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Search of human proteins with 81295816
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
(551 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 1050 0.0
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 130 2e-30
gi|148746195 trichohyalin [Homo sapiens] 130 3e-30
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 125 8e-29
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 123 5e-28
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 120 4e-27
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 117 3e-26
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 112 1e-24
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 108 1e-23
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 108 1e-23
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 102 1e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 101 2e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 101 2e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 101 2e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 101 2e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 101 2e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 101 2e-21
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 101 2e-21
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 101 2e-21
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 98 2e-20
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 95 2e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 94 4e-19
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 93 6e-19
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 93 7e-19
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 93 7e-19
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 93 7e-19
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 93 7e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 92 2e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 91 4e-18
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 91 4e-18
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 1050 bits (2715), Expect = 0.0
Identities = 551/551 (100%), Positives = 551/551 (100%)
Query: 1 MPLSTAGILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDK 60
MPLSTAGILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDK
Sbjct: 1 MPLSTAGILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDK 60
Query: 61 HTLQKTLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLT 120
HTLQKTLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLT
Sbjct: 61 HTLQKTLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLT 120
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA 180
REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA
Sbjct: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA 180
Query: 181 NKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSI 240
NKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSI
Sbjct: 181 NKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSI 240
Query: 241 QRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKD 300
QRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKD
Sbjct: 241 QRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKD 300
Query: 301 MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER 360
MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER
Sbjct: 301 MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER 360
Query: 361 IRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAEL 420
IRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAEL
Sbjct: 361 IRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAEL 420
Query: 421 RKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRR 480
RKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRR
Sbjct: 421 RKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRR 480
Query: 481 QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER 540
QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER
Sbjct: 481 QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER 540
Query: 541 KANILPATSVN 551
KANILPATSVN
Sbjct: 541 KANILPATSVN 551
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 130 bits (328), Expect = 2e-30
Identities = 110/455 (24%), Positives = 229/455 (50%), Gaps = 66/455 (14%)
Query: 146 KKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHA 205
KKI KQ+E +W ++L + E +E+ + + ++ +LR EQE+EL++ K + K
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR-EQEKELREQEKELREQK--K 304
Query: 206 IRDAQILEKQQIQKELDTEEKRLDQMMEV--------ERQKSIQRQEELER--------- 248
+R+ + ++Q +K + EEK +Q ++ E++K ++ QE+ R
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364
Query: 249 ----KRREERIRGRRQIVEQMEKNQEERSLLAEQRE--QEKEQMLEYME--QLQEEDLKD 300
+ +EER+R + ++ EQ EK QEE + +++ +E+E M E E Q QEE++ +
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 301 MERR--QQQKLKMQAEIKRINDENQKQKAELLAQ-EKLADQMVMEFTKKKMAREAEFEAE 357
E + QQQ+L Q E ++ Q+Q+ ++ Q EK+ DQ M +KKM R+ + +
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 358 QERIRREKEK-----------------EIARLRAMQEKAQD----YQAEQDALRAKRNQE 396
++++ ++EK + RLR +E+ ++ +Q E+ K+ QE
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 397 VADREWRRKEK-------ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERI 449
+ W ++EK KKM E E+ + + E++ +E + Q ++ ++ E++
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM 604
Query: 450 LRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQK 509
+ + E+E E++ ++Q E+ + E Q++ + +E+ +++E+ +K
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK---MWEQEEKMREQEEK 661
