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Search of human proteins with 14150114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
(315 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 652 0.0
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 652 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 156 3e-38
gi|16554627 WD repeat domain 5 [Homo sapiens] 156 3e-38
gi|23199987 WD repeat domain 5B [Homo sapiens] 154 1e-37
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 108 8e-24
gi|32189425 WD repeat domain 69 [Homo sapiens] 105 7e-23
gi|21071067 TBP-associated factor 5 [Homo sapiens] 99 6e-21
gi|113865883 WD repeat domain 38 [Homo sapiens] 94 2e-19
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 93 3e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 93 3e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 93 3e-19
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 92 8e-19
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 90 2e-18
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 90 2e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 4e-18
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 6e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 86 6e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 86 6e-17
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 85 7e-17
gi|26665869 WD repeat domain 51B [Homo sapiens] 85 7e-17
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 84 2e-16
gi|157266266 WD repeat domain 86 [Homo sapiens] 83 4e-16
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 82 8e-16
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 81 1e-15
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 81 1e-15
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 80 2e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 80 2e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 80 2e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 80 2e-15
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 652 bits (1682), Expect = 0.0
Identities = 315/315 (100%), Positives = 315/315 (100%)
Query: 1 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL 60
MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL
Sbjct: 1 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL 60
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE
Sbjct: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL
Sbjct: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
Query: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD
Sbjct: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
Query: 241 CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV 300
CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV
Sbjct: 241 CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV 300
Query: 301 QCWREEAYEAEDGAG 315
QCWREEAYEAEDGAG
Sbjct: 301 QCWREEAYEAEDGAG 315
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 652 bits (1682), Expect = 0.0
Identities = 315/315 (100%), Positives = 315/315 (100%)
Query: 1 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL 60
MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL
Sbjct: 1 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLL 60
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE
Sbjct: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL
Sbjct: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
Query: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD
Sbjct: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
Query: 241 CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV 300
CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV
Sbjct: 241 CCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSV 300
Query: 301 QCWREEAYEAEDGAG 315
QCWREEAYEAEDGAG
Sbjct: 301 QCWREEAYEAEDGAG 315
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 156 bits (394), Expect = 3e-38
Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)
Query: 5 EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63
+ KP P + P LK TL AV +V+F+ +G + + +DK +K+W G +T
Sbjct: 25 QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
Query: 64 SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123
SGH + D A S D++ L S DK + +WDV+SG+ ++ +GH+ V FN ++ +
Sbjct: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
Query: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181
I+SGS D S+R WD ++ + ++TL D VS+V + I++ S DG R +D
Sbjct: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
GQ + P++ FS +G+ L ++LD+TL+L D G+ L Y GHKN++Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296
+ S +VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 297 --GGSVQCWREE 306
+++ W+ +
Sbjct: 322 ENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 156 bits (394), Expect = 3e-38
Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)
Query: 5 EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63
+ KP P + P LK TL AV +V+F+ +G + + +DK +K+W G +T
Sbjct: 25 QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
Query: 64 SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123
SGH + D A S D++ L S DK + +WDV+SG+ ++ +GH+ V FN ++ +
Sbjct: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
Query: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181
I+SGS D S+R WD ++ + ++TL D VS+V + I++ S DG R +D
Sbjct: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
GQ + P++ FS +G+ L ++LD+TL+L D G+ L Y GHKN++Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296
+ S +VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 297 --GGSVQCWREE 306
+++ W+ +
Sbjct: 322 ENDKTIKLWKSD 333
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 154 bits (389), Expect = 1e-37
Identities = 100/292 (34%), Positives = 153/292 (52%), Gaps = 9/292 (3%)
Query: 11 PELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYE 69
PE P LK TL AV +V+F+ +G + + +D+ + +W G +T GH E
Sbjct: 26 PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85
Query: 70 VLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI 129
+ D A S D+S L S DK + LWDV SG+ ++ +GH+ V FN + +I+SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 130 DSSIRCWDCRSRRPEPVQTLDEARDGVSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFS 187
D +++ W+ ++ + ++TL D VS+V S I++GS DG R +D GQ
Sbjct: 146 DETVKIWEVKTGK--CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 188 DYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLS 244
V P++ FS +G+ L ++LD+TL+L D G L Y GHKN++Y + S
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
Query: 245 -ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
+VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
Score = 68.6 bits (166), Expect = 7e-12
Identities = 42/125 (33%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 18 LKTL-DCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS 76
LKTL D V V+F+ +G Y LT D TLKLW+ RG L+TY+GH E +
Sbjct: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN 261
Query: 77 FDNSS---LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI--DS 131
F + + SG D V +W++ + ++V+K +GH V + + +I S ++ D
Sbjct: 262 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321
Query: 132 SIRCW 136
+I+ W
Sbjct: 322 TIKLW 326
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 108 bits (269), Expect = 8e-24
Identities = 76/293 (25%), Positives = 138/293 (47%), Gaps = 15/293 (5%)
Query: 15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGT-LLRTYSGHGYEVLDA 73
Q + L +G V +F+ +G+ + G D+ + LWN T GH V++
Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
Query: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNT-VQFNEEATVILSGSIDSS 132
+ D S L S DK V +WD +G+ V++ +GH VN+ ++ +GS D +
Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
Query: 133 IRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDYV 190
++ WD R + +QT V +V +D +I++G +D ++ +DLR +L
Sbjct: 176 VKLWDIRKK--AAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
Query: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLD------KDTGELLGEYKGHKNQEYKLDCC 242
G +T S +G L +++D+T+R+ D K+ + + H ++ L C
Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292
Query: 243 LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
S + + + S D V+ WD + LP +G + +A+HP EP +++A
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Score = 60.5 bits (145), Expect = 2e-09
Identities = 32/115 (27%), Positives = 62/115 (53%), Gaps = 8/115 (6%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPL----RGTLLRTYSG--HGYE--VLDAAGSFD 78
+V + + +G+Y L+ D T+++W+ + ++ + G H +E +L + S D
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
Query: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
S + +G D+ V +WD S +++ K GHAG +N V F+ + +I+S S D +
Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 105 bits (261), Expect = 7e-23
Identities = 73/293 (24%), Positives = 133/293 (45%), Gaps = 6/293 (2%)
Query: 16 KRLKTLDCGQGAVRAVRFNVD-GNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAA 74
+ L TL+ + V A+ FN G+ T DKT KLW+ G T+ GH E++ +
Sbjct: 125 EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184
Query: 75 GSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIR 134
+ ++ + +G D LWD+ +G+ V RGH+ ++ ++ FN I++GS D ++
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 135 CWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--S 192
WD + R + A +S IL GS+D + +D G+ + G
Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304
Query: 193 PITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVS 252
I +CF G+ +S D T R+ T + + + +GH+ + K+ + + H+++
Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS--FNPQGNHLLT 362
Query: 253 CSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLT-AMGGSVQCWR 304
S D WD G L + + S A++ ++T + + + WR
