNED +A LLLY A+IE+KNK LTPLLLAV G+KQ+MV+FLIK
Sbjct: 160 LPDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIK 219
Query: 201 KKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSGKPGVDDS 257
KKAN+NA+D+ QL+S+YKE ++P +SS NSN + +SE+ RL G
Sbjct: 220 KKANLNALDRFGRICQLLSDYKENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHE 279
Query: 258 WPTSDDEDLNFD 269
+ + D+N D
Sbjct: 280 -KVTQEPDINKD 290
Score = 124 bits (310), Expect = 1e-27
Identities = 96/279 (34%), Positives = 142/279 (50%), Gaps = 84/279 (30%)
Query: 503 KDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQ---------------V 546
++ +PN + G + E DL++ SEEE +R +GSEN+Q + V
Sbjct: 242 ENQMPNNSSGNSN------PEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREV 295
Query: 547 EEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASS 606
EEE +KH +N + +S + TD A +G D P+++++
Sbjct: 296 EEEMQKHGSNNVGLS----ENLTDGAA-------------AGNGDGGLVPQRKSR----- 333
Query: 607 GPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKK 666
K +++ N+ + E+ RP KK
Sbjct: 334 ---------------KHENQQFPNTEI------------------------EEYHRPEKK 354
Query: 667 TSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLL 726
SNEKNKVK+QI S+D++DD+T SE ASED +L S+Y+ F LLIEQL M+ DS SL
Sbjct: 355 -SNEKNKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLS 413
Query: 727 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQR 765
KIQDA +S E LLELK +H E LTV++++ME+ V+VLQ+
Sbjct: 414 KIQDAVISEEHLLELKNSHYEQLTVEVEQMENMVHVLQK 452
>gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo
sapiens]
Length = 498
Score = 250 bits (639), Expect = 7e-66
Identities = 140/298 (46%), Positives = 188/298 (63%), Gaps = 50/298 (16%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+++ G + + A+++P YHVR DLGK+H+AA G V + I++LR G+N RDK
Sbjct: 40 KNNMGAWRDHDDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKK 99
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLACANG+ EVV+LL+DR+CQL+V D++ RTAL+KAVQCQE++CA +LL+HG DPN
Sbjct: 100 RTALHLACANGNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPN 159
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
L D++GNTALHYAVYNED +A LLLY A+IE+KNK LTPLLLAV G+KQ+MV+FLIK
Sbjct: 160 LPDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIK 219
Query: 201 KKANVNAVDKL-----------------------------------------ESSH---- 215
KKAN+NA+D+ SSH
Sbjct: 220 KKANLNALDRFGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSII 279
Query: 216 -QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSGKPGVDDSWPTSDDEDLNFD 269
QL+S+YKE ++P +SS NSN + +SE+ RL G + + D+N D
Sbjct: 280 CQLLSDYKENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHE-KVTQEPDINKD 336
Score = 124 bits (310), Expect = 1e-27
Identities = 96/279 (34%), Positives = 142/279 (50%), Gaps = 84/279 (30%)
Query: 503 KDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQ---------------V 546
++ +PN + G + E DL++ SEEE +R +GSEN+Q + V
Sbjct: 288 ENQMPNNSSGNSN------PEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREV 341
Query: 547 EEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASS 606
EEE +KH +N + +S + TD A +G D P+++++
Sbjct: 342 EEEMQKHGSNNVGLS----ENLTDGAA-------------AGNGDGGLVPQRKSR----- 379
Query: 607 GPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKK 666
K +++ N+ + E+ RP KK
Sbjct: 380 ---------------KHENQQFPNTEI------------------------EEYHRPEKK 400
Query: 667 TSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLL 726
