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Search of human proteins with 146229324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
(507 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 1055 0.0
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 1055 0.0
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 1055 0.0
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 1055 0.0
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 887 0.0
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 268 7e-72
gi|45430057 Arylsulfatase G [Homo sapiens] 267 2e-71
gi|157266309 arylsulfatase E precursor [Homo sapiens] 233 4e-61
gi|31742482 arylsulfatase F precursor [Homo sapiens] 219 6e-57
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 152 9e-37
gi|59797060 arylsulfatase family, member I [Homo sapiens] 150 3e-36
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 149 4e-36
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 147 3e-35
gi|58743319 arylsulfatase family, member H [Homo sapiens] 134 2e-31
gi|109389362 arylsulfatase J [Homo sapiens] 133 4e-31
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 124 2e-28
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 124 2e-28
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 99 9e-21
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 72 1e-12
gi|39930577 arylsulfatase K [Homo sapiens] 66 9e-11
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 64 2e-10
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 64 2e-10
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 64 2e-10
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 63 6e-10
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 63 6e-10
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 47 5e-05
gi|189571643 sulfatase 1 [Homo sapiens] 46 7e-05
gi|189571641 sulfatase 1 [Homo sapiens] 46 7e-05
gi|189571638 sulfatase 1 [Homo sapiens] 46 7e-05
gi|189571636 sulfatase 1 [Homo sapiens] 46 7e-05
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 1055 bits (2727), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
Sbjct: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
Query: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
Sbjct: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
Query: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
Sbjct: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
Query: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
Sbjct: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
Query: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
EDPALQICCHPGCTPRPACCHCPDPHA
Sbjct: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 1055 bits (2727), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
Sbjct: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
Query: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
Sbjct: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
Query: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
Sbjct: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
Query: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
Sbjct: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
Query: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
EDPALQICCHPGCTPRPACCHCPDPHA
Sbjct: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 1055 bits (2727), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
Sbjct: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
Query: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
Sbjct: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
Query: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
Sbjct: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
Query: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
Sbjct: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
Query: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
EDPALQICCHPGCTPRPACCHCPDPHA
Sbjct: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 1055 bits (2727), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
Sbjct: 1 MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180
Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300
Query: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
Sbjct: 301 GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360
Query: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
Sbjct: 361 LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420
Query: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
Sbjct: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG 480
Query: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
EDPALQICCHPGCTPRPACCHCPDPHA
Sbjct: 481 EDPALQICCHPGCTPRPACCHCPDPHA 507
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 85 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
Query: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
Query: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 264
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
Query: 265 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 324
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
Query: 325 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 384
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
Query: 385 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 444
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
Query: 445 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 504
