Search of human proteins with 148612863

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148612863 transient receptor potential cation channel,
subfamily M, member 7 [Homo sapiens]
         (1865 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148612863 transient receptor potential cation channel, subfam...  3779   0.0  
gi|18921093 transient receptor potential cation channel, subfami...  1499   0.0  
gi|154091314 transient receptor potential cation channel, subfam...  1462   0.0  
gi|154091320 transient receptor potential cation channel, subfam...  1369   0.0  
gi|154091318 transient receptor potential cation channel, subfam...  1368   0.0  
gi|154091312 transient receptor potential cation channel, subfam...  1360   0.0  
gi|154091316 transient receptor potential cation channel, subfam...  1359   0.0  
gi|154091308 transient receptor potential cation channel, subfam...  1355   0.0  
gi|154091310 transient receptor potential cation channel, subfam...  1354   0.0  
gi|94538366 transient receptor potential cation channel, subfami...  1169   0.0  
gi|4507689 transient receptor potential cation channel, subfamil...   506   e-142
gi|11225266 transient receptor potential cation channel, subfami...   418   e-116
gi|45935368 transient receptor potential cation channel, subfami...   362   2e-99
gi|55953096 transient receptor potential cation channel, subfami...   348   3e-95
gi|21314671 transient receptor potential cation channel, subfami...   255   3e-67
gi|109689695 transient receptor potential cation channel, subfam...   240   1e-62
gi|209863032 transient receptor potential cation channel, subfam...    84   1e-15
gi|209863030 transient receptor potential cation channel, subfam...    84   1e-15
gi|209863026 transient receptor potential cation channel, subfam...    84   1e-15
gi|7706747 transient receptor potential cation channel, subfamil...    84   1e-15
gi|209863024 transient receptor potential cation channel, subfam...    84   2e-15
gi|6912736 transient receptor potential cation channel, subfamil...    75   6e-13
gi|148596992 heart alpha-kinase [Homo sapiens]                         70   2e-11
gi|209863028 transient receptor potential cation channel, subfam...    68   1e-10
gi|9558749 elongation factor-2 kinase [Homo sapiens]                   63   3e-09
gi|5730102 transient receptor potential cation channel, subfamil...    62   5e-09
gi|9966865 transient receptor potential cation channel, subfamil...    61   1e-08
gi|194733735 transient receptor potential cation channel, subfam...    60   2e-08
gi|4507687 transient receptor potential cation channel, subfamil...    60   2e-08
gi|156151443 alpha-kinase 1 [Homo sapiens]                             54   1e-06

>gi|148612863 transient receptor potential cation channel, subfamily
            M, member 7 [Homo sapiens]
          Length = 1865

 Score = 3779 bits (9801), Expect = 0.0
 Identities = 1865/1865 (100%), Positives = 1865/1865 (100%)

Query: 1    MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM 60
            MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM
Sbjct: 1    MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM 60

Query: 61   KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI 120
            KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI
Sbjct: 61   KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI 120

Query: 121  LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV 180
            LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV
Sbjct: 121  LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV 180

Query: 181  AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN 240
            AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN
Sbjct: 181  AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN 240

Query: 241  LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV 300
            LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV
Sbjct: 241  LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV 300

Query: 301  LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE 360
            LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE
Sbjct: 301  LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE 360

Query: 361  ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV 420
            ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV
Sbjct: 361  ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV 420

Query: 421  DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT 480
            DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT
Sbjct: 421  DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT 480

Query: 481  KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
            KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL
Sbjct: 481  KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 541  GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600
            GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600

Query: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
            KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
            SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780
            CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780

Query: 781  EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP 840
            EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP
Sbjct: 781  EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP 840

Query: 841  ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
            ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK
Sbjct: 841  ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900

Query: 901  VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
            VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA
Sbjct: 901  VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960

Query: 961  GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
            GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA
Sbjct: 961  GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020

Query: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
            ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY
Sbjct: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080

Query: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
            LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS
Sbjct: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140

Query: 1141 LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT 1200
            LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT
Sbjct: 1141 LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT 1200

Query: 1201 FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV 1260
            FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV
Sbjct: 1201 FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV 1260

Query: 1261 HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK 1320
            HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK
Sbjct: 1261 HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK 1320

Query: 1321 DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK 1380
            DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK
Sbjct: 1321 DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK 1380

Query: 1381 NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF 1440
            NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF
Sbjct: 1381 NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF 1440

Query: 1441 VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS 1500
            VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS
Sbjct: 1441 VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS 1500

Query: 1501 RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER 1560
            RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER
Sbjct: 1501 RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER 1560

Query: 1561 NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG 1620
            NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG
Sbjct: 1561 NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG 1620

Query: 1621 GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA 1680
            GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA
Sbjct: 1621 GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA 1680

Query: 1681 AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP 1740
            AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP
Sbjct: 1681 AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP 1740

Query: 1741 TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE 1800
            TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE
Sbjct: 1741 TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE 1800

Query: 1801 DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS 1860
            DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS
Sbjct: 1801 DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS 1860

Query: 1861 VRLML 1865
            VRLML
Sbjct: 1861 VRLML 1865


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score = 1499 bits (3881), Expect = 0.0
 Identities = 760/1254 (60%), Positives = 936/1254 (74%), Gaps = 42/1254 (3%)

Query: 2    SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61
            SQKSWI+    KREC  IIPSSK+PHRC P CQ+CQ L+RC+CGRL+  HA    S  + 
Sbjct: 12   SQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTIS 71

Query: 62   YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
             +  K         E+WSVEKHT +SPTD +G INFQ G H++ AKY+R SYDTK + +L
Sbjct: 72   AAKGKES-------EQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLL 124

Query: 122  QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
             L+LKEW+MELPKLVISVHGG+Q F +  + K++  +GL+KAA TTGAWI+T G+NTGV+
Sbjct: 125  HLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVS 184

Query: 182  KHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNL 241
            KHVGDALK H+S S RKI T+GI PWGVIEN+ DL+G+DVV  YQTL NPLSKL  LN++
Sbjct: 185  KHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSM 244

Query: 242  HSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVL 301
            HSHFIL DDGTVGKYG E++LRR LEK ++ Q+IH R  QGVPVV L+ EGGPNVIL+V 
Sbjct: 245  HSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVW 304

Query: 302  EYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEA 361
            E +++    PVVVCEGTGRAADLLA+ HK   + G L    + +II  I+ TFNF   ++
Sbjct: 305  ETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQS 362

Query: 362  LHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVD 421
             HLFQ LMECM  ++ IT+F   S+E QD+D+AILTALLKGTN SA +QL L +AWDRVD
Sbjct: 363  KHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVD 422

Query: 422  IAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTK 481
            IAK H+ +Y Q W   +LEQAM DALVMDRV FVKLLIE GV++H+FLTIPRLEELYNTK
Sbjct: 423  IAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTK 482

Query: 482  QGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLG 541
            QGPTN +L HLV+DVKQ  L  GY+ITLIDIGLV+EYL+G  YR  YTRK FR +YN+L 
Sbjct: 483  QGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNL- 541

Query: 542  GNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKK 601
                           + +    S GNR +  E   H+ FI+TAQPY+ K  +++    +K
Sbjct: 542  -------------YRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK 588

Query: 602  RTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRS 661
            ++K++ V  DDPE+  F YP N+LL+WA LMKRQ MA F WQHGEE+  KA++AC +YR+
Sbjct: 589  KSKEQNVS-DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRA 647

Query: 662  MAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTC 721
            MA+EAK+S +VDD SEELK YS  FGQLA++LLE++F+Q+E MAM LLTYEL+NWSNSTC
Sbjct: 648  MAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTC 707

Query: 722  LKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAE 781
            LKLAVS  LRPFV+HTCTQMLL+DMWMGRL MRKNSW K+I+SI++PP IL LE+K+KAE
Sbjct: 708  LKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAE 767

Query: 782  MSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNE-MEIQMKSKKLP 840
            MSH+PQSQD  Q     S+ N  +  E   ++ +   R  D    +N+   ++   + LP
Sbjct: 768  MSHVPQSQD-FQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLP 826

Query: 841  ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
             TRK Y FY APIVKFWF T+AYL FLML+T+ VLV+M+  PSVQEW+V  YIFT AIE 
Sbjct: 827  WTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEV 886

Query: 901  VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
            VREI +SE GK  QK+KVW S+Y+N+++T+AI  F  GF LR+G         D     A
Sbjct: 887  VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWG---------DPPFHTA 937

Query: 961  GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
            GRLIYC++IIFW+ RLLDF AVNQ AGPYV MI KM ANMFYIV+IMA+VLLSFGV RKA
Sbjct: 938  GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKA 997