Query: 510 RRERIDEI----KRKKLEELRATGLPEKYCIEAER 540
RE+ +++ ++ + +E + G EK + E+
Sbjct: 662 MREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEK 696
Score = 120 bits (301), Expect = 3e-27
Identities = 114/474 (24%), Positives = 243/474 (51%), Gaps = 59/474 (12%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLE 166
E+ E+++ L +E E R+Q +KE +++ +Q+E +W +K+ + E
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQ--EKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330
Query: 167 EVAKERAQNLLQRANKLRMEQEEELKDMSKII------LNAKCHAIRDAQIL----EKQQ 216
E + + L ++ ++R EQE++++D + + L K +R+ + + EK Q
Sbjct: 331 EKMWRQEERLWEQEKQMR-EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQ 389
Query: 217 IQKELDTEEKRLDQMMEV--ERQKSIQRQEEL-----ERKRREERIRGRRQIVEQMEKNQ 269
++ + EK++ + E E+++ +Q+QEE E++ +++R+ +++ + + EK Q
Sbjct: 390 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 449
Query: 270 EERSLLAEQRE----------QEK-----EQMLEYMEQL--QEEDLKDMERR---QQQKL 309
E+ + EQ E QEK E+M E +Q+ QEE ++D E++ Q++++
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 509
Query: 310 KMQAEIKRINDENQKQKAELLAQE-KLADQMVMEFTKKKMAREAEFEAEQERIRREKEK- 367
Q E R +E +++ ++ QE K+ ++ + +KK + E E+ER+R ++K
Sbjct: 510 WEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM 569
Query: 368 --EIARLRAMQEKAQDY------QAEQDALRAKRNQEVADREWRRKEK---ENARKKMET 416
E +R +EK Q+ Q E+ + ++ QE ++ W ++EK + KM+
Sbjct: 570 REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Query: 417 EAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQI---EKERLEEEKKATGRLQ 473
+ E+ + E++ +E + Q ++ R++ E+ +R Q E++ E++ E+E+K G+ +
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK-MREQEEKMQGQEEKMREQEEKMQGQEE 688
Query: 474 HANELRRQVRENQQK--EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEEL 525
E ++R ++K + ++ EE +EE +++ ERI + K K E L
Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERL 742
Score = 111 bits (277), Expect = 2e-24
Identities = 104/472 (22%), Positives = 226/472 (47%), Gaps = 68/472 (14%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTR------------KKIMKQKEMVWN 157
+R++ L +E E R+Q +E+E M + +K+ +Q+E +W
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLR------------------MEQEEELKDMSKIIL 199
K++ + E+ +++ + + ++ +LR M++EE +++ K +
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402
Query: 200 NAKCHAIRDAQILEKQQI----QKELDTEEKRLDQMME-VERQKSIQRQEEL-----ERK 249
+ + ++KQ+ Q+E + +++RL + E + Q+ +Q QEE E+
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 250 RREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQ---MLEYMEQLQEED--LKDMERR 304
R +E + G+ + + + EK +E+ + EQ E+ ++Q M + E++ E+D L++ E R
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER 522
Query: 305 QQQKLKMQAEIKRINDENQKQKAELLA---QEKLADQMVMEFTKKKMAREAEFEAEQE-- 359
+++ KM + +++ +E + Q+ E +EK+ ++ M +KKM E E EQE
Sbjct: 523 MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582
Query: 360 ------RIRREKEKEIARLRAMQEKAQDYQAEQDAL----RAKRNQEVADREWRRKEK-- 407
++R ++EK + MQE+ + +++ + + QE + W ++EK
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642
Query: 408 ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQ---REQIEKERLEE 464
E K E E ++R+ E++ +E + Q ++ R++ E++ + REQ EK R +E
Sbjct: 643 EQEEKMWEQEEKMREQE-EKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Query: 465 EKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDE 516
EK + + + + + +E + RI ++ +++E + ER E
Sbjct: 702 EKMWGQEEKMWGQEEKMWGQEEMREKEERIR--DQKEKMQERLPEHEERCSE 751
Score = 108 bits (270), Expect = 1e-23
Identities = 108/410 (26%), Positives = 200/410 (48%), Gaps = 49/410 (11%)
Query: 171 ERAQNLLQRA--NKLRME---QEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEE 225
ERA+ LL + N L+ E QEEEL++ K I + R + L +Q E
Sbjct: 218 ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ--------EG 269
Query: 226 KRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQ 285
K +Q ++ RQ+ R++E E + +E+ +R ++++ EQ E+ QE+ + EQ E+ +EQ
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 286 MLEYMEQLQEEDLKDME---RRQQQKLKMQAEIKRINDENQKQKAELL--------AQEK 334
E QEE L + E R Q+QK++ Q E DE ++K E + +EK
Sbjct: 330 --EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 335 LADQMVMEFTKKKMAREAEFEAEQER----------IRREKEKEIARLRAMQEK--AQDY 382
+ ++ + +KKM E E EQE + EKE + RL +EK Q+
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 447
Query: 383 QAEQDALRAKRNQEVADRE---------WRRKEKENARKKMETEAELRKSRLEQVAFKEH 433
EQ+ ++ +++ D+E WR+++ +M + E + + +++ +E
Sbjct: 448 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 507
Query: 434 ALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQ-KEVQN 492
+ Q +R R++ ER+ ++ ++E++ EEKK + + + ++RE ++ +E +
Sbjct: 508 RMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK 567
Query: 493 RIATFEEGRRLKEE-AQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
++ EE R +EE Q++ E++ E + K E+ E+ E E K
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Score = 107 bits (266), Expect = 4e-23
Identities = 101/444 (22%), Positives = 230/444 (51%), Gaps = 51/444 (11%)
Query: 117 HVLTREELEARDQ--------AFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEV 168
+ +T EEL+ ++ A ++ E ++ ++K+ + K ++ + + L+E
Sbjct: 178 NTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL--PQVQTNTLQEE 235
Query: 169 AKERAQNLLQRANKLRME------QEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELD 222
+ + L ++ K+R + QEE L++ + + R + L +Q +KEL
Sbjct: 236 MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ--EKELR 293
Query: 223 TEEKRL----------DQMMEVE----RQKSIQRQEELERKRREERI-RGRRQIVEQMEK 267
