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Search of human proteins with 149158709
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149158709 histamine receptor H1 [Homo sapiens]
(487 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149158709 histamine receptor H1 [Homo sapiens] 996 0.0
gi|149158706 histamine receptor H1 [Homo sapiens] 996 0.0
gi|149158704 histamine receptor H1 [Homo sapiens] 996 0.0
gi|4504491 histamine receptor H1 [Homo sapiens] 996 0.0
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 194 1e-49
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 185 7e-47
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 185 9e-47
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 182 5e-46
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 155 1e-37
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 149 6e-36
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 148 1e-35
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 138 1e-32
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 126 5e-29
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 122 7e-28
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 121 1e-27
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 121 1e-27
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 119 8e-27
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 118 1e-26
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 118 1e-26
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 114 3e-25
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 113 4e-25
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 113 4e-25
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 996 bits (2574), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
Query: 481 RILHIRS 487
RILHIRS
Sbjct: 481 RILHIRS 487
>gi|149158706 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 996 bits (2574), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
Query: 481 RILHIRS 487
RILHIRS
Sbjct: 481 RILHIRS 487
>gi|149158704 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 996 bits (2574), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
Query: 481 RILHIRS 487
RILHIRS
Sbjct: 481 RILHIRS 487
>gi|4504491 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 996 bits (2574), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
Query: 481 RILHIRS 487
RILHIRS
Sbjct: 481 RILHIRS 487
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 194 bits (494), Expect = 1e-49
Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)
Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
+++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M +
Sbjct: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88
Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148
Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
I AW +SF LW IL W + + + +V D+C+ F TAI FY+P
Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207
Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253
+M Y +IY+ + + + S K +P + P+ A++
Sbjct: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
Query: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311
++ W +R G S PS K + S + DK P L +V+
Sbjct: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
Query: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363
E ++ A +K + + L + A+ + Q + +
Sbjct: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
Query: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413
D ET G K+ + S GL+ SH + + +ERKA
Sbjct: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440
Query: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473
A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN
Sbjct: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500
Query: 474 NFKKTFKRILHIR 486
F+KTFK +L R
Sbjct: 501 TFRKTFKMLLLCR 513
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 189 bits (480), Expect = 5e-48
Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)
Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD
Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL
Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
Y RT A I AW LSF LW IL W + +V + +C F+
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
+ P G + + Q K + PV + E ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
+ + +S VA N ++ DE ++T H E S+ + ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
+ S G + +++ ++Q +RE+K + + I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 185 bits (470), Expect = 7e-47
