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Search of human proteins with 150418005
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
(1174 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 2382 0.0
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 1222 0.0
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 194 3e-49
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 179 1e-44
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 174 3e-43
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 174 3e-43
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 174 3e-43
gi|109138573 protein tyrosine phosphatase, non-receptor type 20A... 173 8e-43
gi|109138561 protein tyrosine phosphatase, non-receptor type 20A... 173 8e-43
gi|109138557 protein tyrosine phosphatase, non-receptor type 20A... 173 8e-43
gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ... 173 8e-43
gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ... 173 8e-43
gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ... 173 8e-43
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 173 1e-42
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 173 1e-42
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 173 1e-42
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 173 1e-42
gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Ho... 172 2e-42
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 171 4e-42
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 171 4e-42
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 171 4e-42
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 171 4e-42
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 171 4e-42
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 169 2e-41
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 169 2e-41
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo
sapiens]
Length = 1174
Score = 2382 bits (6172), Expect = 0.0
Identities = 1174/1174 (100%), Positives = 1174/1174 (100%)
Query: 1 MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE 60
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE
Sbjct: 1 MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE 60
Query: 61 VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY 120
VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY
Sbjct: 61 VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY 120
Query: 121 YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV 180
YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
Sbjct: 121 YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV 180
Query: 181 LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG 240
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG
Sbjct: 181 LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG 240
Query: 241 IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR 300
IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR
Sbjct: 241 IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR 300
Query: 301 HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD 360
HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD
Sbjct: 301 HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD 360
Query: 361 NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS 420
NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS
Sbjct: 361 NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS 420
Query: 421 ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS 480
ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS
Sbjct: 421 ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS 480
Query: 481 YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP 540
YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP
Sbjct: 481 YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP 540
Query: 541 ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH 600
ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH
Sbjct: 541 ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH 600
Query: 601 HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS 660
HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS
Sbjct: 601 HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS 660
Query: 661 AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE 720
AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE
Sbjct: 661 AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE 720
Query: 721 EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT 780
EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT
Sbjct: 721 EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT 780
Query: 781 AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK 840
AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK
Sbjct: 781 AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK 840
Query: 841 KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY 900
KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY
Sbjct: 841 KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY 900
Query: 901 ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV 960
ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV
Sbjct: 901 ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV 960
Query: 961 SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT 1020
SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT
Sbjct: 961 SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT 1020
Query: 1021 VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY 1080
VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY
Sbjct: 1021 VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY 1080
Query: 1081 LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL 1140
LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL
Sbjct: 1081 LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL 1140
Query: 1141 DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI 1174
DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI
Sbjct: 1141 DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI 1174
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
sapiens]
Length = 1187
Score = 1222 bits (3161), Expect = 0.0
Identities = 658/1216 (54%), Positives = 870/1216 (71%), Gaps = 73/1216 (6%)
Query: 3 LPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVT 62
+PFGLKL+RTRRY V SK+C V RI+LL++ +E TLSVESTGQE LEAVAQRLELRE
Sbjct: 1 MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH 60
Query: 63 YFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYL 122
YF LW+ +K Q RWV+LEKPLKK LDK+A EP ++FGV+FYVP+VS LQQE TRYQYYL
Sbjct: 61 YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL 120
Query: 123 QLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLE 182
Q+KKD+LEG + CTL+Q I+LAGLAVQADFGD++Q++SQDFL+++ LFP+ +E VLE