Query: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
            IL P E PSW+LA+DIVF PYWMI+GEVYA EIDVC++       C PG++LTPFLQAVY
Sbjct: 998  ILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ----PSCPPGSFLTPFLQAVY 1053

Query: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
            LFVQYIIMVNLLIAFFNNVYL +++ISN +WKY RY +IM YHEKP LPPPLI+LSH+  
Sbjct: 1054 LFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGL 1113

Query: 1141 L---FCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERI 1197
            L    CC      +++   G KL+L++ED KKLHDFEEQCVE YF+EK +  +   EERI
Sbjct: 1114 LLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERI 1173

Query: 1198 RVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTA 1251
            RVT ERV +M  Q+KE+ ++V++IK SL SLDSQ+GHLQDLSALTVDTLK L+A
Sbjct: 1174 RVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSA 1227



 Score =  457 bits (1175), Expect = e-128
 Identities = 219/295 (74%), Positives = 254/295 (86%), Gaps = 1/295 (0%)

Query: 1541 LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPP-RGEPVTVYRLEESSPNILNNSM 1599
            +++  K   + +++YSA+ERNNLMRLSQ+IPFTPV    GE +TVYRLEESSP  L+ SM
Sbjct: 1696 ISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSM 1755

Query: 1600 SSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWS 1659
            SSWSQ G  A I+ LS+EEM GGLR+A++V  TWSE DILK G ++I+KSFLPEVV TW 
Sbjct: 1756 SSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWH 1815

Query: 1660 SIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAV 1719
             I++E TVLHLCLREIQQQRAAQKL + FNQ+KP++IPY+PRFLEVFL+YCHSA QW  +
Sbjct: 1816 KIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTI 1875

Query: 1720 EECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1779
            E+ MTGEFRKYNNNNGDEI PTNTLEE+MLAFSHWTYEYTRGELLVLDLQGVGENLTDPS
Sbjct: 1876 EKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1935

Query: 1780 VIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKI 1834
            VIK E K+S  MVFGPANLGEDAI+NF AKHHCNSCCRKLKLPDLKRNDY+P++I
Sbjct: 1936 VIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERI 1990


>gi|154091314 transient receptor potential cation channel, subfamily
            M, member 3 isoform k [Homo sapiens]
          Length = 1707

 Score = 1462 bits (3786), Expect = 0.0
 Identities = 737/1296 (56%), Positives = 961/1296 (74%), Gaps = 79/1296 (6%)

Query: 2    SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM- 60
            +QKSWIE    KRECV+IIPS+KDPHRC              CGRL+ QH   T S+++ 
Sbjct: 60   AQKSWIERAFYKRECVHIIPSTKDPHRCC-------------CGRLIGQHVGLTPSISVL 106

Query: 61   --KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPE 118
              + ++ +L  +  Q+ E+WS+ KHT+ SPTDA+G I FQGG HS +A YVR+S+DTKP+
Sbjct: 107  QNEKNESRLSRNDIQS-EKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPD 165

Query: 119  VILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNT 178
            ++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TTGAWI TGGVNT
Sbjct: 166  LLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNT 225

Query: 179  GVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVL 238
            GV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT+ NP+SKL VL
Sbjct: 226  GVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVL 285

Query: 239  NNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVIL 298
            N++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVALI EGGPNVI 
Sbjct: 286  NSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVIS 345

Query: 299  TVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQ 358
             VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++    ++ TI+KTF + +
Sbjct: 346  IVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTR 405

Query: 359  NEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWD 418
             +A HLF  LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA DQL L LAW+
Sbjct: 406  TQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWN 465

Query: 419  RVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELY 478
            RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+FLTI RLEELY
Sbjct: 466  RVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELY 525

Query: 479  NTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYN 538
            NT+ GP+N  L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y+
Sbjct: 526  NTRHGPSN-TLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYH 584

Query: 539  SLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEG 598
            +L G             P+  K+ +  G   D               P R    T     
Sbjct: 585  NLFG-------------PKRPKALKLLGMEDD--------------IPLRRGRKTT---- 613

Query: 599  KKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKI 658
             KKR ++  +D+DDPE   FP+P +EL++WA LMKRQ MA F WQHGEE+MAKALVACK+
Sbjct: 614  -KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKL 672

Query: 659  YRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSN 718
             ++MA+EA ++D+VDD S+EL   S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN
Sbjct: 673  CKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSN 732

Query: 719  STCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKT 778
            +TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS  KVIL IL+PP+IL LE+K 
Sbjct: 733  ATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN 792

Query: 779  KAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQ 833
            K +M ++ Q+Q+ H    +  E   +  T+E   E  +   +L  N G     K+E E+Q
Sbjct: 793  KDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQ 850

Query: 834  MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYI 893
             K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YI
Sbjct: 851  SKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYI 910

Query: 894  FTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAY 953
            FT  IEK+REI MSE GK+ QK+KVW  +Y+N++D IAI+ F +G  LR           
Sbjct: 911  FTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRL---------Q 961

Query: 954  DNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLS 1013
            D      GR+IYC+NII+WY+RLLD   VN+  GPYVMMIGKM+ +M Y V+IM +VL+S
Sbjct: 962  DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 1021

Query: 1014 FGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID------VCANDSVIPQI-- 1065
            FGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID          D  I Q+  
Sbjct: 1022 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPP 1081

Query: 1066 CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK 1125
            C  G W+ P + A YL V  I++VNLLIA FNN + +VK+ISN VWK+QRY  IM +HE+
Sbjct: 1082 CKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHER 1141

Query: 1126 PVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEM 1180
            PVLPPPLII SH+  +F  +C R +K     D+   G KLF+T+++ KK+HDFEEQC+E 
Sbjct: 1142 PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEE 1201

Query: 1181 YFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSA 1240
            YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K SLQ++D ++  L+DL  
Sbjct: 1202 YFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIG 1261

Query: 1241 LTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
                 L+ LT  + +E++K+ +  + + + + ++ +
Sbjct: 1262 RMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1297


>gi|154091320 transient receptor potential cation channel, subfamily
            M, member 3 isoform a [Homo sapiens]
          Length = 1554

 Score = 1369 bits (3544), Expect = 0.0
 Identities = 686/1187 (57%), Positives = 892/1187 (75%), Gaps = 62/1187 (5%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181

Query: 288  LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
            LI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++    ++
Sbjct: 182  LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241

Query: 348  STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
             TI+KTF + + +A HLF  LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242  VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301

Query: 408  FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
             DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302  PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361

Query: 468  FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCT 527
            FLTI RLEELYNT+ GP+N  L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC 
Sbjct: 362  FLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420

Query: 528  YTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPY 587
            YTRKRFR +Y++L G             P+  K+ +  G   D               P 
Sbjct: 421  YTRKRFRTLYHNLFG-------------PKRPKALKLLGMEDDI--------------PL 453

Query: 588  RPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEE 647
            R    T      KKR ++  +D+DDPE   FP+P +EL++WA LMKRQ MA F WQHGEE
Sbjct: 454  RRGRKTT-----KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 508

Query: 648  SMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMK 707
            +MAKALVACK+ ++MA+EA ++D+VDD S+EL   S DFGQLAVELL+QS++QDE +AMK
Sbjct: 509  AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 568

Query: 708  LLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILV 767
            LLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS  KVIL IL+
Sbjct: 569  LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 628

Query: 768  PPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEG- 826
            PP+IL LE+K K +M ++ Q+Q+ H    +  E   +  T+E   E  +   +L  N G 
Sbjct: 629  PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLGRNNGE 686

Query: 827  ----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLP 882
                K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+ME+ P
Sbjct: 687  SSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 746

Query: 883  SVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLR 942
            S QEWIVI+YIFT  IEK+REI MSE GK+ QK+KVW  +Y+N++D IAI+ F +G  LR
Sbjct: 747  STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 806

Query: 943  FGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFY 1002
                       D      GR+IYC+NII+WY+RLLD   VN+  GPYVMMIGKM+ +M Y
Sbjct: 807  L---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMY 857

Query: 1003 IVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID------VC 1056
             V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID        
Sbjct: 858  FVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 917

Query: 1057 ANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114
              D  I Q+  C  G W+ P + A YL V  I++VNLLIA FNN + +VK+ISN VWK+Q
Sbjct: 918  REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 977

Query: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTEEDQKK 1169
            RY  IM +HE+PVLPPPLII SH+  +F  +C R +K     D+   G KLF+T+++ KK
Sbjct: 978  RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1037

Query: 1170 LHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLD 1229
            +HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K SLQ++D
Sbjct: 1038 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1097