Identities = 138/469 (29%), Positives = 211/469 (44%), Gaps = 42/469 (8%)
Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
+++ + V ++ LVTV N+LV+ +++ R+L TV N ++ SL+ ADLI+GA M +
Sbjct: 31 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYT 90
Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
+Y++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Y RT A
Sbjct: 91 VYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 150
Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
I AW LSF LW IL W + + +V +++C F TAI FYLP +
Sbjct: 151 LMIAAAWVLSFVLWAPAILFWQFVVGKRTV-PDNQCFIQFLSNPAVTFGTAIAAFYLPVV 209
Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKP 264
+M Y I A R K RPE PK K ++K+
Sbjct: 210 IMTVLYIHISLASRSRVH---------------KHRPEGPKEKKAKTLAFLKSPLMKQSV 254
Query: 265 KDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAV 324
K G + + K ++P R V D ++ GS+
Sbjct: 255 KKPPPGEAAREELRNGKLEEAPPPALPPPPRPV-------ADKDTSNESSSGSATQNTK- 306
Query: 325 NRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR---------TDSDTTTETAPG-KG 374
R +L T E A + + + L + +S+ + T E P
Sbjct: 307 ERPATELSTTEATTPAMPAPPL-QPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPA 365
Query: 375 KLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIF 434
+R +N + ++R RQ + RERK + + I+ AFIL W PY +
Sbjct: 366 GMRPAANVARKFASIARNQVRK-KRQMAA-----RERKVTRTIFAILLAFILTWTPYNVM 419
Query: 435 FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
+V FC++C + + WL Y+NST+NP Y LCN FKKTF+ +L
Sbjct: 420 VLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 185 bits (469), Expect = 9e-47
Identities = 140/464 (30%), Positives = 212/464 (45%), Gaps = 66/464 (14%)
Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
+ + L TV NLLVL + + +L TV N +++SL+ ADLI+G M + YLLM
Sbjct: 30 ITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMG 89
Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
W+LG C WL++DYVAS AS+ ++ ++ DRY SV +PL Y RT RA+ I A
Sbjct: 90 HWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLA 149
Query: 152 WFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
W +SF LW IL W + + + +V +C F TA+ FYLP +M Y
Sbjct: 150 WLVSFVLWAPAILFWQYLVGERTV-LAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLY 208
Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
+IY+ + + S + PGK + + G
Sbjct: 209 WRIYRETENRARELAALQGS------------------ETPGKGGGSSSSSERSQPGAEG 250
Query: 271 SVLKSPSQTPKEMKSP---VVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRS 327
S P + + ++P +S +++ E D EGS ++ S
Sbjct: 251 SPETPPGRCCRCCRAPRLLQAYSWKEEEEED----------------EGSME---SLTSS 291
Query: 328 HGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRT-----DSDTTTETAPGKGKLRSGSNT 382
G +E G SE+ + D ++ + T S T + KG+ R+G
Sbjct: 292 EG----EEPG------SEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQ 341
Query: 383 GLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCK 442
K K + + + + +E+KAA+ L I+ AFIL W PY I +V FCK
Sbjct: 342 -----KPRGKEQLAKRKTF----SLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK 392
Query: 443 NCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
+C E L WL Y+NST+NP+ Y LCN+ F+ TF+ +L R
Sbjct: 393 DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCR 436
>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
Length = 590
Score = 182 bits (463), Expect = 5e-46
Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)
Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M +
Sbjct: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
I AW +SF LW IL W +F+ + +V +C F TAI FY+P
Sbjct: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245
Query: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
+M Y +IYK + + + S S S +L+ ++ K +
Sbjct: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305
Query: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
+K G+ W+ + S + + +++ +ED E +Y
Sbjct: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365
Query: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
L + + + + Q+ +E G+ A ++ + + D SF
Sbjct: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421
Query: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
S D+ T++ GK S + L + + T KR +R ++
Sbjct: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479
Query: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
+ + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+
Sbjct: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
Query: 464 NPLIYPLCNENFKKTFKRIL 483
NP+ Y LCN+ F+ TFK +L
Sbjct: 540 NPVCYALCNKTFRTTFKMLL 559
