Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 153791839
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791839 sodium channel associated protein 1 [Homo sapiens]
(688 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791839 sodium channel associated protein 1 [Homo sapiens] 1313 0.0
gi|38044112 restin isoform b [Homo sapiens] 119 1e-26
gi|4506751 restin isoform a [Homo sapiens] 119 1e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 116 8e-26
gi|156104908 myosin heavy chain 6 [Homo sapiens] 116 8e-26
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 115 1e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 115 1e-25
gi|58530840 desmoplakin isoform I [Homo sapiens] 112 1e-24
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 111 3e-24
gi|31982906 cingulin-like 1 [Homo sapiens] 110 3e-24
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 109 7e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 107 3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 107 4e-23
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 107 5e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 106 6e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 106 8e-23
gi|28269672 serologically defined colon cancer antigen 8 [Homo s... 106 8e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 105 1e-22
gi|71061468 centromere protein E [Homo sapiens] 105 2e-22
gi|55770834 centromere protein F [Homo sapiens] 104 3e-22
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 103 4e-22
gi|28416946 myosin 18A isoform a [Homo sapiens] 103 5e-22
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 103 7e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 103 7e-22
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 102 9e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 102 1e-21
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 101 2e-21
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 101 2e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 101 2e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 101 2e-21
>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
Length = 688
Score = 1313 bits (3398), Expect = 0.0
Identities = 688/688 (100%), Positives = 688/688 (100%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLV 60
MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLV
Sbjct: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLV 60
Query: 61 TEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVG 120
TEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVG
Sbjct: 61 TEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVG 120
Query: 121 TDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQ 180
TDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQ
Sbjct: 121 TDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQ 180
Query: 181 KQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVA 240
KQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVA
Sbjct: 181 KQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVA 240
Query: 241 KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ
Sbjct: 241 KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
Query: 301 LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED 360
LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED
Sbjct: 301 LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED 360
Query: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK 420
IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK
Sbjct: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK 420
Query: 421 EKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETD 480
EKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETD
Sbjct: 421 EKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETD 480
Query: 481 SSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK 540
SSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK
Sbjct: 481 SSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK 540
Query: 541 AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTE 600
AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTE
Sbjct: 541 AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTE 600
Query: 601 SAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEE 660
SAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEE
Sbjct: 601 SAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEE 660
Query: 661 RAASASQQLSVITVQRRKAASLMNLENI 688
RAASASQQLSVITVQRRKAASLMNLENI
Sbjct: 661 RAASASQQLSVITVQRRKAASLMNLENI 688
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 119 bits (297), Expect = 1e-26
Identities = 151/697 (21%), Positives = 310/697 (44%), Gaps = 81/697 (11%)
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL-GTE 118
+T +H G + + +QK++ + E + KENE L S+L+ A ++ + L ++
Sbjct: 524 ITSLKEHFG---AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 580
Query: 119 VGTDIYADDETVRNLQEQLQLA-NQEKTQAVEL-WQTVSQELDRLHK---LYQEHMTEAQ 173
+ T I + + + L+ E + EL Q LD H+ L + +E
Sbjct: 581 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 640
Query: 174 IHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKL 233
H E + + +L K + ++E + K + V +E KL++A++
Sbjct: 641 AHAKEMEALR------AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEI 694
Query: 234 ---ELRVAVAKVEELTNVTEDLQGQMKKKEKDVV--------SAHGREEASDRR--LQQL 280
EL V AK E T V ++ Q+K E+ ++ S+ G+ E R L+
Sbjct: 695 KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 754
Query: 281 QSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN-----ERYEAIVRARN 335
+ IK LEI +A+ + E E + LQ +E+ E+ I++ +
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814
Query: 336 SMQLLEEANLQKSQALLEEK--QKEE-------DIEKMKETVSRFV---------QDATI 377
+ E ++Q+S K QKEE D+EK++E ++ ++ I
Sbjct: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
Query: 378 RTKKEVANTKKQC-------NIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELE 430
+ K+++ N + + Q++++ +EL + + E Q ++ + + +++ +E
Sbjct: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 934
Query: 431 KIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQL----ETDSSEEIS 486
+ + ++ + K E ++ L ER DL+ ++ + N+ ++L E +SE +
Sbjct: 935 DMTVKAEQSQQEAAKKHEEEKKEL--ERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
Query: 487 RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLR--KIALEA----QKK 540
+++E++Q LQ L + E+ L QE ++LRK+ + + + A +A ++
Sbjct: 993 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1052
Query: 541 AKVKISTMEHEFSIKERGFEVQ--LREMEDSNRNSIVEL---RHLLATQQKAANRWKEET 595
K K T+ K+ ++Q L ++++N ++ EL + LL + + +++E
Sbjct: 1053 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1112
Query: 596 KKLTESAEIRINNLKSELSRQKLHTQELL--SQLEMANEKVAENEKLILEHQ--EKANRL 651
+ L ++A + L S L + + E L S+ E+ + + E E+ +L +Q E R
Sbjct: 1113 ETLKQAAAQKSQQL-SALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1171
Query: 652 QRRLSQAEERAASASQQLSVIT-VQRRKAASLMNLEN 687
+ + A+E AS + +S+ + + K A L L N
Sbjct: 1172 SKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208
Score = 67.0 bits (162), Expect = 5e-11
Identities = 115/556 (20%), Positives = 232/556 (41%), Gaps = 82/556 (14%)
Query: 166 QEHMTEAQIHVFESQKQKD-QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQL 224
QE + E Q H+ + ++D + + + T + + + + + V E ++QL
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 225 RKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSI 284
R + A E + ++EE EDLQ ++ E++ ++ E A+ +S I
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRV---EEESITKGDLEVATVSE----KSRI 466
Query: 285 KQLEIRLCVTIQEANQLRTE------------NTHLEKQTRELQAKCNELENERYEAIVR 332
+LE L + +QE +LR + L ++ LQ K + I
Sbjct: 467 MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITS 526
Query: 333 ARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNI 392
+ EE + ++ +AL +K + K E++ ++ A +A K +
Sbjct: 527 LKEHFGAREETHQKEIKALYTATEK---LSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 393 QISRLTEELSALQM-----------ECAEKQGQIERV----------------------I 419
I+ + + L++ E AE + QIE++
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 420 KEKKAVEEELEKIYREGRGN-ESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLE 478
KE +A+ +L K+ +E + E+ KL++ + LV +D +L AE ++K+LE
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EMEDTLNKLQEAEIKVKELE 700
Query: 479 TDSSEEISRYQEMIQKLQNVLESERE---NCGLVSEQRLKLQQENKQLRKETESLRKIA- 534
+ + ++I + L++ E + + + + + E K+LR++ E+ K
Sbjct: 701 V-LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 759
Query: 535 -LEAQKKAK-VKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWK 592
LE +K A+ K S++ E +G E++L +++ ++ E+ + T +K K
Sbjct: 760 HLEIEKNAESSKASSITREL----QGRELKLTNLQE----NLSEVSQVKETLEKELQILK 811
Query: 593 EETKKLTESAEIRINNLKSELSRQKLHTQE-----LLSQLEMANEKVAENEKLILEHQEK 647
E+ + +E A +++ ++ KLH +E L S LE E +A+ E E E+
Sbjct: 812 EKFAEASEEAVSVQRSMQETVN--KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
Query: 648 ANRLQRRLSQAEERAA 663
+L + + E A
Sbjct: 870 EEQLIKAKEKLENDIA 885
Score = 59.7 bits (143), Expect = 9e-09
Identities = 103/507 (20%), Positives = 203/507 (40%), Gaps = 109/507 (21%)
Query: 249 TEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHL 308
T LQ +K+K++ + + + + S + ++E L + +Q
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-------- 401
Query: 309 EKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETV 368
EL+AK ++L R ++ + ++ L EEK+K ED++ E
Sbjct: 402 --HVLELEAKMDQL-----------RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE 448
Query: 369 SRFVQD---ATIRTKKEVANTKKQCNIQISRLTE----------------------ELSA 403
S D AT+ K + +K +++ + E E+S+
Sbjct: 449 SITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 508
Query: 404 LQMECAEKQGQIERVI---------------KEKKAVEEELEKIYREGRGNESDYRKLEE 448
LQ + + +R I KE KA+ EK+ +E NES KLE
Sbjct: 509 LQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKE---NESLKSKLEH 565
Query: 449 MH-QRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISR------------------YQ 489
+ + V K L+ + + +++L+ S+ + YQ
Sbjct: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
Query: 490 EMIQKLQNVLESER-ENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKI--- 545
I+ LQN +SER + + R KL + K+ E++R +A+ + V++
Sbjct: 626 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 685
Query: 546 --STMEHEFSIKERGFEVQLREMEDSNRNSIVE--LRHLLATQQ---------KAANRWK 592
E E +K E+++ + + + + +++ L AT++ KA++ K
Sbjct: 686 LNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741
Query: 593 EETKKL---TESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKAN 649
E KKL E+AE +I +L+ E + + + +L+ K+ ++ + E +
Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 650 RLQRRLSQAEERAASASQQLSVITVQR 676
L++ L +E+ A AS++ ++VQR
Sbjct: 802 TLEKELQILKEKFAEASEE--AVSVQR 826
Score = 50.4 bits (119), Expect = 5e-06
Identities = 67/342 (19%), Positives = 141/342 (41%), Gaps = 44/342 (12%)
Query: 364 MKETVSRFVQDATIRTKKEVANTKKQCNIQ------------ISRLTEELSALQMECAEK 411
+ ET SR+ + + T + A +KQ +I+ +++ T + ++ E A
Sbjct: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
Query: 412 QGQIERVIKEKKAVEEELEKIYREGRGN--------ESDYRKLEEMHQRFLVSERSKDDL 463
+ ++ + E +A ++L + E + RK+E++ R +K DL
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 464 QLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGL-----VSEQRLKLQQ 518
++ ++RI +LE D + + E+ ++L++ + + L +S + KL+
Sbjct: 456 EVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 515
Query: 519 ENKQLRKETESLRK---IALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIV 575
++E SL++ E +K + T + S + + +L N + I
Sbjct: 516 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 575
Query: 576 ----ELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLE--- 628
+L +A+ Q+A K K + LK+++ + +L Q + L+
Sbjct: 576 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 635
Query: 629 ------MANEKVAENEKLILEHQEKANRLQ---RRLSQAEER 661
A E A KL+ +EK N L+ +L +AE++
Sbjct: 636 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 677
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 119 bits (297), Expect = 1e-26
Identities = 151/697 (21%), Positives = 310/697 (44%), Gaps = 81/697 (11%)
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL-GTE 118
+T +H G + + +QK++ + E + KENE L S+L+ A ++ + L ++
Sbjct: 559 ITSLKEHFG---AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 615
Query: 119 VGTDIYADDETVRNLQEQLQLA-NQEKTQAVEL-WQTVSQELDRLHK---LYQEHMTEAQ 173
+ T I + + + L+ E + EL Q LD H+ L + +E
Sbjct: 616 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 675
Query: 174 IHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKL 233
H E + + +L K + ++E + K + V +E KL++A++
Sbjct: 676 AHAKEMEALR------AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEI 729
Query: 234 ---ELRVAVAKVEELTNVTEDLQGQMKKKEKDVV--------SAHGREEASDRR--LQQL 280
EL V AK E T V ++ Q+K E+ ++ S+ G+ E R L+
Sbjct: 730 KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 789
Query: 281 QSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN-----ERYEAIVRARN 335
+ IK LEI +A+ + E E + LQ +E+ E+ I++ +
Sbjct: 790 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 849
Query: 336 SMQLLEEANLQKSQALLEEK--QKEE-------DIEKMKETVSRFV---------QDATI 377
+ E ++Q+S K QKEE D+EK++E ++ ++ I
Sbjct: 850 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 909
Query: 378 RTKKEVANTKKQC-------NIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELE 430
+ K+++ N + + Q++++ +EL + + E Q ++ + + +++ +E
Sbjct: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 969
Query: 431 KIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQL----ETDSSEEIS 486
+ + ++ + K E ++ L ER DL+ ++ + N+ ++L E +SE +
Sbjct: 970 DMTVKAEQSQQEAAKKHEEEKKEL--ERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027
Query: 487 RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLR--KIALEA----QKK 540
+++E++Q LQ L + E+ L QE ++LRK+ + + + A +A ++
Sbjct: 1028 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1087
Query: 541 AKVKISTMEHEFSIKERGFEVQ--LREMEDSNRNSIVEL---RHLLATQQKAANRWKEET 595
K K T+ K+ ++Q L ++++N ++ EL + LL + + +++E
Sbjct: 1088 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Query: 596 KKLTESAEIRINNLKSELSRQKLHTQELL--SQLEMANEKVAENEKLILEHQ--EKANRL 651
+ L ++A + L S L + + E L S+ E+ + + E E+ +L +Q E R
Sbjct: 1148 ETLKQAAAQKSQQL-SALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1206
Query: 652 QRRLSQAEERAASASQQLSVIT-VQRRKAASLMNLEN 687
+ + A+E AS + +S+ + + K A L L N
Sbjct: 1207 SKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1243
Score = 73.6 bits (179), Expect = 6e-13
Identities = 117/540 (21%), Positives = 239/540 (44%), Gaps = 61/540 (11%)
Query: 166 QEHMTEAQIHVFESQKQKD-QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQL 224
QE + E Q H+ + ++D + + + T + + + + + V E ++QL
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 225 RKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSI 284
R + A E + ++EE EDLQ +++++ S + + +L+ + I
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE-----SITKGDLETQTKLE--HARI 466
Query: 285 KQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEAN 344
K+LE L +A++L+ E T +++ ELE + ++++ E A
Sbjct: 467 KELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL---------ALRVQEVAE 517
Query: 345 LQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSAL 404
L++ LE + D++ ++S + ++++ K EV T Q +I+ L E A
Sbjct: 518 LRRR---LESNKPAGDVDM---SLSLLQEISSLQEKLEVTRTDHQ--REITSLKEHFGAR 569
Query: 405 ----QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYR-KLE---EMHQRFLVS 456
Q E E++ KE ++++ +LE +E + ++ KLE HQ+ +
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM-- 627
Query: 457 ERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESER-ENCGLVSEQRLK 515
E K L +L+T + YQ I+ LQN +SER + + R K
Sbjct: 628 EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK 687
Query: 516 LQQENKQLRKETESLRKIALEAQKKAKVKI-----STMEHEFSIKERGFEVQLREMEDSN 570
L + K+ E++R +A+ + V++ E E +K E+++ + + +
Sbjct: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVLQAKCNE 743
Query: 571 RNSIVE--LRHLLATQQ---------KAANRWKEETKKL---TESAEIRINNLKSELSRQ 616
+ +++ L AT++ KA++ K E KKL E+AE +I +L+ E + +
Sbjct: 744 QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAE 803
Query: 617 KLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQR 676
+ +L+ K+ ++ + E + L++ L +E+ A AS++ ++VQR
Sbjct: 804 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE--AVSVQR 861
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/441 (19%), Positives = 189/441 (42%), Gaps = 59/441 (13%)
Query: 249 TEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHL 308
T LQ +K+K++ + + + + S + ++E L + +Q
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-------- 401
Query: 309 EKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETV 368
EL+AK ++L R ++ + ++ L EEK+K ED++ E
Sbjct: 402 --HVLELEAKMDQL-----------RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE 448
Query: 369 SRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEE 428
S D +TK E A K+ ++ S L E+ A +++ + ++ V ++ + +E E
Sbjct: 449 SITKGDLETQTKLEHARIKE---LEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELE 505
Query: 429 LEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRL------TRAENRIKQLETDSS 482
+ R +++ E+ +R L S + D+ + L + + +++ TD
Sbjct: 506 KDLALR--------VQEVAELRRR-LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ 556
Query: 483 EEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALE--AQKK 540
EI+ +E + + E + +E KL +EN+ L+ + E K + A K
Sbjct: 557 REITSLKEHFGAREETHQKEIKALYTATE---KLSKENESLKSKLEHANKENSDVIALWK 613
Query: 541 AKVKISTMEHEFSIKE------RGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEE 594
+K++ + H+ +++E +G + E + + I ++R L Q + N ++
Sbjct: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMR--LDYQHEIENLQNQQ 670
Query: 595 TKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQR- 653
+ A+ + L+++L + + L + +K AE++ L+ E ++ N+LQ
Sbjct: 671 DSERAAHAK-EMEALRAKLMKVIKEKENSLEAIRSKLDK-AEDQHLV-EMEDTLNKLQEA 727
Query: 654 --RLSQAEERAASASQQLSVI 672
++ + E A ++Q VI
Sbjct: 728 EIKVKELEVLQAKCNEQTKVI 748
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 116 bits (290), Expect = 8e-26
Identities = 162/748 (21%), Positives = 321/748 (42%), Gaps = 91/748 (12%)
Query: 4 EIDFLREQNRRLNEDF----RRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPL 59
+I L ++N LN+ +R Q+ + ++ ++K E E++ S L+ +
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK-----ENKILHESIKETSSKLSKI 606
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVI----KENERLHSELKDA--VEKKLEAF 113
E++K ++ +L++Y K+ GE +LEN + KENE L ++ + +K+EA
Sbjct: 607 --EFEKR--QIKKELEHY-KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEAL 661
Query: 114 PLGTEVGTDIYADD-------ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQ 166
+ +++ ++ ++ +NL QL+ +E +Q E + + ++ L K
Sbjct: 662 E---QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL-KCAS 717
Query: 167 EHMTEAQIHVFESQKQKDQLFDFQQL-------TKQLHVTNENMEVTNQQFLKTVTEQSV 219
M + Q+ E + +K+QL +L T++L V+ + +++ NQ+ KT+ +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 220 IIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQ 279
I+QL +L+ ++E + +EEL ++ L+ Q++K+ K + + E ++L++
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELKISSKRLE-QLEKENKSLEQETSQLEKDKKQLEK 836
Query: 280 LQSSIKQLEIRLCVTIQEAN----QLRTENTHLEKQT---RELQAKCNELENERYEAIVR 332
++Q T++E N L EN L K+ +E + ELE E E + R
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 333 ARNSMQLLEEANLQKSQALLEEKQKEEDIEKM----------KETVSRFVQDATIRTKKE 382
A ++ L L+ +Q D+EK+ KE + Q R K
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 383 VANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYRE------- 435
+ + + E+++AL+ E +++ +E K V++ E + +
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 436 -------------GRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSS 482
R ++ R+L ++ R + ER+ LQ + ++KQLET +
Sbjct: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN- 1075
Query: 483 EEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAK 542
+ Q I LQ S +E + Q KLQ EN L ++ SL + AQ +
Sbjct: 1076 ---NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL--MNQNAQLLIQ 1130
Query: 543 VKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESA 602
E+E IKER L + + + L A++ ++ K ++
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 603 EIRINNLK---SELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAE 659
E+ +L+ ++L +QK ++L L++ EK+ K H+ A ++ + +
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK---NHETVAAEYKKLCGEND 1247
Query: 660 ERAASASQQL---SVITVQRRKAASLMN 684
+ SQ L V+ + SL+N
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLN 1275
Score = 104 bits (260), Expect = 2e-22
Identities = 128/636 (20%), Positives = 282/636 (44%), Gaps = 82/636 (12%)
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY 124
+ L E QL ++++ +M+++L+ + +EN L S+ + A + E L +
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 125 ADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKD 184
+ E R +E+ +E ++ +EL +++ E T + + ++ + D
Sbjct: 325 LESEVSRY---------KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSD 375
Query: 185 QLFDFQQLTKQLHVTNENMEV---TNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAK 241
+L + ++ QL +ME+ +++ ++ + E+++ +E +K+ L L + +
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 242 VEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQL-----EIRLCVTIQ 296
+ + ++E Q + H E + RL +L+ + L E+R V
Sbjct: 436 ISRTSELSEAPQKSL---------GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 297 EANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQ---------LLEEANLQK 347
E N ++ +EK+ + L K LENE IV+ + S+Q + E+A L+K
Sbjct: 487 EGN--ASKILKMEKENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 348 SQALLEEKQK------EEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL 401
+ L E + E++ E + +TVS Q + I + V + +K+ I
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI--------- 591
Query: 402 SALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKD 461
L E ++ ++ EK+ +++ELE +G + EE+ E+ +
Sbjct: 592 --LHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKENE 642
Query: 462 DLQLRLTRAE---NRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQ 518
LQ ++T + +I+ LE ++S E+ R ++K + ++ + ++ +L +
Sbjct: 643 LLQKKITNLKITCEKIEALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 519 ENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELR 578
EN +LR+ ESL K A + +++ +E E ++G E+ + + R
Sbjct: 702 ENLELRRNVESL-KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER------- 753
Query: 579 HLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQEL---LSQLEMANEKVA 635
L + + + +K E++ +I L+SEL ++ Q L L +L+++++++
Sbjct: 754 --LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 636 ENEKLILEHQEKANRLQRRLSQAEERAASASQQLSV 671
+ EK +++ ++L++ Q E+ QQ +
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Score = 75.9 bits (185), Expect = 1e-13
Identities = 111/609 (18%), Positives = 273/609 (44%), Gaps = 57/609 (9%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLV 60
+ +E+ L +N+ L ++ ++ S K + Q E ++ ++L + S L
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISS--------KRLEQLEKEN--KSLEQETSQLEKDK 831
Query: 61 TEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSEL---KDAVEKKLEAFPLGT 117
+ +K L Q + + E +++ N+ KEN+ L E+ K++ + E
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 118 EVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRL-----HKLYQEHMTEA 172
E+ D +T+ L+E L + Q + ++ EL+++ L+ E T+
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 173 QIHVFESQKQ---KDQLFDFQQLTKQLHVTNENMEVTNQQF---LKTVTEQSVIIEQLRK 226
+ + ES+ + K L ++ L E NQQ LKTV + ++Q +
Sbjct: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD 1011
Query: 227 KLRQAKLELRVA------VAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQL 280
+ R + ++ + +E T ++ ++ + E++ + ++A +L+QL
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1071
Query: 281 QSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLL 340
++ L+ ++ ++ L+ +NT L+ Q +LQ + + L ++ + +N+ L+
Sbjct: 1072 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ--STSLMNQNAQLLI 1129
Query: 341 EEANLQ-KSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTE 399
++++L+ +++++++E+ ED++ + +++ + + + +++ + + + + L
Sbjct: 1130 QQSSLENENESVIKER---EDLKSLYDSLIKDHEKLELLHERQASEYESLIS-KHGTLKS 1185
Query: 400 ELSALQMECAEKQGQIERVIKEKKAVEE-------ELEKIYREGRGNES---DYRKL--- 446
L++E + + + +++K+K +E+ E EK+ E + +E+ +Y+KL
Sbjct: 1186 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1245
Query: 447 -EEMHQRFLVSERSKDDLQL---RLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESE 502
+ ++ + + + LQ L N K +T E S+ +E Q+L
Sbjct: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1305
Query: 503 RENCGLVSEQRLKLQQENKQLRKETESL---RKIALEAQKKAKVKISTMEHEFSIKERGF 559
C L+S+ + L++EN+ L + ++L + LE ++K + ++ K
Sbjct: 1306 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 560 EVQLREMED 568
Q ++E+
Sbjct: 1366 RRQKEKLEE 1374
Score = 63.5 bits (153), Expect = 6e-10
Identities = 108/490 (22%), Positives = 210/490 (42%), Gaps = 49/490 (10%)
Query: 198 VTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMK 257
VT+ V + Q+++ VT+ S E + L+ L L+ + + +E + +L
Sbjct: 163 VTHNQENVFDLQWME-VTDMSQ--EDIEPLLKNMALHLKRLIDERDEHSETIIELS---- 215
Query: 258 KKEKDVVSAHGREEASDRRLQQLQS-SIKQLEIRLCVTIQEAN---QLRTENTHLEKQTR 313
+E+D H AS S +K+ E R ++++ A+ ++R LE++T
Sbjct: 216 -EERD--GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
Query: 314 ELQAKCNELENERYEAIVRARNSMQLLEEANLQKS--QALLEEKQKEEDIEKMKETVSRF 371
+L ELE E + +M LL +A + L ++K ++K++ VSR+
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 372 VQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK 431
KE + + ++ L E+ L E + +E ++ +A ++L +
Sbjct: 333 ---------KERLHDIEFYKARVEELKEDNQVL----LETKTMLEDQLEGTRARSDKLHE 379
Query: 432 IYREGRGNESDYR--KLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETD-SSEEISRY 488
+ +E ++ ++E R + E ++++ L + + ++ + L E+ISR
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 489 QEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTM 548
E+ + Q L E L S + LKL+ EN+ L K E LR + A KI M
Sbjct: 440 SELSEAPQKSLGHEVNE--LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS-KILKM 496
Query: 549 EHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINN 608
E E + E+ E+ + S+ ++L K + ++ + L E++E +I
Sbjct: 497 EKENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555
Query: 609 LKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQ 668
L+ E H + +S L ++ AE ++ EK N++ E S +
Sbjct: 556 LEQE----NEHLNQTVSSLRQRSQISAEAR---VKDIEKENKI------LHESIKETSSK 602
Query: 669 LSVITVQRRK 678
LS I ++R+
Sbjct: 603 LSKIEFEKRQ 612
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 116 bits (290), Expect = 8e-26
Identities = 153/704 (21%), Positives = 299/704 (42%), Gaps = 83/704 (11%)
Query: 8 LREQNRRLNEDFRRYQMESFSKYSSV-----QKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
L + +R L + Y+++ S+ Q+A Q E + L ++ ++ L
Sbjct: 1247 LEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT-- 1304
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
G+L Y Q Q+ ++K QLE + K+A+ L++ ++ +
Sbjct: 1305 --------RGKLSYTQ-QMEDLKRQLEE--------EGKAKNALAHALQSARHDCDLLRE 1347
Query: 123 IYADD-ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
Y ++ E LQ L AN E Q W+T E D + + E + EA+ +K
Sbjct: 1348 QYEEETEAKAELQRVLSKANSEVAQ----WRT-KYETDAIQRT--EELEEAK------KK 1394
Query: 182 QKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQ-------LRKKLRQAKLE 234
+L D ++ + ++ ++E T + + + V +E+ L KK R
Sbjct: 1395 LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1454
Query: 235 LRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVT 294
L K EE + E Q + + ++ E S L+ + K L+ +
Sbjct: 1455 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1514
Query: 295 IQEANQLRTENTHLEKQTRELQAKCNELEN--ERYEAIVRARNSMQLLEEANLQKSQALL 352
++ + LEK ++L+ + EL++ E EA + L + + +A +
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1574
Query: 353 EEK--QKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRLTEELSAL 404
E K +K+E++E+ K R V DA R++ EV KK+ ++ + +LS
Sbjct: 1575 ERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHA 1634
Query: 405 QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQ 464
AE Q Q++ + K + +L+ R +++ + + ER + LQ
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN----------DDLKENIAIVERRNNLLQ 1684
Query: 465 LRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLR 524
L ++Q T+ S +++ QE+I+ + V +N L++ Q+ K++ + QL+
Sbjct: 1685 AELEELRAVVEQ--TERSRKLAE-QELIETSERVQLLHSQNTSLIN-QKKKMESDLTQLQ 1740
Query: 525 KETESLRKIALEAQKKAKVKI--STMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLL- 581
E E + A++KAK I + M E KE+ L M+ + +I +L+H L
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1800
Query: 582 ATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV------- 634
+Q A K++ +KL E R+ L+ EL ++ E + + + ++
Sbjct: 1801 EAEQIALKGGKKQLQKL----EARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQT 1856
Query: 635 AENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRK 678
E++K +L Q+ ++LQ ++ + +A A +Q + + RK
Sbjct: 1857 EEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1900
Score = 94.4 bits (233), Expect = 3e-19
Identities = 132/630 (20%), Positives = 261/630 (41%), Gaps = 95/630 (15%)
Query: 80 QVGEMKLQLENVIKE-NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQ 138
Q+ + K+QLE +KE NERL E + E + L E +++ D + +L+ L
Sbjct: 909 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC-SELKKD---IDDLELTLA 964
Query: 139 LANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHV 198
+EK + +++E+ L ++ + E + Q+ D L + L
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024
Query: 199 TNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKK 258
+ +E ++ ++ + L + R+ + +L++ + +L N L+ ++KK
Sbjct: 1025 SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Query: 259 KEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAK 318
KE D+ + + E QLQ +K+ + R+ +E RT +EK +L +
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR 378
E+ + LEEA S + K++E + +KM+ R +++AT++
Sbjct: 1145 LEEIS--------------ERLEEAGGATSVQIEMNKKREAEFQKMR----RDLEEATLQ 1186
Query: 379 TKKEVANTKKQCNIQISRLTEELSALQ--------------MECAEKQGQIERVIKEKKA 424
+ A +K+ ++ L E++ LQ +E + +E++IK K
Sbjct: 1187 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK-- 1244
Query: 425 VEEELEKIYREGRGNESDYR-KLEEMHQRF--LVSERSK-----DDLQLRLTRAENRIKQ 476
LEK+ R ++YR KLEE + ++R+K +L +L E I Q
Sbjct: 1245 --ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ 1302
Query: 477 LE------TDSSEEISRYQEMIQKLQN----VLESERENCGLVSEQRLKLQQENKQLRKE 526
L T E++ R E K +N L+S R +C L+ EQ +E + + E
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ----YEEETEAKAE 1358
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQK 586
+ + A + + K T ++I L ++K
Sbjct: 1359 LQRVLSKANSEVAQWRTKYET------------------------DAIQRTEELEEAKKK 1394
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMAN-------EKVAENEK 639
A R ++ ++ E+ + ++L+ R + ++L+ +E +N +K +K
Sbjct: 1395 LAQR-LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1453
Query: 640 LILEHQEKANRLQRRLSQAEERAASASQQL 669
++ E ++K Q L +++ A S S +L
Sbjct: 1454 ILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Score = 83.6 bits (205), Expect = 6e-16
Identities = 98/526 (18%), Positives = 226/526 (42%), Gaps = 41/526 (7%)
Query: 2 AAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVT 61
AA +D + ++ ++++ ES S+ S QK +L + L
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEA---------RSLSTELFKLKNAYE 1491
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E +HL + K Q+++ ++ QL K L K +KLE E
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551
Query: 122 DIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
+ + E + L+ QL+ NQ K + +E+++ + +Q + Q + +
Sbjct: 1552 SL--EHEEGKILRAQLEF-NQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Query: 182 QKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAK 241
++++ ++ K++ ME+ + E ++ L+ L+ +++L AV
Sbjct: 1609 SRNEVL---RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV-- 1663
Query: 242 VEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQL 301
+DL+ + E+ E ++Q + S K E L T + L
Sbjct: 1664 -----RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 302 RTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED- 360
++NT L Q +++++ +L++E EA+ RN+ + ++A + + + EE +KE+D
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDT 1777
Query: 361 ---IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIER 417
+E+MK+ + + ++D R + K Q+ +L + L+ E +Q +
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 418 VIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQL 477
+K + E ++++ + ++ + +L+++ D LQL++ + + ++
Sbjct: 1838 SVKGMRKSERRIKELTYQTEEDKKNLLRLQDL----------VDKLQLKVKAYKRQAEEA 1887
Query: 478 ETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQL 523
E ++ +S++ +K+Q+ L+ E + Q KL+ +++ +
Sbjct: 1888 EEQANTNLSKF----RKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Score = 74.3 bits (181), Expect = 3e-13
Identities = 98/463 (21%), Positives = 200/463 (43%), Gaps = 63/463 (13%)
Query: 256 MKKKEKDVVSAHGREEAS--DRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTR 313
+K E + A +EE L++ ++ K+LE ++ +QE N L+ + +
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 314 ELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQ 373
+ + +C++L + + + + + LE+ ++ ++++ E++ ++K+ +
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI----- 956
Query: 374 DATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIY 433
D T +V K ++ LTEE++ L I ++ KEKKA++E ++
Sbjct: 957 DDLELTLAKVEKEKHATENKVKNLTEEMAGL-------DEIIAKLTKEKKALQEAHQQAL 1009
Query: 434 REGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSE---EISRYQE 490
+ + E K+ + + + E+ DDL+ L + + LE + ++ QE
Sbjct: 1010 DDLQVEED---KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1066
Query: 491 MIQKLQN------------VLESERENCGLVSEQ--RLKLQQENKQLRKETESLRKIALE 536
I L+N + ++N + EQ L+LQ++ K+ + E L + LE
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEE-ELE 1125
Query: 537 AQKKAKVKISTMEHEFS---------IKERGFEVQLR-EMEDSNRNSIVELRHLL--ATQ 584
A++ A+ K+ + + S ++E G ++ EM ++R L AT
Sbjct: 1126 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1185
Query: 585 QKAANRWKEETKKLTESAEI--RINN-------LKSELSRQKLHTQELLSQLEMANEKVA 635
Q A K AE+ +I+N L+ E S KL ++ S +E + A
Sbjct: 1186 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
Query: 636 ENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRK 678
EK+ +++AN + +L +A+ + L+ T QR K
Sbjct: 1246 NLEKVSRTLEDQANEYRVKLEEAQ-------RSLNDFTTQRAK 1281
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 115 bits (288), Expect = 1e-25
Identities = 164/761 (21%), Positives = 307/761 (40%), Gaps = 146/761 (19%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQ---------MESFSKYSSVQKAVCQGEGDDTFENLVF 51
+ +ID L+ ++L ++ ++ MES SK + + +C+ D E
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 52 DQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLE 111
++ E + L EL Q Q + GE+ QLE E E + S+L + +
Sbjct: 1264 NE--------EIQRSLSELTTQKSRLQTEAGELSRQLE----EKESIVSQLS----RSKQ 1307
Query: 112 AFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTE 171
AF TE L+ QL+ N+ K Q+ + D L + Y+
Sbjct: 1308 AFTQQTE-------------ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYE----- 1349
Query: 172 AQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQ- 230
E Q+ K +L + L N + ++ +++ +E+ +KKL Q
Sbjct: 1350 ------EEQEGK------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1397
Query: 231 ---AKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRR-------LQQL 280
++ ++ AK L + LQG+++ DV A+ A D++ L +
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 281 QSSIKQLEIRLCVTIQEANQLRT---------------------ENTHLEKQTRELQAK- 318
++ ++ + L +++E+ L T EN +LE++ +L +
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 1517
Query: 319 ------CNELENERYEAIVRARNSMQLLEEANLQ------------------KSQALLEE 354
+ELE R + + + LEEA KS+ +
Sbjct: 1518 AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKI 1577
Query: 355 KQKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRLTEELSALQMEC 408
+K+E+IE++K R V+ DA +R++ E KK+ ++ + +LS +
Sbjct: 1578 AEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 409 AEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLT 468
AE + V + K + L+ RG E +L + +R + + ++L+ L
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDAL---RGQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Query: 469 RAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETE 528
+ E K E QE++ + V +N L+ ++ KL+ + QL+ E E
Sbjct: 1695 QTERARKLAE----------QELLDSNERVQLLHTQNTSLIHTKK-KLETDLMQLQSEVE 1743
Query: 529 SLRKIALEAQKKAKVKI--STMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLL-ATQQ 585
+ A A++KAK I + M E KE+ L M+ + ++ +L+H L +Q
Sbjct: 1744 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
Query: 586 KAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV-------AENE 638
A K++ +KL E RI L+ EL ++ E + L +V E+
Sbjct: 1804 LALKGGKKQIQKL----ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDR 1859
Query: 639 KLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKA 679
K +L Q+ ++LQ ++ + +A A +Q + + RKA
Sbjct: 1860 KNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900
Score = 101 bits (252), Expect = 2e-21
Identities = 153/686 (22%), Positives = 281/686 (40%), Gaps = 120/686 (17%)
Query: 80 QVGEMKLQLENVIKE-------NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Q+ + K QLE IKE E +++EL A ++KLE +E+ DI DD
Sbjct: 908 QLIKAKFQLEAKIKEVTERAEDEEEINAELT-AKKRKLE--DECSELKKDI--DD----- 957
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
L+ L +EK + +++EL L + + E + Q+ D L +
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
L+ T +E + ++ ++ + L + R+ + +L++A + +L N + L
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
++KKK+ + + E Q Q IK+L+ R+ +E R EKQ
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137
Query: 313 RELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFV 372
+ + EL + LEEA S + K++E + K++ R +
Sbjct: 1138 SDYARELEELS--------------ERLEEAGGVTSTQIELNKKREAEFLKLR----RDL 1179
Query: 373 QDATIRTKKEVANTKKQCNIQISRLTEELSALQ--------------MECAEKQGQIERV 418
++AT++ + VA +K+ ++ L E++ LQ +E + +E V
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 419 IKEKKAVEE---ELEKIYREGRG-NESDYRKLEEMHQRFLVSERSKDDLQLRLTRAE--- 471
K K +E+ LE E RG NE R L E+ + + +L +L E
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Query: 472 ---NRIKQLETDSSEEISRYQEMIQKLQN----VLESERENCGLVSEQRLKLQQENKQLR 524
+R KQ T +EE+ R E K +N L+S R +C L+ EQ + Q+ +L+
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 525 K----------------ETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMED 568
+ ET+++++ E ++AK K++ + + + +E
Sbjct: 1360 RALSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Query: 569 SNRNSIVELRHLLATQQKAAN-----------------RWK---EETKKLTESAEIRINN 608
+ + E+ L+ ++A + WK EE++ E++ +
Sbjct: 1418 TKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Query: 609 LKSELSRQKLHTQELLSQLEMA--------------NEKVAENEKLI--LEHQEKANRLQ 652
L +EL + K +E L QLE E++AEN K I LE K L+
Sbjct: 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELE 1537
Query: 653 R---RLSQAEERAASASQQLSVITVQ 675
+ +L+ E AA ++ ++ +Q
Sbjct: 1538 KADIQLALEEAEAALEHEEAKILRIQ 1563
Score = 99.0 bits (245), Expect = 1e-20
Identities = 151/714 (21%), Positives = 311/714 (43%), Gaps = 103/714 (14%)
Query: 59 LVTEYDKHLGELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPL 115
L + +++ +L G LK Q+ + ++ K QL+ +K+ + + +L+ VE + L
Sbjct: 1045 LRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE---DEQTL 1101
Query: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--HMTEAQ 173
G + I + L+E+++ + + + ++EL+ L + +E +T Q
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161
Query: 174 IHVFESQKQKDQLF-----DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKL 228
I E K+++ F D ++ T Q + + + + EQ ++++++KL
Sbjct: 1162 I---ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKL 1218
Query: 229 RQAKLELRVAV----AKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSI 284
+ K E ++ + + +E ++ +L+ + E + A G+ E R L +L +
Sbjct: 1219 EKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQK 1278
Query: 285 KQLEI---RLCVTIQE----ANQLRTENTHLEKQTRELQAKC---NELENERYEAIVRAR 334
+L+ L ++E +QL +QT EL+ + N+ +N A+ +R
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Query: 335 NSMQLLEE---------ANLQKSQALLEEK-------------QKEEDIEKMKETVSRFV 372
