BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|150418009 transforming, acidic coiled-coil containing protein 2 isoform a [Homo sapiens] (2948 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|150418009 transforming, acidic coiled-coil containing protein... 5934 0.0 gi|45827755 transforming, acidic coiled-coil containing protein ... 2026 0.0 gi|11119414 transforming, acidic coiled-coil containing protein ... 1990 0.0 gi|45827753 transforming, acidic coiled-coil containing protein ... 1920 0.0 gi|170763517 transforming, acidic coiled-coil containing protein... 306 1e-82 gi|226246618 transforming, acidic coiled-coil containing protein... 300 1e-80 gi|170763519 transforming, acidic coiled-coil containing protein... 298 7e-80 gi|5454102 transforming, acidic coiled-coil containing protein 3... 211 9e-54 gi|163965366 nascent polypeptide-associated complex alpha subuni... 103 3e-21 gi|91982772 mucin 17 [Homo sapiens] 92 6e-18 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 91 2e-17 gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 91 2e-17 gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens] 90 3e-17 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 90 3e-17 gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens] 90 4e-17 gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 89 6e-17 gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 89 6e-17 gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 89 6e-17 gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 89 6e-17 gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 89 8e-17 gi|226437579 NAC alpha domain containing [Homo sapiens] 87 3e-16 gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens] 87 3e-16 gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 85 9e-16 gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] 84 2e-15 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 84 3e-15 gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho... 79 5e-14 gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho... 79 5e-14 gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho... 79 5e-14 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 78 1e-13 gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 78 1e-13 >gi|150418009 transforming, acidic coiled-coil containing protein 2 isoform a [Homo sapiens] Length = 2948 Score = 5934 bits (15395), Expect = 0.0 Identities = 2948/2948 (100%), Positives = 2948/2948 (100%) Query: 1 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCT 60 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCT Sbjct: 1 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCT 60 Query: 61 ASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEG 120 ASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEG Sbjct: 61 ASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEG 120 Query: 121 CLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPK 180 CLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPK Sbjct: 121 CLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPK 180 Query: 181 EEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESR 240 EEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESR Sbjct: 181 EEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESR 240 Query: 241 QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYL 300 QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYL Sbjct: 241 QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYL 300 Query: 301 TDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAG 360 TDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAG Sbjct: 301 TDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAG 360 Query: 361 GSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPAS 420 GSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPAS Sbjct: 361 GSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPAS 420 Query: 421 SLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE 480 SLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE Sbjct: 421 SLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE 480 Query: 481 HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPS 540 HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPS Sbjct: 481 HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPS 540 Query: 541 ESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQ 600 ESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQ Sbjct: 541 ESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQ 600 Query: 601 AFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLP 660 AFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLP Sbjct: 601 AFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLP 660 Query: 661 HKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEK 720 HKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEK Sbjct: 661 HKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEK 720 Query: 721 SDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPH 780 SDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPH Sbjct: 721 SDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPH 780 Query: 781 PPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETS 840 PPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETS Sbjct: 781 PPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETS 840 Query: 841 IFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSE 900 IFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSE Sbjct: 841 IFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSE 900 Query: 901 LQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSR 960 LQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSR Sbjct: 901 LQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSR 960 Query: 961 VSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEA 1020 VSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEA Sbjct: 961 VSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEA 1020 Query: 1021 ADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETE 1080 ADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETE Sbjct: 1021 ADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETE 1080 Query: 1081 ACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGD 1140 ACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGD Sbjct: 1081 ACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGD 1140 Query: 1141 PGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPAREL 1200 PGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPAREL Sbjct: 1141 PGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPAREL 1200 Query: 1201 GGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSAD 1260 GGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSAD Sbjct: 1201 GGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSAD 1260 Query: 1261 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE 1320 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE Sbjct: 1261 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE 1320 Query: 1321 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEP 1380 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEP Sbjct: 1321 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEP 1380 Query: 1381 SQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGK 1440 SQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGK Sbjct: 1381 SQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGK 1440 Query: 1441 DLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGP 1500 DLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGP Sbjct: 1441 DLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGP 1500 Query: 1501 AGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGL 1560 AGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGL Sbjct: 1501 AGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGL 1560 Query: 1561 PSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAH 1620 PSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAH Sbjct: 1561 PSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAH 1620 Query: 1621 TGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQST 1680 TGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQST Sbjct: 1621 TGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQST 1680 Query: 1681 PAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDL 1740 PAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDL Sbjct: 1681 PAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDL 1740 Query: 1741 VLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEP 1800 VLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEP Sbjct: 1741 VLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEP 1800 Query: 1801 DETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 DETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSP Sbjct: 1801 DETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVS 1920 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVS Sbjct: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVS 1920 Query: 1921 PSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPE 1980 PSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPE Sbjct: 1921 PSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPE 1980 Query: 1981 VSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDF 2040 VSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDF Sbjct: 1981 VSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDF 2040 Query: 2041 DNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSS 2100 DNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSS Sbjct: 2041 DNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSS 2100 Query: 2101 GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 2160 GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE Sbjct: 2101 GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 2160 Query: 2161 SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGG 2220 SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGG Sbjct: 2161 SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGG 2220 Query: 2221 GRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQ 2280 GRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQ Sbjct: 2221 GRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQ 2280 Query: 2281 ENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDID 2340 ENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDID Sbjct: 2281 ENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDID 2340 Query: 2341 KWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEI 2400 KWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEI Sbjct: 2341 KWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEI 2400 Query: 2401 PASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP 2460 PASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP Sbjct: 2401 PASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP 2460 Query: 2461 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 2520 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR Sbjct: 2461 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 2520 Query: 2521 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 2580 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE Sbjct: 2521 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 2580 Query: 2581 TEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFA 2640 TEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFA Sbjct: 2581 TEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFA 2640 Query: 2641 SADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIAL 2700 SADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIAL Sbjct: 2641 SADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIAL 2700 Query: 2701 ASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIIT 2760 ASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIIT Sbjct: 2701 ASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIIT 2760 Query: 2761 KEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ 2820 KEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ Sbjct: 2761 KEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ 2820 Query: 2821 ALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVH 2880 ALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVH Sbjct: 2821 ALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVH 2880 Query: 2881 AEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDE 2940 AEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDE Sbjct: 2881 AEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDE 2940 Query: 2941 LIAKMGKS 2948 LIAKMGKS Sbjct: 2941 LIAKMGKS 2948 >gi|45827755 transforming, acidic coiled-coil containing protein 2 isoform b [Homo sapiens] Length = 1094 Score = 2026 bits (5248), Expect = 0.0 Identities = 1044/1131 (92%), Positives = 1050/1131 (92%), Gaps = 54/1131 (4%) Query: 1818 TDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESP 1877 T R + PG S ++D P D SSPVADDIIQPAAPADLESP Sbjct: 18 TPRSAQPPGNSQNIKRKQQDTPGSPDH---------RDASSSPVADDIIQPAAPADLESP 68 Query: 1878 TLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCP 1937 TLAASSYHG D++ Q + A Sbjct: 69 TLAASSYHG--------DVVGQVSTDLIAQ------------------------------ 90 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV Sbjct: 91 -------RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 143 Query: 1998 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 2057 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS Sbjct: 144 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 203 Query: 2058 DAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGS 2117 DAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGS Sbjct: 204 DAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGS 263 Query: 2118 SSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTES 2177 SSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTES Sbjct: 264 SSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTES 323 Query: 2178 AKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLT 2237 AKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLT Sbjct: 324 AKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLT 383 Query: 2238 TAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKM 2297 TAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKM Sbjct: 384 TAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKM 443 Query: 2298 PLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQ 2357 PLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQ Sbjct: 444 PLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQ 503 Query: 2358 ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNK 2417 ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNK Sbjct: 504 ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNK 563 Query: 2418 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVT 2477 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVT Sbjct: 564 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVT 623 Query: 2478 NQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQ 2537 NQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQ Sbjct: 624 NQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQ 683 Query: 2538 DDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 2597 DDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR Sbjct: 684 DDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 743 Query: 2598 GLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCG 2657 GLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCG Sbjct: 744 GLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCG 803 Query: 2658 ALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTD 2717 ALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTD Sbjct: 804 ALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTD 863 Query: 2718 VSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRR 2777 VSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRR Sbjct: 864 VSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRR 923 Query: 2778 EVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFR 2837 EVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFR Sbjct: 924 EVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFR 983 Query: 2838 RYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRG 2897 RYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRG Sbjct: 984 RYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRG 1043 Query: 2898 KAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 2948 KAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS Sbjct: 1044 KAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 1094 Score = 117 bits (293), Expect = 2e-25 Identities = 179/679 (26%), Positives = 244/679 (35%), Gaps = 116/679 (17%) Query: 1 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSI---------- 50 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASS Sbjct: 1 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSSPVADDIIQPA 60 Query: 51 -----------------GSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGS 93 VG ++ S+ + +PE T P K P Sbjct: 61 APADLESPTLAASSYHGDVVGQVSTDLIAQRSSDSEEAFETPESTTPVKAPPAP------ 114 Query: 94 LLPSPPPSQEREHPSSSMPFAECPPE--GCLASPAAAPEDGPQTQSPRREPAPNAPGDIA 151 P PPP E S+ P PPE GC + P DGP++ S P + Sbjct: 115 --PPPPPEVIPEPEVSTQP----PPEEPGCGSETVPVP-DGPRSDSVEGSPFRPPSHSFS 167 Query: 152 AAFPAERD--SSTPYQ---EIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLR 206 A F ++ SS Y + + + +P+ K+ + +S P+ Sbjct: 168 AVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS 227 Query: 207 EPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVL 266 ++ D G S EA V + P+A + S+ Sbjct: 228 TLSRSLSLQASDFDGASSSGNPEA---------------VALAPDAYSTGSSSASSTLKR 272 Query: 267 EKSPLKPMAPIPQ---DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEA 323 K P P Q P +E Q E + L E L + A E Sbjct: 273 TKKPRPPSLKKKQTTKKPTETPPVKET-QQEPDEESLVPSGENLAS---ETKTESAKTEG 328 Query: 324 EVNAASQESCQQPVGAYLPHAELPWGLPS-PALVPEAGGSGKEALDTIDVQGHPQTGMRG 382 A +E+ +P A P A P S +VP A G G+ VQ P G R Sbjct: 329 PSPALLEETPLEP--AVGPKAACPLDSESAEGVVPPASGGGR-------VQNSPPVG-RK 378 Query: 383 TKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSR 442 T P L +PE +TP++ S A + ++ E SS Sbjct: 379 TLP---------------LTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSE-DKSSW 422 Query: 443 ESVSKAGMPVSADAAKEVVDAGL--VGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEH 500 ++ + P K V L +++ L + P P E P P +G + Sbjct: 423 DNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAE-PNDIPIAKGTY 481 Query: 501 LNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDST 560 + ++ P P + ++Q PK P +S P D V T Sbjct: 482 -----TFDIDKWDDPNFNPFSSTSKMQES------PKLPQQSYNFDPDTCD-ESVDPFKT 529 Query: 561 SPAVAKEGSRSPG--DSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKP 618 S S+SP + P EA GD N + + V K P Sbjct: 530 SSKTPSSPSKSPASFEIPASAMEANGV--DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSP 587 Query: 619 SSDAESRD-HPSSHSAQPP 636 SD S+D P++ PP Sbjct: 588 LSDPPSQDPTPAATPETPP 606 >gi|11119414 transforming, acidic coiled-coil containing protein 2 isoform d [Homo sapiens] Length = 1026 Score = 1990 bits (5155), Expect = 0.0 Identities = 1008/1018 (99%), Positives = 1009/1018 (99%), Gaps = 6/1018 (0%) Query: 1937 PDPAKDLS------RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP 1990 P PA DL+ SSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP Sbjct: 9 PAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP 68 Query: 1991 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ 2050 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ Sbjct: 69 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ 128 Query: 2051 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP 2110 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP Sbjct: 129 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP 188 Query: 2111 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA 2170 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA Sbjct: 189 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA 248 Query: 2171 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG 2230 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG Sbjct: 249 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG 308 Query: 2231 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG 2290 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG Sbjct: 309 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG 368 Query: 2291 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF 2350 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF Sbjct: 369 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF 428 Query: 2351 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV 2410 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV Sbjct: 429 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV 488 Query: 2411 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD 2470 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD Sbjct: 489 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD 548 Query: 2471 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK 2530 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK Sbjct: 549 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK 608 Query: 2531 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK 2590 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK Sbjct: 609 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK 668 Query: 2591 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA 2650 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA Sbjct: 669 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA 728 Query: 2651 HPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKR 2710 HPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKR Sbjct: 729 HPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKR 788 Query: 2711 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD 2770 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD Sbjct: 789 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD 848 Query: 2771 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK 2830 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK Sbjct: 849 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK 908 Query: 2831 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA 2890 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA Sbjct: 909 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA 968 Query: 2891 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 2948 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS Sbjct: 969 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 1026 Score = 36.6 bits (83), Expect = 0.38 Identities = 61/264 (23%), Positives = 87/264 (32%), Gaps = 45/264 (17%) Query: 2278 NQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAK----- 2332 +Q P P + + M + +TPE A P P P IP + Sbjct: 4 SQSLQPAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQP 63 Query: 2333 -------GTYTF---DIDKWDDPNFNPFSSTSKM------QESPKLPQQSYNFDPDTCDE 2376 G+ T D + D +PF S ++ P +YN D D E Sbjct: 64 PPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNI-E 122 Query: 2377 SVDPFKT------------------SSKTPSSP-SKSPASFEIPASAMEANGVDGDGLNK 2417 VD F+T T S P SKS S + A + +G G + Sbjct: 123 LVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPE 182 Query: 2418 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPS--QDPTPAATPETPPVISAVVHATDEEKLA 2475 T + + KR+ PPS + T ETPPV DEE L Sbjct: 183 AVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPV-KETQQEPDEESLV 241 Query: 2476 VTNQKWTCMTVDLEADKQDYPQPS 2499 + + T E+ K + P P+ Sbjct: 242 PSGENLASET-KTESAKTEGPSPA 264 Score = 35.8 bits (81), Expect = 0.64 Identities = 131/593 (22%), Positives = 195/593 (32%), Gaps = 90/593 (15%) Query: 61 ASES-SASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPE 119 ASE+ S+ + +PE T P K P P PPP E S+ P PPE Sbjct: 19 ASEAMSSDSEEAFETPESTTPVKAPPAP--------PPPPPEVIPEPEVSTQP----PPE 66 Query: 120 --GCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERD--SSTPYQ---EIAAVPS 172 GC + P DGP++ S P +A F ++ SS Y + + Sbjct: 67 EPGCGSETVPVP-DGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 125 Query: 173 AGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAG 232 + +P+ K+ + +S P+ ++ D G S EA Sbjct: 126 TFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEA-- 183 Query: 233 GFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQ---DPAPRASDRE 289 V + P+A + S+ K P P Q P +E Sbjct: 184 -------------VALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKE 230 Query: 290 RGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWG 349 Q E + L E L + A E A +E+ +P A P A P Sbjct: 231 T-QQEPDEESLVPSGENLAS---ETKTESAKTEGPSPALLEETPLEP--AVGPKAACPLD 284 Query: 350 LPS-PALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPS 408 S +VP A G G+ VQ P G R T P L +PE Sbjct: 285 SESAEGVVPPASGGGR-------VQNSPPVG-RKTLP---------------LTTAPEAG 321 Query: 409 LLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGL--V 466 +TP++ S A + ++ E SS ++ + P K V L Sbjct: 322 EVTPSDSGGQEDSPAKGLSVRLEFDYSE-DKSSWDNQQENPPPTKKIGKKPVAKMPLRRP 380 Query: 467 GLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEV 526 +++ L + P P E P P +G + + ++ P P + ++ Sbjct: 381 KMKKTPEKLDNTPASPPRSPAE-PNDIPIAKGTY-----TFDIDKWDDPNFNPFSSTSKM 434 Query: 527 QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPG--DSPGGKEEAPE 584 Q PK P +S P D V TS S+SP + P EA Sbjct: 435 QES------PKLPQQSYNFDPDTCD-ESVDPFKTSSKTPSSPSKSPASFEIPASAMEANG 487 Query: 585 PPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRD-HPSSHSAQPP 636 GD N + + V K P SD S+D P++ PP Sbjct: 488 V--DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP 538 >gi|45827753 transforming, acidic coiled-coil containing protein 2 isoform c [Homo sapiens] Length = 996 Score = 1920 bits (4974), Expect = 0.0 Identities = 978/1018 (96%), Positives = 979/1018 (96%), Gaps = 36/1018 (3%) Query: 1937 PDPAKDLS------RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP 1990 P PA DL+ SSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP Sbjct: 9 PAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEP 68 Query: 1991 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ 2050 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ Sbjct: 69 GCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQ 128 Query: 2051 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP 2110 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP Sbjct: 129 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAP 188 Query: 2111 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA 2170 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA Sbjct: 189 DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLA 248 Query: 2171 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG 2230 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG Sbjct: 249 SETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVG 308 Query: 2231 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG 2290 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG Sbjct: 309 RKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG 368 Query: 2291 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF 2350 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF Sbjct: 369 KKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPF 428 Query: 2351 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV 2410 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV Sbjct: 429 SSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGV 488 Query: 2411 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD 2470 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD Sbjct: 489 DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATD 548 Query: 2471 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK 2530 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK Sbjct: 549 EEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEK 608 Query: 2531 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK 2590 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK Sbjct: 609 IGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAK 668 Query: 2591 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA 2650 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA Sbjct: 669 NQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA 728 Query: 2651 HPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKR 2710 HPVSLCGALDYLEPDLAEKNPPLFAQKLQ R Sbjct: 729 HPVSLCGALDYLEPDLAEKNPPLFAQKLQ------------------------------R 758 Query: 2711 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD 2770 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD Sbjct: 759 EAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKD 818 Query: 2771 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK 2830 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK Sbjct: 819 KYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEK 878 Query: 2831 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA 2890 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA Sbjct: 879 SLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANA 938 Query: 2891 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 2948 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS Sbjct: 939 EIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 996 Score = 36.6 bits (83), Expect = 0.38 Identities = 61/264 (23%), Positives = 87/264 (32%), Gaps = 45/264 (17%) Query: 2278 NQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAK----- 2332 +Q P P + + M + +TPE A P P P IP + Sbjct: 4 SQSLQPAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQP 63 Query: 2333 -------GTYTF---DIDKWDDPNFNPFSSTSKM------QESPKLPQQSYNFDPDTCDE 2376 G+ T D + D +PF S ++ P +YN D D E Sbjct: 64 PPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNI-E 122 Query: 2377 SVDPFKT------------------SSKTPSSP-SKSPASFEIPASAMEANGVDGDGLNK 2417 VD F+T T S P SKS S + A + +G G + Sbjct: 123 LVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPE 182 Query: 2418 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPS--QDPTPAATPETPPVISAVVHATDEEKLA 2475 T + + KR+ PPS + T ETPPV DEE L Sbjct: 183 AVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPV-KETQQEPDEESLV 241 Query: 2476 VTNQKWTCMTVDLEADKQDYPQPS 2499 + + T E+ K + P P+ Sbjct: 242 PSGENLASET-KTESAKTEGPSPA 264 Score = 35.8 bits (81), Expect = 0.64 Identities = 131/593 (22%), Positives = 195/593 (32%), Gaps = 90/593 (15%) Query: 61 ASES-SASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPE 119 ASE+ S+ + +PE T P K P P PPP E S+ P PPE Sbjct: 19 ASEAMSSDSEEAFETPESTTPVKAPPAP--------PPPPPEVIPEPEVSTQP----PPE 66 Query: 120 --GCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERD--SSTPYQ---EIAAVPS 172 GC + P DGP++ S P +A F ++ SS Y + + Sbjct: 67 EPGCGSETVPVP-DGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 125 Query: 173 AGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAG 232 + +P+ K+ + +S P+ ++ D G S EA Sbjct: 126 TFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEA-- 183 Query: 233 GFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQ---DPAPRASDRE 289 V + P+A + S+ K P P Q P +E Sbjct: 184 -------------VALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKE 230 Query: 290 RGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWG 349 Q E + L E L + A E A +E+ +P A P A P Sbjct: 231 T-QQEPDEESLVPSGENLAS---ETKTESAKTEGPSPALLEETPLEP--AVGPKAACPLD 284 Query: 350 LPS-PALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPS 408 S +VP A G G+ VQ P G R T P L +PE Sbjct: 285 SESAEGVVPPASGGGR-------VQNSPPVG-RKTLP---------------LTTAPEAG 321 Query: 409 LLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGL--V 466 +TP++ S A + ++ E SS ++ + P K V L Sbjct: 322 EVTPSDSGGQEDSPAKGLSVRLEFDYSE-DKSSWDNQQENPPPTKKIGKKPVAKMPLRRP 380 Query: 467 GLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEV 526 +++ L + P P E P P +G + + ++ P P + ++ Sbjct: 381 KMKKTPEKLDNTPASPPRSPAE-PNDIPIAKGTY-----TFDIDKWDDPNFNPFSSTSKM 434 Query: 527 QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPG--DSPGGKEEAPE 584 Q PK P +S P D V TS S+SP + P EA Sbjct: 435 QES------PKLPQQSYNFDPDTCD-ESVDPFKTSSKTPSSPSKSPASFEIPASAMEANG 487 Query: 585 PPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRD-HPSSHSAQPP 636 GD N + + V K P SD S+D P++ PP Sbjct: 488 V--DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP 538 >gi|170763517 transforming, acidic coiled-coil containing protein 1 isoform 1 [Homo sapiens] Length = 805 Score = 306 bits (785), Expect = 1e-82 Identities = 279/891 (31%), Positives = 410/891 (46%), Gaps = 146/891 (16%) Query: 2091 ASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPT---ET 2147 A + + G+PE + S SS S T + P + + P+ Sbjct: 27 AGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAG 86 Query: 2148 PPVKETQ-QEPDEESLVPSGENLASETKTESAKTEGPSPAL-------LEETPLEPAVGP 2199 P K + QE DE+ + E +S+T ++ ++ E P A+ E P Sbjct: 87 PGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKI 146 Query: 2200 KAACPLDSESAEGVVPPASGGGRVQNS--PPVGRKTLPLTTAPEAGEVTPSDSGGQEDSP 2257 P E+ + A G + + V K LP + P D+ E Sbjct: 147 SIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSS---------PPDALQDEAMT 197 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS 2317 + V LE D + ++ E P + +KP +PLR+ K + +T A+ Sbjct: 198 EGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKP-KPVPLRK---KAIGGEFSDTNAA 253 Query: 2318 PPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPK-LPQQSYNFDPDTCDE 2376 +P + K +Y F ++ D+ N +P ++ Q+SP L + DT D Sbjct: 254 VEGTP-------LPKASYHFSPEELDE-NTSPLLGDARFQKSPPDLKETPGTLSSDTNDS 305 Query: 2377 SVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKS 2436 V+ ++ SSP K F +EA L + TP K + KS Sbjct: 306 GVE---LGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTP-KIQKDGISKS 361 Query: 2437 P----------KRSPLSDPPSQ-DPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMT 2485 + PLS S+ DP+ +P P S H+ + ++++ Sbjct: 362 AGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGS---HSVLQNSPPLSSEGSYHFD 418 Query: 2486 VDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQ 2545 D + D +P+ T + + F SPT G+ + + ++PKK Sbjct: 419 PDNFDESMDPFKPT---TTLTSSDFCSPT-----------------GNHVNEILESPKKA 458 Query: 2546 ALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAP--NQ 2603 L+ + C E ++ ++++ V ++ N+ Sbjct: 459 KSRLI-------------------TSGCKVKKHETQSLALDACSRDEGAVISQISDISNR 499 Query: 2604 ESHLQVPEKSS-----QKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGA 2658 + H EK + QK A G P E +E F ++ +S + H A Sbjct: 500 DGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY------FECSNVPVSTINH------A 547 Query: 2659 LDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDV 2718 E + ++ QK++E+ + +E+ +A V Sbjct: 548 FSSSEAGIEKET----CQKMEEDGSTVLGLLES--------------------SAEKAPV 583 Query: 2719 SISKTALYSRIGTAEVEKPA-GLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRR 2777 S+S E P G+ + D + L + R EIITKE E +EWK KYEE+R+ Sbjct: 584 SVSCGG----------ESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQ 633 Query: 2778 EVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFR 2837 EV+EMRKIVAEYEKTIAQMIEDEQR S ++ QQL +EKEQALADLNSVE+SL+DLFR Sbjct: 634 EVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFR 693 Query: 2838 RYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRG 2897 RYE +K VLEGF+KNEE LK+CAQ+YL+RVK+EEQRYQALK+HAEEKLD+AN EIAQVR Sbjct: 694 RYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRT 753 Query: 2898 KAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 2948 KA+ E AA A LRKEQ++V++LER L+QKN+EIEELTKICDELIAK+GK+ Sbjct: 754 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKT 804 Score = 127 bits (318), Expect = 2e-28 Identities = 172/657 (26%), Positives = 268/657 (40%), Gaps = 123/657 (18%) Query: 1924 PAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVST 1983 P GD E + + K LS SSDSE FETPE+ TP+++P P + P + Sbjct: 35 PEGDPEEEDSQA---ETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKS 91 Query: 1984 QPPPEE---------PGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSG 2034 Q E C S+T P E SHS +E + Sbjct: 92 QESQEADEQLVAEVVEKCSSKTCSKP-----SENEVPQQAIDSHSVKNFREEPEH----- 141 Query: 2035 TYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSL--SLQAS 2092 DF I +V F D+ + + T+ +S L S +LQ Sbjct: 142 ----DFSKISIVRPFSI---ETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDE 194 Query: 2093 DFDGASSSGNPEAVALAP-DAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVK 2151 S EA A A A ++ S + +KP+P L+KK Sbjct: 195 AMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKA------------ 242 Query: 2152 ETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAE 2211 + E +A EG TPL PKA+ E + Sbjct: 243 -----------------IGGEFSDTNAAVEG--------TPL-----PKASYHFSPEELD 272 Query: 2212 GVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSE 2271 P G R Q SPP ++T P T + + +DSG + ++ ++LEFD++E Sbjct: 273 ENTSPLLGDARFQKSPPDLKET-PGTLSSDT-----NDSGVELGEESRSSPLKLEFDFTE 326 Query: 2272 DKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEP--NDIP 2329 D + + ++ P +K+G+K + + PK++K + ++ P +P D P Sbjct: 327 DTGNIEARKALP---RKLGRKLGSTL---TPKIQKD----GISKSAGLEQPTDPVARDGP 376 Query: 2330 IAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQ-SYNFDPDTCDESVDPFKTSSKTP 2388 +++ + D +W+ P+FNPF S S +Q SP L + SY+FDPD DES+DPFK ++ Sbjct: 377 LSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLT 436 Query: 2389 SSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQ 2448 SS SP + + L P KK K+ L T +VKK +S D S+ Sbjct: 437 SSDFCSPTGNHV-----------NEILESP-KKAKSRLITSGCKVKKHETQSLALDACSR 484 Query: 2449 DPTPAATPETPPVISAVVHATDEEKLAVTN--QKWTCMTVDLEADKQ-DYPQPSDLSTFV 2505 D A + + + HATDEEKLA T+ QK V E ++ +Y + S++ Sbjct: 485 D-EGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVST 543 Query: 2506 NETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSS 2562 FSS ++ + ME+ GS++ L L+ +++++PV S Sbjct: 544 INHAFSSSEAGIEKET---CQKMEEDGSTV-----------LGLLESSAEKAPVSVS 586 Score = 37.0 bits (84), Expect = 0.29 Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 22/190 (11%) Query: 1872 ADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEA 1931 A +E L +SYH S + + ++ SP A S + +P + D ++ Sbjct: 252 AAVEGTPLPKASYH------FSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDS 305 Query: 1932 STPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPE 1988 + SRSS + F+ E T ++A A P + P++ + Sbjct: 306 GVELGEE-----SRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISK 360 Query: 1989 EPGCGSETVPVP-DGPRSD-SVEGSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFD 2041 G T PV DGP S S + P + S SF+ +V P++S G+Y+ D D Sbjct: 361 SAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPD 420 Query: 2042 NI-ELVDTFQ 2050 N E +D F+ Sbjct: 421 NFDESMDPFK 430 >gi|226246618 transforming, acidic coiled-coil containing protein 1 isoform 3 [Homo sapiens] Length = 610 Score = 300 bits (769), Expect = 1e-80 Identities = 237/676 (35%), Positives = 336/676 (49%), Gaps = 115/676 (17%) Query: 2293 PVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 2352 P + LR+PK +K S + E +P K +Y F ++ D+ N +P Sbjct: 29 PSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP--KASYHFSPEELDE-NTSPLLG 85 Query: 2353 TSKMQESPK-LPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVD 2411 ++ Q+SP L + DT D V+ ++ SSP K F +EA Sbjct: 86 DARFQKSPPDLKETPGTLSSDTNDSGVE---LGEESRSSPLKLEFDFTEDTGNIEARKAL 142 Query: 2412 GDGLNKPAKKKKTPLKTDTFRVKKSP----------KRSPLSDPPSQ-DPTPAATPETPP 2460 L + TP K + KS + PLS S+ DP+ +P P Sbjct: 143 PRKLGRKLGSTLTP-KIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNP 201 Query: 2461 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 2520 S H+ + ++++ D + D +P+ T + + F SPT Sbjct: 202 FGS---HSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPT---TTLTSSDFCSPT------ 249 Query: 2521 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 2580 G+ + + ++PKK L+ + C E Sbjct: 250 -----------GNHVNEILESPKKAKSRLI-------------------TSGCKVKKHET 279 Query: 2581 TEALVNTAAKNQHPVPRGLAP--NQESHLQVPEKSS-----QKELEAMGLGTPSEAIEIT 2633 ++ ++++ V ++ N++ H EK + QK A G P E +E Sbjct: 280 QSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY- 338 Query: 2634 APEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALK 2693 F ++ +S + H A E + ++ QK++E+ + +E+ Sbjct: 339 -----FECSNVPVSTINH------AFSSSEAGIEKET----CQKMEEDGSTVLGLLES-- 381 Query: 2694 LARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPA-GLLFQQPDLDSALQ 2752 +A VS+S E P G+ + D + L Sbjct: 382 ------------------SAEKAPVSVSCGG----------ESPLDGICLSESDKTAVLT 413 Query: 2753 IARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQ 2812 + R EIITKE E +EWK KYEE+R+EV+EMRKIVAEYEKTIAQMIEDEQR S ++ Q Sbjct: 414 LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473 Query: 2813 QLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQ 2872 QL +EKEQALADLNSVE+SL+DLFRRYE +K VLEGF+KNEE LK+CAQ+YL+RVK+EEQ Sbjct: 474 QLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQ 533 Query: 2873 RYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIE 2932 RYQALK+HAEEKLD+AN EIAQVR KA+ E AA A LRKEQ++V++LER L+QKN+EIE Sbjct: 534 RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIE 593 Query: 2933 ELTKICDELIAKMGKS 2948 ELTKICDELIAK+GK+ Sbjct: 594 ELTKICDELIAKLGKT 609 Score = 112 bits (279), Expect = 7e-24 Identities = 112/383 (29%), Positives = 183/383 (47%), Gaps = 54/383 (14%) Query: 2186 ALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEV 2245 A +E TPL PKA+ E + P G R Q SPP ++T P T + + Sbjct: 57 AAVEGTPL-----PKASYHFSPEELDENTSPLLGDARFQKSPPDLKET-PGTLSSDT--- 107 Query: 2246 TPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMK 2305 +DSG + ++ ++LEFD++ED + + ++ P +K+G+K + + PK++ Sbjct: 108 --NDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALP---RKLGRKLGSTLT---PKIQ 159 Query: 2306 KTPEKLDNTPASPPRSPAEP--NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLP 2363 K + ++ P +P D P+++ + D +W+ P+FNPF S S +Q SP L Sbjct: 160 KD----GISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLS 215 Query: 2364 QQ-SYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKK 2422 + SY+FDPD DES+DPFK ++ SS SP + + L P KK Sbjct: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHV-----------NEILESP-KKA 263 Query: 2423 KTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTN--QK 2480 K+ L T +VKK +S D S+D A + + + HATDEEKLA T+ QK Sbjct: 264 KSRLITSGCKVKKHETQSLALDACSRD-EGAVISQISDISNRDGHATDEEKLASTSCGQK 322 Query: 2481 WTCMTVDLEADKQ-DYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDD 2539 V E ++ +Y + S++ FSS ++ + ME+ GS++ Sbjct: 323 SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKET---CQKMEEDGSTV---- 375 Query: 2540 DAPKKQALYLMFDTSQESPVKSS 2562 L L+ +++++PV S Sbjct: 376 -------LGLLESSAEKAPVSVS 391 Score = 37.0 bits (84), Expect = 0.29 Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 22/190 (11%) Query: 1872 ADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEA 1931 A +E L +SYH S + + ++ SP A S + +P + D ++ Sbjct: 57 AAVEGTPLPKASYH------FSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDS 110 Query: 1932 STPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPE 1988 + SRSS + F+ E T ++A A P + P++ + Sbjct: 111 GVELGEE-----SRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISK 165 Query: 1989 EPGCGSETVPVP-DGPRSD-SVEGSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFD 2041 G T PV DGP S S + P + S SF+ +V P++S G+Y+ D D Sbjct: 166 SAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPD 225 Query: 2042 NI-ELVDTFQ 2050 N E +D F+ Sbjct: 226 NFDESMDPFK 235 >gi|170763519 transforming, acidic coiled-coil containing protein 1 isoform 2 [Homo sapiens] Length = 395 Score = 298 bits (762), Expect = 7e-80 Identities = 149/210 (70%), Positives = 179/210 (85%) Query: 2739 GLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIE 2798 G+ + D + L + R EIITKE E +EWK KYEE+R+EV+EMRKIVAEYEKTIAQMIE Sbjct: 185 GICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIE 244 Query: 2799 DEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKR 2858 DEQR S ++ QQL +EKEQALADLNSVE+SL+DLFRRYE +K VLEGF+KNEE LK+ Sbjct: 245 DEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKK 304 Query: 2859 CAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVD 2918 CAQ+YL+RVK+EEQRYQALK+HAEEKLD+AN EIAQVR KA+ E AA A LRKEQ++V+ Sbjct: 305 CAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE 364 Query: 2919 ALERTLEQKNKEIEELTKICDELIAKMGKS 2948 +LER L+QKN+EIEELTKICDELIAK+GK+ Sbjct: 365 SLERALQQKNQEIEELTKICDELIAKLGKT 394 >gi|5454102 transforming, acidic coiled-coil containing protein 3 [Homo sapiens] Length = 838 Score = 211 bits (537), Expect = 9e-54 Identities = 107/208 (51%), Positives = 151/208 (72%), Gaps = 7/208 (3%) Query: 2740 LLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIED 2799 L + Q DLD+ ++ + E E + + EE + +E+ KI+ +E+ + Q +E+ Sbjct: 637 LQYSQKDLDAVVKAT-------QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689 Query: 2800 EQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRC 2859 Q++K +S +Q+++ EK+Q DLNS+EKS +DLF+R+EK KEV+EG+RKNEE LK+C Sbjct: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749 Query: 2860 AQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDA 2919 ++YL+R+ +E QRYQALK HAEEKL AN EIAQVR KAQ E A QASLRKEQ+R+ + Sbjct: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809 Query: 2920 LERTLEQKNKEIEELTKICDELIAKMGK 2947 LE+T+EQK KE EELT+ICD+LI+KM K Sbjct: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837 Score = 102 bits (254), Expect = 6e-21 Identities = 192/868 (22%), Positives = 329/868 (37%), Gaps = 177/868 (20%) Query: 2054 PRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAY 2113 P + +NQ+ K+T + L AS G+ SS ALA Sbjct: 95 PVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDC 154 Query: 2114 STGSSSASSTLKRTKKPRPPSLKKKQTTKKPTET-------PPVKETQQEP-----DEES 2161 S+ S S S+ + P S +Q ++ + P ET ++P ++ Sbjct: 155 SSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKA 214 Query: 2162 LVPSGENLASETKTESAKTEGP------SPALLEETPLEPAVGPKAAC---PLDSESAEG 2212 P G + +T E +PA + +P P PK AC PL E Sbjct: 215 ETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSP--PGAIPKEACGGAPLQGLPGEA 272 Query: 2213 VVPPASGGGRVQNSPPVGRKTL-------PLTTAP-------EAGEVTPSD--SGGQEDS 2256 + PA G V P G +TL P +TAP A ++P + + GQ S Sbjct: 273 LGCPAGVGTPV---PADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMAS 329 Query: 2257 PAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRP--KMKKTPEKLDNT 2314 ++ V+LEFD S+ +S + PP +++G++ K PLR+ + +K P++++ Sbjct: 330 SSRSGPVKLEFDVSDGATS-----KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEED 384 Query: 2315 PASPPRSPA-EPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDT 2373 RS A E +P ++G+Y D DK DDPNF PF +K Sbjct: 385 DG---RSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTK----------------SG 425 Query: 2374 CDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRV 2433 C E+ P ++P + PA+ ++ A PA ++ P Sbjct: 426 CSEAQPP-----ESPETRLGQPAAEQLHAG--------------PATEEPGPCL------ 460 Query: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE-ADK 2492 SQ A+ +TP V A T E K N T + ++ Sbjct: 461 -------------SQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEP 507 Query: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552 Q + + E F P E L E++Y+E+ G+S + A +KQ+LYL FD Sbjct: 508 VPTHQQGQPALELKEESFRDPAEVLG--TGAEVDYLEQFGTS-SFKESALRKQSLYLKFD 564 Query: 2553 -TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPE 2611 ++SP + PV S + N+ P R P Sbjct: 565 PLLRDSPGRPVPVATETS----------------SMHGANETPSGR------------PR 596 Query: 2612 KSSQKELEAMG---LGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAE 2668 ++ E + +G + P + AP G P+S +D L+ ++ Sbjct: 597 EAKLVEFDFLGALDIPVPGPPPGVPAPGGP-------------PLSTGPIVDLLQ--YSQ 641 Query: 2669 KNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSR 2728 K+ + QEE R E L + + L D E + + K Sbjct: 642 KDLDAVVKATQEENRELRSRCEELH-GKNLELG--KIMDRFEEVVYQAMEEVQK---QKE 695 Query: 2729 IGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAE 2788 + AE++K +L ++ L + L + + K+ E R+ ++K V + Sbjct: 696 LSKAEIQK---VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752 Query: 2789 YEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ-------ALADLNSVEKSLADLFRRYEK 2841 Y +A++ ++ QR +++ ++L L E+ A A+ +++ SL R + Sbjct: 753 Y---LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809 Query: 2842 MKEVLEGFRKNEEVLKRCAQEYLSRVKK 2869 +++ +E K E L R + +S+++K Sbjct: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837 Score = 42.0 bits (97), Expect = 0.009 Identities = 107/438 (24%), Positives = 153/438 (34%), Gaps = 102/438 (23%) Query: 1473 EKKQQLAGE--AEISHLALQDP--ASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLRE- 1527 ++ QQL E A+ +H LQ P A LLG A P G G P L + Sbjct: 100 KENQQLIKEVDAKTTHGILQKPVEADTDLLGDAS-------PAFGSGSSSESGPGALADL 152 Query: 1528 --DERPEGPGAAWPGL--EGQAYSQLERSRQELASGLP-----SPAA-TQELPVERAAAF 1577 + PG++ + G+ E++ +E S +PA+ T E P R + Sbjct: 153 DCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPC-RTESQ 211 Query: 1578 QVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQ 1637 A HG E + P G + + HG T PG +P+ C +P Sbjct: 212 HKAETPHGAEEECKAETPHGAEEE------CRHGGVCAPAAVATSPPGAIPKEACGGAP- 264 Query: 1638 REVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGK 1697 L L GE G AG+ A G Q+ T T Sbjct: 265 ---------------LQGLPGEAL-GCPAGVGTPVPADGTQTLTCAHTSAPESTAPTNHL 308 Query: 1698 VAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPG 1757 VAG A +TLS E A+G + A ++R+ G + L D A S +AP Sbjct: 309 VAGRA------MTLSPQEE--VAAGQM--ASSSRS-----GPVKLEFDVSDGATSKRAPP 353 Query: 1758 MEGTAALHGDSPA----------RPQQAKEQPG-----PERPIPAGDGKVCVS------- 1795 G P PQ+ +E G + P+PA G + Sbjct: 354 PRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDP 413 Query: 1796 -------------SPPEPDETHDPKLQHLAPEELHTDRESPRPGPSM---LPSVPKKDAP 1839 S +P E+ + +L A E+LH + PGP + L S +D P Sbjct: 414 NFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTP 473 Query: 1840 RVMDKVTSDETRGAEGTE 1857 V + ET AE E Sbjct: 474 VVQ---LAAETPTAESKE 488 Score = 40.0 bits (92), Expect = 0.034 Identities = 118/542 (21%), Positives = 179/542 (33%), Gaps = 101/542 (18%) Query: 21 SAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEP 80 S+Q PG+S+N GSP+ ++ S L T + + DPC TE Sbjct: 157 SSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLE-DPCR-----TES 210 Query: 81 RKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRR 140 + + G E P E E C G + +PAA Sbjct: 211 QHKAETPHGAEEECKAETPHGAEEE----------CR-HGGVCAPAAV------------ 247 Query: 141 EPAPNAPGDIAAAFPAERDSSTPYQ----EIAAVPSAGRERQPKEEGQKSSFSFSSGIDQ 196 A + PG A P E P Q E P+ P + Q + + +S + Sbjct: 248 --ATSPPG----AIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPES 301 Query: 197 SPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAA 256 + + + M S ++E A G + SR G ++ A + Sbjct: 302 TAPTNHLVAGRAMTL-------------SPQEEVAAGQMASSSRSGPVKLEFDVSDGATS 348 Query: 257 QQGTESSAVLEKSPLKP---MAPIPQDPAPR---ASDRERGQGEAPPQYLT--------D 302 ++ + E+S LKP A + Q AP+ D G GE PP + D Sbjct: 349 KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWD 408 Query: 303 DLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGS 362 ++ EA+ + + QP L HA P P L + + Sbjct: 409 KMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQL-HAGPATEEPGPCLSQQLHSA 467 Query: 363 GKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPT-EEAHPASS 421 E DT VQ +T +K A LP S S PT ++ PA Sbjct: 468 SAE--DTPVVQLAAETPTAESKER------ALNSASTSLPTSCPGSEPVPTHQQGQPALE 519 Query: 422 L--ASF--PAAQIPIA-----VEEPGSSS--RESVSKAGMPVSADAAKEVVDAGLVGLER 470 L SF PA + +E+ G+SS ++ K + + D V + Sbjct: 520 LKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVAT 579 Query: 471 QVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGA 530 + S + E P G P E G + ++ PPP +P PG Sbjct: 580 ETSSMHGANETPSGRPREAKLVEFDFLG-------ALDIPVPGPPPGVP-------APGG 625 Query: 531 PP 532 PP Sbjct: 626 PP 627 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 103 bits (256), Expect = 3e-21 Identities = 343/1642 (20%), Positives = 506/1642 (30%), Gaps = 315/1642 (19%) Query: 1264 PGESPCPVGEPPLALENAASLKLFAG-------SLAPLLQPGAAGG--EIPAVQ-ASSGS 1313 P ES P G P + ++ A SLAP P G +P V AS Sbjct: 649 PLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENC 708 Query: 1314 PKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGS 1373 P A + + + L P + K + A T PG D T Sbjct: 709 PVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKV--------DGISHTSAL 760 Query: 1374 MERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGA 1433 P + P + + SS+ TLT D + P +K A Sbjct: 761 APVASSPKECPTEDSGASATASSK--GTLTYLADSPSPLGVSVSPQTK---RPPTKKGSA 815 Query: 1434 GRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEI--SHLALQD 1491 G +L+ P+ P V+ + LP Q K + S Sbjct: 816 GPDTPIGNLSSPVSP---------VEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866 Query: 1492 PASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLER 1551 P++ L P G+T LP P +E P A P L + S + Sbjct: 867 PSAVTPLSPKGVT----LPPKETPTPSVVNLPFPKEGPATPAPKQA-PALSMTSSSPKKA 921 Query: 1552 SRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHG 1611 G+P+ + + P AA P G A PS K A P Sbjct: 922 RATPAPKGIPASPSPKGAPTPPAAT---PPSPKGGPAT-----PSPKWAPTPPAATPPSP 973 Query: 1612 EDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEM 1671 + GP + G P P + PSP+ P T G P VT Sbjct: 974 KGGPATPSPKGAP--TPPAATPPSPK----------GGPATPSPKGAPTPPAVT------ 1015 Query: 1672 RNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTR 1731 P P G A TP G A T A+ P+ Sbjct: 1016 ---------PPSPKGSPAATPFPKG-----------------ASTPPAATPPSPKGSPAA 1049 Query: 1732 TFSVVAGDLVLP-GSCQDPACSDKAP-GMEGTAALHGDSPARPQQAKEQP--GPERPIPA 1787 T LP G+ PA + +P G T +L G +P P P GP P P Sbjct: 1050 T--------PLPKGAPTTPAATLPSPKGGPATPSLKG-APTPPAATPPSPKGGPATPSPK 1100 Query: 1788 GDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTS 1847 G ++PP P AP SP+ G L + P K AP Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGG---LATPPPKGAPTT------ 1151 Query: 1848 DETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAH 1907 T SP A P +PT A++ G + +PAA Sbjct: 1152 -----PAATPPSPKGG----LATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT- 1201 Query: 1908 AGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPA 1967 PPS + +PS A+TP P P L+ + S + T + TP Sbjct: 1202 ---PPSPKGGLATPSPKGAPTTPAATP--PSPKGGLA--TPSPKGAPTTPAATPPSPKGG 1254 Query: 1968 PPPPPPEVIPEPEVSTQP-------PPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSF 2020 P PPP+ P P +T P P G + V P P+ P P+ Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPT--- 1311 Query: 2021 SAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISK 2080 P A+ + +G T P + Sbjct: 1312 ---------------------------------PPAATPPSPKGSPGTPPPKGAPTPPAV 1338 Query: 2081 STLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQT 2140 + S G P A P SS T +K+ P Sbjct: 1339 TP--------------PSPKGTPTLPATTP------SSKGGPTTPSSKEGPTPPAATPSH 1378 Query: 2141 TKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPK 2200 P TPP P +P S K + SPA++ PL P P Sbjct: 1379 KGGPAMTPP------SPKRGPAIP------------SPKGDPTSPAVI---PLSPKKAP- 1416 Query: 2201 AACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKG 2260 A P+ + EG P+ G PV K P T+AP+ G TPS S G PA Sbjct: 1417 -ATPV---TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPS-SKGDPTLPA-- 1469 Query: 2261 LSVRLEFDYSEDKSSWDNQQENPPPTKKIG------KKPVAKMPLRRPKM----KKTPEK 2310 + PP K++ K P P+ P + +P++ Sbjct: 1470 --------------VTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKE 1515 Query: 2311 LDNTPASPPRSPAEPNDIPIAKGTYTFDIDK------------------WDDPNFNPFSS 2352 + TP+S R P P ++K T K P P + Sbjct: 1516 VPATPSS-RRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATP 1574 Query: 2353 TSKMQES-PKLPQQSYNFDPDTCDESVDPFKTS---SKTPSSPSKSPASFEIPASAMEAN 2408 +SK S P + +Y P + + P TS + P+ P+ +P S E + Sbjct: 1575 SSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPK 1634 Query: 2409 GVDGDGLNKPAKKKKTPLKTDTFRVK------KSPKRSPLSDPPS--QDPTPAATPETPP 2460 G P+ K +P + K ++ K P P+ ++ A PE+ P Sbjct: 1635 GTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTP 1694 Query: 2461 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 2520 +I+A + K + C P PS + +P L + Sbjct: 1695 IITAPTRKGPQTKKSSATSPPIC------------PDPSAKNGSKGPLSTVAPAPLLPVQ 1742 Query: 2521 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 2580 K S P+ AP + + V P S S P S Sbjct: 1743 KDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPL 1802 Query: 2581 TEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKEL------EAMGLGTPSEAIEITA 2634 + V T Q +P ES + + + EL E + G P +++ + Sbjct: 1803 APSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNM 1862 Query: 2635 PEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQ-KLQEELEFAIMRIEALK 2693 P A PV+ E D E P L Q Q + A + A Sbjct: 1863 PTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEI 1922 Query: 2694 LARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEV--EKPAGLLF--QQPDLDS 2749 ++ A +S + K A +SK L G V K +LF +PD+ Sbjct: 1923 DEEPVSKAKQSRSEKKARKA------MSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYK 1976 Query: 2750 ALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAE-----YEKTIAQMIEDEQREK 2804 + + I+ E ++ +D ++++ E K+ E E T +++E E+ Sbjct: 1977 S-PASDTYIVFGEAKI---EDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE 2032 Query: 2805 SVSHQTVQQLVLEKEQALADLN 2826 V V+ +E + A+++ Sbjct: 2033 EVDETGVEVKDIELVMSQANVS 2054 Score = 100 bits (250), Expect = 2e-20 Identities = 255/1118 (22%), Positives = 364/1118 (32%), Gaps = 175/1118 (15%) Query: 4 ENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDH-----RDASSIGSVGL--- 55 ENS S S T S PP + + TP SP ++ + V L Sbjct: 838 ENSLSFQGSKDSPATTHSPTPP-SPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFP 896 Query: 56 --GGFCTASESSASLDPCLVSPEVTEPRKDPQG---ARGPEGSLLP--SPPPSQEREHPS 108 G A + + +L SP+ P+G + P+G+ P + PPS + + Sbjct: 897 KEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPAT 956 Query: 109 SSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDS-STPYQEI 167 S +A PP A+ +P+ GP T SP+ P P A A P+ + +TP + Sbjct: 957 PSPKWAPTPP----AATPPSPKGGPATPSPKGAPTPPA-----ATPPSPKGGPATPSPKG 1007 Query: 168 AAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPV-PLREPMKAPLCGEGDQPGGFESQ 226 A P A PK G ++ F G P +P P P PL P G + Sbjct: 1008 APTPPAVTPPSPK--GSPAATPFPKGASTPPAATPPSPKGSPAATPL------PKGAPTT 1059 Query: 227 EKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPR-- 284 A P + S++ P PAA + PM P P+P+ Sbjct: 1060 P---AATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGG 1116 Query: 285 -ASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPH 343 A+ +G P A P G A A + + P Sbjct: 1117 LATPPHKGAPTTP------------AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA 1164 Query: 344 AELPWGLPS-PALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP 402 P G P+ PA P S K L T +G P T P Sbjct: 1165 TPPPKGAPTTPAATPP---SPKGGLATPSPKGAPTT-------------------PAATP 1202 Query: 403 VSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVD 462 SP+ L TP+ + P + A+ P+ + +A P + + P A Sbjct: 1203 PSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPP--- 1259 Query: 463 AGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQ 522 P+G P A P +G P V PP PK Sbjct: 1260 -------------------PKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGG 1300 Query: 523 SHEVQP-GAPPPPLPKAPSESARGPPG--PTDGAKVHEDSTSPA-------VAKEGSRSP 572 P GAP PP P S +G PG P GA T P+ A S Sbjct: 1301 PATSPPKGAPTPPAATPP--SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKG 1358 Query: 573 GDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS 632 G + +E P PP P + G S KR P + + P+S A P Sbjct: 1359 GPTTPSSKEGPTPP-AATPSHKGGPAMTPPSPKRGPAIPSPK-GDPTSPAVIPLSPKKAP 1416 Query: 633 AQP-PRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGS 691 A P R+G A + G + A S P P G+PT+P A+ S Sbjct: 1417 ATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLP--AVTPPS 1474 Query: 692 GLQPKCPDTLQSREG----------LGRMESFLTLESEKSDFPPTPVAEVAPKAQEGEST 741 +P P + + +G + S + P TP + P A Sbjct: 1475 PKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLL 1534 Query: 742 LEIRKMGSCDGEGL----LTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALI 797 + E L +T P + PA ++ P P + ++ +T Sbjct: 1535 SKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKE-----APATPSSKEASSPPAVT--- 1586 Query: 798 LDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKE 857 +G PS P E I A + E P+ P K A P G Sbjct: 1587 -PSTYKGAPS-PKELLIPPAVTS--PSPKEAPTPPAVTPPSPE-----KGPATPAPKGTP 1637 Query: 858 TSP--SHPGFKDQGADSSQIHVPV---EPQEDNNLPTHGGQEQALGSELQSQLPKGTLSD 912 TSP + KD + + + PQ LP G AL L + P+ T Sbjct: 1638 TSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKG-PTALKEVLVAPAPESTPII 1696 Query: 913 TPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSP-PAADVLKD 971 T + +SS T P+ + G K G S V+P P V KD Sbjct: 1697 TAPTRKGPQTKKSSATSPPICPDPSAKN----GSK--------GPLSTVAPAPLLPVQKD 1744 Query: 972 FSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLS 1031 S K+ + +GP ++ A + E+ + AS +A P+ Sbjct: 1745 SSKTA--KGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPV---- 1798 Query: 1032 KREMASGNTGEAPPCQ---PDSVALLDAVPCLPALAPA 1066 +A PP Q P S L+ P P LAPA Sbjct: 1799 SLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKP-LAPA 1835 Score = 97.1 bits (240), Expect = 2e-19 Identities = 317/1383 (22%), Positives = 443/1383 (32%), Gaps = 261/1383 (18%) Query: 1036 ASGNTGEAPP----CQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQ 1091 AS N AP C P +A L P +P P SP + P P T+ D Sbjct: 704 ASENCPVAPSPQNTCAP--LATLVLAPEIPKSVP-SPSLPPAGTPPGTKKVDGISH-TSA 759 Query: 1092 PVPAPQQKMEC-----WATSDAESPKLLASFPSAGEQGGEAGAAETG------GSAGAGD 1140 P EC A++ A S L + G + + +T GSAG Sbjct: 760 LAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDT 819 Query: 1141 P-GKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARE 1199 P G +P P EA+ L G + S + A A+ P Sbjct: 820 PIGNLSSPVSPVEASF----LPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSP 875 Query: 1200 LG-GIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSS 1258 G +P + +P PKE GP A P L + S++ + A + Sbjct: 876 KGVTLPPKETPTPSVVNLPFPKE----GPATPAPKQAPALSMTSSSPKKARATPAPKGIP 931 Query: 1259 ADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKART 1318 A P G P PP A+ P P + G PA + G+P Sbjct: 932 ASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGG-PATPSPKGAPTPPA 990 Query: 1319 TEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGA-------GAKASGEGMAGDAAGETE 1371 P KG AT K A P A G+ A+ G + Sbjct: 991 ATPP------------SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAA 1038 Query: 1372 GSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKA 1431 G P+ P G T + + + G P + P A P K Sbjct: 1039 TPPSPKGSPAATPL--PKGAPTTPAATLPSPKGGP----ATPSLKGAPTPPAATPPSPKG 1092 Query: 1432 G----AGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHL 1487 G + + A P P+ L PP P PA K LA Sbjct: 1093 GPATPSPKGAPMPPAATPPSPKGGLATPPHKGA---PTTPAATPPSPKGGLATPPPKG-- 1147 Query: 1488 ALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYS 1547 A PA+ GL P G A PP+ P+G G A P +G + Sbjct: 1148 APTTPAATPPSPKGGLA---TPPPKGAPTTPAATPPS------PKG-GLATPSPKGAPTT 1197 Query: 1548 QLERSRQELASGLPSPAATQELPVERAAAFQVA---PHSHGEEAVAQDRIPSGKQHQETS 1604 A+ PSP P + A A P G A PS K T Sbjct: 1198 P--------AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT-----PSPKGAPTTP 1244 Query: 1605 ACDSPHGEDGPGDFAHTGVPGHVPRSTCAPS-------------PQREVLTVPEANSEPW 1651 A P + GP G P P + PS P V+T P P Sbjct: 1245 AATPPSPKGGPATPPPKGAP--TPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPA 1302 Query: 1652 TLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITL 1711 T G P T + G+ TP PP G A TP Sbjct: 1303 TSPPKGAPTPPAATP-----PSPKGSPGTP-PPKG--APTP------------------- 1335 Query: 1712 STAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPAR 1771 A T G TT + G P S + P P +G A+ SP R Sbjct: 1336 -PAVTPPSPKGTPTLPATTPSSK---GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKR 1391 Query: 1772 PQQAKEQPGPERPIPAGDGKVCVSSPPEPDET-HDPKLQHLAPEELHTDRESPRPGPSML 1830 GP P P GD P P + P + A D P P L Sbjct: 1392 --------GPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSL 1443 Query: 1831 PSVPKKDAPR------------VMDKVTSDETRGAE-----GTESSPVADDIIQPAAPAD 1873 P AP+ + VT + T SSP PA PA Sbjct: 1444 KKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKK----APATPAP 1499 Query: 1874 LESPTL------------AASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSP 1921 + +PTL A S D + +T L ++ + A L P A + SP Sbjct: 1500 MGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMT-VPSP 1558 Query: 1922 SAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEV 1981 TP+ P P K+ + S+EA +P + TP A P P E++ P V Sbjct: 1559 K---------KTPAIPTP-KEAPATPSSKEA-SSPPAVTPSTYKGA--PSPKELLIPPAV 1605 Query: 1982 STQPPPEEPGCGSETVPVPD-GPRSDSVEGSPFRPP------------SHSFSAVFDEDK 2028 ++ P E P + T P P+ GP + + +G+P PP S + Sbjct: 1606 TSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATV 1665 Query: 2029 PIASSGTYNLDFDNIELVDTFQTLEPRAS---DAKNQEGKVNTRRKSTDSVPI------- 2078 P AS G L + P ++ A ++G T++ S S PI Sbjct: 1666 PQASKG-LPAKKGPTALKEVLVAPAPESTPIITAPTRKGP-QTKKSSATSPPICPDPSAK 1723 Query: 2079 --SKSTLSR-----SLSLQ---ASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTK 2128 SK LS L +Q + G +S +P+ P++ ++ +A++ K Sbjct: 1724 NGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLP 1783 Query: 2129 KPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALL 2188 KP S+ +PPV +L P + L S SP L+ Sbjct: 1784 KPESASV-------SAAPSPPVSLPLAPSPVPTLPPKQQFLPS------------SPGLV 1824 Query: 2189 EETPLEPAVGPKAACPLDSESAEGVVP--PASGGGRVQ----NSPPVGRKTLPLTTAPEA 2242 E+P +P P D + ++P P SGG Q N P +P+ T Sbjct: 1825 LESPSKP------LAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAK 1878 Query: 2243 GEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRP 2302 VT ++ G +S + LE +D + QQ +I ++PV+K R Sbjct: 1879 QPVTKNNKGSGTESDSDESVPELE---EQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRS 1935 Query: 2303 KMK 2305 + K Sbjct: 1936 EKK 1938 Score = 80.9 bits (198), Expect = 2e-14 Identities = 353/1667 (21%), Positives = 540/1667 (32%), Gaps = 315/1667 (18%) Query: 69 DPCLVSPEVTEPRK-----DPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLA 123 +PC ++ T + P + GP ++ P+ P + P A P +A Sbjct: 445 NPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMA------PVAPKEPSTQVA 498 Query: 124 SPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEG 183 + P P P E N P + FP ++D T + P + P + G Sbjct: 499 TTLRIPVSPPL---PDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFS-----PAQAG 550 Query: 184 QKSSFSFSSGIDQSPGMSPVPLREPMKAP----LCGEGDQPGGFESQEKEAAGGFP---- 235 + + P + P+ P +P + P E+ + + G P Sbjct: 551 LTTK--------KDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIG 602 Query: 236 -PAESRQGVASVQVTPEA-PAAAQQGTESSAVLEKSPL--KPMAPIP---QDPAPRASDR 288 PA S V + + G +S+ L KS L +A P DPA A Sbjct: 603 KPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTT 662 Query: 289 ERGQGEAPPQYLTDDLEFLRACH--LPRSNS---------GAAPEAEVN---AASQESCQ 334 +G Y T FL P+++ P A N A S ++ Sbjct: 663 AKGTST----YTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTC 718 Query: 335 QPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTID-------VQGHPQ------TGMR 381 P+ + E+P +PSP+L P G + +D I V P+ +G Sbjct: 719 APLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGAS 778 Query: 382 GTKPNQVVCVAAGGQPEG-GLPVSPE--------------------PSLLTPTEEAH-PA 419 T ++ P G+ VSP+ S ++P E + P Sbjct: 779 ATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPE 838 Query: 420 SSLASFPAAQIPIAVEEPGSSSRES--VSKAGMPVSADAA----KEVVDAGLVGL----- 468 +SL+ + P P S + A P+S KE +V L Sbjct: 839 NSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKE 898 Query: 469 ------ERQVSDLGSKGEHPE-----GDPGEVPAPSPQERG---EHLNTEQSHEVQPGVP 514 +Q L P+ P +PA SP +G T S + P P Sbjct: 899 GPATPAPKQAPALSMTSSSPKKARATPAPKGIPA-SPSPKGAPTPPAATPPSPKGGPATP 957 Query: 515 PP---PLPKEQSHEVQPGAPPPPLPK-APSESARGPPGPTDGAKVHEDSTSPAVAKEGSR 570 P P P + G P P PK AP+ A PP P G +P Sbjct: 958 SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPP 1017 Query: 571 SPGDSPGGK--EEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAES---R 625 SP SP + P P + +G + K P L P + + Sbjct: 1018 SPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLK 1077 Query: 626 DHPSSHSAQPPRKGGAGHTDGPH------SQTAEADASGL---PHKLGEEDP-VLPPVPD 675 P+ +A PP G T P + T + GL PHK P PP P Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPK 1137 Query: 676 GAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKA 735 G P+GA + P L + G + + PP+P +A + Sbjct: 1138 GGLATPPPKGAPTTPAATPPSPKGGLATPPPKG-------APTTPAATPPSPKGGLATPS 1190 Query: 736 QEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLG--L 793 +G T S +G L +P P A A P P G + G Sbjct: 1191 PKGAPTTPAATPPS--PKGGLATPSPKGAPTTPA------ATPPSPKGGLATPSPKGAPT 1242 Query: 794 TALILDQDQQGIPSC-PGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPP 852 T +G P+ P +G A+ P L P + P ++ P Sbjct: 1243 TPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVV-----TPPSP 1297 Query: 853 ENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGT--- 909 + G TSP +GA + P P+ P G + PKGT Sbjct: 1298 KGGPATSP------PKGAPTPPAATPPSPKGSPGTPPPKGAPTP--PAVTPPSPKGTPTL 1349 Query: 910 LSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPE------GACGDGQSSRVSP 963 + TP+S S + P+ + PA+ P+ GD S V P Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP 1409 Query: 964 ------PAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGA 1017 PA V ++ A S+ + P ++A A + +G + + P Sbjct: 1410 LSPKKAPATPVTREG--AATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDP-T 1466 Query: 1018 SEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAP 1077 A SP + +++A+ ++ + P P + P LPA+ P+SP P Sbjct: 1467 LPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM----GAPTLPAVIPSSPKEVPA---- 1518 Query: 1078 ETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAG 1137 T R+ P+ AP + T +PK A P A Sbjct: 1519 -------TPSSRRDPI-APTATLLSKKTPATLAPK-EALIPPA----------------- 1552 Query: 1138 AGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPA 1197 P ++ P P T E +T + +E AS A+ P+ Sbjct: 1553 MTVPSPKKTPAIP----------------TPKEAPATPSSKE--------ASSPPAVTPS 1588 Query: 1198 RELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVS 1257 G P PKELL+ PP V +P E AV+ Sbjct: 1589 TYKG--------------APSPKELLI--PPAVTSPSP------------KEAPTPPAVT 1620 Query: 1258 SADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSP--K 1315 P +P P G P +SLK +P G +P QAS G P K Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLK--DSPTSPASVTCKMGATVP--QASKGLPAKK 1676 Query: 1316 ARTTEGPVDSMPCLDRMPLLA----KGKQATGEEKAATAPGAGAKASGEGMAGDAAGETE 1371 T V P + P++ KG Q T + A + P ++ G G + Sbjct: 1677 GPTALKEVLVAPAPESTPIITAPTRKGPQ-TKKSSATSPPICPDPSAKNGSKGPLSTVAP 1735 Query: 1372 GSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREH---IAKIFEKPVLGALATPG 1428 + P Q T+ G D S L P+ + A FEK P Sbjct: 1736 APL----LPVQKDSSKTAKGKDASHSPKGPLAP-PESKASTPLTAAAFEK------VLPK 1784 Query: 1429 EKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQL--AGEAEISH 1486 ++ + +A ++ PL P + PP LP+ P + + L A E E+ Sbjct: 1785 PESASVSAAPSPPVSLPLAPSPVPTLPP--KQQFLPSSPGLVLESPSKPLAPADEDELLP 1842 Query: 1487 LALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAY 1546 L +P S G+ ++ L K AG+P ++P G E Sbjct: 1843 LIPPEPIS------GGVPFQSVLVNMPTPKS-AGIPVPTPSAKQPVTKNNKGSGTE---- 1891 Query: 1547 SQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDR 1593 S + S EL + A TQ+ + AA P S +++ ++ + Sbjct: 1892 SDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKK 1938 Score = 80.5 bits (197), Expect = 2e-14 Identities = 257/1153 (22%), Positives = 374/1153 (32%), Gaps = 158/1153 (13%) Query: 1249 EDSGVKAVSSADPRAP--GESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPA 1306 EDSG A +S+ +SP P+G K GS P G + Sbjct: 773 EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTK--KGSAGPDTPIGNLSSPVSP 830 Query: 1307 VQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDA 1366 V+AS + + +G DS P P K A P A S +G+ Sbjct: 831 VEASFLPENSLSFQGSKDS-PATTHSP-------TPPSPKGAPTPSAVTPLSPKGVTLPP 882 Query: 1367 AGETEGSMERMGEPSQDP-----KQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVL 1421 S+ + P + P KQ + + +SS + A T P P Sbjct: 883 KETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTP 942 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLG-PEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAG 1480 A P K G + T P P GP P PPA K G Sbjct: 943 PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPK---GG 999 Query: 1481 EAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPG 1540 A S P + P G P G A PP+ P+G AA P Sbjct: 1000 PATPSPKGAPTPPAVTPPSPKGSPAATPFP-KGASTPPAATPPS------PKGSPAATPL 1052 Query: 1541 LEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVA---PHSHGEEAVAQDRIPSG 1597 +G + A+ LPSP P + A A P G A PS Sbjct: 1053 PKGAPTTP--------AATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPAT-----PSP 1099 Query: 1598 KQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLG 1657 K A P + G H G P P +T PSP+ + T P G Sbjct: 1100 KGAPMPPAATPPSPKGGLATPPHKGAPT-TPAAT-PPSPKGGLATPPPK----------G 1147 Query: 1658 GERRPGVTAGILEMRNALGNQSTPAP---PTGEVADTPLEPGKVAGAAGEAEGDITLSTA 1714 P T + G +TP P PT A P G +A + + A Sbjct: 1148 APTTPAATPP-----SPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKG--------A 1194 Query: 1715 ETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAP-GMEGTAALHGDSPARPQ 1773 T A+ P+ G G+ PA + +P G T + G +P P Sbjct: 1195 PTTPAATPPSPKGGLATPSP--------KGAPTTPAATPPSPKGGLATPSPKG-APTTPA 1245 Query: 1774 QAKEQP--GPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLP 1831 P GP P P G ++PP AP SP+ GP+ Sbjct: 1246 ATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPA--- 1302 Query: 1832 SVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQ 1891 + P K AP T +G+ GT A P+ +PTL A++ G Sbjct: 1303 TSPPKGAP-TPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSK--GG 1359 Query: 1892 VSTDLIAQSISPAAA---HAG----LPPSAAEHIVSPSAPAGDRVEASTPSCPD--PAKD 1942 +T + +P AA H G PPS PS A P P PA Sbjct: 1360 PTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATP 1419 Query: 1943 LSR--SSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVS---------TQPPPEEPG 1991 ++R ++ + TP + TPV AP P+ P S T P P+EP Sbjct: 1420 VTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPP 1479 Query: 1992 CGSETVPVPD---GPRSDSVEGSPFRP------PSHSFSAVFDEDKPIASSGTYNLDFDN 2042 + P + + G+P P P + PIA + T Sbjct: 1480 APKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTP 1539 Query: 2043 IELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGN 2102 L + P + ++ K + P SK S ++ S + GA S Sbjct: 1540 ATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPP-AVTPSTYKGAPS--- 1595 Query: 2103 PEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPP--------VKETQ 2154 P+ + + P S A + T PPS +K T P TP +K++ Sbjct: 1596 PKELLIPPAVTSPSPKEAPTPPAVT----PPSPEKGPATPAPKGTPTSPPVTPSSLKDSP 1651 Query: 2155 QEPDEESL-----VPSGENLASETKTESAKTE---GPSPALLEETPLEPAVGPKAACPLD 2206 P + VP K +A E P+P E TP+ A K Sbjct: 1652 TSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAP---ESTPIITAPTRKGPQTKK 1708 Query: 2207 SESAEGVV---PPASGGGRVQNSPPVGRKTLPL------TTAPEAGEVTPSDSGGQEDSP 2257 S + + P A G + S LP+ T + +P +S Sbjct: 1709 SSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESK 1768 Query: 2258 AKGLSVRLEFD--YSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTP 2315 A F+ + +S+ + +PP + + PV +P ++ + +P + +P Sbjct: 1769 ASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESP 1828 Query: 2316 ASPPRSPAEPNDI 2328 S P +PA+ +++ Sbjct: 1829 -SKPLAPADEDEL 1840 Score = 58.5 bits (140), Expect = 9e-08 Identities = 154/701 (21%), Positives = 230/701 (32%), Gaps = 124/701 (17%) Query: 1827 PSMLPSVPKKDAPRVMDKVT---SDETRGAEGTESSPVADDIIQPAAPADLESPTLAASS 1883 P + PSV K P + +T S A SP I++ + A P +A Sbjct: 375 PVVAPSVDK--GPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMP 432 Query: 1884 YHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAG--DRVEASTPSCPDPAK 1941 V V T + + A A VSP +G +E ++P+ A Sbjct: 433 -----VSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAP 487 Query: 1942 DLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE--PEVSTQPPPEEPGCGSETVPV 1999 + ++ A T ++ P +PP P PE + V + P ++ +TVP Sbjct: 488 VAPKEPSTQVA-------TTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKD---LQTVPA 537 Query: 2000 PDGPRSDSVEGSPFRPPSHSFSAVFDEDK-PIASSGTYNLDFDNIELVDTFQTLEPRASD 2058 S+EG+PF P + D P+ + N L P A+ Sbjct: 538 -------SLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATL 590 Query: 2059 AKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSG----------------- 2101 AK G+ K S+ S + ++ + G S+G Sbjct: 591 AKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPL 650 Query: 2102 ---NPEAVA-LAPDAYSTGSSSASSTLKRTKK--PRPPSLKKKQTTKKP-----TETPPV 2150 +P VA ST +++AS L+ T P+ +K+ T P +E PV Sbjct: 651 ESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPV 710 Query: 2151 KETQQE-----------PDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGP 2199 + Q P+ VPS + T + K +G S + L P Sbjct: 711 APSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGIS----HTSALAPVASS 766 Query: 2200 KAACPLDSESAEGVVPPASGGGRVQNSP-PVGRKTLPLTTAP--EAGEVTPSDSGGQEDS 2256 CP + A + +SP P+G P T P + G P G S Sbjct: 767 PKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSS 826 Query: 2257 PAKGLSVRLEFDYSEDKSSWDNQQENP-------PPTKKIGKKPVAKMPLRRPKMKKTPE 2309 P + E+ S+ +++P PP+ K P A PL PK P Sbjct: 827 PVSPVEASF---LPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLS-PKGVTLPP 882 Query: 2310 KLDNTPAS-----PPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQ 2364 K TP+ P PA P P + SS+ K + P+ Sbjct: 883 KETPTPSVVNLPFPKEGPATPAPKQA--------------PALSMTSSSPKKARATPAPK 928 Query: 2365 QSYNFDPDTCDESVDPFKTSSKTPSSPSKSPAS-----FEIPASAMEANGVDGDGLNKPA 2419 P P + TP SP PA+ P +A + G P Sbjct: 929 -GIPASPSPKGAPTPP----AATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPK 983 Query: 2420 KKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPT-PAATPETP 2459 P T SPK P + P PT PA TP +P Sbjct: 984 GAPTPPAATPP-----SPKGGPATPSPKGAPTPPAVTPPSP 1019 Score = 47.0 bits (110), Expect = 3e-04 Identities = 207/956 (21%), Positives = 307/956 (32%), Gaps = 152/956 (15%) Query: 1634 PSPQREVLTVPEANSEPWT--LDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADT 1691 P PQ E +P +++ T L G P + + + NQ++P P +A T Sbjct: 17 PQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIAST 76 Query: 1692 PLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPAC 1751 PLE ++G A + L TA +L + +A ++ P P Sbjct: 77 PLEVPFPQSSSGTA---LPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTP-- 131 Query: 1752 SDKAPGMEGTAALHG--DSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQ 1809 S AP A H S A P P P + + +S+P P E L Sbjct: 132 SSSAPLALVALAPHSVQKSSAFPPNLLTSP-PSVAVAESGSVITLSAPIAPSEP-KTNLN 189 Query: 1810 HLAPEELHTDRESPRPGPSMLPSVPK---------KDAPRVMDKVTSDETR--GAEGTES 1858 + E + + +P P P ++ +VP + + + T T + + Sbjct: 190 KVPSEVVPNPKGTPSP-PCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKD 248 Query: 1859 SPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSI-----SPAAAHAGLPP- 1912 + ++ +I P P L S G V + L QS+ S A PP Sbjct: 249 TTISSVLISPQNPGSL--------SLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD 300 Query: 1913 ---SAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPP 1969 S H+ + V+ + P D + + S + T S ++ P Sbjct: 301 FPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPL 360 Query: 1970 PPPPEVIPEP----EVSTQPPPEEPGCGSETVPVPDGPR--SDSVEGSPF------RPPS 2017 P EV+P V + P S P G + S SP P+ Sbjct: 361 PSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPN 420 Query: 2018 HSFSAVFDEDKPIASSGTYNLDFDN---IELVDTFQTLEPRASDAKNQEGKVNTRRKSTD 2074 ++ P++S GT L N I T G ++ ++ Sbjct: 421 ATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSP 480 Query: 2075 SVPISKSTLSRSLSLQASD---FDGASSSGNPEAVALAPDA----YSTGSSSASSTLKRT 2127 + + + S Q + + +PE + P + + T + Sbjct: 481 AALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLE 540 Query: 2128 KKPRPPSLKKKQTTKKPTETPPVKET-QQEPDEESLVPSGENLASETKTESAKTEGP--- 2183 P P+ T K PT P V+ + P +S S E S T + K+ G Sbjct: 541 GAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLP 600 Query: 2184 --SPALLEETPL-----------EPAVGPK---------------AACPLDSESAEGVVP 2215 PA +PL + GP AA PL+S GV P Sbjct: 601 IGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAP 660 Query: 2216 PASGG-------------GRVQNSP---PVGRKTL-PLTTAPEAGEVTPSDSGGQED-SP 2257 + G G V +P PV TL L P A E P Q +P Sbjct: 661 TTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAP 720 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKI-------GKKPVAKMPLRRP-------- 2302 L + E S S PP TKK+ PVA P P Sbjct: 721 LATLVLAPEIPKSVPSPSLP-PAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASA 779 Query: 2303 --KMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESP 2360 K T L ++P SP + P K T D SS E+ Sbjct: 780 TASSKGTLTYLADSP-----SPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEAS 834 Query: 2361 KLPQQSYNF-----DPDTCDESVDPFKTSSKTPSSPSK-SPASFEIPASAMEANGV---- 2410 LP+ S +F P T P + TPS+ + SP +P V Sbjct: 835 FLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLP 894 Query: 2411 -DGDGLNKPAKKKKTPLKTDTFRVKK-----SPKRSPLSDPPSQDPT-PAATPETP 2459 +G PA K+ L + KK +PK P S P PT PAATP +P Sbjct: 895 FPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSP 950 Score = 46.2 bits (108), Expect = 5e-04 Identities = 103/419 (24%), Positives = 143/419 (34%), Gaps = 97/419 (23%) Query: 1970 PPPPEVIPEPEVSTQPPPEEP--------GCGSETVPVPDGPR------SDSVEGSPFRP 2015 P + +P+P+ T P G T+P P P S + + SPF Sbjct: 10 PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPS 69 Query: 2016 PSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDS 2075 PS S + P +SSGT L TF N G Sbjct: 70 PSTIASTPLEVPFPQSSSGT-ALPLGTAPEAPTF---------LPNLIGP---------- 109 Query: 2076 VPISKSTLSRSLSLQASDFDGASSSGNPEA-VALAPDAYSTGSS--------------SA 2120 PIS + L+ + + A G SS P A VALAP + S+ + Sbjct: 110 -PISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAE 168 Query: 2121 SSTLKRTKKPRPPSLKKKQTTKKPTE-TPPVKETQQEPDEESLVP-----------SG-E 2167 S ++ P PS K K P+E P K T P S VP SG Sbjct: 169 SGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVA 228 Query: 2168 NLASETKTESAKTEGP------------SPALLEETPLEPAVGPKAACPLDSESAEGVVP 2215 +L T T + P SP L+ V P AA L ++S V Sbjct: 229 SLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTS 288 Query: 2216 PASGGGRVQNSPP-----VGRKTLPL-----TTAPEAGEVTPSDSGGQEDSPAKGLSVRL 2265 G N+PP +G PL + G+ PS D K +SV Sbjct: 289 SQKTAG--PNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPS---ALSDPTVKTISV-- 341 Query: 2266 EFDYSEDKSSWDNQQENPPP---TKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRS 2321 D+S +S+ +Q+ PP ++ VA P+ P + K P + + SP S Sbjct: 342 --DHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGS 398 Score = 33.5 bits (75), Expect = 3.2 Identities = 70/350 (20%), Positives = 116/350 (33%), Gaps = 63/350 (18%) Query: 36 QDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLL 95 ++ P +P ++ASS +V + + + S L+ P VT P P+ A P Sbjct: 1568 KEAPATPSSKEASSPPAVTPSTY----KGAPSPKELLIPPAVTSP--SPKEAPTPPAVTP 1621 Query: 96 PSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPE-----DGPQTQSPRREPAPNAPGDI 150 PSP P + P SP + Q+ + PA P + Sbjct: 1622 PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTAL 1681 Query: 151 AAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPG----MSPVPLR 206 A STP I A G + + S + S G ++P PL Sbjct: 1682 KEVLVAPAPESTPI--ITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPL- 1738 Query: 207 EPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGV----------------ASVQVTP 250 P+ + + + G P ES+ ASV P Sbjct: 1739 ----LPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794 Query: 251 EAPAAA-------------QQGTESS-AVLEKSPLKPMAPIPQDPAPRASDRERGQGEAP 296 P + QQ SS ++ +SP KP+AP +D E G P Sbjct: 1795 SPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVP 1854 Query: 297 PQYLTDDLEFLRACHLP-----------RSNSGAAPEAEVNAASQESCQQ 335 Q + ++ ++ +P ++N G+ E++ + + E +Q Sbjct: 1855 FQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQ 1904 >gi|91982772 mucin 17 [Homo sapiens] Length = 4493 Score = 92.4 bits (228), Expect = 6e-18 Identities = 305/1577 (19%), Positives = 499/1577 (31%), Gaps = 206/1577 (13%) Query: 1071 TPTQDAPETEACDETQEGRQQPVPAP-QQKMECWATSDAESPKLLASFPSAGEQGGEAGA 1129 TP ++ E + T EG P P + + D+ +P + + + + Sbjct: 894 TPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTST 953 Query: 1130 AETGGSAGAGDP----GKQQAPEKPGEATLSCGLLQTEHCLTSGEEAST---------SA 1176 T + P G P E T H L + EAST + Sbjct: 954 PVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTP 1013 Query: 1177 LRESCQAEHPMASCQDALLPAR--ELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPD 1234 L S +A P + + +P G P + M ST L + P + + P Sbjct: 1014 LTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPV 1073 Query: 1235 TPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPL 1294 T Y S++ ++AD + S G PL S +L S A Sbjct: 1074 TTYSQASSSS------------TTADGTSMPTSTYSEGSTPLT-SVPVSTRLVVSSEAST 1120 Query: 1295 LQPGAAGGEIPAVQASSGSPKARTTEG-------PVDSMPCLDRMPLLAKGKQATGEEKA 1347 L IP ++ S T EG P + L MP+ ++ Sbjct: 1121 LSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTL 1180 Query: 1348 ATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPD 1407 +T P D+ + S E P + TS T E+ LT P Sbjct: 1181 STTP------------VDSKTQVATSTEASSPP--PTAEVTSMPTSTPGERSTPLTSMPV 1226 Query: 1408 FREHIAK-----IFEKPV--LGALATPGEKAGAGRSAVGKDLTRPLGPE--KLLDGPPGV 1458 +A + PV + T E + + +A G L E LL P V Sbjct: 1227 RHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIP-V 1285 Query: 1459 DVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERN---LPGAGVG 1515 TL+ +P A + G S+ P + T+ L V Sbjct: 1286 STTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVN 1345 Query: 1516 KEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAA 1575 + P S + + PS T + + Sbjct: 1346 TTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVST 1405 Query: 1576 AFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPS 1635 V+ + A D G E A SP +G +P P P Sbjct: 1406 TPVVSSEASTLSATPVDTSTPGTTSAE--ATSSPTTAEG------ISIPTSTPSEGKTPL 1457 Query: 1636 PQREVLTVPEANSEPWTLDTLG-GERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLE 1694 V P ANSE TL T P VT+ A+ + TPA T TP E Sbjct: 1458 KSIPVSNTPVANSEASTLSTTPVDSNSPVVTS------TAVSSSPTPAEGTSIAISTPSE 1511 Query: 1695 PGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDK 1754 G A +T T AS ++ TT +V + + + Sbjct: 1512 -GSTA---------LTSIPVSTTTVASSEINSLSTTP--AVTSTPVTTYSQASSSPTTAD 1559 Query: 1755 APGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPE 1814 M+ + G +P P + + + ++P D K Q A Sbjct: 1560 GTSMQTSTYSEGSTP-----LTSLPVSTMLVVSSEANTLSTTP------IDSKTQVTAST 1608 Query: 1815 ELHTDR---------ESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDI 1865 E + +P G +L S+P P + ++ T + +SPV Sbjct: 1609 EASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVD--SNSPVITST 1666 Query: 1866 IQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPA 1925 ++P E ++ S+Y G+ I +P A+ A S V S P Sbjct: 1667 EVSSSPTPAEGTSMPTSTY---TEGRTPLTSITVRTTPVASSAISTLSTTP--VDNSTPV 1721 Query: 1926 GDRVEASTPSCPDPAKDLSRSSDSE---EAFETPESTTPVKAPPAPPPPPPEVIPEPEVS 1982 EA + + S+ SE P STTPV + A + V+ Sbjct: 1722 TTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVT 1781 Query: 1983 TQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDN 2042 T +E +P S+ + P SH+ A + ++ T +D ++ Sbjct: 1782 TSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVA----NSEASTLSTTPVDSNS 1837 Query: 2043 IELVDTFQTLEPRASDAKNQEGKVNTRRKST-DSVPISKSTLSRSLSLQASDFDGASSSG 2101 + T + P ++ + + + S+P+S +T++ S + S +S+ Sbjct: 1838 PVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTP 1897 Query: 2102 NPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEES 2161 ++ + SS ++ R +P S+ TT +E + T D + Sbjct: 1898 VTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTL--ADTRT 1955 Query: 2162 LVPSGENLASETKTESAKTEGPSPALLE-ETPL-----------EPAVGPKAACPLDSE- 2208 V + + AS + T + T P+PA E TPL + P+D+ Sbjct: 1956 PVTT-YSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTST 2014 Query: 2209 ----SAEGVVPPASGGG-RVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSV 2263 S EG P + GG +Q S P +T PL P + + S G Sbjct: 2015 PATTSTEGSSSPTTAGGTSIQTSTP-SERTTPLAGMPVSTTLVVSSEGN----------- 2062 Query: 2264 RLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLR-RPKMKKTPEKLDNTPASPPRSP 2322 L + K+ N E G P P + P L TP + P Sbjct: 2063 TLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIP--LSTTPVASPE-- 2118 Query: 2323 AEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFK 2382 A T +D + +P +++++ SP +P + + T + P Sbjct: 2119 --------ASTLSTTPVD-----SNSPVITSTEVSSSP-IPTEGTSMQTSTYSDRRTPL- 2163 Query: 2383 TSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPL 2442 + P S + AS+ + L+ TP+ T++ + SP S Sbjct: 2164 ---------TSMPVSTTVVASSAIST------LSTTPVDTSTPV-TNSTEARSSPTTSEG 2207 Query: 2443 SDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLS 2502 + P+ P+ +TP T +S + T E T V + P ++ + Sbjct: 2208 TSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGT 2267 Query: 2503 TFVNETKFSSPTEELDYRNSYEIEYMEKIG--SSLPQDDDAPKKQALYLMFDTSQESPVK 2560 + T T S+ + ++ S+ P D + P F TS E+ Sbjct: 2268 SIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTP--------FTTSTEA--S 2317 Query: 2561 SSPVRMSESPTPCSGSS 2577 S P + P S SS Sbjct: 2318 SPPPTAEGTSMPTSTSS 2334 Score = 80.1 bits (196), Expect = 3e-14 Identities = 284/1464 (19%), Positives = 472/1464 (32%), Gaps = 169/1464 (11%) Query: 1174 TSALRESCQAEHPMASCQDALLP--ARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVA 1231 ++ L S QA + + +P G P ++M ST + LL+ P E++ Sbjct: 185 STPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEIS 244 Query: 1232 APDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSL 1291 P V +AQ + + + S ++ AP P+ PL S+ L S Sbjct: 245 TP------VTISAQASSSPTTAEGPSLSNS-APSGGSTPLTRMPL------SVMLVVSSE 291 Query: 1292 APLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAP 1351 A L A IP + ++ S T EG S+P +G A+T P Sbjct: 292 ASTLSTTPAATNIPVITSTEASSSPTTAEGT--SIPT----STYTEGSTPLTSTPASTMP 345 Query: 1352 GAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREH 1411 A ++ S + +T + EPS P T++E + LT E Sbjct: 346 VATSEMSTLSIT---PVDTSTLVTTSTEPSSLP---------TTAEATSMLTS--TLSEG 391 Query: 1412 IAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQ 1471 + PV L E + V E D ++ + P+ Sbjct: 392 STPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSE-- 449 Query: 1472 VEKKQQLAGEAEISHLALQD-PASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDER 1530 G ++ + + P + T + E + PPT + Sbjct: 450 --------GSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSM 501 Query: 1531 PEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVA 1590 P + P + + S +AS S +T PV+ + P + EA + Sbjct: 502 P----TSTPSEGSTPLTSMSVSTMPVASSEASTLSTT--PVDTST-----PVTTSSEASS 550 Query: 1591 QDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQRE-VLTVPEANSE 1649 P G ++ + V ++ P+ V T EA+S Sbjct: 551 SSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSS 610 Query: 1650 PWTLDTLG------GERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAG 1703 T + ER +T+ + ++++ T ++TP+ A ++ Sbjct: 611 STTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSS 670 Query: 1704 E-AEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDL-VLPGSCQDPACSDKAPGMEGT 1761 AEG ++ T+ TT S A L P P + T Sbjct: 671 TTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPT 730 Query: 1762 AALHGDSPARPQQAKEQPGPERPIP----AGDGKVCVSSPPEPDETHDPKLQHLAPEELH 1817 A P P P+ +S+ P TH + Sbjct: 731 TADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTT 790 Query: 1818 TDRES-----PRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGT---ESSPVADDIIQPA 1869 T+ S P G +L S+P P VTS E T +SPV + Sbjct: 791 TEGTSMPISTPSEGSPLLTSIPVSITP-----VTSPEASTLSTTPVDSNSPVTTSTEVSS 845 Query: 1870 APADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRV 1929 +P E ++ S+Y + T L + +S + + V S P + Sbjct: 846 SPTPAEGTSMPTSTY-----SEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNST 900 Query: 1930 EASTPSCPDPAKDLSRSSDSEEAF---ETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPP 1986 EA + + S+ E + P+STTPV + A V V+T Sbjct: 901 EARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTE 960 Query: 1987 PEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELV 2046 +E +P S+ P SH+ +A+S L ++ Sbjct: 961 ATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTL---------VANSEASTLSTTPVDSN 1011 Query: 2047 DTFQTLEPRASDAKNQEG-KVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEA 2105 T +S EG + T S S P+++ +S ++ + + ++ S P Sbjct: 1012 TPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTM---VASSETSTLSTTPAD 1068 Query: 2106 VALAPDAYSTGSSSASSTLKRTKKPRPP-SLKKKQTTKKPTETPPVKETQQEPDEESLVP 2164 + YS SSS S+T T P S T P T V E S P Sbjct: 1069 TSTPVTTYSQASSS-STTADGTSMPTSTYSEGSTPLTSVPVSTRLV--VSSEASTLSTTP 1125 Query: 2165 SGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQ 2224 ++ T TE++ SP E T + + + PL S + +S + Sbjct: 1126 VDTSIPVTTSTEASS----SPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTL- 1180 Query: 2225 NSPPVGRKTLPLTTA-----PEAGEVT--PSDSGGQEDSPAKGLSVRLEFDYSEDKSSWD 2277 ++ PV KT T+ P EVT P+ + G+ +P + VR S + S+ Sbjct: 1181 STTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLS 1240 Query: 2278 NQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTF 2337 T + T E ++ IP++ T Sbjct: 1241 --------TSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVT- 1291 Query: 2338 DIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPAS 2397 P + +T + P + + P + + P T S+ + + P + Sbjct: 1292 ------SPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVN 1345 Query: 2398 FEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPE 2457 + AS+ + L+ TP+ T T SP S + P+ +P+ TP Sbjct: 1346 TTLVASSAISI------LSTTPVDNSTPVTTST-EACSSPTTSEGTSMPNSNPSEGTTPL 1398 Query: 2458 TP-PVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLST--FVNETKFSSPT 2514 T PV + V +++ L+ T P D ST + SSPT Sbjct: 1399 TSIPVSTTPVVSSEASTLSAT--------------------PVDTSTPGTTSAEATSSPT 1438 Query: 2515 --EELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYL-MFDTSQESPVKSSPVRMSESPT 2571 E + S E + S + +A L SPV +S +S SPT Sbjct: 1439 TAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTS-TAVSSSPT 1497 Query: 2572 PCSGSSFEETEALVNTAAKNQHPV 2595 P G+S + + A PV Sbjct: 1498 PAEGTSIAISTPSEGSTALTSIPV 1521 Score = 79.0 bits (193), Expect = 7e-14 Identities = 203/1043 (19%), Positives = 347/1043 (33%), Gaps = 143/1043 (13%) Query: 1608 SPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAG 1667 SP DG + +P PR P V T A+SE TL T + R VT Sbjct: 1907 SPTTADG------SSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTY 1960 Query: 1668 ILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEA 1727 +Q++ +P T + P +EG ST T S L + Sbjct: 1961 ---------SQASSSPTTADGTSMP--------TPAYSEG----STPLTSMPLSTTLVVS 1999 Query: 1728 GTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPA-RPQQAKEQPGPERPIP 1786 T S D P + S +P G ++ +P+ R P + Sbjct: 2000 SEASTLSTTPVDTSTPATTSTEGSS--SPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVV 2057 Query: 1787 AGDGKVCVSSPPEPDE--THDPKLQHLAPEELHTDRES-PRPGPSMLPSVPKKDAPRVMD 1843 + +G ++P + T+ + A E + S P G +L S+P P Sbjct: 2058 SSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASP 2117 Query: 1844 KVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISP 1903 + ++ T + +SPV ++P E ++ S+Y T L + +S Sbjct: 2118 EASTLSTTPVDS--NSPVITSTEVSSSPIPTEGTSMQTSTY-----SDRRTPLTSMPVST 2170 Query: 1904 AAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAF---ETPESTT 1960 + + + V S P + EA + + S+ SE + P ST Sbjct: 2171 TVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTM 2230 Query: 1961 PVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSF 2020 PV A V V+T +E +P S+ P SH+ Sbjct: 2231 PVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTL 2290 Query: 2021 SAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEG-KVNTRRKSTDSVPIS 2079 +A+S L ++ F T +S EG + T S + P++ Sbjct: 2291 ---------VANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLT 2341 Query: 2080 KSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQ 2139 + +S ++ + F+ ++ S P + YS SS ++ + S Sbjct: 2342 RMPVSTTM---VASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTP 2398 Query: 2140 TTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGP 2199 T P T PV ++ + V + + + T+ S+ T ++ P E P Sbjct: 2399 LTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTT-P 2457 Query: 2200 KAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAK 2259 A+ P+ + P S ++ PV T P+TT+ EA SP Sbjct: 2458 LASMPVST------TPVVSSEAGTLSTTPVDTST-PMTTSTEASS-----------SPTT 2499 Query: 2260 GLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPK---MKKTPEK-----L 2311 + + + + S+ + PV+ P+ P+ + TP + Sbjct: 2500 AEDIVVPISTASEGSTL------------LTSIPVSTTPVASPEASTLSTTPVDSNSPVV 2547 Query: 2312 DNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDP 2371 +T S + AE +P + TY+ P S + P ++ Sbjct: 2548 TSTEISSSATSAEGTSMPTS--TYS--------EGSTPLRSMP-VSTKPLASSEASTLST 2596 Query: 2372 DTCDESVDPFKTSSKTPSSPSK--------------SPASFEIPASAMEANGVDGDGLNK 2417 D S+ P TS++T SSP+ S + I S M + L+ Sbjct: 2597 TPVDTSI-PVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLST 2655 Query: 2418 PAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVT 2477 +T + T T SP + S P+ P +TP T ++S + A E T Sbjct: 2656 TPVDTRTLVTTST-GTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLST 2714 Query: 2478 NQKWTCMTVDLEADKQDYP-----------QPSDLSTFVNETKFSS---PTEELDYRNSY 2523 T V A+ P PSD ST + S+ + E ++ Sbjct: 2715 TPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTT 2774 Query: 2524 EIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQES-------PVKSSPVRMSESPTPCSGS 2576 ++ + +S + + T E+ PV +PV SE+ T + Sbjct: 2775 AVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTP 2834 Query: 2577 SFEETEALVNTAAKNQHPVPRGL 2599 T +T A + G+ Sbjct: 2835 VDTSTPVTTSTKASSSPTTAEGI 2857 Score = 79.0 bits (193), Expect = 7e-14 Identities = 215/1042 (20%), Positives = 349/1042 (33%), Gaps = 116/1042 (11%) Query: 1603 TSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRP 1662 T A SP +G T +P P P V T P +SE TL T + Sbjct: 2432 TEASSSPTTAEG------TSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTST 2485 Query: 1663 GVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASG 1722 +T +++ +P T E P+ A E +T T AS Sbjct: 2486 PMTTS---------TEASSSPTTAEDIVVPIS------TASEGSTLLTSIPVSTTPVAS- 2529 Query: 1723 DLPEAGTTRTFSVVAGDLVLPGS-CQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGP 1781 PEA T T V + V+ + A S + M + G +P R P Sbjct: 2530 --PEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLR-----SMPVS 2582 Query: 1782 ERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRV 1841 +P+ + + ++P + + + D P PS + + Sbjct: 2583 TKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVST 2642 Query: 1842 MDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLA-ASSYHGDVVGQ--------- 1891 M +S+ A ++PV + + SPT A SS G+ Sbjct: 2643 MPVASSE----ASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNIL 2698 Query: 1892 VSTDLIAQS----ISPAAAHAGLP-PSAAEHIVSPSAPAGDRVEASTPSCPD-PAKDLSR 1945 VST L+A S +S P ++AE SP+ G + STPS P + Sbjct: 2699 VSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILV 2758 Query: 1946 SSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEP---EVSTQPP--PEEPGCGSETVPVP 2000 S+ + E +T P E P EV++ P P E ++PV Sbjct: 2759 STLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVN 2818 Query: 2001 DGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYN---LDFDNIELVDTFQTLEPRAS 2057 P + S G+ P + + V K +S T + T T P ++ Sbjct: 2819 HTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVST 2878 Query: 2058 D--AKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYST 2115 A ++ ++T T S+P++ ST S A S+ + + L ST Sbjct: 2879 TPVASSEASTLSTTPVDT-SIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVST 2937 Query: 2116 ------GSSSASSTLKRTKKPRPPSLKKKQT------TKKPTETPPVKETQQEPDEESLV 2163 +S+ S+T T+ P S + + T P TP + T S + Sbjct: 2938 VPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTM 2997 Query: 2164 PSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRV 2223 P + AS A T P E + P P+ + S EG P S V Sbjct: 2998 PVASSEASTLSRTPADTSTPVTTSTEASS-SPTTAEGTGIPISTPS-EGSTPLTSIP--V 3053 Query: 2224 QNSPPVGRKTLPLTTAP--EAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQE 2281 +P + L+T P V S +PA+G S+ + YSE + Sbjct: 3054 STTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPIS-TYSEGSTPLTGVPV 3112 Query: 2282 NPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS------PPRSPAEPNDIPIAKGTY 2335 + P ++ P+ T + ++P + P +P+E + Sbjct: 3113 STTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVS 3172 Query: 2336 TFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSP 2395 T + +D S + + S + + T + + P T S+ + + P Sbjct: 3173 TMLVVSSEDSTL----SATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVP 3228 Query: 2396 ASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAAT 2455 S P ++ EA+ L+ TPL T T SP + + P+ P+ +T Sbjct: 3229 VS-NTPVASSEASI-----LSTTPVDSNTPLTTST-EASSSPPTAEGTSMPTSTPSEGST 3281 Query: 2456 PETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNET--KFSSP 2513 P T +S A+ E T T V + P +D ++ T + S+P Sbjct: 3282 PLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTP 3341 Query: 2514 TEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPC 2573 + + + + S+ P D P TS E+ S SPT Sbjct: 3342 LTNMSFSTTPVVSSEASTLSTTPVDTSTP--------VTTSTEA---------SLSPTTA 3384 Query: 2574 SGSSFEETEALVNTAAKNQHPV 2595 G+S + T PV Sbjct: 3385 EGTSIPTSSPSEGTTPLASMPV 3406 Score = 75.1 bits (183), Expect = 1e-12 Identities = 193/901 (21%), Positives = 298/901 (33%), Gaps = 140/901 (15%) Query: 1608 SPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAG 1667 S G P T +P P P V TVP A SE TL T + R VT Sbjct: 2903 STEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTS 2962 Query: 1668 ILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEA 1727 +++ +P T E P+ GE +T + T AS + Sbjct: 2963 A---------EASSSPTTAEGTSMPIS------TPGERRTPLTSMSVSTMPVASSE---- 3003 Query: 1728 GTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPA 1787 T S D P + A S EGT G + P + P IP Sbjct: 3004 --ASTLSRTPADTSTPVTTSTEASSSPTTA-EGT----GIPISTPSEGST---PLTSIPV 3053 Query: 1788 GDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTS 1847 V + PE + +P T+ S P P+ S+P +T Sbjct: 3054 STTPVAI---PEASTLSTTPVDSNSPVVTSTEVSSS-PTPAEGTSMPISTYSEGSTPLTG 3109 Query: 1848 DETRGAEGTESSPVADDIIQPAA--PADLESPTLAASSYHGDVVGQVSTDLIAQSISPAA 1905 ++PV I + P D +P ++ H T + + S + Sbjct: 3110 VPV------STTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGS 3163 Query: 1906 AHAGLPPSAAEHIVSPSAPAGDRVEASTP---SCPDPAKDLSRSSDSEEAFETPEST--- 1959 P + +VS D ++TP S P + SS + E P ST Sbjct: 3164 TPLTYMPVSTMLVVSSE----DSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSE 3219 Query: 1960 --TPVKAPPAPPPP----PPEVIPEPEVSTQPPPEEPGCGSETVPVPDG---PRSDSVEG 2010 TP+ + P P ++ V + P S + P +G P S EG Sbjct: 3220 GMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEG 3279 Query: 2011 SPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEG-KVNTR 2069 S +++ +ASS T L + T +S +G + T Sbjct: 3280 ST------PLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTS 3333 Query: 2070 RKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKK 2129 S S P++ + S + + + AS+ P ST +S + +T + T Sbjct: 3334 TYSEGSTPLTNMSFSTTPVVSSE----ASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSI 3389 Query: 2130 PRP-PSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALL 2188 P PS P T PV E + S P N T TE++ SP + Sbjct: 3390 PTSSPSEGTTPLASMPVSTTPV--VSSEVNTLSTTPVDSNTLVTTSTEASS----SPTIA 3443 Query: 2189 EETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTA------PEA 2242 E T L + + + PL S P AS ++ PV T P+TT+ P Sbjct: 3444 EGTSLPTSTTSEGSTPL-SIMPLSTTPVASSEASTLSTTPVDTST-PVTTSSPTNSSPTT 3501 Query: 2243 GEVT--PSDSGGQEDSPAKGLSVRLEFDYSEDKSSWD-------------NQQENPPPTK 2287 EVT P+ + G+ +P + V S + S+ +Q + P T Sbjct: 3502 AEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATL 3561 Query: 2288 KIGKKPVAKMPLRRPK--------MKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDI 2339 + V M + P M + + ++ AS P +P+ P+ T + Sbjct: 3562 Q-----VTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNST 3616 Query: 2340 DKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDES-------VD---PFKTSSKTPS 2389 + P S+ S++ S L + T E+ VD P TS++ S Sbjct: 3617 PTPPEVITLPMSTPSEV--STPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSS 3674 Query: 2390 SP--------------SKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKK 2435 SP S +P S +G L+ P+ TP+ T T + Sbjct: 3675 SPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISS 3734 Query: 2436 S 2436 S Sbjct: 3735 S 3735 Score = 67.0 bits (162), Expect = 3e-10 Identities = 220/1045 (21%), Positives = 342/1045 (32%), Gaps = 159/1045 (15%) Query: 1603 TSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRP 1662 T A SP +G T +P P P V ANSE TL T + Sbjct: 959 TEATSSPTTAEG------TSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNT 1012 Query: 1663 GVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASG 1722 +T +++ PPT E P + +EG ST T+ S Sbjct: 1013 PLTTS---------TEASSPPPTAEGTSMP--------TSTPSEG----STPLTRMPVST 1051 Query: 1723 DLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPE 1782 + + T T S D P + A S +GT+ P Sbjct: 1052 TMVASSETSTLSTTPADTSTPVTTYSQASSSSTTA-DGTSMPTSTYSEGSTPLTSVPVST 1110 Query: 1783 RPIPAGDGKVCVSSPPEPD----ETHDPKLQHLAPEELHTDRESPRPGPSMLPSVP---- 1834 R + + + ++P + + + E P G + L S+P Sbjct: 1111 RLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTT 1170 Query: 1835 ---KKDAPRVMDKVTSDETRGAEGTESS---PVADDIIQPAA-PADLESPTLAASSYHGD 1887 +A + +T+ A TE+S P A+ P + P + +P + H Sbjct: 1171 LVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTP 1230 Query: 1888 VVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSS 1947 V ++ L S SP + SA E SP+ G + ST S + + L+ Sbjct: 1231 VASSEASTL---STSPVDTSTPVTTSA-ETSSSPTTAEGTSLPTSTTS--EGSTLLTSIP 1284 Query: 1948 DSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDS 2007 S +PE++T + P P V+ EVS+ P P E G+ P S Sbjct: 1285 VSTTLVTSPEASTLLTTPVDTKGP---VVTSNEVSSSPTPAE---GTSM------PTSTY 1332 Query: 2008 VEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVN 2067 EG R P S +ASS L ++ T S EG Sbjct: 1333 SEG---RTPLTSIPV---NTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSM 1386 Query: 2068 TRRKSTD------SVPISKSTL--SRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSS 2119 ++ S+P+S + + S + +L A+ D S+ G A A + + G S Sbjct: 1387 PNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVD-TSTPGTTSAEATSSPTTAEGISI 1445 Query: 2120 ASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAK 2179 +ST PS K P PV ++ + V S + + T S+ Sbjct: 1446 PTST---------PSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSP 1496 Query: 2180 TEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTA 2239 T PA G A SE + + V +S T P T+ Sbjct: 1497 T--------------PAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTS 1542 Query: 2240 PEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDN----------QQENPPPTKKI 2289 VT + A G S++ YSE + + + N T I Sbjct: 1543 TP---VTTYSQASSSPTTADGTSMQTS-TYSEGSTPLTSLPVSTMLVVSSEANTLSTTPI 1598 Query: 2290 GKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNP 2349 K T E T ++P IP++ P + Sbjct: 1599 DSKTQVTASTEASS-STTAEGSSMTISTPSEGSPLLTSIPVSTTPVA-------SPEAST 1650 Query: 2350 FSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKT--SSKTPSSPSKSPASFEIPASAMEA 2407 S+T SP + + P + + P T +TP + S + + + +SA+ Sbjct: 1651 LSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLT-SITVRTTPVASSAIST 1709 Query: 2408 NGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETP-PVISAVV 2466 L+ TP+ T T + SP S + P+ P+ TP T PV + V Sbjct: 1710 -------LSTTPVDNSTPVTTST-EARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPV 1761 Query: 2467 HATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETK--FSSPT--EELDYRNS 2522 +++ L+ T P D ST V + SSPT E S Sbjct: 1762 LSSEASTLSAT--------------------PIDTSTPVTTSTEATSSPTTAEGTSIPTS 1801 Query: 2523 YEIEYMEKIGSSLPQDDDAPKKQALYLMFD-TSQESPVKSSPVRMSESPTPCSGSSFEET 2581 E M + S+ +A L SPV +S +S SPTP G+S + Sbjct: 1802 TLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTA-VSSSPTPAEGTSIATS 1860 Query: 2582 EALVNTAAKNQHPVPRGLAPNQESH 2606 + A PV + E++ Sbjct: 1861 TPSEGSTALTSIPVSTTTVASSETN 1885 Score = 62.0 bits (149), Expect = 8e-09 Identities = 153/724 (21%), Positives = 249/724 (34%), Gaps = 92/724 (12%) Query: 1846 TSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLI---AQSIS 1902 T A GT S+ V + + + + E ++ SS D G ST + +++ S Sbjct: 61 TGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIE-SSVTSDTPGVSSTRMTPTESRTTS 119 Query: 1903 PAAAHAG-LPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTP 1961 + + + L PS+ E SP+ P G V STPS S S AF ST P Sbjct: 120 ESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPS--------EESISSTMAF---VSTAP 168 Query: 1962 VKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDG-PRSDSVEGSPFRPPSHSF 2020 + + A +V ++ST S T P P+S + EGS P S Sbjct: 169 LPSFEAYTSLTYKV----DMSTPLTTSTQASSSPTTPESTTIPKSTNSEGS---TPLTSM 221 Query: 2021 SAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEG-KVNTRRKSTDSVPIS 2079 A +ASS L +E+ +S EG ++ S S P++ Sbjct: 222 PA---STMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLT 278 Query: 2080 KSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLK-KK 2138 + LS L + + AS+ A P ST +SS+ +T + T P + Sbjct: 279 RMPLSVMLVVSSE----ASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGST 334 Query: 2139 QTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVG 2198 T P T PV ++ + V + + + T+ S T + ++L T L Sbjct: 335 PLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTST-LSEGST 393 Query: 2199 PKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGE--VTPSDSGGQEDS 2256 P P+ + + AS ++ PV KT +TTA EA T D+ + Sbjct: 394 PLTNMPVST------ILVASSEASTTSTIPVDSKTF-VTTASEASSSPTTAEDTSIATST 446 Query: 2257 PAKGLSVRLEFDY-------------------SEDKSSWDNQQENPPPTKKIGKKPVA-- 2295 P++G + S+ + + + + PPT ++ P + Sbjct: 447 PSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTP 506 Query: 2296 ---KMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 2352 PL + P + ++ AS + P+ + + P S+ Sbjct: 507 SEGSTPLTSMSVSTMP--VASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTST 564 Query: 2353 TSK-------MQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAM 2405 S+ M S +L S T + F T+S SS S + +P S Sbjct: 565 PSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTY 624 Query: 2406 EANGV---------------DGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDP 2450 G + L+ TP+ T T S S P S Sbjct: 625 SERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTS-TY 683 Query: 2451 TPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKF 2510 T +TP T ++ + A+ E T T V + P +D ++ T Sbjct: 684 TEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPS 743 Query: 2511 SSPT 2514 T Sbjct: 744 EGST 747 Score = 51.2 bits (121), Expect = 1e-05 Identities = 183/954 (19%), Positives = 290/954 (30%), Gaps = 134/954 (14%) Query: 1587 EAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEA 1646 EA R P+ T S P TG+P P P V T P A Sbjct: 3003 EASTLSRTPADTS---TPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVA 3059 Query: 1647 NSEPWTLDTLG-GERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEA 1705 E TL T P VT+ + + TPA T T E + Sbjct: 3060 IPEASTLSTTPVDSNSPVVTS------TEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVS 3113 Query: 1706 EGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALH 1765 +T S T + D TT T + + M + Sbjct: 3114 TTPVTSSAISTLSTTPVDTSTPVTTST------------EAHSSPTTSEGTSMPTSTPSE 3161 Query: 1766 GDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPE---PDETHDPKLQHLAPEELHTDRES 1822 G +P P + + + ++P + P T E + Sbjct: 3162 GSTP-----LTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTST 3216 Query: 1823 PRPGPSMLPSVPKKDAPRVMDKVT----------SDETRGAEGTESSPVADDIIQPAAPA 1872 P G + L SVP + P + + + T E + S P A+ P + Sbjct: 3217 PSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTP 3276 Query: 1873 DLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEAS 1932 S L + V T + S +PA P S S P D Sbjct: 3277 SEGSTPLTSMPVSTTTVASSETSTL--STTPADTST---PVTTYSQASSSPPIADGTSMP 3331 Query: 1933 TPSCPDPAKDLSRSSDSEEAFETPE----STTPV-KAPPAPPPPPPEVIPEPEVSTQPPP 1987 T + + + L+ S S + E STTPV + P + P T P Sbjct: 3332 TSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPT 3391 Query: 1988 EEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 2047 P G T P+ P S + P+ SS L ++ Sbjct: 3392 SSPSEG--TTPLASMPVSTT---------------------PVVSSEVNTLSTTPVDSNT 3428 Query: 2048 TFQTLEPRASDAKNQEG-KVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAV 2106 T +S EG + T S S P+S LS + + AS+ Sbjct: 3429 LVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSE----ASTLSTTPVD 3484 Query: 2107 ALAPDAYSTGSSSASSTLKRTKKPRPPSLK-KKQTTKKPTETPPVKETQQEPDEESLVPS 2165 P S+ ++S+ +T + T P + + T P T PV ++ + V S Sbjct: 3485 TSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDS 3544 Query: 2166 GENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDS--------ESAEGVVPPA 2217 + S ++ S SPA L+ T + + + + L + S+E P Sbjct: 3545 NTFVTSSSQASS------SPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPST 3598 Query: 2218 SGGGR--------VQNSPPVGRK--TLPLTTAPEAG-----------EVTPSDSGGQEDS 2256 R NS P + TLP++T E VT S++G Sbjct: 3599 PSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTL 3658 Query: 2257 PAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPA 2316 P + + P T G P+ MP+ ++ + +TP+ Sbjct: 3659 PVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPS 3718 Query: 2317 SPPRSPAEPNDIPIAKGTYTFDIDKWD---DPNFNPFSSTSKMQESP--KLPQQSYNFDP 2371 +P + I+ T D + +T + +P + P+ S P Sbjct: 3719 VVTSTPVTTSTEAISSSA-TLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIP 3777 Query: 2372 DTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTF 2431 T+S+ SSP+ + +P S T + Sbjct: 3778 SVYTSM--SMTTASEGSSSPTTLEGTTTMPMSTTSERST-----------LLTTVLISPI 3824 Query: 2432 RVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMT 2485 V + S LS PP TP T S T ++++T+++ T +T Sbjct: 3825 SVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVT-TIRISITSERSTPLT 3877 Score = 45.4 bits (106), Expect = 8e-04 Identities = 153/808 (18%), Positives = 251/808 (31%), Gaps = 137/808 (16%) Query: 666 EDPVLPPVPDGAGEP--TVPEGAIWEGSGLQPKCP----DTLQSREGLGRMESFLTLESE 719 ED P P+G P T E +I P + S M + LT ++ Sbjct: 134 EDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQ 193 Query: 720 KSDFPPTPVAEVAPKAQEGESTLEI-------RKMGSCDGEGLLTSPDQPRGPACDASRQ 772 S P TP + PK+ E + + K+ S + LLT+P + P +++ Sbjct: 194 ASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQA 253 Query: 773 EFHAGVPHPPQGENLAADLGLT---------ALILDQDQQGIPSCPGEGWIRGAASEWPL 823 P N A G T L++ + + + P AA+ P+ Sbjct: 254 SSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTP-------AATNIPV 306 Query: 824 LSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQE 883 ++S + TSI G S P A S + + P + Sbjct: 307 ITSTEASSSPTTAEGTSI------PTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVD 360 Query: 884 DNNLPTHGGQEQAL----------------GSELQSQLPKGTL----SDTPTSSPTDMVW 923 + L T + +L GS + +P T+ S+ T+S + Sbjct: 361 TSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDS 420 Query: 924 ESSLTEESEL-SAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKE 982 ++ +T SE S+PT + ++ P +G + S P + S A N S Sbjct: 421 KTFVTTASEASSSPTTAEDTSIATSTP----SEGSTPLTSMPVSTTPVASSEASNLSTT- 475 Query: 983 TCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGE 1042 P S+ + + E S A S ++G +PL +S M Sbjct: 476 -------PVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTM------- 521 Query: 1043 APPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMEC 1102 P + L P + TP + E + T EG P P + Sbjct: 522 --PVASSEASTLSTTPVDTS--------TPVTTSSEASSSSTTPEGTSIPTSTPSEGSTP 571 Query: 1103 WATSDAESPKLLASFPSA-----GEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSC 1157 + +++S S + + S+ G E + Sbjct: 572 LTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTI 631 Query: 1158 GLLQTEHCLTSGEEAST---------SALRESCQAEHPMASCQDALLPAREL--GGIPRS 1206 + L + EAST + + S +A + + +P G P + Sbjct: 632 TSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLT 691 Query: 1207 TMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRA-PG 1265 +M +T L + P + + P T A S A ++ P + P Sbjct: 692 SMPVNTTLVASSEASTLSTTPVDTSTPVT--------TSTEASSSPTTADGASMPTSTPS 743 Query: 1266 ESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEG---- 1321 E P+ P+ S L S A L ++ S TTEG Sbjct: 744 EGSTPLTSMPV------SKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMP 797 Query: 1322 ---PVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMG 1378 P + P L +P+ + +T P D+ S E Sbjct: 798 ISTPSEGSPLLTSIPVSITPVTSPEASTLSTTP------------VDSNSPVTTSTEVSS 845 Query: 1379 EPSQDPKQGTSGGVDTSSEQIATLTGFP 1406 P+ P +GTS T SE LT P Sbjct: 846 SPT--PAEGTSMPTSTYSEGRTPLTSMP 871 Score = 41.6 bits (96), Expect = 0.012 Identities = 280/1440 (19%), Positives = 442/1440 (30%), Gaps = 201/1440 (13%) Query: 13 TLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLD--- 69 TLS S P S + G+ S GS L ++ + AS + Sbjct: 1827 TLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNT 1886 Query: 70 ----PCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAE---CPPEGCL 122 P + S VT + +GS +P+ P + R P +S+P + E Sbjct: 1887 LSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRP-PLTSIPVSTTTVASSEINT 1945 Query: 123 ASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQE-------IAAVPSAGR 175 S A P T + +P + PA + STP + + ++ Sbjct: 1946 LSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTL 2005 Query: 176 ERQPKEEGQKSSFSFS-SGIDQSPGMSPVPLREPMK--APLCGEGDQPGGFESQEKEAAG 232 P + ++ S S + G + + P + PL G S E Sbjct: 2006 STTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLS 2065 Query: 233 GFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ 292 P Q S + + A A T SA E SPL + IP P AS Sbjct: 2066 TTPVDSKTQVTNSTEASSSATAEGSSMT-ISAPSEGSPL--LTSIPLSTTPVASPEASTL 2122 Query: 293 GEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAAS--QESCQQPVGAYLPHAELPWGL 350 P SNS EV+++ E Y + Sbjct: 2123 STTPVD----------------SNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSM 2166 Query: 351 PSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEG-GLPVSPEPSL 409 P V + + +D P T N ++ EG +P S Sbjct: 2167 PVSTTVVASSAISTLSTTPVDTST-PVT-------NSTEARSSPTTSEGTSMPTS----- 2213 Query: 410 LTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLE 469 TP+E + P +S+ P + +P+ E + S V + PV+ G Sbjct: 2214 -TPSEGSTPFTSM---PVSTMPVVTSEASTLSATPVDTS-TPVTTSTEATSSPTTAEGTS 2268 Query: 470 RQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPG 529 S L S+G P +P ++T + V P + + Sbjct: 2269 IPTSTL-SEGTTPLTS---IPVSHTLVANSEVSTLSTTPVDSNTP-------FTTSTEAS 2317 Query: 530 APPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEG--SRSPGDSPGGK---EEAPE 584 +PPP ++ G T ++ +T A + S +P D+ +A Sbjct: 2318 SPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGS 2377 Query: 585 PPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHT 644 P D ++ + +S P + P +E+ S+HS P T Sbjct: 2378 SPTTADDTSMP---TSTYSEGSTPLTSVPVSTMPVVSSEA----STHSTTPV------DT 2424 Query: 645 DGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSR 704 P + + EA +S P +G PT P G P + + Sbjct: 2425 STPVTTSTEASSS-------------PTTAEGTSIPTSPPS-----EGTTPLASMPVSTT 2466 Query: 705 EGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRG 764 + L+ + P T E + E + S +G LLTS Sbjct: 2467 PVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTAS-EGSTLLTSIPVSTT 2525 Query: 765 PACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEW--P 822 P P D + + S G SE P Sbjct: 2526 PVAS----------PEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTP 2575 Query: 823 LLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQ 882 L S +P + +++ + + P ETS S KD S I P E Sbjct: 2576 LRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDT---SMPISTPSEVS 2632 Query: 883 EDNNLPTHGGQEQALGSELQSQLP-----KGTLSDTPTSSPTDMVWESSLTEESELSAPT 937 +L S L S +P TLS TP + T + T S+PT Sbjct: 2633 T------------SLTSILVSTMPVASSEASTLSTTPVDTRTLVT-----TSTGTSSSPT 2675 Query: 938 RQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQAL 997 A G P G+ S P ++L +L N T + Sbjct: 2676 T----AEGSSMPTSTPGER-----STPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTS 2726 Query: 998 ADALEEGSQHEEACQRHPGASEAADGCSPLWGL--SKREMASGNTGEAPPCQPD-SVALL 1054 A+A + E R S +DG +PL + S +AS D S+ + Sbjct: 2727 AEASSSPTTAEGTSMR---ISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVT 2783 Query: 1055 DAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLL 1114 + + A PT ET + PV + + D +P Sbjct: 2784 TSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTT 2843 Query: 1115 ASFPSAGEQGGEA-----GAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSG 1169 ++ S+ E A G + P +TLS + T +T+ Sbjct: 2844 STKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTS 2903 Query: 1170 EEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPE 1229 E S+S P+++ + P L I ST+ + +A L + P + Sbjct: 2904 TEGSSSPTTAE-GTSMPISTPSEVSTP---LTSILVSTVPVAGSEA-----STLSTTPVD 2954 Query: 1230 VAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAG 1289 P T S+ AE + + + + R P S V P+A A++L Sbjct: 2955 TRTPVTTSAEASSSPTT-AEGTSMPISTPGERRTPLTS-MSVSTMPVASSEASTLSRTPA 3012 Query: 1290 SLAPLLQPGAAGGEIPAVQASSGSPKARTTEG--PVDSMPCLDRMPLLAKGKQATGEEKA 1347 + + P +G P + +EG P+ S+P Sbjct: 3013 DTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIP-------------------V 3053 Query: 1348 ATAPGAGAKASGEGMAG-DAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFP 1406 +T P A +AS D+ S E P+ P +GTS + T SE LTG P Sbjct: 3054 STTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPT--PAEGTSMPISTYSEGSTPLTGVP 3111 Score = 41.2 bits (95), Expect = 0.015 Identities = 275/1378 (19%), Positives = 436/1378 (31%), Gaps = 205/1378 (14%) Query: 14 LSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLV 73 + TP + +S + P S ++ + S+ + AS +++L V Sbjct: 2481 VDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPV 2540 Query: 74 ---SPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASP-AAAP 129 SP VT A EG+ +P+ S E P SMP + P AS + P Sbjct: 2541 DSNSPVVTSTEIS-SSATSAEGTSMPTSTYS-EGSTPLRSMPVSTKPLASSEASTLSTTP 2598 Query: 130 EDG--PQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSS 187 D P T S +P D + STP + ++ S P + S+ Sbjct: 2599 VDTSIPVTTSTETSSSPTTAKDTSMPI------STPSEVSTSLTSILVSTMPVASSEAST 2652 Query: 188 FSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQ 247 S +PV R + G S A G P S G S Sbjct: 2653 LS----------TTPVDTRTLVTTST--------GTSSSPTTAEGSSMPT-STPGERSTP 2693 Query: 248 VTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEA----PPQYLTDD 303 +T + ++ L +P+ P+ A +S +G + P + Sbjct: 2694 LTNILVSTTLLANSEASTLSTTPVDTSTPVTTS-AEASSSPTTAEGTSMRISTPSDGSTP 2752 Query: 304 LEFLRACHLPRSNSGAAPEAEVNA-------ASQESCQQPVGAYLPHAELPWGLPSPALV 356 L + LP ++S A+ + S E+ P A + +P PS Sbjct: 2753 LTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEV--TSMPTSTPSETST 2810 Query: 357 P--------------EAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP 402 P EAG +DT + + V EG Sbjct: 2811 PLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTL 2870 Query: 403 VSPEPSLLTPTEEAHPASSLASFPA-AQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVV 461 ++ P TP + AS+L++ P IP+ GSSS + MP+S + EV Sbjct: 2871 LTSIPVSTTPVASSE-ASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPS--EVS 2927 Query: 462 DAGLVGLERQVSDLGSKGEHPEGDPGE--VPAPSPQERGEHLNTEQSHEVQPGVPPPPLP 519 L V GS+ P + P + E T + + P Sbjct: 2928 TPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRT 2987 Query: 520 KEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGK 579 S V +P A SE++ P D ST + E S SP + G Sbjct: 2988 PLTSMSVS------TMPVASSEASTLSRTPAD------TSTPVTTSTEASSSPTTAEGTG 3035 Query: 580 EEAPEPPDGGDP--------GNLQGEDSQAFSS----KRDPEVGKDELSKPSSDAESRDH 627 P +G P + ++ S+ P V E+S + AE Sbjct: 3036 IPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSM 3095 Query: 628 P-SSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGA 686 P S++S G + P + +A + S P + PV + PT Sbjct: 3096 PISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTP--VDTSTPVTTST-EAHSSPTTS--- 3149 Query: 687 IWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRK 746 EG+ + P + + + L + SE S TPV P E+T Sbjct: 3150 --EGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEAT----S 3203 Query: 747 MGSCDGEGLLTS-PDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTAL-------IL 798 + +G + TS P + P V + P + A+ L T + Sbjct: 3204 STTAEGTSIPTSTPSEGMTPLTSVP-------VSNTPVASSEASILSTTPVDSNTPLTTS 3256 Query: 799 DQDQQGIPSCPGEGWIRGAASEWPL-LSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKE 857 + P+ G SE L+S + A ETS P Sbjct: 3257 TEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYS 3316 Query: 858 TSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTP--T 915 + S P D + +P + + P + + TLS TP T Sbjct: 3317 QASSSPPIADGTS------MPTSTYSEGSTPL---TNMSFSTTPVVSSEASTLSTTPVDT 3367 Query: 916 SSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLA 975 S+P E+SL +PT A G P + +G + S P + S Sbjct: 3368 STPVTTSTEASL-------SPT----TAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEV 3416 Query: 976 GNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPL--WGLSKR 1033 S P S + + E S A S ++G +PL LS Sbjct: 3417 NTLSTT--------PVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTT 3468 Query: 1034 EMASGNTGEAPPCQPD-SVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQP 1092 +AS D S + + P + A PT A E P Sbjct: 3469 PVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTP 3528 Query: 1093 VPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGE 1152 V + + A++ + +P +F ++ Q + A + P + G Sbjct: 3529 VASSE------ASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSE-------GS 3575 Query: 1153 ATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFST 1212 ++L+ LL + + +S EAST P D P + ST ST Sbjct: 3576 SSLTTMLLSSTYVTSS--EAST-----------PSTPSVDRSTP------VTTSTQSNST 3616 Query: 1213 HQAVPDPKELL---LSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPC 1269 P P E++ +S P EV+ P T + S ++G + D P + Sbjct: 3617 ----PTPPEVITLPMSTPSEVSTPLT--IMPVSTTSVTISEAGTASTLPVDTSTPVITST 3670 Query: 1270 PVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMP 1327 V P+ E G+ P+ P + G P + + ++EG S P Sbjct: 3671 QVSSSPVTPE---------GTTMPIWTP--SEGSTPLTTMPVSTTRVTSSEGSTLSTP 3717 Score = 35.4 bits (80), Expect = 0.84 Identities = 89/459 (19%), Positives = 148/459 (32%), Gaps = 45/459 (9%) Query: 18 TPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLD--PCLVSP 75 TP + +S + P S ++ + SV + S +++L P S Sbjct: 1071 TPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSI 1130 Query: 76 EVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQT 135 VT + EG+ +P+ PPS E P +SMP + A+ + +T Sbjct: 1131 PVTTSTEASSSPTTAEGTSIPTSPPS-EGTTPLASMPVSTTLVVSSEANTLSTTPVDSKT 1189 Query: 136 QSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGID 195 Q A + P A +STP + + S P + S+ S +S +D Sbjct: 1190 QVATSTEASSPP---PTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLS-TSPVD 1245 Query: 196 QSPGMSPVPL-REPMKAPLCGEGDQ-PGGFESQEKEAAGGFP-----------------P 236 S +PV E +P EG P S+ P P Sbjct: 1246 TS---TPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTP 1302 Query: 237 AESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAP 296 +++ V + +P A +GT P+ IP + AS P Sbjct: 1303 VDTKGPVVTSNEVSSSPTPA-EGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTP 1361 Query: 297 PQYLTDDLEFLRACHLPRSNSGAA-PEAEVNAASQESCQQPVGAYLPHAELPWGLPSPAL 355 T AC P ++ G + P + + + PV +P + Sbjct: 1362 VDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVST------------TPVV 1409 Query: 356 VPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEE 415 EA +DT + + + EG P+ P TP Sbjct: 1410 SSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVAN 1469 Query: 416 AHPASSLASFPA-AQIPIAVEEPGSSSRESVSKAGMPVS 453 + AS+L++ P + P+ SSS + +S Sbjct: 1470 SE-ASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAIS 1507 Score = 32.7 bits (73), Expect = 5.4 Identities = 264/1453 (18%), Positives = 450/1453 (30%), Gaps = 230/1453 (15%) Query: 9 DNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASL 68 D++ ++ T S+ PP N P S ++ + S+ + AS +++L Sbjct: 478 DSKTQVTTSTEASSSPPTAEVN------SMPTSTPSEGSTPLTSMSVSTMPVASSEASTL 531 Query: 69 D--PCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPA 126 P S VT + + PEG+ +P+ PS E P ++MP + Sbjct: 532 STTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPS-EGSTPLTNMPVST----------- 579 Query: 127 AAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKS 186 + + A S+TP V ++ + + Sbjct: 580 ----------------------RLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGT 617 Query: 187 SFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASV 246 S S+ ++ ++ + + + A S E P + S Sbjct: 618 SMPTSTYSERGTTITSMSVSTTLVA-------------SSEASTLSTTPVDSNTPVTTST 664 Query: 247 QVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEF 306 + T + A +S E S P+ +P + AS P T Sbjct: 665 EATSSSTTAEGTSMPTSTYTEGS--TPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTS 722 Query: 307 LRACHLPRSNSGAA-PEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKE 365 A P + GA+ P + + S PV L + L + L + Sbjct: 723 TEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPL-----DTSTH 777 Query: 366 ALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPV------SPEPSLL--TPTEEAH 417 + + P T + P + + G +PV SPE S L TP + Sbjct: 778 ITTSTEASCSPTTTEGTSMP--ISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNS 835 Query: 418 PASSLASFPAAQIPI-AVEEPGSSSRES-VSKAGMPVSADAAKEVVDAGLVGLERQVSDL 475 P ++ ++ P P S+ E MPVS V + + L D Sbjct: 836 PVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTL---VATSAISTLSTTPVDT 892 Query: 476 GSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPL 535 + P + E + G + T PG PL P + P + Sbjct: 893 ST----PVTNSTEARSSPTTSEGTSMPTS-----TPGEGSTPLTS------MPDSTTPVV 937 Query: 536 PKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQ 595 + P + ++TS EG+ P +P E P + Sbjct: 938 SSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTP---SEGTTPLTSTPVSHTL 994 Query: 596 GEDSQAFS------SKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHS 649 +S+A + P E S P AE P+S P +G T P S Sbjct: 995 VANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTS----TPSEGSTPLTRMPVS 1050 Query: 650 QT--AEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGS----GLQPKCPDTLQS 703 T A ++ S L + + + T +G S G P + + Sbjct: 1051 TTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVST 1110 Query: 704 REGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPR 763 R L + SE S TPV P E++ + +G + TSP Sbjct: 1111 R---------LVVSSEASTLSTTPVDTSIPVTTSTEAS---SSPTTAEGTSIPTSP---- 1154 Query: 764 GPACDASRQEFHAGVPHPPQGENLAADLGL-TALILDQDQQGIPSCPGEGWIRGAAS--- 819 P +G A + + T L++ + + + P + + A S Sbjct: 1155 -----------------PSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEA 1197 Query: 820 EWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQG---ADSSQIH 876 P ++E P+ E S P E S D S++ Sbjct: 1198 SSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETS 1257 Query: 877 VPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTL------SDTPTSSPTDMVWESSLTEE 930 E +LPT E GS L + +P T + T ++P D +T Sbjct: 1258 SSPTTAEGTSLPTSTTSE---GSTLLTSIPVSTTLVTSPEASTLLTTPVD-TKGPVVTSN 1313 Query: 931 SELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGP 990 S+PT PA G P +G++ S P L S S + Sbjct: 1314 EVSSSPT----PAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVT 1369 Query: 991 NKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDS 1050 ++ + EG+ S ++G +PL + P Sbjct: 1370 TSTEACSSPTTSEGTSMPN--------SNPSEGTTPLTSIPV---------STTPVVSSE 1412 Query: 1051 VALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQ-KMECWATSDAE 1109 + L A P + ++PG T + E + T EG P P + K + + Sbjct: 1413 ASTLSATP----VDTSTPGTT----SAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSN 1464 Query: 1110 SPKLLASFPSAGEQGGEAGAAETGGSAGAGDP----GKQQAPEKPGEATLSCGLLQTEHC 1165 +P + + ++ + +A + P G A P E + + + Sbjct: 1465 TPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTT 1524 Query: 1166 LTSGEE----ASTSALRESCQAEHPMASCQDALLPAREL-------GGIPRSTMDFSTHQ 1214 + E ++T A+ + + AS + G P +++ ST Sbjct: 1525 TVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTML 1584 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEP 1274 V L + P + T ++++ AE S + +S+ +P + PV Sbjct: 1585 VVSSEANTLSTTPIDSKTQVT--ASTEASSSTTAEGSSM-TISTPSEGSPLLTSIPVSTT 1641 Query: 1275 PLALENAASLKLF-AGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMP 1333 P+A A++L S +P++ P + P + TEG R P Sbjct: 1642 PVASPEASTLSTTPVDSNSPVITSTEVSSS-PTPAEGTSMPTSTYTEG---------RTP 1691 Query: 1334 LLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVD 1393 L T T + A ++ D + S E P+ +GTS Sbjct: 1692 L-------TSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPT--TSEGTSMPNS 1742 Query: 1394 TSSEQIATLTGFP 1406 T SE LT P Sbjct: 1743 TPSEGTTPLTSIP 1755 Score = 32.0 bits (71), Expect = 9.3 Identities = 121/647 (18%), Positives = 194/647 (29%), Gaps = 79/647 (12%) Query: 1 MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCT 60 + + +++ + + P + +S + P S ++ + S+ + Sbjct: 2763 VASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPV 2822 Query: 61 ASESSASLD--PCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPP 118 AS + +L P S VT K EG ++P S E +S+P + P Sbjct: 2823 ASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTAS-EGSTLLTSIPVSTTPV 2881 Query: 119 EGCLASP-AAAPEDG--PQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEI--AAVPSA 173 AS + P D P T S +P + + STP I + VP A Sbjct: 2882 ASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVA 2941 Query: 174 GRERQPKEEGQ-------KSSFSFSSGIDQSPGMS-PVPLREPMKAPLCGEGDQPGGFES 225 G E +S SS + G S P+ + PL S Sbjct: 2942 GSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVAS 3001 Query: 226 QEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRA 285 E P S S + + A G S E S P+ IP P A Sbjct: 3002 SEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGST--PLTSIPVSTTPVA 3059 Query: 286 SDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQ--ESCQQPVGAYLPH 343 P SNS EV+++ E P+ Y Sbjct: 3060 IPEASTLSTTPVD----------------SNSPVVTSTEVSSSPTPAEGTSMPISTYSEG 3103 Query: 344 AELPWGLP---SPALVPEAGGSGKEALDT-------IDVQGHPQTGMRGTKPNQVVCVAA 393 + G+P +P +DT + P T + P + Sbjct: 3104 STPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTP--SE 3161 Query: 394 GGQPEGGLPVSP------EPSLL--------TPTEEAHPASSLASFPAAQIPIAVEEPGS 439 G P +PVS E S L TP + A+S + IP + G Sbjct: 3162 GSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGM 3221 Query: 440 SSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGE 499 + SV + PV++ A + + + + P + +P +P E Sbjct: 3222 TPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGST 3281 Query: 500 HLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAP----SESARGPP---GPTDG 552 L + P S E + P P S+++ PP G + Sbjct: 3282 PLTS----------MPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMP 3331 Query: 553 AKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDS 599 + + ++P S +P S + P D P E S Sbjct: 3332 TSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEAS 3378 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 90.5 bits (223), Expect = 2e-17 Identities = 247/1175 (21%), Positives = 392/1175 (33%), Gaps = 197/1175 (16%) Query: 1247 GAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPA 1306 G DS + SS+ E V + + ++ + A AP PG G P Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA--PGKVGDVTPQ 251 Query: 1307 VQASSGSPKART------TEGPVDSMPCLDRMPLLAKGKQATGEE----KAATAPGAGAK 1356 V+ + P R +E + + P + + E+ +AA+AP G Sbjct: 252 VKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP 311 Query: 1357 ASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSE--------QIATLTGFPDF 1408 G A S + G+P +D + + D+ E Q Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371 Query: 1409 REHIAKIFEKPVLGALATPGEKAG--AGRSAVGK-------------------DLTRPLG 1447 A E P GA P K G ++ GK +P G Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431 Query: 1448 --PEKLLDGPPGVDVT---LLPAPP-------ARLQVEKKQQLA------GEAEISHLAL 1489 P+ P + PAPP A++QV K+++ + +++ LA Sbjct: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 1490 QDPASDKLLGPAGLTWERNLPGAG-VGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQ 1548 + A K LG + + G G +GK VPP P W E + S Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW---EEDSESS 548 Query: 1549 LERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDS 1608 E S +P+ A + Q P S + Q P Q + D+ Sbjct: 549 SEESSDSSDGEVPTAVAPAQ-EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDN 607 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 + D A + P + A + + L +P+ + P +T + V G Sbjct: 608 SESSEESSDSADS---EEAPAAMTA-AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGT 663 Query: 1669 LEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGD-----ITLSTAETQACASGD 1723 R A G ++PA + VA P + + ++ E++ + + ++ + ++ G Sbjct: 664 QAPRKA-GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722 Query: 1724 LPEAGTTRTFSVVAGDL------VLPGSCQDPACSDKAPGMEGTAALHGDSPA------- 1770 +A + V G L VLPG KA E + + +S + Sbjct: 723 QVKAASV----PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778 Query: 1771 -------RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP 1823 + QAK P R P+ G + S P T + + +P ++ +P Sbjct: 779 AQVKTSVKKTQAKANPAAAR-APSAKGTI---SAPGKVVTAAAQAKQRSPSKVKPPVRNP 834 Query: 1824 R------PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESP 1877 + GP+ +PSV K A + +E G+ ES ++ E+ Sbjct: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD------------SEEEAE 882 Query: 1878 TLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCP 1937 TLA G Q+ L SP A PP + PS Sbjct: 883 TLAQVKPSGK-THQIRAALAPAKESPRKGAAPTPPG-----------------KTGPSAA 924 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 K S SEE+ E+ P A PP + +P S P P Sbjct: 925 QAGKQDDSGSSSEESDSDGEA--PAAVTSAQVIKPPLIFVDPNRS----PAGPAATPAQA 978 Query: 1998 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDK-PIASSGTYNLDFDNIELVDTFQTLEPRA 2056 PR S R S S DED P T + + + + + P+A Sbjct: 979 QAASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKA 1035 Query: 2057 --------------SDAKNQEG-KVNTRRKSTDSVPISKSTLSRSLSLQASDFD-----G 2096 SD K QEG +K+ S+P++++ L + L+ +AS+ Sbjct: 1036 SMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAAL-KVLAQKASEAQPPVART 1094 Query: 2097 ASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQE 2156 SSG AV P +T S S K T K R P L + Q K P E Sbjct: 1095 QPSSGVDSAVGTLP---ATSPQSTSVQAKGTNKLRKPKLPEVQQATK----APESSDDSE 1147 Query: 2157 PDEESLVPSGENLASETKTESAKTEGPSPA----LLEETPLEPA----VGPKAACPLDSE 2208 +S S E+ +SA T GP+P+ L+EET E + V P + L Sbjct: 1148 DSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSL-LSGY 1206 Query: 2209 SAEGVVPPASGGGRVQ---NSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRL 2265 G+ P S + +S P TL P+ G QE P + + Sbjct: 1207 MTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD---------GKQEAKPQQAAGMLS 1257 Query: 2266 EFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLR 2300 ++ +S Q++ P K G + + L+ Sbjct: 1258 PKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQ 1292 Score = 81.3 bits (199), Expect = 1e-14 Identities = 296/1419 (20%), Positives = 459/1419 (32%), Gaps = 284/1419 (20%) Query: 8 SDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSAS 67 S N L A P S + ++ K T S H + L G + S Sbjct: 107 STNSSVLGADLPSSMKEKAKAET--EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164 Query: 68 LDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLA-SPA 126 + LVS E GA G + S + SSS E EG + PA Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSS---DETDVEGKPSVKPA 221 Query: 127 AAPEDGPQT-QSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQK 185 T +SP R+ AP APG + TP + A+P A R ++P+EE + Sbjct: 222 QVKASSVSTKESPARKAAP-APGKVGDV--------TPQVKGGALPPAKRAKKPEEESES 272 Query: 186 SSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVAS 245 S G ES+E+ AG ++ + + Sbjct: 273 SE---------------------------------EGSESEEEAPAGTRSQVKASEKILQ 299 Query: 246 VQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLE 305 V+ A +A +GT P K A Q A + + E+ + +D E Sbjct: 300 VR----AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSESSSEESSDSEE 351 Query: 306 FLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKE 365 A + ++V AAS + + P P P G PA+ G +E Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP---APPGKTGPAVAKAQAGKREE 408 Query: 366 ALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP---VSPEPSLLTPTEEAHPASSL 422 + + + A +P G P + P+ +P + A PA Sbjct: 409 DSQSSSEESDSEEE-----------APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457 Query: 423 ASFP-AAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH 481 + P AAQ+ + +E SR S ++ A AA +G QV + G Sbjct: 458 KTGPAAAQVQVGKQE--EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG 515 Query: 482 PEG------DPGEVPAPSPQ------ERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPG 529 P G PG+V +P E ++E+S + G P + Q + Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575 Query: 530 APPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGG 589 P S A+GPP V + P E S DS EEAP Sbjct: 576 LQAKP----TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-ADSEEAPAAMTA- 629 Query: 590 DPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHS 649 +QA + + P+ K K ++ A ++ P Q PRK G T S Sbjct: 630 ---------AQAKPALKIPQT-KACPKKTNTTASAKVAPVRVGTQAPRKAGTA-TSPAGS 678 Query: 650 QTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGR 709 A A + P + + G A G GLQ K ++ + LG+ Sbjct: 679 SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAA-SVPVKGSLGQ 737 Query: 710 MESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDA 769 T PT A K ++ ES+ E D E SP Q + Sbjct: 738 G----TAPVLPGKTGPTVTQVKAEKQEDSESSEE-----ESDSEEAAASPAQVK------ 782 Query: 770 SRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKH 829 V N AA +A +G S PG+ + AA++ S K Sbjct: 783 ------TSVKKTQAKANPAAARAPSA-------KGTISAPGK--VVTAAAQAKQRSPSK- 826 Query: 830 LQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPT 889 ++P P+ S + + A P GK A ++ P+ED+ Sbjct: 827 VKPPVRNPQNSTV-LARGPASVPSVGK-------------AVATAAQAQTGPEEDS---- 868 Query: 890 HGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRP 949 G E+ SE +++ TL+ S T + R L E Sbjct: 869 -GSSEEESDSEEEAE----TLAQVKPSGKTHQI---------------RAALAPAKESPR 908 Query: 950 EGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEE 1009 +GA +PP GP+ +Q D S+ + Sbjct: 909 KGAA-------PTPPGK---------------------TGPSAAQAGKQDDSGSSSEESD 940 Query: 1010 ACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPG 1069 + P A +A P N A P PA A A+ Sbjct: 941 SDGEAPAAVTSAQVIKP-----PLIFVDPNRSPAGPA------------ATPAQAQAAST 983 Query: 1070 VTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGA 1129 + + T ++ + +PA Q T+ P + P + AGA Sbjct: 984 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP---TAHPRIAPKASMAGA 1040 Query: 1130 AETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMAS 1189 + + S+ D KQ+ P L T+ L +++ +A+ P+A Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAAL-------KVLAQKASEAQPPVAR 1093 Query: 1190 CQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAE 1249 Q + +G +P ++ ++ QA G ++ P P + + A ++ Sbjct: 1094 TQPSSGVDSAVGTLPATSPQSTSVQA---------KGTNKLRKPKLPEVQQATKAPESSD 1144 Query: 1250 DSGVKAVSSADPRAPGE-----------SPCPVGEPPLALENAA----------SLKLFA 1288 DS + SS+ GE P P L E AA S L + Sbjct: 1145 DSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLS 1204 Query: 1289 GSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAA 1348 G + P L P + QAS +PK +DS P + LA G+++A Sbjct: 1205 GYMTPGLTPANS-------QASKATPK-------LDSSPSVS--STLAAKDDPDGKQEAK 1248 Query: 1349 TAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 AG + G A+G T + S+ PK+G Sbjct: 1249 PQQAAGMLSPKTGGKEAASGTTP-------QKSRKPKKG 1280 Score = 76.6 bits (187), Expect = 3e-13 Identities = 289/1345 (21%), Positives = 434/1345 (32%), Gaps = 175/1345 (13%) Query: 251 EAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDD-LEFLR 308 EA A + T A S L P +A + G+ G + P T + L Sbjct: 93 EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLL 152 Query: 309 ACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALD 368 + PR + A P A S+ + V A+ A+ G+ S + + D Sbjct: 153 SGKSPRKS--AEPSANTTLVSETEEEGSVPAFGAAAKP--GMVSAGQADSSSEDTSSSSD 208 Query: 369 TIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLL---TPTEE--AHPASSLA 423 DV+G P KP QV + + +P P + TP + A P + A Sbjct: 209 ETDVEGKPSV-----KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263 Query: 424 SFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPE 483 P + + E GS S E + AG A+++++ + + P Sbjct: 264 KKPEEESESS--EEGSESEEE-APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320 Query: 484 GDPGEVP----APSPQERGEHLNTEQS--HEVQPGVPPPPLPKEQSHEVQPGAPPPPLPK 537 G G V A P+E E + E S E P K Q GA P + Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380 Query: 538 APSESAR-GPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQG 596 +P + A PPG T PAVAK + GK E Sbjct: 381 SPRKGAAPAPPG----------KTGPAVAK--------AQAGKRE--------------- 407 Query: 597 EDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADA 656 EDSQ+ S + D E +KPS A S+ + + PRKG A P +T A A Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---PAPPRKTGPAAA 464 Query: 657 SGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWE---GSGLQPKCPDTLQSREGLGRMESF 713 K E+ D E A G Q K T+ G+G + Sbjct: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM----GMGPLGKG 520 Query: 714 LTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGE-GLLTSPDQPRGPACDASRQ 772 P TP A+V ++ ES+ E S DGE +P Q + + Sbjct: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 773 EFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQP 832 + PPQ A +D + S + E P + +P Sbjct: 580 PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-----ADSEEAPAAMTAAQAKP 634 Query: 833 SQAQPET-------------SIFDVLKEQAQPPENGKETSP--SHP----GFKDQGADSS 873 + P+T + V P + G TSP S P G + DSS Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694 Query: 874 QIHVPVEPQEDNNLPTHGGQEQALGSELQ---------SQLPKGTLSDTP-TSSPTDMVW 923 +E L GQ +++G LQ L +GT P + PT Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754 Query: 924 ESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKET 983 ++ E+SE S A ++ +P AA + S G S Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA---RAPSAKGTIS---- 807 Query: 984 CCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEA 1043 P K A A A + + R+P S +A G Sbjct: 808 -----APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTV--------------LARG----- 843 Query: 1044 PPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECW 1103 P SV + A A P E+++ +E + Q ++ Sbjct: 844 ----PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA 899 Query: 1104 ATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTE 1163 ESP+ A+ G+ G A A +G+ E P T S +++ Sbjct: 900 LAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT-SAQVIKPP 958 Query: 1164 HCLTSGEEASTSALRESCQAEHPMASCQDALLP--ARELGGIPRSTMDFSTHQAVPDPKE 1221 + QA Q A P AR RS+ S + V + Sbjct: 959 LIFVDPNRSPAGPAATPAQA-------QAASTPRKARASESTARSSSSESEDEDVIPATQ 1011 Query: 1222 LLLSG--PPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALE 1279 L G V P A+ GA S + S + G + + P +L Sbjct: 1012 CLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLP 1071 Query: 1280 -NAASLKLFAGSLAPLLQPGA----------AGGEIPAVQASSGSPKARTTEGPVDSMPC 1328 A+LK+ A + P A A G +PA S S +A+ T P Sbjct: 1072 LTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKL--RKPK 1129 Query: 1329 LDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGT 1388 L + K +++ + + ++ +G++ GEG G + T G E + Sbjct: 1130 LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAE 1189 Query: 1389 SGGVDTSSEQIATLTGF--PDFREHIAKIFE-KPVLGALATPGEKAGAGRSAVGKDLTRP 1445 S D + + L+G+ P ++ + P L + + A GK +P Sbjct: 1190 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1249 Query: 1446 LGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTW 1505 +L G P + + KK AG + S LALQ + LLG W Sbjct: 1250 QQAAGMLSPKTGGKEAASGTTPQKSRKPKKG--AGNPQASTLALQSNITQCLLGQ---PW 1304 Query: 1506 ERNLPGAGVGKEMAGVPPTLREDER 1530 N A V + V L E ER Sbjct: 1305 PLN--EAQVQASVVKVLTELLEQER 1327 Score = 68.2 bits (165), Expect = 1e-10 Identities = 203/962 (21%), Positives = 326/962 (33%), Gaps = 195/962 (20%) Query: 1529 ERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEA 1588 E P A PG G Q++ A P E E + + + AP + Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291 Query: 1589 VAQDRIPSGKQHQETSACDSPHGEDGPGDF-AHTGVPGHVPRSTCAPSPQREVLTVPEAN 1647 A ++I Q +A G G G A G G V T A P+ + + E + Sbjct: 292 KASEKIL-----QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346 Query: 1648 SEPWTLDTLGGERRPGVTAGILEMR-----NALGNQSTPAPPTGEVADTPLEPGKVAGAA 1702 S+ E +L+ + + +G S PA + P PGK A Sbjct: 347 SD--------SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398 Query: 1703 GEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTA 1762 +A+ +++ + S EA P + S KAP + + Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEA---------------PAQAKP---SGKAPQVRAAS 440 Query: 1763 ALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRES 1822 A +SP + P P R +V V E + + EE +DRE+ Sbjct: 441 APAKESPRKGAA----PAPPRKTGPAAAQVQVGKQEEDSRS--------SSEESDSDREA 488 Query: 1823 PRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPA--------DL 1874 + P +P+V K S G G + PV + PA P+ D Sbjct: 489 -LAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545 Query: 1875 ESPTLAAS-SYHGDVVGQV------STDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGD 1927 ES + +S S G+V V S I Q+ P ++ A PP A P Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-KPTSSPAKGPPQKA-------GPVAV 597 Query: 1928 RVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPP 1987 +V+A P D ++ SSDS ++ E P + T +A PA P + P+ +T Sbjct: 598 QVKAEKPM--DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT---- 651 Query: 1988 EEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 2047 ++ PV G ++ G+ P S P + GT Sbjct: 652 ----ASAKVAPVRVGTQAPRKAGTATSPAGSS---------PAVAGGT------------ 686 Query: 2048 TFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAV 2106 + A D+ + E + K+ +V + ++ ++ + L ++A+ S G A Sbjct: 687 -----QRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741 Query: 2107 ALAPDAYSTGSSSASST-LKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPS 2165 L G + + T +K K+ S +++ +++ +P +T + + P+ Sbjct: 742 VL------PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795 Query: 2166 GENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQN 2225 S T SA P AA S V PP QN Sbjct: 796 AARAPSAKGTISA----------------PGKVVTAAAQAKQRSPSKVKPPVR---NPQN 836 Query: 2226 SPPVGRKTLPLTTAPEA-GEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPP 2284 S + R + + +A + +G +EDS + SE++S + + E Sbjct: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-----------SEEESDSEEEAETLA 885 Query: 2285 PTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDD 2344 K GK + L K PR A P P G K DD Sbjct: 886 QVKPSGKTHQIRAALAPAK-------------ESPRKGAAPTP-PGKTGPSAAQAGKQDD 931 Query: 2345 PNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASA 2404 + S S E+P + P VDP +++P+ P+ +PA Sbjct: 932 SGSSSEESDSD-GEAPAAVTSAQVIKPPLI--FVDP----NRSPAGPAATPAQ------- 977 Query: 2405 MEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISA 2464 A+ TP K R +S RS S+ +D PA TP + + Sbjct: 978 --------------AQAASTPRKA---RASESTARSSSSESEDEDVIPATQCLTPGIRTN 1020 Query: 2465 VV 2466 VV Sbjct: 1021 VV 1022 >gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo sapiens] Length = 1411 Score = 90.5 bits (223), Expect = 2e-17 Identities = 247/1147 (21%), Positives = 384/1147 (33%), Gaps = 196/1147 (17%) Query: 1265 GESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVD 1324 G+SP EP A S GS+ P A G + A QA S S D Sbjct: 154 GKSPRKSAEPS-ANTTLVSETEEEGSV-PAFGAAAKPGMVSAGQADSSSE---------D 202 Query: 1325 SMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 + D + K + + +AA+AP G G A S + G+P +D Sbjct: 203 TSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDS 262 Query: 1385 KQGTSGGVDTSSE--------QIATLTGFPDFREHIAKIFEKPVLGALATPGEKAG--AG 1434 + + D+ E Q A E P GA P K G Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322 Query: 1435 RSAVGK-------------------DLTRPLG--PEKLLDGPPGVDVT---LLPAPP--- 1467 ++ GK +P G P+ P + PAPP Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT 382 Query: 1468 ----ARLQVEKKQQLA------GEAEISHLALQDPASDKLLGPAGLTWERNLPGAG-VGK 1516 A++QV K+++ + +++ LA + A K LG + + G G +GK Sbjct: 383 GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK 442 Query: 1517 EMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAA 1576 VPP P W E + S E S +P+ A + Sbjct: 443 GAGPVPPGKVGPATPSAQVGKW---EEDSESSSEESSDSSDGEVPTAVAPAQ-EKSLGNI 498 Query: 1577 FQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSP 1636 Q P S + Q P Q + D+ + D A + P + A + Sbjct: 499 LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS---EEAPAAMTA-AQ 554 Query: 1637 QREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPG 1696 + L +P+ + P +T + V G R A G ++PA + VA P Sbjct: 555 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAGGTQRPA 613 Query: 1697 KVAGAAGEAEGD-----ITLSTAETQACASGDLPEAGTTRTFSVVAGDL------VLPGS 1745 + + ++ E++ + + ++ + ++ G +A + V G L VLPG Sbjct: 614 EDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASV----PVKGSLGQGTAPVLPGK 669 Query: 1746 CQDPACSDKAPGMEGTAALHGDSPA--------------RPQQAKEQPGPERPIPAGDGK 1791 KA E + + +S + + QAK P R P+ G Sbjct: 670 TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAAR-APSAKGT 728 Query: 1792 VCVSSPPEPDETHDPKLQHLAPEELHTDRESPR------PGPSMLPSVPKKDAPRVMDKV 1845 + S P T + + +P ++ +P+ GP+ +PSV K A + Sbjct: 729 I---SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 785 Query: 1846 TSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAA 1905 +E G+ ES ++ E+ TLA G Q+ L SP Sbjct: 786 GPEEDSGSSEEESD------------SEEEAETLAQVKPSGK-THQIRAALAPAKESPRK 832 Query: 1906 AHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAP 1965 A PP + PS K S SEE+ E+ P Sbjct: 833 GAAPTPPG-----------------KTGPSAAQAGKQDDSGSSSEESDSDGEA--PAAVT 873 Query: 1966 PAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFD 2025 A PP + +P S P P PR S R S S D Sbjct: 874 SAQVIKPPLIFVDPNRS----PAGPAATPAQAQAASTPRKARASESTARSSS---SESED 926 Query: 2026 EDK-PIASSGTYNLDFDNIELVDTFQTLEPRA--------------SDAKNQEG-KVNTR 2069 ED P T + + + + + P+A SD K QEG Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986 Query: 2070 RKSTDSVPISKSTLSRSLSLQASDFD-----GASSSGNPEAVALAPDAYSTGSSSASSTL 2124 +K+ S+P++++ L + L+ +AS+ SSG AV P +T S S Sbjct: 987 KKNPASLPLTQAAL-KVLAQKASEAQPPVARTQPSSGVDSAVGTLP---ATSPQSTSVQA 1042 Query: 2125 KRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPS 2184 K T K R P L + Q K P E +S S E+ +SA T GP+ Sbjct: 1043 KGTNKLRKPKLPEVQQATK----APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPT 1098 Query: 2185 PA----LLEETPLEPA----VGPKAACPLDSESAEGVVPPASGGGRVQ---NSPPVGRKT 2233 P+ L+EET E + V P + L G+ P S + +S P T Sbjct: 1099 PSRTETLVEETAAESSEDDVVAPSQSL-LSGYMTPGLTPANSQASKATPKLDSSPSVSST 1157 Query: 2234 LPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKP 2293 L P+ G QE P + + ++ +S Q++ P K G Sbjct: 1158 LAAKDDPD---------GKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1208 Query: 2294 VAKMPLR 2300 + + L+ Sbjct: 1209 ASTLALQ 1215 Score = 78.2 bits (191), Expect = 1e-13 Identities = 274/1276 (21%), Positives = 420/1276 (32%), Gaps = 169/1276 (13%) Query: 316 NSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGH 375 ++ + E E A ++ + P A + L LPS ++ +A ++A T + H Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPS-SMKEKAKAETEKAGKTGNSMPH 141 Query: 376 PQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIP--IA 433 P TG V + +G P S +L++ TEE S+ +F AA P ++ Sbjct: 142 PATG------KTVANLLSGKSPRKSAEPSANTTLVSETEEE---GSVPAFGAAAKPGMVS 192 Query: 434 VEEPGSSSRESVSKAG-MPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVP-- 490 + SSS ++ S + V A+++++ + + P G G V Sbjct: 193 AGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 252 Query: 491 --APSPQERGEHLNTEQS--HEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESAR-G 545 A P+E E + E S E P K Q GA P ++P + A Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 312 Query: 546 PPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PPG T PAVAK + GK E EDSQ+ S + Sbjct: 313 PPG----------KTGPAVAK--------AQAGKRE---------------EDSQSSSEE 339 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGE 665 D E +KPS A S+ + + PRKG A P +T A A K E Sbjct: 340 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---PAPPRKTGPAAAQVQVGKQEE 396 Query: 666 EDPVLPPVPDGAGEPTVPEGAIWE---GSGLQPKCPDTLQSREGLGRMESFLTLESEKSD 722 + D E A G Q K T+ G+G + Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM----GMGPLGKGAGPVPPGKV 452 Query: 723 FPPTPVAEVAPKAQEGESTLEIRKMGSCDGE-GLLTSPDQPRGPACDASRQEFHAGVPHP 781 P TP A+V ++ ES+ E S DGE +P Q + + + P Sbjct: 453 GPATPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP 511 Query: 782 PQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPET-- 839 PQ A +D + S + E P + +P+ P+T Sbjct: 512 PQKAGPVAVQVKAEKPMDNSESSEESSDS-----ADSEEAPAAMTAAQAKPALKIPQTKA 566 Query: 840 -----------SIFDVLKEQAQPPENGKETSP--SHP----GFKDQGADSSQIHVPVEPQ 882 + V P + G TSP S P G + DSS + Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626 Query: 883 EDNNLPTHGGQEQALGSELQ---------SQLPKGTLSDTP-TSSPTDMVWESSLTEESE 932 E L GQ +++G LQ L +GT P + PT ++ E+SE Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686 Query: 933 LSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNK 992 S A ++ +P AA + S G S P K Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA---RAPSAKGTIS---------APGK 734 Query: 993 SQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVA 1052 A A A + + R+P S +A G P SV Sbjct: 735 VVTAAAQAKQRSPSKVKPPVRNPQNSTV--------------LARG---------PASVP 771 Query: 1053 LLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPK 1112 + A A P E+++ +E + Q ++ ESP+ Sbjct: 772 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPR 831 Query: 1113 LLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEA 1172 A+ G+ G A A +G+ E P T S +++ + Sbjct: 832 KGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT-SAQVIKPPLIFVDPNRS 890 Query: 1173 STSALRESCQAEHPMASCQDALLP--ARELGGIPRSTMDFSTHQAVPDPKELLLSG--PP 1228 QA Q A P AR RS+ S + V + L G Sbjct: 891 PAGPAATPAQA-------QAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTN 943 Query: 1229 EVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALE-NAASLKLF 1287 V P A+ GA S + S + G + + P +L A+LK+ Sbjct: 944 VVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVL 1003 Query: 1288 AGSLAPLLQPGA----------AGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAK 1337 A + P A A G +PA S S +A+ T P L + K Sbjct: 1004 AQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKL--RKPKLPEVQQATK 1061 Query: 1338 GKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSE 1397 +++ + + ++ +G++ GEG G + T G E + S D + Sbjct: 1062 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1121 Query: 1398 QIATLTGF--PDFREHIAKIFE-KPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDG 1454 + L+G+ P ++ + P L + + A GK +P +L Sbjct: 1122 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1181 Query: 1455 PPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGV 1514 G P + + KK AG + S LALQ + LLG W N A V Sbjct: 1182 KTGGKEAASGTTPQKSRKPKKG--AGNPQASTLALQSNITQCLLGQ---PWPLN--EAQV 1234 Query: 1515 GKEMAGVPPTLREDER 1530 + V L E ER Sbjct: 1235 QASVVKVLTELLEQER 1250 Score = 75.5 bits (184), Expect = 7e-13 Identities = 269/1287 (20%), Positives = 417/1287 (32%), Gaps = 252/1287 (19%) Query: 14 LSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASE-SSASLDPCL 72 LS ++PR + P + + + ++ P A+ G V G ++SE +S+S D Sbjct: 152 LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211 Query: 73 V----SPEVTEPRKDPQGARGPEGS-LLPSPP--------------PSQEREHPS--SSM 111 V S ++ + R A+G G P+PP P ++ E S SS Sbjct: 212 VEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 271 Query: 112 PFAECPPEGCLASPAAAPE-------DGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPY 164 E P L A+ + P +SPR+ AP PG A Sbjct: 272 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA----------- 320 Query: 165 QEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFE 224 A AG+ +EE +SS S +++P + + KAP P E Sbjct: 321 ---VAKAQAGK----REEDSQSSSEESDSEEEAPAQA----KPSGKAPQVRAASAPAK-E 368 Query: 225 SQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESS------AVLEKSPLKPMAPIP 278 S K AA PP ++ A VQV + + ES A + + +KP+ P Sbjct: 369 SPRKGAAPA-PPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 427 Query: 279 Q-DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEV-------NAASQ 330 Q PA G+G P P A P A+V ++S+ Sbjct: 428 QVKPASTMGMGPLGKGAGPVP--------------PGKVGPATPSAQVGKWEEDSESSSE 473 Query: 331 ESCQQPVG----AYLPHAELPWG---LPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGT 383 ES G A P E G P P G K + VQ + M + Sbjct: 474 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG--PVAVQVKAEKPMDNS 531 Query: 384 KPNQVVCVAAGGQ--PEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAV------- 434 + ++ +A + P +P+L P +A P + + A P+ V Sbjct: 532 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 591 Query: 435 ---------------------EEPGSSSRESVS---KAGMPVSADAAKEVVDAGLVGLER 470 E SSS ES S K G+ V+ AK V GL+ Sbjct: 592 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK----GLQV 647 Query: 471 QVSDLGSKGEHPEGD----PGEVPAPSPQERGEHL----NTEQSHEVQPGVPPPPLPKEQ 522 + + + KG +G PG+ Q + E ++E+ + + P K Sbjct: 648 KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTS 707 Query: 523 SHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEA 582 + Q A P ++ PG A SP+ K R+P +S Sbjct: 708 VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 767 Query: 583 PEPPDGGDPGNLQG-------EDSQAFSSKRDPEVGKDELS--KPSSD--------AESR 625 P G EDS + + D E + L+ KPS A ++ Sbjct: 768 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 827 Query: 626 DHPSSHSA-QPPRKGG-----AGHTDGPHSQTAEADASG-LPHKLGEEDPVLPPV--PDG 676 + P +A PP K G AG D S + E+D+ G P + + PP+ D Sbjct: 828 ESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDP 887 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDF------------- 723 P P A P ++ E R S ESE D Sbjct: 888 NRSPAGP--AATPAQAQAASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRT 942 Query: 724 ----PPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVP 779 PT +APKA ++ DG+ + GPA S++ Sbjct: 943 NVVTMPTAHPRIAPKASMAGASSSKESSRISDGK-------KQEGPATQVSKK------- 988 Query: 780 HPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPET 839 +P A L + A + Q + + A P S P + Sbjct: 989 NPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATS------PQSTSVQA 1042 Query: 840 SIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGS 899 + L++ P +P + +DSS +ED P LG Sbjct: 1043 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS-----GSEEDGEGPQGAKSAHTLG- 1096 Query: 900 ELQSQLPKGTLSDTPTSSPTDMVWESSLTEESE--LSAPTRQKLPALGEKRPEGACGDGQ 957 PT S T+ + E + E SE + AP++ L G P + Q Sbjct: 1097 --------------PTPSRTETLVEETAAESSEDDVVAPSQSLLS--GYMTPGLTPANSQ 1140 Query: 958 SSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGA 1017 +S+ +P L + S T P+ Q+A + Q G Sbjct: 1141 ASKATP---------KLDSSPSVSSTLAAKDDPDGKQEA------KPQQAAGMLSPKTGG 1185 Query: 1018 SEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGV----TPT 1073 EAA G +P ++ A Q + L P A V T Sbjct: 1186 KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTEL 1245 Query: 1074 QDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAG----- 1128 + + D T+E ++ + ++K+ A +P+ +GGEA Sbjct: 1246 LEQERKKVVDTTKESSRKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEASVSPEK 1304 Query: 1129 AAETGGSAGAGDPGKQQAPEKPGEATL 1155 + T D EK G+ +L Sbjct: 1305 TSTTSKGKAKRDKASGDVKEKKGKGSL 1331 Score = 59.7 bits (143), Expect = 4e-08 Identities = 243/1219 (19%), Positives = 403/1219 (33%), Gaps = 212/1219 (17%) Query: 1550 ERSRQELASGLPSPAATQ------ELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQET 1603 E + E A P A+T +LP + G+ + +GK Sbjct: 92 EEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANL 151 Query: 1604 SACDSPHGEDGPGD----FAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGE 1659 + SP P + T G VP A P +++SE + + + Sbjct: 152 LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211 Query: 1660 RRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQAC 1719 + IL++R A S PA T TP PGK A + + +E+ + Sbjct: 212 VEVKASEKILQVRAA----SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE 267 Query: 1720 ASGDLPE---AGTTRTFSVVAGDLVLPGSCQDPA-------CSDKAPGMEGTAALHGDSP 1769 S D E A + +G G+ PA + PG G A + Sbjct: 268 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 327 Query: 1770 ARPQQAK----------EQPGPERP-----------IPAGDGKVCVSSPPEPDETHDPKL 1808 R + ++ E P +P PA + ++P P +T Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 387 Query: 1809 QHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAE-------GTESSPV 1861 Q ++ R S S ++ +A +V S + + A G + PV Sbjct: 388 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 447 Query: 1862 ADDIIQPAAPA--------DLESPTLAAS-SYHGDVVGQV------STDLIAQSISPAAA 1906 + PA P+ D ES + +S S G+V V S I Q+ P ++ Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-KPTSS 506 Query: 1907 HAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPP 1966 A PP A P +V+A P D ++ SSDS ++ E P + T +A P Sbjct: 507 PAKGPPQKA-------GPVAVQVKAEKPM--DNSESSEESSDSADSEEAPAAMTAAQAKP 557 Query: 1967 APPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDE 2026 A P + P+ +T ++ PV G ++ G+ P S + Sbjct: 558 ALKIPQTKACPKKTNTT--------ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT 609 Query: 2027 DKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNT------------------ 2068 +P S + E T+ S K + K + Sbjct: 610 QRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 669 Query: 2069 RRKSTDSVPISKSTLSRSLSLQASDFDGASSS--------------GNPEAVALAPDAYS 2114 + V K S S S + SD + A++S NP A A AP A Sbjct: 670 TGPTVTQVKAEKQEDSES-SEEESDSEEAAASPAQVKTSVKKTQAKANP-AAARAPSAKG 727 Query: 2115 TGSS-------SASSTLKRTKKPRPPSLKKKQTT---KKPTETPPV-------KETQQEP 2157 T S+ +A + + K +PP + +T + P P V + Q P Sbjct: 728 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787 Query: 2158 DEESLVPSGENLASETKTESAKTEGPSP---------ALLEETPLEPAV-------GPKA 2201 +E+S S E SE + E+ PS A +E+P + A GP A Sbjct: 788 EEDS-GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 846 Query: 2202 A---------CPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGG 2252 A + ++G P A +V P + P P+ + Sbjct: 847 AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI-------FVDPNRSPAGPAATPA 899 Query: 2253 QEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG---KKPVAKMPLRRPKMKKTPE 2309 Q + + R + SS ++ P T+ + + V MP P++ Sbjct: 900 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP--- 956 Query: 2310 KLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNF 2369 K AS + + +D +G T K NP S L Q++ Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKK------NPASLPLTQAALKVLAQKASEA 1010 Query: 2370 DPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTD 2429 P ++T S A +PA++ ++ V G NK K K ++ Sbjct: 1011 QPPV-----------ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1059 Query: 2430 TFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVD-- 2487 T K+P+ S S+ S + + P + H L T + + + Sbjct: 1060 T----KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT-----LGPTPSRTETLVEETA 1110 Query: 2488 LEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDD------- 2540 E+ + D PS T +P + + +++ + S+L DD Sbjct: 1111 AESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEA 1170 Query: 2541 APKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVN--TAAKNQHPVPRG 2598 P++ A L T + + + S P +G+ T AL + T P P Sbjct: 1171 KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN 1230 Query: 2599 LAPNQESHLQVPEKSSQKE 2617 A Q S ++V + ++E Sbjct: 1231 EAQVQASVVKVLTELLEQE 1249 >gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens] Length = 1464 Score = 90.1 bits (222), Expect = 3e-17 Identities = 213/886 (24%), Positives = 286/886 (32%), Gaps = 169/886 (19%) Query: 39 PGSPDHR----------DASSIGSVGLGGFCTASESSASLDPCLVSPEVTEP-RKDPQGA 87 PG HR DA G G G + + + P + E P P GA Sbjct: 262 PGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGA 321 Query: 88 RGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQ-------TQSPRR 140 RG +G+ + PP P P G + A E GPQ Q R Sbjct: 322 RGNDGATGAAGPPG----------PTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRG 371 Query: 141 EPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGM 200 EP P PG AA PA + G + QP +G + GI +PG Sbjct: 372 EPGP--PGPAGAAGPAG--------------NPGADGQPGAKGANGA----PGIAGAPGF 411 Query: 201 SPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGT 260 PG + GG P + G P A Sbjct: 412 -------------------PGARGPSGPQGPGGPPGPKGNSG---------EPGAPGSKG 443 Query: 261 ESSAVLEKSPLKPMAPIPQDPAPRASDRERG-QGEAPPQYLTDDLEFLRACHLPRSNSGA 319 ++ A E P+ P P P + +RG +GE P L P G Sbjct: 444 DTGAKGEPGPVGVQGP----PGPAGEEGKRGARGEPGPTGLPGP---------PGERGGP 490 Query: 320 APEAEVNAASQESCQQPVGAY-LPHAELPWGLPSPALVP-EAGGSGKEALDTIDVQGHPQ 377 A + P G P P G P A P EAG G + L Sbjct: 491 GSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL---------- 540 Query: 378 TGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 TG G+ G + G P P P A + + FP + A EP Sbjct: 541 TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPP------GARGQAGVMGFPGPKG--AAGEP 592 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH-PEGDPG----EVPAP 492 G + V G P + A + +AG G G +GE P G PG PA Sbjct: 593 GKAGERGVP--GPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAG 650 Query: 493 SPQERGEHLNTEQSHEVQPGVPPPPLPK-EQSHEVQPGAPPPPLPKAPSESARGPPGPTD 551 P E G+ EQ G P P + E+ + G PP P P A G PG D Sbjct: 651 PPGEAGKP--GEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGP-RGANGAPG-ND 706 Query: 552 GAKVHEDSTSP-AVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK----- 605 GAK D+ +P A +G+ PG + A P GD G+ + + K Sbjct: 707 GAK--GDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRG 764 Query: 606 ------------RDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAE 653 + G+ S P+ +R P +P G AG GP + Sbjct: 765 LTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRG-EPGPPGPAGFA-GPPGADGQ 822 Query: 654 ADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIW----EGSGLQPKCPDTLQSREGLGR 709 A G P G + PP P G P P G + +G+ P GR Sbjct: 823 PGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGR 882 Query: 710 MESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDA 769 + + PP P + K GE+ R GE P P GPA + Sbjct: 883 VGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRP-----GE---VGPPGPPGPAGEK 934 Query: 770 SRQ--EFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSE 827 + AG P P + +A G+ L + ++G P PG G + P +S Sbjct: 935 GSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPG--KQGPSGASG 992 Query: 828 KHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSS 873 + P P P E+G+E +P G G D S Sbjct: 993 ERGPPGPMGPPGL-------AGPPGESGREGAPGAEG--SPGRDGS 1029 Score = 77.0 bits (188), Expect = 3e-13 Identities = 255/1105 (23%), Positives = 351/1105 (31%), Gaps = 172/1105 (15%) Query: 71 CLVSPEVTEPRKD--------PQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPP---- 118 C V P+ +E D P+G GP G P+ PP ++ +P PP Sbjct: 92 CPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPG 151 Query: 119 --------------------EGCLASPAAAPEDGPQ-TQSPRREPAPNA-------PGDI 150 G ++ P GP+ P P P PG+ Sbjct: 152 PPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEP 211 Query: 151 AAAFP-AERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPM 209 A+ P R P + AG+ +P E G + G+ + G+ + Sbjct: 212 GASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGP-QGARGLPGTAGLPGMKGHRGF 270 Query: 210 KAPLCGEGDQ-PGGFESQE-KEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLE 267 +GD P G + + G P +G+ + P AP A A Sbjct: 271 SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGA 330 Query: 268 KSPLKPMAPIPQDPAPRASDRERGQGEAPPQ--YLTDDLEFLRACHLPRSNSGAA-PEAE 324 P P P P A +GEA PQ ++ + +R P +GAA P Sbjct: 331 AGPPGPTGPAGPPGFPGAVG---AKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGN 387 Query: 325 VNAASQESCQQPVGA-------YLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHP- 376 A Q + GA P A P G P P G+ E G P Sbjct: 388 PGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGE-------PGAPG 440 Query: 377 ---QTGMRGTKPNQVVCVA----AGGQPEGGLPVSPEPSLL--TPTEEAHPASSLASFPA 427 TG +G +P V AG + + G P P+ L P E P S FP Sbjct: 441 SKGDTGAKG-EPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGS--RGFPG 497 Query: 428 AQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPG 487 A +A + + R S AG S A +AGL G + GS G P+G G Sbjct: 498 AD-GVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPG--PDGKTG 554 Query: 488 EVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPK----EQSHEVQPGAPPPPLPKAPS--- 540 P P+ Q+ Q GV P PK E + G P PP P+ Sbjct: 555 P-PGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKD 613 Query: 541 --ESARGPPGPTDGA-KVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGE 597 A+GPPGP A + E + + +G P PG EA +P + G PG+L Sbjct: 614 GEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPG---EAGKPGEQGVPGDLGAP 670 Query: 598 DSQAFSSKR--DPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTA--- 652 +R E G P+ + P + A KG AG P SQ A Sbjct: 671 GPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGA----KGDAGAPGAPGSQGAPGL 726 Query: 653 -----EADASGLPHKLGEEDPVLPPVPDGAG------------EPTVPEGAIWEGSGLQP 695 E A+GLP G+ P DG+ P P GA + P Sbjct: 727 QGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGP 786 Query: 696 KCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGL 755 P G PP P P +G+ + + G +G Sbjct: 787 SGPAGPTGARG--------APGDRGEPGPPGPAGFAGPPGADGQPGAK-GEPGDAGAKG- 836 Query: 756 LTSPDQPRGPA--------CDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPS 807 P P GPA A + G PP G G P Sbjct: 837 DAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPG 896 Query: 808 CPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKD 867 PG G + P + +P + P E+ P +G +P PG + Sbjct: 897 PPGPAGKEG--GKGPRGETGPAGRPGEVGPPGPP-GPAGEKGSPGADGPAGAPGTPGPQG 953 Query: 868 QGADSSQIHVPVEPQEDN--NLPTHGGQ--EQALGSELQSQLPKGTLSDTPTSSPTDMVW 923 + +P + E LP G+ +Q + P G + + P Sbjct: 954 IAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPG--- 1010 Query: 924 ESSLTEESELSAPTRQKLPALGEKRPEGACGD-GQSSRVSPPAA----DVLKDFSLAG-N 977 E AP + P G GA GD G++ PP A AG + Sbjct: 1011 -----ESGREGAPGAEGSP--GRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKS 1063 Query: 978 FSRKETCCTG----------QGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPL 1027 R ET G +GP Q D E G Q + + H G S P Sbjct: 1064 GDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPP 1123 Query: 1028 WGLSKREMASGNTGEAPPCQPDSVA 1052 G + SG +G A P P A Sbjct: 1124 -GSPGEQGPSGASGPAGPRGPPGSA 1147 Score = 69.7 bits (169), Expect = 4e-11 Identities = 316/1393 (22%), Positives = 417/1393 (29%), Gaps = 301/1393 (21%) Query: 107 PSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQE 166 P + +P EC P S + ++ + P+ + P P A P RD Sbjct: 82 PGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAG--PPGRDGIPGQPG 139 Query: 167 IAAVPSAGRERQPKEEGQKSSFSFSSGIDQSP--GMS-PVPLREPMKAPLCGEGDQPG-- 221 + P P G + S G D+ G+S P P+ L G PG Sbjct: 140 LPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQ 199 Query: 222 GFESQEKEAAGGFPPAESRQGVASVQVTPEAPAA--AQQGTESSAVLEKSPLKPMAPIPQ 279 GF+ PP E + AS + P P + G + A P +P P Sbjct: 200 GFQG---------PPGEPGEPGASGPMGPRGPPGPPGKNGDDGEA---GKPGRPGERGP- 246 Query: 280 DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSG-AAPEAEVNAASQESCQQPVG 338 P P+ + G P L + ++G A P+ E + + +G Sbjct: 247 -PGPQGARGLPGTAGLPGMKGHRGFSGLDGA---KGDAGPAGPKGEPGSPGENGAPGQMG 302 Query: 339 AYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPE 398 P GLP P A G G RG A G P Sbjct: 303 --------PRGLPGERGRPGAPGPA---------------GARGNDG----ATGAAGPPG 335 Query: 399 GGLPVSPE--PSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADA 456 P P P + EA P Q P E P E G P A A Sbjct: 336 PTGPAGPPGFPGAVGAKGEAGP----------QGPRGSEGPQGVRGEP----GPPGPAGA 381 Query: 457 AKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPS-PQERGEHLNTEQSHEVQPGVPP 515 A + G G G+KG + G PG AP P RG S PG PP Sbjct: 382 AGPAGNPGADGQP------GAKGAN--GAPGIAGAPGFPGARGP------SGPQGPGGPP 427 Query: 516 PPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDS 575 P + + +PGAP A+G PGP V +G P Sbjct: 428 GP----KGNSGEPGAPG----SKGDTGAKGEPGP--------------VGVQGPPGPAGE 465 Query: 576 PGGKEEAPEP-PDG--GDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS 632 G + EP P G G PG G S+ F G D ++ P A R P Sbjct: 466 EGKRGARGEPGPTGLPGPPGERGGPGSRGFP-------GADGVAGPKGPAGERGSPGP-- 516 Query: 633 AQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVP---DGAGEPTVPEGAIWE 689 A P G G +G P G + PP P DG P P GA + Sbjct: 517 AGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQ 576 Query: 690 GSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGS 749 + P G P P V P ++GE+ + Sbjct: 577 AGVMGFPGPKGAAGEPGKAGERGV-----------PGPPGAVGPAGKDGEAGAQ------ 619 Query: 750 CDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPS-- 807 P P GPA + Q G P + L G +QG+P Sbjct: 620 --------GPPGPAGPAGERGEQ----GPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDL 667 Query: 808 -CPGEGWIRGAASEWPLLSSEKHLQ--PSQAQPETSIFDVLKEQAQPPENGKETSPSHPG 864 PG RG E+ +Q P A P + P +G + PG Sbjct: 668 GAPGPSGARGERG----FPGERGVQGPPGPAGPRGA-------NGAPGNDGAKGDAGAPG 716 Query: 865 FK-DQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVW 923 QGA Q +P G G PKG D + P Sbjct: 717 APGSQGAPGLQ-----------GMPGERGAAGLPG-------PKGDRGD---AGPKGADG 755 Query: 924 ESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKET 983 L+ P +G P GA GD S S PA Sbjct: 756 SPGKDGVRGLTGP-------IGPPGPAGAPGDKGESGPSGPA------------------ 790 Query: 984 CCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEA 1043 GP ++ A D E G PGA + G G + + +G G A Sbjct: 791 -----GPTGARGAPGDRGEPGPPGPAGFAGPPGA-DGQPGAKGEPGDAGAKGDAGPPGPA 844 Query: 1044 PPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECW 1103 P P P AP + G + P GR P P P Sbjct: 845 GPAGPPG-------PIGNVGAPGAKGARGSAGPPGATGFPGAA-GRVGP-PGP------- 888 Query: 1104 ATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTE 1163 + +A P AG++GG+ ETG AG PG+ P PG A Sbjct: 889 -SGNAGPP---GPPGPAGKEGGKGPRGETGP---AGRPGEVGPPGPPGPA---------- 931 Query: 1164 HCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIP--RSTMDFSTHQAVPDPKE 1221 GE+ S A A P + R + G+P R F +P P Sbjct: 932 -----GEKGSPGA---DGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGF---PGLPGP-- 978 Query: 1222 LLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENA 1281 SG P P ++ +RG + P G P E + + Sbjct: 979 ---SGEPGKQGPS------GASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGS 1029 Query: 1282 ASLKLFAGSLAPLLQPGAAGGE-IPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQ 1340 K G P PGA G P +G R GP P P+ A+G Sbjct: 1030 PGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAG--PAGPVGPVGARG-- 1085 Query: 1341 ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIA 1400 G + G + G+ G G G P +QG SG + + Sbjct: 1086 PAGPQGPRGDKGETGEQGDRGIKGHRG--FSGLQGPPGPPGSPGEQGPSGASGPAGPR-- 1141 Query: 1401 TLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSA-VGKDLTRPLGPEKLLDGPP--- 1456 G P K + G + PG + G + VG P GP GPP Sbjct: 1142 ---GPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGP--PGPPGP----PGPPGPP 1192 Query: 1457 --GVDVTLLPAPP 1467 G D + LP PP Sbjct: 1193 SAGFDFSFLPQPP 1205 Score = 68.9 bits (167), Expect = 7e-11 Identities = 166/691 (24%), Positives = 217/691 (31%), Gaps = 112/691 (16%) Query: 32 KRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPE 91 K ++ PG P ++G G G E+ A P P + P G+ G + Sbjct: 594 KAGERGVPGPP-----GAVGPAGKDG-----EAGAQGPPGPAGPAGERGEQGPAGSPGFQ 643 Query: 92 GSLLPSPPPSQEREHPSSSMP--FAECPPEGCLASPAAAPEDGPQTQSPRREP--APNAP 147 G P+ PP + + +P P G E G Q P A AP Sbjct: 644 GLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAP 703 Query: 148 GDIAAAFPAERDSSTPYQEIAAVPSAGRERQ----PKEEGQKSSFSFSSGIDQSPGMSPV 203 G+ A A + Q + ER P +G + G D SPG V Sbjct: 704 GNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAG-PKGADGSPGKDGV 762 Query: 204 -----PLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGV---ASVQVTPEA--- 252 P+ P A G+ + G A G P G A P A Sbjct: 763 RGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQ 822 Query: 253 PAAAQQGTESSAVLEKSPLKPMAPI-PQDPAPR--ASDRERGQGEAPPQYLTDDLEFLRA 309 P A + ++ A + P P P P P A + +G A P T Sbjct: 823 PGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGR 882 Query: 310 CHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDT 369 P + A P A +E + P G P A P + P AG G D Sbjct: 883 VGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGP-AGRPGEVGPPGPPGPAGEKGSPGAD- 940 Query: 370 IDVQGHPQT-GMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAA 428 G P T G +G + V G + E G P P PS + AS P Sbjct: 941 -GPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGP 999 Query: 429 QIPIAVE-EPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPG 487 P + PG S RE G G E GS G +GD G Sbjct: 1000 MGPPGLAGPPGESGRE--------------------GAPGAEGSPGRDGSPGA--KGDRG 1037 Query: 488 EVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPP--PLPKAPSESARG 545 E P PG P P GAP P P K+ G Sbjct: 1038 ETGPAGP----------------PGAPGAP-----------GAPGPVGPAGKSGDRGETG 1070 Query: 546 PPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 P GP V G+R P G + + E + GD G ++G + FS Sbjct: 1071 PAGPAG-----------PVGPVGARGPAGPQGPRGDKGETGEQGDRG-IKGH--RGFSGL 1116 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQP---PRKGGAGHTDGPHSQTAEADASGLPHK 662 + P P S E +S A P P GA DG + G + Sbjct: 1117 QGPP------GPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGR 1170 Query: 663 LGEEDPVLPPVPDGAGEPTVPEGAIWEGSGL 693 G+ PV PP P G P P A ++ S L Sbjct: 1171 TGDAGPVGPPGPPGPPGPPGPPSAGFDFSFL 1201 Score = 65.9 bits (159), Expect = 6e-10 Identities = 212/858 (24%), Positives = 272/858 (31%), Gaps = 143/858 (16%) Query: 1225 SGPPEVA-APDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGES--------PCPVGEP- 1274 +G P +A AP P S Q G K +S +P APG P PVG Sbjct: 400 NGAPGIAGAPGFPGARGPSGPQGPGGPPGPKG-NSGEPGAPGSKGDTGAKGEPGPVGVQG 458 Query: 1275 ---PLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDR 1331 P E + G PG GG S G P A GP P +R Sbjct: 459 PPGPAGEEGKRGARGEPGPTGLPGPPGERGGP-----GSRGFPGADGVAGPKG--PAGER 511 Query: 1332 -MPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGE-TEGSMERMGEPSQDPKQGTS 1389 P A K + GE A PG +G+ G +G G QD + G Sbjct: 512 GSPGPAGPKGSPGE---AGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPP 568 Query: 1390 GGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRS--AVGKDLTRPLG 1447 G + A + GFP + + + G PG AG+ A + P G Sbjct: 569 GPPGARGQ--AGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAG 626 Query: 1448 P-----EKLLDGPPGVDVTLLPA-PPARLQVEKKQQLAGEAEI-------------SHLA 1488 P E+ G PG PA PP +Q + G+ Sbjct: 627 PAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERG 686 Query: 1489 LQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQ 1548 +Q P GPAG PG K AG P P GA PGL+G Sbjct: 687 VQGPP-----GPAGPRGANGAPGNDGAKGDAGAPGA------PGSQGA--PGLQGMPG-- 731 Query: 1549 LERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSG-------KQHQ 1601 ER A+GLP P + + A +P G + P G K Sbjct: 732 -ERG----AAGLPGPKGDRGDAGPKGA--DGSPGKDGVRGLTGPIGPPGPAGAPGDKGES 784 Query: 1602 ETSACDSPHGEDG-PGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGER 1660 S P G G PGD G PG P P P + P A EP G Sbjct: 785 GPSGPAGPTGARGAPGDRGEPGPPG--PAGFAGP-PGAD--GQPGAKGEPGDAGAKGDAG 839 Query: 1661 RPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEA-----EGDITLSTAE 1715 PG AG +GN P + P GAAG G+ Sbjct: 840 PPG-PAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPP 898 Query: 1716 TQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQA 1775 A G G T G++ PG PA +PG +G A G +P PQ Sbjct: 899 GPAGKEGGKGPRGETGPAGR-PGEVGPPGP-PGPAGEKGSPGADGPAGAPG-TPG-PQGI 954 Query: 1776 KEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRP-GPSMLPSVP 1834 Q G +P G+ P P + +P Q P +R P P GP L P Sbjct: 955 AGQRGVVG-LPGQRGER--GFPGLPGPSGEPGKQ--GPSGASGERGPPGPMGPPGLAGPP 1009 Query: 1835 ----KKDAPRVMDKVTSDETRGAEGT--ESSPVADDIIQPAAPADLESPTLAASSYHGDV 1888 ++ AP D + GA+G E+ P P AP +P Sbjct: 1010 GESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGP----PGAPGAPGAP---------GP 1056 Query: 1889 VGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSD 1948 VG PA + P A P P GD+ E Sbjct: 1057 VGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETG--------------EQ 1102 Query: 1949 SEEAFETPESTTPVKAPPAPPPPPPEVIPE----PEVSTQPP-----PEEPGCGSETVPV 1999 + + + ++ PP PP P E P P PP P + G P+ Sbjct: 1103 GDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPI 1162 Query: 2000 -PDGPRSDSVEGSPFRPP 2016 P GPR + + P PP Sbjct: 1163 GPPGPRGRTGDAGPVGPP 1180 Score = 63.9 bits (154), Expect = 2e-09 Identities = 259/1070 (24%), Positives = 327/1070 (30%), Gaps = 231/1070 (21%) Query: 1072 PTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAE 1131 P + PE E C +G + P T+ E PK G +G A Sbjct: 82 PGAEVPEGECCPVCPDGSESPTDQE--------TTGVEGPK-----GDTGPRGPRGPAGP 128 Query: 1132 TGGSAGAGDPGKQQAPEKPGE-ATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASC 1190 G G PG P PG G +E ST + PM Sbjct: 129 PGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGI----SVPGPMGPS 184 Query: 1191 QDALLPARELGGIPRSTMDFSTHQAVP-DPKELLLSGPPEVAAPDTPYLHVDSAAQRGAE 1249 LP P Q P +P E SGP P P + + Sbjct: 185 GPRGLPG------PPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGP-------PGKNGD 231 Query: 1250 DSGVKAVSSADPRAPGESPCPVGEPPLALENAASL---------------KLFAGSLAPL 1294 D + P PGE P + L A L K AG P Sbjct: 232 DG-----EAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPK 286 Query: 1295 LQPGAAGGE-IPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGA 1353 +PG+ G P G P R G P A+G G AA PG Sbjct: 287 GEPGSPGENGAPGQMGPRGLPGERGRPGAPG--------PAGARGND--GATGAAGPPGP 336 Query: 1354 GAKASGEGMAG--DAAGE--------TEGSMERMGEPSQDPKQGTSG-----GVD----- 1393 A G G A GE +EG GEP G +G G D Sbjct: 337 TGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGA 396 Query: 1394 ---TSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAV--GKDLTRPLGP 1448 + IA GFP R G PG K +G K T G Sbjct: 397 KGANGAPGIAGAPGFPGARGPSGP------QGPGGPPGPKGNSGEPGAPGSKGDTGAKGE 450 Query: 1449 EKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHL-----------ALQDPASDKL 1497 GP GV PP E K+ GE + L + P +D + Sbjct: 451 P----GPVGVQ-----GPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGV 501 Query: 1498 LGPAGLTWERNLPG----------------AGV--GKEMAGVPPTLREDERPEGPGAAW- 1538 GP G ER PG AG+ K + G P + D + PG A Sbjct: 502 AGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQ 561 Query: 1539 ---------PGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAV 1589 PG GQA + + A+G P A + +P A V P EA Sbjct: 562 DGRPGPPGPPGARGQA-GVMGFPGPKGAAGEPGKAGERGVPGPPGA---VGPAGKDGEAG 617 Query: 1590 AQ----DRIPSGKQHQETSACDSP--HGEDGP-GDFAHTGVPGH--VPRSTCAPSPQREV 1640 AQ P+G++ ++ A SP G GP G G PG VP AP P Sbjct: 618 AQGPPGPAGPAGERGEQGPA-GSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPS--- 673 Query: 1641 LTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAG 1700 A E G + PG AG A GN A P PG G Sbjct: 674 ----GARGERGFPGERGVQGPPG-PAGPRGANGAPGNDGAKGD-----AGAPGAPGS-QG 722 Query: 1701 AAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLV--LPGSCQDPACSDKAPGM 1758 A G +G A GD +AG D V L G P + APG Sbjct: 723 APG-LQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAG-APGD 780 Query: 1759 EGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHT 1818 +G + G PA P A+ PG +R P G + PP D K + P + Sbjct: 781 KGESGPSG--PAGPTGARGAPG-DRGEPGPPGPAGFAGPPGADGQPGAKGE---PGDAGA 834 Query: 1819 DRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDI------IQPAAPA 1872 ++ PGP+ P+ P P + V + +GA G+ P A + P P+ Sbjct: 835 KGDAGPPGPAG-PAGP----PGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPS 889 Query: 1873 DLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSA--PA----- 1925 P G G+ + P PP A SP A PA Sbjct: 890 GNAGPP-GPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGT 948 Query: 1926 ----------------GDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPP 1969 G R E P P P+ E + P + + PP P Sbjct: 949 PGPQGIAGQRGVVGLPGQRGERGFPGLPGPS--------GEPGKQGPSGASGERGPPGPM 1000 Query: 1970 PPPPEVIPEPEVSTQPPPEEPGCGSETVPVPD---GPRSDSVEGSPFRPP 2016 PP P E + P G+E P D G + D E P PP Sbjct: 1001 GPPGLAGPPGESGREGAP-----GAEGSPGRDGSPGAKGDRGETGPAGPP 1045 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 90.1 bits (222), Expect = 3e-17 Identities = 199/862 (23%), Positives = 286/862 (33%), Gaps = 124/862 (14%) Query: 1680 TPAPPTGEVADTPLEPG--KVAGAAG--------EAEGDITLSTAETQACASGDLPEAGT 1729 TP PP P+ P +V GAAG E G I +T A +G AGT Sbjct: 26 TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGT 85 Query: 1730 T------------RTFSVVAGDLVLPGSCQDP--ACSDKAPGMEGTAALHGDSPARPQQA 1775 + R PG P A PG G L + + Sbjct: 86 SSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 145 Query: 1776 KEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPK 1835 K P+R + + S P T P + + T+ PRP PS P P Sbjct: 146 KATEAPKRSALSAGARRDTSGPTPG--TPSPAMARRS-RAAGTEVGLPRPAPSARPRPPT 202 Query: 1836 KDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESP-TLAASSYHGDVVGQVST 1894 + + + + T TE SP A +P+A L+ P + + SS + + Sbjct: 203 EGPRKSVSSASEHST-----TEPSPAARR--RPSAGGGLQRPASRSLSSSATPLSSPARS 255 Query: 1895 DLIAQSISPAAAHAGLPPSAAEHIVSP---------SAPAGDRVEASTPSCPDPAKDLSR 1945 A+ A AH P + P +APA + +S + P P+ +R Sbjct: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKAR 315 Query: 1946 SSDSEEAFETPESTTPVKAPPAPP--------PPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 + TP P PP+PP PP P P + PP P ++ Sbjct: 316 PVPPPDNAATP---LPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSM 372 Query: 1998 PVPDGPRSDSVEGSPFRPPSHSFSA--VFDEDKPIASSG---TYNLDFDNIELVDTFQTL 2052 P S++ P HS ++ + P+A S T +L ++ +F T+ Sbjct: 373 TTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTM 432 Query: 2053 EPRASDAKNQEGKVNTRRKST--DSVPISKS-TLSRSLSLQASDFDGASSSGNPEAVALA 2109 PR + A +R ST DS P+ +L S LQ S S +P + Sbjct: 433 SPRQTQASLTSP---SRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL 489 Query: 2110 PDAYSTGSSSASSTLKRTKKP--------RPPSLKKKQTTKKPTETPPVKETQQEPDEES 2161 S S S + L P PPSL QT TPP++ S Sbjct: 490 QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSL---QTPPASLTTPPLENLP------S 540 Query: 2162 LVPSGENLASETKTESAKTEGPSPALLE-ETPLEPAVGPKAACPLDSESAEGVVPPASGG 2220 L P AS T P PA + P P P P + PPA Sbjct: 541 LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS 600 Query: 2221 GRVQN--SPPVG-----------RKTLPLTTAPEAGEVTPSDSGGQEDSPA--KGLSVRL 2265 +Q SPP+ LP AP + +P S SP L+V L Sbjct: 601 PPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 660 Query: 2266 -EFDYSEDKSSWDNQQENPPPTKKIGKK--PVAKMP--LRRPKMKKTPEKLDNTPASPPR 2320 + +S S +PP + + P ++ P L P ++ P + P SP Sbjct: 661 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 720 Query: 2321 SPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDP 2380 +P P+A P +P S+T + P L P + P Sbjct: 721 TPPPQAPPPLAAPPLQVPPSPPASPPMSP-SATPPPRVPPLLAAPPLQVPPSP--PASLP 777 Query: 2381 FKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRS 2440 +K P P PA P A+ + G + P+ S Sbjct: 778 MSPLAKPP--PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM-------------S 822 Query: 2441 PLSDPPSQDPTPAATP--ETPP 2460 PL+ PP Q P A P + PP Sbjct: 823 PLATPPPQAPPVLAAPLLQVPP 844 Score = 64.3 bits (155), Expect = 2e-09 Identities = 143/623 (22%), Positives = 199/623 (31%), Gaps = 132/623 (21%) Query: 78 TEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQS 137 T P + P P LPSPP S P + P PP SP A+P S Sbjct: 589 TPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASP-----PLS 643 Query: 138 PRREPAPNAPGDIAAAF---PAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGI 194 P P+P AP +A P S P Q + P++ S S + Sbjct: 644 PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS----------PPVSPSATPPS 693 Query: 195 DQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVAS--VQVTPEA 252 P ++ PL+ P P + + PP ++ +A+ +QV P Sbjct: 694 QAPPSLAAPPLQVPPSPP------------ASPPMSPSATPPPQAPPPLAAPPLQVPPSP 741 Query: 253 PAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRA----SDRERGQGEAPPQYLTDDLEFLR 308 PA+ ++ PL P+ P+P A S + +APP T L+ L Sbjct: 742 PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALP 801 Query: 309 ACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALD 368 + P S G AP + P A LP SP P A Sbjct: 802 S--PPASFPGQAP------------------FSPSASLPM---SPLATPPPQAPPVLAAP 838 Query: 369 TIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAA 428 + V P P + P +P P T + P +LA P Sbjct: 839 LLQVPPSPPASPTLQAPRR--------------PPTPGPD----TSVSGPRLTLALAPGP 880 Query: 429 QIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGE 488 P SS+ AG SA + E +L PEG Sbjct: 881 --PPPPSRSPSSTLSGPDLAGHSSSATSTPE--------------ELRGYDSGPEGGAAA 924 Query: 489 VPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPG 548 P P + H P PPL GAP PLP P+ PG Sbjct: 925 SPPPDAELAACH------PAAWSRGPAPPLAFR-------GAPGAPLPWPPATG----PG 967 Query: 549 PTDG-AKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRD 607 DG ++E EG S +PG + P P G G + A +S R Sbjct: 968 SADGLCTIYE--------TEGPESATPAPGALDPGPSP---GTSGGKAAAGAGAGASSRS 1016 Query: 608 PEVGK-DELSKPSSDAESRDH--------PSSHSAQPPRKGGAGHTDGPHSQTAEADASG 658 P+ + EL + A H ++ A GG G +G T A A+ Sbjct: 1017 PKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEG-GGVTGGARAAL 1075 Query: 659 LPHKLGEEDPVLPPVPDGAGEPT 681 +LG +L P+ + T Sbjct: 1076 SDAELGRWAELLSPLDESRASIT 1098 Score = 63.9 bits (154), Expect = 2e-09 Identities = 216/1019 (21%), Positives = 319/1019 (31%), Gaps = 131/1019 (12%) Query: 419 ASSLASFPAAQIP--IAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLG 476 A + A PAA+ P + PGS + PV+ A + + AG VG + G Sbjct: 10 AGAAARTPAARAPGLLTPRPPGSP------RPPPPVTPAALRVLGAAGAVGRKPLAERAG 