SNEKNKVK+QI S+D++DD+T SE ASED +L S+Y+ F LLIEQL M+ DS SL
Sbjct: 401 -SNEKNKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLS 459
Query: 727 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQR 765
KIQDA +S E LLELK +H E LTV++++ME+ V+VLQ+
Sbjct: 460 KIQDAVISEEHLLELKNSHYEQLTVEVEQMENMVHVLQK 498
>gi|134133226 protein expressed in prostate, ovary, testis, and
placenta 2 [Homo sapiens]
Length = 1075
Score = 239 bits (610), Expect = 2e-62
Identities = 138/298 (46%), Positives = 183/298 (61%), Gaps = 52/298 (17%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+S G G+ + A+ +P YHVR DL K+H+AA G V + I++LR +N +DK
Sbjct: 114 KSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQK 173
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLA ANG+ EVV LL+DR+CQLNV DN+ RTAL+KAVQCQE++CA +LLEHG DPN
Sbjct: 174 RTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPN 233
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
+ D +GNT LHYA+YNED +A LLLY A+IE+KNK LTPLLL V +KQQ+V+FLIK
Sbjct: 234 IPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIK 293
Query: 201 KKANVNAVDK---------------------LE--------------------SSH---- 215
KKAN+NA+D+ LE SSH
Sbjct: 294 KKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVI 353
Query: 216 -QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSGKPGVDDSWPTSDDEDLNFD 269
QL+S+YKE+++ K SS+NSN E +SE+ R G ++S P ++L +
Sbjct: 354 CQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKGS---ENSQPEKMSQELEIN 408
Score = 106 bits (264), Expect = 2e-22
Identities = 57/111 (51%), Positives = 84/111 (75%), Gaps = 4/111 (3%)
Query: 857 ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSM 916
E+ND Q+Q EQN +L D IL + ++K+IE+ +K MNSE S S ++EKD+ H+NS
Sbjct: 595 EQNDTQKQFCEEQNTGILHDEIL---IHEEKQIEVVEK-MNSELSLSCKKEKDVLHENST 650
Query: 917 LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETL 967
L+EEIAMLRLE+DT+K+Q+Q +EKK ED++ VK+KN++L K ++ NE T+
Sbjct: 651 LREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTM 701
Score = 71.6 bits (174), Expect = 6e-12
Identities = 76/348 (21%), Positives = 147/348 (42%), Gaps = 64/348 (18%)
Query: 523 EHDLEVASEEEQER-EGSENNQPQ---------------VEEERKKHRNNEMEVSANIHD 566
E +L++ SEEE +R +GSEN+QP+ VEEE KKH +N + + N+ +
Sbjct: 376 EQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTN 435
Query: 567 GATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSK 626
G T + D+GLI +RKS ++QQFP E++EY ++ E+ S KEK+ K
Sbjct: 436 GVTAG----NGDNGLIPQRKSRTPENQQFPDNESEEYH------RICELLSDYKEKQMPK 485
Query: 627 ESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDD 686
S + + + L E+E + K + N + + ++Q ++ D
Sbjct: 486 YSSENS---------------NPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGD 530
Query: 687 LTQSSETASEDCELPHSSYKNFML--------------LIEQLGMECKDSVSLLKIQDAA 732
+ A E+ + S++ F LI +S ++
Sbjct: 531 RELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEE 590
Query: 733 LSCERLLELKKNHCE---------LLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVE 783
+ + +K CE + + +K + V + ELS + + + + H+
Sbjct: 591 YHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDVLHENST 650
Query: 784 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 831
E+ LR L+ + + + + Y + E +++K + K +++ +
Sbjct: 651 LREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNE 698
Score = 55.8 bits (133), Expect = 3e-07
Identities = 125/637 (19%), Positives = 244/637 (38%), Gaps = 95/637 (14%)
