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Search of human proteins with 154091020
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154091020 leucine-rich repeats and calponin homology (CH)
domain containing 2 [Homo sapiens]
(765 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 1546 0.0
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 547 e-155
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 426 e-119
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 302 7e-82
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 103 5e-22
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 101 2e-21
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 97 6e-20
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 97 7e-20
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 96 1e-19
gi|53729363 leucine rich repeat and sterile alpha motif containi... 94 4e-19
gi|53729361 leucine rich repeat and sterile alpha motif containi... 94 4e-19
gi|53729359 leucine rich repeat and sterile alpha motif containi... 94 4e-19
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 94 4e-19
gi|45827729 scribble isoform b [Homo sapiens] 93 1e-18
gi|45827731 scribble isoform a [Homo sapiens] 93 1e-18
gi|238908508 leucine-rich repeat and death domain-containing pro... 92 1e-18
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 90 9e-18
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 90 9e-18
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 89 1e-17
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 89 1e-17
gi|61742786 leucine rich repeat and death domain containing prot... 89 2e-17
gi|61742784 leucine rich repeat and death domain containing prot... 89 2e-17
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 89 2e-17
gi|4503743 flightless I homolog [Homo sapiens] 88 3e-17
gi|197333706 leucine rich repeat containing 8 family, member D [... 88 3e-17
gi|34222199 leucine rich repeat containing 8 family, member D [H... 88 3e-17
gi|61742782 leucine rich repeat and death domain containing prot... 88 3e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 87 6e-17
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 86 2e-16
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 84 4e-16
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 1546 bits (4004), Expect = 0.0
Identities = 765/765 (100%), Positives = 765/765 (100%)
Query: 1 MAASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPF 60
MAASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPF
Sbjct: 1 MAASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPF 60
Query: 61 PNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSR 120
PNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSR
Sbjct: 61 PNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSR 120
Query: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP
Sbjct: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
Query: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL
Sbjct: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
Query: 241 PDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY 300
PDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY
Sbjct: 241 PDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY 300
Query: 301 LNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLST 360
LNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLST
Sbjct: 301 LNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLST 360
Query: 361 TEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQG 420
TEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQG
Sbjct: 361 TEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQG 420
Query: 421 NAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQL 480
NAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQL
Sbjct: 421 NAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQL 480
Query: 481 LQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPW 540
LQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPW
Sbjct: 481 LQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPW 540
Query: 541 PESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYD 600
PESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYD
Sbjct: 541 PESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYD 600
Query: 601 RTDGFSHSPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRL 660
RTDGFSHSPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRL
Sbjct: 601 RTDGFSHSPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRL 660
Query: 661 KVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACK 720
KVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACK
Sbjct: 661 KVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACK 720
Query: 721 KLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSVA 765
KLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSVA
Sbjct: 721 KLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSVA 765
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 547 bits (1410), Expect = e-155
Identities = 340/721 (47%), Positives = 426/721 (59%), Gaps = 102/721 (14%)
Query: 30 GGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGSLQPQHTVRSLDRALEEAGS 89
G GGAGGGGGG GG F P G L+RALEEA +
Sbjct: 40 GAPGGAGGGGGGSGG-----------FNLPLNRG----------------LERALEEAAN 72
Query: 90 SGILSLSGRKLRDFPGS---GYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCI 146
SG L+LS RKL++FP + G+DL+DT QADLS+NR E+P ++ F LE LNLYHNCI
Sbjct: 73 SGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCI 132
Query: 147 KTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLME 206
+ IPEAI NLQMLTYLN+SRN LS LP L LPLKVL+ SNNKL S+PEEIG+LK LME
Sbjct: 133 RVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLME 192
Query: 207 LDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCY 266
LD+SCNEI LPQQ+G+L SLRELN+RRN L VLP EL DLPLVK DFSCNKV IP+C+
Sbjct: 193 LDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICF 252
Query: 267 RKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMP 326
R++ LQV++L+NNPLQ PPAQIC KGKVHIFKYL+IQAC K DSL L ++ +
Sbjct: 253 REMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQAC--QIKTADSLYLHTMERPHL 310
Query: 327 SQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTVSLHSQVSE-SNREQTSR 385
Q + D +D DSG+GSDNG+KRLS TEPSD+DTVSL+ +S EQ +
Sbjct: 311 HQHVEDGKKD--------SDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIK 362
Query: 386 NDSHIIGSKTDSQKDQE-------VYDFVDPNTEDVAVPEQGNAHIGSFVSFFKGKEKCS 438
DS S + QE + D + E ++ + F+++ E C
Sbjct: 363 EDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCE 422
Query: 439 EKSRKNEELGDEKRLEKEQLL--AEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSV 496
E R E++ + E ++ ++++D D+ + LR+ A LLQ SV
Sbjct: 423 ELLRIEEDV----HWQTEGIISSSKDQDMDIAMIEQLRE-AVDLLQDPNGLSTDITERSV 477
Query: 497 MRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRS 556
+ P + E LE Q ++ Q E+ P+
Sbjct: 478 LNLYPMGSAEA--------------------LELQDSALNGQIQLETSPVC--------- 508
Query: 557 KQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYDRTDGFSHSPFGLKPRS 616
++ + N Q S N + SP S + T +PFGLKPRS
Sbjct: 509 -----------EVQSDLTLQSNGSQYSPN-EIRENSPAVSPTTNST-----APFGLKPRS 551
Query: 617 AFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGV 676
F R R + DP FT+RRKME +REE+E + QLR ++E RLKV L +D+GAALMDGV
Sbjct: 552 VFLRPQR-NLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGV 610
Query: 677 VLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHIL 736
VLCHL NHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFL+AC+KLGV + LC P IL
Sbjct: 611 VLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDIL 670
Query: 737 E 737
+
Sbjct: 671 Q 671
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 426 bits (1095), Expect = e-119
Identities = 287/696 (41%), Positives = 388/696 (55%), Gaps = 80/696 (11%)
Query: 63 GPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP--GSGYDLTDTTQADLSR 120
GP + PGS RSLDRALEEA +G+LSLSGRKLR+FP + +DLTDTT+ADLSR
Sbjct: 37 GPGFGPGSWS-----RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSR 91
Query: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
NR +EIP + F LE LNLY NCI+ IPEAI NLQ LT+LNISRN LSTLP +L +LP
Sbjct: 92 NRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP 151
Query: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
LKVL+ SNNKLVS+PEEIG L+ LMELD+SCNEIQ +P Q+G L +LR+LN+RRN+L L
Sbjct: 152 LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHL 211
Query: 241 PDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY 300
P+EL +LPL++LDFSCNK+T IPVCYR L HLQ I LDNNPLQ PPAQIC+KGKVHIFKY
Sbjct: 212 PEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKY 271
Query: 301 LNIQACCRMDKKPDSLDLPSLSKRMPSQPL--TDSMEDFYPNKNHGP-DSGIGS-DNGEK 356
LNIQAC + DLP +R PL E+ Y ++ +G DSG S D+G+K
Sbjct: 272 LNIQAC------KIAPDLPDYDRR----PLGFGSCHEELYSSRPYGALDSGFNSVDSGDK 321
Query: 357 RLSTTEPSDDDTVSLHSQVSESNREQTSRNDSH-------IIGSKTDSQKDQEVYDFVDP 409
R S EP+D+ + L +V+E +EQ R +S ++ + + D + D++D
Sbjct: 322 RWSGNEPTDEFS-DLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDS 380
Query: 410 NT---EDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDD 466
T E+ V + S S F E+ R + E K + + ++ +D
Sbjct: 381 CTAEEEEAEVRQPKGPDPDSLSSQFMA---YIEQRRISHEGSPVKPVAIREF---QKTED 434
Query: 467 LKEVTDLRKIAAQ---LLQQEQKNRILNHSTSVMRNKPKQTVECEK------SVSADEVN 517
++ ++ A+ LL + L+H+ + + +Q VE + ++ +E
Sbjct: 435 MRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEK 494
Query: 518 SPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNE 577
+ + + Q Q + HP++ + R ++ ++ S SG
Sbjct: 495 IRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLN 554
Query: 578 NDEQDSDNANMSTQSPVSSEEYDR-------TDGFSHSPF-----------GLKPRSAFS 619
+ + S +P+ S++ T+ HSP +P S
Sbjct: 555 QVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLF 614
Query: 620 RS---SRQEYGAADP------------GFTMRRKMEHLREEREQIRQLRNNLESRLKVIL 664
R+ + G A P + EE E I QLR ++E RLKV L
Sbjct: 615 RAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSL 674
Query: 665 PDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAV 700
P D+GAAL DGVVLCHLANH+RPRSV SIHVPSPAV
Sbjct: 675 PCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 302 bits (774), Expect = 7e-82
Identities = 189/416 (45%), Positives = 249/416 (59%), Gaps = 38/416 (9%)
Query: 63 GPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP---GSGYDLTDTTQADLS 119
G P PG RS +RALEEA ++G L+LS R+L+ FP YDL+D TQADLS
Sbjct: 24 GSPGLPGR-------RSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLS 76
Query: 120 RNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
RNRF E+P LE L+LYHNC++ + A+ NL LTYLN+SRN LS LP Y+ L
Sbjct: 77 RNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL 136
Query: 180 PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHV 239
PL+VL+VSNNKL ++P +IG L L +LD+S NE+Q LP ++ L SLR+LN+RRN L
Sbjct: 137 PLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLST 196
Query: 240 LPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFK 299
LP+ELGDLPLV+LDFSCN+V+ IPV + +L HLQVI+LD+NPLQ PPAQ+CLKGK+HIFK
Sbjct: 197 LPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
Query: 300 YLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDS---MEDFYPNKNH--GPDSGIGS-DN 353
YL+ +A R +L PS+P + S ED +P + G DSG S D+
Sbjct: 257 YLSTEAGQRGS---------ALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDS 307
Query: 354 GEKRLSTTEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNT-- 411
G KR S E S D+ L ++SE RE + GS + D DF+D +
Sbjct: 308 GSKRWSGNE-STDEFSELSFRISELAREPRGPRERKEDGS---ADGDPVQIDFIDSHVPG 363