63 Query: 477 SKGEH--PEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPP 534 G PE P P S + P PP + + P P Sbjct: 64 GIGGATIPESAPRAGPTRSAGTSSRN----------PASRPPASGRGERAPPAKNTSPGP 113 Query: 535 LPKAPSESARGPPGPTD--GAKVH-EDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDP 591 + S PGP G ++ E++ + A E + S G + + P G Sbjct: 114 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173 Query: 592 ----------GNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGA 641 G G A S++ P S S+ S PS + + P GG Sbjct: 174 PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 233 Query: 642 GHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPK--CPD 699 S ++ A P + G P P +P P+G L+P P Sbjct: 234 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK-PKGL----QALRPPQVTPP 288 Query: 700 TLQSREGLGRMESFLTLESEKSD-----FPP-----TPVAEVAPKAQEGESTLEIRKMGS 749 + LG + S S PP TP+ P + + L + Sbjct: 289 RKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSP 348 Query: 750 CDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCP 809 L T P P P A + PP + + + + + Q PS Sbjct: 349 SAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPP-IQVPHSLTSPSLQAPPSPL 407 Query: 810 GEGWIRGAAS--EWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSP-SHPGFK 866 ++ S L ++ L S Q + S+ + + PP++ +P S P Sbjct: 408 ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASP 467 Query: 867 DQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESS 926 S P+ + L H Q + + Q P +L P + + + S Sbjct: 468 PLQTSLSPAVSPLS----SPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSL 523 Query: 927 LTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCT 986 T + L+ P + LP+L + A + + P Sbjct: 524 QTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPA------------------ 565 Query: 987 GQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPC 1046 P Q + + + P + A PL GL ++ T PP Sbjct: 566 ---PCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLAT--PPPQ 620 Query: 1047 QPDSVAL--LDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWA 1104 P +AL L A P PA P SP TP+ AP A Q P P Q Sbjct: 621 APPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 680 Query: 1105 TSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQA-PEKPGEATLSCGLLQTE 1163 S SP A+ PS A + S A P A P L+ LQ Sbjct: 681 ASPPVSPS--ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP 738 Query: 1164 HCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELL 1223 + S SA P+ + +P +P S + A P P+ Sbjct: 739 PSPPASPPMSPSATPP--PRVPPLLAAPPLQVPPSPPASLPMSPL------AKPPPQ--- 787 Query: 1224 LSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAAS 1283 PP +A P L A+ G + S++ P +P +P P P LA Sbjct: 788 --APPALATPPLQALPSPPASFPG---QAPFSPSASLPMSPLATPPPQAPPVLA------ 836 Query: 1284 LKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATG 1343 APLLQ + P +QA P+ T GP S+ LA G Sbjct: 837 --------APLLQVPPSPPASPTLQA----PRRPPTPGPDTSVSGPRLTLALAPGPPPPP 884 Query: 1344 EEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATL 1402 ++ SG +AG ++ T E G S G GG S A L Sbjct: 885 SRSPSST------LSGPDLAGHSSSATSTPEELRGYDS-----GPEGGAAASPPPDAEL 932 Score = 63.9 bits (154), Expect = 2e-09 Identities = 141/621 (22%), Positives = 198/621 (31%), Gaps = 105/621 (16%) Query: 11 QRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDP 70 QR S SA P + + TP +P H S+ Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAH----------------PSQPKPKGLQ 278 Query: 71 CLVSPEVTEPRKDPQGARGP-EGSLLPSPPPSQEREHP-----SSSMPF-AECPPEGCLA 123 L P+VT PRKD A GP S L +P PS + P +++ P A PP LA Sbjct: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLA 338 Query: 124 SP-------AAAPEDGPQTQSPRREPAPNAPGDIAA---AFPAERDSSTPYQEIAAVPSA 173 +P +AP SP P AP + P + P Q ++ S Sbjct: 339 TPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP 398 Query: 174 GRERQPKE---EGQKSSFSFSSGIDQSP----GMSPVPLREPMKAPLCGEGDQPGGFESQ 226 + P +++ S S Q+ MSP + + +P P +S Sbjct: 399 SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPP---DSP 455 Query: 227 EKEAAGGFPPAESRQGVASVQVTP-EAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRA 285 +A P + Q S V+P +P S++ SP P++ + P Sbjct: 456 PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQ 515 Query: 286 SDRERGQGEAPPQYL-TDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHA 344 S + PP L T LE L + P + +AP PH Sbjct: 516 SSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP-----------------LTTPHL 558 Query: 345 ELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVS 404 E P P PA P +A + P+T P A P GLP Sbjct: 559 ETP---PCPAPCP------LQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSP 609 Query: 405 PEPSLLTPTEEAHPASSLASFPAAQ--------IPIAVEEPGSSSRESVSKAGMPVSADA 456 P L TP +A P +L A P+A P + + +V P S Sbjct: 610 PLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669 Query: 457 AKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPP 516 + V P P P+ +P + +V P P Sbjct: 670 SPPV----------------QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713 Query: 517 PLPKEQSHEVQPGAPP----PPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSP 572 P P S P APP PPL PS A P P + P +A + P Sbjct: 714 P-PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSP---SATPPPRVPPLLAAPPLQVP 769 Query: 573 GDSPGGKEEAP--EPPDGGDP 591 P +P +PP P Sbjct: 770 PSPPASLPMSPLAKPPPQAPP 790 Score = 60.5 bits (145), Expect = 2e-08 Identities = 193/883 (21%), Positives = 285/883 (32%), Gaps = 143/883 (16%) Query: 1197 ARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAV 1256 A GGI +T+ S +A P S P P A+ RG K Sbjct: 59 AERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPP---------ASGRGERAPPAKNT 109 Query: 1257 SSADPRAPGES-----PCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASS 1311 S +PG + P P+G+ L + ++ + AP +AG Sbjct: 110 SPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGAR-------- 161 Query: 1312 GSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAAT--APGAGAKASGEGMAGDAAGE 1369 R T GP P P +A+ +A G E AP A + EG + Sbjct: 162 -----RDTSGPTPGTPS----PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 212 Query: 1370 TEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGE 1429 +E S P+ + GG+ + + + + P L + A G Sbjct: 213 SEHSTTEPS-PAARRRPSAGGGLQRPASRSLSSSATP--------------LSSPARSGP 257 Query: 1430 KA-GAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLA 1488 A G R+ +P G + L PP V A PA L LA + A Sbjct: 258 SARGTPRAPAHPSQPKPKGLQALR--PPQVTPPRKDAAPA-LGPLSSSPLATPSPSGTKA 314 Query: 1489 LQDPASDKLLGPAGLTWERNLPGAG---VGKEMAGVPPTLREDERPEG------------ 1533 P D P T + P A + PP+L+ P Sbjct: 315 RPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTT 374 Query: 1534 -PGAAWPGLEGQAYSQLERSRQELA-SGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQ 1591 P A P L+ Q+ S + PSP A L + +H ++ Sbjct: 375 PPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSP 434 Query: 1592 DRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPW 1651 + + A P D P A +P P T SP L+ P Sbjct: 435 RQTQASLTSPSRPASTPP---DSPPLQAPLSLPASPPLQTSL-SPAVSPLSSPLTIHPLQ 490 Query: 1652 TLDTLGGERRPGVTAGI----LEMRNALGNQSTPAPPTGEVADTPLE--PGKVAGAAGEA 1705 L +L + + LE +++L S PP + PLE P A Sbjct: 491 ALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS-LTTPPLENLPSLAPPPLQTA 549 Query: 1706 EGDITLSTAETQACASG---DLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTA 1762 +T ET C + P + T + P PA + +P ++G Sbjct: 550 SAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALA--SPPLQGL- 606 Query: 1763 ALHGDSPARPQQAKEQPGPERP----IPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHT 1818 P+ P P P+ P +P + +PP P + P L Sbjct: 607 ------PSPPLSPLATPPPQAPPXLALPP------LQAPPSPPAS--PPL---------- 642 Query: 1819 DRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAA-PADLESP 1877 SP PS P P A ++ S SP A + P+A P P Sbjct: 643 ---SPLATPS--PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 697 Query: 1878 TLAASSYHGDVVGQVSTDLIAQSISP-------AAAHAGLPPSA-AEHIVSPSAPAGDRV 1929 +LAA S + + P AA +PPS A +SPSA RV Sbjct: 698 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV 757 Query: 1930 E---ASTPSC--PDPAKDLSRSSDSEEAFETPES--TTPVKAPPAPPPP--------PPE 1974 A+ P P P L S ++ + P + T P++A P+PP P Sbjct: 758 PPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 817 Query: 1975 VIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPS 2017 +P ++T PP P + + VP P + +P RPP+ Sbjct: 818 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860 Score = 56.6 bits (135), Expect = 4e-07 Identities = 239/1049 (22%), Positives = 341/1049 (32%), Gaps = 174/1049 (16%) Query: 414 EEAHPASSLASFPAAQIPIAVEEPGSSSRES----VSKAGMPVSADAAKEVVDAGLV--G 467 E A PA + + P V PG +S + + + G+ +SA+ E V G Sbjct: 101 ERAPPAKNTSPGP-------VSSPGRASGTTRPGPLGQKGLRISAE---ETVARGKATEA 150 Query: 468 LERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQ 527 +R G++ + PG P+P+ R TE +P P P + Sbjct: 151 PKRSALSAGARRDTSGPTPG-TPSPAMARRSRAAGTEVGLP-RPAPSARPRPPTEGPRKS 208 Query: 528 PGAPPPPLPKAPSESARGPPGPTDGAK--VHEDSTSPAVAKEGSRSPGDSPGGKEEAPEP 585 + PS +AR P G + +S A G S G AP Sbjct: 209 VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 268 Query: 586 PDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS--AQPPRKGGAGH 643 P P LQ + R P+V + P DA P S S A P G Sbjct: 269 PSQPKPKGLQ--------ALRPPQV-----TPPRKDAAPALGPLSSSPLATPSPSGTKAR 315 Query: 644 TDGPHSQTAEADASGLPHK--LGEEDPVLPPVPDGAGE-PTVPEGAIWEGSGLQP----- 695 P A + LP L P+ PP P T+P S P Sbjct: 316 PVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTP 375 Query: 696 --KCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEG------ESTLEIRKM 747 + P +LQ+ + S L S PP+P+A + +A ++T M Sbjct: 376 PMQAPPSLQTIPPIQVPHS---LTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTM 432 Query: 748 GSCDGEGLLTSPDQPRGPACDASRQEFHAGVP-HPPQGENLAADLG-LTALILDQDQQGI 805 + LTSP +P D+ + +P PP +L+ + L++ + Q + Sbjct: 433 SPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL 492 Query: 806 PSCPGEGWIRGAASE-WPLLSSEKHLQPSQAQ-PETSI----FDVLKEQAQPPENGKET- 858 S +S P L ++ L P Q P S+ + L A PP Sbjct: 493 SSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP 552 Query: 859 -------SPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQ-ALGSELQSQLPKGTL 910 +P P A S + P P+ +++ T Q AL S LP L Sbjct: 553 LTTPHLETPPCPAPCPLQAPPSPLTTP-PPETPSSIATPPPQAPPALASPPLQGLPSPPL 611 Query: 911 SDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLK 970 S T P AP LP L + SPPA+ L Sbjct: 612 SPLATPPP---------------QAPPXLALPPL-------------QAPPSPPASPPLS 643 Query: 971 DFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGL 1030 + + Q PN L A S + P + A+ SP Sbjct: 644 PLATP----------SPQAPNALAVHLLQA--PFSPPPSPPVQAPFSPPASPPVSP---- 687 Query: 1031 SKREMASGNTGEAPPCQ-PDSVAL--LDAVPCLPALAPASPGVTPTQDAPETEACDETQE 1087 PP Q P S+A L P PA P SP TP AP A Q Sbjct: 688 ----------SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQV 737 Query: 1088 GRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAP 1147 P P M AT P LLA+ P Q + A S A P QAP Sbjct: 738 PPSPPASPP---MSPSATPPPRVPPLLAAPPL---QVPPSPPASLPMSPLAKPP--PQAP 789 Query: 1148 EKPGEATLSCGLLQTEHCLTSGEE--ASTSALRESCQAEHPMASCQDALLPARELGGIPR 1205 P AT L + G+ + +++L S A P + P ++ P Sbjct: 790 --PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 847 Query: 1206 STMDFSTHQAVPDP-KELLLSGPPEVAA----PDTPYLHVDSAAQRGAEDSGVKAVSSAD 1260 ++ + P P + +SGP A P P S+ G + +G + +++ Sbjct: 848 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 907 Query: 1261 PRA-----PGESPCPVGEPPLALENAAS--LKLFAGSLAPLLQPGAAGGEIPAVQASSGS 1313 P G PP E AA G PL GA G +P A Sbjct: 908 PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA---- 963 Query: 1314 PKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGS 1373 T G D + + + G E A APGA G +G A G+ Sbjct: 964 ----TGPGSADGLCTI---------YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 1010 Query: 1374 MERMGEPSQDPKQGTSGGVDTSSEQIATL 1402 G S+ PKQ G + + Q + + Sbjct: 1011 ----GASSRSPKQARLGELPLGALQASVV 1035 Score = 54.3 bits (129), Expect = 2e-06 Identities = 90/364 (24%), Positives = 119/364 (32%), Gaps = 52/364 (14%) Query: 73 VSPEVTEPRKDPQGARGPEGSLLPSPPP----SQEREHPSSSMPFAECPPEGCLASPAAA 128 VSP T P + P P + PSPP S P + P PP SP A+ Sbjct: 685 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPAS 744 Query: 129 PEDGPQTQSPRREP----AP--NAPGDIAAAFPAERDSSTPYQ---EIAAVPSAGRERQP 179 P P P R P AP P A+ P + P Q +A P P Sbjct: 745 PPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPP 804 Query: 180 KEEGQKSSFSFSSGIDQSPGMSPVPLREP-MKAPLCGEGDQPGGFESQEKEAAGGFPPAE 238 ++ FS S+ + SP +P P P + APL P + + P + Sbjct: 805 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 864 Query: 239 S-----RQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQG 293 + R +A P P+ + T S L P++ S E G Sbjct: 865 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL-AGHSSSATSTPEELRGYDSGPEGGAA 923 Query: 294 EAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSP 353 +PP D E L ACH + G AP A P A LPW Sbjct: 924 ASPP----PDAE-LAACHPAAWSRGPAPPLAFRGA-------------PGAPLPW----- 960 Query: 354 ALVPEAGGSGKEALDTIDVQGHPQTGM-------RGTKPNQVVCVAAGGQPEGGLPVSPE 406 P G + L TI P++ G P AA G G SP+ Sbjct: 961 --PPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPK 1018 Query: 407 PSLL 410 + L Sbjct: 1019 QARL 1022 Score = 53.5 bits (127), Expect = 3e-06 Identities = 146/609 (23%), Positives = 197/609 (32%), Gaps = 119/609 (19%) Query: 124 SPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEG 183 S AA E G +P P P G + A S+T PS R+P G Sbjct: 180 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE-------PSPAARRRPSAGG 232 Query: 184 ---QKSSFSFSSGID--QSPGMSPVPLREPMKAPLCGEGDQPGGFES--------QEKEA 230 + +S S SS SP S R +AP +P G ++ K+A Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292 Query: 231 AGGFPPAESR-------QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMA-PIPQDPA 282 A P S G + V P AA T A L SP P+A P+P P Sbjct: 293 APALGPLSSSPLATPSPSGTKARPVPPPDNAA----TPLPATLPPSP--PLATPLPLAP- 345 Query: 283 PRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLP 342 P S APP T LP + +A + + P +P Sbjct: 346 PSPS--------APPSLQT----------LPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387 Query: 343 HAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP 402 ++P L SP+L +L G P ++ T L Sbjct: 388 PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT--LQAT--------------HSFLT 431 Query: 403 VSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRE-SVSKAGMPVSADAAKEVV 461 +SP + + T + PAS+ P Q P+++ P S + S+S A P+S+ + Sbjct: 432 MSPRQTQASLTSPSRPASTPPDSPPLQAPLSL--PASPPLQTSLSPAVSPLSSPLTIHPL 489 Query: 462 DA-GLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPL-- 518 A + + L S P + PS Q L T + P + PPPL Sbjct: 490 QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENL-PSLAPPPLQT 548 Query: 519 ---PKEQSHEVQPGAPPP------------PLPKAPSESARGPPGPTDGAKVHEDSTSPA 563 P H P P P P P+ PS A PP PA Sbjct: 549 ASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPP-----------QAPPA 597 Query: 564 VAK---EGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSS 620 +A +G SP SP PP P LQ S S P L+ PS Sbjct: 598 LASPPLQGLPSPPLSPLATPPPQAPPXLALP-PLQAPPSPPASPPLSP------LATPSP 650 Query: 621 DAESR------DHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVP 674 A + P S PP + P + S P L +PP P Sbjct: 651 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 710 Query: 675 DGAGEPTVP 683 A P P Sbjct: 711 P-ASPPMSP 718 Score = 42.4 bits (98), Expect = 0.007 Identities = 118/538 (21%), Positives = 170/538 (31%), Gaps = 107/538 (19%) Query: 131 DGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIA-----AVPSAGRERQPKEEGQK 185 D + + R PA APG + P P A A + GR+ + G Sbjct: 6 DKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGI 65 Query: 186 SSFSFS-----SGIDQSPGMSPVPLREPM-KAPLCGEGDQ--------PGGFESQEKEAA 231 + +G +S G S R P + P G G++ PG S + + Sbjct: 66 GGATIPESAPRAGPTRSAGTSS---RNPASRPPASGRGERAPPAKNTSPGPVSSPGRASG 122 Query: 232 GGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERG 291 P ++G+ A A + + SA+ + P P P+P + R R Sbjct: 123 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182 Query: 292 QGEAPPQYLTDDLEFLRACHLPRSNSGA-------APEAEVNAASQESCQQPVGAYLPHA 344 G LPR A P V++AS+ S +P A Sbjct: 183 AG--------------TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP 228 Query: 345 ELPWGLPSPA---LVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGL 401 GL PA L A A +G P+ ++P +P+G Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP----------KPKGLQ 278 Query: 402 PVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVV 461 + P P + P ++A PA P + P+A P S +KA D A + Sbjct: 279 ALRP-PQVTPPRKDAAPALG----PLSSSPLATPSP------SGTKARPVPPPDNAATPL 327 Query: 462 DAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKE 521 A L + L P P PSP P PP P Sbjct: 328 PATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP----------------PATPPSQAP-- 369 Query: 522 QSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEE 581 P PP+ PS P +V TSP++ ++P SP Sbjct: 370 ------PSMTTPPMQAPPSLQTIPP------IQVPHSLTSPSL-----QAP-PSPLALSS 411 Query: 582 APEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSS---DAESRDHPSSHSAQPP 636 G P LQ S S R + S+P+S D+ P S A PP Sbjct: 412 LQATTSLGSP-TLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPP 468 >gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens] Length = 1466 Score = 89.7 bits (221), Expect = 4e-17 Identities = 282/1229 (22%), Positives = 364/1229 (29%), Gaps = 207/1229 (16%) Query: 17 QTPRSAQPPGNSQNIKRKQQDT--PGSPDHRDASSI-------GSVGLGGFCTASESSAS 67 Q P + P N Q + + D PG P I GS G G C Sbjct: 90 QPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGIC-------- 141 Query: 68 LDPCLVSPEVTEPRKDPQ------------GARGPEGSLLPSPPPSQEREHPSSSMPFAE 115 + C P+ P+ D G GP G P PP S P + Sbjct: 142 -ESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQ 200 Query: 116 CPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGR 175 PP P A GP P PG I + PA +D + GR Sbjct: 201 GPP----GEPGQAGPSGP----------PGPPGAIGPSGPAGKDGES-----------GR 235 Query: 176 ERQPKEEGQKS--SFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGG 233 +P E G +GI PGM + GE PG G Sbjct: 236 PGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEK-GETGAPGLKGENGLPGENG 294 Query: 234 FPPAESRQGVASVQVTPEAPAAA-QQGTESSAVLEKSPLKPMAP----IPQDPA------ 282 P +G + P P AA +G + + + P P P P P Sbjct: 295 APGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVG 354 Query: 283 PRASDRERG----QGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVG 338 P S G +GE PQ P N + E+ A +G Sbjct: 355 PAGSPGSNGAPGQRGEPGPQ---GHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMG 411 Query: 339 AYLPHAELPWGLP-SPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQP 397 A P P G +P L AG GK +G P G RG + + G + Sbjct: 412 ARGPPG--PAGANGAPGLRGGAGEPGKNG-----AKGEP--GPRGERGEAGIPGVPGAKG 462 Query: 398 EGGLPVSP----------------EPSLLTPTE------EAHPASSLASFPAAQIPIAVE 435 E G SP P P E PA + A A Sbjct: 463 EDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAG 522 Query: 436 EPGSSSRESV----SKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH-PEGDPGEVP 490 EPG R+ V GMP S G G + + G G P G PG + Sbjct: 523 EPG---RDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMG 579 Query: 491 APSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPT 550 P P+ + + PG P P P ++ E P PP P + GPPGP Sbjct: 580 FPGPKGN-DGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQ 638 Query: 551 -------DGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFS 603 G E+ +G +PGGK +A P + G PG + + Sbjct: 639 GLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGA 698 Query: 604 SKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAE---ADASGLP 660 PE GK P + P +GG G + GP E A G+P Sbjct: 699 GPPGPEGGKGAAGPPGPPGAA--GTPGLQGMPGERGGLG-SPGPKGDKGEPGGPGADGVP 755 Query: 661 HKLGEEDPVLPPVPDG-AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESE 719 K G P P P G AG+P +G G P P R G Sbjct: 756 GKDGPRGPTGPIGPPGPAGQPGD------KGEGGAPGLPGIAGPRGSPG---------ER 800 Query: 720 KSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQ--PRGPACDASRQEFHAG 777 PP P Q GE G+G +P + GP G Sbjct: 801 GETGPPGPAGFPGAPGQNGEP----------GGKGERGAPGEKGEGGP----------PG 840 Query: 778 VPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQP 837 V PP G A G + + ++G P PG GA S + P P Sbjct: 841 VAGPPGGSGPAGPPGPQGV---KGERGSPGGPGAAGFPGARGLPGPPGSNGN--PGPPGP 895 Query: 838 ETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEP--QEDNNLPTHGGQEQ 895 S + P G +P PG D+ Q P Q P G Sbjct: 896 SGS----PGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAG 951 Query: 896 ALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSA----PTRQKLPALGEKRPEG 951 G+ + P G + P + ES + LS P Q LP L Sbjct: 952 ITGARGLAG-PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGL------- 1003 Query: 952 ACGDGQSSRVSPPAADVL--KDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEE 1009 A G+ R P +D L +D S G R E G + + + Sbjct: 1004 AGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGD 1063 Query: 1010 ACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPG 1069 + P A G + G + G+ GE + P P AP SPG Sbjct: 1064 RGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPG-APGSPG 1122 Query: 1070 VTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGA 1129 Q A + G + PV P TS P G G Sbjct: 1123 PAGQQGAIGSPG----PAGPRGPV-GPSGPPGKDGTSGHPGP--------IGPPGPRGNR 1169 Query: 1130 AETGGSAGAGDPGKQQAPEKPGEATLSCG 1158 E G G PG+ P PG CG Sbjct: 1170 GERGSEGSPGHPGQPGPPGPPGAPGPCCG 1198 Score = 55.1 bits (131), Expect = 1e-06 Identities = 245/1034 (23%), Positives = 308/1034 (29%), Gaps = 244/1034 (23%) Query: 1114 LASFPSAGEQGGEAGAAETGGSAGA-GDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEA 1172 LA +P G G T G G+ G PG Q P +PG+A SG Sbjct: 169 LAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAG------------PSGPPG 216 Query: 1173 STSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAA 1232 A+ S P ++ P R P E L GPP + Sbjct: 217 PPGAIGPS----GPAGKDGESGRPGR--------------------PGERGLPGPPGIKG 252 Query: 1233 PDTPYLHVDSAAQRGAED-SGVKAVSSAD----------------PRAPGESPCPVGEPP 1275 P RG + +G K + A P P +P G P Sbjct: 253 PAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRP- 311 Query: 1276 LALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMP-- 1333 L AA + G+ QPG G P GSP A+ GP S P + P Sbjct: 312 -GLPGAAGARGNDGARGSDGQPGPPGP--PGTAGFPGSPGAKGEVGPAGS-PGSNGAPGQ 367 Query: 1334 ---------LLAKGKQAT----------GEEKAATAPGAGAKASGEGMAGDA-AGETEGS 1373 A+G GE A PGA G G A A G Sbjct: 368 RGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGL 427 Query: 1374 MERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGA 1433 GEP ++ +G G E A + G P + K GA PG A Sbjct: 428 RGGAGEPGKNGAKGEPGPRGERGE--AGIPGVPGAKGEDGKDGSPGEPGANGLPG--AAG 483 Query: 1434 GRSAVGKDLTRPLGPEKLLD--GPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQD 1491 R A G P GP + GP G PA P + AGE Sbjct: 484 ERGAPG--FRGPAGPNGIPGEKGPAGERGAPGPAGP--------RGAAGE---------- 523 Query: 1492 PASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLER 1551 P D + G G+ PG G P + E RP PG + P Sbjct: 524 PGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGP------------ 571 Query: 1552 SRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHG 1611 Q G P P P + + P G + P GK + + P G Sbjct: 572 RGQPGVMGFPGPKGNDGAPGKNGE--RGGPGGPGPQG------PPGKNGE--TGPQGPPG 621 Query: 1612 EDGP-GDFAHTGVPG-----HVPRSTCAPSPQREVLTVPEANSEPWTLDTLG-------- 1657 GP GD TG PG +P T P + P + G Sbjct: 622 PTGPGGDKGDTGPPGPQGLQGLP-GTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAP 680 Query: 1658 GERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQ 1717 GER P AG +R G P P G+ A P P AG G +G Sbjct: 681 GERGPPGLAGAPGLR---GGAGPPGPEGGKGAAGPPGPPGAAGTPG-LQGMPGERGGLGS 736 Query: 1718 ACASGDLPEAGTTRTFSV--------VAGDLVLPGSCQDPACSDK--APGMEGTAALHGD 1767 GD E G V G + PG P + APG+ G A G Sbjct: 737 PGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGS 796 Query: 1768 S--------------PARPQQAKEQPGP-ERPIPAGDGK---VCVSSPPEPDETHDPKLQ 1809 P P Q E G ER P G+ V+ PP P Sbjct: 797 PGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPP-- 854 Query: 1810 HLAPEELHTDRESPR-------PGPSMLPSVPKKDA----PRVMDKVTSDETRGAEGTES 1858 P+ + +R SP PG LP P + P D G G Sbjct: 855 --GPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTG 912 Query: 1859 SPVADDIIQP----AAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSA 1914 +P + + P P + SP +G I+ A AG PP Sbjct: 913 APGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLG-------IAGITGARGLAG-PPGM 964 Query: 1915 AEHIVSPSAPAGDRVEASTP----------------------SCPDPAKDLSRSSDSEEA 1952 SP P G + E+ P + +P +D + SD Sbjct: 965 PGPRGSP-GPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPG 1023 Query: 1953 --------FETPESTTPVKAPPAP--PPPPPEVIP------EPEVSTQPPPEEPG-CGSE 1995 + E+ +P AP AP P PP V P E P PG GS Sbjct: 1024 RDGSPGGKGDRGENGSP-GAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSR 1082 Query: 1996 TVPVPDGPRSDSVE 2009 P P GPR D E Sbjct: 1083 GAPGPQGPRGDKGE 1096 Score = 38.1 bits (87), Expect = 0.13 Identities = 41/173 (23%), Positives = 57/173 (32%), Gaps = 20/173 (11%) Query: 514 PPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAV-AKEGSRSP 572 P P +P + V P P P + +GP G + + P + + GS Sbjct: 75 PNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGS 134 Query: 573 GDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS 632 PG E P P P ++ K VG P+ Sbjct: 135 PGPPGICESCPTGPQNYSP------QYDSYDVKSGVAVG---------GLAGYPGPAGPP 179 Query: 633 AQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEG 685 P G +GH P S + G P + G+ P PP P GA P+ P G Sbjct: 180 GPPGPPGTSGHPGSPGSPGYQ----GPPGEPGQAGPSGPPGPPGAIGPSGPAG 228 >gi|189181724 proteoglycan 4 isoform D [Homo sapiens] Length = 1270 Score = 89.0 bits (219), Expect = 6e-17 Identities = 192/885 (21%), Positives = 301/885 (34%), Gaps = 93/885 (10%) Query: 1771 RPQQAKEQPGPERPI--PAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPS 1828 + + K++P P+ P+ AG G +T + ++ T + P PS Sbjct: 70 KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 129 Query: 1829 MLP-SVPKKDAPRVMDKVTSDETR---------GAEGTESSPVADDI--IQPAAPADLE- 1875 + P S K+ ++K T+ ET+ +G E + A + I+ + DL Sbjct: 130 LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 189 Query: 1876 -SPTLAASSYHGDVVGQVSTDLIAQSISPAAAH--AGLPPSAAEHIVSPSAPAGDRVEA- 1931 S LA + + + + +P A P SAP + A Sbjct: 190 TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 249 Query: 1932 -STPSCPDPAKDLSRSSDSEEAFETPESTTPV----------KAPPAPPPPPPEVIPEPE 1980 +T S P K+ + ++ E A TP+ P K+ P P P P+ Sbjct: 250 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 309 Query: 1981 VSTQPPPEEPGCGSETVPV-PDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLD 2039 T P P E P P P + E +P P + +A KP ++ Sbjct: 310 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA---PKKPAPTTPKEPAP 366 Query: 2040 FDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASS 2099 E T T EP + K +T P +T S + + ++ Sbjct: 367 TTPKEPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS---PTT 422 Query: 2100 SGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDE 2159 + P A +T A +T K P P TTKKP T P + P E Sbjct: 423 TKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKPAPTTPKEPAPTTPKE 481 Query: 2160 ------ESLVPSG-ENLASETKTESAKT--EGPSPALLEE----TPLEPA-VGPKAACPL 2205 + L P+ E LA T + A T E +P EE TP EPA PKAA P Sbjct: 482 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 541 Query: 2206 DSESAEGVVP----PASGGGRVQNSPPVGRKTLPLTTAP----EAGEVTPSDSGGQEDSP 2257 + P P + +P T P TAP E TP +E +P Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 601 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS 2317 + + + DK + + P T K K P P L + Sbjct: 602 T---TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 658 Query: 2318 PPRSPAEPNDIPIA-KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDE 2376 P+ PA P KG + DK + T+ + +P P++ P+T Sbjct: 659 TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 718 Query: 2377 SVDPFKT--SSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPA-KKKKTPLKTDTFRV 2433 + T ++K P++ KSP SA + +P KTP T Sbjct: 719 TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 778 Query: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKL-AVTNQKWTCMTVDLEADK 2492 + ++ D + T A P+ + T E K+ A T Q + T D K Sbjct: 779 TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 838 Query: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552 + + L+ V TK + T E+ M K P++ PK +A + Sbjct: 839 ITTLKTTTLAPKVTTTKKTITTTEI----------MNK-----PEETAKPKDRAT----N 879 Query: 2553 TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 2597 + +P P + + PT S ++ + + P PR Sbjct: 880 SKATTPKPQKPTKAPKKPT-----STKKPKTMPRVRKPKTTPTPR 919 Score = 77.8 bits (190), Expect = 1e-13 Identities = 155/732 (21%), Positives = 241/732 (32%), Gaps = 70/732 (9%) Query: 1628 PRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE 1687 P +T P+P P EP T P A + A PAP T + Sbjct: 264 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 323 Query: 1688 VADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQ 1747 TP P + A E +T + A + P T + + P + + Sbjct: 324 -EPTPTTPKEPAPTTKEPAP----TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378 Query: 1748 DPACS---DKAPGMEGTAALHGDSPARPQQAKEQPG-PERPIPAGDGKVCVSSPPEPDET 1803 +P+ + + AP +A PA P K P P+ P P + ++P EP T Sbjct: 379 EPSPTTPKEPAPTTTKSAPTTTKEPA-PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 437 Query: 1804 HDPKLQHLAPEE-LHTDRESPRPGPSM--LPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 K P+E T + P P + P+ PK+ AP T ET + +P Sbjct: 438 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP-----TTPKETAPTTPKKLTP 492 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-V 1919 + + P P E P + T + +P A P + E Sbjct: 493 TTPEKLAPTTP---EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 549 Query: 1920 SPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEP 1979 +P PA + P+ P + + + P TTP K PAP P EP Sbjct: 550 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP 607 Query: 1980 EVST--QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYN 2037 +T +P P P + T P P + E +P P + E P Sbjct: 608 TSTTCDKPAPTTPKGTAPTTPKEPAPTTPK-EPAP-TTPKGTAPTTLKEPAPTTPKKPAP 665 Query: 2038 LDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDG 2096 + T + + +E T ++ + P + T + S+ Sbjct: 666 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 725 Query: 2097 ASSSGNPEAVALAPDAYSTGSSSASSTLKRTK-KPRPPSLKKKQTTKKPTETPPVKETQQ 2155 +++ P + +PD ST SA T K + P+ P + TTK P T P T Sbjct: 726 PTTTKEPTTIHKSPDE-STPELSAEPTPKALENSPKEPGV---PTTKTPAATKPEMTTTA 781 Query: 2156 EPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP 2215 ++ ET T + K + E+T +ES Sbjct: 782 ---KDKTTERDLRTTPETTTAAPKMTKETATTTEKT---------------TESKITATT 823 Query: 2216 PASGGGRVQNSPPVGRKTLPLTT-APEA----GEVTPSDSGGQEDSPAKGLSVRLEFDYS 2270 Q++ P TL TT AP+ +T ++ + + AK + Sbjct: 824 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 883 Query: 2271 EDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNT-PASPPRS-------- 2321 K + P + KKP +R+PK TP K+ +T P P S Sbjct: 884 TPKPQKPTKAPKKPTST---KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 940 Query: 2322 -PAEPNDIPIAK 2332 PN P +K Sbjct: 941 TTTRPNQTPNSK 952 Score = 77.0 bits (188), Expect = 3e-13 Identities = 130/630 (20%), Positives = 201/630 (31%), Gaps = 65/630 (10%) Query: 19 PRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVT 78 P S P + + TP P S + T ++ A P +P T Sbjct: 224 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT 283 Query: 79 EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSP 138 K+P P P + P+ + P P +P E P T+ P Sbjct: 284 ---KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 340 Query: 139 R----REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGI 194 +EPAP AP A P E +TP + P+ +E P + + + S Sbjct: 341 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAP 397 Query: 195 DQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPA 254 + +P + P +P ++E PA + TP+ PA Sbjct: 398 TTTKEPAPTTTKSAPTTP-----KEPSPTTTKEPAPTTPKEPAPTTP-KKPAPTTPKEPA 451 Query: 255 AAQQGTESSAVLEK-SPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLP 313 + +K +P P P P P A + P+ L A P Sbjct: 452 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 511 Query: 314 RSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPE-AGGSGKEALDTIDV 372 + PE +E A P+ P+P E A + KE T Sbjct: 512 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTPKEPAPTTPKEPAPTTPK 568 Query: 373 QGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPI 432 + P T +GT P + +P P P P L PT P S+ PA P Sbjct: 569 ETAPTT-PKGTAPTTL------KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 620 Query: 433 AVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHP----EGDPGE 488 + + K P + ++ + KG P E P Sbjct: 621 ------KGTAPTTPKEPAPTT---------------PKEPAPTTPKGTAPTTLKEPAPTT 659 Query: 489 VPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPG 548 P+P+E T+ P P PKE + P P P PK P+ + P Sbjct: 660 PKKPAPKELAP-TTTKGPTSTTSDKPAPTTPKETA-PTTPKEPAPTTPKKPAPTTPETPP 717 Query: 549 PTDGAKVHEDSTSPAVAKEGS---RSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PT + ++P KE + +SP +S P P + G + + Sbjct: 718 PTT-----SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 772 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQP 635 PE+ K +++ + R P + +A P Sbjct: 773 TKPEMTTTAKDK-TTERDLRTTPETTTAAP 801 Score = 74.7 bits (182), Expect = 1e-12 Identities = 160/747 (21%), Positives = 249/747 (33%), Gaps = 94/747 (12%) Query: 1781 PERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP-----RPGPSML----P 1831 P+ P P + ++P EP T E T +S P P+ P Sbjct: 213 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 272 Query: 1832 SVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA-------APADLESPTLAASSY 1884 + PK+ AP + T+ A T P +PA AP + PT Sbjct: 273 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE 332 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-VSPSAPAGDRVEASTPSCP-DPAKD 1942 + + + +P A P + E +P PA + +P+ P +PA Sbjct: 333 PAPTTKEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 391 Query: 1943 LSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVST--QPPPEEPGCGSETVP-- 1998 ++S+ + + P TT AP P P P EP +T +P P P + T P Sbjct: 392 TTKSAPTTT--KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 449 Query: 1999 -VPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 2057 P P+ + + P+ K A + L E + T + + Sbjct: 450 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPA 507 Query: 2058 DAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTG 2116 +E T + T + P + T ++ + ++ P A +T Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 567 Query: 2117 SSSASSTLKRT-----KKPRPPSLKKKQ-------TTKKPTETPPVKETQQEPDEESLVP 2164 +A +T K T K+P P + KK TTK+PT T K P + Sbjct: 568 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 627 Query: 2165 SGENLASETKTESAKT-EGPSPALLEE----TPLEPAVGPKAACPLDSESAEGVVP---- 2215 E + K + T +G +P L+E TP +PA PK P ++ Sbjct: 628 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA--PKELAPTTTKGPTSTTSDKPA 685 Query: 2216 PASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSS 2275 P + +P T P AP E P + E S S D+S+ Sbjct: 686 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS--EVSTPTTTKEPTTIHKSPDEST 743 Query: 2276 WDNQQENPPPTKKIGKK----PVAKMPLR-RPKM------KKTPEKLDNTPASPPRSPAE 2324 + E P + K P K P +P+M K T L TP + +P Sbjct: 744 PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK- 802 Query: 2325 PNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS 2384 + K T T T++ + + Q + DT + KT+ Sbjct: 803 -----MTKETATTT------------EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 845 Query: 2385 SKTP--SSPSKSPASFEIPASAMEANGVDGDGLN------KPAKKKKTPLKTDTFRVKKS 2436 + P ++ K+ + EI E N KP K K P K + K Sbjct: 846 TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS---TKK 902 Query: 2437 PKRSPLSDPPSQDPTPAATPETPPVIS 2463 PK P P PTP T P ++ Sbjct: 903 PKTMPRVRKPKTTPTPRKMTSTMPELN 929 Score = 68.9 bits (167), Expect = 7e-11 Identities = 174/870 (20%), Positives = 267/870 (30%), Gaps = 117/870 (13%) Query: 1365 DAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEK---PVL 1421 D + ET ++ + E + + K+ T+ TS++ T + + I K K P Sbjct: 135 DTSKETSLTVNK--ETTVETKETTTTNKQTSTDGKEKTTSAKE-TQSIEKTSAKDLAPTS 191 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPA--RLQVEKKQQLA 1479 LA P KA + G LT P P P P P K+ Sbjct: 192 KVLAKPTPKAET--TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 249 Query: 1480 GEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVP----PTLREDERPEGPG 1535 + + ++PA PA T + P KE A PT ++ P P Sbjct: 250 TTTKSAPTTPKEPAPTTTKEPAPTTPKE--PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 307 Query: 1536 AAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVER-----AAAFQVAPHSHGEEAVA 1590 P + + P+P + P A + AP + E A Sbjct: 308 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 367 Query: 1591 QDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRST-CAPSPQREVLTVPEANSE 1649 + P+ +E S A T P +T AP+ +E P E Sbjct: 368 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE--PSPTTTKE 425 Query: 1650 PW-TLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE--VADTPLEPGKVAG--AAGE 1704 P T P A A PAP T + TP EP A Sbjct: 426 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 485 Query: 1705 AEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAAL 1764 +T +T E A + + P T + + P + ++PA Sbjct: 486 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA-------------- 531 Query: 1765 HGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPR 1824 P P+ A P+ P P + ++P EP T + P+ +P Sbjct: 532 ----PTTPKAAAPNT-PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT-----APT 581 Query: 1825 PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSY 1884 P+ PKK AP+ + T+ E + +P P P + +PT Sbjct: 582 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE-PAPTTPKEPA 640 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLS 1944 G T L PA P A ++P+ G S P K+ + Sbjct: 641 PTTPKGTAPTTLK----EPAPT---TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 693 Query: 1945 RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPR 2004 ++ E A TP+ P P PPP + P + +P T + P Sbjct: 694 PTTPKEPAPTTPKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 751 Query: 2005 SDSVEGSPFRP---PSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTF---QTLEPRASD 2058 ++E SP P + + +A E A T D T T E + Sbjct: 752 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTT 811 Query: 2059 AKNQEGKVN------TRRKSTDSVP-----ISKSTLSRSLSLQASDFDGASSSGNPEAVA 2107 K E K+ T + D+ P + +TL+ ++ PE A Sbjct: 812 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETA 871 Query: 2108 LAPDAYSTGSSSASSTLKRTKKPRPPSLKKK----------------------------- 2138 D + ++ K TK P+ P+ KK Sbjct: 872 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 931 Query: 2139 --------QTTKKPTETPPVKETQQEPDEE 2160 QTT +P +TP K + P E Sbjct: 932 SRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 961 Score = 68.2 bits (165), Expect = 1e-10 Identities = 126/605 (20%), Positives = 192/605 (31%), Gaps = 101/605 (16%) Query: 2031 ASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPIS-------KSTL 2083 A SG N DF + DT T Q KV+T K T + PI+ S Sbjct: 88 AGSGLDNGDF-KVTTPDTSTT----------QHNKVSTSPKITTAKPINPRPSLPPNSDT 136 Query: 2084 SRSLSL-----------QASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRP 2132 S+ SL + + + +S+ E A + S +SA +K Sbjct: 137 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 196 Query: 2133 PSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETP 2192 P+ K + TTK P T P + T P E + E + K+ + P+P + P Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 256 Query: 2193 LEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVT---PSD 2249 PK P ++ P + P K+ P TT E T P+ Sbjct: 257 ----TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP-TTPKEPAPTTPKKPAP 311 Query: 2250 SGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPE 2309 + +E +P + K + P PT K K P K P Sbjct: 312 TTPKEPAP------------TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP- 358 Query: 2310 KLDNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYN 2368 TP P P +P EP P ++ +PK P + Sbjct: 359 ---TTPKEPAPTTPKEP----------------------APTTTKEPSPTTPKEPAPTTT 393 Query: 2369 FDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKT 2428 T + P T S + SP + + PA K P T Sbjct: 394 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 453 Query: 2429 DTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTV-- 2486 + + P P ++P P ET P + T EKLA T + T Sbjct: 454 TPKEPAPTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 512 Query: 2487 DLEADKQDYPQPSDLSTFVNET-KFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPK 2543 +L + P P+ T K ++P ++ + P++ PK Sbjct: 513 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP------------KEPAPTTPKEPAPTTPK 560 Query: 2544 KQALYLMFDTSQESPVKSSPVRMSE-------SPTPCSGSSFEETEALVNTAAKNQHPVP 2596 + A +T+ +P ++P + E P P + E T K P Sbjct: 561 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 620 Query: 2597 RGLAP 2601 +G AP Sbjct: 621 KGTAP 625 Score = 57.0 bits (136), Expect = 3e-07 Identities = 106/514 (20%), Positives = 169/514 (32%), Gaps = 67/514 (13%) Query: 2136 KKKQTTKKPTETPPVKETQQEPDEESLVPSGENLAS--ETKTESAKTEGPSPALLEETPL 2193 KK +T KKPT PPV + + S + +G+ + +T T SP + P Sbjct: 70 KKNRTKKKPTPKPPVVD-----EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKP- 123 Query: 2194 EPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQ 2253 + P+ + P +S++++ + S V ++ T E E T ++ Sbjct: 124 ---INPRPSLPPNSDTSK------------ETSLTVNKE-----TTVETKETTTTNKQTS 163 Query: 2254 EDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPV--AKMPLRRPKMKKTPEKL 2311 D K S + E +S ++ PT K+ KP A+ + P + E Sbjct: 164 TDGKEKTTSAK------ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 217 Query: 2312 DNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFD 2370 TP P +P EP I T P ++T +PK P + + Sbjct: 218 PTTPKEPASTTPKEPTPTTIKSAPTT--------PKEPAPTTTKSAPTTPKEPAPTTTKE 269 Query: 2371 P-DTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTD 2429 P T + P T P++ +P + + PA P + T K Sbjct: 270 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAP----TTPKEPAPTTPKEP 325 Query: 2430 TFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE 2489 T K P P +++P P E P T ++ A T K T E Sbjct: 326 TPTTPKEPA------PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 379 Query: 2490 AD--KQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQAL 2547 P P+ + TK +PT + + P P Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 439 Query: 2548 YLMFDTSQESPVKSSPVRMSESPTPCSGSSFEET---EALVNTAAKNQHPVPRGLAPNQE 2604 T+ + P ++P + P P + T E T + P+ L P Sbjct: 440 KKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP 495 Query: 2605 SHL--QVPEKSSQKELEAMGLGTPSEAIEITAPE 2636 L PEK + E + TP E T E Sbjct: 496 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 529 Score = 53.1 bits (126), Expect = 4e-06 Identities = 122/631 (19%), Positives = 194/631 (30%), Gaps = 82/631 (12%) Query: 137 SPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAV----PSAGRERQPKEEGQKSSFSFSS 192 +PR PN+ + ++++ +E + G+E+ + + S +S Sbjct: 125 NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAK-ETQSIEKTS 183 Query: 193 GIDQSPGMS----PVPLREPM-KAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQ 247 D +P P P E K P +P + KE A P + + S Sbjct: 184 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAP 241 Query: 248 VTPEAPAAAQQGTESSAVLEKSPL-----KPMAPIPQDPAPRASDRERGQGEAPPQYLTD 302 TP+ PA T+S+ K P +P P++PAP + Sbjct: 242 TTPKEPAPTT--TKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP------------- 286 Query: 303 DLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGS 362 P + A + A + P P P P+P E + Sbjct: 287 ---------APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPTPTTPKEPAPT 336 Query: 363 GKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSL 422 KE T + P T P + A P+ P +P+ T T+E P + Sbjct: 337 TKEPAPTTPKEPAP------TAPKK----PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPK 386 Query: 423 ASFPAA--QIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE 480 P P +EP ++ +S S KE + + Sbjct: 387 EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT------TPKEPAPTTPK 440 Query: 481 HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQS------------HEVQP 528 P + PAP+ + T++ P P P PKE + ++ P Sbjct: 441 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP 500 Query: 529 GAPPPPLPKAPSESA-RGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPD 587 P P P P E A P PT T+P A + KE AP P Sbjct: 501 TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK 560 Query: 588 GGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGP 647 +P +++ + K L +P+ + P + ++ + D P Sbjct: 561 --EPAPTTPKETAPTTPK---GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615 Query: 648 HSQTAEADASGLPHKLGEEDP--VLPPVPDGAGEPTVPEGAIWEGSGLQPK--CPDTLQS 703 T + A P + P P P G T+ E A PK P T + Sbjct: 616 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 675 Query: 704 REGLGRMESFLTLESEKSDFPPTPVAEVAPK 734 + T E + P A PK Sbjct: 676 PTSTTSDKPAPTTPKETAPTTPKEPAPTTPK 706 Score = 48.5 bits (114), Expect = 1e-04 Identities = 132/700 (18%), Positives = 207/700 (29%), Gaps = 153/700 (21%) Query: 266 LEKSPLKPMAPIPQ---DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPE 322 +EK+ K +AP + P P+A +G P+ T P+ + P+ Sbjct: 179 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT--------PKEPASTTPK 230 Query: 323 AEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRG 382 +P + A P+P A + KE T + P T Sbjct: 231 ------------EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 278 Query: 383 T-----KPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 +P +A P+ P +P+ T +E P + P P +EP Sbjct: 279 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-----PKEPTPTTPKEP 333 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQER 497 +++E P + PAP+ ++ Sbjct: 334 APTTKE--------------------------------------PAPTTPKEPAPTAPKK 355 Query: 498 GEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHE 557 ++ P P P KE S P AP+ + P T A Sbjct: 356 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 415 Query: 558 DSTSPAVAKE-GSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELS 616 SP KE +P + + P P +P ++ ++K+ E + Sbjct: 416 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 475 Query: 617 KPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDG 676 + + P + P K + P T E A P E P P P Sbjct: 476 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE---EPTPTTPEEP-- 530 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQ 736 PT P+ A P+T + E T E + PT E AP Sbjct: 531 --APTTPKAA----------APNTPKEPAPTTPKEPAPTTPKEPA---PTTPKETAPTTP 575 Query: 737 EGESTLEIRKMG------SCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAAD 790 +G + +++ E T+ +P CD P P+G Sbjct: 576 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-------APTTPKGT----- 623 Query: 791 LGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQ 850 P+ P E P ++ K +P+ P+ + LKE A Sbjct: 624 --------------APTTPKE----------PAPTTPK--EPAPTTPKGTAPTTLKEPA- 656 Query: 851 PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTL 910 T+P P K+ +++ P D PT E PK Sbjct: 657 ------PTTPKKPAPKELAPTTTK--GPTSTTSDKPAPT-------TPKETAPTTPKEPA 701 Query: 911 SDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPE 950 TP P E+ SE+S PT K P K P+ Sbjct: 702 PTTP-KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 740 Score = 37.4 bits (85), Expect = 0.22 Identities = 84/379 (22%), Positives = 116/379 (30%), Gaps = 42/379 (11%) Query: 1040 TGEAPPCQPDSVALLDAVPCLPA-LAPASPG-VTPTQDAPETEACDETQEGRQQPVPAPQ 1097 T E P P A P PA P P TP + AP T ++ PAP Sbjct: 337 TKEPAPTTPKEPA--PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPT 391 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQGGEAGAAE---TGGSAGAGDPGKQQAPEKPGEAT 1154 T+ +P S P+ ++ E T A K+ AP P E Sbjct: 392 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 451 Query: 1155 LSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQ 1214 + T E A T+ + + P P+ T + + Sbjct: 452 PT----------TPKEPAPTTTKKPA------------PTTPKEPAPTTPKETAPTTPKK 489 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGA----EDSGVKAVSSADPRAPGESPCP 1270 P E L PE AP TP + + E+ +A P P E Sbjct: 490 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 549 Query: 1271 VGEPPLALENAASLKLFAGSLAPLLQPGAAGGEI--PA-VQASSGSPK--ARTTEGPVDS 1325 + P AP G A + PA +PK A TT S Sbjct: 550 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 609 Query: 1326 MPCLDRMPLLAKGKQ-ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 C P KG T +E A T P A + +G A E + + P + Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 669 Query: 1385 KQGTSGGVDTSSEQIATLT 1403 T G T+S++ A T Sbjct: 670 PTTTKGPTSTTSDKPAPTT 688 Score = 32.0 bits (71), Expect = 9.3 Identities = 105/542 (19%), Positives = 166/542 (30%), Gaps = 43/542 (7%) Query: 831 QPSQAQPETSIFDVLKEQAQ--PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLP 888 +P+ P+ KE + P E T+ S P + A ++ P P+E + Sbjct: 363 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 422 Query: 889 THGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKR 948 T E PK TP E + T E APT K PA + Sbjct: 423 T---------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE-PAPTTTKKPAPTTPK 472 Query: 949 PEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQH- 1007 +++ +P LA K P ++ EE + Sbjct: 473 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA------PTTPEELAPTTPEEPTPTT 526 Query: 1008 -EEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPA 1066 EE P A+ P + +E A E P P A P Sbjct: 527 PEEPAPTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 585 Query: 1067 SPGVTPTQDAPETEACDETQEGRQQPV--PAPQQKMECWATSDAESPKLLASFPSAGEQG 1124 TP + AP+ A T+E PAP T+ E P+ Sbjct: 586 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTP- 644 Query: 1125 GEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEH--CLTSGEEASTSALRESCQ 1182 G A T A K+ AP++ T T T+ +E + + +E Sbjct: 645 --KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702 Query: 1183 A--EHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAA-------P 1233 + P + + P P +T + +T PD LS P A P Sbjct: 703 TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 762 Query: 1234 DTPYLHVDSAAQ----RGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAG 1289 P +A + A+D + P +P E E K+ A Sbjct: 763 GVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 822 Query: 1290 S--LAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKA 1347 + + +I ++ ++ +PK TT+ + + +++ AK K KA Sbjct: 823 TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 882 Query: 1348 AT 1349 T Sbjct: 883 TT 884 >gi|189181722 proteoglycan 4 isoform C [Homo sapiens] Length = 1311 Score = 89.0 bits (219), Expect = 6e-17 Identities = 192/885 (21%), Positives = 301/885 (34%), Gaps = 93/885 (10%) Query: 1771 RPQQAKEQPGPERPI--PAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPS 1828 + + K++P P+ P+ AG G +T + ++ T + P PS Sbjct: 111 KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 170 Query: 1829 MLP-SVPKKDAPRVMDKVTSDETR---------GAEGTESSPVADDI--IQPAAPADLE- 1875 + P S K+ ++K T+ ET+ +G E + A + I+ + DL Sbjct: 171 LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 230 Query: 1876 -SPTLAASSYHGDVVGQVSTDLIAQSISPAAAH--AGLPPSAAEHIVSPSAPAGDRVEA- 1931 S LA + + + + +P A P SAP + A Sbjct: 231 TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 290 Query: 1932 -STPSCPDPAKDLSRSSDSEEAFETPESTTPV----------KAPPAPPPPPPEVIPEPE 1980 +T S P K+ + ++ E A TP+ P K+ P P P P+ Sbjct: 291 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 350 Query: 1981 VSTQPPPEEPGCGSETVPV-PDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLD 2039 T P P E P P P + E +P P + +A KP ++ Sbjct: 351 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA---PKKPAPTTPKEPAP 407 Query: 2040 FDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASS 2099 E T T EP + K +T P +T S + + ++ Sbjct: 408 TTPKEPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS---PTT 463 Query: 2100 SGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDE 2159 + P A +T A +T K P P TTKKP T P + P E Sbjct: 464 TKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKPAPTTPKEPAPTTPKE 522 Query: 2160 ------ESLVPSG-ENLASETKTESAKT--EGPSPALLEE----TPLEPA-VGPKAACPL 2205 + L P+ E LA T + A T E +P EE TP EPA PKAA P Sbjct: 523 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 582 Query: 2206 DSESAEGVVP----PASGGGRVQNSPPVGRKTLPLTTAP----EAGEVTPSDSGGQEDSP 2257 + P P + +P T P TAP E TP +E +P Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 642 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS 2317 + + + DK + + P T K K P P L + Sbjct: 643 T---TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 699 Query: 2318 PPRSPAEPNDIPIA-KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDE 2376 P+ PA P KG + DK + T+ + +P P++ P+T Sbjct: 700 TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 759 Query: 2377 SVDPFKT--SSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPA-KKKKTPLKTDTFRV 2433 + T ++K P++ KSP SA + +P KTP T Sbjct: 760 TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 819 Query: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKL-AVTNQKWTCMTVDLEADK 2492 + ++ D + T A P+ + T E K+ A T Q + T D K Sbjct: 820 TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 879 Query: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552 + + L+ V TK + T E+ M K P++ PK +A + Sbjct: 880 ITTLKTTTLAPKVTTTKKTITTTEI----------MNK-----PEETAKPKDRAT----N 920 Query: 2553 TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 2597 + +P P + + PT S ++ + + P PR Sbjct: 921 SKATTPKPQKPTKAPKKPT-----STKKPKTMPRVRKPKTTPTPR 960 Score = 77.8 bits (190), Expect = 1e-13 Identities = 155/732 (21%), Positives = 241/732 (32%), Gaps = 70/732 (9%) Query: 1628 PRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE 1687 P +T P+P P EP T P A + A PAP T + Sbjct: 305 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 364 Query: 1688 VADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQ 1747 TP P + A E +T + A + P T + + P + + Sbjct: 365 -EPTPTTPKEPAPTTKEPAP----TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419 Query: 1748 DPACS---DKAPGMEGTAALHGDSPARPQQAKEQPG-PERPIPAGDGKVCVSSPPEPDET 1803 +P+ + + AP +A PA P K P P+ P P + ++P EP T Sbjct: 420 EPSPTTPKEPAPTTTKSAPTTTKEPA-PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 478 Query: 1804 HDPKLQHLAPEE-LHTDRESPRPGPSM--LPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 K P+E T + P P + P+ PK+ AP T ET + +P Sbjct: 479 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP-----TTPKETAPTTPKKLTP 533 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-V 1919 + + P P E P + T + +P A P + E Sbjct: 534 TTPEKLAPTTP---EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 590 Query: 1920 SPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEP 1979 +P PA + P+ P + + + P TTP K PAP P EP Sbjct: 591 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP 648 Query: 1980 EVST--QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYN 2037 +T +P P P + T P P + E +P P + E P Sbjct: 649 TSTTCDKPAPTTPKGTAPTTPKEPAPTTPK-EPAP-TTPKGTAPTTLKEPAPTTPKKPAP 706 Query: 2038 LDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDG 2096 + T + + +E T ++ + P + T + S+ Sbjct: 707 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 766 Query: 2097 ASSSGNPEAVALAPDAYSTGSSSASSTLKRTK-KPRPPSLKKKQTTKKPTETPPVKETQQ 2155 +++ P + +PD ST SA T K + P+ P + TTK P T P T Sbjct: 767 PTTTKEPTTIHKSPDE-STPELSAEPTPKALENSPKEPGV---PTTKTPAATKPEMTTTA 822 Query: 2156 EPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP 2215 ++ ET T + K + E+T +ES Sbjct: 823 ---KDKTTERDLRTTPETTTAAPKMTKETATTTEKT---------------TESKITATT 864 Query: 2216 PASGGGRVQNSPPVGRKTLPLTT-APEA----GEVTPSDSGGQEDSPAKGLSVRLEFDYS 2270 Q++ P TL TT AP+ +T ++ + + AK + Sbjct: 865 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 924 Query: 2271 EDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNT-PASPPRS-------- 2321 K + P + KKP +R+PK TP K+ +T P P S Sbjct: 925 TPKPQKPTKAPKKPTST---KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 981 Query: 2322 -PAEPNDIPIAK 2332 PN P +K Sbjct: 982 TTTRPNQTPNSK 993 Score = 77.0 bits (188), Expect = 3e-13 Identities = 130/630 (20%), Positives = 201/630 (31%), Gaps = 65/630 (10%) Query: 19 PRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVT 78 P S P + + TP P S + T ++ A P +P T Sbjct: 265 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT 324 Query: 79 EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSP 138 K+P P P + P+ + P P +P E P T+ P Sbjct: 325 ---KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 381 Query: 139 R----REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGI 194 +EPAP AP A P E +TP + P+ +E P + + + S Sbjct: 382 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAP 438 Query: 195 DQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPA 254 + +P + P +P ++E PA + TP+ PA Sbjct: 439 TTTKEPAPTTTKSAPTTP-----KEPSPTTTKEPAPTTPKEPAPTTP-KKPAPTTPKEPA 492 Query: 255 AAQQGTESSAVLEK-SPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLP 313 + +K +P P P P P A + P+ L A P Sbjct: 493 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 552 Query: 314 RSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPE-AGGSGKEALDTIDV 372 + PE +E A P+ P+P E A + KE T Sbjct: 553 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTPKEPAPTTPKEPAPTTPK 609 Query: 373 QGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPI 432 + P T +GT P + +P P P P L PT P S+ PA P Sbjct: 610 ETAPTT-PKGTAPTTL------KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 661 Query: 433 AVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHP----EGDPGE 488 + + K P + ++ + KG P E P Sbjct: 662 ------KGTAPTTPKEPAPTT---------------PKEPAPTTPKGTAPTTLKEPAPTT 700 Query: 489 VPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPG 548 P+P+E T+ P P PKE + P P P PK P+ + P Sbjct: 701 PKKPAPKELAP-TTTKGPTSTTSDKPAPTTPKETA-PTTPKEPAPTTPKKPAPTTPETPP 758 Query: 549 PTDGAKVHEDSTSPAVAKEGS---RSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PT + ++P KE + +SP +S P P + G + + Sbjct: 759 PTT-----SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 813 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQP 635 PE+ K +++ + R P + +A P Sbjct: 814 TKPEMTTTAKDK-TTERDLRTTPETTTAAP 842 Score = 74.7 bits (182), Expect = 1e-12 Identities = 160/747 (21%), Positives = 249/747 (33%), Gaps = 94/747 (12%) Query: 1781 PERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP-----RPGPSML----P 1831 P+ P P + ++P EP T E T +S P P+ P Sbjct: 254 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 313 Query: 1832 SVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA-------APADLESPTLAASSY 1884 + PK+ AP + T+ A T P +PA AP + PT Sbjct: 314 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE 373 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-VSPSAPAGDRVEASTPSCP-DPAKD 1942 + + + +P A P + E +P PA + +P+ P +PA Sbjct: 374 PAPTTKEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 432 Query: 1943 LSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVST--QPPPEEPGCGSETVP-- 1998 ++S+ + + P TT AP P P P EP +T +P P P + T P Sbjct: 433 TTKSAPTTT--KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 490 Query: 1999 -VPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 2057 P P+ + + P+ K A + L E + T + + Sbjct: 491 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPA 548 Query: 2058 DAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTG 2116 +E T + T + P + T ++ + ++ P A +T Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 608 Query: 2117 SSSASSTLKRT-----KKPRPPSLKKKQ-------TTKKPTETPPVKETQQEPDEESLVP 2164 +A +T K T K+P P + KK TTK+PT T K P + Sbjct: 609 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 668 Query: 2165 SGENLASETKTESAKT-EGPSPALLEE----TPLEPAVGPKAACPLDSESAEGVVP---- 2215 E + K + T +G +P L+E TP +PA PK P ++ Sbjct: 669 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA--PKELAPTTTKGPTSTTSDKPA 726 Query: 2216 PASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSS 2275 P + +P T P AP E P + E S S D+S+ Sbjct: 727 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS--EVSTPTTTKEPTTIHKSPDEST 784 Query: 2276 WDNQQENPPPTKKIGKK----PVAKMPLR-RPKM------KKTPEKLDNTPASPPRSPAE 2324 + E P + K P K P +P+M K T L TP + +P Sbjct: 785 PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK- 843 Query: 2325 PNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS 2384 + K T T T++ + + Q + DT + KT+ Sbjct: 844 -----MTKETATTT------------EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 886 Query: 2385 SKTP--SSPSKSPASFEIPASAMEANGVDGDGLN------KPAKKKKTPLKTDTFRVKKS 2436 + P ++ K+ + EI E N KP K K P K + K Sbjct: 887 TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS---TKK 943 Query: 2437 PKRSPLSDPPSQDPTPAATPETPPVIS 2463 PK P P PTP T P ++ Sbjct: 944 PKTMPRVRKPKTTPTPRKMTSTMPELN 970 Score = 68.9 bits (167), Expect = 7e-11 Identities = 174/870 (20%), Positives = 267/870 (30%), Gaps = 117/870 (13%) Query: 1365 DAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEK---PVL 1421 D + ET ++ + E + + K+ T+ TS++ T + + I K K P Sbjct: 176 DTSKETSLTVNK--ETTVETKETTTTNKQTSTDGKEKTTSAKE-TQSIEKTSAKDLAPTS 232 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPA--RLQVEKKQQLA 1479 LA P KA + G LT P P P P P K+ Sbjct: 233 KVLAKPTPKAET--TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 290 Query: 1480 GEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVP----PTLREDERPEGPG 1535 + + ++PA PA T + P KE A PT ++ P P Sbjct: 291 TTTKSAPTTPKEPAPTTTKEPAPTTPKE--PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 348 Query: 1536 AAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVER-----AAAFQVAPHSHGEEAVA 1590 P + + P+P + P A + AP + E A Sbjct: 349 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 408 Query: 1591 QDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRST-CAPSPQREVLTVPEANSE 1649 + P+ +E S A T P +T AP+ +E P E Sbjct: 409 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE--PSPTTTKE 466 Query: 1650 PW-TLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE--VADTPLEPGKVAG--AAGE 1704 P T P A A PAP T + TP EP A Sbjct: 467 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 526 Query: 1705 AEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAAL 1764 +T +T E A + + P T + + P + ++PA Sbjct: 527 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA-------------- 572 Query: 1765 HGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPR 1824 P P+ A P+ P P + ++P EP T + P+ +P Sbjct: 573 ----PTTPKAAAPNT-PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT-----APT 622 Query: 1825 PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSY 1884 P+ PKK AP+ + T+ E + +P P P + +PT Sbjct: 623 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE-PAPTTPKEPA 681 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLS 1944 G T L PA P A ++P+ G S P K+ + Sbjct: 682 PTTPKGTAPTTLK----EPAPT---TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 734 Query: 1945 RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPR 2004 ++ E A TP+ P P PPP + P + +P T + P Sbjct: 735 PTTPKEPAPTTPKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 792 Query: 2005 SDSVEGSPFRP---PSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTF---QTLEPRASD 2058 ++E SP P + + +A E A T D T T E + Sbjct: 793 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTT 852 Query: 2059 AKNQEGKVN------TRRKSTDSVP-----ISKSTLSRSLSLQASDFDGASSSGNPEAVA 2107 K E K+ T + D+ P + +TL+ ++ PE A Sbjct: 853 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETA 912 Query: 2108 LAPDAYSTGSSSASSTLKRTKKPRPPSLKKK----------------------------- 2138 D + ++ K TK P+ P+ KK Sbjct: 913 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 972 Query: 2139 --------QTTKKPTETPPVKETQQEPDEE 2160 QTT +P +TP K + P E Sbjct: 973 SRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1002 Score = 68.2 bits (165), Expect = 1e-10 Identities = 126/605 (20%), Positives = 192/605 (31%), Gaps = 101/605 (16%) Query: 2031 ASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPIS-------KSTL 2083 A SG N DF + DT T Q KV+T K T + PI+ S Sbjct: 129 AGSGLDNGDF-KVTTPDTSTT----------QHNKVSTSPKITTAKPINPRPSLPPNSDT 177 Query: 2084 SRSLSL-----------QASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRP 2132 S+ SL + + + +S+ E A + S +SA +K Sbjct: 178 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 237 Query: 2133 PSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETP 2192 P+ K + TTK P T P + T P E + E + K+ + P+P + P Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 297 Query: 2193 LEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVT---PSD 2249 PK P ++ P + P K+ P TT E T P+ Sbjct: 298 ----TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP-TTPKEPAPTTPKKPAP 352 Query: 2250 SGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPE 2309 + +E +P + K + P PT K K P K P Sbjct: 353 TTPKEPAP------------TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP- 399 Query: 2310 KLDNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYN 2368 TP P P +P EP P ++ +PK P + Sbjct: 400 ---TTPKEPAPTTPKEP----------------------APTTTKEPSPTTPKEPAPTTT 434 Query: 2369 FDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKT 2428 T + P T S + SP + + PA K P T Sbjct: 435 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 494 Query: 2429 DTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTV-- 2486 + + P P ++P P ET P + T EKLA T + T Sbjct: 495 TPKEPAPTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 553 Query: 2487 DLEADKQDYPQPSDLSTFVNET-KFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPK 2543 +L + P P+ T K ++P ++ + P++ PK Sbjct: 554 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP------------KEPAPTTPKEPAPTTPK 601 Query: 2544 KQALYLMFDTSQESPVKSSPVRMSE-------SPTPCSGSSFEETEALVNTAAKNQHPVP 2596 + A +T+ +P ++P + E P P + E T K P Sbjct: 602 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 661 Query: 2597 RGLAP 2601 +G AP Sbjct: 662 KGTAP 666 Score = 57.0 bits (136), Expect = 3e-07 Identities = 106/514 (20%), Positives = 169/514 (32%), Gaps = 67/514 (13%) Query: 2136 KKKQTTKKPTETPPVKETQQEPDEESLVPSGENLAS--ETKTESAKTEGPSPALLEETPL 2193 KK +T KKPT PPV + + S + +G+ + +T T SP + P Sbjct: 111 KKNRTKKKPTPKPPVVD-----EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKP- 164 Query: 2194 EPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQ 2253 + P+ + P +S++++ + S V ++ T E E T ++ Sbjct: 165 ---INPRPSLPPNSDTSK------------ETSLTVNKE-----TTVETKETTTTNKQTS 204 Query: 2254 EDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPV--AKMPLRRPKMKKTPEKL 2311 D K S + E +S ++ PT K+ KP A+ + P + E Sbjct: 205 TDGKEKTTSAK------ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 258 Query: 2312 DNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFD 2370 TP P +P EP I T P ++T +PK P + + Sbjct: 259 PTTPKEPASTTPKEPTPTTIKSAPTT--------PKEPAPTTTKSAPTTPKEPAPTTTKE 310 Query: 2371 P-DTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTD 2429 P T + P T P++ +P + + PA P + T K Sbjct: 311 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAP----TTPKEPAPTTPKEP 366 Query: 2430 TFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE 2489 T K P P +++P P E P T ++ A T K T E Sbjct: 367 TPTTPKEPA------PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 420 Query: 2490 AD--KQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQAL 2547 P P+ + TK +PT + + P P Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 480 Query: 2548 YLMFDTSQESPVKSSPVRMSESPTPCSGSSFEET---EALVNTAAKNQHPVPRGLAPNQE 2604 T+ + P ++P + P P + T E T + P+ L P Sbjct: 481 KKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP 536 Query: 2605 SHL--QVPEKSSQKELEAMGLGTPSEAIEITAPE 2636 L PEK + E + TP E T E Sbjct: 537 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 570 Score = 53.1 bits (126), Expect = 4e-06 Identities = 122/631 (19%), Positives = 194/631 (30%), Gaps = 82/631 (12%) Query: 137 SPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAV----PSAGRERQPKEEGQKSSFSFSS 192 +PR PN+ + ++++ +E + G+E+ + + S +S Sbjct: 166 NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAK-ETQSIEKTS 224 Query: 193 GIDQSPGMS----PVPLREPM-KAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQ 247 D +P P P E K P +P + KE A P + + S Sbjct: 225 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAP 282 Query: 248 VTPEAPAAAQQGTESSAVLEKSPL-----KPMAPIPQDPAPRASDRERGQGEAPPQYLTD 302 TP+ PA T+S+ K P +P P++PAP + Sbjct: 283 TTPKEPAPTT--TKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP------------- 327 Query: 303 DLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGS 362 P + A + A + P P P P+P E + Sbjct: 328 ---------APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPTPTTPKEPAPT 377 Query: 363 GKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSL 422 KE T + P T P + A P+ P +P+ T T+E P + Sbjct: 378 TKEPAPTTPKEPAP------TAPKK----PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPK 427 Query: 423 ASFPAA--QIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE 480 P P +EP ++ +S S KE + + Sbjct: 428 EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT------TPKEPAPTTPK 481 Query: 481 HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQS------------HEVQP 528 P + PAP+ + T++ P P P PKE + ++ P Sbjct: 482 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP 541 Query: 529 GAPPPPLPKAPSESA-RGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPD 587 P P P P E A P PT T+P A + KE AP P Sbjct: 542 TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK 601 Query: 588 GGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGP 647 +P +++ + K L +P+ + P + ++ + D P Sbjct: 602 --EPAPTTPKETAPTTPK---GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656 Query: 648 HSQTAEADASGLPHKLGEEDP--VLPPVPDGAGEPTVPEGAIWEGSGLQPK--CPDTLQS 703 T + A P + P P P G T+ E A PK P T + Sbjct: 657 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 716 Query: 704 REGLGRMESFLTLESEKSDFPPTPVAEVAPK 734 + T E + P A PK Sbjct: 717 PTSTTSDKPAPTTPKETAPTTPKEPAPTTPK 747 Score = 48.5 bits (114), Expect = 1e-04 Identities = 132/700 (18%), Positives = 207/700 (29%), Gaps = 153/700 (21%) Query: 266 LEKSPLKPMAPIPQ---DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPE 322 +EK+ K +AP + P P+A +G P+ T P+ + P+ Sbjct: 220 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT--------PKEPASTTPK 271 Query: 323 AEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRG 382 +P + A P+P A + KE T + P T Sbjct: 272 ------------EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 319 Query: 383 T-----KPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 +P +A P+ P +P+ T +E P + P P +EP Sbjct: 320 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-----PKEPTPTTPKEP 374 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQER 497 +++E P + PAP+ ++ Sbjct: 375 APTTKE--------------------------------------PAPTTPKEPAPTAPKK 396 Query: 498 GEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHE 557 ++ P P P KE S P AP+ + P T A Sbjct: 397 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 456 Query: 558 DSTSPAVAKE-GSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELS 616 SP KE +P + + P P +P ++ ++K+ E + Sbjct: 457 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 516 Query: 617 KPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDG 676 + + P + P K + P T E A P E P P P Sbjct: 517 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE---EPTPTTPEEP-- 571 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQ 736 PT P+ A P+T + E T E + PT E AP Sbjct: 572 --APTTPKAA----------APNTPKEPAPTTPKEPAPTTPKEPA---PTTPKETAPTTP 616 Query: 737 EGESTLEIRKMG------SCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAAD 790 +G + +++ E T+ +P CD P P+G Sbjct: 617 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-------APTTPKGT----- 664 Query: 791 LGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQ 850 P+ P E P ++ K +P+ P+ + LKE A Sbjct: 665 --------------APTTPKE----------PAPTTPK--EPAPTTPKGTAPTTLKEPA- 697 Query: 851 PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTL 910 T+P P K+ +++ P D PT E PK Sbjct: 698 ------PTTPKKPAPKELAPTTTK--GPTSTTSDKPAPT-------TPKETAPTTPKEPA 742 Query: 911 SDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPE 950 TP P E+ SE+S PT K P K P+ Sbjct: 743 PTTP-KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 781 Score = 37.4 bits (85), Expect = 0.22 Identities = 84/379 (22%), Positives = 116/379 (30%), Gaps = 42/379 (11%) Query: 1040 TGEAPPCQPDSVALLDAVPCLPA-LAPASPG-VTPTQDAPETEACDETQEGRQQPVPAPQ 1097 T E P P A P PA P P TP + AP T ++ PAP Sbjct: 378 TKEPAPTTPKEPA--PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPT 432 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQGGEAGAAE---TGGSAGAGDPGKQQAPEKPGEAT 1154 T+ +P S P+ ++ E T A K+ AP P E Sbjct: 433 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 492 Query: 1155 LSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQ 1214 + T E A T+ + + P P+ T + + Sbjct: 493 PT----------TPKEPAPTTTKKPA------------PTTPKEPAPTTPKETAPTTPKK 530 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGA----EDSGVKAVSSADPRAPGESPCP 1270 P E L PE AP TP + + E+ +A P P E Sbjct: 531 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 590 Query: 1271 VGEPPLALENAASLKLFAGSLAPLLQPGAAGGEI--PA-VQASSGSPK--ARTTEGPVDS 1325 + P AP G A + PA +PK A TT S Sbjct: 591 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 650 Query: 1326 MPCLDRMPLLAKGKQ-ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 C P KG T +E A T P A + +G A E + + P + Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 710 Query: 1385 KQGTSGGVDTSSEQIATLT 1403 T G T+S++ A T Sbjct: 711 PTTTKGPTSTTSDKPAPTT 729 Score = 32.0 bits (71), Expect = 9.3 Identities = 105/542 (19%), Positives = 166/542 (30%), Gaps = 43/542 (7%) Query: 831 QPSQAQPETSIFDVLKEQAQ--PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLP 888 +P+ P+ KE + P E T+ S P + A ++ P P+E + Sbjct: 404 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 463 Query: 889 THGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKR 948 T E PK TP E + T E APT K PA + Sbjct: 464 T---------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE-PAPTTTKKPAPTTPK 513 Query: 949 PEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQH- 1007 +++ +P LA K P ++ EE + Sbjct: 514 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA------PTTPEELAPTTPEEPTPTT 567 Query: 1008 -EEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPA 1066 EE P A+ P + +E A E P P A P Sbjct: 568 PEEPAPTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 626 Query: 1067 SPGVTPTQDAPETEACDETQEGRQQPV--PAPQQKMECWATSDAESPKLLASFPSAGEQG 1124 TP + AP+ A T+E PAP T+ E P+ Sbjct: 627 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTP- 685 Query: 1125 GEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEH--CLTSGEEASTSALRESCQ 1182 G A T A K+ AP++ T T T+ +E + + +E Sbjct: 686 --KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743 Query: 1183 A--EHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAA-------P 1233 + P + + P P +T + +T PD LS P A P Sbjct: 744 TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 803 Query: 1234 DTPYLHVDSAAQ----RGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAG 1289 P +A + A+D + P +P E E K+ A Sbjct: 804 GVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 863 Query: 1290 S--LAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKA 1347 + + +I ++ ++ +PK TT+ + + +++ AK K KA Sbjct: 864 TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 923 Query: 1348 AT 1349 T Sbjct: 924 TT 925 >gi|189181720 proteoglycan 4 isoform B [Homo sapiens] Length = 1363 Score = 89.0 bits (219), Expect = 6e-17 Identities = 192/885 (21%), Positives = 301/885 (34%), Gaps = 93/885 (10%) Query: 1771 RPQQAKEQPGPERPI--PAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPS 1828 + + K++P P+ P+ AG G +T + ++ T + P PS Sbjct: 163 KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 222 Query: 1829 MLP-SVPKKDAPRVMDKVTSDETR---------GAEGTESSPVADDI--IQPAAPADLE- 1875 + P S K+ ++K T+ ET+ +G E + A + I+ + DL Sbjct: 223 LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 282 Query: 1876 -SPTLAASSYHGDVVGQVSTDLIAQSISPAAAH--AGLPPSAAEHIVSPSAPAGDRVEA- 1931 S LA + + + + +P A P SAP + A Sbjct: 283 TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 342 Query: 1932 -STPSCPDPAKDLSRSSDSEEAFETPESTTPV----------KAPPAPPPPPPEVIPEPE 1980 +T S P K+ + ++ E A TP+ P K+ P P P P+ Sbjct: 343 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 402 Query: 1981 VSTQPPPEEPGCGSETVPV-PDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLD 2039 T P P E P P P + E +P P + +A KP ++ Sbjct: 403 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA---PKKPAPTTPKEPAP 459 Query: 2040 FDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASS 2099 E T T EP + K +T P +T S + + ++ Sbjct: 460 TTPKEPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS---PTT 515 Query: 2100 SGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDE 2159 + P A +T A +T K P P TTKKP T P + P E Sbjct: 516 TKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKPAPTTPKEPAPTTPKE 574 Query: 2160 ------ESLVPSG-ENLASETKTESAKT--EGPSPALLEE----TPLEPA-VGPKAACPL 2205 + L P+ E LA T + A T E +P EE TP EPA PKAA P Sbjct: 575 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 634 Query: 2206 DSESAEGVVP----PASGGGRVQNSPPVGRKTLPLTTAP----EAGEVTPSDSGGQEDSP 2257 + P P + +P T P TAP E TP +E +P Sbjct: 635 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 694 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS 2317 + + + DK + + P T K K P P L + Sbjct: 695 T---TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 751 Query: 2318 PPRSPAEPNDIPIA-KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDE 2376 P+ PA P KG + DK + T+ + +P P++ P+T Sbjct: 752 TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 811 Query: 2377 SVDPFKT--SSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPA-KKKKTPLKTDTFRV 2433 + T ++K P++ KSP SA + +P KTP T Sbjct: 812 TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 871 Query: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKL-AVTNQKWTCMTVDLEADK 2492 + ++ D + T A P+ + T E K+ A T Q + T D K Sbjct: 872 TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 931 Query: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552 + + L+ V TK + T E+ M K P++ PK +A + Sbjct: 932 ITTLKTTTLAPKVTTTKKTITTTEI----------MNK-----PEETAKPKDRAT----N 972 Query: 2553 TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 2597 + +P P + + PT S ++ + + P PR Sbjct: 973 SKATTPKPQKPTKAPKKPT-----STKKPKTMPRVRKPKTTPTPR 1012 Score = 77.8 bits (190), Expect = 1e-13 Identities = 155/732 (21%), Positives = 241/732 (32%), Gaps = 70/732 (9%) Query: 1628 PRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE 1687 P +T P+P P EP T P A + A PAP T + Sbjct: 357 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 416 Query: 1688 VADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQ 1747 TP P + A E +T + A + P T + + P + + Sbjct: 417 -EPTPTTPKEPAPTTKEPAP----TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 471 Query: 1748 DPACS---DKAPGMEGTAALHGDSPARPQQAKEQPG-PERPIPAGDGKVCVSSPPEPDET 1803 +P+ + + AP +A PA P K P P+ P P + ++P EP T Sbjct: 472 EPSPTTPKEPAPTTTKSAPTTTKEPA-PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530 Query: 1804 HDPKLQHLAPEE-LHTDRESPRPGPSM--LPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 K P+E T + P P + P+ PK+ AP T ET + +P Sbjct: 531 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP-----TTPKETAPTTPKKLTP 585 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-V 1919 + + P P E P + T + +P A P + E Sbjct: 586 TTPEKLAPTTP---EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 642 Query: 1920 SPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEP 1979 +P PA + P+ P + + + P TTP K PAP P EP Sbjct: 643 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP 700 Query: 1980 EVST--QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYN 2037 +T +P P P + T P P + E +P P + E P Sbjct: 701 TSTTCDKPAPTTPKGTAPTTPKEPAPTTPK-EPAP-TTPKGTAPTTLKEPAPTTPKKPAP 758 Query: 2038 LDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDG 2096 + T + + +E T ++ + P + T + S+ Sbjct: 759 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 818 Query: 2097 ASSSGNPEAVALAPDAYSTGSSSASSTLKRTK-KPRPPSLKKKQTTKKPTETPPVKETQQ 2155 +++ P + +PD ST SA T K + P+ P + TTK P T P T Sbjct: 819 PTTTKEPTTIHKSPDE-STPELSAEPTPKALENSPKEPGV---PTTKTPAATKPEMTTTA 874 Query: 2156 EPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP 2215 ++ ET T + K + E+T +ES Sbjct: 875 ---KDKTTERDLRTTPETTTAAPKMTKETATTTEKT---------------TESKITATT 916 Query: 2216 PASGGGRVQNSPPVGRKTLPLTT-APEA----GEVTPSDSGGQEDSPAKGLSVRLEFDYS 2270 Q++ P TL TT AP+ +T ++ + + AK + Sbjct: 917 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 976 Query: 2271 EDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNT-PASPPRS-------- 2321 K + P + KKP +R+PK TP K+ +T P P S Sbjct: 977 TPKPQKPTKAPKKPTST---KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 1033 Query: 2322 -PAEPNDIPIAK 2332 PN P +K Sbjct: 1034 TTTRPNQTPNSK 1045 Score = 77.0 bits (188), Expect = 3e-13 Identities = 130/630 (20%), Positives = 201/630 (31%), Gaps = 65/630 (10%) Query: 19 PRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVT 78 P S P + + TP P S + T ++ A P +P T Sbjct: 317 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT 376 Query: 79 EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSP 138 K+P P P + P+ + P P +P E P T+ P Sbjct: 377 ---KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 433 Query: 139 R----REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGI 194 +EPAP AP A P E +TP + P+ +E P + + + S Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAP 490 Query: 195 DQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPA 254 + +P + P +P ++E PA + TP+ PA Sbjct: 491 TTTKEPAPTTTKSAPTTP-----KEPSPTTTKEPAPTTPKEPAPTTP-KKPAPTTPKEPA 544 Query: 255 AAQQGTESSAVLEK-SPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLP 313 + +K +P P P P P A + P+ L A P Sbjct: 545 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 604 Query: 314 RSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPE-AGGSGKEALDTIDV 372 + PE +E A P+ P+P E A + KE T Sbjct: 605 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTPKEPAPTTPKEPAPTTPK 661 Query: 373 QGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPI 432 + P T +GT P + +P P P P L PT P S+ PA P Sbjct: 662 ETAPTT-PKGTAPTTL------KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 713 Query: 433 AVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHP----EGDPGE 488 + + K P + ++ + KG P E P Sbjct: 714 ------KGTAPTTPKEPAPTT---------------PKEPAPTTPKGTAPTTLKEPAPTT 752 Query: 489 VPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPG 548 P+P+E T+ P P PKE + P P P PK P+ + P Sbjct: 753 PKKPAPKELAP-TTTKGPTSTTSDKPAPTTPKETA-PTTPKEPAPTTPKKPAPTTPETPP 810 Query: 549 PTDGAKVHEDSTSPAVAKEGS---RSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PT + ++P KE + +SP +S P P + G + + Sbjct: 811 PTT-----SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 865 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQP 635 PE+ K +++ + R P + +A P Sbjct: 866 TKPEMTTTAKDK-TTERDLRTTPETTTAAP 894 Score = 74.7 bits (182), Expect = 1e-12 Identities = 160/747 (21%), Positives = 249/747 (33%), Gaps = 94/747 (12%) Query: 1781 PERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP-----RPGPSML----P 1831 P+ P P + ++P EP T E T +S P P+ P Sbjct: 306 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 365 Query: 1832 SVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA-------APADLESPTLAASSY 1884 + PK+ AP + T+ A T P +PA AP + PT Sbjct: 366 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE 425 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-VSPSAPAGDRVEASTPSCP-DPAKD 1942 + + + +P A P + E +P PA + +P+ P +PA Sbjct: 426 PAPTTKEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 484 Query: 1943 LSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVST--QPPPEEPGCGSETVP-- 1998 ++S+ + + P TT AP P P P EP +T +P P P + T P Sbjct: 485 TTKSAPTTT--KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 542 Query: 1999 -VPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 2057 P P+ + + P+ K A + L E + T + + Sbjct: 543 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPA 600 Query: 2058 DAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTG 2116 +E T + T + P + T ++ + ++ P A +T Sbjct: 601 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660 Query: 2117 SSSASSTLKRT-----KKPRPPSLKKKQ-------TTKKPTETPPVKETQQEPDEESLVP 2164 +A +T K T K+P P + KK TTK+PT T K P + Sbjct: 661 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 720 Query: 2165 SGENLASETKTESAKT-EGPSPALLEE----TPLEPAVGPKAACPLDSESAEGVVP---- 2215 E + K + T +G +P L+E TP +PA PK P ++ Sbjct: 721 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA--PKELAPTTTKGPTSTTSDKPA 778 Query: 2216 PASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSS 2275 P + +P T P AP E P + E S S D+S+ Sbjct: 779 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS--EVSTPTTTKEPTTIHKSPDEST 836 Query: 2276 WDNQQENPPPTKKIGKK----PVAKMPLR-RPKM------KKTPEKLDNTPASPPRSPAE 2324 + E P + K P K P +P+M K T L TP + +P Sbjct: 837 PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK- 895 Query: 2325 PNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS 2384 + K T T T++ + + Q + DT + KT+ Sbjct: 896 -----MTKETATTT------------EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 938 Query: 2385 SKTP--SSPSKSPASFEIPASAMEANGVDGDGLN------KPAKKKKTPLKTDTFRVKKS 2436 + P ++ K+ + EI E N KP K K P K + K Sbjct: 939 TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS---TKK 995 Query: 2437 PKRSPLSDPPSQDPTPAATPETPPVIS 2463 PK P P PTP T P ++ Sbjct: 996 PKTMPRVRKPKTTPTPRKMTSTMPELN 1022 Score = 68.9 bits (167), Expect = 7e-11 Identities = 174/870 (20%), Positives = 267/870 (30%), Gaps = 117/870 (13%) Query: 1365 DAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEK---PVL 1421 D + ET ++ + E + + K+ T+ TS++ T + + I K K P Sbjct: 228 DTSKETSLTVNK--ETTVETKETTTTNKQTSTDGKEKTTSAKE-TQSIEKTSAKDLAPTS 284 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPA--RLQVEKKQQLA 1479 LA P KA + G LT P P P P P K+ Sbjct: 285 KVLAKPTPKAET--TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 342 Query: 1480 GEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVP----PTLREDERPEGPG 1535 + + ++PA PA T + P KE A PT ++ P P Sbjct: 343 TTTKSAPTTPKEPAPTTTKEPAPTTPKE--PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 400 Query: 1536 AAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVER-----AAAFQVAPHSHGEEAVA 1590 P + + P+P + P A + AP + E A Sbjct: 401 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460 Query: 1591 QDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRST-CAPSPQREVLTVPEANSE 1649 + P+ +E S A T P +T AP+ +E P E Sbjct: 461 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE--PSPTTTKE 518 Query: 1650 PW-TLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE--VADTPLEPGKVAG--AAGE 1704 P T P A A PAP T + TP EP A Sbjct: 519 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 578 Query: 1705 AEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAAL 1764 +T +T E A + + P T + + P + ++PA Sbjct: 579 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA-------------- 624 Query: 1765 HGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPR 1824 P P+ A P+ P P + ++P EP T + P+ +P Sbjct: 625 ----PTTPKAAAPNT-PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT-----APT 674 Query: 1825 PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSY 1884 P+ PKK AP+ + T+ E + +P P P + +PT Sbjct: 675 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE-PAPTTPKEPA 733 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLS 1944 G T L PA P A ++P+ G S P K+ + Sbjct: 734 PTTPKGTAPTTLK----EPAPT---TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 786 Query: 1945 RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPR 2004 ++ E A TP+ P P PPP + P + +P T + P Sbjct: 787 PTTPKEPAPTTPKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 844 Query: 2005 SDSVEGSPFRP---PSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTF---QTLEPRASD 2058 ++E SP P + + +A E A T D T T E + Sbjct: 845 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTT 904 Query: 2059 AKNQEGKVN------TRRKSTDSVP-----ISKSTLSRSLSLQASDFDGASSSGNPEAVA 2107 K E K+ T + D+ P + +TL+ ++ PE A Sbjct: 905 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETA 964 Query: 2108 LAPDAYSTGSSSASSTLKRTKKPRPPSLKKK----------------------------- 2138 D + ++ K TK P+ P+ KK Sbjct: 965 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 1024 Query: 2139 --------QTTKKPTETPPVKETQQEPDEE 2160 QTT +P +TP K + P E Sbjct: 1025 SRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1054 Score = 68.2 bits (165), Expect = 1e-10 Identities = 126/605 (20%), Positives = 192/605 (31%), Gaps = 101/605 (16%) Query: 2031 ASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPIS-------KSTL 2083 A SG N DF + DT T Q KV+T K T + PI+ S Sbjct: 181 AGSGLDNGDF-KVTTPDTSTT----------QHNKVSTSPKITTAKPINPRPSLPPNSDT 229 Query: 2084 SRSLSL-----------QASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRP 2132 S+ SL + + + +S+ E A + S +SA +K Sbjct: 230 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 289 Query: 2133 PSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETP 2192 P+ K + TTK P T P + T P E + E + K+ + P+P + P Sbjct: 290 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 349 Query: 2193 LEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVT---PSD 2249 PK P ++ P + P K+ P TT E T P+ Sbjct: 350 ----TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP-TTPKEPAPTTPKKPAP 404 Query: 2250 SGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPE 2309 + +E +P + K + P PT K K P K P Sbjct: 405 TTPKEPAP------------TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP- 451 Query: 2310 KLDNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYN 2368 TP P P +P EP P ++ +PK P + Sbjct: 452 ---TTPKEPAPTTPKEP----------------------APTTTKEPSPTTPKEPAPTTT 486 Query: 2369 FDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKT 2428 T + P T S + SP + + PA K P T Sbjct: 487 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 546 Query: 2429 DTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTV-- 2486 + + P P ++P P ET P + T EKLA T + T Sbjct: 547 TPKEPAPTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 605 Query: 2487 DLEADKQDYPQPSDLSTFVNET-KFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPK 2543 +L + P P+ T K ++P ++ + P++ PK Sbjct: 606 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP------------KEPAPTTPKEPAPTTPK 653 Query: 2544 KQALYLMFDTSQESPVKSSPVRMSE-------SPTPCSGSSFEETEALVNTAAKNQHPVP 2596 + A +T+ +P ++P + E P P + E T K P Sbjct: 654 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 713 Query: 2597 RGLAP 2601 +G AP Sbjct: 714 KGTAP 718 Score = 63.5 bits (153), Expect = 3e-09 Identities = 125/613 (20%), Positives = 206/613 (33%), Gaps = 87/613 (14%) Query: 2051 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDF-DGASSSGNPEAVALA 2109 T P + A G T + +T P + +++ + + S S N E+ + Sbjct: 70 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSS-- 127 Query: 2110 PDAYSTGSSSASSTLKRTKKPRPPSL-------------KKKQTTKKPTETPPVKETQQE 2156 S+ SSS+SST+++ K + + KK +T KKPT PPV + Sbjct: 128 ----SSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD---- 179 Query: 2157 PDEESLVPSGENLAS--ETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVV 2214 + S + +G+ + +T T SP + P + P+ + P +S++++ Sbjct: 180 -EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKP----INPRPSLPPNSDTSK--- 231 Query: 2215 PPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKS 2274 + S V ++ T E E T ++ D K S + E +S Sbjct: 232 ---------ETSLTVNKE-----TTVETKETTTTNKQTSTDGKEKTTSAK------ETQS 271 Query: 2275 SWDNQQENPPPTKKIGKKPV--AKMPLRRPKMKKTPEKLDNTPASP-PRSPAEPNDIPIA 2331 ++ PT K+ KP A+ + P + E TP P +P EP I Sbjct: 272 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 331 Query: 2332 KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDP-DTCDESVDPFKTSSKTPSS 2390 T P ++T +PK P + +P T + P T P++ Sbjct: 332 SAPTT--------PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 383 Query: 2391 PSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDP 2450 +P + + PA P + T K T K P P +++P Sbjct: 384 TKSAPTTPKEPAPTTPKKPAP----TTPKEPAPTTPKEPTPTTPKEPA------PTTKEP 433 Query: 2451 TPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEAD--KQDYPQPSDLSTFVNET 2508 P E P T ++ A T K T E P P+ + T Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493 Query: 2509 KFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSE 2568 K +PT + + P P T+ + P ++P + Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----K 549 Query: 2569 SPTPCSGSSFEET---EALVNTAAKNQHPVPRGLAPNQESHL--QVPEKSSQKELEAMGL 2623 P P + T E T + P+ L P L PEK + E + Sbjct: 550 EPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP 609 Query: 2624 GTPSEAIEITAPE 2636 TP E T E Sbjct: 610 TTPEEPTPTTPEE 622 Score = 53.9 bits (128), Expect = 2e-06 Identities = 146/772 (18%), Positives = 237/772 (30%), Gaps = 99/772 (12%) Query: 8 SDNQRTLSAQTPRSAQPPGN--------SQNIKRKQQDTPGSPDHRDASSIGSVGLGGFC 59 S +T+ + T RS +PP S+ I + + +SS S Sbjct: 82 SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKI 141 Query: 60 TASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPE 119 +S++SA+ +V + +K+ + P PP E + F P+ Sbjct: 142 KSSKNSAANRELQKKLKVKDNKKNRTKKKPT-----PKPPVVDEAGSGLDNGDFKVTTPD 196 Query: 120 GCLASPAAAPEDGPQTQS----PRREPAPNAPGDIAAAFPAERDSSTPYQEIAAV----P 171 T + PR PN+ + ++++ +E Sbjct: 197 TSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS 256 Query: 172 SAGRERQPKEEGQKSSFSFSSGIDQSPGMS----PVPLREPM-KAPLCGEGDQPGGFESQ 226 + G+E+ + + S +S D +P P P E K P +P + Sbjct: 257 TDGKEKTTSAK-ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTT 313 Query: 227 EKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPL-----KPMAPIPQDP 281 KE A P + + S TP+ PA T+S+ K P +P P++P Sbjct: 314 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTT--TKSAPTTPKEPAPTTTKEPAPTTPKEP 371 Query: 282 APRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYL 341 AP + P + A + A + P Sbjct: 372 APTTTKEP----------------------APTTTKSAPTTPKEPAPTTPKKPAPTTPKE 409 Query: 342 PHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGL 401 P P P+P E + KE T + P T P + A P+ Sbjct: 410 PAPTTP-KEPTPTTPKEPAPTTKEPAPTTPKEPAP------TAPKK----PAPTTPKEPA 458 Query: 402 PVSPEPSLLTPTEEAHPASSLASFPAA--QIPIAVEEPGSSSRESVSKAGMPVSADAAKE 459 P +P+ T T+E P + P P +EP ++ +S S KE Sbjct: 459 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 518 Query: 460 VVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLP 519 + + P + PAP+ + T++ P P P P Sbjct: 519 PAPT------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP 572 Query: 520 KEQS------------HEVQPGAPPPPLPKAPSESA-RGPPGPTDGAKVHEDSTSPAVAK 566 KE + ++ P P P P P E A P PT T+P A Sbjct: 573 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 632 Query: 567 EGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRD 626 + KE AP P +P +++ + K L +P+ + Sbjct: 633 PNTPKEPAPTTPKEPAPTTPK--EPAPTTPKETAPTTPK---GTAPTTLKEPAPTTPKKP 687 Query: 627 HPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDP--VLPPVPDGAGEPTVPE 684 P + ++ + D P T + A P + P P P G T+ E Sbjct: 688 APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE 747 Query: 685 GAIWEGSGLQPK--CPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPK 734 A PK P T + + T E + P A PK Sbjct: 748 PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK 799 Score = 48.5 bits (114), Expect = 1e-04 Identities = 132/700 (18%), Positives = 207/700 (29%), Gaps = 153/700 (21%) Query: 266 LEKSPLKPMAPIPQ---DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPE 322 +EK+ K +AP + P P+A +G P+ T P+ + P+ Sbjct: 272 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT--------PKEPASTTPK 323 Query: 323 AEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRG 382 +P + A P+P A + KE T + P T Sbjct: 324 ------------EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 371 Query: 383 T-----KPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 +P +A P+ P +P+ T +E P + P P +EP Sbjct: 372 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-----PKEPTPTTPKEP 426 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQER 497 +++E P + PAP+ ++ Sbjct: 427 APTTKE--------------------------------------PAPTTPKEPAPTAPKK 448 Query: 498 GEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHE 557 ++ P P P KE S P AP+ + P T A Sbjct: 449 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 508 Query: 558 DSTSPAVAKE-GSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELS 616 SP KE +P + + P P +P ++ ++K+ E + Sbjct: 509 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 568 Query: 617 KPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDG 676 + + P + P K + P T E A P E P P P Sbjct: 569 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE---EPTPTTPEEP-- 623 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQ 736 PT P+ A P+T + E T E + PT E AP Sbjct: 624 --APTTPKAA----------APNTPKEPAPTTPKEPAPTTPKEPA---PTTPKETAPTTP 668 Query: 737 EGESTLEIRKMG------SCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAAD 790 +G + +++ E T+ +P CD P P+G Sbjct: 669 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-------APTTPKGT----- 716 Query: 791 LGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQ 850 P+ P E P ++ K +P+ P+ + LKE A Sbjct: 717 --------------APTTPKE----------PAPTTPK--EPAPTTPKGTAPTTLKEPA- 749 Query: 851 PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTL 910 T+P P K+ +++ P D PT E PK Sbjct: 750 ------PTTPKKPAPKELAPTTTK--GPTSTTSDKPAPT-------TPKETAPTTPKEPA 794 Query: 911 SDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPE 950 TP P E+ SE+S PT K P K P+ Sbjct: 795 PTTP-KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 833 Score = 37.4 bits (85), Expect = 0.22 Identities = 84/379 (22%), Positives = 116/379 (30%), Gaps = 42/379 (11%) Query: 1040 TGEAPPCQPDSVALLDAVPCLPA-LAPASPG-VTPTQDAPETEACDETQEGRQQPVPAPQ 1097 T E P P A P PA P P TP + AP T ++ PAP Sbjct: 430 TKEPAPTTPKEPA--PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPT 484 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQGGEAGAAE---TGGSAGAGDPGKQQAPEKPGEAT 1154 T+ +P S P+ ++ E T A K+ AP P E Sbjct: 485 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 544 Query: 1155 LSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQ 1214 + T E A T+ + + P P+ T + + Sbjct: 545 PT----------TPKEPAPTTTKKPA------------PTTPKEPAPTTPKETAPTTPKK 582 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGA----EDSGVKAVSSADPRAPGESPCP 1270 P E L PE AP TP + + E+ +A P P E Sbjct: 583 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 642 Query: 1271 VGEPPLALENAASLKLFAGSLAPLLQPGAAGGEI--PA-VQASSGSPK--ARTTEGPVDS 1325 + P AP G A + PA +PK A TT S Sbjct: 643 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 702 Query: 1326 MPCLDRMPLLAKGKQ-ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 C P KG T +E A T P A + +G A E + + P + Sbjct: 703 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 762 Query: 1385 KQGTSGGVDTSSEQIATLT 1403 T G T+S++ A T Sbjct: 763 PTTTKGPTSTTSDKPAPTT 781 Score = 33.1 bits (74), Expect = 4.2 Identities = 179/964 (18%), Positives = 308/964 (31%), Gaps = 80/964 (8%) Query: 415 EAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSD 474 E H +S S A P + + + + ++ P + K+V+++ + E VS+ Sbjct: 65 EVHNPTSPPSSKKAPPPSGASQ---TIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSE 121 Query: 475 LGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPP 534 E + + ++ N+ + E+Q + K ++ + +P PP Sbjct: 122 ---NQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKK-KPTPKPPV 177 Query: 535 LPKAPSESARGP----PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGD 590 + +A S G T + ++ STSP + +P S + + Sbjct: 178 VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 237 Query: 591 PGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQ 650 E + ++ + E + + + +S + S+ P K A T P ++ Sbjct: 238 NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT--PKAE 295 Query: 651 TAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPK--CPDTLQSREGLG 708 T + K E P P P + P P + + PK P T +S Sbjct: 296 TTTKGPALTTPK--EPTPTTPKEP-ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP 352 Query: 709 RMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACD 768 + + T K P TP E AP + + + + E T+P +P Sbjct: 353 KEPAPTTT---KEPAPTTP-KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP----AP 404 Query: 769 ASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEK 828 + +E P P T ++ P+ P E A + P ++ K Sbjct: 405 TTPKEPAPTTPKEPTPTTPKEPAPTT-------KEPAPTTPKEP--APTAPKKPAPTTPK 455 Query: 829 HLQPSQAQPETSIFDVLKEQAQ--PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNN 886 +P+ P+ KE + P E T+ S P + A ++ P P+E + Sbjct: 456 --EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513 Query: 887 LPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGE 946 T E PK TP E + T E APT K PA Sbjct: 514 TTT---------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE-PAPTTTKKPAPTT 563 Query: 947 KRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQ 1006 + +++ +P LA K P ++ EE + Sbjct: 564 PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA------PTTPEELAPTTPEEPTP 617 Query: 1007 H--EEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALA 1064 EE P A+ P + +E A E P P A P Sbjct: 618 TTPEEPAPTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTL 676 Query: 1065 PASPGVTPTQDAPETEACDETQEGRQQPV--PAPQQKMECWATSDAESPKLLASFPSAGE 1122 TP + AP+ A T+E PAP T+ E P+ Sbjct: 677 KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTT 736 Query: 1123 QGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEH--CLTSGEEASTSALRES 1180 G A T A K+ AP++ T T T+ +E + + +E Sbjct: 737 P---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 793 Query: 1181 CQA--EHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAA------ 1232 + P + + P P +T + +T PD LS P A Sbjct: 794 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 853 Query: 1233 -PDTPYLHVDSAAQ----RGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLF 1287 P P +A + A+D + P +P E E K+ Sbjct: 854 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT 913 Query: 1288 AGS--LAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEE 1345 A + + +I ++ ++ +PK TT+ + + +++ AK K Sbjct: 914 ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS 973 Query: 1346 KAAT 1349 KA T Sbjct: 974 KATT 977 >gi|67190163 proteoglycan 4 isoform A [Homo sapiens] Length = 1404 Score = 89.0 bits (219), Expect = 6e-17 Identities = 192/885 (21%), Positives = 301/885 (34%), Gaps = 93/885 (10%) Query: 1771 RPQQAKEQPGPERPI--PAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPS 1828 + + K++P P+ P+ AG G +T + ++ T + P PS Sbjct: 204 KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 263 Query: 1829 MLP-SVPKKDAPRVMDKVTSDETR---------GAEGTESSPVADDI--IQPAAPADLE- 1875 + P S K+ ++K T+ ET+ +G E + A + I+ + DL Sbjct: 264 LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 323 Query: 1876 -SPTLAASSYHGDVVGQVSTDLIAQSISPAAAH--AGLPPSAAEHIVSPSAPAGDRVEA- 1931 S LA + + + + +P A P SAP + A Sbjct: 324 TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 383 Query: 1932 -STPSCPDPAKDLSRSSDSEEAFETPESTTPV----------KAPPAPPPPPPEVIPEPE 1980 +T S P K+ + ++ E A TP+ P K+ P P P P+ Sbjct: 384 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 443 Query: 1981 VSTQPPPEEPGCGSETVPV-PDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLD 2039 T P P E P P P + E +P P + +A KP ++ Sbjct: 444 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA---PKKPAPTTPKEPAP 500 Query: 2040 FDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASS 2099 E T T EP + K +T P +T S + + ++ Sbjct: 501 TTPKEPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS---PTT 556 Query: 2100 SGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDE 2159 + P A +T A +T K P P TTKKP T P + P E Sbjct: 557 TKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKPAPTTPKEPAPTTPKE 615 Query: 2160 ------ESLVPSG-ENLASETKTESAKT--EGPSPALLEE----TPLEPA-VGPKAACPL 2205 + L P+ E LA T + A T E +P EE TP EPA PKAA P Sbjct: 616 TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPN 675 Query: 2206 DSESAEGVVP----PASGGGRVQNSPPVGRKTLPLTTAP----EAGEVTPSDSGGQEDSP 2257 + P P + +P T P TAP E TP +E +P Sbjct: 676 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 735 Query: 2258 AKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPAS 2317 + + + DK + + P T K K P P L + Sbjct: 736 T---TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 792 Query: 2318 PPRSPAEPNDIPIA-KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDE 2376 P+ PA P KG + DK + T+ + +P P++ P+T Sbjct: 793 TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 852 Query: 2377 SVDPFKT--SSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPA-KKKKTPLKTDTFRV 2433 + T ++K P++ KSP SA + +P KTP T Sbjct: 853 TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 912 Query: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKL-AVTNQKWTCMTVDLEADK 2492 + ++ D + T A P+ + T E K+ A T Q + T D K Sbjct: 913 TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 972 Query: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552 + + L+ V TK + T E+ M K P++ PK +A + Sbjct: 973 ITTLKTTTLAPKVTTTKKTITTTEI----------MNK-----PEETAKPKDRAT----N 1013 Query: 2553 TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPR 2597 + +P P + + PT S ++ + + P PR Sbjct: 1014 SKATTPKPQKPTKAPKKPT-----STKKPKTMPRVRKPKTTPTPR 1053 Score = 77.8 bits (190), Expect = 1e-13 Identities = 155/732 (21%), Positives = 241/732 (32%), Gaps = 70/732 (9%) Query: 1628 PRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE 1687 P +T P+P P EP T P A + A PAP T + Sbjct: 398 PTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK 457 Query: 1688 VADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQ 1747 TP P + A E +T + A + P T + + P + + Sbjct: 458 -EPTPTTPKEPAPTTKEPAP----TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 512 Query: 1748 DPACS---DKAPGMEGTAALHGDSPARPQQAKEQPG-PERPIPAGDGKVCVSSPPEPDET 1803 +P+ + + AP +A PA P K P P+ P P + ++P EP T Sbjct: 513 EPSPTTPKEPAPTTTKSAPTTTKEPA-PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571 Query: 1804 HDPKLQHLAPEE-LHTDRESPRPGPSM--LPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 K P+E T + P P + P+ PK+ AP T ET + +P Sbjct: 572 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP-----TTPKETAPTTPKKLTP 626 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-V 1919 + + P P E P + T + +P A P + E Sbjct: 627 TTPEKLAPTTP---EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 683 Query: 1920 SPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEP 1979 +P PA + P+ P + + + P TTP K PAP P EP Sbjct: 684 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKEP 741 Query: 1980 EVST--QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYN 2037 +T +P P P + T P P + E +P P + E P Sbjct: 742 TSTTCDKPAPTTPKGTAPTTPKEPAPTTPK-EPAP-TTPKGTAPTTLKEPAPTTPKKPAP 799 Query: 2038 LDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDG 2096 + T + + +E T ++ + P + T + S+ Sbjct: 800 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 859 Query: 2097 ASSSGNPEAVALAPDAYSTGSSSASSTLKRTK-KPRPPSLKKKQTTKKPTETPPVKETQQ 2155 +++ P + +PD ST SA T K + P+ P + TTK P T P T Sbjct: 860 PTTTKEPTTIHKSPDE-STPELSAEPTPKALENSPKEPGV---PTTKTPAATKPEMTTTA 915 Query: 2156 EPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP 2215 ++ ET T + K + E+T +ES Sbjct: 916 ---KDKTTERDLRTTPETTTAAPKMTKETATTTEKT---------------TESKITATT 957 Query: 2216 PASGGGRVQNSPPVGRKTLPLTT-APEA----GEVTPSDSGGQEDSPAKGLSVRLEFDYS 2270 Q++ P TL TT AP+ +T ++ + + AK + Sbjct: 958 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 1017 Query: 2271 EDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNT-PASPPRS-------- 2321 K + P + KKP +R+PK TP K+ +T P P S Sbjct: 1018 TPKPQKPTKAPKKPTST---KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 1074 Query: 2322 -PAEPNDIPIAK 2332 PN P +K Sbjct: 1075 TTTRPNQTPNSK 1086 Score = 77.0 bits (188), Expect = 3e-13 Identities = 130/630 (20%), Positives = 201/630 (31%), Gaps = 65/630 (10%) Query: 19 PRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVT 78 P S P + + TP P S + T ++ A P +P T Sbjct: 358 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT 417 Query: 79 EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSP 138 K+P P P + P+ + P P +P E P T+ P Sbjct: 418 ---KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 474 Query: 139 R----REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGI 194 +EPAP AP A P E +TP + P+ +E P + + + S Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAP 531 Query: 195 DQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPA 254 + +P + P +P ++E PA + TP+ PA Sbjct: 532 TTTKEPAPTTTKSAPTTP-----KEPSPTTTKEPAPTTPKEPAPTTP-KKPAPTTPKEPA 585 Query: 255 AAQQGTESSAVLEK-SPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLP 313 + +K +P P P P P A + P+ L A P Sbjct: 586 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 645 Query: 314 RSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPE-AGGSGKEALDTIDV 372 + PE +E A P+ P+P E A + KE T Sbjct: 646 EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTPKEPAPTTPKEPAPTTPK 702 Query: 373 QGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPI 432 + P T +GT P + +P P P P L PT P S+ PA P Sbjct: 703 ETAPTT-PKGTAPTTL------KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 754 Query: 433 AVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHP----EGDPGE 488 + + K P + ++ + KG P E P Sbjct: 755 ------KGTAPTTPKEPAPTT---------------PKEPAPTTPKGTAPTTLKEPAPTT 793 Query: 489 VPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPG 548 P+P+E T+ P P PKE + P P P PK P+ + P Sbjct: 794 PKKPAPKELAP-TTTKGPTSTTSDKPAPTTPKETA-PTTPKEPAPTTPKKPAPTTPETPP 851 Query: 549 PTDGAKVHEDSTSPAVAKEGS---RSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PT + ++P KE + +SP +S P P + G + + Sbjct: 852 PTT-----SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 906 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQP 635 PE+ K +++ + R P + +A P Sbjct: 907 TKPEMTTTAKDK-TTERDLRTTPETTTAAP 935 Score = 74.7 bits (182), Expect = 1e-12 Identities = 160/747 (21%), Positives = 249/747 (33%), Gaps = 94/747 (12%) Query: 1781 PERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP-----RPGPSML----P 1831 P+ P P + ++P EP T E T +S P P+ P Sbjct: 347 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 406 Query: 1832 SVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA-------APADLESPTLAASSY 1884 + PK+ AP + T+ A T P +PA AP + PT Sbjct: 407 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE 466 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHI-VSPSAPAGDRVEASTPSCP-DPAKD 1942 + + + +P A P + E +P PA + +P+ P +PA Sbjct: 467 PAPTTKEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 525 Query: 1943 LSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVST--QPPPEEPGCGSETVP-- 1998 ++S+ + + P TT AP P P P EP +T +P P P + T P Sbjct: 526 TTKSAPTTT--KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 583 Query: 1999 -VPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRAS 2057 P P+ + + P+ K A + L E + T + + Sbjct: 584 PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPA 641 Query: 2058 DAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTG 2116 +E T + T + P + T ++ + ++ P A +T Sbjct: 642 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701 Query: 2117 SSSASSTLKRT-----KKPRPPSLKKKQ-------TTKKPTETPPVKETQQEPDEESLVP 2164 +A +T K T K+P P + KK TTK+PT T K P + Sbjct: 702 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 761 Query: 2165 SGENLASETKTESAKT-EGPSPALLEE----TPLEPAVGPKAACPLDSESAEGVVP---- 2215 E + K + T +G +P L+E TP +PA PK P ++ Sbjct: 762 PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA--PKELAPTTTKGPTSTTSDKPA 819 Query: 2216 PASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSS 2275 P + +P T P AP E P + E S S D+S+ Sbjct: 820 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS--EVSTPTTTKEPTTIHKSPDEST 877 Query: 2276 WDNQQENPPPTKKIGKK----PVAKMPLR-RPKM------KKTPEKLDNTPASPPRSPAE 2324 + E P + K P K P +P+M K T L TP + +P Sbjct: 878 PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK- 936 Query: 2325 PNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS 2384 + K T T T++ + + Q + DT + KT+ Sbjct: 937 -----MTKETATTT------------EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 979 Query: 2385 SKTP--SSPSKSPASFEIPASAMEANGVDGDGLN------KPAKKKKTPLKTDTFRVKKS 2436 + P ++ K+ + EI E N KP K K P K + K Sbjct: 980 TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS---TKK 1036 Query: 2437 PKRSPLSDPPSQDPTPAATPETPPVIS 2463 PK P P PTP T P ++ Sbjct: 1037 PKTMPRVRKPKTTPTPRKMTSTMPELN 1063 Score = 68.9 bits (167), Expect = 7e-11 Identities = 174/870 (20%), Positives = 267/870 (30%), Gaps = 117/870 (13%) Query: 1365 DAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEK---PVL 1421 D + ET ++ + E + + K+ T+ TS++ T + + I K K P Sbjct: 269 DTSKETSLTVNK--ETTVETKETTTTNKQTSTDGKEKTTSAKE-TQSIEKTSAKDLAPTS 325 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPA--RLQVEKKQQLA 1479 LA P KA + G LT P P P P P K+ Sbjct: 326 KVLAKPTPKAET--TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 383 Query: 1480 GEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVP----PTLREDERPEGPG 1535 + + ++PA PA T + P KE A PT ++ P P Sbjct: 384 TTTKSAPTTPKEPAPTTTKEPAPTTPKE--PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 441 Query: 1536 AAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVER-----AAAFQVAPHSHGEEAVA 1590 P + + P+P + P A + AP + E A Sbjct: 442 KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501 Query: 1591 QDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRST-CAPSPQREVLTVPEANSE 1649 + P+ +E S A T P +T AP+ +E P E Sbjct: 502 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE--PSPTTTKE 559 Query: 1650 PW-TLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGE--VADTPLEPGKVAG--AAGE 1704 P T P A A PAP T + TP EP A Sbjct: 560 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 619 Query: 1705 AEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAAL 1764 +T +T E A + + P T + + P + ++PA Sbjct: 620 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA-------------- 665 Query: 1765 HGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPR 1824 P P+ A P+ P P + ++P EP T + P+ +P Sbjct: 666 ----PTTPKAAAPNT-PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT-----APT 715 Query: 1825 PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSY 1884 P+ PKK AP+ + T+ E + +P P P + +PT Sbjct: 716 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE-PAPTTPKEPA 774 Query: 1885 HGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLS 1944 G T L PA P A ++P+ G S P K+ + Sbjct: 775 PTTPKGTAPTTLK----EPAPT---TPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 827 Query: 1945 RSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPR 2004 ++ E A TP+ P P PPP + P + +P T + P Sbjct: 828 PTTPKEPAPTTPKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 885 Query: 2005 SDSVEGSPFRP---PSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTF---QTLEPRASD 2058 ++E SP P + + +A E A T D T T E + Sbjct: 886 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTT 945 Query: 2059 AKNQEGKVN------TRRKSTDSVP-----ISKSTLSRSLSLQASDFDGASSSGNPEAVA 2107 K E K+ T + D+ P + +TL+ ++ PE A Sbjct: 946 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETA 1005 Query: 2108 LAPDAYSTGSSSASSTLKRTKKPRPPSLKKK----------------------------- 2138 D + ++ K TK P+ P+ KK Sbjct: 1006 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 1065 Query: 2139 --------QTTKKPTETPPVKETQQEPDEE 2160 QTT +P +TP K + P E Sbjct: 1066 SRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1095 Score = 68.2 bits (165), Expect = 1e-10 Identities = 126/605 (20%), Positives = 192/605 (31%), Gaps = 101/605 (16%) Query: 2031 ASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPIS-------KSTL 2083 A SG N DF + DT T Q KV+T K T + PI+ S Sbjct: 222 AGSGLDNGDF-KVTTPDTSTT----------QHNKVSTSPKITTAKPINPRPSLPPNSDT 270 Query: 2084 SRSLSL-----------QASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRP 2132 S+ SL + + + +S+ E A + S +SA +K Sbjct: 271 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 330 Query: 2133 PSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETP 2192 P+ K + TTK P T P + T P E + E + K+ + P+P + P Sbjct: 331 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 390 Query: 2193 LEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVT---PSD 2249 PK P ++ P + P K+ P TT E T P+ Sbjct: 391 ----TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP-TTPKEPAPTTPKKPAP 445 Query: 2250 SGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPE 2309 + +E +P + K + P PT K K P K P Sbjct: 446 TTPKEPAP------------TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP- 492 Query: 2310 KLDNTPASP-PRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYN 2368 TP P P +P EP P ++ +PK P + Sbjct: 493 ---TTPKEPAPTTPKEP----------------------APTTTKEPSPTTPKEPAPTTT 527 Query: 2369 FDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKT 2428 T + P T S + SP + + PA K P T Sbjct: 528 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 587 Query: 2429 DTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTV-- 2486 + + P P ++P P ET P + T EKLA T + T Sbjct: 588 TPKEPAPTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 646 Query: 2487 DLEADKQDYPQPSDLSTFVNET-KFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPK 2543 +L + P P+ T K ++P ++ + P++ PK Sbjct: 647 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP------------KEPAPTTPKEPAPTTPK 694 Query: 2544 KQALYLMFDTSQESPVKSSPVRMSE-------SPTPCSGSSFEETEALVNTAAKNQHPVP 2596 + A +T+ +P ++P + E P P + E T K P Sbjct: 695 EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP 754 Query: 2597 RGLAP 2601 +G AP Sbjct: 755 KGTAP 759 Score = 63.5 bits (153), Expect = 3e-09 Identities = 125/613 (20%), Positives = 206/613 (33%), Gaps = 87/613 (14%) Query: 2051 TLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDF-DGASSSGNPEAVALA 2109 T P + A G T + +T P + +++ + + S S N E+ + Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSS-- 168 Query: 2110 PDAYSTGSSSASSTLKRTKKPRPPSL-------------KKKQTTKKPTETPPVKETQQE 2156 S+ SSS+SST+++ K + + KK +T KKPT PPV + Sbjct: 169 ----SSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD---- 220 Query: 2157 PDEESLVPSGENLAS--ETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVV 2214 + S + +G+ + +T T SP + P + P+ + P +S++++ Sbjct: 221 -EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKP----INPRPSLPPNSDTSK--- 272 Query: 2215 PPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKS 2274 + S V ++ T E E T ++ D K S + E +S Sbjct: 273 ---------ETSLTVNKE-----TTVETKETTTTNKQTSTDGKEKTTSAK------ETQS 312 Query: 2275 SWDNQQENPPPTKKIGKKPV--AKMPLRRPKMKKTPEKLDNTPASP-PRSPAEPNDIPIA 2331 ++ PT K+ KP A+ + P + E TP P +P EP I Sbjct: 313 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 372 Query: 2332 KGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDP-DTCDESVDPFKTSSKTPSS 2390 T P ++T +PK P + +P T + P T P++ Sbjct: 373 SAPTT--------PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 424 Query: 2391 PSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDP 2450 +P + + PA P + T K T K P P +++P Sbjct: 425 TKSAPTTPKEPAPTTPKKPAP----TTPKEPAPTTPKEPTPTTPKEPA------PTTKEP 474 Query: 2451 TPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEAD--KQDYPQPSDLSTFVNET 2508 P E P T ++ A T K T E P P+ + T Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534 Query: 2509 KFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSE 2568 K +PT + + P P T+ + P ++P + Sbjct: 535 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----K 590 Query: 2569 SPTPCSGSSFEET---EALVNTAAKNQHPVPRGLAPNQESHL--QVPEKSSQKELEAMGL 2623 P P + T E T + P+ L P L PEK + E + Sbjct: 591 EPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP 650 Query: 2624 GTPSEAIEITAPE 2636 TP E T E Sbjct: 651 TTPEEPTPTTPEE 663 Score = 53.9 bits (128), Expect = 2e-06 Identities = 146/772 (18%), Positives = 237/772 (30%), Gaps = 99/772 (12%) Query: 8 SDNQRTLSAQTPRSAQPPGN--------SQNIKRKQQDTPGSPDHRDASSIGSVGLGGFC 59 S +T+ + T RS +PP S+ I + + +SS S Sbjct: 123 SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKI 182 Query: 60 TASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPE 119 +S++SA+ +V + +K+ + P PP E + F P+ Sbjct: 183 KSSKNSAANRELQKKLKVKDNKKNRTKKKPT-----PKPPVVDEAGSGLDNGDFKVTTPD 237 Query: 120 GCLASPAAAPEDGPQTQS----PRREPAPNAPGDIAAAFPAERDSSTPYQEIAAV----P 171 T + PR PN+ + ++++ +E Sbjct: 238 TSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS 297 Query: 172 SAGRERQPKEEGQKSSFSFSSGIDQSPGMS----PVPLREPM-KAPLCGEGDQPGGFESQ 226 + G+E+ + + S +S D +P P P E K P +P + Sbjct: 298 TDGKEKTTSAK-ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTT 354 Query: 227 EKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPL-----KPMAPIPQDP 281 KE A P + + S TP+ PA T+S+ K P +P P++P Sbjct: 355 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTT--TKSAPTTPKEPAPTTTKEPAPTTPKEP 412 Query: 282 APRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYL 341 AP + P + A + A + P Sbjct: 413 APTTTKEP----------------------APTTTKSAPTTPKEPAPTTPKKPAPTTPKE 450 Query: 342 PHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGL 401 P P P+P E + KE T + P T P + A P+ Sbjct: 451 PAPTTP-KEPTPTTPKEPAPTTKEPAPTTPKEPAP------TAPKK----PAPTTPKEPA 499 Query: 402 PVSPEPSLLTPTEEAHPASSLASFPAA--QIPIAVEEPGSSSRESVSKAGMPVSADAAKE 459 P +P+ T T+E P + P P +EP ++ +S S KE Sbjct: 500 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 559 Query: 460 VVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLP 519 + + P + PAP+ + T++ P P P P Sbjct: 560 PAPT------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP 613 Query: 520 KEQS------------HEVQPGAPPPPLPKAPSESA-RGPPGPTDGAKVHEDSTSPAVAK 566 KE + ++ P P P P P E A P PT T+P A Sbjct: 614 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 673 Query: 567 EGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRD 626 + KE AP P +P +++ + K L +P+ + Sbjct: 674 PNTPKEPAPTTPKEPAPTTPK--EPAPTTPKETAPTTPK---GTAPTTLKEPAPTTPKKP 728 Query: 627 HPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDP--VLPPVPDGAGEPTVPE 684 P + ++ + D P T + A P + P P P G T+ E Sbjct: 729 APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE 788 Query: 685 GAIWEGSGLQPK--CPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPK 734 A PK P T + + T E + P A PK Sbjct: 789 PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK 840 Score = 48.5 bits (114), Expect = 1e-04 Identities = 132/700 (18%), Positives = 207/700 (29%), Gaps = 153/700 (21%) Query: 266 LEKSPLKPMAPIPQ---DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPE 322 +EK+ K +AP + P P+A +G P+ T P+ + P+ Sbjct: 313 IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT--------PKEPASTTPK 364 Query: 323 AEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRG 382 +P + A P+P A + KE T + P T Sbjct: 365 ------------EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 412 Query: 383 T-----KPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 +P +A P+ P +P+ T +E P + P P +EP Sbjct: 413 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-----PKEPTPTTPKEP 467 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQER 497 +++E P + PAP+ ++ Sbjct: 468 APTTKE--------------------------------------PAPTTPKEPAPTAPKK 489 Query: 498 GEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHE 557 ++ P P P KE S P AP+ + P T A Sbjct: 490 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 549 Query: 558 DSTSPAVAKE-GSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELS 616 SP KE +P + + P P +P ++ ++K+ E + Sbjct: 550 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 609 Query: 617 KPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDG 676 + + P + P K + P T E A P E P P P Sbjct: 610 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE---EPTPTTPEEP-- 664 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQ 736 PT P+ A P+T + E T E + PT E AP Sbjct: 665 --APTTPKAA----------APNTPKEPAPTTPKEPAPTTPKEPA---PTTPKETAPTTP 709 Query: 737 EGESTLEIRKMG------SCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAAD 790 +G + +++ E T+ +P CD P P+G Sbjct: 710 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-------APTTPKGT----- 757 Query: 791 LGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQ 850 P+ P E P ++ K +P+ P+ + LKE A Sbjct: 758 --------------APTTPKE----------PAPTTPK--EPAPTTPKGTAPTTLKEPA- 790 Query: 851 PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTL 910 T+P P K+ +++ P D PT E PK Sbjct: 791 ------PTTPKKPAPKELAPTTTK--GPTSTTSDKPAPT-------TPKETAPTTPKEPA 835 Query: 911 SDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPE 950 TP P E+ SE+S PT K P K P+ Sbjct: 836 PTTP-KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 874 Score = 37.4 bits (85), Expect = 0.22 Identities = 84/379 (22%), Positives = 116/379 (30%), Gaps = 42/379 (11%) Query: 1040 TGEAPPCQPDSVALLDAVPCLPA-LAPASPG-VTPTQDAPETEACDETQEGRQQPVPAPQ 1097 T E P P A P PA P P TP + AP T ++ PAP Sbjct: 471 TKEPAPTTPKEPA--PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPT 525 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQGGEAGAAE---TGGSAGAGDPGKQQAPEKPGEAT 1154 T+ +P S P+ ++ E T A K+ AP P E Sbjct: 526 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 585 Query: 1155 LSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQ 1214 + T E A T+ + + P P+ T + + Sbjct: 586 PT----------TPKEPAPTTTKKPA------------PTTPKEPAPTTPKETAPTTPKK 623 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGA----EDSGVKAVSSADPRAPGESPCP 1270 P E L PE AP TP + + E+ +A P P E Sbjct: 624 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 683 Query: 1271 VGEPPLALENAASLKLFAGSLAPLLQPGAAGGEI--PA-VQASSGSPK--ARTTEGPVDS 1325 + P AP G A + PA +PK A TT S Sbjct: 684 TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 743 Query: 1326 MPCLDRMPLLAKGKQ-ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 C P KG T +E A T P A + +G A E + + P + Sbjct: 744 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 803 Query: 1385 KQGTSGGVDTSSEQIATLT 1403 T G T+S++ A T Sbjct: 804 PTTTKGPTSTTSDKPAPTT 822 Score = 33.1 bits (74), Expect = 4.2 Identities = 179/964 (18%), Positives = 308/964 (31%), Gaps = 80/964 (8%) Query: 415 EAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSD 474 E H +S S A P + + + + ++ P + K+V+++ + E VS+ Sbjct: 106 EVHNPTSPPSSKKAPPPSGASQ---TIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSE 162 Query: 475 LGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPP 534 E + + ++ N+ + E+Q + K ++ + +P PP Sbjct: 163 ---NQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKK-KPTPKPPV 218 Query: 535 LPKAPSESARGP----PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGD 590 + +A S G T + ++ STSP + +P S + + Sbjct: 219 VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 278 Query: 591 PGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQ 650 E + ++ + E + + + +S + S+ P K A T P ++ Sbjct: 279 NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT--PKAE 336 Query: 651 TAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPK--CPDTLQSREGLG 708 T + K E P P P + P P + + PK P T +S Sbjct: 337 TTTKGPALTTPK--EPTPTTPKEP-ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP 393 Query: 709 RMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACD 768 + + T K P TP E AP + + + + E T+P +P Sbjct: 394 KEPAPTTT---KEPAPTTP-KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP----AP 445 Query: 769 ASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEK 828 + +E P P T ++ P+ P E A + P ++ K Sbjct: 446 TTPKEPAPTTPKEPTPTTPKEPAPTT-------KEPAPTTPKEP--APTAPKKPAPTTPK 496 Query: 829 HLQPSQAQPETSIFDVLKEQAQ--PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNN 886 +P+ P+ KE + P E T+ S P + A ++ P P+E + Sbjct: 497 --EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554 Query: 887 LPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGE 946 T E PK TP E + T E APT K PA Sbjct: 555 TTT---------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE-PAPTTTKKPAPTT 604 Query: 947 KRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQ 1006 + +++ +P LA K P ++ EE + Sbjct: 605 PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA------PTTPEELAPTTPEEPTP 658 Query: 1007 H--EEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALA 1064 EE P A+ P + +E A E P P A P Sbjct: 659 TTPEEPAPTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTL 717 Query: 1065 PASPGVTPTQDAPETEACDETQEGRQQPV--PAPQQKMECWATSDAESPKLLASFPSAGE 1122 TP + AP+ A T+E PAP T+ E P+ Sbjct: 718 KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTT 777 Query: 1123 QGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEH--CLTSGEEASTSALRES 1180 G A T A K+ AP++ T T T+ +E + + +E Sbjct: 778 P---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 834 Query: 1181 CQA--EHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAA------ 1232 + P + + P P +T + +T PD LS P A Sbjct: 835 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 894 Query: 1233 -PDTPYLHVDSAAQ----RGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLF 1287 P P +A + A+D + P +P E E K+ Sbjct: 895 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT 954 Query: 1288 AGS--LAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEE 1345 A + + +I ++ ++ +PK TT+ + + +++ AK K Sbjct: 955 ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS 1014 Query: 1346 KAAT 1349 KA T Sbjct: 1015 KATT 1018 >gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f [Homo sapiens] Length = 