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
Query: 505 PHA 507
PHA
Sbjct: 421 PHA 423
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 268 bits (686), Expect = 7e-72
Identities = 195/533 (36%), Positives = 275/533 (51%), Gaps = 69/533 (12%)
Query: 7 LLLALAAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
LL+ AAG+ + +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY
Sbjct: 14 LLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFY 73
Query: 64 VPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSSR-GGLPLEEVTVAEVLAARGY 116
LC+PSRAALLTGRLP+R G Y P GG+P E + E+L GY
Sbjct: 74 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGY 133
Query: 117 LTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL 176
++ + GKWHLG P+ F P GF + G P H GP N P P +
Sbjct: 134 VSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWE--- 185
Query: 177 VPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQ 232
+ E P L EA Y+ A D + Q + PFFLY+A TH P
Sbjct: 186 -----MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQARHHPFFLYWAVDATHAPV 239
Query: 233 FSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SR 291
++ + F S RG +GD++ E+D ++G ++ + DL + + T V FT+DNG + +
Sbjct: 240 YASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
Query: 292 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLP 349
GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L S +DL T ALAG P
Sbjct: 300 GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359
Query: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFT-QGSAHS 406
+ +DG +L P LL G+ + +F+Y RG + A G++KAHF+T S +
Sbjct: 360 DRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWEN 411
Query: 407 DTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
C S +T H + PL++ L +DPGE + L + A+ E +AL +
Sbjct: 412 FRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSR 467
Query: 459 LQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPACCHCPD 504
+ + Q A+ P+Q P L +C PGC C P+
Sbjct: 468 ITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 512
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 267 bits (682), Expect = 2e-71
Identities = 189/507 (37%), Positives = 254/507 (50%), Gaps = 47/507 (9%)
Query: 13 AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPS 72
+G + PN V+I ADD+G+GDLG + T NLD++A+ G+RF DF+ S C+PS
Sbjct: 28 SGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPS 87
Query: 73 RAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
RA+LLTGRL +R G+ V +S GGLPL E T+AEVL GY+TG+ GKWHL G G
Sbjct: 88 RASLLTGRLGLRNGVTRNFAV-TSVGGLPLNETTLAEVLQQAGYVTGIIGKWHL--GHHG 144
Query: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP----PATPCDGGCDQGL-------VPIPL 181
++ P +GF + GIPYSHD G C + + PA P G + L V +PL
Sbjct: 145 SYHPNFRGFDYYFGIPYSHDMG-CTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPL 203
Query: 182 LANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAER 241
NL++ QP L L +Y A + A RPF LY A H H P Q A
Sbjct: 204 YENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAP 263
Query: 242 SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSG----- 296
GR +G L E+D+ VG + + D + E T + FT DNGP + G G
Sbjct: 264 RGRSLYGAGLWEMDSLVGQIKDKV-DHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGF 322
Query: 297 -LLRCG----KGTTYEGGVREPALAFWPGHIAPGVTH-ELASSLDLLPTLAALAGAPLP- 349
R G K TT+EGG R PALA+WPG + VT L S LD+ PT+ ALA A LP
Sbjct: 323 WQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQ 382
Query: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPS--YPDEVRGVFAVRTGKYKAHFFTQGSAHSD 407
DG D+S +L G + P + F+P+ E + VR +YKA + T G+ D
Sbjct: 383 GRRFDGVDVSEVLFGRSQ-PGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACD 441
Query: 408 TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVA---GATPEVLQALKQLQLLKA 464
+ P H+ PL+++L D E L G A PEV + L +
Sbjct: 442 GSTGPELQ-------HKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADV----- 489
Query: 465 QLDAAVTFGPSQVARGEDPALQICCHP 491
L S +DP++ CC+P
Sbjct: 490 -LQDIANDNISSADYTQDPSVTPCCNP 515
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 233 bits (593), Expect = 4e-61
Identities = 182/561 (32%), Positives = 262/561 (46%), Gaps = 79/561 (14%)
Query: 6 SLLLALAAGLAV---ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62
++LL+LA + A PNI+L+ ADDLG GD+GCYG+ + TPN+D+LA G++ T
Sbjct: 20 AVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQH 79
Query: 63 YVPVSLCTPSRAALLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYL 117
SLCTPSRAA LTGR PVR GM Y + + GGLP E T A++L +GY
Sbjct: 80 ISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYA 139
Query: 118 TGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173
TG+ GKWHLG+ E A P H GF F G+P+S G C + +
Sbjct: 140 TGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-MGDCARWELSEKRVNLEQKLN 198
Query: 174 -----QGLVPIPLLANLSVEAQP-PWLPG----------LEARYMAFAHDLMADA----- 212
LV + L+A P W+P L + Y A + AD
Sbjct: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
Query: 213 --------------------------QRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246
+ + PF L+ + H H P + ++F +S G
Sbjct: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
Query: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGK 302
+GD++ E+D VG ++ + GL TL+ FT+D+G + GG +G+ + GK
Sbjct: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
Query: 303 GT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLS 359
G +EGG+R P + WPG + G V E S +D+ PT+ LAG +P + +DG DL