Query: 412 ---EDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEED 464
E V EQ + S G + + SR+ E G+E+R L +E +
Sbjct: 364 EDEERGTVEEQRPPEL----SPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERE 415
Score = 121 bits (304), Expect = 2e-27
Identities = 67/133 (50%), Positives = 89/133 (66%), Gaps = 4/133 (3%)
Query: 613 KPRSAFSRSSRQE-YGAADPGFTMR-RKMEHLREEREQIRQLRNNLESRLKVILPDDIGA 670
+P S RSS Q G + P +R R+ + +E++ + QLR LESRL+ LP+D+
Sbjct: 503 RPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAE 562
Query: 671 ALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLC 730
AL GV+LC LAN +RPRSV IHVPSPAVPKLS K R+NVE+FL+AC+K+GV + LC
Sbjct: 563 ALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLC 622
Query: 731 LPHHILE--ERGL 741
P +L+ RGL
Sbjct: 623 SPSDLLQGTARGL 635
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 103 bits (258), Expect = 5e-22
Identities = 69/254 (27%), Positives = 123/254 (48%), Gaps = 27/254 (10%)
Query: 61 PNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSR 120
PN P ++ L++ EE +S L LS R + P S +LT T+ L
Sbjct: 75 PNPAPGTRKKSSNAEVIKELNKCREE--NSMRLDLSKRSIHILPSSIKELTQLTELYLYS 132
Query: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
N+ +P++V L TL L N + ++P+++ NL+ L L++ N L +P ++ L
Sbjct: 133 NKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLD 192
Query: 181 ------------------------LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQV 216
L +L + NK+ +P EIG+L +L+ LD++ N+++
Sbjct: 193 SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEH 252
Query: 217 LPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVI 275
LP+++G + L+++ N L LPD +G+L L +L N+++ IP K L+ +
Sbjct: 253 LPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEEL 312
Query: 276 ILDNNPLQVPPAQI 289
L+NN + P +
Sbjct: 313 NLENNNISTLPESL 326
Score = 95.5 bits (236), Expect = 2e-19
Identities = 70/216 (32%), Positives = 108/216 (50%), Gaps = 28/216 (12%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L++ +L P T + +L+ N+ T+IP DV LE L L +N +K +P
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHG 443
Query: 153 IKNLQMLTYLNISRNLLSTLPK---YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDI 209
+ NL+ L L++ N L +LP YL D L+ LV++NN+L ++P IG L +L L +
Sbjct: 444 LGNLRKLRELDLEENKLESLPNEIAYLKD--LQKLVLTNNQLTTLPRGIGHLTNLTHLGL 501
Query: 210 SCNEIQVLPQQMGKLHSLRELNIRRN-NLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRK 268
N + LP+++G L +L EL + N NLH LP EL C+K
Sbjct: 502 GENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELA---------LCSK---------- 542
Query: 269 LHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQ 304
L ++ ++N PL P QI G I ++L +Q
Sbjct: 543 ---LSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQ 575
Score = 84.0 bits (206), Expect = 5e-16
Identities = 58/190 (30%), Positives = 100/190 (52%), Gaps = 4/190 (2%)
Query: 117 DLSRNRFTEIPSDVWLFAP-LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKY 175
++ NR +IP ++ A L LN+ N + ++P + LN++ N L+ +P+
Sbjct: 361 NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED 420
Query: 176 LFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
+ L L+VL++SNN L +P +G L+ L ELD+ N+++ LP ++ L L++L +
Sbjct: 421 VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Query: 235 NNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNP-LQVPPAQICLK 292
N L LP +G L L L N +T +P L +L+ + L++NP L P ++ L
Sbjct: 481 NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC 540
Query: 293 GKVHIFKYLN 302
K+ I N
Sbjct: 541 SKLSIMSIEN 550
Score = 75.9 bits (185), Expect = 1e-13
Identities = 63/267 (23%), Positives = 108/267 (40%), Gaps = 51/267 (19%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ ++ L + E + L ++ +L P + T T DL N ++P +
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKV---------- 183
+ L L L +N + IP ++ L LN+ N +STLP+ L +K+
Sbjct: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
Query: 184 ----------------------------------------LVVSNNKLVSIPEEIGKLKD 203
L + +N+L S+P + G
Sbjct: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS 403
Query: 204 LMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEI 262
++EL+++ N++ +P+ + L SL L + N L LP LG+L L +LD NK+ +
Sbjct: 404 MVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Query: 263 PVCYRKLHHLQVIILDNNPLQVPPAQI 289
P L LQ ++L NN L P I
Sbjct: 464 PNEIAYLKDLQKLVLTNNQLTTLPRGI 490
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 101 bits (252), Expect = 2e-21
Identities = 73/244 (29%), Positives = 113/244 (46%), Gaps = 54/244 (22%)
Query: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
+ + G S +L ++G + L+ TQ LS N+ T +P ++ LE LN ++
Sbjct: 22 MSDRGISNMLDVNGL---------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFN 72
Query: 144 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP----------------------- 180
N I+ +P I +LQ L +LN+ N L+TLP+ LP
Sbjct: 73 NQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY 132
Query: 181 ---LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNL 237
L+ L +S+N +P +IGKL L L + N++ LP+++G+L L+EL+I+ N L
Sbjct: 133 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 192
Query: 238 HVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
VLP ELG+L L QV +NNP P A G H+
Sbjct: 193 TVLPPELGNLDLT-------------------GQKQVFKAENNPWVTPIADQFQLGVSHV 233
Query: 298 FKYL 301
F+Y+
Sbjct: 234 FEYI 237
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 97.1 bits (240), Expect = 6e-20
Identities = 69/228 (30%), Positives = 111/228 (48%), Gaps = 25/228 (10%)
Query: 84 LEEAGSSGILSLSGRKLRDFPGS-----------------------GYDLTDTTQADLSR 120
L+ A SG L+LSGR L + P ++ TD T+ +S
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISN 91
Query: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL- 179
N+ + D+ L L L+++ N + ++P AI+ L+ L LN+S N L LP+ + +L
Sbjct: 92 NKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLR 151
Query: 180 PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHV 239
LK L + +N+L I E +L +L +LD+S N + +P L SL LN+ N L
Sbjct: 152 NLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKS 211
Query: 240 LPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPP 286
LP E+ + +K LD + N + IP + L+++ L N L+ P
Sbjct: 212 LPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Score = 93.6 bits (231), Expect = 6e-19
Identities = 65/195 (33%), Positives = 106/195 (54%), Gaps = 5/195 (2%)
Query: 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLL 169
L++ DLS N T +P+ + L LNL N +K++P I ++ L +L+ + NLL
Sbjct: 173 LSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLL 232
Query: 170 STLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVL-PQQMGKLHSL 227
T+P L + L++L + NKL +P E L EL + N+I++L + + L+S+
Sbjct: 233 ETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSI 291
Query: 228 RELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPP 286
L++R N L +PDE+ L L +LD S N ++ +P L HL+ + L+ NPL+
Sbjct: 292 LVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIR 350
Query: 287 AQICLKGKVHIFKYL 301
+I KG + KYL
Sbjct: 351 REIISKGTQEVLKYL 365
Score = 74.7 bits (182), Expect = 3e-13
Identities = 61/216 (28%), Positives = 107/216 (49%), Gaps = 28/216 (12%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDT---TQADLSRNRFTEIPSD-VWLFAPLETLNLYHNCIK 147
IL S ++ P +D + T + S+N+ EIP V L + ++L N +
Sbjct: 403 ILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLS 462
Query: 148 TIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLME 206
I + LQ LT+L++ N L++LP+ + L L+ + +S N+ +PE + ++ L
Sbjct: 463 FISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLET 522
Query: 207 LDISCNEI-QVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVC 265
+ IS N++ V PQ+M + +L L+++ N+L +P ELG+
Sbjct: 523 ILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV----------------- 565
Query: 266 YRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYL 301
+L+ ++LD NP +VP A I +KG I +YL
Sbjct: 566 -----NLRTLLLDGNPFRVPRAAILMKGTAAILEYL 596
Score = 67.8 bits (164), Expect = 4e-11
Identities = 45/151 (29%), Positives = 81/151 (53%), Gaps = 2/151 (1%)
Query: 139 LNLYHNCIKTIPEAIKNLQMLTYLNISRNL-LSTLPKYLFDLPLKVLVVSNNKLVSIPEE 197
LNL + +P+ + + + ++NL ++ L L++SNNKL S+ ++
Sbjct: 41 LNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDD 100
Query: 198 IGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSC 256
+ L L LDI N++ LP + +L +L++LN+ N L +LP+E+ +L +K L
Sbjct: 101 LRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQH 160
Query: 257 NKVTEIPVCYRKLHHLQVIILDNNPLQVPPA 287
N++T I + +L +L+ + L NN L PA
Sbjct: 161 NELTCISEGFEQLSNLEDLDLSNNHLTTVPA 191
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 96.7 bits (239), Expect = 7e-20
Identities = 68/215 (31%), Positives = 105/215 (48%), Gaps = 5/215 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+L L L GS L + DLS+N P + LE L L N I +P
Sbjct: 284 LLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPS 343
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNN---KLVSIPEEIGKLKDLMEL 207
+ +L L L ++ N + P+ + L L+ L + + KL +PE I KL+ L EL
Sbjct: 344 ELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKEL 403
Query: 208 DISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCY 266
I N ++ LP +G + +L L+ R N L LPD + +K L N +T +P
Sbjct: 404 YIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
Query: 267 RKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYL 301
L +L+V+ L +NP++ PP ++C +G I+KYL
Sbjct: 464 DSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYL 498
Score = 81.3 bits (199), Expect = 3e-15
Identities = 68/234 (29%), Positives = 113/234 (48%), Gaps = 5/234 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+L L+G L+ P + T + L RN+F P ++ + LE ++L N I IPE
Sbjct: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
I +L L ++ N L LP L L VL +S+N L SIP+ +L+ + E+ +S
Sbjct: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLS 265
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKL 269
N ++ +P+ + + SL L + LH L L ++ LD S N + P+ L
Sbjct: 266 GNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICAL 325
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSK 323
+L+V+ LD+N + P+++ G + K L + + + L L SL K
Sbjct: 326 KNLEVLGLDDNKIGQLPSEL---GSLSKLKILGLTGNEFLSFPEEVLSLASLEK 376
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/180 (28%), Positives = 85/180 (47%), Gaps = 25/180 (13%)
Query: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSI 194
LE L L N +K +P+ I N L + + RN P+ L L L+++ + NK+ +I
Sbjct: 144 LELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAI 203
Query: 195 PEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLD 253
PEEIG L L + ++ N + VLP + + L L++ N LH +P +L + ++
Sbjct: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 254 FSCNKVTEIP--VC---------------------YRKLHHLQVIILDNNPLQVPPAQIC 290
S N++ ++P +C +R L +L+ + L N L P QIC
Sbjct: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/202 (29%), Positives = 94/202 (46%), Gaps = 4/202 (1%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
+ S + L P + T+ + L N+ EIP ++ + L L N ++++ A
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 153 IKNLQMLTYLNISRNLL--STLPKYLFDLPLKVLVVSNNKLVSIPEEIGK-LKDLMELDI 209
+ L L L++S N + S+L F L+ L + L IP I K L L L +
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRK 268
+ N ++ LP+++ LRE+ ++RN V P EL L L +D NK+ IP
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
Query: 269 LHHLQVIILDNNPLQVPPAQIC 290
L LQ + +N L V PA +C
Sbjct: 210 LTGLQKFYMASNNLPVLPASLC 231
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 26/135 (19%)
Query: 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD 246
SN L +IP EI +L E+ + N+I+ +PQ++ +L ++R L + +NNL L LG