+ LL E A LQ++ + + Q+ E++E+ K+ +++ +
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398
Query: 373 QDATIRTK------KEVANTKKQCNIQISRL---TEELSALQMECAEKQGQIERVIKEKK 423
QD+ + + + TK++ ++ L E ++L +KQ ++V+ E K
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458
Query: 424 A----VEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENR-IKQLE 478
+ ELE +E R ++ KL+ ++ L QL + EN+ ++Q
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALD--------QLETVKRENKNLEQEI 1510
Query: 479 TDSSEEISRYQEMIQKLQNVLESERENCGL-VSEQRLKLQQENKQLRKETESLRKIALE- 536
D +E+I+ + I + LE R+ L ++ +L L++ L E + +I LE
Sbjct: 1511 ADLTEQIAENGKTIHE----LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 537 AQKKAKV--KISTMEHEFSIKERGFEVQLREMEDS------NRNSIVELR-------HLL 581
Q K+++ KI+ + E +R ++ + M+ + +RN + L+ + +
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI 1626
Query: 582 ATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM----ANEKVAEN 637
Q ANR ET K S + ++ + + L ++L QL + AN AE
Sbjct: 1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV 1686
Query: 638 EKL--ILEHQEKANRL--QRRLSQAEERAASASQQLSVITVQRRKAASLMNLEN 687
E+L LE E+A +L Q L E +Q S+I +++ LM L++
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Score = 86.7 bits (213), Expect = 7e-17
Identities = 106/536 (19%), Positives = 239/536 (44%), Gaps = 61/536 (11%)
Query: 28 SKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQ 87
+K +S++K + +G+ E+L+ D L DK + L ++ + E + +
Sbjct: 1410 AKCASLEKTKQRLQGE--VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467
Query: 88 LENVIKENERLHSEL---KDAVEKKLEAFP--------LGTEVGT---DIYADDETVRNL 133
LE +KE+ L +EL K+A E+ L+ L E+ I + +T+ L
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 134 QE---QLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQ 190
++ Q++L + A+E + + + Q +T+ + + +KD+ + +
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE--EIE 1585
Query: 191 QLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTE 250
QL + T E M+ +++ E + +++ L + +++L A + E
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLR 1645
Query: 251 DLQGQMKKKEKDVVSA-HGREEASD------RRLQQLQSSIKQLEIRLCVT--------- 294
+QGQ+K + + A G+E+ + RR LQ+ +++L L T
Sbjct: 1646 SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQ 1705
Query: 295 -IQEANQ----LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQ 349
+ ++N+ L T+NT L ++L+ +L++E +A ARN+ + ++A + +
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKA-ITDAA 1764
Query: 350 ALLEEKQKEED----IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQ 405
+ EE +KE+D +E+MK+ + + V+D R + K QI +L + L+
Sbjct: 1765 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824
Query: 406 MECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQL 465
E +Q + +K + E ++++ + + + +L+++ D LQ+
Sbjct: 1825 FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL----------VDKLQV 1874
Query: 466 RLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENK 521
++ + + ++ + ++ ++++ +K Q+ LE E + Q KL+ + +
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKF----RKAQHELEEAEERADIAESQVNKLRAKTR 1926
Score = 81.6 bits (200), Expect = 2e-15
Identities = 103/513 (20%), Positives = 220/513 (42%), Gaps = 65/513 (12%)
Query: 199 TNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKK 258
T + M ++F KT E + E RK+L + K+ L DLQ Q++
Sbjct: 846 TEKEMATMKEEFQKTKDELAKS-EAKRKELEE----------KLVTLVQEKNDLQLQVQA 894
Query: 259 KEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAK 318
+ ++++ A R + + QL++ IK++ + A N L + R+L+ +
Sbjct: 895 ESENLLDAEERCDQLIKAKFQLEAKIKEV-------TERAEDEEEINAELTAKKRKLEDE 947
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE--EDIEKMKETVSRFVQDAT 376
C+EL+ + + L A ++K + E K K E++ + ET+++
Sbjct: 948 CSELKKDIDDL---------ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT---- 994
Query: 377 IRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERV---IKEKKAVEEELEKIY 433
R KK + +Q + +++++L ++ + Q+E + ++++K + +LE+
Sbjct: 995 -REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK 1053
Query: 434 REGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEE--------- 484
R+ G+ L+ + L E K L RL + + QL++ +E
Sbjct: 1054 RKLEGD------LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQK 1107
Query: 485 -ISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETE---SLRKIALEAQKK 540
I Q I++L+ +E+ER +QR +E ++L + E + +E KK
Sbjct: 1108 KIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167
Query: 541 AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTE 600
+ + + + E + + + +S+ EL + Q R K++ +K
Sbjct: 1168 REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ----RVKQKLEKEKS 1223
Query: 601 SAEIRINNLKSEL---SRQKLHTQELLSQLE-MANEKVAENEKLILEHQEKANRLQRRLS 656
++ I++L S + S+ K + +++ LE +E +NE++ E + R +
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 657 QAEERAASASQQLSVIT-VQRRKAASLMNLENI 688
+A E + ++ S+++ + R K A E +
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEEL 1316
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 115 bits (288), Expect = 1e-25
Identities = 159/749 (21%), Positives = 327/749 (43%), Gaps = 92/749 (12%)
Query: 4 EIDFLREQNRRLNEDF----RRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPL 59
+I L ++N LN+ +R Q+ + ++ ++K E E++ S L+ +
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK-----ENKILHESIKETSSKLSKI 606
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVI----KENERLHSELKDA--VEKKLEAF 113
E++K ++ +L++Y K+ GE +LEN + KENE L ++ + +K+EA
Sbjct: 607 --EFEKR--QIKKELEHY-KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEAL 661
Query: 114 PLGTEVGTDIYADD-------ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQ 166
+ +++ ++ ++ +NL QL+ +E +Q E + + ++ L K
Sbjct: 662 E---QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL-KCAS 717
Query: 167 EHMTEAQIHVFESQKQKDQLFDFQQL-------TKQLHVTNENMEVTNQQFLKTVTEQSV 219
M + Q+ E + +K+QL +L T++L V+ + +++ NQ+ KT+ +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 220 IIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQ 279
I+QL +L+ ++E + +EEL ++ L+ Q++K+ K + + E ++L++
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELKISSKRLE-QLEKENKSLEQETSQLEKDKKQLEK 836
Query: 280 LQSSIKQLEIRLCVTIQEAN----QLRTENTHLEKQT---RELQAKCNELENERYEAIVR 332
++Q T++E N L EN L K+ +E + ELE E E + R
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 333 ARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRF---------VQDATIRTKKEV 383
A ++ L L+ +Q D+EK+ + + + +T ++ ++
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 384 ANTKKQCNIQ--ISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYRE------ 435
+K + ++ + E+++AL+ E +++ +E K V++ E + +
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 436 --------------GRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDS 481
R ++ R+L ++ R + ER+ LQ + ++KQLET +
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1076
Query: 482 SEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKA 541
+ Q I LQ S +E + Q KLQ EN L ++ SL + AQ
Sbjct: 1077 ----NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL--MNQNAQLLI 1130
Query: 542 KVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTES 601
+ E+E IKER L + + + L A++ ++ K ++
Sbjct: 1131 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1190
Query: 602 AEIRINNLK---SELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQA 658
E+ +L+ ++L +QK ++L L++ EK+ K H+ A ++ +
Sbjct: 1191 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK---NHETVAAEYKKLCGEN 1247
Query: 659 EERAASASQQL---SVITVQRRKAASLMN 684
+ + SQ L V+ + SL+N
Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276
Score = 104 bits (260), Expect = 2e-22
Identities = 128/636 (20%), Positives = 282/636 (44%), Gaps = 82/636 (12%)
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY 124
+ L E QL ++++ +M+++L+ + +EN L S+ + A + E L +
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 125 ADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKD 184
+ E R +E+ +E ++ +EL +++ E T + + ++ + D
Sbjct: 325 LESEVSRY---------KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSD 375
Query: 185 QLFDFQQLTKQLHVTNENMEV---TNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAK 241
+L + ++ QL +ME+ +++ ++ + E+++ +E +K+ L L + +
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 242 VEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQL-----EIRLCVTIQ 296
+ + ++E Q + H E + RL +L+ + L E+R V
Sbjct: 436 ISRTSELSEAPQKSL---------GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 297 EANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQ---------LLEEANLQK 347
E N ++ +EK+ + L K LENE IV+ + S+Q + E+A L+K
Sbjct: 487 EGN--ASKILKMEKENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 348 SQALLEEKQK------EEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL 401
+ L E + E++ E + +TVS Q + I + V + +K+ I
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI--------- 591
Query: 402 SALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKD 461
L E ++ ++ EK+ +++ELE +G + EE+ E+ +
Sbjct: 592 --LHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKENE 642
Query: 462 DLQLRLTRAE---NRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQ 518
LQ ++T + +I+ LE ++S E+ R ++K + ++ + ++ +L +
Sbjct: 643 LLQKKITNLKITCEKIEALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 519 ENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELR 578
EN +LR+ ESL K A + +++ +E E ++G E+ + + R
Sbjct: 702 ENLELRRNVESL-KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER------- 753
Query: 579 HLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQEL---LSQLEMANEKVA 635
L + + + +K E++ +I L+SEL ++ Q L L +L+++++++
Sbjct: 754 --LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 636 ENEKLILEHQEKANRLQRRLSQAEERAASASQQLSV 671
+ EK +++ ++L++ Q E+ QQ +
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Score = 73.9 bits (180), Expect = 4e-13
Identities = 123/602 (20%), Positives = 258/602 (42%), Gaps = 98/602 (16%)
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKL---QLENVIKENERLHSEL------KDAVEKKL 110
+ + + L +L + + QK + E+K+ +LE + KEN+ L E K +EK+
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 111 EAFPLGTEV-GTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHM 169
+ E+ T + ++ + NL+++ N+ ++ + +++ L L K +E +
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKE----NKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 170 TEAQIHV---------FESQKQKDQLF--DFQQLTKQLHVTNENMEVTNQQFLKTVTEQS 218
A I + S+K K Q D ++LT +L N E T +
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 219 VIIEQ-----LRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEAS 273
++E L+K L + ++ A++EE TN + L+ ++K +K+ + R++
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 274 ----------------DRRLQQLQSSIKQLEIRLC------VTIQEANQ-LRTENTHLEK 310
+R Q+ + +++ RL T+Q Q L+T+ LE
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1074
Query: 311 QTRELQAKCNELENE-----RYEAIVRARNSMQLLEEANL---------QKSQALLEEKQ 356
Q LQA+ L+ + ++ +N+ +E + L Q +Q L+++
Sbjct: 1075 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134
Query: 357 KE---EDIEKMKETVSRFVQDATIRT--KKEVANTKKQCNIQ--ISRLTEELSA---LQM 406
E E + K +E + + + D+ I+ K E+ + ++ + IS+ SA L++
Sbjct: 1135 LENENESVIKEREDL-KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1193
Query: 407 ECAEKQGQIERVIKEKKAVEE-------ELEKIYREGRGNES---DYRKL----EEMHQR 452
E + + + +++K+K +E+ E EK+ E + +E+ +Y+KL + ++
Sbjct: 1194 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 453 FLVSERSKDDLQL---RLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLV 509
+ + + LQ L N K +T E S+ +E Q+L C L+
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
Query: 510 SEQRLKLQQENKQLRKETESL---RKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREM 566
S+ + L++EN+ L + ++L + LE ++K + ++ K Q ++
Sbjct: 1314 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1373
Query: 567 ED 568
E+
Sbjct: 1374 EE 1375
Score = 63.5 bits (153), Expect = 6e-10
Identities = 108/490 (22%), Positives = 210/490 (42%), Gaps = 49/490 (10%)
Query: 198 VTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMK 257
VT+ V + Q+++ VT+ S E + L+ L L+ + + +E + +L
Sbjct: 163 VTHNQENVFDLQWME-VTDMSQ--EDIEPLLKNMALHLKRLIDERDEHSETIIELS---- 215
Query: 258 KKEKDVVSAHGREEASDRRLQQLQS-SIKQLEIRLCVTIQEAN---QLRTENTHLEKQTR 313
+E+D H AS S +K+ E R ++++ A+ ++R LE++T
Sbjct: 216 -EERD--GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
Query: 314 ELQAKCNELENERYEAIVRARNSMQLLEEANLQKS--QALLEEKQKEEDIEKMKETVSRF 371
+L ELE E + +M LL +A + L ++K ++K++ VSR+
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 372 VQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK 431
KE + + ++ L E+ L E + +E ++ +A ++L +
Sbjct: 333 ---------KERLHDIEFYKARVEELKEDNQVL----LETKTMLEDQLEGTRARSDKLHE 379
Query: 432 IYREGRGNESDYR--KLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETD-SSEEISRY 488
+ +E ++ ++E R + E ++++ L + + ++ + L E+ISR
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 489 QEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTM 548
E+ + Q L E L S + LKL+ EN+ L K E LR + A KI M
Sbjct: 440 SELSEAPQKSLGHEVNE--LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS-KILKM 496
Query: 549 EHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINN 608
E E + E+ E+ + S+ ++L K + ++ + L E++E +I
Sbjct: 497 EKENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555
Query: 609 LKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQ 668
L+ E H + +S L ++ AE ++ EK N++ E S +
Sbjct: 556 LEQE----NEHLNQTVSSLRQRSQISAEAR---VKDIEKENKI------LHESIKETSSK 602
Query: 669 LSVITVQRRK 678
LS I ++R+
Sbjct: 603 LSKIEFEKRQ 612
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 112 bits (280), Expect = 1e-24
Identities = 156/718 (21%), Positives = 299/718 (41%), Gaps = 108/718 (15%)
Query: 3 AEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
A+ID L +NR L+E+ +R + ++++ E + Q V++
Sbjct: 1393 AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRV----------EEDIQQQKATGSEVSQ 1442
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVE------KKLEAFP-- 114
+ QL+ +QV +M+ + E+ R L DA + K++E
Sbjct: 1443 RKQ-------QLEVELRQVTQMRTE------ESVRYKQSLDDAAKTIQDKNKEIERLKQL 1489
Query: 115 LGTEVGTDIYADDETVR--NLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEA 172
+ E +DE R +Q LQ AN T+ + + QEL RL Y+
Sbjct: 1490 IDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYE------ 1543
Query: 173 QIHVFESQKQKDQ-LFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQA 231
V + + KDQ + FQ K+L + + +E + +T +E S ++L ++L
Sbjct: 1544 --RVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601
Query: 232 KLELRVAVAKVEELTNVTEDLQGQMKKKE------KDVVSAHGRE-EASDRRLQQLQSSI 284
+ L+ K+ LT E K+ E +DV+ H RE + + L++L S +
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661
Query: 285 KQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNE--LENERYEAIVRARNSMQLLEE 342
+ L +L + Q N H +K + NE +E ER +++
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE---------- 1711
Query: 343 ANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELS 402
NL K +LEE+ + +E D R + E + K N I L +L
Sbjct: 1712 -NLTKEHLMLEEELRNLRLE----------YDDLRRGRSEADSDK---NATILELRSQLQ 1757
Query: 403 ALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDD 462
E QG I + +E++ + +E+EK ++ E+ R E +Q V + +
Sbjct: 1758 ISNNRTLELQGLINDLQRERENLRQEIEKFQKQAL--EASNRIQESKNQCTQVVQERESL 1815
Query: 463 LQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESE-----RENCGLVSEQRLKLQ 517
L +IK LE D + + R ++ + + ++ LE+E R C Q L
Sbjct: 1816 LV--------KIKVLEQDKA-RLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN-DLN 1865
Query: 518 QENKQLRKETESLRKIALEAQKKAKVK---ISTMEHEFSIKERGFEVQLREMEDSNRNSI 574
Q Q ++ E++RKI E +K + K S +E + +R E R++EDS R +
Sbjct: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ 1925
Query: 575 VELRHLLATQQKAANRWKE-----------ETKKLTESAEIRINNLKSELSRQKLHTQEL 623
+L + Q+ ++ ++ E + +++++ + L+ +++ +L+ +L
Sbjct: 1926 SQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQL 1985
Query: 624 LSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAAS 681
+ + + +K+ + +K + E + R +AS ++ S++ +R+K S
Sbjct: 1986 IDKTTL--DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLIS 2041
Score = 99.4 bits (246), Expect = 1e-20
Identities = 117/586 (19%), Positives = 258/586 (44%), Gaps = 74/586 (12%)
Query: 85 KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEK 144
+ Q++N+ +EN L E+K + + E +R ++E +Q Q+K
Sbjct: 1392 RAQIDNLTRENRSLSEEIK--------------RLKNTLTQTTENLRRVEEDIQ---QQK 1434
Query: 145 TQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENME 204
E+ Q R +L E Q+ ES + K L D + + ++N E
Sbjct: 1435 ATGSEVSQ-------RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT-----IQDKNKE 1482
Query: 205 VTN-QQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDV 263
+ +Q + T +E +L++ + +L+ A + E N + + ++ + D
Sbjct: 1483 IERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDY 1542
Query: 264 VSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELE 323
D+ + + Q+S+K+L+++ +E N+L+ + + ++L+ + +
Sbjct: 1543 ERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR 1602
Query: 324 NERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEV 383
E ++ N Q LE+A++ K K+ E+D+ + ++ V D +R K+
Sbjct: 1603 RSLKEQAIKITNLTQQLEQASIVK-------KRSEDDLRQQRD-----VLDGHLREKQRT 1650
Query: 384 ANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDY 443
++ RL+ E+ AL+ + ++Q +++ + ++ +E R ++ +
Sbjct: 1651 QE-------ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703
Query: 444 RKL----EEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQN-V 498
+L E + + L+ E +L+L + ++D + I + +Q N
Sbjct: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
Query: 499 LESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERG 558
LE + GL+++ LQ+E + LR+E E +K ALEA +++ S + ++ER
Sbjct: 1764 LELQ----GLIND----LQRERENLRQEIEKFQKQALEASN--RIQESKNQCTQVVQERE 1813
Query: 559 ---FEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSR 615
++++ E + + + + + + +A R K+ + + + +N K++ SR
Sbjct: 1814 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1873
Query: 616 QKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEER 661
+ +E + ++E EK +E EK L + + RLQ + + EER
Sbjct: 1874 K----EEAIRKIESEREK-SEREKNSL--RSEIERLQAEIKRIEER 1912
Score = 73.2 bits (178), Expect = 8e-13
Identities = 123/662 (18%), Positives = 251/662 (37%), Gaps = 79/662 (11%)
Query: 92 IKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQ---EKTQAV 148
+ E + LHSE+ +K E + I + + + L+ ++T
Sbjct: 927 LNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQ 986
Query: 149 ELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQ 208
+ QE +H Y E +T + + + L D + ++ V E + +
Sbjct: 987 SPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARD 1046
Query: 209 QFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHG 268
+ + + + L+K + + + +A +EEL E L G+ K+ D +G
Sbjct: 1047 ANSENCNKNKFLDQNLQKYQAECS-QFKAKLASLEELKRQAE-LDGKSAKQNLD--KCYG 1102
Query: 269 REEASDRRLQQLQSSI-------KQLEIRLCVT------IQEANQLRTENTHLEKQTREL 315
+ + + ++ +L I K +E R +Q+A Q EN +K E
Sbjct: 1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK 1162
Query: 316 QAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE----------------E 359
K E E ER +++ + + E L K + E+ +
Sbjct: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK 1222
Query: 360 DIEKMKETVSRFVQDATIRTKKEVANTKKQC---NIQISRLTEELSALQMECAEKQGQIE 416
+I KE S+ +++ R +E + K + N I + TE+ + +++
Sbjct: 1223 EISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS 1282
Query: 417 RVIKEKKAVEEELEKIYRE-GRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
++++K+ +E EL+++ ++ N + LEE + + + L+ R
Sbjct: 1283 EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Query: 476 QLETDSSEEISRYQEMIQKLQNVLESE---------------RENCGLVSEQRLKLQQEN 520
+ E + S+ + Y E I L+N E+E E+ Q L +EN
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTREN 1402
Query: 521 KQLRKE-----------TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDS 569
+ L +E TE+LR++ + Q++ E S +++ EV+LR++
Sbjct: 1403 RSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ-----KATGSEVSQRKQQLEVELRQVTQM 1457
Query: 570 NRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM 629
V + L K +E ++L + + N+ K L + Q + L+
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC-LEDENARLQRVQYDLQK 1516
Query: 630 ANEKVAENEKLILEHQEKANRLQ---RRLSQ----AEERAASASQQLSVITVQRRKAASL 682
AN E + +++ RL+ R+SQ ++ L + +Q++K
Sbjct: 1517 ANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEE 1576
Query: 683 MN 684
+N
Sbjct: 1577 LN 1578
Score = 62.0 bits (149), Expect = 2e-09
Identities = 121/598 (20%), Positives = 242/598 (40%), Gaps = 68/598 (11%)
Query: 86 LQLENVIKENE-RLHSELKDAVE-KKLEAFPLGTE-VGTDIYADDETVRNLQEQLQLANQ 142
LQ E+++K E RL E ++ K+EA+ G + + D+ + ++ +LQ A Q
Sbjct: 778 LQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQ 837
Query: 143 EKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKD-QLFDFQQLTKQLHVTNE 201
+Q + + +L + + E +T+ KQ D +L+D ++ KQL +
Sbjct: 838 IHSQTSQQYPLYDLDLGK----FGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
Query: 202 NMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEK 261
N Q F K + + K RQ LE K + V L Q K
Sbjct: 894 NY----QAFCKWLYDA---------KRRQDSLESM----KFGDSNTVMRFLNEQ-KNLHS 935
Query: 262 DVVSAHGREEASDRRLQQLQSSIKQLEIRLCVT---IQEANQLRTENTHLEKQTRELQAK 318
++ + E + + +SIK E++L ++ + + T ++ + + +
Sbjct: 936 EISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQE 995
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR 378
++ E + R+ + + L E ++L + K K IE ++E + R +DA
Sbjct: 996 AADVHARYIELLTRSGDYYRFLSEM----LKSLEDLKLKNTKIEVLEEEL-RLARDAN-- 1048
Query: 379 TKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRG 438
E N K + + + E S + + A + + + K+ ++ L+K Y + +
Sbjct: 1049 --SENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106
Query: 439 N-----------ESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISR 487
E + R+ + + RF + D LQ + + + +S + I
Sbjct: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE 1166
Query: 488 YQEMIQKLQNVLESE----RENCGLVSEQRLKLQQENKQLRKETE--------SLRKIAL 535
+ I++L+ +L+ E RE +++ R +E LR + E ++++I++
Sbjct: 1167 KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISM 1226
Query: 536 EAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHL--LATQQKAANRWKE 593
+ + +K + S + R + ++ + DS + + R A QQKA
Sbjct: 1227 QKEDDSK-NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG---S 1282
Query: 594 ETKKLTESAEIRINNLKSELSRQKL-HTQELLSQLEMANEKVAENEKLILEHQEKANR 650
E + + EI + + + S H Q L + +K E E+L E QE+A R
Sbjct: 1283 EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR 1340
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 111 bits (277), Expect = 3e-24
Identities = 146/688 (21%), Positives = 308/688 (44%), Gaps = 75/688 (10%)
Query: 8 LREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHL 67
L+ + R E + +S S+Y + + Q E E L + ++TE + L
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALEELELQKK---AILTESENKL 555
Query: 68 GELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADD 127
+L + + Y+ ++ E++ LE ++EN+ +L AV + E E+ +
Sbjct: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEAEKNKHNKEITVMVEKHK 613
Query: 128 ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLF 187
+ +L+ Q LW ++L L Q++ TE + + +++K+ L
Sbjct: 614 TELESLKHQQDA----------LWT------EKLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 188 DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTN 247
+++ Q H+ E N++ L+ + + +E L +L E+ A K+EE +
Sbjct: 658 KDKEIIFQAHI-----EEMNEKTLEKLDVKQTELESLSSELS----EVLKARHKLEEELS 708
Query: 248 VTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQ----EANQLRT 303
V +D +MK++ + + +E + QQ+ S IK+ E+ + T + + NQL
Sbjct: 709 VLKDQTDKMKQELEAKM-----DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Query: 304 ENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEK 363
+K +E QA LE + + + + L+ +S + K EE + +
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 364 MKETVSRFVQDATIRTKK--EVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKE 421
+++ + + + TK+ EV KK + EL A +++ + Q+E K+
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKD-------VCTELDAHKIQVQDLMQQLE---KQ 873
Query: 422 KKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDS 481
+E++++ + + D K +E ++ LV E+ LQ+R E + K++E
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV-EKENMILQMR----EGQKKEIEI-L 927
Query: 482 SEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKA 541
++++S ++ I L E++ +N Q K+++ ++ ++ E+L+K L+ + K
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKN------QEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
Query: 542 KVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTES 601
K ++ E S KE+ F ++ EM +N I + L T Q KE+ + LTE
Sbjct: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
Query: 602 AEIRINNL----KSELSRQKLHTQELLS-QLEMANEKVAENEKLILEHQEKANRLQRRLS 656
+N++ + +L++Q QE+ QL+ ++VAE ++ IL + + + ++
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT 1095
Query: 657 QAEERAASASQQLSVITVQRRKAASLMN 684
+E L+ + Q ++ ++ +N
Sbjct: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVN 1123
Score = 104 bits (260), Expect = 2e-22
Identities = 151/681 (22%), Positives = 283/681 (41%), Gaps = 93/681 (13%)
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY 124
+ L + L Y+ + E+ + + +E ++L L + +K L E+ ++
Sbjct: 141 QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI---AELREELQ 197
Query: 125 ADDETVRNLQEQLQLANQEKTQAVELWQT-VSQELDRLHK-------LYQEHMTEAQIHV 176
D + ++LQE+ + +EK Q + + QT VS RL L E Q V
Sbjct: 198 MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEV 257
Query: 177 FESQKQKDQ--------------LFDFQQLTKQ----LHVTNENMEVTNQQFLKTVTEQS 218
F ++ + L QQ K+ L E ++ +Q +E+
Sbjct: 258 FTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 219 VIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQ 278
+ EQL ++L++ + + +A+ +L D + +++ E+D G A +R
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQD----KGMVIAETKR-- 371
Query: 279 QLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQ 338
Q+ +++ E +E QLR+ + Q EL+ + + E +E + +A ++ Q
Sbjct: 372 QMHETLEMKE-------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ 424
Query: 339 LLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANT-KKQCNIQISRL 397
EEA +K +A ++E+ K IEK E +Q R K+EV + KK QI++L
Sbjct: 425 KTEEAR-RKLKAEMDEQIK--TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 398 ----TEELSALQMECAEKQGQIERVIKEKKAV-----EEELEKIYREGRGNESDYRKLEE 448
+EL+ + E +K ER +E+ V + E KI +E ES + E
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541
Query: 449 MHQRFLV--SERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESE---- 502
+ ++ ++ SE DLQ RI +LE+ + + + + L LE+E
Sbjct: 542 LQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601
Query: 503 -RENCGLVSEQRLKLQQ-ENKQLRKETESLRKIALEAQKKAKVKISTMEHE----FSIKE 556
+E +V + + +L+ +++Q TE L+ + + Q + + E E KE
Sbjct: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661
Query: 557 RGFEVQLREME-------DSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNL 609
F+ + EM D + + L L+ KA ++ +EE L + + L
Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721
Query: 610 KSELSRQKLHTQE-------------------LLSQLEMANEKVAENEKLILEHQEKANR 650
++++ QK H Q+ L Q+ + E +K + EHQ
Sbjct: 722 EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN 781
Query: 651 LQRRLSQAEERAASASQQLSV 671
L+ + ++E AS +L V
Sbjct: 782 LEADIKRSEGELQQASAKLDV 802
Score = 102 bits (255), Expect = 9e-22
Identities = 150/695 (21%), Positives = 275/695 (39%), Gaps = 80/695 (11%)
Query: 47 ENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLEN---------------- 90
E L DQ L E+D L E + + Q QV +K +L N
Sbjct: 194 EELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEP 253
Query: 91 ---VIKENERLHSELKDAVE-----KKLEAFPLGTEVGTDIYAD-DETVRNLQEQLQLAN 141
V + E S+ + VE K LE + ++ ET+++ +EQ L
Sbjct: 254 QAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT 313
Query: 142 QEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFES-----QKQKDQLFDFQQLTKQL 196
EK E QEL+++ L+ T+ + ++ Q ++D+ + +Q+
Sbjct: 314 SEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQM 373
Query: 197 HVTNENMEVTNQQFLKTVTEQSVIIEQLR----KKLRQAKLELRVAVAKVEELTNVTEDL 252
H T E E Q + + + E+LR K R A EL A++ ++ L
Sbjct: 374 HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTH---LE 309
+ +M ++ K + E S LQQ S +KQ + + E + + H L
Sbjct: 434 KAEMDEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA 490
Query: 310 KQTRELQAKCNELENERYEAIVRARNSMQ----------------LLEEANLQKSQALLE 353
++ +EL K E E E + A Q LEE LQK L E
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550
Query: 354 EKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQG 413
+ K D+++ ET + + +K + K Q L E K
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE--------KNKHN 602
Query: 414 QIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENR 473
+ V+ EK E E K ++ E + L++ +Q + R K + Q + T +++
Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEK-LQVLKQQYQTEMEKLREKCE-QEKETLLKDK 660
Query: 474 IKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKI 533
+ E + E + Q LES V + R KL++E L+ +T+ +++
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ- 719
Query: 534 ALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKE 593
LEA+ + + + IKE EV ++ E + ++ I +L LL KE
Sbjct: 720 ELEAKMDEQKNHHQQQVDSIIKEH--EVSIQRTEKALKDQINQLELLL----------KE 767
Query: 594 ETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQR 653
K L E + + NL++++ R + Q+ ++L++ + + ++E+ +LQ+
Sbjct: 768 RDKHLKEH-QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 654 RLSQAEERAASASQQLSVITVQRRKAASLMNLENI 688
+L E ++Q++ + Q++ + ++ I
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Score = 92.0 bits (227), Expect = 2e-18
Identities = 167/779 (21%), Positives = 320/779 (41%), Gaps = 159/779 (20%)
Query: 47 ENLVFDQSFLAPLVTE---YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELK 103
E L Q L L TE K + E+ Q K ++ K+Q+++++++ E+ +SE++
Sbjct: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Query: 104 DAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQ----LQLANQEKTQAVELWQTVSQELD 159
V+ + + E G ++T + L E+ LQ+ +K + L Q +S + D
Sbjct: 879 QKVKSLTQVYESKLEDGNK--EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 160 RLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQ------------LTKQLHVTNENMEVTN 207
+H L +E+ T+ + + +K K + + Q+ L K+L T +
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 208 QQF----LKTVTEQSVIIEQLRKKLRQAKLELRVAVAKV-------------EELTNVTE 250
+QF L+ S I +L + E ++ +V ++L E
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE 1056
Query: 251 DLQG----QMKKKEKDVVSAHGR-------------------EEA--SDRRLQQLQSSIK 285
+LQ Q+++KE++V + EE D L +LQ +K
Sbjct: 1057 ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
Query: 286 QLEIRLCVTIQEANQLRT--------------ENTHLEKQTREL-------QAKCNEL-- 322
Q + Q+ +L+ ENT L++Q EL + K +EL
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
Query: 323 ----ENERYEAIVRA-RNSMQLLEEANLQ-----------------KSQALLEEKQKE-- 358
+E ++++ + S + LE+ +L+ K++ALLE K E
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
Query: 359 -EDIEKMKETVSRFVQDATIRTKKEVANTKKQCNI-----QISRLTEELSALQM------ 406
K +SR TK + A K C + Q+ +LTEE + L +
Sbjct: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
Query: 407 -ECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQL 465
+ EK+ QI+ + + +++ E E + +EG GN+ +E L E S++ +
Sbjct: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEG-GNQQQAASEKESCITQLKKELSENINAV 1355
Query: 466 RLTRAENRIKQLETDS-SEEISRYQEMIQKLQNVLESERENCGL---VSEQRLKLQQENK 521
L + E + K++E S S++++ +Q ++ E E L E++ +L + +
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
Query: 522 QLRKETESLRKIALEA------------QKKAKVKISTMEHEFSIKERGFEVQLREMEDS 569
L + ++L K + A + K K + +H+ ++KE +++L+ E
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
Query: 570 NRNSIVE-LRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQEL----- 623
++ + L+ L Q K + K E + E + +NL++EL Q EL
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 624 --LSQLEMANEKVAE-NEKLILEHQEKANRLQ----------RRLSQAEERAASASQQL 669
++E NE + N++ +EH+E +LQ R+ +AEE+ + Q+
Sbjct: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Score = 88.6 bits (218), Expect = 2e-17
Identities = 130/639 (20%), Positives = 272/639 (42%), Gaps = 77/639 (12%)
Query: 69 ELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDE 128
EL+ Q K + GEM+ + K+ L +ELK + +E T+ +I + +E
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 129 TVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFD 188
++N +Q + ++E Q ++ +Q + +E D K +E + + V+ + + +
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE---- 1602
Query: 189 FQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLR-QAKLELRVAVAKVEELTN 247
TK+ + + N+ V +++ E + E K + K E ++A K + L+
Sbjct: 1603 ----TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Query: 248 VTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTH 307
+ E + K E + + + + +R + L+ +K +E T+ + +
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 308 LEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEE--KQKEEDIEKMK 365
E++ + Q + E+ + R NL + + LL+ ++KEE +
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQR-----------NLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 366 ETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL-------SALQMECAEKQG----- 413
E ++ Q+ I+ + A + ++ I L EEL S + + EK+G
Sbjct: 1768 EMRCQY-QERLIKLEHAEAKQHEDQSM-IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
Query: 414 -----------QIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDD 462
+++ ++EK+ + LE+ +E +S + +E+H+ + SK +
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKE---LDSCLVRQKEVHRVEMEELTSKYE 1882
Query: 463 LQLRLTRAENRIK--QLETDSSEEISRYQEMIQKLQNVLESERENCGL----VSEQRLKL 516
L + + R K +L +++EE S+ + KL + +E++ + ++ KL
Sbjct: 1883 KLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL 1942
Query: 517 QQENKQLRKETESLRKIALEAQKKAKV--KISTMEHEFSIKERGFEVQLRE-------ME 567
+E +L+K+ LRK E Q++ ++ K E E IK+ +++L+ M
Sbjct: 1943 GKEIVRLQKDLRMLRK---EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMR 1999
Query: 568 DSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNL-------KSELSRQKLHT 620
+ N + + L T ++ N+ +E +L ES + N L +L R
Sbjct: 2000 EFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY 2059
Query: 621 QELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAE 659
+E+L E E A+ L + +E + Q++L Q E
Sbjct: 2060 EEILDARE--EEMTAKVRDLQTQLEELQKKYQQKLEQEE 2096
Score = 86.3 bits (212), Expect = 9e-17
Identities = 132/654 (20%), Positives = 275/654 (42%), Gaps = 78/654 (11%)
Query: 64 DKHLGELNGQLKYYQKQVG--------------EMKLQLENVIKENERLHSELKDAVEKK 109
D L EL QLK V ++++ L +KEN L +L +
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 110 LEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELD-------RLH 162
E +E+ + + DE ++L+ + +N+ ++ +S+EL +
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 163 KLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIE 222
+ E T I++ S+ L++ H + +V +KT T +
Sbjct: 1225 EALLEAKTNELINISSSKTNAI-------LSRISHCQHRTTKVKEALLIKTCT-----VS 1272
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQS 282
+L +LRQ E ++ T+ E+ + Q+K + D+ S +EA + Q
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
+ + E + +E ++ T ++++ +E + + + L + + V+ +NS+ L E+
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 343 ANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRT---KKEVANTKKQCNIQISRLTE 399
+A + +K+ D EK + + VQD + + KE + +Q + ++ +E
Sbjct: 1393 ------EAAISSLRKQYDEEKCE--LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 400 ELSALQMECAEKQG-----QIERVIKEKKAVE-EELEKIYREGRGNESDYRKLEEMHQRF 453
Q + Q QI+ +K K+A E +E + +E +L++ ++RF
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE---------ELDQQNKRF 1495
Query: 454 LVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKL-QNVLESERENCGLVSEQ 512
+ K +++ ++ E + LET+ + +R E+ + Q +E E N L +
Sbjct: 1496 ---DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN 1552
Query: 513 RLKLQQENKQLRKETESLRKIALEAQ---KKAKVKISTMEHEFSIKERGFEVQLREMEDS 569
+ K E+K+L ++ + +++ E K+A+ KI T+E++ + E + +E+E
Sbjct: 1553 QQK-DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHV 1611
Query: 570 NRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM 629
N + + L A + + + + +L AE +I +K ++LLSQ+E
Sbjct: 1612 NLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK----------KQLLSQMEE 1661
Query: 630 ANEKVAE-NEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASL 682
E+ + E + E K +R + EE+ S S + R A ++
Sbjct: 1662 KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Score = 76.3 bits (186), Expect = 9e-14
Identities = 100/506 (19%), Positives = 235/506 (46%), Gaps = 71/506 (14%)
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD- 122
+ HL ELN +L+ +++V ++ +L++V E+ + + + K + A+ E +
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSV--ESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 123 ----IYADDETV--RNLQEQ---LQLANQEKTQAVEL-WQTVSQELDRLHKLY----QEH 168
Y + +V RNL E+ LQ QEK + V ++ Q +RL KL ++H
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH 1788
Query: 169 MTEAQI-HVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKK 227
++ I H+ E ++K++ + L HV E + ++ + + ++K
Sbjct: 1789 EDQSMIGHLQEELEEKNKKYS---LIVAQHVEKEG----GKNNIQAKQNLENVFDDVQKT 1841
Query: 228 LRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQL 287
L++ +L ++ K++EL + + + + +++ S + + +A LQQ+ K
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA----LQQMDGRNKPT 1897
Query: 288 EIRLCVTIQEANQLRTEN--------THLEKQTRELQAKCNELENERYEA---IVRARNS 336
E+ ++E + ++++ +++E Q +L+ K E E+ + IVR +
Sbjct: 1898 EL-----LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 337 MQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISR 396
+++L + + Q+ + L +E +E + EK+K+ +D ++ + ++ N Q+++
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQERE-EKIKQEQ----EDLELKHNSTLKQLMREFNTQLAQ 2007
Query: 397 LTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVS 456
+EL E K ++E + E +EE ++ ++ + D ++ +
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESH--QEETNQLLKKIAEKDDDLKR---------TA 2056
Query: 457 ERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQN-------VLESE---RENC 506
+R ++ L R +++ L+T E +YQ+ +++ +N ++E + +
Sbjct: 2057 KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
Query: 507 GLVSEQRLKLQQENKQLRKETESLRK 532
L+S+ +LK Q+ +Q+ + L+K
Sbjct: 2117 TLISDSKLKEQEFREQIHNLEDRLKK 2142
Score = 70.9 bits (172), Expect = 4e-12
Identities = 105/499 (21%), Positives = 225/499 (45%), Gaps = 67/499 (13%)
Query: 222 EQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
EQL ++LR+ + L K EL + LQ + KKK + ++S ++ S RR+ +L+
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE-KKKLQGILSQS--QDKSLRRIAELR 193
Query: 282 SSI-------KQLEIRLCVTIQEANQ----LRTENTHLEKQTRELQAKCNELENERYEAI 330
+ K L+ +++E +Q L+T+ + L+++ R + L+
Sbjct: 194 EELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQ--- 250
Query: 331 VRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQC 390
+ + + EE + ++E+ + +E +++ V R ++ R K+ + + K+QC
Sbjct: 251 LEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKR-QENLLKRCKETIQSHKEQC 309
Query: 391 NIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMH 450
+ LT E ALQ + E+ ++E++ K E K+ + R ++ +LE+
Sbjct: 310 TL----LTSEKEALQEQLDERLQELEKI---KDLHMAEKTKLITQLRDAKNLIEQLEQ-D 361
Query: 451 QRFLVSERSK---DDLQLR---LTRAENRIKQLETDSSE--------EISRYQEMIQKLQ 496
+ +++E + + L+++ + + +RIKQ+ T E E + ++E+ + L
Sbjct: 362 KGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALS 421
Query: 497 NVLESERENCGLVSE--------------QRLKLQQENKQLRKETESLRKIALEAQ---- 538
++E L +E +R+ LQQE ++++E + K + E Q
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 539 -----KKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKE 593
K+ K + + +ER F+ Q++ + +++ +++ Q+ A E
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541
Query: 594 ETKK--LTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQE-KANR 650
KK LTES E ++ +L+ E + EL S LE + ++ K + H E + N+
Sbjct: 542 LQKKAILTES-ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 651 LQRRLSQAEERAASASQQL 669
+ ++ E+ + + L
Sbjct: 601 HNKEITVMVEKHKTELESL 619
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/371 (18%), Positives = 165/371 (44%), Gaps = 31/371 (8%)
Query: 308 LEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKET 367
++ + +L + L E + I R R + L + S+ + + + + +K++
Sbjct: 120 MDSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
Query: 368 VSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEE 427