1412 Score = 88.6 bits (218), Expect = 8e-17 Identities = 282/1341 (21%), Positives = 441/1341 (32%), Gaps = 272/1341 (20%) Query: 1265 GESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVD 1324 G+SP EP A S GS+ P A G + A QA S S D Sbjct: 154 GKSPRKSAEPS-ANTTLVSETEEEGSV-PAFGAAAKPGMVSAGQADSSSE---------D 202 Query: 1325 SMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDP 1384 + D + K + + +AA+AP G G A S + G+P +D Sbjct: 203 TSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDS 262 Query: 1385 KQGTSGGVDTSSE--------QIATLTGFPDFREHIAKIFEKPVLGALATPGEKAG--AG 1434 + + D+ E Q A E P GA P K G Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322 Query: 1435 RSAVGK-------------------DLTRPLG--PEKLLDGPPGVDVT---LLPAPP--- 1467 ++ GK +P G P+ P + PAPP Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT 382 Query: 1468 ----ARLQVEKKQQLA------GEAEISHLALQDPASDKLLGPAGLTWERNLPGAG-VGK 1516 A++QV K+++ + +++ LA + A K LG + + G G +GK Sbjct: 383 GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK 442 Query: 1517 EMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAA 1576 VPP P W E + S E S +P+ A + Sbjct: 443 GAGPVPPGKVGPATPSAQVGKW---EEDSESSSEESSDSSDGEVPTAVAPAQ-EKSLGNI 498 Query: 1577 FQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSP 1636 Q P S + Q P Q + D+ + D A + P + A + Sbjct: 499 LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS---EEAPAAMTA-AQ 554 Query: 1637 QREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPG 1696 + L +P+ + P +T + V G R A G ++PA + VA P Sbjct: 555 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAGGTQRPA 613 Query: 1697 KVAGAAGEAEGD-----ITLSTAETQACASGDLPEAGTTRTFSVVAGDL------VLPGS 1745 + + ++ E++ + + ++ + ++ G +A + V G L VLPG Sbjct: 614 EDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASV----PVKGSLGQGTAPVLPGK 669 Query: 1746 CQDPACSDKAPGMEGTAALHGDSPA--------------RPQQAKEQPGPERPIPAGDGK 1791 KA E + + +S + + QAK P R P+ G Sbjct: 670 TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAAR-APSAKGT 728 Query: 1792 VCVSSPPEPDETHDPKLQHLAPEELHTDRESPR------PGPSMLPSVPKKDAPRVMDKV 1845 + S P T + + +P ++ +P+ GP+ +PSV K A + Sbjct: 729 I---SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 785 Query: 1846 TSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAA 1905 +E G+ ES ++ E+ TLA G Q+ L SP Sbjct: 786 GPEEDSGSSEEESD------------SEEEAETLAQVKPSGK-THQIRAALAPAKESPRK 832 Query: 1906 AHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAP 1965 A PP + PS K S SEE+ E+ P Sbjct: 833 GAAPTPPG-----------------KTGPSAAQAGKQDDSGSSSEESDSDGEA--PAAVT 873 Query: 1966 PAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFD 2025 A PP + +P S P P PR S R S S D Sbjct: 874 SAQVIKPPLIFVDPNRS----PAGPAATPAQAQAASTPRKARASESTARSSS---SESED 926 Query: 2026 EDK-PIASSGTYNLDFDNIELVDTFQTLEPRA--------------SDAKNQEG-KVNTR 2069 ED P T + + + + + P+A SD K QEG Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986 Query: 2070 RKSTDSVPISKSTLSRSLSLQASDFD-----GASSSGNPEAVALAPDAYSTGSSSASSTL 2124 +K+ S+P++++ L + L+ +AS+ SSG AV P +T S S Sbjct: 987 KKNPASLPLTQAAL-KVLAQKASEAQPPVARTQPSSGVDSAVGTLP---ATSPQSTSVQA 1042 Query: 2125 KRTKKPRPPSLKKKQTTKKPTETPPVKETQQE----PDEESLVPSG-------------- 2166 K T K R P L + Q K E+ E + +E+ P G Sbjct: 1043 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSR 1102 Query: 2167 -ENLASETKTESAKTE--GPSPALLE--ETP-LEPA--VGPKAACPLDS----------- 2207 E L ET ES++ + PS +LL TP L PA KA LDS Sbjct: 1103 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAK 1162 Query: 2208 -----------ESAEGVVPPASGGGRVQN--SPPVGRKTLPLTTAPEA------------ 2242 + A G++ P +GG + +P RK P+A Sbjct: 1163 DDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQC 1222 Query: 2243 --GEVTPSDSGGQEDSPAKGLSVRLEFDYSE--------DKSSWDNQQENPPPTKKIGKK 2292 G+ P + + S K L+ LE + + + W++++ K G + Sbjct: 1223 LLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKR-----KLSGDQ 1277 Query: 2293 PVAKMPLRRPKMK----------KTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKW 2342 P A+ P + K K +PEK T + D+ KG + Sbjct: 1278 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL----- 1332 Query: 2343 DDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPA 2402 + ++ P+ Q + D+S K K K E Sbjct: 1333 ---------GSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1383 Query: 2403 SAMEANGVDGDGLNKPAKKKK 2423 A +A+ D + ++ KKKK Sbjct: 1384 KAKKASTKDSESPSQKKKKKK 1404 Score = 75.5 bits (184), Expect = 7e-13 Identities = 262/1220 (21%), Positives = 408/1220 (33%), Gaps = 246/1220 (20%) Query: 316 NSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGH 375 ++ + E E A ++ + P A + L LPS ++ +A ++A T + H Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPS-SMKEKAKAETEKAGKTGNSMPH 141 Query: 376 PQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIP--IA 433 P TG V + +G P S +L++ TEE S+ +F AA P ++ Sbjct: 142 PATG------KTVANLLSGKSPRKSAEPSANTTLVSETEEE---GSVPAFGAAAKPGMVS 192 Query: 434 VEEPGSSSRESVSKAG-MPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVP-- 490 + SSS ++ S + V A+++++ + + P G G V Sbjct: 193 AGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 252 Query: 491 --APSPQERGEHLNTEQS--HEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESAR-G 545 A P+E E + E S E P K Q GA P ++P + A Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 312 Query: 546 PPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 PPG T PAVAK + GK E EDSQ+ S + Sbjct: 313 PPG----------KTGPAVAK--------AQAGKRE---------------EDSQSSSEE 339 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGE 665 D E +KPS A S+ + + PRKG A P +T A A K E Sbjct: 340 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---PAPPRKTGPAAAQVQVGKQEE 396 Query: 666 EDPVLPPVPDGAGEPTVPEGAIWE---GSGLQPKCPDTLQSREGLGRMESFLTLESEKSD 722 + D E A G Q K T+ G+G + Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM----GMGPLGKGAGPVPPGKV 452 Query: 723 FPPTPVAEVAPKAQEGESTLEIRKMGSCDGE-GLLTSPDQPRGPACDASRQEFHAGVPHP 781 P TP A+V ++ ES+ E S DGE +P Q + + + P Sbjct: 453 GPATPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP 511 Query: 782 PQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPET-- 839 PQ A +D + S + E P + +P+ P+T Sbjct: 512 PQKAGPVAVQVKAEKPMDNSESSEESSDS-----ADSEEAPAAMTAAQAKPALKIPQTKA 566 Query: 840 -----------SIFDVLKEQAQPPENGKETSP--SHP----GFKDQGADSSQIHVPVEPQ 882 + V P + G TSP S P G + DSS + Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626 Query: 883 EDNNLPTHGGQEQALGSELQ---------SQLPKGTLSDTP-TSSPTDMVWESSLTEESE 932 E L GQ +++G LQ L +GT P + PT ++ E+SE Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686 Query: 933 LS-----------APTRQK-----------------------LPALGEKRPEGACGDGQS 958 S +P + K + A G+ A +S Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 746 Query: 959 -SRVSPPAADVLKDFSLAGNFSR-----KETCCTGQGPNKSQQALADALEEGSQHEEA-- 1010 S+V PP + LA + K Q ++ + EE EEA Sbjct: 747 PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAET 806 Query: 1011 -CQRHP--------------------GASEAADG-CSPLWGLSKREMASGNTGEAPPCQP 1048 Q P GA+ G P + ++ SG++ E Sbjct: 807 LAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 866 Query: 1049 DSVALLDAVPCL--------PALAPASPGVTPTQ----------DAPETEACDETQEGRQ 1090 ++ A + + + P +PA P TP Q A E+ A + E Sbjct: 867 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 926 Query: 1091 QPV-PAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEK 1149 + V PA Q T+ P + P + AGA+ + S+ D KQ+ P Sbjct: 927 EDVIPATQCLTPGIRTNVVTMP---TAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 983 Query: 1150 PGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMD 1209 L T+ L +++ +A+ P+A Q + +G +P ++ Sbjct: 984 QVSKKNPASLPLTQAAL-------KVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQ 1036 Query: 1210 FSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESP- 1268 ++ QA G ++ P P + + A ++DS + SS+ GE P Sbjct: 1037 STSVQA---------KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1087 Query: 1269 ------CPVGEPPLALEN---------------AASLKLFAGSLAPLLQPGAAGGEIPAV 1307 VG P E A S L +G + P L P + Sbjct: 1088 GAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS------- 1140 Query: 1308 QASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAA 1367 QAS +PK +DS P + LA G+++A AG + G A+ Sbjct: 1141 QASKATPK-------LDSSPSVS--STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS 1191 Query: 1368 GETEGSMERMGEPSQDPKQG 1387 G T + S+ PK+G Sbjct: 1192 GTTP-------QKSRKPKKG 1204 Score = 74.7 bits (182), Expect = 1e-12 Identities = 270/1291 (20%), Positives = 419/1291 (32%), Gaps = 259/1291 (20%) Query: 14 LSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASE-SSASLDPCL 72 LS ++PR + P + + + ++ P A+ G V G ++SE +S+S D Sbjct: 152 LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211 Query: 73 V----SPEVTEPRKDPQGARGPEGS-LLPSPP--------------PSQEREHPS--SSM 111 V S ++ + R A+G G P+PP P ++ E S SS Sbjct: 212 VEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 271 Query: 112 PFAECPPEGCLASPAAAPE-------DGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPY 164 E P L A+ + P +SPR+ AP PG A Sbjct: 272 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA----------- 320 Query: 165 QEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFE 224 A AG+ +EE +SS S +++P + + KAP P E Sbjct: 321 ---VAKAQAGK----REEDSQSSSEESDSEEEAPAQA----KPSGKAPQVRAASAPAK-E 368 Query: 225 SQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESS------AVLEKSPLKPMAPIP 278 S K AA PP ++ A VQV + + ES A + + +KP+ P Sbjct: 369 SPRKGAAPA-PPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 427 Query: 279 Q-DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEV-------NAASQ 330 Q PA G+G P P A P A+V ++S+ Sbjct: 428 QVKPASTMGMGPLGKGAGPVP--------------PGKVGPATPSAQVGKWEEDSESSSE 473 Query: 331 ESCQQPVG----AYLPHAELPWG---LPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGT 383 ES G A P E G P P G K + VQ + M + Sbjct: 474 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG--PVAVQVKAEKPMDNS 531 Query: 384 KPNQVVCVAAGGQ--PEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAV------- 434 + ++ +A + P +P+L P +A P + + A P+ V Sbjct: 532 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 591 Query: 435 ---------------------EEPGSSSRESVS---KAGMPVSADAAKEVVDAGLVGLER 470 E SSS ES S K G+ V+ AK V GL+ Sbjct: 592 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK----GLQV 647 Query: 471 QVSDLGSKGEHPEGD----PGEVPAPSPQERGEHL----NTEQSHEVQPGVPPPPLPKEQ 522 + + + KG +G PG+ Q + E ++E+ + + P K Sbjct: 648 KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTS 707 Query: 523 SHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEA 582 + Q A P ++ PG A SP+ K R+P +S Sbjct: 708 VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 767 Query: 583 PEPPDGGDPGNLQG-------EDSQAFSSKRDPEVGKDELS--KPSSD--------AESR 625 P G EDS + + D E + L+ KPS A ++ Sbjct: 768 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 827 Query: 626 DHPSSHSA-QPPRKGG-----AGHTDGPHSQTAEADASG-LPHKLGEEDPVLPPV--PDG 676 + P +A PP K G AG D S + E+D+ G P + + PP+ D Sbjct: 828 ESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDP 887 Query: 677 AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDF------------- 723 P P A P ++ E R S ESE D Sbjct: 888 NRSPAGP--AATPAQAQAASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRT 942 Query: 724 ----PPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVP 779 PT +APKA ++ DG+ + GPA S++ Sbjct: 943 NVVTMPTAHPRIAPKASMAGASSSKESSRISDGK-------KQEGPATQVSKK------- 988 Query: 780 HPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPET 839 +P A L + A + Q + + A P S P + Sbjct: 989 NPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATS------PQSTSVQA 1042 Query: 840 SIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGS 899 + L++ P +P + +DSS GS Sbjct: 1043 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS-----------------------GS 1079 Query: 900 ELQSQLPKGTLSD----TPTSSPTDMVWESSLTEESE--LSAPTRQKLPALGEKRPEGAC 953 E + P+G S PT S T+ + E + E SE + AP++ L G P Sbjct: 1080 EEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLS--GYMTPGLTP 1137 Query: 954 GDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQR 1013 + Q+S+ +P L + S T P+ Q+A + Q Sbjct: 1138 ANSQASKATP---------KLDSSPSVSSTLAAKDDPDGKQEA------KPQQAAGMLSP 1182 Query: 1014 HPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGV--- 1070 G EAA G +P ++ A Q + L P A V Sbjct: 1183 KTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKV 1242 Query: 1071 -TPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAG- 1128 T + + D T+E ++ + ++K+ A +P+ +GGEA Sbjct: 1243 LTELLEQERKKVVDTTKESSRKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEASV 1301 Query: 1129 ----AAETGGSAGAGDPGKQQAPEKPGEATL 1155 + T D EK G+ +L Sbjct: 1302 SPEKTSTTSKGKAKRDKASGDVKEKKGKGSL 1332 Score = 61.6 bits (148), Expect = 1e-08 Identities = 241/1217 (19%), Positives = 397/1217 (32%), Gaps = 207/1217 (17%) Query: 1550 ERSRQELASGLPSPAATQ------ELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQET 1603 E + E A P A+T +LP + G+ + +GK Sbjct: 92 EEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANL 151 Query: 1604 SACDSPHGEDGPGD----FAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGE 1659 + SP P + T G VP A P +++SE + + + Sbjct: 152 LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211 Query: 1660 RRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQAC 1719 + IL++R A S PA T TP PGK A + + +E+ + Sbjct: 212 VEVKASEKILQVRAA----SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE 267 Query: 1720 ASGDLPE---AGTTRTFSVVAGDLVLPGSCQDPA-------CSDKAPGMEGTAALHGDSP 1769 S D E A + +G G+ PA + PG G A + Sbjct: 268 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 327 Query: 1770 ARPQQAK----------EQPGPERP-----------IPAGDGKVCVSSPPEPDETHDPKL 1808 R + ++ E P +P PA + ++P P +T Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 387 Query: 1809 QHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAE-------GTESSPV 1861 Q ++ R S S ++ +A +V S + + A G + PV Sbjct: 388 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 447 Query: 1862 ADDIIQPAAPA--------DLESPTLAAS-SYHGDVVGQV------STDLIAQSISPAAA 1906 + PA P+ D ES + +S S G+V V S I Q+ P ++ Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-KPTSS 506 Query: 1907 HAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPP 1966 A PP A P +V+A P D ++ SSDS ++ E P + T +A P Sbjct: 507 PAKGPPQKA-------GPVAVQVKAEKPM--DNSESSEESSDSADSEEAPAAMTAAQAKP 557 Query: 1967 APPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDE 2026 A P + P+ +T ++ PV G ++ G+ P S + Sbjct: 558 ALKIPQTKACPKKTNTT--------ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT 609 Query: 2027 DKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNT------------------ 2068 +P S + E T+ S K + K + Sbjct: 610 QRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 669 Query: 2069 RRKSTDSVPISKSTLSRSLSLQASDFDGASSS--------------GNPEAVALAPDAYS 2114 + V K S S S + SD + A++S NP A A AP A Sbjct: 670 TGPTVTQVKAEKQEDSES-SEEESDSEEAAASPAQVKTSVKKTQAKANP-AAARAPSAKG 727 Query: 2115 TGSS-------SASSTLKRTKKPRPPSLKKKQTT---KKPTETPPV-------KETQQEP 2157 T S+ +A + + K +PP + +T + P P V + Q P Sbjct: 728 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787 Query: 2158 DEESLVPSGENLASETKTESAKTEGPSP---------ALLEETPLEPAV-------GPKA 2201 +E+S S E SE + E+ PS A +E+P + A GP A Sbjct: 788 EEDS-GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 846 Query: 2202 A---------CPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGG 2252 A + ++G P A +V P + P P+ + Sbjct: 847 AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI-------FVDPNRSPAGPAATPA 899 Query: 2253 QEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIG---KKPVAKMPLRRPKMKKTPE 2309 Q + + R + SS ++ P T+ + + V MP P++ Sbjct: 900 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP--- 956 Query: 2310 KLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNF 2369 K AS + + +D +G T K NP S L Q++ Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKK------NPASLPLTQAALKVLAQKASEA 1010 Query: 2370 DPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTD 2429 P ++T S A +PA++ ++ V G NK K K ++ Sbjct: 1011 QPPV-----------ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1059 Query: 2430 TFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE 2489 T + S SD S P+ +V T + + E Sbjct: 1060 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEE------TAAE 1113 Query: 2490 ADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDD-------AP 2542 + + D PS T +P + + +++ + S+L DD P Sbjct: 1114 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1173 Query: 2543 KKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVN--TAAKNQHPVPRGLA 2600 ++ A L T + + + S P +G+ T AL + T P P A Sbjct: 1174 QQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1233 Query: 2601 PNQESHLQVPEKSSQKE 2617 Q S ++V + ++E Sbjct: 1234 QVQASVVKVLTELLEQE 1250 Score = 48.1 bits (113), Expect = 1e-04 Identities = 149/749 (19%), Positives = 252/749 (33%), Gaps = 141/749 (18%) Query: 4 ENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGG-FCTAS 62 E+S S + + S + +A P + +K Q R S+ G++ G TA+ Sbjct: 683 EDSESSEEESDSEE---AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 739 Query: 63 ESSASLDPCLVSPEVTEPRKDPQGARGP-----------------EGSLLPSPPPSQERE 105 + P V P V P+ ARGP G S +E + Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799 Query: 106 HPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPG------------DIAAA 153 + A+ P G AA P +SPR+ AP PG D + + Sbjct: 800 SEEEAETLAQVKPSGKTHQIRAAL--APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGS 857 Query: 154 FPAERDS-------------------------------STPYQEIAAVPSAGRERQPKEE 182 E DS +TP Q AA S R+ + E Sbjct: 858 SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA--STPRKARASES 915 Query: 183 GQKSSFSFSSGIDQSPG---MSP--------VPLREPM---KAPLCGEGDQPGGFESQEK 228 +SS S S D P ++P +P P KA + G + Sbjct: 916 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 975 Query: 229 EAAGGFPPAESRQGVASVQVTPEA-PAAAQQGTESSAVLEKSPL-----KPMAPIPQDPA 282 + G S++ AS+ +T A AQ+ +E+ + ++ + +P Sbjct: 976 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSP 1035 Query: 283 PRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLP 342 S + +G + L E +A P S+ + ++ ++ S+E + P GA Sbjct: 1036 QSTSVQAKGTNKLRKPKLP---EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1092 Query: 343 HAEL-PWGLPSPALVPEAGGSGKE-----------------ALDTIDVQGHPQTGMRGTK 384 H + P + LV E E L + Q T + Sbjct: 1093 HTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1152 Query: 385 PNQVVCVAAGGQPEGGLPVSPEPS--LLTPTEEAHPASSLASFPAAQIP-IAVEEPGSSS 441 P+ +AA P+G P+ + +L+P A+S + ++ P P +S+ Sbjct: 1153 PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAST 1212 Query: 442 RESVSK-----AGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQE 496 S G P + A+ V A +V + ++ L + + E + Sbjct: 1213 LALQSNITQCLLGQPWPLNEAQ--VQASVVKVLTEL--LEQERKKVVDTTKESSRKGWES 1268 Query: 497 RGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVH 556 R L+ +Q P P K++ G P+ S +++G K Sbjct: 1269 RKRKLSGDQ-----PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKG--------KAK 1315 Query: 557 EDSTSPAVAKEGSRSPGDSPGGKEEAPE-------PPDGGDPGNLQGEDSQAFSSKRDPE 609 D S V ++ + S G K+E E +GGD N + + + S KR + Sbjct: 1316 RDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKD 1375 Query: 610 VGKDELSKPSSDAESRDHPSSHSAQPPRK 638 K E K + A ++D S + +K Sbjct: 1376 KEKKEKKKKAKKASTKDSESPSQKKKKKK 1404 >gi|226437579 NAC alpha domain containing [Homo sapiens] Length = 1562 Score = 86.7 bits (213), Expect = 3e-16 Identities = 314/1426 (22%), Positives = 471/1426 (33%), Gaps = 211/1426 (14%) Query: 60 TASESSASLDPCLVSPEVT-----EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFA 114 T + A+L+P +V E T PR R EG PP + S+P Sbjct: 107 TEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSP 166 Query: 115 ECPPEGCLASP--------AAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSS---TP 163 P+ P A P GP + R+ ++ + PA S Sbjct: 167 PPDPDSFFTPPSTPTKTTYALLPACGPHGDA--RDSEAELRDELLDSPPASPSGSYITAD 224 Query: 164 YQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGF 223 A+ PS EG F SG SP S V RE A G + P Sbjct: 225 GDSWASSPSCSLSLLAPAEG----LDFPSGWGLSPQGSMVDERELHPA---GTPEPPSSE 277 Query: 224 ESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQ--QGT-----ESSAVLEKSPLKPMAP 276 S +++ + + + P PAA QG+ E+ V SP + Sbjct: 278 SSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEE 337 Query: 277 IPQDPAPRASDRERGQGEAPPQYLTDDL------EFLRACHLPRSNSGAAPEAEVNAASQ 330 DP P G+ ++ L E + R ++ AA +A+ Sbjct: 338 AVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYA 397 Query: 331 ESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTID------VQGHPQTGMRGTK 384 E+ + + + PHA+ S E G G + L D V+ PQT RG Sbjct: 398 EADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAY 457 Query: 385 PNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVE-EPGSSSRE 443 +Q + + EG + +TP +L P Q+ +A P + E Sbjct: 458 LSQRQELISEVTEEGLALGQESTATVTP-------HTLQVAPGLQVEVATRVTPQAGEEE 510 Query: 444 SVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAP-SPQERGEHLN 502 + S AG +A A + G+ + Q S K P+ + P SPQ E Sbjct: 511 TDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGG 570 Query: 503 TEQSHEVQPGVPPPPLPKEQSHEV---QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDS 559 + +P +P++ ++ Q A PPLP ++ + P P A + Sbjct: 571 LDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQ 629 Query: 560 TSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPS 619 A+EG P DS PP L +D++ SS P +S+ + Sbjct: 630 -----AEEGLTLPQDS------VMTPP-------LPLQDTE-LSSAPKPVAAATLVSQQA 670 Query: 620 SDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGE 679 + + S+ + P + TD + A A+ L + EE LP D A Sbjct: 671 EEGLTLPQDSAMTPPLPLQD----TDLSSAPKPVAAAT-LVSQQAEEGLTLPQ--DSAMT 723 Query: 680 PTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEV----APKA 735 P +P S +P TL S++ E LTL + + PP P+ + APK Sbjct: 724 PPLPLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMTPPLPLQDTDLSSAPKP 779 Query: 736 QEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTA 795 + + + EGL D P + + P P + + Sbjct: 780 VAAATIVSQQAE-----EGLTLPQDSAMTPPLPLQDTDL-SSAPKPVAAATIVSQQAEEG 833 Query: 796 LILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENG 855 L L QD P P L ++ P T + +E P++ Sbjct: 834 LTLPQDSAMTPPLP-------------LQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDS 880 Query: 856 KETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDT-P 914 T P Q D S PV + G S + + LP L DT P Sbjct: 881 AMTPP----LPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLP---LQDTGP 933 Query: 915 TSSPTDMVWESSLTEESELS-APTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFS 973 TS P + + T ++E AP + + + ++ A G P A K+ + Sbjct: 934 TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG--------PRPAPEEKNAA 985 Query: 974 LAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHP-GASEAADGCSPLWGLSK 1032 L P + A D +++ A P A E AD + LS Sbjct: 986 L---------------PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSL 1030 Query: 1033 REMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQP 1092 E ASG E ++++ CL A A G P ET + QEG +P Sbjct: 1031 PEPASGAGEEIA----EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKP 1086 Query: 1093 VPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGE 1152 + + A+ P + + A E G +G P E Sbjct: 1087 LAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP----------E 1136 Query: 1153 ATLSCGLLQTEHCLTSGEEAS---TSALRESCQAEHPMASCQDALLPARELGGIPRSTMD 1209 TL + TE L S E+S S+L C S + P LG Sbjct: 1137 PTLP-SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLG-----LGS 1190 Query: 1210 FSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPC 1269 VP L PPE A P VD G A ++ P P +PC Sbjct: 1191 VEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEP-PAPC 1249 Query: 1270 PVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSG-------------SPKA 1316 +P E++ + GSL L P AG + PA A SG SP + Sbjct: 1250 LCQDPQ---EDSVEDEEPPGSLG--LPPPQAGVQ-PAAAAVSGTTQPLGTGPRVSLSPHS 1303 Query: 1317 RTTEGPVDSMPCLD-RMPLL-------AKGKQATGEEKAATAPGA----------GAKAS 1358 V SM D + +L G Q+ + +AP +A Sbjct: 1304 PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL 1363 Query: 1359 GEGMAGDAAGETEGSMERMG----EPSQDPKQGTSGGVDTSSEQIA 1400 G G D+ GE+ ++ + Q P Q +GG S E IA Sbjct: 1364 GSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGG---SEETIA 1406 Score = 53.9 bits (128), Expect = 2e-06 Identities = 328/1550 (21%), Positives = 524/1550 (33%), Gaps = 269/1550 (17%) Query: 547 PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNL---QGEDSQAFS 603 PGP+ A S A + S PGG A P G P + +G SQA S Sbjct: 47 PGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALS 106 Query: 604 SKRD-PEVGKDELSKPSSDAESRDHP-SSHSAQPPRKGGAGHTDGPHSQTAEADASGLPH 661 ++ P + + ++ P ++ +A ++GG D P ++ D S Sbjct: 107 TEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSV--- 163 Query: 662 KLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKS 721 P PP PD P P L P C +R+ S L E Sbjct: 164 ------PSPPPDPDSFFTP--PSTPTKTTYALLPACGPHGDARD------SEAELRDELL 209 Query: 722 DFPPTPVAEVAPKAQEGES-----TLEIRKMGSCDGEGLLTSPD----QPRGPACDASRQ 772 D PP + A +G+S + + + +G L P P+G D + Sbjct: 210 DSPPASPSGSYITA-DGDSWASSPSCSLSLLAPAEG---LDFPSGWGLSPQGSMVD--ER 263 Query: 773 EFH-AGVPHPPQGEN-LAADL----GLTALILDQD----QQGIPSC--PGEGWI--RGAA 818 E H AG P PP E+ L+AD G D D IP+ P +G + + A Sbjct: 264 ELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA 323 Query: 819 SEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGK-----------ETSPSHPGFKD 867 E LS E+ + + A P+ D+ E + + E F+D Sbjct: 324 VEVTPLSPEEEEEEAVADPDPG-GDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRD 382 Query: 868 QGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPK----------------GTLS 911 + +S E ++ + G+ A + LQ + K GT+S Sbjct: 383 DTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS 442 Query: 912 DTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQ----------SSRV 961 ++P + L++ EL + ++ ALG++ ++RV Sbjct: 443 WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRV 502 Query: 962 SPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEAC---QRHPGAS 1018 +P A + D S AG S P SQ+ +++ L + S E Q + Sbjct: 503 TPQAGEEETD-STAGQESAAMAM-----PQPSQEGISEILGQESVTAEKLPTPQEETSLT 556 Query: 1019 EAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLD-AVPCLPALAPASP------GVT 1071 D L ++ SG A A D +P A+ P P Sbjct: 557 LCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSA 616 Query: 1072 PTQDAPETEACDETQEGRQQP---VPAPQQKMECWATSDAESPKLLASFPSAGEQGG--- 1125 P A T + +EG P V P ++ S A P A+ S + G Sbjct: 617 PKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTL 676 Query: 1126 -------------EAGAAETGGSAGAGDPGKQQAPEK---PGEATLSCGLLQTEHCLTSG 1169 + + A QQA E P ++ ++ L + L+S Sbjct: 677 PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 736 Query: 1170 EEASTSALRESCQAEHPMASCQDAL------LPARELGGIPR-----STMDFSTHQAVPD 1218 + +A S QAE + QD+ L +L P+ + + + + Sbjct: 737 PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796 Query: 1219 PKELLLSGP-----PEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAP------GES 1267 P++ ++ P ++++ P +Q+ E + S+ P P + Sbjct: 797 PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856 Query: 1268 PCPVGEP-PLALENAASLKLFAGSLA----PLLQPGAAGGEIPAVQASSGSPKARTTEG- 1321 P PV P++ + L L S PL + P A+ S +A EG Sbjct: 857 PKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE--EGL 914 Query: 1322 --PVDS-----MPCLDRMPL-----LAKGKQATGEEKAATAPGAGAKAS-GEGMAGDAAG 1368 P DS +P D P LA T + +A APG A+ + G+A G Sbjct: 915 TLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG 974 Query: 1369 ETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLG--ALAT 1426 E+ P+ V Q A G P + A LG AL+ Sbjct: 975 PRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD----STLGMEALSL 1030 Query: 1427 PGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPAR--LQVEKKQQ------- 1477 P +GAG + + L+RP G E L+ P P + L+VE +Q+ Sbjct: 1031 PEPASGAGEE-IAEALSRP-GREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1088 Query: 1478 --------LAGEAEISHL---ALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLR 1526 L G E+ A + + +LL PA ER L G + PTL Sbjct: 1089 QEHGPRSALGGAREVPDAPPAACPEVSQARLLSPA--REERGLSGKSTPE------PTLP 1140 Query: 1527 EDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGE 1586 E + P A S L+R + + +P + Q PV + + H Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVE---QPHEV 1197 Query: 1587 EAVAQDRIPSGKQH----QETSACDSPHGED--GPGDFAHTGVPGHVPRSTC-APSPQRE 1639 +V + ++ Q ++ D P G D PG A +P P + C PQ + Sbjct: 1198 PSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQED 1257 Query: 1640 VLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVA 1699 + E P +L P AG+ A+ + P V+ +P P Sbjct: 1258 SV---EDEEPPGSLGL------PPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSP 1308 Query: 1700 GAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGME 1759 A D+ L +LP CQ P S G + Sbjct: 1309 KVASMDAKDLALQ----------------------------ILP-PCQVPPPS----GPQ 1335 Query: 1760 GTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTD 1819 A G S Q+ ++ + P G G+ S E + + LAP+ + Sbjct: 1336 SPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDI--LAPQTVQCP 1393 Query: 1820 RESPRPGPSMLPSVPK-----KDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADL 1874 ++P G + K K A + M K+ + +G + + A P Sbjct: 1394 AQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVF 1453 Query: 1875 ESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAP 1924 +SP A+ +Y V G+ + ++Q + AAA PS +V SAP Sbjct: 1454 KSP--ASDTYV--VFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAP 1499 Score = 43.9 bits (102), Expect = 0.002 Identities = 156/706 (22%), Positives = 252/706 (35%), Gaps = 99/706 (14%) Query: 1660 RRPGVTAGILEMRNALGNQSTPA--PPTGEVADTPLEPG-------KVAGAAGEAEGDIT 1710 +R + + + E ALG +ST P T +VA PG +V AGE E D T Sbjct: 460 QRQELISEVTEEGLALGQESTATVTPHTLQVA-----PGLQVEVATRVTPQAGEEETDST 514 Query: 1711 LSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPA 1770 E+ A A + G + Q+ ++K P + +L P Sbjct: 515 AGQ-ESAAMAMPQPSQEGISEILG------------QESVTAEKLPTPQEETSLTL-CPD 560 Query: 1771 RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSML 1830 PQ KE+ G + +P+G V ++ + A E+L ++S P L Sbjct: 561 SPQNLKEEGGLD--LPSGRKPVAAATI----------VPRQAKEDLTLPQDSAMTPPLPL 608 Query: 1831 PSVPKKDAPRVMDKVTSDETRGAEG---------TESSPVADDIIQPAAPADLESPTLAA 1881 AP+ + T + EG T P+ D + +AP + + TL + Sbjct: 609 QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELS-SAPKPVAAATLVS 667 Query: 1882 S-SYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAG---DRVEASTPSCP 1937 + G + Q S + + P AA +VS A G + A TP P Sbjct: 668 QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727 Query: 1938 DPAKDLSR-----------SSDSEEAFETPES---TTPVKAPPAPPPPPPEVIPEPEVST 1983 DLS S +EE P+ T P+ P+ + + + Sbjct: 728 LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVS 787 Query: 1984 QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHS--FSAVFDEDKPIASSGTYNLDFD 2041 Q E ++ P P D+ S +P + + S +E + Sbjct: 788 QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT---P 844 Query: 2042 NIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSG 2101 + L DT + P+ A V+ + + ++P S ++ L LQ +D A Sbjct: 845 PLPLQDTDLSSAPKPVAAATP---VSQQAEEGLTLP-QDSAMTPPLPLQDTDLSSA---- 896 Query: 2102 NPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEES 2161 P+ VA A S + + + + P L+ T P E V Q E Sbjct: 897 -PKPVAAATPV-SQQAEEGLTLPQDSAMTAPLPLQDTGPTSGP-EPLAVATPQTLQAEAG 953 Query: 2162 LVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGG 2221 P E +A+ + E + GP PA E+ P V AA LD + P A G Sbjct: 954 CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAA--LDQVQQDDPQPAAEAG- 1010 Query: 2222 RVQNSPPVGRKTLPLTTAPEAGEV-TPSDSGGQEDSPA---KGLSVRLEF-DYSEDKSSW 2276 +P ++ T EA + P+ G+E + A G LE ++ D + Sbjct: 1011 ----TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKP 1066 Query: 2277 DNQQENP---PPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPP 2319 D+ Q+ ++ G KP+A+ R + E D PA+ P Sbjct: 1067 DSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1112 Score = 42.4 bits (98), Expect = 0.007 Identities = 225/1104 (20%), Positives = 368/1104 (33%), Gaps = 174/1104 (15%) Query: 1634 PSPQREVLTVPEANSEPW-------TLDTLGGERRPGVTAGILEMRNAL-----GNQSTP 1681 P P ++ +S W LD L + P + A +L + +L + TP Sbjct: 271 PEPPSSESSLSADSSSSWGQEGHFFDLDFLAND--PMIPAALLPFQGSLIFQVEAVEVTP 328 Query: 1682 APPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLV 1741 P E + +P AGE E D T S + Q+ + + E G F+ D Sbjct: 329 LSPEEEEEEAVADPDPGGDLAGEGEEDST-SASFLQSLSDLSITE-GMDEAFA-FRDDTS 385 Query: 1742 LPGSCQDPACSDKAPG-------MEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKV-- 1792 S D A +A A L DS + ++ E G + + A DG V Sbjct: 386 AASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEE--ESGGGAKGLQAQDGTVSW 443 Query: 1793 CVSSPPEPDE------THDPKLQHLAPEELHTDRESPRPGP----SMLPSVPKKDAPRVM 1842 V + P+ + + + E L +ES + P + + A RV Sbjct: 444 AVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVT 503 Query: 1843 DKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSIS 1902 + +ET G ES+ +A + P+ S +++GQ S Sbjct: 504 PQAGEEETDSTAGQESAAMA-----------MPQPSQEGIS---EILGQESVTAEKLPTP 549 Query: 1903 PAAAHAGLPPSAAEHIVSPSA---PAGDRVEASTPSCPDPAK-DLSRSSDSEEAFETPES 1958 L P + +++ P+G + A+ P AK DL+ DS P Sbjct: 550 QEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQ 609 Query: 1959 TTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSH 2018 T + + P P + + +Q E ++V P P D+ S +P + Sbjct: 610 DTDLSSAPKP-------VAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662 Query: 2019 S--FSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSV 2076 + S +E + + L DT + P+ A V+ + + ++ Sbjct: 663 ATLVSQQAEEGLTLPQDSAMT---PPLPLQDTDLSSAPKPVAAAT---LVSQQAEEGLTL 716 Query: 2077 PISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPP-SL 2135 P S ++ L LQ +D A P+ VA A + + TL + PP L Sbjct: 717 P-QDSAMTPPLPLQDTDLSSA-----PKPVAAA--TLVSQQAEEGLTLPQDSAMTPPLPL 768 Query: 2136 KKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEP 2195 + + P Q+ +E +P +SA T P L++T L Sbjct: 769 QDTDLSSAPKPVAAATIVSQQAEEGLTLPQ----------DSAMT---PPLPLQDTDLSS 815 Query: 2196 AVGPKAACPLDSESA-EGVVPPASGGGRVQNSPPVGRKTLPLTTAP-------------E 2241 A P AA + S+ A EG+ P +PP+ + L++AP E Sbjct: 816 APKPVAAATIVSQQAEEGLTLPQDSA----MTPPLPLQDTDLSSAPKPVAAATPVSQQAE 871 Query: 2242 AGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRR 2301 G P DS P + + ++ +QQ T A +PL+ Sbjct: 872 EGLTLPQDSAMTPPLPLQDTDLS-SAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQD 930 Query: 2302 PKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTF---DIDKWDDPNFNPFSSTSKMQ- 2357 PE L A+P AE P + T ++ + P P + + Sbjct: 931 TGPTSGPEPL--AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPT 988 Query: 2358 -ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLN 2416 P Q DP E+ P+ S+ S PAS A + L+ Sbjct: 989 VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASG--AGEEIAEALS 1046 Query: 2417 KPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAV 2476 +P ++ + T A P++P + V E L Sbjct: 1047 RPGREACLEARAHT--------------------GDGAKPDSPQKETLEVENQQEGGLKP 1086 Query: 2477 TNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLP 2536 Q+ + L ++ P V++ + SP E G S P Sbjct: 1087 LAQEHGPRSA-LGGAREVPDAPPAACPEVSQARLLSPAR----------EERGLSGKSTP 1135 Query: 2537 QDDDAPKKQALYLMFDTSQES---PVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQ- 2592 + P A D+ ES V S ++P P S + ++ E ++ + Q Sbjct: 1136 -EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQP 1194 Query: 2593 HPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA-- 2650 H VP L LQ PE + G PS ++ P G SA L+ A Sbjct: 1195 HEVPSVLG---TPLLQPPEN--------LAKGQPSTPVD--RPLGPDPSAPGTLAGAALP 1241 Query: 2651 --HPVSLCGALDYLEPDLAEKNPP 2672 P + C D E + ++ PP Sbjct: 1242 PLEPPAPCLCQDPQEDSVEDEEPP 1265 >gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens] Length = 1562 Score = 86.7 bits (213), Expect = 3e-16 Identities = 314/1426 (22%), Positives = 471/1426 (33%), Gaps = 211/1426 (14%) Query: 60 TASESSASLDPCLVSPEVT-----EPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFA 114 T + A+L+P +V E T PR R EG PP + S+P Sbjct: 107 TEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSP 166 Query: 115 ECPPEGCLASP--------AAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSS---TP 163 P+ P A P GP + R+ ++ + PA S Sbjct: 167 PPDPDSFFTPPSTPTKTTYALLPACGPHGDA--RDSEAELRDELLDSPPASPSGSYITAD 224 Query: 164 YQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGF 223 A+ PS EG F SG SP S V RE A G + P Sbjct: 225 GDSWASSPSCSLSLLAPAEG----LDFPSGWGLSPQGSMVDERELHPA---GTPEPPSSE 277 Query: 224 ESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQ--QGT-----ESSAVLEKSPLKPMAP 276 S +++ + + + P PAA QG+ E+ V SP + Sbjct: 278 SSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEE 337 Query: 277 IPQDPAPRASDRERGQGEAPPQYLTDDL------EFLRACHLPRSNSGAAPEAEVNAASQ 330 DP P G+ ++ L E + R ++ AA +A+ Sbjct: 338 AVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYA 397 Query: 331 ESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTID------VQGHPQTGMRGTK 384 E+ + + + PHA+ S E G G + L D V+ PQT RG Sbjct: 398 EADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAY 457 Query: 385 PNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVE-EPGSSSRE 443 +Q + + EG + +TP +L P Q+ +A P + E Sbjct: 458 LSQRQELISEVTEEGLALGQESTATVTP-------HTLQVAPGLQVEVATRVTPQAGEEE 510 Query: 444 SVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAP-SPQERGEHLN 502 + S AG +A A + G+ + Q S K P+ + P SPQ E Sbjct: 511 TDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGG 570 Query: 503 TEQSHEVQPGVPPPPLPKEQSHEV---QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDS 559 + +P +P++ ++ Q A PPLP ++ + P P A + Sbjct: 571 LDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQ 629 Query: 560 TSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPS 619 A+EG P DS PP L +D++ SS P +S+ + Sbjct: 630 -----AEEGLTLPQDS------VMTPP-------LPLQDTE-LSSAPKPVAAATLVSQQA 670 Query: 620 SDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGE 679 + + S+ + P + TD + A A+ L + EE LP D A Sbjct: 671 EEGLTLPQDSAMTPPLPLQD----TDLSSAPKPVAAAT-LVSQQAEEGLTLPQ--DSAMT 723 Query: 680 PTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEV----APKA 735 P +P S +P TL S++ E LTL + + PP P+ + APK Sbjct: 724 PPLPLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMTPPLPLQDTDLSSAPKP 779 Query: 736 QEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTA 795 + + + EGL D P + + P P + + Sbjct: 780 VAAATIVSQQAE-----EGLTLPQDSAMTPPLPLQDTDL-SSAPKPVAAATIVSQQAEEG 833 Query: 796 LILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENG 855 L L QD P P L ++ P T + +E P++ Sbjct: 834 LTLPQDSAMTPPLP-------------LQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDS 880 Query: 856 KETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDT-P 914 T P Q D S PV + G S + + LP L DT P Sbjct: 881 AMTPP----LPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLP---LQDTGP 933 Query: 915 TSSPTDMVWESSLTEESELS-APTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFS 973 TS P + + T ++E AP + + + ++ A G P A K+ + Sbjct: 934 TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG--------PRPAPEEKNAA 985 Query: 974 LAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHP-GASEAADGCSPLWGLSK 1032 L P + A D +++ A P A E AD + LS Sbjct: 986 L---------------PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSL 1030 Query: 1033 REMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQP 1092 E ASG E ++++ CL A A G P ET + QEG +P Sbjct: 1031 PEPASGAGEEIA----EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKP 1086 Query: 1093 VPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGE 1152 + + A+ P + + A E G +G P E Sbjct: 1087 LAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP----------E 1136 Query: 1153 ATLSCGLLQTEHCLTSGEEAS---TSALRESCQAEHPMASCQDALLPARELGGIPRSTMD 1209 TL + TE L S E+S S+L C S + P LG Sbjct: 1137 PTLP-SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLG-----LGS 1190 Query: 1210 FSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPC 1269 VP L PPE A P VD G A ++ P P +PC Sbjct: 1191 VEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEP-PAPC 1249 Query: 1270 PVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSG-------------SPKA 1316 +P E++ + GSL L P AG + PA A SG SP + Sbjct: 1250 LCQDPQ---EDSVEDEEPPGSLG--LPPPQAGVQ-PAAAAVSGTTQPLGTGPRVSLSPHS 1303 Query: 1317 RTTEGPVDSMPCLD-RMPLL-------AKGKQATGEEKAATAPGA----------GAKAS 1358 V SM D + +L G Q+ + +AP +A Sbjct: 1304 PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL 1363 Query: 1359 GEGMAGDAAGETEGSMERMG----EPSQDPKQGTSGGVDTSSEQIA 1400 G G D+ GE+ ++ + Q P Q +GG S E IA Sbjct: 1364 GSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGG---SEETIA 1406 Score = 53.9 bits (128), Expect = 2e-06 Identities = 328/1550 (21%), Positives = 524/1550 (33%), Gaps = 269/1550 (17%) Query: 547 PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNL---QGEDSQAFS 603 PGP+ A S A + S PGG A P G P + +G SQA S Sbjct: 47 PGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALS 106 Query: 604 SKRD-PEVGKDELSKPSSDAESRDHP-SSHSAQPPRKGGAGHTDGPHSQTAEADASGLPH 661 ++ P + + ++ P ++ +A ++GG D P ++ D S Sbjct: 107 TEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSV--- 163 Query: 662 KLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKS 721 P PP PD P P L P C +R+ S L E Sbjct: 164 ------PSPPPDPDSFFTP--PSTPTKTTYALLPACGPHGDARD------SEAELRDELL 209 Query: 722 DFPPTPVAEVAPKAQEGES-----TLEIRKMGSCDGEGLLTSPD----QPRGPACDASRQ 772 D PP + A +G+S + + + +G L P P+G D + Sbjct: 210 DSPPASPSGSYITA-DGDSWASSPSCSLSLLAPAEG---LDFPSGWGLSPQGSMVD--ER 263 Query: 773 EFH-AGVPHPPQGEN-LAADL----GLTALILDQD----QQGIPSC--PGEGWI--RGAA 818 E H AG P PP E+ L+AD G D D IP+ P +G + + A Sbjct: 264 ELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA 323 Query: 819 SEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGK-----------ETSPSHPGFKD 867 E LS E+ + + A P+ D+ E + + E F+D Sbjct: 324 VEVTPLSPEEEEEEAVADPDPG-GDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRD 382 Query: 868 QGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPK----------------GTLS 911 + +S E ++ + G+ A + LQ + K GT+S Sbjct: 383 DTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS 442 Query: 912 DTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQ----------SSRV 961 ++P + L++ EL + ++ ALG++ ++RV Sbjct: 443 WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRV 502 Query: 962 SPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEAC---QRHPGAS 1018 +P A + D S AG S P SQ+ +++ L + S E Q + Sbjct: 503 TPQAGEEETD-STAGQESAAMAM-----PQPSQEGISEILGQESVTAEKLPTPQEETSLT 556 Query: 1019 EAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLD-AVPCLPALAPASP------GVT 1071 D L ++ SG A A D +P A+ P P Sbjct: 557 LCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSA 616 Query: 1072 PTQDAPETEACDETQEGRQQP---VPAPQQKMECWATSDAESPKLLASFPSAGEQGG--- 1125 P A T + +EG P V P ++ S A P A+ S + G Sbjct: 617 PKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTL 676 Query: 1126 -------------EAGAAETGGSAGAGDPGKQQAPEK---PGEATLSCGLLQTEHCLTSG 1169 + + A QQA E P ++ ++ L + L+S Sbjct: 677 PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 736 Query: 1170 EEASTSALRESCQAEHPMASCQDAL------LPARELGGIPR-----STMDFSTHQAVPD 1218 + +A S QAE + QD+ L +L P+ + + + + Sbjct: 737 PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796 Query: 1219 PKELLLSGP-----PEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAP------GES 1267 P++ ++ P ++++ P +Q+ E + S+ P P + Sbjct: 797 PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856 Query: 1268 PCPVGEP-PLALENAASLKLFAGSLA----PLLQPGAAGGEIPAVQASSGSPKARTTEG- 1321 P PV P++ + L L S PL + P A+ S +A EG Sbjct: 857 PKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE--EGL 914 Query: 1322 --PVDS-----MPCLDRMPL-----LAKGKQATGEEKAATAPGAGAKAS-GEGMAGDAAG 1368 P DS +P D P LA T + +A APG A+ + G+A G Sbjct: 915 TLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG 974 Query: 1369 ETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLG--ALAT 1426 E+ P+ V Q A G P + A LG AL+ Sbjct: 975 PRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD----STLGMEALSL 1030 Query: 1427 PGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPAR--LQVEKKQQ------- 1477 P +GAG + + L+RP G E L+ P P + L+VE +Q+ Sbjct: 1031 PEPASGAGEE-IAEALSRP-GREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1088 Query: 1478 --------LAGEAEISHL---ALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLR 1526 L G E+ A + + +LL PA ER L G + PTL Sbjct: 1089 QEHGPRSALGGAREVPDAPPAACPEVSQARLLSPA--REERGLSGKSTPE------PTLP 1140 Query: 1527 EDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGE 1586 E + P A S L+R + + +P + Q PV + + H Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVE---QPHEV 1197 Query: 1587 EAVAQDRIPSGKQH----QETSACDSPHGED--GPGDFAHTGVPGHVPRSTC-APSPQRE 1639 +V + ++ Q ++ D P G D PG A +P P + C PQ + Sbjct: 1198 PSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQED 1257 Query: 1640 VLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVA 1699 + E P +L P AG+ A+ + P V+ +P P Sbjct: 1258 SV---EDEEPPGSLGL------PPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSP 1308 Query: 1700 GAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGME 1759 A D+ L +LP CQ P S G + Sbjct: 1309 KVASMDAKDLALQ----------------------------ILP-PCQVPPPS----GPQ 1335 Query: 1760 GTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTD 1819 A G S Q+ ++ + P G G+ S E + + LAP+ + Sbjct: 1336 SPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDI--LAPQTVQCP 1393 Query: 1820 RESPRPGPSMLPSVPK-----KDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADL 1874 ++P G + K K A + M K+ + +G + + A P Sbjct: 1394 AQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVF 1453 Query: 1875 ESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAP 1924 +SP A+ +Y V G+ + ++Q + AAA PS +V SAP Sbjct: 1454 KSP--ASDTYV--VFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAP 1499 Score = 43.9 bits (102), Expect = 0.002 Identities = 156/706 (22%), Positives = 252/706 (35%), Gaps = 99/706 (14%) Query: 1660 RRPGVTAGILEMRNALGNQSTPA--PPTGEVADTPLEPG-------KVAGAAGEAEGDIT 1710 +R + + + E ALG +ST P T +VA PG +V AGE E D T Sbjct: 460 QRQELISEVTEEGLALGQESTATVTPHTLQVA-----PGLQVEVATRVTPQAGEEETDST 514 Query: 1711 LSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPA 1770 E+ A A + G + Q+ ++K P + +L P Sbjct: 515 AGQ-ESAAMAMPQPSQEGISEILG------------QESVTAEKLPTPQEETSLTL-CPD 560 Query: 1771 RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSML 1830 PQ KE+ G + +P+G V ++ + A E+L ++S P L Sbjct: 561 SPQNLKEEGGLD--LPSGRKPVAAATI----------VPRQAKEDLTLPQDSAMTPPLPL 608 Query: 1831 PSVPKKDAPRVMDKVTSDETRGAEG---------TESSPVADDIIQPAAPADLESPTLAA 1881 AP+ + T + EG T P+ D + +AP + + TL + Sbjct: 609 QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELS-SAPKPVAAATLVS 667 Query: 1882 S-SYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAG---DRVEASTPSCP 1937 + G + Q S + + P AA +VS A G + A TP P Sbjct: 668 QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727 Query: 1938 DPAKDLSR-----------SSDSEEAFETPES---TTPVKAPPAPPPPPPEVIPEPEVST 1983 DLS S +EE P+ T P+ P+ + + + Sbjct: 728 LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVS 787 Query: 1984 QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHS--FSAVFDEDKPIASSGTYNLDFD 2041 Q E ++ P P D+ S +P + + S +E + Sbjct: 788 QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT---P 844 Query: 2042 NIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSG 2101 + L DT + P+ A V+ + + ++P S ++ L LQ +D A Sbjct: 845 PLPLQDTDLSSAPKPVAAATP---VSQQAEEGLTLP-QDSAMTPPLPLQDTDLSSA---- 896 Query: 2102 NPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEES 2161 P+ VA A S + + + + P L+ T P E V Q E Sbjct: 897 -PKPVAAATPV-SQQAEEGLTLPQDSAMTAPLPLQDTGPTSGP-EPLAVATPQTLQAEAG 953 Query: 2162 LVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGG 2221 P E +A+ + E + GP PA E+ P V AA LD + P A G Sbjct: 954 CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAA--LDQVQQDDPQPAAEAG- 1010 Query: 2222 RVQNSPPVGRKTLPLTTAPEAGEV-TPSDSGGQEDSPA---KGLSVRLEF-DYSEDKSSW 2276 +P ++ T EA + P+ G+E + A G LE ++ D + Sbjct: 1011 ----TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKP 1066 Query: 2277 DNQQENP---PPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPP 2319 D+ Q+ ++ G KP+A+ R + E D PA+ P Sbjct: 1067 DSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1112 Score = 42.4 bits (98), Expect = 0.007 Identities = 225/1104 (20%), Positives = 368/1104 (33%), Gaps = 174/1104 (15%) Query: 1634 PSPQREVLTVPEANSEPW-------TLDTLGGERRPGVTAGILEMRNAL-----GNQSTP 1681 P P ++ +S W LD L + P + A +L + +L + TP Sbjct: 271 PEPPSSESSLSADSSSSWGQEGHFFDLDFLAND--PMIPAALLPFQGSLIFQVEAVEVTP 328 Query: 1682 APPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLV 1741 P E + +P AGE E D T S + Q+ + + E G F+ D Sbjct: 329 LSPEEEEEEAVADPDPGGDLAGEGEEDST-SASFLQSLSDLSITE-GMDEAFA-FRDDTS 385 Query: 1742 LPGSCQDPACSDKAPG-------MEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKV-- 1792 S D A +A A L DS + ++ E G + + A DG V Sbjct: 386 AASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEE--ESGGGAKGLQAQDGTVSW 443 Query: 1793 CVSSPPEPDE------THDPKLQHLAPEELHTDRESPRPGP----SMLPSVPKKDAPRVM 1842 V + P+ + + + E L +ES + P + + A RV Sbjct: 444 AVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVT 503 Query: 1843 DKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSIS 1902 + +ET G ES+ +A + P+ S +++GQ S Sbjct: 504 PQAGEEETDSTAGQESAAMA-----------MPQPSQEGIS---EILGQESVTAEKLPTP 549 Query: 1903 PAAAHAGLPPSAAEHIVSPSA---PAGDRVEASTPSCPDPAK-DLSRSSDSEEAFETPES 1958 L P + +++ P+G + A+ P AK DL+ DS P Sbjct: 550 QEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQ 609 Query: 1959 TTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSH 2018 T + + P P + + +Q E ++V P P D+ S +P + Sbjct: 610 DTDLSSAPKP-------VAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662 Query: 2019 S--FSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSV 2076 + S +E + + L DT + P+ A V+ + + ++ Sbjct: 663 ATLVSQQAEEGLTLPQDSAMT---PPLPLQDTDLSSAPKPVAAAT---LVSQQAEEGLTL 716 Query: 2077 PISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPP-SL 2135 P S ++ L LQ +D A P+ VA A + + TL + PP L Sbjct: 717 P-QDSAMTPPLPLQDTDLSSA-----PKPVAAA--TLVSQQAEEGLTLPQDSAMTPPLPL 768 Query: 2136 KKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEP 2195 + + P Q+ +E +P +SA T P L++T L Sbjct: 769 QDTDLSSAPKPVAAATIVSQQAEEGLTLPQ----------DSAMT---PPLPLQDTDLSS 815 Query: 2196 AVGPKAACPLDSESA-EGVVPPASGGGRVQNSPPVGRKTLPLTTAP-------------E 2241 A P AA + S+ A EG+ P +PP+ + L++AP E Sbjct: 816 APKPVAAATIVSQQAEEGLTLPQDSA----MTPPLPLQDTDLSSAPKPVAAATPVSQQAE 871 Query: 2242 AGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRR 2301 G P DS P + + ++ +QQ T A +PL+ Sbjct: 872 EGLTLPQDSAMTPPLPLQDTDLS-SAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQD 930 Query: 2302 PKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTF---DIDKWDDPNFNPFSSTSKMQ- 2357 PE L A+P AE P + T ++ + P P + + Sbjct: 931 TGPTSGPEPL--AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPT 988 Query: 2358 -ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLN 2416 P Q DP E+ P+ S+ S PAS A + L+ Sbjct: 989 VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASG--AGEEIAEALS 1046 Query: 2417 KPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAV 2476 +P ++ + T A P++P + V E L Sbjct: 1047 RPGREACLEARAHT--------------------GDGAKPDSPQKETLEVENQQEGGLKP 1086 Query: 2477 TNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLP 2536 Q+ + L ++ P V++ + SP E G S P Sbjct: 1087 LAQEHGPRSA-LGGAREVPDAPPAACPEVSQARLLSPAR----------EERGLSGKSTP 1135 Query: 2537 QDDDAPKKQALYLMFDTSQES---PVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQ- 2592 + P A D+ ES V S ++P P S + ++ E ++ + Q Sbjct: 1136 -EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQP 1194 Query: 2593 HPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA-- 2650 H VP L LQ PE + G PS ++ P G SA L+ A Sbjct: 1195 HEVPSVLG---TPLLQPPEN--------LAKGQPSTPVD--RPLGPDPSAPGTLAGAALP 1241 Query: 2651 --HPVSLCGALDYLEPDLAEKNPP 2672 P + C D E + ++ PP Sbjct: 1242 PLEPPAPCLCQDPQEDSVEDEEPP 1265 >gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo sapiens] Length = 1450 Score = 85.1 bits (209), Expect = 9e-16 Identities = 267/1330 (20%), Positives = 433/1330 (32%), Gaps = 234/1330 (17%) Query: 1247 GAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPA 1306 G DS + SS+ E V + + ++ + A AP PG G P Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA--PGKVGDVTPQ 251 Query: 1307 VQASSGSPKART------TEGPVDSMPCLDRMPLLAKGKQATGEE----KAATAPGAGAK 1356 V+ + P R +E + + P + + E+ +AA+AP G Sbjct: 252 VKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP 311 Query: 1357 ASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSE--------QIATLTGFPDF 1408 G A S + G+P +D + + D+ E Q Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371 Query: 1409 REHIAKIFEKPVLGALATPGEKAG--AGRSAVGK-------------------DLTRPLG 1447 A E P GA P K G ++ GK +P G Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431 Query: 1448 --PEKLLDGPPGVDVT---LLPAPP-------ARLQVEKKQQLA------GEAEISHLAL 1489 P+ P + PAPP A++QV K+++ + +++ LA Sbjct: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 1490 QDPASDKLLGPAGLTWERNLPGAG-VGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQ 1548 + A K LG + + G G +GK VPP P W E + S Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW---EEDSESS 548 Query: 1549 LERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDS 1608 E S +P+ A + Q P S + Q P Q + D+ Sbjct: 549 SEESSDSSDGEVPTAVAPAQ-EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDN 607 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 + D A + P + A + + L +P+ + P +T + V G Sbjct: 608 SESSEESSDSADS---EEAPAAMTA-AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGT 663 Query: 1669 LEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGD-----ITLSTAETQACASGD 1723 R A G ++PA + VA P + + ++ E++ + + ++ + ++ G Sbjct: 664 QAPRKA-GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722 Query: 1724 LPEAGTTRTFSVVAGDL------VLPGSCQDPACSDKAPGMEGTAALHGDSPA------- 1770 +A + V G L VLPG KA E + + +S + Sbjct: 723 QVKAASV----PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778 Query: 1771 -------RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP 1823 + QAK P R P+ G + S P T + + +P ++ +P Sbjct: 779 AQVKTSVKKTQAKANPAAAR-APSAKGTI---SAPGKVVTAAAQAKQRSPSKVKPPVRNP 834 Query: 1824 R------PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESP 1877 + GP+ +PSV K A + +E G+ ES ++ E+ Sbjct: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD------------SEEEAE 882 Query: 1878 TLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCP 1937 TLA G Q+ L SP A PP + PS Sbjct: 883 TLAQVKPSGK-THQIRAALAPAKESPRKGAAPTPPG-----------------KTGPSAA 924 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 K S SEE+ E+ P A PP + +P S P P Sbjct: 925 QAGKQDDSGSSSEESDSDGEA--PAAVTSAQVIKPPLIFVDPNRS----PAGPAATPAQA 978 Query: 1998 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDK-PIASSGTYNLDFDNIELVDTFQTLEPRA 2056 PR S R S S DED P T + + + + + P+A Sbjct: 979 QAASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKA 1035 Query: 2057 --------------SDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGN 2102 SD K QEG + ++P +T +S S+QA + Sbjct: 1036 SMAGASSSKESSRISDGKKQEGPATQVDSAVGTLP---ATSPQSTSVQAKGTNKLRKPKL 1092 Query: 2103 PEA--VALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPP---VKETQQEP 2157 PE AP++ S+ S+ + P K T PT + V+ET E Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES 1152 Query: 2158 DEESLVPSGENLASETKTESAKTEGPSPALLEETPLE--PAVGPKAACPLD--------S 2207 E+ +V ++L S T T S A L+ P+V A D Sbjct: 1153 SEDDVVAPSQSLLSGYMTPGL-TPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1211 Query: 2208 ESAEGVVPPASGGGRVQN--SPPVGRKTLPLTTAPEA--------------GEVTPSDSG 2251 + A G++ P +GG + +P RK P+A G+ P + Sbjct: 1212 QQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1271 Query: 2252 GQEDSPAKGLSVRLEFDYSE--------DKSSWDNQQENPPPTKKIGKKPVAKMPLRRPK 2303 + S K L+ LE + + + W++++ K G +P A+ P + K Sbjct: 1272 QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKR-----KLSGDQPAARTPRSKKK 1326 Query: 2304 MK----------KTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSST 2353 K +PEK T + D+ KG + + Sbjct: 1327 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL--------------GS 1372 Query: 2354 SKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGD 2413 ++ P+ Q + D+S K K K E A +A+ D + Sbjct: 1373 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSE 1432 Query: 2414 GLNKPAKKKK 2423 ++ KKKK Sbjct: 1433 SPSQKKKKKK 1442 Score = 76.6 bits (187), Expect = 3e-13 Identities = 277/1250 (22%), Positives = 413/1250 (33%), Gaps = 213/1250 (17%) Query: 251 EAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDD-LEFLR 308 EA A + T A S L P +A + G+ G + P T + L Sbjct: 93 EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLL 152 Query: 309 ACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALD 368 + PR + A P A S+ + V A+ A+ G+ S + + D Sbjct: 153 SGKSPRKS--AEPSANTTLVSETEEEGSVPAFGAAAKP--GMVSAGQADSSSEDTSSSSD 208 Query: 369 TIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLL---TPTEE--AHPASSLA 423 DV+G P KP QV + + +P P + TP + A P + A Sbjct: 209 ETDVEGKPSV-----KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263 Query: 424 SFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPE 483 P + + E GS S E + AG A+++++ + + P Sbjct: 264 KKPEEESESS--EEGSESEEE-APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320 Query: 484 GDPGEVP----APSPQERGEHLNTEQS--HEVQPGVPPPPLPKEQSHEVQPGAPPPPLPK 537 G G V A P+E E + E S E P K Q GA P + Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380 Query: 538 APSESAR-GPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQG 596 +P + A PPG T PAVAK + GK E Sbjct: 381 SPRKGAAPAPPG----------KTGPAVAK--------AQAGKRE--------------- 407 Query: 597 EDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADA 656 EDSQ+ S + D E +KPS A S+ + + PRKG A P +T A A Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---PAPPRKTGPAAA 464 Query: 657 SGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWE---GSGLQPKCPDTLQSREGLGRMESF 713 K E+ D E A G Q K T+ G+G + Sbjct: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM----GMGPLGKG 520 Query: 714 LTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGE-GLLTSPDQPRGPACDASRQ 772 P TP A+V ++ ES+ E S DGE +P Q + + Sbjct: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 773 EFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQP 832 + PPQ A +D + S + E P + +P Sbjct: 580 PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-----ADSEEAPAAMTAAQAKP 634 Query: 833 SQAQPET-------------SIFDVLKEQAQPPENGKETSP--SHP----GFKDQGADSS 873 + P+T + V P + G TSP S P G + DSS Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694 Query: 874 QIHVPVEPQEDNNLPTHGGQEQALGSELQ---------SQLPKGTLSDTP-TSSPTDMVW 923 +E L GQ +++G LQ L +GT P + PT Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754 Query: 924 ESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKET 983 ++ E+SE S A ++ +P AA + S G S Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA---RAPSAKGTIS---- 807 Query: 984 CCTGQGPNKSQQALADALEEGSQHEEACQRHP-GASEAADGCSPLWGLSKR--------- 1033 P K A A A + + R+P ++ A G + + + K Sbjct: 808 -----APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 862 Query: 1034 --EMASGNTGEAPPCQPDSVALLDAVP------CLPALAPA--SP--GVTPTQDAPETEA 1081 E SG++ E + ++ L P ALAPA SP G PT P Sbjct: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT--PPGKTG 920 Query: 1082 CDETQEGRQQPVPAPQQKMECWATSDAESPKLLAS-------FPSAGEQGGEAGAAETGG 1134 Q G+Q + ++ + SD E+P + S AG A T Sbjct: 921 PSAAQAGKQDDSGSSSEESD----SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPA 976 Query: 1135 SA-GAGDPGKQQAPEKPGEATLSCG----LLQTEHCLTSGEEASTSALRESCQAEHPMAS 1189 A A P K +A E ++ S ++ CLT G + + + P AS Sbjct: 977 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036 Query: 1190 CQDALLPARELGGI--------PRSTMDFST---HQAVPDPKELLLSGPPEVAAPDTPYL 1238 A ++E I P + +D + P + G ++ P P + Sbjct: 1037 MAGA-SSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEV 1095 Query: 1239 HVDSAAQRGAEDSGVKAVSSADPRAPGE-----------SPCPVGEPPLALENAA----- 1282 + A ++DS + SS+ GE P P L E AA Sbjct: 1096 QQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSED 1155 Query: 1283 -----SLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAK 1337 S L +G + P L P + QAS +PK +DS P + LA Sbjct: 1156 DVVAPSQSLLSGYMTPGLTPANS-------QASKATPK-------LDSSPSVS--STLAA 1199 Query: 1338 GKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 G+++A AG + G A+G T + S+ PK+G Sbjct: 1200 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTP-------QKSRKPKKG 1242 Score = 74.3 bits (181), Expect = 2e-12 Identities = 246/1169 (21%), Positives = 376/1169 (32%), Gaps = 194/1169 (16%) Query: 8 SDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSAS 67 S N L A P S + ++ K T S H + L G + S Sbjct: 107 STNSSVLGADLPSSMKEKAKAET--EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164 Query: 68 LDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLA-SPA 126 + LVS E GA G + S + SSS E EG + PA Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSS---DETDVEGKPSVKPA 221 Query: 127 AAPEDGPQT-QSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQK 185 T +SP R+ AP APG + TP + A+P A R ++P+EE + Sbjct: 222 QVKASSVSTKESPARKAAP-APGKVGDV--------TPQVKGGALPPAKRAKKPEEESES 272 Query: 186 SSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVAS 245 S G ES+E+ AG ++ + + Sbjct: 273 SE---------------------------------EGSESEEEAPAGTRSQVKASEKILQ 299 Query: 246 VQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLE 305 V+ A +A +GT P K A Q A + + E+ + +D E Sbjct: 300 VR----AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSESSSEESSDSEE 351 Query: 306 FLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKE 365 A + ++V AAS + + P P P G PA+ G +E Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP---APPGKTGPAVAKAQAGKREE 408 Query: 366 ALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP---VSPEPSLLTPTEEAHPASSL 422 + + + A +P G P + P+ +P + A PA Sbjct: 409 DSQSSSEESDSEEE-----------APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457 Query: 423 ASFP-AAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH 481 + P AAQ+ + +E SR S ++ A AA +G QV + G Sbjct: 458 KTGPAAAQVQVGKQE--EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG 515 Query: 482 PEG------DPGEVPAPSPQ------ERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPG 529 P G PG+V +P E ++E+S + G P + Q + Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575 Query: 530 APPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGG 589 P S A+GPP V + P E S DS EEAP Sbjct: 576 LQAKP----TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-ADSEEAPAAMTA- 629 Query: 590 DPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHS 649 +QA + + P+ K K ++ A ++ P Q PRK G T S Sbjct: 630 ---------AQAKPALKIPQT-KACPKKTNTTASAKVAPVRVGTQAPRKAGTA-TSPAGS 678 Query: 650 QTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGR 709 A A + P + + G A G GLQ K ++ + LG+ Sbjct: 679 SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAA-SVPVKGSLGQ 737 Query: 710 MESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDA 769 T PT A K ++ ES+ E D E SP Q + + Sbjct: 738 G----TAPVLPGKTGPTVTQVKAEKQEDSESSEE-----ESDSEEAAASPAQVK-TSVKK 787 Query: 770 SRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPS-------CPGEGWI--RGAASE 820 ++ + + P + + G Q +Q PS P + RG AS Sbjct: 788 TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV 847 Query: 821 WPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVE 880 + + +Q PE +E++ E + + P K + QI + Sbjct: 848 PSVGKAVATAAQAQTGPEED-SGSSEEESDSEEEAETLAQVKPSGK-----THQIRAALA 901 Query: 881 PQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQK 940 P +++ P G G S G D+ +SS EES+ Sbjct: 902 PAKES--PRKGAAPTPPGKTGPSAAQAGKQDDSGSSS-----------EESDSDG----- 943 Query: 941 LPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADA 1000 E + + PP V + S AG + P K++ + + A Sbjct: 944 ---------EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTA 994 Query: 1001 LEEGSQHEE-----ACQ---------------RHPGASEAADGCSPLWGLSKREMASGNT 1040 S+ E+ A Q HP + A ++ G Sbjct: 995 RSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKK 1054 Query: 1041 GEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKM 1100 E P Q DS AV LPA +P S V T + R+ +P QQ Sbjct: 1055 QEGPATQVDS-----AVGTLPATSPQSTSV----------QAKGTNKLRKPKLPEVQQAT 1099 Query: 1101 ECWATSDAESPKLLASFPSAGEQGGEAGA 1129 + +SD +S S + G GA Sbjct: 1100 KAPESSDDSEDSSDSSSGSEEDGEGPQGA 1128 Score = 68.2 bits (165), Expect = 1e-10 Identities = 203/962 (21%), Positives = 326/962 (33%), Gaps = 195/962 (20%) Query: 1529 ERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEA 1588 E P A PG G Q++ A P E E + + + AP + Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291 