+EK L +QM E E Q+ R++E + R+EER+ +Q+ EQ +K
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353
Query: 268 --NQEERSLLAEQREQEKEQMLEYMEQL--QEEDLKDMERRQQQKLKMQAEIKRINDENQ 323
+QEER ++R +EKE+ + E++ QEE +++ ER ++++ KM+ E + + ++ +
Sbjct: 354 MRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413
Query: 324 KQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQ 383
K + + +E + +Q E+ ++++ + E EQE+++ ++EK + ++++ + +
Sbjct: 414 KMQKQ---EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 384 AEQDALRAKRNQEVADREWRRKEK-ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRD 442
E+ R ++ +E D+ W ++EK + +KM + E + E++ KE +R
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE-------ERM 523
Query: 443 RDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRR 502
R++ + + ++ + EK+ E+EKK + + E R +RE ++K + E+ +
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEER-MREREKKMREEEEMMREQEEK 582
Query: 503 LKEEAQKRRERIDEI--KRKKLEE 524
++E+ +K RE+ +++ + +K++E
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQE 606
Score = 98.6 bits (244), Expect = 1e-20
Identities = 69/329 (20%), Positives = 170/329 (51%), Gaps = 27/329 (8%)
Query: 106 PEEFERIKWASHVLTREELEARDQAFKKEKEATM----DAVMTRKKIMKQKEMVWNNNKK 161
PE+ E++ W + +E + +Q K + M + ++K+ +Q++ +W +K
Sbjct: 436 PEQKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 494
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKEL 221
+ D E+ ++ + + ++ +LR E+EE +++ K+ + +R+ + ++Q+ +K
Sbjct: 495 MRDQEQKMWDQEERMWEQDERLR-EKEERMREQKKMWQQEE--KMREEKKTQEQE-KKTW 550
Query: 222 DTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQ 281
D EEK ++ ER+K ++ +EE+ R++ E+ ++ EQ EK E+ + EQ E+
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 282 EKEQMLEYMEQLQEEDLKDMERRQ-QQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV 340
EQ + EQ +E+ +++ E +Q+ KMQ + +++ ++ +K + + +EK+ +Q
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ---EEKMREQ-- 665
Query: 341 MEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR 400
E + + ++E++R ++EK + M+E+ + + +++ + + +
Sbjct: 666 ----------EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQE 715
Query: 401 E--WRRKEKENARKKMETEAELRKSRLEQ 427
E W ++E +++ + E + RL +
Sbjct: 716 EKMWGQEEMREKEERIRDQKEKMQERLPE 744
Score = 97.8 bits (242), Expect = 2e-20
Identities = 84/370 (22%), Positives = 196/370 (52%), Gaps = 37/370 (10%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLE 166
+E + K ++ +EE E + Q ++KE + ++K+ +Q+E +W +K+ D E
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE----QEKMQEQEEKIWEQEEKIRDQE 466
Query: 167 EVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEK 226
E+ + + + R K+R EQE+++ + + +RD + Q ++ + +E+
Sbjct: 467 EMWGQEKK--MWRQEKMR-EQEDQMWEQEE--------KMRDQEQKMWDQEERMWEQDER 515
Query: 227 RLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQM 286
++ + QK + +QEE R+ ++ + + ++ ++ + +EER E++ +E+E+M
Sbjct: 516 LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 575
Query: 287 LEYME---QLQEEDLKDMERRQ-QQKLKMQAEIKRINDENQK---QKAELLAQEKLADQM 339
+ E Q QEE +++ E + +Q+ KMQ + +++ ++ +K Q+ E QE+ ++M
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ--EEM 633
Query: 340 VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVAD 399
+ E +K +E + ++E++R ++EK M+E+ + Q +++ +R + +
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEK-------MREQEEKMQGQEEKMREQEEKMQGQ 686
Query: 400 REWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEK 459
E R+++E KM + E + E++ +E + Q + R++ ERI R Q+E++++
Sbjct: 687 EEKMREQEE----KMRGQEEKMWGQEEKMWGQEEKMWGQ-EEMREKEERI-RDQKEKMQE 740
Query: 460 ERLEEEKKAT 469
E E++ +
Sbjct: 741 RLPEHEERCS 750
Score = 69.3 bits (168), Expect = 9e-12
Identities = 80/407 (19%), Positives = 183/407 (44%), Gaps = 80/407 (19%)
Query: 203 CHAIRD---AQILEKQQIQKELDTEEK--RLDQMMEVERQKSIQRQEELERKRREERIRG 257
CH+ D A ++ +++E++ ++ R+ + E + ++ ++ RK + +
Sbjct: 66 CHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGE 125
Query: 258 RRQIVEQMEKN-----QEERSLLA------------EQREQEKEQM-LE-YMEQLQEEDL 298
+ + ++ + + +R+L A E+ +E++ + LE Y + E+L
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 299 KDMERRQQQKLKM---------------------------QAEIKRINDENQKQKAELLA 331
K Q+KL++ Q + + +E +Q+ EL
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245
Query: 332 QEK---------------LADQM-VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAM 375
QEK L +Q M ++KM R+ + EQE+ RE+EKE+ + +
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305
Query: 376 QEKAQDYQAEQDAL--RAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEH 433
+E+ + Q +++ + + ++ +E ++ WR++E+ ++K E E +++ +E
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE------QKMRDQEE 359
Query: 434 ALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNR 493
+ Q +R R++ ER+ ++ ++E+++EE++ R + E +RE ++K +
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ- 418
Query: 494 IATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER 540
EE +EE + +++R+ E K K E+ + EK + E+
Sbjct: 419 ----EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 130 bits (327), Expect = 3e-30
Identities = 117/499 (23%), Positives = 257/499 (51%), Gaps = 61/499 (12%)
Query: 74 RKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKK 133
RK ET+ + ++E E+P + + EE R L R+EL Q ++
Sbjct: 247 RKRETVLRKEEEKLQE-----EEPQRQRELQEEEEQLR------KLERQELRRERQEEEQ 295
Query: 134 EKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANK------LRMEQ 187
+++ R+K +++ ++ + E +ER + L+R + LR EQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 188 EEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELE 247