Query: 1230 SQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
             ++  L+DL       L+ LT  + +E++K+ +  + + + + ++ +
Sbjct: 1098 IRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1144


>gi|154091318 transient receptor potential cation channel, subfamily
            M, member 3 isoform d [Homo sapiens]
          Length = 1544

 Score = 1368 bits (3540), Expect = 0.0
 Identities = 684/1192 (57%), Positives = 888/1192 (74%), Gaps = 82/1192 (6%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181

Query: 288  LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
            LI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++    ++
Sbjct: 182  LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241

Query: 348  STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
             TI+KTF + + +A HLF  LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242  VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301

Query: 408  FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
             DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302  PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361

Query: 468  FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCT 527
            FLTI RLEELYNT+ GP+N  L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC 
Sbjct: 362  FLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420

Query: 528  YTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIK 582
            YTRKRFR +Y++L G  R     R GR T+                              
Sbjct: 421  YTRKRFRTLYHNLFGPKRDDIPLRRGRKTT------------------------------ 450

Query: 583  TAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLW 642
                             KKR ++  +D+DDPE   FP+P +EL++WA LMKRQ MA F W
Sbjct: 451  -----------------KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 493

Query: 643  QHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDE 702
            QHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL   S DFGQLAVELL+QS++QDE
Sbjct: 494  QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 553

Query: 703  TMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVI 762
             +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS  KVI
Sbjct: 554  QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 613

Query: 763  LSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILD 822
            L IL+PP+IL LE+K K +M ++ Q+Q+ H    +  E   +  T+E   E  +   +L 
Sbjct: 614  LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLG 671

Query: 823  SNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQ 877
             N G     K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+
Sbjct: 672  RNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVK 731

Query: 878  MEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFI 937
            ME+ PS QEWIVI+YIFT  IEK+REI MSE GK+ QK+KVW  +Y+N++D IAI+ F +
Sbjct: 732  MERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSV 791

Query: 938  GFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997
            G  LR           D      GR+IYC+NII+WY+RLLD   VN+  GPYVMMIGKM+
Sbjct: 792  GMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMM 842

Query: 998  ANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID--- 1054
             +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID   
Sbjct: 843  IDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPC 902

Query: 1055 ---VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNI 1109
                   D  I Q+  C  G W+ P + A YL V  I++VNLLIA FNN + +VK+ISN 
Sbjct: 903  GQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 962

Query: 1110 VWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTE 1164
            VWK+QRY  IM +HE+PVLPPPLII SH+  +F  +C R +K     D+   G KLF+T+
Sbjct: 963  VWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITD 1022

Query: 1165 EDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRS 1224
            ++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K S
Sbjct: 1023 DELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKAS 1082

Query: 1225 LQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
            LQ++D ++  L+DL       L+ LT  + +E++K+ +  + + + + ++ +
Sbjct: 1083 LQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1134


>gi|154091312 transient receptor potential cation channel, subfamily
            M, member 3 isoform b [Homo sapiens]
          Length = 1566

 Score = 1360 bits (3521), Expect = 0.0
 Identities = 686/1199 (57%), Positives = 892/1199 (74%), Gaps = 74/1199 (6%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181

Query: 288  LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
            LI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++    ++
Sbjct: 182  LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241

Query: 348  STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
             TI+KTF + + +A HLF  LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242  VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301

Query: 408  FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
             DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302  PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361

Query: 468  FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQ------------GNLPPGYKITLIDIGLV 515
            FLTI RLEELYNT+ GP+N  L+HLVRDVK+            GNLPP Y+I+LIDIGLV
Sbjct: 362  FLTISRLEELYNTRHGPSNT-LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420

Query: 516  IEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKM 575
            IEYLMGG YRC YTRKRFR +Y++L G             P+  K+ +  G   D     
Sbjct: 421  IEYLMGGAYRCNYTRKRFRTLYHNLFG-------------PKRPKALKLLGMEDDI---- 463

Query: 576  RHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQ 635
                      P R    T      KKR ++  +D+DDPE   FP+P +EL++WA LMKRQ
Sbjct: 464  ----------PLRRGRKTT-----KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 508

Query: 636  VMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLE 695
             MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL   S DFGQLAVELL+
Sbjct: 509  KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 568

Query: 696  QSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRK 755
            QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRK
Sbjct: 569  QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 628

Query: 756  NSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVF 815
            NS  KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H    +  E   +  T+E   E  
Sbjct: 629  NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDM 686

Query: 816  KEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLY 870
            +   +L  N G     K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+
Sbjct: 687  ELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLF 746

Query: 871  TFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTI 930
             ++VLV+ME+ PS QEWIVI+YIFT  IEK+REI MSE GK+ QK+KVW  +Y+N++D I
Sbjct: 747  NYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLI 806

Query: 931  AIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYV 990
            AI+ F +G  LR           D      GR+IYC+NII+WY+RLLD   VN+  GPYV
Sbjct: 807  AILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYV 857

Query: 991  MMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYA 1050
            MMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A
Sbjct: 858  MMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFA 917

Query: 1051 YEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQ 1102
             +ID          D  I Q+  C  G W+ P + A YL V  I++VNLLIA FNN + +
Sbjct: 918  DQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFE 977

Query: 1103 VKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDG 1157
            VK+ISN VWK+QRY  IM +HE+PVLPPPLII SH+  +F  +C R +K     D+   G
Sbjct: 978  VKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYG 1037

Query: 1158 PKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDR 1217
             KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R
Sbjct: 1038 LKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNER 1097

Query: 1218 VNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
             + +K SLQ++D ++  L+DL       L+ LT  + +E++K+ +  + + + + ++ +
Sbjct: 1098 EHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1156


>gi|154091316 transient receptor potential cation channel, subfamily
            M, member 3 isoform e [Homo sapiens]
          Length = 1556

 Score = 1359 bits (3517), Expect = 0.0
 Identities = 684/1204 (56%), Positives = 888/1204 (73%), Gaps = 94/1204 (7%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181

Query: 288  LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
            LI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++    ++
Sbjct: 182  LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241

Query: 348  STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
             TI+KTF + + +A HLF  LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242  VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301

Query: 408  FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
             DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302  PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361

Query: 468  FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQ------------GNLPPGYKITLIDIGLV 515
            FLTI RLEELYNT+ GP+N  L+HLVRDVK+            GNLPP Y+I+LIDIGLV
Sbjct: 362  FLTISRLEELYNTRHGPSNT-LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420

Query: 516  IEYLMGGTYRCTYTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQLRKSHESFGNRAD 570
            IEYLMGG YRC YTRKRFR +Y++L G  R     R GR T+                  
Sbjct: 421  IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTT------------------ 462

Query: 571  KKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWAC 630
                                         KKR ++  +D+DDPE   FP+P +EL++WA 
Sbjct: 463  -----------------------------KKREEEVDIDLDDPEINHFPFPFHELMVWAV 493

Query: 631  LMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLA 690
            LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL   S DFGQLA
Sbjct: 494  LMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLA 553

Query: 691  VELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGR 750
            VELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGR
Sbjct: 554  VELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGR 613

Query: 751  LNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEI 810
            L MRKNS  KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H    +  E   +  T+E 
Sbjct: 614  LRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEK 671

Query: 811  PMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLG 865
              E  +   +L  N G     K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G
Sbjct: 672  EEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIG 731

Query: 866  FLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFN 925
            +LML+ ++VLV+ME+ PS QEWIVI+YIFT  IEK+REI MSE GK+ QK+KVW  +Y+N
Sbjct: 732  YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 791

Query: 926  ISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQ 985
            ++D IAI+ F +G  LR           D      GR+IYC+NII+WY+RLLD   VN+ 
Sbjct: 792  VTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKY 842

Query: 986  AGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIF 1045
             GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+
Sbjct: 843  LGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIY 902

Query: 1046 GEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFN 1097
            GEV+A +ID          D  I Q+  C  G W+ P + A YL V  I++VNLLIA FN
Sbjct: 903  GEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFN 962

Query: 1098 NVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----D 1152
            N + +VK+ISN VWK+QRY  IM +HE+PVLPPPLII SH+  +F  +C R +K     D
Sbjct: 963  NTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPD 1022

Query: 1153 KTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIK 1212
            +   G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++
Sbjct: 1023 ERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE 1082

Query: 1213 EVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISK 1272
            EV +R + +K SLQ++D ++  L+DL       L+ LT  + +E++K+ +  + + + + 
Sbjct: 1083 EVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAA 1142

Query: 1273 HLAQ 1276
            ++ +
Sbjct: 1143 YIVR 1146


>gi|154091308 transient receptor potential cation channel, subfamily
            M, member 3 isoform f [Homo sapiens]
          Length = 1579