Sbjct: 121 QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE 180
Query: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242
E TQKVA H+ + G+ +AE++Y+ EVER+DG+G+E +P KD+ G+ + +G GIF
Sbjct: 181 ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF 240
Query: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHK 302
V+++ GR V++RW+D+ N++HNKS +EL NKEET F T+D+E AKYI RL RHK
Sbjct: 241 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK 300
Query: 303 FYRLNQCNLQTQTVTVNPIRRRSS-SRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDN 361
FY+ N+ + Q+ + PIRR+ + SR SLP+ QPY++ PP + HY+E + +SQD+
Sbjct: 301 FYKQNKICTE-QSNSPPPIRRQPTWSRSSLPRQQPYIL-PPVHVQCGEHYSETH-TSQDS 357
Query: 362 LFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSI 421
+F N+ YC+S SLD LNG + NGSV S HS NSLN Q ++Q SP+SSN SI
Sbjct: 358 IFHGNEEALYCNSHNSLDLNY--LNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSI 415
Query: 422 TGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSY 481
GSD+MR DY+PSHRHSA+I PSYRPTPDYETVM+Q+ RG++H + QS SLRNLNI +++
Sbjct: 416 PGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTH 475
Query: 482 AYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAER----RPVVGA- 536
AY++P LVYSQPE+RE P + S SPS P +P A
Sbjct: 476 AYNQPEDLVYSQPEMRERHPYTVPYGPQGVY--SNKLVSPSDQRNPKNNVVPSKPGASAI 533
Query: 537 ---VSVPELTNAQLQ-AQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLS--RHLYISSS 590
VS PEL N QLQ + +Y + ++++ ++RPPPPYP PRPA STPDL+ RH Y+S S
Sbjct: 534 SHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGS 593
Query: 591 NPDLITRRVHHSVQTFQEDSLPVAH-SLQEVSEPLTAAR-HAQLHKRNSIEVA-GLSHGL 647
+PDL+TR+V SV+TFQEDS PV H SLQEVSEPLTA + H ++KR+S+EV + G+
Sbjct: 594 SPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGM 653
Query: 648 EGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREG-PEEAEGL-------RYGHKK 699
E + LK L P + +G PEE G +Y HKK
Sbjct: 654 EAMTLKSLHL-----------------PMARRNTLREQGPPEEGSGSHEVPQLPQYHHKK 696
Query: 700 SLSDATMLIHSSEEEEDEDFEEESGARAPPARAR-----EPRPGLAQDP-------PGCP 747
+ SDATMLIHSSE EE+E+ ES + P R + + + LA+ P PG
Sbjct: 697 TFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPR 756
Query: 748 RVLLAGPLHILEPKAHVPD--AEKRMMDSSPVR--TTAEAQRPWRDGL-LMPSMSESDLT 802
+ + G L + +A +P A R++ P + + + P +G L PS+SE DL
Sbjct: 757 KSVSNGALR--QDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDL- 813
Query: 803 TSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTR---VDAKKIGPLKLAALNG 859
TS + R +++ +K+RPVS++ S + +I+E + ++K + ++A+K PL LAALNG
Sbjct: 814 TSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQK-RPLMLAALNG 872
Query: 860 LSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLP 919
LS++RV +E + ATR DER + L+++LE+GMVFTEYE+I KK+ +G STA LP
Sbjct: 873 LSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKK-ANGIFSTAALP 931
Query: 920 ENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQ 979
ENAER+R ++V+PY++ RVEL+PTKENNTGYINASHIKV V G EW YIATQGPL +TC
Sbjct: 932 ENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCH 991
Query: 980 DFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCY 1039
DFWQMVWEQG+ +IAMVTAEEEGGR KS RYWP+LGS+H++ TYG+FK+TT+FRTDS CY
Sbjct: 992 DFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCY 1051
Query: 1040 ATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSD-PQ 1098
ATTGLK+KHLL+GQERTVWHLQYTDWP+HGCPED++GFLSYLEEIQSVRRHTNS + +
Sbjct: 1052 ATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTK 1111
Query: 1099 SPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYT 1158
+ +PP++VHCSAGVGRTGV+ILSE+MI CLEHNE +++P +L +LR+QRM ++QT+ QY
Sbjct: 1112 NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYK 1171
Query: 1159 FVYRVLIQFLKSSRLI 1174
FVY+VLIQFL++SRLI
Sbjct: 1172 FVYQVLIQFLQNSRLI 1187
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 305 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 358
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 359 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 418
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 419 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 475
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 476 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 525
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 526 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 568
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 350 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 403
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 404 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 463
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 464 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 520
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 521 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 570
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 571 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 613
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 461 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 514
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 515 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 574
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 575 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 632 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 681
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 682 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724
Score = 82.0 bits (201), Expect = 3e-15
Identities = 81/321 (25%), Positives = 135/321 (42%), Gaps = 44/321 (13%)
Query: 127 DILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----E 182
DI EG + C L A+ LA AVQ+ FGD++ ++ G+L D + E
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNE 51
Query: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242
+ KV LH+++ GL +AE Y+ +D YG E + +D D+ IG G+
Sbjct: 52 DFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVA 111
Query: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLC 297
V ++ + W +I +S + F + + ++E + F + + K +W+ C
Sbjct: 112 V-YRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSC 170
Query: 298 VARHKFYRLNQCNLQTQTVTVN--PIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPY 355
V H F++ + Q + V + R++ + S P+L + +P
Sbjct: 171 VEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRS------------PRLRH--EIRKPR 216
Query: 356 ASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTN----SLNNP-QPYL 410
SS DNL N+ Y ++ + L + + V S + S NNP Q YL
Sbjct: 217 HSSADNL--ANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYL 274
Query: 411 -QPSPMSSNPSITGSDVMRPD 430
Q S S +PS PD
Sbjct: 275 TQKSSSSVSPSSNAPGSCSPD 295
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 506 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 559