Sbjct: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
Query: 360 PLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFT---QGSAHSDTTADPAC 414
PLLLGT + S + L Y + R R +K HF T Q C
Sbjct: 439 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVC 498
Query: 415 HA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 473
+ H+PPLL+DLS+DP E + L + P Q ++++Q + ++
Sbjct: 499 PCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFYQVMERVQQAVWEHQRTLSPV 555
Query: 474 PSQVARGED---PALQICCHP 491
P Q+ R + P LQ CC P
Sbjct: 556 PLQLDRLGNIWRPWLQPCCGP 576
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 219 bits (557), Expect = 6e-57
Identities = 175/543 (32%), Positives = 253/543 (46%), Gaps = 80/543 (14%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNIVLI DDLG GDLGCYG+ + TP++D+LA G+R T SLC+PSR+A LTGR
Sbjct: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
Query: 81 LPVRMGMYPG--------VLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
P+R GM + VP+ GLPL E T+A +L +GY TG+ GKWH G+ +
Sbjct: 90 YPIRSGMVSSGNRRVIQNLAVPA---GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDS 146
Query: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP-PATPCDGGCDQGL------VPIPLLA-- 183
H ++ G Y + +C+P P+ + + L V I +L
Sbjct: 147 RSDQCHHPYN--YGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLT 204
Query: 184 --NLSVEAQPPWLPGLEARYMAF----------------------AHDLMADAQRQDRP- 218
LS PWL F H++ + +R
Sbjct: 205 FGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAG 264
Query: 219 ------------------FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGT 260
F L+++ H H P + F S G +GD++ E+D+ VG
Sbjct: 265 SIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
Query: 261 LMTAIGDLGLLEETLVIFTADNGP--ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPAL 315
++ AI D GL TLV FT+D+G E R GG +G+ + GKG +EGG+R P +
Sbjct: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
Query: 316 AFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQS 372
WPG + G + E S +D+LPT+A+++G LP + +DG DL PLL G + S +
Sbjct: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEF 444
Query: 373 LFFY-PSYPDEVRGVFAVRTGK-YKAHFFT---QGSAHSDTTADPACHA-SSSLTAHEPP 426
LF Y SY VR + +G +KAH+ T Q A C +T H PP
Sbjct: 445 LFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPP 504
Query: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 486
LL+DLS+DP E+ L V++ + + VT+ S++ +G L+
Sbjct: 505 LLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGR-TWLK 563
Query: 487 ICC 489
CC
Sbjct: 564 PCC 566
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 152 bits (383), Expect = 9e-37
Identities = 146/491 (29%), Positives = 208/491 (42%), Gaps = 81/491 (16%)
Query: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
Query: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
L G + Y A A ++P FLY A H
Sbjct: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
Query: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
Query: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
Query: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPR----------------------------QSLF 374
A G LDGFD+ + SPR SL
Sbjct: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
Query: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPL----LYD 430
Y ++ V A+R G +K G + P+ + S + + +PP L+D
Sbjct: 421 EYSAFNTSVHA--AIRHGNWKLLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFD 476
Query: 431 LSKDPGENYNL 441
+ +DP E ++L
Sbjct: 477 IDRDPEERHDL 487
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 150 bits (379), Expect = 3e-36
Identities = 141/482 (29%), Positives = 205/482 (42%), Gaps = 76/482 (15%)
Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
A +PP+I+ I DD GY D+G +G T P LD+LAA G++ ++Y+ +CTPSR+
Sbjct: 42 APPQPPHIIFILTDDQGYHDVGYHGSDIET-PTLDRLAAKGVKLENYYIQ-PICTPSRSQ 99
Query: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135
LLTGR + G+ ++ P LPL++VT+ + L GY T M GKWHLG + L
Sbjct: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-L 158
Query: 136 PPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEA 189
P +GF FLG Y++D CDG G+ L +V
Sbjct: 159 PTRRGFDTFLGSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV-- 199
Query: 190 QPPWLPGLEARYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER---- 241
W GL +Y + A + RP FLY A H P S + + R
Sbjct: 200 --AW--GLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTM 255
Query: 242 --SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
R + + +D AV + A+ G +++IF++DNG +T GG + LR
Sbjct: 256 GNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLR 312
Query: 300 CGKGTTYEGGVREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFD 357
KGT +EGGVR P + L D PTL LAG LDG+D
Sbjct: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
Query: 358 LSPLLLGTGKSPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQG 402
+ P + SPR + P Y G A+R G++K T
Sbjct: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGD 430
Query: 403 SAHSD--------TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQ 454
+ D T + + + L+++S DP E +L AG P+V++
Sbjct: 431 PGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVR 486
Query: 455 AL 456
L
Sbjct: 487 TL 488
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 149 bits (377), Expect = 4e-36
Identities = 128/391 (32%), Positives = 175/391 (44%), Gaps = 45/391 (11%)
Query: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
Query: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
