Search of human proteins with 83715985

Search of human proteins with 83715985

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
         (252 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ...   491   e-139
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...   484   e-137
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]          109   3e-24
gi|40254992 carbonic reductase 4 [Homo sapiens]                       102   4e-22
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    94   1e-19
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    75   5e-14
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 74   9e-14
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    73   2e-13
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    68   9e-12
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    62   4e-10
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     62   5e-10
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    60   2e-09
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    60   2e-09
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         59   3e-09
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    55   8e-08
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              54   1e-07
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     50   1e-06
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    50   2e-06
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...    49   3e-06
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        49   4e-06
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    48   7e-06
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         48   9e-06
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    48   9e-06
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    47   1e-05
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           47   1e-05
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     47   2e-05
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    47   2e-05
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   47   2e-05
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   46   3e-05
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    46   4e-05

>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
           [Homo sapiens]
          Length = 252

 Score =  491 bits (1265), Expect = e-139
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 1   MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
           MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
Sbjct: 1   MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60

Query: 61  APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
           APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
Sbjct: 61  APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120

Query: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
           NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
Sbjct: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180

Query: 181 PIARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGE 240
           PIARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGE
Sbjct: 181 PIARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGE 240

Query: 241 VIRLDGAIRMQP 252
           VIRLDGAIRMQP
Sbjct: 241 VIRLDGAIRMQP 252


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score =  484 bits (1245), Expect = e-137
 Identities = 252/261 (96%), Positives = 252/261 (96%), Gaps = 9/261 (3%)

Query: 1   MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
           MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
Sbjct: 1   MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60

Query: 61  APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
           APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
Sbjct: 61  APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120

Query: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
           NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
Sbjct: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180

Query: 181 PIARDLAPI---------GLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 231
           PIARDLAPI         GLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
Sbjct: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 240

Query: 232 IENPFLNGEVIRLDGAIRMQP 252
           IENPFLNGEVIRLDGAIRMQP
Sbjct: 241 IENPFLNGEVIRLDGAIRMQP 261


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score =  109 bits (272), Expect = 3e-24
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 36/266 (13%)

Query: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLG-----------N 56
           ++  +A++TG  SG+G A + RL G+GA+    DL  +  +   + LG           N
Sbjct: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68

Query: 57  NCVFAPADVTSEKDVQTALALAKGKFGRV-DVAVNCAGIAVASKTYNLKKGQTHTLEDFQ 115
           +  F  ADV+  +  +  L   +  F R   V V+CAGI       ++ +      +D+ 
Sbjct: 69  HAAFQ-ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE------DDWD 121

Query: 116 RVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGI 175
           +V+ VNL GTF V +  A  +  N     G RG IIN +S+    G VGQ  Y+ASK G+
Sbjct: 122 KVIAVNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTNYAASKAGV 176

Query: 176 VGMTLPIARDLAPIGL---------FGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAH 226
           +G+T   AR+L   G+           TP+   +P+KV + +   +P    LGDP + A 
Sbjct: 177 IGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHLGDPEDVAD 235

Query: 227 LVQ--AIIENPFLNGEVIRLDGAIRM 250
           +V   A  ++ ++ G  + + G + M
Sbjct: 236 VVAFLASEDSGYITGTSVEVTGGLFM 261


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  102 bits (253), Expect = 4e-22
 Identities = 74/248 (29%), Positives = 118/248 (47%), Gaps = 25/248 (10%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDV 71
           V  + GG+ G+G A A+ +  +G    ++     G +A A  LG + +    DV  E DV
Sbjct: 4   VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDV 63

Query: 72  QTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRL 131
           Q      +   GRV+  VN AGI   ++   L + +T   ED    L  NL+G+    + 
Sbjct: 64  QNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKT---EDMVSQLHTNLLGSMLTCKA 117

Query: 132 VAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA---- 187
               M Q       Q G I+N  S+   +G  GQ+ YSASKGG+VG +  +A+++A    
Sbjct: 118 AMRTMIQQ------QGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI 171

Query: 188 -----PIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVI 242
                  G   T +   L E+    L   +P   R G+  E AH V  ++E+P++ G V+
Sbjct: 172 RVNVVAPGFVHTDMTKDLKEE---HLKKNIPL-GRFGETIEVAHAVVFLLESPYITGHVL 227