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 560 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 619
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 620 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 676
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 677 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 726
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 727 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 769
Score = 85.5 bits (210), Expect = 3e-16
Identities = 89/352 (25%), Positives = 140/352 (39%), Gaps = 61/352 (17%)
Query: 127 DILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----E 182
DI EG + C L A+ LA AVQ+ FGD++ ++ G+L D + E
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNE 51
Query: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242
+ KV LH+++ GL +AE Y+ +D YG E + +D D+ IG G+
Sbjct: 52 DFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVA 111
Query: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLC 297
V ++ + W +I +S + F + + ++E + F + + K +W+ C
Sbjct: 112 V-YRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSC 170
Query: 298 VARHKFYRLNQC-----NLQTQTVTV-----------------------NPIRRRSSS-- 327
V H F++ + N+ +Q T+ NP RRS S
Sbjct: 171 VEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVE 230
Query: 328 ---RMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQID 384
SLP P + P +P SS DNL N+ Y ++ +
Sbjct: 231 HLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNL--ANEMTYITETEDVFYTYKGS 288
Query: 385 LNGRIRNGSVYSAHSTN----SLNNP-QPYL-QPSPMSSNPSITGSDVMRPD 430
L + + V S + S NNP Q YL Q S S +PS PD
Sbjct: 289 LAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 340
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 592 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 645
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 646 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 705
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 706 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 762
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 763 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 812
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 813 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 855
Score = 139 bits (350), Expect = 2e-32
Identities = 118/430 (27%), Positives = 196/430 (45%), Gaps = 46/430 (10%)
Query: 19 SKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQ-NQRRW 77
++S ++ I L+ F ++ + TGQ L+ V L + E YF L + + + RW
Sbjct: 25 TRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRW 84
Query: 78 VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137
++ K ++KQL K T++F V F++P + LQQE TR+ Y+LQLK DI EG + C L
Sbjct: 85 LEASKAIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
Query: 138 EQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----EEATQKVALLHQ 193
A+ LA AVQ+ FGD++ ++ G+L D + E+ KV LH+
Sbjct: 144 NSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNEDFLTKVESLHE 193
Query: 194 KYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVV 253
++ GL +AE Y+ +D YG E + +D D+ IG G+ V ++
Sbjct: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAV-YRKYICTSF 252
Query: 254 FRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308
+ W +I +S + F + + ++E + F + + K +W+ CV H F++ +
Sbjct: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
Query: 309 CNLQTQTVTVN--PIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPN 366
Q + V + R++ + S P+L + +P SS DNL N
Sbjct: 313 LLPQEKNVLSQYWTMGSRNTKKRS------------PRLRH--EIRKPRHSSADNL--AN 356
Query: 367 QNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTN----SLNNP-QPYL-QPSPMSSNPS 420
+ Y ++ + L + + V S + S NNP Q YL Q S S +PS
Sbjct: 357 EMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPS 416
Query: 421 ITGSDVMRPD 430
PD
Sbjct: 417 SNAPGSCSPD 426
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 194 bits (494), Expect = 3e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 637 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 690
Query: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 691 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 750
Query: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 751 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 807
Query: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 808 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 857
Query: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 858 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 900
Score = 142 bits (359), Expect = 1e-33
Identities = 126/461 (27%), Positives = 201/461 (43%), Gaps = 63/461 (13%)
Query: 19 SKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQ-NQRRW 77
++S ++ I L+ F ++ + TGQ L+ V L + E YF L + + + RW
Sbjct: 25 TRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRW 84
Query: 78 VDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTL 137
++ K ++KQL K T++F V F++P + LQQE TR+ Y+LQLK DI EG + C L
Sbjct: 85 LEASKAIRKQL-KGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
Query: 138 EQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----EEATQKVALLHQ 193
A+ LA AVQ+ FGD++ ++ G+L D + E+ KV LH+
Sbjct: 144 NSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNEDFLTKVESLHE 193
Query: 194 KYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVV 253
++ GL +AE Y+ +D YG E + +D D+ IG G+ V ++
Sbjct: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAV-YRKYICTSF 252
Query: 254 FRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308
+ W +I +S + F + + ++E + F + + K +W+ CV H F++ +
Sbjct: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
Query: 309 C-----NLQTQTVTV-----------------------NPIRRRSSS-----RMSLPKPQ 335
N+ +Q T+ NP RRS S SLP
Sbjct: 313 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS 372
Query: 336 PYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVY 395
P + P +P SS DNL N+ Y ++ + L + + V
Sbjct: 373 PPITPNWRSPRLRHEIRKPRHSSADNL--ANEMTYITETEDVFYTYKGSLAPQDSDSEVS 430
Query: 396 SAHSTN----SLNNP-QPYL-QPSPMSSNPSITGSDVMRPD 430
S + S NNP Q YL Q S S +PS PD
Sbjct: 431 QNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 471
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 179 bits (454), Expect = 1e-44
Identities = 97/282 (34%), Positives = 158/282 (56%), Gaps = 19/282 (6%)
Query: 887 LEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEN 946
L + L G V T+++++ +K+ S A+LP+N +NR++D+ PYD RV L +
Sbjct: 646 LAEGLITGTVLTQFDQLYRKK-PGMTMSCAKLPQNISKNRYRDISPYDATRVIL----KG 700
Query: 947 NTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
N YINA++I + + S I YIA QGPL +TC DFWQM WEQG +++ M+T + E GR
Sbjct: 701 NEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGR 760
