Search of human proteins with 8922976

Search of human proteins with 8922976

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8922976 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 [Homo
sapiens]
         (540 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8922976 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 [Homo sapiens]  1051   0.0  
gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1 ...   175   1e-43
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi...   167   2e-41
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi...   166   5e-41
gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo sapi...   157   2e-38
gi|4503529 eukaryotic translation initiation factor 4A isoform 1...   147   2e-35
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s...   147   2e-35
gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap...   146   5e-35
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]            144   2e-34
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]            144   2e-34
gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 ...   144   3e-34
gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1...   144   3e-34
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ...   142   6e-34
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [...   142   6e-34
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ...   142   6e-34
gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo sap...   142   6e-34
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi...   142   8e-34
gi|7661920 eukaryotic translation initiation factor 4A, isoform ...   142   1e-33
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]         140   2e-33
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]          140   2e-33
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap...   140   2e-33
gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo sapi...   140   4e-33
gi|21071032 DEAD-box protein abstrakt [Homo sapiens]                  138   1e-32
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]    137   3e-32
gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo sapi...   134   3e-31
gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo sapi...   133   5e-31
gi|9506931 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 [Homo sapiens]   132   1e-30
gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo...   130   4e-30
gi|17505907 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 isoform 1 ...   129   5e-30
gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo sapi...   129   7e-30

>gi|8922976 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 [Homo sapiens]
          Length = 540

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 540/540 (100%), Positives = 540/540 (100%)

Query: 1   MALARPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPV 60
           MALARPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPV
Sbjct: 1   MALARPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPV 60

Query: 61  LVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVR 120
           LVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVR
Sbjct: 61  LVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVR 120

Query: 121 KLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTL 180
           KLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTL
Sbjct: 121 KLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTL 180

Query: 181 SYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGG 240
           SYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGG
Sbjct: 181 SYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGG 240

Query: 241 HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELV 300
           HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELV
Sbjct: 241 HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELV 300

Query: 301 DYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHC 360
           DYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHC
Sbjct: 301 DYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHC 360

Query: 361 IMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDH 420
           IMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDH
Sbjct: 361 IMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDH 420

Query: 421 KIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQD 480
           KIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQD
Sbjct: 421 KIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQD 480

Query: 481 YIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT 540
           YIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT
Sbjct: 481 YIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT 540


>gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1
           [Homo sapiens]
          Length = 455

 Score =  175 bits (443), Expect = 1e-43
 Identities = 150/436 (34%), Positives = 218/436 (50%), Gaps = 46/436 (10%)

Query: 102 ARRDHFSIERAQQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAPEV--VQPTTVQSSTI 159
           A  +H S   A Q  P V +  +K +F DLG    V   L EA  ++   +PT +Q   I
Sbjct: 3   APEEHDSPTEASQ--PIVEEEETK-TFKDLG----VTDVLCEACDQLGWTKPTKIQIEAI 55

Query: 160 PSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQV 219
           P  L+GR ++  AETGSGKT ++ LP+L  LL  P            LVL P+RELA Q+
Sbjct: 56  PLALQGRDIIGLAETGSGKTGAFALPILNALLETPQ-------RLFALVLTPTRELAFQI 108

Query: 220 RAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKS-RLISLE 278
               + LG S+G+    + GG       L L+++P   +++ATPG L   L++ +  +L 
Sbjct: 109 SEQFEALGSSIGVQSAVIVGGIDSMSQSLALAKKPH--IIIATPGRLIDHLENTKGFNLR 166

Query: 279 QLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVG 338
            L +LV+DEAD +L+  F   VD IL+       P D         +  L  AT  + V 
Sbjct: 167 ALKYLVMDEADRILNMDFETEVDKILKVI-----PRD--------RKTFLFSATMTKKV- 212

Query: 339 QLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSG 398
           Q L + A  + V    SSK   +   ++Q ++ +    K   LV+IL      E  G S 
Sbjct: 213 QKLQRAALKNPVKCAVSSKYQTV-EKLQQYYIFIPSKFKDTYLVYILN-----ELAGNS- 265

Query: 399 TVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIAS 458
             ++FC++ +       +L +     + L GQM    R+G    F+  +R ILL TD+AS
Sbjct: 266 -FMIFCSTCNNTQRTALLLRNLGFTAIPLHGQMSQSKRLGSLNKFKAKARSILLATDVAS 324

Query: 459 RGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELA 518
           RGLD   V++VVN+D P   +DYIHR GR  R G    G  I+FVT  +DV L Q+IE  
Sbjct: 325 RGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRS--GKAITFVTQ-YDVELFQRIEHL 381

Query: 519 ARRRRSLPGLASSVKE 534
             ++  LPG  +   E
Sbjct: 382 IGKK--LPGFPTQDDE 395


>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
           sapiens]
          Length = 820

 Score =  167 bits (424), Expect = 2e-41
 Identities = 126/435 (28%), Positives = 203/435 (46%), Gaps = 39/435 (8%)

Query: 87  WERAPLASQGWKSRRARRDHFSIERAQQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAP 146
           W +  L     +  R  R+ +SI     + P   +     S+ D  L P +L  + +   
Sbjct: 357 WSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIR-----SWKDSSLPPHILEVIDKCGY 411

Query: 147 EVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIP--AP 204
           +  +PT +Q   IP  L+ R ++  AETGSGKT ++L+PLL  +   P +D +      P
Sbjct: 412 K--EPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGP 469

Query: 205 RGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPG 264
             ++L P+RELAQQ+       G+ LG+    + GG        +L  +   ++++ATPG
Sbjct: 470 YAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRL--RMGCEIVIATPG 527

Query: 265 ALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKA 324
            L   L++R + L + +++VLDEAD ++D  F   V  ILE   ++    D ++  +P+ 
Sbjct: 528 RLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEK 587

Query: 325 QL-------------VLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPH--VKQTF 369
            L             V+  AT P  V +L        AV  I S+      PH  V+Q  
Sbjct: 588 MLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAG----KPHERVEQKV 643

Query: 370 LRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQG 429
             +  ++K  +L+ IL+        G    +++F N     + L   L+        L G
Sbjct: 644 FLMSESEKRKKLLAILEQ-------GFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHG 696

Query: 430 QMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVG 489
                 R     + +  ++DIL+ TD+A RG+D   V +VVNYD    ++DYIHR GR G
Sbjct: 697 GKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTG 756

Query: 490 RVGSEVPGTVISFVT 504
           R G    G  I+F+T
Sbjct: 757 RAGKS--GVAITFLT 769


>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
           sapiens]
          Length = 1031

 Score =  166 bits (420), Expect = 5e-41
 Identities = 113/381 (29%), Positives = 196/381 (51%), Gaps = 32/381 (8%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           S+   G+  ++L++L++   E  +PT +Q+  IP+++ GR ++  A+TGSGKT+++LLP+
Sbjct: 373 SWVQCGISMKILNSLKKHGYE--KPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPM 430