Query: 243 RLDGAIRM 250
            +DG +++
Sbjct: 228 VVDGGLQL 235


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 93.6 bits (231), Expect = 1e-19
 Identities = 69/228 (30%), Positives = 108/228 (47%), Gaps = 27/228 (11%)

Query: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
           G V V+TGG  G+G       V  GA  V+ D   SGG A  ++L    VF   DVT E 
Sbjct: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL-PGAVFILCDVTQED 67

Query: 70  DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
           DV+T ++    +FGR+D  VN AG          ++ +  + + F+++L++NL+GT+ + 
Sbjct: 68  DVKTLVSETIRRFGRLDCVVNNAGHHPPP-----QRPEETSAQGFRQLLELNLLGTYTLT 122

Query: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI 189
           +L    + +++       G +IN +S+    GQ     Y A+KG +  MT  +A D +P 
Sbjct: 123 KLALPYLRKSQ-------GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY 175

Query: 190 GL---------FGTPLLTSL----PEKVCNFLASQVPFP-SRLGDPAE 223
           G+           TPL   L    P+         +  P  R+G PAE
Sbjct: 176 GVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAE 223


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 75.1 bits (183), Expect = 5e-14
 Identities = 70/263 (26%), Positives = 114/263 (43%), Gaps = 46/263 (17%)

Query: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
           V G VA++TG A G+G A AE L+ +GA   L+D     G      L         +F  
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
            DV  ++ ++         FGR+D+ VN AG+              +  +++++ L +NL
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
           +   +   L    M +     GG+ G+IIN +S+A       Q  Y ASK GIVG T   
Sbjct: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSA 165

Query: 183 A------------RDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEY------ 224
           A              + P G   T +L S+ EK  N +   + +   + D  +Y      
Sbjct: 166 ALAANLMNSGVRLNAICP-GFVNTAILESI-EKEEN-MGQYIEYKDHIKDMIKYYGILDP 222

Query: 225 ---AHLVQAIIENPFLNGEVIRL 244
              A+ +  +IE+  LNG ++++
Sbjct: 223 PLIANGLITLIEDDALNGAIMKI 245


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 73/253 (28%), Positives = 108/253 (42%), Gaps = 31/253 (12%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTS 67
           VA ITGG SG+G   AE  +  G   V+           A+KL    G  C+    DV +
Sbjct: 30  VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRA 89

Query: 68  EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
              V  A+  A  +FGR+D+ +NCA          L      +   F+ V+D++  GTFN
Sbjct: 90  PPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL------SFNAFKTVMDIDTSGTFN 143

Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIA---- 183
           V R++  +  +   D G   GVI+N  +     GQ  Q    ++K  +  MT  +A    
Sbjct: 144 VSRVLYEKFFR---DHG---GVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWG 197

Query: 184 ------RDLAPIGLFGTPLLTSL--PEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIE-- 233
                   LAP  + GT  L  L  P+   +   +  P   RLG+  E AH V  +    
Sbjct: 198 PQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPL-QRLGNKTEIAHSVLYLASPL 256

Query: 234 NPFLNGEVIRLDG 246
             ++ G V+  DG
Sbjct: 257 ASYVTGAVLVADG 269


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 53/177 (29%), Positives = 81/177 (45%), Gaps = 22/177 (12%)

Query: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
           V G VA++TG A G+G A AE L+ +GA   L+D     G      L         +F  
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
            DV  ++ ++         FGR+D+ VN AG+              +  +++++ L +NL
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
           +   +   L    M +     GG+ G+IIN +S+A       Q  Y ASK GIVG T
Sbjct: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFT 162


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 67.8 bits (164), Expect = 9e-12
 Identities = 59/197 (29%), Positives = 93/197 (47%), Gaps = 22/197 (11%)

Query: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKK------LGNNCVF 60
           ++ G   V+TGG+SG+G   A     QGA   L+   N     QAKK      + +  V 
Sbjct: 29  ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLV-ARNEDKLLQAKKEIEMHSINDKQVV 87

Query: 61  APADVTSEKD---VQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
               V   +D   V+  +  A+ K G VD+ VNCAG+AV+ K  +L+      +  F+R+
Sbjct: 88  LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLE------VSTFERL 141

Query: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
           + +N +G+    R V   M +       + G I+  +S A   G  G  AYSASK  I G
Sbjct: 142 MSINYLGSVYPSRAVITTMKER------RVGRIVFVSSQAGQLGLFGFTAYSASKFAIRG 195