EEE ++ + + R+ Q+ +QQ+++E ++L + ++ R++ ++R+++L
Sbjct: 356 EEERREQQ--LRREQEEERREQQLRREQQLRRE-----QQLRREQQLRREQQLRREQQLR 408
Query: 248 RK---RREERIRGRRQIVEQMEKNQEERSLLAEQREQ----EKEQMLEYMEQLQEEDLKD 300
R+ RRE+++R +Q+ + E+ + E+ E+REQ E+E+ +++++ +E + +
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 301 MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER 360
ERR+QQ +KR +E ++++ L +E+ +Q E ++++ RE E EQ
Sbjct: 469 QERRKQQ-------LKRDQEEERRERWLKLEEEERREQ--QERREQQLRREQEERREQRL 519
Query: 361 IRREKEKEI-ARLRAMQEKAQDYQAEQDAL-----RAKRNQEVADREWRRKEKENARKKM 414
R+E+E+ + RLR+ Q+ ++ + ++ L + QE ++ +R+++E + +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 415 ETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQR--EQIEKERLEEEKKATGRL 472
+ E E R+ RL+ +E ++ + R+E ER+ + +R +++++E EEE++
Sbjct: 580 KREEERRQQRLK----REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 473 QHANELRR--QVRENQQKEVQNRIATFEEGRRLKE------EAQKRRERIDEIKRKKLEE 524
E RR Q+R QQ+ + R+ EE RL++ E ++R + + E ++++ E
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 525 LRATGLPE-KYCIEAERKA 542
+ +P+ ++ +E+E A
Sbjct: 696 RIKSRIPKWQWQLESEADA 714
Score = 129 bits (324), Expect = 7e-30
Identities = 105/423 (24%), Positives = 231/423 (54%), Gaps = 38/423 (8%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA 180
R+E + R++ +E++ ++ ++++ ++L +L +E Q +R
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL---RRRELLELRRKGREEKQQQ-RRE 232
Query: 181 NKLRMEQEEELKDMSK--IILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+ R+ QEEE K+ K +L + +++ E+ Q Q+EL EE++L ++ E ++
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQE----EEPQRQRELQEEEEQLRKLERQELRR 288
Query: 239 SIQRQEELERK-RREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEED 297
Q +E+ +++ RRE+++R +++ E+ + QEER E+REQ++E+ + + + QEE
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQE--EERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 298 LKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAE 357
+ RR+Q++ + + +++R +E ++++ Q+ +Q + ++++ RE + E
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR--EQQLRREQQLRRE 404
Query: 358 Q-----ERIRRE----KEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE 408
Q +++RRE +E+++ R + + Q ++ E+ R KR QE R+W ++E+E
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE-ERRDWLKREEE 463
Query: 409 NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFER---ILRAQREQIEKERL--- 462
R + E + K R ++ +E L ++ + R++ ER LR ++E+ ++RL
Sbjct: 464 TERHEQERRKQQLK-RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 463 EEEKKATGRLQHANELRRQVRENQQ----KEVQNRIATFEEGRRLKEEAQKRRERIDEIK 518
EEE++ RL+ +LRR+ E ++ +E + R+ +RLK E ++RR+++ +K
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL--LK 580
Query: 519 RKK 521
R++
Sbjct: 581 REE 583
Score = 126 bits (317), Expect = 5e-29
Identities = 117/478 (24%), Positives = 230/478 (48%), Gaps = 50/478 (10%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLE 166
EE +R + +E + R++ +++E + K+ +++E + +KKL E
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 167 E-VAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIR----DAQILEKQQIQKE- 220
E + E + ++ + + +EEEL+ + +L + R + Q +K ++Q+E
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 221 --LDTEEKRLDQMMEVERQ--KSIQRQEELERKRREERIRGRRQIVEQM-----EKNQEE 271
L EE+ ++ E ERQ + + Q+E E+ EER RRQ +E+ E QEE
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 272 RSLLAEQ----REQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKA 327
LL E+ R QE+E+ E+LQ+E+ + + ++++ + + E + +E +Q+
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 328 ELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQD 387
E L +E+ + E +++ E E + E+E++ RE+++ + QE+ + Y+ E++
Sbjct: 1151 EQLLREEPEKRRRQEL-ERQYREEEELQQEEEQLLREEQE-----KRRQERERQYREEEE 1204
Query: 388 ALRAKRNQEVADREWR-------RKEKENARKKMETEAELRKS----RLEQVAFKE---- 432
R KR Q D + R EKENA + + + R++ +LE ++
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264
Query: 433 ----HALAVQVQRDRDEFERILRA------QREQIEKERLEEEKKATGRLQHANELRRQV 482
H L Q +RDR++ R + + EQ+E+E +E K+ + Q +L R+
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Query: 483 RENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER 540
RE +++ + EE + L+E ++ R + ++ + EELR K+ E +R
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Score = 119 bits (297), Expect = 9e-27
Identities = 107/416 (25%), Positives = 213/416 (51%), Gaps = 46/416 (11%)
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQ 178
L+R+E RD+ F++E++ RK + +++++ ++K + E++ +ER + L
Sbjct: 1423 LSRQE---RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 179 RANKLR--MEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVER 236
R + R +E+E++L+ RD + E++ +E E K L++ ++ R
Sbjct: 1480 RQERDRKFLEEEQQLRRQE-----------RDRKFREQELRSQE--PERKFLEEEQQLHR 1526
Query: 237 Q----KSIQRQEELERK-----RREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287
Q K +Q +++L R+ RR++R R R+ EQ+ + +EE+ L ++R++ K ++
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLSRQERDR-KFRLE 1584
Query: 288 EYMEQLQEEDLKDMERRQQ-QKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKK 346
E + QE++ K ME QQ ++ + Q ++++ D ++ +LL QE+ Q+ + +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL-QEREEQQLHRQERDR 1643
Query: 347 KMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQ--AEQDALRAKRNQEVADREWRR 404
K E E + R RE++ R R +E+ Q Q EQ R +R+++ + E +
Sbjct: 1644 KFLEE---EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 405 KEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQ----RDRDEFERILRAQREQIEKE 460