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
            + ++ Q SL+      P  +++ P+RELA Q+    +   ++LGL V  + GG G+   
Sbjct: 431 FRHIMDQRSLEEGE--GPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQ 488

Query: 247 RLQLSRQPSADVLVATPGALWKALKS---RLISLEQLSFLVLDEADTLLDESFLELVDYI 303
             +L R   A+++V TPG +   L +   R+ +L +++++VLDEAD + D  F   V  I
Sbjct: 489 IAELKR--GAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRI 546

Query: 304 LEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMP 363
           +             D   P  Q V+  ATFP  +  L  ++ S      +    + C   
Sbjct: 547 V-------------DNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVC--S 591

Query: 364 HVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQ 423
            V+Q  + ++   K  +L+ +L H         SG+V++F +     + L   L      
Sbjct: 592 DVEQQVIVIEEEKKFLKLLELLGHYQE------SGSVIIFVDKQEHADGLLKDLMRASYP 645

Query: 424 HLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIH 483
            + L G +    R  I   F+  +  +L+ T +A+RGLD   + LVVNY  P   +DY+H
Sbjct: 646 CMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVH 705

Query: 484 RAGRVGRVGSEVPGTVISFVT 504
           RAGR GR G++  G   +F+T
Sbjct: 706 RAGRTGRAGNK--GYAYTFIT 724


>gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo
           sapiens]
          Length = 483

 Score =  157 bits (398), Expect = 2e-38
 Identities = 127/401 (31%), Positives = 206/401 (51%), Gaps = 40/401 (9%)

Query: 128 FADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLL 187
           FA+LGL   ++   ++    + QPT VQ   IP++L GR  +  A+TGSGKT +++LP+L
Sbjct: 4   FAELGLSSWLVEQCRQLG--LKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPIL 61

Query: 188 QRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIR 247
           Q+L   P            LVL P+RELA Q+    + LG+ LGL    + GG  M    
Sbjct: 62  QKLSEDPY-------GIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQA 114

Query: 248 LQLSRQPSADVLVATPGALWKALKS-RLISLEQLSFLVLDEADTLLDESFLELVDYILE- 305
           L+LSR+P   V++ATPG L   L+S    S++++ FLV+DEAD LL++      D+ ++ 
Sbjct: 115 LELSRKPH--VVIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQG---CTDFTVDL 169

Query: 306 KSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASP----DAVTTITSSKLHCI 361
           ++ +A  PA        + Q +L  AT  + + +L     +     +A   +++      
Sbjct: 170 EAILAAVPA--------RRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVST------ 215

Query: 362 MPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHK 421
           +  + Q +L +    K A LVH+++   R +      ++++F N+  T   L  +L    
Sbjct: 216 VEQLDQRYLLVPEKVKDAYLVHLIQ---RFQDEHEDWSIIIFTNTCKTCQILCMMLRKFS 272

Query: 422 IQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDY 481
              + L   M    R      F+ S   IL+ TD+ASRGLD   V++V+N++ P   + Y
Sbjct: 273 FPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIY 332

Query: 482 IHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRR 522
           IHR GR  R G +  G  I+ VT  +D+ LV  IE   +++
Sbjct: 333 IHRVGRTARAGRQ--GQAITLVTQ-YDIHLVHAIEEQIKKK 370


>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
           [Homo sapiens]
          Length = 406

 Score =  147 bits (371), Expect = 2e-35
 Identities = 106/379 (27%), Positives = 180/379 (47%), Gaps = 35/379 (9%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SF D+ L   +L  +     E  +P+ +Q   I   ++G  V+  A++G+GKT ++ + +
Sbjct: 33  SFDDMNLSESLLRGIYAYGFE--KPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISI 90

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
           LQ++        L + A + LVL P+RELAQQ++ V   LG  +G       GG  +R  
Sbjct: 91  LQQI-------ELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRA- 142

Query: 247 RLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEK 306
            +Q  +  +  ++V TPG ++  L  R +S + +   VLDEAD +L   F + +  I +K
Sbjct: 143 EVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQK 202

Query: 307 SHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVK 366
                         N   Q+VL+ AT P  V ++  K         +   +L   +  ++
Sbjct: 203 -------------LNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEEL--TLEGIR 247

Query: 367 QTFLRLKGAD-KVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHL 425
           Q ++ ++  + K+  L  + +       T      ++F N+   V+WL   +        
Sbjct: 248 QFYINVEREEWKLDTLCDLYE-------TLTITQAVIFINTRRKVDWLTEKMHARDFTVS 300

Query: 426 RLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRA 485
            + G M    R  I + F+  S  +L+ TD+ +RG+D   V LV+NYD P   ++YIHR 
Sbjct: 301 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 360

Query: 486 GRVGRVGSEVPGTVISFVT 504
           GR GR G +  G  I+ VT
Sbjct: 361 GRGGRFGRK--GVAINMVT 377


>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
           sapiens]
          Length = 407

 Score =  147 bits (371), Expect = 2e-35
 Identities = 110/391 (28%), Positives = 186/391 (47%), Gaps = 36/391 (9%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           +F D+ L+  +L  +     E  +P+ +Q   I   ++G  V+  A++G+GKT ++ + +
Sbjct: 34  NFDDMNLKESLLRGIYAYGFE--KPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISI 91

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
           LQ+L        +     + LVL P+RELAQQ++ V   LG  +G       GG  +R  
Sbjct: 92  LQQL-------EIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRN- 143

Query: 247 RLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEK 306
            +Q  +  +  ++V TPG ++  L  R +S + +   VLDEAD +L   F + +  I +K
Sbjct: 144 EMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQK 203

Query: 307 SHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVK 366
                         N   Q+VL+ AT P  V ++  K         +   +L   +  +K
Sbjct: 204 -------------LNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEEL--TLEGIK 248

Query: 367 QTFLRLKGAD-KVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHL 425
           Q ++ ++  + K+  L  + +       T      ++F N+   V+WL   +        
Sbjct: 249 QFYINVEREEWKLDTLCDLYE-------TLTITQAVIFLNTRRKVDWLTEKMHARDFTVS 301

Query: 426 RLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRA 485
            L G M    R  I + F+  S  +L+ TD+ +RG+D   V LV+NYD P   ++YIHR 
Sbjct: 302 ALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 361

Query: 486 GRVGRVGSEVPGTVISFVTHPWDVSLVQKIE 516
           GR GR G +  G  I+FVT   D  +++ IE
Sbjct: 362 GRGGRFGRK--GVAINFVTEE-DKRILRDIE 389


>gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo
           sapiens]
          Length = 796

 Score =  146 bits (368), Expect = 5e-35
 Identities = 115/371 (30%), Positives = 180/371 (48%), Gaps = 36/371 (9%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SF D+ L   +L A+   A    QPT +Q + IP  L G+ +   A TG+GKT ++ LP+
Sbjct: 219 SFQDMNLSRPLLKAI--TAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPV 276

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
           L+RL+ +P       P  R LVLVP+REL  QV +V + L +   +      GG  ++  
Sbjct: 277 LERLIYKPR----QAPVTRVLVLVPTRELGIQVHSVTRQLAQFCNITTCLAVGGLDVKSQ 332