Query: 1005 EKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTD 1064
K +YWP + +YG +++T + Y + + + + R + +QY
Sbjct: 761 VKCHQYWP---EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817
Query: 1065 WPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIM 1124
WP+HG P+D FL ++ +++ R P++VHCSAG+GRTGV+I E
Sbjct: 818 WPDHGVPDDSSDFLDFVCHVRNKR---------AGKEEPVVVHCSAGIGRTGVLITMETA 868
Query: 1125 IACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
+ +E N+ + ++ +R QR M++QT QY FV +++
Sbjct: 869 MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK 910
Score = 157 bits (398), Expect = 4e-38
Identities = 100/308 (32%), Positives = 161/308 (52%), Gaps = 21/308 (6%)
Query: 8 KLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLW 67
+L R R++T +V I LL+N F ++ GQ L+ V + L+L E YF L
Sbjct: 19 ELARDRQHTE-----VVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQ 73
Query: 68 YYNKQNQR-RWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKK 126
+ RW+D KP++KQL K ++ F V F+V ++LQ+E TRYQY+LQ+K+
Sbjct: 74 LADDSTDNPRWLDPNKPIRKQL-KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQ 132
Query: 127 DILEGSIPCTLEQAIQLAGLAVQADFGDFDQYES-QDFLQKFALFPVGWLQDEKVLEEAT 185
DIL G +PC A LA AVQ++ GD+DQ E+ +L ++ P ++
Sbjct: 133 DILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIP-------NQPQDFE 185
Query: 186 QKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKH 245
+++A LHQ++ GL+ +AE Y+ ++ YG E + A+D ++I IG GI + +
Sbjct: 186 KEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILI-Y 244
Query: 246 KNGRHPVVFRWHDIANMSHNKSFFALEL-----ANKEETIQFQTEDMETAKYIWRLCVAR 300
KN F W I +S F ++L ++E + F + K +W+ CV
Sbjct: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304
Query: 301 HKFYRLNQ 308
H F+RL++
Sbjct: 305 HTFFRLDR 312
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6 isoform
3 [Homo sapiens]
Length = 624
Score = 174 bits (442), Expect = 3e-43
Identities = 96/263 (36%), Positives = 149/263 (56%), Gaps = 19/263 (7%)
Query: 919 PENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWD---YIATQGP 973
PEN +NR++++LP+D RV L N G YINA++IK + G + + YIA+QG
Sbjct: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L+ T DFWQM W++ +I M T E E GR K YWP +G + YG + +T
Sbjct: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQR---AYGPYSVTNCGE 384
Query: 1034 TDSGCYATTGLKMKHLLTGQ-ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTN 1092
D+ Y L++ L G R +WH QY WP+HG P + G LS+L++I N
Sbjct: 385 HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------N 437
Query: 1093 STSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMM 1149
+ P++VHCSAG+GRTG +I+ ++++ + + +DI + + M+R QR
Sbjct: 438 QRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG 497
Query: 1150 LVQTLCQYTFVYRVLIQFLKSSR 1172
+VQT QY F+Y + QF+++++
Sbjct: 498 MVQTEAQYKFIYVAIAQFIETTK 520
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6 isoform
1 [Homo sapiens]
Length = 595
Score = 174 bits (442), Expect = 3e-43
Identities = 96/263 (36%), Positives = 149/263 (56%), Gaps = 19/263 (7%)
Query: 919 PENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWD---YIATQGP 973
PEN +NR++++LP+D RV L N G YINA++IK + G + + YIA+QG
Sbjct: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L+ T DFWQM W++ +I M T E E GR K YWP +G + YG + +T
Sbjct: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQR---AYGPYSVTNCGE 384
Query: 1034 TDSGCYATTGLKMKHLLTGQ-ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTN 1092
D+ Y L++ L G R +WH QY WP+HG P + G LS+L++I N
Sbjct: 385 HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------N 437
Query: 1093 STSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMM 1149
+ P++VHCSAG+GRTG +I+ ++++ + + +DI + + M+R QR
Sbjct: 438 QRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG 497
Query: 1150 LVQTLCQYTFVYRVLIQFLKSSR 1172
+VQT QY F+Y + QF+++++
Sbjct: 498 MVQTEAQYKFIYVAIAQFIETTK 520
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6 isoform
2 [Homo sapiens]
Length = 597
Score = 174 bits (442), Expect = 3e-43
Identities = 96/263 (36%), Positives = 149/263 (56%), Gaps = 19/263 (7%)
Query: 919 PENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWD---YIATQGP 973
PEN +NR++++LP+D RV L N G YINA++IK + G + + YIA+QG
Sbjct: 270 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 329
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L+ T DFWQM W++ +I M T E E GR K YWP +G + YG + +T
Sbjct: 330 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQR---AYGPYSVTNCGE 386
Query: 1034 TDSGCYATTGLKMKHLLTGQ-ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTN 1092
D+ Y L++ L G R +WH QY WP+HG P + G LS+L++I N
Sbjct: 387 HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-------N 439
Query: 1093 STSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMM 1149
+ P++VHCSAG+GRTG +I+ ++++ + + +DI + + M+R QR
Sbjct: 440 QRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG 499
Query: 1150 LVQTLCQYTFVYRVLIQFLKSSR 1172
+VQT QY F+Y + QF+++++
Sbjct: 500 MVQTEAQYKFIYVAIAQFIETTK 522
>gi|109138573 protein tyrosine phosphatase, non-receptor type 20A
isoform 8 [Homo sapiens]
Length = 339
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 67 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 125
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 126 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 181
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 182 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 234
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 235 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 283
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 284 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333
>gi|109138561 protein tyrosine phosphatase, non-receptor type 20A
isoform 3 [Homo sapiens]
Length = 411
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 139 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 197
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 198 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 253
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 254 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 306
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 307 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 355
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 356 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405
>gi|109138557 protein tyrosine phosphatase, non-receptor type 20A
isoform 1 [Homo sapiens]
Length = 420
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 148 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 206
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 207 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 262
