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Search of human proteins with 153791330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
(716 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 1428 0.0
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 782 0.0
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 782 0.0
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 782 0.0
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 652 0.0
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 652 0.0
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 167 3e-41
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 164 3e-40
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 157 2e-38
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 153 6e-37
gi|51317373 netrin-G1 ligand [Homo sapiens] 136 6e-32
gi|198041768 synleurin [Homo sapiens] 135 1e-31
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 130 6e-30
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 124 4e-28
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 124 4e-28
gi|31542244 leucine rich repeat and fibronectin type III domain ... 122 9e-28
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 122 9e-28
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 120 3e-27
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 120 6e-27
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 118 2e-26
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 117 5e-26
gi|109150416 peroxidasin [Homo sapiens] 115 1e-25
gi|194440719 chondroadherin-like [Homo sapiens] 114 3e-25
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 112 9e-25
gi|188528675 slit homolog 1 [Homo sapiens] 112 1e-24
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 110 6e-24
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 107 3e-23
gi|225579152 insulin-like growth factor binding protein, acid la... 105 1e-22
gi|4826772 insulin-like growth factor binding protein, acid labi... 105 1e-22
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 105 1e-22
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 1428 bits (3697), Expect = 0.0
Identities = 716/716 (100%), Positives = 716/716 (100%)
Query: 1 MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCND 60
MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCND
Sbjct: 1 MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCND 60
Query: 61 LRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQ 120
LRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQ
Sbjct: 61 LRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQ 120
Query: 121 LTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLK 180
LTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLK
Sbjct: 121 LTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLK 180
Query: 181 VIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDS 240
VIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDS
Sbjct: 181 VIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDS 240
Query: 241 LESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGEL 300
LESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGEL
Sbjct: 241 LESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGEL 300
Query: 301 VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESL 360
VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESL
Sbjct: 301 VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESL 360
Query: 361 PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSE 420
PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSE
Sbjct: 361 PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSE 420
Query: 421 QCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSS 480
QCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSS
Sbjct: 421 QCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSS 480
Query: 481 EGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSIL 540
EGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSIL
Sbjct: 481 EGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSIL 540
Query: 541 VSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSN 600
VSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSN
Sbjct: 541 VSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSN 600
Query: 601 IHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKN 660
IHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKN
Sbjct: 601 IHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKN 660
Query: 661 YHHSLKKYMQKTSSIPLNELYPPLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW 716
YHHSLKKYMQKTSSIPLNELYPPLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW
Sbjct: 661 YHHSLKKYMQKTSSIPLNELYPPLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW 716
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 782 bits (2020), Expect = 0.0
Identities = 379/683 (55%), Positives = 508/683 (74%), Gaps = 3/683 (0%)
Query: 13 LVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSS 72
++LGL +T+L ++ + +CP+LC CEIRPWFTP+S Y EA+TVDCNDL L P+ L +
Sbjct: 10 VLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPA 69
Query: 73 DTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
+TQ+LLLQ+NNIAK NLT LD SQNN +++ + + + QL +++LEEN++T
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192
E+ + CL +LSNLQELYINHN +STIS AF GL NLLRLHLNSN+L++I+S+WFD+ PN
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
LEILMIGENP+I I DMNFKPL NLRSLV+AG+ LT+IP NALVGL++LES+SFYDN+L+
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 253 KVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLP 312
KVP +ALQKV NLKFLDLNKNPI++I+ GDF NML LKELGINNM EL+S+D A+DNLP
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 313 ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNP 372
+L K+EATNNP+LSYIH AF +P LESLMLN+NAL+A+Y T+ESLPNL+EISIHSNP
Sbjct: 310 DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNP 369
Query: 373 LRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFP 432
+RCDCVI W+N NKTNIRFMEP S+FC PPE++G V++V +D E CLP+I+ +SFP
Sbjct: 370 IRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFP 429
Query: 433 NRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIE 492
+ LNV+ G+ V CRA AEP+PEIYW+TP G K+ TL+DK+ + SEGTL+I+ + +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 493 DSGRYTCVAQNVQGADTRVATIKVNGTL-LDGTQVLKIYVKQTESHSILVSWKVNSNVMT 551
+ G YTC+A N+ GAD + IKV+G+ D L I ++ +++S+LVSWK +S ++
Sbjct: 490 EGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILK 549
Query: 552 SNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVN 611
S++KW +A +K +N H +AR+P DV YNLTHL PST+Y++C+ + I+Q+ +K CVN
Sbjct: 550 SSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVN 608
Query: 612 VTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQK 671
VTTK ++ +T L A +G + +I + + + H ++ Y+QK
Sbjct: 609 VTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQK 668
Query: 672 TSSIPLNELYPPLINLWEGDSEK 694
+ L ELYPPLINLWE EK
Sbjct: 669 -PTFALGELYPPLINLWEAGKEK 690
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 782 bits (2020), Expect = 0.0
Identities = 379/683 (55%), Positives = 508/683 (74%), Gaps = 3/683 (0%)
Query: 13 LVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSS 72
++LGL +T+L ++ + +CP+LC CEIRPWFTP+S Y EA+TVDCNDL L P+ L +
Sbjct: 10 VLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPA 69
Query: 73 DTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
+TQ+LLLQ+NNIAK NLT LD SQNN +++ + + + QL +++LEEN++T
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192
E+ + CL +LSNLQELYINHN +STIS AF GL NLLRLHLNSN+L++I+S+WFD+ PN
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
LEILMIGENP+I I DMNFKPL NLRSLV+AG+ LT+IP NALVGL++LES+SFYDN+L+
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 253 KVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLP 312
KVP +ALQKV NLKFLDLNKNPI++I+ GDF NML LKELGINNM EL+S+D A+DNLP
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 313 ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNP 372
+L K+EATNNP+LSYIH AF +P LESLMLN+NAL+A+Y T+ESLPNL+EISIHSNP
Sbjct: 310 DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNP 369
Query: 373 LRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFP 432
+RCDCVI W+N NKTNIRFMEP S+FC PPE++G V++V +D E CLP+I+ +SFP
Sbjct: 370 IRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFP 429
Query: 433 NRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIE 492
+ LNV+ G+ V CRA AEP+PEIYW+TP G K+ TL+DK+ + SEGTL+I+ + +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 493 DSGRYTCVAQNVQGADTRVATIKVNGTL-LDGTQVLKIYVKQTESHSILVSWKVNSNVMT 551
+ G YTC+A N+ GAD + IKV+G+ D L I ++ +++S+LVSWK +S ++
Sbjct: 490 EGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILK 549
Query: 552 SNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVN 611
S++KW +A +K +N H +AR+P DV YNLTHL PST+Y++C+ + I+Q+ +K CVN
Sbjct: 550 SSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVN 608
Query: 612 VTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQK 671
VTTK ++ +T L A +G + +I + + + H ++ Y+QK
Sbjct: 609 VTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQK 668
Query: 672 TSSIPLNELYPPLINLWEGDSEK 694
+ L ELYPPLINLWE EK
Sbjct: 669 -PTFALGELYPPLINLWEAGKEK 690
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 782 bits (2020), Expect = 0.0
Identities = 379/683 (55%), Positives = 508/683 (74%), Gaps = 3/683 (0%)
Query: 13 LVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSS 72
++LGL +T+L ++ + +CP+LC CEIRPWFTP+S Y EA+TVDCNDL L P+ L +
Sbjct: 10 VLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPA 69
Query: 73 DTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
+TQ+LLLQ+NNIAK NLT LD SQNN +++ + + + QL +++LEEN++T
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192
E+ + CL +LSNLQELYINHN +STIS AF GL NLLRLHLNSN+L++I+S+WFD+ PN
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
LEILMIGENP+I I DMNFKPL NLRSLV+AG+ LT+IP NALVGL++LES+SFYDN+L+
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 253 KVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLP 312
KVP +ALQKV NLKFLDLNKNPI++I+ GDF NML LKELGINNM EL+S+D A+DNLP
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 313 ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNP 372
+L K+EATNNP+LSYIH AF +P LESLMLN+NAL+A+Y T+ESLPNL+EISIHSNP
Sbjct: 310 DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNP 369
Query: 373 LRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFP 432
+RCDCVI W+N NKTNIRFMEP S+FC PPE++G V++V +D E CLP+I+ +SFP
Sbjct: 370 IRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFP 429
Query: 433 NRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIE 492
+ LNV+ G+ V CRA AEP+PEIYW+TP G K+ TL+DK+ + SEGTL+I+ + +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 493 DSGRYTCVAQNVQGADTRVATIKVNGTL-LDGTQVLKIYVKQTESHSILVSWKVNSNVMT 551
+ G YTC+A N+ GAD + IKV+G+ D L I ++ +++S+LVSWK +S ++
Sbjct: 490 EGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILK 549
Query: 552 SNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVN 611
S++KW +A +K +N H +AR+P DV YNLTHL PST+Y++C+ + I+Q+ +K CVN
Sbjct: 550 SSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVN 608
Query: 612 VTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQK 671
VTTK ++ +T L A +G + +I + + + H ++ Y+QK
Sbjct: 609 VTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQK 668
Query: 672 TSSIPLNELYPPLINLWEGDSEK 694
+ L ELYPPLINLWE EK
Sbjct: 669 -PTFALGELYPPLINLWEAGKEK 690
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 652 bits (1681), Expect = 0.0
Identities = 328/591 (55%), Positives = 425/591 (71%), Gaps = 6/591 (1%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-VDE 90