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 155 bits (391), Expect = 1e-37
Identities = 128/460 (27%), Positives = 207/460 (45%), Gaps = 61/460 (13%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
L V+ + + TV N+LV+ AV + R L NL++VSL+ AD++V +VMP ++ L
Sbjct: 54 LAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANEL 113
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
M+ W G+ C +L++D + T+SI + + +DRY SV Q + Y RT R ATI+
Sbjct: 114 MAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIV 173
Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
W +S + P L +Q +C + D TW+ + + I +F+ P L+M
Sbjct: 174 AVWLISAVISFPPL--VSLYRQPDGAAYPQCGLN--DETWYILSSCIGSFFAPCLIMGLV 229
Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269
YA+IY+ + L R+L K P P D P E+ A
Sbjct: 230 YARIYRVAK-------LRTRTLSE----KRAPVGP--DGASPTTEN--------GLGAAA 268
Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329
G+ P P D+ +++A R R G
Sbjct: 269 GAGENGHCAPP-----------------------PADVEPDESSAAAERRRRRGALRRGG 305
Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGK-GKLRSGSNTGLDYIK 388
+ + +G GA ++ Q G + S T +PG G+L S+ +++
Sbjct: 306 RRRAGAEG----GAGG-ADGQGAGPGAAES---GALTASRSPGPGGRLSRASSRSVEF-- 355
Query: 389 FTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCN-- 446
F +R R+ S + RE++ L +M F+LCW P+F + + C+ C
Sbjct: 356 FLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVP 415
Query: 447 EHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
L F W+GY NS+LNP+IY + N++F+++FK IL R
Sbjct: 416 GPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRR 455
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 149 bits (376), Expect = 6e-36
Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%)
Query: 33 VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92
+L+ + V V N+LV AV E+ L T N IVSL+VADL+V +VMP + ++ +
Sbjct: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
Query: 93 WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151
W R C ++++D + TASI ++ + IDRY +V P+ Y +Y +K R + I
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
Query: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
W LSF P+L G N+ Q + F V ++I++FY+P ++ L Y
Sbjct: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209
Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
KIY +R+ + R RS +F P KG+ P V
Sbjct: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255
Query: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330
++KS P + + + E++ L + + Y + SH Q
Sbjct: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304
Query: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387
L + GL++ S ++ + G ++ + +T P GK R+
Sbjct: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354
Query: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447
L++ SR+ +S +E+KA + L ++ FI+CW+P+FI ++ C
Sbjct: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405
Query: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484
L+ WLGY+NS +NP+IY N F+K F +ILH
Sbjct: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 148 bits (373), Expect = 1e-35
Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 63/475 (13%)
Query: 17 GNKTTMASPQL-MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLI 75
G + T S Q+ + LV + + L+TV N+LV+ AV + R L NL++VSL+ AD++
Sbjct: 37 GARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL 96
Query: 76 VGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY 135
V +V+P ++ +M W G+ C +L++D + T+SI + + +DRY S+ Q + Y
Sbjct: 97 VATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156
Query: 136 LKYRTKTRASATILGAWFLSFLWVIPIL------GWNHFMQQTSVRREDKCETDFYDVTW 189
RT R A I+ W +S + P L G Q E +CE + D W
Sbjct: 157 NLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA----EPRCEIN--DQKW 210
Query: 190 FKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAK 249
+ + + I +F+ P L+M+ Y +IY+ ++ R PS P G +
Sbjct: 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRR-------TRVPPSRRGPDAVAAPPGGTER 263
Query: 250 KPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVH 309
+P P + GG P+Q P D +D
Sbjct: 264 RPNGLGP-----ERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALD----------- 307
Query: 310 MQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTET 369
E SS D+ R G + E+G G + S+ + GDS +
Sbjct: 308 ---LEESSSSDH--AERPPGP-RRPERGPRGKGKARASQVKP-GDSLPRRGPGATGIGTP 360
Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWI 429
A G G+ R G+ K R RQ NRE++ L ++ F++CW
Sbjct: 361 AAGPGEERVGAA----------KASRWRGRQ-------NREKRFTFVLAVVIGVFVVCWF 403