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 263 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 315
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 316 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 364
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 365 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414
>gi|108802617 protein tyrosine phosphatase, non-receptor type 20
isoform 8 [Homo sapiens]
Length = 339
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 67 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 125
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 126 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 181
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 182 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 234
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 235 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 283
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 284 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 333
>gi|108802607 protein tyrosine phosphatase, non-receptor type 20
isoform 3 [Homo sapiens]
Length = 411
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 139 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 197
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 198 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 253
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 254 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 306
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 307 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 355
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 356 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 405
>gi|108802604 protein tyrosine phosphatase, non-receptor type 20
isoform 1 [Homo sapiens]
Length = 420
Score = 173 bits (439), Expect = 8e-43
Identities = 104/290 (35%), Positives = 156/290 (53%), Gaps = 28/290 (9%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
KILE++ + E+ + K L GE ++ P N E+NR++D+LPYD RV L +K
Sbjct: 148 KILEEKTAAYDIMQEFMALELKNL-PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK 206
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ YINAS+I++ G E+ YIATQGPL +T DFWQMV E +IAM+T E EGG
Sbjct: 207 D----YINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGI 262
Query: 1005 EKSFRYWP-----RLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWH 1059
K + YWP L +H V ++I F ++ TG +V
Sbjct: 263 IKCYHYWPISLKKPLELKHFRVFLENYQILQYF-------IIRMFQVVEKSTGTSHSVKQ 315
Query: 1060 LQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVI 1119
LQ+T WP+HG P F+ Y+ R ++ T P++VHCSAG+GRTGV +
Sbjct: 316 LQFTKWPDHGTPASADSFIKYIR----YARKSHLTG-------PMVVHCSAGIGRTGVFL 364
Query: 1120 LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK 1169
+++ + N +I ++ +R+QR +VQT QY F Y ++++ L+
Sbjct: 365 CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR 414
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 173 bits (438), Expect = 1e-42
Identities = 98/287 (34%), Positives = 156/287 (54%), Gaps = 23/287 (8%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
++L L+QG+ E E + + + +D +C + EN +NR++++LPYD RV L
Sbjct: 2207 RVLRGLLDQGIPSKELENLQELKPLD-QCLIGQTKENRRKNRYKNILPYDATRVPL---- 2261
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ GYINAS IK+ V E+ YIA QGPL T DFWQM+WEQ +IAM+T E EG +
Sbjct: 2262 GDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEK 2321
Query: 1005 EKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTD 1064
K RYWP + + T+ R ++ + + ++ + T + R + HL +T
Sbjct: 2322 IKCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2380
Query: 1065 WPEHGC---PEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILS 1121
WP+H P+DL F+SY+ I + P++ HCSAG+GR+G +I
Sbjct: 2381 WPDHDTPSQPDDLLTFISYMRHIHR--------------SGPIITHCSAGIGRSGTLICI 2426
Query: 1122 EIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL 1168
++++ + + DI ++ +R QR +VQT QY F Y+V++ L
Sbjct: 2427 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2473
Score = 112 bits (280), Expect = 2e-24
Identities = 88/313 (28%), Positives = 153/313 (48%), Gaps = 28/313 (8%)
Query: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVD------- 79
I LLN + +E T ++ ++ + V + L E F+L K N+ +VD
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATL-KDNEYFFVDPDLKLTK 634
Query: 80 ------LEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSI 133
E+P KK K + T++F + F++ VS +Q +T +QYYLQL+KDILE +
Sbjct: 635 VAPEGWKEEPKKKT--KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 134 PCTLEQAIQLAGLAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLH 192
C E ++ LA LA+QA++GD+ + + + P + ++ L +++ LH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPAR-VMEKLDLSYIKEELPKLH 751
Query: 193 QKYRGLTAPDAEMLYMQEVERMDGYG---EESYPAKDSQGSDISIGACLEGIFV-KHKNG 248
Y G + + E+ +++ +R+ YG +P K SQ + I +G C +G+ V + NG
Sbjct: 752 NTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQ-TGILLGVCSKGVLVFEVHNG 810
Query: 249 RHPVVFR--WHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKF--- 303
+V R W + +S +K L+ + FQT++ + +Y+ LC +HKF
Sbjct: 811 VRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQ 870
Query: 304 YRLNQCNLQTQTV 316
R Q N Q +
Sbjct: 871 MRARQSNQDAQDI 883
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 173 bits (438), Expect = 1e-42
Identities = 98/287 (34%), Positives = 156/287 (54%), Gaps = 23/287 (8%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
++L L+QG+ E E + + + +D +C + EN +NR++++LPYD RV L
Sbjct: 2011 RVLRGLLDQGIPSKELENLQELKPLD-QCLIGQTKENRRKNRYKNILPYDATRVPL---- 2065
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ GYINAS IK+ V E+ YIA QGPL T DFWQM+WEQ +IAM+T E EG +
Sbjct: 2066 GDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEK 2125
Query: 1005 EKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTD 1064
K RYWP + + T+ R ++ + + ++ + T + R + HL +T
Sbjct: 2126 IKCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2184
Query: 1065 WPEHGC---PEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILS 1121
WP+H P+DL F+SY+ I + P++ HCSAG+GR+G +I
Sbjct: 2185 WPDHDTPSQPDDLLTFISYMRHIHR--------------SGPIITHCSAGIGRSGTLICI 2230
Query: 1122 EIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL 1168
++++ + + DI ++ +R QR +VQT QY F Y+V++ L
Sbjct: 2231 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2277
Score = 113 bits (283), Expect = 9e-25
Identities = 89/315 (28%), Positives = 154/315 (48%), Gaps = 28/315 (8%)
Query: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVD------- 79
I LLN + +E T ++ ++ + V + L E F+L K N+ +VD
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATL-KDNEYFFVDPDLKLTK 634
Query: 80 ------LEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSI 133
E+P KK K + T++F + F++ VS +Q +T +QYYLQL+KDILE +