CP C C+IRPW+TP+S+YREATTVDCNDL LT +P L + TQ LLLQSN+I + E
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 91 LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150
L L NLTELD SQN+F++ ++ L QL +LHLEENQ+T + D+ L++LQELY+
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 151 NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMN 210
NHNQ+ I+ AF+GL NLLRLHLNSN L+ IDSRWF+ PNLEILMIG N V ILDMN
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 211 FKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270
F+PLANLRSLVLAGM L +I AL GL SLESLSFYDN+L +VP+ AL++VP LKFLDL
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
NKNP+ ++ GDF NML LKELG+NNM ELVS+D++AL NLPELTKL+ TNNP+LS+IH
Sbjct: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
Query: 331 LAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIR 390
AF +P +E+LMLNNNAL+A++Q+TVESLPNL+E+ +H NP+RCDCVI W N+ T +R
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVR 388
Query: 391 FMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM 450
F+EP S CA PP+ + V+EV ++ ++ CLP+IS SFP L V G ++ L CRA+
Sbjct: 389 FIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRAL 448
Query: 451 AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTR 510
AEPEPEIYWVTP G ++T +Y++ EGTLE+ + E++G YTCVAQN+ GADT+
Sbjct: 449 AEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTK 508
Query: 511 VATIKVNGTLL----DGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP 566
++ V LL D Q L++ V++T + IL+SW N +++NL WSSA+ +
Sbjct: 509 TVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSAS-SLRGQ 567
Query: 567 HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNA 617
T AR+P H YN+T L +T+Y CL V+ TQ +CV TK A
Sbjct: 568 GATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEA 618
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 652 bits (1681), Expect = 0.0
Identities = 328/591 (55%), Positives = 425/591 (71%), Gaps = 6/591 (1%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-VDE 90
CP C C+IRPW+TP+S+YREATTVDCNDL LT +P L + TQ LLLQSN+I + E
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 91 LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150
L L NLTELD SQN+F++ ++ L QL +LHLEENQ+T + D+ L++LQELY+
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 151 NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMN 210
NHNQ+ I+ AF+GL NLLRLHLNSN L+ IDSRWF+ PNLEILMIG N V ILDMN
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 211 FKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270
F+PLANLRSLVLAGM L +I AL GL SLESLSFYDN+L +VP+ AL++VP LKFLDL
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
NKNP+ ++ GDF NML LKELG+NNM ELVS+D++AL NLPELTKL+ TNNP+LS+IH
Sbjct: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328
Query: 331 LAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIR 390
AF +P +E+LMLNNNAL+A++Q+TVESLPNL+E+ +H NP+RCDCVI W N+ T +R
Sbjct: 329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVR 388
Query: 391 FMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM 450
F+EP S CA PP+ + V+EV ++ ++ CLP+IS SFP L V G ++ L CRA+
Sbjct: 389 FIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRAL 448
Query: 451 AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTR 510
AEPEPEIYWVTP G ++T +Y++ EGTLE+ + E++G YTCVAQN+ GADT+
Sbjct: 449 AEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTK 508
Query: 511 VATIKVNGTLL----DGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP 566
++ V LL D Q L++ V++T + IL+SW N +++NL WSSA+ +
Sbjct: 509 TVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSAS-SLRGQ 567
Query: 567 HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNA 617
T AR+P H YN+T L +T+Y CL V+ TQ +CV TK A
Sbjct: 568 GATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEA 618
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 167 bits (423), Expect = 3e-41
Identities = 151/579 (26%), Positives = 244/579 (42%), Gaps = 76/579 (13%)
Query: 8 IAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIP 67
I+ Q LGL + + S CP C C + +V C+ RL IP
Sbjct: 6 ISCWQPFLGLAVVLIFMGSTIG--CPARCECSA-----------QNKSVSCHRRRLIAIP 52
Query: 68 SNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLE 127
+ +T++L D S+N ++ + L + L
Sbjct: 53 EGIPIETKIL-----------------------DLSKNRLKSVNPEEFISYPLLEEIDLS 89
Query: 128 ENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWF 187
+N I + +L NL+ L + N++ + F GL NL +L ++ NK+ ++ F
Sbjct: 90 DNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMF 149
Query: 188 DSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFY 247
NL+ L +G+N ++ I F L +L L L LT +P AL L SL SL
Sbjct: 150 QDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLK 209
Query: 248 DNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYA 307
+ +P A +++ +LK L+++ P+ + + L L L + N L +V A
Sbjct: 210 HLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNT-NLSTVPFLA 268
Query: 308 LDNLPELTKLEATNNP-----------------------KLSYIHRLAFRSVPALESLML 344
+L LT L + NP +L I +F+ + L L +
Sbjct: 269 FKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNV 328
Query: 345 NNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRF--MEPLSMFCAMP 402
+ N L + + S L +SI++NPL CDC + WI + ++F +P+ CA P
Sbjct: 329 SQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM---CAGP 385
Query: 403 PEYKGHQVKEVLIQDSS--EQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWV 460
+ K+ S C + L VD G TV L+C A +P+P I WV
Sbjct: 386 DTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWV 445
Query: 461 TPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTL 520
TP IT ++ + + + +GTLEI Q +DSG Y C+A N G DT A++ V G
Sbjct: 446 TPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFA 504
Query: 521 LDGTQVLKIYVKQTESH----SILVSWKVNSNVMTSNLK 555
D +Y +T + + +S N+N + +LK
Sbjct: 505 SDRF----LYANRTPMYMTDSNDTISNGTNANTFSLDLK 539
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 164 bits (415), Expect = 3e-40
Identities = 142/530 (26%), Positives = 220/530 (41%), Gaps = 66/530 (12%)
Query: 14 VLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSD 73
VL L + L + CP C C + + V C RLT +P + ++
Sbjct: 7 VLSLPLLLLPAAPPPAGGCPARCECTV-----------QTRAVACTRRRLTAVPDGIPAE 55
Query: 74 TQVLLLQSNNI-AKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
T++L L N I +L L L ELD S+N +++ ANL +L L L NQ+
Sbjct: 56 TRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQL- 114
Query: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPN 192
I F L NL L L+ NKL ++ F +
Sbjct: 115 -----------------------KLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHS 151
Query: 193 LEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
L L +G+N ++ + F L L L L LT + G +L L SL +L +
Sbjct: 152 LRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIA 211
Query: 253 KVPQLALQKVPNLKFLDLNKNP-IHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNL 311
+ +++P L L+++ P + ++ G + L L L + + + +V AL +
Sbjct: 212 SLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRG-LNLTSLSVTHT-NITAVPAAALRHQ 269
Query: 312 PELTKLEATNNP-----------------------KLSYIHRLAFRSVPALESLMLNNNA 348
LT L ++NP L+ + AF + + L L+NN
Sbjct: 270 AHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNL 329
Query: 349 LNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGH 408
L+ + + T S+ L + + NPL CDC + WI + + F L CA P E +G
Sbjct: 330 LSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPA-CATPAEVRGD 388
Query: 409 QVKEVLIQDSSEQ--CLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNK 466
++ + E C + R+ G V CRA EP P + WVTP
Sbjct: 389 ALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRP 448
Query: 467 ITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
+T T + + ++ GTLEI + + +DSG YTCVA N G DT AT+ V
Sbjct: 449 VTA-TSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 157 bits (398), Expect = 2e-38
Identities = 136/560 (24%), Positives = 227/560 (40%), Gaps = 114/560 (20%)
Query: 7 VIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRI 66
++A Q +L L++ S+ S CP C C + V C+ R +
Sbjct: 19 LLACWQPILLLVLGSVLSGSATG--CPPRCECSAQD-----------RAVLCHRKRFVAV 65
Query: 67 PSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHL 126
P + ++T++L D +N + + A+ L L L
Sbjct: 66 PEGIPTETRLL-----------------------DLGKNRIKTLNQDEFASFPHLEELEL 102
Query: 127 EENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRW 186
EN ++ + +L NL+ L + N++ I F GL NL +L ++ NK+ ++
Sbjct: 103 NENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYM 162
Query: 187 FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLD------- 239
F NL+ L +G+N ++ I F L +L L L LT IP AL L
Sbjct: 163 FQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
Query: 240 -----------------------------------------SLESLSFYDNKLVKVPQLA 258
+L SLS L VP LA
Sbjct: 223 RHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA 282
Query: 259 LQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLE 318
++ + L+FL+L+ NPI I+ +LRL+E+ + G+L V+ Y
Sbjct: 283 VRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVG-GQLAVVEPY------------ 329
Query: 319 ATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCV 378
AFR + L L ++ N L + + S+ NL + + SNPL CDC
Sbjct: 330 -------------AFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCR 376
Query: 379 IHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEV--LIQDSSEQCLPMISHDSFPNRLN 436
+ W+ + + F CA P +G + K+ ++ + C D ++
Sbjct: 377 LLWVFRRRWRLNFNRQ-QPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVF 435
Query: 437 VDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGR 496
VD G TV CRA +P P I W++P + ++ ++ + + + +GTLE+ Q++D+G
Sbjct: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKS-NGRLTVFPDGTLEVRYAQVQDNGT 494
Query: 497 YTCVAQNVQGADTRVATIKV 516
Y C+A N G D+ A + V
Sbjct: 495 YLCIAANAGGNDSMPAHLHV 514
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 153 bits (386), Expect = 6e-37
Identities = 130/454 (28%), Positives = 205/454 (45%), Gaps = 60/454 (13%)
Query: 124 LHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVID 183
L L N++ + L LS LQEL +++NQ+ST+ AF GL++LL L L N+L+++
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 184 SRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLES 243
F L +L + N ++ LD F L +L+ L + +L + A GL L +
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 244 LSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGIN-------- 295
L+ L VP LAL ++P L L L + I ++ G + + +LKEL I+
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEAL 244
Query: 296 NMGELV---------------SVDRYALDNLPELTKLEATNNP-------KLSYIHRL-- 331
+ G LV SV AL +L L L+ + NP +LS + RL
Sbjct: 245 DPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQE 304
Query: 332 --------------AFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDC 377
AF + A L + +NAL + + S L + + NPL CDC
Sbjct: 305 LRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDC 364
Query: 378 VIHWINSNKTNIRF-MEPLSMFCAMPPEYKGHQVKEV--LIQDSSEQCLPMISHDSFPNR 434
+ W+ + ++ F M P + CA P +G +KE ++ C P + S P
Sbjct: 365 RLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRW 422
Query: 435 LNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDS 494
+ + G C +P P + W+ P G + + + ++ +GTLEI ++Q+ D
Sbjct: 423 VIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDGTLEIRSVQLRDR 479
Query: 495 GRYTCVAQNVQGADTRVATIKV------NGTLLD 522
G Y CV NV G D+ ++V NGTL D
Sbjct: 480 GAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSD 513
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 136 bits (343), Expect = 6e-32
Identities = 112/375 (29%), Positives = 171/375 (45%), Gaps = 34/375 (9%)
Query: 168 NLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYL 227
N L+L+ N++++I F +LEIL + N + I F LANL +L L L
Sbjct: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136