Query: 247 RLQLSRQPSADVLVATPGALWKALKS-RLISLEQLSFLVLDEADTLLDESFLELVDYILE 305
              L   P  D+L+ATPG L   L +     L  +  L+LDEAD +LDE F E +  I+ 
Sbjct: 333 EAALRAAP--DILIATPGRLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIR 390

Query: 306 K-SHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPH 364
             SH                Q +L  AT  + V  L + V+  + V    +S    + P 
Sbjct: 391 MCSH--------------HRQTMLFSATMTDEVKDLAS-VSLKNPVRIFVNSNTD-VAPF 434

Query: 365 VKQTFLRLKG---ADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHK 421
           ++Q F+R++     D+ A +  +L           +  V++F  +    + +  +L    
Sbjct: 435 LRQEFIRIRPNREGDREAIVAALLTRTF-------TDHVMLFTQTKKQAHRMHILLGLMG 487

Query: 422 IQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDY 481
           +Q   L G +    R+   + F+    DIL+ TD+A+RGLD  GV+ V+N+  P T++ Y
Sbjct: 488 LQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTIKHY 547

Query: 482 IHRAGRVGRVG 492
           +HR GR  R G
Sbjct: 548 VHRVGRTARAG 558


>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score =  144 bits (364), Expect = 2e-34
 Identities = 109/377 (28%), Positives = 176/377 (46%), Gaps = 44/377 (11%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SFA  G + +++H ++++  E  QPT +Q   +P  L GR ++  A+TGSGKT +++ P+
Sbjct: 254 SFAHFGFDEQLMHQIRKS--EYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPM 311

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
           L  ++ Q  L+  P   P  +++ P+REL QQ+ A  +  G++  L    + GG  M   
Sbjct: 312 LIHIMDQKELE--PGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQ 369

Query: 247 RLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEK 306
              L  Q  A+++V TPG L   +K +  +L+++S+LV DEAD + D  F   V  I   
Sbjct: 370 AKAL--QEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSI--A 425

Query: 307 SHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVK 366
           SH+            P  Q +L  ATF + + +L            I    +  +   + 
Sbjct: 426 SHV-----------RPDRQTLLFSATFRKKIEKL---------ARDILIDPIRVVQGDIG 465

Query: 367 QTFLRLKGADKVAELVHILKH---------RDRAERTGPSGTVLVFCNSSSTVNWLGYIL 417
           +        + V ++V IL           R   E T  SG+VL+F    +    L   L
Sbjct: 466 E------ANEDVTQIVEILHSGPSKWNWLTRRLVEFTS-SGSVLLFVTKKANAEELANNL 518

Query: 418 DDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPT 477
                    L G M    R  +   F+K    +L+ TD+A+RGLD   ++ V+NYD    
Sbjct: 519 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARD 578

Query: 478 LQDYIHRAGRVGRVGSE 494
           +  + HR GR GR G +
Sbjct: 579 IDTHTHRIGRTGRAGEK 595


>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score =  144 bits (364), Expect = 2e-34
 Identities = 109/377 (28%), Positives = 176/377 (46%), Gaps = 44/377 (11%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SFA  G + +++H ++++  E  QPT +Q   +P  L GR ++  A+TGSGKT +++ P+
Sbjct: 254 SFAHFGFDEQLMHQIRKS--EYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPM 311

Query: 187 LQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRI 246
           L  ++ Q  L+  P   P  +++ P+REL QQ+ A  +  G++  L    + GG  M   
Sbjct: 312 LIHIMDQKELE--PGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQ 369

Query: 247 RLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEK 306
              L  Q  A+++V TPG L   +K +  +L+++S+LV DEAD + D  F   V  I   
Sbjct: 370 AKAL--QEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSI--A 425

Query: 307 SHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVK 366
           SH+            P  Q +L  ATF + + +L            I    +  +   + 
Sbjct: 426 SHV-----------RPDRQTLLFSATFRKKIEKL---------ARDILIDPIRVVQGDIG 465

Query: 367 QTFLRLKGADKVAELVHILKH---------RDRAERTGPSGTVLVFCNSSSTVNWLGYIL 417
           +        + V ++V IL           R   E T  SG+VL+F    +    L   L
Sbjct: 466 E------ANEDVTQIVEILHSGPSKWNWLTRRLVEFTS-SGSVLLFVTKKANAEELANNL 518

Query: 418 DDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPT 477
                    L G M    R  +   F+K    +L+ TD+A+RGLD   ++ V+NYD    
Sbjct: 519 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARD 578

Query: 478 LQDYIHRAGRVGRVGSE 494
           +  + HR GR GR G +
Sbjct: 579 IDTHTHRIGRTGRAGEK 595


>gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2
           [Homo sapiens]
          Length = 881

 Score =  144 bits (362), Expect = 3e-34
 Identities = 122/417 (29%), Positives = 186/417 (44%), Gaps = 37/417 (8%)

Query: 120 RKLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKT 179
           +K    G F  +GL   V   + +   +V  PT +Q  TIP +L G+ VV  A TGSGKT
Sbjct: 90  KKKKKSGGFQSMGLSYPVFKGIMKKGYKV--PTPIQRKTIPVILDGKDVVAMARTGSGKT 147

Query: 180 LSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEG 239
             +LLP+ +RL    +         R L+L P+RELA Q     + LG+  GL    + G
Sbjct: 148 ACFLLPMFERLKTHSAQTGA-----RALILSPTRELALQTLKFTKELGKFTGLKTALILG 202

Query: 240 GHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLEL 299
           G  M      L   P  D+++ATPG L        + L+ + ++V DEAD L +  F E 
Sbjct: 203 GDRMEDQFAALHENP--DIIIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQ 260

Query: 300 VDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNK-VASPDAVTTITSSKL 358
           +  I     IA  P           Q VL  AT P+ + +     +  P  +     +KL
Sbjct: 261 LQEI-----IARLPGG--------HQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKL 307

Query: 359 HCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILD 418
           +     +K +F  ++   K A L+H+L +  R     P    +VF  +     +L  +L 
Sbjct: 308 N---EQLKTSFFLVREDTKAAVLLHLLHNVVR-----PQDQTVVFVATKHHAEYLTELLT 359

Query: 419 DHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTL 478
             ++    +   +    R      F       L+ TD+A+RGLD   ++ V+NY FP   
Sbjct: 360 TQRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKG 419

Query: 479 QDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEP 535
           + ++HR GRV R G    GT  S V  P ++  +  + L   R  +   LA  +KEP
Sbjct: 420 KLFLHRVGRVARAGRS--GTAYSLVA-PDEIPYLLDLHLFLGRSLT---LARPLKEP 470


>gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1
           [Homo sapiens]
          Length = 882

 Score =  144 bits (362), Expect = 3e-34
 Identities = 122/417 (29%), Positives = 186/417 (44%), Gaps = 37/417 (8%)