Sbjct: 635 VAPEGWKEEPKKKT--KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 134 PCTLEQAIQLAGLAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLH 192
C E ++ LA LA+QA++GD+ + + + P + ++ L +++ LH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPAR-VMEKLDLSYIKEELPKLH 751
Query: 193 QKYRGLTAPDAEMLYMQEVERMDGYG---EESYPAKDSQGSDISIGACLEGIFV-KHKNG 248
Y G + + E+ +++ +R+ YG +P K SQ + I +G C +G+ V + NG
Sbjct: 752 NTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQ-TGILLGVCSKGVLVFEVHNG 810
Query: 249 RHPVVFR--WHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKF--- 303
+V R W + +S +K L+ + FQT++ + +Y+ LC +HKF
Sbjct: 811 VRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQ 870
Query: 304 YRLNQCNLQTQTVTV 318
R Q N Q + V
Sbjct: 871 MRARQSNQDAQDIDV 885
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 173 bits (438), Expect = 1e-42
Identities = 98/287 (34%), Positives = 156/287 (54%), Gaps = 23/287 (8%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
++L L+QG+ E E + + + +D +C + EN +NR++++LPYD RV L
Sbjct: 2202 RVLRGLLDQGIPSKELENLQELKPLD-QCLIGQTKENRRKNRYKNILPYDATRVPL---- 2256
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ GYINAS IK+ V E+ YIA QGPL T DFWQM+WEQ +IAM+T E EG +
Sbjct: 2257 GDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEK 2316
Query: 1005 EKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTD 1064
K RYWP + + T+ R ++ + + ++ + T + R + HL +T
Sbjct: 2317 IKCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2375
Query: 1065 WPEHGC---PEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILS 1121
WP+H P+DL F+SY+ I + P++ HCSAG+GR+G +I
Sbjct: 2376 WPDHDTPSQPDDLLTFISYMRHIHR--------------SGPIITHCSAGIGRSGTLICI 2421
Query: 1122 EIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL 1168
++++ + + DI ++ +R QR +VQT QY F Y+V++ L
Sbjct: 2422 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2468
Score = 112 bits (280), Expect = 2e-24
Identities = 88/313 (28%), Positives = 153/313 (48%), Gaps = 28/313 (8%)
Query: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVD------- 79
I LLN + +E T ++ ++ + V + L E F+L K N+ +VD
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATL-KDNEYFFVDPDLKLTK 634
Query: 80 ------LEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSI 133
E+P KK K + T++F + F++ VS +Q +T +QYYLQL+KDILE +
Sbjct: 635 VAPEGWKEEPKKKT--KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 134 PCTLEQAIQLAGLAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLH 192
C E ++ LA LA+QA++GD+ + + + P + ++ L +++ LH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPAR-VMEKLDLSYIKEELPKLH 751
Query: 193 QKYRGLTAPDAEMLYMQEVERMDGYG---EESYPAKDSQGSDISIGACLEGIFV-KHKNG 248
Y G + + E+ +++ +R+ YG +P K SQ + I +G C +G+ V + NG
Sbjct: 752 NTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQ-TGILLGVCSKGVLVFEVHNG 810
Query: 249 RHPVVFR--WHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKF--- 303
+V R W + +S +K L+ + FQT++ + +Y+ LC +HKF
Sbjct: 811 VRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQ 870
Query: 304 YRLNQCNLQTQTV 316
R Q N Q +
Sbjct: 871 MRARQSNQDAQDI 883
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 173 bits (438), Expect = 1e-42
Identities = 98/287 (34%), Positives = 156/287 (54%), Gaps = 23/287 (8%)
Query: 885 KILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944
++L L+QG+ E E + + + +D +C + EN +NR++++LPYD RV L
Sbjct: 2183 RVLRGLLDQGIPSKELENLQELKPLD-QCLIGQTKENRRKNRYKNILPYDATRVPL---- 2237
Query: 945 ENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR 1004
+ GYINAS IK+ V E+ YIA QGPL T DFWQM+WEQ +IAM+T E EG +
Sbjct: 2238 GDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEK 2297
Query: 1005 EKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTD 1064
K RYWP + + T+ R ++ + + ++ + T + R + HL +T
Sbjct: 2298 IKCQRYWPNILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2356
Query: 1065 WPEHGC---PEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILS 1121
WP+H P+DL F+SY+ I + P++ HCSAG+GR+G +I
Sbjct: 2357 WPDHDTPSQPDDLLTFISYMRHIHR--------------SGPIITHCSAGIGRSGTLICI 2402
Query: 1122 EIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL 1168
++++ + + DI ++ +R QR +VQT QY F Y+V++ L
Sbjct: 2403 DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2449
Score = 112 bits (280), Expect = 2e-24
Identities = 88/313 (28%), Positives = 153/313 (48%), Gaps = 28/313 (8%)
Query: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVD------- 79
I LLN + +E T ++ ++ + V + L E F+L K N+ +VD
Sbjct: 576 IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATL-KDNEYFFVDPDLKLTK 634
Query: 80 ------LEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSI 133
E+P KK K + T++F + F++ VS +Q +T +QYYLQL+KDILE +
Sbjct: 635 VAPEGWKEEPKKKT--KATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 134 PCTLEQAIQLAGLAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLH 192
C E ++ LA LA+QA++GD+ + + + P + ++ L +++ LH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPAR-VMEKLDLSYIKEELPKLH 751
Query: 193 QKYRGLTAPDAEMLYMQEVERMDGYG---EESYPAKDSQGSDISIGACLEGIFV-KHKNG 248
Y G + + E+ +++ +R+ YG +P K SQ + I +G C +G+ V + NG
Sbjct: 752 NTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQ-TGILLGVCSKGVLVFEVHNG 810
Query: 249 RHPVVFR--WHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKF--- 303
+V R W + +S +K L+ + FQT++ + +Y+ LC +HKF
Sbjct: 811 VRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQ 870
Query: 304 YRLNQCNLQTQTV 316
R Q N Q +
Sbjct: 871 MRARQSNQDAQDI 883
>gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Homo
sapiens]
Length = 593
Score = 172 bits (436), Expect = 2e-42
Identities = 103/303 (33%), Positives = 159/303 (52%), Gaps = 15/303 (4%)
Query: 879 TNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRV 938
T E + R +QG ++ EYE I ++ V G + P N E+NR+ DV D RV
Sbjct: 287 TIQELVDYVNARQKQG-IYEEYEDIRRENPV-GTFHCSMSPGNLEKNRYGDVPCLDQTRV 344
Query: 939 ELVPTK-ENNTGYINASHIKVSVSGIEWD--YIATQGPLQNTCQDFWQMVWEQGIAIIAM 995
+L T YINAS + G + YI TQGPL+NT +DFW MVWEQ + +I M
Sbjct: 345 KLTKRSGHTQTDYINASFM----DGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVM 400
Query: 996 VTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQER 1055
T EEGGR K +YWP + + + +G +T + Y T L++ + Q+R
Sbjct: 401 TTRFEEGGRRKCGQYWPL--EKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKR 458
Query: 1056 TVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVR----RHTNSTSDPQSPNPPLLVHCSAG 1111
V H Q+ WP++G P + +L +++ + + + S Q P PP++VHCSAG
Sbjct: 459 QVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAG 518
Query: 1112 VGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS 1171
+GRTG +I +A LE L++ + + +R QR +QT QY F Y+ +++F +
Sbjct: 519 IGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE 578
Query: 1172 RLI 1174