Sbjct: 33 SNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL 92
Query: 247 L-PLVKLDFSCNKV------------------------TEIP-VCYRKLHHLQVIILDNN 280
L L LD S N + EIP V ++ LHHL+++ L N
Sbjct: 93 LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
Query: 281 PLQVPPAQICLKGKV 295
L+ P +I + K+
Sbjct: 153 HLKCLPKEIVNQTKL 167
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/220 (31%), Positives = 104/220 (47%), Gaps = 25/220 (11%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
IL L L+ P S + L + DL N F E+P + L L + +N ++ +P
Sbjct: 165 ILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
Query: 152 AIKNLQMLTYLNISRNLLSTLP----------------KYLFDLP--------LKVLVVS 187
+I L+ML YL++S+N + T+ L LP L L V
Sbjct: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVD 284
Query: 188 NNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL 247
+N+L +P IG L L E D SCNE++ LP +G LHSLR L + N L LP E+G
Sbjct: 285 DNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSC 344
Query: 248 PLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPP 286
V + NK+ +P ++ L+V+ L +N L+ P
Sbjct: 345 KNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 89.0 bits (219), Expect = 2e-17
Identities = 60/203 (29%), Positives = 104/203 (51%), Gaps = 2/203 (0%)
Query: 80 LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETL 139
L L++ + L + L+ PGS L D+S+NR + D+ LE L
Sbjct: 199 LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDL 258
Query: 140 NLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEI 198
L N ++ +P++I L+ LT L + N L+ LP + +L L+ S N+L S+P I
Sbjct: 259 LLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTI 318
Query: 199 GKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCN 257
G L L L + N + LP+++G ++ +++R N L LP+E+G + ++ L+ S N
Sbjct: 319 GYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDN 378
Query: 258 KVTEIPVCYRKLHHLQVIILDNN 280
++ +P + KL L + L +N
Sbjct: 379 RLKNLPFSFTKLKELAALWLSDN 401
Score = 86.7 bits (213), Expect = 8e-17
Identities = 66/223 (29%), Positives = 102/223 (45%), Gaps = 25/223 (11%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
I+ S + P L + TQ L+ +P++ L L L N +KT+P+
Sbjct: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
++ L L L++ N LP+ L + L+ L + NN L +P IGKLK L+ LD+S
Sbjct: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
Query: 211 CNEI-----------------------QVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL 247
N I Q LP +G L L L + N L +LP+ +G+L
Sbjct: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNL 298
Query: 248 PLV-KLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
L+ + D SCN++ +P LH L+ + +D N L P +I
Sbjct: 299 SLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREI 341
Score = 86.3 bits (212), Expect = 1e-16
Identities = 63/209 (30%), Positives = 101/209 (48%), Gaps = 2/209 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
LS+ L + P + L + + D+S+N E P ++ L + N I +P+
Sbjct: 74 LSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDG 133
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
L LT L ++ L LP L L++L + N L ++P+ + KL L LD+
Sbjct: 134 FTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLH 270
NE LP+ + ++ +LREL + N L VLP +G L LV LD S N++ + +
Sbjct: 194 NEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCE 253
Query: 271 HLQVIILDNNPLQVPPAQICLKGKVHIFK 299
L+ ++L +N LQ P I L K+ K
Sbjct: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Score = 69.3 bits (168), Expect = 1e-11
Identities = 59/217 (27%), Positives = 94/217 (43%), Gaps = 52/217 (23%)
Query: 136 LETLNLYHNCIKTIPEAIKNLQM-LTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVS 193
+ L+ H ++ +P+ + N + L L + N + LPK LF+ L+ L + +N L +
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 194 IPEEIGKLKDLMELDISCNEIQ-------------------------------------- 215
+P I L +L ELDIS N +Q
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 216 --------VLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCY 266
LP G+L LR L +R N+L LP + L L +LD N+ E+P
Sbjct: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVL 203
Query: 267 RKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNI 303
++ +L+ + +DNN LQV P I GK+ + YL++
Sbjct: 204 DQIQNLRELWMDNNALQVLPGSI---GKLKMLVYLDM 237
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/168 (26%), Positives = 80/168 (47%), Gaps = 1/168 (0%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ + ++D + + L LS L+ P S L T + N+ T +P+ +
Sbjct: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNL 298
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV 192
+ LE + N ++++P I L L L + N L LP+ + + V+ + +NKL
Sbjct: 299 SLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE 358
Query: 193 SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
+PEEIG+++ L L++S N ++ LP KL L L + N L
Sbjct: 359 FLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 94.4 bits (233), Expect = 4e-19
Identities = 103/413 (24%), Positives = 180/413 (43%), Gaps = 58/413 (14%)
Query: 154 KNLQMLTYLNISRNLLSTLPKYLFDLPL---KVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
K LQ + + +L S LPK L L KVL + +N+L ++P+++G+L L L++
Sbjct: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKL 269
N++ LP+ +G L L+ LN++ N L LPD +G+L L L+ S N++ +P +
Sbjct: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQP 329
L+++ LD + + PP ++C G I ++L C+ L PSQ
Sbjct: 173 RTLEMLSLDASAMVYPPREVCGAGTAAILQFL-----CKES---------GLEYYPPSQY 218
Query: 330 LTDSME-DFYPNKNHGPDSGIGSDNGEK-----RLSTTEPSDDDTVSLHSQVSESNREQT 383
L +E D N PD + E+ R S E + + L E E
Sbjct: 219 LLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM-LEKLEFERRLELG 277
Query: 384 SRNDSHIIGSKTDSQKDQEVYDFVDPNT---------------------EDVAVPEQG-N 421
R + ++ ++ SQKD+ + + + E + EQ +
Sbjct: 278 QREHTQLL-QQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNIS 336
Query: 422 AHIGSFVSFFKGKEKCSE--KSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQ 479
+ I + + ++K SE KS +NE + R+E+ + +EE + L+ D+ Q
Sbjct: 337 SRIQKLLQDNQRQKKSSEILKSLENERI----RMEQLMSITQEETESLRR-RDVASAMQQ 391
Query: 480 LLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQK 532
+L + KNR++ + R Q C DE + L+WQ ++ K
Sbjct: 392 MLTESCKNRLIQMAYESQRQNLVQQA-CSSMAEMDERFQQI--LSWQQMDQNK 441
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+L L +L P LT ++ RN+ ++P + L+TLN+ N +K +P+
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
+ L+ L LNIS N + LP+ L + L++L + + +V P E+ L
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 211 CNE 213
C E
Sbjct: 205 CKE 207
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 94.4 bits (233), Expect = 4e-19
Identities = 103/413 (24%), Positives = 180/413 (43%), Gaps = 58/413 (14%)
Query: 154 KNLQMLTYLNISRNLLSTLPKYLFDLPL---KVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
K LQ + + +L S LPK L L KVL + +N+L ++P+++G+L L L++
Sbjct: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKL 269
N++ LP+ +G L L+ LN++ N L LPD +G+L L L+ S N++ +P +
Sbjct: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQP 329
L+++ LD + + PP ++C G I ++L C+ L PSQ
Sbjct: 173 RTLEMLSLDASAMVYPPREVCGAGTAAILQFL-----CKES---------GLEYYPPSQY 218
Query: 330 LTDSME-DFYPNKNHGPDSGIGSDNGEK-----RLSTTEPSDDDTVSLHSQVSESNREQT 383
L +E D N PD + E+ R S E + + L E E
Sbjct: 219 LLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM-LEKLEFERRLELG 277
Query: 384 SRNDSHIIGSKTDSQKDQEVYDFVDPNT---------------------EDVAVPEQG-N 421
R + ++ ++ SQKD+ + + + E + EQ +
Sbjct: 278 QREHTQLL-QQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNIS 336
Query: 422 AHIGSFVSFFKGKEKCSE--KSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQ 479
+ I + + ++K SE KS +NE + R+E+ + +EE + L+ D+ Q
Sbjct: 337 SRIQKLLQDNQRQKKSSEILKSLENERI----RMEQLMSITQEETESLRR-RDVASAMQQ 391
Query: 480 LLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQK 532
+L + KNR++ + R Q C DE + L+WQ ++ K
Sbjct: 392 MLTESCKNRLIQMAYESQRQNLVQQA-CSSMAEMDERFQQI--LSWQQMDQNK 441
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+L L +L P LT ++ RN+ ++P + L+TLN+ N +K +P+
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
+ L+ L LNIS N + LP+ L + L++L + + +V P E+ L
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 211 CNE 213
C E
Sbjct: 205 CKE 207
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 94.4 bits (233), Expect = 4e-19
Identities = 103/413 (24%), Positives = 180/413 (43%), Gaps = 58/413 (14%)
Query: 154 KNLQMLTYLNISRNLLSTLPKYLFDLPL---KVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
K LQ + + +L S LPK L L KVL + +N+L ++P+++G+L L L++
Sbjct: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKL 269
N++ LP+ +G L L+ LN++ N L LPD +G+L L L+ S N++ +P +
Sbjct: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQP 329
L+++ LD + + PP ++C G I ++L C+ L PSQ
Sbjct: 173 RTLEMLSLDASAMVYPPREVCGAGTAAILQFL-----CKES---------GLEYYPPSQY 218
Query: 330 LTDSME-DFYPNKNHGPDSGIGSDNGEK-----RLSTTEPSDDDTVSLHSQVSESNREQT 383
L +E D N PD + E+ R S E + + L E E
Sbjct: 219 LLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM-LEKLEFERRLELG 277
Query: 384 SRNDSHIIGSKTDSQKDQEVYDFVDPNT---------------------EDVAVPEQG-N 421
R + ++ ++ SQKD+ + + + E + EQ +
Sbjct: 278 QREHTQLL-QQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNIS 336
Query: 422 AHIGSFVSFFKGKEKCSE--KSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQ 479
+ I + + ++K SE KS +NE + R+E+ + +EE + L+ D+ Q
Sbjct: 337 SRIQKLLQDNQRQKKSSEILKSLENERI----RMEQLMSITQEETESLRR-RDVASAMQQ 391
Query: 480 LLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQK 532
+L + KNR++ + R Q C DE + L+WQ ++ K
Sbjct: 392 MLTESCKNRLIQMAYESQRQNLVQQA-CSSMAEMDERFQQI--LSWQQMDQNK 441
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+L L +L P LT ++ RN+ ++P + L+TLN+ N +K +P+
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
+ L+ L LNIS N + LP+ L + L++L + + +V P E+ L
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 211 CNE 213
C E
Sbjct: 205 CKE 207
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 94.4 bits (233), Expect = 4e-19
Identities = 71/216 (32%), Positives = 107/216 (49%), Gaps = 9/216 (4%)
Query: 82 RALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNL 141
R LEE L L ++ + P S L L N+ +E+P ++ L L++
Sbjct: 174 RRLEE------LDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 142 YHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGK 200
N ++ +PE I L LT L IS+NLL T+P + L L +L V N+L +PE +G+
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGE 287
Query: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKV 259
+ L EL ++ N++ LP+ +GKL L LN RN L LP E+G L N++
Sbjct: 288 CESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRL 347
Query: 260 TEIPVCYRKLHHLQVI-ILDNNPLQVPPAQICLKGK 294
T IP + L V+ + N L +P + LK K
Sbjct: 348 TRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLK 383
Score = 94.0 bits (232), Expect = 5e-19
Identities = 69/222 (31%), Positives = 113/222 (50%), Gaps = 7/222 (3%)
Query: 118 LSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL- 176
L N+ E+P + L L L N I+ +P I N L L++SRN + +P+ +
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 177 FDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
F L+V S N L +PE +L++L L ++ +Q LP+ +G L++L L +R N
Sbjct: 103 FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENL 162
Query: 237 LHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKV 295
L LPD L L L +LD N++ +P L HL+ + LD N L P +I G +
Sbjct: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI---GNL 219
Query: 296 HIFKYLNIQACCRMDKKPDSLD-LPSLSKRMPSQPLTDSMED 336
L++ R+++ P+ + L SL+ + SQ L +++ D
Sbjct: 220 KNLLCLDVSE-NRLERLPEEISGLTSLTDLVISQNLLETIPD 260
Score = 92.8 bits (229), Expect = 1e-18
