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Search of human proteins with 8923763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923763 centaurin-alpha 2 protein [Homo sapiens]
(381 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923763 centaurin-alpha 2 protein [Homo sapiens] 791 0.0
gi|6806913 centaurin, alpha 1 [Homo sapiens] 464 e-131
gi|23943872 small ArfGAP2 [Homo sapiens] 94 2e-19
gi|21264558 stromal membrane-associated GTPase-activating protei... 94 2e-19
gi|113204622 stromal membrane-associated GTPase-activating prote... 93 3e-19
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 88 1e-17
gi|7661880 centaurin beta1 [Homo sapiens] 86 6e-17
gi|187608516 centaurin, beta 2 [Homo sapiens] 84 2e-16
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 83 4e-16
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 82 6e-16
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 82 6e-16
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 80 4e-15
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 80 4e-15
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 79 7e-15
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 79 7e-15
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 78 1e-14
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 78 1e-14
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 77 2e-14
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 77 3e-14
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 76 4e-14
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 76 6e-14
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 74 2e-13
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 70 4e-12
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 70 4e-12
gi|46094081 development and differentiation enhancing factor 1 [... 65 8e-11
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 64 2e-10
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 64 3e-10
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 64 3e-10
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 63 5e-10
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 63 5e-10
>gi|8923763 centaurin-alpha 2 protein [Homo sapiens]
Length = 381
Score = 791 bits (2042), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 1 MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISR 60
MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISR
Sbjct: 1 MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISR 60
Query: 61 VKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERR 120
VKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERR
Sbjct: 61 VKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERR 120
Query: 121 EFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISI 180
EFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISI
Sbjct: 121 EFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISI 180
Query: 181 KDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAF 240
KDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAF
Sbjct: 181 KDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAF 240
Query: 241 PELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQG 300
PELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQG
Sbjct: 241 PELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQG 300
Query: 301 QVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVL 360
QVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVL
Sbjct: 301 QVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVL 360
Query: 361 SSPLTPLNRLTASTESGRSSR 381
SSPLTPLNRLTASTESGRSSR
Sbjct: 361 SSPLTPLNRLTASTESGRSSR 381
>gi|6806913 centaurin, alpha 1 [Homo sapiens]
Length = 374
Score = 464 bits (1195), Expect = e-131
Identities = 212/363 (58%), Positives = 277/363 (76%), Gaps = 5/363 (1%)
Query: 5 ERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSV 64
+ ++ +LELL+ P GNA CADCGA DPDWASY LG+FICL+C G+HRN P +S+VKSV
Sbjct: 3 KERRRAVLELLQRP--GNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSV 60
Query: 65 RLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFM- 123