Query: 228 TDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNK-NPIHKIQEGDFKNM 286
T IP A V L L+ L +N + +P A ++P+L+ LDL + + I EG F+ +
Sbjct: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196
Query: 287 LRLKELG--------INNMGELVSVDRYAL-------------DNLPELTKLEATNNPKL 325
L+ L I N+ L+ +D L L L KL + ++
Sbjct: 197 SNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQS-QI 255
Query: 326 SYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSN 385
I R AF ++ +L + L +N L + L +L I +H NP C+C I W++
Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS-- 313
Query: 386 KTNIRFMEPLSMFCA----MPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGT 441
I+ M P + C PP KG + E L Q+ P+I P LNV G
Sbjct: 314 -WWIKDMAPSNTACCARCNTPPNLKGRYIGE-LDQNYFTCYAPVIVEP--PADLNVTEGM 369
Query: 442 TVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVA 501
L CRA + + W+TP G +T + + S+GTL +N+ ++D+G YTC+
Sbjct: 370 AAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMV 428
Query: 502 QNVQGADTRVATIKV 516
N G T AT+ V
Sbjct: 429 SNSVGNTTASATLNV 443
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/92 (28%), Positives = 45/92 (48%)
Query: 86 KTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNL 145
+ + L L L ELD S N+ + I+ L L L + ++QI + +L +L
Sbjct: 210 REIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSL 269
Query: 146 QELYINHNQISTISAHAFAGLKNLLRLHLNSN 177
E+ + HN ++ + F L +L R+HL+ N
Sbjct: 270 VEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 135 bits (340), Expect = 1e-31
Identities = 113/415 (27%), Positives = 183/415 (44%), Gaps = 32/415 (7%)
Query: 6 FVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTR 65
F++ C L+L L L SS+ C QLC ++C +L L+
Sbjct: 14 FLVVTCYLLLLLHKEILGCSSV----C-QLCT---------------GRQINCRNLGLSS 53
Query: 66 IPSNLSSDTQVLLLQSNNIAKTVD-ELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 124
IP N T L L NNI+ + EL L +L L +N + L L L
Sbjct: 54 IPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFL 113
Query: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184
L N I + + L NL+ LY+ +NQ+S + F L ++ L+L N+L V+ S
Sbjct: 114 FLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGS 173
Query: 185 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 244
F L IL + N ++ I + F+ L NL L L LT +P NA L SL L
Sbjct: 174 GTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRL 233
Query: 245 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304
S N + + A + + NL++L L + I + F + LK L I + +L +++
Sbjct: 234 SLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHL-ILSHNDLENLN 292
Query: 305 RYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLR 364
L L L+ N +S + +L+ L L+ N L A++ + ++ L +L
Sbjct: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
Query: 365 EISIHSNPLRCDCVI----HWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLI 415
+ +SNP C+C + W+ S+ L+++C PP +G ++ + I
Sbjct: 353 HLQANSNPWECNCKLLGLRDWLASSAIT------LNIYCQNPPSMRGRALRYINI 401
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 130 bits (326), Expect = 6e-30
Identities = 133/541 (24%), Positives = 219/541 (40%), Gaps = 66/541 (12%)
Query: 168 NLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYL 227
N L+L N +++I + F +LE+L +G N + I F LA+L +L L +L
Sbjct: 76 NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWL 135
Query: 228 TDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNK-NPIHKIQEGDFKNM 286
T IP A L L L +N + +P A +VP+L LDL + + I EG F+ +
Sbjct: 136 TVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGL 195
Query: 287 LRLKELGIN--------NMGELVSVDRYALD-------------NLPELTKLEATNNPKL 325
LK L + N+ LV ++ + L L KL N+ ++
Sbjct: 196 FNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNS-QV 254
Query: 326 SYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSN 385
S I R AF + +L L L +N L+++ L L E+ +H NP CDC I W+
Sbjct: 255 SLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL--- 311
Query: 386 KTNIRFMEPLSMFCA----MPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGT 441
+R P + C P +G + EV +S QC D+ P LN+ G
Sbjct: 312 AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEV--DQASFQCSAPFIMDA-PRDLNISEGR 368
Query: 442 TVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVA 501
L CR P + W+ P G ++ + + + ++GTL S++ + D+G YTC+
Sbjct: 369 MAELKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMV 426
Query: 502 QNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATM 561
NV G A + V+ L+ T ++S + V T+ + T
Sbjct: 427 TNVAGNSNASAYLNVSTAELN-----------TSNYSFFTT----VTVETTEISPEDTTR 471
Query: 562 KIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFAV 621
K T T P +T V + + + +Q + T K +
Sbjct: 472 KYKPVPTTSTGYQPA-----------YTTSTTVLIQTTRVPKQVAVPATDTTDK-----M 515
Query: 622 DISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQKTSSIPLNELY 681
S E ++G AV LA+ + + ++++ S + I ++E
Sbjct: 516 QTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDI 575
Query: 682 P 682
P
Sbjct: 576 P 576
Score = 96.7 bits (239), Expect = 7e-20
Identities = 80/297 (26%), Positives = 139/297 (46%), Gaps = 20/297 (6%)
Query: 4 MSFVIAACQL-VLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLR 62
+ FV Q+ +L + + + QN CP +C C + + V C
Sbjct: 19 LPFVYLTAQVWILCAAIAAAASAGPQN--CPSVCSCS-----------NQFSKVVCTRRG 65
Query: 63 LTRIPSNLSSDTQVLLLQSNNIAKT-VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 121
L+ +P + S+T+ L L NNI D + L +L L +N+ I+ L L
Sbjct: 66 LSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASL 125
Query: 122 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNS-NKLK 180
TL L +N +T + + LS L+EL++ +N I +I ++AF + +L+RL L KL+
Sbjct: 126 NTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLE 185
Query: 181 VIDSRWFDSTPNLEILMIGENPVIGILDM-NFKPLANLRSLVLAGMYLTDIPGNALVGLD 239
I F+ NL+ L +G + I DM N PL L L ++G + +I + GL
Sbjct: 186 YISEGAFEGLFNLKYLNLG---MCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLS 242
Query: 240 SLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINN 296
SL+ L ++++ + + A + +L L+L N + + F + L EL +++
Sbjct: 243 SLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHH 299
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/92 (30%), Positives = 47/92 (51%)
Query: 86 KTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNL 145
K + L L L EL+ S N+F I+ L+ L L + +Q++ + L++L
Sbjct: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASL 268
Query: 146 QELYINHNQISTISAHAFAGLKNLLRLHLNSN 177
EL + HN +S++ F L+ L+ LHL+ N
Sbjct: 269 VELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Score = 47.8 bits (112), Expect = 4e-05
Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 94 LFNLTELDFSQNNFTNIKEV-GLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINH 152
LFNL L+ NIK++ L L L L + N E+ LS+L++L++ +
Sbjct: 195 LFNLKYLNLGM---CNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMN 251
Query: 153 NQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENP 202
+Q+S I +AF GL +L+ L+L N L + F L L + NP
Sbjct: 252 SQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 124 bits (310), Expect = 4e-28
Identities = 126/502 (25%), Positives = 212/502 (42%), Gaps = 44/502 (8%)
Query: 56 VDCNDLRLTRIPS--NLSSDTQVLLLQSNNIAKTVDE-LQQLFNLTELDFSQNNFTNIKE 112
V N+ L IP+ +S++ +L L N I + + E L++ +L LD S NN + ++
Sbjct: 103 VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 162
Query: 113 VGLANLTQLTTLHLEENQITEMTDYCLQDLSN-LQELYINHNQISTISAHAFAGLKNLLR 171
A QL L+L N++T M +L+N L L +N N+IS I F L L
Sbjct: 163 AFPA--LQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 219
Query: 172 LHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIP 231
L LN NK+K +D F L+ L + N V ++D F L+N+ L L LT+I
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 232 GNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKE 291
L GL L+ L N + ++ A + L LDL N + ++ + F + L
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
Query: 292 LGINN-------------MGELVSVD-------------RYALDNLPELTKLEATNNPKL 325
L I N + L ++D A L +L +L N ++
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 398
Query: 326 SYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSN 385
I + AF + ALE L L++NA+ ++ + L+++ ++++ L CDC + W+
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
Query: 386 KTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFL 445
F ++ CA P KG + V P P + G+ +
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 518
Query: 446 DCRAMAEPEPEIYWVTPIGNKITVETLSDKY-KLSSEG--------TLEISNIQIEDSGR 496
C A + + + + N++ + + Y L ++G L + ++ G+
Sbjct: 519 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 578
Query: 497 YTCVAQNVQGADTRV-ATIKVN 517
Y CV N G+ V A + VN
Sbjct: 579 YQCVISNHFGSSYSVKAKLTVN 600
Score = 114 bits (285), Expect = 3e-25
Identities = 131/514 (25%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 59 NDLRLTRIPSNLSSDTQVLLLQSN-NIAKTVDEL--QQLFNLTELDFSQNNFTNIKEVGL 115
N R++ IP + Q+ L+ N N K VD L Q L L L +N T + +
Sbjct: 200 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 259
Query: 116 ANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLN 175
L+ + L L+ N +TE+T L L LQEL+++ N I+ IS A+ + L L L
Sbjct: 260 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 319
Query: 176 SNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLT----DIP 231
N L +D F L L IG N V I D F+ L++L++L L ++ D+
Sbjct: 320 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN 379
Query: 232 GNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKE 291
G A GLD L L N++ + + A + L+ LDL+ N I +Q F M +L++
Sbjct: 380 G-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 438
Query: 292 LGINNMGEL--------------------------------------VSVDRYALDNLP- 312
L +N L VS D + D+ P
Sbjct: 439 LHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPK 498
Query: 313 -----ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLR--- 364
+ A LS+I A S + +N L ++ +E+ +LR
Sbjct: 499 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG 556
Query: 365 -EISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEY-KGHQVKEVLIQDSSEQC 422
E+ ++ LR + F C + + + VK L +
Sbjct: 557 GEVMEYTTILRL-----------REVEFASEGKYQCVISNHFGSSYSVKAKL----TVNM 601
Query: 423 LPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEG 482
LP S P L + G L+C A+ P P+I W G + + +
Sbjct: 602 LP--SFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDD 659
Query: 483 TLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
I +++IED G Y+C AQN G+ + AT+ V
Sbjct: 660 VFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/227 (28%), Positives = 104/227 (45%), Gaps = 31/227 (13%)
Query: 148 LYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGIL 207
L ++HN++S I A + + L++L + LN+N+L+ I PNL PV
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI--------PNL-------GPV---- 119
Query: 208 DMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKF 267
AN+ L LAG + +I L SLE+L N + ++ Q A + LK+
Sbjct: 120 ------SANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKY 171
Query: 268 LDLNKNPIHKIQEGDFKNMLR-LKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLS 326
L LN N + ++ G F N+ L L +N +S + LP+L LE N K+
Sbjct: 172 LYLNSNRVTSMEPGYFDNLANTLLVLKLNR--NRISAIPPKMFKLPQLQHLELNRN-KIK 228
Query: 327 YIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
+ L F+ + AL+SL + N + + L N+ + + N L
Sbjct: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275
Score = 33.9 bits (76), Expect = 0.54
Identities = 24/94 (25%), Positives = 37/94 (39%), Gaps = 6/94 (6%)
Query: 418 SSEQCLPMISHDSFPNRL---NVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSD 474
S+ L ++ SF L V G T L C A P P++ W + E
Sbjct: 686 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER--- 742
Query: 475 KYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGAD 508
+ + L I + + D+G+YTC N G +