Query: 675 KNQIQSMDDVDD---LTQSSETASEDCELPHSSY-------KNFMLLIEQLGMECKDSV- 723
K+++ + D DD + ED + H + K+ ++++ + KD
Sbjct: 114 KSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQK 173
Query: 724 -SLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEH--- 779
+ L + A + E + L C+L + KK + +Q + E + LEH
Sbjct: 174 RTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALML--LEHGTD 231
Query: 780 QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK---------EEQYRKEVEVK 830
+ E +L +++ E++ A LY E + EQ ++ V+
Sbjct: 232 PNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFL 291
Query: 831 QQLELSLQTLEMELRTV---------KSNLNQVVQERNDAQRQLSREQNARML----QDG 877
+ + +L L+ RT S ++ ++++ D Q Q AR
Sbjct: 292 IKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHH 351
Query: 878 ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE 937
++ LS KE +M K++SENS+ +E K S + S K
Sbjct: 352 VICQLLSDYKEKQML--KISSENSNPEQELKLTSEEESQ-------------RFKGSENS 396
Query: 938 KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 997
+ +K ++L+I K+ + ++++ +K++E + ++ +N ++ + +
Sbjct: 397 QPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPE 456
Query: 998 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKD 1057
+++ + E E YH R+ + D + + K E + +LK
Sbjct: 457 NQQFPDNESEEYH-RICELLSDYKEKQMPKYSSENSNPE----------------QDLKL 499
Query: 1058 NNEILSQQLFKTES---KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1114
+E SQ+L +E+ + S E E + D E + +E ++K S T E
Sbjct: 500 TSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGS-THVGFPE---N 555
Query: 1115 YQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAI 1174
N N G + R S+ + ++ H+ N + + +
Sbjct: 556 LTNGATAGN---GDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGIL 612
Query: 1175 VQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1234
++ EKQ ++E+ N EL C KE+ +EN E+ + +L+ DT+K
Sbjct: 613 HDEILIHEEKQIEVVEKMNSELSLSCK--KEKDVLHENSTLREEIAMLRLE---LDTMKH 667
Query: 1235 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQ 1271
QS R + LED + +KKK + LQ
Sbjct: 668 QSQ--------LREKKYLED-IESVKKKNDNLLKALQ 695
Score = 47.4 bits (111), Expect = 1e-04
Identities = 53/225 (23%), Positives = 99/225 (44%), Gaps = 35/225 (15%)
Query: 61 KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA 120
+V + L+ +K LN D+ RTAL LA G +V+LL+++ ++ D +TA A
Sbjct: 286 QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYA 345
Query: 121 VQCQEEKCATILLEHGADPNL--ADVHGNTALHYAVYNEDIS-------------VATKL 165
V +L ++ L + + N + +E+ S ++ +L
Sbjct: 346 VSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQEL 405
Query: 166 LLY---DANIEAKNK----------DDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLE 212
+ D +E + K ++LT + A +G + + + N D
Sbjct: 406 EINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNES 465
Query: 213 SSH----QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSG 250
+ +L+S+YKE+++PK+SS+NSN + +SE+ RL G
Sbjct: 466 EEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKG 510
Score = 40.0 bits (92), Expect = 0.019
Identities = 79/388 (20%), Positives = 147/388 (37%), Gaps = 43/388 (11%)
Query: 1143 NMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNH 1202
++LL Q +D + + + H I Q L EKQ L + N E
Sbjct: 322 SLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKL 381
Query: 1203 LKERQYQ--YENEKAEREVVVRQLQ------QELADTLKKQSMSEASL--EVTSRYRINL 1252
E + Q +E ++ E + ++L+ +E+ + +KK + L +T+