Query: 120 RKLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKT 179
           +K    G F  +GL   V   + +   +V  PT +Q  TIP +L G+ VV  A TGSGKT
Sbjct: 90  KKKKKSGGFQSMGLSYPVFKGIMKKGYKV--PTPIQRKTIPVILDGKDVVAMARTGSGKT 147

Query: 180 LSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEG 239
             +LLP+ +RL    +         R L+L P+RELA Q     + LG+  GL    + G
Sbjct: 148 ACFLLPMFERLKTHSAQTGA-----RALILSPTRELALQTLKFTKELGKFTGLKTALILG 202

Query: 240 GHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLEL 299
           G  M      L   P  D+++ATPG L        + L+ + ++V DEAD L +  F E 
Sbjct: 203 GDRMEDQFAALHENP--DIIIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQ 260

Query: 300 VDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNK-VASPDAVTTITSSKL 358
           +  I     IA  P           Q VL  AT P+ + +     +  P  +     +KL
Sbjct: 261 LQEI-----IARLPGG--------HQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKL 307

Query: 359 HCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILD 418
           +     +K +F  ++   K A L+H+L +  R     P    +VF  +     +L  +L 
Sbjct: 308 N---EQLKTSFFLVREDTKAAVLLHLLHNVVR-----PQDQTVVFVATKHHAEYLTELLT 359

Query: 419 DHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTL 478
             ++    +   +    R      F       L+ TD+A+RGLD   ++ V+NY FP   
Sbjct: 360 TQRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKG 419

Query: 479 QDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEP 535
           + ++HR GRV R G    GT  S V  P ++  +  + L   R  +   LA  +KEP
Sbjct: 420 KLFLHRVGRVARAGRS--GTAYSLVA-PDEIPYLLDLHLFLGRSLT---LARPLKEP 470


>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
           [Homo sapiens]
          Length = 724

 Score =  142 bits (359), Expect = 6e-34
 Identities = 110/372 (29%), Positives = 179/372 (48%), Gaps = 35/372 (9%)

Query: 152 TTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLL--GQPSLDSLPIPAPRGLVL 209
           T VQ  +IP +L GR ++  A+TGSGKT ++LLP+L  ++  G  +     +  P  +++
Sbjct: 312 TPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIV 371

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDL------EGGHGMRRIRLQLSRQPSADVLVATP 263
            P+REL  Q+   A+    S G  VR +      + GH +R+I          ++L ATP
Sbjct: 372 APTRELVNQIYLEARKF--SFGTCVRAVVIYGGTQLGHSIRQI------VQGCNILCATP 423

Query: 264 GALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPK 323
           G L   +    I L+Q+ +LVLDEAD +LD  F   +  ++    +         P   +
Sbjct: 424 GRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGM---------PSKEQ 474

Query: 324 AQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVH 383
            Q ++  ATFPE + +L  +    + +  +   ++      V+QT L++    K  +LV 
Sbjct: 475 RQTLMFSATFPEEIQRLAAEFLKSNYLF-VAVGQVGGACRDVQQTVLQVGQFSKREKLVE 533

Query: 384 ILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSF 443
           IL++    ERT      +VF  +    +++   L   KI    + G      R      F
Sbjct: 534 ILRNIGD-ERT------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDF 586

Query: 444 QKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFV 503
           +     +L+ T +A+RGLD   V+ V+N+D P T+ +Y+HR GR GR G+   G  ISF 
Sbjct: 587 RFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGN--TGRAISFF 644

Query: 504 THPWDVSLVQKI 515
               D  L Q +
Sbjct: 645 DLESDNHLAQPL 656


>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
           [Homo sapiens]
          Length = 724

 Score =  142 bits (359), Expect = 6e-34
 Identities = 110/372 (29%), Positives = 179/372 (48%), Gaps = 35/372 (9%)

Query: 152 TTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLL--GQPSLDSLPIPAPRGLVL 209
           T VQ  +IP +L GR ++  A+TGSGKT ++LLP+L  ++  G  +     +  P  +++
Sbjct: 312 TPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIV 371

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDL------EGGHGMRRIRLQLSRQPSADVLVATP 263
            P+REL  Q+   A+    S G  VR +      + GH +R+I          ++L ATP
Sbjct: 372 APTRELVNQIYLEARKF--SFGTCVRAVVIYGGTQLGHSIRQI------VQGCNILCATP 423

Query: 264 GALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPK 323
           G L   +    I L+Q+ +LVLDEAD +LD  F   +  ++    +         P   +
Sbjct: 424 GRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGM---------PSKEQ 474

Query: 324 AQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVH 383
            Q ++  ATFPE + +L  +    + +  +   ++      V+QT L++    K  +LV 
Sbjct: 475 RQTLMFSATFPEEIQRLAAEFLKSNYLF-VAVGQVGGACRDVQQTVLQVGQFSKREKLVE 533

Query: 384 ILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSF 443
           IL++    ERT      +VF  +    +++   L   KI    + G      R      F
Sbjct: 534 ILRNIGD-ERT------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDF 586

Query: 444 QKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFV 503
           +     +L+ T +A+RGLD   V+ V+N+D P T+ +Y+HR GR GR G+   G  ISF 
Sbjct: 587 RFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGN--TGRAISFF 644

Query: 504 THPWDVSLVQKI 515
               D  L Q +
Sbjct: 645 DLESDNHLAQPL 656


>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
           [Homo sapiens]
          Length = 690

 Score =  142 bits (359), Expect = 6e-34
 Identities = 110/372 (29%), Positives = 179/372 (48%), Gaps = 35/372 (9%)

Query: 152 TTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLL--GQPSLDSLPIPAPRGLVL 209
           T VQ  +IP +L GR ++  A+TGSGKT ++LLP+L  ++  G  +     +  P  +++
Sbjct: 278 TPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIV 337

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDL------EGGHGMRRIRLQLSRQPSADVLVATP 263
            P+REL  Q+   A+    S G  VR +      + GH +R+I          ++L ATP
Sbjct: 338 APTRELVNQIYLEARKF--SFGTCVRAVVIYGGTQLGHSIRQI------VQGCNILCATP 389

Query: 264 GALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPK 323
           G L   +    I L+Q+ +LVLDEAD +LD  F   +  ++    +         P   +
Sbjct: 390 GRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGM---------PSKEQ 440

Query: 324 AQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVH 383
            Q ++  ATFPE + +L  +    + +  +   ++      V+QT L++    K  +LV 
Sbjct: 441 RQTLMFSATFPEEIQRLAAEFLKSNYLF-VAVGQVGGACRDVQQTVLQVGQFSKREKLVE 499

Query: 384 ILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSF 443
           IL++    ERT      +VF  +    +++   L   KI    + G      R      F
Sbjct: 500 ILRNIGD-ERT------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDF 552

Query: 444 QKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFV 503
           +     +L+ T +A+RGLD   V+ V+N+D P T+ +Y+HR GR GR G+   G  ISF 
Sbjct: 553 RFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGN--TGRAISFF 610