Sbjct: 743 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE 776
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 124 bits (310), Expect = 4e-28
Identities = 126/502 (25%), Positives = 212/502 (42%), Gaps = 44/502 (8%)
Query: 56 VDCNDLRLTRIPS--NLSSDTQVLLLQSNNIAKTVDE-LQQLFNLTELDFSQNNFTNIKE 112
V N+ L IP+ +S++ +L L N I + + E L++ +L LD S NN + ++
Sbjct: 43 VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT 102
Query: 113 VGLANLTQLTTLHLEENQITEMTDYCLQDLSN-LQELYINHNQISTISAHAFAGLKNLLR 171
A QL L+L N++T M +L+N L L +N N+IS I F L L
Sbjct: 103 AFPA--LQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159
Query: 172 LHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIP 231
L LN NK+K +D F L+ L + N V ++D F L+N+ L L LT+I
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 232 GNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKE 291
L GL L+ L N + ++ A + L LDL N + ++ + F + L
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279
Query: 292 LGINN-------------MGELVSVD-------------RYALDNLPELTKLEATNNPKL 325
L I N + L ++D A L +L +L N ++
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN-RI 338
Query: 326 SYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSN 385
I + AF + ALE L L++NA+ ++ + L+++ ++++ L CDC + W+
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
Query: 386 KTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFL 445
F ++ CA P KG + V P P + G+ +
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF 458
Query: 446 DCRAMAEPEPEIYWVTPIGNKITVETLSDKY-KLSSEG--------TLEISNIQIEDSGR 496
C A + + + + N++ + + Y L ++G L + ++ G+
Sbjct: 459 ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK 518
Query: 497 YTCVAQNVQGADTRV-ATIKVN 517
Y CV N G+ V A + VN
Sbjct: 519 YQCVISNHFGSSYSVKAKLTVN 540
Score = 114 bits (285), Expect = 3e-25
Identities = 131/514 (25%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 59 NDLRLTRIPSNLSSDTQVLLLQSN-NIAKTVDEL--QQLFNLTELDFSQNNFTNIKEVGL 115
N R++ IP + Q+ L+ N N K VD L Q L L L +N T + +
Sbjct: 140 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 199
Query: 116 ANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLN 175
L+ + L L+ N +TE+T L L LQEL+++ N I+ IS A+ + L L L
Sbjct: 200 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 259
Query: 176 SNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLT----DIP 231
N L +D F L L IG N V I D F+ L++L++L L ++ D+
Sbjct: 260 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN 319
Query: 232 GNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKE 291
G A GLD L L N++ + + A + L+ LDL+ N I +Q F M +L++
Sbjct: 320 G-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
Query: 292 LGINNMGEL--------------------------------------VSVDRYALDNLP- 312
L +N L VS D + D+ P
Sbjct: 379 LHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPK 438
Query: 313 -----ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLR--- 364
+ A LS+I A S + +N L ++ +E+ +LR
Sbjct: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL--LHDAEMENYAHLRAQG 496
Query: 365 -EISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEY-KGHQVKEVLIQDSSEQC 422
E+ ++ LR + F C + + + VK L +
Sbjct: 497 GEVMEYTTILRL-----------REVEFASEGKYQCVISNHFGSSYSVKAKL----TVNM 541
Query: 423 LPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEG 482
LP S P L + G L+C A+ P P+I W G + + +
Sbjct: 542 LP--SFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDD 599
Query: 483 TLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
I +++IED G Y+C AQN G+ + AT+ V
Sbjct: 600 VFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
Score = 64.3 bits (155), Expect = 4e-10
Identities = 63/225 (28%), Positives = 103/225 (45%), Gaps = 31/225 (13%)
Query: 150 INHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDM 209
++HN++S I A + + L++L + LN+N+L+ I PNL PV
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETI--------PNL-------GPV------ 59
Query: 210 NFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLD 269
AN+ L LAG + +I L SLE+L N + ++ Q A + LK+L
Sbjct: 60 ----SANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLY 113
Query: 270 LNKNPIHKIQEGDFKNMLR-LKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYI 328
LN N + ++ G F N+ L L +N +S + LP+L LE N K+ +
Sbjct: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNR--NRISAIPPKMFKLPQLQHLELNRN-KIKNV 170
Query: 329 HRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
L F+ + AL+SL + N + + L N+ + + N L
Sbjct: 171 DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 215
Score = 33.9 bits (76), Expect = 0.54
Identities = 24/94 (25%), Positives = 37/94 (39%), Gaps = 6/94 (6%)
Query: 418 SSEQCLPMISHDSFPNRL---NVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSD 474
S+ L ++ SF L V G T L C A P P++ W + E
Sbjct: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER--- 682
Query: 475 KYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGAD 508
+ + L I + + D+G+YTC N G +
Sbjct: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE 716
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 122 bits (307), Expect = 9e-28
Identities = 120/437 (27%), Positives = 187/437 (42%), Gaps = 88/437 (20%)
Query: 124 LHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVID 183
L L +N +T + ++++L +L ++ N IS I+ HAFA L+NL LHLNSN+L I
Sbjct: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
Query: 184 SRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLES 243
+ DM F L+NL L+L LT I A + +LE
Sbjct: 116 N-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFALEE 151
Query: 244 LSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSV 303
L N L +P A++K+ +L L L+ N I I +G F
Sbjct: 152 LDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTF-------------------- 191
Query: 304 DRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNL 363
+L ++T+L+ T+N F+ L A + I P+
Sbjct: 192 -----SHLHKMTRLDVTSNKLQKLPPDPLFQRAQVL--------ATSGIIS------PST 232
Query: 364 REISIHSNPLRCDCVIHWIN--SNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQ 421
+S NPL C+C + W+ S + ++ CA PP G + E+
Sbjct: 233 FALSFGGNPLHCNCELLWLRRLSREDDLE-------TCASPPLLTGRYFWSI----PEEE 281
Query: 422 CL---PMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKL 478
L P+I+ + + + V G L C+A +PEP I+W++P G I+ T S Y
Sbjct: 282 FLCEPPLITRHT--HEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVY-- 337
Query: 479 SSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGT--LLDGTQVLKIYVKQTES 536
GTL+I ++D+G +TC+A N G T++ + + LL+ T I+ S
Sbjct: 338 -DNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTN--HIHEPDPGS 394
Query: 537 HSILVSWKVNSNVMTSN 553
I S K SN +SN
Sbjct: 395 SDISTSTKSGSNTSSSN 411
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/256 (29%), Positives = 110/256 (42%), Gaps = 43/256 (16%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDEL 91
CP+ CVC+I +P AT C L +P N+ T
Sbjct: 20 CPKRCVCQI---LSPNL----ATL--CAKKGLLFVPPNIDRRT----------------- 53
Query: 92 QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYIN 151
EL + N TNIK AN+T L L L N I+ +T + DL NL+ L++N
Sbjct: 54 ------VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLN 107
Query: 152 HNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNF 211
N+++ I+ F+GL NL L LN+N+L +I S FD LE L + N + I
Sbjct: 108 SNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAV 167
Query: 212 KPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQ---------LALQKV 262
+ + +L +L L + +IP L + L NKL K+P LA +
Sbjct: 168 EKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGI 227
Query: 263 --PNLKFLDLNKNPIH 276
P+ L NP+H
Sbjct: 228 ISPSTFALSFGGNPLH 243
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 122 bits (307), Expect = 9e-28
Identities = 108/343 (31%), Positives = 157/343 (45%), Gaps = 13/343 (3%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTV-DE 90
CP C CE P R VDC+DL L+ +PSNLS T L L NNI++ + +
Sbjct: 34 CPTHCHCE------PDG--RMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNP 85
Query: 91 LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI 150
L L L EL + N T I + L L L L+ NQ+ + LQ+L +LQ L +
Sbjct: 86 LPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRL 145
Query: 151 NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMN 210
+ N IS + F+GL +L L L+ N L I + F S L+ + + N + I D
Sbjct: 146 DANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYA 205
Query: 211 FKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270
F L++L L L + + GL SLE+L N L + P A++ + NLK L
Sbjct: 206 FGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP-TAIRTLSNLKELGF 264
Query: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
+ N I I E F L + + + V R A +LPEL L +++
Sbjct: 265 HSNNIRSIPEKAFVGNPSLITIHFYD-NPIQFVGRSAFQHLPELRTLTLNGASQITEFPD 323
Query: 331 LAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
L LESL L ++++ Q LPNL+ + + N L
Sbjct: 324 LT--GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Score = 101 bits (252), Expect = 2e-21
Identities = 78/286 (27%), Positives = 135/286 (47%), Gaps = 12/286 (4%)
Query: 88 VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQE 147
V + L L + + N +I + NL+ L LHL N+I + C L +L+
Sbjct: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238
Query: 148 LYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGIL 207
L +N+N + A L NL L +SN ++ I + F P+L + +NP+ +
Sbjct: 239 LDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
Query: 208 DMNFKPLANLRSLVLAGM-YLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLK 266
F+ L LR+L L G +T+ P L G +LESL+ ++ +PQ ++PNL+
Sbjct: 298 RSAFQHLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
Query: 267 FLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNP--K 324
LDL+ N + + L+ +L N + E+ +D +L L + N K
Sbjct: 356 VLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEI------KVDTFQQLLSLRSLNLAWNK 409
Query: 325 LSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHS 370
++ IH AF ++P+L L L++N L++ + L +L+ H+
Sbjct: 410 IAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHA 455
Score = 66.6 bits (161), Expect = 8e-11
Identities = 64/245 (26%), Positives = 105/245 (42%), Gaps = 10/245 (4%)
Query: 75 QVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEM 134
+ L L NN+ + ++ L NL EL F NN +I E L T+H +N I +
Sbjct: 237 ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV 296
Query: 135 TDYCLQDLSNLQELYINH-NQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNL 193
Q L L+ L +N +QI+ G NL L L ++ + + PNL
Sbjct: 297 GRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
Query: 194 EILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVK 253
++L + N + + +F L+ + L + +I + L SL SL+ NK+
Sbjct: 355 QVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 412
Query: 254 VPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPE 313
+ A +P+L LDL+ N + + LK G + + L+S +N PE
Sbjct: 413 IHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLIS-----SENFPE 467
Query: 314 LTKLE 318
L +E
Sbjct: 468 LKVIE 472
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/160 (24%), Positives = 70/160 (43%), Gaps = 14/160 (8%)
Query: 96 NLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQI 155
NL L + +++ + L L L L N + ++ + + LQ++ + HN+I
Sbjct: 329 NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSV--CQKLQKIDLRHNEI 386
Query: 156 STISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLA 215
I F L +L L+L NK+ +I F + P+L L + N + P+
Sbjct: 387 YEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF------PIT 440
Query: 216 NLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVP 255
L L +L +AL L S E +F + K++++P
Sbjct: 441 GLHGLT----HLKLTGNHALQSLISSE--NFPELKVIEMP 474
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 120 bits (302), Expect = 3e-27
Identities = 104/375 (27%), Positives = 164/375 (43%), Gaps = 32/375 (8%)