Identities = 65/209 (31%), Positives = 107/209 (51%), Gaps = 2/209 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L LS +++ P + + D+SRN EIP + L+ + N + +PE+
Sbjct: 64 LGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPES 123
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
LQ LT L+++ L +LP+ + +L L L + N L +P+ + +L+ L ELD+
Sbjct: 124 FPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGN 183
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLH 270
NEI LP+ +G L L++L + N L LP E+G+L L+ LD S N++ +P L
Sbjct: 184 NEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLT 243
Query: 271 HLQVIILDNNPLQVPPAQICLKGKVHIFK 299
L +++ N L+ P I K+ I K
Sbjct: 244 SLTDLVISQNLLETIPDGIGKLKKLSILK 272
Score = 91.3 bits (225), Expect = 3e-18
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 2/224 (0%)
Query: 76 TVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAP 135
+++SL + + L L L P S L + DL N +P +
Sbjct: 139 SLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
Query: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSI 194
L+ L L N + +P+ I NL+ L L++S N L LP+ + L L LV+S N L +I
Sbjct: 199 LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETI 258
Query: 195 PEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLD 253
P+ IGKLK L L + N + LP+ +G+ SL EL + N L LP +G L L L+
Sbjct: 259 PDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLN 318
Query: 254 FSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
NK+ +P L V + +N L PA++ ++H+
Sbjct: 319 ADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHV 362
Score = 90.9 bits (224), Expect = 4e-18
Identities = 64/213 (30%), Positives = 108/213 (50%), Gaps = 5/213 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
+ SG L P S +L + T ++ +P ++ L +L L N + +P+
Sbjct: 109 VADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD 168
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
++ L+ L L++ N + LP+ + L LK L + N+L +P+EIG LK+L+ LD+S
Sbjct: 169 SLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVS 228
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKL 269
N ++ LP+++ L SL +L I +N L +PD +G L L L N++T++P +
Sbjct: 229 ENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLN 302
L ++L N L P I GK+ LN
Sbjct: 289 ESLTELVLTENQLLTLPKSI---GKLKKLSNLN 318
Score = 87.0 bits (214), Expect = 6e-17
Identities = 68/212 (32%), Positives = 106/212 (50%), Gaps = 2/212 (0%)
Query: 80 LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETL 139
L + E + LS++ L+ P + +L + +L N T +P + LE L
Sbjct: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 140 NLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEI 198
+L +N I +PE+I L L L + N LS LP+ + +L L L VS N+L +PEEI
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
Query: 199 GKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCN 257
L L +L IS N ++ +P +GKL L L + +N L LP+ +G+ L +L + N
Sbjct: 240 SGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTEN 299
Query: 258 KVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
++ +P KL L + D N L P +I
Sbjct: 300 QLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
Score = 86.3 bits (212), Expect = 1e-16
Identities = 65/210 (30%), Positives = 106/210 (50%), Gaps = 8/210 (3%)
Query: 82 RALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNL 141
R+LEE L L +LR+ P + L + LS N +P ++ F L L++
Sbjct: 36 RSLEE------LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDV 89
Query: 142 YHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGK 200
N I IPE+I + L + S N L+ LP+ +L L L V++ L S+PE IG
Sbjct: 90 SRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGN 149
Query: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKV 259
L +L L++ N + LP + +L L EL++ N ++ LP+ +G L +K L N++
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209
Query: 260 TEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
+E+P L +L + + N L+ P +I
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEI 239
Score = 70.1 bits (170), Expect = 7e-12
Identities = 53/167 (31%), Positives = 77/167 (46%), Gaps = 1/167 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L +S +L P LT T +S+N IP + L L + N + +PEA
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
+ + LT L ++ N L TLPK + L L L NKLVS+P+EIG L +
Sbjct: 285 VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRD 344
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNK 258
N + +P ++ + L L++ N L LP L L L L S N+
Sbjct: 345 NRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ 391
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/116 (30%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 175 YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
Y + L+ L++ N+L +PE+ +L L +L +S NEIQ LP ++ L EL++ R
Sbjct: 32 YRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSR 91
Query: 235 NNLHVLPDELGDLPLVKL-DFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
N + +P+ + +++ DFS N +T +P + +L +L + +++ LQ P I
Sbjct: 92 NEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENI 147
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 92.8 bits (229), Expect = 1e-18
Identities = 69/216 (31%), Positives = 107/216 (49%), Gaps = 2/216 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L LS +++ P + + D+SRN EIP + LE + N + +P+
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
L+ L +L ++ L LP + +L L L + N L S+P + L L +LD+
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLH 270
N+++VLP +G L +LREL + RN L LP ELG+L LV LD S N++ E+P L
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLV 243
Query: 271 HLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQAC 306
L ++L N L+ P I ++ I K + C
Sbjct: 244 LLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLC 279
Score = 89.7 bits (221), Expect = 9e-18
Identities = 65/215 (30%), Positives = 107/215 (49%), Gaps = 2/215 (0%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ ++SL +L L L G L P + L + + L RN+ + +P ++
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV 192
L L++ N ++ +P + L +LT L +S+NLL LP + L L +L V N+L
Sbjct: 220 RRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLC 279
Query: 193 SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD-LPLVK 251
+ E IG ++L EL ++ N + LP+ +GKL L LN+ RN+L LP E+G + L
Sbjct: 280 EVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSV 339
Query: 252 LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPP 286
L N++ +P L V+ + N LQ P
Sbjct: 340 LSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 74.3 bits (181), Expect = 4e-13
Identities = 52/174 (29%), Positives = 84/174 (48%), Gaps = 2/174 (1%)
Query: 118 LSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL- 176
L N+ E+P + L L L N I+ +P + N L L++SRN + +P+ +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 177 FDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
F L++ S N L +P+ +L+ L L ++ +Q LP +G L +L L +R N
Sbjct: 103 FCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENL 162
Query: 237 LHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
L LP L L L +LD N + +P L +L+ + LD N L P ++
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 63.9 bits (154), Expect = 5e-10
Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 1/161 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L +S +L + P L T LS+N +P + L L + N + + EA
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
I + + L+ L ++ NLL LP+ L L L L V N L ++P EIG L L +
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRD 344
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
N + VLP ++ L L++ N L LP L L L L
Sbjct: 345 NRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKAL 385
Score = 57.4 bits (137), Expect = 5e-08
Identities = 33/116 (28%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 175 YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
Y + L+ L++ N+L +P+ +L +L +L +S NEIQ LP ++ L EL++ R
Sbjct: 32 YRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSR 91
Query: 235 NNLHVLPDELGDLPLVKL-DFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
N++ +P+ + +++ DFS N ++ +P + +L L + L++ LQ P +
Sbjct: 92 NDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDV 147
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/146 (25%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDV 130
L Q+ +R L + + IL + +L + + D + ++ L+ N +P +
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 131 WLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL-FDLPLKVLVVSNN 189
L LN+ N ++ +P I L+ L++ N L+ LP L L VL V+ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 190 KLVSIPEEIGKLKDLMELDISCNEIQ 215
+L S+P + L +L L ++ N+ Q
Sbjct: 369 RLQSLPFALTHL-NLKALWLAENQAQ 393
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 92.8 bits (229), Expect = 1e-18
Identities = 69/216 (31%), Positives = 107/216 (49%), Gaps = 2/216 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L LS +++ P + + D+SRN EIP + LE + N + +P+
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
L+ L +L ++ L LP + +L L L + N L S+P + L L +LD+
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLH 270
N+++VLP +G L +LREL + RN L LP ELG+L LV LD S N++ E+P L
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLV 243
Query: 271 HLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQAC 306
L ++L N L+ P I ++ I K + C
Sbjct: 244 LLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLC 279
Score = 89.7 bits (221), Expect = 9e-18
Identities = 65/215 (30%), Positives = 107/215 (49%), Gaps = 2/215 (0%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ ++SL +L L L G L P + L + + L RN+ + +P ++
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV 192
L L++ N ++ +P + L +LT L +S+NLL LP + L L +L V N+L
Sbjct: 220 RRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLC 279
Query: 193 SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD-LPLVK 251
+ E IG ++L EL ++ N + LP+ +GKL L LN+ RN+L LP E+G + L
Sbjct: 280 EVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSV 339
Query: 252 LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPP 286
L N++ +P L V+ + N LQ P
Sbjct: 340 LSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 74.3 bits (181), Expect = 4e-13
Identities = 52/174 (29%), Positives = 84/174 (48%), Gaps = 2/174 (1%)
Query: 118 LSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL- 176
L N+ E+P + L L L N I+ +P + N L L++SRN + +P+ +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 177 FDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
F L++ S N L +P+ +L+ L L ++ +Q LP +G L +L L +R N
Sbjct: 103 FCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENL 162
Query: 237 LHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
L LP L L L +LD N + +P L +L+ + LD N L P ++
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 63.9 bits (154), Expect = 5e-10
Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 1/161 (0%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L +S +L + P L T LS+N +P + L L + N + + EA
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
I + + L+ L ++ NLL LP+ L L L L V N L ++P EIG L L +
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRD 344
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
N + VLP ++ L L++ N L LP L L L L
Sbjct: 345 NRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKAL 385
Score = 57.4 bits (137), Expect = 5e-08
Identities = 33/116 (28%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 175 YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
Y + L+ L++ N+L +P+ +L +L +L +S NEIQ LP ++ L EL++ R
Sbjct: 32 YRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSR 91
Query: 235 NNLHVLPDELGDLPLVKL-DFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