Sbjct: 363 GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 103 bits (257), Expect = 2e-22
Identities = 76/271 (28%), Positives = 125/271 (46%), Gaps = 13/271 (4%)
Query: 31 VRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN---SSLCSGGG 87
V N G+ +T D+T KLW+ G L T GH V A +F+N + +G
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY--AIAFNNPYGDKIATGSF 155
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
DK LW V +G+ FRGH ++ + FN ++T++ +GS+D++ + WD ++ E V
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN--GEEVY 213
Query: 148 TL-DEARDGVS-SVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDG 203
TL + + +S S S I+ GS D V +D G+ + +G + I+ F+ D
Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC 273
Query: 204 QCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWD 263
L S+D T +L D G+ + GH ++ LD C + + S DG +
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYTGKLIATASADGTARIFS 331
Query: 264 LVEGALALALPVGSGVVQSLAYHPTEPCLLT 294
L G + ++++P LLT
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNHLLT 362
Score = 51.6 bits (122), Expect = 9e-07
Identities = 23/80 (28%), Positives = 41/80 (51%)
Query: 15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAA 74
+K + L+ +G + + FN GN+ LT SDKT ++W+ G L+ GH E+ A
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
Query: 75 GSFDNSSLCSGGGDKAVVLW 94
++ + + +G D +W
Sbjct: 395 FNYKGNIVITGSKDNTCRIW 414
Score = 37.7 bits (86), Expect = 0.013
Identities = 16/47 (34%), Positives = 25/47 (53%)
Query: 193 PITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKL 239
P+T ++ G C + S D T +L D +GE L +GH+N Y +
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 98.6 bits (244), Expect = 6e-21
Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 2/210 (0%)
Query: 12 ELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVL 71
E LK L G V F+ D NY L+ D T++LW+ T L Y GH Y V
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 72 DAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDS 131
D S SGG D+ LW Q +R F GH VN +F+ + + +GS D
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649
Query: 132 SIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG 191
++R WD + + T + + + + G+ DGRV +D+ G + + G
Sbjct: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 709
Query: 192 SPIT-CTC-FSRDGQCTLVSSLDSTLRLLD 219
T C+ FSRDG+ S+D+T+RL D
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 52.8 bits (125), Expect = 4e-07
Identities = 56/245 (22%), Positives = 87/245 (35%), Gaps = 43/245 (17%)
Query: 60 LRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNE 119
L+ GH V A+ S D + L S D V LW + + + ++GH V QF+
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 120 EATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYD 179
+SG D R W +P I AG +
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPL--------------------RIFAGHL-------- 627
Query: 180 LRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKL 239
+ + CT F + S D T+RL D G + + GHK + L
Sbjct: 628 ------------ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675
Query: 240 DCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLT-AMGG 298
S + + + DG+V WD+ G + L + V SL + L + +M
Sbjct: 676 --TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733
Query: 299 SVQCW 303
+V+ W
Sbjct: 734 TVRLW 738
Score = 39.7 bits (91), Expect = 0.004
Identities = 33/121 (27%), Positives = 59/121 (48%), Gaps = 9/121 (7%)
Query: 112 VNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSV 171
+ V +++++I G DS++R W S P+ ++++ +A D +S + ++L +
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVW---SVTPKKLRSVKQASD-LSLIDKESDDVLERIM 528
Query: 172 DGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKG 231
D + +L++ L+ P+ FS D L SS D T+RL T L YKG
Sbjct: 529 DEKTAS-ELKI--LYGH--SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG 583
Query: 232 H 232
H
Sbjct: 584 H 584
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 93.6 bits (231), Expect = 2e-19
Identities = 72/269 (26%), Positives = 105/269 (39%), Gaps = 40/269 (14%)
Query: 26 GAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSG 85
G V+ RF+ DG+ + D T++LW+ R LR GH V + S D+ L SG
Sbjct: 64 GPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 86 GGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEP 145
G DK V+LWDV SGQ++R GH + + F+ + +GS DS++ WD R P
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP-- 181
Query: 146 VQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQC 205
H+ L G + I+C C+S G
Sbjct: 182 ---------------AVSHQALEGH--------------------SANISCLCYSASG-L 205
Query: 206 TLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLV 265
S D T+ + T LL + KGH + S + + S V WD
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVT--WVKSIAFSPDELWLASAGYSRMVKVWDCN 263
Query: 266 EGALALALPVGSGVVQSLAYHPTEPCLLT 294
G L V + A+ P L++
Sbjct: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVS 292
Score = 54.7 bits (130), Expect = 1e-07
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
Query: 41 LTCGS-DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG 99
L GS DKT+ +W P +LL GH V A S D L S G + V +WD +G
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG 265
Query: 100 QVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQT 148
+ + +G +T F + +++SG+ D + R S+ P QT
Sbjct: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSPRDPQT 314
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/252 (26%), Positives = 111/252 (44%), Gaps = 9/252 (3%)
Query: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAG 75
K L+TL G V + + N ++ +D+TLK+WN G + T GH V
Sbjct: 294 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCM 349
Query: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
+ SG D + +WD+ +GQ + GH V VQ++ V SG+ D ++
Sbjct: 350 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV--SGAYDFMVKV 407
Query: 136 WDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPIT 195
WD + + TL + V S++ +++GS+D +R +D+ G G
Sbjct: 408 WDPETETC--LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 465
Query: 196 CTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
+ + + DST+++ D TG+ L +G N+ CL V++ S+
Sbjct: 466 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG-PNKHQSAVTCLQFNKNFVITSSD 524
Query: 256 DGKVFFWDLVEG 267
DG V WDL G
Sbjct: 525 DGTVKLWDLKTG 536
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 9/207 (4%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
+ GH V+ F + + SG D + +W +G+ +R GH G V + Q +
Sbjct: 256 KVLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 314
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
+I+SGS D +++ W+ + E + TL V + + + +++GS D +R +D+
Sbjct: 315 --IIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDI 370
Query: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
GQ +G C DG+ + + D +++ D +T L +GH N+ Y L
Sbjct: 371 ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430
Query: 241 CCLSERDTHVVSCSEDGKVFFWDLVEG 267
HVVS S D + WD+ G
Sbjct: 431 F----DGIHVVSGSLDTSIRVWDVETG 453
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/186 (29%), Positives = 94/186 (50%), Gaps = 13/186 (6%)
Query: 46 DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKF 105
D TL++W+ G L GH V +D + SG D V +WD + +
Sbjct: 362 DATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL 419
Query: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHE 165
+GH +V ++QF + ++SGS+D+SIR WD + + TL + S +++ D+
Sbjct: 420 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC--IHTLTGHQSLTSGMELKDNI 475
Query: 166 ILAGSVDGRVRRYDLRMGQLFSDYVG-----SPITCTCFSRDGQCTLVSSLDSTLRLLDK 220
+++G+ D V+ +D++ GQ G S +TC F+++ + SS D T++L D
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533
Query: 221 DTGELL 226
TGE +
Sbjct: 534 KTGEFI 539
Score = 75.1 bits (183), Expect = 8e-14
Identities = 43/165 (26%), Positives = 87/165 (52%), Gaps = 7/165 (4%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AVR V++ DG ++ D +K+W+P T L T GH V FD + SG
Sbjct: 385 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVSGS 440
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRP-EP 145
D ++ +WDV +G + GH + ++ + +++SG+ DS+++ WD ++ + +
Sbjct: 441 LDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT 498
Query: 146 VQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYV 190
+Q ++ + V+ ++ + + ++ S DG V+ +DL+ G+ + V
Sbjct: 499 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLV 543
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/252 (26%), Positives = 111/252 (44%), Gaps = 9/252 (3%)
Query: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAG 75
K L+TL G V + + N ++ +D+TLK+WN G + T GH V
Sbjct: 412 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCM 467
Query: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
+ SG D + +WD+ +GQ + GH V VQ++ V SG+ D ++
Sbjct: 468 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV--SGAYDFMVKV 525
Query: 136 WDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPIT 195
WD + + TL + V S++ +++GS+D +R +D+ G G
Sbjct: 526 WDPETETC--LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
Query: 196 CTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
+ + + DST+++ D TG+ L +G N+ CL V++ S+
Sbjct: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG-PNKHQSAVTCLQFNKNFVITSSD 642
Query: 256 DGKVFFWDLVEG 267
DG V WDL G
Sbjct: 643 DGTVKLWDLKTG 654
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 9/207 (4%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
+ GH V+ F + + SG D + +W +G+ +R GH G V + Q +
Sbjct: 374 KVLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 432
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
+I+SGS D +++ W+ + E + TL V + + + +++GS D +R +D+