Query: 168 NLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYL 227
N L+L N ++VI + F +LEIL + +N V I F L +L +L L L
Sbjct: 87 NTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRL 146
Query: 228 TDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNK-NPIHKIQEGDFKNM 286
T +P A L L L +N + +P A +VP+L+ LDL + + I E F+ +
Sbjct: 147 TTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGL 206
Query: 287 LRLKELGINNMGELVSVDRYALDNLPELTKLEATNN-----------------------P 323
+ L+ L N+G D L L L +LE + N
Sbjct: 207 VNLRYL---NLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA 263
Query: 324 KLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWIN 383
+++ I R AF + +LE L L++N L ++ L L + ++ NP C+C + W++
Sbjct: 264 QVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLS 323
Query: 384 -SNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTT 442
K + C P KG + E L Q P+I P LNV G
Sbjct: 324 WWLKETVPSNTTCCARCHAPAGLKGRYIGE-LDQSHFTCYAPVIVEP--PTDLNVTEGMA 380
Query: 443 VFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQ 502
L CR + W+TP G +T + + + +GTL +N+ ++D+G+YTC+
Sbjct: 381 AELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVT 439
Query: 503 NVQGADTRVATIKVN 517
N G T AT+ V+
Sbjct: 440 NSAGNTTASATLNVS 454
Score = 89.4 bits (220), Expect = 1e-17
Identities = 73/270 (27%), Positives = 125/270 (46%), Gaps = 17/270 (6%)
Query: 30 SECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-V 88
+ CP C C +A+ V C L +P+++ +T+ L LQ N I
Sbjct: 55 TSCPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRT 103
Query: 89 DELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQEL 148
D + L +L L S+N I+ L L TL L +N++T + + LS L+EL
Sbjct: 104 DTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLREL 163
Query: 149 YINHNQISTISAHAFAGLKNLLRLHLNS-NKLKVIDSRWFDSTPNLEILMIGENPVIGIL 207
++ +N I +I ++AF + +L RL L +L+ I F+ NL L +G + +
Sbjct: 164 WLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLG---MCNLK 220
Query: 208 DM-NFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLK 266
D+ N L L L L+G L I + GL SL L ++ + + A + +L+
Sbjct: 221 DIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLE 280
Query: 267 FLDLNKNPIHKIQEGDFKNMLRLKELGINN 296
L+L+ N + + F + RL+ + +N+
Sbjct: 281 ELNLSHNNLMSLPHDLFTPLHRLERVHLNH 310
Score = 52.0 bits (123), Expect = 2e-06
Identities = 30/92 (32%), Positives = 43/92 (46%)
Query: 86 KTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNL 145
K + L L L EL+ S N I+ LT L L L Q+ + DL +L
Sbjct: 220 KDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSL 279
Query: 146 QELYINHNQISTISAHAFAGLKNLLRLHLNSN 177
+EL ++HN + ++ F L L R+HLN N
Sbjct: 280 EELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 1/107 (0%)
Query: 97 LTELDFSQNNFTNIKEV-GLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQI 155
L L + N+K++ L L +L L L N++ + Q L++L++L++ H Q+
Sbjct: 206 LVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265
Query: 156 STISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENP 202
+TI +AF LK+L L+L+ N L + F LE + + NP
Sbjct: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNP 312
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 120 bits (300), Expect = 6e-27
Identities = 116/490 (23%), Positives = 199/490 (40%), Gaps = 45/490 (9%)
Query: 59 NDLRLTRIPSNLSSDTQV--LLLQSNNIAKTV-DELQQLFNLTELDFSQNNFTNIKEVGL 115
N+ LT +PS ++ + V L LQ N I +L+ +L LD S NN T ++
Sbjct: 100 NNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCF 159
Query: 116 ANLTQLTTLHLEENQITEMTDYCLQDLS-NLQELYINHNQISTISAHAFAGLKNLLRLHL 174
+ + L+L N+I + LS +L L ++ N+I+ + AF L L +L L
Sbjct: 160 PHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDL 218
Query: 175 NSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNA 234
N N++++I+ F +LE+L + N + + D F L+ + L L L ++ +
Sbjct: 219 NRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGS 278
Query: 235 LVGLDSLESLSFYDNKLVKV------------------------PQLALQKVPNLKFLDL 270
L GL +L L +N + ++ + +L ++ +L L L
Sbjct: 279 LYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRL 338
Query: 271 NKNPIHKIQEGDFKNM--LRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYI 328
+ N I I EG FK + LR+ +L N + + A L L+KL N K+ +
Sbjct: 339 SHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGN-KIKSV 397
Query: 329 HRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTN 388
+ AF + LE L L NA+ ++ + NL+E+ I S+ CDC + W+
Sbjct: 398 AKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIG 457
Query: 389 IRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHD--SFPNRLNVDIGTTVFLD 446
++ CA P KG + V S C + + P +G +
Sbjct: 458 RMLQAFVTATCAHPESLKGQSIFSV--PPESFVCDDFLKPQIITQPETTMAMVGKDIRFT 515
Query: 447 CRAMAEPEPEIYWVTPIGNKITVET---------LSDKYKLSSEGTLEISNIQIEDSGRY 497
C A + + + N++ D + L + + GRY
Sbjct: 516 CSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRY 575
Query: 498 TCVAQNVQGA 507
CV N G+
Sbjct: 576 QCVITNHFGS 585
Score = 84.3 bits (207), Expect = 3e-16
Identities = 72/275 (26%), Positives = 136/275 (49%), Gaps = 27/275 (9%)
Query: 123 TLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVI 182
+L+L N+++E+ +DL NLQE+Y+N+N+++ + + A +++ L L NK++ +
Sbjct: 72 SLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG-AASSHVVSLFLQHNKIRSV 130
Query: 183 DSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLD-SL 241
+ + +LE+L + N + + + F ++ L LAG + + A GL SL
Sbjct: 131 EGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSL 190
Query: 242 ESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFK--NMLRLKELGINNMGE 299
+L N++ ++P A K+P L LDLN+N I I+ F+ N L + +L NN+ +
Sbjct: 191 LTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK 249
Query: 300 ---------------------LVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPA 338
LV V+ +L L L +L +NN ++ IHR +
Sbjct: 250 LTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNN-SIARIHRKGWSFCQK 308
Query: 339 LESLMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
L L+L+ N L + ++++ L +L + + N +
Sbjct: 309 LHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSI 343
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 8/94 (8%)
Query: 437 VDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTL-EISNIQIEDSG 495
V +G TV L C+A P P I W G++ +L++++ L+ + L + N+ ED+G
Sbjct: 704 VSVGETVALQCKATGNPPPRITWFK--GDRPL--SLTERHHLTPDNQLLVVQNVVAEDAG 759
Query: 496 RYTCVAQNVQG---ADTRVATIKVNGTLLDGTQV 526
RYTC N G A ++++ + G DGT V
Sbjct: 760 RYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTV 793
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/85 (27%), Positives = 41/85 (48%)
Query: 432 PNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQI 491
P+ + + T L+C A P P+I W G + + + I++++I
Sbjct: 605 PHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKI 664
Query: 492 EDSGRYTCVAQNVQGADTRVATIKV 516
+D+G Y+C AQN G+ + AT+ V
Sbjct: 665 DDAGVYSCTAQNSAGSISANATLTV 689
Score = 30.4 bits (67), Expect = 6.0
Identities = 16/43 (37%), Positives = 23/43 (53%)
Query: 310 NLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAI 352
+LP T+ + KLS I F +P L+ + LNNN L A+
Sbjct: 65 DLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV 107
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 118 bits (295), Expect = 2e-26
Identities = 107/412 (25%), Positives = 180/412 (43%), Gaps = 38/412 (9%)
Query: 118 LTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSN 177
L L L L+ N+I + Q L +L+ L + N IS + AF GL N+ L L N
Sbjct: 214 LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHN 273
Query: 178 KLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVG 237
L ++ W L+ L + +N + I ++ L L L+ LT + +A VG
Sbjct: 274 NLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVG 333
Query: 238 LDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNM 297
L LE L+ DN++ + + + NL+ LDL N I I +
Sbjct: 334 LSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEI---------------SWAIEDA 378
Query: 298 GELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTV 357
E A L LTKL N ++ I + AF + +LE L LNNNA+ +I Q+
Sbjct: 379 SE-------AFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEHLDLNNNAIMSI-QENA 429
Query: 358 ESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQD 417
S +L+E+ ++++ L CDC + W+ + F +++ CA P G + V ++D
Sbjct: 430 FSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKD 489
Query: 418 --SSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDK 475
+ P I + P + G V L C A++ + + V ++I + ++
Sbjct: 490 FVCDDFLKPQIR--THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTEN 547
Query: 476 Y---------KLSSEGTLEISNIQIEDSGRYTCVAQNVQGAD-TRVATIKVN 517
+ L L + N+ D G+Y C+ N G++ ++ A + VN
Sbjct: 548 FVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVN 599
Score = 97.4 bits (241), Expect = 4e-20
Identities = 81/247 (32%), Positives = 119/247 (48%), Gaps = 9/247 (3%)
Query: 56 VDCNDLRLTRIPSNLSS--DTQVLLLQSNNIAKTVDEL--QQLFNLTELDFSQNNFTNIK 111
V N R++ IP + Q L L+ N I K V+ L Q L +L L +N + +K
Sbjct: 197 VKLNRNRMSMIPPKIFKLPHLQFLELKRNRI-KIVEGLTFQGLDSLRSLKMQRNGISKLK 255
Query: 112 EVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLR 171
+ L + L LE N +T + L L LQ+LY++ N I IS A+ + L
Sbjct: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
Query: 172 LHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAG---MYLT 228
L L+ N+L +D F LE L +G+N V I D F+ L+NL++L L +
Sbjct: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
Query: 229 DIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLR 288
+ A GL SL L N++ + + A + +L+ LDLN N I IQE F +
Sbjct: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTH 434
Query: 289 LKELGIN 295
LKEL +N
Sbjct: 435 LKELILN 441
Score = 57.0 bits (136), Expect = 6e-08
Identities = 64/254 (25%), Positives = 117/254 (46%), Gaps = 19/254 (7%)
Query: 132 TEMTDYCLQDLSN---------LQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVI 182
T + D+ LSN LQE+ +N+N+++ I N+ L L N + I
Sbjct: 77 TAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIPEI 135
Query: 183 DSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDS-L 241
+++ P LE L + N + I +F P L+ L L+ +T + L S L
Sbjct: 136 NAQALQFYPALESLDLSSNIISEIKTSSF-PRMQLKYLNLSNNRITTLEAGCFDNLSSSL 194
Query: 242 ESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGI--NNMGE 299
+ N++ +P + K+P+L+FL+L +N I ++ F+ + L+ L + N + +
Sbjct: 195 LVVKLNRNRMSMIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISK 253
Query: 300 LVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVES 359
L + L+N+ EL +LE N L+ +++ + L+ L ++ NA+ I E
Sbjct: 254 LKDGAFFGLNNMEEL-ELEHNN---LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEF 309
Query: 360 LPNLREISIHSNPL 373
L E+ + N L
Sbjct: 310 CQRLSELDLSYNQL 323
Score = 50.4 bits (119), Expect = 6e-06
Identities = 48/179 (26%), Positives = 82/179 (45%), Gaps = 13/179 (7%)
Query: 202 PVIGILDMNFKPLAN---------LRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLV 252
P ILD + L+N L+ + + LT+IP ++ LS N +
Sbjct: 75 PDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIP 133
Query: 253 KVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLP 312
++ ALQ P L+ LDL+ N I +I+ F M +LK L ++N + +++ DNL
Sbjct: 134 EINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN-NRITTLEAGCFDNLS 191
Query: 313 ELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSN 371
+ N ++S I F+ +P L+ L L N + + T + L +LR + + N
Sbjct: 192 SSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRN 249
Score = 47.8 bits (112), Expect = 4e-05
Identities = 25/85 (29%), Positives = 39/85 (45%)
Query: 432 PNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQI 491
P L + G L+C A P P+I W G + + + I+N++I
Sbjct: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
Query: 492 EDSGRYTCVAQNVQGADTRVATIKV 516
ED G Y+C+AQN G + A++ V