++
Sbjct: 579 GMV 581
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 171 bits (433), Expect = 4e-42
Identities = 99/273 (36%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1237 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1296
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1297 GYRQ--QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA---- 1350
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1351 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1410
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1411 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1463
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT QY F YR +++L S
Sbjct: 1464 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 144 bits (364), Expect = 4e-34
Identities = 89/253 (35%), Positives = 136/253 (53%), Gaps = 18/253 (7%)
Query: 916 ARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWDYIATQGP 973
+ L N +NR+ +V+ YD RV L+ E G Y+NA++I + YIATQG
Sbjct: 965 SNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPGSDYVNANYIDGYRK--QNAYIATQGS 1021
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L T DFW+M+WEQ A + M+T EE R K +YWP G T T+G ++T
Sbjct: 1022 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDT 1077
Query: 1034 TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS 1093
+ Y + + ++R V Q+T WP+HG PE FL++L ++
Sbjct: 1078 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK-------- 1129
Query: 1094 TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQT 1153
T +P P ++VHCSAGVGRTG I+ + M+ ++H + +DI + ++R QR +VQT
Sbjct: 1130 TCNPPDAGP-MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1188
Query: 1154 LCQYTFVYRVLIQ 1166
QY F++ L++
Sbjct: 1189 EDQYIFIHDALLE 1201
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 171 bits (433), Expect = 4e-42
Identities = 99/273 (36%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1647 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1706
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1707 GYRQ--QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA---- 1760
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1761 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1820
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1821 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1873
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT QY F YR +++L S
Sbjct: 1874 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 144 bits (364), Expect = 4e-34
Identities = 89/253 (35%), Positives = 136/253 (53%), Gaps = 18/253 (7%)
Query: 916 ARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWDYIATQGP 973
+ L N +NR+ +V+ YD RV L+ E G Y+NA++I + YIATQG
Sbjct: 1375 SNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPGSDYVNANYIDGYRK--QNAYIATQGS 1431
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L T DFW+M+WEQ A + M+T EE R K +YWP G T T+G ++T
Sbjct: 1432 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDT 1487
Query: 1034 TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS 1093
+ Y + + ++R V Q+T WP+HG PE FL++L ++
Sbjct: 1488 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK-------- 1539
Query: 1094 TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQT 1153
T +P P ++VHCSAGVGRTG I+ + M+ ++H + +DI + ++R QR +VQT
Sbjct: 1540 TCNPPDAGP-MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1598
Query: 1154 LCQYTFVYRVLIQ 1166
QY F++ L++
Sbjct: 1599 EDQYIFIHDALLE 1611
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 171 bits (433), Expect = 4e-42
Identities = 99/273 (36%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1634 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1693
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1694 GYRQ--QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA---- 1747
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1748 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1807
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1808 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1860
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT QY F YR +++L S
Sbjct: 1861 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 144 bits (364), Expect = 4e-34
Identities = 89/253 (35%), Positives = 136/253 (53%), Gaps = 18/253 (7%)
Query: 916 ARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWDYIATQGP 973
+ L N +NR+ +V+ YD RV L+ E G Y+NA++I + YIATQG
Sbjct: 1362 SNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPGSDYVNANYIDGYRK--QNAYIATQGS 1418
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L T DFW+M+WEQ A + M+T EE R K +YWP G T T+G ++T
Sbjct: 1419 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDT 1474
Query: 1034 TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS 1093
+ Y + + ++R V Q+T WP+HG PE FL++L ++
Sbjct: 1475 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK-------- 1526
Query: 1094 TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQT 1153
T +P P ++VHCSAGVGRTG I+ + M+ ++H + +DI + ++R QR +VQT
Sbjct: 1527 TCNPPDAGP-MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1585
Query: 1154 LCQYTFVYRVLIQ 1166
QY F++ L++
Sbjct: 1586 EDQYIFIHDALLE 1598
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 171 bits (433), Expect = 4e-42
Identities = 99/273 (36%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1638 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1697
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1698 GYRQ--QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA---- 1751
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1752 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1811
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1812 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1864
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT QY F YR +++L S
Sbjct: 1865 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 144 bits (364), Expect = 4e-34
Identities = 89/253 (35%), Positives = 136/253 (53%), Gaps = 18/253 (7%)
Query: 916 ARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWDYIATQGP 973
+ L N +NR+ +V+ YD RV L+ E G Y+NA++I + YIATQG
Sbjct: 1366 SNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPGSDYVNANYIDGYRK--QNAYIATQGS 1422
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L T DFW+M+WEQ A + M+T EE R K +YWP G T T+G ++T
Sbjct: 1423 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDT 1478
Query: 1034 TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS 1093
+ Y + + ++R V Q+T WP+HG PE FL++L ++
Sbjct: 1479 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK-------- 1530
Query: 1094 TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQT 1153
T +P P ++VHCSAGVGRTG I+ + M+ ++H + +DI + ++R QR +VQT