Query: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
L G + Y A A ++P FLY A H
Sbjct: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
Query: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
Query: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
Query: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPRQSL 373
A G LDGFD+ + SPR L
Sbjct: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIEL 391
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
Query: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
Query: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
Query: 468 AAVTFGPSQVARGE---DPALQICC 489
+ P Q + P LQ+CC
Sbjct: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
Score = 130 bits (328), Expect = 2e-30
Identities = 69/139 (49%), Positives = 89/139 (64%), Gaps = 9/139 (6%)
Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77
A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T LCTPSRAA +
Sbjct: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
Query: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129
TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+
Sbjct: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
Query: 130 -PEGAFLPPHQGFHRFLGI 147
+ P H GF+ F GI
Sbjct: 144 KTDFCHHPLHHGFNYFYGI 162
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 134 bits (337), Expect = 2e-31
Identities = 68/139 (48%), Positives = 87/139 (62%), Gaps = 10/139 (7%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNIVL+ ADDLG GDL CYG+ S +TPN+D+LA+ G+R T S+CTPSRAA LTGR
Sbjct: 7 PNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGR 66
Query: 81 LPVRMGMYPGVLVP------SSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----P 130
P+R GM + GGLP E T A++L RGY TG+ GKWHLG+
Sbjct: 67 YPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRN 126
Query: 131 EGAFLPPHQGFHRFLGIPY 149
+ + P + GFH F G+P+
Sbjct: 127 DHCYHPLNHGFHYFYGVPF 145
Score = 122 bits (307), Expect = 6e-28
Identities = 87/244 (35%), Positives = 126/244 (51%), Gaps = 13/244 (5%)
Query: 207 DLMADAQRQDR-PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAI 265
+ +A +R R PF L+++ H H P S + F RS G +GD++ E+D VG ++ A+
Sbjct: 248 EALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMVGKILDAL 307
Query: 266 GDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPG 320
L TLV FT+DNG P + GG +G+ + GKG +EGG+R P + WP
Sbjct: 308 DQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPS 367
Query: 321 HIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLG-TGKSPRQSLFFYP 377
+ G V +E S +D+ PTL+ + G L + +DG +L PLL G S + LF Y
Sbjct: 368 VLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLFHYC 427
Query: 378 S-YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTA---DPACHASSSLTAHEPPLLYDLSK 433
Y VR +KAH+ T T A C S +T H+PPLL+D+S+
Sbjct: 428 GVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDPPLLFDISR 487
Query: 434 DPGE 437
DP E
Sbjct: 488 DPSE 491
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 133 bits (334), Expect = 4e-31
Identities = 126/470 (26%), Positives = 203/470 (43%), Gaps = 52/470 (11%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
P+++ I ADD G+ D+G +G T P LD+LAA G++ ++YV +CTPSR+ +TG+
Sbjct: 76 PHLIFILADDQGFRDVGYHGSEIKT-PTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQG 140
+ G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +G
Sbjct: 134 YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRG 192
Query: 141 FHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA- 199
F F G G T + +P G C L + A + G+ +
Sbjct: 193 FDTFFGSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYST 239
Query: 200 -RYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLM 252
Y ++A + +P FLY A H P Q G+ F R + L
Sbjct: 240 QMYTQRVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLS 298
Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
LD A+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 299 CLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRA 355
Query: 313 PALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPR 370
P G V EL D PTL +LA + ++ LDG+D+ + +SPR
Sbjct: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
Query: 371 QSLF--FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC--- 414
+ P Y G +A G + T +SD +
Sbjct: 416 VDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNL 475
Query: 415 ------HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 476 GPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
Query: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
Query: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
+ P + GF F G+P++
Sbjct: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
Score = 112 bits (281), Expect = 6e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 277
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
Query: 278 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 331
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
Query: 332 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 389
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
Query: 390 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 437
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
Query: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
Query: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
+ P + GF F G+P++
Sbjct: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
Score = 32.3 bits (72), Expect = 1.0