Query: 430 PYFIFFMVIAF-CKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
P+F + + A C L F W GY NS+LNP+IY + N +F++ FK+IL
Sbjct: 404 PFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 138 bits (348), Expect = 1e-32
Identities = 115/478 (24%), Positives = 206/478 (43%), Gaps = 75/478 (15%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
+ ++ + L T+ N LV+ AV + R L NL++VSL+ AD++V +++P ++ L
Sbjct: 15 IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
+ W R C +L++D + T+SI + + +DRY +V + L Y RT R IL
Sbjct: 75 LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134
Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
W ++ + +P L + Q R +C+ + W+ + ++I +F+ P L+M+
Sbjct: 135 TVWLIAAVISLPPLIYKG-DQGPQPRGRPQCKLN--QEAWYILASSIGSFFAPCLIMILV 191
Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269
Y +IY ++ N +G K G P + ++P+ G
Sbjct: 192 YLRIYLIAKR----------------------SNRRGPRAKGG---PGQGESKQPRPDHG 226
Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329
G++ + K P + S REV+ + + + +R A+ S
Sbjct: 227 GALASA--------KLPALASVASAREVNGHSKSTGEKEEGETPEDTGTR---ALPPSWA 275
Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPG----------------- 372
L QG G S + + + + + + P
Sbjct: 276 ALPNSGQG-QKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR 334
Query: 373 -----KGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILC 427
+G++ G G I W R R+ + RE++ L ++ F+LC
Sbjct: 335 VLATLRGQVLLGRGVGA--IGGQWWRRRA---------QLTREKRFTFVLAVVIGVFVLC 383
Query: 428 WIPYFIFFMVIAFC-KNCCNEH-LHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
W P+F + + A C K+C H L F W+GY NS+LNP+IY + N++F++ F+RIL
Sbjct: 384 WFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 126 bits (316), Expect = 5e-29
Identities = 80/241 (33%), Positives = 123/241 (51%), Gaps = 13/241 (5%)
Query: 6 SSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLY 65
++C E M KT + +VV++T+ T LNL V+ A+ + +KLH N
Sbjct: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTL---TTLLNLAVIMAIGTTKKLHQPANYL 60
Query: 66 IVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDR 125
I SL+V DL+V +VMP++I+Y++M +W LG LC WLS+D T SI + ++ +DR
Sbjct: 61 ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR 120
Query: 126 YRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFY 185
Y ++ + Y + RT RA+ IL W +S +P L W + + + + D
Sbjct: 121 YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV 180
Query: 186 DVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQ----HRELINRSLP---SFSEIK 238
T + + A FY+P L+L Y +IY A + Q R L NRS SF+ K
Sbjct: 181 IYTIYSTLGA---FYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCK 237
Query: 239 L 239
L
Sbjct: 238 L 238
Score = 79.7 bits (195), Expect = 5e-15
Identities = 38/88 (43%), Positives = 55/88 (62%), Gaps = 3/88 (3%)
Query: 399 RQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGY 458
RQ +S RERKAA+ LG I+ AFIL W+P+FI +++ + + F WLGY
Sbjct: 278 RQQISS---TRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGY 334
Query: 459 INSTLNPLIYPLCNENFKKTFKRILHIR 486
+NS +NPL+Y NE+FK FK+++ R
Sbjct: 335 VNSLINPLLYTSFNEDFKLAFKKLIRCR 362
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 122 bits (306), Expect = 7e-28
Identities = 75/243 (30%), Positives = 124/243 (51%), Gaps = 8/243 (3%)
Query: 2 SLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTV 61
S P+ +C +D + + + ++ P + LV++L+ I L T N V+ V RKLHT
Sbjct: 27 SAPSQNCSAKDYIYQDS---ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP 83
Query: 62 GNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFIL 121
N I SL+V DL+V +VMP++ +Y + +W+LG+ +C FWLS D TASI + ++
Sbjct: 84 ANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVI 143
Query: 122 CIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCE 181
+DRY ++ + Y RT RA+ I W S +P W + V +C
Sbjct: 144 ALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEV---SECV 200
Query: 182 TDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRP 241
+ D + V + + FY PTLL++ Y +IY R ++ NR+ + +L
Sbjct: 201 VN-TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL-KQTPNRTGKRLTRAQLIT 258
Query: 242 ENP 244
++P
Sbjct: 259 DSP 261
Score = 92.8 bits (229), Expect = 6e-19
Identities = 39/80 (48%), Positives = 57/80 (71%), Gaps = 2/80 (2%)
Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTI--WLGYINSTLNPL 466
RERKA K LG I+ AFI+CW+P+FI +V+ CK+ C HL +F WLGY+NS +NP+
Sbjct: 308 RERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPI 367
Query: 467 IYPLCNENFKKTFKRILHIR 486
IY + NE+FK+ F +++ +