Sbjct: 382 TSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGN 441
Query: 1253 EDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI 1312
D ++K NQ Q + E R E + D+K+ KQM K
Sbjct: 442 GDNGLIPQRKSRTPENQ-QFPDNESEEYHRICELLSDYKE--------------KQMPKY 486
Query: 1313 EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRK 1372
N +L +E+ ++L + QE + N + +RE+ F + +M +
Sbjct: 487 SSENSN-PEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKH 545
Query: 1373 KL------NEYENGEFSFHGD-----LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCL 1421
NG + +GD + S+ Q +++ + +T C
Sbjct: 546 GSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCE 605
Query: 1422 HLDT---KNQILQEELLSMKTVQKKCEKLQ---KNKKKLEQEVINLRSHIERNMVELGQV 1475
+T ++IL E ++ V+K +L K +K + E LR I +EL +
Sbjct: 606 EQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDVLHENSTLREEIAMLRLELDTM 665
Query: 1476 KQYKQEIEERARQEIAEKLKEVNLFLQA 1503
K Q E++ ++I K+ + L+A
Sbjct: 666 KHQSQLREKKYLEDIESVKKKNDNLLKA 693
Score = 36.2 bits (82), Expect = 0.28
Identities = 82/411 (19%), Positives = 168/411 (40%), Gaps = 77/411 (18%)
Query: 761 NVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR---NADTLYEKIREQLR 817
+V+ + LS+ KE K L K+ E L EEE +R + ++ EK+ ++L
Sbjct: 351 HVICQLLSDYKE-KQML---KISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELE 406
Query: 818 RKEEQYRK-EVEVKQQLELSLQTLEMELR--TVKSNLNQVVQERNDAQRQLSREQNARML 874
++ R+ E E+K+ ++ LE T + N ++ +R + + +
Sbjct: 407 INKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESE 466
Query: 875 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQ 934
+ + LS KE +M K +SENS+ ++ K S + S +K
Sbjct: 467 EYHRICELLSDYKEKQMP--KYSSENSNPEQDLKLTSEEESQ-------------RLKGS 511
Query: 935 NQEKEKKCFEDLKIVKEKNEDLQKTIKQNE------------ETLTQTISQYNGRLSVLT 982
+ +K ++ +I K+ + +L+ + E E LT + NG
Sbjct: 512 ENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNG------ 565
Query: 983 AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECS 1042
++ ++ + +S++ + E E YHS +Q++T K+ E
Sbjct: 566 -DDGLIPPRKSRTPESQQFPDTENEEYHSD--------EQNDTQKQFCE----------- 605
Query: 1043 RLQDKMNFDVSNLKDNNEILSQQLFKTESKLNS-LEIEFHHTRDALREKTLGLERVQKDL 1101
+ N + L D I ++ + K+NS L + +D L E + +++++
Sbjct: 606 ----EQNTGI--LHDEILIHEEKQIEVVEKMNSELSLSCKKEKDVLHENST----LREEI 655
Query: 1102 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDD 1152
+ + ++ M+ + Q++ KY+ ESV+++ L L +DD
Sbjct: 656 AMLRLELDTMKHQ---SQLREKKYLEDIESVKKKNDNLLKALQLNELTMDD 703
>gi|224282147 prostate-specific P704P [Homo sapiens]
Length = 508
Score = 237 bits (605), Expect = 6e-62
Identities = 132/279 (47%), Positives = 174/279 (62%), Gaps = 49/279 (17%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+S G G+ + A+ +P YHVR DL K+H+AA G V + I++L+ +N +DK
Sbjct: 114 KSKVGPWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQK 173
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLA ANG+ EVV LL+DR+CQLN+ DN+ RTAL KAVQCQE++CA +LLEHG DPN
Sbjct: 174 RTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPN 233
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
+ D +GNTALHYA+YNED +A LLLY A+IE+KNK LTPLLL V +KQQ+V+FLIK
Sbjct: 234 IPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIK 293
Query: 201 KKANVNAVDK------------------------------------------LESSH--- 215
KKAN+NA+D+ + S H
Sbjct: 294 KKANLNALDRYGRTVLILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVI 353