Identities = 13/38 (34%), Positives = 22/38 (57%)
Query: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELD 255
PF L+ + H H P + +F +S G +GD++ E+D
Sbjct: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMD 330
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 99.0 bits (245), Expect = 9e-21
Identities = 146/569 (25%), Positives = 203/569 (35%), Gaps = 154/569 (27%)
Query: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + +
Sbjct: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64
Query: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
VS C+PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK
Sbjct: 65 TSVSSCSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123
Query: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183
H VGPE + Y+ + G + + + I LL
Sbjct: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159
Query: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238
++ Q DRPFFLY A H H PQ+ +F
Sbjct: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193
Query: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261
E+ G G G ++ +D VG +
Sbjct: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
Query: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321
+ + D G+L +TLVIFT+DNG G+ Y G EP L P H
Sbjct: 254 LQELRDAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEH 301
Query: 322 IA--PGVTHELASSLDLLPTLAALAGAPLPN--------VTLDGFDLSPLL--------L 363
V+ S LDL PT+ P P+ + L G L P L +
Sbjct: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATV 361
Query: 364 GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAH 423
+S + YP + R V +K F + T + + TA
Sbjct: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRT---TAG 418
Query: 424 EPP---------------LLYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQL 466
+P LYD S+DP E NL P Q L+ L QL K Q
Sbjct: 419 QPTGWYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQW 473
Query: 467 DAAVTFGPSQVARGEDPALQICCHPGCTP 495
+ T P A D L+ P C P
Sbjct: 474 E---THDPWVCA--PDGVLEEKLSPQCQP 497
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 72.0 bits (175), Expect = 1e-12
Identities = 103/399 (25%), Positives = 168/399 (42%), Gaps = 56/399 (14%)
Query: 3 APRSLLLALAAGLAV------ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG 56
+P LLL L L V R PN+VL+ DD LG T + ++ G
Sbjct: 23 SPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV-LGGMTPLKKTKALIGEM---G 78
Query: 57 LRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVP--SSRGGLPLEEVTV--AEVLA 112
+ F+ YVP +LC PSRA++LTG+ P + L SS+ ++E A + +
Sbjct: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRS 138
Query: 113 ARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDG-- 170
GY T AGK+ + GA P G + + +S+ +N + +G
Sbjct: 139 MCGYQTFFAGKY---LNEYGA---PDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKA 192
Query: 171 ---GCDQGLVPIP-LLANLSVEAQPPWLPGLEARYMAFA----HDLMADAQRQDRPFFLY 222
G + + + +LAN+S++ + E +M A H A + + F
Sbjct: 193 RKHGENYSVDYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
Query: 223 YASHHTHYP-QFSGQSFAERSGRGPFGDS---------------LMELDAAVGTLMTAIG 266
+A + ++ + + + R + P +S L+ +D V L+ +
Sbjct: 252 FAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311
Query: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV 326
G L T + +T+DNG T + S L K YE ++ P L PG I P
Sbjct: 312 FTGELNNTYIFYTSDNGYHTGQFS-------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQ 363
Query: 327 THE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364
T + L +++DL PT+ +AG L +DG L P+L G
Sbjct: 364 TSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRG 402
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
Query: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
Query: 373 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425
+P + E G + +RT +K ++ G A
Sbjct: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
Query: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
P L+DLS DP E L VA PE+ +L Q
Sbjct: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
Score = 35.0 bits (79), Expect = 0.16
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 12/109 (11%)
Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTT---PNLDQLAAGGLRFTDFYVPVSLCTPSRA 74
A+ PN+VL+ +D D HP S P ++ + G F + Y +C PSRA
Sbjct: 29 AKAPNVVLVVSDSF---DGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
Query: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
A+ +G + ++ GL T +V+ GY T GK
Sbjct: 86 AMWSGLFTHLTESW------NNFKGLDPNYTTWMDVMERHGYRTQKFGK 128
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 92/367 (25%), Positives = 150/367 (40%), Gaps = 45/367 (12%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++Q GG F + +V +C PSR+++LTG+
Sbjct: 44 PNIILVLTDDQDV-ELGSMQVMNKTRRIMEQ---GGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Y SS E T A L + GY T GK+ G+++PP
Sbjct: 100 YVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYN--GSYVPP-- 155
Query: 140 GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP-LLANLSV------EAQPP 192
G+ ++G+ + N T G D + L+ N SV + P
Sbjct: 156 GWKEWVGLLKN---SRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYP 212
Query: 193 WLPGLEARYMAFAHD----------LMADAQRQDRPFFLYYASHHTHY-PQFSG------ 235
P L A H L +A + P + Y + H+ +++G
Sbjct: 213 HRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIH 272
Query: 236 QSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCS 295
F R +LM +D ++ T+ + + G L+ T +++TAD+G G