Sbjct: 368 IYTMSNEDFKQAFHKLIRFK 387
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 121 bits (304), Expect = 1e-27
Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
+ VVL+ + L+TV N++V AV R+L + N +IVSL++ DL++G +V+P + +Y L
Sbjct: 21 ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
KWS G+ C + S+D + TASI ++F++ +DRY +V PLRY T R + +++
Sbjct: 81 SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140
Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203
W LSFL + LGWN +TS KC+ +V + ++ ++ FYLP
Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195
Query: 204 LLMLWFYAKIYKAVRQHCQ 222
L+M Y +I+K R +
Sbjct: 196 LIMCITYYRIFKVARDQAK 214
Score = 66.6 bits (161), Expect = 5e-11
Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467
RE KA L +M AFI+CW PYF F+ + NE L +WLGY NS LNP++
Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287
Query: 468 YPLCNENFKKTFKRILHIR 486
Y N +F+ ++++ R
Sbjct: 288 YAALNRDFRTGYQQLFCCR 306
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 121 bits (304), Expect = 1e-27
Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
+ VVL+ + L+TV N++V AV R+L + N +IVSL++ DL++G +V+P + +Y L
Sbjct: 21 ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
KWS G+ C + S+D + TASI ++F++ +DRY +V PLRY T R + +++
Sbjct: 81 SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140
Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203
W LSFL + LGWN +TS KC+ +V + ++ ++ FYLP
Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195
Query: 204 LLMLWFYAKIYKAVRQHCQ 222
L+M Y +I+K R +
Sbjct: 196 LIMCITYYRIFKVARDQAK 214
Score = 66.6 bits (161), Expect = 5e-11
Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467
RE KA L +M AFI+CW PYF F+ + NE L +WLGY NS LNP++
Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287
Query: 468 YPLCNENFKKTFKRILHIR 486
Y N +F+ ++++ R
Sbjct: 288 YAALNRDFRTGYQQLFCCR 306
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 119 bits (297), Expect = 8e-27
Identities = 62/195 (31%), Positives = 112/195 (57%), Gaps = 5/195 (2%)
Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
+V+S I L V N+LV+ A+ +L TV N +I SL+ ADL++G V+P ++LM
Sbjct: 38 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97
Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
W+ G C FW S+D + TASI ++ ++ +DRY ++ P +Y TK +A IL
Sbjct: 98 MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 157
Query: 152 WFLSFLW-VIPI-LGWNHFMQQTSVR--REDKCETDFYDVTWFKVMTAIINFYLPTLLML 207
W +S L +PI + W Q ++ + C DF+ + + ++I++FY+P ++M+
Sbjct: 158 WIVSGLTSFLPIQMHWYRATHQEAINCYANETC-CDFFTNQAYAIASSIVSFYVPLVIMV 216
Query: 208 WFYAKIYKAVRQHCQ 222
+ Y+++++ ++ Q
Sbjct: 217 FVYSRVFQEAKRQLQ 231
Score = 66.2 bits (160), Expect = 6e-11
Identities = 31/78 (39%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIY 468
+E KA K LG IM F LCW+P+FI +V N + +++ W+GY+NS NPLIY
Sbjct: 267 KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 326
Query: 469 PLCNENFKKTFKRILHIR 486
+ +F+ F+ +L +R
Sbjct: 327 -CRSPDFRIAFQELLCLR 343
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 118 bits (296), Expect = 1e-26
Identities = 68/189 (35%), Positives = 99/189 (52%), Gaps = 4/189 (2%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
L VVLS I L TV N VL + RKLHT N I SL+ DL+V +VMP++I Y +
Sbjct: 41 LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
W+ G+ LC WLS D TASI + ++ +DRY ++ L Y K RT A+ I
Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
W +S IP L W Q + C + ++ + + + FY+P++L++
Sbjct: 161 IVWAISICISIPPLFWRQAKAQEEM---SDCLVNTSQIS-YTIYSTCGAFYIPSVLLIIL 216
Query: 210 YAKIYKAVR 218
Y +IY+A R
Sbjct: 217 YGRIYRAAR 225
Score = 87.8 bits (216), Expect = 2e-17
Identities = 38/80 (47%), Positives = 56/80 (70%), Gaps = 2/80 (2%)
Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEH--LHMFTIWLGYINSTLNPL 466
RERKA K LG I+ AFI+CW+P+F+ +V+ C++ C H L F WLGY+NS +NP+
Sbjct: 295 RERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPI 354
Query: 467 IYPLCNENFKKTFKRILHIR 486
IY + NE F++ F++I+ R
Sbjct: 355 IYTVFNEEFRQAFQKIVPFR 374
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 118 bits (295), Expect = 1e-26
Identities = 67/194 (34%), Positives = 104/194 (53%), Gaps = 5/194 (2%)
Query: 25 PQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMN 84
P + + + LS + L+T +N LV+ A+ RKLH N I SL+V D +V +VMP +
Sbjct: 21 PSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFS 80
Query: 85 ILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRA 144
I+Y++ W +G+ +C WLS+D T SI + + +DRYR++ + Y + RT A