Query: 504 THPWDVSLVQKI 515
               D  L Q +
Sbjct: 611 DLESDNHLAQPL 622


>gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo
           sapiens]
          Length = 619

 Score =  142 bits (359), Expect = 6e-34
 Identities = 119/384 (30%), Positives = 188/384 (48%), Gaps = 41/384 (10%)

Query: 135 PRVL-HALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQ 193
           P VL H L+++  EV  PT +Q   IP  L GR ++ +A+TGSGKT ++LLP++ R L +
Sbjct: 211 PEVLNHNLKKSGYEV--PTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFE 268

Query: 194 PSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQ 253
                     P  L+L P+RELA Q+   A+ L   L  +   L  G G+         Q
Sbjct: 269 SK-------TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVG-GLPLPPQLYRLQ 320

Query: 254 PSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGP 313
               V++ATPG L   +K   + L  +  +V+DEADT+L   F + V  ILE       P
Sbjct: 321 QHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENI-----P 375

Query: 314 ADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSK-LHCIMPHVKQTFLRL 372
            D         Q +LV AT P  + QL +++   + V  IT  K L C   +V+Q  L +
Sbjct: 376 ND--------CQTILVSATIPTSIEQLASQLLH-NPVRIITGEKNLPCA--NVRQIILWV 424

Query: 373 KGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHK-IQHLRLQGQM 431
           +   K  +L  IL  +   +       VLVF +     + L   +     ++ + +  + 
Sbjct: 425 EDPAKKKKLFEILNDKKLFKPP-----VLVFVDCKLGADLLSEAVQKITGLKSISIHSEK 479

Query: 432 PALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRV 491
             + R  I +   +   ++++ T +  RGLD   V LVVN+D P ++ +Y+H+ GRVGR+
Sbjct: 480 SQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRL 539

Query: 492 GSEVPGTVISFVTHP-----WDVS 510
           G    GT I+F+ +      WD++
Sbjct: 540 GQN--GTAITFINNNSKRLFWDIA 561


>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
           sapiens]
          Length = 483

 Score =  142 bits (358), Expect = 8e-34
 Identities = 113/386 (29%), Positives = 187/386 (48%), Gaps = 40/386 (10%)

Query: 123 SSKGS-FADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLS 181
           S+KG+ F D  L+  +L  + E   E  +P+ +Q  +IP  L GR ++  A+ G+GK+ +
Sbjct: 92  STKGNEFEDYCLKRELLMGIFEMGWE--KPSPIQEESIPIALSGRDILARAKNGTGKSGA 149

Query: 182 YLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLG-LLVRDLEGG 240
           YL+PLL+RL        L     + +V+VP+RELA QV  +   + + +G   V    GG
Sbjct: 150 YLIPLLERL-------DLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGG 202

Query: 241 HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELV 300
             +R   ++L    +  V++ATPG +   +K  +  ++ +  +VLDEAD LL + F++++
Sbjct: 203 TNLRDDIMRLD--DTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIM 260

Query: 301 DYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNK-VASPDAVTTITSSKLH 359
           + I+           L  P N   Q++L  ATFP  V + +N  +  P  +  +    L 
Sbjct: 261 EDII-----------LTLPKN--RQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLK 307

Query: 360 CIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDD 419
            +  +      R K        VH L       +   S   ++FCNSS  V  L   +  
Sbjct: 308 GVTQYYAYVTERQK--------VHCLNTLFSRLQINQS---IIFCNSSQRVELLAKKISQ 356

Query: 420 HKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQ 479
                  +  +M    R  +F  F+      L+CTD+ +RG+D   V +V+N+DFP   +
Sbjct: 357 LGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAE 416

Query: 480 DYIHRAGRVGRVGSEVPGTVISFVTH 505
            Y+HR GR GR G    G  I+ +T+
Sbjct: 417 TYLHRIGRSGRFGH--LGLAINLITY 440


>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
           [Homo sapiens]
          Length = 411

 Score =  142 bits (357), Expect = 1e-33
 Identities = 109/431 (25%), Positives = 199/431 (46%), Gaps = 46/431 (10%)

Query: 90  APLASQGWKSRRARRDHFSIERAQQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAPEVV 149
           A +A+ G   +R  ++    +  + E     ++    +F  +GL   +L  +     E  
Sbjct: 5   ATMATSGSARKRLLKEE---DMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFE-- 59

Query: 150 QPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVL 209
           +P+ +Q   I  +++GR V+  +++G+GKT ++ + +LQ L        + +   + L+L
Sbjct: 60  KPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCL-------DIQVRETQALIL 112

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKA 269
            P+RELA Q++     LG  + +      GG  +     +L       V+  TPG ++  
Sbjct: 113 APTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDY--GQHVVAGTPGRVFDM 170

Query: 270 LKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLV 329
           ++ R +    +  LVLDEAD +L++ F E +              D+     P  Q+VL+
Sbjct: 171 IRRRSLRTRAIKMLVLDEADEMLNKGFKEQI-------------YDVYRYLPPATQVVLI 217

Query: 330 GATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGA----DKVAELVHIL 385
            AT P  + ++ NK  +      +   +L   +  +KQ F+ ++      D + +L   L
Sbjct: 218 SATLPHEILEMTNKFMTDPIRILVKRDEL--TLEGIKQFFVAVEREEWKFDTLCDLYDTL 275

Query: 386 KHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQK 445
                          ++FCN+   V+WL   + +       + G MP   R  I + F+ 
Sbjct: 276 TITQ----------AVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRS 325

Query: 446 SSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTH 505
            +  +L+ TD+ +RGLD   V L++NYD P   + YIHR GR GR G +  G  I+FV +
Sbjct: 326 GASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRK--GVAINFVKN 383

Query: 506 PWDVSLVQKIE 516
             D+ +++ IE
Sbjct: 384 D-DIRILRDIE 393


>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
          Length = 731

 Score =  140 bits (354), Expect = 2e-33
 Identities = 110/355 (30%), Positives = 162/355 (45%), Gaps = 24/355 (6%)

Query: 150 QPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVL 209
           +PT +Q    P  L GR +V  A+TGSGKTL+YLLP +  +  QP L+      P  LVL
Sbjct: 193 EPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGD--GPICLVL 250

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKA 269
            P+RELAQQV+ VA   G+   L    + GG         L R    ++ +ATPG L   
Sbjct: 251 APTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLER--GVEICIATPGRLIDF 308

Query: 270 LKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLV 329
           L+S   +L + ++LVLDEAD +LD  F   +  I+             D   P  Q ++ 
Sbjct: 309 LESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIV-------------DQIRPDRQTLMW 355

Query: 330 GATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRD 389
            AT+P+ V QL     + D +   T   +  +        L++      +E  H L    
Sbjct: 356 SATWPKEVRQL-----AEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLM 410

Query: 390 RAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRD 449
                      ++F  +    + L   +       + + G      R  +   F+     
Sbjct: 411 EEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAP 470

Query: 450 ILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVT 504
           IL+ TD+ASRGLD   V+ V+NYD+P + +DY+HR GR  R  S   GT  +F T
Sbjct: 471 ILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTAR--STNKGTAYTFFT 523