+S+ QD ++R E+ + L EE A E++ Q V++ + ++
Sbjct: 178 LSQS-QDKSLRRIAELREELQMDQQAKKHLQEEFDA----SLEEKDQYISVLQTQVSL-- 230
Query: 428 ELEKIYREGRGNESDYRKLEEMHQR---FLVSERSKDDLQLRLTRAENRIKQLETDSSEE 484
L++ R G N + L ++ + F E + D + + +K LET +
Sbjct: 231 -LKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGE-PVVEDGTSVKTLET-LQQR 287
Query: 485 ISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK---- 540
+ R + ++++ + ++S +E C L++ ++ LQ++ + +E E ++ + + + K
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ 347
Query: 541 ---AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKK 597
AK I +E + + + Q+ E + I +LR + +E+ +K
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 598 LTESAEIRINNL-----KSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQ 652
+A + K+E +R+KL E+ Q++ EK +E E++ L Q++ +R++
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKA-EMDEQIKTI-EKTSEEERISL--QQELSRVK 463
Query: 653 RRLSQAEERAA 663
+ + ++++
Sbjct: 464 QEVVDVMKKSS 474
Score = 30.0 bits (66), Expect = 7.5
Identities = 43/204 (21%), Positives = 81/204 (39%), Gaps = 50/204 (24%)
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKEN----ERLHSELKDAVEKKL-EAFPLGTEV 119
KH L ++ + Q+ + + +LE IKE + + +EL ++ +++ + E
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
Query: 120 GTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFES 179
D+ T + +E L +E T V QT +L+ L K YQ
Sbjct: 2049 DDDL---KRTAKRYEEILDAREEEMTAKVRDLQT---QLEELQKKYQ------------- 2089
Query: 180 QKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAV 239
Q+L ++ + N+N V I +L+ +L Q + +
Sbjct: 2090 ----------QKLEQEENPGNDN----------------VTIMELQTQLAQKTTLISDSK 2123
Query: 240 AKVEELTNVTEDLQGQMKKKEKDV 263
K +E +L+ ++KK EK+V
Sbjct: 2124 LKEQEFREQIHNLEDRLKKYEKNV 2147
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 110 bits (276), Expect = 3e-24
Identities = 153/719 (21%), Positives = 309/719 (42%), Gaps = 82/719 (11%)
Query: 6 DFLREQNRRLNEDFRRYQMESFSKYSSVQ-KAVCQGEGDDTFENLVFDQSFLAPLVTEYD 64
++L+E + ++ +R F K +++ +A +G++ N + L ++
Sbjct: 561 NYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLT 620
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDI- 123
+ EL QL+ E+K Q +N+ +E ER+ + L++ + E + + +
Sbjct: 621 IEVAELQRQLQL------EVKNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
Query: 124 YADDETVRNLQEQLQL---ANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQ 180
++ E +NL+E Q+ Q +T+ +L +S+ D L + E + E
Sbjct: 674 ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 181 KQKDQLFDF---------------QQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR 225
+ K L D ++LT E + +Q+ K + ++ LR
Sbjct: 734 QAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793
Query: 226 KKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIK 285
+ + +A + V ++ + ++K +++ GR E +RR+ QLQ I+
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 286 QL---EIRLCVTIQ----EANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQ 338
L E + T++ E QL H K+ +E + LENE + A+ ++
Sbjct: 854 DLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE----LEAAQGNLS 909
Query: 339 LLEEANLQKSQALLEEKQKEEDIEKMKETV--SRFVQDATI-RTKKEVANTKKQCNIQIS 395
+ Q S+ L EE +++E + ++K + R+ TI + +KE+A+ +
Sbjct: 910 QTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL 969
Query: 396 RLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLV 455
L +L + + + +++R +KEK E EK + + R +EE + +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTL---EAEKSRLTAMKMQDEMRLMEEELRDY-- 1024
Query: 456 SERSKDDLQLRLTRAENRIKQLE----------TDSSEEISRYQEMIQKLQNVLESEREN 505
+R++D+ + E +K LE D S + + ++ + +L+ LE ER N
Sbjct: 1025 -QRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN 1083
Query: 506 CGLVSEQRLKLQQENKQLRKETESLR---------KIALEAQKK-AKVKISTMEHEFSIK 555
L+SE+ + +++ +QLR E R KI+LE Q K K +I +E +
Sbjct: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
Query: 556 ERGFEVQLR----EMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKS 611
+ G VQ+ E+ED + + +L + ++ + KE ++ + + + + K
Sbjct: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV-DDEHLSLTDQKD 1202
Query: 612 ELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS 670
+LS L + + Q+E A E++ LE +K +LQR L + + QL+
Sbjct: 1203 QLS---LRLKAMKRQVEEAEEEIDR-----LESSKK--KLQRELEEQMDMNEHLQGQLN 1251
Score = 91.3 bits (225), Expect = 3e-18
Identities = 142/584 (24%), Positives = 248/584 (42%), Gaps = 75/584 (12%)
Query: 128 ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKD-QL 186
E ++ L+ + + Q QA V L++ KL I V E Q+Q ++
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKL--------TIEVAELQRQLQLEV 634
Query: 187 FDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRK---KLRQAKLELRVAVAKVE 243
+ Q + ++ N+E Q + V E S + ++L + +LR+ EL + E
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 244 ELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRT 303
+ DLQ Q+ + ++ SA E+ L + KQ L + +E L
Sbjct: 695 QHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL-- 752
Query: 304 ENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE---ANLQKSQALLEEKQKEED 360
L K+ REL A L+ E + M L+E A LQ + +EE K +
Sbjct: 753 ----LRKRERELTALKGALKEE----VSSHDQEMDKLKEQYDAELQALRESVEEATKNVE 804
Query: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK 420
+ + S +++ A T+ + + + E+L E + Q++R I+
Sbjct: 805 VLASRSNTS----------EQDQAGTEMRVKL-LQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 421 EKKAVEEELEKIYREGRGNESDYRKLEEM------HQRFLVSERSKDDLQLR-----LTR 469
+ K E + ++ ++ G + R+LEE ++ VS R + +L L++
Sbjct: 854 DLKGDEAKAKETLKKYEG---EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910
Query: 470 AENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
KQL EE S +E +++L+N +E+ER + G E KLQ+E + E+
Sbjct: 911 TTQEQKQLSEKLKEE-SEQKEQLRRLKNEMENERWHLGKTIE---KLQKEMADI---VEA 963
Query: 530 LRKIALEAQK-----KAKVKISTMEHEFSIKERGFEVQ-----LREMEDSNRNSIVELRH 579
R LE Q K K + E + +KE+ E + +M+D R ELR
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRD 1023
Query: 580 LLATQQKAANRWK--EETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAEN 637
Q +A + + E+T K E ++LK + SR ++ +SQLEM E+ N
Sbjct: 1024 YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN 1083
Query: 638 EKLILEH----QEKANRLQRRLSQAEERAASASQQLSVITVQRR 677
L+ E +E+ +L+ L Q ERAA + I+++R+
Sbjct: 1084 SDLLSERISRSREQMEQLRNELLQ--ERAARQDLECDKISLERQ 1125
Score = 66.6 bits (161), Expect = 7e-11
Identities = 89/425 (20%), Positives = 169/425 (39%), Gaps = 40/425 (9%)
Query: 263 VVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNEL 322
V+ G +E++ R L + K+ E T Q R T + +++ K
Sbjct: 470 VLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPS 529
Query: 323 ENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE-----EDIEKMK-ETVSRFVQDAT 376
+ + +L ++ N + ++ +L KE +D K K V +Q
Sbjct: 530 ASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLK 589
Query: 377 IRTKKEVANTKKQCNI--QISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYR 434
R + CN ++ L E+ S L +E AE Q Q++ +K ++ ++EE E++
Sbjct: 590 SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-- 647
Query: 435 EGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQK 494
R N LEE+ + LQ RL +E +++ + EE+ +Q +++
Sbjct: 648 --RAN------LEELRSQHNEKVEENSTLQQRLEESEGELRK----NLEEL--FQVKMER 693
Query: 495 LQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSI 554
Q+ E R+ +SE +L + +E +L + L+A++ + + E
Sbjct: 694 EQHQTEI-RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE----- 747
Query: 555 KERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELS 614
E ED R EL L ++ + +E KL E + + L+ +
Sbjct: 748 ----------EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 615 RQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITV 674
+ + L S+ + + A E + QE+ +LQ R + E R A +Q+ +
Sbjct: 798 EATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKG 857
Query: 675 QRRKA 679
KA
Sbjct: 858 DEAKA 862
Score = 32.3 bits (72), Expect = 1.5
Identities = 53/267 (19%), Positives = 120/267 (44%), Gaps = 30/267 (11%)
Query: 8 LREQNRRLNEDFRRYQM---ESFSKYSSVQKAVCQGEGD-DTFENLVFDQSFLAPLVTEY 63
++++ R + E+ R YQ E+ +K +++ + E + + +L D+S LV +
Sbjct: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS---RLVKQM 1066
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSEL--KDAVEKKLEAFPLGTE--- 118
+ + +L +L+ + + ++ ++ E+L +EL + A + LE + E
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
Query: 119 --VGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHV 176
+ + I + + R+ +E L + + + +E + S+E DR + E ++
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERDRANLQLSNRRLERKVKE 1185
Query: 177 FESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELR 236
Q + L LT Q + ++ +Q ++ E+ +E +KKL++
Sbjct: 1186 LVMQVDDEHL----SLTDQKDQLSLRLKAMKRQ-VEEAEEEIDRLESSKKKLQR------ 1234
Query: 237 VAVAKVEELTNVTEDLQGQMKKKEKDV 263
++EE ++ E LQGQ+ +KD+
Sbjct: 1235 ----ELEEQMDMNEHLQGQLNSMKKDL 1257
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 109 bits (273), Expect = 7e-24
Identities = 160/734 (21%), Positives = 305/734 (41%), Gaps = 117/734 (15%)
Query: 8 LREQNRRLNEDFRRYQMESFSKYSSV-----QKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
L + R L + ++ ++ SV Q+A Q E + L ++ ++ L
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT-- 1302
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
G+L Y Q Q+ ++K QLE +K K+A+ L++ ++ +
Sbjct: 1303 --------RGKLTYTQ-QLEDLKRQLEEEVKA--------KNALAHALQSARHDCDLLRE 1345
Query: 123 IYADD-ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
Y ++ E LQ L AN E Q W+T E D + + E + EA+ +K
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQ----WRT-KYETDAIQRT--EELEEAK------KK 1392
Query: 182 QKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQ-------LRKKLRQAKLE 234
+L + ++ + ++ ++E T + + + V +E+ L KK R
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 235 LRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVT 294
L K EE + E Q + + ++ E S L+ + K L+ +
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Query: 295 IQEANQLRTENTHLEKQTRELQAKCNELEN--ERYEAIVRARNSMQLLEEANLQKSQALL 352
++ LEK ++L+A+ EL++ E EA + L + + +A +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572
Query: 353 EEK--QKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRLTEELSAL 404
E K +K+E++E+ K R V DA R++ E KK+ ++ + +LS
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 405 QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQ 464
AE Q Q++ + K + +L+ R +++ + + ER + LQ
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN----------DDLKENIAIVERRNNLLQ 1682
Query: 465 LRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLR 524
L ++Q T+ S +++ QE+I+ + V +N L+++++ K+ + QL+
Sbjct: 1683 AELEELRAVVEQ--TERSRKLAE-QELIETSERVQLLHSQNTSLINQKK-KMDADLSQLQ 1738
Query: 525 KETESLRKIALEAQKKAKVKIS--TMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLL- 581
E E + A++KAK I+ M E KE+ L M+ + +I +L+H L
Sbjct: 1739 TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798
Query: 582 ATQQKAANRWKEETKKLTESAEIRINNLKSELSRQK------------------------ 617
+Q A K++ +KL E R+ L++EL ++
Sbjct: 1799 EAEQIALKGGKKQLQKL----EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQT 1854
Query: 618 -------LHTQELLSQLEMANEKVAENEKLILEHQEKAN-------RLQRRLSQAEERAA 663
L Q+L+ +L++ KV ++ E +E+AN ++Q L +AEERA
Sbjct: 1855 EEDRKNLLRLQDLVDKLQL---KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911
Query: 664 SASQQLSVITVQRR 677
A Q++ + + R
Sbjct: 1912 IAESQVNKLRAKSR 1925
Score = 96.3 bits (238), Expect = 8e-20
Identities = 133/630 (21%), Positives = 261/630 (41%), Gaps = 95/630 (15%)
Query: 80 QVGEMKLQLENVIKE-NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQ 138
Q+ + K+QLE +KE NERL E + E + L E +++ D + +L+ L
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC-SELKRD---IDDLELTLA 962
Query: 139 LANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHV 198
+EK + +++E+ L ++ + E + Q+ D L + L
Sbjct: 963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
Query: 199 TNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKK 258
+E ++ ++ + L + R+ + +L++ + +L N + L ++KK
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Query: 259 KEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAK 318
K+ ++ + + R E QLQ +K+L+ R+ +E RT +EK +L +
Sbjct: 1083 KDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR 378
E+ + LEEA S + K++E + +KM+ R +++AT++
Sbjct: 1143 LEEIS--------------ERLEEAGGATSVQIEMNKKREAEFQKMR----RDLEEATLQ 1184
Query: 379 TKKEVANTKKQCNIQISRLTEELSALQ--------------MECAEKQGQIERVIKEKKA 424
+ A +K+ ++ L E++ LQ +E + +E++IK K
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK-- 1242
Query: 425 VEEELEKIYREGRGNESDYRKLEEMHQRF---LVSERSK-----DDLQLRLTRAENRIKQ 476
LEK+ R +++R E QR L S+R+K +L +L E I Q
Sbjct: 1243 --ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1300
Query: 477 LE------TDSSEEISRYQEMIQKLQN----VLESERENCGLVSEQRLKLQQENKQLRKE 526
L T E++ R E K +N L+S R +C L+ EQ +E + + E
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ----YEEETEAKAE 1356
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQK 586
+ + A + + K T ++I L ++K
Sbjct: 1357 LQRVLSKANSEVAQWRTKYET------------------------DAIQRTEELEEAKKK 1392
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMAN-------EKVAENEK 639
A R +E ++ E+ + ++L+ R + ++L+ +E +N +K +K
Sbjct: 1393 LAQR-LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Query: 640 LILEHQEKANRLQRRLSQAEERAASASQQL 669
++ E ++K Q L +++ A S S +L
Sbjct: 1452 ILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Score = 92.8 bits (229), Expect = 9e-19
Identities = 124/638 (19%), Positives = 275/638 (43%), Gaps = 70/638 (10%)
Query: 4 EIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGD--DTFENLVFDQSFLAPLVT 61
+ D LREQ E Q S V + + E D E L + LA +
Sbjct: 1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E ++ + +N + +K ++ ++E+++ + ER ++ A++KK F
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA-ALDKKQRNF-------- 1449
Query: 122 DIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
D+ + +++ + + E + + +++S EL +L Y+E + + E++
Sbjct: 1450 -----DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504
Query: 182 QKDQLFDFQQ-------LTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLE 234
++++ D + +L + +E + + E +E K+ +A+LE
Sbjct: 1505 LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Query: 235 LRVAVAKVEELTNVTEDLQGQMKKKEKDVVSA---------HGREEASDRRLQQLQSSIK 285
A++E ++ Q K+ VV + R EA R ++++ +
Sbjct: 1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL-RVKKKMEGDLN 1623
Query: 286 QLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYE-----AIVRARNSMQLL 340
++EI+L + A + + + L+ ++ Q + ++ + AIV RN+ L
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN---L 1680
Query: 341 EEANLQKSQALLEEKQKEEDI--EKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLT 398
+A L++ +A++E+ ++ + +++ ET R + T + N KK+ + +S+L
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS--LINQKKKMDADLSQLQ 1738
Query: 399 EELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSER 458
E+ EC + + ++ I + + EEL+K + LE M + E+
Sbjct: 1739 TEVEEAVQECRNAEEKAKKAITDAAMMAEELKK-------EQDTSAHLERMKKNM---EQ 1788
Query: 459 SKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQ 518
+ DLQ RL AE + +++ + + +++L+N LE+E++ + K ++
Sbjct: 1789 TIKDLQHRLDEAEQIALK---GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 519 ENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMED---SNRNSIV 575
K+L +TE RK L ++ + + +K + ++ Q E E+ +N +
Sbjct: 1846 RIKELTYQTEEDRKNLL--------RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1897
Query: 576 ELRHLLATQQKAANRWKEETKKL-TESAEIRINNLKSE 612
+++H L ++ A+ + + KL +S +I L E
Sbjct: 1898 KVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 91.3 bits (225), Expect = 3e-18
Identities = 141/695 (20%), Positives = 295/695 (42%), Gaps = 87/695 (12%)
Query: 69 ELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYA 125
+L G LK Q+ + ++ K QL+ +K+ + + L +E + LG+++ +
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE---DEQALGSQLQKKLKE 1110
Query: 126 DDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQ 185
+ L+E+L+ + + +L +S+EL+ + + +E + + E K+++
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI-EMNKKREA 1169
Query: 186 LF-----DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLR----QAKLELR 236
F D ++ T Q T + + + + EQ ++++++KL + KLEL
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 237 VAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSS-----------IK 285
+ +E++ +L+ + E + + E + R + L S +
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Query: 286 QLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANL 345
QL+ + + Q T LE R+L+ + + +N A+ AR+ LL E
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV-KAKNALAHALQSARHDCDLLREQYE 1348
Query: 346 QKSQALLE-EKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSAL 404
++++A E ++ + ++ + +++ DA RT +E+ KK+ ++ E + A+
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 405 QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRK----LEEMHQRFLVSERSK 460
+C+ + R+ E + + ++E+ + R L E Q++ E S+
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY---EESQ 1464
Query: 461 DDLQLRLTRAEN------RIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRL 514
+L+ A + ++K +S E + ++ + LQ + E G +
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH 1524
Query: 515 KLQQENKQLRKETESLRKIALEAQ---KKAKVKISTMEHEFS-IK---ERGFEVQLREME 567
+L++ KQL E L+ EA+ + + KI + EF+ IK ER + EME
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 568 DSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELS----------RQK 617
+ RN + + L T A R + E ++ + E +N ++ +LS +Q
Sbjct: 1585 QAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1643
Query: 618 LHTQELLSQLEM-------ANEKVAEN---------------EKL--ILEHQEKANRL-Q 652
Q LL ++ AN+ + EN E+L ++E E++ +L +
Sbjct: 1644 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Query: 653 RRLSQAEERAASA-SQQLSVITVQRRKAASLMNLE 686
+ L + ER SQ S+I +++ A L L+
Sbjct: 1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ 1738
Score = 76.3 bits (186), Expect = 9e-14
Identities = 98/472 (20%), Positives = 201/472 (42%), Gaps = 61/472 (12%)
Query: 258 KKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQA 317
++EK++ S L++ ++ K+LE ++ +QE N L+ + + + +
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 318 KCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATI 377
+C++L + + + + + LE+ ++ ++++ E++ ++K + D
Sbjct: 904 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI-----DDLE 958
Query: 378 RTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGR 437
T +V K ++ LTEE++ L I ++ KEKKA++E ++ + +
Sbjct: 959 LTLAKVEKEKHATENKVKNLTEEMAGL-------DEIIAKLTKEKKALQEAHQQALDDLQ 1011
Query: 438 GNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSE---EISRYQEMIQK 494
E K+ + + + E+ DDL+ L + + LE + ++ QE I
Sbjct: 1012 AEED---KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068
Query: 495 LQNVLESERE------------NCGLVSEQRL--KLQQENKQLRKETESLRKIALEAQKK 540
L+N + E N + EQ L +LQ++ K+L+ E L + LEA++
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE-ELEAERT 1127
Query: 541 AKVKISTMEHEFS---------IKERGFEVQLR-EMEDSNRNSIVELRHLL--ATQQKAA 588
A+ K+ + + S ++E G ++ EM ++R L AT Q A
Sbjct: 1128 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1187
Query: 589 NRWKEETKKLTESAEI--RINN-------LKSELSRQKLHTQELLSQLEMANEKVAENEK 639
K AE+ +I+N L+ E S KL ++ S +E + A EK
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247
Query: 640 L-------ILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMN 684
+ + EH+ KA QR ++ + A + ++ Q + +L++
Sbjct: 1248 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Score = 75.1 bits (183), Expect = 2e-13
Identities = 83/455 (18%), Positives = 199/455 (43%), Gaps = 29/455 (6%)
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQS 282
+L++ L +++ + K+ L DLQ Q++ ++ ++ A R + + QL++
Sbjct: 858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 917
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
+K++ RL ++ ++ N L + R+L+ +C+EL+ + + L
Sbjct: 918 KVKEMNERL----EDEEEM---NAELTAKKRKLEDECSELKRDIDDL---------ELTL 961
Query: 343 ANLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRLT 398
A ++K + E K K E++ + E +++ ++ A ++ + + +++ LT
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 399 EELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSER 458
+ L+ + + +G +E+ K + +E K+ + + + LE Q+ L
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ-LDERL 1080
Query: 459 SKDDLQLRLTRAENRIKQ-LETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQ 517
K D +L A +Q L + +++ Q I++L+ LE+ER V + R L
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLS 1140
Query: 518 QENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSI 574
+E +++ + E + +E KK + + M + E + + +S+
Sbjct: 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200
Query: 575 VELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV 634
EL + Q+ + ++E + + +N++ ++ + K + +++ LE +++
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME-QIIKAKANLEKMCRTLE---DQM 1256
Query: 635 AENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669
E+ E Q N L + ++ + S+QL
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL 1291
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 107 bits (268), Expect = 3e-23
Identities = 160/771 (20%), Positives = 323/771 (41%), Gaps = 124/771 (16%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEG--DDTFENLVFDQSFLAP 58
+ +ID L+ ++L ++ +ME+ SS +A+ + +G + +L S L
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMET-DDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 59 LVTEYDKHLGELNGQLKYYQKQVGEMKLQLENV--------------------IKENERL 98
E + + +L Q Q + GE QL+ +K
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324
Query: 99 HSELKDAVEKKLEAFPLGTEVGTDIYADDETVR-NLQEQLQLANQEKTQAVELWQTVS-- 155
++ K+A+ L++ ++ + Y +++ + LQ L AN E Q ++T +
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1384
Query: 156 --QELDRLHKLYQEHMTEAQIHV---------FESQKQK--DQLFDFQQLTKQLHVTNEN 202
+EL+ K + + EA+ HV E KQ+ +++ D ++ +
Sbjct: 1385 RTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAA 1444
Query: 203 MEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKD 262
++ + F K ++E E+ + +L ++ E R ++ ++ NV E+ Q+
Sbjct: 1445 LDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL------ 1498
Query: 263 VVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNEL 322
E R + LQ I L ++ ++ ++L +E++ E+QA E
Sbjct: 1499 --------ETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA 1550
Query: 323 EN--ERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQ------D 374
E E E + +++ E N KS+ + +K+E+I+++K +R V+ D
Sbjct: 1551 EASLEHEEGKI-----LRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Query: 375 ATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYR 434
A IR++ + KK+ ++ + +L+ R+ E + I +
Sbjct: 1606 AEIRSRNDALRVKKKMEGDLNEMEIQLN-----------HANRLAAESLRNYRNTQGILK 1654
Query: 435 EGRGNESD-YRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQ 493
E + + D R E++ ++ + ER + LQ + ++Q T+ S +I+ QE++
Sbjct: 1655 ETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQ--TERSRKIAE-QELLD 1711
Query: 494 KLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKIS--TMEHE 551
+ V +N L++ ++ KL+ + QL+ E E + + + A++KAK I+ M E
Sbjct: 1712 ASERVQLLHTQNTSLINTKK-KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAE 1770
Query: 552 FSIKERGFEVQLREMEDSNRNSIVELRHLL-ATQQKAANRWKEETKKLTESAEIRINNLK 610
KE+ L M+ + ++ +L+H L +Q A K++ +KL E R+ L+
Sbjct: 1771 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL----EARVRELE 1826
Query: 611 SELSRQKLHTQELLSQLEMANEKVAE-------NEKLIL--------------------- 642
E+ ++ E + L +V E + K +L
Sbjct: 1827 GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886
Query: 643 --EHQEKAN-----RLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLE 686
E Q AN +LQ L +AEERA A Q++ + V+ R+ + ++ E
Sbjct: 1887 EAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 91.3 bits (225), Expect = 3e-18
Identities = 144/678 (21%), Positives = 271/678 (39%), Gaps = 106/678 (15%)
Query: 65 KHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY 124
K +L Q++ + + + + E +IK +L +++K+ E+ E + E+
Sbjct: 885 KEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKR 944
Query: 125 ADDETVRNLQE-----QLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFES 179
++ L++ +L LA EK + + K E M + +
Sbjct: 945 KLEDECSELKKDIDDLELTLAKVEKEK---------HATENKVKNLTEEMAGLDETIAKL 995
Query: 180 QKQKDQLFD-FQQLTKQLHVTNENMEVTNQQFLKTVTEQSV-----IIEQ---LRKKLRQ 230
K+K L + QQ L + + + + KT EQ V +EQ LR L +
Sbjct: 996 SKEKKALQETHQQTLDDLQAEEDKVNILTKA--KTKLEQQVDDLEGSLEQEKKLRMDLER 1053
Query: 231 AKL----ELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQ 286
AK +L++A ++ N + L +++KKE ++ + + E QLQ IK+
Sbjct: 1054 AKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKE 1113
Query: 287 LEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEA--IVRARNSMQLLEEAN 344
L+ R+ +E R EKQ +L + E+ EA A+ + EA
Sbjct: 1114 LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE 1173
Query: 345 LQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSAL 404
QK + LEE + E M + + D+ +++ N ++ +L +E S L
Sbjct: 1174 FQKLRRDLEEATLQH--EAMVAALRKKHADSMAELGEQIDNLQR----VKQKLEKEKSEL 1227
Query: 405 QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQ 464
+ME + E + K K LEK+ R S+ + EE QR L+++ + +
Sbjct: 1228 KMETDDLSSNAEAISKAK----GNLEKMCRSLEDQVSELKTKEEEQQR-LINDLTAQRAR 1282
Query: 465 LRLTRAE---------------NRIKQLETDSSEEISRYQEMIQKLQN----VLESEREN 505
L+ E +R KQ T EE+ E K +N L+S R +
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 506 CGLVSEQRLKLQQENKQLRK----------------ETESLRKIALEAQKKAKVKISTME 549
C L+ EQ + Q+ +L++ ET+++++ E ++AK K++
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRL 1400
Query: 550 HEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQ-----------------KAANRWK 592
E + +E + + E+ L+ + K + WK
Sbjct: 1401 QEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK 1460
Query: 593 ---EETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM-------ANEKVAENEKLIL 642
EET+ E+++ +L +EL + K +E L QLE +++++ + I
Sbjct: 1461 QKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIA 1520
Query: 643 EHQEKANRLQRRLSQAEE 660
E ++ + L++ Q E+
Sbjct: 1521 EGGKQIHELEKIKKQVEQ 1538
Score = 84.0 bits (206), Expect = 4e-16
Identities = 98/487 (20%), Positives = 214/487 (43%), Gaps = 45/487 (9%)
Query: 224 LRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSS 283
++++ ++ K EL + AK +EL L + + V S ++ R +QL +
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 284 IKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEA 343
QLE ++ + A + N L + R+L+ +C+EL+ + + L A
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL---------ELTLA 965
Query: 344 NLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRLTE 399
++K + E K K E++ + ET+++ ++ A T ++ + + +++ LT+
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 400 ELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERS 459
+ L+ + + +G +E ++K + +LE+ R+ G+ L+ + + E
Sbjct: 1026 AKTKLEQQVDDLEGSLE----QEKKLRMDLERAKRKLEGD------LKLAQESTMDMEND 1075
Query: 460 KDDLQLRLTRAE----NRIKQLETDSSEE------ISRYQEMIQKLQNVLESERENCGLV 509
K L +L + E N I ++E + + E I Q I++L +E+ER +
Sbjct: 1076 KQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKA 1135
Query: 510 SEQRLKLQQENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREM 566
+QR L +E +++ + E +E KK + + + + E + +
Sbjct: 1136 EKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195
Query: 567 EDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQ 626
+ +S+ EL + Q+ + ++E +L + +N ++ +S+ K + +++
Sbjct: 1196 RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEA-ISKAKGNLEKMCRS 1254
Query: 627 LEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS-----VITVQRRKAAS 681
LE ++V+E + E Q N L + ++ + A S+QL V + R K AS
Sbjct: 1255 LE---DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 682 LMNLENI 688
+E +
Sbjct: 1312 TQQIEEL 1318
Score = 73.2 bits (178), Expect = 8e-13
Identities = 85/402 (21%), Positives = 186/402 (46%), Gaps = 39/402 (9%)
Query: 294 TIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLE 353
T +E ++ E + + + +AK ELE E+ +++ +N +QL ++ ++ +L +
Sbjct: 848 TEKEMATMKEEFQKTKDELAKSEAKRKELE-EKMVTLLKEKNDLQLQVQS---EADSLAD 903
Query: 354 EKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQG 413
+++ E + K K + +++ T R ++E + + +L +E S L+ + + +
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEE-EEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 414 QIERVIKEKKAVEEELEKIYREGRGNESDYRKL-------EEMHQRFLVSERSKDDLQLR 466
+ +V KEK A E +++ + E G + KL +E HQ+ L ++++D
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 467 LTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKE 526
LT+A+ +++Q D + + +++ L+ + L E + ++ + +QL ++
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 527 TES--------LRKI----ALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSI 574
E + KI A+E Q + K+K E + I+E G E+ E E ++R
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIK----ELQARIEELGEEI---EAERASRAKA 1135
Query: 575 VELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLH------TQELLSQLE 628
+ R L+ + + + EE T SA++ +N K E QKL T + + +
Sbjct: 1136 EKQRSDLSRELEEISERLEEAGGAT-SAQVELNK-KREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 629 MANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS 670
+K A++ + E + R++++L + + + LS
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS 1235
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 107 bits (267), Expect = 4e-23
Identities = 121/637 (18%), Positives = 289/637 (45%), Gaps = 69/637 (10%)
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEV 119
V + + +L +L K GE++ L V + ++ +++ + E L E+
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK---ERDALSLEL 209
Query: 120 GTDIYADDETVRN---LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQI-H 175
+ D+E LQE+LQL EK++ + + ++L+R L + +A+ H
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 176 V----------FESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR 225
+ ++Q ++++L++ +L +Q E Q++ + + EQ I +
Sbjct: 270 LGKELQSVSAKLQAQVEENELWN--RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 226 KKLRQAKLELR----VAVAKVEELTNVTE---DLQGQMKKKEKDVVSAHGREEASDRRLQ 278
+K+R+ + ++R + K E++ E + + +M+++E+ + + + +
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 279 QLQSSIKQLEIRLCVT--IQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNS 336
+ + I++LE ++ I+E + R E + +Q + + E + R E +R +
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE---QEAKMWRQEEKIREQEE 444
Query: 337 MQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISR 396
+E + + + + E++K + EK +E + Q+ I ++E+ K++ + Q +
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK 504
Query: 397 LTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREG---RGNESDYRKLEEMHQRF 453
+ ++ + Q E++ ++++ + E+ EK++R+ R E +R+ E+MH++
Sbjct: 505 IRKQEEKVWR-------QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE 557
Query: 454 LVSERSK-DDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQ 512
+ E K + + ++ R E +I++ E + + +E +K Q E + + EQ
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 513 RLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRN 572
K+Q++ +++R++ E +R+ + T E E + E+ E ++ E E+
Sbjct: 618 EEKIQEQEEKIREQEEKIRE----------QEEMTQEQEEKMGEQ--EEKMCEQEEK--- 662
Query: 573 SIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANE 632
Q++ W++E K E +I + ++ Q+ QE ++ E
Sbjct: 663 ----------MQEQEETMWRQEEK--IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 710
Query: 633 KVAENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669
K+ E E+ + E +EK R + ++ + E R +++
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 747
Score = 82.8 bits (203), Expect = 1e-15
Identities = 91/465 (19%), Positives = 199/465 (42%), Gaps = 56/465 (12%)
Query: 241 KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
K+ TN G E + ++H +EA R +L++ + + I C
Sbjct: 89 KINNGTNPETTTSGGCHSPEDEQKASHQHQEALRR---ELEAQVHTIRILTC-------- 137
Query: 301 LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE-- 358
+ T L+ Q +LE E + I R +S + E S ++K+ +
Sbjct: 138 ---QKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRY 194
Query: 359 -EDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIER 417
E++ K ++ +S + TI T +E+ + ++ + E S +Q+ E + ++ER
Sbjct: 195 IEELTKERDALSLELYRNTI-TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 253
Query: 418 --VIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
++ ++ ++ E + + G+ +S KL+ + + R + ++ R E +I+
Sbjct: 254 AKLLLPQQQLQAEADHL---GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 310
Query: 476 QLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRK--- 532
+ E E+ + +E +K++ E R ++ E+ K++++ + + ++ E +R+
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370
Query: 533 IALEAQKKAKVKISTM-EHEFSIKERGFEVQLREME-----DSNRNSIVELRHLLATQQK 586
+ E ++K + + M E E I+E E ++ E E + R ++R Q++
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKIRE--LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLE------------------ 628
A W++E K + +IR K +K+H QE + + E
Sbjct: 429 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ 488
Query: 629 ----MANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669
EK+ E E+ I + +EK R + ++ + EE+ +++
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/260 (23%), Positives = 114/260 (43%), Gaps = 30/260 (11%)
Query: 444 RKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESER 503
R+LE + K +LQ+ L +++ +KQLE ++ + ISR + K LE
Sbjct: 123 RELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS-WKFAGELE--- 178
Query: 504 ENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQL 563
+ V+ Q+ K + ++L KE ++L +LE + E ++E+ +QL
Sbjct: 179 QALSAVATQKKKADRYIEELTKERDAL---SLELYRNTITDEELKEKNAKLQEK---LQL 232
Query: 564 REMEDSN-RNSIVELRH------LLATQQKAANRWKEETKKLTE-----SAEIRINNLKS 611
E E S + ++ EL+ LL QQ+ K+L A++ N L +
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292
Query: 612 ELS--------RQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAA 663
L+ RQ+ QE +++ EK+ E E+ I E +EK R + + + EE+
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 664 SASQQLSVITVQRRKAASLM 683
+ + + R+ +M
Sbjct: 353 RQEEMMWEKEEKMRRQEEMM 372
Score = 39.7 bits (91), Expect = 0.009
Identities = 56/347 (16%), Positives = 151/347 (43%), Gaps = 48/347 (13%)
Query: 8 LREQNRRLNEDFRRY--QMESFSKYSSVQKAVCQGEGDDTF--ENLVFDQSFLAPLVTEY 63
+REQ ++ E ++ Q E + +++ + E ++ + E + +Q E
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE-------EI 491
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDI 123
+ +++ Q + +KQ ++ Q E + ++ E++ + E+K+ ++
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ-----EEKMWRQEEKIREQEEM 546
Query: 124 YADDETVRNLQEQLQLANQEKTQAVE--LWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
+ ++E + EQ ++ +EK Q E +W+ + ++ K++++ E +I E ++
Sbjct: 547 WREEE---KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQ---EEKIREQEEKR 600
Query: 182 QKDQLFDFQQLTKQLHVTNENMEVTNQQFLKT------VTEQSVIIEQLRKKLRQAKLEL 235
Q+ + +++ KQ E E +Q K + EQ + ++ +K+ + + ++
Sbjct: 601 QEQE----EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656
Query: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTI 295
K++E + +++++EK + + + +Q+ + + + E ++C
Sbjct: 657 CEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC--- 713
Query: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
E++ +E + K E + +E VR R + ++E
Sbjct: 714 -----------EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 107 bits (266), Expect = 5e-23
Identities = 146/679 (21%), Positives = 282/679 (41%), Gaps = 107/679 (15%)
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E D + +L+ + + +Q+ E+K QLE IK K A+ L++ ++
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKA--------KSALAHALQSSRHDCDLLR 1348
Query: 122 DIYADDETVR-NLQEQLQLANQEKTQAVELWQTVS----QELDRLHKLYQEHMTEAQIHV 176
+ Y +++ + LQ + AN E Q ++T + +EL+ K + + +A+ HV
Sbjct: 1349 EQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 177 ---------FESQKQK--DQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR 225
E KQ+ +++ D ++ + ++ + F K + E E+
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468
Query: 226 KKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIK 285
+L ++ E R ++ ++ N E+ Q+ E R + LQ I
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQL--------------ETLKRENKNLQQEIS 1514
Query: 286 QLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN--ERYEAIVRARNSMQLLEEA 343
L ++ + ++L +E++ ELQA E E E E + +++ E
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI-----LRIQLEL 1569
Query: 344 NLQKSQALLEEKQKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRL 397
N KS+ + +K+E+I++MK R V+ DA IR++ + KK+ ++ +
Sbjct: 1570 NQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1629
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
+L+ AE K + L+ R E++ ++ + E
Sbjct: 1630 EIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ----------EDLKEQLAMVE 1679
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQ 517
R + LQ + ++Q T+ S +I+ QE++ + V +N L++ ++ KL+
Sbjct: 1680 RRANLLQAEIEELRATLEQ--TERSRKIAE-QELLDASERVQLLHTQNTSLINTKK-KLE 1735
Query: 518 QENKQLRKETESLRKIALEAQKKAKVKIS--TMEHEFSIKERGFEVQLREMEDSNRNSIV 575
+ Q++ E E + + A A++KAK I+ M E KE+ L M+ + ++
Sbjct: 1736 TDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 576 ELRHLL-ATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV 634
+L+H L +Q A K++ +KL E R+ L+ E+ ++ E + L KV
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKL----EARVRELEGEVESEQKRNVEAVKGLRKHERKV 1851
Query: 635 AE-------NEKLILEHQE----------------------------KANRLQRRLSQAE 659
E + K IL Q+ K R+Q L +AE
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 660 ERAASASQQLSVITVQRRK 678
ERA A Q++ + V+ R+
Sbjct: 1912 ERADIAESQVNKLRVKSRE 1930
Score = 102 bits (255), Expect = 9e-22
Identities = 137/667 (20%), Positives = 282/667 (42%), Gaps = 80/667 (11%)
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDI 123
+K L QL + + E + + ++ + RL +E + + E L +++
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 124 YADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEH----------MTEAQ 173
A + + L+ QL+ + K+ Q+ + D L + Y+E M++A
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 174 IHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQ---QFLKTVTEQSVIIEQLRKKLRQ 230
V + + + + D Q T++L + + Q + ++ V + +E+ +++L+
Sbjct: 1370 SEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 231 AKLELRVAVAKVEELTNVTEDLQGQMKK-----KEKDVVSAHGREEASDRRLQQLQSSIK 285
+L + V + + Q K K+K H EAS + + L + +
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQK-CEETHAELEASQKESRSLSTELF 1486
Query: 286 QLEIRLCVTIQEANQLRTENTHLE--------------KQTRELQAKCNELENERYE--- 328
+++ ++ + L+ EN +L+ K+ EL+ ++E E+ E
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546
Query: 329 AIVRARNSMQLLE--------EANLQKSQALLEEKQKEEDIEKMKETVSRFVQ------D 374
A+ A S++ E E N KS+ + +K+E+I++MK R V+ D
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606
Query: 375 ATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYR 434
A IR++ + KK+ ++ + +L+ AE K + L
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL----- 1661
Query: 435 EGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQK 494
+ R E++ ++ + ER + LQ + ++Q T+ S +I+ QE++
Sbjct: 1662 -----DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ--TERSRKIAE-QELLDA 1713
Query: 495 LQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKI--STMEHEF 552
+ V +N L++ ++ KL+ + Q++ E E + + A A++KAK I + M E
Sbjct: 1714 SERVQLLHTQNTSLINTKK-KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEE 1772
Query: 553 SIKERGFEVQLREMEDSNRNSIVELRHLL-ATQQKAANRWKEETKKLTESAEIRINNLKS 611
KE+ L M+ + ++ +L+H L +Q A K++ +KL E R+ L+
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL----EARVRELEG 1828
Query: 612 ELSRQKLHTQELLSQLEMANEKV-------AENEKLILEHQEKANRLQRRLSQAEERAAS 664
E+ ++ E + L KV E+ K IL Q+ ++LQ ++ + +A
Sbjct: 1829 EVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Query: 665 ASQQLSV 671
A +Q +V
Sbjct: 1889 AEEQSNV 1895
Score = 102 bits (253), Expect = 2e-21
Identities = 137/673 (20%), Positives = 287/673 (42%), Gaps = 92/673 (13%)
Query: 69 ELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYA 125
+L G LK Q+ ++ K QL+ +K+ E S L+ +E + LG ++ I
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIE---DEQALGMQLQKKIKE 1114
Query: 126 DDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--HMTEAQIHVFESQKQK 183
+ L+E+++ + +A + +S+EL+ + + +E T AQI + + ++ +
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 184 DQLF--DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV---- 237