 Score = 1355 bits (3508), Expect = 0.0
 Identities = 686/1212 (56%), Positives = 892/1212 (73%), Gaps = 87/1212 (7%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R         
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181

Query: 279  ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
                            IGQGVPVVALI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182  RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241

Query: 323  DLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFH 382
            D+LA+ HK +EEGG + ++    ++ TI+KTF + + +A HLF  LMECMK+KELITVF 
Sbjct: 242  DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301

Query: 383  IGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQA 442
            +GS+ HQDID+AILTALLKG NASA DQL L LAW+RVDIA++ +F+YGQQW VGSLEQA
Sbjct: 302  MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361

Query: 443  MLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLP 502
            MLDALV+DRV FVKLLIENGVSMH+FLTI RLEELYNT+ GP+N  L+HLVRDVK+GNLP
Sbjct: 362  MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLP 420

Query: 503  PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSH 562
            P Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y++L G             P+  K+ 
Sbjct: 421  PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG-------------PKRPKAL 467

Query: 563  ESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPL 622
            +  G   D               P R    T      KKR ++  +D+DDPE   FP+P 
Sbjct: 468  KLLGMEDDI--------------PLRRGRKTT-----KKREEEVDIDLDDPEINHFPFPF 508

Query: 623  NELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQY 682
            +EL++WA LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL   
Sbjct: 509  HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 568

Query: 683  SNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQML 742
            S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QML
Sbjct: 569  SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 628

Query: 743  LSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENN 802
            L+DMWMGRL MRKNS  KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H    +  E  
Sbjct: 629  LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP- 687

Query: 803  FQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFW 857
             +  T+E   E  +   +L  N G     K+E E+Q K + +P+ RK Y FY+APIVKFW
Sbjct: 688  -EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFW 746

Query: 858  FNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIK 917
            F TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YIFT  IEK+REI MSE GK+ QK+K
Sbjct: 747  FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 806

Query: 918  VWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLL 977
            VW  +Y+N++D IAI+ F +G  LR           D      GR+IYC+NII+WY+RLL
Sbjct: 807  VWLQEYWNVTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLL 857

Query: 978  DFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIV 1037
            D   VN+  GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I 
Sbjct: 858  DIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIF 917

Query: 1038 FHPYWMIFGEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMV 1089
            + PYWMI+GEV+A +ID          D  I Q+  C  G W+ P + A YL V  I++V
Sbjct: 918  YMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLV 977

Query: 1090 NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRR 1149
            NLLIA FNN + +VK+ISN VWK+QRY  IM +HE+PVLPPPLII SH+  +F  +C R 
Sbjct: 978  NLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRW 1037

Query: 1150 KK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERV 1204
            +K     D+   G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERV
Sbjct: 1038 RKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERV 1097

Query: 1205 EQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEI 1264
            E M ++++EV +R + +K SLQ++D ++  L+DL       L+ LT  + +E++K+ +  
Sbjct: 1098 ENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRT 1157

Query: 1265 TRELSISKHLAQ 1276
            + + + + ++ +
Sbjct: 1158 SSDCTDAAYIVR 1169


>gi|154091310 transient receptor potential cation channel, subfamily
            M, member 3 isoform g [Homo sapiens]
          Length = 1569

 Score = 1354 bits (3504), Expect = 0.0
 Identities = 684/1217 (56%), Positives = 888/1217 (72%), Gaps = 107/1217 (8%)

Query: 108  YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
            YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168  GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
            GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228  LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
            + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R         
Sbjct: 122  MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181

Query: 279  ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
                            IGQGVPVVALI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182  RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241

Query: 323  DLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFH 382
            D+LA+ HK +EEGG + ++    ++ TI+KTF + + +A HLF  LMECMK+KELITVF 
Sbjct: 242  DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301

Query: 383  IGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQA 442
            +GS+ HQDID+AILTALLKG NASA DQL L LAW+RVDIA++ +F+YGQQW VGSLEQA
Sbjct: 302  MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361

Query: 443  MLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLP 502
            MLDALV+DRV FVKLLIENGVSMH+FLTI RLEELYNT+ GP+N  L+HLVRDVK+GNLP
Sbjct: 362  MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLP 420

Query: 503  PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQ 557
            P Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y++L G  R     R GR T+     
Sbjct: 421  PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTT----- 475

Query: 558  LRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKR 617
                                                      KKR ++  +D+DDPE   
Sbjct: 476  ------------------------------------------KKREEEVDIDLDDPEINH 493

Query: 618  FPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSE 677
            FP+P +EL++WA LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+
Sbjct: 494  FPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQ 553

Query: 678  ELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHT 737
            EL   S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHT
Sbjct: 554  ELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHT 613

Query: 738  CTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMD 797
            C+QMLL+DMWMGRL MRKNS  KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H    +
Sbjct: 614  CSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKE 673

Query: 798  DSENNFQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAP 852
              E   +  T+E   E  +   +L  N G     K+E E+Q K + +P+ RK Y FY+AP
Sbjct: 674  AEEP--EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAP 731

Query: 853  IVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKV 912
            IVKFWF TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YIFT  IEK+REI MSE GK+
Sbjct: 732  IVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKL 791

Query: 913  NQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFW 972
             QK+KVW  +Y+N++D IAI+ F +G  LR           D      GR+IYC+NII+W
Sbjct: 792  LQKVKVWLQEYWNVTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYW 842

Query: 973  YVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTL 1032
            Y+RLLD   VN+  GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW L
Sbjct: 843  YIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKL 902

Query: 1033 AKDIVFHPYWMIFGEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQ 1084
            AK+I + PYWMI+GEV+A +ID          D  I Q+  C  G W+ P + A YL V 
Sbjct: 903  AKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVA 962

Query: 1085 YIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCC 1144
             I++VNLLIA FNN + +VK+ISN VWK+QRY  IM +HE+PVLPPPLII SH+  +F  
Sbjct: 963  NILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQH 1022

Query: 1145 ICKRRKK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRV 1199
            +C R +K     D+   G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRV
Sbjct: 1023 LCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRV 1082

Query: 1200 TFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASK 1259
            T ERVE M ++++EV +R + +K SLQ++D ++  L+DL       L+ LT  + +E++K
Sbjct: 1083 TSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNK 1142

Query: 1260 VHNEITRELSISKHLAQ 1276
            + +  + + + + ++ +
Sbjct: 1143 IRSRTSSDCTDAAYIVR 1159


>gi|94538366 transient receptor potential cation channel, subfamily M,
            member 1 [Homo sapiens]
          Length = 1603

 Score = 1169 bits (3025), Expect = 0.0
 Identities = 622/1290 (48%), Positives = 856/1290 (66%), Gaps = 80/1290 (6%)

Query: 41   RCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGG 100
            RC CG+   QH     S     ++ +      Q  E+WSV KHT+  PTD+YGV+ FQGG
Sbjct: 6    RCCCGQFTNQHIPPLPSATPSKNEEESKQVETQP-EKWSVAKHTQSYPTDSYGVLEFQGG 64

Query: 101  SHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGL 160
             +S +A Y+R+SYDTKP+ +L L++K+WQ+ELPKL+ISVHGG+Q FE+ P++KQ+ GKGL
Sbjct: 65   GYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGL 124

Query: 161  IKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRD 220
            IKAA+TTGAWI TGGV+TGV  HVGDALK+H+S+S  ++C IGIAPWG++EN+ DLVG+D
Sbjct: 125  IKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKD 184

Query: 221  VVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIG 280
            V   YQT+ NPLSKL+VLNN H+HFIL D+GT+GKYGAEV+LRR LEK I+ Q+I+ R+G
Sbjct: 185  VTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLG 244

Query: 281  QGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPD 340
            QGVP+V L+ EGGPNV+  VLEYLQE PP+PVV+C+G+GRA+D+L++ HK  EEGG + +
Sbjct: 245  QGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINE 304

Query: 341  AAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALL 400
            +    ++ TI+KTFN+ + ++  LF  +MECMK+KEL+TVF +GS+  QDI++AILTALL
Sbjct: 305  SLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALL 364

Query: 401  KGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQW-LVGSLEQAMLDALVMDRVAFVKLLI 459
            KGTN SA DQL L LAW+RVDIA++ +FV+G  W  +GSL                    
Sbjct: 365  KGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATT 424

Query: 460  ENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYL 519
            + G    K     +++E    +  P    L + V  ++Q  L       +  + L+IE  
Sbjct: 425  KGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIE-- 482

Query: 520  MGGTYRCTYTRKRFRLIYNS-LGGNNRR----SGRNTSSSTPQLRKSHESFG-------- 566
             G   +   T  R   +YN+ LG  N           S+  P    S    G        
Sbjct: 483  NGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMG 542