>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
          Length = 729

 Score =  140 bits (354), Expect = 2e-33
 Identities = 110/355 (30%), Positives = 162/355 (45%), Gaps = 24/355 (6%)

Query: 150 QPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVL 209
           +PT +Q    P  L GR +V  A+TGSGKTL+YLLP +  +  QP L+      P  LVL
Sbjct: 193 EPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGD--GPICLVL 250

Query: 210 VPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKA 269
            P+RELAQQV+ VA   G+   L    + GG         L R    ++ +ATPG L   
Sbjct: 251 APTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLER--GVEICIATPGRLIDF 308

Query: 270 LKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLV 329
           L+S   +L + ++LVLDEAD +LD  F   +  I+             D   P  Q ++ 
Sbjct: 309 LESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIV-------------DQIRPDRQTLMW 355

Query: 330 GATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRD 389
            AT+P+ V QL     + D +   T   +  +        L++      +E  H L    
Sbjct: 356 SATWPKEVRQL-----AEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLM 410

Query: 390 RAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRD 449
                      ++F  +    + L   +       + + G      R  +   F+     
Sbjct: 411 EEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAP 470

Query: 450 ILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVT 504
           IL+ TD+ASRGLD   V+ V+NYD+P + +DY+HR GR  R  S   GT  +F T
Sbjct: 471 ILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTAR--STNKGTAYTFFT 523


>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
           sapiens]
          Length = 648

 Score =  140 bits (354), Expect = 2e-33
 Identities = 118/400 (29%), Positives = 189/400 (47%), Gaps = 28/400 (7%)

Query: 135 PRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQP 194
           P V+  +++A  +  +PT +QS   P +L+G  ++  A+TG+GKTL YL+P    L+ QP
Sbjct: 251 PEVMENIKKAGFQ--KPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQP 308

Query: 195 SLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQP 254
           SL       P  LVL P+RELA QV           GL    + GG G R  +++  ++ 
Sbjct: 309 SLKGQR-NRPGMLVLTPTRELALQVEGECCKYSYK-GLRSVCVYGG-GNRDEQIEELKK- 364

Query: 255 SADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPA 314
             D+++ATPG L     S  ++L+ +++LVLDEAD +LD  F   +  IL          
Sbjct: 365 GVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLD-------- 416

Query: 315 DLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKG 374
                  P  Q V+  AT+P  V +L         +  + +  L  +   VKQ  +    
Sbjct: 417 -----VRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSS-VKQNIIVTTE 470

Query: 375 ADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPAL 434
            +K + +   L+     ++      V+VF +  +  + L   L    I    L G     
Sbjct: 471 EEKWSHMQTFLQSMSSTDK------VIVFVSRKAVADHLSSDLILGNISVESLHGDREQR 524

Query: 435 MRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSE 494
            R    ++F+     IL+ TD+ASRGLD   V  V N+DFP  +++Y+HR GR GR G  
Sbjct: 525 DREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG-R 583

Query: 495 VPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKE 534
              ++ +   + W V+  + I +  R  +S+P    S+ E
Sbjct: 584 TGVSITTLTRNDWRVA-SELINILERANQSIPEELVSMAE 622


>gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo
           sapiens]
          Length = 631

 Score =  140 bits (352), Expect = 4e-33
 Identities = 114/384 (29%), Positives = 173/384 (45%), Gaps = 36/384 (9%)

Query: 148 VVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIP----- 202
           +V+PT +QS   P +L+G  ++  A+TG+GKTLSYL+P      G   LDS PI      
Sbjct: 242 IVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMP------GFIHLDSQPISREQRN 295

Query: 203 APRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVAT 262
            P  LVL P+RELA  V A         GL    + GG         +S+    D+++AT
Sbjct: 296 GPGMLVLTPTRELALHVEAECSKYSYK-GLKSICIYGGRNRNGQIEDISK--GVDIIIAT 352

Query: 263 PGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNP 322
           PG L     +  ++L  +++LV+DEAD +LD  F   +  IL                 P
Sbjct: 353 PGRLNDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLD-------------VRP 399

Query: 323 KAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELV 382
             Q V+  AT+P+ V QL         +  + +  L  +   VKQ  +     +K A   
Sbjct: 400 DRQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNT-VKQNIIVTTEKEKRALT- 457

Query: 383 HILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQS 442
                ++  E   P+  V++F +     + L    +   I    L G      +    + 
Sbjct: 458 -----QEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVED 512

Query: 443 FQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISF 502
           F+  +  IL+ TDI SRGLD   V  V NYDFP  +  Y+HR G +GR G    GT ++ 
Sbjct: 513 FKSGNIKILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGK--TGTSVTL 570

Query: 503 VTHPWDVSLVQKIELAARRRRSLP 526
           +T        + I++  R  +S+P
Sbjct: 571 ITQRDSKMAGELIKILDRANQSVP 594


>gi|21071032 DEAD-box protein abstrakt [Homo sapiens]
          Length = 622

 Score =  138 bits (348), Expect = 1e-32
 Identities = 114/397 (28%), Positives = 188/397 (47%), Gaps = 36/397 (9%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SF ++     +L  L++    +  PT +Q   IP++L GR ++  A TGSGKTL + LP+
Sbjct: 182 SFKEMKFPAAILRGLKKKG--IHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPV 239

Query: 187 LQRLLGQPSLDSLPIP---APRGLVLVPSRELAQQVRAVAQPLGRSL----GLLVRDLEG 239
           +   L Q     LP      P GL++ PSRELA+Q   + +   R L      L+R    
Sbjct: 240 IMFCLEQEK--RLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALC 297

Query: 240 GHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLEL 299
             GM       + +    ++VATPG L   L+ +++SL+   +L LDEAD ++D  F   
Sbjct: 298 IGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGD 357

Query: 300 VDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLH 359
           +  I                F  + Q +L  AT P+ + Q   K A    VT I   +  
Sbjct: 358 IRTIFSY-------------FKGQRQTLLFSATMPKKI-QNFAKSALVKPVT-INVGRAG 402

Query: 360 CIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDD 419
                V Q    +K   K+  L+  L      ++T P   VL+F    + V+ +   L  
Sbjct: 403 AASLDVIQEVEYVKEEAKMVYLLECL------QKTPPP--VLIFAEKKADVDAIHEYLLL 454

Query: 420 HKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQ 479
             ++ + + G      R    ++F++  +D+L+ TD+AS+GLD   ++ V+NYD P  ++
Sbjct: 455 KGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIE 514

Query: 480 DYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIE 516
           +Y+HR GR GR G+   G   +F+    D S++  ++
Sbjct: 515 NYVHRIGRTGRSGN--TGIATTFINKACDESVLMDLK 549


>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
          Length = 614

 Score =  137 bits (344), Expect = 3e-32
 Identities = 112/370 (30%), Positives = 165/370 (44%), Gaps = 42/370 (11%)