Sbjct: 433 --IIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDI 488
Query: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
GQ +G C DG+ + + D +++ D +T L +GH N+ Y L
Sbjct: 489 ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
Query: 241 CCLSERDTHVVSCSEDGKVFFWDLVEG 267
HVVS S D + WD+ G
Sbjct: 549 F----DGIHVVSGSLDTSIRVWDVETG 571
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/186 (29%), Positives = 94/186 (50%), Gaps = 13/186 (6%)
Query: 46 DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKF 105
D TL++W+ G L GH V +D + SG D V +WD + +
Sbjct: 480 DATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL 537
Query: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHE 165
+GH +V ++QF + ++SGS+D+SIR WD + + TL + S +++ D+
Sbjct: 538 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC--IHTLTGHQSLTSGMELKDNI 593
Query: 166 ILAGSVDGRVRRYDLRMGQLFSDYVG-----SPITCTCFSRDGQCTLVSSLDSTLRLLDK 220
+++G+ D V+ +D++ GQ G S +TC F+++ + SS D T++L D
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Query: 221 DTGELL 226
TGE +
Sbjct: 652 KTGEFI 657
Score = 75.1 bits (183), Expect = 8e-14
Identities = 43/165 (26%), Positives = 87/165 (52%), Gaps = 7/165 (4%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AVR V++ DG ++ D +K+W+P T L T GH V FD + SG
Sbjct: 503 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVSGS 558
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRP-EP 145
D ++ +WDV +G + GH + ++ + +++SG+ DS+++ WD ++ + +
Sbjct: 559 LDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT 616
Query: 146 VQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYV 190
+Q ++ + V+ ++ + + ++ S DG V+ +DL+ G+ + V
Sbjct: 617 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLV 661
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/252 (26%), Positives = 111/252 (44%), Gaps = 9/252 (3%)
Query: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAG 75
K L+TL G V + + N ++ +D+TLK+WN G + T GH V
Sbjct: 332 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV--RCM 387
Query: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
+ SG D + +WD+ +GQ + GH V VQ++ V SG+ D ++
Sbjct: 388 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV--SGAYDFMVKV 445
Query: 136 WDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPIT 195
WD + + TL + V S++ +++GS+D +R +D+ G G
Sbjct: 446 WDPETETC--LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 503
Query: 196 CTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
+ + + DST+++ D TG+ L +G N+ CL V++ S+
Sbjct: 504 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG-PNKHQSAVTCLQFNKNFVITSSD 562
Query: 256 DGKVFFWDLVEG 267
DG V WDL G
Sbjct: 563 DGTVKLWDLKTG 574
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 9/207 (4%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
+ GH V+ F + + SG D + +W +G+ +R GH G V + Q +
Sbjct: 294 KVLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 352
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDL 180
+I+SGS D +++ W+ + E + TL V + + + +++GS D +R +D+
Sbjct: 353 --IIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDI 408
Query: 181 RMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLD 240
GQ +G C DG+ + + D +++ D +T L +GH N+ Y L
Sbjct: 409 ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468
Query: 241 CCLSERDTHVVSCSEDGKVFFWDLVEG 267
HVVS S D + WD+ G
Sbjct: 469 F----DGIHVVSGSLDTSIRVWDVETG 491
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/186 (29%), Positives = 94/186 (50%), Gaps = 13/186 (6%)
Query: 46 DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKF 105
D TL++W+ G L GH V +D + SG D V +WD + +
Sbjct: 400 DATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL 457
Query: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHE 165
+GH +V ++QF + ++SGS+D+SIR WD + + TL + S +++ D+
Sbjct: 458 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC--IHTLTGHQSLTSGMELKDNI 513
Query: 166 ILAGSVDGRVRRYDLRMGQLFSDYVG-----SPITCTCFSRDGQCTLVSSLDSTLRLLDK 220
+++G+ D V+ +D++ GQ G S +TC F+++ + SS D T++L D
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Query: 221 DTGELL 226
TGE +
Sbjct: 572 KTGEFI 577
Score = 75.1 bits (183), Expect = 8e-14
Identities = 43/165 (26%), Positives = 87/165 (52%), Gaps = 7/165 (4%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AVR V++ DG ++ D +K+W+P T L T GH V FD + SG
Sbjct: 423 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVSGS 478
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRP-EP 145
D ++ +WDV +G + GH + ++ + +++SG+ DS+++ WD ++ + +
Sbjct: 479 LDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT 536
Query: 146 VQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYV 190
+Q ++ + V+ ++ + + ++ S DG V+ +DL+ G+ + V
Sbjct: 537 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLV 581
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 91.7 bits (226), Expect = 8e-19
Identities = 42/113 (37%), Positives = 71/113 (62%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
V V+F+ + NY T +DKT++LW+ +G +R ++GH VL A S + L S G
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRS 140
D+ + LWD+ASG + ++ RGH + ++ F+ ++ +I S S+D+S+R WD R+
Sbjct: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 79.7 bits (195), Expect = 3e-15
Identities = 59/221 (26%), Positives = 99/221 (44%), Gaps = 17/221 (7%)
Query: 26 GAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSG 85
G V + RF D + L+C D +++ W+ T Y GH Y V D S + SG
Sbjct: 343 GPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASG 402
Query: 86 GGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEP 145
D+ LW +R + GH V+ V+F+ + + +GS D ++R W +++
Sbjct: 403 SHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS--AQQGNS 460
Query: 146 VQTLDEARDGVSSVKVSDH--EILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSR 201
V+ R V S+ S + + + D R++ +DL G L+ + G IT FS
Sbjct: 461 VRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP 520
Query: 202 DGQCTLVSSLDSTLRL-----------LDKDTGELLGEYKG 231
D +S+D+++R+ D + EL+G Y G
Sbjct: 521 DSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561
Score = 63.9 bits (154), Expect = 2e-10
Identities = 55/211 (26%), Positives = 86/211 (40%), Gaps = 6/211 (2%)
Query: 57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQ 116
GT ++ GH V D+S L S D ++ WD+ S ++GHA V +
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391
Query: 117 FNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVR 176
+ + SGS D + R W P + A + + + GS D VR
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451
Query: 177 RYDLRMG---QLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHK 233
+ + G +LF+ + G P+ FS +G+ + D L+L D +G L E +GH
Sbjct: 452 LWSAQQGNSVRLFTGHRG-PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510
Query: 234 NQEYKLDCCLSERDTHVVSCSEDGKVFFWDL 264
+ L S + S S D V WD+
Sbjct: 511 DNITSL--TFSPDSGLIASASMDNSVRVWDI 539
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/222 (26%), Positives = 89/222 (40%), Gaps = 25/222 (11%)
Query: 95 DVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRS--------RRPEPV 146
D +G ++ RGH G V + +F +++ +LS S D SIR WD S PV
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387
Query: 147 QTLDEARDGVSSVKVSDHEI--LAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRD 202
LD +S + + +GS D R + Y G + + C F +
Sbjct: 388 WDLD----------ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPN 437
Query: 203 GQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFW 262
S D T+RL G + + GH+ L S ++ S ED ++ W
Sbjct: 438 SNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGP--VLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 263 DLVEGALALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW 303
DL G L L + + SL + P + +A M SV+ W
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCS 84
+G V ++ F+ +G Y + G D+ LKLW+ GTL + GH + S D+ + S
Sbjct: 468 RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527
Query: 85 GGGDKAVVLWDV-----------ASGQVVRKFRGHAGKVNTVQFNEEATVILSG 127
D +V +WD+ +S ++V + G V +VQF ++++G
Sbjct: 528 ASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
Score = 30.8 bits (68), Expect = 1.6
Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 21/198 (10%)
Query: 112 VNTVQFNEEATVILSGSIDSSIRCWDCRSR--RPEPVQTLDEARDGVSS--VKVSDHEIL 167
+NT + + ++ ++ +G +S I+ W RS+ + EP Q +D +R ++ ++ D E
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQ-VDVSRIHLACDILEEEDDEDD 329
Query: 168 AGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLG 227
+ ++ R P+ T F D L S D ++R D +
Sbjct: 330 NAGTEMKILRGHC-----------GPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTV 378
Query: 228 EYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGS-GVVQSLAYH 286
Y+GH + LD +S + S S D W + L + G V + +H
Sbjct: 379 LYQGHAYPVWDLD--ISPYSLYFASGSHDRTARLWSF-DRTYPLRIYAGHLADVDCVKFH 435
Query: 287 PTEPCLLT-AMGGSVQCW 303
P L T + +V+ W
Sbjct: 436 PNSNYLATGSTDKTVRLW 453
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 90.1 bits (222), Expect = 2e-18
Identities = 60/183 (32%), Positives = 91/183 (49%), Gaps = 6/183 (3%)
Query: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVL--DAAGSFDNSSLCSGGGDKAVVLWDVAS 98
LT D T LW+ G LL+++ GHG +VL D A S ++ SGG DK ++WD+ S
Sbjct: 169 LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS 228
Query: 99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSS 158
GQ V+ F H +N+V++ SGS D++ R +D R+ R + + + G SS
Sbjct: 229 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 288
Query: 159 V--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDST 214
V +S + AG D + +D+ G S G + ++ S DG S D T
Sbjct: 289 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT 348
Query: 215 LRL 217
LR+
Sbjct: 349 LRV 351
Score = 65.1 bits (157), Expect = 8e-11
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 12/173 (6%)