Query: 216 -QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSG 250
QL+S+YKE++I K SS+NSN + +SE+ RL G
Sbjct: 354 CQLLSDYKEKQILKVSSENSNPEQDLKLTSEEESQRLKG 392
Score = 68.6 bits (166), Expect = 5e-11
Identities = 43/99 (43%), Positives = 56/99 (56%), Gaps = 20/99 (20%)
Query: 523 EHDLEVASEEEQER-EGSENNQPQ---------------VEEERKKHRNNEMEVSANIHD 566
E DL++ SEEE +R +GSEN+QP+ VEEE KKH + M N+ +
Sbjct: 376 EQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHGSTHMGFPENLPN 435
Query: 567 GATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYAS 605
GAT D + DDGLI RKS + QQFP EN++Y S
Sbjct: 436 GATAD----NGDDGLIPPRKSRTPESQQFPDTENEQYHS 470
Score = 38.5 bits (88), Expect = 0.057
Identities = 19/39 (48%), Positives = 29/39 (74%), Gaps = 3/39 (7%)
Query: 857 ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK 895
E+ND Q+QLS EQN +LQD IL + ++K+IE+A+ +
Sbjct: 472 EQNDTQKQLSEEQNTGILQDEIL---IHEEKQIEVAENE 507
>gi|153791352 prostate, ovary, testis expressed protein on
chromosome 2 [Homo sapiens]
Length = 1075
Score = 237 bits (605), Expect = 6e-62
Identities = 139/300 (46%), Positives = 185/300 (61%), Gaps = 54/300 (18%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+S G G+ + A+ +P YHVR DL K+H+AA G V + I++LR +N +DK
Sbjct: 114 KSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQK 173
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLA ANG+ EVV LL+DR+CQLNV DN+ RTAL+KAVQCQE++CA +LLEHG DPN
Sbjct: 174 RTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPN 233
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
+ D +GNT LHYA+YNED +A LLLY A+IE+KNK LTPLLL V +KQQ+V+FLIK
Sbjct: 234 IPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIK 293
Query: 201 KKANVNAVDK---------------------LE--------------------SSH---- 215
KKAN+NA+D+ LE SSH
Sbjct: 294 KKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVI 353
Query: 216 -QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSGKPGVDDSWP--TSDDEDLNFD 269
QL+S+YKE+++ K SS+NSN + +SE+ R G ++S P S + ++N D
Sbjct: 354 CQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGS---ENSQPEKMSQEPEINKD 410
Score = 105 bits (262), Expect = 4e-22
Identities = 56/111 (50%), Positives = 84/111 (75%), Gaps = 4/111 (3%)
Query: 857 ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSM 916
E+ND Q+Q EQN +L D IL + ++K+IE+ +K MNSE S S ++EKD+ H+NS
Sbjct: 595 EQNDTQKQFCEEQNTGILHDEIL---IHEEKQIEVVEK-MNSELSLSCKKEKDILHENST 650
Query: 917 LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETL 967
L+EEIAMLRLE+DT+K+Q+Q +EKK ED++ VK++N++L K ++ NE T+
Sbjct: 651 LREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLKALQLNELTM 701
Score = 73.2 bits (178), Expect = 2e-12
Identities = 76/348 (21%), Positives = 147/348 (42%), Gaps = 64/348 (18%)
Query: 523 EHDLEVASEEEQER-EGSENNQPQ---------------VEEERKKHRNNEMEVSANIHD 566
E DL++ SEEE +R +GSEN+QP+ VEEE KKH +N + + N+ +
Sbjct: 376 EQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTN 435
Query: 567 GATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSK 626
G T + D+GLI +RKS ++QQFP E++EY ++ E+ S KEK+ K
Sbjct: 436 GVTAG----NGDNGLIPQRKSRTPENQQFPDNESEEYH------RICELLSDYKEKQMPK 485
Query: 627 ESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDD 686
S + + + L E+E + K + N + + ++Q ++ D
Sbjct: 486 YSSENS---------------NPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGD 530
Query: 687 LTQSSETASEDCELPHSSYKNFML--------------LIEQLGMECKDSVSLLKIQDAA 732
+ A E+ + S++ F LI +S ++