+ +E RK ++ E +LR+ LE+ +E L + + R ++ + +IL ++ + E+E
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 461 RLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDE 516
+ ++ R E RQ RE QQ Q E R+ +EE Q R+ER ++
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQ------ESDRKFREEEQLRQEREEQ 1810
Score = 118 bits (296), Expect = 1e-26
Identities = 112/417 (26%), Positives = 208/417 (49%), Gaps = 46/417 (11%)
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVA----KERAQ 174
L EE + R+Q F E+E R++ +++E K+L LEE +ERAQ
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQ----RRRQRRERE------KELQFLEEEEQLQRRERAQ 847
Query: 175 NLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEV 234
L + + L+ +QE + + + + K E+ R +Q +
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 235 ERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE----QEKEQMLEYM 290
E ++ +QR+E +R+R+E+ RQ E+ + QEE LL E+RE QE+E+
Sbjct: 908 EEEEELQREEREKRRRQEQE----RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 291 EQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAR 350
++LQ+++ + + +++ + + E K +E +Q+ E L +E+ + E+ ++ +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 351 EAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENA 410
+ + E++ +R E+EK R +QE+ + Y+ E++ + + +RE RR+++
Sbjct: 1024 DELQQEEEQLLREEREK-----RRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 411 RKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKAT 469
+ + E E + + EQ+ +E +R R E ER R + E Q E+E+L E++
Sbjct: 1079 QYRKEEELQQEE---EQLLREE-----PEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 470 GRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q EL RQ RE ++EVQ EE + L+EE +KRR + E + ++ EEL+
Sbjct: 1131 RRRQ---ELERQYRE--EEEVQQ-----EEEQLLREEPEKRRRQELERQYREEEELQ 1177
Score = 117 bits (294), Expect = 2e-26
Identities = 106/453 (23%), Positives = 222/453 (49%), Gaps = 52/453 (11%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSD-LEEVAKERAQNLLQR 179
R E E R+Q K+E+E D ++ R++ +Q+ + ++L L+ ER + +R
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 180 ANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKEL----DTEEKRLDQMMEVE 235
+L+ E+ EE + +++ + + R Q+ +QQ ++E + EE+RL+Q ++ E
Sbjct: 617 EQRLKREEPEEER-RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 236 RQKSIQRQE--ELERKRREERIRGRR-----QIVEQMEKNQEE-----RSLLAEQREQEK 283
++ + QE E E+++ ERI+ R Q+ + + Q + R ++R QE+
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 284 EQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIK---RINDENQKQKAELLAQEKLADQMV 340
E+ E + ++ RQQQ+ + + + + +++++ + L A+ L +Q
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 341 MEF-TKKKMAREAEFEAEQE------RIRREKEKEIARLRAMQ-----EKAQDYQAEQDA 388
+ +++ RE F E+E R RRE+EKE+ L + E+AQ Q E+D
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 389 LRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFER 448
L+ D+E RR +++ +K + E + R + + AL Q++++ ++
Sbjct: 856 LQE-------DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE----QQ 904
Query: 449 ILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQ 508
+L+ + E++++E E+ ++ E RQ RE +Q + + EE + + + +
Sbjct: 905 LLQEEEEELQREEREKRRR--------QEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 509 KRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
+R+ R D+ ++K E+L ++ E E+K
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Score = 117 bits (292), Expect = 4e-26
Identities = 128/538 (23%), Positives = 246/538 (45%), Gaps = 40/538 (7%)
Query: 18 RSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLTALGLDRKPE 77
R + +YR + + +E L + + + Q + +DK QK LG +PE
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQ-ERERQYRKDKKLQQKEEQLLG--EEPE 979
Query: 78 TIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEA 137
+ R+ + + L E+ R +W ++EL+ ++ +E E
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE-ER 1038
Query: 138 TMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDM 194
+ R++ +++E + ++L E + R + Q + ++QEEE ++
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 195 SKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREER 254
K + R+ + L++++ Q + EKR Q +E + ++ + Q+E E+ REE
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 255 IRGRRQIVEQM-----EKNQEERSLLAEQRE---QEKEQMLEYMEQLQEEDLKDMERRQQ 306
+ RRQ +E+ E QEE LL E++E QE+E+ E+LQ + K R +
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 307 QK--LKMQAEIKRIN---------DENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFE 355
Q+ LK Q E ++ N + ++ L +L D+ + + + + E +
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278
Query: 356 AEQERIRREK-------EKEIARLRAMQEKAQDY--QAEQDALRAKRNQEVADREWRRKE 406
EQER R ++ E+++ R + K +D Q E+ LR +R ++ +E RK
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 407 KENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEK 466
+E + E E + + + F+E L Q ++ R E R +R++ E++ L+EE+
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQ-EQGRKFLEEEQRLRRQERERKFLKEEQ 1397
Query: 467 KATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
+ R Q + RQ R+ + +E + +++ E R+ +EE Q+ R + E +RK LEE
Sbjct: 1398 QL--RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ--ERERKFLEE 1451
Score = 115 bits (289), Expect = 8e-26
Identities = 128/450 (28%), Positives = 233/450 (51%), Gaps = 50/450 (11%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVA 169
ER + L EE + + + ++E+E + + ++ ++++E ++ L+E
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLEEEEQLQRRERAQQLQEEEDGLQEDQ 860