N++ +P+ + +++ DFS N ++ +P + +L L + L++ LQ P +
Sbjct: 92 NDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDV 147
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/146 (25%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDV 130
L Q+ +R L + + IL + +L + + D + ++ L+ N +P +
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 131 WLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL-FDLPLKVLVVSNN 189
L LN+ N ++ +P I L+ L++ N L+ LP L L VL V+ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 190 KLVSIPEEIGKLKDLMELDISCNEIQ 215
+L S+P + L +L L ++ N+ Q
Sbjct: 369 RLQSLPFALTHL-NLKALWLAENQAQ 393
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 92.4 bits (228), Expect = 1e-18
Identities = 65/207 (31%), Positives = 100/207 (48%), Gaps = 6/207 (2%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L L +++ P S ++ L N+F P ++ L+ L+L N ++ I
Sbjct: 538 LDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSD 597
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP----LKVLVVSNNKLVSIPEEIGKLKDLMELD 208
I NL+ + LN S N P L L L + + KL +P E+ + L ELD
Sbjct: 598 ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELD 657
Query: 209 ISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYR 267
IS N I+ +P+ +G+L +L L+ N + LP L L L +L+ S N +T +P
Sbjct: 658 ISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIY 717
Query: 268 KLHHLQVIILDNNPLQVPPAQICLKGK 294
+ L+ I D+NPL PP +IC KGK
Sbjct: 718 NIFSLKEINFDDNPLLRPPVEIC-KGK 743
Score = 87.0 bits (214), Expect = 6e-17
Identities = 66/232 (28%), Positives = 110/232 (47%), Gaps = 25/232 (10%)
Query: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
LE G+ ILSL KLR P + L +L N+ T P + L +L+L
Sbjct: 253 LECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG 312
Query: 144 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL------------------------ 179
N I ++P+ I+ L+ L L + N L+ L +F L
Sbjct: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
Query: 180 PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHV 239
L++L++ N L +IPE+I L L +S N++ LP+ + KL++LR+L++ RNN+
Sbjct: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
Query: 240 LPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQIC 290
+ D + L + L+FS N +T++P+ + + I L N + P +C
Sbjct: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484
Score = 80.9 bits (198), Expect = 4e-15
Identities = 63/236 (26%), Positives = 115/236 (48%), Gaps = 26/236 (11%)
Query: 70 SLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSD 129
SLQ ++ + SL ++ + IL++S + P L + Q N PSD
Sbjct: 194 SLQ-ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSD 252
Query: 130 VWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP--------- 180
+ LE L+L N ++ IP+ + +L+ L LN+ N L+T PK L LP
Sbjct: 253 LECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG 312
Query: 181 ---------------LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLH 225
L+ L++ +NKL + EI +L + EL ++ N+++V+ ++
Sbjct: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
Query: 226 SLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNN 280
LR L + +N L +P+++ +++ L S NK+TE+P KL++L+ + ++ N
Sbjct: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Score = 77.0 bits (188), Expect = 6e-14
Identities = 60/204 (29%), Positives = 98/204 (48%), Gaps = 3/204 (1%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
LSLS KL + P + L + + ++RN +I + + +L N I +P
Sbjct: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
IKN Q + + +S N + P L L L L V+ N + IP +I K L+ L++S
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSE 519
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKVTEIPVCYRKLH 270
N++ + + L +L+ L++ +N + +P + + + L L CNK P L
Sbjct: 520 NKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLE 579
Query: 271 HLQVIILDNNPLQVPPAQIC-LKG 293
+LQV+ L N LQ + IC LKG
Sbjct: 580 NLQVLDLSENQLQKISSDICNLKG 603
Score = 67.0 bits (162), Expect = 6e-11
Identities = 58/212 (27%), Positives = 102/212 (48%), Gaps = 8/212 (3%)
Query: 89 SSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKT 148
S + SL+GR ++ L+ T ++S E + L A T+NL ++
Sbjct: 97 SQSLSSLTGRTA-EYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQE 155
Query: 149 IPEAIKNLQMLTYLNISRNLLSTLPKYLFD--LPLKVLVVSNNKLVSIPEEIGKLKDLME 206
P+ I ++ + YL + +N + T L L++L + N L S+P EI L +L
Sbjct: 156 FPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRI 215
Query: 207 LDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDE---LGDLPLVKLDFSCNKVTEIP 263
L++S N I +P+++ +L ++R+L N + P + LG+L ++ L NK+ IP
Sbjct: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL--GKNKLRHIP 273
Query: 264 VCYRKLHHLQVIILDNNPLQVPPAQICLKGKV 295
L L+V+ L+ N L P +C K+
Sbjct: 274 DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/183 (26%), Positives = 85/183 (46%), Gaps = 2/183 (1%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L SG + D P + + +LS N+ P + L L++ N I IP
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
I + L +L +S N L ++ L LK L + N++ IP I + L L + C
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLH 270
N+ + P+++ L +L+ L++ N L + ++ +L + KL+FS N+ P+ +L
Sbjct: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
Query: 271 HLQ 273
L+
Sbjct: 626 SLE 628
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
L+ I + GRKL PG ++T + D+S N EIP ++ L +L+ Y+
Sbjct: 624 LQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYN 683
Query: 144 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLK 202
N I +P ++ +L L LN+S N L+ LP ++++ LK + +N L+ P EI K K
Sbjct: 684 NQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGK 743
Query: 203 DL 204
L
Sbjct: 744 QL 745
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 89.7 bits (221), Expect = 9e-18
Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 5/214 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
IL L +L+ P + LT + DL N FTE+P + + L+ + N + IP
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
I +L+ LTYL++S+N + + + + L+ L++S+N L +PE IG LK++ L I
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKID 284
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKL 269
N++ LP +G L S+ EL+ N + LP +G L L N + ++P
Sbjct: 285 ENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSW 344
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNI 303
++ V+ L +N L+ P ++ G + K +N+
Sbjct: 345 KNITVLFLHSNKLETLPEEM---GDMQKLKVINL 375
Score = 82.0 bits (201), Expect = 2e-15
Identities = 75/312 (24%), Positives = 134/312 (42%), Gaps = 8/312 (2%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ ++ L + + L L + + P L+ + + NR T IP +
Sbjct: 170 ENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV 192
L L++ N I+ + E I + L L +S N L LP+ + L + L + N+L+
Sbjct: 230 KQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Query: 193 SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
+P+ IG L + ELD S NE++ LP +G+L +LR N L LP E+G + +
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITV 349
Query: 253 DF-SCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQA--CCRM 309
F NK+ +P + L+VI L +N L+ P ++ + Q+ +
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 310 DKKPDS--LDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDD 367
K+ DS + + P QP T+ + N++ P + + ++R D+D
Sbjct: 410 QKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNP--SLWEEQRKQRAQVAFECDED 467
Query: 368 TVSLHSQVSESN 379
+ E N
Sbjct: 468 KDEREAPPREGN 479
Score = 77.8 bits (190), Expect = 4e-14
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 2/215 (0%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+ L + L S LSL L P S +L + + D+S+N E P ++ L
Sbjct: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIP 195
+ N I +P+ L LT L ++ L LP L L++L + N+L +P
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 196 EEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDF 254
+ + +L L LD+ NE +P+ + +L L+E + N L +P +G L L LD
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDV 237
Query: 255 SCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
S N + + +LQ ++L +N LQ P I
Sbjct: 238 SKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 56.6 bits (135), Expect = 8e-08
Identities = 86/432 (19%), Positives = 170/432 (39%), Gaps = 48/432 (11%)
Query: 71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDV 130
L ++++ L + + L + +L P S L + D S N +PS +
Sbjct: 259 LLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI 318
Query: 131 WLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNN 189
L T HN ++ +P I + + +T L + N L TLP+ + D+ LKV+ +S+N
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Query: 190 KLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPL 249
+L ++P KL+ L + +S N+ + L + S + + N + D+
Sbjct: 379 RLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
Query: 250 VKLDFSCNKVTEIPVCYRKLHHLQVIIL-----DNNPLQVPPAQICLKGKVHIFKYLNIQ 304
+ + S N P + + + + D + + PP + LK +Y
Sbjct: 439 ISDNESFN-----PSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLK------RY---- 483
Query: 305 ACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPS 364
P +L ++ K + Q + ++D N++ G D D + +
Sbjct: 484 ------PTPYPDELKNMVKTV--QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKT 535
Query: 365 DDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQGNAHI 424
+ T ++ S+V E + ++IG+ QK E + P + V + + ++
Sbjct: 536 SESTTTVKSKVDE--------REKYMIGNSV--QKISEPEAEISPGSLPVTANMKASENL 585
Query: 425 GSFVS----FFKGKEKCSEKSRKNEELGD---EKRLEKEQL--LAEEEDDDLKEVTDLRK 475
V+ F + +E S++ K E+ E + + ++ L+ + DD KE L
Sbjct: 586 KHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSD 645
Query: 476 IAAQLLQQEQKN 487
Q N
Sbjct: 646 EVTHNSNQNNSN 657
Score = 56.2 bits (134), Expect = 1e-07
Identities = 34/146 (23%), Positives = 79/146 (54%), Gaps = 3/146 (2%)
Query: 157 QMLTYLNISRNLLSTLPK--YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEI 214
+ +T L+ S L +PK + F+ L+ L + N++ +P+++ + L +L + N++
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 215 QVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL-DFSCNKVTEIPVCYRKLHHLQ 273
LP + L +LREL++ +N + P+ + + ++ + + S N ++++P + +L +L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 274 VIILDNNPLQVPPAQICLKGKVHIFK 299
+ L++ L+ PA K+ I +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILE 167
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 89.7 bits (221), Expect = 9e-18
Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 5/214 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
IL L +L+ P + LT + DL N FTE+P + + L+ + N + IP
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
I +L+ LTYL++S+N + + + + L+ L++S+N L +PE IG LK++ L I
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKID 284
Query: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKL 269
N++ LP +G L S+ EL+ N + LP +G L L N + ++P
Sbjct: 285 ENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSW 344
Query: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNI 303
++ V+ L +N L+ P ++ G + K +N+
Sbjct: 345 KNITVLFLHSNKLETLPEEM---GDMQKLKVINL 375
Score = 82.0 bits (201), Expect = 2e-15
Identities = 75/312 (24%), Positives = 134/312 (42%), Gaps = 8/312 (2%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
++ ++ L + + L L + + P L+ + + NR T IP +
Sbjct: 170 ENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Query: 134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV 192
L L++ N I+ + E I + L L +S N L LP+ + L + L + N+L+
Sbjct: 230 KQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Query: 193 SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
+P+ IG L + ELD S NE++ LP +G+L +LR N L LP E+G + +