RLD W+++ VEFM +GN +A+FE++VP+FYY P +DC +L+EQWIRAKYER+EF+
Sbjct: 61 RLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIY 120
Query: 124 ADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDL 183
+ + G REGFLWKRGRDN QFL RKFVL REG LKYF + K PKAV+ I+ L
Sbjct: 121 PEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHL 180
Query: 184 NATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPEL 243
NATFQ KIGHPHGLQ+TY +D TRN+F+YHE GKEIVDWFNALRAAR YL++AFP
Sbjct: 181 NATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGA 240
Query: 244 PESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVF 303
+++LVP L+RNYLK+G+MEKTGPKQ E F+KRWF +D +RRL+Y+K+PLDAF +G+VF
Sbjct: 241 SDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMD--DRRLMYFKDPLDAFARGEVF 298
Query: 304 LGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSP 363
+G+KE GY P +G+ W G+TIVTP+R+F+ C +E +Q+EW+ + + + P
Sbjct: 299 IGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRP 358
Query: 364 LTP 366
+ P
Sbjct: 359 MLP 361
>gi|23943872 small ArfGAP2 [Homo sapiens]
Length = 429
Score = 94.4 bits (233), Expect = 2e-19
Identities = 54/144 (37%), Positives = 78/144 (54%), Gaps = 6/144 (4%)
Query: 3 DRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRV 61
D +R + L LL D N CADC + P WAS+ +G+FIC+ C G+HRN ISRV
Sbjct: 8 DVDRYQAVLANLLLEED--NKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRV 65
Query: 62 KSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERRE 121
KSV LD W ++ M GN + +EA +P + PQ + + E +IR KYE+++
Sbjct: 66 KSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAV---EGFIRDKYEKKK 122
Query: 122 FMADGETISLPGNREGFLWKRGRD 145
+M I+ + WKRG +
Sbjct: 123 YMDRSLDINAFRKEKDDKWKRGSE 146
>gi|21264558 stromal membrane-associated GTPase-activating protein 1
isoform B [Homo sapiens]
Length = 440
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/178 (35%), Positives = 95/178 (53%), Gaps = 11/178 (6%)
Query: 5 ERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKS 63
E+++ L +LLR D N +CADC A P WAS+ +G+FIC+ C G+HRN ISRVKS
Sbjct: 15 EQHQLILSKLLREED--NKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKS 72
Query: 64 VRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFM 123
V LD W ++ M GN + + +EA +P + PQ + + E +IR KYE++++
Sbjct: 73 VNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAV---EFFIRDKYEKKKYY 129
Query: 124 ADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIK 181
D I++ N+E K + + + L E L K K+Q PK S K
Sbjct: 130 -DKNAIAIT-NKEKEKKKEEKKREKEPEKPAKPLTAEKLQK---KDQQLEPKKSTSPK 182
>gi|113204622 stromal membrane-associated GTPase-activating protein
1 isoform A [Homo sapiens]
Length = 467
Score = 93.2 bits (230), Expect = 3e-19
Identities = 49/119 (41%), Positives = 73/119 (61%), Gaps = 6/119 (5%)
Query: 5 ERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKS 63
E+++ L +LLR D N +CADC A P WAS+ +G+FIC+ C G+HRN ISRVKS
Sbjct: 15 EQHQLILSKLLREED--NKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKS 72
Query: 64 VRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREF 122
V LD W ++ M GN + + +EA +P + PQ + + E +IR KYE++++
Sbjct: 73 VNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAV---EFFIRDKYEKKKY 128
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 87.8 bits (216), Expect = 1e-17
Identities = 44/113 (38%), Positives = 65/113 (57%), Gaps = 2/113 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+ C DC A +PDWAS LG +C+ C G+HR+ +SRV+S+ LD W ++ M
Sbjct: 673 GNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTA 732
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLP 132
GN + +E + Y P + C KE+WIRAKYE++ F+A + +P
Sbjct: 733 MGNALANSVWEGALGG-YSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVP 784
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 85.9 bits (211), Expect = 6e-17
Identities = 48/130 (36%), Positives = 68/130 (52%), Gaps = 8/130 (6%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNA C DC P+WAS LG+ +C+ C G+HR+ S+V+S+ LD W+ +V+ M
Sbjct: 416 GNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCE 475
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDC-LVLKEQWIRAKYERREFMADGETISLPGNREGF 138
GN+ + +EARV A C KE WI AKY ++F+ + + G R G