Query: 178 MTLPIARDLAPIGLFGT 194
           +   +  ++ P  ++ T
Sbjct: 196 LAEALQMEVKPYNVYIT 212


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 17/240 (7%)

Query: 6   RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLGNNCVFAP 62
           +SV G + +ITG   G+G  T      + +  VL D+   G E   A+ +KLG       
Sbjct: 32  KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV 91

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
            D ++ +++  +L   K + G V + VN AG    +   + K       E+  +  +VN+
Sbjct: 92  VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKD------EEITKTFEVNI 145

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
           +G F + + +   M +         G I+  ASV   EG      Y +SK   VG    +
Sbjct: 146 LGHFWITKALLPSMMER------NHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGL 199

Query: 183 ARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVI 242
             +L  +G  G       P  V N   ++ P  +RL    E   +V+++I+    N ++I
Sbjct: 200 TSELQALGKTGIKTSCLCPVFV-NTGFTKNP-STRLWPVLETDEVVRSLIDGILTNKKMI 257


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 56/186 (30%), Positives = 84/186 (45%), Gaps = 27/186 (14%)

Query: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF--------- 60
           G V ++TG  +GLG A A     +GA  V+ DL   GG+ +    G+             
Sbjct: 9   GRVVLVTGAGAGLGRAYALAFAERGALVVVNDL---GGDFKGVGKGSLAADKVVEEIRRR 65

Query: 61  ---APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
              A A+  S ++ +  +  A   FGR+DV VN AGI        +        ED+  +
Sbjct: 66  GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISD------EDWDII 119

Query: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
             V+L G+F V R     M + +       G II T+S +   G  GQA YSA+K G++G
Sbjct: 120 HRVHLRGSFQVTRAAWEHMKKQK------YGRIIMTSSASGIYGNFGQANYSAAKLGLLG 173

Query: 178 MTLPIA 183
           +   +A
Sbjct: 174 LANSLA 179


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 53/182 (29%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
           VAV+TG  SG+G A A RL   GA  V+        +    KL   G +       V   
Sbjct: 38  VAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKA 97

Query: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTF 126
           +D +  +A A    G VD  V  AG+       N   G T    +  + ++L VN     
Sbjct: 98  EDREQLVAKALEHCGGVDFLVCSAGV-------NPLVGSTLGTSEQIWDKILSVN----- 145

Query: 127 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186
             ++  A  + Q  P    +RG +I  +S+AA+   V    Y+ SK  ++G+T  +A +L
Sbjct: 146 --VKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203

Query: 187 AP 188
           AP
Sbjct: 204 AP 205


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 53/182 (29%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
           VAV+TG  SG+G A A RL   GA  V+        +    KL   G +       V   
Sbjct: 38  VAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKA 97

Query: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTF 126
           +D +  +A A    G VD  V  AG+       N   G T    +  + ++L VN     
Sbjct: 98  EDREQLVAKALEHCGGVDFLVCSAGV-------NPLVGSTLGTSEQIWDKILSVN----- 145

Query: 127 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186
             ++  A  + Q  P    +RG +I  +S+AA+   V    Y+ SK  ++G+T  +A +L
Sbjct: 146 --VKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203

Query: 187 AP 188
           AP
Sbjct: 204 AP 205


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 51/202 (25%), Positives = 82/202 (40%), Gaps = 15/202 (7%)

Query: 6   RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLGNNCVFAP 62
           +SV G + +ITG   G+G  TA       +  VL D+   G E   A+ K LG       
Sbjct: 32  KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFV 91

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
            D ++ +D+ ++    K + G V + VN AG+   S  +  +  Q       ++  +VN+
Sbjct: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQ------IEKTFEVNV 145

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
           +  F   +     M +N        G I+  AS A         AY +SK   VG    +
Sbjct: 146 LAHFWTTKAFLPAMTKN------NHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTL 199

Query: 183 ARDLAPIGLFGTPLLTSLPEKV 204
             +LA + + G       P  V
Sbjct: 200 TDELAALQITGVKTTCLCPNFV 221


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 61/250 (24%), Positives = 105/250 (42%), Gaps = 26/250 (10%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
           VA++T    G+G A A RL   GA  V+        +     L   G +       V   
Sbjct: 34  VALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKA 93

Query: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
           +D +  +A A    G +D+ V+ A +     +         T E + + LD+N+     +
Sbjct: 94  EDRERLVATAVKLHGGIDILVSNAAVNPFFGSI-----MDVTEEVWDKTLDINVKAPALM 148

Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
            + V  EM +    +GG  G ++  +S+AAF    G + Y+ SK  ++G+T  +A +LAP
Sbjct: 149 TKAVVPEMEK----RGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202

Query: 189 ---------IGLFGTPLLTSL-PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII--ENPF 236
                     GL  T     L  +K       +     RLG+P + A +V  +   +  +
Sbjct: 203 RNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASY 262

Query: 237 LNGEVIRLDG 246
           + GE + + G
Sbjct: 263 ITGETVVVGG 272


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 63/236 (26%), Positives = 98/236 (41%), Gaps = 35/236 (14%)

Query: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
           G   ++TG   G+G  T + L   GA  V +    S  +A    L   C           
Sbjct: 7   GRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVDLG 62

Query: 70  DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
           D + A   A G  G VD+ VN A +A+      + K      E F R  +VNL     V 
Sbjct: 63  DWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVIQVS 115

Query: 130 RLVA-GEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
           ++VA G + +  P      G I+N +S  +       + Y ++KG +  +T  +A +L P
Sbjct: 116 QIVARGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169

Query: 189 -----IGLFGTPLLTSL-------PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 232
                  +  T ++TS+       P K    L +++P    LG  AE  H+V AI+
Sbjct: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 45/183 (24%), Positives = 80/183 (43%), Gaps = 19/183 (10%)

Query: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
           G V ++T  A G+G A A     +GA  +  D+  S  +   K  G        DVT +K
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQT--RVLDVTKKK 63

Query: 70  DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
            +         +  R+DV  N AG        + ++      +D+   +++N+   + +I
Sbjct: 64  QIDQFA----NEVERLDVLFNVAGFVHHGTVLDCEE------KDWDFSMNLNVRSMYLMI 113

Query: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAA-FEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
           +    +M         + G IIN +SVA+  +G V +  YS +K  ++G+T  +A D   
Sbjct: 114 KAFLPKM------LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167

Query: 189 IGL 191
            G+
Sbjct: 168 QGI 170


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 45/180 (25%), Positives = 79/180 (43%), Gaps = 14/180 (7%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
           VA++T    G+G A A RL    A  V+        +     L   G +       V   
Sbjct: 34  VALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKA 93

Query: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
           +D +  +A+A    G +D+ V+ A +     +         T E + + LD+N+     +
Sbjct: 94  EDRERLVAMAVKLHGGIDILVSNAAVNPFFGSL-----MDVTEEVWDKTLDINVKAPALM 148

Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
            + V  EM +    +GG  G ++  +S+AAF    G + Y+ SK  ++G+   +A +LAP
Sbjct: 149 TKAVVPEMEK----RGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 15/131 (11%)

Query: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQA----KKLGNN-CVFA 61
           +++G  AV+TG  SG+G  TA  L  +GA  VL       GEA A    ++ GNN  +F 
Sbjct: 33  NLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFM 92

Query: 62  PADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVN 121
             D+ S   V+           R+D+ ++ AGI+   +          T E F  +L VN
Sbjct: 93  ALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGR----------TREAFNLLLRVN 142

Query: 122 LMGTFNVIRLV 132
            +G F +  L+
Sbjct: 143 HIGPFLLTHLL 153


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 64/261 (24%), Positives = 96/261 (36%), Gaps = 36/261 (13%)

Query: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVL----LDLPNSGGEAQAKKLGNNCVFAP 62
           S +G VA ITGG +GLG      L   GA  V+    +D+  +  E  + + GN      
Sbjct: 56  SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDF-------- 114
            DV     VQ  ++      G  ++ +N A     S T  L      T+ D         
Sbjct: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 175

Query: 115 -----QRVLDVNLMGTFNVIRLVAGEMGQN--EPDQGGQRGVIINTASVAAFEGQVGQAA 167
                ++++       F  I  +  E G     P    + GV   + S+AA  G+ G   
Sbjct: 176 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 235

Query: 168 YSASKGGIVGMTLPIARDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHL 227
                G I   T      L P G F   ++  +P   C           RLG   E A+L
Sbjct: 236 NVIQPGPI--KTKGAFSRLDPTGTFEKEMIGRIP---C----------GRLGTVEELANL 280