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITV 349
Query: 253 DF-SCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQA--CCRM 309
F NK+ +P + L+VI L +N L+ P ++ + Q+ +
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 310 DKKPDS--LDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDD 367
K+ DS + + P QP T+ + N++ P + + ++R D+D
Sbjct: 410 QKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNP--SLWEEQRKQRAQVAFECDED 467
Query: 368 TVSLHSQVSESN 379
+ E N
Sbjct: 468 KDEREAPPREGN 479
Score = 77.8 bits (190), Expect = 4e-14
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 2/215 (0%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+ L + L S LSL L P S +L + + D+S+N E P ++ L
Sbjct: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIP 195
+ N I +P+ L LT L ++ L LP L L++L + N+L +P
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 196 EEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDF 254
+ + +L L LD+ NE +P+ + +L L+E + N L +P +G L L LD
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDV 237
Query: 255 SCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
S N + + +LQ ++L +N LQ P I
Sbjct: 238 SKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 56.6 bits (135), Expect = 8e-08
Identities = 86/432 (19%), Positives = 170/432 (39%), Gaps = 48/432 (11%)
Query: 71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDV 130
L ++++ L + + L + +L P S L + D S N +PS +
Sbjct: 259 LLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI 318
Query: 131 WLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNN 189
L T HN ++ +P I + + +T L + N L TLP+ + D+ LKV+ +S+N
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Query: 190 KLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPL 249
+L ++P KL+ L + +S N+ + L + S + + N + D+
Sbjct: 379 RLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
Query: 250 VKLDFSCNKVTEIPVCYRKLHHLQVIIL-----DNNPLQVPPAQICLKGKVHIFKYLNIQ 304
+ + S N P + + + + D + + PP + LK +Y
Sbjct: 439 ISDNESFN-----PSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLK------RY---- 483
Query: 305 ACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPS 364
P +L ++ K + Q + ++D N++ G D D + +
Sbjct: 484 ------PTPYPDELKNMVKTV--QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKT 535
Query: 365 DDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQGNAHI 424
+ T ++ S+V E + ++IG+ QK E + P + V + + ++
Sbjct: 536 SESTTTVKSKVDE--------REKYMIGNSV--QKISEPEAEISPGSLPVTANMKASENL 585
Query: 425 GSFVS----FFKGKEKCSEKSRKNEELGD---EKRLEKEQL--LAEEEDDDLKEVTDLRK 475
V+ F + +E S++ K E+ E + + ++ L+ + DD KE L
Sbjct: 586 KHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSD 645
Query: 476 IAAQLLQQEQKN 487
Q N
Sbjct: 646 EVTHNSNQNNSN 657
Score = 56.2 bits (134), Expect = 1e-07
Identities = 34/146 (23%), Positives = 79/146 (54%), Gaps = 3/146 (2%)
Query: 157 QMLTYLNISRNLLSTLPK--YLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEI 214
+ +T L+ S L +PK + F+ L+ L + N++ +P+++ + L +L + N++
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 215 QVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL-DFSCNKVTEIPVCYRKLHHLQ 273
LP + L +LREL++ +N + P+ + + ++ + + S N ++++P + +L +L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 274 VIILDNNPLQVPPAQICLKGKVHIFK 299
+ L++ L+ PA K+ I +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILE 167
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 89.4 bits (220), Expect = 1e-17
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 45/202 (22%)
Query: 126 IPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP----- 180
+P ++ LE LN ++N I+ +P I +LQ L +LN+ N L+TLP+ LP
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 181 ---------------------LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQ 219
L+ L +S+N +P +IGKL L L + N++ LP+
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 220 QMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDN 279
++G+L L+EL+I+ N L VLP ELG+L L QV +N
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLT-------------------GQKQVFKAEN 162
Query: 280 NPLQVPPAQICLKGKVHIFKYL 301
NP P A G H+F+Y+
Sbjct: 163 NPWVTPIADQFQLGVSHVFEYI 184
Score = 44.3 bits (103), Expect = 4e-04
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 6/123 (4%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRD--FPGSGYDLTDTTQADLSRNRFTEIPSDVWLFA 134
+ +L R + +L L+ L + PG+ + LT LS N F +P D+
Sbjct: 45 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 104
Query: 135 PLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPL----KVLVVSNNK 190
L+ L+L N + ++P+ I L L L+I N L+ LP L +L L +V NN
Sbjct: 105 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNP 164
Query: 191 LVS 193
V+
Sbjct: 165 WVT 167
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 89.4 bits (220), Expect = 1e-17
Identities = 72/211 (34%), Positives = 109/211 (51%), Gaps = 6/211 (2%)
Query: 88 GSSGILSLSGRKLRDFP-GSGYDLTDTTQADLSRNRFTEIPSDVW-LFAPLETLNLYHNC 145
G L+L L + P G G L L RNRF +P V L L L++ HN
Sbjct: 63 GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122
Query: 146 IKTI-PEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKD 203
+ + E + L+ L LN+S N L LP L L L+ L VS N+L +P+ + L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSR 182
Query: 204 LMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEI 262
L LD+ N++ P+Q+ +L +L EL++ N L LP+++ L +K L S ++ +
Sbjct: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL 242
Query: 263 PVCYRKLHHLQVIILDNNPLQVPPAQI-CLK 292
P + +L L+ ++LDNN LQ PAQ CL+
Sbjct: 243 PAGFCELASLESLMLDNNGLQALPAQFSCLQ 273
Score = 84.7 bits (208), Expect = 3e-16
Identities = 69/232 (29%), Positives = 99/232 (42%), Gaps = 46/232 (19%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDV---------WL----------- 132
L + +L FP L + D+S NR +P D+ WL
Sbjct: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
Query: 133 ---FAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSN 188
A LE+L L +N ++ +P LQ L LN+S NL P L L L+ L +S
Sbjct: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSR 305
Query: 189 NKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP 248
N+L S+P I L L+ L + N I+ LP + +L L EL ++ N + VLPD G L
Sbjct: 306 NQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLS 365
Query: 249 LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY 300
V L + +NPL PP ++C+KG +I Y
Sbjct: 366 RVGL----------------------WKIKDNPLIQPPYEVCMKGIPYIAAY 395
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/169 (30%), Positives = 78/169 (46%), Gaps = 1/169 (0%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+R L + + IL LSG +L P +L L N +P+ L
Sbjct: 216 LRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRL 275
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIP 195
+ LNL N + P A+ L L L +SRN L+++P + L L L + NN++ +P
Sbjct: 276 KMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLP 335
Query: 196 EEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDEL 244
+ I +L L EL + N+I VLP G+L + I+ N L P E+
Sbjct: 336 DSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/242 (30%), Positives = 116/242 (47%), Gaps = 11/242 (4%)
Query: 100 LRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQML 159
LR G DT A L R T +P+ + A L L+L N ++T+P + ++ L
Sbjct: 92 LRSLVLKGGQRRDTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGL 150
Query: 160 TYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLP 218
L +S N LS LP+ L LP L L V++N+L ++P +G L L LD+S N + LP
Sbjct: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
Query: 219 QQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIIL 277
++G L SL ELN+ N L LP L L ++ L N + +P +L L + L
Sbjct: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
Query: 278 DNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLP--SLSKRMPSQPLTDSME 335
+N L+ P ++ ++ +Q + PD+ P +L MP LT ++
Sbjct: 271 RDNQLRDLPPELL------DAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLD 324
Query: 336 DF 337
F
Sbjct: 325 SF 326
Score = 80.5 bits (197), Expect = 5e-15
Identities = 57/172 (33%), Positives = 86/172 (50%), Gaps = 6/172 (3%)
Query: 87 AGSSGI-----LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNL 141
AG SG+ L LS L P + LS N +E+P + L L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
Query: 142 YHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGK 200
HN ++T+P A+ L L L++S+NLL TLP + L L L +++N+L S+P +
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
L+ L L + N + +P + +L L L++R N L LP EL D P V+L
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRL 290
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/148 (29%), Positives = 77/148 (52%), Gaps = 1/148 (0%)
Query: 75 HTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFA 134
+++ +L + + G L LS L + P + L T ++ NR +P + +
Sbjct: 135 NSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALS 194
Query: 135 PLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVS 193
L+ L+L N + T+P I L L LN++ N L +LP L L L++LV+ +N L S
Sbjct: 195 TLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLAS 254
Query: 194 IPEEIGKLKDLMELDISCNEIQVLPQQM 221
+P ++ +L L LD+ N+++ LP ++
Sbjct: 255 VPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 69 GSLQPQHTVRS-LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIP 127
G+L H S L AL + L+++ +L+ P + L+ + DLS+N +P
Sbjct: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
Query: 128 SDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKV-LVV 186
++ L LNL N ++++P ++ L+ L L + NLL+++P L LPL L +
Sbjct: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
Query: 187 SNNKLVSIPEEI 198
+N+L +P E+
Sbjct: 271 RDNQLRDLPPEL 282
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/104 (27%), Positives = 47/104 (45%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+++L AL + L LS L P L + +L+ NR +P+ + L
Sbjct: 183 LQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 242
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
L L+ N + ++P + L +LT L++ N L LP L D P
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/242 (30%), Positives = 116/242 (47%), Gaps = 11/242 (4%)
Query: 100 LRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQML 159
LR G DT A L R T +P+ + A L L+L N ++T+P + ++ L
Sbjct: 92 LRSLVLKGGQRRDTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGL 150
Query: 160 TYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLP 218
L +S N LS LP+ L LP L L V++N+L ++P +G L L LD+S N + LP
Sbjct: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
Query: 219 QQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIIL 277
++G L SL ELN+ N L LP L L ++ L N + +P +L L + L
Sbjct: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
Query: 278 DNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLP--SLSKRMPSQPLTDSME 335
+N L+ P ++ ++ +Q + PD+ P +L MP LT ++
Sbjct: 271 RDNQLRDLPPELL------DAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLD 324
Query: 336 DF 337
F
Sbjct: 325 SF 326
Score = 80.5 bits (197), Expect = 5e-15
Identities = 57/172 (33%), Positives = 86/172 (50%), Gaps = 6/172 (3%)
Query: 87 AGSSGI-----LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNL 141
AG SG+ L LS L P + LS N +E+P + L L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
Query: 142 YHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGK 200
HN ++T+P A+ L L L++S+NLL TLP + L L L +++N+L S+P +
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKL 252
L+ L L + N + +P + +L L L++R N L LP EL D P V+L
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRL 290
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/148 (29%), Positives = 77/148 (52%), Gaps = 1/148 (0%)