Sbjct: 476 LGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLT--KLPEIRGRRGG- 532
Query: 139 LWKRGRDNSQ 148
RGR Q
Sbjct: 533 ---RGRPRGQ 539
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 84.3 bits (207), Expect = 2e-16
Identities = 49/128 (38%), Positives = 70/128 (54%), Gaps = 4/128 (3%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNA C DCG ADP WAS LGI +C+ C G+HR+ S+V+S+ LD W+ +++ M
Sbjct: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISL--PGNREG 137
GN + +EA V KE +IRAKY R+F+ D +ISL P ++
Sbjct: 470 LGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFV-DKYSISLSPPEQQKK 528
Query: 138 FLWKRGRD 145
F+ K +
Sbjct: 529 FVSKSSEE 536
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 3/123 (2%)
Query: 4 RERNKKRLLELLRAPDT-GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRV 61
RER K L R GN+ C DCG DP WAS LG+ +C+ C G+HR+ S+V
Sbjct: 396 RERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKV 455
Query: 62 KSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVP-AFYYIPQANDCLVLKEQWIRAKYERR 120
+S+ LD W+ +++ M GN V +EA+ A P A+ KE WI+ KY +
Sbjct: 456 RSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEK 515
Query: 121 EFM 123
+F+
Sbjct: 516 KFL 518
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 82.4 bits (202), Expect = 6e-16
Identities = 41/105 (39%), Positives = 60/105 (57%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+HC DC +P+WAS LG +C+ C G+HRN +SRV+S+ LD W +++ M
Sbjct: 567 GNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSS 626
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P + KE+WIRAKYE++ F+A
Sbjct: 627 IGNELANSVWEESSQG-RTKPSVDSTREEKERWIRAKYEQKLFLA 670
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 82.4 bits (202), Expect = 6e-16
Identities = 41/105 (39%), Positives = 60/105 (57%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+HC DC +P+WAS LG +C+ C G+HRN +SRV+S+ LD W +++ M
Sbjct: 620 GNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSS 679
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P + KE+WIRAKYE++ F+A
Sbjct: 680 IGNELANSVWEESSQG-RTKPSVDSTREEKERWIRAKYEQKLFLA 723
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 79.7 bits (195), Expect = 4e-15
Identities = 41/105 (39%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+HR+F +SRV+S+ LD W + + M
Sbjct: 475 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSS 534
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE WIR+KYE + F+A
Sbjct: 535 IGNELANSIWEGSSQG-QTKPSIKSTREEKEWWIRSKYEEKLFLA 578
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 79.7 bits (195), Expect = 4e-15
Identities = 41/105 (39%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+HR+F +SRV+S+ LD W + + M
Sbjct: 475 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSS 534
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE WIR+KYE + F+A
Sbjct: 535 IGNELANSIWEGSSQG-QTKPSIKSTREEKEWWIRSKYEEKLFLA 578
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 79.0 bits (193), Expect = 7e-15
Identities = 46/121 (38%), Positives = 62/121 (51%), Gaps = 4/121 (3%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+ C DCGA +P WAS LG IC+ C G+HRN +SRV+S+ LD W + +
Sbjct: 942 GNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTA 1001
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPGNREGFL 139
GN +E+ P + +E WIRAKYE+ F+A T P R+ L
Sbjct: 1002 IGNDTANRVWESDTRG-RAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ--L 1058
Query: 140 W 140
W
Sbjct: 1059 W 1059
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 79.0 bits (193), Expect = 7e-15
Identities = 46/121 (38%), Positives = 62/121 (51%), Gaps = 4/121 (3%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+ C DCGA +P WAS LG IC+ C G+HRN +SRV+S+ LD W + +
Sbjct: 586 GNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTA 645
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPGNREGFL 139
GN +E+ P + +E WIRAKYE+ F+A T P R+ L
Sbjct: 646 IGNDTANRVWESDTRG-RAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ--L 702
Query: 140 W 140
W
Sbjct: 703 W 703
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 78.2 bits (191), Expect = 1e-14