Sbjct: 1531 TCNPPDAGP-MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
Query: 1154 LCQYTFVYRVLIQ 1166
QY F++ L++
Sbjct: 1590 EDQYIFIHDALLE 1602
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 171 bits (433), Expect = 4e-42
Identities = 99/273 (36%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1236 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1295
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1296 GYRQ--QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA---- 1349
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1350 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1409
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1410 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1462
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT QY F YR +++L S
Sbjct: 1463 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 144 bits (364), Expect = 4e-34
Identities = 89/253 (35%), Positives = 136/253 (53%), Gaps = 18/253 (7%)
Query: 916 ARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHIKVSVSGIEWDYIATQGP 973
+ L N +NR+ +V+ YD RV L+ E G Y+NA++I + YIATQG
Sbjct: 964 SNLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPGSDYVNANYIDGYRK--QNAYIATQGS 1020
Query: 974 LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFR 1033
L T DFW+M+WEQ A + M+T EE R K +YWP G T T+G ++T
Sbjct: 1021 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDT 1076
Query: 1034 TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS 1093
+ Y + + ++R V Q+T WP+HG PE FL++L ++
Sbjct: 1077 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK-------- 1128
Query: 1094 TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQT 1153
T +P P ++VHCSAGVGRTG I+ + M+ ++H + +DI + ++R QR +VQT
Sbjct: 1129 TCNPPDAGP-MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1187
Query: 1154 LCQYTFVYRVLIQ 1166
QY F++ L++
Sbjct: 1188 EDQYIFIHDALLE 1200
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 169 bits (427), Expect = 2e-41
Identities = 97/273 (35%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1240 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1299
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1300 GYRQ--QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA---- 1353
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1354 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1413
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1414 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1466
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT +Y F Y+ +++L S
Sbjct: 1467 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1499
Score = 153 bits (386), Expect = 1e-36
Identities = 108/309 (34%), Positives = 159/309 (51%), Gaps = 33/309 (10%)
Query: 862 LSRVPLPDEGKEVATRATNDERCKILEQ-RLEQGMVFTEYERILKKRLVDGECSTARLPE 920
LS P+P +A A + ER K + +L Q EYE I + E S L
Sbjct: 925 LSHPPIP-----IADMAEHTERLKANDSLKLSQ-----EYESIDPGQQFTWEHSN--LEV 972
Query: 921 NAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSGIEWD--YIATQGPLQNT 977
N +NR+ +V+ YD RV L P + + YINA++ V G YIATQGPL T
Sbjct: 973 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANY----VDGYRCQNAYIATQGPLPET 1028
Query: 978 CQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSG 1037
DFW+MVWEQ A I M+T EE R K +YWP G T TYG ++T +
Sbjct: 1029 FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELA 1084
Query: 1038 CYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDP 1097
+ + + ++R V Q+T WP+HG PE FL++L ++ T +P
Sbjct: 1085 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVK--------TCNP 1136
Query: 1098 QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQY 1157
P++VHCSAGVGRTG I+ + M+ ++ + +D+ + ++R QR +VQT QY
Sbjct: 1137 PDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1195
Query: 1158 TFVYRVLIQ 1166
+F++ L++
Sbjct: 1196 SFIHEALLE 1204
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 169 bits (427), Expect = 2e-41
Identities = 97/273 (35%), Positives = 145/273 (53%), Gaps = 14/273 (5%)
Query: 899 EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIK 957
E++R+ + +A LP N +NR +++PY+ RV L P + + YINAS I
Sbjct: 1645 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1704
Query: 958 VSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSR 1017
+ YIATQGPL T +DFW+M+WE I+ M+T E GREK +YWP
Sbjct: 1705 GYRQ--QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA---- 1758
Query: 1018 HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGF 1077
+ Y F + + Y K+ GQ RTV Q+TDWPE G P+ +GF
Sbjct: 1759 ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGF 1818
Query: 1078 LSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIP 1137
+ ++ ++ + T + + P+ VHCSAGVGRTGV I I++ + + V+DI
Sbjct: 1819 IDFIGQV-------HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1871
Query: 1138 RVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS 1170
+ + MLR QR +VQT +Y F Y+ +++L S
Sbjct: 1872 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Score = 153 bits (386), Expect = 1e-36
Identities = 108/309 (34%), Positives = 159/309 (51%), Gaps = 33/309 (10%)
Query: 862 LSRVPLPDEGKEVATRATNDERCKILEQ-RLEQGMVFTEYERILKKRLVDGECSTARLPE 920
LS P+P +A A + ER K + +L Q EYE I + E S L
Sbjct: 1330 LSHPPIP-----IADMAEHTERLKANDSLKLSQ-----EYESIDPGQQFTWEHSN--LEV 1377
Query: 921 NAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSGIEWD--YIATQGPLQNT 977
N +NR+ +V+ YD RV L P + + YINA++ V G YIATQGPL T
Sbjct: 1378 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANY----VDGYRCQNAYIATQGPLPET 1433
Query: 978 CQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSG 1037
DFW+MVWEQ A I M+T EE R K +YWP G T TYG ++T +
Sbjct: 1434 FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELA 1489
Query: 1038 CYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDP 1097
+ + + ++R V Q+T WP+HG PE FL++L ++ T +P
Sbjct: 1490 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVK--------TCNP 1541
Query: 1098 QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQY 1157
P++VHCSAGVGRTG I+ + M+ ++ + +D+ + ++R QR +VQT QY
Sbjct: 1542 PDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1600
Query: 1158 TFVYRVLIQ 1166
+F++ L++
Sbjct: 1601 SFIHEALLE 1609
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,576,491
Number of Sequences: 37866
Number of extensions: 2629322
Number of successful extensions: 18455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 244
Number of HSP's that attempted gapping in prelim test: 16257
Number of HSP's gapped (non-prelim): 1627
length of query: 1174
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1061
effective length of database: 13,968,660
effective search space: 14820748260
effective search space used: 14820748260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.