Sbjct: 668 EDMGIYSCMAQNTAGGLSANASLTV 692
Score = 38.9 bits (89), Expect = 0.017
Identities = 26/94 (27%), Positives = 40/94 (42%), Gaps = 6/94 (6%)
Query: 418 SSEQCLPMISHDSFPNRLN---VDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSD 474
S+ L ++ SF L V G T L C A P P + W G + E
Sbjct: 685 SANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTER--- 741
Query: 475 KYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGAD 508
+ ++ L I + +ED+G+YTC+ N G +
Sbjct: 742 HFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTE 775
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 117 bits (292), Expect = 5e-26
Identities = 103/365 (28%), Positives = 161/365 (44%), Gaps = 18/365 (4%)
Query: 11 CQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNL 70
C L LGLL S S C C C+ VDC+ LT +P L
Sbjct: 9 CFLALGLL-GSAGPSGAAPPLCAAPCSCD------------GDRRVDCSGKGLTAVPEGL 55
Query: 71 SSDTQVLLLQSNNIAKTVDELQQLFN-LTELDFSQNNFTNIKEVGLANLTQLTTLHLEEN 129
S+ TQ L + NNI + ++ + F L EL + N+ + I L+ L +L L L+ N
Sbjct: 56 SAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNN 115
Query: 130 QITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDS 189
Q+ + ++ LS LQ L ++ N I+++ +F GL L L L+ N L + +
Sbjct: 116 QLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSN 175
Query: 190 TPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDN 249
P L+ L + N + I D F L++L L L + + + GLD+LE+L N
Sbjct: 176 LPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYN 235
Query: 250 KLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALD 309
L + PQ A++ +P+LK L + N I I +G F L+ + + + L V A
Sbjct: 236 NLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYD-NPLSFVGNSAFH 293
Query: 310 NLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIH 369
NL +L L + L LESL L +++I + LR + +
Sbjct: 294 NLSDLHSLVIRGASMVQQFPNLT--GTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
Query: 370 SNPLR 374
N +R
Sbjct: 352 YNNIR 356
Score = 90.1 bits (222), Expect = 6e-18
Identities = 80/312 (25%), Positives = 132/312 (42%), Gaps = 53/312 (16%)
Query: 77 LLLQSNNIAKT-VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMT 135
L L N++ + V L L L L + N ++I + NL+ L LHL N+I ++
Sbjct: 158 LWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLS 217
Query: 136 DYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEI 195
+C L NL+ L +N+N + A L +L L +SN + VI FD P L
Sbjct: 218 QHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRT 276
Query: 196 LMIGENPVIGILDMNFKPLANLRSLV-----------------------LAGMYLTDIPG 232
+ + +NP+ + + F L++L SLV L G ++ IP
Sbjct: 277 IHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPN 336
Query: 233 N----------------------ALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDL 270
N + G +LE +S N++ ++ + Q + +L+ LDL
Sbjct: 337 NLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDL 396
Query: 271 NKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
++N IH+I F + + L + + EL S + + L L +L+ N KL
Sbjct: 397 SRNLIHEIHSRAFATLGPITNLDV-SFNELTS---FPTEGLNGLNQLKLVGNFKLK--EA 450
Query: 331 LAFRSVPALESL 342
LA + L SL
Sbjct: 451 LAAKDFVNLRSL 462
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 115 bits (288), Expect = 1e-25
Identities = 90/300 (30%), Positives = 150/300 (50%), Gaps = 15/300 (5%)
Query: 249 NKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYAL 308
N++ ++ A +++ NL L LN N I +I G F+++ LK L + E+ S+DR A
Sbjct: 72 NRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYK-NEIQSIDRQAF 130
Query: 309 DNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISI 368
L L +L N ++ + +F+ +P LE L L+NN + + T L +++ + +
Sbjct: 131 KGLASLEQLYLHFN-QIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRL 189
Query: 369 HSNPLRCDCVIHWI-NSNKTNIRF-MEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMI 426
SN L CDC I W+ + KT + C P +G V + ++ + + P I
Sbjct: 190 DSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCE-RPRI 248
Query: 427 SHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEI 486
+ S P +V G TV+ CRA P+PEI W+ N+++++T + L +GTL I
Sbjct: 249 T--SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRN-NNELSMKT-DSRLNLLDDGTLMI 304
Query: 487 SNIQIEDSGRYTCVAQNVQG-ADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKV 545
N Q D G Y C+A+NV G T+ T++ G+ T +V Q ++ +LV V
Sbjct: 305 QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPT-----FVIQPQNTEVLVGESV 359
Score = 74.3 bits (181), Expect = 4e-13
Identities = 87/364 (23%), Positives = 147/364 (40%), Gaps = 22/364 (6%)
Query: 148 LYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGIL 207
L + N+I I AF L+NL L LN+N++K I S F+ NL+ L + +N + I
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 208 DMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKF 267
FK LA+L L L + + ++ L LE L ++N++ + + ++K
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
Query: 268 LDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELT--KLEATNNPKL 325
L L+ N +H E +L L +L + E + A+ P + AT P+
Sbjct: 187 LRLDSNTLHCDCE-----ILWLADL-LKTYAESGNAQAAAICEYPRRIQGRSVATITPEE 240
Query: 326 SYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSN---PLRCDCVIHWI 382
R S P + N + E P I + +N ++ D ++ +
Sbjct: 241 LNCERPRITSEPQDADVTSGN---TVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL 297
Query: 383 NSNKTNIRFMEPL--SMFCAMPPEYKGH-QVKEVLIQDSSEQCLPMISHDSFPNRLNVDI 439
+ I+ + ++ M G + +EV ++ P P V +
Sbjct: 298 DDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ--PQNTEVLV 355
Query: 440 GTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTC 499
G +V L+C A P P I W + V+ + ++ G L I N+ DSG Y C
Sbjct: 356 GESVTLECSATGHPPPRISWTRGDRTPLPVD---PRVNITPSGGLYIQNVVQGDSGEYAC 412
Query: 500 VAQN 503
A N
Sbjct: 413 SATN 416
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 37/191 (19%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDEL 91
CP C+C +R TTV C L L +P+ ++ T +L L+ N I +
Sbjct: 36 CPSRCLC-----------FR--TTVRCMHLLLEAVPA-VAPQTSILDLRFNRIRE----- 76
Query: 92 QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYIN 151
I+ L L TL L NQI + +DL NL+ LY+
Sbjct: 77 ------------------IQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLY 118
Query: 152 HNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNF 211
N+I +I AF GL +L +L+L+ N+++ +D F P LE L + N + ++ F
Sbjct: 119 KNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTF 178
Query: 212 KPLANLRSLVL 222
L +++ L L
Sbjct: 179 NHLESMKRLRL 189
Score = 60.8 bits (146), Expect = 4e-09
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 430 SFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVE-TLSDKYKLSSEGTLEISN 488
S P+ V++G V L C + EPEP I W NK V+ T S K+ +S EG L I++
Sbjct: 529 SIPSDTTVEVGANVQLPCSSQGEPEPAITW-----NKDGVQVTESGKFHISPEGFLTIND 583
Query: 489 IQIEDSGRYTCVAQNVQGADTRVATIKVN 517
+ D+GRY CVA+N G+ + + VN
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVN 612
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/132 (31%), Positives = 65/132 (49%)
Query: 120 QLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKL 179
Q + L L N+I E+ + L NL L +N+NQI I + AF L+NL L+L N++
Sbjct: 63 QTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEI 122
Query: 180 KVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLD 239
+ ID + F +LE L + N + + +F+ L L L L +T + L+
Sbjct: 123 QSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLE 182
Query: 240 SLESLSFYDNKL 251
S++ L N L
Sbjct: 183 SMKRLRLDSNTL 194
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/77 (36%), Positives = 42/77 (54%), Gaps = 4/77 (5%)
Query: 440 GTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTC 499
G TV C A P P I W T G++++V+ ++ + S GTL IS + + D G+Y C
Sbjct: 447 GQTVDFQCEAKGNPPPVIAW-TKGGSQLSVDR---RHLVLSSGTLRISGVALHDQGQYEC 502
Query: 500 VAQNVQGADTRVATIKV 516
A N+ G+ VA + V
Sbjct: 503 QAVNIIGSQKVVAHLTV 519
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 114 bits (285), Expect = 3e-25
Identities = 106/386 (27%), Positives = 162/386 (41%), Gaps = 74/386 (19%)
Query: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDEL 91
CP+ CVC P+S + C L +P SDTQ+L
Sbjct: 396 CPRACVC------VPESRHSS-----CEGCGLQAVPRGFPSDTQLL-------------- 430
Query: 92 QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYIN 151
D +N+F ++ L L +LHL+ I E+ L L L LY++
Sbjct: 431 ---------DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLS 481
Query: 152 HNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNF 211
NQ++ +SA A G L L+L N+ + + P+L L + +N V + +
Sbjct: 482 DNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDL 541
Query: 212 KPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLN 271
LR + L+G +T++ AL LE L N+L +VP AL+ +P L L L+
Sbjct: 542 GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLS 601
Query: 272 KNPIHKIQEGDFKNMLR-LKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHR 330
NP+ +++G F+ + R L+ L +N+ G L I
Sbjct: 602 GNPLRALRDGAFQPVGRSLQHLFLNSSG--------------------------LEQICP 635
Query: 331 LAFRSV-PALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVI----HWINSN 385
AF + P L+SL L N L A+ + SL L I + SNP CDC + W+
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTG- 692
Query: 386 KTNIRFMEPLSMFCAMPPEYKGHQVK 411
N+R + CA PP +G +VK
Sbjct: 693 -LNLR----VGATCATPPNARGQRVK 713
Score = 82.8 bits (203), Expect = 1e-15
Identities = 97/378 (25%), Positives = 147/378 (38%), Gaps = 72/378 (19%)
Query: 13 LVLGLLMTSLTESSIQNS--ECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNL 70
LVL LL+ L + Q + CPQ C+C+ V C LT +P +
Sbjct: 12 LVLPLLVLLLLAPARQAAAQRCPQACICD-----------NSRRHVACRYQNLTEVPDAI 60
Query: 71 SSDTQVLLLQSNNIAKTVDE--LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEE 128
TQ L LQ N + K + Q + +LT LD + E L +L L+L
Sbjct: 61 PELTQRLDLQGN-LLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLAS 119
Query: 129 NQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFD 188
N + E+ L L +L+ L + N + + F L L L+L N L + +
Sbjct: 120 NHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPA---- 175
Query: 189 STPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYD 248
M F+ L +R L L+ L+ + AL GL +L LS +
Sbjct: 176 --------------------MAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHH 215
Query: 249 NKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYAL 308
N+L +P L + L L+L NP+ E D + L+EL +D AL
Sbjct: 216 NELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLREL---------LLDGGAL 266
Query: 309 DNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISI 368
L P+ AF P L +L L N L+ + ++ LR + +
Sbjct: 267 QAL----------GPR-------AFAHCPRLHTLDLRGNQLDTL--PPLQGPGQLRRLRL 307
Query: 369 HSNPLRCDC----VIHWI 382
NPL C C ++ W+
Sbjct: 308 QGNPLWCGCQARPLLEWL 325
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 112 bits (281), Expect = 9e-25
Identities = 98/384 (25%), Positives = 161/384 (41%), Gaps = 53/384 (13%)
Query: 75 QVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEM 134
++++ S+ A L L L S+N T++ L + L L L+ N + +
Sbjct: 78 RLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGI 137
Query: 135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLL------------------------ 170
Q L NLQEL +N NQ+ + A F L+NL
Sbjct: 138 DQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLE 197
Query: 171 RLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDI 230
RL L+SN+L +DS +S L L N + I F L NL SL L+ +L +
Sbjct: 198 RLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFL 257
Query: 231 PGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLK 290
P + +L L+ ++N L ++P + ++ L+ L LN+ + + F+N+ RL+
Sbjct: 258 PSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLR 317
Query: 291 ELGINNMGELVSVDRYALDNLPELTKLEATNN-----------------------PKLSY 327
LG+ L ++ + A L EL L +N +L
Sbjct: 318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRA 377