Query: 170 KERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQ---KELDTEEK 226
+ R +R K R + EEE K + L AK A+++ E+Q +Q +EL EE+
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERK-RRRHTLYAK-PALQEQLRKEQQLLQEEEEELQREER 918
Query: 227 RLDQMMEVERQ--KSIQRQEELERKRREERIRGRRQIVEQMEK-----NQEERSLLAEQ- 278
+ E ERQ + Q Q+E E+ REER + RRQ E+ + Q+E LL E+
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 279 ---REQEKEQMLEYMEQLQEED----LKDMERRQQQKLKMQAEIKRINDENQKQKAELLA 331
R QE+E+ E+LQ+E+ ++ E+R++Q+ + Q R DE Q+++ +LL
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ---YRKKDELQQEEEQLLR 1035
Query: 332 QEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRA 391
+E+ ++ ++ +++ E E + E+E++ E+ + R QE + Y+ E++ L+
Sbjct: 1036 EER--EKRRLQERERQYREEEELQQEEEQLLGEERE----TRRRQELERQYRKEEE-LQQ 1088
Query: 392 KRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILR 451
+ Q + + +R+ +E R+ E E EL++ EQ+ +E + +R R E ER R
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCRE-EEELQQEE-EQLLREE-----REKRRRQELERQYR 1141
Query: 452 AQRE-QIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKR 510
+ E Q E+E+L E+ R Q EL RQ RE ++E+Q EE + L+EE +KR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQ---ELERQYRE--EEELQQ-----EEEQLLREEQEKR 1191
Query: 511 RERIDEIKRKKLEELRATGLPEKYCIEAER 540
R+ + R++ EEL+ ++Y E +R
Sbjct: 1192 RQERERQYREE-EELQRQKRKQRYRDEDQR 1220
Score = 115 bits (287), Expect = 1e-25
Identities = 108/455 (23%), Positives = 233/455 (51%), Gaps = 47/455 (10%)
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQ 178
L RE+ R+Q ++E++ + + R++ +++++ + + + EE E+ +
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
R +L+ EQEE + L + R Q KQQ+++ D EE+R ++ +++E ++
Sbjct: 443 REQRLKREQEER-----RDWLKREEETERHEQERRKQQLKR--DQEEERRERWLKLEEEE 495
Query: 239 SIQRQEELERK-RREERIRGRRQIVEQMEKNQEERSLLAEQR-EQEKEQMLEYMEQLQEE 296
++QE E++ RRE+ R +++ Q E+ + ++ L +EQ+ +E+E+ E + + +EE
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 297 DLKDMERRQQQKLKMQAEIKR---INDENQKQKAELLAQEKLADQMVMEFTKKKMAREAE 353
+ ERR+Q +LK + E +R + E ++++ L +++ +++ ++++ R +
Sbjct: 556 KRLEQERREQ-RLKREQEERRDQLLKREEERRQQRLKREQE--ERLEQRLKREEVERLEQ 612
Query: 354 FEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE---NA 410
E ++R++RE+ +E R + ++ + Q+ + +Q R QE ++ +R+E+E
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR--EQQERREQRLKREEEEERLEQ 670
Query: 411 RKKMETEAELRKSRL---EQVAFKEHALA--------VQVQRDRDEFERILRAQREQIEK 459
R K E E E R+ L EQ +E + ++ + D + + R ++++ ++
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 460 ERLEEEKKATGRLQHANELRRQVRE----NQQKEVQNRIATF--------EEGR-RLKEE 506
R E+E+K R + +EL+ Q E QQ+E Q R T+ E GR RL
Sbjct: 731 RRQEQEEK---RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 507 AQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
R +R +++ ++ ++ LPE+ E R+
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Score = 112 bits (280), Expect = 9e-25
Identities = 136/528 (25%), Positives = 241/528 (45%), Gaps = 89/528 (16%)
Query: 75 KPETIQLITRDMVRELIVPTEDPSGE---SLIISPEEFERIKWASHVLTREELEARDQAF 131
K E ++ + ++ RE + E+P E L+ S E+ ER L RE+ E R+Q
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER---RQQQLRREQQERREQRL 659
Query: 132 KKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL 191
K+E+E +++ ++ E + + +E A+ER ++ + + + ++E E +
Sbjct: 660 KREEEEER----LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW-QWQLESEADA 714
Query: 192 KDMSKIILNAKCHAIRDAQILEKQQIQKELDT---EEKRLDQMMEVERQK---SIQRQEE 245
+ K R Q E+++ ++E + EE+R + + E Q+ + Q Q E
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774
Query: 246 LERKRREERIRGRRQIVEQMEKN-------QEERSLLAEQ----------REQEKE-QML 287
+ +R +R+ R + EQ E+ Q E+ L E+ RE+EKE Q L
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 288 EYMEQLQ----------EED--LKDMERRQQQKLKMQAEIK-RINDENQKQKAELLAQEK 334
E EQLQ EED +D ERR+ Q+ + + + ++ +E ++++ L A+
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 335 LADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRA--- 391
L +Q+ +K+ E E E +R REK + + R +E+ Q Q E+ LR
Sbjct: 895 LQEQL-----RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 392 KRNQEVADREWRRKEK----------ENARKKMETEAELRKSRLEQVAFKEHALAVQVQ- 440
KR ++ +R++R+ +K E K+ E E + E++ +E L + +
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 441 -RDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQ------- 491
R R E+ER R + E Q E+E+L E++ RLQ R+ E QQ+E Q
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 492 -------------NRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
EE + L+EE +KRR + E + ++ EEL+
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Score = 110 bits (276), Expect = 3e-24
Identities = 104/438 (23%), Positives = 217/438 (49%), Gaps = 53/438 (12%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA 180
RE E +Q+ K+E+ + ++ ++ E +W ++ + EE E Q LQ
Sbjct: 146 RELAEGEEQSEKQER-------LEQRDRQRRDEELWRQRQEWQEREERRAEEEQ--LQSC 196
Query: 181 NKLRMEQ---EEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQ 237
E+ EE+L+ + L K EKQQ ++E + ++ E ++
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGRE-------EKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 238 KSIQRQEELERKRREERIRGRRQIVEQMEKNQE-ERSLLAEQREQEKEQMLEYMEQLQEE 296
+++ R+EE K +EE + +R++ E+ E+ ++ ER L +R++E++Q + Q
Sbjct: 250 ETVLRKEE--EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 297 DLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVM-----EFTKKKMARE 351
++ ERR+QQ+ + + + +R E ++++ QE+ +Q + E ++++ RE
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 352 AEFEAEQERIRRE----KEKEIAR---LRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