Query: 144 AAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPA 203
           A     +PT +Q+   P  L G  +V  A+TGSGKTLSYLLP +  +  QP L+      
Sbjct: 110 ARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGD--G 167

Query: 204 PRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATP 263
           P  LVL P+RELAQQV+ VA    R+  L    + GG         L R    ++ +ATP
Sbjct: 168 PICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLER--GVEICIATP 225

Query: 264 GALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPK 323
           G L   L+    +L + ++LVLDEAD +LD  F   +  I+             D   P 
Sbjct: 226 GRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV-------------DQIRPD 272

Query: 324 AQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVH 383
            Q ++  AT+P+ V QL       D +             H+    L L     + ++V 
Sbjct: 273 RQTLMWSATWPKEVRQLAEDFLK-DYI-------------HINIGALELSANHNILQIVD 318

Query: 384 ILKHRDRAER---------TGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPAL 434
           +    ++ E+         +      +VF  +    + L   +       + + G     
Sbjct: 319 VCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQ 378

Query: 435 MRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSE 494
            R  +   F+     IL+ TD+ASRGLD   V+ V+NYD+P + +DYIHR GR  R  S 
Sbjct: 379 ERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTAR--ST 436

Query: 495 VPGTVISFVT 504
             GT  +F T
Sbjct: 437 KTGTAYTFFT 446


>gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo
           sapiens]
          Length = 875

 Score =  134 bits (336), Expect = 3e-31
 Identities = 128/464 (27%), Positives = 214/464 (46%), Gaps = 61/464 (13%)

Query: 70  SARRPELNQPARLTLGRWERAPLASQGWKSRRARR--------DHFSIERAQQEAPAVRK 121
           S  RP+   P R +  RW++     Q  K +  ++        +  SI R  Q    +  
Sbjct: 10  SGARPD---PVR-SFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKIN- 64

Query: 122 LSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLS 181
           ++    F+D  L  + L  LQEA   +V  T +Q  TI   L+G+ V+ AA+TGSGKTL+
Sbjct: 65  VNEITRFSDFPLSKKTLKGLQEAQYRLV--TEIQKQTIGLALQGKDVLGAAKTGSGKTLA 122

Query: 182 YLLPLLQRL--LGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGR----SLGLLVR 235
           +L+P+L+ L  L   S D L +     L++ P+RELA Q   V + +G+    S GL++ 
Sbjct: 123 FLVPVLEALYRLQWTSTDGLGV-----LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIG 177

Query: 236 DLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRL-ISLEQLSFLVLDEADTLLDE 294
             +  H   RI        + ++LV TPG L + +   +      L  LVLDEAD +LD 
Sbjct: 178 GKDLKHEAERIN-------NINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDM 230

Query: 295 SFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLN-KVASPDAVTTI 353
            F + ++ ++E                 K Q +L  AT  + V  L    + +P+ V   
Sbjct: 231 GFADTMNAVIEN-------------LPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 277

Query: 354 TSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWL 413
             +K +     ++Q ++  +   K++ L   L+   + +        +VF +S   V +L
Sbjct: 278 EKAK-YSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKS-------IVFFSSCKEVQYL 329

Query: 414 GYILDDHK--IQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVN 471
             +    +  +  L L G+   + R+ ++  F +    +L  TDIA+RGLD   V  V+ 
Sbjct: 330 YRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQ 389

Query: 472 YDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKI 515
           +D P     YIHRAGR  R   +    +I     P + ++VQ++
Sbjct: 390 FDCPEDANTYIHRAGRTARYKEDGEALLILL---PSEKAMVQQL 430


>gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo
           sapiens]
          Length = 783

 Score =  133 bits (334), Expect = 5e-31
 Identities = 116/407 (28%), Positives = 191/407 (46%), Gaps = 37/407 (9%)

Query: 113 QQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAA 172
           +QE P  +K   +G+F++  +    +  L+      + P  +Q+ T   +  G+ ++  A
Sbjct: 176 EQEIPVEQK---EGAFSNFPISEETIKLLKGRGVTFLFP--IQAKTFHHVYSGKDLIAQA 230

Query: 173 ETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGL 232
            TG+GKT S+ +PL+++L G+   D     AP+ LVL P+RELA QV      + + L  
Sbjct: 231 RTGTGKTFSFAIPLIEKLHGELQ-DRKRGRAPQVLVLAPTRELANQVSKDFSDITKKLS- 288

Query: 233 LVRDLEGG--HGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADT 290
            V    GG  +G +  R++       D+LV TPG +   +++  + L +L  +VLDE D 
Sbjct: 289 -VACFYGGTPYGGQFERMR----NGIDILVGTPGRIKDHIQNGKLDLTKLKHVVLDEVDQ 343

Query: 291 LLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNK-VASPDA 349
           +LD  F + V+ IL  ++      D ED  NP  Q +L  AT P  V  +  K + S   
Sbjct: 344 MLDMGFADQVEEILSVAY----KKDSED--NP--QTLLFSATCPHWVFNVAKKYMKSTYE 395

Query: 350 VTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSST 409
              +   K       V+   ++     + A +  +++       +G  G  ++FC +   
Sbjct: 396 QVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIR-----VYSGHQGRTIIFCETKKE 450

Query: 410 VNWLGY---ILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGV 466
              L     I  D +  H    G +P   R    + F+  S  +L+ T++A+RGLD   V
Sbjct: 451 AQELSQNSAIKQDAQSLH----GDIPQKQREITLKGFRNGSFGVLVATNVAARGLDIPEV 506

Query: 467 ELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQ 513
           +LV+    P  ++ YIHR+GR GR G    G  I F  H  +  LVQ
Sbjct: 507 DLVIQSSPPKDVESYIHRSGRTGRAGR--TGVCICFYQHKEEYQLVQ 551


>gi|9506931 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 [Homo sapiens]
          Length = 547

 Score =  132 bits (331), Expect = 1e-30
 Identities = 120/407 (29%), Positives = 177/407 (43%), Gaps = 57/407 (14%)

Query: 128 FADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLL 187
           F  +GL+PR+L A+ +      +PT +Q   IP  L G+ ++  A TGSGKT +Y +P+L
Sbjct: 9   FEHMGLDPRLLQAVTDLGWS--RPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPML 66

Query: 188 QRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIR 247
           Q LL + +   +   A RGLVLVP++ELA+Q +++ Q L       VR          + 
Sbjct: 67  QLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSVS 126

Query: 248 LQLSRQPSADVLVATPGALWKALKSRLISL-EQLSFLVLDEADTLLDESFLELVDYILEK 306
            +       DV+V TP  +   L+   + L + L  LV+DEAD L    F E +  +L  
Sbjct: 127 QRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLL-- 184

Query: 307 SHIAEGPADLEDPFNPKA-QLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHV 365
            H+            P+  Q  L+ ATF E V  L   +        +  S+L    P  
Sbjct: 185 CHL------------PRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLP--GPDQ 230