Sbjct: 531 RELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEE 590
Query: 733 LSCERLLELKKNHCE---------LLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVE 783
+ + +K CE + + +K + V + ELS + + + + H+
Sbjct: 591 YHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDILHENST 650
Query: 784 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 831
E+ LR L+ + + + + Y + E ++++ + K +++ +
Sbjct: 651 LREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLKALQLNE 698
Score = 51.2 bits (121), Expect = 8e-06
Identities = 107/556 (19%), Positives = 212/556 (38%), Gaps = 74/556 (13%)
Query: 709 MLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELS 768
ML + + K + L + A + E + L C+L + KK + +Q +
Sbjct: 160 MLRDTDVNKQDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQED 219
Query: 769 ETKEIKSQLEH---QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK------ 819
E + LEH + E +L +++ E++ A LY E +
Sbjct: 220 ECALML--LEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLL 277
Query: 820 ---EEQYRKEVEVKQQLELSLQTLEMELRTV---------KSNLNQVVQERNDAQRQLSR 867
EQ ++ V+ + + +L L+ RT S ++ ++++ D Q
Sbjct: 278 LGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLS 337
Query: 868 EQNARML----QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM 923
Q AR ++ LS KE +M K++SENS+ ++ K S + S
Sbjct: 338 GQTAREYAVSSHHHVICQLLSDYKEKQML--KISSENSNPEQDLKLTSEEESQ------- 388
Query: 924 LRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTA 983
K + +K ++ +I K+ + ++++ +K++E + ++
Sbjct: 389 ------RFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNG 442
Query: 984 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSR 1043
+N ++ + ++++ + E E YH R+ + D + + K E +
Sbjct: 443 DNGLIPQRKSRTPENQQFPDNESEEYH-RICELLSDYKEKQMPKYSSENSNPE------- 494
Query: 1044 LQDKMNFDVSNLKDNNEILSQQLFKTES---KLNSLEIEFHHTRDALREKTLGLERVQKD 1100
+LK +E SQ+L +E+ + S E E + D E + +E ++K
Sbjct: 495 ---------QDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKH 545
Query: 1101 LSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1160
S T E N N G + R S+ + ++ H+ N
Sbjct: 546 RS-THVGFPE---NLTNGATAGN---GDDGLIPPRKSRTPESQQFPDTENEEYHSDEQND 598
Query: 1161 EKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVV 1220
+ + + ++ EKQ ++E+ N EL C KE+ +EN E+
Sbjct: 599 TQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCK--KEKDILHENSTLREEIA 656
Query: 1221 VRQLQQELADTLKKQS 1236
+ +L+ DT+K QS
Sbjct: 657 MLRLE---LDTMKHQS 669
Score = 45.8 bits (107), Expect = 4e-04
Identities = 53/225 (23%), Positives = 95/225 (42%), Gaps = 35/225 (15%)
Query: 61 KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA 120
+V + L+ +K LN D+ RTAL LA G +V+LL+++ ++ D +TA A
Sbjct: 286 QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYA 345
Query: 121 VQCQEEKCATILLEHGADPNL--ADVHGNTALHYAVYNEDISVATKLLLY---------- 168
V +L ++ L + + N + +E+ S K
Sbjct: 346 VSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEP 405
Query: 169 ------DANIEAKNK----------DDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLE 212
D +E + K ++LT + A +G + + + N D
Sbjct: 406 EINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNES 465
Query: 213 SSH----QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSG 250
+ +L+S+YKE+++PK+SS+NSN + +SE+ RL G
Sbjct: 466 EEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKG 510
Score = 39.3 bits (90), Expect = 0.033
Identities = 78/388 (20%), Positives = 144/388 (37%), Gaps = 43/388 (11%)