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+HR+ +SRV+S+ LD W + + M
Sbjct: 452 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 511
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE+WIR+KYE + F+A
Sbjct: 512 IGNDLANSIWEGSSQG-QTKPSEKSTREEKERWIRSKYEEKLFLA 555
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 78.2 bits (191), Expect = 1e-14
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+HR+ P +SRV+S+ LD W + + M
Sbjct: 475 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSS 534
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
N + +E P KE+WIR+KYE + F+A
Sbjct: 535 IVNDLANSIWEGSSQG-QTKPSEKSTREEKERWIRSKYEEKLFLA 578
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 77.4 bits (189), Expect = 2e-14
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+HR+ +SRV+S+ LD W + + M
Sbjct: 452 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 511
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE+WIR+KYE + F+A
Sbjct: 512 IGNDLANSIWEGSSQG-RTKPTEKSTREEKERWIRSKYEEKLFLA 555
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 77.0 bits (188), Expect = 3e-14
Identities = 39/105 (37%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+HC DC +P WAS LG+ +C+ C G+HR+ +SRV+S+ LD W + + M
Sbjct: 339 GNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 398
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE+WIR+KYE + F+A
Sbjct: 399 IGNDLANSIWEGSSQG-QTKPSIESTREEKERWIRSKYEHKLFLA 442
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 76.3 bits (186), Expect = 4e-14
Identities = 39/105 (37%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC DC +P WAS LG+ +C+ C G+H + +SRV+S+ LD W + + M
Sbjct: 452 GNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSS 511
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE+WIR+KYE + F+A
Sbjct: 512 IGNDLANSIWEGSSQG-QTKPSEKSTREEKERWIRSKYEEKLFLA 555
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 75.9 bits (185), Expect = 6e-14
Identities = 75/311 (24%), Positives = 126/311 (40%), Gaps = 54/311 (17%)
Query: 22 NAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLD--FWDDSIVEFMI 78
N CADCGA PDWAS L + IC C G HR +S+V+S+++D W ++++E +
Sbjct: 302 NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALC 361
Query: 79 HNGNLRVKAKFE------ARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLP 132
A+ + A + F P+A L L EQ + + EF+ + T +P
Sbjct: 362 AAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQ--AGQTLQMEFLRNNRTTEVP 419
Query: 133 G------------------NREGFLWKRG---------RDNSQFLRRKFVLLAREGLLKY 165
+ GFL+K R +F RR VL +G+L Y
Sbjct: 420 RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVL--GDGVLSY 477
Query: 166 FTKEQGKSPKAVISIKDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYH-ESGKEIVDW 224
F E+ +P I ++ HG + T+ L+++ ES ++ +W
Sbjct: 478 FENERAVTPNGEIRASEIVCLAVPPP--DTHGFEHTFEVYTEGERLYLFGLESAEQAHEW 535
Query: 225 FNALRAARLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHE 284
+ K P L E L R++ + G + + ++ WF+L E
Sbjct: 536 VKCI-------AKAFVPPLAED----LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSE 584
Query: 285 RRLLYYKNPLD 295
R ++ + P +
Sbjct: 585 LRAVFPEGPCE 595
Score = 34.3 bits (77), Expect = 0.19
Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 27/240 (11%)
Query: 126 GETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNA 185
G T P + G+L K S ++++V L + L +YF + K IS+ ++
Sbjct: 76 GSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHL-RYFDSNKDAYSKRFISVACIS- 133
Query: 186 TFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPE 245
IG IT + R ES E +W AL+ A + + A L
Sbjct: 134 --HVAAIGDQKFEVIT-----NNRTFAFRAESDVERKEWMQALQQAMAE--QRARARLSS 184
Query: 246 SELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLG 305
+ L+ ++ G + FK + + ++ LY KN E+ + +G
Sbjct: 185 AYLLGVPGSEQ-----PDRAGSLELRGFKNKLYVAVVGDKVQLY-KN----LEEYHLGIG 234
Query: 306 NKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLT 365
+ D+ G + + TP R F + SE E+++WLE+++G ++ L+
Sbjct: 235 I------TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS 288
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 74.3 bits (181), Expect = 2e-13