Sbjct: 273 MEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQF 325
Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDG 355
GL++ GK YE +R P P A + + ++DL PT+ +AG +P +DG
Sbjct: 326 GLVK-GKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDG 383
Query: 356 FDLSPLL 362
+ LL
Sbjct: 384 KSILKLL 390
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 64.3 bits (155), Expect = 2e-10
Identities = 92/367 (25%), Positives = 150/367 (40%), Gaps = 45/367 (12%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++Q GG F + +V +C PSR+++LTG+
Sbjct: 44 PNIILVLTDDQDV-ELGSMQVMNKTRRIMEQ---GGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Y SS E T A L + GY T GK+ G+++PP
Sbjct: 100 YVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYN--GSYVPP-- 155
Query: 140 GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP-LLANLSV------EAQPP 192
G+ ++G+ + N T G D + L+ N SV + P
Sbjct: 156 GWKEWVGLLKN---SRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYP 212
Query: 193 WLPGLEARYMAFAHD----------LMADAQRQDRPFFLYYASHHTHY-PQFSG------ 235
P L A H L +A + P + Y + H+ +++G
Sbjct: 213 HRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIH 272
Query: 236 QSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCS 295
F R +LM +D ++ T+ + + G L+ T +++TAD+G G
Sbjct: 273 MEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQF 325
Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDG 355
GL++ GK YE +R P P A + + ++DL PT+ +AG +P +DG
Sbjct: 326 GLVK-GKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDG 383
Query: 356 FDLSPLL 362
+ LL
Sbjct: 384 KSILKLL 390
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 92/367 (25%), Positives = 150/367 (40%), Gaps = 45/367 (12%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++Q GG F + +V +C PSR+++LTG+
Sbjct: 44 PNIILVLTDDQDV-ELGSMQVMNKTRRIMEQ---GGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Y SS E T A L + GY T GK+ G+++PP
Sbjct: 100 YVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYN--GSYVPP-- 155
Query: 140 GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP-LLANLSV------EAQPP 192
G+ ++G+ + N T G D + L+ N SV + P
Sbjct: 156 GWKEWVGLLKN---SRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYP 212
Query: 193 WLPGLEARYMAFAHD----------LMADAQRQDRPFFLYYASHHTHY-PQFSG------ 235
P L A H L +A + P + Y + H+ +++G
Sbjct: 213 HRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIH 272
Query: 236 QSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCS 295
F R +LM +D ++ T+ + + G L+ T +++TAD+G G
Sbjct: 273 MEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQF 325
Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDG 355
GL++ GK YE +R P P A + + ++DL PT+ +AG +P +DG
Sbjct: 326 GLVK-GKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDG 383
Query: 356 FDLSPLL 362
+ LL
Sbjct: 384 KSILKLL 390
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
Query: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
+ A L+ + PFFL H H P
Sbjct: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
Score = 35.4 bits (80), Expect = 0.12
Identities = 17/44 (38%), Positives = 27/44 (61%)
Query: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG 283
+R R + S+ LD VG L++A+ DL L T++ FT+D+G
Sbjct: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
Query: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
+ A L+ + PFFL H H P
Sbjct: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
Score = 38.9 bits (89), Expect = 0.011
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
Query: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334
K + ++ P + + PG A PG + +L +
Sbjct: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
Query: 335 DLLPTLAALAGAPLP 349
L PTLA LAG +P
Sbjct: 405 SLFPTLAGLAGLQVP 419
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 46.6 bits (109), Expect = 5e-05
Identities = 32/100 (32%), Positives = 45/100 (45%), Gaps = 9/100 (9%)
Query: 47 PNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVT 106
PN+DQLA+ L F + + ++C PSR + LTGR P +Y G T
Sbjct: 25 PNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAG---NFST 81
Query: 107 VAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQGFHRFL 145
+ + GY+T GK +H G P P GF F+
Sbjct: 82 IPQYFKENGYVTMSVGKVFHPGTAPR-----PESGFSWFV 116
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 7e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
Query: 140 GFHRFLGI 147
G+ +LG+
Sbjct: 155 GWREWLGL 162
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 7e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
Query: 140 GFHRFLGI 147
G+ +LG+
Sbjct: 155 GWREWLGL 162
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 7e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
Query: 140 GFHRFLGI 147
G+ +LG+
Sbjct: 155 GWREWLGL 162
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 7e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
Query: 140 GFHRFLGI 147
G+ +LG+
Sbjct: 155 GWREWLGL 162
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,049,579
Number of Sequences: 37866
Number of extensions: 1199064
Number of successful extensions: 3021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2899
Number of HSP's gapped (non-prelim): 67
length of query: 507
length of database: 18,247,518
effective HSP length: 107
effective length of query: 400
effective length of database: 14,195,856
effective search space: 5678342400
effective search space used: 5678342400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.