Sbjct: 81 IVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHA 140
Query: 145 SATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
I W +S +P L W H Q TS R+D+C +D + + FY+P
Sbjct: 141 GIMITIVWIISVFISMPPLFWRH--QGTS--RDDECIIK-HDHIVSTIYSTFGAFYIPLA 195
Query: 205 LMLWFYAKIYKAVR 218
L+L Y KIY+A +
Sbjct: 196 LILILYYKIYRAAK 209
Score = 101 bits (252), Expect = 1e-21
Identities = 58/152 (38%), Positives = 86/152 (56%), Gaps = 11/152 (7%)
Query: 343 ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSH----- 397
AS I+++++ G S S + T+ K S +T D I T + LRS
Sbjct: 217 ASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEK 276
Query: 398 --SRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTI 454
RQ +SG RERKAA LG I+ AF++CW+P+F+ +V+ C C +E + F
Sbjct: 277 SWRRQKISG---TRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA 333
Query: 455 WLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
WLGY+NS +NPLIY + NE+FKK F++++ R
Sbjct: 334 WLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 114 bits (284), Expect = 3e-25
Identities = 65/191 (34%), Positives = 106/191 (55%), Gaps = 12/191 (6%)
Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
++L T+ V N V+ A+ ER L V N I SL+V DL+V +V+PM LY +++
Sbjct: 41 LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN 100
Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
KW+LG+ C ++++D + T+SI + + +DRY ++ P+ Y+ RT RA+A I
Sbjct: 101 KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT 160
Query: 152 WFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVT---WFKVMTAIINFYLPTLLML 207
W + FL I P+LGW ED+ + D ++ + + + FY+P LLML
Sbjct: 161 WLIGFLISIPPMLGWR--------TPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLML 212
Query: 208 WFYAKIYKAVR 218
Y +I++A R
Sbjct: 213 VLYGRIFRAAR 223
Score = 84.3 bits (207), Expect = 2e-16
Identities = 41/100 (41%), Positives = 61/100 (61%), Gaps = 10/100 (10%)
Query: 390 TWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHL 449
+++R + + + + RERK K LG IM FILCW+P+FI +V+ FC++ C
Sbjct: 320 SFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSC---- 375
Query: 450 HMFTI------WLGYINSTLNPLIYPLCNENFKKTFKRIL 483
HM T+ WLGY NS LNP+IY N++F+ FK+I+
Sbjct: 376 HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 113 bits (282), Expect = 4e-25
Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
L V+L + L V N+LV+ +V R LH+V + YIV+L+VADL++ + V+P + ++ +
Sbjct: 29 LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
+ W+ GR C W ++D + TASI + I+ IDRY V PLRY T+ R +L
Sbjct: 89 LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148
Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208
W LS + I P+ GW +Q + E C+ + + + + +A+ +FYLP ++L
Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202
Query: 209 FYAKIYKAVRQ 219
Y ++Y ++
Sbjct: 203 MYCRVYVVAKR 213
Score = 80.5 bits (197), Expect = 3e-15
Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%)
Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463
L +RE+KAAK LG ++ F+LCW+P+F+ + +F + +E + WLGY+NS +
Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 464 NPLIYPLCNENFKKTFKRILHIR 486
NP+IYP ++ FKK F+ +L I+
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 113 bits (282), Expect = 4e-25
Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%)
Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
L V+L + L V N+LV+ +V R LH+V + YIV+L+VADL++ + V+P + ++ +
Sbjct: 29 LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88
Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
+ W+ GR C W ++D + TASI + I+ IDRY V PLRY T+ R +L
Sbjct: 89 LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148
Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208
W LS + I P+ GW +Q + E C+ + + + + +A+ +FYLP ++L
Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202
Query: 209 FYAKIYKAVRQ 219
Y ++Y ++
Sbjct: 203 MYCRVYVVAKR 213
Score = 80.5 bits (197), Expect = 3e-15
Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%)
Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463
L +RE+KAAK LG ++ F+LCW+P+F+ + +F + +E + WLGY+NS +
Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 464 NPLIYPLCNENFKKTFKRILHIR 486
NP+IYP ++ FKK F+ +L I+
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,241,017
Number of Sequences: 37866
Number of extensions: 805950
Number of successful extensions: 4833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 549
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 3151
Number of HSP's gapped (non-prelim): 1423
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.