Query: 328 IHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDC----VIHWIN 383
+ R FR++ +LES+ L++N L + +LP L E+ + N RCDC + W+
Sbjct: 378 LPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLR 437
Query: 384 SNKTNIRFMEPLSMFCAMPPEYKG 407
+ + EP CA P + G
Sbjct: 438 QHLGLVGGEEPPR--CAGPGAHAG 459
Score = 108 bits (271), Expect = 1e-23
Identities = 99/385 (25%), Positives = 164/385 (42%), Gaps = 42/385 (10%)
Query: 14 VLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSD 73
VLGLL Q CP C C R + + D + +P+NL
Sbjct: 10 VLGLLRA-------QPFPCPPACKCVFRD-------AAQCSGGDVARISALGLPTNL--- 52
Query: 74 TQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITE 133
T +LL + L L S ++ + + ++L +L TL L N+IT
Sbjct: 53 THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112
Query: 134 MTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNL 193
+ L + L++L+++HN + I + F L NL L LN N+L + + F + NL
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
Query: 194 EILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVK 253
++L + N + + A L L+L L + L L +L L F+ N +
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 254 VPQLALQKVPNLKFLDLNK------------------------NPIHKIQEGDFKNMLRL 289
+ A ++PNL L L++ NP+ ++ F M L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
Query: 290 KELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNAL 349
+EL +N +L ++ A NL L L T +P+LS + + AF+ + L+ L L++N L
Sbjct: 293 QELWLNRT-QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL 351
Query: 350 NAIYQKTVESLPNLREISIHSNPLR 374
A+ + L LR++S+ N LR
Sbjct: 352 TALPDGLLRGLGKLRQVSLRRNRLR 376
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 112 bits (280), Expect = 1e-24
Identities = 107/417 (25%), Positives = 181/417 (43%), Gaps = 45/417 (10%)
Query: 23 TESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSN 82
TE NSEC VC P EA V+C+ L+LT+IP + T L L +N
Sbjct: 498 TEDYQLNSECNSDVVC-------PHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNN 550
Query: 83 NIA--KTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQ 140
I+ + ++L +L +++ S N + I++ ++ LHL NQ+ + +
Sbjct: 551 EISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFR 610
Query: 141 DLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGE 200
L L+ L + +N+IS I +F GL+N+ L L N++ + FD+ +L L +
Sbjct: 611 GLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLA 670
Query: 201 NP---------VIGILDMNFKPLAN--------LRSLVLAGMYLTDI-------PGNALV 236
NP + G L N LR + L + D G L
Sbjct: 671 NPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLP 730
Query: 237 GLDSLESLSFYD------NKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLK 290
+ + D NK ++ + K +LD N+ + Q FK L+L
Sbjct: 731 RPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFK-YLQLV 789
Query: 291 ELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALN 350
+L N ++ S+ + N+ +LT L + N L I LAF+ + +L L L+ N ++
Sbjct: 790 DLSNN---KISSLSNSSFTNMSQLTTLILSYN-ALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 351 AIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKG 407
+ + + +L ++I +NPL CDC + W+ S+ + EP CA P + +G
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPLYCDCHLRWL-SSWVKTGYKEPGIARCAGPQDMEG 901
Score = 95.5 bits (236), Expect = 2e-19
Identities = 100/424 (23%), Positives = 165/424 (38%), Gaps = 84/424 (19%)
Query: 26 SIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIA 85
++ + CP +C C VDC LT IP+NL + L+ N I
Sbjct: 276 TLSSGSCPAMCTCS-------------NGIVDCRGKGLTAIPANLPETMTEIRLELNGIK 322
Query: 86 KTVDELQQLFN-LTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSN 144
+ L +D S N I L L +L L N+IT++ L
Sbjct: 323 SIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYT 382
Query: 145 LQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVI 204
LQ L +N N+I+ I AF L+NL L L NK++ + F S ++ L + +NP
Sbjct: 383 LQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF- 441
Query: 205 GILDMNFKPLANL---RSLVLAGMYLTDIPGNALVGLDSLESLSF--------------- 246
I D N K LA+ + +G A + ++S F
Sbjct: 442 -ICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 500
Query: 247 ------------------YDNKLVKVPQLALQKVP-----NLKFLDLNKNPIHKIQ-EGD 282
+ +V+ L L K+P + L LN N I ++ G
Sbjct: 501 YQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGM 560
Query: 283 FKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESL 342
FK + LK++ ++N ++ ++ A + +++L T N +L I FR + L +L
Sbjct: 561 FKKLTHLKKINLSN-NKVSEIEDGAFEGAASVSELHLTAN-QLESIRSGMFRGLDGLRTL 618
Query: 343 MLNNNALNAIYQKTVESLPNLREISIH------------------------SNPLRCDCV 378
ML NN ++ I+ + L N+R +S++ +NP C+C
Sbjct: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678
Query: 379 IHWI 382
+ W+
Sbjct: 679 LAWL 682
Score = 92.0 bits (227), Expect = 2e-18
Identities = 109/469 (23%), Positives = 174/469 (37%), Gaps = 105/469 (22%)
Query: 30 SECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIA---- 85
S CP LC C TTVDC+ L IP N+ +T+ L L NNI
Sbjct: 32 SACPALCTCT-------------GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHK 78
Query: 86 ------KTVDELQQLFN---------------LTELDFSQNNFTNIKEVGLANLTQLTTL 124
K + LQ + N L L ++N + E+ N L+ L
Sbjct: 79 NDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRL 138
Query: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184
L EN I + + ++L+ L ++ NQIS I AF L+ L L LN+N + I
Sbjct: 139 DLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPV 198
Query: 185 RWFDSTPNLEILMIGEN------------------PVIGILDMNFKPLANLRSLVLA--- 223
F+ P L + N P IG+ P A+LR L +A
Sbjct: 199 SSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGP-ASLRGLNVAEVQ 257
Query: 224 ---------------------------------------GMYLTDIPGNALVGLDSLESL 244
G LT IP N +++ +
Sbjct: 258 KSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLP---ETMTEI 314
Query: 245 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304
N + +P A L+ +DL+ N I +I F+ + L L + ++ +
Sbjct: 315 RLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG-NKITDLP 373
Query: 305 RYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLR 364
R L L +L N K++ I AF+ + L L L +N + ++ + T SL ++
Sbjct: 374 RGVFGGLYTL-QLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ 432
Query: 365 EISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEV 413
+ + NP CDC + W+ ++ +E CA P ++ ++
Sbjct: 433 TLHLAQNPFICDCNLKWL-ADFLRTNPIETSGARCASPRRLANKRIGQI 480
Score = 87.4 bits (215), Expect = 4e-17
Identities = 65/209 (31%), Positives = 99/209 (47%), Gaps = 9/209 (4%)
Query: 216 NLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPI 275
N L L G +T I N GL L L +N++ V + A + L+ L LN+N +
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 276 HKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRS 335
H + E F+N L L ++ + ++ R A +L L+ N ++S I AFR+
Sbjct: 122 HMLPELLFQNNQALSRLDLSE-NAIQAIPRKAFRGATDLKNLQLDKN-QISCIEEGAFRA 179
Query: 336 VPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPL 395
+ LE L LNNN + I + +P LR +HSN L CDC + W++ +R +
Sbjct: 180 LRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQ---WLRQRPTI 236
Query: 396 SMF--CAMPPEYKGHQVKEVLIQDSSEQC 422
+F C+ P +G V EV Q S C
Sbjct: 237 GLFTQCSGPASLRGLNVAEV--QKSEFSC 263
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 110 bits (274), Expect = 6e-24
Identities = 101/394 (25%), Positives = 169/394 (42%), Gaps = 71/394 (18%)
Query: 22 LTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQS 81
LT S CP+ C CE V C +L IPS++S+ L L+
Sbjct: 24 LTMLSSAERGCPKGCRCE-------------GKMVYCESQKLQEIPSSISAGCLGLSLRY 70
Query: 82 NNIAKT-VDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQ 140
N++ K ++ + L LT L N+ +NI E + +L L L N+I+ + +
Sbjct: 71 NSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFR 130
Query: 141 DLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGE 200
++NL+ L +++NQ+ ++ + F GL+ LL LHL SN L+ I R F NLE+L +G
Sbjct: 131 PVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGY 190
Query: 201 NPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQ 260
N + + F + L+ L L + + L SL++L NK+ + Q
Sbjct: 191 NRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSW 250
Query: 261 KVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEAT 320
+L+ LDL+ N ++EA
Sbjct: 251 TWSSLQRLDLSGN------------------------------------------EIEAF 268
Query: 321 NNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCD---- 376
+ P + F+ VP L+ L L++N L I Q+ ++S +L +IS+ N C
Sbjct: 269 SGPSV-------FQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNIC 321
Query: 377 CVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQV 410
+++W+ S K + ++ CA P E +G V
Sbjct: 322 SLVNWLKSFKG----LRENTIICASPKELQGVNV 351
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 107 bits (268), Expect = 3e-23
Identities = 102/447 (22%), Positives = 178/447 (39%), Gaps = 71/447 (15%)
Query: 17 LLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQV 76
LL TSL + CP C C ++ F C+D L +P ++ T+
Sbjct: 7 LLWTSLLLLARPAQPCPMGCDCFVQEVF-------------CSDEELATVPLDIPPYTKN 53
Query: 77 LLL--------------QSNNIAKTV-----------DELQQLFNLTELDFSQNNFTNIK 111
++ + N+ K V D L L +L+ + ++F N+
Sbjct: 54 IIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLS 113
Query: 112 EVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLR 171
+NLT L L L N + + + Q L+ L+ L++ NQ+ + F L +L
Sbjct: 114 TNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKT 173
Query: 172 LHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIP 231
L+L N L + F +L+ L + N + G+ F L +L+ L L ++++P
Sbjct: 174 LNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233
Query: 232 GNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKF------------------------ 267
L LE L N + +P + NL F
Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVG 293
Query: 268 LDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSY 327
L L N + + EG F ++ L+ L + + + + +L EL KL +N L+
Sbjct: 294 LSLTHNQLETVAEGTFAHLSNLRSLML-SYNAITHLPAGIFRDLEELVKLYLGSN-NLTA 351
Query: 328 IHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDC----VIHWIN 383
+H F+++ LE L L+ N L + + ++ NL +++H NP +CDC + +W+
Sbjct: 352 LHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQ 411
Query: 384 SNKTNIRFMEPLSMFCAMPPEYKGHQV 410
+ + +CA P KG V
Sbjct: 412 QYTDRLL---NIQTYCAGPAYLKGQVV 435
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 105 bits (263), Expect = 1e-22
Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 40/356 (11%)
Query: 23 TESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSN 82
T + CP CVC + +V C+ LTR+P + TQ L L N
Sbjct: 70 TPGEAEGPACPAACVCSY-------DDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 122
Query: 83 NIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDL 142
N++ ++ NL+ L L+L+ Q+ + L L
Sbjct: 123 NLS-----------------------SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL 159
Query: 143 SNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENP 202
NL L++ NQ+ +++ FA L L L++N+L ++ F+ +L L +G N
Sbjct: 160 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 219
Query: 203 VIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV 262
+ + D F+ L +LR LVLAG L + GL L L N L + ++
Sbjct: 220 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 279
Query: 263 PNLKFLDLNKNPIHKIQEGDFKNM--LRLKELGINNMGELVSVDRYALDNLPELTKLEA- 319
P L+ L L++N I + G F + LR +L N + L+ D P L L
Sbjct: 280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE------DTFPGLLGLRVL 333
Query: 320 -TNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLR 374
++ ++ + F+ + LE L L +N + + +++ E L L +++ N L+
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ 389
Score = 100 bits (250), Expect = 4e-21
Identities = 88/323 (27%), Positives = 146/323 (45%), Gaps = 27/323 (8%)
Query: 77 LLLQSNNIAKTVDEL-QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMT 135