Identities = 39/105 (37%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GNAHC D +P WAS LG+ +C+ C G+HR+ +SRV+S+ LD W + + M
Sbjct: 475 GNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 534
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMA 124
GN + +E P KE+WIR+KYE + F+A
Sbjct: 535 IGNDLANSIWEGSSQG-QTKPSVKSTREEKERWIRSKYEEKLFLA 578
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 69.7 bits (169), Expect = 4e-12
Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+ C DCGAADP W S LG+ C+ C GVHR SR++S+ LD S + ++
Sbjct: 428 GNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALN 487
Query: 80 NGNLRVKAKFEARVPAF-YYIPQANDCLVLKEQWIRAKYERREF 122
GN EA++P+ P A + + +I AKY F
Sbjct: 488 MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF 531
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 69.7 bits (169), Expect = 4e-12
Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN+ C DCGAADP W S LG+ C+ C GVHR SR++S+ LD S + ++
Sbjct: 437 GNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALN 496
Query: 80 NGNLRVKAKFEARVPAF-YYIPQANDCLVLKEQWIRAKYERREF 122
GN EA++P+ P A + + +I AKY F
Sbjct: 497 MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF 540
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 65.5 bits (158), Expect = 8e-11
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 1/103 (0%)
Query: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFMIH 79
GN C DCG+++P W S LGI C+ C G+HR ISR++S+ LD S + +
Sbjct: 450 GNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKN 509
Query: 80 NGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREF 122
GN EA +P+ P + + +++++I AKY F
Sbjct: 510 VGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRF 552
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
3 [Homo sapiens]
Length = 1544
Score = 63.9 bits (154), Expect = 2e-10
Identities = 32/76 (42%), Positives = 44/76 (57%), Gaps = 3/76 (3%)
Query: 22 NAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLD--FWDDSIVEFMI 78
N CADCG++ PDWA+ LG+ IC C G HR IS+V+S++LD W + IV+ I
Sbjct: 501 NRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFI 560
Query: 79 HNGNLRVKAKFEARVP 94
GN R + +P
Sbjct: 561 VLGNDRANRFWAGTLP 576
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 63.5 bits (153), Expect = 3e-10
Identities = 41/121 (33%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 4 RERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVK 62
+E K+ + E+ R TGN C DCGA DP W S LGI C+ C G+HR SR++
Sbjct: 417 QELTKEIISEVQRM--TGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQ 474
Query: 63 SVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYI-PQANDCLVLKEQWIRAKYERRE 121
S+ LD S + + GN E +PA + P + ++ +I AKY R
Sbjct: 475 SLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERR 534
Query: 122 F 122
+
Sbjct: 535 Y 535
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 63.5 bits (153), Expect = 3e-10
Identities = 41/121 (33%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 4 RERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVK 62
+E K+ + E+ R TGN C DCGA DP W S LGI C+ C G+HR SR++
Sbjct: 417 QELTKEIISEVQRM--TGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQ 474
Query: 63 SVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYI-PQANDCLVLKEQWIRAKYERRE 121
S+ LD S + + GN E +PA + P + ++ +I AKY R
Sbjct: 475 SLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERR 534
Query: 122 F 122
+
Sbjct: 535 Y 535
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 62.8 bits (151), Expect = 5e-10
Identities = 30/76 (39%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 22 NAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLD--FWDDSIVEFMI 78
N CADCGA PDWAS L + IC C G HR +S+V+S+++D W ++++E +
Sbjct: 302 NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFL 361
Query: 79 HNGNLRVKAKFEARVP 94
GN + A VP
Sbjct: 362 QLGNGAGNRFWAANVP 377
Score = 34.3 bits (77), Expect = 0.19
Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 27/240 (11%)
Query: 126 GETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNA 185
G T P + G+L K S ++++V L + L +YF + K IS+ ++