Query: 228 VQAIIEN--PFLNGEVIRLDG 246
              +  +   ++NG VI+ DG
Sbjct: 281 AAFLCSDYASWINGAVIKFDG 301


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 48.1 bits (113), Expect = 7e-06
 Identities = 59/207 (28%), Positives = 87/207 (42%), Gaps = 28/207 (13%)

Query: 12  VAVITGGASGLGLATAERLVGQGAS-----AVLLDLPNSGGEAQAKKL----GNNCVFAP 62
           V +ITG +SG+GL  A RL    +      A L DL   G   +A +       +     
Sbjct: 5   VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64

Query: 63  ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
            DV   K V  A A  +   GRVDV V  AG+ +      L +      +    VLDVN+
Sbjct: 65  LDVRDSKSV--AAARERVTEGRVDVLVCNAGLGLLGPLEALGE------DAVASVLDVNV 116

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
           +GT  +++    +M +         G ++ T SV    G      Y ASK  + G+   +
Sbjct: 117 VGTVRMLQAFLPDMKRR------GSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESL 170

Query: 183 ARDLAPIGLFGT-----PLLTSLPEKV 204
           A  L P G+  +     P+ T+  EKV
Sbjct: 171 AVLLLPFGVHLSLIECGPVHTAFMEKV 197


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 50/203 (24%), Positives = 86/203 (42%), Gaps = 32/203 (15%)

Query: 7   SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAK-----KLGNNCVFA 61
           ++ G   ++TG  +G+G  TA  L  +G + +L        EA AK      L ++    
Sbjct: 35  TIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNAR 94

Query: 62  PADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVN 121
             D+ S K ++   A    +  RVD+ +N AG+        ++     T + F+    VN
Sbjct: 95  HLDLASLKSIREFAAKIIEEEERVDILINNAGV--------MRCPHWTTEDGFEMQFGVN 146

Query: 122 LMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVG-------------QAAY 168
            +G F +  L+  ++  + P +      IIN +S+A   G +              +AAY
Sbjct: 147 HLGHFLLTNLLLDKLKASAPSR------IINLSSLAHVAGHIDFDDLNWQTRKYNTKAAY 200

Query: 169 SASKGGIVGMTLPIARDLAPIGL 191
             SK  IV  T  ++R L   G+
Sbjct: 201 CQSKLAIVLFTKELSRRLQGSGV 223


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 52/186 (27%), Positives = 79/186 (42%), Gaps = 23/186 (12%)

Query: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
           VA++T     +G A A+RL   GA  V+        +     L   G +       V   
Sbjct: 34  VALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKM 93

Query: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQ-----THTLED-FQRVLDVNL 122
           KD +  +A A    G +D+        ++    N K+G        T E+ + R LD+N 
Sbjct: 94  KDWERLVATAMKLHGVIDI--------LSLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145

Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
                +I+ V  EM   E   GG  G +   ASVAAF    G + Y+ SK  ++G+   +
Sbjct: 146 KALALMIKAVVPEM---EKRGGGSVGFL---ASVAAFRPLPGFSPYNVSKTALLGLNKTL 199

Query: 183 ARDLAP 188
           A +LAP
Sbjct: 200 AIELAP 205


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 56/184 (30%), Positives = 76/184 (41%), Gaps = 25/184 (13%)

Query: 15  ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
           ITG  SG G   A +L  +G   +   L  SG E   +   +       D+T  + VQ A
Sbjct: 33  ITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQA 92

Query: 75  LALAK------GKFGRVDVAVNCAGIA-VASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
               +      G FG     VN AG+A +   T  L      T +DFQRVL+VN MG   
Sbjct: 93  AKWVEMHVKEAGLFG----LVNNAGVAGIIGPTPWL------TRDDFQRVLNVNTMGPIG 142

Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
           V   +   + Q        RG +IN  SV       G   Y  SK G+   +  + RD+A
Sbjct: 143 VTLALLPLLQQ-------ARGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDVA 194

Query: 188 PIGL 191
             G+
Sbjct: 195 HFGI 198


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 47/176 (26%), Positives = 70/176 (39%), Gaps = 16/176 (9%)

Query: 6   RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLGNNCVFA- 61
           ++V G + +ITG  SGLG   A +    G+  VL D+   G E     A++ G   V A 
Sbjct: 36  KNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAY 95

Query: 62  PADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVN 121
             D + ++ V       K + G V + +N AGI    K  +         E  ++  DVN
Sbjct: 96  TCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPD------ELMEKSFDVN 149