Query: 1143 NMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNH 1202
++LL Q +D + + + H I Q L EKQ L + N +
Sbjct: 322 SLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKL 381
Query: 1203 LKERQYQ----YENEKAER----EVVVRQLQQELADTLKKQSMSEASL--EVTSRYRINL 1252
E + Q EN + E+ + + +E+ + +KK + L +T+
Sbjct: 382 TSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGN 441
Query: 1253 EDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI 1312
D ++K NQ Q + E R E + D+K+ KQM K
Sbjct: 442 GDNGLIPQRKSRTPENQ-QFPDNESEEYHRICELLSDYKE--------------KQMPKY 486
Query: 1313 EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRK 1372
N +L +E+ ++L + QE + N + +RE+ F + +M +
Sbjct: 487 SSENSN-PEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKH 545
Query: 1373 KL------NEYENGEFSFHGD-----LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCL 1421
+ NG + +GD + S+ Q +++ + +T C
Sbjct: 546 RSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCE 605
Query: 1422 HLDT---KNQILQEELLSMKTVQKKCEKLQ---KNKKKLEQEVINLRSHIERNMVELGQV 1475
+T ++IL E ++ V+K +L K +K + E LR I +EL +
Sbjct: 606 EQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDILHENSTLREEIAMLRLELDTM 665
Query: 1476 KQYKQEIEERARQEIAEKLKEVNLFLQA 1503
K Q E++ ++I K + L+A
Sbjct: 666 KHQSQLREKKYLEDIESVKKRNDNLLKA 693
Score = 34.7 bits (78), Expect = 0.82
Identities = 77/433 (17%), Positives = 173/433 (39%), Gaps = 72/433 (16%)
Query: 729 QDAALSCERLLELKKNH---CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWE 785
QD + R + +H C+LL+ +K K++ + ++ S+ E Q+ +
Sbjct: 334 QDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGS 393
Query: 786 RELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELR 845
S ++QE E ++ D ++ E++++ E V + + L +
Sbjct: 394 EN--SQPEKMSQEPEINKDGD---REVEEEMKKHESN---NVGLLENLTNGV-------- 437
Query: 846 TVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 905
T + N ++ +R + + + + + LS KE +M K +SENS+ +
Sbjct: 438 TAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMP--KYSSENSNPEQ 495
Query: 906 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ-----KTI 960
+ K S + S +K + +K ++ +I K+ + +L+ + +
Sbjct: 496 DLKLTSEEESQ-------------RLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEM 542
Query: 961 KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
K++ T + ++ ++ + +S++ + E E YHS
Sbjct: 543 KKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSD-------- 594
Query: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNS-LEIE 1079
+Q++T K+ E + N + L D I ++ + K+NS L +
Sbjct: 595 EQNDTQKQFCE---------------EQNTGI--LHDEILIHEEKQIEVVEKMNSELSLS 637
Query: 1080 FHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQL 1139
+D L E + ++++++ + ++ M+ + Q++ KY+ ESV++R L
Sbjct: 638 CKKEKDILHENST----LREEIAMLRLELDTMKHQ---SQLREKKYLEDIESVKKRNDNL 690
Query: 1140 QSENMLLRQQLDD 1152
L +DD
Sbjct: 691 LKALQLNELTMDD 703
>gi|239747898 PREDICTED: actin, beta-like 3 [Homo sapiens]
Length = 924
Score = 236 bits (603), Expect = 1e-61
Identities = 139/299 (46%), Positives = 184/299 (61%), Gaps = 53/299 (17%)
Query: 21 RSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMN 80
+S+ G G+ + A+ P YHV DL K+H+AA G V + I++LR +N RDK
Sbjct: 77 KSNVGAWGDYDDSAFMDPRYHVHGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKRDKQK 136
Query: 81 RTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPN 140
RTALHLA ANG+ EVV L++DR+CQLNV DN+ RTAL KAVQCQE++CA +LLEHG DPN