Query: 366 KQTFLRL--KGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQ 423
            Q F  +     DK   L  +LK       +   G  L+F N+      L   L+   I 
Sbjct: 231 LQQFQVVCETEEDKFLLLYALLK------LSLIRGKSLLFVNTLERSYRLRLFLEQFSIP 284

Query: 424 HLRLQGQMPALMRVGIFQSFQKSSRDILLCTDI--------------------------- 456
              L G++P   R  I   F +   D ++ TD                            
Sbjct: 285 TCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAG 344

Query: 457 ASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFV 503
            +RG+D   V  V+N+D PPT + YIHRAGR  R  +  PG V++FV
Sbjct: 345 VARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANN--PGIVLTFV 389


>gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo
           sapiens]
          Length = 662

 Score =  130 bits (326), Expect = 4e-30
 Identities = 107/393 (27%), Positives = 172/393 (43%), Gaps = 62/393 (15%)

Query: 127 SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPL 186
           SF+D+ +   ++  ++       +PT VQ   IP +   R ++  A+TGSGKT ++LLP+
Sbjct: 181 SFSDVEMGEIIMGNIE--LTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPI 238

Query: 187 LQRLLGQPSLDSLPIPAPRG-----------LVLVPSRELAQQVRAVAQPL--------- 226
           L ++      ++L      G           LVL P+RELA Q+   A+           
Sbjct: 239 LSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPC 298

Query: 227 ----GRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSF 282
               G  +G  +RDLE G                 +LVATPG L   ++   I L+   +
Sbjct: 299 VVYGGADIGQQIRDLERG---------------CHLLVATPGRLVDMMERGKIGLDFCKY 343

Query: 283 LVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKA--QLVLVGATFPEGVGQL 340
           LVLDEAD +LD  F   +  I+E           +D   PK     ++  ATFP+ +  L
Sbjct: 344 LVLDEADRMLDMGFEPQIRRIVE-----------QDTMPPKGVRHTMMFSATFPKEIQML 392

Query: 341 LNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTV 400
                  D    +   ++     ++ Q  + ++ +DK + L+ +L        TG     
Sbjct: 393 ARDFL--DEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLN------ATGKDSLT 444

Query: 401 LVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRG 460
           LVF  +    + L   L         + G      R      F+     IL+ T +A+RG
Sbjct: 445 LVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARG 504

Query: 461 LDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGS 493
           LD + V+ V+N+D P  +++Y+HR GR GRVG+
Sbjct: 505 LDISNVKHVINFDLPSDIEEYVHRIGRTGRVGN 537


>gi|17505907 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 isoform 1
           [Homo sapiens]
          Length = 851

 Score =  129 bits (325), Expect = 5e-30
 Identities = 123/414 (29%), Positives = 189/414 (45%), Gaps = 57/414 (13%)

Query: 121 KLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTL 180
           K+ +  +F +LGL P ++  +     ++   T+VQ  +IP LL GR  +  ++TGSGKTL
Sbjct: 225 KVFTSAAFHELGLHPHLISTINTVL-KMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTL 283

Query: 181 SYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRD-LEG 239
           +Y +P++Q L    S        P  LVLVP+RELA Q     Q L +    +V   L G
Sbjct: 284 AYCIPVVQSLQAMESKIQRS-DGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMG 342

Query: 240 GHGMRRIRLQLSRQPSADVLVATPGALWKALKS-RLISLEQLSFLVLDEADTLLDESFLE 298
           G   +  + +L +    ++L++TPG L   +KS + I   +L +LV DEAD +LD  F +
Sbjct: 343 GEKRKSEKARLRK--GINILISTPGRLVDHIKSTKNIHFSRLRWLVFDEADRILDLGFEK 400

Query: 299 LVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKL 358
            +  IL   +     A+ +     K Q VL+ AT  EGV +L + ++  D V+     K 
Sbjct: 401 DITVILNAVN-----AECQ-----KRQNVLLSATLTEGVTRLAD-ISLHDPVSISVLDKS 449

Query: 359 H-CIMPHVK--QTFLRLKGADKVAELV-------HILKHRDRAERTGPSGTVLVFCNSSS 408
           H  + P  K  Q        DK+           H+     +      +  +L  C    
Sbjct: 450 HDQLNPKDKAVQEVCPPPAGDKLDSFAIPESLKQHVTVVPSKLRLVCLAAFILQKCKFEE 509

Query: 409 TVNWLGYILDDHKIQ-HLRL-------------QGQMP-ALMRV---------------G 438
               + +      ++ H  L              GQ+P A MR+                
Sbjct: 510 DQKMVVFFSSCELVEFHYSLFLQTLLSSSGAPASGQLPSASMRLKFLRLHGGMEQEERTA 569

Query: 439 IFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVG 492
           +FQ F  S R +LLCTD+A+RGLD   V  +V Y+ P +  +YIHR GR  R+G
Sbjct: 570 VFQEFSHSRRGVLLCTDVAARGLDLPQVTWIVQYNAPSSPAEYIHRIGRTARIG 623


>gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo
           sapiens]
          Length = 600

 Score =  129 bits (324), Expect = 7e-30
 Identities = 113/385 (29%), Positives = 185/385 (48%), Gaps = 42/385 (10%)

Query: 124 SKGSFADLG--LEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLS 181
           ++GS+  L   L P+VL AL+E     + P  VQS+TIP  +R + V   A TGSGKTL+
Sbjct: 5   TEGSWESLPVPLHPQVLGALRELGFPYMTP--VQSATIPLFMRNKDVAAEAVTGSGKTLA 62

Query: 182 YLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGH 241
           +++P+L+ LL +   + L       +++ P+RELA Q+  V     +      + L  G 
Sbjct: 63  FVIPILEILLRRE--EKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGG 120

Query: 242 GMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLE------QLSFLVLDEADTLLDES 295
                 ++  +Q   +++VATPG L    + +   L+       L  LVLDEAD LLD  
Sbjct: 121 RNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMG 180

Query: 296 FLELVDYILEKSHIAEGPADLEDPFNPKAQLV-LVGATFPEGVGQLLNK-VASPDAVTT- 352
           F   ++ ILE              F PK +   L  AT  + V  L+   + +P  V+  
Sbjct: 181 FEASINTILE--------------FLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVK 226

Query: 353 ---ITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSST 409
              + +S        ++  ++  K  +K  +LVH L++  + +        LVF ++ + 
Sbjct: 227 EKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQEKH-------LVFFSTCAC 279

Query: 410 VNWLGYILDD--HKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVE 467
           V + G  L+     ++ + + G+M    R  IF  F+K    IL+CTD+ +RG+D   V 
Sbjct: 280 VEYYGKALEVLVKGVKIMCIHGKMK-YKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVN 338

Query: 468 LVVNYDFPPTLQDYIHRAGRVGRVG 492
            V+ YD P     ++HR GR  R+G
Sbjct: 339 WVLQYDPPSNASAFVHRCGRTARIG 363


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,894,507
Number of Sequences: 37866
Number of extensions: 1008966
Number of successful extensions: 2774
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 2533
Number of HSP's gapped (non-prelim): 135
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.