Q D ++ T Q T + + + + EQ ++++++KL + K E+++
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 238 ----------AVAKVEELTNVTEDLQGQMKKKEK-------DVVSAHGREEAS----DRR 276
A +E++ ED ++K KE+ D+ + R + R+
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 277 LQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEA-IVRARN 335
L + + + QL Q+ +L+ + LE++ + A + L++ R++ ++R +
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKSALAHALQSSRHDCDLLREQY 1351
Query: 336 SMQLLEEANLQKSQALLEEK-------------QKEEDIEKMKETVSRFVQDA------- 375
+ +A LQ++ + + Q+ E++E+ K+ +++ +QDA
Sbjct: 1352 EEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 376 ------TIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKE-KKAVEE- 427
+TK+ + N + I + R +AL +KQ ++++ E K+ EE
Sbjct: 1412 NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD----KKQRNFDKILAEWKQKCEET 1467
Query: 428 --ELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEI 485
ELE +E R ++ K++ + E S D L+ L R ++Q +D +E+I
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAY------EESLDQLE-TLKRENKNLQQEISDLTEQI 1520
Query: 486 SRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEA-QKKAKV- 543
+ + I +L+ + + + SE + L++ L E + +I LE Q K++V
Sbjct: 1521 AEGGKRIHELEKIKKQVEQE---KSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577
Query: 544 -KISTMEHEFSIKERGFEVQLREMEDS------NRNSIVELRHLLATQQKAANRWKEETK 596
KI+ + E +R + M+ + +RN + L+ +
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN 1637
Query: 597 KLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS 656
++ A N ++ L +LH + L E E++A E+ Q + L+ L
Sbjct: 1638 RMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 657 QAEERAASASQQL 669
Q E A Q+L
Sbjct: 1698 QTERSRKIAEQEL 1710
Score = 95.1 bits (235), Expect = 2e-19
Identities = 146/680 (21%), Positives = 288/680 (42%), Gaps = 105/680 (15%)
Query: 80 QVGEMKLQLENVIKE-------NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Q+ + K+QLE IKE E +++EL A ++KLE +E+ DI + T+
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELT-AKKRKLE--DECSELKKDIDDLELTLAK 967
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
++++ + E + + + +L K + Q + + Q ++D++ +
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
+L +++E + +Q K + +E+ ++KL +L++A ++ N + L
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEG---DLKLAQESTMDIENDKQQL 1080
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
++KKKE ++ + E QLQ IK+L+ R+ +E R EKQ
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 313 RELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFV 372
+L + E+ + LEEA S + K++E + +KM+ R +
Sbjct: 1141 SDLSRELEEIS--------------ERLEEAGGATSAQIEMNKKREAEFQKMR----RDL 1182
Query: 373 QDATIRTKKEVANTKKQCNIQISRLTEELSALQ-------MECAEKQGQIERVIKEKKAV 425
++AT++ + A +K+ ++ L E++ LQ E +E + +I+ + + V
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETV 1242
Query: 426 EE---ELEKIYREGRGNESDYRKLEEMHQRF---LVSERS---------------KDDLQ 464
+ LEK+ R S+ + EE QR L ++R+ KD L
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302
Query: 465 LRLTRAENRIKQLETDSSEEISRYQEMIQK----LQNVLESERENCGLVSEQRLKLQQEN 520
+L+R KQ T EE+ R E K L + L+S R +C L+ EQ + Q+
Sbjct: 1303 SQLSRG----KQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 521 KQLRK----------------ETESLRKI--ALEAQKKAKVKISTMEHE---FSIKERGF 559
+L++ ET+++++ EA+KK ++ E + K
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 560 EVQLREMEDSNRNSIVELRH----LLATQQKAAN------RWK---EETKKLTESAEIRI 606
E + +++ + ++++ A +K N WK EET E+++
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 607 NNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASAS 666
+L +EL + K +E L QLE + ++ I + E+ +R+ + E+
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538
Query: 667 QQLSVITVQRRKAASLMNLE 686
Q+ S + +A + + E
Sbjct: 1539 QEKSELQAALEEAEASLEHE 1558
Score = 82.4 bits (202), Expect = 1e-15
Identities = 87/454 (19%), Positives = 197/454 (43%), Gaps = 37/454 (8%)
Query: 87 QLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQ 146
QLE + +EN+ L E+ D E+ E G + ++ + V + +LQ A +E
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAE----GGKRIHELEKIKKQVEQEKSELQAALEEAEA 1553
Query: 147 AVELWQ----TVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNEN 202
++E + + EL+++ + E + + ++ ++ + Q T + + N
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRN 1613
Query: 203 MEVT---------NQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQ 253
+ N+ ++ + E LR R + L+ +++ EDL+
Sbjct: 1614 DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN-YRNTQAILKDTQLHLDDALRSQEDLK 1672
Query: 254 GQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTR 313
Q+ E+ E L+Q + S K E L + L T+NT L +
Sbjct: 1673 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1732
Query: 314 ELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED----IEKMKETVS 369
+L+ ++++ E + I ARN+ + ++A + + + EE +KE+D +E+MK+ +
Sbjct: 1733 KLETDISQIQGEMEDIIQEARNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 370 RFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEEL 429
+ V+D R + K QI +L + L+ E +Q + +K + E ++
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKV 1851
Query: 430 EKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQ 489
+++ + + + +L+++ D LQ ++ + + ++ E S+ +S++
Sbjct: 1852 KELTYQTEEDRKNILRLQDL----------VDKLQAKVKSYKRQAEEAEEQSNVNLSKF- 1900
Query: 490 EMIQKLQNVLESERENCGLVSEQRLKLQQENKQL 523
+++Q+ LE E + Q KL+ +++++
Sbjct: 1901 ---RRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 77.4 bits (189), Expect = 4e-14
Identities = 91/487 (18%), Positives = 204/487 (41%), Gaps = 45/487 (9%)
Query: 224 LRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSS 283
++++ + K EL AK +EL L + + V + ++ R QL +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 284 IKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEA 343
QLE ++ + A N L + R+L+ +C+EL+ + + L A
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---------ELTLA 966
Query: 344 NLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRLTE 399
++K + E K K E++ + ET+++ ++ A ++ + + +++ LT+
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026
Query: 400 ELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERS 459
L+ + + +G +E ++K + +LE+ R+ G+ L+ + + E
Sbjct: 1027 AKIKLEQQVDDLEGSLE----QEKKIRMDLERAKRKLEGD------LKLAQESTMDIEND 1076
Query: 460 KDDLQLRLTRAENRIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCGLV 509
K L +L + E + L++ +E I Q I++L+ +E+ER +
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 510 SEQRLKLQQENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREM 566
+QR L +E +++ + E +E KK + + M + E +
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 567 EDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQ 626
+ +S+ EL + Q+ + ++E ++ + +N+++ +S+ K + +++
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET-VSKAKGNLEKMCRA 1255
Query: 627 LEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS-----VITVQRRKAAS 681
LE ++ E+ E Q N L + ++ + + S+QL V + R K A
Sbjct: 1256 LEDQLSEIKTKEE---EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAF 1312
Query: 682 LMNLENI 688
+E +
Sbjct: 1313 TQQIEEL 1319
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 106 bits (265), Expect = 6e-23
Identities = 155/764 (20%), Positives = 322/764 (42%), Gaps = 105/764 (13%)
Query: 3 AEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
A+I +R+++ E+ Q+E ++ + + QG D E L + L + E
Sbjct: 1192 AQIQDMRQRHATALEELSE-QLEQAKRFKANLEKNKQGLETDNKE-LACEVKVLQQVKAE 1249
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
+ +L+ Q++ +V E + ++ +L +EL + EA G + D
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 123 IYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQ 182
+ + +++ QE LQ ++K + + +E + L + QE EA+ ++ +KQ
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE-QQEEEEEARKNL---EKQ 1365
Query: 183 ----KDQLFDFQQLTKQLHVTNENMEVTNQQFLKT-------VTEQSVIIEQLRKKLRQA 231
+ QL D ++ T E++E ++ LK + E+++ ++L K +
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 232 KLELRVAVAKVEELTNVTEDLQGQMKK----------------KEKDVVSAHGRE----- 270
+ EL ++ V +L+ + KK +E+D A RE
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 271 --------------EASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQ 316
E +R+ +QL++ ++ L + ++L LE+Q E++
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 317 AKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEE--KQKEEDIEKMKETVSRFVQD 374
+ ELE+E ++A +L E N+Q +A E + ++E E+ K + + V++
Sbjct: 1546 TQLEELEDE-----LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 375 ATIRTKKE------VANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEE 428
+ E +KK+ I + L ++ A E Q+ ++ + K + E
Sbjct: 1601 LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 429 LEK-------IYREGRGNESDYRKLE----EMHQRFLVSERSKDDLQLRLTRAENRIKQL 477
LE+ I+ + + +E + LE ++ + SER++ + + I
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 478 ETDSS---EEISRYQEMIQKLQNVLESERENCGLVSEQ----RLKLQQENKQLRKETESL 530
+ S +E R + I +L+ LE E+ N L++++ L++ N +L E +
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 531 RKI-----ALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQ 585
+K LE Q K ++K E E ++K + F+ + +E + + E A ++
Sbjct: 1781 QKSDNARQQLERQNK-ELKAKLQELEGAVKSK-FKATISALE-AKIGQLEEQLEQEAKER 1837
Query: 586 KAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQ 645
AAN KL E ++ + ++ ++ H + Q+E AN ++ + ++ + E +
Sbjct: 1838 AAAN-------KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 646 EKANR-------LQRRLSQAEERAASASQQLSVITVQRRKAASL 682
E+A R LQR L A E S+++S + + R+ +
Sbjct: 1891 EEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
Score = 106 bits (264), Expect = 8e-23
Identities = 152/702 (21%), Positives = 304/702 (43%), Gaps = 99/702 (14%)
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKE---------NERLHSELKDAVEKKLEAFP 114
D +L Q+ Q Q+ E+KLQL +E +E LH V ++L+A
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 115 LGTEVGTDIYAD-------DETVRNLQEQLQLANQEKTQAV-------ELWQTVSQELDR 160
E+ D ++ ++ R+L E+L+ E + EL QE+
Sbjct: 1121 --AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 161 LHKLYQEHMT--EAQI------HVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQF-- 210
L K +E EAQI H ++ +QL ++ L + +E N++
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 211 -LKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGR 269
+K + + E RKKL EL AKV E + +L + K + ++ +
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELH---AKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 270 EEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEA 329
E ++++ + LE +L T + + + +L + R+L+ + N L+ ++ E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 330 IVRARNSMQLLEEANLQKSQALLEEKQKEED----IEKMKETVSRFVQDATIRTKK---- 381
+N LE+ L L + K+K +D IE ++E + ++DA +++
Sbjct: 1356 EEARKN----LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 382 -----EVANTKKQCNIQISRLTEELSALQMECA---EKQGQIERVIKEKKAVE----EEL 429
++ TK + ++ LT +L + + +KQ + ++++ E+K++ EE
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 430 EKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQ 489
++ E R E+ L + L +K++ E + KQL D + +S
Sbjct: 1472 DRAEAEAREKETKALSLARALEEAL---EAKEEF-------ERQNKQLRADMEDLMSSKD 1521
Query: 490 EMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQK-KAKVK--IS 546
++ + + + +S+R V E R +L++ +L+ ++ ++ + Q KA+ + +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 547 TMEHEFSIKERGFEVQLREMED--------------SNRNSIVELRHLLATQQKAANRWK 592
T + + K+R Q+RE+E S + ++L+ L A Q +AAN+ +
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA-QIEAANKAR 1640
Query: 593 EETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEK---AN 649
+E K + ++ + + EL + E+ +Q + + +K+ E IL+ QE+ +
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 650 RLQRRLSQ-----AEERAASASQQLSVITVQRRKAASLMNLE 686
R +R Q A+E SAS + +++ +RR A + LE
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Score = 99.4 bits (246), Expect = 1e-20
Identities = 132/643 (20%), Positives = 291/643 (45%), Gaps = 66/643 (10%)
Query: 80 QVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQL 139
+V E + ++E ++E ER H +L + EK + A L E T+++A+ E +R +L
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLE--EKNILAEQLQAE--TELFAEAEEMR---ARLAA 915
Query: 140 ANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKD------QLFDFQQLT 193
QE + + ++ +E + +++ Q + Q H+ + ++Q D Q +++T
Sbjct: 916 KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT 975
Query: 194 KQLHV--TNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVA--VAKVEELTNV- 248
+ + E + + Q K + E+ ++ +++ + Q E A +AK+ V
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 249 TEDLQGQMKKKEK---DVVSAHGREEASDRRLQ----QLQSSIKQLEIRLCVTIQEAN-- 299
DL+ ++KK+EK ++ A + + LQ +LQ+ I +L+++L +E
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095
Query: 300 QLRTENTHLEKQ-----TRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEE 354
R ++ L K RELQA+ EL+ E +E+ +RN + + ++ +AL E
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQ-EDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Query: 355 KQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQ 414
+ D ++ + + KK + K QI + + + E +E+ Q
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 415 IER----VIKEKKAVEEELE------KIYREGRGNESDYRK-----LEEMHQRFLVSERS 459
+R + K K+ +E + + K+ ++ + RK ++E+H + +R
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 460 KDDLQLRLTRAENRIKQLET---DSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKL 516
+ +L + ++ +N + + T ++ ++ ++ + L++ L+ +E + Q+L L
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
Query: 517 QQENKQLRKETESL---RKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNS 573
+QL +E SL ++ EA+K + ++ ++ + + ++ + L +E S
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE-----S 1389
Query: 574 IVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKL---HTQELLSQLEMA 630
+ E + L +A ++ EE + E N L+ EL + H +++ S LE
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 631 NEK----VAENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669
+K +AE + + + E+ +R + + E +A S ++ L
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Score = 64.3 bits (155), Expect = 4e-10
Identities = 61/277 (22%), Positives = 126/277 (45%), Gaps = 16/277 (5%)
Query: 414 QIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENR 473
Q+ R +E +A +EEL K+ + E + ++E HQ+ L + + T
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 474 IKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQE----NKQLRKETES 529
+++ + + +E++ L++ +E E E ++ ++ K+Q +QL +E +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 530 LRKIALEAQKKAKVKISTMEHEFSIKE---RGFEVQLREMEDSNRNSIVELRHLLATQQK 586
+K+ LE + A+ KI ME E + E F + + MED I E LA +++
Sbjct: 966 RQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED----RIAECSSQLAEEEE 1020
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQE 646
A + K+ E+ I++L+ L +++ QEL + + + + I E Q
Sbjct: 1021 KA----KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 647 KANRLQRRLSQAEERAASASQQLSVITVQRRKAASLM 683
+ + L+ +L++ EE A + T+ + A ++
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Score = 46.6 bits (109), Expect = 8e-05
Identities = 40/191 (20%), Positives = 86/191 (45%), Gaps = 17/191 (8%)
Query: 514 LKLQQENKQLRKETESLRKIALEAQKKAKVKISTME--HEFSIKERGFEVQLREMEDSNR 571
L++ ++ ++L+ + E L K+ E Q K + ++ ME H+ ++E+ + + E
Sbjct: 845 LQVTRQEEELQAKDEELLKVK-EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 572 NSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLE--- 628
E+R LA +++ + + E E R L++E + + H Q+L QL+
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 629 -----------MANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRR 677
A K+ + E+ IL +++ ++ + E+R A S QL+ + +
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 678 KAASLMNLENI 688
A + N + +
Sbjct: 1024 NLAKIRNKQEV 1034
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 106 bits (264), Expect = 8e-23
Identities = 138/672 (20%), Positives = 277/672 (41%), Gaps = 74/672 (11%)
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
++K L QL + + E + + + + RLH+E + + E + +++
Sbjct: 1249 FEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG 1308
Query: 123 IYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEH----------MTEA 172
A + + L+ QL+ + K+ Q+ + D L + Y+E M++A
Sbjct: 1309 KQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKA 1368
Query: 173 QIHV-----------------FESQKQK--DQLFDFQQLTKQLHVTNENMEVTNQQFLKT 213
V E K+K +L D ++ + ++ ++E T Q+
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNE 1428
Query: 214 VTEQSVIIEQ-------LRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSA 266
V + + +E+ L KK R L K EE E Q + + ++
Sbjct: 1429 VEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKV 1488
Query: 267 HGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENER 326
E S L+ L+ K L+ + ++ + LEK ++L + +EL+
Sbjct: 1489 KNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSL 1548
Query: 327 YEAIVRARNS----MQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQ------DAT 376
EA + +++ E N KS+ + +K+E+++++K R V+ DA
Sbjct: 1549 EEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAE 1608
Query: 377 IRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREG 436
IR++ + KK+ ++ + +L+ + AE + K + L+
Sbjct: 1609 IRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAI--- 1665
Query: 437 RGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQ 496
RG + +L + +R + + ++L+ L R E K E QE++ +
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE----------QELLDASE 1715
Query: 497 NVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKI--STMEHEFSI 554
V +N L++ ++ KL+ + Q++ E E + + A A++KAK I + M E
Sbjct: 1716 RVQLLHTQNTSLINTKK-KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 555 KERGFEVQLREMEDSNRNSIVELR-HLLATQQKAANRWKEETKKLTESAEIRINNLKSEL 613
KE+ L M+ + ++ +L+ L +Q A K++ +KL E R+ L+SE+
Sbjct: 1775 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL----EARVRELESEV 1830
Query: 614 SRQKLHTQELLSQLEMANEKV-------AENEKLILEHQEKANRLQRRLSQAEERAASAS 666
++ H E + L +V E+ K IL Q+ ++LQ ++ + +A A
Sbjct: 1831 ESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAE 1890
Query: 667 QQLSVITVQRRK 678
+Q +V + RK
Sbjct: 1891 EQSNVNLAKFRK 1902
Score = 102 bits (254), Expect = 1e-21
Identities = 144/673 (21%), Positives = 277/673 (41%), Gaps = 95/673 (14%)
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E D + +L+ + + +Q+ E+K QLE K L L+ A ++
Sbjct: 1297 EKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD--------CDLLR 1348
Query: 122 DIYADDETVR-NLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQ 180
+ Y +++ + LQ + AN E Q W+T E D + + E + EA+ +
Sbjct: 1349 EQYEEEQEAKAELQRGMSKANSEVAQ----WRT-KYETDAIQRT--EELEEAK------K 1395
Query: 181 KQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQ-------LRKKLRQAKL 233
K +L D ++ + ++ ++E T Q+ V + + +E+ L KK R
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 234 ELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCV 293
L K EE E Q + + ++ E S L+ L+ K L+ +
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 294 TIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNS----MQLLEEANLQKSQ 349
++ + LEK ++L + +EL+ EA + +++ E N KS+
Sbjct: 1516 LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSE 1575
Query: 350 ALLEEKQKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRLTEELSA 403
+ +K+E+++++K R V+ DA IR++ + KK+ ++ + +L+
Sbjct: 1576 IDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNH 1635
Query: 404 LQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDL 463
+ AE + K + L+ R G + +L + +R + + ++L
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIR---GQDDLKEQLAMVERRANLMQAEVEEL 1692
Query: 464 QLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQL 523
+ L R E K E QE++ + V +N L++ ++ KL+ + Q+
Sbjct: 1693 RASLERTERGRKMAE----------QELLDASERVQLLHTQNTSLINTKK-KLETDISQI 1741
Query: 524 RKETESLRKIALEAQKKAKVKIS--TMEHEFSIKERGFEVQLREMEDSNRNSIVELR-HL 580
+ E E + + A A++KAK I+ M E KE+ L M+ + ++ +L+ L
Sbjct: 1742 QGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1801
Query: 581 LATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAE---- 636
+Q A K++ +KL E R+ L+SE+ ++ H E + L +V E
Sbjct: 1802 DEAEQLALKGGKKQIQKL----EARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ 1857
Query: 637 ---NEKLILEHQE----------------------------KANRLQRRLSQAEERAASA 665
+ K IL Q+ K +LQ L +A+ERA A
Sbjct: 1858 TEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIA 1917
Query: 666 SQQLSVITVQRRK 678
Q++ + V+ R+
Sbjct: 1918 ESQVNKLRVKSRE 1930
Score = 100 bits (248), Expect = 6e-21
Identities = 144/677 (21%), Positives = 275/677 (40%), Gaps = 119/677 (17%)
Query: 80 QVGEMKLQLENVIKE-------NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Q+ + K+QLE IKE E +++EL A ++KLE +E+ DI + T+
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELT-AKKRKLE--DECSELKKDIDDLELTLAK 967
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
++++ + E + + + +L K + Q + + Q ++D++ +
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
+L +++E + +Q K + +E+ ++KL +L++A + N + L
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEG---DLKLAQESTMDTENDKQQL 1080
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
++KKKE ++ + G+ E QLQ IK+L+ R+ +E R EKQ
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 313 RELQAKCNELENERYEA--IVRARNSMQLLEEANLQKSQALLEE---------------- 354
+L + E+ EA A+ M EA QK + LEE
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH 1200
Query: 355 --------------KQKEEDIEKMKETVSRFVQDATIR---TKKEVANTKKQCNI---QI 394
++ ++ +EK K + + D K AN +K C Q+
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQL 1260
Query: 395 S----------RLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYR 444
S RL ELSA + + G+ R + EK A+ +L RG ++ +
Sbjct: 1261 SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL------SRGKQAFTQ 1314
Query: 445 KLEE----------------------------MHQRFLVSERSKDDLQLRLTRAENRIKQ 476
++EE + +++ + +K +LQ +++A + + Q
Sbjct: 1315 QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 477 ----LETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRK 532
ETD+ + +E +KL L+ E+ V+ + L++ ++L+ E E L
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL-M 1433
Query: 533 IALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWK 592
I +E A + + K+R F+ L E + + EL QK +
Sbjct: 1434 IDVERSNAACIALDK-------KQRNFDKVLAEWKQKYEETQAELE----ASQKESRSLS 1482
Query: 593 EETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQ 652
E K+ + E +++L++ L R+ + Q+ +S L E++AE K I E ++ +L
Sbjct: 1483 TELFKVKNAYEESLDHLET-LKRENKNLQQEISDL---TEQIAEGGKHIHELEKVKKQLD 1538
Query: 653 RRLSQAEERAASASQQL 669
S+ + A L
Sbjct: 1539 HEKSELQTSLEEAEASL 1555
Score = 93.6 bits (231), Expect = 5e-19
Identities = 129/656 (19%), Positives = 277/656 (42%), Gaps = 81/656 (12%)
Query: 59 LVTEYDKHLGELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPL 115
L + ++ +L G LK Q+ + K QL +K+ E S L+ +E + L
Sbjct: 1048 LCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE---DEQAL 1104
Query: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--HMTEAQ 173
++ I + L+E+++ + +A + +S+EL+ + + +E T AQ
Sbjct: 1105 AIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164
Query: 174 IHVFESQKQKDQLF--DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQA 231
I + + ++ + Q D ++ T Q T + + + + EQ ++++++KL +
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 232 KLELRV--------------AVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRL 277
K EL++ A A E++ ED ++K KE++ A RL
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 278 QQLQSSI-KQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNS 336
+QL+ + + Q + + +E+ R+L+ + + ++ A+ AR+
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE-TKAKSTLAHALQSARHD 1343
Query: 337 MQLLEEANLQKSQALLE-EKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQIS 395
LL E ++ +A E ++ + ++ + +++ DA RT +E+ KK+ ++
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQ 1402
Query: 396 RLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRF-- 453
E + A+ +CA + K K+ ++ E+E + + + + L++ + F
Sbjct: 1403 DAEEHVEAVNSKCASLE-------KTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 454 -LVSERSK-DDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSE 511
L + K ++ Q L ++ + L T+ + + Y+E + L+
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET-------------- 1501
Query: 512 QRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNR 571
L++ENK L++E L + E K HE ++ + + E++ S
Sbjct: 1502 ----LKRENKNLQQEISDLTEQIAEGGKHI--------HELEKVKKQLDHEKSELQTSLE 1549
Query: 572 NSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMAN 631
+ L H EE K L ++ +N +KSE+ R+ E L QL+ +
Sbjct: 1550 EAEASLEH-------------EEGKIL--RIQLELNQVKSEIDRKIAEKDEELDQLKRNH 1594
Query: 632 EKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLEN 687
+V E+ + L+ + ++ R+ + E + ++ + R+ A +L NL N
Sbjct: 1595 LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN-EMEIQLNHANRQAAEALRNLRN 1649
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/487 (19%), Positives = 208/487 (42%), Gaps = 45/487 (9%)
Query: 224 LRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSS 283
++++ + K EL AK +EL L + + V + ++ R QL +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKT 915
Query: 284 IKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEA 343
QLE ++ + A N L + R+L+ +C+EL+ + + L A
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---------ELTLA 966
Query: 344 NLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRLTE 399
++K + E K K E++ + ET+++ ++ A ++ + + +++ LT+
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTK 1026
Query: 400 ELSALQMECAEKQGQIER-------VIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQR 452
+ L+ + + +G +E+ + + K+ +E +L+ E+D ++L E ++
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKK 1086
Query: 453 FLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQ 512
E +LQ ++ + QL+ ++I Q I++L+ +E+ER + +Q
Sbjct: 1087 ---KEFEMSNLQGKIEDEQALAIQLQ----KKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 513 RLKLQQENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDS 569
R L +E +++ + E +E KK + + M + E +
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKK 1199
Query: 570 NRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSEL---SRQKLHTQELLSQ 626
+ +S+ EL + + Q+ + ++E +L ++ IN+L S + S+ K + +++
Sbjct: 1200 HADSVAELGEQIDSLQRVKQKLEKEKSEL----KMEINDLASNMETVSKAKANFEKMCRT 1255
Query: 627 LEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS-----VITVQRRKAAS 681
LE ++ E+ E Q N L + ++ + S+QL V + R K A
Sbjct: 1256 LEDQLSEIKTKEE---EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312
Query: 682 LMNLENI 688
+E +
Sbjct: 1313 TQQIEEL 1319
Score = 80.5 bits (197), Expect = 5e-15
Identities = 87/467 (18%), Positives = 207/467 (44%), Gaps = 53/467 (11%)
Query: 88 LENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQA 147
LE + +EN+ L E+ D E+ E G I+ ++ + L + ++ +T
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEG-------GKHIHELEKVKKQLDHE---KSELQTSL 1548
Query: 148 VELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTN 207
E ++ E ++ ++ E + + + + +KD+ D QL + E+M+ T
Sbjct: 1549 EEAEASLEHEEGKILRIQLE-LNQVKSEIDRKIAEKDEELD--QLKRNHLRVVESMQSTL 1605
Query: 208 QQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSA- 266
+++ + I +++ L + +++L A + E + QG +K + + A
Sbjct: 1606 DAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAI 1665
Query: 267 HGREEASD------RRLQQLQSSIKQL--------------EIRLCVTIQEANQLRTENT 306
G+++ + RR +Q+ +++L E L + L T+NT
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT 1725
Query: 307 HLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED----IE 362
L ++L+ ++++ E + + ARN+ + ++A + + + EE +KE+D +E
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLE 1784
Query: 363 KMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEK 422
+MK+ + + V+D +R + K QI +L + L+ E +Q +K
Sbjct: 1785 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGL 1844
Query: 423 KAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSS 482
+ E ++++ + + + +L+++ D LQ ++ + + ++ E S+
Sbjct: 1845 RKHERRVKELTYQTEEDRKNILRLQDL----------VDKLQTKVKAYKRQAEEAEEQSN 1894
Query: 483 EEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
++++ +KLQ+ LE +E + Q KL+ +++++ + S
Sbjct: 1895 VNLAKF----RKLQHELEEAKERADIAESQVNKLRVKSREVHTKVIS 1937
>gi|28269672 serologically defined colon cancer antigen 8 [Homo
sapiens]
Length = 713
Score = 106 bits (264), Expect = 8e-23
Identities = 131/634 (20%), Positives = 263/634 (41%), Gaps = 94/634 (14%)
Query: 56 LAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL 115
L + + +++ L ++K+ ++++ MK +++ V+ ENE L +LK +
Sbjct: 118 LVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ-------- 169
Query: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIH 175
+ET+R QT+ +H + ++ +
Sbjct: 170 -----------EETLRE-------------------QTLLDASGNMHNSWITTGEDSGVG 199
Query: 176 VFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLEL 235
+ DF + E +E+ LK E+ IE+ + K + L
Sbjct: 200 ETSKRPFSHDNADFGKAAS----AGEQLELEK---LKLTYEEKCEIEESQLKFLRNDLA- 251
Query: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTI 295
E EDL+ Q+K KE +++A+ L+ Q + V +
Sbjct: 252 --------EYQRTCEDLKEQLKHKEF-LLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM 302
Query: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355
Q +L E L +++ + + A + + +Q+ EEAN +K++AL++
Sbjct: 303 QTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCD 362
Query: 356 QKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQI 415
Q +++E+ E + + + + E KK+ + + ++ L A+ + Q+
Sbjct: 363 QLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQV 422
Query: 416 ERVIKEKKAVEEELEKIYREGRGNESDYRKL-EEMHQRFLVSERSKDDLQLRLTRAENRI 474
E+V KEK + +LE+I + E D K+ EM + + KD+ AE
Sbjct: 423 EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDE-------AEKEH 475
Query: 475 KQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIA 534
++ ++ ++ + I+KL+ L+ S+Q L+ +Q+ L +E E LR
Sbjct: 476 REFRAKTNRDLEIKDQEIEKLRIELDE--------SKQHLEQEQQKAALARE-ECLRLTE 526
Query: 535 LEAQKKAKVKISTMEHE-----FS--IKERGFEVQLREMEDSNRNSIVELRH-------- 579
L + + ++ ++ E + FS K + + Q RE E + + +E +H
Sbjct: 527 LLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQY 586
Query: 580 -LLATQQKAANRWKEETKKLTESAEIRINNLKSE---LSRQKLHTQELLSQLEMANEKVA 635
LL +Q + KEE L + E +SE LS++K +T + L +L+ NE
Sbjct: 587 LLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE--- 643
Query: 636 ENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669
E E+ ++H +++RL Q ++ + + +QQL
Sbjct: 644 ELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQL 677
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 105 bits (262), Expect = 1e-22
Identities = 150/713 (21%), Positives = 309/713 (43%), Gaps = 90/713 (12%)
Query: 3 AEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
A ++ L+E+N L E + +K Q E + + DQ V E
Sbjct: 561 AVLNQLQEKNHTLQEQVTQL----------TEKLKNQSESHKQAQENLHDQ------VQE 604
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
HL ++ + V E+ QL ++ +L ++K E L A T D
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 123 IYADDETVRN-LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQK 181
+ +T +N LQ++ Q N+ TQ L Q ++ D+ QEH ++ + H+ E
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQ---LDQVTAKLQDK-----QEHCSQLESHLKE--- 713
Query: 182 QKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVA- 240
K++ +Q T++L + +E + + +K EQ++ Q +++L LELR
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLE-VKASKEQALQDLQQQRQLN-TDLELRATELS 771
Query: 241 -KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEAN 299
++E + + ++KK + + S + + Q L+ + L + +E N
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN 831
Query: 300 -QLRTENTHLEKQTRELQAKCNEL---ENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355
+++T T L+K E +A EL +++ + +NS E+ N + A+L
Sbjct: 832 NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL--- 888
Query: 356 QKEEDIEKMKETVSRFVQ---DATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQ 412
D+EK + + +Q + T++ +KE+ + ++ +L EL+++Q + + Q
Sbjct: 889 ----DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 413 GQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAEN 472
+++ KE++ ++ + ++ + +E +++E + ++ K +L EN
Sbjct: 945 NTLKQNEKEEQQLQGNINELKQS---SEQKKKQIEALQGELKIAVLQKTEL-------EN 994
Query: 473 RIKQLETDSSEEISRYQEMIQKLQNVLESE-------------RENCGLVSEQRLKLQQE 519
+++Q T +++E++ +E I LQN E RE+ L + Q LK +E
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 520 NKQLRKETESLRKIALEAQKK----AKVKISTMEHEFSIKERGFEVQLREMED------- 568
L +E + + Q K K +T+E + + KE+ + + + ++D
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 569 ------SNRNSIVELRHLLATQQKAANRWKEETK--KLTESAEI-RINNLKSELSRQKLH 619
+ ++ + E+ + Q+K + EE K KL EI + + K L +QKL
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 620 TQELLSQLEMANEKVAENEKLILEHQEK-ANRLQRRLSQAEERAASASQQLSV 671
Q L+ A E+ N++++ + +K L++ + E + S ++ V
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Score = 98.6 bits (244), Expect = 2e-20
Identities = 166/770 (21%), Positives = 325/770 (42%), Gaps = 119/770 (15%)
Query: 3 AEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
A I LR + + ++ Y E SSV + + + ENL+ + L +
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ--TLTENLLKKEQDYTKLEEK 324
Query: 63 YDKH-LGELNGQLKYYQKQVGEMKLQLENVIKENE--RLHSELKDAVEKKLEAFPLGTEV 119
+++ + + N Q +QK + +LQ E R+H EL + E + +EV
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
Query: 120 GTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFES 179
T + LQ+Q + Q Q + E+++LH E TE Q+
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQ-------LQSEINQLHSKLLE--TERQLGEAHG 435
Query: 180 Q-KQKDQLFDFQQLTKQLHVTNENMEVTN--QQFLKTVTEQSVIIEQLRKKLRQAKLELR 236
+ K++ QL + + K+ V + ++++ +Q + VT + + QL K +Q + +
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 237 V---AVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCV 293
+ AK+ E N E + Q+ K++ + + + S + L+ + L ++
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 294 TIQEA---NQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQ- 349
E NQL+ +N L++Q +L K +A + +Q ++A+L+ +Q
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE-QKAHLRAAQD 614
Query: 350 --ALLEEKQKE--EDIEKMKETVSRFVQDATIRTKKEV------ANTKKQCNIQ------ 393
LE E + + KE VS+ D I+ K E+ A T ++ ++Q
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQL--DIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 394 ----------ISRLTEELSALQMECAEKQ---GQIERVIKEKK----AVEEELEKIYREG 436
++++T +L + + +KQ Q+E +KE K ++E++ E++ +
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 437 RGNESDYRKL----EEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMI 492
+ E+D ++ E+ Q + DL+LR T KQLE + E +S + +
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS---KQLEMEK-EIVSSTRLDL 788
Query: 493 QKLQNVLESERENCGLVSEQRLKLQQENKQLRKETE---------------SLRKIALEA 537
QK LES ++ E++ L+Q+ + L +ET+ L+K+ +E
Sbjct: 789 QKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME- 847
Query: 538 QKKAKVKISTMEHEFSIKERGFEVQLREMEDSNR----------NSIVELRHLLATQQKA 587
++ ++ST++ + S + E E N+ + EL+H L Q +
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 588 ANRWKEETKKLTESAEIRINNLKSELS---RQKLHTQELLSQLEMANEKVAEN------- 637
+ ++E KK E + + LK EL+ Q + Q L Q E +++ N
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 638 ---------------EKLILEHQEKANRLQRRLSQAEERAASASQQLSVI 672
+ +L+ E N+LQ++L+QA + A+ +++SV+
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Score = 88.2 bits (217), Expect = 2e-17
Identities = 140/658 (21%), Positives = 281/658 (42%), Gaps = 95/658 (14%)
Query: 80 QVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQL 139
++ ++ QLE EN + ++KD E+K A L TE+ DI + + R+L+E +
Sbjct: 136 ELQSLEQQLEEAQTENFNI-KQMKDLFEQK--AAQLATEIA-DIKSKYDEERSLREAAEQ 191
Query: 140 ANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVT 199
T+ + TV Q+L +L Q E + + Q L D L ++
Sbjct: 192 KVTRLTEELNKEATVIQDLKT--ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE-- 247
Query: 200 NENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAV-------AKVEELTNVTEDL 252
+E ++ ++ I QLR +L + E+ V V + V ELT + L
Sbjct: 248 SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
Query: 253 QGQMKKKEKDVVSA---HGREEASDRRLQ-----------QLQSSIKQLEI---RLCVTI 295
+ KKE+D H E S + +Q QLQS + E R+ V +
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 296 -----------QEANQLRTENTHLE------KQTRE--------LQAKCNELENERYEAI 330
+E +++ T+ HL+ +Q RE LQ++ N+L ++ E
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 331 VRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQC 390
+ + L+E S+ L++ KE+ + ++ +SR + + K++V N+
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMD---KEQQVADLQLKLSRLEE----QLKEKVTNS---- 476
Query: 391 NIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMH 450
+ L +L + + E+Q + + + + +LE++ R+ + + LE +
Sbjct: 477 ----TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 451 QR----FLVSERSKDDLQLRLTRAENR---IKQLETDSSEEISRYQEMIQKLQNVLESER 503
Q+ + E+ ++DL ++ E + QL+ + + ++ +KL+N ES +
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 504 ---ENC-GLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGF 559
EN V EQ+ L+ ++ S+ ++ + ++K K+S ++ + K
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL-NESKEKVSQLDIQIKAKTE-- 649
Query: 560 EVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLH 619
L E + +L++ L T Q A ++E K+T +++ + ++L ++ H
Sbjct: 650 --LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT----TQLDQVTAKLQDKQEH 703
Query: 620 TQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRR 677
+L S L+ EK E+ + +E ++++ + + E AS Q L + QR+
Sbjct: 704 CSQLESHLKEYKEKYLSLEQ---KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Score = 84.3 bits (207), Expect = 3e-16
Identities = 142/667 (21%), Positives = 274/667 (41%), Gaps = 99/667 (14%)
Query: 10 EQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGE 69
+Q R+LN D E SK ++K + T +L L + + K E
Sbjct: 754 QQQRQLNTDLELRATE-LSKQLEMEKEIVSS----TRLDLQKKSEALESIKQKLTKQEEE 808
Query: 70 LNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT---DIYAD 126
+ ++ E K+Q E + N R+ + + + + K+E L TE+ T +
Sbjct: 809 KQILKQDFETLSQETKIQHEEL---NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 127 DETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFES-QKQKD- 184
++++N + + + NQ+ A+ + +EL ++ E+ + Q + +S +K+K+
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 185 ------QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVA 238
+L Q+ Q T + E QQ + E EQ +K++ + EL++A
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 239 VAKVEELTN-----VTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCV 293
V + EL N +T+ Q +KEK V + E+ S +QLQS E L
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK-SQETFKQLQSDFYGRESELLA 1044
Query: 294 TIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLE 353
T Q+ L++ L +L + N++ N+ + I + + LE+ + +K Q L E
Sbjct: 1045 TRQD---LKSVEEKLSLAQEDLISNRNQIGNQN-KLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 354 EKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQG 413
+ +DI+K K + + + + E+ K + +I++L EEL + ++E
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLE------ 1153
Query: 414 QIERVIKEKKAVEEELE-KIYREGRGNESDYR-KLEEMHQRFLVSERSKDDLQLRLTRAE 471
I+ + K A + ++ K+ +G+ + + E+ +Q+ L + K++ +L+ E
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE 1213
Query: 472 NRIKQLETDSSEEIS--RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
K +E+ +++E KL + + EN G V +KE +S
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV--------------KKEWQS 1259
Query: 530 LRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAAN 589
++ E +K+ +LR +A +
Sbjct: 1260 SQRRVSELEKQTD---------------------------------DLRGEIAVLEATVQ 1286
Query: 590 RWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVA------ENEKLILE 643
++E + L E LK E +KL T+ L Q ++ N A EN+ L ++
Sbjct: 1287 NNQDERRALLERC------LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Query: 644 HQEKANR 650
H + NR
Sbjct: 1341 HTQALNR 1347
Score = 68.6 bits (166), Expect = 2e-11
Identities = 98/436 (22%), Positives = 192/436 (44%), Gaps = 55/436 (12%)
Query: 288 EIRLCVTIQEANQLRTENTHLEKQTRELQAKCNEL--ENERYEAIVRARNSMQLL---EE 342
E L + + LR E L+ +E + EL E E+Y+ + + L
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 343 ANLQKSQALLEEKQKEE-DIEKMKETVSR-----FVQDATIRTK-KEVANTKKQCNIQIS 395
A LQ + LEE Q E +I++MK+ + + A I++K E + ++ +++
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 396 RLTEELSA-------LQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEE 448