Sbjct: 137 RTALHLASANGNSEVVKLVLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPN 196
Query: 141 LADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
+ D +GNT LHYAVYNED +A LLLY A+IE+KNK LTPLLL + +KQQ+V+FLIK
Sbjct: 197 IPDEYGNTTLHYAVYNEDKLMAKALLLYGADIESKNKHGLTPLLLGIHEQKQQVVKFLIK 256
Query: 201 KKANVNAVDK---------------------LE-------------------SSH----- 215
KKAN+NA+D+ LE SSH
Sbjct: 257 KKANLNALDRYGRTALILAVCCGSASIVSPLLEQNVDVSSQDXGKTAREYAVSSHHHVIC 316
Query: 216 QLISEYKEERIPKHSSQNSNSVDE---SSEDSLSRLSGKPGVDDSWP--TSDDEDLNFD 269
QL+S+YKE+++ K SS+NSN + +SE+ RL G ++S P S + ++N D
Sbjct: 317 QLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKGS---ENSQPEKMSQEPEINKD 372
Score = 108 bits (271), Expect = 3e-23
Identities = 58/114 (50%), Positives = 87/114 (76%), Gaps = 6/114 (5%)
Query: 857 ERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN---SHSHEEEKDLSHK 913
E+ND Q+QLS EQN +LQD IL + ++K+IE+A+KKMNS S S+++EKD H+
Sbjct: 440 EQNDTQKQLSEEQNTGILQDEILXH---EEKQIEVAEKKMNSGPGTLSLSYKKEKDFLHE 496
Query: 914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETL 967
NS LQEE+AMLRLE+D +K+Q+Q +EKK E+++ V++KN++L K ++ NE T+
Sbjct: 497 NSTLQEEVAMLRLELDIMKHQSQLREKKYLEEIESVEKKNDNLLKALQLNELTM 550
Score = 60.8 bits (146), Expect = 1e-08
Identities = 40/105 (38%), Positives = 54/105 (51%), Gaps = 26/105 (24%)
Query: 523 EHDLEVASEEEQER-EGSENNQPQ---------------------VEEERKKHRNNEMEV 560
E DL++ SEEE +R +GSEN+QP+ +EEE KKH + +
Sbjct: 338 EQDLKLTSEEESQRLKGSENSQPEKMSQEPEINKDGDRELEDFMAIEEEMKKHGSTHVGF 397
Query: 561 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYAS 605
N+ +GA + DDGLI RKS + QQFP EN+EY S
Sbjct: 398 PENLTNGAAAG----NGDDGLIPPRKSRTPESQQFPDTENEEYHS 438
Score = 41.6 bits (96), Expect = 0.007
Identities = 63/285 (22%), Positives = 125/285 (43%), Gaps = 56/285 (19%)
Query: 878 ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQ 934
++ LS KE +M K++SENS+ ++ K S + S E ++ + N+
Sbjct: 314 VICQLLSDYKEKQML--KISSENSNPEQDLKLTSEEESQRLKGSENSQPEKMSQEPEINK 371
Query: 935 NQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN 994
+ ++E ED ++E+ + T E LT + NG ++ ++ +
Sbjct: 372 DGDRE---LEDFMAIEEEMKKHGSTHVGFPENLTNGAAAGNG-------DDGLIPPRKSR 421
Query: 995 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSN 1054
+S++ + E E YHS +Q++T K+ L ++ N +
Sbjct: 422 TPESQQFPDTENEEYHSD--------EQNDTQKQ---------------LSEEQNTGI-- 456
Query: 1055 LKDNNEIL---SQQLFKTESKLNS----LEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1107
L+D EIL +Q+ E K+NS L + + +D L E + +Q++++ + +
Sbjct: 457 LQD--EILXHEEKQIEVAEKKMNSGPGTLSLSYKKEKDFLHENST----LQEEVAMLRLE 510
Query: 1108 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDD 1152
+ M+ + Q++ KY+ + ESVE++ L L +DD
Sbjct: 511 LDIMKHQ---SQLREKKYLEEIESVEKKNDNLLKALQLNELTMDD 552
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,940,023
Number of Sequences: 37866
Number of extensions: 2865990
Number of successful extensions: 43033
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 858
Number of HSP's successfully gapped in prelim test: 1531
Number of HSP's that attempted gapping in prelim test: 14164
Number of HSP's gapped (non-prelim): 13387
length of query: 1710
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1594
effective length of database: 13,855,062
effective search space: 22084968828
effective search space used: 22084968828
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.