Query: 567  -----NRADKKEKMRHNHFIKTAQPYRPKI-----DTVMEEGKKKRTK---DEI-VDIDD 612
                 N   K  +  +N+     +P   K+     D    +GKKK+ K   +EI +D+DD
Sbjct: 543  GAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD 602

Query: 613  PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672
            P   RF YP +EL++WA LMKRQ MA FLWQ GEESMAKALVACK+Y++MA+E+ +SDLV
Sbjct: 603  PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLV 662

Query: 673  DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732
            DD S++L   S DFGQLA+ELL+QS++ DE +AMKLLTYELKNWSNSTCLKLAV+++ R 
Sbjct: 663  DDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRD 722

Query: 733  FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSH--IPQSQD 790
            F+AHTC+QMLL+DMWMGRL MRKN   KVI+ IL+PP IL LE++T  + S+    +++D
Sbjct: 723  FIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENED 782

Query: 791  AHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYH 850
              +   ++++ N                    S +G  E E   K + +PI  K   FY+
Sbjct: 783  GKEKEEENTDANAD----------------AGSRKGDEENE-HKKQRSIPIGTKICEFYN 825

Query: 851  APIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAG 910
            APIVKFWF T++YLG+L+L+ +V+LV+M+  PS+QEWIVI+YI + A+EK+REI MSE G
Sbjct: 826  APIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPG 885

Query: 911  KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA-GRLIYCLNI 969
            K++QKIKVW  +Y+NI+D +AI +F IG  LR            N  ++  GR+IYC++I
Sbjct: 886  KLSQKIKVWLQEYWNITDLVAISTFMIGAILRL----------QNQPYMGYGRVIYCVDI 935

Query: 970  IFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPS 1029
            IFWY+R+LD   VN+  GPYVMMIGKM+ +M Y VVIM +VL+SFGV R+AIL+P E PS
Sbjct: 936  IFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPS 995

Query: 1030 WTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIP-------------QICGPGTWLTPFL 1076
            W LA++I + PYWMI+GEV+A +ID+ A +   P               C PG WLTP L
Sbjct: 996  WKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPAL 1055

Query: 1077 QAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILS 1136
             A YL V  I++VNLLIA FNN + +VK+ISN VWK+QRY  IM +H++PVLPPP+IILS
Sbjct: 1056 MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILS 1115

Query: 1137 HIVSLFCCICKRRKKDKTSD------GPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFH 1190
            HI  +   +  R +K +  D      G KLFL++E+ K+LH+FEEQCV+ +F EK+D+  
Sbjct: 1116 HIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQ 1175

Query: 1191 SGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLT 1250
            S S+ERIRVT ERVE M ++++E+ +R  ++K SLQ++D ++  L++LS   V+ L+ L 
Sbjct: 1176 SSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLA 1235

Query: 1251 AQKASEASKVHNEITRELSISKHLAQNLID 1280
                S+  +  +  + E   +  L Q+ I+
Sbjct: 1236 GIDRSDLIQARSRASSECEATYLLRQSSIN 1265


>gi|4507689 transient receptor potential cation channel, subfamily M,
            member 2 [Homo sapiens]
          Length = 1503

 Score =  506 bits (1302), Expect = e-142
 Identities = 389/1325 (29%), Positives = 626/1325 (47%), Gaps = 233/1325 (17%)

Query: 2    SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61
            S  SWI   + K+ECVY + SSK       G  +CQ      CG   +QH          
Sbjct: 58   SLSSWIPENIKKKECVYFVESSKLSDA---GKVVCQ------CGYTHEQHL--------- 99

Query: 62   YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
              +     H  Q  + W  +KH ++ PTDA+G I F G S   + KYVR+S DT   VI 
Sbjct: 100  --EEATKPHTFQGTQ-WDPKKHVQEMPTDAFGDIVFTGLSQKVK-KYVRVSQDTPSSVIY 155

Query: 122  QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
             L+ + W +++P L+ISV GG + F + PR+K +  +GL+K A TTGAWI+TGG +TGV 
Sbjct: 156  HLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVM 215

Query: 182  KHVGDALKEHASRSSRK---ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNP--LSKLN 236
            K VG+A+++ +  SS K   + TIG+A WG +  R  L+      P + +L+      L 
Sbjct: 216  KQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLT 275

Query: 237  VLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQ-RIHARIGQGVPVVALIFEGGPN 295
             L++ HSHFILVDDGT G+YG E+ LR  LEK I++Q +    +   +P+V ++ EGGP 
Sbjct: 276  CLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPG 335

Query: 296  VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDI-ISTIKKTF 354
             + T+          P VV EG+GR AD++A +        NLP +   DI IS I++  
Sbjct: 336  TLHTIDNATTNG--TPCVVVEGSGRVADVIAQV-------ANLPVS---DITISLIQQKL 383

Query: 355  N---------FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNA 405
            +         F ++  +   + + + ++R++L+TVF  G D  QD+DVAIL ALLK + +
Sbjct: 384  SVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRS 443

Query: 406  SAF-------DQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLL 458
                       QL L +AW+RVDIA++ +F+   QW    L   M  AL+ ++  FVKL 
Sbjct: 444  QDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLF 503

Query: 459  IENGVSMHKFLTIPRLEELYNTKQGPTNPMLFH------LVRDVKQGNLPPGY-KITLID 511
            +ENGV + +F+T   L  LY          LFH      LV D ++    P   ++ +  
Sbjct: 504  LENGVQLKEFVTWDTLLYLYENLDPSC---LFHSKLQKVLVEDPERPACAPAAPRLQMHH 560

Query: 512  IGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADK 571
            +  V+  L+G   +  Y R R                                       
Sbjct: 561  VAQVLRELLGDFTQPLYPRPR--------------------------------------- 581

Query: 572  KEKMRHNHFIKTAQPY---RPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIW 628
                 HN  ++   P    +  +  V      KR+   +    DP        + +LLIW
Sbjct: 582  -----HNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDP--------IRDLLIW 628

Query: 629  ACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQ 688
            A +  R+ +A  +W   ++ +A AL   KI + ++ E + +D    +SEE+   + ++  
Sbjct: 629  AIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTD----SSEEMLALAEEYEH 684

Query: 689  LAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWM 748
             A+ +  + +R+DE  A KLLT   + W  +TCL+LA+ ++   FV+H   Q  L+ +W 
Sbjct: 685  RAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWW 744

Query: 749  GRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITE 808
            G+L++    W +V L +L  P +L                                    
Sbjct: 745  GQLSVDNGLW-RVTLCMLAFPLLLT----------------------------------- 768

Query: 809  EIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLM 868
               +  F+E R+ D                 P  R   AF+ AP+V F  N L+Y  FL 
Sbjct: 769  --GLISFREKRLQDVGT--------------PAARA-RAFFTAPVVVFHLNILSYFAFLC 811

Query: 869  LYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMS--EAGKVNQKIKVWFSDYFNI 926
            L+ +V++V  + +PS  E  +  ++F+   E++R++F    E G + +K  ++FSD++N 
Sbjct: 812  LFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLM-KKAALYFSDFWNK 870

Query: 927  SDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQA 986
             D  AI+ F  G   R       A  Y       GR+I  L+ I + +RL+    +++  
Sbjct: 871  LDVGAILLFVAGLTCRLIP----ATLYP------GRVILSLDFILFCLRLMHIFTISKTL 920

Query: 987  GPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFG 1046
            GP ++++ +M+ ++F+ + ++A+ ++SFGV ++AIL  +E     L +  V+H Y  IFG
Sbjct: 921  GPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFG 980

Query: 1047 EVYAYEIDVCANDSVIPQICGP-GT---------------------WLTPFLQAVYLFVQ 1084
            ++  Y   V  N    P+ C P GT                     WLT  L  +YL   
Sbjct: 981  QIPGYIDGVNFN----PEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFT 1036

Query: 1085 YIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCC 1144
             I+++NLLIA FN  + QV+  ++ +WK+QR+  I  YH +P  PPP I+LSH+  LF  
Sbjct: 1037 NILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHL-QLFIK 1095

Query: 1145 ICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERV 1204
                +   K     K  L + ++  L  +E    E Y   +  +     E++I     +V
Sbjct: 1096 RVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKV 1155

Query: 1205 EQMCIQIKEVG--DRVNYIKRSLQSLDSQIGHLQDLSALTVDTLK-----------TLTA 1251
            + M + + ++    R   +++ L SL+ Q+          V TL+           TL +
Sbjct: 1156 DAM-VDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFSSEADVPTLAS 1214