Query: 122 LMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
                   +     M  N+       G ++  +S A   G  G A Y ASK    G
Sbjct: 150 FKAHLWTYKAFLPAMIAND------HGHLVCISSSAGLSGVNGLADYCASKFAAFG 199


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 21/192 (10%)

Query: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLD-----LPNSGGEAQAK---KLGNNCV 59
           ++G VA++TGGA+G+G A  + L+  G++ V+       L ++  E QA          +
Sbjct: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75

Query: 60  FAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLD 119
               ++ +E++V   +      FG+++  VN  G    S   ++     H       VL+
Sbjct: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA------VLE 129

Query: 120 VNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
            NL GTF + + V     +   + GG   V I   + A F   V      A++ G+  +T
Sbjct: 130 TNLTGTFYMCKAVYSSWMK---EHGGSI-VNIIVPTKAGFPLAVHS---GAARAGVYNLT 182

Query: 180 LPIARDLAPIGL 191
             +A + A  G+
Sbjct: 183 KSLALEWACSGI 194


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 15/179 (8%)

Query: 15  ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
           ITG  SG G   A++LV +G   +       G +   +           DVT  + ++ A
Sbjct: 30  ITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAA 89

Query: 75  LALAKGKFGRVDV--AVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLV 132
               + K G   +   VN AG+ + S        +  T +DF +V++VNL+G   V   +
Sbjct: 90  AQWVRDKVGEQGLWALVNNAGVGLPS-----GPNEWLTKDDFVKVINVNLVGLIEVTLHM 144

Query: 133 AGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGL 191
                   P     RG ++N +S       +G   Y  SK G+   +  I R+L   G+
Sbjct: 145 L-------PMVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELYYFGV 195


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 50/183 (27%), Positives = 74/183 (40%), Gaps = 23/183 (12%)

Query: 15  ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
           ITG  SG G   A +L  +G   +   L   G E    +  +       DVT  + V  A
Sbjct: 34  ITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAA 93

Query: 75  LALA------KGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
                     KG +G     VN AGI++ +    L      T +DF  +LDVNL+G  +V
Sbjct: 94  AQWVKECVRDKGLWG----LVNNAGISLPTAPNELL-----TKQDFVTILDVNLLGVIDV 144

Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
              +        P     RG ++N +SV       G   Y  SK G+   +  + R+L+ 
Sbjct: 145 TLSLL-------PLVRRARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSY 196

Query: 189 IGL 191
            G+
Sbjct: 197 FGV 199


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 53/202 (26%), Positives = 90/202 (44%), Gaps = 37/202 (18%)

Query: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFA-PAD 64
           G V V+TG  +G+G  TA+ L  +GA   L       GE  AK++    GN  V     D
Sbjct: 41  GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100

Query: 65  VTSEKDVQTALALAKGKFG---RVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVN 121
           ++  K ++   A AKG       + V +N AG+ +           + T + F+  + VN
Sbjct: 101 LSDTKSIR---AFAKGFLAEEKHLHVLINNAGVMMCP--------YSKTADGFEMHIGVN 149

Query: 122 LMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQV------GQAAYSA----- 170
            +G F +  L+  ++ ++ P +      I+N +S+A   G++      G+  Y+A     
Sbjct: 150 HLGHFLLTHLLLEKLKESAPSR------IVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYC 203

Query: 171 -SKGGIVGMTLPIARDLAPIGL 191
            SK   +  T  +AR L   G+
Sbjct: 204 HSKLANILFTQELARRLKGSGV 225


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 50/184 (27%), Positives = 75/184 (40%), Gaps = 25/184 (13%)

Query: 15  ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
           ITG  SG G   A     +G   +   L  SG  A   +          DVT  ++V+  
Sbjct: 34  ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93

Query: 75  LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
               K + G   +   +N AG+  V + T  L      TLED++  ++VNL G    T N
Sbjct: 94  AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147

Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
           ++ LV    G+           +IN +SV      VG   Y+ SK  + G    + RD+ 
Sbjct: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195

Query: 188 PIGL 191
             G+
Sbjct: 196 AFGV 199


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,795,195
Number of Sequences: 37866
Number of extensions: 380264
Number of successful extensions: 834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 752
Number of HSP's gapped (non-prelim): 80
length of query: 252
length of database: 18,247,518
effective HSP length: 100
effective length of query: 152
effective length of database: 14,460,918
effective search space: 2198059536
effective search space used: 2198059536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.