Query: 73 AAGSFDNSSL--CSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF--NEEATVILSGS 128
+A SF NS + + GD LWDV SGQ+++ F GH V + +E +SG
Sbjct: 157 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 216
Query: 129 IDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHEILAGSVDGRVRRYDLRMGQLF 186
D WD RS + VQ + ++SV+ S +GS D R YDLR +
Sbjct: 217 CDKKAMVWDMRS--GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREV 274
Query: 187 SDYVGSPI----TCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQ 235
+ Y I + FS G+ D T+ + D G + GH+N+
Sbjct: 275 AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR 327
Score = 58.5 bits (140), Expect = 7e-09
Identities = 54/208 (25%), Positives = 83/208 (39%), Gaps = 20/208 (9%)
Query: 97 ASGQVVRKFR----GHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEA 152
A GQ V K R GH KV + + ++ I+S S D + WD + E T+
Sbjct: 47 ALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT 106
Query: 153 RDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQ------------LFSDYVGSPITCTCFS 200
+ S I G +D + Y L + + ++Y+ + C+ +
Sbjct: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSA---CSFTN 163
Query: 201 RDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVF 260
D Q L +S D T L D ++G+LL + GH LD SE VS D K
Sbjct: 164 SDMQI-LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAM 222
Query: 261 FWDLVEGALALALPVGSGVVQSLAYHPT 288
WD+ G A + S+ Y+P+
Sbjct: 223 VWDMRSGQCVQAFETHESDINSVRYYPS 250
Score = 47.4 bits (111), Expect = 2e-05
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 6/123 (4%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSF 77
++ + + + +VR+ G+ + D T +L++ + YS ++ A S
Sbjct: 232 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKES--IIFGASSV 289
Query: 78 DNSS----LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
D S L +G D + +WDV G V GH +V+T++ + + T SGS D ++
Sbjct: 290 DFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTL 349
Query: 134 RCW 136
R W
Sbjct: 350 RVW 352
Score = 40.0 bits (92), Expect = 0.003
Identities = 38/184 (20%), Positives = 64/184 (34%), Gaps = 10/184 (5%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
RT GHG +VL D + S D V++WD + V +
Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARD------GVSSVKVSDHEILAGSVDGR 174
I G +D+ + + E + ++ S SD +IL S DG
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
Query: 175 VRRYDLRMGQLFSDYVGSPITCTCF----SRDGQCTLVSSLDSTLRLLDKDTGELLGEYK 230
+D+ GQL + G C S G + D + D +G+ + ++
Sbjct: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
Query: 231 GHKN 234
H++
Sbjct: 237 THES 240
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 90.1 bits (222), Expect = 2e-18
Identities = 60/183 (32%), Positives = 91/183 (49%), Gaps = 6/183 (3%)
Query: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVL--DAAGSFDNSSLCSGGGDKAVVLWDVAS 98
LT D T LW+ G LL+++ GHG +VL D A S ++ SGG DK ++WD+ S
Sbjct: 211 LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS 270
Query: 99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSS 158
GQ V+ F H +N+V++ SGS D++ R +D R+ R + + + G SS
Sbjct: 271 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 330
Query: 159 V--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDST 214
V +S + AG D + +D+ G S G + ++ S DG S D T
Sbjct: 331 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT 390
Query: 215 LRL 217
LR+
Sbjct: 391 LRV 393
Score = 65.1 bits (157), Expect = 8e-11
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 12/173 (6%)
Query: 73 AAGSFDNSSL--CSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF--NEEATVILSGS 128
+A SF NS + + GD LWDV SGQ+++ F GH V + +E +SG
Sbjct: 199 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 258
Query: 129 IDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHEILAGSVDGRVRRYDLRMGQLF 186
D WD RS + VQ + ++SV+ S +GS D R YDLR +
Sbjct: 259 CDKKAMVWDMRS--GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREV 316
Query: 187 SDYVGSPI----TCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQ 235
+ Y I + FS G+ D T+ + D G + GH+N+
Sbjct: 317 AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR 369
Score = 58.5 bits (140), Expect = 7e-09
Identities = 54/208 (25%), Positives = 83/208 (39%), Gaps = 20/208 (9%)
Query: 97 ASGQVVRKFR----GHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEA 152
A GQ V K R GH KV + + ++ I+S S D + WD + E T+
Sbjct: 89 ALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT 148
Query: 153 RDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQ------------LFSDYVGSPITCTCFS 200
+ S I G +D + Y L + + ++Y+ + C+ +
Sbjct: 149 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSA---CSFTN 205
Query: 201 RDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVF 260
D Q L +S D T L D ++G+LL + GH LD SE VS D K
Sbjct: 206 SDMQI-LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAM 264
Query: 261 FWDLVEGALALALPVGSGVVQSLAYHPT 288
WD+ G A + S+ Y+P+
Sbjct: 265 VWDMRSGQCVQAFETHESDINSVRYYPS 292
Score = 47.4 bits (111), Expect = 2e-05
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 6/123 (4%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSF 77
++ + + + +VR+ G+ + D T +L++ + YS ++ A S
Sbjct: 274 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKES--IIFGASSV 331
Query: 78 DNSS----LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
D S L +G D + +WDV G V GH +V+T++ + + T SGS D ++
Sbjct: 332 DFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTL 391
Query: 134 RCW 136
R W
Sbjct: 392 RVW 394
Score = 40.0 bits (92), Expect = 0.003
Identities = 38/184 (20%), Positives = 64/184 (34%), Gaps = 10/184 (5%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
RT GHG +VL D + S D V++WD + V +
Sbjct: 99 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARD------GVSSVKVSDHEILAGSVDGR 174
I G +D+ + + E + ++ S SD +IL S DG
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
Query: 175 VRRYDLRMGQLFSDYVGSPITCTCF----SRDGQCTLVSSLDSTLRLLDKDTGELLGEYK 230
+D+ GQL + G C S G + D + D +G+ + ++
Sbjct: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
Query: 231 GHKN 234
H++
Sbjct: 279 THES 282
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 89.4 bits (220), Expect = 4e-18
Identities = 70/291 (24%), Positives = 122/291 (41%), Gaps = 33/291 (11%)
Query: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
+TL +V+ + F+ G +C +D T+KLW+ +RT GH + V A +
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Query: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW-- 136
+ S DK + +W+V +G V+ F GH V V+ N++ T+I S S D ++R W
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263
Query: 137 ---DCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSP 193
+C++ E + + +S S + ++ + ++ G P
Sbjct: 264 ATKECKAELREH----EHVVECISWAPESSYSSISEATGSETKK------------SGKP 307
Query: 194 ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSC 253
G L S D T+++ D TG L GH N + ++SC
Sbjct: 308 ---------GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN--WVRGVLFHSGGKFILSC 356
Query: 254 SEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLT-AMGGSVQCW 303
++D + WD L V SL +H T P ++T ++ +V+ W
Sbjct: 357 ADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 61.2 bits (147), Expect = 1e-09
Identities = 28/103 (27%), Positives = 52/103 (50%)
Query: 37 GNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV 96
G + L+ DKT+K+W+ G L T GH V + S DK + +WD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 97 ASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
+ + ++ H V ++ F++ A +++GS+D +++ W+CR
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 60.8 bits (146), Expect = 1e-09
Identities = 55/248 (22%), Positives = 102/248 (41%), Gaps = 26/248 (10%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSF 77
++T+ V +V +G++ ++ DKT+K+W G ++T++GH V +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 78 DNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
D + + S D+ V +W VA+ + + R H V + + E++ SI +
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSY---SSISEATGSET 301
Query: 138 CRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSP--IT 195
+S +P P +L+GS D ++ +D+ G VG +
Sbjct: 302 KKSGKPGPF-------------------LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
Query: 196 CTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSE 255
F G+ L + D TLR+ D + H++ LD + +VV+ S
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLD--FHKTAPYVVTGSV 400
Query: 256 DGKVFFWD 263
D V W+
Sbjct: 401 DQTVKVWE 408
Score = 33.5 bits (75), Expect = 0.25
Identities = 34/161 (21%), Positives = 55/161 (34%), Gaps = 42/161 (26%)
Query: 107 GHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEI 166
GH V V F+ +V++S S D++I+ WD + E +TL D V +
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDIS------ 157
Query: 167 LAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELL 226
F G+ S D T++L D E +
Sbjct: 158 --------------------------------FDHSGKLLASCSADMTIKLWDFQGFECI 185
Query: 227 GEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEG 267
GH + + + H+VS S D + W++ G
Sbjct: 186 RTMHGHDHNVSSV--AIMPNGDHIVSASRDKTIKMWEVQTG 224
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.5 bits (210), Expect = 6e-17
Identities = 58/179 (32%), Positives = 82/179 (45%), Gaps = 2/179 (1%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
VR+V F DG +T DKT+K+W R L + S H V A S D + S
Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 127
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
DK V LWD +S + V + H G V V F+ T I + +D++++ WD R+ R
Sbjct: 128 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 187
Query: 148 TLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQ 204
L A S S + ++ S D ++ DL G+L G P T FSR G+