Query: 1252 QKASE 1256
            QKA+E
Sbjct: 1215 QKAAE 1219


>gi|11225266 transient receptor potential cation channel, subfamily M,
            member 5 [Homo sapiens]
          Length = 1165

 Score =  418 bits (1074), Expect = e-116
 Identities = 333/1192 (27%), Positives = 562/1192 (47%), Gaps = 132/1192 (11%)

Query: 93   GVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRI 152
            G +NF GGS   R K+VR+     P V+  LLL EW +  P LV+S+ G  Q F +   +
Sbjct: 26   GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84

Query: 153  KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEH--ASRSSR-KICTIGIAPWGV 209
            + +L KGL+KAA +TGAWILT  +  G+A+HVG A+++H  AS S++ ++  +G+A  G 
Sbjct: 85   RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144

Query: 210  IENRNDL--VGRDVVAPYQT----LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263
            + +R  L     D    Y         PL  L+  +NL SHFILV+ G  GK      LR
Sbjct: 145  VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLD--SNL-SHFILVEPGPPGKGDGLTELR 201

Query: 264  RELEKTINQQRIHARIGQG---VPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGR 320
              LEK I++QR     G G   +PV+ L+  G PN +  +   ++++ P  ++V  G+G 
Sbjct: 202  LRLEKHISEQRAGYG-GTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGG 258

Query: 321  AADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITV 380
             AD+LA +  Q      +P  AE           +F   + +   + L      + L+TV
Sbjct: 259  IADVLAALVNQPHL--LVPKVAEKQFKEKFPSK-HFSWEDIVRWTKLLQNITSHQHLLTV 315

Query: 381  FHIGSDEHQDIDVAILTALLKGTNASA------FDQLILTLAWDRVDIAKNHVFVYGQQW 434
            +    +  +++D  IL AL+K   + +       D+L L +AWDRVDIAK+ +F    +W
Sbjct: 316  YDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEW 375

Query: 435  LVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVR 494
                LE+ M+DALV ++  FV+L ++NG  +  FLT  RL+ELY +    +  +LF L++
Sbjct: 376  KSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS--LLFDLLQ 433

Query: 495  DVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSS 554
              ++                                   RL    LG    R       +
Sbjct: 434  RKQE---------------------------------EARLTLAGLGTQQARE----PPA 456

Query: 555  TPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDE--IVDIDD 612
             P     HE      D  +      +    Q  RP      E+G  KR   +  ++D++ 
Sbjct: 457  GPPAFSLHEVSRVLKDFLQDACRGFY----QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQ 512

Query: 613  PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672
                    P  +L +WA L  R  MA + W  G+E +A AL ACKI + M++   +++  
Sbjct: 513  KSEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAA 568

Query: 673  DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732
              T E        + +LA++L  + +   E  A  LL    + WS +TCL LA  +  + 
Sbjct: 569  RATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKA 622

Query: 733  FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQS-QDA 791
            F AH   Q  L+ +W G  +M   +    +L   + PA++     T +E + +    +D 
Sbjct: 623  FFAHDGVQAFLTRIWWG--DMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDL 680

Query: 792  HQMTMDDSENN----FQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYA 847
              +   D+E +     Q+  EE+      E      + G   + +  + +K         
Sbjct: 681  QDLDSLDTEKSPLYGLQSRVEELV-----EAPRAQGDRGPRAVFLLTRWRK--------- 726

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQME---QLPSVQEWIVIAYIFTYAIEKVRE- 903
            F+ AP+  F  N + Y  FL L+T+V+LV      Q PS  E  +  ++FT  +E++R+ 
Sbjct: 727  FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786

Query: 904  IFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRL 963
             F  E   + +K  ++  D +N  D +AI  F +G   R               F AGR 
Sbjct: 787  FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPS----------AFEAGRT 836

Query: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
            +  ++ + + +RL+   A+++Q GP ++++ +M+ ++F+ +  +++ L+++GV  +A+L+
Sbjct: 837  VLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH 896

Query: 1024 PHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC-ANDSVIPQICGPG--------TWLTP 1074
            PH+     + + +++ PY  IFG++   EID    N S  P +             WL  
Sbjct: 897  PHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956

Query: 1075 FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLII 1134
             L   +L V  ++++NLLIA F+  +  V+  +++ WK+QRY+ I+ YHE+P L PP I+
Sbjct: 957  LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFIL 1016

Query: 1135 LSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSE 1194
            LSH+      + K+  + K     +      DQK +  +E    E + ++ + +      
Sbjct: 1017 LSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVV-TWETVQKENFLSKMEKRRRDSEG 1075

Query: 1195 ERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTL 1246
            E +R T  RV+ +    K +G      KR ++ L+SQI +   L +   D L
Sbjct: 1076 EVLRKTAHRVDFIA---KYLGGLREQEKR-IKCLESQINYCSVLVSSVADVL 1123


>gi|45935368 transient receptor potential cation channel, subfamily
           M, member 3 isoform h [Homo sapiens]
          Length = 230

 Score =  362 bits (929), Expect = 2e-99
 Identities = 167/229 (72%), Positives = 206/229 (89%)

Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
           YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
           GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
           + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181

Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGG 336
           LI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230


>gi|55953096 transient receptor potential cation channel, subfamily
           M, member 3 isoform c [Homo sapiens]
          Length = 255

 Score =  348 bits (893), Expect = 3e-95
 Identities = 167/254 (65%), Positives = 206/254 (81%), Gaps = 25/254 (9%)

Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
           YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
           GAWI TGGVNTGV +HVGDALK+HAS+S  KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121

Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
           + NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R         
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181

Query: 279 ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
                           IGQGVPVVALI EGGPNVI  VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241

Query: 323 DLLAYIHKQTEEGG 336
           D+LA+ HK +EEGG
Sbjct: 242 DILAFGHKYSEEGG 255


>gi|21314671 transient receptor potential cation channel, subfamily
           M, member 4 [Homo sapiens]
          Length = 1214

 Score =  255 bits (651), Expect = 3e-67
 Identities = 183/537 (34%), Positives = 280/537 (52%), Gaps = 49/537 (9%)

Query: 3   QKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKY 62
           ++SWI     K+ C   I  S DP     G  +CQ      CGR    H           
Sbjct: 7   EQSWIPKIFKKKTCTTFIVDSTDP-----GGTLCQ------CGRPRTAHPA--------- 46

Query: 63  SDVKLGDHFNQAIEE-WSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
             V + D F  A+   W  + HT + PTDAYG ++F G    + + ++RLS  T P  + 
Sbjct: 47  --VAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKH-SNFLRLSDRTDPAAVY 103

Query: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
            L+ + W    P LV+SV GG     L   ++ LL +GL++AA +TGAWI+TGG++TG+ 
Sbjct: 104 SLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIG 163

Query: 182 KHVGDALKEH--ASRSSRKICTIGIAPWGVIENRNDLVG--RDVVAPYQTLLNPLSKLNV 237
           +HVG A+++H  AS    K+  +G+APWGV+ NR+ L+       A Y+   +P   +  
Sbjct: 164 RHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQF 223

Query: 238 -LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPN 295
            L+  +S F LVDDGT G  G E R R  LE  I+QQ+      G  +PV+ L+ +G   
Sbjct: 224 PLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEK 283

Query: 296 VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN 355
           ++  +    Q    +P ++  G+G AAD LA   + T   G+   A + +    I++ F 
Sbjct: 284 MLTRIENATQAQ--LPCLLVAGSGGAADCLAETLEDTLAPGS-GGARQGEARDRIRRFFP 340

Query: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLK---GTNASAF-DQL 411
            G  E L     +   M RKEL+TV+    D  ++ +  +L AL+K    + ASA+ D+L
Sbjct: 341 KGDLEVLQ--AQVERIMTRKELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDEL 397

Query: 412 ILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTI 471
            L +AW+RVDIA++ +F    QW    LE +++DAL+ DR  FV+LLI +G+S+  FLT 
Sbjct: 398 RLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTP 457

Query: 472 PRLEELYNTKQGPTNPMLFHLVRDVKQ--GNLPPGYK-----ITLIDIGLVIEYLMG 521
            RL +LY+    P+N ++ +L+       G   P  K     +   D+G V+  L+G
Sbjct: 458 MRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLG 512



 Score =  239 bits (611), Expect = 1e-62
 Identities = 166/653 (25%), Positives = 313/653 (47%), Gaps = 63/653 (9%)

Query: 621  PLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELK 680
            P ++LL+WA L+ R  MA + W+ G  +++ AL AC + R MA     ++     +   K
Sbjct: 558  PWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAE----EAARRK 613