RLTEEL+ L+ E ++ G + + +K+ V+ + D LE
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ----------TLMDNMTLER 244
Query: 449 MHQRFLVSERSKDD---LQLRLTRAENRIKQLETDSS---EEISRYQEMIQKLQNVLESE 502
+ SE+ KD+ LQ + +E I QL ++ + +E++ Y + +QKL++ +
Sbjct: 245 ERE----SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 503 RENCGLVSEQRLKLQQENKQLRKE--TESLRKIALEAQKKAK-VKISTMEHEFSIKERGF 559
+ ++E LK +Q+ +L ++ ES+ K ++A K + ++ S E
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 560 E---VQLREMEDSNRNSIVELRHL------LATQQKAANRWKEETKKLTESAEIRINNLK 610
V+L E ++ + EL + L + K + +EE ++ + IN L
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 611 SELSRQKLHTQE----LLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASAS 666
S+L + E L Q ++++EK+ + E+ + + Q K +RL+ +L + +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 667 QQLSVITVQRRKAASL 682
QL Q ++ +L
Sbjct: 481 HQLDKTKQQHQEQQAL 496
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/310 (21%), Positives = 133/310 (42%), Gaps = 21/310 (6%)
Query: 29 KYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYD--KHLGELNGQLKYYQKQVGEMKL 86
K S Q+ + +N + + A E D K +L + K Q E L
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 87 QLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQ 146
+ + ++ E +L + ++ E L E+ + + + NL++ QL Q+K +
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 147 AVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLF-DFQQLTKQLHVTNENMEV 205
+ + D L ++ QI + +K++++L +F + +LH + EV
Sbjct: 1175 -------LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 206 TNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVS 265
++ + + ++ I L + L K E + + +V EL T+DL+G++ E V +
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 266 AHGREEA-------SDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLE-KQTRELQ- 316
A + +++LQ+ + +L+ +L T +L EN L+ K T+ L
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Query: 317 --AKCNELEN 324
A+ NE++N
Sbjct: 1348 KWAEDNEVQN 1357
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 105 bits (261), Expect = 2e-22
Identities = 135/639 (21%), Positives = 285/639 (44%), Gaps = 92/639 (14%)
Query: 79 KQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQ 138
++ E++ LE+VI E E+L ++LK+ +E +E + + D+ L++Q +
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIE-----NQEELRLLGDE-----LKKQQE 1099
Query: 139 LANQEKTQAVELWQTVSQELDRLHKLY-------------QEHMTEAQIHVFESQKQKDQ 185
+ QEK A++ +S+ DRL ++ Q+ + Q + E QK+ ++
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 186 LFDFQQLTKQLHVTNENMEVT----------NQQFLKTVTEQSVIIEQLRKKLRQAKLEL 235
+ + + K +T E+ME N + +K++T++ ++++L+K + L
Sbjct: 1160 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
Query: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVT- 294
R + ++E G K+E + H +E + +L+ S+ + ++ T
Sbjct: 1220 RGYIREIEAT--------GLQTKEELKIAHIHLKEH--QETIDELRRSVSEKTAQIINTQ 1269
Query: 295 --------IQEANQLRTENTHL---EKQTRELQAKCNELENERYEAIVRARNSMQLLEEA 343
+QE + E L K+ E Q NELE ++ + ++ +E
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 344 NLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR---TKKEVANTKKQCNIQISRLTEE 400
L+ ++ E +++ + + K ++ + + ++ K+ + T + IQ S+ +E
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK--IQESQSKQE 1387
Query: 401 LSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSK 460
S E + +I +++ K + L +I E G ++L+E H + K
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS---KRLQESHDEMKSVAKEK 1444
Query: 461 DDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQEN 520
DDLQ ++ QL+ + E ++++ E ++L+ +E ++E R+ L ++
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 521 KQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQ-----------LREMEDS 569
++ + L I + Q K + +I E +F+IK+ EVQ R+ +DS
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQ-EIYEKEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDS 1562
Query: 570 NRNSI----VELRHLLATQQKAAN---RWKEETKKLTESAEIRINNLKSELSRQKLHTQE 622
SI +EL + L Q+ + KEE K++ E+ +I + LK +T+E
Sbjct: 1563 ALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE-------NTKE 1615
Query: 623 LLSQLEMANEKVAENEKL--ILEHQEKANRLQRRLSQAE 659
++++++ + EK + K+ + E QEK ++ Q E
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Score = 97.4 bits (241), Expect = 4e-20
Identities = 141/649 (21%), Positives = 276/649 (42%), Gaps = 79/649 (12%)
Query: 80 QVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQL 139
++ +++ +L ++ENE L E+ + +L++ P +++ + +++ E+L +
Sbjct: 721 KITDLQKELNKEVEENEALREEV--ILLSELKSLP------SEVERLRKEIQDKSEELHI 772
Query: 140 ANQEKTQAVELWQTVSQELDRLHKLYQE-HMTEAQIHVFESQ-KQKDQLF--------DF 189
EK + L+ V + R+ L +E T+ + +S K DQ F DF
Sbjct: 773 ITSEKDK---LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 190 QQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVT 249
+Q K + NE M K + + L+ +L EL+ +V+E N
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889
Query: 250 EDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLE 309
E L+ Q++ ++ + + + +LQQ +K L QE + L+ L+
Sbjct: 890 EQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL-------TQEKDDLKQLQESLQ 942
Query: 310 KQTRELQAKCNELENERYEAIVRARNSMQLL----EEANLQKSQALLEEKQKEEDIEKMK 365
+ +L++ ++ N + + RN+++ L E N KS+ E + E
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002
Query: 366 ETVSRFVQDATIRTKKEVANTKKQCNI-------QISRLTEELSALQMECAEKQGQIERV 418
ET F Q KK+ K + +I ++ +L E E Q +E V
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062
Query: 419 IKEKKAVEEELEKIYREGRGNESDYRKL--EEMHQRFLVSERSKDDLQL--RLTRAENRI 474
I EK+ ++ +L++ N+ + R L E Q+ +V++ ++ L+R +R+
Sbjct: 1063 IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL 1122
Query: 475 KQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSE-QRLKLQQENKQL---RKETESL 530
++E E+ + QE Q+L NV E E ++E + LK + +NK+L ETE L
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 531 RKIALEAQKKAKVKISTMEHEFSIKE--RGFEVQ-------LREMEDSNRNSIVELR--- 578
+ +VK T E + +KE + FE + +RE+E + + EL+
Sbjct: 1183 ELAQKLNENYEEVKSITKERKV-LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 579 -HLLATQQ---KAANRWKEETKKLTESAEIRINNLKSELSRQKLH--------------T 620
HL Q+ + E+T ++ + ++ ++ K + LH T
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 621 QELLSQLEMANEKVAENEKLILEHQEKAN-RLQRRLSQAEERAASASQQ 668
QE +++LE+ E+ + L E RL + +++E S +++
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Score = 92.4 bits (228), Expect = 1e-18
Identities = 133/687 (19%), Positives = 301/687 (43%), Gaps = 92/687 (13%)
Query: 46 FENLVFDQSFLAPLVTEYDKHLGELNG-----QLKYYQKQVGEMKL-----QLENVIKEN 95
++NLV D L E + L E N L+ K+ EM+L L+N++K
Sbjct: 507 YDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA 566
Query: 96 ERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVS 155
E + +L++ + K+E + ++ ++ LQE + + +K + +++ + S
Sbjct: 567 EVYNQDLENELSSKVEL----------LREKEDQIKKLQEYI---DSQKLENIKMDLSYS 613
Query: 156 QELDRLHKLYQEHMTEAQIHVFESQKQ----KDQLFDFQQLTKQLHVTNENMEVTNQQFL 211
E K ++ + +A+ +++++ + + + ++ K+L T + ME Q +
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQ 673
Query: 212 KTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREE 271
+ + + L K+L+ A E+T +T + G K KD++ E
Sbjct: 674 SQLEAKKKMQVDLEKELQSA----------FNEITKLTSLIDG---KVPKDLLCNLELEG 720
Query: 272 ASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNEL------ENE 325
++L +++ E L + ++L++ + +E+ +E+Q K EL +++
Sbjct: 721 KITDLQKELNKEVEENEA-LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK 779
Query: 326 RYEAIVRARNSMQ-LLEEANLQKSQALLEE---KQKEEDIEKMK------ETVSRFVQDA 375
+ +V + +Q LLEE K + K +++ + K E + V +
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839
Query: 376 TIRTKKEVANTKKQC---NIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK- 431
R +E+ N K+ + + L ELS E EK +++ + E + ++E+LE
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899
Query: 432 ---IYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRY 488
+ R KL++ + + KDDL+ + QL++D + ++
Sbjct: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMN 959
Query: 489 QEMIQKLQNVLESERENCGLVSEQRLKLQQE-NKQLRKETESLRKIALEAQKKAKVKIST 547
+ ++L+N LES +++ ++ + K+ +E ++ L E + E + + + K+
Sbjct: 960 IDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG-----ETKDEFQQKMVG 1014
Query: 548 MEHEFSIKERGFEVQLREMEDSNRNSIVEL-RHLLATQQKAANRWKEETKKLTESAEIRI 606
++ + ++ + + +++D N I+E R + + Q+ K E +++ ES
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKD---NEIIEQQRKIFSLIQE-----KNELQQMLESVIAEK 1066
Query: 607 NNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKA-------NRLQRRLSQAE 659
LK++L T E +L + +++ + ++++ + + A +R RL++ E
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 660 ERAASASQQLSVITVQRRKAASLMNLE 686
E+ SQQL + K L+N++
Sbjct: 1127 EKLKEKSQQL------QEKQQQLLNVQ 1147
Score = 89.7 bits (221), Expect = 8e-18
Identities = 129/587 (21%), Positives = 250/587 (42%), Gaps = 91/587 (15%)
Query: 73 QLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
++++ ++Q KL LEN+ EN RL L + +E+ T+ D+ + +ET++
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV----TKERDDLRSVEETLKV 1700
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
++QL+ L +T++++L++ +L HM H+ E Q+ D+L
Sbjct: 1701 ERDQLK---------ENLRETITRDLEKQEELKIVHM-----HLKEHQETIDKLRGI--- 1743
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
V+ + E++N Q K + + ++ K+++ ELR+A ++E + L
Sbjct: 1744 -----VSEKTNEISNMQ--KDLEHSNDALKAQDLKIQE---ELRIAHMHLKEQQETIDKL 1793
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
+G + +K +L +Q ++ +L IQE + L+K
Sbjct: 1794 RGIVSEKTD--------------KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 313 RELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFV 372
E Q K +E+E + + I ++ LE NL +Q L E ++ + + K ++ + R
Sbjct: 1840 NETQKKVSEMEQLK-KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR-- 1896
Query: 373 QDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKI 432
V T K Q+ +E A +E ++ + KE K ++L +
Sbjct: 1897 ----------VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK 1946
Query: 433 YREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMI 492
E SD +K ++SKD+LQ ++ + + QL E+++ + I
Sbjct: 1947 ISEKTIQISDIQK---------DLDKSKDELQKKIQELQKKELQL-LRVKEDVNMSHKKI 1996
Query: 493 QKLQNVLES-ERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHE 551
+++ + + E +N + S R+ Q K+L + E +R +A E + ++K S
Sbjct: 1997 NEMEQLKKQFEAQNLSMQS-VRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES----- 2050
Query: 552 FSIKERGFEVQLREM--EDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNL 609
++ F LREM D + + + LL+ Q + LTES + + +
Sbjct: 2051 LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ----------QHLTESLREKCSRI 2100
Query: 610 KSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS 656
K L R E+ E N + EK I +E + R++ LS
Sbjct: 2101 KELLKRY----SEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLS 2143
Score = 87.0 bits (214), Expect = 5e-17
Identities = 159/705 (22%), Positives = 301/705 (42%), Gaps = 115/705 (16%)
Query: 66 HLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAV---EKKLEAFPLGTEVGT- 121
HL E + ++ V E Q+ N ++ E+ H++L++ + ++ E P EV
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINT-QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 122 -------DIYADDETVRN-------------LQEQLQLANQE---KTQAVELWQTVSQEL 158
++ + T ++ L E+ Q + +E T+ + +T+ + L
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361
Query: 159 DRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQS 218
+ H +EH+ E + ESQ +++Q + ++ + ME + +
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKD-SALLRIE 1420
Query: 219 VIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQG---QMKKKEKDVVSAHGREEASDR 275
+ + L K+L+++ E++ + ++L + E LQ Q+K+ K++V+ H E +
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480
Query: 276 R----LQQLQSSIKQLEIRLCVTIQEAN----QLRTENTHLE---------------KQT 312
L++ + +I +L + L E + QL N L+ KQ
Sbjct: 1481 VAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540
Query: 313 RELQAKCNELEN--ERYEAIVRARNSMQ--LLEEAN-LQKSQALLEE--KQKEE------ 359
E+Q K NEL+ E +A A S++ +LE N LQ+SQ ++ K+KEE
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 360 ----DIEKMKETVSRFVQDATIRTKKEVANTK---------KQCNIQISRLTEELSALQM 406
+ +++KE V +KE K K C I+ + E L +
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 407 ECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLR 466
E E + I+ + + E LE++ R D R +EE + + ++ K++L+
Sbjct: 1661 ENIETEN-----IRLTQILHENLEEM-RSVTKERDDLRSVEETLK--VERDQLKENLRET 1712
Query: 467 LTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKE 526
+TR + ++L+ + +QE I KL+ ++ SE+ N +S + L+ N L+ +
Sbjct: 1713 ITRDLEKQEELKI-VHMHLKEHQETIDKLRGIV-SEKTN--EISNMQKDLEHSNDALKAQ 1768
Query: 527 TESLR---KIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSN---RNSIVELR-- 578
++ +IA K+ + I + S K +++E+SN + I EL+
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
Query: 579 -HLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAEN 637
H L T +K N E KK++E + LK ++ Q L LS+LE+ N +A+
Sbjct: 1829 EHQLITLKKDVN---ETQKKVSE-----MEQLKKQIKDQSL----TLSKLEIENLNLAQK 1876
Query: 638 EKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASL 682
LE + + + L + EE QL ++Q KA L
Sbjct: 1877 LHENLEEMKSVMKERDNLRRVEETLKLERDQLKE-SLQETKARDL 1920
Score = 81.6 bits (200), Expect = 2e-15
Identities = 166/727 (22%), Positives = 298/727 (40%), Gaps = 155/727 (21%)
Query: 43 DDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSEL 102
D+T L F + T Y + LK Y+K++ ++K QLE V E R +
Sbjct: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLET-RAQAME 372
Query: 103 KDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLH 162
KD + + LE L +V +E + NL L ++ T+ QEL
Sbjct: 373 KDQLAQLLEEKDLLQKV------QNEKIENLTRMLVTSSS---------LTLQQELKAKR 417
Query: 163 KLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENM--EV------TNQQFLKTV 214
K + +I+ ++ DQ +T + H + N+ E+ + F T+
Sbjct: 418 K-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476
Query: 215 TEQSVI----------IEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKK-EKDV 263
S I E + +L + + V E+L E+++ ++K+K + D
Sbjct: 477 DTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDE 536
Query: 264 VSAHGREEASDRRLQ------QLQSSIKQLEI-----------RLCVTIQEANQLRTENT 306
A R+ D+ +Q L++ +K E+ ++ + ++ +Q++
Sbjct: 537 FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQE 596
Query: 307 HLEKQTRE-----------------------LQAKCNELENERYEAIVRARNSMQLLE-- 341
+++ Q E A+ L+ +R A +R+ N ++L E
Sbjct: 597 YIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN-LELKEKM 655
Query: 342 ----------EANLQKSQALLEEKQK-EEDIEKMKETVSRFVQDATIRTKKEVANTKKQC 390
E ++Q Q+ LE K+K + D+EK ++ + T +V C
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK-DLLC 714
Query: 391 NIQI-SRLTEELSALQMECAEKQGQIERVI--KEKKAVEEELEKIYREGRGNESDYRKLE 447
N+++ ++T+ L E E + E VI E K++ E+E++ +E + K E
Sbjct: 715 NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD------KSE 768
Query: 448 EMHQRFLVSERSKDDLQLRLTRAENRIKQL-------ETDSSEEISRYQEMIQKLQNVLE 500
E+H + SE KD L + E+R++ L + D + S Y+ Q+ QN
Sbjct: 769 ELH--IITSE--KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF-- 822
Query: 501 SERENCGLVSEQRLKL-QQENKQLRKETESLRKIALEAQK------KAKVKISTMEHEFS 553
+ + EQ+ K+ +EN+++ +E +L K EAQK K ++S E
Sbjct: 823 ---KTLHMDFEQKYKMVLEENERMNQEIVNLSK---EAQKFDSSLGALKTELSYKTQELQ 876
Query: 554 IKERGFEVQLREMED-----SNRNS---IVELRHLLATQQ--------KAANRWKEETKK 597
K R + +L EME NR+S VE L T++ K + K++ K+
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 598 LTESAEIRINNLKSELS---RQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRR 654
L ES +I + LKS++ + TQE QL A E + +HQE N L+ +
Sbjct: 937 LQESLQIERDQLKSDIHDTVNMNIDTQE---QLRNALES-------LKQHQETINTLKSK 986
Query: 655 LSQAEER 661
+S+ R
Sbjct: 987 ISEEVSR 993
Score = 41.6 bits (96), Expect = 0.002
Identities = 109/663 (16%), Positives = 258/663 (38%), Gaps = 122/663 (18%)
Query: 56 LAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDA--VEKKLEAF 113
++ + + DK EL +++ QK+ +LQL V ++ H ++ + ++K+ EA
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKK----ELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009
Query: 114 PLGTE-VGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRL----------- 161
L + V D + + + E++++ +E+ + + +++ E D+
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
Query: 162 ---HKLYQEH--MTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTE 216
H++ E +++ Q H+ ES ++K ++L K+ +++ E N+ L E
Sbjct: 2070 RQNHQVKPEKRLLSDGQQHLTESLREKCSRI--KELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 217 --------------------QSVIIEQLRKKLRQAKLELRVAVAKVEEL----TNVTEDL 252
Q+ IE+L ++ +E + K++ + T + E+
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSS-------IKQLEIRLCVTIQ--------- 296
+ K E D + +++ ++Q LQ ++ L++ + +
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFS 2247
Query: 297 --EANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQ---------------- 338
E ++TE + +E+ E N R++ I + +N +Q
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD-IEKLKNGIQKENDRICQVNNFFNNR 2306
Query: 339 ---LLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQD---------------ATIRTK 380
++ E+ + ++ K+ E+D++ +KE + ++ T +
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366
Query: 381 KEVANTKKQCNI---QISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGR 437
K T + + +I L L + K+ +I ++ KE + + + K+ +
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426
Query: 438 GNESDYRKLEEMHQ--RFLVSERSK------DDLQLRLTRAENRIKQLETDSSEEISRYQ 489
+ K +E Q + V+ +K +DL+++L + + + + +EIS +
Sbjct: 2427 ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK 2486
Query: 490 EMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETE-SLRKIALEAQKKAKVKISTM 548
++ + V+ REN +R + Q+ + + T+ L + + +T
Sbjct: 2487 ATVEYQKEVIRLLRENL-----RRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTK 2541
Query: 549 EHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANR---WKEETKKLTESAEIR 605
+ E ++ +++ N I + LL+ Q +N WKE T K ++
Sbjct: 2542 ALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVT 2601
Query: 606 INN 608
N
Sbjct: 2602 CEN 2604
Score = 36.6 bits (83), Expect = 0.080
Identities = 87/474 (18%), Positives = 192/474 (40%), Gaps = 60/474 (12%)
Query: 4 EIDFLREQNRRL--NEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVT 61
EI+F +E + R+ N Q + K + + C E + L + S++ +
Sbjct: 2127 EIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQR-CSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E + + + ++ E+ ++++++ ++ + EL+D K + L E
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL--KLNQNMDLHIEEIL 2243
Query: 122 DIYADDE--TVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHK-LYQEHMTEAQIHVF- 177
+++ E +++ +Q+ +E TQ +E W ++++L + +E+ Q++ F
Sbjct: 2244 KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFF 2303
Query: 178 ---------ESQKQKDQLF----DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIE-- 222
ES + +++ +++Q K L NE + N Q LKT +
Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL-FKNYQTLKTSLASGAQVNPT 2362
Query: 223 -QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
Q K ++ K+ EL N + + KE ++ E ++ + +LQ
Sbjct: 2363 TQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQ 2422
Query: 282 SSIKQLEIRLCVTIQEANQLRTENTHL-----EKQTRELQAKCNELENERYE-------- 328
+ + + L T +E Q+ + L +++ +L+ K +++ E+ +
Sbjct: 2423 AKVHESNKCLEKT-KETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE 2481
Query: 329 -----AIVRARNSMQLLEEANLQKSQ-----ALLEEKQKEEDIEK----------MKETV 368
A V + + L NL++SQ +++ E + K ++ T
Sbjct: 2482 ISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTK 2541
Query: 369 SRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEK 422
+ ++ IR +KE++ K+Q I + E LS Q E + ER +K +
Sbjct: 2542 ALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Score = 32.3 bits (72), Expect = 1.5
Identities = 47/286 (16%), Positives = 117/286 (40%), Gaps = 38/286 (13%)
Query: 85 KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEK 144
+L E + + LH + A+ K+ + + E + ++ + LQ ++ +N+
Sbjct: 2377 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKE----LEVTNDIIAKLQAKVHESNKCL 2432
Query: 145 TQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENME 204
+ E Q + ++ K Y+E + + ++ + + +K + + ++ K++ T
Sbjct: 2433 EKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEK--MKNAKEFEKEISATKA--- 2487
Query: 205 VTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVV 264
TV Q +I LR+ LR+++ + ++ + ++E Q K
Sbjct: 2488 --------TVEYQKEVIRLLRENLRRSQ--------QAQDTSVISEHTDPQPSNKPLTCG 2531
Query: 265 SAHGREEASDR--------RLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQ 316
G + + RL++ S +KQ +L I++ N+L + N HL + + +
Sbjct: 2532 GGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL---IKQKNELLSNNQHLSNEVKTWK 2588
Query: 317 AKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIE 362
+ L+ E ++ + + K + + + KE +++
Sbjct: 2589 ER--TLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 104 bits (259), Expect = 3e-22
Identities = 152/698 (21%), Positives = 292/698 (41%), Gaps = 101/698 (14%)
Query: 43 DDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSEL 102
++ E ++ D V + E+ LK ++ + ++ + EN+ K+ + +L
Sbjct: 2167 EENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQL 2226
Query: 103 KDAVEKKLEAFP--LGTEVGTDIYADDET---VRNLQEQLQLANQEKTQAV---ELWQTV 154
+ ++K L +F L + +I +E+ V LQ QL+ N+ E+ +
Sbjct: 2227 SE-LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 155 SQELDRLHKLYQEHMTEAQIHVFESQKQKD---QLFDFQQLTKQLHVTN------ENMEV 205
Q LD + +EH I ++ + D QL QQL + H + EN+E
Sbjct: 2286 EQSLDP--PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER 2343
Query: 206 ------TNQQFLKTVTEQS--------VIIEQLRKKLRQAKLELRVAVAKVEELTN---- 247
TNQ+ E S IE + + LR +L++ ++ E LTN
Sbjct: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK 2403
Query: 248 ----------VTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE 297
+ + +++KE++ V +E S ++ LQ+ +K+L R+ +
Sbjct: 2404 EQERISELEIINSSFENILQEKEQEKVQM---KEKSSTAMEMLQTQLKELNERVAALHND 2460
Query: 298 ANQLRTENTHLEKQTRELQAKCNELENERY-EAIVRARNSMQLLEEANLQKSQALLEEKQ 356
+ + +L Q +C ELE + + + A+N+ +L+ + Q + + KQ
Sbjct: 2461 QEACKAKEQNLSSQV-----ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQ 2515
Query: 357 KEEDIEKMKETVSRFV-----QDATIRTKKEVANTK---KQCNIQISRLTEELS----AL 404
K +EK E +SR Q+ + +V K+ N+++ LT EL L
Sbjct: 2516 K---LEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 2572
Query: 405 QMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQ 464
Q + A Q +E + K +E ELE + S K+ +M + + +LQ
Sbjct: 2573 QSKNASLQDTLEVLQSSYKNLENELELTKMD---KMSFVEKVNKMTAK-------ETELQ 2622
Query: 465 LRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLR 524
+ + +L+ + S E +R +Q L ++S ++ Q +L EN +L+
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD-------QLKELTLENSELK 2675
Query: 525 KETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQ 584
K + + K +E + K + +I+ + E+ + L + I R L ++
Sbjct: 2676 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 585 QKAANRWKEETKKLTESAEIRINNLKS------ELSRQKLHTQELLSQLEMANEKVAENE 638
++ + K E L S E N+LK+ EL + K+ + ++QL+ NE+
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 639 KLILEH----QEKANRLQRRLSQAEERAASASQQLSVI 672
KL+++ +E+ LQ+ LSQ + AA Q+ +
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQ--AAQEKQKTGTV 2831
Score = 95.5 bits (236), Expect = 1e-19
Identities = 152/669 (22%), Positives = 286/669 (42%), Gaps = 123/669 (18%)
Query: 78 QKQVGEMKLQLENVIKENERL---HSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQ 134
+K VGE+K + ++ ++ E H EL VE G +++AD + ++
Sbjct: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSE-----GLNSDLEMHADKSSREDIG 1883
Query: 135 EQLQLANQEKTQAVELWQTVSQELDRLH--KLYQEHMT---EAQIHVFESQK---QKDQL 186
+ + N E + V EL R+ K EH EA + V +++K +KD
Sbjct: 1884 DNVAKVNDSWK---ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN- 1939
Query: 187 FDFQQLTKQLHVTNENMEVTNQQF------LKTVTEQSVIIEQLRKKLRQAKLEL----- 235
+ K + E + V + L T+++++ ++QL +K+++ EL
Sbjct: 1940 ---ENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQS 1996
Query: 236 ------RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEI 289
+VA A+V+E T + + L + + KD H +E +LQ L+ + L +
Sbjct: 1997 ECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD--KTHLQE-----KLQSLEKDSQALSL 2049
Query: 290 RLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQ 349
C + QL E L K++ LQA+ +E + E+ N + LE A ++K +
Sbjct: 2050 TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL-------NVSKALEAALVEKGE 2102
Query: 350 ALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECA 409
L +E++ +++ + + +R + E A+ KKQ +I E+L + E
Sbjct: 2103 FALRLSSTQEEVHQLRRGIEK------LRVRIE-ADEKKQLHI-----AEKLKEREREND 2150
Query: 410 EKQGQIERVIKEKKAVEEELEKIYREGRGNESDYR----KLEEMHQRFLVSE-------R 458
+ ++E + +E + EE E + + ++++ ++EEM + V E
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 459 SKDDLQLRLTRAENRIKQL-----------------ETDSSEEISRYQEMIQ-KLQNVLE 500
K++L ++ + ++ +L E EE EM+Q +L+ + E
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 501 SERENCG-----LVSEQRLKLQ-QENKQLRKETESLRKIALEAQKKAKV----KISTMEH 550
+ CG +EQ L +E QLR E LR LEA +K ++ ++ EH
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR-ARLEADEKKQLCVLQQLKESEH 2329
Query: 551 EFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKA-ANRWKEETKKLTESAE------ 603
+ + E RE+E + N E L A K K + + +T+S
Sbjct: 2330 HADLLKGRVENLERELEIARTNQ--EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387
Query: 604 IRINNLKSELSRQKLHTQELLSQLEMANEK----VAENEKLILEHQEKAN----RLQRRL 655
+ I + K L+ + QE +S+LE+ N + E E+ ++ +EK++ LQ +L
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
Query: 656 SQAEERAAS 664
+ ER A+
Sbjct: 2448 KELNERVAA 2456
Score = 94.7 bits (234), Expect = 2e-19
Identities = 152/751 (20%), Positives = 318/751 (42%), Gaps = 108/751 (14%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLV 60
+ ++D L+++ ++ R++Q++S QK + E + NL + L +
Sbjct: 23 LEGQLDKLKKEKQQ-----RQFQLDSLEAALQKQKQKVENEKTEG-TNLKRENQRLMEIC 76
Query: 61 TEYDKHLGELNGQLKYYQKQV----GEM---KLQLENVIKENERLHSELKDAVE------ 107
+K +++ +L+ + QV G++ K Q+E + +E +R SEL+ + +
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 108 ---------KKLEAFPL--GTEVGTDIYAD--DETVRNLQEQLQLANQEKT-QAVELWQT 153
+K+ PL Y D ++ + ++E+ +L + K QA + QT
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 154 VSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLF----------DF--------QQLTKQ 195
+ Q H+ H + + ++ +K L DF Q++T
Sbjct: 197 LPQATMN-HRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPS 255
Query: 196 LHVTNENMEVTNQQFLKTVTEQSVI------IEQLRKKLRQAKLELRVAVAKVEELTNVT 249
N F + ++ ++LR K+ + +L L+ +++ N
Sbjct: 256 RSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKF 315
Query: 250 EDLQGQMKKK-----EKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTE 304
++LQ Q++K EK+ V R+E Q Q+S K +++ + TE
Sbjct: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY------TALEQKLKKLTE 369
Query: 305 NTHLEKQTRE-----LQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEE 359
+ ++Q E L+ K E E E E + R + S Q L++ +Q L +E Q+ +
Sbjct: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAK 429
Query: 360 DIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVI 419
++ V + D K+++ N ++ ++ R + A Q++ E + +E +
Sbjct: 430 NM----HNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMK 485
Query: 420 KEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQL-E 478
KE ++ E+ RE E++ + +++ + S+ ++++ + T E ++ L E
Sbjct: 486 KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ---SQNFAEEMKAKNTSQETMLRDLQE 542
Query: 479 TDSSEEISRYQEMIQKLQNVLESERE-NCGLVSEQRLKLQQENKQLRKETESLRKI--AL 535
+ +E S E ++ LE +R+ + L+ ++ ++Q N +L K + + + AL
Sbjct: 543 KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 536 EAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHL---LATQQKAANRWK 592
E +KK ++ + FS + E L +ME N ++ HL L TQQ ++ +
Sbjct: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
Query: 593 EETKKL---TESAEIRINNLKS-------ELSRQKLHTQELLSQLEMANEKVAENEKLIL 642
E + L E+ + I NL + E+ QKL EL + E +++K
Sbjct: 663 ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK--------- 713
Query: 643 EHQEKANRLQRRLSQAEERAASASQQLSVIT 673
HQ++ + + SQ + +L +++
Sbjct: 714 -HQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Score = 87.4 bits (215), Expect = 4e-17
Identities = 139/656 (21%), Positives = 285/656 (43%), Gaps = 79/656 (12%)
Query: 66 HLGELNGQLKYYQKQVGEMKLQLENV---IKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
H E+ GQ+ +Q E++LQLE + E E++ ++ +D + + + + T
Sbjct: 304 HEKEMKGQVNKFQ----ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD---QASTK 356
Query: 123 IYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQ 182
A ++ ++ L E L Q A ++ Q++ K +QE ++ Q F++ Q
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESAR---CSLEQKIKEKEKEFQEELSRQQ-RSFQTLDQ 412
Query: 183 -----KDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV 237
K +L Q K +H + E+ +K E + +E+ ++KL +A+ +
Sbjct: 413 ECIQMKARLTQELQQAKNMHNVLQ-AELDKLTSVKQQLENN--LEEFKQKLCRAEQAFQA 469
Query: 238 AVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE 297
+ K EL E++ KKE +++ +H ++A R + L++ +K ++ L +
Sbjct: 470 SQIKENELRRSMEEM-----KKENNLLKSHSEQKA--REVCHLEAELKNIKQCLNQSQNF 522
Query: 298 ANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQK 357
A +++ +NT E R+LQ K N+ EN + + + ++ LE+ SQ LL K++
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSL--TLEKLKLAVADLEKQR-DCSQDLL--KKR 577
Query: 358 EEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIER 417
E IE++ + +S+ T + K + + + + L EE + +E + + +
Sbjct: 578 EHHIEQLNDKLSK-----TEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632
Query: 418 VIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQL 477
+ EK+ ++ KI ++ K E ++R E +++L + + N +
Sbjct: 633 MESEKENLQ---SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSK 689
Query: 478 ETDSSEEISRYQEMIQK-----------LQNVLESERENCGLVSEQRLKLQQENKQ---- 522
+ + Y E+ QK ++N+ + G V + KLQ + +
Sbjct: 690 SVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDK 749
Query: 523 ------LRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVE 576
L E ESLR + + K ++ +H+ S+ F+ Q M S N I E
Sbjct: 750 DRCYQDLHAEYESLRDL---LKSKDASLVTNEDHQRSL--LAFD-QQPAMHHSFANIIGE 803
Query: 577 LRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAE 636
+ + +++ +++ K + + R+++L+ L QK +L Q E + E
Sbjct: 804 -QGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 637 NEKLILE----HQEKANRLQRRLSQAEERAASASQQLSVITV----QRRKAASLMN 684
E+ +++ HQ +R+S+ +E SA Q + T+ + K L+N
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQE-DTSAHQNVVAETLSALENKEKELQLLN 917
Score = 79.3 bits (194), Expect = 1e-14
Identities = 127/665 (19%), Positives = 277/665 (41%), Gaps = 68/665 (10%)
Query: 31 SSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLEN 90
+S++K + E D+ + V Q + E + H L G+++ ++++ + E+
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQ------LKESEHHADLLKGRVENLERELEIARTNQEH 2354
Query: 91 VIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVEL 150
E E E+ + ++ K+E T+ + D T+R+ +E L Q++ + +
Sbjct: 2355 AALEAENSKGEV-ETLKAKIEGM---TQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410
Query: 151 WQTVSQELDR-LHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQ 209
+ ++ + L + QE + + + + QL + + LH E + Q
Sbjct: 2411 LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470
Query: 210 FLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGR 269
V + QL + L +AK V + V L ED + +++KK++++ +
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 270 EEASDRRLQQLQS--------SIKQLEIR-LCVTIQEANQ-LRTENTHLEKQTRELQAKC 319
+ ++ + +L + LE+R L V +++ Q L+++N L+ LQ+
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY 2590
Query: 320 NELENERY------EAIVRARNSMQLLEEANLQKSQALLEEKQKE--EDIEKMKETVSRF 371
LENE + V N M +E LQ+ + +K E E++ K ++
Sbjct: 2591 KNLENELELTKMDKMSFVEKVNKMTA-KETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 372 VQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK 431
+Q + K + K+ ++ S L + L + + EK+G++ I E + E EK
Sbjct: 2650 LQ-LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
Query: 432 ------------------IYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLT-RAEN 472
YRE ++ + +++ L S + + + L+ T +
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768
Query: 473 RIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRK 532
+K+ + D+ + +++ ++ ++ Q ++ ++C + E++ LQ+E QL+
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ-------- 2820
Query: 533 IALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWK 592
A + ++K + T E + + + + L E + + LL + +K
Sbjct: 2821 -AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEK------ 2873
Query: 593 EETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV-AENEKLILEHQEKANRL 651
+K E E ++ +L S+ S+Q LL + + + EK + Q KA+
Sbjct: 2874 --LEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGK 2931
Query: 652 QRRLS 656
++R S
Sbjct: 2932 RQRSS 2936
Score = 64.7 bits (156), Expect = 3e-10
Identities = 128/646 (19%), Positives = 257/646 (39%), Gaps = 88/646 (13%)
Query: 87 QLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT------DIYADDETVRNL---QEQL 137
++EN+ + +L +++D +E KL+ L E+ D++A+ E++R+L ++
Sbjct: 717 EIENMCLKTSQLTGQVED-LEHKLQL--LSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
Query: 138 QLANQEKTQAVELWQTVSQELDRLHKLYQEH------MTEAQIHVFESQKQKDQLFDFQQ 191
+ N++ +++ + + E +E ++ +S K L Q
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL---QN 830
Query: 192 LTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAK-------LELRVAVAKVEE 244
L + E+ + N K E I ++ + L +A+ E ++K++E
Sbjct: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890
Query: 245 LT----NVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
T NV + ++ KEK++ + + E +Q+L+ S LE L + Q
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL-----KELQ 945
Query: 301 LRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED 360
L +E LEK+ N+ E I L+E N +Q + QK E
Sbjct: 946 LLSETLSLEKKEMSSIISLNKRE------IEELTQENGTLKEINASLNQEKMNLIQKSES 999
Query: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK 420
+ + + + + + K+E ++C + E+LS EK ++E ++
Sbjct: 1000 FANYIDEREKSISELSDQYKQEKLILLQRCE-ETGNAYEDLSQKYKAAQEKNSKLECLLN 1058
Query: 421 EKKAVEEELEKIYREGRGNESDYRK--LEEMHQRFLV----SERSKDDLQLRLTRAENRI 474
E ++ E R NE + K + HQ FL +E +L L L + +
Sbjct: 1059 ECTSL--------CENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQAL 1110
Query: 475 KQLETDS-----SEEISRYQEM--IQKLQNVLESERENCGLVSEQRLKLQQENKQLRK-E 526
+ TD+ SE QE+ +++ QN ++ E + +EQ +K+ + + + E
Sbjct: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKE---RGFEVQLREMEDSNRNSIVELRHLLAT 583
+E +R E + + + + +KE + QL ++E RN ++L+
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKE 1230
Query: 584 QQKAAN-----RWKEETKKLTESAEIRINNLKS--------------ELSRQKLHTQELL 624
++ + R ET L + I+ LK ELS + L
Sbjct: 1231 KECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQ 1290
Query: 625 SQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLS 670
L+ K+ E EK+ Q + L L+ + +A+++++
Sbjct: 1291 CSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Score = 60.5 bits (145), Expect = 5e-09
Identities = 115/590 (19%), Positives = 231/590 (39%), Gaps = 93/590 (15%)
Query: 145 TQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENME 204
T+A++ Q + +LD+L K Q+ + QKQK + V NE E
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQK------------VENEKTE 61
Query: 205 VTNQQFLKTVTEQSV-IIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDV 263
TN LK ++ + I E L K ++ EL+V ++V + Q++K E+++
Sbjct: 62 GTN---LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL 118
Query: 264 VSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE--ANQLRTENTHLEKQTRELQAKCNE 321
E S + Q S+ C T Q+ L + + +L+ K N+
Sbjct: 119 KRCKSELERSQQAAQSADVSLNP-----CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK 173
Query: 322 --LENERYEAIVR---ARNSMQLLEEANL-------------------QKSQALLEEKQK 357
E +R EA V+ A+ + Q L +A + +K+ + L +
Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233
Query: 358 EEDIEK----------MKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQME 407
I + + T SR +T++ K AN+ N L ++L A E
Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSR----STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQE 289
Query: 408 CAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRL 467
K ++E L+ +E +G + +++L+ ++ V K+ + L
Sbjct: 290 LRNKINELEL----------RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKV---L 336
Query: 468 TRAENRIKQLETDSSEEISRYQEMIQKLQNVLES---ERENCGLVSEQRLKLQQENKQLR 524
+ + + + + ++Y + QKL+ + E +R+N R L+Q+ K+
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN---AESARCSLEQKIKEKE 393
Query: 525 KETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQ 584
KE + E + + T++ E + +L++ ++ + EL L + +
Sbjct: 394 KEFQ-------EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK 446
Query: 585 QKAANRWKEETKKLT------ESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENE 638
Q+ N +E +KL ++++I+ N L+ + K L S E +V E
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 639 KLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLENI 688
+ ++ N+ Q + + + S L + + + + + LE +
Sbjct: 507 AELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Score = 60.5 bits (145), Expect = 5e-09
Identities = 139/746 (18%), Positives = 290/746 (38%), Gaps = 95/746 (12%)
Query: 3 AEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE 62
AEI L++ N L + + Q+ S E L ++ ++ +++
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLS--------------------ETLSLEKKEMSSIISL 964
Query: 63 YDKHLGEL---NGQLKYYQKQVGEMKLQL-------ENVIKENERLHSELKDAV-EKKLE 111
+ + EL NG LK + + K+ L N I E E+ SEL D ++KL
Sbjct: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLI 1024
Query: 112 AFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLH----KLYQE 167
E G + + QE+ + L + EL++L K +QE
Sbjct: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084
Query: 168 HMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVT-----NQQFLKTVTEQSVIIE 222
+T+ +Q +L QQ + N+N + Q+ + EQ+ + +
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQS 282
++ L++ + ++V K E +E ++ +K++E + R + + + L+
Sbjct: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE------RNQCNFKPQMDLEV 1198
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
L+ +Q LR + L++ +E + +EL+ R + MQ E
Sbjct: 1199 KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEI 1258
Query: 343 ANLQKSQALLEEKQKEEDIE-KMKETVSRFVQDATIRTKKEVANTKKQCNI---QISRLT 398
+ L+ + EEK E + + +Q + T ++ +K C I + L
Sbjct: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
Query: 399 EELSALQMEC----AEKQGQIERVIKEKKAVEEELEKIYRE-----------GRGNESDY 443
EL+ + EC + ++ +++ E K + ++ ++ E + NE
Sbjct: 1319 TELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
Query: 444 RKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQ-----EMIQKLQNV 498
L + + + D ++++ AE + K L S +I Q + +LQ
Sbjct: 1379 VSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTY 1438
Query: 499 LESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERG 558
++S + + L L + + + ++ LE + S + S+ G
Sbjct: 1439 VDS-------LKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLG 1491
Query: 559 ----FEVQLREMED----SNRNSIVELRHLLATQQKAANRWKEE-TKKLTESAEIR-INN 608
+ L + D SN V + ++ +E T+K T SA + +
Sbjct: 1492 DSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE 1551
Query: 609 LKS--ELSRQKLH--TQELLSQLEMANEKVAENEKLILEHQEKANRLQRRL----SQAEE 660
L+S E+ RQ L +++ SQ M N+++ E E+L+ +++ + L+++ Q ++
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
Query: 661 RAASASQQLSVITVQRRKAASLMNLE 686
+ S + ++ +K ++LE
Sbjct: 1612 KLTSVTLEMESKLAAEKKQTEQLSLE 1637
Score = 60.1 bits (144), Expect = 7e-09
Identities = 94/441 (21%), Positives = 181/441 (41%), Gaps = 81/441 (18%)
Query: 271 EASDRRLQQLQSSIKQL-------EIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELE 323
E DR+++ L + +K+L E++L I+ +L L+K+ +L K
Sbjct: 1791 EDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFS 1850
Query: 324 NERYEAIVRARNSMQLLEEANLQKSQALLEE------------KQKEEDIEK-----MKE 366
+ E + R S L + + ++ E+ K++ D+E E
Sbjct: 1851 CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
Query: 367 TVSRFVQDATIRTKKEVANTKKQC------NIQ--ISRLTEELSALQMECAEKQGQIERV 418
S + + EV T+K C N Q I L EELS + E + +G+++ +
Sbjct: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 419 IKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLE 478
K+ A+++ EK+ + + ES + E +H + K+ +L ++ L
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELES--HQSECLHCIQVAEAEVKEKTEL--------LQTLS 2020