Sbjct: 188 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 246
Score = 76.6 bits (187), Expect = 3e-14
Identities = 66/253 (26%), Positives = 102/253 (40%), Gaps = 8/253 (3%)
Query: 14 PQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA 73
PQ R + AV V F+ G+ + DKT+++W P + H V
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 71
Query: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
D S + DK V +W + + H V +F+ + +I+S S D ++
Sbjct: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131
Query: 134 RCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHEILAGSVDGRVRRYDLRMGQLFSDYV- 190
+ WD SR E V + E V+ V S I A +D V+ +D+R +L Y
Sbjct: 132 KLWDKSSR--ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 189
Query: 191 -GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH 249
+ + F G + +S DSTL++LD G LL Y H +Q S +
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEY 247
Query: 250 VVSCSEDGKVFFW 262
S D +V W
Sbjct: 248 FASGGSDEQVMVW 260
Score = 65.5 bits (158), Expect = 6e-11
Identities = 65/266 (24%), Positives = 107/266 (40%), Gaps = 13/266 (4%)
Query: 46 DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKF 105
D L +W+ + ++GH V S L SG DK V +W F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--D 163
R H V +V F + ++ S D +++ W + R + + +L + + V K S
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 164 HEILAGSVDGRVRRYDLRMGQLFSDYV--GSPITCTCFSRDGQCTLVSSLDSTLRLLDKD 221
I++ S D V+ +D + Y G +T F G C + +D+T+++ D
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 222 TGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQ 281
T LL Y+ H L ++++ S D + DL+EG L L G
Sbjct: 180 THRLLQHYQLHSAAVNGLS--FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 282 SLAYHPTEPCLLTAMGGS---VQCWR 304
++A+ T A GGS V W+
Sbjct: 238 TVAFSRTGEYF--ASGGSDEQVMVWK 261
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 85.5 bits (210), Expect = 6e-17
Identities = 58/179 (32%), Positives = 82/179 (45%), Gaps = 2/179 (1%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
VR+V F DG +T DKT+K+W R L + S H V A S D + S
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
DK V LWD +S + V + H G V V F+ T I + +D++++ WD R+ R
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 148 TLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQ 204
L A S S + ++ S D ++ DL G+L G P T FSR G+
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284
Score = 76.6 bits (187), Expect = 3e-14
Identities = 66/253 (26%), Positives = 102/253 (40%), Gaps = 8/253 (3%)
Query: 14 PQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA 73
PQ R + AV V F+ G+ + DKT+++W P + H V
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109
Query: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
D S + DK V +W + + H V +F+ + +I+S S D ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 134 RCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHEILAGSVDGRVRRYDLRMGQLFSDYV- 190
+ WD SR E V + E V+ V S I A +D V+ +D+R +L Y
Sbjct: 170 KLWDKSSR--ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 191 -GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH 249
+ + F G + +S DSTL++LD G LL Y H +Q S +
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEY 285
Query: 250 VVSCSEDGKVFFW 262
S D +V W
Sbjct: 286 FASGGSDEQVMVW 298
Score = 72.8 bits (177), Expect = 4e-13
Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 16/250 (6%)
Query: 58 TLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF 117
+L R + GH V S + L SG D +++W + +F GH V V F
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 118 NEEATVILSGSIDSSIRCWDCRSR--------RPEPVQTLDEARDGVSSVKVSDHEILAG 169
+ ++ SGS D ++R W + V+++ DG S V SD + +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 170 SVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEY 229
R +++ + Q + + C FS DG+ + +S D T++L DK + E + Y
Sbjct: 130 WATHR-QKFLFSLSQHI-----NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 230 KGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTE 289
H +D T + + D V WD+ L + S V L++HP+
Sbjct: 184 CEHGGFVTYVD--FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 290 PCLLTAMGGS 299
L+TA S
Sbjct: 242 NYLITASSDS 251
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/285 (24%), Positives = 115/285 (40%), Gaps = 13/285 (4%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AV V F+++ + D L +W+ + ++GH V S L SG
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPV 146
DK V +W FR H V +V F + ++ S D +++ W + R + +
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFL 138
Query: 147 QTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLRMGQLFSDYV--GSPITCTCFSRD 202
+L + + V K S I++ S D V+ +D + Y G +T F
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 198
Query: 203 GQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFW 262
G C + +D+T+++ D T LL Y+ H L ++++ S D +
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS--FHPSGNYLITASSDSTLKIL 256
Query: 263 DLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGS---VQCWR 304
DL+EG L L G ++A+ T A GGS V W+
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEYF--ASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 85.5 bits (210), Expect = 6e-17
Identities = 58/179 (32%), Positives = 82/179 (45%), Gaps = 2/179 (1%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
VR+V F DG +T DKT+K+W R L + S H V A S D + S
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
DK V LWD +S + V + H G V V F+ T I + +D++++ WD R+ R
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 148 TLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQ 204
L A S S + ++ S D ++ DL G+L G P T FSR G+
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 284
Score = 76.6 bits (187), Expect = 3e-14
Identities = 66/253 (26%), Positives = 102/253 (40%), Gaps = 8/253 (3%)
Query: 14 PQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA 73
PQ R + AV V F+ G+ + DKT+++W P + H V
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109
Query: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
D S + DK V +W + + H V +F+ + +I+S S D ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 134 RCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHEILAGSVDGRVRRYDLRMGQLFSDYV- 190
+ WD SR E V + E V+ V S I A +D V+ +D+R +L Y
Sbjct: 170 KLWDKSSR--ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 191 -GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH 249
+ + F G + +S DSTL++LD G LL Y H +Q S +
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPATTVAFSRTGEY 285
Query: 250 VVSCSEDGKVFFW 262
S D +V W
Sbjct: 286 FASGGSDEQVMVW 298
Score = 72.8 bits (177), Expect = 4e-13
Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 16/250 (6%)
Query: 58 TLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF 117
+L R + GH V S + L SG D +++W + +F GH V V F
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 118 NEEATVILSGSIDSSIRCWDCRSR--------RPEPVQTLDEARDGVSSVKVSDHEILAG 169
+ ++ SGS D ++R W + V+++ DG S V SD + +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 170 SVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEY 229
R +++ + Q + + C FS DG+ + +S D T++L DK + E + Y
Sbjct: 130 WATHR-QKFLFSLSQHI-----NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 230 KGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTE 289
H +D T + + D V WD+ L + S V L++HP+
Sbjct: 184 CEHGGFVTYVD--FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 290 PCLLTAMGGS 299
L+TA S
Sbjct: 242 NYLITASSDS 251
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/285 (24%), Positives = 115/285 (40%), Gaps = 13/285 (4%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AV V F+++ + D L +W+ + ++GH V S L SG
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPV 146
DK V +W FR H V +V F + ++ S D +++ W + R + +
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFL 138
Query: 147 QTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLRMGQLFSDYV--GSPITCTCFSRD 202
+L + + V K S I++ S D V+ +D + Y G +T F
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 198
Query: 203 GQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFW 262
G C + +D+T+++ D T LL Y+ H L ++++ S D +
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS--FHPSGNYLITASSDSTLKIL 256
Query: 263 DLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGS---VQCWR 304
DL+EG L L G ++A+ T A GGS V W+
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEYF--ASGGSDEQVMVWK 299
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 85.1 bits (209), Expect = 7e-17
Identities = 78/319 (24%), Positives = 149/319 (46%), Gaps = 32/319 (10%)
Query: 12 ELPQKRLKTLDCGQGA-VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTL---LRTYSGHG 67
+ P + + + GQ + V RF+ DG Y +T D +++WN G + L+ +
Sbjct: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
Query: 68 YEVLDAAG-----SFDNSSLCSGGGDKAVVLWDVASGQVVRKF-RGHAGKVNTVQFNEEA 121
+ ++D A S D L +G D + +W + SGQ +R+F R H+ V + F++++
Sbjct: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
Query: 122 TVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD-----HEILAGSVDGRVR 176
+ ILS S D +IR +S + TL E R S V + H I++ S DG V+
Sbjct: 320 SQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 374
Query: 177 RYDLRMGQLFSDY------VGSPITCTC---FSRDGQCTLVSSLDSTLRLLDKDTGELLG 227
++++ + + + G+ IT ++ + +V + +T+ +++ G+++
Sbjct: 375 IWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVR 433
Query: 228 EYKGHKNQEYKLDCC-LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYH 286
+ K + CC LS R + ED ++ + V G L L V V +A+H
Sbjct: 434 SFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493
Query: 287 PTEPCLLT-AMGGSVQCWR 304
P + + T + G ++ W+
Sbjct: 494 PHQNLIATYSEDGLLKLWK 512
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 85.1 bits (209), Expect = 7e-17