Query: 681  QYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQ 740
              +  F  + V+L  + +R  E  A +LL      W ++TCL+LA+ +  R F A    Q
Sbjct: 614  DLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQ 673

Query: 741  MLLSDMWMGRLNMRKNSWYKVILSILVPPAI---LLLEYKTKAEMSHIPQSQDAHQMTMD 797
             LL+  W G +      W  ++L+   PP I   L+   K++ E +      D   +   
Sbjct: 674  SLLTQKWWGDMASTTPIW-ALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVING 732

Query: 798  DSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFW 857
            +      +  E+ P+ V ++        G        +       R+++ F+ AP+  F 
Sbjct: 733  EGPVGTADPAEKTPLGVPRQSGRPGCCGG--------RCGGRRCLRRWFHFWGAPVTIFM 784

Query: 858  FNTLAYLGFLMLYTFVVLVQMEQL-PSVQEWIVIAYIFTYAIEKVREIFMSEAG------ 910
             N ++YL FL+L++ V+LV  +   P   E ++  + FT   E++R+      G      
Sbjct: 785  GNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGG 844

Query: 911  ------KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
                   ++Q+++++ +D +N  D +A+  F +G G R              ++  GR +
Sbjct: 845  PGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL----------TPGLYHLGRTV 894

Query: 965  YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
             C++ + + VRLL    VN+Q GP ++++ KM+ ++F+ +  + + L+++GV  + +L P
Sbjct: 895  LCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRP 954

Query: 1025 HEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC----ANDSVIPQICG--PG--------- 1069
             ++   ++ + + + PY  IFG++   ++DV     +N S  P      PG         
Sbjct: 955  RDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQ 1014

Query: 1070 --TWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPV 1127
               WL   L  ++L V  I++VNLLIA F+  + +V+  S++ WK QRY  I  +H +P 
Sbjct: 1015 YANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPA 1074

Query: 1128 LPPPLIILSHIVSLFCCICKRRKKDKTSDGP----KLFLTEEDQKKLHDFEEQCVEMYFN 1183
            L PP I++SH+  L   +C+R +  + S       +++L++E ++KL  +E    E +  
Sbjct: 1075 LAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLL 1134

Query: 1184 EKDDKFHSGSEERIRVTFERVEQMCIQ---IKEVGDRVNYIKRSLQSLDSQIG 1233
             +         ER++ T ++V+    Q   I+E   R+  ++R +Q     +G
Sbjct: 1135 ARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLG 1187


>gi|109689695 transient receptor potential cation channel, subfamily
           M, member 8 [Homo sapiens]
          Length = 1104

 Score =  240 bits (612), Expect = 1e-62
 Identities = 158/490 (32%), Positives = 262/490 (53%), Gaps = 49/490 (10%)

Query: 5   SWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSD 64
           ++I++   KRECV+    SK                 C CG    QH             
Sbjct: 43  NFIQANFKKRECVFFTKDSKATENV------------CKCGYAQSQHM------------ 78

Query: 65  VKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLL 124
              G   NQ+ E+W+ +KHT++ PTDA+G I F+  +   + KY+RLS DT  E++ +LL
Sbjct: 79  --EGTQINQS-EKWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIRLSCDTDAEILYELL 133

Query: 125 LKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHV 184
            + W ++ P LVISV GG + F L PR++++  + LI  A + GAWILTGG + G+ K++
Sbjct: 134 TQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYI 192

Query: 185 GDALKEHA-SRSSRK-ICTIGIAPWGVIENRNDLVGRDVVAPY---QTLLNPLSK--LNV 237
           G+ ++++  SRSS + I  IGIA WG++ NR+ L+       Y   Q L++  ++  L +
Sbjct: 193 GEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYI 252

Query: 238 LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPNV 296
           L+N H+H +LVD+G  G    E +LR +LEK I+++ I  +  G  +P+V     GG   
Sbjct: 253 LDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKET 312

Query: 297 ILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN- 355
           +  +   ++    +P VV EG+G+ AD++A + +   E      A +  ++  + +T + 
Sbjct: 313 LKAINTSIKNK--IPCVVVEGSGQIADVIASLVEV--EDALTSSAVKEKLVRFLPRTVSR 368

Query: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFD------ 409
             + E     + L E ++   L+TV  +     + +  AI  AL K  + S  D      
Sbjct: 369 LPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNG 428

Query: 410 QLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFL 469
           QL L L W+++D+A + +F   ++W    L++ M  AL+ DR  FV+L +ENG+++ KFL
Sbjct: 429 QLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFL 488

Query: 470 TIPRLEELYN 479
           T   L EL++
Sbjct: 489 THDVLTELFS 498



 Score =  147 bits (372), Expect = 7e-35
 Identities = 98/400 (24%), Positives = 198/400 (49%), Gaps = 49/400 (12%)

Query: 845  FYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREI 904
            + AF+ +P V F +N + Y+ FL+L+ +V+L+    +P   E ++ + +F    ++VR+ 
Sbjct: 727  YVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQW 786

Query: 905  FMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
            +++           +F+D +N+ DT+ +  F  G   R  +  N ++ Y      +GR+I
Sbjct: 787  YVNGVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSS-NKSSLY------SGRVI 831

Query: 965  YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
            +CL+ I + +RL+    V++  GP ++M+ +M+ ++F+ + + A+ +++FGV R+ IL  
Sbjct: 832  FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQ 891

Query: 1025 HEAPSWTLAKDIVFHPYWMIFGEV------YAYEIDVCA-------------NDSVIPQI 1065
            +E     + + +++ PY  +FG+V        Y+   C              ++  +P+ 
Sbjct: 892  NEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRF 951

Query: 1066 CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK 1125
                 W+T  L  +Y+    I++VNLL+A F      V+  ++ VWK+QRY  +  Y  +
Sbjct: 952  ---PEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR 1008

Query: 1126 PVLPPPLIILSH----IVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMY 1181
              +P P I+ ++    +   F C C    K+K  +        ED + L  +E    E Y
Sbjct: 1009 LNIPFPFIVFAYFYMVVKKCFKCCC----KEKNMESSVCCFKNEDNETL-AWEGVMKENY 1063

Query: 1182 FNEKDDKFHSGSEE---RIRVTFERVEQMCIQIKEVGDRV 1218
              + + K +  SEE   R R    ++  +   +KE+ +++
Sbjct: 1064 LVKINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKI 1103



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 48/152 (31%), Positives = 80/152 (52%), Gaps = 5/152 (3%)

Query: 620 YPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEEL 679
           +PL  L IWA L  ++ +++ +W+        AL A K+ +++A + K        SEEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLA-KVKNDINAAGESEEL 617

Query: 680 KQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCT 739
              +N++   AVEL  + +  DE +A +LL Y  + W  S CL+LAV +  + F+A    
Sbjct: 618 ---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674

Query: 740 QMLLSDMWMGRLNMRKNSWYKVILSILVPPAI 771
           Q  LS  W G ++    +W K+IL + + P +
Sbjct: 675 QNFLSKQWYGEISRDTKNW-KIILCLFIIPLV 705


>gi|209863032 transient receptor potential cation channel, subfamily
            C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 185  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 244

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 245  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 300

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 301  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 360

Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 361  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 418

Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 419  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 469

Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
             M+Y E+   LP P  ++    SL+  I       CK++ + K    P+ F T      +
Sbjct: 470  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 525

Query: 1166 DQKKLHDFEE 1175
            + ++ H ++E
Sbjct: 526  NLRRHHQYQE 535


>gi|209863030 transient receptor potential cation channel, subfamily
            C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533

Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591

Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642

Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
             M+Y E+   LP P  ++    SL+  I       CK++ + K    P+ F T      +
Sbjct: 643  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698

Query: 1166 DQKKLHDFEE 1175
            + ++ H ++E
Sbjct: 699  NLRRHHQYQE 708


>gi|209863026 transient receptor potential cation channel, subfamily
            C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533

Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591

Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642

Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
             M+Y E+   LP P  ++    SL+  I       CK++ + K    P+ F T      +
Sbjct: 643  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698

Query: 1166 DQKKLHDFEE 1175
            + ++ H ++E
Sbjct: 699  NLRRHHQYQE 708


>gi|7706747 transient receptor potential cation channel, subfamily C,
            member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533

Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591

Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642

Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
             M+Y E+   LP P  ++    SL+  I       CK++ + K    P+ F T      +
Sbjct: 643  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698

Query: 1166 DQKKLHDFEE 1175
            + ++ H ++E
Sbjct: 699  NLRRHHQYQE 708


>gi|209863024 transient receptor potential cation channel, subfamily
            C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 80/343 (23%), Positives = 148/343 (43%), Gaps = 52/343 (15%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533

Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591

Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642

Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDK 1153
             M+Y E+   LP P  ++    SL+  I       CK++ + K
Sbjct: 643  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK 685


>gi|6912736 transient receptor potential cation channel, subfamily C,
            member 5 [Homo sapiens]
          Length = 973

 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 70/324 (21%), Positives = 138/324 (42%), Gaps = 54/324 (16%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQL-----------PSVQEWIVIAYIFTY 896
            F   P +KF  +T +YL FL    F++L+  + +           P+V EW+++ ++  +
Sbjct: 359  FIKKPFIKFICHTASYLTFL----FMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGF 414

Query: 897  AIEKVREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYD 954
               +++E++    G   + I  W++  D+   S  +A IS  I   +++           
Sbjct: 415  IWGEIKEMW---DGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471

Query: 955  NHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF 1014
             H  +    ++ ++ I   +RL+     N   GP  + +G+M+ ++   + I  LVLL+F
Sbjct: 472  WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531

Query: 1015 GVPRKAILYPHEAPS------------------WTLAKDIVFHPYWMIFGEVYAYEIDVC 1056
                  + + +E  +                  ++   + +   +W +FG +  Y  +V 
Sbjct: 532  ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591

Query: 1057 ANDSVIPQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWK 1112
            A               T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK
Sbjct: 592  ARHE-----------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWK 640

Query: 1113 YQRYHFIMAY-HEKPVLPPPLIIL 1135
            + R    M+Y  E   LPPP  I+
Sbjct: 641  FARTKLWMSYFDEGGTLPPPFNII 664


>gi|148596992 heart alpha-kinase [Homo sapiens]
          Length = 2170

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 48/138 (34%), Positives = 65/138 (47%), Gaps = 18/138 (13%)

Query: 1700 PRFLEVFLLYCHSAGQWFA-VEECMTGEFRKYNNNNGDEIIPTNTLEEI---MLAFSHWT 1755
            P  + +FL++       +A VEE + GEF KY+  +G EI       E       F HW 
Sbjct: 2009 PEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWV 2068

Query: 1756 YEYTRGELLVLDLQGVGENLTDPSVIKAEE-----KRSCDMVFGPANLGEDAIKNFRAKH 1810
            Y+ T G LLV D+QGVG  LTD  +    +     K +C M F         I  F+A H
Sbjct: 2069 YQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTF---------IDQFKALH 2119

Query: 1811 HCNSCCRKLKLPDLKRND 1828
             CN  C+ L L  L+ N+
Sbjct: 2120 QCNKYCKMLGLKSLQNNN 2137


>gi|209863028 transient receptor potential cation channel, subfamily
            C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 66/303 (21%), Positives = 133/303 (43%), Gaps = 45/303 (14%)

Query: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417

Query: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473

Query: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF--- 1014
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533

Query: 1015 ------------GVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVI 1062
                        G+  K I    +  +++   + +   +W IFG +  Y  +V A     
Sbjct: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591

Query: 1063 PQICGPGTWLTPFLQA----VYLFVQYIIMVNLLIAFFNNVY-LQVKAISNIVWKYQRYH 1117
                      T F+ A     Y  +  ++++N+LIA  NN Y L  +  ++ + ++ +Y 
Sbjct: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQ 642

Query: 1118 FIM 1120
             +M
Sbjct: 643  EVM 645


>gi|9558749 elongation factor-2 kinase [Homo sapiens]
          Length = 725

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 7/105 (6%)

Query: 1717 FAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLT 1776
            F +E  + G++ KYN+N+G   +  + +     AFSH+T+E +  +L+V+D+QGVG+  T
Sbjct: 226  FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYT 283

Query: 1777 DPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKL 1821
            DP +     +   D  FG  NLG   +  F   H CN  C  + L
Sbjct: 284  DPQI---HTETGTD--FGDGNLGVRGMALFFYSHACNRICESMGL 323


>gi|5730102 transient receptor potential cation channel, subfamily C,
            member 6 [Homo sapiens]
          Length = 931

 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 43/192 (22%), Positives = 89/192 (46%), Gaps = 12/192 (6%)

Query: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAI-- 1021
            +Y + ++  + R+   L  N+  GP  + +G+ V ++F  +VI  +V ++F +    +  
Sbjct: 598  LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 657

Query: 1022 --LYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAV 1079
              +   +  ++T  ++     +W IFG      + +  N   I  I          L  V
Sbjct: 658  YYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENI-------GYVLYGV 710

Query: 1080 YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSHI 1138
            Y     I+++N+LIA  N+ + +++  +++ WK+ R     +Y E+   LP P  ++   
Sbjct: 711  YNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSP 770

Query: 1139 VSLFCCICKRRK 1150
             SLF  + K +K
Sbjct: 771  KSLFYLLLKLKK 782


>gi|9966865 transient receptor potential cation channel, subfamily C,
            member 7 [Homo sapiens]
          Length = 862

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 12/189 (6%)

Query: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
            +Y + ++  + R+   L  N+  GP  + +G+ V ++F  +VI  +V ++F +    +  
Sbjct: 543  LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 602

Query: 1024 PHEA----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAV 1079
             +      P++T  ++     +W IFG      + +  +   I  I          L  V
Sbjct: 603  YYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENI-------GYVLYGV 655

Query: 1080 YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAY-HEKPVLPPPLIILSHI 1138
            Y     ++++N+LIA  NN Y +++  +++ WK+ R    ++Y  E   LP P  ++   
Sbjct: 656  YNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSP 715

Query: 1139 VSLFCCICK 1147
             S +  I +
Sbjct: 716  KSFYYLIMR 724


>gi|194733735 transient receptor potential cation channel, subfamily
            C, member 3 isoform a [Homo sapiens]
          Length = 921

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 22/204 (10%)

Query: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
            +Y + ++  + R+   L  N+  GP  + +G+ V ++F  +V+  +V  +F +    ILY
Sbjct: 614  LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 672

Query: 1024 PHEA-----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQA 1078
             +        ++T  ++     +W IFG      + +  +   I  I          L  
Sbjct: 673  SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 725

Query: 1079 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSH 1137
            +Y     ++++N+LIA  N+ Y +++  S++ WK+ R    ++Y +    LPPP  ++  
Sbjct: 726  IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 785

Query: 1138 IVSLFCCI--------CKRRKKDK 1153
              S    I        C+RR+  K
Sbjct: 786  PKSFVYFIMRIVNFPKCRRRRLQK 809


>gi|4507687 transient receptor potential cation channel, subfamily C,
            member 3 isoform b [Homo sapiens]
          Length = 848

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 22/204 (10%)

Query: 964  IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
            +Y + ++  + R+   L  N+  GP  + +G+ V ++F  +V+  +V  +F +    ILY
Sbjct: 541  LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 599

Query: 1024 PHEA-----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQA 1078
             +        ++T  ++     +W IFG      + +  +   I  I          L  
Sbjct: 600  SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 652

Query: 1079 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSH 1137
            +Y     ++++N+LIA  N+ Y +++  S++ WK+ R    ++Y +    LPPP  ++  
Sbjct: 653  IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 712

Query: 1138 IVSLFCCI--------CKRRKKDK 1153
              S    I        C+RR+  K
Sbjct: 713  PKSFVYFIMRIVNFPKCRRRRLQK 736


>gi|156151443 alpha-kinase 1 [Homo sapiens]
          Length = 1244

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 24/175 (13%)

Query: 1662 YKEDTVLHLCLREIQQQRAAQKLTFAFN-----QMKPKSIPYSPRFLEVFLLYCHSAGQW 1716
            YKE   L     ++++Q  AQ     FN     Q  P  I Y P  + + +L   +    
Sbjct: 1069 YKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTI-LLILEDKTIKGC 1127

Query: 1717 FAVEECMTGEFRKYNNNNGDEIIPTN-TLEEIMLAFSHWTYEYTRGELLVLDLQG-VGEN 1774
             +VE  + GEF K +NN   +++ T     E  LA+ H++YE++    +V+DLQG V  N
Sbjct: 1128 ISVEPYILGEFVKLSNNT--KVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGN 1185

Query: 1775 ------LTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHH--CNSCCRKLKL 1821
                  LTDP +   ++K     VF   N G+  I  F    H  CN  C +L L
Sbjct: 1186 GKGLIYLTDPQIHSVDQK-----VF-TTNFGKRGIFYFFNNQHVECNEICHRLSL 1234


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,917,602
Number of Sequences: 37866
Number of extensions: 3299069
Number of successful extensions: 8493
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 8244
Number of HSP's gapped (non-prelim): 184
length of query: 1865
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1748
effective length of database: 13,817,196
effective search space: 24152458608
effective search space used: 24152458608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.