Query: 479 TDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQ 538
+D SE + + +KLQ+ LE + + L + +L+ + QL KE E L K
Sbjct: 2021 SDVSELLKDKTHLQEKLQS-LEKDSQALSLT---KCELENQIAQLNKEKELLVK----ES 2072
Query: 539 KKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKL 598
+ + ++S ++E + E L E E L++ Q+ ++ + +KL
Sbjct: 2073 ESLQARLSESDYEKLNVSKALEAALVEKG--------EFALRLSSTQEEVHQLRRGIEKL 2124
Query: 599 TESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQA 658
E +++LH E L + E N+ + ++K L+R L +
Sbjct: 2125 RVRIEAD--------EKKQLHIAEKLKERERENDSL----------KDKVENLERELQMS 2166
Query: 659 EERAASASQQLSVITVQRRKA 679
EE +Q+L ++ + KA
Sbjct: 2167 EE-----NQELVILDAENSKA 2182
Score = 59.7 bits (143), Expect = 9e-09
Identities = 156/740 (21%), Positives = 285/740 (38%), Gaps = 138/740 (18%)
Query: 5 IDFLREQNRRLNEDFRRYQ---------------MESFSKYSSVQKAVCQGEGDDTFENL 49
+D L+ +N L+ + R +Q + S S + GD +F
Sbjct: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498
Query: 50 VFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAV 106
+ +Q+ L L L G + Q V E+ LQ EN+ ++ E A
Sbjct: 1499 LLEQTGDMSL-------LSNLEGAVSANQCSVDEVFCSSLQEENLTRK------ETPSAP 1545
Query: 107 EKKLEAFPLGTEVGTDIYADDETVRNLQEQLQ----LANQEKTQAVELWQTVSQELDRLH 162
K +E E ++Y +++ L+E+++ + N+E + +L + QELD L
Sbjct: 1546 AKGVEEL----ESLCEVYR--QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR 1599
Query: 163 KLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIE 222
K Y + Q Q+LT VT + K E+ E
Sbjct: 1600 KQYLSENEQWQ----------------QKLTS----------VTLEMESKLAAEKKQT-E 1632
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNV-TED-LQGQMKKKEKDVVSAHGREEASDRR---- 276
QL +L A+L+L+ L + TED +QG + E +S E ++R
Sbjct: 1633 QLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQG---RNESCDISKEHTSETTERTPKHD 1689
Query: 277 LQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNS 336
+ Q+ Q ++ L + + T K T E + + N + + S
Sbjct: 1690 VHQICDKDAQQDLNLDIE-------KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
Query: 337 MQLLEEANLQKSQAL--LEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQI 394
+ + E + AL ++ +EDI ++ V + +R + + ++ +
Sbjct: 1743 SECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKE-TSNENLRLLHVIEDRDRKVESLL 1801
Query: 395 SRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDY-RKLE------ 447
+ + E S L ++ + +IE I ELEKI E + SD KLE
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACI--------ELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 448 -EMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENC 506
E+ QR SE DL++ ++ + + + ++ ++E ++N L R
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVENELSRIRSEK 1911
Query: 507 GLVSEQRLKL-------QQENKQLRKETESLRKIALEAQKKAKVKISTMEH------EFS 553
+ + L L Q E L K+ E+ +K+ + +++ V S S
Sbjct: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971
Query: 554 IKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKL-TESAEIRINNLKSE 612
K + +M++ + L Q A KE+T+ L T S+++ SE
Sbjct: 1972 KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV------SE 2025
Query: 613 LSRQKLHTQELLSQLEMANEKVAENEKLILEHQ------------EKANRLQRRLSQAEE 660
L + K H QE L LE ++ ++ K LE+Q +++ LQ RLS+++
Sbjct: 2026 LLKDKTHLQEKLQSLEKDSQALSLT-KCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 661 RAASASQQLSVITVQRRKAA 680
+ S+ L V++ + A
Sbjct: 2085 EKLNVSKALEAALVEKGEFA 2104
Score = 30.8 bits (68), Expect = 4.4
Identities = 24/127 (18%), Positives = 55/127 (43%)
Query: 411 KQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRA 470
K+G R +++ + +E +L+K+ +E + + LE Q+ ++ L R
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE 68
Query: 471 ENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESL 530
R+ ++ + + +Q ++ + + +Q KL+QE K+ + E E
Sbjct: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 531 RKIALEA 537
++ A A
Sbjct: 129 QQAAQSA 135
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 103 bits (258), Expect = 4e-22
Identities = 137/695 (19%), Positives = 310/695 (44%), Gaps = 73/695 (10%)
Query: 47 ENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAV 106
E + S +A E ++ L E N +++ + + ++ ++ +++H E +
Sbjct: 707 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEM 766
Query: 107 EKKLEAFPLGTEVGTDIYADDETVRNLQEQ----------------------LQLANQEK 144
EK++E E + + E ++ +Q ++ N +K
Sbjct: 767 EKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKK 826
Query: 145 TQAVELWQT-VSQE------LDRLHKLYQEHMT------EAQIHVFESQ--KQKDQLFDF 189
+A++ Q VS+E LD ++ +E + E FE Q K+ ++++
Sbjct: 827 DEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCL 886
Query: 190 QQLTKQLHVTNENMEVTNQQ---FLKTVTEQSVIIEQ---LRKKLRQAKLELRVAVAKVE 243
Q K+L + N +++ T++Q T+ +Q +++Q +L + +L V+K+E
Sbjct: 887 Q---KELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 244 -ELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLR 302
EL E +++K E+ SA + +++ +L + +Q++I + +E +++
Sbjct: 944 QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003
Query: 303 TENTHLEKQTRELQAKCNELE---NERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEE 359
E HL++ ++L+ ++ + + N+++ LE+ L E QK E
Sbjct: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
Query: 360 DIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVI 419
+E + ++ +T+R +E+ + ++ + + + L E E + +IE
Sbjct: 1064 VLETELQNAHGELK-STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE--- 1119
Query: 420 KEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLET 479
+KK E+++ +E R E R + H + E + +++ ++ + E +++ E
Sbjct: 1120 -DKKQELLEMDQALKE-RNWELKQRAAQVTHLDMTIREH-RGEMEQKIIKLEGTLEKSEL 1176
Query: 480 DSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETE--SLRKIALEA 537
+ E + + + KLQN E RE ++ L+ +QE QL+KE E R +E+
Sbjct: 1177 ELKECNKQIESLNDKLQNAKEQLREKEFIM----LQNEQEISQLKKEIERTQQRMKEMES 1232
Query: 538 QKKAKVKISTMEHEFSIKERGFEVQL-REMEDSNRNSIVELRHLLATQQKAANRWK---E 593
K + + +++ +I + G E++L RE ++ + E RH Q+ R E
Sbjct: 1233 VMKEQEQYIATQYKEAI-DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELE 1291
Query: 594 ETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILE--HQEKANRL 651
+ K+L++ + N+L EL K+ L ++++ +K++ + + E H E +
Sbjct: 1292 DMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME---MI 1348
Query: 652 QRRLSQAEERAASASQQLSVITVQRRKAASLMNLE 686
+ + A+ + ++ SQ+ SV + + + + LE
Sbjct: 1349 SHQENHAKWKISADSQKSSVQQLNEQLEKAKLELE 1383
Score = 87.4 bits (215), Expect = 4e-17
Identities = 109/513 (21%), Positives = 215/513 (41%), Gaps = 70/513 (13%)
Query: 198 VTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMK 257
V ++N N+Q+ K IE+LR KL Q + E + T+ + +Q ++
Sbjct: 620 VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL 679
Query: 258 KKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQA 317
+K + + E ++ QL + KQLE ++ + + +N LE++ E
Sbjct: 680 EKASN---SSKLESEMTKKCSQLLTLEKQLEEKIVAY----SSIAAKNAELEQELMEKNE 732
Query: 318 KCNELE---NERYEAIVRARNSMQLLE-------EANLQKSQALLEEKQKEEDIEKMKET 367
K LE N +E I A + + E +++ +A LE+K ++ ++ ++T
Sbjct: 733 KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK--DQQFKEQEKT 790
Query: 368 VSRFVQDATIRTK------KEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKE 421
+S QD + + + +K + + + E L ALQ + +E+ ++ ++
Sbjct: 791 MSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA 850
Query: 422 KKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLET-D 480
+ +EEL + GN+ + K + K ++ + E +IK +
Sbjct: 851 LEICKEELVLHLNQLEGNKEKFEK-----------QLKKKSEEVYCLQKELKIKNHSLQE 899
Query: 481 SSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK 540
+SE+ Q +Q+ Q +L+ E G + + + KL+++ +L +E + R+ + E +K
Sbjct: 900 TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK 959
Query: 541 AKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTE 600
+ K + HE +K R ++EL + +++KEE K+
Sbjct: 960 MEEKCESAAHEADLK---------------RQKVIELTGTARQVKIEMDQYKEELSKM-- 1002
Query: 601 SAEIRINNLKSELSRQKLHTQEL-------LSQLEMANEKVAENEKL-------ILEHQE 646
E I +LK + + +H +L ++LE V E EKL + E +
Sbjct: 1003 --EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ 1060
Query: 647 KANRLQRRLSQAEERAASASQQLSVITVQRRKA 679
K L+ L A S +QL + +KA
Sbjct: 1061 KREVLETELQNAHGELKSTLRQLQELRDVLQKA 1093
Score = 76.3 bits (186), Expect = 9e-14
Identities = 78/450 (17%), Positives = 193/450 (42%), Gaps = 35/450 (7%)
Query: 69 ELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDE 128
EL G + + ++ + K +L + KE L + ++ + + + T++
Sbjct: 980 ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTN 1039
Query: 129 TVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFD 188
V+ L++ E T+A++ + + EL H E + + + Q+ +D L
Sbjct: 1040 AVKELEKLQHSTETELTEALQKREVLETELQNAHG-------ELKSTLRQLQELRDVLQK 1092
Query: 189 FQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNV 248
Q ++ + T +++ ++ + ++ + ++ + L++ EL+ A+V L
Sbjct: 1093 AQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMT 1152
Query: 249 TED-----------LQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQE 297
+ L+G ++K E ++ + + E+ + +LQ + +++ E + QE
Sbjct: 1153 IREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQE 1212
Query: 298 ANQLRTENTHLEKQTRELQAKCNELEN---ERYEAIVRARNSMQLLEEANLQKSQALLEE 354
+QL+ E +++ +E+++ E E +Y+ + ++L E L E
Sbjct: 1213 ISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272
Query: 355 KQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQ 414
+ ++ ++ E +S ++D +K++ A+ + L EEL A ++ A + +
Sbjct: 1273 RHQQVQAQREIERLSSELEDMKQLSKEKDAHG--------NHLAEELGASKVREAHLEAR 1324
Query: 415 IERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRI 474
++ IK+ A E L++ Y + +E H ++ +S S+ +L +
Sbjct: 1325 MQAEIKKLSAEVESLKEAY------HMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
Query: 475 KQLETDSSEEISRYQEMIQKLQNVLESERE 504
K ++ + +S + +Q V+E+ E
Sbjct: 1379 KLELEEAQDTVSNLHQQVQDRNEVIEAANE 1408
Score = 59.7 bits (143), Expect = 9e-09
Identities = 103/521 (19%), Positives = 215/521 (41%), Gaps = 54/521 (10%)
Query: 180 QKQKDQLFDFQQ-LTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVA 238
+K +D++F + +++ E + QQ VT+ L K EL +
Sbjct: 214 KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQN----HSLMTKFESIHFELTQS 269
Query: 239 VAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEA 298
AKV L + + + E+ +++ A D+ L++ ++ ++Q + + Q
Sbjct: 270 RAKVSMLESAQQQA-ASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSL 328
Query: 299 NQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE 358
+ + E L+ E + E +R EA+ A + ++ +K LE+ Q E
Sbjct: 329 QESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYK-KKVAEKLEKVQAE 387
Query: 359 EDIEKMK----ETVSRFVQDATIRTKKEVANTK---KQCNIQISRLTEELSALQMECAEK 411
E+I + E ++ +Q+ K E+ K +Q + + E+L + ++ +E
Sbjct: 388 EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447
Query: 412 QGQIERVIKEKKAVEEELE---KIYREGRGNESDYRKLE----EMHQRFLVSERSKDDLQ 464
Q+ + +E ELE +I R+ ++ R+L+ ++R + ++ + +
Sbjct: 448 MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
Query: 465 LRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERE---------NCGLVSEQRLK 515
+ L E I QL E+ ++ + K Q S +E N ++SE R+K
Sbjct: 508 VELRSLEKIISQLPL--KRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
Query: 516 LQQENKQLRKETESLRKIALEA------QKKAKVKISTMEHEFSIKERGFEVQLREMEDS 569
L + +++K +L L + K+S++E E +K G +V ++D
Sbjct: 566 LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE-PVKLGGHQV-AESVKDQ 623
Query: 570 NRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM 629
N++ T K + ++ E ++ +++E S K++ SQ ++
Sbjct: 624 NQH----------TMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
Query: 630 AN----EKVAENEKLILEHQEKANRLQRRLSQAEERAASAS 666
EK + + KL E +K ++L Q EE+ + S
Sbjct: 674 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYS 714
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 103 bits (257), Expect = 5e-22
Identities = 138/646 (21%), Positives = 275/646 (42%), Gaps = 90/646 (13%)
Query: 69 ELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDE 128
E+NG++ GE +L+ E ++E + L+ E KLE + +
Sbjct: 1357 EINGEVDD-DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEV-------------EQQ 1402
Query: 129 TVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE---HMTEAQIHVFESQKQKDQ 185
R L+ +L + ++ Q + ++ RL Q+ H+ Q+ E +K K +
Sbjct: 1403 NKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEK-KQR 1461
Query: 186 LFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQ---LRKKLRQAKLELRVAVAKV 242
FD +L +E + Q K E+ +++ + L+++L + +++ KV
Sbjct: 1462 RFD-----SELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKV 1516
Query: 243 EELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRL-----CVTIQE 297
L +D+ Q K E + ++L+ L++ +K E L + + E
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVK-------KQLRDLEAKVKDQEEELDEQAGTIQMLE 1569
Query: 298 ANQLRTE---NTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEE 354
+LR E + ++E++++ E+E R + + LEE K + L E+
Sbjct: 1570 QAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK 1629
Query: 355 KQKEEDIEKMKETVSRFVQDATIRTKKEVANTK----------------KQCNIQISRLT 398
++ E + + + V+R ++ R +K++ TK +I++L
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLK 1689
Query: 399 EEL--------------SALQMECAEKQGQIERVIKEKKAVEEELEKIYREG-------R 437
+L A+++E + QI+ + K K A+EE+L ++ RE
Sbjct: 1690 NQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLE 1749
Query: 438 GNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQN 497
++ D +L + H + V++ S+D Q+ +A QLE ++++E QE +Q LQ+
Sbjct: 1750 EDQEDMNELMKKH-KAAVAQASRDLAQINDLQA-----QLE-EANKEKQELQEKLQALQS 1802
Query: 498 ---VLESERENCGLVSEQRLKLQQENKQLRKETESLRKI-ALEAQKKAKVKISTMEHEFS 553
LE + LVS Q K+++ +L E ++++ +L ++ K ++ T E +
Sbjct: 1803 QVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 554 IKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSEL 613
I E + + E LA ++ A+R K E + ES E +L+++L
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADL 1922
Query: 614 SRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAE 659
+L + +E E ENE LI Q+ + Q+R ++ E
Sbjct: 1923 KLAFKRIGDLQAAIEDEMES-DENEDLINSLQDMVTKYQKRKNKLE 1967
Score = 84.0 bits (206), Expect = 4e-16
Identities = 120/634 (18%), Positives = 254/634 (40%), Gaps = 91/634 (14%)
Query: 122 DIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTE---------- 171
++ +E +RN E++Q + +A + + DRL E +E
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES 1307
Query: 172 -AQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIE-------- 222
+Q+ E+ ++ + ++L Q + MEV + ++ ++ I
Sbjct: 1308 ASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA 1367
Query: 223 --QLRKKLRQAKLELRVAVAKV-EELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQ 279
+ R K +A E+ ++ +E + E Q ++ E+ + E S R LQQ
Sbjct: 1368 GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427
Query: 280 LQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENE-------------- 325
L+ ++L L T + N LEK+ R ++ ++ E
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487
Query: 326 ------------------------------RYEAIVRARNSMQLLEEANLQKSQALLEE- 354
EA ++ +S + +EA+L K + L +
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547
Query: 355 ----KQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAE 410
K +EE++++ T+ + ++ A +R + E+ ++ + ++ EE+ + C +
Sbjct: 1548 EAKVKDQEEELDEQAGTI-QMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQK 1606
Query: 411 KQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRA 470
K Q+E ++E+ E+ +K+ RE R E L + R + L+ T+A
Sbjct: 1607 KLKQMEVQLEEE---YEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKA 1663
Query: 471 ENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESL 530
QL D + + + I +L+N LE C + R ++ E + L + + +
Sbjct: 1664 LLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDI 1723
Query: 531 RKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLA------TQ 584
K A A ++ ++ ++E + + + E+ ++ ++ + LA Q
Sbjct: 1724 AK-AKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQ 1782
Query: 585 QKAANRWKEETKKLTESAEIRINNL------KSELSRQKLHTQELLSQLEMANEKVAENE 638
+ AN+ K+E ++ ++ + ++ L KS +SRQ+ +EL ++LE +V E
Sbjct: 1783 LEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLE 1842
Query: 639 KL---ILEHQEKANRLQRRLSQAEERAASASQQL 669
L + E+ EK + + AE R +++L
Sbjct: 1843 SLASRLKENMEKLTEERDQRIAAENREKEQNKRL 1876
Score = 52.0 bits (123), Expect = 2e-06
Identities = 72/390 (18%), Positives = 159/390 (40%), Gaps = 74/390 (18%)
Query: 327 YEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANT 386
Y + R +LLE +L+KS + + + T++R + +T + +
Sbjct: 1140 YIVVDERRAVEELLECLDLEKSSCCMGLSR----VFFRAGTLARLEEQRDEQTSRNLTLF 1195
Query: 387 KKQCNIQISRL---TEELSALQMECAEKQGQIERVIKE----------KKAVEEELEKIY 433
+ C ++R ++ L + C +K + + +K+ + +E +L +
Sbjct: 1196 QAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQ 1255
Query: 434 REGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQ 493
+ E ++++ + +E+ +++L+L R E+RI +L ++ ++E
Sbjct: 1256 IRNKDEE-----IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDE--------- 1301
Query: 494 KLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRK----IALEAQKKAKVKISTME 549
+N ES + + +RL+ ++E K+L+ + ++L+K + +E + ++ + +
Sbjct: 1302 --RNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEIN 1359
Query: 550 HEFSIKERGFEVQLR-----------------------EMEDSNRNSIVELRHLLATQQK 586
E + G E +L+ E+E N+ + L +
Sbjct: 1360 GEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSE 1419
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELL-------SQLEMANEKVAENEK 639
+ R ++ KK + + + K L Q++ EL S+L A+E+ A+ EK
Sbjct: 1420 ESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE-AQREK 1478
Query: 640 LILEHQEKANRLQRRLSQAEERAASASQQL 669
L + +LQR A S QQL
Sbjct: 1479 L------QREKLQREKDMLLAEAFSLKQQL 1502
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 103 bits (256), Expect = 7e-22
Identities = 136/670 (20%), Positives = 290/670 (43%), Gaps = 86/670 (12%)
Query: 69 ELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYA 125
+L G LK Q+ + ++ K QL+ +K+ E S L+ +E + LG ++ I
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE---DEQALGIQLQKKIKE 1116
Query: 126 DDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--HMTEAQIHVFESQKQK 183
+ L+E+++ + +A + +S+EL+ + + +E T AQI + + ++ +
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176
Query: 184 DQLF--DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV---- 237
Q D ++ T Q T + + + + EQ ++++++KL + K E+++
Sbjct: 1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1236
Query: 238 ----------AVAKVEELTNVTEDLQGQMKKKEK-------DVVSAHGREEAS----DRR 276
A +E++ ED ++K KE+ D+ + GR + R+
Sbjct: 1237 LASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ 1296
Query: 277 LQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEA-IVRARN 335
L + ++ + QL Q+ +L+ + LE++ + A + L++ R++ ++R +
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 336 SMQLLEEANLQKSQALLEEK-------------QKEEDIEKMKETVSRFVQDATIRTK-- 380
+ +A LQ++ + + Q+ E++E+ K+ +++ +Q A +
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 381 ----KEVANTKKQCNIQISRLTEELSALQMECA---EKQGQIERVIKE-KKAVEE---EL 429
+ TK++ ++ L ++ CA +KQ ++++ E K+ EE EL
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 430 EKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQ 489
E +E R ++ K++ + E S D L+ L R ++Q +D +E+I+
Sbjct: 1474 EASQKEARSLGTELFKIKNAY------EESLDQLE-TLKRENKNLQQEISDLTEQIAEGG 1526
Query: 490 EMIQKLQNVLES-ERENCGLVSEQRLKLQQENKQLRKETESLRKIALEA-QKKAKV--KI 545
+ I +L+ + + E+E C E + L++ L E + +I LE Q K++V KI
Sbjct: 1527 KRIHELEKIKKQVEQEKC----ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 546 STMEHEFSIKERGFEVQLREMEDS------NRNSIVELRHLLATQQKAANRWKEETKKLT 599
+ + E +R + M+ + +RN + L+ + ++
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 600 ESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAE 659
A N + L ++H + L E E++A E+ Q + L+ L Q E
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 660 ERAASASQQL 669
A Q+L
Sbjct: 1703 RSRKIAEQEL 1712
Score = 99.0 bits (245), Expect = 1e-20
Identities = 144/679 (21%), Positives = 281/679 (41%), Gaps = 107/679 (15%)
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E + + +L+ + + +Q+ E+K QLE IK K+A+ L++ ++
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA--------KNALAHALQSSRHDCDLLR 1350
Query: 122 DIYADD-ETVRNLQEQLQLANQEKTQAVELWQTVS----QELDRLHKLYQEHMTEAQIHV 176
+ Y ++ E+ LQ L AN E Q ++T + +EL+ K + + A+ HV
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 177 ---------FESQKQK--DQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR 225
E KQ+ +++ D ++ + ++ + F K + E E+
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 226 KKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIK 285
+L ++ E R ++ ++ N E+ Q+ E R + LQ I
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQL--------------ETLKRENKNLQQEIS 1516
Query: 286 QLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN--ERYEAIVRARNSMQLLEEA 343
L ++ + ++L +E++ ELQA E E E E + +++ E
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKI-----LRIQLEL 1571
Query: 344 NLQKSQALLEEKQKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRL 397
N KS+ + +K+E+I+++K R V+ DA IR++ + KK+ ++ +
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
+L+ AE K + L+ R E++ ++ + E
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ----------EDLKEQLAMVE 1681
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQ 517
R + LQ + ++Q T+ S +I+ QE++ + V +N L++ ++ KL+
Sbjct: 1682 RRANLLQAEIEELRATLEQ--TERSRKIAE-QELLDASERVQLLHTQNTSLINTKK-KLE 1737
Query: 518 QENKQLRKETESLRKIALEAQKKAKVKIS--TMEHEFSIKERGFEVQLREMEDSNRNSIV 575
+ Q++ E E + + A A++KAK I+ M E KE+ L M+ + ++
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 576 ELR-HLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV 634
+L+ L +Q A K++ +KL E R+ L+ E+ ++ E + L +V
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKL----EARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 635 AE-------NEKLILEHQE----------------------------KANRLQRRLSQAE 659
E + K IL Q+ K +LQ L +AE
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 660 ERAASASQQLSVITVQRRK 678
ERA A Q++ + V+ R+
Sbjct: 1914 ERADIAESQVNKLRVKSRE 1932
Score = 97.8 bits (242), Expect = 3e-20
Identities = 139/663 (20%), Positives = 274/663 (41%), Gaps = 104/663 (15%)
Query: 80 QVGEMKLQLENVIKE-------NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Q+ + K+QLE IKE E +++EL A ++KLE +E+ DI + T+
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELT-AKKRKLE--DECSELKKDIDDLELTLAK 969
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
++++ + E + + + +L K + Q + + Q ++D++ +
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
+L +++E + +Q K + +E+ ++KL +L++A + ++ N + L
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMD----LERAKRKLEG---DLKLAQESIMDIENEKQQL 1082
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
++KKKE ++ + + E QLQ IK+L+ R+ +E R EKQ
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 313 RELQAKCNELENERYEA--IVRARNSMQLLEEANLQKSQALLEE---------------- 354
+L + E+ EA A+ M EA QK + LEE
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 355 --------------KQKEEDIEKMKETVSRFVQD--ATIRT-KKEVANTKKQCNI---QI 394
++ ++ +EK K + + D + + T K N +K C Q+
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 395 S----------RLTEELSALQMECAEKQGQIERVIKEKKA-------------------- 424
S RL +L+A + + G+ R + EK+A
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 425 --VEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQ----LE 478
+EEE++ +S + + +++ + SK +LQ L++A + Q E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 479 TDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQ 538
TD+ + +E +KL L++ E+ V+ + L++ ++L+ E E L + +E
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL-MLDVERT 1441
Query: 539 KKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKE--ETK 596
A + K+R F+ L E + + EL A+Q++A + E + K
Sbjct: 1442 NAACAALDK-------KQRNFDKILAEWKQKCEETHAELE---ASQKEARSLGTELFKIK 1491
Query: 597 KLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS 656
E + ++ LK E + +L Q+ +++ E EK+ + +++ LQ L
Sbjct: 1492 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551
Query: 657 QAE 659
+AE
Sbjct: 1552 EAE 1554
Score = 97.4 bits (241), Expect = 4e-20
Identities = 144/737 (19%), Positives = 301/737 (40%), Gaps = 100/737 (13%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQK-AVCQGEGDDTFENLVFDQSFLAPL 59
+ +ID L+ ++L ++ +ME S+V+ + +G + L S L
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEV 119
E + + +L Q Q + GE QL+ E E L S+L +
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLD----EKEALVSQLSRGKQ------------ 1312
Query: 120 GTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHM---------- 169
A + + L+ QL+ + K Q+ + D L + Y+E
Sbjct: 1313 -----AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRAL 1367
Query: 170 --TEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKK 227
++ + ++ + D + ++L + + ++ ++ ++ V + +E+ +++
Sbjct: 1368 SKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA-EEHVEAVNAKCASLEKTKQR 1426
Query: 228 LRQAKLELRVAVAKVEELTNVTEDLQGQMKK-----KEKDVVSAHGREEASDRRLQQLQS 282
L+ +L + V + + Q K K+K H EAS + + L +
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK-CEETHAELEASQKEARSLGT 1485
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLE--------------KQTRELQAKCNELENERYE 328
+ +++ ++ + L+ EN +L+ K+ EL+ ++E E+ E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 329 ---AIVRARNSMQLLE--------EANLQKSQALLEEKQKEEDIEKMKETVSRFVQ---- 373
A+ A S++ E E N KS+ + +K+E+I+++K R V+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 374 --DATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK 431
DA IR++ + KK+ ++ + +L+ AE K + L
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL-- 1663
Query: 432 IYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEM 491
+ R E++ ++ + ER + LQ + ++Q T+ S +I+ QE+
Sbjct: 1664 --------DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ--TERSRKIAE-QEL 1712
Query: 492 IQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKI--STME 549
+ + V +N L++ ++ KL+ + Q++ E E + + A A++KAK I + M
Sbjct: 1713 LDASERVQLLHTQNTSLINTKK-KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 550 HEFSIKERGFEVQLREMEDSNRNSIVELR-HLLATQQKAANRWKEETKKLTESAEIRINN 608
E KE+ L M+ + ++ +L+ L +Q A K++ +KL E R+
Sbjct: 1772 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL----EARVRE 1827
Query: 609 LKSELSRQKLHTQELLSQLEMANEKV-------AENEKLILEHQEKANRLQRRLSQAEER 661
L+ E+ ++ E + L +V E+ K IL Q+ ++LQ ++ + +
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 662 AASASQQLSVITVQRRK 678
A A +Q + + RK
Sbjct: 1888 AEEAEEQSNTNLAKFRK 1904
Score = 83.2 bits (204), Expect = 7e-16
Identities = 88/463 (19%), Positives = 201/463 (43%), Gaps = 43/463 (9%)
Query: 87 QLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQ---LQLANQE 143
QLE + +EN+ L E+ D E+ E G I+ ++ + ++++ LQ A +E
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEG-------GKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 144 KTQAVELWQ----TVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVT 199
++E + + EL+++ + E + + ++ ++ + Q T +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 200 NENMEVT---------NQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTE 250
+ N + N+ ++ + E LR R + L+ +++ E
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN-YRNTQGILKDTQIHLDDALRSQE 1671
Query: 251 DLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEK 310
DL+ Q+ E+ E L+Q + S K E L + L T+NT L
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731
Query: 311 QTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED----IEKMKE 366
++L+ ++++ E + + ARN+ + ++A + + + EE +KE+D +E+MK+
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKK 1790
Query: 367 TVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVE 426
+ + V+D +R + K QI +L + L+ E +Q + +K + E
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 427 EELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEIS 486
++++ + + + +L+++ D LQ ++ + + ++ E S+ ++
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDL----------VDKLQAKVKSYKRQAEEAEEQSNTNLA 1900
Query: 487 RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
++ +KLQ+ LE E + Q KL+ +++++ + S
Sbjct: 1901 KF----RKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Score = 77.0 bits (188), Expect = 5e-14
Identities = 94/492 (19%), Positives = 210/492 (42%), Gaps = 58/492 (11%)
Query: 222 EQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
++++ +L +++ + + K+ L DLQ Q++ + + + A R + + QL+
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922
Query: 282 SSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLE 341
+ IK++ + A N L + R+L+ +C+EL+ + + L
Sbjct: 923 AKIKEV-------TERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---------ELT 966
Query: 342 EANLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRL 397
A ++K + E K K E++ + ET+++ ++ A ++ + + +++ L
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
T+ L+ + + +G +E ++K + +LE+ R+ G+ L+ + + E
Sbjct: 1027 TKAKIKLEQQVDDLEGSLE----QEKKLRMDLERAKRKLEGD------LKLAQESIMDIE 1076
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCG 507
K L +L + E I L++ +E I Q I++L+ +E+ER +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 508 LVSEQRLKLQQENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLR 564
+QR L +E +++ + E +E KK + + M + E
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 565 EMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQE-- 622
+ + +S+ EL + Q+ + ++E ++ + +N+++ +S+ K + ++
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET-VSKAKGNLEKMC 1255
Query: 623 --LLSQLEMANEKVAENEKLILEHQEKANRLQRRLS----QAEERAASASQQLSVITVQR 676
L QL K E ++LI + + RLQ Q +E+ A SQ + R
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ------LSR 1309
Query: 677 RKAASLMNLENI 688
K A +E +
Sbjct: 1310 GKQAFTQQIEEL 1321
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 103 bits (256), Expect = 7e-22
Identities = 136/670 (20%), Positives = 290/670 (43%), Gaps = 86/670 (12%)
Query: 69 ELNGQLKYYQKQVGEM---KLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYA 125
+L G LK Q+ + ++ K QL+ +K+ E S L+ +E + LG ++ I
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE---DEQALGIQLQKKIKE 1116
Query: 126 DDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--HMTEAQIHVFESQKQK 183
+ L+E+++ + +A + +S+EL+ + + +E T AQI + + ++ +
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176
Query: 184 DQLF--DFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV---- 237
Q D ++ T Q T + + + + EQ ++++++KL + K E+++
Sbjct: 1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1236
Query: 238 ----------AVAKVEELTNVTEDLQGQMKKKEK-------DVVSAHGREEAS----DRR 276
A +E++ ED ++K KE+ D+ + GR + R+
Sbjct: 1237 LASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ 1296
Query: 277 LQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEA-IVRARN 335
L + ++ + QL Q+ +L+ + LE++ + A + L++ R++ ++R +
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 336 SMQLLEEANLQKSQALLEEK-------------QKEEDIEKMKETVSRFVQDATIRTK-- 380
+ +A LQ++ + + Q+ E++E+ K+ +++ +Q A +
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 381 ----KEVANTKKQCNIQISRLTEELSALQMECA---EKQGQIERVIKE-KKAVEE---EL 429
+ TK++ ++ L ++ CA +KQ ++++ E K+ EE EL
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 430 EKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQ 489
E +E R ++ K++ + E S D L+ L R ++Q +D +E+I+
Sbjct: 1474 EASQKEARSLGTELFKIKNAY------EESLDQLE-TLKRENKNLQQEISDLTEQIAEGG 1526
Query: 490 EMIQKLQNVLES-ERENCGLVSEQRLKLQQENKQLRKETESLRKIALEA-QKKAKV--KI 545
+ I +L+ + + E+E C E + L++ L E + +I LE Q K++V KI
Sbjct: 1527 KRIHELEKIKKQVEQEKC----ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 546 STMEHEFSIKERGFEVQLREMEDS------NRNSIVELRHLLATQQKAANRWKEETKKLT 599
+ + E +R + M+ + +RN + L+ + ++
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 600 ESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAE 659
A N + L ++H + L E E++A E+ Q + L+ L Q E
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 660 ERAASASQQL 669
A Q+L
Sbjct: 1703 RSRKIAEQEL 1712
Score = 99.0 bits (245), Expect = 1e-20
Identities = 144/679 (21%), Positives = 281/679 (41%), Gaps = 107/679 (15%)
Query: 62 EYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT 121
E + + +L+ + + +Q+ E+K QLE IK K+A+ L++ ++
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA--------KNALAHALQSSRHDCDLLR 1350
Query: 122 DIYADD-ETVRNLQEQLQLANQEKTQAVELWQTVS----QELDRLHKLYQEHMTEAQIHV 176
+ Y ++ E+ LQ L AN E Q ++T + +EL+ K + + A+ HV
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 177 ---------FESQKQK--DQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR 225
E KQ+ +++ D ++ + ++ + F K + E E+
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 226 KKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIK 285
+L ++ E R ++ ++ N E+ Q+ E R + LQ I
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQL--------------ETLKRENKNLQQEIS 1516
Query: 286 QLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN--ERYEAIVRARNSMQLLEEA 343
L ++ + ++L +E++ ELQA E E E E + +++ E
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKI-----LRIQLEL 1571
Query: 344 NLQKSQALLEEKQKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQISRL 397
N KS+ + +K+E+I+++K R V+ DA IR++ + KK+ ++ +
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
+L+ AE K + L+ R E++ ++ + E
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ----------EDLKEQLAMVE 1681
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQ 517
R + LQ + ++Q T+ S +I+ QE++ + V +N L++ ++ KL+
Sbjct: 1682 RRANLLQAEIEELRATLEQ--TERSRKIAE-QELLDASERVQLLHTQNTSLINTKK-KLE 1737
Query: 518 QENKQLRKETESLRKIALEAQKKAKVKIS--TMEHEFSIKERGFEVQLREMEDSNRNSIV 575
+ Q++ E E + + A A++KAK I+ M E KE+ L M+ + ++
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 576 ELR-HLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKV 634
+L+ L +Q A K++ +KL E R+ L+ E+ ++ E + L +V
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKL----EARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 635 AE-------NEKLILEHQE----------------------------KANRLQRRLSQAE 659
E + K IL Q+ K +LQ L +AE
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 660 ERAASASQQLSVITVQRRK 678
ERA A Q++ + V+ R+
Sbjct: 1914 ERADIAESQVNKLRVKSRE 1932
Score = 97.8 bits (242), Expect = 3e-20
Identities = 139/663 (20%), Positives = 274/663 (41%), Gaps = 104/663 (15%)
Query: 80 QVGEMKLQLENVIKE-------NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN 132
Q+ + K+QLE IKE E +++EL A ++KLE +E+ DI + T+
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELT-AKKRKLE--DECSELKKDIDDLELTLAK 969
Query: 133 LQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQL 192
++++ + E + + + +L K + Q + + Q ++D++ +
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 193 TKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDL 252
+L +++E + +Q K + +E+ ++KL +L++A + ++ N + L
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMD----LERAKRKLEG---DLKLAQESIMDIENEKQQL 1082
Query: 253 QGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQT 312
++KKKE ++ + + E QLQ IK+L+ R+ +E R EKQ
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 313 RELQAKCNELENERYEA--IVRARNSMQLLEEANLQKSQALLEE---------------- 354
+L + E+ EA A+ M EA QK + LEE
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 355 --------------KQKEEDIEKMKETVSRFVQD--ATIRT-KKEVANTKKQCNI---QI 394
++ ++ +EK K + + D + + T K N +K C Q+
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 395 S----------RLTEELSALQMECAEKQGQIERVIKEKKA-------------------- 424
S RL +L+A + + G+ R + EK+A
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 425 --VEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQ----LE 478
+EEE++ +S + + +++ + SK +LQ L++A + Q E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 479 TDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQ 538
TD+ + +E +KL L++ E+ V+ + L++ ++L+ E E L + +E
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL-MLDVERT 1441
Query: 539 KKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKE--ETK 596
A + K+R F+ L E + + EL A+Q++A + E + K
Sbjct: 1442 NAACAALDK-------KQRNFDKILAEWKQKCEETHAELE---ASQKEARSLGTELFKIK 1491
Query: 597 KLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS 656
E + ++ LK E + +L Q+ +++ E EK+ + +++ LQ L
Sbjct: 1492 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551
Query: 657 QAE 659
+AE
Sbjct: 1552 EAE 1554
Score = 97.4 bits (241), Expect = 4e-20
Identities = 144/737 (19%), Positives = 301/737 (40%), Gaps = 100/737 (13%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQK-AVCQGEGDDTFENLVFDQSFLAPL 59
+ +ID L+ ++L ++ +ME S+V+ + +G + L S L
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 60 VTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEV 119
E + + +L Q Q + GE QL+ E E L S+L +
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLD----EKEALVSQLSRGKQ------------ 1312
Query: 120 GTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHM---------- 169
A + + L+ QL+ + K Q+ + D L + Y+E
Sbjct: 1313 -----AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRAL 1367
Query: 170 --TEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKK 227
++ + ++ + D + ++L + + ++ ++ ++ V + +E+ +++
Sbjct: 1368 SKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA-EEHVEAVNAKCASLEKTKQR 1426
Query: 228 LRQAKLELRVAVAKVEELTNVTEDLQGQMKK-----KEKDVVSAHGREEASDRRLQQLQS 282
L+ +L + V + + Q K K+K H EAS + + L +
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK-CEETHAELEASQKEARSLGT 1485
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLE--------------KQTRELQAKCNELENERYE 328
+ +++ ++ + L+ EN +L+ K+ EL+ ++E E+ E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 329 ---AIVRARNSMQLLE--------EANLQKSQALLEEKQKEEDIEKMKETVSRFVQ---- 373
A+ A S++ E E N KS+ + +K+E+I+++K R V+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 374 --DATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEK 431
DA IR++ + KK+ ++ + +L+ AE K + L
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL-- 1663
Query: 432 IYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEM 491
+ R E++ ++ + ER + LQ + ++Q T+ S +I+ QE+
Sbjct: 1664 --------DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ--TERSRKIAE-QEL 1712
Query: 492 IQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKI--STME 549
+ + V +N L++ ++ KL+ + Q++ E E + + A A++KAK I + M
Sbjct: 1713 LDASERVQLLHTQNTSLINTKK-KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 550 HEFSIKERGFEVQLREMEDSNRNSIVELR-HLLATQQKAANRWKEETKKLTESAEIRINN 608
E KE+ L M+ + ++ +L+ L +Q A K++ +KL E R+
Sbjct: 1772 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL----EARVRE 1827
Query: 609 LKSELSRQKLHTQELLSQLEMANEKV-------AENEKLILEHQEKANRLQRRLSQAEER 661
L+ E+ ++ E + L +V E+ K IL Q+ ++LQ ++ + +
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 662 AASASQQLSVITVQRRK 678
A A +Q + + RK
Sbjct: 1888 AEEAEEQSNTNLAKFRK 1904
Score = 83.2 bits (204), Expect = 7e-16
Identities = 88/463 (19%), Positives = 201/463 (43%), Gaps = 43/463 (9%)
Query: 87 QLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQ---LQLANQE 143
QLE + +EN+ L E+ D E+ E G I+ ++ + ++++ LQ A +E
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEG-------GKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 144 KTQAVELWQ----TVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVT 199
++E + + EL+++ + E + + ++ ++ + Q T +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 200 NENMEVT---------NQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTE 250
+ N + N+ ++ + E LR R + L+ +++ E
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN-YRNTQGILKDTQIHLDDALRSQE 1671
Query: 251 DLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEK 310
DL+ Q+ E+ E L+Q + S K E L + L T+NT L
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731
Query: 311 QTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEED----IEKMKE 366
++L+ ++++ E + + ARN+ + ++A + + + EE +KE+D +E+MK+
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKK 1790
Query: 367 TVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVE 426
+ + V+D +R + K QI +L + L+ E +Q + +K + E
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 427 EELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEIS 486
++++ + + + +L+++ D LQ ++ + + ++ E S+ ++
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDL----------VDKLQAKVKSYKRQAEEAEEQSNTNLA 1900
Query: 487 RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETES 529
++ +KLQ+ LE E + Q KL+ +++++ + S
Sbjct: 1901 KF----RKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Score = 77.0 bits (188), Expect = 5e-14
Identities = 94/492 (19%), Positives = 210/492 (42%), Gaps = 58/492 (11%)