Query: 75 HTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFA 134
+++ +L + + G L LS L + P + L T ++ NR +P + +
Sbjct: 135 NSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALS 194
Query: 135 PLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVS 193
L+ L+L N + T+P I L L LN++ N L +LP L L L++LV+ +N L S
Sbjct: 195 TLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLAS 254
Query: 194 IPEEIGKLKDLMELDISCNEIQVLPQQM 221
+P ++ +L L LD+ N+++ LP ++
Sbjct: 255 VPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 69 GSLQPQHTVRS-LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIP 127
G+L H S L AL + L+++ +L+ P + L+ + DLS+N +P
Sbjct: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
Query: 128 SDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKV-LVV 186
++ L LNL N ++++P ++ L+ L L + NLL+++P L LPL L +
Sbjct: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
Query: 187 SNNKLVSIPEEI 198
+N+L +P E+
Sbjct: 271 RDNQLRDLPPEL 282
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/104 (27%), Positives = 47/104 (45%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+++L AL + L LS L P L + +L+ NR +P+ + L
Sbjct: 183 LQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 242
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
L L+ N + ++P + L +LT L++ N L LP L D P
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 89.0 bits (219), Expect = 2e-17
Identities = 69/233 (29%), Positives = 120/233 (51%), Gaps = 27/233 (11%)
Query: 76 TVRSLDRALEEAGSSGILSLSGRKLRDFPGSG-----------------------YDLTD 112
T R L +AL ++ I++L+G+K+ P + +LT
Sbjct: 2 TERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ 61
Query: 113 TTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCI-KTIPEAIKNLQMLTYLNISRNLLST 171
T +L N E+P ++ L+ L+L N I + P A LQ L LN++ N L+
Sbjct: 62 LTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQ 121
Query: 172 LPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLREL 230
LP+ + L L + ++ N+L SIP E+ L++L+EL ++ N++ +P+++ L L++L
Sbjct: 122 LPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
Query: 231 NIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPL 282
+ RNN+ VLP+EL DL ++ LD + N + P ++ L L+ + NPL
Sbjct: 182 LLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/140 (27%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
Query: 154 KNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCN 212
KN +++T ++ ++ +P L LP LK LV+ NN + + E+ L L L++ N
Sbjct: 14 KNTKIIT---LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
Query: 213 EIQVLPQQMGKLHSLRELNIRRNNL-HVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLH 270
++ +P++M L SL+ L++ N + P L L+ L+ + N +T++P +L
Sbjct: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
Query: 271 HLQVIILDNNPLQVPPAQIC 290
L + ++ N L P ++C
Sbjct: 131 SLTYMSINYNQLASIPRELC 150
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 88.2 bits (217), Expect = 3e-17
Identities = 59/173 (34%), Positives = 95/173 (54%), Gaps = 7/173 (4%)
Query: 117 DLSRNRFTE--IPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPK 174
DLS N F P +V L L L + +PE + LQ L +L++S N L+TL
Sbjct: 14 DLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHG 73
Query: 175 YLFDLP-LKVLVVSNNKLVS--IPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELN 231
L LP L+ +V N L + +P++I KL DL LD+S N++ P+++ ++ LN
Sbjct: 74 ELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLN 133
Query: 232 IRRNNLHVLPDEL--GDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPL 282
+ N++ +P++L L+ LD S N++ +P R+L HLQ ++L+ NPL
Sbjct: 134 LSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL 186
Score = 82.0 bits (201), Expect = 2e-15
Identities = 65/205 (31%), Positives = 106/205 (51%), Gaps = 7/205 (3%)
Query: 104 PGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIK-NLQMLTYL 162
P + L D + DLS N+ TE P ++ + LNL HN I TIP + NL L YL
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
Query: 163 NISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIP-EEIGKLKDLMELDISCNEIQV--LP 218
++S N L +LP + L L+ LV++ N L+ ++ + L L + + LP
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLP 216
Query: 219 QQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIIL 277
+ L +L ++++ N+L +P+ L LP L +L+ S N++TE+ +C + H++ + L
Sbjct: 217 TSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL 276
Query: 278 DNNPLQVPPAQICLKGKVHIFKYLN 302
N L P+ IC K+ YLN
Sbjct: 277 SRNQLTSLPSAICKLSKLKKL-YLN 300
Score = 75.1 bits (183), Expect = 2e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 8/178 (4%)
Query: 126 IPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFD--LPLKV 183
+P D++ L L+L HN + P ++N + + LN+S N + T+P LF L
Sbjct: 96 VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLY 155
Query: 184 LVVSNNKLVSIPEEIGKLKDLMELDISCNE-IQVLPQQMGKLHSLRELNIR--RNNLHVL 240
L +S N+L S+P ++ +L L L ++ N + +Q+ + +L+ L++R + L
Sbjct: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNL 215
Query: 241 PDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
P L L L +D SCN +T +P C L L+ + L +N Q+ +C+ VH+
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSN--QITELSLCIDQWVHV 271
Score = 74.3 bits (181), Expect = 4e-13
Identities = 69/260 (26%), Positives = 113/260 (43%), Gaps = 55/260 (21%)
Query: 82 RALEEAGSSGILSLSGRKLRDFPGSGY-DLTDTTQADLSRNRFTEIPSDVWLFAPLETLN 140
R LE A + +L+LS + P + +LTD DLS NR +P + L+TL
Sbjct: 121 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 180
Query: 141 LYHNCI--------------------------KTIPEAIKNLQMLTYLNISRNLLSTLPK 174
L N + +P +++ L L +++S N L+ +P+
Sbjct: 181 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
Query: 175 YLFDLP------------------------LKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
L+ LP ++ L +S N+L S+P I KL L +L ++
Sbjct: 241 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300
Query: 211 CNEIQV--LPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYR 267
N++ LP +GKL +L E NNL ++P+ L P L KL + N + +P
Sbjct: 301 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 360
Query: 268 KLHHLQVIILDNNP-LQVPP 286
L ++V+ + NP L +PP
Sbjct: 361 FLTEIEVLDVRENPNLVMPP 380
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/176 (28%), Positives = 85/176 (48%), Gaps = 3/176 (1%)
Query: 74 QHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
Q T +L +LE + + LS L P Y L + +LS N+ TE+ + +
Sbjct: 209 QRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQW 268
Query: 134 APLETLNLYHNCIKTIPEAIKNLQML--TYLNISRNLLSTLPKYLFDLP-LKVLVVSNNK 190
+ETLNL N + ++P AI L L YLN ++ LP + L L+ + +NN
Sbjct: 269 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNN 328
Query: 191 LVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD 246
L +PE + + L +L ++ N + LP+ + L + L++R N V+P + D
Sbjct: 329 LELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 3/112 (2%)
Query: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNL--H 238
L+ L ++ L +PEE+ L+ L L +S N + L ++ L SLR + R N+L
Sbjct: 35 LRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNS 94
Query: 239 VLPDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
+PD++ L L LD S N++TE P ++ V+ L +N + P Q+
Sbjct: 95 GVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 87.8 bits (216), Expect = 3e-17
Identities = 60/175 (34%), Positives = 94/175 (53%), Gaps = 4/175 (2%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWL--FAPLETLNLYHNCIKTIP 150
L L +L P + + L++ + DL N I + L L L+HN I TIP
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
Query: 151 EAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDI 209
+I +++ L L S N L +LP +F L L+ L VS N + IP EIG L++L L I
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
Query: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIP 263
+ N++ +LP+Q+ K LR LN+ +N + LP+++G L L +L+ N + +P
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/184 (31%), Positives = 98/184 (53%), Gaps = 4/184 (2%)
Query: 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAI--KNLQMLTYLNISRN 167
+ + + +L IP ++ + L+ L+L N I+TI E I ++L+ LT L + N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 168 LLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHS 226
+ T+P + + L+ L SNNKL S+P + L+ L LD+S N I ++P ++G L +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 227 LRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVP 285
L+ L+I N + +LP +L + L L+ N +T +P +L L + L N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 286 PAQI 289
PAQ+
Sbjct: 814 PAQL 817
Score = 70.1 bits (170), Expect = 7e-12
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 7/172 (4%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L L K+ P S + + S N+ +P V+ L L++ +N I IP
Sbjct: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
I LQ L +L+I+ N + LPK LF + L+ L + N + S+PE++G+L L +L++
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIP 263
N + LP Q+G+ L++ + V+ D L D +++ + N+ IP
Sbjct: 808 NCLDRLPAQLGQCRMLKKSGL------VVEDHLFDTLPLEVKEALNQDINIP 853
Score = 54.3 bits (129), Expect = 4e-07
Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 8/181 (4%)
Query: 120 RNRFTEIPSDVWLFAPLETLNLYHN--CIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLF 177
++ T++PS++ AP T + HN + ++K + + L + L +P +F
Sbjct: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
Query: 178 DLP-LKVLVVSNNKLVSIPEEIG--KLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
L L+ L + +N + +I E I LK L L + N+I +P + + +L L
Sbjct: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN 715
Query: 235 NNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI--CL 291
N L LP + L ++ LD S N ++ IP+ L +LQ + + N + + P Q+ C+
Sbjct: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
Query: 292 K 292
K
Sbjct: 776 K 776
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/178 (24%), Positives = 90/178 (50%), Gaps = 16/178 (8%)
Query: 125 EIPSDVWLFAPLETLNLYHNCI----KTIP-EAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
EIP+ V+L L L L N K I E+++ L+ L L++ NL + +P + D+
Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDV 609
Query: 180 P---LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
K+++ ++ + + + K+ ++ EL++ E++ +P + L +L+EL+++ NN
Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
Query: 237 LHVLPDELGDLPLVKLDFSC-----NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
+ + + + L +L +C NK+ IP + +L+ + NN L+ P +
Sbjct: 670 IRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 87.8 bits (216), Expect = 3e-17
Identities = 60/175 (34%), Positives = 94/175 (53%), Gaps = 4/175 (2%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWL--FAPLETLNLYHNCIKTIP 150
L L +L P + + L++ + DL N I + L L L+HN I TIP
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
Query: 151 EAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDI 209
+I +++ L L S N L +LP +F L L+ L VS N + IP EIG L++L L I
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
Query: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIP 263
+ N++ +LP+Q+ K LR LN+ +N + LP+++G L L +L+ N + +P
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/184 (31%), Positives = 98/184 (53%), Gaps = 4/184 (2%)
Query: 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAI--KNLQMLTYLNISRN 167
+ + + +L IP ++ + L+ L+L N I+TI E I ++L+ LT L + N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 168 LLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHS 226
+ T+P + + L+ L SNNKL S+P + L+ L LD+S N I ++P ++G L +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 227 LRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVP 285
L+ L+I N + +LP +L + L L+ N +T +P +L L + L N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 286 PAQI 289
PAQ+
Sbjct: 814 PAQL 817
Score = 70.1 bits (170), Expect = 7e-12