Identities = 60/217 (27%), Positives = 92/217 (42%), Gaps = 4/217 (1%)
Query: 13 LPQKRLKTLD--CGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEV 70
+P KR K + VR+V F+ DG + T DK++K+W+ R L + H + V
Sbjct: 88 IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWV 147
Query: 71 LDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSID 130
A S D + S DK + +WD + Q V F G N V FN T I S D
Sbjct: 148 RCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSD 207
Query: 131 SSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYV 190
+++ WD R + + S S + ++ S DG ++ DL G+L
Sbjct: 208 QTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQ 267
Query: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGEL 225
G P+ FS+ G+ D+ + L + EL
Sbjct: 268 GHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Score = 79.0 bits (193), Expect = 5e-15
Identities = 57/242 (23%), Positives = 101/242 (41%), Gaps = 14/242 (5%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
V +V+F+ GN + D+T++LW P + + H V S D L +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
DK++ +W + + + H V +F+ + +I+S S D +I+ WD ++ Q
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK-----Q 177
Query: 148 TLDEARDGVSSVKVSDHE-----ILAGSVDGRVRRYDLRMGQLFSDYV--GSPITCTCFS 200
++ D V D I + D V+ +D+R+ +L Y + C F
Sbjct: 178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
Query: 201 RDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVF 260
G + +S D TL++LD G L+ +GH + + S+ S D +V
Sbjct: 238 PSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS--FSKGGELFASGGADTQVL 295
Query: 261 FW 262
W
Sbjct: 296 LW 297
Score = 68.9 bits (167), Expect = 5e-12
Identities = 74/290 (25%), Positives = 121/290 (41%), Gaps = 19/290 (6%)
Query: 25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCS 84
+ A+ ++ + +G T D L LWN Y GH V S + L S
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLAS 77
Query: 85 GGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPE 144
D+ V LW +F+ H V +V F+ + + + S D SI+ W +R
Sbjct: 78 ASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF- 136
Query: 145 PVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYDLRMGQL---FSDYVGSPITCTCF 199
+ +L V K S I++ S D ++ +D Q FSD VG F
Sbjct: 137 -LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-NFVDF 194
Query: 200 SRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT--HVVSCSEDG 257
+ G C + D T+++ D +LL Y+ H C+S + ++++ S DG
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVN----CISFHPSGNYLITASSDG 250
Query: 258 KVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGS---VQCWR 304
+ DL+EG L L +G V ++++ ++ L A GG+ V WR
Sbjct: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSF--SKGGELFASGGADTQVLLWR 298
Score = 67.4 bits (163), Expect = 2e-11
Identities = 60/247 (24%), Positives = 105/247 (42%), Gaps = 20/247 (8%)
Query: 59 LLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFN 118
L R + GH + S + L + D ++LW+ ++ GH V +VQF+
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 119 EEATVILSGSIDSSIRCW--DCRSRRPE------PVQTLDEARDGVSSVKVSDHEILAGS 170
++ S S D ++R W D R + E PV+++D + DG + S
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG--------QFLATAS 121
Query: 171 VDGRVRRYDL-RMGQLFSDYVGSP-ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGE 228
D ++ + + R L+S Y + + C FS DG+ + S D T+++ D + +
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 229 YKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPT 288
+ +D + T + S D V WD+ L V SG V +++HP+
Sbjct: 182 FSDSVGFANFVD--FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
Query: 289 EPCLLTA 295
L+TA
Sbjct: 240 GNYLITA 246
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 83.6 bits (205), Expect = 2e-16
Identities = 58/233 (24%), Positives = 106/233 (45%), Gaps = 8/233 (3%)
Query: 75 GSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIR 134
G L +GG D V LW + + GH V +V+ N +I++GS SIR
Sbjct: 29 GKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIR 88
Query: 135 CWDCRSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYDLRMGQLFSDYVG- 191
WD + + ++TL + + S+ + + +GS D ++ +D+R Y G
Sbjct: 89 VWDLEAAK--ILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146
Query: 192 -SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHV 250
+ C FS DG+ ++ D T++L D G+++ E+ GH ++ + +
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE--FHPNEYLL 204
Query: 251 VSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSVQCW 303
S S D + FWDL + + + G V+S+ ++P CL + S++ +
Sbjct: 205 ASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVY 257
Score = 76.6 bits (187), Expect = 3e-14
Identities = 47/148 (31%), Positives = 72/148 (48%), Gaps = 8/148 (5%)
Query: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAG 75
K L+TL + + ++ F+ G + + D +KLW+ R + Y GH V
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
Query: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
S D L S D V LWD+ +G+++ +F GH G VN V+F+ ++ SGS D +IR
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 136 WD--------CRSRRPEPVQTLDEARDG 155
WD C P PV+++ DG
Sbjct: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Score = 65.9 bits (159), Expect = 5e-11
Identities = 45/192 (23%), Positives = 83/192 (43%), Gaps = 3/192 (1%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
V +VR N + ++++W+ +LRT GH + + SG
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 88 DKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQ 147
D + LWD+ V ++RGH+ V ++F+ + + S + D +++ WD + +
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 148 TLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQC 205
V +++ + +GS D +R +DL Q+ S G P+ F+ DG C
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG-C 244
Query: 206 TLVSSLDSTLRL 217
L S +LR+
Sbjct: 245 CLYSGCQDSLRV 256
Score = 65.5 bits (158), Expect = 6e-11
Identities = 50/242 (20%), Positives = 99/242 (40%), Gaps = 29/242 (11%)
Query: 37 GNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV 96
G T G D + LW+ + + + +GH V + + +G ++ +WD+
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 97 ASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSR--------RPEPVQT 148
+ +++R GH + ++ F+ + SGS D++I+ WD R + + V+
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 149 LDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCT 206
L + DG +D D V+ +DL G++ S++ G P+ F +
Sbjct: 153 LRFSPDGKWLASAAD--------DHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLL 204
Query: 207 LVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKL-----DCCLSERDTHVVSCSEDGKVFF 261
S D T+R D + +++ +G + CCL C + +V+
Sbjct: 205 ASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS------GCQDSLRVYG 258
Query: 262 WD 263
W+
Sbjct: 259 WE 260
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 82.8 bits (203), Expect = 4e-16
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 4/183 (2%)
Query: 37 GNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV 96
G +T +D T K+W G +T GH VL + +G D + WD+
Sbjct: 163 GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Query: 97 ASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGV 156
SG+ +R FR H G V ++ ++ SGS D +++CW + E V+T R V
Sbjct: 223 LSGEQLRVFREHRGSVICLELVNR--LVYSGSADRTVKCW--LADTGECVRTFTAHRRNV 278
Query: 157 SSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLR 216
S++K + GS D R +D + G+L + G C GQ +S D LR
Sbjct: 279 SALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALR 338
Query: 217 LLD 219
L D
Sbjct: 339 LWD 341
Score = 75.5 bits (184), Expect = 6e-14
Identities = 61/247 (24%), Positives = 101/247 (40%), Gaps = 20/247 (8%)
Query: 32 RFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS--FDNSS-------- 81
R V N + D+T ++W+ +G + R + GH VL A S +D S
Sbjct: 102 RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA 161
Query: 82 ----LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWD 137
L +G D +W VASG + RGH G V + + +GS D++IR WD
Sbjct: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Query: 138 CRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCT 197
S E ++ E R V +++ + + +GS D V+ + G+ + +
Sbjct: 222 ILSG--EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVS 279
Query: 198 CFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDG 257
S D+ R D +GEL ++GH + C+ + + S DG
Sbjct: 280 ALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHT----FIINCIQVHGQVLYTASHDG 335
Query: 258 KVFFWDL 264
+ WD+
Sbjct: 336 ALRLWDV 342
Score = 73.2 bits (178), Expect = 3e-13
Identities = 65/230 (28%), Positives = 100/230 (43%), Gaps = 29/230 (12%)
Query: 25 QGAVRAVRF-NVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLC 83
QG V F ++ TC +D T++ W+ L G L+ Y GH V + N+ L
Sbjct: 54 QGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLF 111
Query: 84 SGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFN-----------EEAT---VILSGSI 129
S D+ +W V GQ+ R+FRGH V T+ ++ EEA ++++GS
Sbjct: 112 SSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGST 171
Query: 130 DSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD---HEILAGSVDGRVRRYDLRMGQ-- 184
D + + W S QTL G V D H GS D +R +D+ G+
Sbjct: 172 DGTAKVWQVASGCCH--QTL-RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
Query: 185 -LFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHK 233
+F ++ GS I C + S D T++ DTGE + + H+
Sbjct: 229 RVFREHRGSVI---CLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHR 275
Score = 66.2 bits (160), Expect = 4e-11
Identities = 74/306 (24%), Positives = 115/306 (37%), Gaps = 32/306 (10%)
Query: 25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCS 84
+G + + + DG LT D T +LW+ G GH V + + CS
Sbjct: 15 RGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCS 74
Query: 85 GGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW-------- 136