E E ++++RRE +E+++ R LR Q+ ++ Q ++ + +R Q++ + R
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLR 426
Query: 405 KEKENARKKMETEAELRKSRL---------------EQVAFKEHALAVQVQRDRDEFERI 449
+E+E R + + E E R+ RL E ++ Q++RD++E R
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 450 LRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQK 509
+ E E+ER E++++ +L+ E RR+ R +Q+E + ++L+ E ++
Sbjct: 487 RWLKLE--EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 510 RRER-IDEIKRKKLEELR 526
RRE+ + + K+LE+ R
Sbjct: 545 RREQLLKREEEKRLEQER 562
Score = 110 bits (276), Expect = 3e-24
Identities = 108/479 (22%), Positives = 235/479 (49%), Gaps = 68/479 (14%)
Query: 108 EFERIKWAS---HVLTREELEARDQ--AFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKL 162
E ER +W H E+LE +Q A ++++++ + + R++ ++K ++K
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE-REEKRRRQETDRKF 1338
Query: 163 SDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELD 222
+ E++ +ER + L+R + R +EEEL+ + + + Q L +Q+ +++
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQ-----GRKFLEEEQRLRRQERERKFL 1393
Query: 223 TEEKRL---DQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQR 279
EE++L ++ ++ + + + +EE ++ R+ER R R+ +Q+ + + ER L E++
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 280 EQEKEQMLEYMEQ---LQEEDLKDMERRQQQK--LKMQAEIKRINDENQKQKAELLAQEK 334
+ +E+ ++ E+ LQE + + + R+++ + L+ + +++R + + ++ EL +QE
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Query: 335 LADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRN 394
+ E + R+ +F E++++RR++ + R ++ ++ Q Q+ + +
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 395 QEVADREWRRKEK-----ENARKKMETEAELRKSRLEQVA-------FKEHALAVQV--- 439
++ DR++R +E+ E RK ME E +LR+ +Q F+E +Q
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 440 ------QRDR---DEFERILRAQREQI-------------------EKERLEEEKKATGR 471
+RDR +E ++ R +REQ E+++L +++
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 472 LQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRE------RIDEIKRKKLEE 524
+ +LRRQ RE + + + ++ E R+ +EE Q R+E R E RK LEE
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752
Score = 105 bits (261), Expect = 1e-22
Identities = 94/417 (22%), Positives = 216/417 (51%), Gaps = 27/417 (6%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNN--NKKLSDLEEVAKERAQNLLQ 178
+EE + R + ++ E +K+ +++E+ ++K LE+ ++R L
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
R + E+EE + ++ C + +++Q+++ E +R + E ++Q+
Sbjct: 175 RQRQEWQEREERRAEEEQL---QSCKGHETEEFPDEEQLRRRELLELRRKGR--EEKQQQ 229
Query: 239 SIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDL 298
+RQ+ + ++ E+ R R ++ + E+ +E ++ QE+E+ L +E+ +
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 299 KDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQ 358
+ E +QQQ+L+ + +++R +E ++++ E +++ + E ++++ RE E E +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE-ERRE 348
Query: 359 ERIRREKEKEIA--RLRAMQEKAQDYQAEQDALRAKRNQEVA-DREWRRKEKENARKKME 415
+++RRE+E+E +LR QE+ + Q + + +R Q++ +++ RR+++ +++
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 416 TEAELRKSRLEQVAFKEHALAVQVQRDRDEFE-----RILRAQREQIEKERLEEEKKATG 470
E +LR+ EQ +E L + + +R E + R R +REQ E+ + ++ T
Sbjct: 409 REQQLRR---EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 471 RLQHANELRR-QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R H E R+ Q++ +Q++E + R EE EE ++++ER ++ R++ EE R
Sbjct: 466 R--HEQERRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLRREQEERR 515
Score = 104 bits (260), Expect = 2e-22
Identities = 117/547 (21%), Positives = 240/547 (43%), Gaps = 59/547 (10%)
Query: 8 ILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTL 67
+L R + +YR + + +E L + + + Q R K LQ+
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER--QYRKKDELQQ-- 1028
Query: 68 TALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEAR 127
E QL+ + + + E E + EE + + R+ELE +
Sbjct: 1029 ---------EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Query: 128 DQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQ 187
++KE+E + ++ +K ++ + EE+ +E Q L + K R ++
Sbjct: 1080 ---YRKEEELQQEEEQLLRE-EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 188 -------EEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRL----DQMMEVER 236
EEE++ + +L + R ++ + + ++EL EE++L + ER
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 237 QKSIQRQEELERKRREERIRG---RRQIVEQMEKNQE----ERSLLAEQREQEKEQMLEY 289
++ + +EEL+R++R++R R R + Q E +E + + + RE E+ + LE
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 290 MEQLQEEDLKDMER---------RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV 340
+ + +D++ R+Q++ + Q + +E Q ++ E + K D+
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-KEAKRRDRKS 1314
Query: 341 MEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR 400
E +K++ RE E E++R R+E +++ +E+ + EQ R +R+++ +
Sbjct: 1315 QE--EKQLLRE---EREEKRRRQETDRKFRE----EEQLLQEREEQPLRRQERDRKFREE 1365
Query: 401 EWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRD---RDEFERILRAQREQI 457
E R +E+ RK +E E LR+ E+ KE +R+ R + +R R + +Q+
Sbjct: 1366 ELRHQEQ--GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 458 EKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEI 517
++ + + + + E R+ E +Q+ Q R F E +L +E ++++ E
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 518 KRKKLEE 524
RK LEE
Sbjct: 1484 DRKFLEE 1490
Score = 103 bits (258), Expect = 3e-22
Identities = 89/357 (24%), Positives = 185/357 (51%), Gaps = 31/357 (8%)