Query: 222 EQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
++++ +L +++ + + K+ L DLQ Q++ + + + A R + + QL+
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922
Query: 282 SSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLE 341
+ IK++ + A N L + R+L+ +C+EL+ + + L
Sbjct: 923 AKIKEV-------TERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---------ELT 966
Query: 342 EANLQKSQALLEEKQKE--EDIEKMKETVSRFVQD--ATIRTKKEVANTKKQCNIQISRL 397
A ++K + E K K E++ + ET+++ ++ A ++ + + +++ L
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
T+ L+ + + +G +E ++K + +LE+ R+ G+ L+ + + E
Sbjct: 1027 TKAKIKLEQQVDDLEGSLE----QEKKLRMDLERAKRKLEGD------LKLAQESIMDIE 1076
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCG 507
K L +L + E I L++ +E I Q I++L+ +E+ER +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 508 LVSEQRLKLQQENKQLRKETE---SLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLR 564
+QR L +E +++ + E +E KK + + M + E
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 565 EMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQE-- 622
+ + +S+ EL + Q+ + ++E ++ + +N+++ +S+ K + ++
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET-VSKAKGNLEKMC 1255
Query: 623 --LLSQLEMANEKVAENEKLILEHQEKANRLQRRLS----QAEERAASASQQLSVITVQR 676
L QL K E ++LI + + RLQ Q +E+ A SQ + R
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ------LSR 1309
Query: 677 RKAASLMNLENI 688
K A +E +
Sbjct: 1310 GKQAFTQQIEEL 1321
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 102 bits (255), Expect = 9e-22
Identities = 136/698 (19%), Positives = 292/698 (41%), Gaps = 84/698 (12%)
Query: 67 LGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYAD 126
L +L Q+ Q+++ + QL + +E L + A EA LG T+
Sbjct: 1582 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH 1641
Query: 127 DETVRNLQEQLQLANQE--------KTQAVELWQTVSQELDRLHKLYQE---HMTEAQIH 175
V++L E+L E KTQ + Q + +E + L + ++ H TE +
Sbjct: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
Query: 176 VFESQKQKDQL----FDFQQLTKQLHVTN----------ENMEVTNQQFLKTVTEQSVII 221
+ Q + +L Q +L T EN++ +QQ + Q ++
Sbjct: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
Query: 222 EQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQ 281
E+ ++++ + E R + VE L+ EDLQ + EK + A++ + Q
Sbjct: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
Query: 282 SSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELE---NERYEAIVRARNSMQ 338
S++++LE+ + QE +QL + L +Q + E N E + ++ +
Sbjct: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
Query: 339 LL----------------EEANLQKSQA----LLEEKQKEEDIE---------KMKETVS 369
L E+ LQK + E+ QKEE+ + +++E
Sbjct: 1882 LAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKL 1941
Query: 370 RFVQDATIRTKKEVANTKKQCNIQISRLT--EELSALQMECAEKQGQIERVIKEKKAVEE 427
+ VQ + + + ++ ++ S++T E+ L+ E +++ ++++V+ + A EE
Sbjct: 1942 KLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
Query: 428 ELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSS----- 482
+ + E R ES + L + ++ E+ + L + + D S
Sbjct: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
Query: 483 --EEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKK 540
E + ++ + L+ L+ +R + + L+ +QEN ++KE ++ +A + ++
Sbjct: 2062 FLTERKKAEKQVASLKEALKIQRSQ---LEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
Query: 541 AK---VKISTMEHEFS------IKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRW 591
A+ +++ M++E++ ++ E + E+ D+ R E++ + T K N++
Sbjct: 2119 ARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQF 2178
Query: 592 KEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRL 651
E E+ R NL+ EL K + +++ EK+ ++ I++ + L
Sbjct: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGPF-EEKLNFSQVHIMDEHWRGEAL 2237
Query: 652 QRRLSQAEERAAS-----ASQQLSVITVQRRKAASLMN 684
+ +L E+R + S+Q V+ +R+ ++
Sbjct: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
Score = 85.9 bits (211), Expect = 1e-16
Identities = 125/554 (22%), Positives = 244/554 (44%), Gaps = 59/554 (10%)
Query: 139 LANQEKTQAVELWQTVSQELDRLHKLYQEHMTEA------QIHVFESQKQKDQLFDFQQL 192
+ Q++ +A E + +E++RL + ++ M E Q E K +D+L + L
Sbjct: 255 VTTQDRQEAFERFSL--EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN--KSL 310
Query: 193 TKQLHVTNENMEV------TNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVE--- 243
++ + ++ E T + LK T IE R +Q +LE +A K++
Sbjct: 311 KEEAMLQKQSCEELKSDLNTKNELLKQKT-----IELTRACQKQYELEQELAFYKIDAKF 365
Query: 244 ELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEAN-QLR 302
E N ++ K + S + + R + +S I + + E + QLR
Sbjct: 366 EPLNYYPSEYAEIDKAPDE--SPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
Query: 303 TENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIE 362
++ +L T L + + E + A R +E+A Q +A E KQ EE I+
Sbjct: 424 NDHMNLRGHT-PLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ 482
Query: 363 KMKETVSRFVQDATIRT---KKEVANTKKQ----CNIQISRLTEELSALQMECAEKQGQI 415
K +S +D + + ++ N +Q +Q+ + +E++ Q E + Q I
Sbjct: 483 LKK--ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI 540
Query: 416 ERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
+ + + K + K + G+ + D M++++ E D++ R+ + IK
Sbjct: 541 DSL--DSKDPKHSHMKAQKSGKEQQLDI-----MNKQYQQLESRLDEILSRIAKETEEIK 593
Query: 476 QLETDSSE-EISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIA 534
LE +E +I+ + + + L+ V+ +E G + Q + Q E ++LR E E+L +
Sbjct: 594 DLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
Query: 535 LEA-QKKAKVKISTMEHEFSIKERG-FEVQLREMEDSNRNSI----------VELRHLLA 582
E Q++ +++I M+ E KE E L+E + N + EL L
Sbjct: 654 TEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLN 713
Query: 583 TQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKL-- 640
+ AN+ KEE +K+T ++ + L++EL +++ + L + + + EK EN +L
Sbjct: 714 LRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHA 773
Query: 641 ILEHQEKANRLQRR 654
L+H + N L ++
Sbjct: 774 KLKHLQDDNNLLKQ 787
Score = 83.2 bits (204), Expect = 7e-16
Identities = 150/623 (24%), Positives = 267/623 (42%), Gaps = 90/623 (14%)
Query: 69 ELNGQLKYYQK---QVGEMKLQLENVIKENERLHSELKD---AVEKKLEAFPLGTEVGTD 122
+L+G+L+ K + +++LQ+E +E E+KD A++ P + +
Sbjct: 497 QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
Query: 123 IYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQ 182
++ + + +Q Q Q +++ E+ +++E + + L +E +TE QI E+ K+
Sbjct: 557 KSGKEQQLDIMNKQYQ---QLESRLDEILSRIAKETEEIKDL-EEQLTEGQIAANEALKK 612
Query: 183 KDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKV 242
D + + L Q++L T+ Q+ + +KLR K L + +V
Sbjct: 613 -----DLEGVISGL-----------QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV 656
Query: 243 EE----LTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIK----QLEIRLCVT 294
E+ L V D + M+K+ ++ SA + + LQQ Q + +LE RL +
Sbjct: 657 EQERDQLEIVAMDAEN-MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLR 715
Query: 295 IQEANQLRTENTHLEKQTR----ELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQA 350
EANQL+ E LEK TR E A ELE ER +A+ A Q EE + S+
Sbjct: 716 DAEANQLKEE---LEKVTRLTQLEQSALQAELEKER-QALKNALGKAQFSEEKEQENSEL 771
Query: 351 LLEEKQKEEDIEKMKETVSRF------VQDATIRTKKEVANTKK----------QCNIQI 394
+ K ++D +K+ + F V D +R ++ A + + NI
Sbjct: 772 HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHS 831
Query: 395 SR--LTEELSALQMECAE-----KQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLE 447
L + L+ LQ + +E K + E ++E+K EE + + G E +
Sbjct: 832 PSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE----EFR 887
Query: 448 EMHQRFLVSERSKDDLQ--LRLTRAENRIKQLETD--SSEEIS-----RYQEMIQKLQNV 498
+ +R L + + D Q R+ + EN I L+ + S EEI + QE ++ + +
Sbjct: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Query: 499 LESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERG 558
L RE + K Q++ L KE + L+K + K A +++ + + G
Sbjct: 948 LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK-SLHG 1006
Query: 559 FEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIR-INNLKSELSRQK 617
+++ N+ EL+ +KAA ++ T+ AEI + NL + Q
Sbjct: 1007 TVMKI------NQERAEELQEAERFSRKAAQAARDLTR---AEAEIELLQNLLRQKGEQF 1057
Query: 618 LHTQELLSQLEMANEKVAENEKL 640
E AN +V E EKL
Sbjct: 1058 RLEMEKTGVGTGANSQVLEIEKL 1080
Score = 82.8 bits (203), Expect = 1e-15
Identities = 126/660 (19%), Positives = 270/660 (40%), Gaps = 106/660 (16%)
Query: 70 LNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDET 129
L+ QL+ +K++ + +L LH E++ A ++ L A E
Sbjct: 435 LDTQLEDKEKKISAAQTRLSE-------LHDEIEKAEQQILRA--------------TEE 473
Query: 130 VRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDF 189
+ L+E +QL + L++ +S L ++KL QE + + +KQK ++
Sbjct: 474 FKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLE----LQMEKQKQEIAGK 529
Query: 190 QQLTKQLHVT---------------------NENMEVTNQQF----------LKTVTEQS 218
Q+ K L + + +++ N+Q+ L + +++
Sbjct: 530 QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
Query: 219 VIIEQLRKKLRQAKLELRVAVAK-----VEELTNVTEDLQGQMKKKEKDVVSAHGREEAS 273
I+ L ++L + ++ A+ K + L ++GQ + + + +E
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
Query: 274 DRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLE---KQTRELQAKCNELENE--RYE 328
+RL +++ QLEI +A +R E LE ++ E+ A + + + YE
Sbjct: 650 LQRLTEVEQERDQLEI----VAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705
Query: 329 AIVRARNSM------QLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKE 382
A + AR ++ QL EE LE+ + ++EK ++ + + A +KE
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
Query: 383 VANTKKQCNIQISRLTEELSALQMECAEKQGQIERVI------KEKKAVEEELEKIYREG 436
N+ + + ++ L ++ + L+ + + Q + V+ +E A +EL + + G
Sbjct: 766 QENS--ELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
Query: 437 RGNESDY-------RKLEEMHQRFL-VSERSK---DDLQLRLTRAENRI----KQLETDS 481
G + + + L ++ ++F + RSK D+ Q+R + + + ++L T
Sbjct: 824 TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQ 883
Query: 482 SEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKA 541
E + ++ N + + E E + QEN + +E + L + L+ +
Sbjct: 884 EEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEE 943
Query: 542 KVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTES 601
K +I E K++ + + +E + +L+ +AT K A T +LT
Sbjct: 944 KERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA------TAELT-I 996
Query: 602 AEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEER 661
A+ ++ +L + + E L + E + K A+ + + + + LQ L Q E+
Sbjct: 997 AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
Score = 71.2 bits (173), Expect = 3e-12
Identities = 113/575 (19%), Positives = 233/575 (40%), Gaps = 76/575 (13%)
Query: 154 VSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKT 213
VS+ D + L + E + + Q +K+ + + L +++E ++ +T
Sbjct: 1325 VSRLEDIMQHLKSKKREERWMRASKRQSEKE-MEELHHNIDDLLQEKKSLECEVEELHRT 1383
Query: 214 VTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEAS 273
V ++ Q +K +E + ++E+ ED+ +++ EK ++ +
Sbjct: 1384 VQKR-----QQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREA 1438
Query: 274 DRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRA 333
DR L + +S L T ++ + T ++ + ++ ELE E V
Sbjct: 1439 DRLLAEAES-------ELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
Query: 334 RNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQ 393
+ Q L + ++EE ++++ + V+ D +KK+
Sbjct: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKK----------- 1540
Query: 394 ISRLTEELSALQ--MECAEK-QGQIERVIKEK----KAVEEELEKIYREGRGNESDY--- 443
+LTEEL LQ +E AE+ + +V+KE +A ELEK+ + + +
Sbjct: 1541 -EKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL 1599
Query: 444 -----RKLEEMHQRFLVSERSKDDLQ--LRLTRAE-----NRIKQLET----------DS 481
K EE+H ++K DLQ LRL E N I+++++ +
Sbjct: 1600 DRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
Query: 482 SEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENK----QLRKETESLRKIALEA 537
+ +IS + + ++ +E E EN +V Q K + E K L+ E L+ + L+
Sbjct: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQH 1719
Query: 538 QKKA----KVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKE 593
++ K +++ +E + ++ L+++ + I + LL ++ R
Sbjct: 1720 DQRVSELEKTQVAVLEEKLELE------NLQQISQQQKGEIEWQKQLLERDKREIERMTA 1773
Query: 594 ETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEK----AN 649
E++ L E ++ K +L + ++ L+Q + EN K+ + EK
Sbjct: 1774 ESRALQSCVEC-LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
Query: 650 RLQRRLSQAEERAASASQQLSVITVQRRKAASLMN 684
+LQ+ L Q S +S + Q ++ +N
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVN 1867
Score = 64.7 bits (156), Expect = 3e-10
Identities = 82/418 (19%), Positives = 181/418 (43%), Gaps = 48/418 (11%)
Query: 295 IQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRA--RNSMQLLEEANLQKSQALL 352
+ E + L E + LE + L++K +R E +RA R S + +EE + L
Sbjct: 1315 VPEHHNLENEVSRLEDIMQHLKSK------KREERWMRASKRQSEKEMEELHHNIDDLLQ 1368
Query: 353 EEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQ 412
E+K E ++E++ TV + Q V + + I+ S E ++EC
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDF-IDGNVESLMTELEIEKSLKHHEDIVDEIEC---- 1423
Query: 413 GQIERVIKEKKAVEEELEKIYREGRGN--------ESDYRKLEEMHQRFLVSERSKDDLQ 464
IE+ + ++++ E +++ E ++ K + + L +E ++L+
Sbjct: 1424 --IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 1481
Query: 465 LR-------LTRAENRIKQLETDSSE---EISRYQEMIQKLQNVLESERENCGLVSEQRL 514
R L +A+ +++ L+ D+ + + +E+++++ ++ ++ + +S+++
Sbjct: 1482 RRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE 1541
Query: 515 KLQQENKQLRKETESLRKIA---LEAQKKAKVKISTMEHEFSIKERGFEVQLREME--DS 569
KL +E ++L+K+ E + L+ K+++V + E + Q +EM D
Sbjct: 1542 KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
Query: 570 NRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM 629
E HLL A +E +L E+ E++ + H +E+ S LE
Sbjct: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGET----------EVTEKCNHIREVKSLLEE 1651
Query: 630 ANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLEN 687
+ + E I E + + +++ + + EE +Q+S + + ++ LEN
Sbjct: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN 1709
Score = 34.7 bits (78), Expect = 0.30
Identities = 51/257 (19%), Positives = 105/257 (40%), Gaps = 23/257 (8%)
Query: 4 EIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEY 63
E D + + R+L E+ Q K ++ Q+ Q + FD+ + +
Sbjct: 857 ERDEAQVRERKLQEEMALQQ----EKLATGQEEFRQACERALEARMNFDKRQHEARIQQM 912
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDI 123
+ + L LK ++ G LQL+ +E ER+ ++L++ +KK E +
Sbjct: 913 ENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE---QV 969
Query: 124 YADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLH----KLYQEHMTEAQIHVFES 179
+ D+ ++ L++ +A +K EL +L LH K+ QE E Q S
Sbjct: 970 FGLDKELKKLKK--AVATSDKLATAEL-TIAKDQLKSLHGTVMKINQERAEELQEAERFS 1026
Query: 180 QKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSV-------IIEQLRKKLRQAK 232
+K D + ++ + + +QF + + V ++E +KL +
Sbjct: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE--IEKLNETM 1084
Query: 233 LELRVAVAKVEELTNVT 249
R +A+++ + ++T
Sbjct: 1085 ERQRTEIARLQNVLDLT 1101
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 102 bits (254), Expect = 1e-21
Identities = 142/722 (19%), Positives = 294/722 (40%), Gaps = 87/722 (12%)
Query: 6 DFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTE--- 62
DF R + + RR ++E +K Q + ENL+ + L+
Sbjct: 859 DFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL 918
Query: 63 YDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD 122
+ + EL +L+ ++ E+ + N+ + L ++ D +E L T+V +
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD-LELTL------TKVEKE 971
Query: 123 IYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQ 182
+A + V+NL E++ T E +++E L + +Q+ + + Q+ +
Sbjct: 972 KHATENKVKNLSEEM-------TALEENISKLTKEKKSLQEAHQQTLDDLQV-------E 1017
Query: 183 KDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKV 242
+D++ ++ +L +++E + +Q K + +E+ ++KL +L+++ +
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD----LERAKRKLEG---DLKMSQESI 1070
Query: 243 EELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLR 302
+L N + ++ ++KKKE ++ + + Q Q IK+L+ R+ +E
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130
Query: 303 TENTHLEKQTRELQAKCNELENERYEA--IVRARNSMQLLEEANLQKSQALLEEKQKEED 360
T +EKQ +L + E+ EA A+ M EA QK + LEE +
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH- 1189
Query: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK 420
E T+ + D+ +++ N ++ +L +E S L+ME + IE + K
Sbjct: 1190 -EATAATLRKKQADSVAELGEQIDNLQRVKQ----KLEKEKSELKMEIDDMASNIEALSK 1244
Query: 421 EKKAVEEE---LEKIYREGRGNESDYRKL-EEMHQRFLVSERSKDDLQLRLTRAENRIKQ 476
K +E +E + E + + +L +++ + + +L R+ E+ I Q
Sbjct: 1245 SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304
Query: 477 LE------TDSSEEISRYQEMIQKLQNV----LESERENCGLVSEQRLKLQQENKQLRKE 526
L T EE+ R E K +N L+S R +C L+ EQ + Q+ +L++
Sbjct: 1305 LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQ- 585
+ + K + E ++ +L+E E++ + + L T+Q
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
Query: 586 ------------------------------KAANRWKE---ETKKLTESAEIRINNLKSE 612
K WK+ E++ E+A+ +L +E
Sbjct: 1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 613 LSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVI 672
L + + +E++ QLE + ++ I + E+ + L +AE+ Q+ S +
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL 1544
Query: 673 TV 674
V
Sbjct: 1545 QV 1546
Score = 100 bits (250), Expect = 3e-21
Identities = 151/749 (20%), Positives = 309/749 (41%), Gaps = 118/749 (15%)
Query: 1 MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFEN--LVFDQSFLAP 58
MA+ I+ L + + R + + FS+ + + Q D + L L+
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVE-DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSH 1293
Query: 59 LVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTE 118
V E + + +L + +Q+ E+K Q+E K K+A+ L++ +
Sbjct: 1294 RVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA--------KNAMAHALQSSRHDCD 1345
Query: 119 VGTDIYADDETVR-NLQEQLQLANQEKTQAVELWQTVS----QELDRLHKLYQEHMTEAQ 173
+ + Y +++ + LQ L AN E Q ++T + +EL+ K + + EA+
Sbjct: 1346 LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405
Query: 174 IHV---------FESQKQKDQ--LFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIE 222
+ E KQ+ Q + D + ++ H ++ + F K + E ++
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD 1465
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQS 282
+ + +L A+ E R ++ ++ N E++ Q+ E R + LQ
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL--------------ETLRRENKNLQE 1511
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEE 342
I L ++ T + + +E++ +LQ E+E + S L +
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS-----LEHEESKILRVQ 1566
Query: 343 ANLQKSQALLEEK--QKEEDIEKMKETVSRFVQ------DATIRTKKEVANTKKQCNIQI 394
L + ++ L+ K +K+E+IE++K R + DA IR++ + KK+ +
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626
Query: 395 SRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREG-----------RGNESDY 443
+ + +L + AE Q + V + K + L+ R R N
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLL 1686
Query: 444 RKLEEMHQRFLVSERSKDDLQLRLTRAENRI--------------KQLETDSSEEISRYQ 489
+LEEM +ER++ + L A +R+ K+LE D ++ + +
Sbjct: 1687 EELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE 1746
Query: 490 EMIQKLQNVLESERE---NCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKIS 546
IQ+ +N E ++ + +++E+ K Q + L + ++L + + Q +
Sbjct: 1747 NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR------ 1800
Query: 547 TMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQK-------AANRWKEETKKLT 599
++ + +G + Q++++E N + EL + L +QK A++++ + K++T
Sbjct: 1801 -LDEAEQLALKGGKKQIQKLE----NRVRELENELDVEQKRGAEALKGAHKYERKVKEMT 1855
Query: 600 ESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKAN-------RLQ 652
AE N+ L Q+L+ +L+ KV ++ E +E+AN R+Q
Sbjct: 1856 YQAEEDHKNI--------LRLQDLVDKLQA---KVKSYKRQAEEAEEQANTQLSRCRRVQ 1904
Query: 653 RRLSQAEERAASASQQLSVITVQRRKAAS 681
L +A ERA A Q++ + + R S
Sbjct: 1905 HELEEAAERADIAESQVNKLRAKSRDVGS 1933
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/475 (18%), Positives = 191/475 (40%), Gaps = 51/475 (10%)
Query: 260 EKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKC 319
EK++ + E + L + ++ K+LE ++ +QE N L+ + + + + +C
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 320 NELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRT 379
L + + + + LEE S+ + +++ E+ +K + T
Sbjct: 910 EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVE 969
Query: 380 KKEVANTKKQCNI---------QISRLTEELSALQM-------ECAEKQGQIERVIKEKK 423
K++ A K N+ IS+LT+E +LQ + ++ ++ +IK
Sbjct: 970 KEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINA 1029
Query: 424 AVEEE-------LEKIYREGRGNESDYRKLE---EMHQRFLVS-ERSKDDLQLRLTRAEN 472
+E++ LE+ + E RKLE +M Q ++ E K ++ +L + E
Sbjct: 1030 KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEF 1089
Query: 473 RIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQ 522
+ QL+ +E I Q I++L+ +E+E + +QR L +E ++
Sbjct: 1090 ELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEE 1149
Query: 523 LR---KETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRH 579
+ +E +E KK + + M + E + +S+ EL
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE 1209
Query: 580 LLATQQKAANRWKEETKKLTESAEIRINNL------KSELSRQKLHTQELLSQLEMANEK 633
+ Q+ + ++E +L + +N+ KS + R ++ S+++ +E
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE- 1268
Query: 634 VAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLENI 688
+ +LI + + RLQ + + R +S +T + K A LE +
Sbjct: 1269 --QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT--KSKQALTQQLEEL 1319
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 101 bits (252), Expect = 2e-21
Identities = 135/668 (20%), Positives = 288/668 (43%), Gaps = 82/668 (12%)
Query: 64 DKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDI 123
++H E+ + +QK++ E+ E + ++E+ L ++ E + +
Sbjct: 420 EQHNREVQSLKEQHQKEISELN---ETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA 476
Query: 124 YADDETVRNLQEQLQLANQEKTQAV--ELWQTVSQELDRLHKLYQEHMT-----EAQIH- 175
+ E++R + E LQ E + E Q+ +H+L Q+ T +A +
Sbjct: 477 ILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLET 536
Query: 176 VFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKL------- 228
V Q + ++L Q+L +L T +N++ N +L +++++ ++++L K+
Sbjct: 537 VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK 596
Query: 229 ----------------------RQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSA 266
R+ +L L + KVE+ +L+ ++ + +
Sbjct: 597 DDFINKLKNSHEEMDNFHKKCEREERLILELG-KKVEQTIQYNSELEQKVNELTGGLEET 655
Query: 267 HGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENER 326
++ +D++L++L +K L V E L EN L + ++L +++
Sbjct: 656 LKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK 715
Query: 327 YEAIVRAR-----NSMQLL--EEANLQKSQALLEEKQKEEDIEK------MKETVSRFVQ 373
+ I++ +QL+ E+ NL K LLE +Q ++ K +KE S +
Sbjct: 716 EDVILKEHITQLEKKLQLMVEEQDNLNK---LLENEQVQKLFVKTQLYGFLKEMGSEVSE 772
Query: 374 DATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIK---EKKAVE-EEL 429
D+ +K+V N + ++++ EE L + EK ++E+ IK E+ V+ EEL
Sbjct: 773 DSE---EKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829
Query: 430 EKIYREGRGNESDYRK-LEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRY 488
+ + R+ + RK LEE+ + K+ LQ L +N ++ ++ + +
Sbjct: 830 KSLLRDYEQEKVLLRKELEEI-------QSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
Query: 489 QEMIQKL-QNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKIST 547
+E+ Q ++ + +E+E C + + LK E K+LR L + K VK
Sbjct: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Query: 548 MEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRIN 607
+ S+KE +++ E E + + L+A + A + + ++K T++ + +
Sbjct: 943 LS---SVKELEEKIENLEKECKEKEEKINKIKLVAVK---AKKELDSSRKETQTVKEELE 996
Query: 608 NLKSELSRQKLHTQELLSQLEMANEKVAENEKLILE---HQEKANRLQRRLSQAEERAAS 664
+L+SE + ++L+ E + E EK + +E+AN + R+ + +
Sbjct: 997 SLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRN 1056
Query: 665 ASQQLSVI 672
++ Q I
Sbjct: 1057 STLQCETI 1064
Score = 99.8 bits (247), Expect = 8e-21
Identities = 143/676 (21%), Positives = 297/676 (43%), Gaps = 88/676 (13%)
Query: 76 YYQKQVGEMKLQLENVIKENERLHSELKDAV----EKKLEAFPLGTEVGTDIYADDETVR 131
+ ++ V E LE+ +KE E HS LKD V KL+ + + + + E +
Sbjct: 325 FVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE 384
Query: 132 NLQEQLQLANQEKTQAVE------------LWQTVSQELDRLHKLYQEHMTEA----QIH 175
+L LA +E+ +E TV Q + L ++H E +
Sbjct: 385 FKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF 444
Query: 176 VFESQKQK-DQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQA--K 232
+ +S+K+K +F+ Q L +Q EN++ Q+ + I+E L+ +L ++ K
Sbjct: 445 LSDSEKEKLTLMFEIQGLKEQC----ENLQQEKQEAILNYESLREIMEILQTELGESAGK 500
Query: 233 LELRVAVAKVEELTNVTEDLQGQMKK--KEKD-VVSAHGREEASDRRLQQLQSSIKQLEI 289
+ K ++ ++V E LQ +++ EKD ++ R + + +L Q + +LE
Sbjct: 501 ISQEFESMKQQQASDVHE-LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELE- 558
Query: 290 RLCVTIQEANQLRTEN-THLEKQTRELQAKCNELENERYEAIVRARNSMQLLE--EANLQ 346
+QE N + + + + +EL+ K N L E+ + I + +NS + ++ +
Sbjct: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE 618
Query: 347 KSQALLEE--KQKEEDIEKMKETVSRFVQ-----DATIRTKKEVANTKKQCNIQISRLTE 399
+ + L+ E K+ E+ I+ E + + + T++ K + ++ +Q+ L+E
Sbjct: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
Query: 400 ELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERS 459
+ L E + ++ EKK + +LE ++ + + + ++ ++ +
Sbjct: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE-VFLSQKEDVILKEHITQLEKKLQLMVEE 737
Query: 460 KDDLQLRL-----------TRAENRIKQLETDSSEEISRYQEMIQKLQNVLES----ERE 504
+D+L L T+ +K++ ++ SE+ S ++++ LQ V ES E
Sbjct: 738 QDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSED-SEEKDVVNVLQAVGESLAKINEE 796
Query: 505 NCGLV---SEQRLKLQQENKQLRKET----ESLRKIALEAQKKAKVKISTMEHEFSIKER 557
C L E+ L+L++E K L++E+ E L+ + L ++ KV + E ++
Sbjct: 797 KCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSL-LRDYEQEKVLLRKELEEIQSEKE 855
Query: 558 GFEVQLREMEDSNRNSIVELRHLLA----------------TQQKAANRWKEETKKLTES 601
+ L EM+++N + +E ++LL ++K + E K L E
Sbjct: 856 ALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ 915
Query: 602 AEIRINN-----LKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS 656
E+R LK L++ + LS ++ EK+ EK E +EK N+++
Sbjct: 916 KELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAV 975
Query: 657 QAEERAASASQQLSVI 672
+A++ S+ ++ +
Sbjct: 976 KAKKELDSSRKETQTV 991
Score = 88.6 bits (218), Expect = 2e-17
Identities = 123/601 (20%), Positives = 253/601 (42%), Gaps = 109/601 (18%)
Query: 127 DETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQL 186
+E + ++ A +E + + QTV +EL+ L + + + ++ K+ L
Sbjct: 964 EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLL 1023
Query: 187 FDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELT 246
++++ ++QL V E + IE L ++LR + L+ + E+L
Sbjct: 1024 LEYEKQSEQLDVEKERANNFEHR-----------IEDLTRQLRNSTLQCETINSDNEDLL 1072
Query: 247 NVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENT 306
E LQ K E ++ + D+ L+ + +Q T+ E +L+ +
Sbjct: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQ-- 1130
Query: 307 HLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKS----------------QA 350
L+K+ ++LQ ELE + +A +M++ + L K Q
Sbjct: 1131 -LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Query: 351 LLEEKQKEE----DIEKMKETVSRFVQDAT------IRTKKEVANTKKQCNIQI---SRL 397
+ +KQK+E +I ++ +V ++ + T ++TKKE+A++K+ + + L
Sbjct: 1190 IKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1249
Query: 398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSE 457
EL A Q + + Q+ + EK + E L + E HQR L +
Sbjct: 1250 KGELEASQQQVEVYKIQLAEITSEKHKIHEHL--------------KTSAEQHQRTLSA- 1294
Query: 458 RSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQ 517
Q R+T + + + + + S ++ ++ NVL+ Q
Sbjct: 1295 -----YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK----------------Q 1333
Query: 518 QENKQLRK-ETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREME--DSNRNSI 574
Q+NK + + ETE A + ++ ++ I ++ + + ++ + E++ S +++
Sbjct: 1334 QKNKSMSQAETEG----AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL 1389
Query: 575 VELRHLLATQQKAANRWKEETKKLTESAEIR--INNLKSELSRQKLHTQELLSQLEMANE 632
+E RH N+ +ET +++ AE+R + +++SE K + +SQL NE
Sbjct: 1390 LE-RH---------NKMLQET--VSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNE 1437
Query: 633 KVAEN-----EKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLEN 687
+ + L EH++ LQ++LS+ E + QL R +S +L+N
Sbjct: 1438 VLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF----QLKNEPTTRSPVSSQQSLKN 1493
Query: 688 I 688
+
Sbjct: 1494 L 1494
Score = 83.2 bits (204), Expect = 7e-16
Identities = 115/584 (19%), Positives = 244/584 (41%), Gaps = 87/584 (14%)
Query: 96 ERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVS 155
E L E K+ EK + + + ++ + + + ++E+L+ EK Q + +
Sbjct: 954 ENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 156 QELDRLHKLYQEHMTEAQIHVFESQKQKDQLFD--FQQLTKQLHVTNENMEVTNQQF--- 210
Q + L E+ E Q + +K++ F+ + LT+QL + E N
Sbjct: 1014 QGAESYKNLLLEY--EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 211 ---LKTVTEQSVIIE-----------QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQM 256
++T+ + ++E + K+L KL+ + + N E+LQ Q+
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQL 1131
Query: 257 KKKEKDVVSAHGREEASDRRLQQLQSSIKQLEI----RLCVTIQEANQ-LRTENTHLEKQ 311
+K++K + E + QQ +++ +EI RL ++E NQ L +N +E
Sbjct: 1132 QKEKKQLQKTMQELELVKKDAQQ--TTLMNMEIADYERL---MKELNQKLTNKNNKIEDL 1186
Query: 312 TRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRF 371
+E++ + + E + E I ++S+Q EE N + Q L++ K++ D K ET
Sbjct: 1187 EQEIKIQKQKQETLQ-EEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD-SKQAET-DHL 1243
Query: 372 VQDATIRTKKEVANTKKQC-NIQISRLTEE-------------------------LSALQ 405
+ A+++ + E + + + IQ++ +T E ++ALQ
Sbjct: 1244 ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ 1303
Query: 406 MECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQL 465
EC + + V E ++ + + + ++ + + E Q E D L++
Sbjct: 1304 EECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI 1363
Query: 466 RLTRAEN----RIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENK 521
+L ++N + +L+T SE + + + LQ + E E + E+ +Q EN
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE----LREKLCSIQSENM 1419
Query: 522 QLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLL 581
++ E +S + + + F Q+R +++ +R ++ L+ L
Sbjct: 1420 MMKSEHTQ--------------TVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQL 1465
Query: 582 ATQQKAANRWKEE-TKKLTESAEIRINNLK----SELSRQKLHT 620
+ + + K E T + S++ + NL+ ++L +HT
Sbjct: 1466 SKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT 1509
Score = 73.6 bits (179), Expect = 6e-13
Identities = 136/667 (20%), Positives = 263/667 (39%), Gaps = 107/667 (16%)
Query: 83 EMKLQLENVIKENERLHSELKDAVEKKLEAFP---------------LGTEVGTDIYADD 127
E + Q ++ KEN ++ E++D+V K +A L E+
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 128 ETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE---HMTEAQIHVFESQKQKD 184
E NLQ+QL+ A + + E + + D + KL +E + + QKQ D
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 185 QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTE--------QSVIIEQLRKKLRQAKLELR 236
D ++ T + +E +Q + K + +++ E++++ + Q + +
Sbjct: 207 ATTDEKKET--VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAK 264
Query: 237 VAVAKVEELTNVTEDLQGQMKKKEKDVVSAHG---------------------------- 268
A++ +L + E+L Q + EK++ +
Sbjct: 265 EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENT 324
Query: 269 -REEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLE-----------KQTRELQ 316
E+ + +++ L+ ++K+LE + + E + LE + +L+
Sbjct: 325 FVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE 384
Query: 317 AKCNEL---ENERYEAIVRARNSMQLLE-------EANLQKSQALLEEKQKEEDIEKMKE 366
K NEL + E+ I + ++ + L E + ++ Q+L E+ QKE I ++ E
Sbjct: 385 FKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE--ISELNE 442
Query: 367 TVSRFVQDATIRTKKEVANTKKQC-NIQISR---------LTEELSALQMECAEKQGQIE 416
T + + E+ K+QC N+Q + L E + LQ E E G+I
Sbjct: 443 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 502
Query: 417 RVIKEKKAVE-EELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
+ + K + ++ ++ ++ R ++ L E R Q + EN IK
Sbjct: 503 QEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIK 562
Query: 476 QLETDSSE---EISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRK 532
L+ + +S+ M+++L+ + S E + +E K+ E +
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREER 622
Query: 533 IALEAQKKAKVKI---STMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAAN 589
+ LE KK + I S +E + + G E L+E +D N + + L Q K +
Sbjct: 623 LILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE-KDQNDQKLEK----LMVQMKVLS 677
Query: 590 RWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLE--MANEKVAENEK---LILEH 644
KE +S N L SE + + LSQ E + E + + EK L++E
Sbjct: 678 EDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737
Query: 645 QEKANRL 651
Q+ N+L
Sbjct: 738 QDNLNKL 744
Score = 65.5 bits (158), Expect = 2e-10
Identities = 96/500 (19%), Positives = 203/500 (40%), Gaps = 73/500 (14%)
Query: 70 LNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDET 129
+N ++ Y++ + E+ +L N + E L E+K +K+ E
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL--------------QEE 1203
Query: 130 VRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHM-TEAQIH-VFESQKQKDQLF 187
+ +LQ +Q ++ T+ +L +EL + +H+ +A + E+ +Q+ +++
Sbjct: 1204 ITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVY 1263
Query: 188 DFQ--QLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEEL 245
Q ++T + H +E+++ + +Q +T++ + L+++ R AK E ++ E
Sbjct: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY 1323
Query: 246 TNVTEDLQGQMKKKEKDVVSAHG---REEASDRRLQQLQSSIKQLEIRLCVTIQEANQLR 302
++ Q K K G E + + QL+ ++ + L + + E L+
Sbjct: 1324 KVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQ 1383
Query: 303 TE-NTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDI 361
+E +T LE+ + LQ ++ E E E + ++ +++ E Q +
Sbjct: 1384 SEHDTLLERHNKMLQETVSK-EAELREKLCSIQSENMMMKS----------EHTQTVSQL 1432
Query: 362 EKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKE 421
E + +D ++E T + Q+S++ +L L+ E +
Sbjct: 1433 TSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTR---------- 1482
Query: 422 KKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENR-IKQLETD 480
++ K RE R + L +MH +TR E ++ +T+
Sbjct: 1483 SPVSSQQSLKNLRERRNTD---LPLLDMH---------------TVTREEGEGMETTDTE 1524
Query: 481 SSEEISRYQEMIQKLQNVLESERE----NCGLVSEQRL-KLQQENKQ------LRKETES 529
S S Y + +++L N E++ E + E+ + KL K L +ETE+
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEA 1584
Query: 530 LRKIALEAQKKAKVKISTME 549
I +E K K +I +E
Sbjct: 1585 TNAILMEQIKLLKSEIRRLE 1604
Score = 63.2 bits (152), Expect = 8e-10
Identities = 92/435 (21%), Positives = 183/435 (42%), Gaps = 52/435 (11%)
Query: 306 THLEKQTRELQAK-CNELENERYEAIVRARNSMQLLEEANLQKSQALLEE----KQKEED 360
T LEK+ EL++K E + +A+ +++ L + Q+ +L +E KQ+ ED
Sbjct: 49 TELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVED 108
Query: 361 IEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAE---KQGQIER 417
+ ++ + I KE+ N K + S+ +E+ + LQ + E Q ++
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE 168
Query: 418 VIK-------EKKAVEEELEKI---------YREGRGNESDYRKLEEMHQRFLVSERSKD 461
+K K ++EE+EKI Y + + + + K E + Q + E +
Sbjct: 169 QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQ 228
Query: 462 DLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLK-LQQEN 520
Q + + + QL+ EE+ I+ E+E + E +K +
Sbjct: 229 HYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASE 288
Query: 521 KQLRK----ETESLRKIALEAQKKAKV-KISTMEHEF-----SIKERGFEVQLREMEDSN 570
K ++K E E+LRK A + ++ I E+ F + K + E L+E+E +
Sbjct: 289 KNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQH 348
Query: 571 ---RNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQL 627
++ + + +L + A K+E E E +IN L Q ++L S+L
Sbjct: 349 SILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSEL 408
Query: 628 EMANEKVA--------ENEKLILEHQEKANRLQRR-LSQAEERAASASQQLSVI-----T 673
N++ E + L +HQ++ + L LS +E+ + ++ +
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCEN 468
Query: 674 VQRRKAASLMNLENI 688
+Q+ K +++N E++
Sbjct: 469 LQQEKQEAILNYESL 483
Score = 59.3 bits (142), Expect = 1e-08
Identities = 106/508 (20%), Positives = 212/508 (41%), Gaps = 76/508 (14%)
Query: 31 SSVQKAVCQGEGDDTF--ENLVFDQSFLAPLVTEYDKHL---GELNGQLKYYQKQVGEMK 85
+S+Q +V Q E +T + LV + LA HL L G+L+ Q+QV K
Sbjct: 1205 TSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYK 1264
Query: 86 LQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKT 145
+QL + E ++H LK + E+ + A + V LQE+ + A E+
Sbjct: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRT----------LSAYQQRVTALQEECRAAKAEQA 1314
Query: 146 QAVELWQTVSQELDRLHKLYQEHMTEAQIH-VFESQKQKDQLFDFQQLTKQLHVTNENME 204
TV+ E + + ++H V + QK K Q T+ E++E
Sbjct: 1315 -------TVTSEFESY---------KVRVHNVLKQQKNKSM---SQAETEGAKQEREHLE 1355
Query: 205 VTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVV 264
++I+QL+ KL+ ++ L++ V++++ L + + L + K ++ V
Sbjct: 1356 --------------MLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETV 1401
Query: 265 SAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN 324
S +E +L +QS ++ T+ +QL ++N L R+ E
Sbjct: 1402 S---KEAELREKLCSIQSENMMMKSEHTQTV---SQLTSQNEVLRNSFRDQVRHLQEEHR 1455
Query: 325 ERYEAIVRARNSM--QLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKE 382
+ E + + + M QL + N +++ + +Q +++ + + T + T+ T++E
Sbjct: 1456 KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV-TREE 1514
Query: 383 VANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEEL-EKIYREGRGNES 441
+ +S + +L+ + ++E + + +EEL +K+ S
Sbjct: 1515 GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKL-------SS 1567
Query: 442 DYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVL-- 499
+ + ++ +E + L ++ ++ I++LE + E S ++ L+NVL
Sbjct: 1568 TTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAAN--LEYLKNVLLQ 1625
Query: 500 ------ESERENCGLVSEQRLKLQQENK 521
SERE V L+L E K
Sbjct: 1626 FIFLKPGSERERLLPVINTMLQLSPEEK 1653
Score = 50.1 bits (118), Expect = 7e-06
Identities = 78/340 (22%), Positives = 147/340 (43%), Gaps = 51/340 (15%)
Query: 354 EKQKEEDIEKMKETVSRFVQDATIRT---KKEVANTKKQCNIQ-----ISRLTEELSALQ 405
E +ED+ K + +Q A R +KE+ + + + I LTE L AL
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALL 82
Query: 406 MECAEKQGQI----ERVIKEKKAVEEELEKI---YREGRGNESDYRKLEEMHQRFLVSER 458
+E AE + Q + IK K+ VE+ + K+ ++E + +Y K E + L++ R
Sbjct: 83 LEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVR 142
Query: 459 S-----KDDLQLRLTRAENRIKQL------ETDSSEEISRYQEMIQKLQNVLESERENCG 507
S K +LQ +L A N +L + +S + + + QE I+K++ E
Sbjct: 143 SKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFE------- 195
Query: 508 LVSEQRLKLQQE---NKQLRKETESLRKIALEAQKKAKVK-ISTMEHEF----SIKERGF 559
EQ L LQ++ +KET + + +EA + K I++++ E +I +
Sbjct: 196 ---EQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEV 252
Query: 560 EVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQ--- 616
+ + ++E S + E+ L ++ + + K + + E + NL+ S
Sbjct: 253 KELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD 312
Query: 617 ----KLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQ 652
+ QE ++ NEKV E + E + + + L+
Sbjct: 313 NQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILK 352
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 101 bits (252), Expect = 2e-21
Identities = 147/670 (21%), Positives = 280/670 (41%), Gaps = 107/670 (15%)
Query: 57 APLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLG 116
A L + L EL GQ++ Q+ +++ ++ E + L + ++ K A L
Sbjct: 1202 ASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLC 1261
Query: 117 TEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHV 176
T ++ E L + QLAN Q +LW + L RL
Sbjct: 1262 TLYEERLH---EATAKLDKVTQLANDLAAQKTKLWSESGEFLRRL--------------- 1303
Query: 177 FESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELR 236
++K+ L + QL+++ +E Q K QS + L+K R L LR
Sbjct: 1304 ----EEKEALIN--QLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDL-LR 1356
Query: 237 VAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASD-RRLQQLQSSIKQLEIRLCVTI 295
+ EE V +L + K ++V + E + +R + L+ + K+L IRL
Sbjct: 1357 ---EQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAA 1413
Query: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355
+ N LE+ +LQ + + ++ + + R++ L++ LQ +AL + K
Sbjct: 1414 EAMGVANARNASLERARHQLQLELGDALSD----LGKVRSAAARLDQKQLQSGKALADWK 1469
Query: 356 QKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNI-------QISRLTEELSALQMEC 408