D + WDV +GQ ++ +RGH VN + + S S D + R W
Sbjct: 75 --ADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMS 130
Query: 137 -DCRSRRPEPVQTLDEARDGVSSVKVSDHE-----ILAGSVDGRVRRYDLRMG---QLFS 187
+ R R + A + S ++ ++ GS DG + + + G Q
Sbjct: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
Query: 188 DYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERD 247
+ G+ + C G S D+T+R D +GE L ++ H+ CL +
Sbjct: 191 GHTGA-VLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV----ICLELVN 245
Query: 248 THVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSVQCWREEA 307
V S S D V W G V +L YH L T G + C R A
Sbjct: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDA--CAR--A 299
Query: 308 YEAEDG 313
++A+ G
Sbjct: 300 FDAQSG 305
Score = 58.5 bits (140), Expect = 7e-09
Identities = 50/190 (26%), Positives = 85/190 (44%), Gaps = 26/190 (13%)
Query: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
+TL GAV + + G+ T +D T++ W+ L G LR + H V+
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI--CLELV 244
Query: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDC 138
N + SG D+ V W +G+ VR F H V+ ++++ A + +GS D+ R +D
Sbjct: 245 NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDA 302
Query: 139 RS---RRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLR-------------- 181
+S RR T ++ ++V + S DG +R +D+R
Sbjct: 303 QSGELRRVFRGHTFI-----INCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRS 357
Query: 182 MGQLFSDYVG 191
+ +LFS+ VG
Sbjct: 358 LSRLFSNKVG 367
Score = 49.7 bits (117), Expect = 3e-06
Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 24/228 (10%)
Query: 57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQ 116
G+ LR + H + + S D L +G D LW A GQ +GH V Q
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
Query: 117 FNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVR 176
+EA + S D +IR WD + + +Q V+ + V+++++ + S D R
Sbjct: 65 LEDEAA--FTCSADCTIRRWDVLT--GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120
Query: 177 RYDLRMGQLFSDYVGS---------------PIT-CTCFSRDGQCTLVSSLDSTLRLLDK 220
+ + GQ+ ++ G P T C + G + S D T ++
Sbjct: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
Query: 221 DTGELLGEYKGHKNQEYKLDCCLSERDTHVV-SCSEDGKVFFWDLVEG 267
+G +GH + C + + H + S D + WD++ G
Sbjct: 181 ASGCCHQTLRGHTG---AVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 81.6 bits (200), Expect = 8e-16
Identities = 79/323 (24%), Positives = 142/323 (43%), Gaps = 24/323 (7%)
Query: 4 PEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63
P+P+ PP K + + G VR + + +T +D+T+K+W+ G L +
Sbjct: 186 PKPQWHPP---WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL 242
Query: 64 SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123
+GH V S + L S G DK V WD+ +V+R + GH V + + V
Sbjct: 243 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV 302
Query: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVK--VSDHEILAGSVDGRVRRYDLR 181
+++ S DS+ R WD R++ V TL + V++V+ ++ +I+ GS D +R +DL
Sbjct: 303 LVTCSRDSTARIWDVRTK--ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
Query: 182 MGQ---LFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
G+ +++ S R T S ++ G + GH
Sbjct: 361 AGKTRVTLTNHKKSVRAVVLHPR--HYTFASGSPDNIKQWKFPDGSFIQNLSGH---NAI 415
Query: 239 LDCCLSERDTHVVSCSEDGKVFFWDLVEG----ALALALPVGS----GVVQSLAYHPTEP 290
++ D +VS +++G + WD G + A+ GS + + A+ +E
Sbjct: 416 INTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSES 475
Query: 291 CLLTAMGG-SVQCWREEAYEAED 312
LLTA +++ +RE+ E+
Sbjct: 476 RLLTAEADKTIKVYREDDTATEE 498
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 80.9 bits (198), Expect = 1e-15
Identities = 82/313 (26%), Positives = 135/313 (43%), Gaps = 40/313 (12%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AV V F+ G+ T D +K+W+ G LL T GH E+ D A +++N+ + +G
Sbjct: 188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGS 247
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEA----TVILSGSIDSSIRC---WDCR 139
DK + +W + + V +GH G + ++QF+ A ++S D ++ C WD
Sbjct: 248 CDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTV-CFWQWDLE 306
Query: 140 SRR--PEPVQTLDEARDGV----SSVKVSDHEILAGSVDGRVRRYDL------RMGQLFS 187
S + P P++ ++ R GV SS V + GS D +R Y L ++ +L S
Sbjct: 307 SLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELES 366
Query: 188 DYVGSPITCTCFSRDGQCTLVSSLDSTLR------------LLDKDT---GELLGEYKGH 232
+ F +G L S D T R LLD T G+L E +
Sbjct: 367 H--TDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERF 424
Query: 233 KNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCL 292
+ + ++ D+ VV+ D + W+ G L L + V L HP + +
Sbjct: 425 MKPKVTM-IAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
Query: 293 LTAMG--GSVQCW 303
+ + G GS+ W
Sbjct: 484 MLSAGHDGSIFIW 496
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/220 (24%), Positives = 88/220 (40%), Gaps = 22/220 (10%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
R GH V A + +G D V +W +G+++ RGH+ +++ + N E
Sbjct: 180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE 239
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV------KVSDHEILAGSVDGR 174
T+I +GS D IR W R+ PV L ++S+ K S +++ DG
Sbjct: 240 NTMIAAGSCDKIIRVWCLRT--CAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGT 297
Query: 175 VRRYDLRMGQL-FS---------DYVGSPITCTCFSRDGQCTLVSSLDSTLRL--LDKDT 222
V + + L FS G + C+ FS G S D +R+ L +
Sbjct: 298 VCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEA 357
Query: 223 GELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFW 262
E + E + H ++ + C +S S DG W
Sbjct: 358 PEKIAELESHTDKVDSIQFC--NNGDRFLSGSRDGTARIW 395
Score = 47.4 bits (111), Expect = 2e-05
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA-AGSFDNSSLCSGG 86
V + +N + + +T +D LK+WN G LL GH EV FD+ + S G
Sbjct: 429 VTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAG 488
Query: 87 GDKAVVLWDVASGQVVRKF------RGHAGKVNTVQFNEE 120
D ++ +WD+ G ++ + +GH G V +F+++
Sbjct: 489 HDGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCKFSQD 527
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 80.9 bits (198), Expect = 1e-15
Identities = 82/313 (26%), Positives = 135/313 (43%), Gaps = 40/313 (12%)
Query: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGG 86
AV V F+ G+ T D +K+W+ G LL T GH E+ D A +++N+ + +G
Sbjct: 188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGS 247
Query: 87 GDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEA----TVILSGSIDSSIRC---WDCR 139
DK + +W + + V +GH G + ++QF+ A ++S D ++ C WD
Sbjct: 248 CDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTV-CFWQWDLE 306
Query: 140 SRR--PEPVQTLDEARDGV----SSVKVSDHEILAGSVDGRVRRYDL------RMGQLFS 187
S + P P++ ++ R GV SS V + GS D +R Y L ++ +L S
Sbjct: 307 SLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELES 366
Query: 188 DYVGSPITCTCFSRDGQCTLVSSLDSTLR------------LLDKDT---GELLGEYKGH 232
+ F +G L S D T R LLD T G+L E +
Sbjct: 367 H--TDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERF 424
Query: 233 KNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCL 292
+ + ++ D+ VV+ D + W+ G L L + V L HP + +
Sbjct: 425 MKPKVTM-IAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
Query: 293 LTAMG--GSVQCW 303
+ + G GS+ W
Sbjct: 484 MLSAGHDGSIFIW 496
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/220 (24%), Positives = 88/220 (40%), Gaps = 22/220 (10%)
Query: 61 RTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEE 120
R GH V A + +G D V +W +G+++ RGH+ +++ + N E
Sbjct: 180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE 239
Query: 121 ATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV------KVSDHEILAGSVDGR 174
T+I +GS D IR W R+ PV L ++S+ K S +++ DG
Sbjct: 240 NTMIAAGSCDKIIRVWCLRT--CAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGT 297
Query: 175 VRRYDLRMGQL-FS---------DYVGSPITCTCFSRDGQCTLVSSLDSTLRL--LDKDT 222
V + + L FS G + C+ FS G S D +R+ L +
Sbjct: 298 VCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEA 357
Query: 223 GELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFW 262
E + E + H ++ + C +S S DG W
Sbjct: 358 PEKIAELESHTDKVDSIQFC--NNGDRFLSGSRDGTARIW 395
Score = 47.4 bits (111), Expect = 2e-05
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA-AGSFDNSSLCSGG 86
V + +N + + +T +D LK+WN G LL GH EV FD+ + S G
Sbjct: 429 VTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAG 488
Query: 87 GDKAVVLWDVASGQVVRKF------RGHAGKVNTVQFNEE 120
D ++ +WD+ G ++ + +GH G V +F+++
Sbjct: 489 HDGSIFIWDITKGTKMKHYFNMIEGQGH-GAVFDCKFSQD 527
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 15/256 (5%)
Query: 20 TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN 79
TL +G + A+++N GNY L+ G DKT +W+ G + + H LD +N
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NN 331
Query: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
++ S D + + + + V+ F+GH +VN ++++ ++ S S D +++ W +
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 391
Query: 140 SR--------RPEPVQTLDEARDGVSSVKVSDHEILA-GSVDGRVRRYDLRMGQLFSDYV 190
+ + T+ + G ++ + + +LA S D VR +D+ G
Sbjct: 392 QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT 451
Query: 191 --GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT 248
P+ FS DG+ S D + + + +G L+ Y+G + C + R
Sbjct: 452 KHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG---IFEVCWNARGD 508
Query: 249 HVVSCSEDGKVFFWDL 264
V + + DG V DL
Sbjct: 509 KVGASASDGSVCVLDL 524
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA---- 73
+KT V A++++ G +C D TLK+W+ + + H E+
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 413
Query: 74 ---AGSFDNSS--LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGS 128
A S NS+ L S D V LWD+ G H V +V F+ + + SGS
Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS 473
Query: 129 IDSSIRCWDCRS 140
D + W+ +S