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 7/172 (4%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L L K+ P S + + S N+ +P V+ L L++ +N I IP
Sbjct: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
I LQ L +L+I+ N + LPK LF + L+ L + N + S+PE++G+L L +L++
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
Query: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIP 263
N + LP Q+G+ L++ + V+ D L D +++ + N+ IP
Sbjct: 808 NCLDRLPAQLGQCRMLKKSGL------VVEDHLFDTLPLEVKEALNQDINIP 853
Score = 54.3 bits (129), Expect = 4e-07
Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 8/181 (4%)
Query: 120 RNRFTEIPSDVWLFAPLETLNLYHN--CIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLF 177
++ T++PS++ AP T + HN + ++K + + L + L +P +F
Sbjct: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
Query: 178 DLP-LKVLVVSNNKLVSIPEEIG--KLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
L L+ L + +N + +I E I LK L L + N+I +P + + +L L
Sbjct: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN 715
Query: 235 NNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI--CL 291
N L LP + L ++ LD S N ++ IP+ L +LQ + + N + + P Q+ C+
Sbjct: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
Query: 292 K 292
K
Sbjct: 776 K 776
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/178 (24%), Positives = 90/178 (50%), Gaps = 16/178 (8%)
Query: 125 EIPSDVWLFAPLETLNLYHNCI----KTIP-EAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
EIP+ V+L L L L N K I E+++ L+ L L++ NL + +P + D+
Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDV 609
Query: 180 P---LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
K+++ ++ + + + K+ ++ EL++ E++ +P + L +L+EL+++ NN
Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
Query: 237 LHVLPDELGDLPLVKLDFSC-----NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
+ + + + L +L +C NK+ IP + +L+ + NN L+ P +
Sbjct: 670 IRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 87.8 bits (216), Expect = 3e-17
Identities = 58/149 (38%), Positives = 85/149 (57%), Gaps = 5/149 (3%)
Query: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSI 194
L L L HNC+ +PEA+ L LT+L ++ N L TLP L L L+ L +S N L ++
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 195 PEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLV-KLD 253
P EIG L L+EL+++ N +Q LP + L SLR L + N L +P +L LPL+ +LD
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 254 FSCNKVTEIPVCYRKLHHLQVIILDNNPL 282
N++ ++P +L + L NPL
Sbjct: 124 LRDNQLRDLP---PELLDAPFVRLQGNPL 149
Score = 73.9 bits (180), Expect = 5e-13
Identities = 47/157 (29%), Positives = 86/157 (54%), Gaps = 6/157 (3%)
Query: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
L L++S+N L +PE +G L L L ++ N +Q LP +G L +L+ L++ +N L L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 241 PDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFK 299
P E+G L L++L+ + N++ +P L L++++L +N L PA + ++ +
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLT 120
Query: 300 YLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMED 336
L+++ D P+ LD P + R+ PL ++ D
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFV--RLQGNPLGEASPD 155
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/180 (31%), Positives = 88/180 (48%), Gaps = 10/180 (5%)
Query: 162 LNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQ 220
L +S N LS LP+ L LP L L V++N+L ++P +G L L LD+S N + LP +
Sbjct: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
Query: 221 MGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDN 279
+G L SL ELN+ N L LP L L ++ L N + +P +L L + L +
Sbjct: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
Query: 280 NPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLP--SLSKRMPSQPLTDSMEDF 337
N L+ P ++ ++ +Q + PD+ P +L MP LT ++ F
Sbjct: 127 NQLRDLPPELL------DAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 69 GSLQPQHTVRS-LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIP 127
G+L H S L AL + L+++ +L+ P + L+ + DLS+N +P
Sbjct: 5 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 64
Query: 128 SDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKV-LVV 186
++ L LNL N ++++P ++ L+ L L + NLL+++P L LPL L +
Sbjct: 65 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 124
Query: 187 SNNKLVSIPEEI 198
+N+L +P E+
Sbjct: 125 RDNQLRDLPPEL 136
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/104 (27%), Positives = 47/104 (45%)
Query: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
+++L AL + L LS L P L + +L+ NR +P+ + L
Sbjct: 37 LQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 96
Query: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
L L+ N + ++P + L +LT L++ N L LP L D P
Sbjct: 97 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 140
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 87.0 bits (214), Expect = 6e-17
Identities = 58/179 (32%), Positives = 100/179 (55%), Gaps = 7/179 (3%)
Query: 117 DLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNL-LSTLPKY 175
DLSRN +EIP + L L+ L L +N IKT+P+ + N L L ++ N + LP+
Sbjct: 112 DLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQE 171
Query: 176 LFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
L + L L L +S N +IP + + L LD+ N+++ LP + ++ +L L ++R
Sbjct: 172 LSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQR 231
Query: 235 NNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQ----VPPAQ 288
N + LP + ++ L L S NK+ +IPVC ++ +L+ + +NPL+ +PP++
Sbjct: 232 NEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSE 290
Score = 78.2 bits (191), Expect = 3e-14
Identities = 59/216 (27%), Positives = 102/216 (47%), Gaps = 6/216 (2%)
Query: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
IL + + + P S L + L R +IP + F L L+L N I IP
Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
Query: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLPL--KVLVVSNNKLVSIPEEIGKLKDLMELDI 209
I L L L +S N + T+PK L + K+ + N + +P+E+ L L LD+
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
Query: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRK 268
S N+ +P + + +L L++ N L LPD + + L L N++T +P
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
Query: 269 LHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQ 304
+ +L ++L NN LQ P +C++ ++ +++N +
Sbjct: 244 MKNLGTLVLSNNKLQDIP--VCMEEMANL-RFVNFR 276
Score = 60.8 bits (146), Expect = 4e-09
Identities = 44/131 (33%), Positives = 70/131 (53%), Gaps = 5/131 (3%)
Query: 77 VRSLDRALEEAGSSGILSLS-GRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAP 135
++++ + L S L L+ R + D P +L T DLS N FT IP V
Sbjct: 141 IKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPA 200
Query: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSI 194
LE L++ N ++ +P+ I+ +Q L L + RN ++ LP+ + ++ L LV+SNNKL I
Sbjct: 201 LEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDI 260
Query: 195 P---EEIGKLK 202
P EE+ L+
Sbjct: 261 PVCMEEMANLR 271
Score = 48.1 bits (113), Expect = 3e-05
Identities = 50/166 (30%), Positives = 70/166 (42%), Gaps = 31/166 (18%)
Query: 189 NKLVSIPEEIGKLKDLME----------LDISCNEIQVLPQQMGKLHSLRELNIRRNNLH 238
+KLV I EE L L E L I E + LP + KL+ L+E + R L
Sbjct: 37 HKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL 96
Query: 239 VLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
+P+ +G L+ LD S N ++EIP L LQ +IL N ++ P +
Sbjct: 97 KIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKE--------- 147
Query: 298 FKYLNIQACCRMDK-----KPDSLDLP-SLSKRMPSQPLTDSMEDF 337
+ C ++K D DLP LS + L SM DF
Sbjct: 148 -----LSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDF 188
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 85.5 bits (210), Expect = 2e-16
Identities = 58/166 (34%), Positives = 92/166 (55%), Gaps = 3/166 (1%)
Query: 118 LSRNRFTEIPSDVWLFAP-LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL 176
+ RN T +P ++ P L L L+ N I +PEAI +L L L++S N L + +
Sbjct: 48 MKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEI 107
Query: 177 FDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRN 235
L L+ L ++NN+L +P E+G LK+L LDIS N + LP+++ SL+ L + RN
Sbjct: 108 GRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRN 167
Query: 236 NLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNN 280
L +P L LP L +L + N++ +P+ + LQ + +DNN
Sbjct: 168 RLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
Score = 84.0 bits (206), Expect = 5e-16
Identities = 55/154 (35%), Positives = 86/154 (55%), Gaps = 5/154 (3%)
Query: 140 NLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFD-LP-LKVLVVSNNKLVSIPEE 197
NL+H ++ + + + LQ L L + RN L++LP+ L LP L L + +N +V +PE
Sbjct: 26 NLHHFPLELLKD--EGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEA 83
Query: 198 IGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSC 256
IG L L LD+S N ++++ ++G+L +LR L + N L LP E+GDL L LD S
Sbjct: 84 IGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
Query: 257 NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQIC 290
N++ +P LQ + +D N L P +C
Sbjct: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/121 (25%), Positives = 54/121 (44%), Gaps = 24/121 (19%)
Query: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
L L+ +L+ P DL + D+S NR + T+PE
Sbjct: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNR-----------------------LLTLPER 152
Query: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
+ L YL + RN L +P++L LP L L ++ N+L +P ++G+ ++L + +
Sbjct: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDN 212
Query: 212 N 212
N
Sbjct: 213 N 213
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 84.3 bits (207), Expect = 4e-16
Identities = 60/218 (27%), Positives = 112/218 (51%), Gaps = 32/218 (14%)
Query: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
+E A +G+ L R L +FP ADL + L + L T++L +
Sbjct: 10 VETAQKTGVFQLKDRGLTEFP-----------ADLQK-----------LTSNLRTIDLSN 47
Query: 144 NCIKTIPEA-IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKL 201
N I+++P I +L L+++ N L+ LP + +L L+ L ++NN L +P G+L
Sbjct: 48 NKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQL 107
Query: 202 KDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTE 261
L L +S N++ LP Q+ L L +++ +N + +PD +G+L +++L+ + N++++
Sbjct: 108 SALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQ 167
Query: 262 IPVCYRKLHHLQVIILDNNPLQ--------VPPAQICL 291
I V L+++ L+ N L+ + +QICL
Sbjct: 168 ISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICL 205
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/139 (30%), Positives = 58/139 (41%), Gaps = 7/139 (5%)
Query: 70 SLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSD 129
SL H +R L + + LSLSG +L P L DLS+N+ IP
Sbjct: 91 SLNNNH-LRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDS 149
Query: 130 VWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNN 189
V +E LNL N I I I L L + N L L LP +L S
Sbjct: 150 VGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLE-----LSMLPQSILSDSQI 203
Query: 190 KLVSIPEEIGKLKDLMELD 208
L+++ + ++K L EL+
Sbjct: 204 CLLAVEGNLFEIKKLRELE 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,755,970
Number of Sequences: 37866
Number of extensions: 1834408
Number of successful extensions: 41061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 624
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 15298
Number of HSP's gapped (non-prelim): 12056
length of query: 765
length of database: 18,247,518
effective HSP length: 110
effective length of query: 655
effective length of database: 14,082,258
effective search space: 9223878990
effective search space used: 9223878990
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.