Query: 1589 VAQDRIPSGKQHQETSACDSPHGEDGPGDF-AHTGVPGHVPRSTCAPSPQREVLTVPEAN 1647 A ++I Q +A G G G A G G V T A P+ + + E + Sbjct: 292 KASEKIL-----QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346 Query: 1648 SEPWTLDTLGGERRPGVTAGILEMR-----NALGNQSTPAPPTGEVADTPLEPGKVAGAA 1702 S+ E +L+ + + +G S PA + P PGK A Sbjct: 347 SD--------SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398 Query: 1703 GEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTA 1762 +A+ +++ + S EA P + S KAP + + Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEA---------------PAQAKP---SGKAPQVRAAS 440 Query: 1763 ALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRES 1822 A +SP + P P R +V V E + + EE +DRE+ Sbjct: 441 APAKESPRKGAA----PAPPRKTGPAAAQVQVGKQEEDSRS--------SSEESDSDREA 488 Query: 1823 PRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPA--------DL 1874 + P +P+V K S G G + PV + PA P+ D Sbjct: 489 -LAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545 Query: 1875 ESPTLAAS-SYHGDVVGQV------STDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGD 1927 ES + +S S G+V V S I Q+ P ++ A PP A P Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-KPTSSPAKGPPQKA-------GPVAV 597 Query: 1928 RVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPP 1987 +V+A P D ++ SSDS ++ E P + T +A PA P + P+ +T Sbjct: 598 QVKAEKPM--DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT---- 651 Query: 1988 EEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 2047 ++ PV G ++ G+ P S P + GT Sbjct: 652 ----ASAKVAPVRVGTQAPRKAGTATSPAGSS---------PAVAGGT------------ 686 Query: 2048 TFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS-TLSRSLSLQASDFDGASSSGNPEAV 2106 + A D+ + E + K+ +V + ++ ++ + L ++A+ S G A Sbjct: 687 -----QRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741 Query: 2107 ALAPDAYSTGSSSASST-LKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPS 2165 L G + + T +K K+ S +++ +++ +P +T + + P+ Sbjct: 742 VL------PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795 Query: 2166 GENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQN 2225 S T SA P AA S V PP QN Sbjct: 796 AARAPSAKGTISA----------------PGKVVTAAAQAKQRSPSKVKPPVR---NPQN 836 Query: 2226 SPPVGRKTLPLTTAPEA-GEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPP 2284 S + R + + +A + +G +EDS + SE++S + + E Sbjct: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-----------SEEESDSEEEAETLA 885 Query: 2285 PTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDD 2344 K GK + L K PR A P P G K DD Sbjct: 886 QVKPSGKTHQIRAALAPAK-------------ESPRKGAAPTP-PGKTGPSAAQAGKQDD 931 Query: 2345 PNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASA 2404 + S S E+P + P VDP +++P+ P+ +PA Sbjct: 932 SGSSSEESDSD-GEAPAAVTSAQVIKPPLI--FVDP----NRSPAGPAATPAQ------- 977 Query: 2405 MEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISA 2464 A+ TP K R +S RS S+ +D PA TP + + Sbjct: 978 --------------AQAASTPRKA---RASESTARSSSSESEDEDVIPATQCLTPGIRTN 1020 Query: 2465 VV 2466 VV Sbjct: 1021 VV 1022 >gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] Length = 1838 Score = 84.3 bits (207), Expect = 2e-15 Identities = 192/806 (23%), Positives = 251/806 (31%), Gaps = 144/806 (17%) Query: 75 PEVTEPRKDPQGARGPEGSLLPSPPPSQE-------------REHPSSSMPFAECP---- 117 P + + P+G GP G P PP ++ R+ P S+ F P Sbjct: 836 PRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANG 895 Query: 118 ------------PEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQ 165 P G E GP+ + + P N+ GD A P ER + P Q Sbjct: 896 EKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGP-Q 954 Query: 166 EIAAVPS-------AGRERQPKEEGQK--SSFSFSSGIDQSPGM----SPVPLREPMKAP 212 P G++ P GQ+ + F +G PG+ P PM Sbjct: 955 GPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPM--- 1011 Query: 213 LCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPA-AAQQGTESSAVLEKSP- 270 GE PG G P + G+A + T P A G + L P Sbjct: 1012 --GERGHPG---------PPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPG 1060 Query: 271 ------------LKPMAPIPQDPAPRASDRERG-QGEAPPQYLTDDLEFLRACHLPRSNS 317 LK P P P S ERG G A P + P Sbjct: 1061 DRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGP---------IGIPGRPGPQG 1111 Query: 318 GAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQ 377 P E A ++ Q P G + P GLP PA G G++ D ++ Q Sbjct: 1112 PPGPAGEKGAPGEKGPQGPAGR--DGLQGPVGLPGPA--GPVGPPGEDG-DKGEIGEPGQ 1166 Query: 378 TGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEP 437 G +G K Q G Q G P PS L + P P Sbjct: 1167 KGSKGDKGEQGPPGPTGPQGPIG---QPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGP 1223 Query: 438 GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKG----EHPEGDPGEVPAP- 492 V G+P E D G +G G G + P+G PG + P Sbjct: 1224 PG----PVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPG 1279 Query: 493 SPQERGEHLNTEQSHEVQPGVPPPPLPK----EQSHEVQPGAPPPPLPKAP--SESARGP 546 + E+GE E PG PP PK E+ GA PP PK P + +G Sbjct: 1280 AVGEKGE--PGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGS 1337 Query: 547 PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKR 606 PGP D P + G PG K + EP G PG KR Sbjct: 1338 PGPVG---FPGDPGPP--GEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKR 1392 Query: 607 DPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEE 666 P E + PP K G G + G+P +GE+ Sbjct: 1393 GP---PGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQ 1449 Query: 667 DPVLPPVPDGAGEPTVPEGAIWEGSGLQ-PKCPDTLQSREGLGRMESFLTLESEKSDFP- 724 P PDG P P G GL+ P + GL + + EK D Sbjct: 1450 GLPGSPGPDGPPGPMGPPGL----PGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGL 1505 Query: 725 PTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQG 784 P P PK ++G +T P P GP G+P PP Sbjct: 1506 PGPQGSSGPKGEQG-----------------ITGPSGPIGPPGP-------PGLPGPPGP 1541 Query: 785 ENLAADLGLTALILDQDQQGIPSCPG 810 + G T + G P PG Sbjct: 1542 KGAKGSSGPTGPKGEAGHPGPPGPPG 1567 Score = 59.3 bits (142), Expect = 5e-08 Identities = 152/637 (23%), Positives = 202/637 (31%), Gaps = 98/637 (15%) Query: 86 GARGPEGSLLPSPP-----PSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRR 140 G GP G + P P P ER HP P E G + GP P + Sbjct: 991 GPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGP-AGLPGK 1049 Query: 141 EPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGM 200 + P G FP +R P + A+ G E P G S G + G Sbjct: 1050 DGPPGLRG-----FPGDRGLPGP---VGALGLKGNEGPPGPPGPAGSPG-ERGPAGAAGP 1100 Query: 201 SPVPLREPMKAPL--CGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTP-------E 251 +P R + P GE PG Q G G A P E Sbjct: 1101 IGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGE 1160 Query: 252 APAAAQQGTESSAVLE--KSPLKPMAPIPQDPAPRASDRERG----------QGEAPPQY 299 Q+G++ + P P PI Q P P +D E G +G+ P+ Sbjct: 1161 IGEPGQKGSKGDKGEQGPPGPTGPQGPIGQ-PGPSGADGEPGPRGQQGLFGQKGDEGPRG 1219 Query: 300 LTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVG-AYLPHAELPWGLP----SPA 354 + LP +V P G + P A+ P G P +P Sbjct: 1220 FPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPG 1279 Query: 355 LVPEAGGSGKEALDTIDVQGHPQ--TGMRGTKPNQVVCVAAG-----GQPEGGLPVSPEP 407 V E G G+ + +G P G RG K AAG G P P Sbjct: 1280 AVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPG 1339 Query: 408 SLLTPTEEAHPASSLASFPAAQIPIAVE-----EPGSSSRESVSKAGMPVSADAAKEVVD 462 + P + P PA Q + EPG + S G P + + Sbjct: 1340 PVGFPGDPGPPGEP---GPAGQDGPPGDKGDDGEPGQTG--SPGPTGEPGPSGPPGKRGP 1394 Query: 463 AGLVGLERQVSDLGSKGEHP-EGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPP---- 517 G G E + + G+KGE EG PG+ PQ PG P P Sbjct: 1395 PGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGA-------------PGKPGPDGLRG 1441 Query: 518 LPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPG 577 +P + PG+P P P P GPPG G K G + PG Sbjct: 1442 IPGPVGEQGLPGSPGPDGPPGPM----GPPG-LPGLK----------GDSGPKGEKGHPG 1486 Query: 578 GKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPR 637 P + G+ G+ Q S + G+ ++ PS P PP Sbjct: 1487 LIGLIGPPGEQGEKGDRGLPGPQGSSGPK----GEQGITGPSGPIGPPGPPGLPG--PPG 1540 Query: 638 KGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVP 674 GA + GP EA G P G V+ P+P Sbjct: 1541 PKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLP 1577 Score = 58.9 bits (141), Expect = 7e-08 Identities = 163/744 (21%), Positives = 233/744 (31%), Gaps = 163/744 (21%) Query: 464 GLVGLERQVSDLGSKGEHPE-------GDPGEVPAPSPQERGEHLNTEQSHEVQPGVP-- 514 G+ G++ Q G+ G E G+PG P PQ E+ +PG+P Sbjct: 697 GVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPG-EKGPLGKPGLPGM 755 Query: 515 -----PPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGP--------------TDGAKV 555 PP P ++ + G PP P+ P G PGP T G K Sbjct: 756 PGADGPPGHPGKEGPPGEKGGQGPPGPQGPI----GYPGPRGVKGADGIRGLKGTKGEKG 811 Query: 556 HED--STSPAVAKEGSRSPGDSPGGK-EEAPEPPDG-----GDPGNL--QGEDSQ----- 600 + + +G R PG + E+ PE P G GDPG L GE + Sbjct: 812 EDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPG 871 Query: 601 --AFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASG 658 + ++ P+ P ++ E + +P +G G T GP + +G Sbjct: 872 LPGYPGRQGPKGSIGFPGFPGANGEKGGRGTP--GKPGPRGQRGPT-GPRGERGPRGITG 928 Query: 659 LPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQ-PKCPDTLQSREGL-GRMESFLTL 716 P G P P G P P+G +G PK P ++GL G Sbjct: 929 KPGPKGNSGGDGPAGPPGERGPNGPQGP----TGFPGPKGPPGPPGKDGLPGHPGQRGET 984 Query: 717 ESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHA 776 + PP P V P+ GE T P RG H Sbjct: 985 GFQGKTGPPGPPGVVGPQGPTGE-----------------TGPMGERG----------HP 1017 Query: 777 GVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQ 836 G P PP + L G D G+P G +RG + L L Sbjct: 1018 GPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALG----- 1072 Query: 837 PETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQA 896 LK PP G PG + + I +P P P G++ A Sbjct: 1073 --------LKGNEGPP--GPPGPAGSPGERGPAGAAGPIGIPGRPGPQGP-PGPAGEKGA 1121 Query: 897 LGSELQSQLPKGTLSDTPTSSPTDMVWESSLT-------EESELSAPTRQKLPA-LGEKR 948 G + P+G P + + ++ E+ P ++ GE+ Sbjct: 1122 PGEKG----PQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQG 1177 Query: 949 PEGACG-DGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQH 1007 P G G G + P AD G+ + QQ L G + Sbjct: 1178 PPGPTGPQGPIGQPGPSGAD-------------------GEPGPRGQQGLF-----GQKG 1213 Query: 1008 EEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPAS 1067 +E + PG G L G + +G+ G+ P P P Sbjct: 1214 DEGPRGFPGPPGPV-GLQGLPGPPGEKGETGDVGQMGPPGPPG--------------PRG 1258 Query: 1068 PGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEA 1127 P P D P+ G + P E +A P L G +G Sbjct: 1259 PSGAPGADGPQ---------GPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERG 1309 Query: 1128 GAAETGGSAGAGDPGKQQAPEKPG 1151 E+G S AG PG + P G Sbjct: 1310 EKGESGPSGAAGPPGPKGPPGDDG 1333 Score = 57.0 bits (136), Expect = 3e-07 Identities = 263/1127 (23%), Positives = 350/1127 (31%), Gaps = 220/1127 (19%) Query: 437 PGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHP-EGDPGEVPAPSPQ 495 P S++ES ++A + + A + AG +GL + +G G +G+PG+V P+ Sbjct: 537 PMVSAQESQAQAILQQARLALRG--PAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPR 594 Query: 496 ERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKV 555 GV PP P P +A S+ ARG PG T G K Sbjct: 595 ----------------GVQGPP---------GPAGKPGRRGRAGSDGARGMPGQT-GPKG 628 Query: 556 HE--DSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKD 613 D + ++G R GD G P PP GD G +G+D + E G Sbjct: 629 DRGFDGLAGLPGEKGHR--GDP--GPSGPPGPP--GDDGE-RGDDGEVGPRGLPGEPGPR 681 Query: 614 ELSKPSSDAESRDHP--SSHSAQPPRKGGAG--HTDGPHSQTAEADASGLPHKL------ 663 L P P + QP KG G GP Q A GLP Sbjct: 682 GLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPP 741 Query: 664 GEEDPV----LPPVPDGAGEPTVP--EGAIWEGSGLQPKCPD---TLQSREGLGRMESFL 714 GE+ P+ LP +P G P P EG E G P P G+ + Sbjct: 742 GEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIR 801 Query: 715 TLESEKSD-----FP--------PTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQ 761 L+ K + FP E+ P GE E K G G Sbjct: 802 GLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPK-----GRGGPNGDPG 856 Query: 762 PRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEW 821 P GP + + G+P P + +G ++G PG+ RG Sbjct: 857 PLGPPGEKGKLGV-PGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPT 915 Query: 822 PLLSSEKHLQPSQAQPETSIFDVLKEQAQPP----ENGKETSPSHPGFKDQGADSSQIHV 877 E+ + +P A PP NG + PG K Sbjct: 916 G-PRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKG---------- 964 Query: 878 PVEPQEDNNLPTHGGQEQALGSELQS--QLPKGTLSDTPTSSPTDMVWESSLTEESELSA 935 P P + LP H GQ G + ++ P G + + T + E Sbjct: 965 PPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERG--HPGPPGP 1022 Query: 936 PTRQKLPALGEKRPEGACGD----GQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPN 991 P Q LP L K EG GD G + PP L+ F +G Sbjct: 1023 PGEQGLPGLAGK--EGTKGDPGPAGLPGKDGPPG---LRGFP------------GDRGLP 1065 Query: 992 KSQQALADALEEGSQHEEACQRHPGASEAADGCSPLW-----------GLSKREMASGNT 1040 AL EG PG A P+ G + + A G Sbjct: 1066 GPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEK 1125 Query: 1041 GEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGR-----QQPVPA 1095 G P D + +P PA P P +D + E + Q+G +Q P Sbjct: 1126 GPQGPAGRDGLQGPVGLP-----GPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPG 1180 Query: 1096 PQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAG-AGDPGKQQAPEKPGEAT 1154 P P+ P GE G G G GD G + P PG Sbjct: 1181 P------------TGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVG 1228 Query: 1155 LSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQ 1214 L GL GE+ T + + P A G P + Sbjct: 1229 LQ-GLPG-----PPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVG 1282 Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRG--AEDSGVKAVSSADPRAPGESPCPVG 1272 +P E G P P P +RG E A P+ P P G Sbjct: 1283 EKGEPGEAGEPGLPGEGGPPGP------KGERGEKGESGPSGAAGPPGPKGPPGDDGPKG 1336 Query: 1273 EP-PLALENAASLKLFAGSLAPLLQPGAAGGE-IPAVQASSGSPKARTTEGPV----DSM 1326 P P+ F G P +PG AG + P + G P + GP S Sbjct: 1337 SPGPVG---------FPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSG 1387 Query: 1327 PCLDRMPLLAKGKQATGEEKAA------------TAP----GAGAKASGEGMAG--DAAG 1368 P R P G + EK A T P GA K +G+ G G Sbjct: 1388 PPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVG 1447 Query: 1369 E--------TEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPV 1420 E +G MG P +G SG G P I E+ Sbjct: 1448 EQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEK--------GHPGLIGLIGPPGEQGE 1499 Query: 1421 LGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPP 1467 G PG + +G + +T P GP GPPG LP PP Sbjct: 1500 KGDRGLPGPQGSSGPKG-EQGITGPSGPIG-PPGPPG-----LPGPP 1539 Score = 53.5 bits (127), Expect = 3e-06 Identities = 182/741 (24%), Positives = 231/741 (31%), Gaps = 119/741 (16%) Query: 1297 PGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQA----TGEEKAATAPG 1352 PGA G + + + G P R GP P +R P GK +G + A PG Sbjct: 891 PGANGEK--GGRGTPGKPGPRGQRGPTG--PRGERGPRGITGKPGPKGNSGGDGPAGPPG 946 Query: 1353 AGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIAT-LTGFPDFREH 1411 +G G G G P +D G G + Q T G P Sbjct: 947 ERGPNGPQGPTG-----FPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGP 1001 Query: 1412 IAKIFEKPVLGALATPGEKAGAGRSAV----GKDLTR-PLGPEKL--LDGPPGV----DV 1460 E +G PG G + GK+ T+ GP L DGPPG+ Sbjct: 1002 QGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGD 1061 Query: 1461 TLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAG 1520 LP P L ++ + G GPAG ER GA + G Sbjct: 1062 RGLPGPVGALGLKGNEGPPGPP----------------GPAGSPGERGPAGAAGPIGIPG 1105 Query: 1521 VPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELAS--GLPSPAATQELPVERAAAFQ 1578 P + P GP A G G+ Q R L GLP PA P E + Sbjct: 1106 RPGP----QGPPGP-AGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGE 1160 Query: 1579 VA-PHSHGEEAVAQDRIPSGKQH-QETSACDSPHGEDG-PGDFAHTGVPGHV----PRST 1631 + P G + ++ P G Q P G DG PG G+ G PR Sbjct: 1161 IGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGF 1220 Query: 1632 CAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADT 1691 P + +P E +G PG G A G PP G Sbjct: 1221 PGPPGPVGLQGLPGPPGEKGETGDVGQMGPPG-PPGPRGPSGAPGADGPQGPPGGIG--- 1276 Query: 1692 PLEPGKVA--GAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDP 1749 PG V G GEA G+ L G+ E G + S AG P + P Sbjct: 1277 --NPGAVGEKGEPGEA-GEPGLPGEGGPPGPKGERGEKGESGP-SGAAG----PPGPKGP 1328 Query: 1750 ACSDKAPGMEGTAALHGDS--PARPQQAKEQ-----------------PGPE-RPIPAGD 1789 D G G GD P P A + PGP P P+G Sbjct: 1329 PGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGP 1388 Query: 1790 -GKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSD 1848 GK PP P + + A E + + GP P K P + + Sbjct: 1389 PGK---RGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGP 1445 Query: 1849 ETRGAEGTESSPVADDIIQPAAPADLESPTLAASSY------HGDVVGQVSTDLIAQSIS 1902 G +G SP D P P L P L S H ++G + Sbjct: 1446 V--GEQGLPGSPGPDGPPGPMGPPGL--PGLKGDSGPKGEKGHPGLIGLIGPP----GEQ 1497 Query: 1903 PAAAHAGLP-------PSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFET 1955 GLP P + I PS P G P P P + + Sbjct: 1498 GEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLPGPPGP-----KGAKGSSGPTG 1552 Query: 1956 PESTTPVKAPPAPPPPPPEVI 1976 P+ PP PP PP EVI Sbjct: 1553 PKGEAGHPGPPGPPGPPGEVI 1573 Score = 48.9 bits (115), Expect = 7e-05 Identities = 325/1427 (22%), Positives = 422/1427 (29%), Gaps = 227/1427 (15%) Query: 480 EHPEGDPGEVPAPS--PQERGEHLNTEQSHEVQP----GVPPPPLPKEQSHEVQPGAPPP 533 E PE D G+ P PS P E + TE E+ P P P + E G Sbjct: 281 EDPE-DLGKEPTPSKKPVEAAKE-TTEVPEELTPTPTEAAPMPETSEGAGKEEDVGIGD- 337 Query: 534 PLPKAPSESARGPPGPTD-----GAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDG 588 PSE P D G + + T P E S D+ AP P +G Sbjct: 338 -YDYVPSEDYYTPSPYDDLTYGEGEENPDQPTDPGAGAEIPTSTADTSNSSNPAPPPGEG 396 Query: 589 GDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPH 648 D +L+GE ++ D E D P+S + S P + Q G G G Sbjct: 397 AD--DLEGEFTEETIRNLD-ENYYDPYYDPTS-SPSEIGPGMPANQDTIYEGIGGPRGEK 452 Query: 649 SQTAEAD-------ASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWE-GSGLQPKCP-- 698 Q E G P G E P P P G PT G E G +P P Sbjct: 453 GQKGEPAIIEPGMLIEGPP---GPEGPAGLPGPPGTMGPTGQVGDPGERGPPGRPGLPGA 509 Query: 699 DTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTS 758 D L G M F + V+ +AQ + G GL Sbjct: 510 DGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGLTGR 569 Query: 759 PDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAA 818 P P + E P P+G QG P G+ RG A Sbjct: 570 PGPVGPPGSGGLKGEPGDVGPQGPRG-----------------VQGPPGPAGKPGRRGRA 612 Query: 819 SEWPLLSSEKHLQPSQAQPETSI-FDVLK----EQAQPPENGKETSPSHPGFKDQGADSS 873 S P Q P+ FD L E+ + G P PG + D Sbjct: 613 G-----SDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDG 667 Query: 874 QIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWE----SSLTE 929 ++ LP G LG PKG T M + ++ Sbjct: 668 EV-------GPRGLPGEPGPRGLLG-------PKGPPGPPGPPGVTGMDGQPGPKGNVGP 713 Query: 930 ESELSAPTRQKLP-ALGEKRPEGACG-DGQSSRVSPPAADVLKDFSLAGNFSRKETC--- 984 + E P +Q P A G P+GA G G+ + P + KE Sbjct: 714 QGEPGPPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGE 773 Query: 985 CTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAP 1044 GQGP Q + G + + + G ++ G G G+ GE Sbjct: 774 KGGQGPPGPQGPIGYPGPRGVKGADGIRGLKG-TKGEKGEDGFPGFKGDMGIKGDRGEIG 832 Query: 1045 PCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWA 1104 P P +D PE G P+ P +K + Sbjct: 833 PPGPRG-----------------------EDGPEGPKGRGGPNGDPGPLGPPGEKGKLGV 869 Query: 1105 TS-----DAESPKLLASFPSAGEQGGEAGAAETGGSAG----------AGDPGKQQAPEK 1149 + PK FP GE G T G G G+ G + K Sbjct: 870 PGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGK 929 Query: 1150 PGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIP--RST 1207 PG S G G P +D L G P R Sbjct: 930 PGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDG------LPGHPGQRGE 983 Query: 1208 MDFSTHQAVPDPKELL-LSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGE 1266 F P P ++ GP P H G + A PG Sbjct: 984 TGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGP 1043 Query: 1267 SPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGP---- 1322 + P + P L + G + L G G P +GSP R G Sbjct: 1044 AGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGP--PGPPGPAGSPGERGPAGAAGPI 1101 Query: 1323 -VDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAA-----GETEGSMER 1376 + P P A K A GE+ G G+ G A GE +G Sbjct: 1102 GIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGE-DGDKGE 1160 Query: 1377 MGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRS 1436 +GEP Q +G G EQ G P I + GA PG + G Sbjct: 1161 IGEPGQKGSKGDKG------EQ-----GPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLF 1209 Query: 1437 AVGKDLTRPLGPEKLLDGPPG-VDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASD 1495 D GP + GPPG V + LP PP + E + P Sbjct: 1210 GQKGD----EGP-RGFPGPPGPVGLQGLPGPPGE-----------KGETGDVGQMGPP-- 1251 Query: 1496 KLLGPAGLTWERNLPGA-GVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLER-SR 1553 GP G PGA G G+ E+ E A PGL G+ + R Sbjct: 1252 ---GPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGER 1308 Query: 1554 QELASGLPSPAATQELPVERAAAFQVAPH-SHGEEAVAQDRIPSGKQHQETSACDSPHGE 1612 E PS AA P + P S G D P G+ P G+ Sbjct: 1309 GEKGESGPSGAAGP--PGPKGPPGDDGPKGSPGPVGFPGDPGPPGE--------PGPAGQ 1358 Query: 1613 DG-PGDFAHTGVPGHV--PRSTCAPSP------------------QREVLTVPEANSE-- 1649 DG PGD G PG P T P P Q E EA E Sbjct: 1359 DGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGP 1418 Query: 1650 PWTLDTLGGERRPGVTA--GILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEA-- 1705 P +G + PG G+ + +G Q P P + P+ P + G G++ Sbjct: 1419 PGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGP 1478 Query: 1706 ------EGDITLSTAETQACASGDLPEAGTTRTFSVVAGD--LVLPGSCQDPACSDKAPG 1757 G I L + GD G + S G+ + P P PG Sbjct: 1479 KGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGS-SGPKGEQGITGPSGPIGPPGPPGLPG 1537 Query: 1758 MEGTAALHGDS-PARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDET 1803 G G S P P+ PGP P P G+V P + T Sbjct: 1538 PPGPKGAKGSSGPTGPKGEAGHPGPPGP-PGPPGEVIQPLPIQASRT 1583 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 83.6 bits (205), Expect = 3e-15 Identities = 269/1331 (20%), Positives = 434/1331 (32%), Gaps = 235/1331 (17%) Query: 1247 GAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPA 1306 G DS + SS+ E V + + ++ + A AP PG G P Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA--PGKVGDVTPQ 251 Query: 1307 VQASSGSPKART------TEGPVDSMPCLDRMPLLAKGKQATGEE----KAATAPGAGAK 1356 V+ + P R +E + + P + + E+ +AA+AP G Sbjct: 252 VKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP 311 Query: 1357 ASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSE--------QIATLTGFPDF 1408 G A S + G+P +D + + D+ E Q Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371 Query: 1409 REHIAKIFEKPVLGALATPGEKAG--AGRSAVGK-------------------DLTRPLG 1447 A E P GA P K G ++ GK +P G Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431 Query: 1448 --PEKLLDGPPGVDVT---LLPAPP-------ARLQVEKKQQLA------GEAEISHLAL 1489 P+ P + PAPP A++QV K+++ + +++ LA Sbjct: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 1490 QDPASDKLLGPAGLTWERNLPGAG-VGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQ 1548 + A K LG + + G G +GK VPP P W E + S Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW---EEDSESS 548 Query: 1549 LERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDS 1608 E S +P+ A + Q P S + Q P Q + D+ Sbjct: 549 SEESSDSSDGEVPTAVAPAQ-EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDN 607 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 + D A + P + A + + L +P+ + P +T + V G Sbjct: 608 SESSEESSDSADS---EEAPAAMTA-AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGT 663 Query: 1669 LEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGD-----ITLSTAETQACASGD 1723 R A G ++PA + VA P + + ++ E++ + + ++ + ++ G Sbjct: 664 QAPRKA-GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722 Query: 1724 LPEAGTTRTFSVVAGDL------VLPGSCQDPACSDKAPGMEGTAALHGDSPA------- 1770 +A + V G L VLPG KA E + + +S + Sbjct: 723 QVKAASV----PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778 Query: 1771 -------RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESP 1823 + QAK P R P+ G + S P T + + +P ++ +P Sbjct: 779 AQVKTSVKKTQAKANPAAAR-APSAKGTI---SAPGKVVTAAAQAKQRSPSKVKPPVRNP 834 Query: 1824 R------PGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESP 1877 + GP+ +PSV K A + +E G+ ES ++ E+ Sbjct: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD------------SEEEAE 882 Query: 1878 TLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCP 1937 TLA G Q+ L SP A PP + PS Sbjct: 883 TLAQVKPSGK-THQIRAALAPAKESPRKGAAPTPPG-----------------KTGPSAA 924 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 K S SEE+ E+ P A PP + +P S P P Sbjct: 925 QAGKQDDSGSSSEESDSDGEA--PAAVTSAQVIKPPLIFVDPNRS----PAGPAATPAQA 978 Query: 1998 PVPDGPRSDSVEGSPFRPPSHSFSAVFDEDK-PIASSGTYNLDFDNIELVDTFQTLEPRA 2056 PR S R S S DED P T + + + + + P+A Sbjct: 979 QAASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKA 1035 Query: 2057 --------------SDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGN 2102 SD K QEG + ++P +T +S S+QA + Sbjct: 1036 SMAGASSSKESSRISDGKKQEGPATQVDSAVGTLP---ATSPQSTSVQAKGTNKLRKPKL 1092 Query: 2103 PEA--VALAPDAY-STGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPP---VKETQQE 2156 PE AP++ + SS SS+ P K T PT + V+ET E Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1152 Query: 2157 PDEESLVPSGENLASETKTESAKTEGPSPALLEETPLE--PAVGPKAACPLD-------- 2206 E+ +V ++L S T T S A L+ P+V A D Sbjct: 1153 SSEDDVVAPSQSLLSGYMTPGL-TPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK 1211 Query: 2207 SESAEGVVPPASGGGRVQN--SPPVGRKTLPLTTAPEA--------------GEVTPSDS 2250 + A G++ P +GG + +P RK P+A G+ P + Sbjct: 1212 PQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNE 1271 Query: 2251 GGQEDSPAKGLSVRLEFDYSE--------DKSSWDNQQENPPPTKKIGKKPVAKMPLRRP 2302 + S K L+ LE + + + W++++ K G +P A+ P + Sbjct: 1272 AQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKR-----KLSGDQPAARTPRSKK 1326 Query: 2303 KMK----------KTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 2352 K K +PEK T + D+ KG + Sbjct: 1327 KKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL--------------G 1372 Query: 2353 TSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDG 2412 + ++ P+ Q + D+S K K K E A +A+ D Sbjct: 1373 SQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDS 1432 Query: 2413 DGLNKPAKKKK 2423 + ++ KKKK Sbjct: 1433 ESPSQKKKKKK 1443 Score = 78.6 bits (192), Expect = 9e-14 Identities = 301/1443 (20%), Positives = 471/1443 (32%), Gaps = 252/1443 (17%) Query: 8 SDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSAS 67 S N L A P S + ++ K T S H + L G + S Sbjct: 107 STNSSVLGADLPSSMKEKAKAET--EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164 Query: 68 LDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLA-SPA 126 + LVS E GA G + S + SSS E EG + PA Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSS---DETDVEGKPSVKPA 221 Query: 127 AAPEDGPQT-QSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQK 185 T +SP R+ AP APG + TP + A+P A R ++P+EE + Sbjct: 222 QVKASSVSTKESPARKAAP-APGKVGDV--------TPQVKGGALPPAKRAKKPEEESES 272 Query: 186 SSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVAS 245 S G ES+E+ AG ++ + + Sbjct: 273 SE---------------------------------EGSESEEEAPAGTRSQVKASEKILQ 299 Query: 246 VQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLE 305 V+ A +A +GT P K A Q A + + E+ + +D E Sbjct: 300 VR----AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSESSSEESSDSEE 351 Query: 306 FLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKE 365 A + ++V AAS + + P P P G PA+ G +E Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP---APPGKTGPAVAKAQAGKREE 408 Query: 366 ALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP---VSPEPSLLTPTEEAHPASSL 422 + + + A +P G P + P+ +P + A PA Sbjct: 409 DSQSSSEESDSEEE-----------APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457 Query: 423 ASFP-AAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH 481 + P AAQ+ + +E SR S ++ A AA +G QV + G Sbjct: 458 KTGPAAAQVQVGKQE--EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG 515 Query: 482 PEG------DPGEVPAPSPQ------ERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPG 529 P G PG+V +P E ++E+S + G P + Q + Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575 Query: 530 APPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGG 589 P S A+GPP V + P E S DS EEAP Sbjct: 576 LQAKP----TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-ADSEEAPAAMTA- 629 Query: 590 DPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHS 649 +QA + + P+ K K ++ A ++ P Q PRK G T S Sbjct: 630 ---------AQAKPALKIPQT-KACPKKTNTTASAKVAPVRVGTQAPRKAGTA-TSPAGS 678 Query: 650 QTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGR 709 A A + P + + G A G GLQ K ++ + LG+ Sbjct: 679 SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAA-SVPVKGSLGQ 737 Query: 710 MESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDA 769 T PT A K ++ ES+ E D E SP Q + + Sbjct: 738 G----TAPVLPGKTGPTVTQVKAEKQEDSESSEE-----ESDSEEAAASPAQVK-TSVKK 787 Query: 770 SRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPS-------CPGEGWI--RGAASE 820 ++ + + P + + G Q +Q PS P + RG AS Sbjct: 788 TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV 847 Query: 821 WPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVE 880 + + +Q PE +E++ E + + P K + QI + Sbjct: 848 PSVGKAVATAAQAQTGPEED-SGSSEEESDSEEEAETLAQVKPSGK-----THQIRAALA 901 Query: 881 PQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQK 940 P +++ P G G S G D+ +SS EES+ Sbjct: 902 PAKES--PRKGAAPTPPGKTGPSAAQAGKQDDSGSSS-----------EESDSDG----- 943 Query: 941 LPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADA 1000 E + + PP V + S AG + P K++ + + A Sbjct: 944 ---------EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTA 994 Query: 1001 LEEGSQHEE-----ACQ---------------RHPGASEAADGCSPLWGLSKREMASGNT 1040 S+ E+ A Q HP + A ++ G Sbjct: 995 RSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKK 1054 Query: 1041 GEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKM 1100 E P Q DS AV LPA +P S V T + R+ +P QQ Sbjct: 1055 QEGPATQVDS-----AVGTLPATSPQSTSV----------QAKGTNKLRKPKLPEVQQAT 1099 Query: 1101 ECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLL 1160 + +SD +S S E+ GE G GA Sbjct: 1100 KAPESSDDSEDSSDSS--SGSEEDGE-------GPQGA---------------------- 1128 Query: 1161 QTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPAREL--GGIPRSTMDFSTHQAVPD 1218 ++ H L + T L E AE +S D + P++ L G + ++ + Sbjct: 1129 KSAHTLVGPTPSRTETLVEETAAE---SSEDDVVAPSQSLLSGYMTPGLTPANSQASKAT 1185 Query: 1219 PKELLLSGPPEV----AAPDTPYLHVDSAAQRGA-----EDSGVKAVSSADPRAPGESPC 1269 PK L P V AA D P ++ Q+ A + G +A S P+ + Sbjct: 1186 PK---LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK 1242 Query: 1270 PVGEP---PLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSM 1326 G P LAL++ + + G PL + + + + + VD+ Sbjct: 1243 GAGNPQASTLALQSNIT-QCLLGQPWPLNEAQVQASVVKVLTELLEQERKKV----VDTT 1297 Query: 1327 PCLDRMPLLAKGKQATGEEKAATAPGAGAKAS-GEGMAGDAAGETE-GSMERMGEPSQDP 1384 R ++ ++ +G++ AA P + K G G G+A+ E S G+ +D Sbjct: 1298 KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDK 1357 Query: 1385 KQG 1387 G Sbjct: 1358 ASG 1360 Score = 77.0 bits (188), Expect = 3e-13 Identities = 277/1251 (22%), Positives = 413/1251 (33%), Gaps = 214/1251 (17%) Query: 251 EAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDD-LEFLR 308 EA A + T A S L P +A + G+ G + P T + L Sbjct: 93 EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLL 152 Query: 309 ACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALD 368 + PR + A P A S+ + V A+ A+ G+ S + + D Sbjct: 153 SGKSPRKS--AEPSANTTLVSETEEEGSVPAFGAAAKP--GMVSAGQADSSSEDTSSSSD 208 Query: 369 TIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLL---TPTEE--AHPASSLA 423 DV+G P KP QV + + +P P + TP + A P + A Sbjct: 209 ETDVEGKPSV-----KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263 Query: 424 SFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPE 483 P + + E GS S E + AG A+++++ + + P Sbjct: 264 KKPEEESESS--EEGSESEEE-APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320 Query: 484 GDPGEVP----APSPQERGEHLNTEQS--HEVQPGVPPPPLPKEQSHEVQPGAPPPPLPK 537 G G V A P+E E + E S E P K Q GA P + Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380 Query: 538 APSESAR-GPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQG 596 +P + A PPG T PAVAK + GK E Sbjct: 381 SPRKGAAPAPPG----------KTGPAVAK--------AQAGKRE--------------- 407 Query: 597 EDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADA 656 EDSQ+ S + D E +KPS A S+ + + PRKG A P +T A A Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---PAPPRKTGPAAA 464 Query: 657 SGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWE---GSGLQPKCPDTLQSREGLGRMESF 713 K E+ D E A G Q K T+ G+G + Sbjct: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM----GMGPLGKG 520 Query: 714 LTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGE-GLLTSPDQPRGPACDASRQ 772 P TP A+V ++ ES+ E S DGE +P Q + + Sbjct: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 773 EFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQP 832 + PPQ A +D + S + E P + +P Sbjct: 580 PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS-----ADSEEAPAAMTAAQAKP 634 Query: 833 SQAQPET-------------SIFDVLKEQAQPPENGKETSP--SHP----GFKDQGADSS 873 + P+T + V P + G TSP S P G + DSS Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694 Query: 874 QIHVPVEPQEDNNLPTHGGQEQALGSELQ---------SQLPKGTLSDTP-TSSPTDMVW 923 +E L GQ +++G LQ L +GT P + PT Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754 Query: 924 ESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKET 983 ++ E+SE S A ++ +P AA + S G S Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA---RAPSAKGTIS---- 807 Query: 984 CCTGQGPNKSQQALADALEEGSQHEEACQRHP-GASEAADGCSPLWGLSKR--------- 1033 P K A A A + + R+P ++ A G + + + K Sbjct: 808 -----APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 862 Query: 1034 --EMASGNTGEAPPCQPDSVALLDAVP------CLPALAPA--SP--GVTPTQDAPETEA 1081 E SG++ E + ++ L P ALAPA SP G PT P Sbjct: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT--PPGKTG 920 Query: 1082 CDETQEGRQQPVPAPQQKMECWATSDAESPKLLAS-------FPSAGEQGGEAGAAETGG 1134 Q G+Q + ++ + SD E+P + S AG A T Sbjct: 921 PSAAQAGKQDDSGSSSEESD----SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPA 976 Query: 1135 SA-GAGDPGKQQAPEKPGEATLSCG----LLQTEHCLTSGEEASTSALRESCQAEHPMAS 1189 A A P K +A E ++ S ++ CLT G + + + P AS Sbjct: 977 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036 Query: 1190 CQDALLPARELGGI--------PRSTMDFST---HQAVPDPKELLLSGPPEVAAPDTPYL 1238 A ++E I P + +D + P + G ++ P P + Sbjct: 1037 MAGA-SSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEV 1095 Query: 1239 HVDSAAQRGAEDSGVKAVSSADPRAPGESP-------CPVGEPPLALEN----------- 1280 + A ++DS + SS+ GE P VG P E Sbjct: 1096 QQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1155 Query: 1281 ----AASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLA 1336 A S L +G + P L P + QAS +PK +DS P + LA Sbjct: 1156 DDVVAPSQSLLSGYMTPGLTPANS-------QASKATPK-------LDSSPSVS--STLA 1199 Query: 1337 KGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 G+++A AG + G A+G T + S+ PK+G Sbjct: 1200 AKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTP-------QKSRKPKKG 1243 Score = 70.1 bits (170), Expect = 3e-11 Identities = 225/1144 (19%), Positives = 374/1144 (32%), Gaps = 141/1144 (12%) Query: 1529 ERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEA 1588 E P A PG G Q++ A P E E + + + AP + Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291 Query: 1589 VAQDRIPSGKQHQETSACDSPHGEDGPGDF-AHTGVPGHVPRSTCAPSPQREVLTVPEAN 1647 A ++I Q +A G G G A G G V T A P+ + + E + Sbjct: 292 KASEKIL-----QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346 Query: 1648 SEPWTLDTLGGERRPGVTAGILEMR-----NALGNQSTPAPPTGEVADTPLEPGKVAGAA 1702 S+ E +L+ + + +G S PA + P PGK A Sbjct: 347 SD--------SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398 Query: 1703 GEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTA 1762 +A+ +++ + S EA P + S KAP + + Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEA---------------PAQAKP---SGKAPQVRAAS 440 Query: 1763 ALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRES 1822 A +SP + P P R +V V E + + EE +DRE+ Sbjct: 441 APAKESPRKGAA----PAPPRKTGPAAAQVQVGKQEEDSRS--------SSEESDSDREA 488 Query: 1823 PRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPA--------DL 1874 + P +P+V K S G G + PV + PA P+ D Sbjct: 489 -LAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545 Query: 1875 ESPTLAAS-SYHGDVVGQV------STDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGD 1927 ES + +S S G+V V S I Q+ P ++ A PP A P Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-KPTSSPAKGPPQKA-------GPVAV 597 Query: 1928 RVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPP 1987 +V+A P D ++ SSDS ++ E P + T +A PA P + P+ +T Sbjct: 598 QVKAEKPM--DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT---- 651 Query: 1988 EEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVD 2047 ++ PV G ++ G+ P S + +P S + E Sbjct: 652 ----ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707 Query: 2048 TFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKS---------------TLSRSLSLQAS 2092 T+ S K + K SVP+ S T+++ + + Sbjct: 708 LAVTVGQAKSVGKGLQVK-------AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760 Query: 2093 DFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKE 2152 D + + + E A +P T S + R PS K + T + Sbjct: 761 DSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819 Query: 2153 TQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEG 2212 Q+ P + + P N + T PS T + GP+ DS S+E Sbjct: 820 KQRSPSK--VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE----DSGSSEE 873 Query: 2213 VVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSED 2272 + P G KT + A + +P G S + Sbjct: 874 ESDSEEEAETLAQVKPSG-KTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932 Query: 2273 KSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAK 2332 SS + + + V K PL ++P TPA ++ + P ++ Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAASTPRKARASE 991 Query: 2333 GTYTFDIDKWDDPNFNPFS---STSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSK-TP 2388 T + +D + P + + +P P K SS+ + Sbjct: 992 STARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISD 1051 Query: 2389 SSPSKSPAS------FEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPL 2442 + PA+ +PA++ ++ V G NK K K ++ T + S Sbjct: 1052 GKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1111 Query: 2443 SDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLS 2502 SD S P+ +V T + + E+ + D PS Sbjct: 1112 SDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEE------TAAESSEDDVVAPSQSL 1165 Query: 2503 TFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDD-------APKKQALYLMFDTSQ 2555 T +P + + +++ + S+L DD P++ A L T Sbjct: 1166 LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG 1225 Query: 2556 ESPVKSSPVRMSESPTPCSGSSFEETEALVN--TAAKNQHPVPRGLAPNQESHLQVPEKS 2613 + + + S P +G+ T AL + T P P A Q S ++V + Sbjct: 1226 KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTEL 1285 Query: 2614 SQKE 2617 ++E Sbjct: 1286 LEQE 1289 >gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo sapiens] Length = 1818 Score = 79.3 bits (194), Expect = 5e-14 Identities = 202/840 (24%), Positives = 273/840 (32%), Gaps = 192/840 (22%) Query: 82 KDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPP--EGCLASPAAAPEDGPQTQSPR 139 + PQG +GP G P PP PP +G P E G Q ++ Sbjct: 930 RGPQGPQGPVGFPGPKGPPG---------------PPGKDGLPGHPGQRGETGFQGKT-- 972 Query: 140 REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPG 199 P PG + P E + G P G++ ++G + + G Sbjct: 973 ---GPPGPGGVVG-------PQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKG 1021 Query: 200 MSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQG 259 +P + G+ D P G GFP +G+ Q P +G Sbjct: 1022 -------DPGPQGISGK-DGPAGLR--------GFP---GERGLPGAQGAP-----GLKG 1057 Query: 260 TESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDDLEFLRACHLPRSNSG 318 E P P P P S ERG G A P L P Sbjct: 1058 GEG----------PQGP----PGPVGSPGERGSAGTAGPIGLPG---------RPGPQGP 1094 Query: 319 AAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQT 378 P E A ++ Q P G + P GLP PA AG G++ D ++ Q Sbjct: 1095 PGPAGEKGAPGEKGPQGPAGR--DGVQGPVGLPGPA--GPAGSPGEDG-DKGEIGEPGQK 1149 Query: 379 GMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPG 438 G +G K G P PV P + E P F A PG Sbjct: 1150 GSKGDKGEN----GPPGPPGLQGPVG-APGIAGGDGEPGPRGQQGMFGQKGDEGARGFPG 1204 Query: 439 SSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKG----EHPEGDPGEV-PAPS 493 + G+P E D G +G G +G + P+G PG V Sbjct: 1205 PPG--PIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGG 1262 Query: 494 PQERGEHLNTEQSHEVQPGVPPPPLPK----EQSHEVQPGAPPPPLPKAPSESARGPPGP 549 E+GE E + PG PK E+ PGA PP A+GPPG Sbjct: 1263 VGEKGE--PGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPP-------GAKGPPG- 1312 Query: 550 TDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPE 609 DG K G+ P PG P PP G+PG G+D D + Sbjct: 1313 DDGPK-------------GNPGPVGFPGD----PGPP--GEPGP-AGQDGVGGDKGEDGD 1352 Query: 610 VGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHK---LGEE 666 G+ PS +A P PP GA G EA A G P K +G + Sbjct: 1353 PGQPGPPGPSGEAGPPGPPGKRG--PPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQ 1410 Query: 667 DPVLPPVPDG-------AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESE 719 P P P+G GE +P A +G P GL ++ + E Sbjct: 1411 GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDG-------PPGPMGPPGLPGLKGDPGSKGE 1463 Query: 720 KSDFPPTPVAEVAPKAQEGE----STLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFH 775 K P + + P ++GE + G+G + P P GP Sbjct: 1464 KGH--PGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP---------- 1511 Query: 776 AGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASE-WPLLSSEK---HLQ 831 G P P + + G T + G+P PG G + P+LSS+K H + Sbjct: 1512 PGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTE 1571 Query: 832 PSQAQPETSIFDV-------------LKE-----------QAQPPENGKETSPSHPGFKD 867 QA + +I D LK+ Q P K+ SHP F D Sbjct: 1572 GMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPD 1631 Score = 70.9 bits (172), Expect = 2e-11 Identities = 183/793 (23%), Positives = 247/793 (31%), Gaps = 126/793 (15%) Query: 38 TPGSPDHRDASSIGSVGLGGFCTASESSASLDPC-LVSPEVTEPRKDPQGARGPEGSLLP 96 TPG+P G G+ G ++ P P + PQG GP+G + P Sbjct: 671 TPGAP--------GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGP 722 Query: 97 SPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPA 156 + + + +P A+ PP P + G + P P P +P Sbjct: 723 PGEKGPQGKPGLAGLPGADGPP----GHPGKEGQSGEK--GALGPPGPQGP----IGYPG 772 Query: 157 ERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPV----PLREPMKAP 212 R S G + + G K + + P P +A Sbjct: 773 PRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG 832 Query: 213 LCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLK 272 G+ G + K G P RQG P P A + + P Sbjct: 833 PTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRG 892 Query: 273 PMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQES 332 P PR S RG P P+ SG + + Sbjct: 893 QRGPT----GPRGSRGARGPTGKPG---------------PKGTSGG--DGPPGPPGERG 931 Query: 333 CQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVA 392 Q P G P G P P P G GK+ L GHP G RG Q Sbjct: 932 PQGPQG--------PVGFPGPKGPP--GPPGKDGLP-----GHP--GQRGETGFQ----G 970 Query: 393 AGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPV 452 G P G V P+ PT E P P PG++ +E G P Sbjct: 971 KTGPPGPGGVVGPQG----PTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAK--GDPG 1024 Query: 453 SADAAKEVVDAGLVGLERQVSDLGSKG-------EHPEGDPGEVPAPSPQERGEHLNTEQ 505 + + AGL G + G++G E P+G PG P SP ERG Sbjct: 1025 PQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPG--PVGSPGERGS------ 1076 Query: 506 SHEVQP-GVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAV 564 + P G+P P P+ PP P + + +GP GP D V Sbjct: 1077 AGTAGPIGLPGRPGPQ---------GPPGPAGEKGAPGEKGPQGPAG-----RDGVQGPV 1122 Query: 565 AKEGSRSPGDSP---GGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSD 621 G P SP G K E EP G G+ +GE+ VG + + Sbjct: 1123 GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGD-KGENGPPGPPGLQGPVGAPGI----AG 1177 Query: 622 AESRDHPSSHSAQPPRKG--GAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGE 679 + P +KG GA GP G P + GE V P P G Sbjct: 1178 GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1237 Query: 680 PTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGE 739 P P+G G+ P ++ S G+G + PP PK + GE Sbjct: 1238 PRGPQGP--NGADGPQGPPGSVGSVGGVGEKGE---PGEAGNPGPPGEAGVGGPKGERGE 1292 Query: 740 STLEIRKMGSCDGEGLLTSP--DQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALI 797 E G+ G P D P+G G P PP A G+ Sbjct: 1293 KG-EAGPPGAAGPPGAKGPPGDDGPKGNPGPVG----FPGDPGPPGEPGPAGQDGVGG-- 1345 Query: 798 LDQDQQGIPSCPG 810 D+ + G P PG Sbjct: 1346 -DKGEDGDPGQPG 1357 Score = 62.4 bits (150), Expect = 6e-09 Identities = 169/717 (23%), Positives = 230/717 (32%), Gaps = 104/717 (14%) Query: 463 AGLVGLERQVSDLGSKGEH----PEGDPGEVPAPSPQ-------ERGEHLNTEQSHEVQP 511 AG+ G ++G +GE +G+PG P PQ E+G Q Sbjct: 681 AGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP-----QGKPGLA 735 Query: 512 GVP----PPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKE 567 G+P PP P ++ + GA PP P+ P G PGP G K D + Sbjct: 736 GLPGADGPPGHPGKEGQSGEKGALGPPGPQGPI----GYPGPR-GVK-GADGVRGLKGSK 789 Query: 568 GSRSPGDSPGGKEEAPEPPDGGDPGNL--QGEDSQAFSSKRDPEVGKDELSKPSSDAESR 625 G + PG K + D G+ G + +GED R G S + + Sbjct: 790 GEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKL 849 Query: 626 DHPSSHSAQPPRKGGAGHTD-----GPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEP 680 P P R+G G T G + + +G P G+ P P GA P Sbjct: 850 GVPGL-PGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 908 Query: 681 TVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGES 740 T G G P P + +G F + PP Q GE+ Sbjct: 909 TGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPG--PPGKDGLPGHPGQRGET 966 Query: 741 TLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQ 800 + K G G G + P P G + H G P PP + L G D Sbjct: 967 GFQ-GKTGP-PGPGGVVGPQGPTGETGPIGERG-HPGPPGPPGEQGLPGAAGKEGAKGDP 1023 Query: 801 DQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSP 860 QGI G +RG E+ L +Q P LK P G Sbjct: 1024 GPQGISGKDGPAGLRG-------FPGERGLPGAQGAPG------LKGGEGP--QGPPGPV 1068 Query: 861 SHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLS-DTPTSSPT 919 PG + + I +P P P G++ A G E Q P G P P Sbjct: 1069 GSPGERGSAGTAGPIGLPGRPGPQGP-PGPAGEKGAPG-EKGPQGPAGRDGVQGPVGLPG 1126 Query: 920 DMVWESSLTEESELSAPTRQKLPALGEKRPEGACGD-GQSSRVSPPAAD-VLKDFSLAGN 977 S E+ + +GE +G+ GD G++ PP + +AG Sbjct: 1127 PAGPAGSPGEDGDKG--------EIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGG 1178 Query: 978 FSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMAS 1037 G+ + QQ + G + +E + PG G L GL Sbjct: 1179 --------DGEPGPRGQQGMF-----GQKGDEGARGFPG----PPGPIGLQGLPGPPGEK 1221 Query: 1038 GNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQ 1097 G G+ P P P PG Q P + G V Sbjct: 1222 GENGDVGPMGP----------------PGPPGPRGPQ-GPNGADGPQGPPGSVGSVGGVG 1264 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQG--GEAGAAETGGSAGA-GDPGKQQAPEKPG 1151 +K E + P GE+G GEAG G GA G PG PG Sbjct: 1265 EKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPG 1321 Score = 47.4 bits (111), Expect = 2e-04 Identities = 176/795 (22%), Positives = 234/795 (29%), Gaps = 177/795 (22%) Query: 1261 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE 1320 PR + P G+P K +G P PG G + P Q G P + Sbjct: 899 PRGSRGARGPTGKP--------GPKGTSGGDGPPGPPGERGPQGP--QGPVGFPGPKGPP 948 Query: 1321 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETE-------GS 1373 GP P D +P + TG + PG G +G G+ E G Sbjct: 949 GP----PGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGP 1004 Query: 1374 MERMGEPSQDPKQGTSGGVD----TSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGE 1429 G P K+G G + + A L GFP E+ + GA PG Sbjct: 1005 PGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPG---------ERGLPGAQGAPGL 1055 Query: 1430 KAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLAL 1489 K G G P GP G PG + A P L Sbjct: 1056 KGGEGPQG-------PPGPV----GSPGERGSAGTAGPIGL------------------- 1085 Query: 1490 QDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQL 1549 P GP G E+ PG ++ P+GP A G++G Sbjct: 1086 --PGRPGPQGPPGPAGEKGAPG----------------EKGPQGP-AGRDGVQGPV---- 1122 Query: 1550 ERSRQELASGLPSPAATQELPVERAAAFQVA-PHSHGEEAVAQDRIPSGKQHQETSACDS 1608 GLP PA P E ++ P G + + P G Sbjct: 1123 ---------GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPG----------- 1162 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 P G GP G PG + P P+ + + E G PG I Sbjct: 1163 PPGLQGP-----VGAPG-IAGGDGEPGPRGQQGMFGQKGDE-------GARGFPGPPGPI 1209 Query: 1669 LEMRNALGNQSTPAPP--TGEVADT-PLEPGKVAGAAGEAEGDITLSTAETQACASGDLP 1725 G Q P PP GE D P+ P G G Q D P Sbjct: 1210 -------GLQGLPGPPGEKGENGDVGPMGPPGPPGPRGP------------QGPNGADGP 1250 Query: 1726 EAGTTRTFSVVA-GDLVLPGSCQDPACSDKAP--GMEGTAALHGDS----PARPQQAKEQ 1778 + SV G+ PG +P +A G +G G++ A P AK Sbjct: 1251 QGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1310 Query: 1779 PGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGP------SMLPS 1832 PG + P G V P P P Q + D + +PGP + P Sbjct: 1311 PGDDGP-KGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1369 Query: 1833 VPKKDAPR----VMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDV 1888 P K P + +G G E P + P PA P G V Sbjct: 1370 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPE-GLRGIPGPV 1428 Query: 1889 VGQVSTDLIAQSISPAAAHA-------GLPPSAAEH----IVSPSAPAGDRVEASTPSCP 1937 Q Q P G P S E ++ P G++ E P Sbjct: 1429 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLP 1488 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 D P P+ P P P P+ + ST P ++ G Sbjct: 1489 GTQGSPGAKGDGG----IPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1544 Query: 1998 PVPDGPRSDSVEGSP 2012 P GP + ++ P Sbjct: 1545 PGSPGPPGEVIQPLP 1559 Score = 38.9 bits (89), Expect = 0.076 Identities = 149/644 (23%), Positives = 198/644 (30%), Gaps = 108/644 (16%) Query: 1345 EKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTG 1404 E P A +G+ AGE +G + G P +QG G TG Sbjct: 821 EDGPEGPKGRAGPTGDPGPSGQAGE-KGKLGVPGLPGYPGRQGPKGS-----------TG 868 Query: 1405 FPDFREHIAKIFEKPVLGALATPGEKAGAGR--SAVGKDLTRPLGPEKLL--DGPPGVDV 1460 FP F + + V G G++ G S + T GP+ DGPPG Sbjct: 869 FPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPG--- 925 Query: 1461 TLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAG 1520 PP + Q G P GP G + LPG + G Sbjct: 926 -----PPGERGPQGPQGPVG--------FPGPK-----GPPGPPGKDGLPGHPGQRGETG 967 Query: 1521 VPPTLREDERPEGPGAAW--PGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQ 1578 + P GPG G G+ ER G P P Q LP Sbjct: 968 ----FQGKTGPPGPGGVVGPQGPTGETGPIGERGHP----GPPGPPGEQGLP-------- 1011 Query: 1579 VAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDG-PGDFAHTGVPGHVPRSTCAPSPQ 1637 + G+E D P G S D P G G PG+ G G P PQ Sbjct: 1012 ---GAAGKEGAKGDPGPQG-----ISGKDGPAGLRGFPGERGLPGAQG-APGLKGGEGPQ 1062 Query: 1638 REVLTV--PEANSEPWTLDTLGGERRPGVTA--GILEMRNALGNQSTPAPPTGEVADTPL 1693 V P T +G RPG G + A G + P + P+ Sbjct: 1063 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1122 Query: 1694 E---PGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPA 1750 P AG+ GE +GD Q + GD E G + G + PG A Sbjct: 1123 GLPGPAGPAGSPGE-DGDKGEIGEPGQKGSKGDKGENGPPGPPGL-QGPVGAPGI----A 1176 Query: 1751 CSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPP-EPDETHDPKLQ 1809 D PG G + G + A+ PGP PI G + PP E E D Sbjct: 1177 GGDGEPGPRGQQGMFGQKG--DEGARGFPGPPGPI----GLQGLPGPPGEKGENGDV--- 1227 Query: 1810 HLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA 1869 GP P P P+ + +D +G G+ S + + Sbjct: 1228 ----------------GPMGPPGPPGPRGPQGPNG--ADGPQGPPGSVGS--VGGVGEKG 1267 Query: 1870 APADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRV 1929 P + +P + G G+ A A P + P G Sbjct: 1268 EPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPG 1327 Query: 1930 EASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPP 1973 + P P PA D E + + P + A PP PP Sbjct: 1328 DPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1371 Score = 33.1 bits (74), Expect = 4.2 Identities = 94/370 (25%), Positives = 124/370 (33%), Gaps = 98/370 (26%) Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEP 1274 AV +P +L+ GPP A P A G G++ + P PG+ P G P Sbjct: 444 AVVEPG-MLVEGPPGPAGP---------AGIMGPP--GLQG-PTGPPGDPGDRG-PPGRP 489 Query: 1275 PLALENAASLKLFAGSLAPL-LQPGAAGGEIPAVQASSGSPKARTTE------GPVDSMP 1327 L A L G++ L + G G + P + A +A + GP M Sbjct: 490 --GLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMG 547 Query: 1328 CLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 R P G ++G + + PG +G G G + G P D +G Sbjct: 548 LTGR-PGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPT-----GKPGKRGRPGADGGRG 601 Query: 1388 TSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLG 1447 G ++ GF G PG+K G P G Sbjct: 602 MPGEPGAKGDR-----GFD---------------GLPGLPGDKGHRGERG-------PQG 634 Query: 1448 PEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGE-AEISHLALQDPASDKLLGPAGLTWE 1506 P GPPG D + GE EI L A GP GL Sbjct: 635 PP----GPPGDD-----------------GMRGEDGEIGPRGLPGEA-----GPRGLLGP 668 Query: 1507 RNLPGAGVGKEMAGV--PPTLREDERPEG-PGAAWPGLEGQAYSQLERSRQELASGLPSP 1563 R PGA MAGV PP + + P+G PG PG +G Q GLP P Sbjct: 669 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGP--PGQQGNPGPQ----------GLPGP 716 Query: 1564 AATQELPVER 1573 P E+ Sbjct: 717 QGPIGPPGEK 726 >gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo sapiens] Length = 1767 Score = 79.3 bits (194), Expect = 5e-14 Identities = 202/840 (24%), Positives = 273/840 (32%), Gaps = 192/840 (22%) Query: 82 KDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPP--EGCLASPAAAPEDGPQTQSPR 139 + PQG +GP G P PP PP +G P E G Q ++ Sbjct: 879 RGPQGPQGPVGFPGPKGPPG---------------PPGKDGLPGHPGQRGETGFQGKT-- 921 Query: 140 REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPG 199 P PG + P E + G P G++ ++G + + G Sbjct: 922 ---GPPGPGGVVG-------PQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKG 970 Query: 200 MSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQG 259 +P + G+ D P G GFP +G+ Q P +G Sbjct: 971 -------DPGPQGISGK-DGPAGLR--------GFP---GERGLPGAQGAP-----GLKG 1006 Query: 260 TESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDDLEFLRACHLPRSNSG 318 E P P P P S ERG G A P L P Sbjct: 1007 GEG----------PQGP----PGPVGSPGERGSAGTAGPIGLPG---------RPGPQGP 1043 Query: 319 AAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQT 378 P E A ++ Q P G + P GLP PA AG G++ D ++ Q Sbjct: 1044 PGPAGEKGAPGEKGPQGPAGR--DGVQGPVGLPGPA--GPAGSPGEDG-DKGEIGEPGQK 1098 Query: 379 GMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPG 438 G +G K G P PV P + E P F A PG Sbjct: 1099 GSKGDKGEN----GPPGPPGLQGPVG-APGIAGGDGEPGPRGQQGMFGQKGDEGARGFPG 1153 Query: 439 SSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKG----EHPEGDPGEV-PAPS 493 + G+P E D G +G G +G + P+G PG V Sbjct: 1154 PPG--PIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGG 1211 Query: 494 PQERGEHLNTEQSHEVQPGVPPPPLPK----EQSHEVQPGAPPPPLPKAPSESARGPPGP 549 E+GE E + PG PK E+ PGA PP A+GPPG Sbjct: 1212 VGEKGE--PGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPP-------GAKGPPG- 1261 Query: 550 TDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPE 609 DG K G+ P PG P PP G+PG G+D D + Sbjct: 1262 DDGPK-------------GNPGPVGFPGD----PGPP--GEPGP-AGQDGVGGDKGEDGD 1301 Query: 610 VGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHK---LGEE 666 G+ PS +A P PP GA G EA A G P K +G + Sbjct: 1302 PGQPGPPGPSGEAGPPGPPGKRG--PPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQ 1359 Query: 667 DPVLPPVPDG-------AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESE 719 P P P+G GE +P A +G P GL ++ + E Sbjct: 1360 GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDG-------PPGPMGPPGLPGLKGDPGSKGE 1412 Query: 720 KSDFPPTPVAEVAPKAQEGE----STLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFH 775 K P + + P ++GE + G+G + P P GP Sbjct: 1413 KGH--PGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP---------- 1460 Query: 776 AGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASE-WPLLSSEK---HLQ 831 G P P + + G T + G+P PG G + P+LSS+K H + Sbjct: 1461 PGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTE 1520 Query: 832 PSQAQPETSIFDV-------------LKE-----------QAQPPENGKETSPSHPGFKD 867 QA + +I D LK+ Q P K+ SHP F D Sbjct: 1521 GMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPD 1580 Score = 70.9 bits (172), Expect = 2e-11 Identities = 183/793 (23%), Positives = 247/793 (31%), Gaps = 126/793 (15%) Query: 38 TPGSPDHRDASSIGSVGLGGFCTASESSASLDPC-LVSPEVTEPRKDPQGARGPEGSLLP 96 TPG+P G G+ G ++ P P + PQG GP+G + P Sbjct: 620 TPGAP--------GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGP 671 Query: 97 SPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPA 156 + + + +P A+ PP P + G + P P P +P Sbjct: 672 PGEKGPQGKPGLAGLPGADGPP----GHPGKEGQSGEK--GALGPPGPQGP----IGYPG 721 Query: 157 ERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPV----PLREPMKAP 212 R S G + + G K + + P P +A Sbjct: 722 PRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG 781 Query: 213 LCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLK 272 G+ G + K G P RQG P P A + + P Sbjct: 782 PTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRG 841 Query: 273 PMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQES 332 P PR S RG P P+ SG + + Sbjct: 842 QRGPT----GPRGSRGARGPTGKPG---------------PKGTSGG--DGPPGPPGERG 880 Query: 333 CQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVA 392 Q P G P G P P P G GK+ L GHP G RG Q Sbjct: 881 PQGPQG--------PVGFPGPKGPP--GPPGKDGLP-----GHP--GQRGETGFQ----G 919 Query: 393 AGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPV 452 G P G V P+ PT E P P PG++ +E G P Sbjct: 920 KTGPPGPGGVVGPQG----PTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAK--GDPG 973 Query: 453 SADAAKEVVDAGLVGLERQVSDLGSKG-------EHPEGDPGEVPAPSPQERGEHLNTEQ 505 + + AGL G + G++G E P+G PG P SP ERG Sbjct: 974 PQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPG--PVGSPGERGS------ 1025 Query: 506 SHEVQP-GVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAV 564 + P G+P P P+ PP P + + +GP GP D V Sbjct: 1026 AGTAGPIGLPGRPGPQ---------GPPGPAGEKGAPGEKGPQGPAG-----RDGVQGPV 1071 Query: 565 AKEGSRSPGDSP---GGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSD 621 G P SP G K E EP G G+ +GE+ VG + + Sbjct: 1072 GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGD-KGENGPPGPPGLQGPVGAPGI----AG 1126 Query: 622 AESRDHPSSHSAQPPRKG--GAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGE 679 + P +KG GA GP G P + GE V P P G Sbjct: 1127 GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1186 Query: 680 PTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGE 739 P P+G G+ P ++ S G+G + PP PK + GE Sbjct: 1187 PRGPQGP--NGADGPQGPPGSVGSVGGVGEKGE---PGEAGNPGPPGEAGVGGPKGERGE 1241 Query: 740 STLEIRKMGSCDGEGLLTSP--DQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALI 797 E G+ G P D P+G G P PP A G+ Sbjct: 1242 KG-EAGPPGAAGPPGAKGPPGDDGPKGNPGPVG----FPGDPGPPGEPGPAGQDGVGG-- 1294 Query: 798 LDQDQQGIPSCPG 810 D+ + G P PG Sbjct: 1295 -DKGEDGDPGQPG 1306 Score = 62.4 bits (150), Expect = 6e-09 Identities = 169/717 (23%), Positives = 230/717 (32%), Gaps = 104/717 (14%) Query: 463 AGLVGLERQVSDLGSKGEH----PEGDPGEVPAPSPQ-------ERGEHLNTEQSHEVQP 511 AG+ G ++G +GE +G+PG P PQ E+G Q Sbjct: 630 AGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP-----QGKPGLA 684 Query: 512 GVP----PPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKE 567 G+P PP P ++ + GA PP P+ P G PGP G K D + Sbjct: 685 GLPGADGPPGHPGKEGQSGEKGALGPPGPQGPI----GYPGPR-GVK-GADGVRGLKGSK 738 Query: 568 GSRSPGDSPGGKEEAPEPPDGGDPGNL--QGEDSQAFSSKRDPEVGKDELSKPSSDAESR 625 G + PG K + D G+ G + +GED R G S + + Sbjct: 739 GEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKL 798 Query: 626 DHPSSHSAQPPRKGGAGHTD-----GPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEP 680 P P R+G G T G + + +G P G+ P P GA P Sbjct: 799 GVPGL-PGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 857 Query: 681 TVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGES 740 T G G P P + +G F + PP Q GE+ Sbjct: 858 TGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPG--PPGKDGLPGHPGQRGET 915 Query: 741 TLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQ 800 + K G G G + P P G + H G P PP + L G D Sbjct: 916 GFQ-GKTGP-PGPGGVVGPQGPTGETGPIGERG-HPGPPGPPGEQGLPGAAGKEGAKGDP 972 Query: 801 DQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSP 860 QGI G +RG E+ L +Q P LK P G Sbjct: 973 GPQGISGKDGPAGLRG-------FPGERGLPGAQGAPG------LKGGEGP--QGPPGPV 1017 Query: 861 SHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLS-DTPTSSPT 919 PG + + I +P P P G++ A G E Q P G P P Sbjct: 1018 GSPGERGSAGTAGPIGLPGRPGPQGP-PGPAGEKGAPG-EKGPQGPAGRDGVQGPVGLPG 1075 Query: 920 DMVWESSLTEESELSAPTRQKLPALGEKRPEGACGD-GQSSRVSPPAAD-VLKDFSLAGN 977 S E+ + +GE +G+ GD G++ PP + +AG Sbjct: 1076 PAGPAGSPGEDGDKG--------EIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGG 1127 Query: 978 FSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMAS 1037 G+ + QQ + G + +E + PG G L GL Sbjct: 1128 --------DGEPGPRGQQGMF-----GQKGDEGARGFPG----PPGPIGLQGLPGPPGEK 1170 Query: 1038 GNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQ 1097 G G+ P P P PG Q P + G V Sbjct: 1171 GENGDVGPMGP----------------PGPPGPRGPQ-GPNGADGPQGPPGSVGSVGGVG 1213 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQG--GEAGAAETGGSAGA-GDPGKQQAPEKPG 1151 +K E + P GE+G GEAG G GA G PG PG Sbjct: 1214 EKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPG 1270 Score = 47.4 bits (111), Expect = 2e-04 Identities = 176/795 (22%), Positives = 234/795 (29%), Gaps = 177/795 (22%) Query: 1261 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE 1320 PR + P G+P K +G P PG G + P Q G P + Sbjct: 848 PRGSRGARGPTGKP--------GPKGTSGGDGPPGPPGERGPQGP--QGPVGFPGPKGPP 897 Query: 1321 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETE-------GS 1373 GP P D +P + TG + PG G +G G+ E G Sbjct: 898 GP----PGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGP 953 Query: 1374 MERMGEPSQDPKQGTSGGVD----TSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGE 1429 G P K+G G + + A L GFP E+ + GA PG Sbjct: 954 PGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPG---------ERGLPGAQGAPGL 1004 Query: 1430 KAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLAL 1489 K G G P GP G PG + A P L Sbjct: 1005 KGGEGPQG-------PPGPV----GSPGERGSAGTAGPIGL------------------- 1034 Query: 1490 QDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQL 1549 P GP G E+ PG ++ P+GP A G++G Sbjct: 1035 --PGRPGPQGPPGPAGEKGAPG----------------EKGPQGP-AGRDGVQGPV---- 1071 Query: 1550 ERSRQELASGLPSPAATQELPVERAAAFQVA-PHSHGEEAVAQDRIPSGKQHQETSACDS 1608 GLP PA P E ++ P G + + P G Sbjct: 1072 ---------GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPG----------- 1111 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 P G GP G PG + P P+ + + E G PG I Sbjct: 1112 PPGLQGP-----VGAPG-IAGGDGEPGPRGQQGMFGQKGDE-------GARGFPGPPGPI 1158 Query: 1669 LEMRNALGNQSTPAPP--TGEVADT-PLEPGKVAGAAGEAEGDITLSTAETQACASGDLP 1725 G Q P PP GE D P+ P G G Q D P Sbjct: 1159 -------GLQGLPGPPGEKGENGDVGPMGPPGPPGPRGP------------QGPNGADGP 1199 Query: 1726 EAGTTRTFSVVA-GDLVLPGSCQDPACSDKAP--GMEGTAALHGDS----PARPQQAKEQ 1778 + SV G+ PG +P +A G +G G++ A P AK Sbjct: 1200 QGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1259 Query: 1779 PGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGP------SMLPS 1832 PG + P G V P P P Q + D + +PGP + P Sbjct: 1260 PGDDGP-KGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1318 Query: 1833 VPKKDAPR----VMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDV 1888 P K P + +G G E P + P PA P G V Sbjct: 1319 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPE-GLRGIPGPV 1377 Query: 1889 VGQVSTDLIAQSISPAAAHA-------GLPPSAAEH----IVSPSAPAGDRVEASTPSCP 1937 Q Q P G P S E ++ P G++ E P Sbjct: 1378 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLP 1437 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 D P P+ P P P P+ + ST P ++ G Sbjct: 1438 GTQGSPGAKGDGG----IPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1493 Query: 1998 PVPDGPRSDSVEGSP 2012 P GP + ++ P Sbjct: 1494 PGSPGPPGEVIQPLP 1508 Score = 38.9 bits (89), Expect = 0.076 Identities = 149/644 (23%), Positives = 198/644 (30%), Gaps = 108/644 (16%) Query: 1345 EKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTG 1404 E P A +G+ AGE +G + G P +QG G TG Sbjct: 770 EDGPEGPKGRAGPTGDPGPSGQAGE-KGKLGVPGLPGYPGRQGPKGS-----------TG 817 Query: 1405 