Sbjct: 76 GSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHL-RYFDSNKDAYSKRFISVACIS- 133
Query: 186 TFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPE 245
IG IT + R ES E +W AL+ A + + A L
Sbjct: 134 --HVAAIGDQKFEVIT-----NNRTFAFRAESDVERKEWMQALQQAMAE--QRARARLSS 184
Query: 246 SELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLG 305
+ L+ ++ G + FK + + ++ LY KN E+ + +G
Sbjct: 185 AYLLGVPGSEQ-----PDRAGSLELRGFKNKLYVAVVGDKVQLY-KN----LEEYHLGIG 234
Query: 306 NKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLT 365
+ D+ G + + TP R F + SE E+++WLE+++G ++ L+
Sbjct: 235 I------TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS 288
Score = 33.5 bits (75), Expect = 0.33
Identities = 49/233 (21%), Positives = 86/233 (36%), Gaps = 45/233 (19%)
Query: 91 ARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPG----------------- 133
A + F P+A L L EQ + + EF+ + T +P
Sbjct: 441 AGINCFSGDPEAPTPLALAEQ--AGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 498
Query: 134 -NREGFLWKRG---------RDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDL 183
+ GFL+K R +F RR VL +G+L YF E+ +P I ++
Sbjct: 499 VSHSGFLYKTASAGKLLQDRRAREEFSRRWCVL--GDGVLSYFENERAVTPNGEIRASEI 556
Query: 184 NATFQTEKIGHPHGLQITYRRDGHTRNLFVYH-ESGKEIVDWFNALRAARLQYLKMAFPE 242
HG + T+ L+++ ES ++ +W + K P
Sbjct: 557 VCLAVPPP--DTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI-------AKAFVPP 607
Query: 243 LPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLD 295
L E L R++ + G + + ++ WF+L E R ++ + P +
Sbjct: 608 LAED----LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE 656
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 62.8 bits (151), Expect = 5e-10
Identities = 30/76 (39%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 22 NAHCADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLD--FWDDSIVEFMI 78
N CADCGA PDWAS L + IC C G HR +S+V+S+++D W ++++E +
Sbjct: 547 NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFL 606
Query: 79 HNGNLRVKAKFEARVP 94
GN + A VP
Sbjct: 607 QLGNGAGNRFWAANVP 622
Score = 34.3 bits (77), Expect = 0.19
Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 27/240 (11%)
Query: 126 GETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNA 185
G T P + G+L K S ++++V L + L +YF + K IS+ ++
Sbjct: 321 GSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHL-RYFDSNKDAYSKRFISVACIS- 378
Query: 186 TFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPE 245
IG IT + R ES E +W AL+ A + + A L
Sbjct: 379 --HVAAIGDQKFEVIT-----NNRTFAFRAESDVERKEWMQALQQAMAE--QRARARLSS 429
Query: 246 SELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLG 305
+ L+ ++ G + FK + + ++ LY KN E+ + +G
Sbjct: 430 AYLLGVPGSEQ-----PDRAGSLELRGFKNKLYVAVVGDKVQLY-KN----LEEYHLGIG 479
Query: 306 NKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLT 365
+ D+ G + + TP R F + SE E+++WLE+++G ++ L+
Sbjct: 480 I------TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS 533
Score = 33.5 bits (75), Expect = 0.33
Identities = 49/233 (21%), Positives = 86/233 (36%), Gaps = 45/233 (19%)
Query: 91 ARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPG----------------- 133
A + F P+A L L EQ + + EF+ + T +P
Sbjct: 686 AGINCFSGDPEAPTPLALAEQ--AGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 743
Query: 134 -NREGFLWKRG---------RDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDL 183
+ GFL+K R +F RR VL +G+L YF E+ +P I ++
Sbjct: 744 VSHSGFLYKTASAGKLLQDRRAREEFSRRWCVL--GDGVLSYFENERAVTPNGEIRASEI 801
Query: 184 NATFQTEKIGHPHGLQITYRRDGHTRNLFVYH-ESGKEIVDWFNALRAARLQYLKMAFPE 242
HG + T+ L+++ ES ++ +W + K P
Sbjct: 802 VCLAVPPP--DTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI-------AKAFVPP 852
Query: 243 LPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLD 295
L E L R++ + G + + ++ WF+L E R ++ + P +
Sbjct: 853 LAED----LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE 901
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,373,858
Number of Sequences: 37866
Number of extensions: 701616
Number of successful extensions: 1577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 1425
Number of HSP's gapped (non-prelim): 155
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.