L+L N +A L L L ELD S+N IK L +L L+L+ N I +
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296
Query: 136 DYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEI 195
L L+ L ++HN+++ + F GL L L L+ N + + R F LE
Sbjct: 297 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 356
Query: 196 LMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVP 255
L +G N + + + +F+ L L L L L ++ A +GL ++ ++ N L +P
Sbjct: 357 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416
Query: 256 QLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELT 315
+ + + L L L + + +I+ F + L+ L + + G LV ++ +L L EL
Sbjct: 417 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG-LVGIEEQSLWGLAELL 475
Query: 316 KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNA----------------IYQKTVES 359
+L+ T+N HRL F+ + LE L+L+ N L + +E+
Sbjct: 476 ELDLTSNQLTHLPHRL-FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 534
Query: 360 LPN--------LREISIHSNPLR 374
LPN LR +S+ +N LR
Sbjct: 535 LPNSLLAPLGRLRYLSLRNNSLR 557
Score = 95.1 bits (235), Expect = 2e-19
Identities = 84/333 (25%), Positives = 143/333 (42%), Gaps = 25/333 (7%)
Query: 100 LDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTIS 159
LD S N + E L L L L N I + +DL L+EL + HN+I ++
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 160 AHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRS 219
+F GL L L L+ N+L+ + + F N+ ++ + N + + + F+ L L S
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 428
Query: 220 LVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQ 279
L L G L I + GL L L DN LV + + +L + L LDL N + +
Sbjct: 429 LHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP 488
Query: 280 EGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPAL 339
F+ + +L+ L + + L + AL L L+ ++N +L + + L
Sbjct: 489 HRLFQGLGKLEYL-LLSRNRLAELPADALGPLQRAFWLDVSHN-RLEALPNSLLAPLGRL 546
Query: 340 ESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWIN----SNKTNI-RFMEP 394
L L NN+L + P L + + NP C C + + N + + RF++
Sbjct: 547 RYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQA 602
Query: 395 L--------------SMFCAMPPEYKGHQVKEV 413
+ ++ CA PPE G ++++
Sbjct: 603 ICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 635
Score = 81.3 bits (199), Expect = 3e-15
Identities = 63/223 (28%), Positives = 96/223 (43%), Gaps = 1/223 (0%)
Query: 75 QVLLLQSNNIAKTVDE-LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITE 133
+VL L N IA + L L EL N + E L QL L L+ NQ+ E
Sbjct: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 390
Query: 134 MTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNL 193
+ L+N+ + ++ N + + F GL L LHL + L I F L
Sbjct: 391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 450
Query: 194 EILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVK 253
L + +N ++GI + + LA L L L LT +P GL LE L N+L +
Sbjct: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 510
Query: 254 VPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINN 296
+P AL + +LD++ N + + + RL+ L + N
Sbjct: 511 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN 553
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 105 bits (263), Expect = 1e-22
Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 40/356 (11%)
Query: 23 TESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSN 82
T + CP CVC + +V C+ LTR+P + TQ L L N
Sbjct: 32 TPGEAEGPACPAACVCSY-------DDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 84
Query: 83 NIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDL 142
N++ ++ NL+ L L+L+ Q+ + L L
Sbjct: 85 NLS-----------------------SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL 121
Query: 143 SNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENP 202
NL L++ NQ+ +++ FA L L L++N+L ++ F+ +L L +G N
Sbjct: 122 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 181
Query: 203 VIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV 262
+ + D F+ L +LR LVLAG L + GL L L N L + ++
Sbjct: 182 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 241
Query: 263 PNLKFLDLNKNPIHKIQEGDFKNM--LRLKELGINNMGELVSVDRYALDNLPELTKLEA- 319
P L+ L L++N I + G F + LR +L N + L+ D P L L
Sbjct: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE------DTFPGLLGLRVL 295
Query: 320 -TNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLR 374
++ ++ + F+ + LE L L +N + + +++ E L L +++ N L+
Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ 351
Score = 100 bits (250), Expect = 4e-21
Identities = 88/323 (27%), Positives = 146/323 (45%), Gaps = 27/323 (8%)
Query: 77 LLLQSNNIAKTVDEL-QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMT 135
L+L N +A L L L ELD S+N IK L +L L+L+ N I +
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 258
Query: 136 DYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEI 195
L L+ L ++HN+++ + F GL L L L+ N + + R F LE
Sbjct: 259 PGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEE 318
Query: 196 LMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVP 255
L +G N + + + +F+ L L L L L ++ A +GL ++ ++ N L +P
Sbjct: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378
Query: 256 QLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELT 315
+ + + L L L + + +I+ F + L+ L + + G LV ++ +L L EL
Sbjct: 379 EQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG-LVGIEEQSLWGLAELL 437
Query: 316 KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNA----------------IYQKTVES 359
+L+ T+N HRL F+ + LE L+L+ N L + +E+
Sbjct: 438 ELDLTSNQLTHLPHRL-FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 496
Query: 360 LPN--------LREISIHSNPLR 374
LPN LR +S+ +N LR
Sbjct: 497 LPNSLLAPLGRLRYLSLRNNSLR 519
Score = 95.1 bits (235), Expect = 2e-19
Identities = 84/333 (25%), Positives = 143/333 (42%), Gaps = 25/333 (7%)
Query: 100 LDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTIS 159
LD S N + E L L L L N I + +DL L+EL + HN+I ++
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 160 AHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRS 219
+F GL L L L+ N+L+ + + F N+ ++ + N + + + F+ L L S
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHS 390
Query: 220 LVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQ 279
L L G L I + GL L L DN LV + + +L + L LDL N + +
Sbjct: 391 LHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP 450
Query: 280 EGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPAL 339
F+ + +L+ L + + L + AL L L+ ++N +L + + L
Sbjct: 451 HRLFQGLGKLEYL-LLSRNRLAELPADALGPLQRAFWLDVSHN-RLEALPNSLLAPLGRL 508
Query: 340 ESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWIN----SNKTNI-RFMEP 394
L L NN+L + P L + + NP C C + + N + + RF++
Sbjct: 509 RYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQA 564
Query: 395 L--------------SMFCAMPPEYKGHQVKEV 413
+ ++ CA PPE G ++++
Sbjct: 565 ICEGDDCQPPAYTYNNITCASPPEVVGLDLRDL 597
Score = 81.3 bits (199), Expect = 3e-15
Identities = 63/223 (28%), Positives = 96/223 (43%), Gaps = 1/223 (0%)
Query: 75 QVLLLQSNNIAKTVDE-LQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITE 133
+VL L N IA + L L EL N + E L QL L L+ NQ+ E
Sbjct: 293 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 352
Query: 134 MTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNL 193
+ L+N+ + ++ N + + F GL L LHL + L I F L
Sbjct: 353 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 412
Query: 194 EILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVK 253
L + +N ++GI + + LA L L L LT +P GL LE L N+L +
Sbjct: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 472
Query: 254 VPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINN 296
+P AL + +LD++ N + + + RL+ L + N
Sbjct: 473 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN 515
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 105 bits (262), Expect = 1e-22
Identities = 82/286 (28%), Positives = 128/286 (44%), Gaps = 21/286 (7%)
Query: 19 MTSLTESSIQNSEC-----PQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSD 73
MTS + EC P C+C+ +DC++ L +PS +SS+
Sbjct: 82 MTSQYPFEAETPECLVGSVPVQCLCQ-------------GLELDCDETNLRAVPS-VSSN 127
Query: 74 TQVLLLQSNNIAKTV-DELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
+ LQ N I K D + +L +L N T+I L LT L+L N+IT
Sbjct: 128 VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT 187
Query: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKL-KVIDSRWFDSTP 191
+ +DL L+ L I N +S IS F GL +L+ L L +N L ++ D P
Sbjct: 188 FLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMP 247
Query: 192 NLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKL 251
L L + N + + ++ F +NL LV+ + + N L L+ L NK+
Sbjct: 248 RLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 307
Query: 252 VKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNM 297
+P L + + L L+L+ NPI KIQ F +++LK L + +
Sbjct: 308 ENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGI 353
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/269 (28%), Positives = 131/269 (48%), Gaps = 7/269 (2%)
Query: 99 ELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTI 158
ELD + N + V + +T + L+ N I ++ C ++ +LQ+LY+ +N+I++I
Sbjct: 110 ELDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSI 165
Query: 159 SAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLR 218
S +AF GL +L +L+L+ N++ + F+ LE L+I +N + I F L +L
Sbjct: 166 SIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLI 225
Query: 219 SLVLAGMYLTDIPGNALV-GLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHK 277
LVL LT +P L + L L N + + L NL L + KN I+
Sbjct: 226 LLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINH 285
Query: 278 IQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVP 337
+ E F + +L EL + + ++ ++ +L EL++L + NP + I F +
Sbjct: 286 LNENTFAPLQKLDELDLGS-NKIENLPPLIFKDLKELSQLNLSYNP-IQKIQANQFDYLV 343
Query: 338 ALESLMLNNNALNAIYQKTVESLPNLREI 366
L+SL L ++ I Q+ L NL I
Sbjct: 344 KLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/163 (26%), Positives = 78/163 (47%), Gaps = 5/163 (3%)
Query: 60 DLRLTRI--PSNLSSDTQVLLLQSNNIAKTVDE---LQQLFNLTELDFSQNNFTNIKEVG 114
D L+RI P+ ++ +LL+ NN+ + + Q + L LD N+ N++ +
Sbjct: 207 DNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 266
Query: 115 LANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHL 174
+ + LT L + +N+I + + L L EL + N+I + F LK L +L+L
Sbjct: 267 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNL 326
Query: 175 NSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANL 217
+ N ++ I + FD L+ L + + I F+PL NL
Sbjct: 327 SYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
Score = 54.7 bits (130), Expect = 3e-07
Identities = 46/172 (26%), Positives = 81/172 (47%), Gaps = 2/172 (1%)
Query: 77 LLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLA-NLTQLTTLHLEENQITEM 134
L+++ N++++ + L +L L N T + + L ++ +L L LE N I +
Sbjct: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNL 262
Query: 135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLE 194
+ SNL L + N+I+ ++ + FA L+ L L L SNK++ + F L
Sbjct: 263 RNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELS 322
Query: 195 ILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSF 246
L + NP+ I F L L+SL L G+ +++I L +L + F
Sbjct: 323 QLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF 374
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,640,292
Number of Sequences: 37866
Number of extensions: 1023066
Number of successful extensions: 7435
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 3034
Number of HSP's gapped (non-prelim): 2558
length of query: 716
length of database: 18,247,518
effective HSP length: 109
effective length of query: 607
effective length of database: 14,120,124
effective search space: 8570915268
effective search space used: 8570915268
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.