FPDFREHIAKIFEKPVLGALATPGEKAGAGR--SAVGKDLTRPLGPEKLL--DGPPGVDV 1460 FP F + + V G G++ G S + T GP+ DGPPG Sbjct: 818 FPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPG--- 874 Query: 1461 TLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAG 1520 PP + Q G P GP G + LPG + G Sbjct: 875 -----PPGERGPQGPQGPVG--------FPGPK-----GPPGPPGKDGLPGHPGQRGETG 916 Query: 1521 VPPTLREDERPEGPGAAW--PGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQ 1578 + P GPG G G+ ER G P P Q LP Sbjct: 917 ----FQGKTGPPGPGGVVGPQGPTGETGPIGERGHP----GPPGPPGEQGLP-------- 960 Query: 1579 VAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDG-PGDFAHTGVPGHVPRSTCAPSPQ 1637 + G+E D P G S D P G G PG+ G G P PQ Sbjct: 961 ---GAAGKEGAKGDPGPQG-----ISGKDGPAGLRGFPGERGLPGAQG-APGLKGGEGPQ 1011 Query: 1638 REVLTV--PEANSEPWTLDTLGGERRPGVTA--GILEMRNALGNQSTPAPPTGEVADTPL 1693 V P T +G RPG G + A G + P + P+ Sbjct: 1012 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1071 Query: 1694 E---PGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPA 1750 P AG+ GE +GD Q + GD E G + G + PG A Sbjct: 1072 GLPGPAGPAGSPGE-DGDKGEIGEPGQKGSKGDKGENGPPGPPGL-QGPVGAPGI----A 1125 Query: 1751 CSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPP-EPDETHDPKLQ 1809 D PG G + G + A+ PGP PI G + PP E E D Sbjct: 1126 GGDGEPGPRGQQGMFGQKG--DEGARGFPGPPGPI----GLQGLPGPPGEKGENGDV--- 1176 Query: 1810 HLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA 1869 GP P P P+ + +D +G G+ S + + Sbjct: 1177 ----------------GPMGPPGPPGPRGPQGPNG--ADGPQGPPGSVGS--VGGVGEKG 1216 Query: 1870 APADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRV 1929 P + +P + G G+ A A P + P G Sbjct: 1217 EPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPG 1276 Query: 1930 EASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPP 1973 + P P PA D E + + P + A PP PP Sbjct: 1277 DPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1320 Score = 33.1 bits (74), Expect = 4.2 Identities = 94/370 (25%), Positives = 124/370 (33%), Gaps = 98/370 (26%) Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEP 1274 AV +P +L+ GPP A P A G G++ + P PG+ P G P Sbjct: 393 AVVEPG-MLVEGPPGPAGP---------AGIMGPP--GLQG-PTGPPGDPGDRG-PPGRP 438 Query: 1275 PLALENAASLKLFAGSLAPL-LQPGAAGGEIPAVQASSGSPKARTTE------GPVDSMP 1327 L A L G++ L + G G + P + A +A + GP M Sbjct: 439 --GLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMG 496 Query: 1328 CLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 R P G ++G + + PG +G G G + G P D +G Sbjct: 497 LTGR-PGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPT-----GKPGKRGRPGADGGRG 550 Query: 1388 TSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLG 1447 G ++ GF G PG+K G P G Sbjct: 551 MPGEPGAKGDR-----GFD---------------GLPGLPGDKGHRGERG-------PQG 583 Query: 1448 PEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGE-AEISHLALQDPASDKLLGPAGLTWE 1506 P GPPG D + GE EI L A GP GL Sbjct: 584 PP----GPPGDD-----------------GMRGEDGEIGPRGLPGEA-----GPRGLLGP 617 Query: 1507 RNLPGAGVGKEMAGV--PPTLREDERPEG-PGAAWPGLEGQAYSQLERSRQELASGLPSP 1563 R PGA MAGV PP + + P+G PG PG +G Q GLP P Sbjct: 618 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGP--PGQQGNPGPQ----------GLPGP 665 Query: 1564 AATQELPVER 1573 P E+ Sbjct: 666 QGPIGPPGEK 675 >gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo sapiens] Length = 1806 Score = 79.3 bits (194), Expect = 5e-14 Identities = 202/840 (24%), Positives = 273/840 (32%), Gaps = 192/840 (22%) Query: 82 KDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPP--EGCLASPAAAPEDGPQTQSPR 139 + PQG +GP G P PP PP +G P E G Q ++ Sbjct: 918 RGPQGPQGPVGFPGPKGPPG---------------PPGKDGLPGHPGQRGETGFQGKT-- 960 Query: 140 REPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPG 199 P PG + P E + G P G++ ++G + + G Sbjct: 961 ---GPPGPGGVVG-------PQGPTGETGPIGERGHPGPPGPPGEQ-GLPGAAGKEGAKG 1009 Query: 200 MSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQG 259 +P + G+ D P G GFP +G+ Q P +G Sbjct: 1010 -------DPGPQGISGK-DGPAGLR--------GFP---GERGLPGAQGAP-----GLKG 1045 Query: 260 TESSAVLEKSPLKPMAPIPQDPAPRASDRERGQ-GEAPPQYLTDDLEFLRACHLPRSNSG 318 E P P P P S ERG G A P L P Sbjct: 1046 GEG----------PQGP----PGPVGSPGERGSAGTAGPIGLPG---------RPGPQGP 1082 Query: 319 AAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQT 378 P E A ++ Q P G + P GLP PA AG G++ D ++ Q Sbjct: 1083 PGPAGEKGAPGEKGPQGPAGR--DGVQGPVGLPGPA--GPAGSPGEDG-DKGEIGEPGQK 1137 Query: 379 GMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPG 438 G +G K G P PV P + E P F A PG Sbjct: 1138 GSKGDKGEN----GPPGPPGLQGPVG-APGIAGGDGEPGPRGQQGMFGQKGDEGARGFPG 1192 Query: 439 SSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKG----EHPEGDPGEV-PAPS 493 + G+P E D G +G G +G + P+G PG V Sbjct: 1193 PPG--PIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGG 1250 Query: 494 PQERGEHLNTEQSHEVQPGVPPPPLPK----EQSHEVQPGAPPPPLPKAPSESARGPPGP 549 E+GE E + PG PK E+ PGA PP A+GPPG Sbjct: 1251 VGEKGE--PGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPP-------GAKGPPG- 1300 Query: 550 TDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPE 609 DG K G+ P PG P PP G+PG G+D D + Sbjct: 1301 DDGPK-------------GNPGPVGFPGD----PGPP--GEPGP-AGQDGVGGDKGEDGD 1340 Query: 610 VGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHK---LGEE 666 G+ PS +A P PP GA G EA A G P K +G + Sbjct: 1341 PGQPGPPGPSGEAGPPGPPGKRG--PPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQ 1398 Query: 667 DPVLPPVPDG-------AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESE 719 P P P+G GE +P A +G P GL ++ + E Sbjct: 1399 GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDG-------PPGPMGPPGLPGLKGDPGSKGE 1451 Query: 720 KSDFPPTPVAEVAPKAQEGE----STLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFH 775 K P + + P ++GE + G+G + P P GP Sbjct: 1452 KGH--PGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP---------- 1499 Query: 776 AGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASE-WPLLSSEK---HLQ 831 G P P + + G T + G+P PG G + P+LSS+K H + Sbjct: 1500 PGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTE 1559 Query: 832 PSQAQPETSIFDV-------------LKE-----------QAQPPENGKETSPSHPGFKD 867 QA + +I D LK+ Q P K+ SHP F D Sbjct: 1560 GMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPD 1619 Score = 70.9 bits (172), Expect = 2e-11 Identities = 183/793 (23%), Positives = 247/793 (31%), Gaps = 126/793 (15%) Query: 38 TPGSPDHRDASSIGSVGLGGFCTASESSASLDPC-LVSPEVTEPRKDPQGARGPEGSLLP 96 TPG+P G G+ G ++ P P + PQG GP+G + P Sbjct: 659 TPGAP--------GQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGP 710 Query: 97 SPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPA 156 + + + +P A+ PP P + G + P P P +P Sbjct: 711 PGEKGPQGKPGLAGLPGADGPP----GHPGKEGQSGEK--GALGPPGPQGP----IGYPG 760 Query: 157 ERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPV----PLREPMKAP 212 R S G + + G K + + P P +A Sbjct: 761 PRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG 820 Query: 213 LCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLK 272 G+ G + K G P RQG P P A + + P Sbjct: 821 PTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRG 880 Query: 273 PMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQES 332 P PR S RG P P+ SG + + Sbjct: 881 QRGPT----GPRGSRGARGPTGKPG---------------PKGTSGG--DGPPGPPGERG 919 Query: 333 CQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVA 392 Q P G P G P P P G GK+ L GHP G RG Q Sbjct: 920 PQGPQG--------PVGFPGPKGPP--GPPGKDGLP-----GHP--GQRGETGFQ----G 958 Query: 393 AGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPV 452 G P G V P+ PT E P P PG++ +E G P Sbjct: 959 KTGPPGPGGVVGPQG----PTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAK--GDPG 1012 Query: 453 SADAAKEVVDAGLVGLERQVSDLGSKG-------EHPEGDPGEVPAPSPQERGEHLNTEQ 505 + + AGL G + G++G E P+G PG P SP ERG Sbjct: 1013 PQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPG--PVGSPGERGS------ 1064 Query: 506 SHEVQP-GVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAV 564 + P G+P P P+ PP P + + +GP GP D V Sbjct: 1065 AGTAGPIGLPGRPGPQ---------GPPGPAGEKGAPGEKGPQGPAG-----RDGVQGPV 1110 Query: 565 AKEGSRSPGDSP---GGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSD 621 G P SP G K E EP G G+ +GE+ VG + + Sbjct: 1111 GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGD-KGENGPPGPPGLQGPVGAPGI----AG 1165 Query: 622 AESRDHPSSHSAQPPRKG--GAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGE 679 + P +KG GA GP G P + GE V P P G Sbjct: 1166 GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1225 Query: 680 PTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGE 739 P P+G G+ P ++ S G+G + PP PK + GE Sbjct: 1226 PRGPQGP--NGADGPQGPPGSVGSVGGVGEKGE---PGEAGNPGPPGEAGVGGPKGERGE 1280 Query: 740 STLEIRKMGSCDGEGLLTSP--DQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALI 797 E G+ G P D P+G G P PP A G+ Sbjct: 1281 KG-EAGPPGAAGPPGAKGPPGDDGPKGNPGPVG----FPGDPGPPGEPGPAGQDGVGG-- 1333 Query: 798 LDQDQQGIPSCPG 810 D+ + G P PG Sbjct: 1334 -DKGEDGDPGQPG 1345 Score = 62.4 bits (150), Expect = 6e-09 Identities = 169/717 (23%), Positives = 230/717 (32%), Gaps = 104/717 (14%) Query: 463 AGLVGLERQVSDLGSKGEH----PEGDPGEVPAPSPQ-------ERGEHLNTEQSHEVQP 511 AG+ G ++G +GE +G+PG P PQ E+G Q Sbjct: 669 AGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP-----QGKPGLA 723 Query: 512 GVP----PPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKE 567 G+P PP P ++ + GA PP P+ P G PGP G K D + Sbjct: 724 GLPGADGPPGHPGKEGQSGEKGALGPPGPQGPI----GYPGPR-GVK-GADGVRGLKGSK 777 Query: 568 GSRSPGDSPGGKEEAPEPPDGGDPGNL--QGEDSQAFSSKRDPEVGKDELSKPSSDAESR 625 G + PG K + D G+ G + +GED R G S + + Sbjct: 778 GEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKL 837 Query: 626 DHPSSHSAQPPRKGGAGHTD-----GPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEP 680 P P R+G G T G + + +G P G+ P P GA P Sbjct: 838 GVPGL-PGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 896 Query: 681 TVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGES 740 T G G P P + +G F + PP Q GE+ Sbjct: 897 TGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPG--PPGKDGLPGHPGQRGET 954 Query: 741 TLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQ 800 + K G G G + P P G + H G P PP + L G D Sbjct: 955 GFQ-GKTGP-PGPGGVVGPQGPTGETGPIGERG-HPGPPGPPGEQGLPGAAGKEGAKGDP 1011 Query: 801 DQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSP 860 QGI G +RG E+ L +Q P LK P G Sbjct: 1012 GPQGISGKDGPAGLRG-------FPGERGLPGAQGAPG------LKGGEGP--QGPPGPV 1056 Query: 861 SHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLS-DTPTSSPT 919 PG + + I +P P P G++ A G E Q P G P P Sbjct: 1057 GSPGERGSAGTAGPIGLPGRPGPQGP-PGPAGEKGAPG-EKGPQGPAGRDGVQGPVGLPG 1114 Query: 920 DMVWESSLTEESELSAPTRQKLPALGEKRPEGACGD-GQSSRVSPPAAD-VLKDFSLAGN 977 S E+ + +GE +G+ GD G++ PP + +AG Sbjct: 1115 PAGPAGSPGEDGDKG--------EIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGG 1166 Query: 978 FSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMAS 1037 G+ + QQ + G + +E + PG G L GL Sbjct: 1167 --------DGEPGPRGQQGMF-----GQKGDEGARGFPG----PPGPIGLQGLPGPPGEK 1209 Query: 1038 GNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQ 1097 G G+ P P P PG Q P + G V Sbjct: 1210 GENGDVGPMGP----------------PGPPGPRGPQ-GPNGADGPQGPPGSVGSVGGVG 1252 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQG--GEAGAAETGGSAGA-GDPGKQQAPEKPG 1151 +K E + P GE+G GEAG G GA G PG PG Sbjct: 1253 EKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPG 1309 Score = 47.4 bits (111), Expect = 2e-04 Identities = 176/795 (22%), Positives = 234/795 (29%), Gaps = 177/795 (22%) Query: 1261 PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE 1320 PR + P G+P K +G P PG G + P Q G P + Sbjct: 887 PRGSRGARGPTGKP--------GPKGTSGGDGPPGPPGERGPQGP--QGPVGFPGPKGPP 936 Query: 1321 GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETE-------GS 1373 GP P D +P + TG + PG G +G G+ E G Sbjct: 937 GP----PGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGP 992 Query: 1374 MERMGEPSQDPKQGTSGGVD----TSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGE 1429 G P K+G G + + A L GFP E+ + GA PG Sbjct: 993 PGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPG---------ERGLPGAQGAPGL 1043 Query: 1430 KAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLAL 1489 K G G P GP G PG + A P L Sbjct: 1044 KGGEGPQG-------PPGPV----GSPGERGSAGTAGPIGL------------------- 1073 Query: 1490 QDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQL 1549 P GP G E+ PG ++ P+GP A G++G Sbjct: 1074 --PGRPGPQGPPGPAGEKGAPG----------------EKGPQGP-AGRDGVQGPV---- 1110 Query: 1550 ERSRQELASGLPSPAATQELPVERAAAFQVA-PHSHGEEAVAQDRIPSGKQHQETSACDS 1608 GLP PA P E ++ P G + + P G Sbjct: 1111 ---------GLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPG----------- 1150 Query: 1609 PHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGI 1668 P G GP G PG + P P+ + + E G PG I Sbjct: 1151 PPGLQGP-----VGAPG-IAGGDGEPGPRGQQGMFGQKGDE-------GARGFPGPPGPI 1197 Query: 1669 LEMRNALGNQSTPAPP--TGEVADT-PLEPGKVAGAAGEAEGDITLSTAETQACASGDLP 1725 G Q P PP GE D P+ P G G Q D P Sbjct: 1198 -------GLQGLPGPPGEKGENGDVGPMGPPGPPGPRGP------------QGPNGADGP 1238 Query: 1726 EAGTTRTFSVVA-GDLVLPGSCQDPACSDKAP--GMEGTAALHGDS----PARPQQAKEQ 1778 + SV G+ PG +P +A G +G G++ A P AK Sbjct: 1239 QGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1298 Query: 1779 PGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGP------SMLPS 1832 PG + P G V P P P Q + D + +PGP + P Sbjct: 1299 PGDDGP-KGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1357 Query: 1833 VPKKDAPR----VMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDV 1888 P K P + +G G E P + P PA P G V Sbjct: 1358 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPE-GLRGIPGPV 1416 Query: 1889 VGQVSTDLIAQSISPAAAHA-------GLPPSAAEH----IVSPSAPAGDRVEASTPSCP 1937 Q Q P G P S E ++ P G++ E P Sbjct: 1417 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLP 1476 Query: 1938 DPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETV 1997 D P P+ P P P P+ + ST P ++ G Sbjct: 1477 GTQGSPGAKGDGG----IPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1532 Query: 1998 PVPDGPRSDSVEGSP 2012 P GP + ++ P Sbjct: 1533 PGSPGPPGEVIQPLP 1547 Score = 38.9 bits (89), Expect = 0.076 Identities = 149/644 (23%), Positives = 198/644 (30%), Gaps = 108/644 (16%) Query: 1345 EKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTG 1404 E P A +G+ AGE +G + G P +QG G TG Sbjct: 809 EDGPEGPKGRAGPTGDPGPSGQAGE-KGKLGVPGLPGYPGRQGPKGS-----------TG 856 Query: 1405 FPDFREHIAKIFEKPVLGALATPGEKAGAGR--SAVGKDLTRPLGPEKLL--DGPPGVDV 1460 FP F + + V G G++ G S + T GP+ DGPPG Sbjct: 857 FPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPG--- 913 Query: 1461 TLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAG 1520 PP + Q G P GP G + LPG + G Sbjct: 914 -----PPGERGPQGPQGPVG--------FPGPK-----GPPGPPGKDGLPGHPGQRGETG 955 Query: 1521 VPPTLREDERPEGPGAAW--PGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQ 1578 + P GPG G G+ ER G P P Q LP Sbjct: 956 ----FQGKTGPPGPGGVVGPQGPTGETGPIGERGHP----GPPGPPGEQGLP-------- 999 Query: 1579 VAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDG-PGDFAHTGVPGHVPRSTCAPSPQ 1637 + G+E D P G S D P G G PG+ G G P PQ Sbjct: 1000 ---GAAGKEGAKGDPGPQG-----ISGKDGPAGLRGFPGERGLPGAQG-APGLKGGEGPQ 1050 Query: 1638 REVLTV--PEANSEPWTLDTLGGERRPGVTA--GILEMRNALGNQSTPAPPTGEVADTPL 1693 V P T +G RPG G + A G + P + P+ Sbjct: 1051 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1110 Query: 1694 E---PGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPA 1750 P AG+ GE +GD Q + GD E G + G + PG A Sbjct: 1111 GLPGPAGPAGSPGE-DGDKGEIGEPGQKGSKGDKGENGPPGPPGL-QGPVGAPGI----A 1164 Query: 1751 CSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPP-EPDETHDPKLQ 1809 D PG G + G + A+ PGP PI G + PP E E D Sbjct: 1165 GGDGEPGPRGQQGMFGQKG--DEGARGFPGPPGPI----GLQGLPGPPGEKGENGDV--- 1215 Query: 1810 HLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPA 1869 GP P P P+ + +D +G G+ S + + Sbjct: 1216 ----------------GPMGPPGPPGPRGPQGPNG--ADGPQGPPGSVGS--VGGVGEKG 1255 Query: 1870 APADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRV 1929 P + +P + G G+ A A P + P G Sbjct: 1256 EPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPG 1315 Query: 1930 EASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPP 1973 + P P PA D E + + P + A PP PP Sbjct: 1316 DPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1359 Score = 33.1 bits (74), Expect = 4.2 Identities = 94/370 (25%), Positives = 124/370 (33%), Gaps = 98/370 (26%) Query: 1215 AVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEP 1274 AV +P +L+ GPP A P A G G++ + P PG+ P G P Sbjct: 432 AVVEPG-MLVEGPPGPAGP---------AGIMGPP--GLQG-PTGPPGDPGDRG-PPGRP 477 Query: 1275 PLALENAASLKLFAGSLAPL-LQPGAAGGEIPAVQASSGSPKARTTE------GPVDSMP 1327 L A L G++ L + G G + P + A +A + GP M Sbjct: 478 --GLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMG 535 Query: 1328 CLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQG 1387 R P G ++G + + PG +G G G + G P D +G Sbjct: 536 LTGR-PGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPT-----GKPGKRGRPGADGGRG 589 Query: 1388 TSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLG 1447 G ++ GF G PG+K G P G Sbjct: 590 MPGEPGAKGDR-----GFD---------------GLPGLPGDKGHRGERG-------PQG 622 Query: 1448 PEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGE-AEISHLALQDPASDKLLGPAGLTWE 1506 P GPPG D + GE EI L A GP GL Sbjct: 623 PP----GPPGDD-----------------GMRGEDGEIGPRGLPGEA-----GPRGLLGP 656 Query: 1507 RNLPGAGVGKEMAGV--PPTLREDERPEG-PGAAWPGLEGQAYSQLERSRQELASGLPSP 1563 R PGA MAGV PP + + P+G PG PG +G Q GLP P Sbjct: 657 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGP--PGQQGNPGPQ----------GLPGP 704 Query: 1564 AATQELPVER 1573 P E+ Sbjct: 705 QGPIGPPGEK 714 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 78.2 bits (191), Expect = 1e-13 Identities = 446/2123 (21%), Positives = 680/2123 (32%), Gaps = 354/2123 (16%) Query: 40 GSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPP 99 G H S + G G S+ SAS PE +EP R PE + + P Sbjct: 427 GLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGLPEGSEPESSCC-PRTPEDGVDSASP 485 Query: 100 PSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERD 159 +Q + E P + PE G + +PR A D +A+ + Sbjct: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRL-TPRARSEEGASSDSSASTGSHEG 544 Query: 160 SSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLR-EPMKAPLCGEG- 217 SS P R ++E + G SP +S LR + ++A G+G Sbjct: 545 SSEWGGRPQGCPGKARAETSQQEASEG------GDPASPALSLSSLRSDDLQAETQGQGT 598 Query: 218 DQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPI 277 +Q G + G + +G +S TP ++QQG + P +P Sbjct: 599 EQATGAAVTREPLVLGLSCSWDSEGASS---TPSTCTSSQQGQRRHRSRASAMSSPSSPG 655 Query: 278 PQDPAPRASDRERGQGEAPPQYLTDDL--------EFLRACH---LPRSNSGAAPEAEVN 326 APR R + L + E RAC +PR SG++ Sbjct: 656 LGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRY-SGSSSSTRTQ 714 Query: 327 AASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPN 386 A+ + + P LP +L G S + P + + + P G G Sbjct: 715 ASG--NLRPPSSGSLPSQDL-LGTSSATVTPAVHS---DFVSGVSPHNAPSAGWAGD--- 765 Query: 387 QVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVS 446 AG + P+ P H + S + AA + + S V Sbjct: 766 ------AGSRTCSPAPIPP-----------HTSDSCSKSGAASLGEEARDTPQPSSPLVL 808 Query: 447 KAGMPVSADAAKEVVDAGLVGLER---------QVSDLGSKGEHPE-----GDPGEVPA- 491 + G P + G VG R Q + +G PE G P Sbjct: 809 QVGRP----------EQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPR 858 Query: 492 --PSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGP 549 P PQ R + S P P+E + QPG P P GP Sbjct: 859 GRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTR--QPGPTPSP-------------GP 903 Query: 550 TDGA----KVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSK 605 GA + + S +++E + G P G+EEA G P +L +A + Sbjct: 904 NSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEA----SGVSPSSLPRSSPEAVVRE 959 Query: 606 RDPEVGKDELSKPSSDAESRDHPSSHSAQPPR-KGGAGHTDGPHSQTAEADASGLPHKLG 664 + ++ + A+ + + P G H+ + A+A L Sbjct: 960 WLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSL----- 1014 Query: 665 EEDPVLPPVPDGA-----------GEPTVPEGAIWEGSGLQPKCPDTLQSREG-LGRMES 712 E DP P P+GA GE VP+GA EG P + RE G S Sbjct: 1015 EGDPGQDPEPEGALLGSSDTGPQSGE-GVPQGAAPEGVSEAP--AEAGADREAPAGCRVS 1071 Query: 713 FLTLESEKSDFPPTPVAEVAPKAQEGESTLEI-RKMG---SCDGEGLLTSPDQPRGPACD 768 L S A + K S E+ R M SC L+T C Sbjct: 1072 LRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALIT---------CL 1122 Query: 769 ASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEK 828 AS Q F E+L + Q + S + W E L S Sbjct: 1123 ASLQLFE---------EDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLW 1173 Query: 829 HLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPG------------------------ 864 L SQA P+ + + +G + S G Sbjct: 1174 ELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLK 1233 Query: 865 FKDQGADSSQIHVP--VEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMV 922 +Q DS P +E Q+ PT + + + + + + SS + + Sbjct: 1234 TSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDS-EEQRASSNLEQL 1292 Query: 923 WESSLTEESELSAPTRQKLPALGEKRPEGACGDG-QSSRVSPPAADVLKDFSLAGNFSRK 981 E+++ EE +L E+ EG G+G Q V + G + Sbjct: 1293 AENTVQEEVQL------------EETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE 1340 Query: 982 ETCCTGQGPNKSQQALADALEEGSQ--HEEACQRHPGASEAADGCSPLWGLSKREMASGN 1039 G+G + + L + E G + EE Q E +G P GL + G Sbjct: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQ----LEEVKEG--PEGGLQGEALEEGL 1394 Query: 1040 TGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQK 1099 E P + SV + + A + G +D P E +E P P + Sbjct: 1395 KEEGLP-EEGSVHGQEL-----SEASSPDGKGSQEDDPVQE--EEAGRASASAEPCPAEG 1446 Query: 1100 MECWATSDAESPKLLA-SFPSAGE-QGG---EAGAAETGGSAGAGDPGKQQAPEKPG--- 1151 E E P L+ + PSA E Q G E G + G+ G Q P + Sbjct: 1447 TE----EPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAER 1502 Query: 1152 ------EATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALL---PARELGG 1202 A L C + L E+A + L + QD L A EL Sbjct: 1503 SSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQ 1562 Query: 1203 IPRSTMDFSTH---QAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSA 1259 + ST Q + ++ PP A L QR G++ +S+ Sbjct: 1563 DVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQ---QRRHRLRGLRNLSAF 1619 Query: 1260 DPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQA------SSGS 1313 R G +G LE+ +L GS L A G E +A S S Sbjct: 1620 SERTLG-----LGPLSFTLEDEPALSTALGS---QLGEEAEGEEFCPCEACVRKKVSPMS 1671 Query: 1314 PKAR--TTEGPVDSMPCLDRMPLLAKGKQATGEE------KAATAPGAGAKASG-EGMAG 1364 PKA T GP+ L ++ +G+ GE K T P + G EG G Sbjct: 1672 PKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLG 1731 Query: 1365 DAAGETEGSME-RMGEPSQ------DPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFE 1417 + G E GE SQ DPK G + G + E+ + + H ++ Sbjct: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQER--------EGKTHNSETSA 1783 Query: 1418 KPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQ 1477 LG E+ G G S G+ + G E L G P + + + Sbjct: 1784 GSELG----EAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPE 1839 Query: 1478 LAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAG-VPPTLREDERPEGPGA 1536 GEA+ ++ P ++ G +E G P + E PE G Sbjct: 1840 AEGEAQPESEGVEAPEAE-----------------GDAQEAEGEAQPESEDVEAPEAEGE 1882 Query: 1537 AWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQV------APHSHGEEAVA 1590 A P E + E Q + G +P A +E E + + P S G EA Sbjct: 1883 AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQE 1942 Query: 1591 QDRI---PSGKQHQETSACDSPHGED----GPGDFAHTGVPGHVPRSTCAPSPQREVLTV 1643 + G+ E+ +S E+ D V + P+ E + Sbjct: 1943 AEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEA 2002 Query: 1644 PEANSEPWTLDTLGGERRPGVTA-------GILEMRNALGNQSTPAPPTGEVADTP---L 1693 PEA E + GV A E+ A P + + P Sbjct: 2003 PEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEE 2062 Query: 1694 EPGKVAGAAGEAEGDITLSTAETQAC-ASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACS 1752 E + G EAEG+ + + A A G+ G+ + P Sbjct: 2063 EAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETE 2122 Query: 1753 DKA-PGMEGTAALHGDSPARPQ----QAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPK 1807 +A P EG A + A+P+ +A++ G +P G E +E P+ Sbjct: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEG------IEAQEAEEEAQPE 2176 Query: 1808 LQHLAPEELHTDR-------ESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSP 1860 L+ + E + E+P P + +AP ++ + EG E +P Sbjct: 2177 LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE----PEGVE-TP 2231 Query: 1861 VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVS 1920 A+ QP + + + + +G ++ ++S SP P Sbjct: 2232 EAEGEAQPESEGETQGEKKGSPQVS---LGDGQSEEASESSSPVPEDRPTP--------- 2279 Query: 1921 PSAPAGDRVEASTPSCPDPAKDLSRS------SDSEEAFETPESTTP-VKAPPAPPPPPP 1973 P +P GD S P+ + S DSE ++ +P K+ P Sbjct: 2280 PPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERK 2339 Query: 1974 EVIPEPEVSTQPPPEEPGCGSET 1996 PE ST E P GS T Sbjct: 2340 ATRMYPESSTSEQEEAP-LGSRT 2361 Score = 67.0 bits (162), Expect = 3e-10 Identities = 134/574 (23%), Positives = 197/574 (34%), Gaps = 73/574 (12%) Query: 122 LASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKE 181 + +P A E P+++ AP A GD A + P E P A E QP+ Sbjct: 1835 IEAPEAEGEAQPESEGVE---APEAEGDAQEA----EGEAQPESEDVEAPEAEGEAQPES 1887 Query: 182 EGQKSSFSFSSGIDQSPGM-SPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESR 240 E ++ + +S G +P +E E + G + E E A E+ Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAA 1947 Query: 241 QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMA-------------PIPQDPAPRASD 287 Q A Q PE+ Q E A E ++ + P +D ++ Sbjct: 1948 QE-AEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006 Query: 288 RERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPV--GAYLPHAE 345 E + E Q +D +E P+S A E E E QP G P AE Sbjct: 2007 GEMQEAEEEAQPESDGVEAQ-----PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061 Query: 346 LPWGLPSPALVPEAGGSG---KEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLP 402 + V EA G E +D + +G Q G + + A G + Sbjct: 2062 EE-AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE----AEGEAQKAEGI 2116 Query: 403 VSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKA---GMPVSADAAKE 459 +PE EA P S P A+ E G ++++ +A + A A+E Sbjct: 2117 EAPETE-----GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171 Query: 460 VVDAGLVGLERQVSDLGSKGE-HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPL 518 L G+E ++ GE PE + E P E E QP + Sbjct: 2172 EAQPELEGVEAPEAE----GEAQPESEGIEAP-------------EAEGEAQPELEGVEA 2214 Query: 519 PKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGG 578 P E E QP P+A E+ G T G K S + S SP Sbjct: 2215 P-EAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273 Query: 579 KEEAPEPPD-GGD-----PGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS 632 ++ PP GGD PG+ G S SS + E D S D S+ + Sbjct: 2274 EDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGT 2333 Query: 633 AQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEE 666 RK + P S T+E + + L + E+ Sbjct: 2334 PHAERKATRMY---PESSTSEQEEAPLGSRTPEQ 2364 Score = 64.3 bits (155), Expect = 2e-09 Identities = 384/1817 (21%), Positives = 587/1817 (32%), Gaps = 318/1817 (17%) Query: 64 SSASLDPCLVSPEVT--EPRKDPQ-GARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEG 120 SSA++ P + S V+ P P G G GS SP P H S S Sbjct: 736 SSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPP--HTSDS---------- 783 Query: 121 CLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPK 180 C S AA+ + R P P++P + P E+ + P++ + Q Sbjct: 784 CSKSGAAS-----LGEEARDTPQPSSPLVLQVGRP-EQGAVGPHRSHCCSQPGTQPAQEA 837 Query: 181 EEGQKSSFSFSSG--IDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAE 238 + G S+ G P P P R ++ CG G GG P Sbjct: 838 QRGPSPEASWLCGRYCPTPPRGRPCPQR---RSSSCGS---TGSSHQSTARGPGGSPQEG 891 Query: 239 SRQGVASVQVTPEAPAA----AQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGE 294 +RQ + P + A+ A QG S + E+ L R+ +GQ E Sbjct: 892 TRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTL------------RSGGGPQGQEE 939 Query: 295 APPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPA 354 A + LPRS+ PEA V ++P+ A+ G Sbjct: 940 ASG---------VSPSSLPRSS----PEAVVREWLDNIPEEPILMTYELADETTG----- 981 Query: 355 LVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTE 414 A G G + H G+ +P Q + G P G PE +LL ++ Sbjct: 982 ----AAGGGLRGPEVDPGDDHSLEGLG--EPAQAGQQSLEGDP--GQDPEPEGALLGSSD 1033 Query: 415 EAHPASSLASFPAAQIPIAVEE-PGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVS 473 + P P V E P + + + AG VS A G V Q+ Sbjct: 1034 TGPQSGE--GVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALP-----GRVSASTQIM 1086 Query: 474 D--LGSKGEHPEGDPGEVPAPSPQERG-------EHLNTEQSHEVQPGVPPPPL-----P 519 +GSK P P EV P + L + Q E G P + P Sbjct: 1087 RALMGSKQGRPSSVP-EVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSP 1145 Query: 520 KEQ-----SHEVQPGAP--PPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSP 572 + Q S ++ PG L E P G+ ++ +P + S Sbjct: 1146 RYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISS 1205 Query: 573 GDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHS 632 G G+ P DG QG + +S + P+ E + + P+ + Sbjct: 1206 GSGGSGESSVPCAMDGTLV--TQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLN 1263 Query: 633 AQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSG 692 A+ A + D + E AS +L E V + EG EG G Sbjct: 1264 ARAC--ACATNEDEAERDSEEQRASSNLEQLAENT-----VQEEVQLEETKEGT--EGEG 1314 Query: 693 LQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDG 752 LQ + +++ G E + LE K E + Q+ E ++ ++ G Sbjct: 1315 LQEEAVQLEETKTEEGLQEEGVQLEETK---------ETEGEGQQEEEA-QLEEIEETGG 1364 Query: 753 EGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTAL-----ILDQDQQGIPS 807 EGL Q G + ++ G+ QGE L L L + Q+ S Sbjct: 1365 EGL-----QEEGVQLEEVKEGPEGGL----QGEALEEGLKEEGLPEEGSVHGQELSEASS 1415 Query: 808 CPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKD 867 G +G+ + P+ E + A+P + + +E +PP + ET PS Sbjct: 1416 PDG----KGSQEDDPVQEEEAGRASASAEPCPA--EGTEEPTEPPSHLSETDPS----AS 1465 Query: 868 QGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSL 927 + SQ+ +E T GQE Q + + + D +W S L Sbjct: 1466 ERQSGSQLEPGLEKPPG---ATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVL 1522 Query: 928 TEES--------------------------------ELSAPTRQKLPALGEKRPEGACGD 955 +++ EL Q+L ++ + G Sbjct: 1523 LKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR 1582 Query: 956 GQSSRVSPPAADVLKDFSLAG-----------NFSRKETCCTGQGPN----KSQQALADA 1000 + PP + + L N S G GP + + AL+ A Sbjct: 1583 AGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTA 1642 Query: 1001 L-----EEGSQHE----EACQRH---PGASEAADGCS--------PLWGLSKREMASGNT 1040 L EE E EAC R P + +A G + L + +R+ Sbjct: 1643 LGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTD 1702 Query: 1041 GEAPPCQP-----DSVALLDAVPCLPALAPA---SPGVTPTQDAPETEACDETQE---GR 1089 GEA P D + L P PGV +D ++ + ++ G Sbjct: 1703 GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGE 1762 Query: 1090 QQPVPAPQQKMECWATSDAESPKLLASFPSAGE---QGGEAGAAETG------GSAGAG- 1139 + Q++ S+ + L GE + GE G +G G A AG Sbjct: 1763 AEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGG 1822 Query: 1140 --DPGKQ------QAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQ 1191 DPG+ +APE GEA ++ +EA A ES E P A + Sbjct: 1823 DQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEA--E 1880 Query: 1192 DALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDS 1251 P E P + + + E PE + + L + + +E + Sbjct: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA--LETEGEDEPESEGA 1938 Query: 1252 GVKAVSSADPRAPGESP--CPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQA 1309 + A A G++ V E A E A +L ++ A GE Sbjct: 1939 EAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE------ 1992 Query: 1310 SSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAAT-APGAGAKASGEGM-AGDAA 1367 P++ E P A+G+ EE+A + G A+ EG A + Sbjct: 1993 --AQPESEDVEAPE------------AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038 Query: 1368 GET---EGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFE---KPVL 1421 GET EG + + + P+ Q A P+ + A+ E +P Sbjct: 2039 GETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPES 2098 Query: 1422 GALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKK----QQ 1477 + P E G + A G + PE + P + P Q E + Q Sbjct: 2099 EGVEAP-EAEGEAQKAEGIE-----APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQD 2152 Query: 1478 LAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAA 1537 GEA+ ++ +++ P L G + P E PE G A Sbjct: 2153 AEGEAQPESEGIEAQEAEEEAQP-------ELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205 Query: 1538 WPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSG 1597 P LEG + E Q G+ +P A E E Q GE+ + Sbjct: 2206 QPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQ------GEKKGSPQVSLGD 2259 Query: 1598 KQHQETSACDSPHGEDGPGDFAHTG--VPGHVPRSTCAPSPQREVLTVPEANSEPWTLDT 1655 Q +E S SP ED P G P P S PS R + W D+ Sbjct: 2260 GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSR-----ASSWGNCWQKDS 2314 Query: 1656 -----LGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPL---EPGKVAGAAGEAEG 1707 LG R P + + P T E + PL P + A + + Sbjct: 2315 ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQE 2374 Query: 1708 DITL-STAETQACASGD 1723 D L S A T+A D Sbjct: 2375 DQALGSLAPTEAVGRAD 2391 Score = 60.5 bits (145), Expect = 2e-08 Identities = 139/659 (21%), Positives = 218/659 (33%), Gaps = 118/659 (17%) Query: 1744 GSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCV-SSPPEPDE 1802 G QDP SD G EG A + A+P E G E P GD + + PE ++ Sbjct: 1821 GGDQDPGQSD---GAEGIEAPEAEGEAQP----ESEGVEAPEAEGDAQEAEGEAQPESED 1873 Query: 1803 THDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVA 1862 P+ + A E D E+P + P E+ GAE +P A Sbjct: 1874 VEAPEAEGEAQPE-SEDVETPEAEWEVQP-----------------ESEGAE----APEA 1911 Query: 1863 DDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPS 1922 + QP E+ ++ A G+ A A AA+ + Sbjct: 1912 EKEAQP------ETESVEALETEGE-----------DEPESEGAEAQEAEEAAQEAEGQT 1954 Query: 1923 APAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVS 1982 P + +E+ + ++ S+ EA E T + P E PE E Sbjct: 1955 QPESEVIESQ-----EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEA-PEAEGE 2008 Query: 1983 TQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDN 2042 Q EE P SD VE +P S A E + + G + D Sbjct: 2009 MQEAEEEA-----------QPESDGVEA---QPKSEGEEAQEVEGETQKTEGDAQPESDG 2054 Query: 2043 IELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGN 2102 +E + + + + + EG+ + + D+ A Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA-------------------QEAEGEAQ 2095 Query: 2103 PEAVAL-APDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE- 2160 PE+ + AP+A + T+ P + + + E P E + D E Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEG 2155 Query: 2161 SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGG 2220 P E + ++ E A+ P +E E P++ +++ AEG P G Sbjct: 2156 EAQPESEGIEAQEAEEEAQ---PELEGVEAPEAEGEAQPESE-GIEAPEAEGEAQPELEG 2211 Query: 2221 GRVQNSPPVGRKTLPLTTAPEA-GEVTPSD----SGGQEDSPAKGLSVRLEFDYSEDKSS 2275 + + PEA GE P G ++ SP L + SE S Sbjct: 2212 VEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSP 2271 Query: 2276 WDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPND-------I 2328 + PPP+ P P +RP + P + ND Sbjct: 2272 VPEDRPTPPPS------PGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRS 2325 Query: 2329 PIAKGTYTFDIDKWDDPNFNPFSSTSKMQESP---KLPQQ----SYNFDPDTCDESVDP 2380 P AK T T ++ P SSTS+ +E+P + P+Q Y+ D S+ P Sbjct: 2326 PDAKSTGTPHAER-KATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAP 2383 Score = 56.2 bits (134), Expect = 5e-07 Identities = 109/523 (20%), Positives = 180/523 (34%), Gaps = 82/523 (15%) Query: 1802 ETHDPKLQHLAPEELHTDRESPR----------PGPSMLPSVPKKDAPRVMDKVTSDETR 1851 E D + +AP + HTD S R PG S P V + + ++ D+ Sbjct: 1699 EHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDP 1758 Query: 1852 GAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLP 1911 E +A + E T + + G +G+ + + IS G Sbjct: 1759 KLGEAEGDAMAQE---------REGKTHNSETSAGSELGEAEQE--GEGISERGETGGQG 1807 Query: 1912 PSAAEHIVSPSAPAGDRVEASTPSC-----PDPAKDLSRSSDSEEAFET----------- 1955 +++ +A GD+ + P+ + S+ EA E Sbjct: 1808 SGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867 Query: 1956 -PESTTPVKAPPAPPPPPPEV--IPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEG-- 2010 PES V+AP A PE + PE + PE G + P ++SVE Sbjct: 1868 QPESED-VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926 Query: 2011 --SPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNT 2068 P S A E+ + G + + IE + + +P + D + E +V T Sbjct: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986 Query: 2069 RRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTK 2128 + ++ P S+ + + A PE+ + S G A T+ Sbjct: 1987 QEAEGEAQPESEDVEAPEAE---GEMQEAEEEAQPESDGVEAQPKSEGEE-AQEVEGETQ 2042 Query: 2129 KPRPPSLKKKQTTKKPTETPPVKETQQE---------PDEESL---------VPSGENL- 2169 K + + + P +E + E P+ E + P E + Sbjct: 2043 KTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVE 2102 Query: 2170 ASETKTESAKTEG-----------PSPALLEETPLEPAVGPKAACPLDSESAEGVVPPAS 2218 A E + E+ K EG P +E E P++ ++++ AEG P S Sbjct: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE-GVEAQDAEGEAQPES 2161 Query: 2219 GGGRVQNSPPVGRKTLPLTTAPEA-GEVTPSDSGGQEDSPAKG 2260 G Q + + L APEA GE P +S G E A+G Sbjct: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQP-ESEGIEAPEAEG 2203 Score = 32.3 bits (72), Expect = 7.1 Identities = 100/515 (19%), Positives = 161/515 (31%), Gaps = 77/515 (14%) Query: 2182 GPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAP- 2240 GP LE+ EPA+ L E+ P R + SP + T+ T P Sbjct: 1627 GPLSFTLED---EPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPI 1683 Query: 2241 --------------------EAGEVTPSDSG----------GQEDSPAKGLSVRLEFDYS 2270 EA EV P + G E GLS D Sbjct: 1684 KEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEG 1743 Query: 2271 EDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPI 2330 ED +Q+ N K+G+ M R E T A AE I Sbjct: 1744 EDGEG--SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSE----TSAGSELGEAEQEGEGI 1797 Query: 2331 AKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSS 2390 ++ T + N ++ Q+ P QS + E+ + S+ + Sbjct: 1798 SERGETGGQGSGHEDNLQGEAAAGGDQD----PGQSDGAEGIEAPEAEGEAQPESEGVEA 1853 Query: 2391 PSKSPASFEIPASAM-EANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQD 2449 P + E A E+ V+ A+ + ++T + P+ P ++ Sbjct: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEK 1913 Query: 2450 PTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETK 2509 A PET V + DE + + EA+ Q P+ + + E + Sbjct: 1914 E---AQPETESVEALETEGEDEPESEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEE 1969 Query: 2510 FSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESP-----VKSSPV 2564 +E+++ E+E E G + P+ +D +A M + +E+ V++ P Sbjct: 1970 AQPESEDVEALE-VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK 2028 Query: 2565 RMSESPTPCSGSS----------------------FEETEALVNTAAKNQHPVPRGLAPN 2602 E G + +E E V A HP + Sbjct: 2029 SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ 2088 Query: 2603 QESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEG 2637 + PE + EA G +E IE EG Sbjct: 2089 EAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEG 2123 >gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] Length = 2944 Score = 77.8 bits (190), Expect = 1e-13 Identities = 356/1568 (22%), Positives = 492/1568 (31%), Gaps = 279/1568 (17%) Query: 484 GDPG-EVPAPSPQERGEHLNTEQSHEVQPGVPPPP-LPKEQSHEVQPGAPPP-------- 533 G PG + P P ++GE ++E PG+P P P EQ PGA P Sbjct: 1430 GSPGPQGPVGPPGKKGEKGDSEDG---APGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPG 1486 Query: 534 PLPKAPSESARGPPGPT-----------DGAKVHEDSTSPAVAKEGSRSPGDSPG----- 577 PL +A + RGPPGP GAK E P ++G + PG Sbjct: 1487 PLGEAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGP-TGRQGEKGEPGRPGDPAVV 1545 Query: 578 GKEEAPEPPDGGDPGNLQGEDSQAFSSKR---------DPEVGKDELSKPSSDAESRDHP 628 G A + GD G + +R DP D + R P Sbjct: 1546 GPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGP 1605 Query: 629 SSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPP-VPDGAGEPTVPEGAI 687 S P KG G GP G + G+E P P +P AGE + GA Sbjct: 1606 PGDSGPPGEKGDPGR-PGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGL-RGAP 1663 Query: 688 WEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKM 747 + K +G + ++ + P P G E + Sbjct: 1664 GVRGPVGEKGDQGDPGEDGRNGSPGSSGPKGDRGE--PGPPGPPGRLVDTGPGAREKGEP 1721 Query: 748 GSCDGEGLLTSPDQPRGPACDASRQ-EFHAGVPHP--------PQGENLAADLGLTALIL 798 G EG P P R E G P P P GE D G L Sbjct: 1722 GDRGQEGPRGPKGDPGLPGAPGERGIEGFRGPPGPQGDPGVRGPAGEK--GDRGPPGLDG 1779 Query: 799 DQDQQGIPSCPGEGWIRGAASE--------WPLLSSEKHLQPSQAQPETSIFDVLKEQAQ 850 G P G GAA + P L E+ L P + E + Sbjct: 1780 RSGLDGKPGAAGPSGPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGPP--GLPGKPGEDGK 1837 Query: 851 PPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPT-HGGQEQALGSELQSQLPKGT 909 P NGK P PG + G + +E + P G LG + LP G Sbjct: 1838 PGLNGKNGEPGDPG--EDGRKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPGLP-GP 1894 Query: 910 LSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAAD-V 968 + P + E + Q LP GE+ G G S P D + Sbjct: 1895 VGPPGQGFPGVPGGTGPKGDRGETGSKGEQGLP--GERGLRGEPG-------SVPNVDRL 1945 Query: 969 LKDFSLAGNFSRK--ETCCTGQG-----PNKSQQALADALEEGSQHEEACQRHPGASEAA 1021 L+ + + R+ ET G P + + D+ E+G +E PG Sbjct: 1946 LETAGIKASALREIVETWDESSGSFLPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLK 2005 Query: 1022 DGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGV----TPTQDAP 1077 +A G G P P +A P +P L + GV P + Sbjct: 2006 GDRGDPGPQGPPGLALGERG---PPGPSGLAGEPGKPGIPGLPGRAGGVGEAGRPGERGE 2062 Query: 1078 ETEACDETQEGRQQP-----VPAPQQKMECWATSDAESPKLLASFPSAGEQG--GEAGA- 1129 E + ++GR P P P + D P L +GEQG G GA Sbjct: 2063 RGEKGERGEQGRDGPPGLPGTPGPPGPPGPKVSVDEPGPGL------SGEQGPPGLKGAK 2116 Query: 1130 AETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMAS 1189 E G + G G + P G+ Q + GE Sbjct: 2117 GEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGNPGLPGERGMA--------GPEGKPG 2168 Query: 1190 CQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAE 1249 Q P +GG H P L+GP A P P + G Sbjct: 2169 LQGPRGPPGPVGG----------HGDPGPPGAPGLAGP---AGPQGPSGLKGEPGETGPP 2215 Query: 1250 DSGVK----AVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGE-- 1303 G+ AV P P P G P L G + +PGA G + Sbjct: 2216 GRGLTGPTGAVGLPGPPGPSGLVGPQGSPGL-----------PGQVGETGKPGAPGRDGA 2264 Query: 1304 --IPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGA-GAKASGE 1360 + S G P + GPV P + P A G+ G PGA G K + Sbjct: 2265 SGKDGDRGSPGVPGSPGLPGPVG--PKGEPGPTGAPGQAVVG------LPGAKGEKGAPG 2316 Query: 1361 GMAGDAAGETEGSMER-----------------MGEPSQDPKQGTSGGVDTSSEQIATLT 1403 G+AGD GE +R G+P +D ++G G + + Sbjct: 2317 GLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVP 2376 Query: 1404 GFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGP--EKLLDGPPGVD-- 1459 G P + + G PG G++ ++ +P GP E+ L GPPG + Sbjct: 2377 GSPGPPGPPGVKGDLGLPGLPGAPGVVGFPGQTGPRGEMGQP-GPSGERGLAGPPGREGI 2435 Query: 1460 --VTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKE 1517 P PP + L G+ + L P ++ G G+ E PG + Sbjct: 2436 PGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGER--GEPGIRGEDGRPGQEGPRG 2493 Query: 1518 MAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAF 1577 + G P + ER E GL+G ++ + G P P + ER Sbjct: 2494 LTGPPGS--RGERGEKGDVGSAGLKG------DKGDSAVILGPPGPRGAKGDMGER---- 2541 Query: 1578 QVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDG-PGDFAHTGVPGHVPRSTCAPSP 1636 G + D+ P G + G G PGD G+PG R P Sbjct: 2542 -------GPRGLDGDKGPRG-----DNGDPGDKGSKGEPGDKGSAGLPG--LRGLLGPQG 2587 Query: 1637 QREVLTVPEANSEPWTLDTLG-----------------GERRPGVTAGILEMRNALGNQS 1679 Q +P P G GER G+ + G Sbjct: 2588 QPGAAGIPGDPGSPGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAG 2647 Query: 1680 TPAPP-----TGEVADTPLEPGKVAGAAGE-----AEGDITLSTAETQACASGDLPEAGT 1729 P P GE+ + P PG+ +GA G+ +GD + Q GD E G Sbjct: 2648 PPGRPGLAGHKGEMGE-PGVPGQ-SGAPGKEGLIGPKGD---RGFDGQPGPKGDQGEKGE 2702 Query: 1730 TRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGD 1789 T + G P+ +D + G G G P P+ + Q G P Sbjct: 2703 RGTPGI--------GGFPGPSGNDGSAGPPGPPGSVG--PRGPEGLQGQKGERGP----P 2748 Query: 1790 GKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDE 1849 G+ V +P P AP E E RPGP+ P K +A +T D+ Sbjct: 2749 GERVVGAPGVPG----------APGE---RGEQGRPGPAG-PRGEKGEA-----ALTEDD 2789 Query: 1850 TRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAG 1909 RG E S Q A P SY D G + +S A Sbjct: 2790 IRGFVRQEMSQHCACQGQFIASGSRPLP-----SYAADTAGSQLHAVPVLRVSHAEEEER 2844 Query: 1910 LPPSAAEH 1917 +PP E+ Sbjct: 2845 VPPEDDEY 2852 Score = 67.0 bits (162), Expect = 3e-10 Identities = 227/1001 (22%), Positives = 314/1001 (31%), Gaps = 183/1001 (18%) Query: 69 DPCLVSPEVTEPRKDP--------------QGARGPEGSLLPSPPPSQEREHPSSSMPFA 114 DP +V P V P+ + QG RGP G +LP P + P P Sbjct: 1541 DPAVVGPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGP--KGDPGDRGPIG 1598 Query: 115 ECPPEGCLASPAAAPED-GPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSA 173 L A P D GP P + P PG P RD V Sbjct: 1599 -------LTGRAGPPGDSGP----PGEKGDPGRPGPPGPVGPRGRDGE--------VGEK 1639 Query: 174 GRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQ--PG--------GF 223 G E P + G G+ +PG+ + P+ +GDQ PG G Sbjct: 1640 GDEGPPGDPGLPGKAG-ERGLRGAPGV---------RGPVGEKGDQGDPGEDGRNGSPGS 1689 Query: 224 ESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPI------ 277 + + PP + V + E +G E + P P AP Sbjct: 1690 SGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDPGLPGAPGERGIEG 1749 Query: 278 ------PQ-DPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQ 330 PQ DP R E+G P L+ P +GAA +A Sbjct: 1750 FRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAAGPSGPNGAAGKAG------ 1803 Query: 331 ESCQQPVGAYLPHAELPWGLPSPALVP----EAGGSGKEALDTIDVQ-GHP-QTGMRGTK 384 P LP GLP P+ P + G GK L+ + + G P + G +G K Sbjct: 1804 ----DPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEK 1859 Query: 385 PNQVVCVAAGGQ-PEG--GLP--VSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGS 439 + G P+G G P + P+ P P P P Sbjct: 1860 GDSGASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGFPGVPGGT------GPKG 1913 Query: 440 SSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEH--------PEGDPGEVPA 491 E+ SK + + + ++R + G K E +P Sbjct: 1914 DRGETGSKGEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSFLPV 1973 Query: 492 PSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTD 551 P + + + EQ + G P P E+ + G P P P + RGPPGP+ Sbjct: 1974 PERRRGPKGDSGEQGPPGKEG--PIGFPGERGLKGDRGDPGPQGPPGLALGERGPPGPSG 2031 Query: 552 GAKVHEDSTSPAV-------------------AKEGSRSP--GDSPGGKEEAPEPPDGGD 590 A P + ++G R D P G P PP Sbjct: 2032 LAGEPGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPPG 2091 Query: 591 PGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGH-----TD 645 P E S ++ P K +P S+ + P P KG G D Sbjct: 2092 PKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGD--QGPKGDRGVPGIKGDRGEPGPRGQD 2149 Query: 646 GPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSRE 705 G E +G K G + P PP P G P GA P+ P L+ Sbjct: 2150 GNPGLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEP 2209 Query: 706 G-LGRMESFLTLESEKSDF--PPTPVAEVAPKAQEG--ESTLEIRKMGSCDGEGLLTSPD 760 G G LT + PP P V P+ G E K G+ +G Sbjct: 2210 GETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGAPGRDGASGKDG 2269 Query: 761 QPRGPACDASRQEFHAGVPHP--PQGENLAADLGLTALILDQDQQGIPSCPGE----GWI 814 P S G+P P P+GE A++ G+P GE G + Sbjct: 2270 DRGSPGVPGS-----PGLPGPVGPKGEPGPTGAPGQAVV------GLPGAKGEKGAPGGL 2318 Query: 815 RGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFK-DQGADSS 873 G P ++ L + E E P E+G++ +P GFK D G Sbjct: 2319 AGDLVGEPGAKGDRGLPGPRG--EKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVP 2376 Query: 874 QIHVPVEP---QEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEE 930 P P + D LP G +G Q+ P+G + S E Sbjct: 2377 GSPGPPGPPGVKGDLGLPGLPGAPGVVGFPGQTG-PRGEMGQPGPSG-----------ER 2424 Query: 931 SELSAPTRQKLPA-LGEKRPEGACGDGQSSRVSPPAADVLK 970 P R+ +P LG P G+ G PP A LK Sbjct: 2425 GLAGPPGREGIPGPLGPPGPPGSVG--------PPGASGLK 2457 Score = 58.5 bits (140), Expect = 9e-08 Identities = 247/1044 (23%), Positives = 319/1044 (30%), Gaps = 231/1044 (22%) Query: 1038 GNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQ 1097 G+ GE P P + P LP L P SPG Q PV P Sbjct: 1403 GDRGERGPPGPGEGGIAPGEPGLPGL-PGSPGP-------------------QGPVGPPG 1442 Query: 1098 QKMECWATSDAESPKLLASFPSAGEQG--GEAGAAETGGSAG-------AGDPGKQQAPE 1148 +K E + D +P L S GEQG G GA G G AG+ G++ P Sbjct: 1443 KKGEKGDSEDG-APGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEAGEKGERGPPG 1501 Query: 1149 KPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHP--MASCQDALL-PARELGGI-P 1204 G L + G T E + P A A+ P E G + P Sbjct: 1502 PAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGEPGRPGDPAVVGPAVAGPKGEKGDVGP 1561 Query: 1205 RSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAP 1264 + Q P L+L G P + + G DP P Sbjct: 1562 AGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRP 1621 Query: 1265 GESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVD 1324 G P PVG P + K G P PG +P G A GPV Sbjct: 1622 GP-PGPVG--PRGRDGEVGEK---GDEGPPGDPG-----LPGKAGERGLRGAPGVRGPVG 1670 Query: 1325 SMPCLDRMPLLAKGKQAT-GEEKAATAPGAGAKASGEGMAGDAAG-----ETEGSMERMG 1378 KG Q GE+ +PG+ G G +T G Sbjct: 1671 E-----------KGDQGDPGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKG 1719 Query: 1379 EPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAV 1438 EP ++G G L G P E+ + G PG + G Sbjct: 1720 EPGDRGQEGPRGPKGDPG-----LPGAPG---------ERGIEGFRGPPGPQGDPG---- 1761 Query: 1439 GKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQ--DPASDK 1496 + P G EK GPPG+D R ++ K AG + + A + DP D Sbjct: 1762 ---VRGPAG-EKGDRGPPGLD--------GRSGLDGKPGAAGPSGPNGAAGKAGDPGRD- 1808 Query: 1497 LLGPAGLTWERNLPGAGVGKEMAGVP-----PTLR-EDERPEGPG----------AAWPG 1540 G GL E+ LPG + G P P L ++ P PG + G Sbjct: 1809 --GLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEKGDSGASG 1866 Query: 1541 LEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQH 1600 EG+ + ER A G+ P LP V P G V P G + Sbjct: 1867 REGRDGPKGERG----APGILGPQGPPGLPGP------VGPPGQGFPGVPGGTGPKGDRG 1916 Query: 1601 QETSACDSPHGEDG-PGDFAHTGVPGHVPR-------STCAPSPQREV-----------L 1641 + S GE G PG+ G PG VP + S RE+ L Sbjct: 1917 ETGSK-----GEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSFL 1971 Query: 1642 TVPEANSEPWTLDTLGGERRPGVTA--GILEMRNALGNQSTPAP--PTGEVADTPLEPGK 1697 VPE P G + PG G R G++ P P P G PG Sbjct: 1972 PVPERRRGP--KGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPPGLALGERGPPGP 2029 Query: 1698 VAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPG 1757 +G AGE G + +A G+ G G+ G + D PG Sbjct: 2030 -SGLAGEP-GKPGIPGLPGRAGGVGEAGRPGER-------GERGEKGERGEQG-RDGPPG 2079 Query: 1758 MEGTAALHGDSPARPQQAKEQPGPERPIPAGD-GKVCVSSPPEPDETHDPKLQHLAPEEL 1816 + GT G P P+ + ++PGP G G P + PK P + Sbjct: 2080 LPGTPGPPG--PPGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQGPKGDRGVPG-I 2136 Query: 1817 HTDRESPRP-GPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLE 1875 DR P P G P +P + RG G E P + P P Sbjct: 2137 KGDRGEPGPRGQDGNPGLPGE--------------RGMAGPEGKP---GLQGPRGPP--- 2176 Query: 1876 SPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPS 1935 P H P A + P+ P G P Sbjct: 2177 --------------------------GPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEPG 2210 Query: 1936 -CPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGS 1994 P + L T P A P PP P + P+ S P + G Sbjct: 2211 ETGPPGRGL---------------TGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGK 2255 Query: 1995 ETVPVPDGPR-SDSVEGSPFRPPS 2017 P DG D GSP P S Sbjct: 2256 PGAPGRDGASGKDGDRGSPGVPGS 2279 Score = 52.8 bits (125), Expect = 5e-06 Identities = 157/664 (23%), Positives = 216/664 (32%), Gaps = 88/664 (13%) Query: 1260 DPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGE----IPAVQASSGSPK 1315 DP PG + P + P A + F G+ PG AG P ++ S G P Sbjct: 1273 DPGLPGRTGAPGPQGPPGSATAKGERGFPGADGRPGSPGRAGNPGTPGAPGLKGSPGLPG 1332 Query: 1316 ARTTEGPVDSMPCLDRMPLLAKGKQ-ATGEEKAATAPGAGAKASGEGMAGDAAGETEGSM 1374 R G +R P KG+ A G+ PG + G +G G Sbjct: 1333 PRGDPG--------ERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSG-----PPGPR 1379 Query: 1375 ERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAG 1434 +G+P G G + G P E E + G +PG + G Sbjct: 1380 GPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQGPVG 1439 Query: 1435 RSAVGKDLTRPLGPEKLLDGPPGVDVTLLP-APPARLQVEKKQQLAGEAEISHLALQDPA 1493 + L G PG P PP + + + G L + Sbjct: 1440 PPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPG-------PLGEAG 1492 Query: 1494 SDKLLGPAGLTWERNLPGAGVGKEMAGVP-----PTLREDERPEGPGAAWPGLEGQAYSQ 1548 GP G R LPG G+ A P PT R+ E+ E P + G A + Sbjct: 1493 EKGERGPPGPAGSRGLPGV-AGRPGAKGPEGPPGPTGRQGEKGEPGRPGDPAVVGPAVAG 1551 Query: 1549 LERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDS 1608 + + ++ G P + ER V P G + DR P G + Sbjct: 1552 PKGEKGDV--GPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIG-----LTGRAG 1604 Query: 1609 PHGEDGP----GDFAHTGVPGHV-PRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPG 1663 P G+ GP GD G PG V PR ++ P P G PG Sbjct: 1605 PPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPG 1664 Query: 1664 VTAGILEM----------RNALGNQSTPAPPTGEVADTPLEPGKV--AGAAGEAEGDITL 1711 V + E RN S P GE P PG++ G +G+ Sbjct: 1665 VRGPVGEKGDQGDPGEDGRNGSPGSSGPKGDRGE-PGPPGPPGRLVDTGPGAREKGEPGD 1723 Query: 1712 STAETQACASGD--LPEAGTTRTFSVVAGDLVLPGSCQDPACSDKA--------PGMEGT 1761 E GD LP A R G PG DP A PG++G Sbjct: 1724 RGQEGPRGPKGDPGLPGAPGERGIEGFRGP---PGPQGDPGVRGPAGEKGDRGPPGLDGR 1780 Query: 1762 AALHGD----SPARPQQAKEQPG-PERP-IPAGDGKVCVSSPPEPDETHDPKLQHLAPEE 1815 + L G P+ P A + G P R +P G+ + P P P L P + Sbjct: 1781 SGLDGKPGAAGPSGPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGP-----PGL----PGK 1831 Query: 1816 LHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDET--RGAEGTESSPVADDIIQPAAPAD 1873 D + G + P P +D R +K S + G +G + A I+ P P Sbjct: 1832 PGEDGKPGLNGKNGEPGDPGEDG-RKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPG 1890 Query: 1874 LESP 1877 L P Sbjct: 1891 LPGP 1894 Score = 52.8 bits (125), Expect = 5e-06 Identities = 182/791 (23%), Positives = 243/791 (30%), Gaps = 152/791 (19%) Query: 60 TASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPE 119 T ESS S P PE K G +GP G P P + P + PP Sbjct: 1962 TWDESSGSFLPV---PERRRGPKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPP- 2017 Query: 120 GCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQP 179 G P P + P PG V AGR + Sbjct: 2018 GLALGERGPPGPSGLAGEPGKPGIPGLPG-----------------RAGGVGEAGRPGER 2060 Query: 180 KEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAP----------LCGEGDQPGGFESQEKE 229 E G+K G D PG+ P P L GE PG ++ + Sbjct: 2061 GERGEKGERG-EQGRDGPPGLPGTPGPPGPPGPKVSVDEPGPGLSGEQGPPGLKGAKGEP 2119 Query: 230 AAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPL----KPMAPIPQDP-APR 284 + G + +GV ++ P Q E+ KP P+ P P Sbjct: 2120 GSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGNPGLPGERGMAGPEGKPGLQGPRGPPGPV 2179 Query: 285 ASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAY-LPH 343 + G AP L P+ SG E P GA LP Sbjct: 2180 GGHGDPGPPGAPG---------LAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPG 2230 Query: 344 AELPWGLP----SPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEG 399 P GL SP L + G +GK D + G RG+ G P Sbjct: 2231 PPGPSGLVGPQGSPGLPGQVGETGKPGAPGRD-GASGKDGDRGSP-------GVPGSPGL 2282 Query: 400 GLPVSPEPSLLTPTEEAHPASSLASFPAAQ---------IPIAVEEPGSSSRESV-SKAG 449 PV P+ P P ++ P A+ V EPG+ + G Sbjct: 2283 PGPVGPKGE---PGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRG 2339 Query: 450 MPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEV 509 A A E D G G + G KG+ G PG P P L Sbjct: 2340 EKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPGPPGVKGDLGL------ 2393 Query: 510 QPGVPPPP----LPKEQSHEVQPGAPPP---------------PLPKAPSESARGPPG-- 548 PG+P P P + + G P P P P P GPPG Sbjct: 2394 -PGLPGAPGVVGFPGQTGPRGEMGQPGPSGERGLAGPPGREGIPGPLGPP----GPPGSV 2448 Query: 549 -PTDGAKVHEDSTSPAVAKEGSRSPGDSPG--GKEEAP--EPPDG--GDPGN-------- 593 P + + D P V G R PG G++ P E P G G PG+ Sbjct: 2449 GPPGASGLKGDKGDPGVGLPGPRGERGEPGIRGEDGRPGQEGPRGLTGPPGSRGERGEKG 2508 Query: 594 ------LQGE--DSQAFSSKRDPEVGKDELSKPSSDAESRDH-PSSHSAQPPRKGGAGHT 644 L+G+ DS P K ++ + D P + P KG G Sbjct: 2509 DVGSAGLKGDKGDSAVILGPPGPRGAKGDMGERGPRGLDGDKGPRGDNGDPGDKGSKG-- 2566 Query: 645 DGPHSQTAEADASGLPHKLGEEDPV-------LPPVPDGAGEPTVPEGAIWEGSGLQPKC 697 + + ++GLP G P +P P G+ VP G E + Sbjct: 2567 -----EPGDKGSAGLPGLRGLLGPQGQPGAAGIPGDPGSPGKDGVP-GIRGEKGDVGFMG 2620 Query: 698 PDTLQSREGLGRMESFLTLESEKSD----FPPTPVAEVAPKAQEGESTLEIRKMGSCDGE 753 P L+ G ++ L+ EK D PP K + GE + + G+ E Sbjct: 2621 PRGLKGERG---VKGACGLDGEKGDKGEAGPPGRPGLAGHKGEMGEPGVP-GQSGAPGKE 2676 Query: 754 GLLTSPDQPRG 764 GL+ P RG Sbjct: 2677 GLI-GPKGDRG 2686 Score = 50.1 bits (118), Expect = 3e-05 Identities = 304/1385 (21%), Positives = 418/1385 (30%), Gaps = 266/1385 (19%) Query: 504 EQSHEVQPGVPPPPLPKEQSHEVQPG-------APPPPLPKAPSES-ARGPPGPTDGAKV 555 + S QP P P+ + + +PG PP P P + A GP GP A Sbjct: 1235 QASFTTQPRPEPCPVYCPKGQKGEPGEMGLRGQVGPPGDPGLPGRTGAPGPQGPPGSAT- 1293 Query: 556 HEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDEL 615 A + G PG A P G PG L+G L Sbjct: 1294 -------AKGERGFPGADGRPGSPGRAGNPGTPGAPG-LKGSPG---------------L 1330 Query: 616 SKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPD 675 P D R P +P G +GP GLP + G+ P PP P Sbjct: 1331 PGPRGDPGERG-PRGPKGEPGAPGQVIGGEGP----------GLPGRKGDPGPSGPPGPR 1379 Query: 676 G-------AGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPV 728 G G P +P A+ G + + G+ E L S P PV Sbjct: 1380 GPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLP-GLPGSPGPQGPV 1438 Query: 729 AEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLA 788 K ++G+S +G P QP P G PP Sbjct: 1439 GPPGKKGEKGDSE-----------DGAPGLPGQPGSPG--------EQGPRGPPGAIGPK 1479 Query: 789 ADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQ 848 D G + + ++G PG RG P ++ + + P + K + Sbjct: 1480 GDRGFPGPLGEAGEKGERGPPGPAGSRGL----PGVAGRPGAKGPEGPPGPTGRQGEKGE 1535 Query: 849 AQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKG 908 P + P+ G K + D V P G+ G L G Sbjct: 1536 PGRPGDPAVVGPAVAGPKGEKGD-------VGPAGPRGATGVQGERGPPGLVLPGD--PG 1586 Query: 909 TLSDTPTSSPTDMVWESSLTEES----ELSAPTRQKLPALGEKRPEGACGD-GQSSRVSP 963 D P + + +S E P R P G P G G+ G+ P Sbjct: 1587 PKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPGPP--GPVGPRGRDGEVGEKGDEGP 1644 Query: 964 PAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADG 1023 P D L G + +G + + + ++G E+ PG+S Sbjct: 1645 PG-----DPGLPGKAGERGL----RGAPGVRGPVGEKGDQGDPGEDGRNGSPGSSG---- 1691 Query: 1024 CSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPAL---------APASPGVTPTQ 1074 G+ GE P P L+D P P P P Sbjct: 1692 ------------PKGDRGEPGPPGPPG-RLVDTGPGAREKGEPGDRGQEGPRGPKGDPGL 1738 Query: 1075 DAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGG 1134 E E G P P + D P L G+ G + G Sbjct: 1739 PGAPGERGIEGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAAGPSGPNGA 1798 Query: 1135 SAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDAL 1194 + AGDPG+ P GE L GE+ ++ + P + Sbjct: 1799 AGKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKG- 1857 Query: 1195 LPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVK 1254 + G R D + P L GPP + P P G G + Sbjct: 1858 -EKGDSGASGREGRDGPKGER-GAPGILGPQGPPGLPGPVGPPGQGFPGVPGGTGPKGDR 1915 Query: 1255 AV--SSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQ------PGAAGGEIPA 1306 S + PGE GEP ++ N L AG A L+ ++G +P Sbjct: 1916 GETGSKGEQGLPGERGLR-GEPG-SVPNVDRLLETAGIKASALREIVETWDESSGSFLPV 1973 Query: 1307 VQ------ASSGSPKARTTEGPVD-----------SMPCLDRMPLLAKGKQA-------T 1342 + SG EGP+ P P LA G++ Sbjct: 1974 PERRRGPKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPPGLALGERGPPGPSGLA 2033 Query: 1343 GEEKAATAPGAGAKASGEGMAGDAAGETE-GSMERMGEPSQDPKQGTSG----------- 1390 GE PG +A G G AG E G GE +D G G Sbjct: 2034 GEPGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPPGPK 2093 Query: 1391 -GVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPE 1449 VD ++ G P + K G+ G K G + D P GP Sbjct: 2094 VSVDEPGPGLSGEQGPPGLKG------AKGEPGSNGDQGPKGDRGVPGIKGDRGEP-GP- 2145 Query: 1450 KLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNL 1509 + DG PG LP E K L G + P GP G + Sbjct: 2146 RGQDGNPG-----LPGERGMAGPEGKPGLQGP--------RGPP-----GPVGGHGDPGP 2187 Query: 1510 PGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQEL 1569 PGA P L P+GP GL+G+ R GL P L Sbjct: 2188 PGA----------PGLAGPAGPQGPS----GLKGEPGETGPPGR-----GLTGPTGAVGL 2228 Query: 1570 PVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDG----PGDFAHTGVPG 1625 P + V P G + +GK D G+DG PG G+PG Sbjct: 2229 PGPPGPSGLVGP--QGSPGLPGQVGETGK--PGAPGRDGASGKDGDRGSPGVPGSPGLPG 2284 Query: 1626 HV-PRSTCAP--SPQREVLTVPEANSEPWTLDTLGGERRPGVTAG-ILEMRNALGNQSTP 1681 V P+ P +P + V+ +P A E + PG AG ++ A G++ P Sbjct: 2285 PVGPKGEPGPTGAPGQAVVGLPGAKGE---------KGAPGGLAGDLVGEPGAKGDRGLP 2335 Query: 1682 APPTGEVADTPLEPGKVAGAAGEA--EGDITLSTAETQACASGD----LPEAGTTRTFSV 1735 P GE + AG AGE G+ A GD +P + Sbjct: 2336 G-PRGEKGE--------AGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPGPPG 2386 Query: 1736 VAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVS 1795 V GDL LPG PG G G + R + + P ER + G+ + Sbjct: 2387 VKGDLGLPG----------LPGAPGVVGFPGQTGPRGEMGQPGPSGERGLAGPPGREGIP 2436 Query: 1796 SPPEP 1800 P P Sbjct: 2437 GPLGP 2441 Score = 45.8 bits (107), Expect = 6e-04 Identities = 170/710 (23%), Positives = 221/710 (31%), Gaps = 151/710 (21%) Query: 81 RKDPQGARGPEGSLLPSPP-PSQEREHPSSSMPFAECPP--EGCLASPAAAPEDGPQ--- 134 R P G G G P PP P + P + + PP +G P + + GP+ Sbjct: 2074 RDGPPGLPGTPGP--PGPPGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQGPKGDR 2131 Query: 135 ----TQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKS---- 186 + R EP P D P ER AG E +P +G + Sbjct: 2132 GVPGIKGDRGEPGPRGQ-DGNPGLPGERGM------------AGPEGKPGLQGPRGPPGP 2178 Query: 187 -SFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPG--GFESQEKEAAGGFPPAESRQGV 243 G +PG++ P + L GE + G G A G P G+ Sbjct: 2179 VGGHGDPGPPGAPGLAG-PAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGPPGPSGL 2237 Query: 244 ASVQVTPEAPAAAQQ-------GTESSAVLEKSPLKPMAP-IPQDPAPRASDRERGQGEA 295 Q +P P + G + ++ + P P P P P E G A Sbjct: 2238 VGPQGSPGLPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGA 2297 Query: 296 PPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSP-A 354 P Q + LP GA E A VG P A+ GLP P Sbjct: 2298 PGQAVVG---------LP----GAKGE---KGAPGGLAGDLVGE--PGAKGDRGLPGPRG 2339 Query: 355 LVPEAGGSGKEALDTIDVQ-GHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPT 413 EAG +G+ D Q G P G +G K + V V P G P + L P Sbjct: 2340 EKGEAGRAGEPGDPGEDGQKGAP--GPKGFKGDPGVGVPGSPGPPG--PPGVKGDLGLPG 2395 Query: 414 EEAHPASSLASFPAAQIPIA-VEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQV 472 P + FP P + +PG S + AG P + G G Sbjct: 2396 LPGAPG--VVGFPGQTGPRGEMGQPGPSGERGL--AGPPGREGIPGPLGPPGPPGSVGPP 2451 Query: 473 SDLGSKGEHPEGDPGEVPAPSPQ-ERGEH-LNTEQSHEVQPG----VPPPPLPKEQSHEV 526 G KG+ +GDPG V P P+ ERGE + E Q G PP E+ + Sbjct: 2452 GASGLKGD--KGDPG-VGLPGPRGERGEPGIRGEDGRPGQEGPRGLTGPPGSRGERGEKG 2508 Query: 527 QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAV--AKEGSRSPGDSPGGKEEAPE 584 G+ K S GPPGP GAK P +G R PG K E Sbjct: 2509 DVGSAGLKGDKGDSAVILGPPGPR-GAKGDMGERGPRGLDGDKGPRGDNGDPGDKGSKGE 2567 Query: 585 PPDGG------------------------DPGN-----------------------LQGE 597 P D G DPG+ L+GE Sbjct: 2568 PGDKGSAGLPGLRGLLGPQGQPGAAGIPGDPGSPGKDGVPGIRGEKGDVGFMGPRGLKGE 2627 Query: 598 DSQAFSSKRDPEVG----------------KDELSKPSSDAESRDHPSSHSAQPPRKGGA 641 + D E G K E+ +P +S P G Sbjct: 2628 RGVKGACGLDGEKGDKGEAGPPGRPGLAGHKGEMGEPGVPGQSGAPGKEGLIGPKGDRGF 2687 Query: 642 GHTDGPHSQTAEADA------SGLPHKLGEEDPVLPPVPDGAGEPTVPEG 685 GP E G P G + PP P G+ P PEG Sbjct: 2688 DGQPGPKGDQGEKGERGTPGIGGFPGPSGNDGSAGPPGPPGSVGPRGPEG 2737 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.306 0.126 0.365 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 150,170,986 Number of Sequences: 37866 Number of extensions: 9745946 Number of successful extensions: 78125 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 409 Number of HSP's successfully gapped in prelim test: 2770 Number of HSP's that attempted gapping in prelim test: 35573 Number of HSP's gapped (non-prelim): 30249 length of query: 2948 length of database: 18,247,518 effective HSP length: 120 effective length of query: 2828 effective length of database: 13,703,598 effective search space: 38753775144 effective search space used: 38753775144 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 43 (22.0 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.