QK E+ + + + + VQ + K + NT ++ + + L EE+S L +
Sbjct: 1470 QKHEESQALLDASQKEVQALSTELLK-LKNTYEESIVGQETLRRENKNLQEEISNLTNQV 1528
Query: 409 AEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLT 468
E + + K KK +EEE ++ LEE +E QL L
Sbjct: 1529 REGTKNLTEMEKVKKLIEEEKTEVQVT----------LEETEGALERNESKILHFQLELL 1578
Query: 469 RAENRIKQLETDSSEEISRYQEM----IQKLQNVLESERENCGLVSEQRLKLQQE----- 519
A+ +++ ++ EEI ++ I LQ+ L+SE ++ V+ + K++++
Sbjct: 1579 EAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEME 1638
Query: 520 ------NKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNS 573
N+Q+ + T+SL ++ ++ + + + +KE +V + E +S S
Sbjct: 1639 LQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKE---QVAVAERRNSLLQS 1695
Query: 574 IVELRHLLATQQKAANRWKEETKKLTESAEIRIN--------------NLKSELSRQKLH 619
+E L Q + R EE +L E+ E RIN L+++++R +
Sbjct: 1696 ELEDLRSLQEQTERGRRLSEE--ELLEATE-RINLFYTQNTSLLSQKKKLEADVARMQKE 1752
Query: 620 TQELLSQLEMANEKVAE--------NEKL-----ILEHQEKANR--------LQRRLSQA 658
+E++ + + A EK + +E+L + H E+ LQ+RL++A
Sbjct: 1753 AEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEA 1812
Query: 659 EERAASASQQ 668
E+ A S++
Sbjct: 1813 EQMALMGSRK 1822
Score = 92.0 bits (227), Expect = 2e-18
Identities = 113/520 (21%), Positives = 235/520 (45%), Gaps = 83/520 (15%)
Query: 72 GQLKYYQKQVGEMKLQLENVIKENERLHSE---LKDAVEKKLEAFPLGTEV------GTD 122
G+++ ++ + +LQ + + ++ H E L DA +K+++A L TE+ +
Sbjct: 1445 GKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQA--LSTELLKLKNTYEE 1502
Query: 123 IYADDETVR----NLQEQLQ-LANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVF 177
ET+R NLQE++ L NQ + L E++++ KL +E TE Q+ +
Sbjct: 1503 SIVGQETLRRENKNLQEEISNLTNQVREGTKNL-----TEMEKVKKLIEEEKTEVQVTLE 1557
Query: 178 ESQ----KQKDQLFDFQ--------QLTKQLHVTNENMEVTN----------QQFLKTVT 215
E++ + + ++ FQ +L ++L +E +E Q L +
Sbjct: 1558 ETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEA 1617
Query: 216 EQSVIIEQLRKK----LRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDV-----VSA 266
+ + + +L+KK L + +L+L A +V E T LQ Q+K + + +++
Sbjct: 1618 KSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS 1677
Query: 267 HGREEAS--DRRLQQLQSSIKQL--------------EIRLCVTIQEANQLRTENTHLEK 310
+E+ + +RR LQS ++ L E L + N T+NT L
Sbjct: 1678 DLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Query: 311 QTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDI---EKMKET 367
Q ++L+A ++ E E + +N+ + ++A ++ + E K+K++ I E+ +E
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTREN 1797
Query: 368 VSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEE 427
+ + + D R + QI +L + L+ E +G+I R + ++
Sbjct: 1798 MEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELE---GELEGEIRRSAEAQRGARR 1854
Query: 428 ELEKIYREGRGN-ESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEIS 486
LE+ +E E D + L M + D LQL++ + +++ ET +++ +S
Sbjct: 1855 -LERCIKELTYQAEEDKKNLSRMQTQM-------DKLQLKVQNYKQQVEVAETQANQYLS 1906
Query: 487 RYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKE 526
+Y++ +L V E V++ ++K ++ K++++E
Sbjct: 1907 KYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Score = 91.3 bits (225), Expect = 3e-18
Identities = 103/455 (22%), Positives = 201/455 (44%), Gaps = 45/455 (9%)
Query: 223 QLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQS 282
QL+K L +++ + AK LT DL Q++ +++ + + + E + QL++
Sbjct: 870 QLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA 929
Query: 283 SIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYE---AIVRARNSMQL 339
+K+L R ++E ++ N+ L + R+L+ +C EL+ E + +V++ +
Sbjct: 930 RVKELSER----VEEEEEI---NSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRT 982
Query: 340 LEEANLQKSQALLEEKQ-KEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLT 398
E K + L EE + EDI K+ ++ VQ+A +T ++ ++ ++S L+
Sbjct: 983 TE----HKVKNLTEEVEFLNEDISKLNR-AAKVVQEAHQQTLDDLHMEEE----KLSSLS 1033
Query: 399 EELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSER 458
+ L+ + E +G +E+ K + E EL K+ + N LE QR L E
Sbjct: 1034 KANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLES-SQRHLAEEL 1092
Query: 459 SKDDLQLRL--TRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKL 516
K +L+L ++ EN K L + + Q I+ L+ LE+ER + +R L
Sbjct: 1093 RKKELELSQMNSKVENE-KGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADL 1151
Query: 517 QQENKQLRKETESL---RKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNS 573
Q+ L + E + LE KK + K + + FE ++ + +S
Sbjct: 1152 TQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADS 1211
Query: 574 IVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEK 633
+ EL + Q+ + +++ KS+L +L +LL+++E
Sbjct: 1212 LAELEGQVENLQQVKQKLEKD---------------KSDL---QLEVDDLLTRVEQMTRA 1253
Query: 634 VAENEKLILEHQEKANRLQRRLSQAEERAASASQQ 668
A EKL ++E+ + +L + + A + Q
Sbjct: 1254 KANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
Score = 88.2 bits (217), Expect = 2e-17
Identities = 126/666 (18%), Positives = 283/666 (42%), Gaps = 89/666 (13%)
Query: 59 LVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTE 118
L T Y++ L E +L + ++ Q +L SE + + + E L +
Sbjct: 1260 LCTLYEERLHEATAKLDKVTQLANDLAAQ-------KTKLWSESGEFLRRLEEKEALINQ 1312
Query: 119 VGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQE--------HMT 170
+ + + +L+ QL+ + ++ Q ++ D L + Y+E H T
Sbjct: 1313 LSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRT 1372
Query: 171 EAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQ 230
++++ Q + + Q T+ L + + + Q+ + + + L + Q
Sbjct: 1373 LSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQ 1432
Query: 231 AKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLE-- 288
+LEL A++ + ++ + L + + K + + E S L Q ++ L
Sbjct: 1433 LQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTE 1492
Query: 289 -IRLCVTIQEA----NQLRTENTHLEKQTRELQAKCNE--------------LENERYEA 329
++L T +E+ LR EN +L+++ L + E +E E+ E
Sbjct: 1493 LLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEV 1552
Query: 330 IVRA--------RNSMQLLE-EANLQKSQALLEEK--QKEEDIEKMKETVSRFVQDATIR 378
V RN ++L + L +++A LE K +K+E+IE + Q TI
Sbjct: 1553 QVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRK-----QQCTID 1607
Query: 379 TKKEVANTKKQCNIQISRLTEELSA------LQMECAEKQGQIERVIKEKKAVEEELEKI 432
+ + +++ + I+++RL +++ LQ+ CA +Q + K ++ +++ +
Sbjct: 1608 SLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQ--VSEATKSLGQLQIQIKDL 1665
Query: 433 YREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMI 492
+ + + ++ ++ V+ER LQ L + R Q +T+ +S +E++
Sbjct: 1666 QMQ---LDDSTQLNSDLKEQVAVAERRNSLLQSELE--DLRSLQEQTERGRRLSE-EELL 1719
Query: 493 QKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEF 552
+ + + +N L+S+++ KL+ + +++KE E + + A++KAK +
Sbjct: 1720 EATERINLFYTQNTSLLSQKK-KLEADVARMQKEAEEVVQECQNAEEKAK--------KA 1770
Query: 553 SIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSE 612
+I+ +L++ +D+ + HL T++ + K+L E+ ++ + + +
Sbjct: 1771 AIEAANLSEELKKKQDT-------IAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQ 1823
Query: 613 LSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVI 672
+ + + +EL +LE + A E Q A RL+R + + +A + LS +
Sbjct: 1824 IQKLESRVRELEGELEGEIRRSA-------EAQRGARRLERCIKELTYQAEEDKKNLSRM 1876
Query: 673 TVQRRK 678
Q K
Sbjct: 1877 QTQMDK 1882
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/612 (19%), Positives = 269/612 (43%), Gaps = 35/612 (5%)
Query: 73 QLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGT-------DIYA 125
QL+ Q+ + ++ Q E +IK +L + +K+ E+ E + +E+ + +
Sbjct: 902 QLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFE 961
Query: 126 DDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQ 185
+ + +L+ L + +EK + +++E++ L++ + A++ Q+ D
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 186 LFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEEL 245
L ++ L N +E + + ++ ++L + + L++ +E L
Sbjct: 1022 LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENL 1081
Query: 246 TNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTEN 305
+ L +++KKE ++ + + E + QLQ ++K+L+ ++ ++ RT
Sbjct: 1082 ESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTR 1141
Query: 306 THLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMK 365
+E++ +L +L NER E + +S+ LE Q+++ + EE
Sbjct: 1142 AKMERERADLTQDLADL-NERLEEV--GGSSLAQLEITKKQETKFQKLHRDMEEATLHF- 1197
Query: 366 ETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAV 425
ET S ++ + E+ + +L ++ S LQ+E + ++E++ + KA
Sbjct: 1198 ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTR-AKAN 1256
Query: 426 EEELEKIYREGRGNESDYRKLEEMHQ--RFLVSERSK-----DDLQLRLTRAENRIKQLE 478
E+L +Y E R +E+ KL+++ Q L ++++K + RL E I QL
Sbjct: 1257 AEKLCTLYEE-RLHEAT-AKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQL- 1313
Query: 479 TDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQ 538
S E S + I+ L+ LE E ++ ++ K Q++ LR++ E +++ E
Sbjct: 1314 ---SREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELH 1370
Query: 539 KKAKVKISTMEHEFSIKERGFEVQLRE-MEDSNRNSIVELRHLLATQQKAANRWKEETKK 597
+ K++ ++ +K +Q E +ED+ + + L+ A AN ++
Sbjct: 1371 RTLS-KVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQE-AAEAMGVANARNASLER 1428
Query: 598 LTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQ 657
++ + + S+L + + S ++K ++ K + + ++K Q L
Sbjct: 1429 ARHQLQLELGDALSDLGKVR-------SAAARLDQKQLQSGKALADWKQKHEESQALLDA 1481
Query: 658 AEERAASASQQL 669
+++ + S +L
Sbjct: 1482 SQKEVQALSTEL 1493
Score = 59.7 bits (143), Expect = 9e-09
Identities = 88/367 (23%), Positives = 155/367 (42%), Gaps = 74/367 (20%)
Query: 392 IQISRLTEELSALQMECAEKQGQIER------VIKEKKA--------------------- 424
++ S + EE++ L+ ECA+ Q +E+ +K K+
Sbjct: 852 VKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLA 911
Query: 425 -VEEELE-----KIYREGRGNESDYRKLEEMHQRFLVSERSK-------------DDLQL 465
VEE+ E KI E R E R EE ++ R + DDL+
Sbjct: 912 NVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLET 971
Query: 466 RLTRA-------ENRIKQLETD---SSEEISR-------YQEMIQKLQNVLESERENCGL 508
L ++ E+++K L + +E+IS+ QE Q+ + L E E
Sbjct: 972 MLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSS 1031
Query: 509 VSEQRLKLQQENKQLRKETESLRKIALEAQKK-------AKVKISTMEH-EFSIKERGFE 560
+S+ LKL+Q+ +L E RK + +++ K+ +ME+ E S + E
Sbjct: 1032 LSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEE 1091
Query: 561 VQLREMEDSNRNSIVE-LRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLH 619
++ +E+E S NS VE + L+A QK + + K L E E ++++ R++
Sbjct: 1092 LRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAE-RTTRAKMERERAD 1150
Query: 620 TQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKA 679
+ L+ L E+V + LE +K ++L + E A + S ++++R A
Sbjct: 1151 LTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSA-SLKKRHA 1209
Query: 680 ASLMNLE 686
SL LE
Sbjct: 1210 DSLAELE 1216
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 101 bits (252), Expect = 2e-21
Identities = 113/494 (22%), Positives = 226/494 (45%), Gaps = 54/494 (10%)
Query: 241 KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
KV+ L VT + +M+ KE ++ R++ ++ L++L+ QL + +QE Q
Sbjct: 840 KVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-LQEQLQ 897
Query: 301 LRTE-NTHLEKQTRELQAKCNELENERYEAIVRARNS----MQLLEEANLQKSQAL-LEE 354
TE E+ L AK ELE +E R QL E Q L LEE
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 355 KQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISR----LTEELSALQMECAE 410
+ +EE+ + K + + +A I+ ++ N ++S+ L E +S L AE
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 411 KQ-----------------GQIERVIKEKKAVEEELEKIYREGRGNESDYRKL-----EE 448
++ ++E +K+++ +ELEK+ R+ G+ SD+ + +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 449 MHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGL 508
+ + + + +++LQ L R ++ I Q + ++ ++I + I LQ L+SER
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 509 VSEQRLKLQQENKQLRKETE-SLRKIALEAQKKAK--VKISTMEHEFSIKERGFEVQLRE 565
+Q+ L +E + L+ E E +L A + + +AK +++ ++ + R E Q++E
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 566 MEDSNRNSIVELRHLLATQQKAA-----NRWKEETKKLTESAEIRI-NNLKSELSRQKLH 619
M + ++ EL L ++A N+ E + + E+R+ K E+ +K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-- 1254
Query: 620 TQELLSQLEMANEKVAENEKLILEHQEKANRLQRR-------LSQAEERAASASQQLSVI 672
++L +Q++ K ++ E+ E +K ++LQ L++AE +A ++ ++ +
Sbjct: 1255 -KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 673 TVQRRKAASLMNLE 686
+ Q + L+ E
Sbjct: 1314 SSQLQDTQELLQEE 1327
Score = 100 bits (248), Expect = 6e-21
Identities = 122/632 (19%), Positives = 284/632 (44%), Gaps = 58/632 (9%)
Query: 67 LGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYAD 126
L +L + Q Q+ E +N+ + L+ +L D+ +KKL+ F + + A
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS-KKKLQDF------ASTVEAL 1390
Query: 127 DETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEA--QIHVFESQKQKD 184
+E + Q++++ Q+ + + + + +RL + + + + Q + + ++K
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 185 QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR--KKLRQAKLEL----RVA 238
+ FD Q L ++ +++++ + ++ + +++ + R ++ +AK EL ++
Sbjct: 1451 RKFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 239 VAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEA 298
A++E+L + +D+ + + EK + A + +++++++ +++LE L T
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKS-------KRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 299 NQLRTENTHLEKQ-TRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQK 357
+L L+ Q R+LQA+ + E +R + + LE+ Q++ A +K+
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 358 EEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIER 417
E D++ ++ D+ I+ ++E ++ Q+ EL + E +
Sbjct: 1623 EGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 418 VIKEKKAVEEELEKIYR-----EGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAEN 472
K+ K++E +L ++ E ++D K EE+ + S ++ LQ R E
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEA 1736
Query: 473 RIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQ 522
RI QLE + EE + + + ++L N L +ER R +L+++NK+
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 523 LRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRN------SIVE 576
LR + L ++ + K K I+ +E + + E E + RE + + ++ + E
Sbjct: 1797 LRSK---LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 577 LRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAE 636
+ + ++K A ++KE+ +K R+ LK +L + +Q + + ++ E
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEK----GNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 637 NEKLILEHQEKANRLQRRLSQAEERAASASQQ 668
+ + N L+ +L + E + S++
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETSFVPSRR 1941
Score = 98.6 bits (244), Expect = 2e-20
Identities = 125/625 (20%), Positives = 260/625 (41%), Gaps = 58/625 (9%)
Query: 56 LAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL 115
L L + + + + Q+ Q Q+ E+K+QL +E + + L D + +K A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIH 175
E+ + + +LQE L + +A + + + +EL+ L K E ++
Sbjct: 1113 IREL-------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTAT 1164
Query: 176 VFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLEL 235
E + +++Q + L K L + E Q+ + + + +E+L ++L Q K
Sbjct: 1165 QQELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAK 1219
Query: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTI 295
+ L DL G+++ + +++ + ++Q+LQS E
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355
+ ++L+ E + E + K +L + + +++ +LL+E QK + +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 356 QKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQI 415
Q EE+ +++ + E K+ IS L +LS + + + +
Sbjct: 1340 QLEEERNSLQDQLD------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 416 ERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
E + + KK ++E+E + ++ + Y KLE+ R ++ DDL + L +
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVS 1444
Query: 476 QLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIAL 535
LE +K +L E+ +++R + + E ++ + SL + AL
Sbjct: 1445 NLEKKQ-----------RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-AL 1492
Query: 536 EAQKKAKVKISTMEHEFSIKERGFEVQLREMED--SNRNSIVELRHLLATQQKAANRWKE 593
E +AK ++ ER ++ EMED S+++ + + H L ++A E
Sbjct: 1493 EEALEAKEEL----------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 594 ETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQR 653
E K E E + + R +++ Q L Q E + A +E +++EK +LQR
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDE----QNEEKRRQLQR 1596
Query: 654 RLSQAEERAASASQQLSVITVQRRK 678
+L + E +Q ++ ++K
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKK 1621
Score = 94.4 bits (233), Expect = 3e-19
Identities = 148/651 (22%), Positives = 273/651 (41%), Gaps = 109/651 (16%)
Query: 83 EMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQ 142
E + + EN +KE E+ HS+L + EK L LQEQLQ +
Sbjct: 866 ERQQKAENELKELEQKHSQLTE--EKNL----------------------LQEQLQAETE 901
Query: 143 EKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNEN 202
+A E+ ++ + L ++ H EA++ E + Q QL +
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEIL--HEMEARLEEEEDRGQ------------QLQAERKK 947
Query: 203 MEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEK- 261
M QQ L + EQ E R+KL+ K+ + K+E+ V +D ++ K+ K
Sbjct: 948 MA---QQML-DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 262 ------DVVSAHGREEASDRRLQQL----QSSIKQLEIRLCVTIQEANQLRTENTHLE-- 309
D+ + EE + L +L +S I +LE+RL + +L LE
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 310 -----KQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKM 364
+Q +LQA+ EL+ + + + ++ L++ QK+ AL + ++ E I +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 365 KETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL------SALQMECAEKQGQIERV 418
+E + D+ + + K+ ++ L EL +A Q E K+ Q V
Sbjct: 1124 QEDL-----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 419 IKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRA--ENRIKQ 476
+ KKA++EE R +E+ +++ + H + V E ++ Q + +A + +
Sbjct: 1179 L--KKALDEET-------RSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 477 LETDSSEEISRYQEMIQ----------KLQNVLESERENCGLVSEQRLKLQQENKQLRKE 526
LE ++++ + + Q KL+ ++ + C R +L + +L+ E
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQK 586
ES+ + EA+ KA +K++ S + + + L+E N +LR L +
Sbjct: 1289 VESVTGMLNEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEK----VAENEKLIL 642
++ EE + ++ E I+ L +LS K Q+ S +E E E E L
Sbjct: 1348 LQDQLDEE-MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 643 EHQEKA----------NRLQRRLSQAEERAASASQQLSVITVQRRKAASLM 683
+++EKA NRLQ+ L + Q +S + ++RK L+
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Score = 91.7 bits (226), Expect = 2e-18
Identities = 143/713 (20%), Positives = 298/713 (41%), Gaps = 75/713 (10%)
Query: 35 KAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKE 94
K +G+ D E + Q+ +A L + K EL L ++ + L+ I+E
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-IRE 1115
Query: 95 NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN-LQEQL------QLANQEKTQA 147
E S+L++ ++ + A + D+ + E ++ L++ L Q ++ Q
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 148 VELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTN 207
V + + E R H+ + M Q H ++ +QL F++ L + +E N
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 208 QQF---LKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVV 264
L+ + + +E +KKL EL+ +K + +L ++ K + +V
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ---SKCSDGERARAELNDKVHKLQNEVE 1290
Query: 265 SAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN 324
S G ++ + +L + L +L T + + + ++ + R+L+ + N L++
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 325 ERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKK--- 381
+ E + +N + + N+Q S + + + +E ++E RF ++ T++
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 382 ------EVANTKKQCNIQISRLTEELS---ALQMECAEKQGQIERVIKEKKAVE----EE 428
++ TK + ++ L +L L +KQ + ++++ E+K + +E
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 429 LEKIYREGRGNE----SDYRKLEEMHQRFLVSER--------------SKDDLQLRLTRA 470
++ E R E S R LEE + ER SKDD+ +
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 471 ENRIKQLETDSSEEISRYQEMIQKLQNVLESE-RENCGLVS-----------------EQ 512
E + LET E ++ +E+ +LQ +++ R + + E+
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 513 RLKLQQENKQLRKETESLRK---IALEAQKKAKVKISTMEHEFSIKERGFE---VQLREM 566
R +LQ++ + E E RK +A A+KK + + +E + +G E QLR++
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 567 EDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQ 626
+ ++ EL A++ + KE KK +S E + L+ +L+ + ++ +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 627 LEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKA 679
E E++A + Q++ RL+ R++Q EE + ++ + RKA
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Score = 81.3 bits (199), Expect = 3e-15
Identities = 138/734 (18%), Positives = 295/734 (40%), Gaps = 86/734 (11%)
Query: 10 EQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGE 69
EQ L +M+ K +Q A+ + + + +N + + E + H+ +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK------IRELEGHISD 1122
Query: 70 LNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY----A 125
L L + + + Q ++ +E E L +EL+D ++ L + ++ A
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 126 DDETVRNLQEQLQLANQEKTQAVE-----------------------------------L 150
DE R+ + Q+Q Q+ QAVE +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 151 WQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFD--------FQQLTKQLHVTNEN 202
QE++ K + + E Q + ++ + +L D + +T L+ E
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-EG 1301
Query: 203 MEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTED-LQGQMKKK-- 259
+ + + +++ Q ++L ++ + KL + + ++EE N +D L +M+ K
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 260 -EKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAK 318
E+ + + + + S ++LQ S+++ LE +E L + +L+
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR 378
N L+ E + +V N QL+ +NL+K Q ++ EE K R +A R
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLV--SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 379 TKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRG 438
K+ A + + + EEL + ++E ++ K V + + ++ + R
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 439 NESDYRK----LEEMHQRFLVSERSKDDLQLRLTRAENRIK---QLETDSSEEISRY-QE 490
E+ + LEE+ +E +K L++ + + + + Q + +EE R Q
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 491 MIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESL---RKIALEAQKKAKVKIST 547
+ + + LE ER+ L + + KL+ + K L + +S R+ A++ +K + ++
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 548 MEHEFSIKERGFEVQLREMEDSNRNS------IVELRHLLATQQKA---ANRWKEETKKL 598
+ E + +++ + + +++L+ LA ++A A+ KEE +
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 599 TESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS-- 656
S+ N L+ E R + +L +LE + + + ++A +L L+
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 657 -QAEERAASASQQL 669
++ SA QQL
Sbjct: 1777 RSTAQKNESARQQL 1790
Score = 70.9 bits (172), Expect = 4e-12
Identities = 93/471 (19%), Positives = 206/471 (43%), Gaps = 40/471 (8%)
Query: 10 EQNRRLNEDFRRYQMESFSKYSSVQKAV-CQGEGDDTFENLVFDQSFLAPLVTEYDKHLG 68
++ R + R + ++ S ++++A+ + E + T + L + L + K++
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 69 ELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDE 128
EL + + Q+ EMK QLE +++ + + K +E ++A L + D+ A DE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDE 1585
Query: 129 TV----RNLQEQL-----QLANQEKTQAVELW--QTVSQELDRLHKLYQEHMTEAQIHVF 177
R LQ QL +L ++ K +A+ + + +L L + + +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 178 ESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV 237
+ +K + Q+ DFQ+ + + + + T ++ K + QL++ L A+ +
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 238 AVAKVEELT----------NVTED----LQGQMKKKEKDVVSAHGREEASDRRLQQLQSS 283
A + EEL N +D L+ ++ + E+++ G EA R+++
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 284 IKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELE---NERYEAIVRARNS--MQ 338
+QL L A + + LE+Q +EL++K +E+E ++++ + A + Q
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 339 LLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATI----RTKKEVANTK-KQCNIQ 393
L E+ + + K ++ +K+KE + + + + + + E N + KQ Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 394 ISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYRE-GRGNESDY 443
+ EE + + Q +++ + +A+ E+ + + RGNE+ +
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/204 (23%), Positives = 98/204 (48%), Gaps = 19/204 (9%)
Query: 484 EISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKV 543
+++R +E +Q ++ L+ +E + +L+Q++ QL +E L++ L+A+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYA 904
Query: 544 KISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAE 603
+ M + K++ E L EME + L A ++K A + + ++L E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE-- 962
Query: 604 IRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAA 663
E +RQKL +++ ++ ++ K E+E L+++ Q N+L + EER +
Sbjct: 963 --------EAARQKLQLEKVTAEAKI---KKLEDEILVMDDQN--NKLSKERKLLEERIS 1009
Query: 664 SASQQLSVITVQRRKAASLMNLEN 687
+ L+ + KA +L L+N
Sbjct: 1010 DLTTNLA---EEEEKAKNLTKLKN 1030
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 101 bits (252), Expect = 2e-21
Identities = 113/494 (22%), Positives = 226/494 (45%), Gaps = 54/494 (10%)
Query: 241 KVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQ 300
KV+ L VT + +M+ KE ++ R++ ++ L++L+ QL + +QE Q
Sbjct: 847 KVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-LQEQLQ 904
Query: 301 LRTE-NTHLEKQTRELQAKCNELENERYEAIVRARNS----MQLLEEANLQKSQAL-LEE 354
TE E+ L AK ELE +E R QL E Q L LEE
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 355 KQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISR----LTEELSALQMECAE 410
+ +EE+ + K + + +A I+ ++ N ++S+ L E +S L AE
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 411 KQ-----------------GQIERVIKEKKAVEEELEKIYREGRGNESDYRKL-----EE 448
++ ++E +K+++ +ELEK+ R+ G+ SD+ + +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 449 MHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGL 508
+ + + + +++LQ L R ++ I Q + ++ ++I + I LQ L+SER
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 509 VSEQRLKLQQENKQLRKETE-SLRKIALEAQKKAK--VKISTMEHEFSIKERGFEVQLRE 565
+Q+ L +E + L+ E E +L A + + +AK +++ ++ + R E Q++E
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 566 MEDSNRNSIVELRHLLATQQKAA-----NRWKEETKKLTESAEIRI-NNLKSELSRQKLH 619
M + ++ EL L ++A N+ E + + E+R+ K E+ +K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-- 1261
Query: 620 TQELLSQLEMANEKVAENEKLILEHQEKANRLQRR-------LSQAEERAASASQQLSVI 672
++L +Q++ K ++ E+ E +K ++LQ L++AE +A ++ ++ +
Sbjct: 1262 -KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 673 TVQRRKAASLMNLE 686
+ Q + L+ E
Sbjct: 1321 SSQLQDTQELLQEE 1334
Score = 100 bits (248), Expect = 6e-21
Identities = 122/632 (19%), Positives = 284/632 (44%), Gaps = 58/632 (9%)
Query: 67 LGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYAD 126
L +L + Q Q+ E +N+ + L+ +L D+ +KKL+ F + + A
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS-KKKLQDF------ASTVEAL 1397
Query: 127 DETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEA--QIHVFESQKQKD 184
+E + Q++++ Q+ + + + + +RL + + + + Q + + ++K
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 185 QLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLR--KKLRQAKLEL----RVA 238
+ FD Q L ++ +++++ + ++ + +++ + R ++ +AK EL ++
Sbjct: 1458 RKFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 239 VAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEA 298
A++E+L + +D+ + + EK + A + +++++++ +++LE L T
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKS-------KRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 299 NQLRTENTHLEKQ-TRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQK 357
+L L+ Q R+LQA+ + E +R + + LE+ Q++ A +K+
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 358 EEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIER 417
E D++ ++ D+ I+ ++E ++ Q+ EL + E +
Sbjct: 1630 EGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 418 VIKEKKAVEEELEKIYR-----EGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAEN 472
K+ K++E +L ++ E ++D K EE+ + S ++ LQ R E
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEA 1743
Query: 473 RIKQLETDSSEE----------ISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQ 522
RI QLE + EE + + + ++L N L +ER R +L+++NK+
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 523 LRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRN------SIVE 576
LR + L ++ + K K I+ +E + + E E + RE + + ++ + E
Sbjct: 1804 LRSK---LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 577 LRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAE 636
+ + ++K A ++KE+ +K R+ LK +L + +Q + + ++ E
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEK----GNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 637 NEKLILEHQEKANRLQRRLSQAEERAASASQQ 668
+ + N L+ +L + E + S++
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETSFVPSRR 1948
Score = 98.6 bits (244), Expect = 2e-20
Identities = 125/625 (20%), Positives = 260/625 (41%), Gaps = 58/625 (9%)
Query: 56 LAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL 115
L L + + + + Q+ Q Q+ E+K+QL +E + + L D + +K A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIH 175
E+ + + +LQE L + +A + + + +EL+ L K E ++
Sbjct: 1120 IREL-------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL-KTELEDTLDSTAT 1171
Query: 176 VFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLEL 235
E + +++Q + L K L + E Q+ + + + +E+L ++L Q K
Sbjct: 1172 QQELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAK 1226
Query: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTI 295
+ L DL G+++ + +++ + ++Q+LQS E
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355
+ ++L+ E + E + K +L + + +++ +LL+E QK + +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 356 QKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQI 415
Q EE+ +++ + E K+ IS L +LS + + + +
Sbjct: 1347 QLEEERNSLQDQLD------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 416 ERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIK 475
E + + KK ++E+E + ++ + Y KLE+ R ++ DDL + L +
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVS 1451
Query: 476 QLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIAL 535
LE +K +L E+ +++R + + E ++ + SL + AL
Sbjct: 1452 NLEKKQ-----------RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-AL 1499
Query: 536 EAQKKAKVKISTMEHEFSIKERGFEVQLREMED--SNRNSIVELRHLLATQQKAANRWKE 593
E +AK ++ ER ++ EMED S+++ + + H L ++A E
Sbjct: 1500 EEALEAKEEL----------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 594 ETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQR 653
E K E E + + R +++ Q L Q E + A +E +++EK +LQR
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDE----QNEEKRRQLQR 1603
Query: 654 RLSQAEERAASASQQLSVITVQRRK 678
+L + E +Q ++ ++K
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKK 1628
Score = 94.4 bits (233), Expect = 3e-19
Identities = 148/651 (22%), Positives = 273/651 (41%), Gaps = 109/651 (16%)
Query: 83 EMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQ 142
E + + EN +KE E+ HS+L + EK L LQEQLQ +
Sbjct: 873 ERQQKAENELKELEQKHSQLTE--EKNL----------------------LQEQLQAETE 908
Query: 143 EKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNEN 202
+A E+ ++ + L ++ H EA++ E + Q QL +
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEIL--HEMEARLEEEEDRGQ------------QLQAERKK 954
Query: 203 MEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEK- 261
M QQ L + EQ E R+KL+ K+ + K+E+ V +D ++ K+ K
Sbjct: 955 MA---QQML-DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Query: 262 ------DVVSAHGREEASDRRLQQL----QSSIKQLEIRLCVTIQEANQLRTENTHLE-- 309
D+ + EE + L +L +S I +LE+RL + +L LE
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 310 -----KQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKM 364
+Q +LQA+ EL+ + + + ++ L++ QK+ AL + ++ E I +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 365 KETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEEL------SALQMECAEKQGQIERV 418
+E + D+ + + K+ ++ L EL +A Q E K+ Q V
Sbjct: 1131 QEDL-----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 419 IKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRA--ENRIKQ 476
+ KKA++EE R +E+ +++ + H + V E ++ Q + +A + +
Sbjct: 1186 L--KKALDEET-------RSHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 477 LETDSSEEISRYQEMIQ----------KLQNVLESERENCGLVSEQRLKLQQENKQLRKE 526
LE ++++ + + Q KL+ ++ + C R +L + +L+ E
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 527 TESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQK 586
ES+ + EA+ KA +K++ S + + + L+E N +LR L +
Sbjct: 1296 VESVTGMLNEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 587 AANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEK----VAENEKLIL 642
++ EE + ++ E I+ L +LS K Q+ S +E E E E L
Sbjct: 1355 LQDQLDEE-MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 643 EHQEKA----------NRLQRRLSQAEERAASASQQLSVITVQRRKAASLM 683
+++EKA NRLQ+ L + Q +S + ++RK L+
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Score = 91.7 bits (226), Expect = 2e-18
Identities = 143/713 (20%), Positives = 298/713 (41%), Gaps = 75/713 (10%)
Query: 35 KAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKE 94
K +G+ D E + Q+ +A L + K EL L ++ + L+ I+E
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-IRE 1122
Query: 95 NERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRN-LQEQL------QLANQEKTQA 147
E S+L++ ++ + A + D+ + E ++ L++ L Q ++ Q
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 148 VELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTN 207
V + + E R H+ + M Q H ++ +QL F++ L + +E N
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 208 QQF---LKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVV 264
L+ + + +E +KKL EL+ +K + +L ++ K + +V
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ---SKCSDGERARAELNDKVHKLQNEVE 1297
Query: 265 SAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELEN 324
S G ++ + +L + L +L T + + + ++ + R+L+ + N L++
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 325 ERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKK--- 381
+ E + +N + + N+Q S + + + +E ++E RF ++ T++
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 382 ------EVANTKKQCNIQISRLTEELS---ALQMECAEKQGQIERVIKEKKAVE----EE 428
++ TK + ++ L +L L +KQ + ++++ E+K + +E
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 429 LEKIYREGRGNE----SDYRKLEEMHQRFLVSER--------------SKDDLQLRLTRA 470
++ E R E S R LEE + ER SKDD+ +
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 471 ENRIKQLETDSSEEISRYQEMIQKLQNVLESE-RENCGLVS-----------------EQ 512
E + LET E ++ +E+ +LQ +++ R + + E+
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 513 RLKLQQENKQLRKETESLRK---IALEAQKKAKVKISTMEHEFSIKERGFE---VQLREM 566
R +LQ++ + E E RK +A A+KK + + +E + +G E QLR++
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 567 EDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQ 626
+ ++ EL A++ + KE KK +S E + L+ +L+ + ++ +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 627 LEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKA 679
E E++A + Q++ RL+ R++Q EE + ++ + RKA
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Score = 81.3 bits (199), Expect = 3e-15
Identities = 138/734 (18%), Positives = 295/734 (40%), Gaps = 86/734 (11%)
Query: 10 EQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGE 69
EQ L +M+ K +Q A+ + + + +N + + E + H+ +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK------IRELEGHISD 1129
Query: 70 LNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIY----A 125
L L + + + Q ++ +E E L +EL+D ++ L + ++ A
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 126 DDETVRNLQEQLQLANQEKTQAVE-----------------------------------L 150
DE R+ + Q+Q Q+ QAVE +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 151 WQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFD--------FQQLTKQLHVTNEN 202
QE++ K + + E Q + ++ + +L D + +T L+ E
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-EG 1308
Query: 203 MEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTED-LQGQMKKK-- 259
+ + + +++ Q ++L ++ + KL + + ++EE N +D L +M+ K
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 260 -EKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAK 318
E+ + + + + S ++LQ S+++ LE +E L + +L+
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 319 CNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIR 378
N L+ E + +V N QL+ +NL+K Q ++ EE K R +A R
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLV--SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 379 TKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRG 438
K+ A + + + EEL + ++E ++ K V + + ++ + R
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 439 NESDYRK----LEEMHQRFLVSERSKDDLQLRLTRAENRIK---QLETDSSEEISRY-QE 490
E+ + LEE+ +E +K L++ + + + + Q + +EE R Q
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 491 MIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESL---RKIALEAQKKAKVKIST 547
+ + + LE ER+ L + + KL+ + K L + +S R+ A++ +K + ++
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 548 MEHEFSIKERGFEVQLREMEDSNRNS------IVELRHLLATQQKA---ANRWKEETKKL 598
+ E + +++ + + +++L+ LA ++A A+ KEE +
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 599 TESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLS-- 656
S+ N L+ E R + +L +LE + + + ++A +L L+
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 657 -QAEERAASASQQL 669
++ SA QQL
Sbjct: 1784 RSTAQKNESARQQL 1797
Score = 70.9 bits (172), Expect = 4e-12
Identities = 93/471 (19%), Positives = 206/471 (43%), Gaps = 40/471 (8%)
Query: 10 EQNRRLNEDFRRYQMESFSKYSSVQKAV-CQGEGDDTFENLVFDQSFLAPLVTEYDKHLG 68
++ R + R + ++ S ++++A+ + E + T + L + L + K++
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 69 ELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDE 128
EL + + Q+ EMK QLE +++ + + K +E ++A L + D+ A DE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDE 1592
Query: 129 TV----RNLQEQL-----QLANQEKTQAVELW--QTVSQELDRLHKLYQEHMTEAQIHVF 177
R LQ QL +L ++ K +A+ + + +L L + + +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 178 ESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRV 237
+ +K + Q+ DFQ+ + + + + T ++ K + QL++ L A+ +
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 238 AVAKVEELT----------NVTED----LQGQMKKKEKDVVSAHGREEASDRRLQQLQSS 283
A + EEL N +D L+ ++ + E+++ G EA R+++
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 284 IKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELE---NERYEAIVRARNS--MQ 338
+QL L A + + LE+Q +EL++K +E+E ++++ + A + Q
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 339 LLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATI----RTKKEVANTK-KQCNIQ 393
L E+ + + K ++ +K+KE + + + + + + E N + KQ Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 394 ISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYRE-GRGNESDY 443
+ EE + + Q +++ + +A+ E+ + + RGNE+ +
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/204 (23%), Positives = 98/204 (48%), Gaps = 19/204 (9%)
Query: 484 EISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKV 543
+++R +E +Q ++ L+ +E + +L+Q++ QL +E L++ L+A+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYA 911
Query: 544 KISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAE 603
+ M + K++ E L EME + L A ++K A + + ++L E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE-- 969
Query: 604 IRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAA 663
E +RQKL +++ ++ ++ K E+E L+++ Q N+L + EER +
Sbjct: 970 --------EAARQKLQLEKVTAEAKI---KKLEDEILVMDDQN--NKLSKERKLLEERIS 1016
Query: 664 SASQQLSVITVQRRKAASLMNLEN 687
+ L+ + KA +L L+N
Sbjct: 1017 DLTTNLA---EEEEKAKNLTKLKN 1037
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,900,587
Number of Sequences: 37866
Number of extensions: 927231
Number of successful extensions: 17865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 458
Number of HSP's successfully gapped in prelim test: 1220
Number of HSP's that attempted gapping in prelim test: 5900
Number of HSP's gapped (non-prelim): 5714
length of query: 688
length of database: 18,247,518
effective HSP length: 109
effective length of query: 579
effective length of database: 14,120,124
effective search space: 8175551796
effective search space used: 8175551796
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.