Sbjct: 474 FDKCVHIWNTQS 485
Score = 53.5 bits (127), Expect = 2e-07
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 2/107 (1%)
Query: 34 NVDGNYCLTCGS-DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVV 92
N + N L S D T++LW+ RG T + H V A S D L SG DK V
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479
Query: 93 LWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
+W+ SG +V +RG G + V +N + + + D S+ D R
Sbjct: 480 IWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 56 RGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV------ASGQVVRKFRGHA 109
+ T+LR GH EV A + + L SG GD +W++ S Q+V +
Sbjct: 173 KATVLR---GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 110 G--------KVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV 161
G V ++ +N T++ +GS D R W + TL + + + ++K
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKW 286
Query: 162 S--DHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVS-SLDSTLRLL 218
+ + IL+ VD +D G+ + T S S D + +
Sbjct: 287 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVC 346
Query: 219 DKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSG 278
+ ++GH N+ + + SCS+D + W + + L +
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIK--WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNK 404
Query: 279 VVQSLAYHPTEP 290
+ ++ + PT P
Sbjct: 405 EIYTIKWSPTGP 416
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 15/256 (5%)
Query: 20 TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN 79
TL +G + A+++N GNY L+ G DKT +W+ G + + H LD +N
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NN 331
Query: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
++ S D + + + + V+ F+GH +VN ++++ ++ S S D +++ W +
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 391
Query: 140 SR--------RPEPVQTLDEARDGVSSVKVSDHEILA-GSVDGRVRRYDLRMGQLFSDYV 190
+ + T+ + G ++ + + +LA S D VR +D+ G
Sbjct: 392 QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT 451
Query: 191 --GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT 248
P+ FS DG+ S D + + + +G L+ Y+G + C + R
Sbjct: 452 KHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG---IFEVCWNARGD 508
Query: 249 HVVSCSEDGKVFFWDL 264
V + + DG V DL
Sbjct: 509 KVGASASDGSVCVLDL 524
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA---- 73
+KT V A++++ G +C D TLK+W+ + + H E+
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 413
Query: 74 ---AGSFDNSS--LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGS 128
A S NS+ L S D V LWD+ G H V +V F+ + + SGS
Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS 473
Query: 129 IDSSIRCWDCRS 140
D + W+ +S
Sbjct: 474 FDKCVHIWNTQS 485
Score = 53.5 bits (127), Expect = 2e-07
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 2/107 (1%)
Query: 34 NVDGNYCLTCGS-DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVV 92
N + N L S D T++LW+ RG T + H V A S D L SG DK V
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479
Query: 93 LWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
+W+ SG +V +RG G + V +N + + + D S+ D R
Sbjct: 480 IWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 56 RGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV------ASGQVVRKFRGHA 109
+ T+LR GH EV A + + L SG GD +W++ S Q+V +
Sbjct: 173 KATVLR---GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 110 G--------KVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV 161
G V ++ +N T++ +GS D R W + TL + + + ++K
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKW 286
Query: 162 S--DHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVS-SLDSTLRLL 218
+ + IL+ VD +D G+ + T S S D + +
Sbjct: 287 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVC 346
Query: 219 DKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSG 278
+ ++GH N+ + + SCS+D + W + + L +
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIK--WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNK 404
Query: 279 VVQSLAYHPTEP 290
+ ++ + PT P
Sbjct: 405 EIYTIKWSPTGP 416
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 15/256 (5%)
Query: 20 TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN 79
TL +G + A+++N GNY L+ G DKT +W+ G + + H LD +N
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NN 382
Query: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
++ S D + + + + V+ F+GH +VN ++++ ++ S S D +++ W +
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
Query: 140 SR--------RPEPVQTLDEARDGVSSVKVSDHEILA-GSVDGRVRRYDLRMGQLFSDYV 190
+ + T+ + G ++ + + +LA S D VR +D+ G
Sbjct: 443 QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT 502
Query: 191 --GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT 248
P+ FS DG+ S D + + + +G L+ Y+G + C + R
Sbjct: 503 KHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG---IFEVCWNARGD 559
Query: 249 HVVSCSEDGKVFFWDL 264
V + + DG V DL
Sbjct: 560 KVGASASDGSVCVLDL 575
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA---- 73
+KT V A++++ G +C D TLK+W+ + + H E+
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 464
Query: 74 ---AGSFDNSS--LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGS 128
A S NS+ L S D V LWD+ G H V +V F+ + + SGS
Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS 524
Query: 129 IDSSIRCWDCRS 140
D + W+ +S
Sbjct: 525 FDKCVHIWNTQS 536
Score = 53.5 bits (127), Expect = 2e-07
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 2/107 (1%)
Query: 34 NVDGNYCLTCGS-DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVV 92
N + N L S D T++LW+ RG T + H V A S D L SG DK V
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
Query: 93 LWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
+W+ SG +V +RG G + V +N + + + D S+ D R
Sbjct: 531 IWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 56 RGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV------ASGQVVRKFRGHA 109
+ T+LR GH EV A + + L SG GD +W++ S Q+V +
Sbjct: 224 KATVLR---GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 110 G--------KVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV 161
G V ++ +N T++ +GS D R W + TL + + + ++K
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKW 337
Query: 162 S--DHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVS-SLDSTLRLL 218
+ + IL+ VD +D G+ + T S S D + +
Sbjct: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVC 397
Query: 219 DKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSG 278
+ ++GH N+ + + SCS+D + W + + L +
Sbjct: 398 RLGCDRPVKTFQGHTNEVNAIK--WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNK 455
Query: 279 VVQSLAYHPTEP 290
+ ++ + PT P
Sbjct: 456 EIYTIKWSPTGP 467
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 15/256 (5%)
Query: 20 TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN 79
TL +G + A+++N GNY L+ G DKT +W+ G + + H LD +N
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NN 382
Query: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
++ S D + + + + V+ F+GH +VN ++++ ++ S S D +++ W +
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
Query: 140 SR--------RPEPVQTLDEARDGVSSVKVSDHEILA-GSVDGRVRRYDLRMGQLFSDYV 190
+ + T+ + G ++ + + +LA S D VR +D+ G
Sbjct: 443 QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT 502
Query: 191 --GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT 248
P+ FS DG+ S D + + + +G L+ Y+G + C + R
Sbjct: 503 KHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG---IFEVCWNARGD 559
Query: 249 HVVSCSEDGKVFFWDL 264
V + + DG V DL
Sbjct: 560 KVGASASDGSVCVLDL 575
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDA---- 73
+KT V A++++ G +C D TLK+W+ + + H E+
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 464
Query: 74 ---AGSFDNSS--LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGS 128
A S NS+ L S D V LWD+ G H V +V F+ + + SGS
Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS 524
Query: 129 IDSSIRCWDCRS 140
D + W+ +S
Sbjct: 525 FDKCVHIWNTQS 536
Score = 53.5 bits (127), Expect = 2e-07
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 2/107 (1%)
Query: 34 NVDGNYCLTCGS-DKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVV 92
N + N L S D T++LW+ RG T + H V A S D L SG DK V
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
Query: 93 LWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
+W+ SG +V +RG G + V +N + + + D S+ D R
Sbjct: 531 IWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 25/252 (9%)
Query: 56 RGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDV------ASGQVVRKFRGHA 109
+ T+LR GH EV A + + L SG GD +W++ S Q+V +
Sbjct: 224 KATVLR---GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 110 G--------KVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV 161
G V ++ +N T++ +GS D R W + TL + + + ++K
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKW 337
Query: 162 S--DHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVS-SLDSTLRLL 218
+ + IL+ VD +D G+ + T S S D + +
Sbjct: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVC 397
Query: 219 DKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSG 278
+ ++GH N+ + + SCS+D + W + + L +
Sbjct: 398 RLGCDRPVKTFQGHTNEVNAIK--WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNK 455
Query: 279 VVQSLAYHPTEP 290
+ ++ + PT P
Sbjct: 456 EIYTIKWSPTGP 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,322,158
Number of Sequences: 37866
Number of extensions: 606422
Number of successful extensions: 4049
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1799
Number of HSP's gapped (non-prelim): 1266
length of query: 315
length of database: 18,247,518
effective HSP length: 102
effective length of query: 213
effective length of database: 14,385,186
effective search space: 3064044618
effective search space used: 3064044618
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.