Query: 207 RDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQME 266
RD Q+ E+ ++ +E+ + E+ + +R E+ +R+RR+E + +RQ ++ E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184
Query: 267 KNQEERSLLAEQREQEKEQMLEYMEQLQEEDL-----KDMERRQQQKLKMQAEIKRINDE 321
+ + E L + E E+ + EQL+ +L K E +QQQ+ + Q + + +E
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDE-EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 322 NQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQD 381
+ +K E + +++ ++ + E ++ R+ E + E+E++R+ + +E+ R R +E+ Q
Sbjct: 244 KEWRKRETVLRKE--EEKLQE---EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 382 YQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALA----- 436
+ LR K+ +E +++ R+E++ R++ E E ++ R EQ +E L
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERRE-QQLRREQEERREQQLRREQEE 357
Query: 437 ----VQVQRDRDEFERILRAQREQ-IEKE---RLEEEKKATGRLQHANELRR--QVRENQ 486
Q++R+++E R + +REQ + +E R E++ + +L+ +LRR Q+R Q
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 487 Q--KEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
Q +E Q R EE K E ++R +R+ + ++ + L+ E++ E ER+
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH--EQERR 472
Score = 103 bits (257), Expect = 4e-22
Identities = 93/365 (25%), Positives = 181/365 (49%), Gaps = 39/365 (10%)
Query: 198 ILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSI-----QRQEELERKRRE 252
+ A +A+ A L++++ + D +E L + E Q+ Q +EE ++RR+
Sbjct: 81 VAQACYYALGQATGLDEEK-RARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ 139
Query: 253 ERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQ 312
+R R++ E E+++++ L R++ E++ ++ QE + + E Q Q K
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH 199
Query: 313 AEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRRE-------- 364
E + DE Q ++ ELL + + + +++ R + E E+E +RE
Sbjct: 200 -ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 365 --KEKEIARLRAMQEKAQDY-QAEQDALRAKRNQEV-------ADREWRRKEKENARKKM 414
+E+E R R +QE+ + + E+ LR +R +E +++ RRK++E R++
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 415 ETEAELRKSRLEQVAFKEHAL--------AVQVQRDRDEFERILRAQREQIEKERLEEEK 466
E E ++ R +Q +E L Q++R+++E R + +REQ E+ER E++
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ-EEERREQQL 377
Query: 467 KATGRLQHANELRR--QVRENQQKEVQNRIATFEEGRR---LKEEAQKRRERIDEIKRKK 521
+ +L+ +LRR Q+R QQ + ++ ++ RR L+ E Q RRE+ +E +K
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 522 LEELR 526
E+ R
Sbjct: 438 HEQER 442
Score = 98.2 bits (243), Expect = 2e-20
Identities = 103/418 (24%), Positives = 206/418 (49%), Gaps = 44/418 (10%)
Query: 121 REELEARDQAFKKEKEATM---DAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLL 177
R+ LE Q +++++ + + R++ +Q+ + ++K + E++ +ER + L
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ--DRDRKFREEEQLRQEREEQQL 1572
Query: 178 QRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRL---DQMMEV 234
R + R + EE K + + + D Q L +Q+ Q++L E R D+ +
Sbjct: 1573 SRQERDRKFRLEEQKVRRQ---EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 235 ERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQR--EQEKEQMLEYMEQ 292
ER++ ++E +RK EE + RRQ EQ ++ +R E++ ++ +EQ L +
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL----R 1685
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
QE D K E QQ + + + E K + +E Q ++ EL + + +Q+ E ++++ R+
Sbjct: 1686 RQERDRKFREEEQQLR-RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 353 EFEA--EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRK--EKE 408
+ E+E++R E+E++ R QE+ + ++ E+ + + Q++ +E RK E+E
Sbjct: 1745 RYRKILEEEQLRPEREEQQLR---RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 409 NARKKMETEAELRKSRLEQVAFKEHALAV--QVQRDRDEFERILRAQRE---QIEKERLE 463
R++ E + + R + ++E L + Q QR R E +R RA+ + Q + R E
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 464 EEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKK 521
+E + E R++RE E RR ++E Q+ R+ + EIK ++
Sbjct: 1862 QELWQEEEQKRRQERERKLRE-------------EHIRRQQKEEQRHRQ-VGEIKSQE 1905
Score = 89.0 bits (219), Expect = 1e-17
Identities = 91/383 (23%), Positives = 182/383 (47%), Gaps = 47/383 (12%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMK---------QKEMVWN 157
EE R + L+R+E RD+ F+ E++ RK + Q+++
Sbjct: 1560 EEQLRQEREEQQLSRQE---RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLR--MEQEEELKDMSKIILNAKCHAIRDAQILEKQ 215
++K + E++ +ER + L R + R +E+E +L+ + + RD + E++
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER---EQQLRHDRDRKFREEE 1673
Query: 216 QIQKELDTEEKRLDQMMEVERQKSIQ-RQEELERKRREERIRGRRQIVEQMEKNQEERSL 274
Q+ +E + ++ R + R++ Q R++E ERK +E + RRQ +E+ K +EE L
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER--KFREEEQL 1731
Query: 275 LAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEK 334
E +++ + Y + L+EE L+ R++Q+L+ Q ++ +E Q L QE+
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRP--EREEQQLRRQERDRKFREEEQ------LRQER 1783
Query: 335 LADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRN 394
Q+ + + +K E + E+E + ++ + R +E+ Q + EQ R
Sbjct: 1784 EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ------RL 1837
Query: 395 QEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQR 454
++ DR++R +E+ ++K E EQ ++E + +R+R E +R Q+
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRRE--------EQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 455 EQIEKER-----LEEEKKATGRL 472
++ ++ R +E K GRL
Sbjct: 1890 KEEQRHRQVGEIKSQEGKGHGRL 1912
Score = 38.1 bits (87), Expect = 0.021
Identities = 35/106 (33%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 440 QRDRDEFERILRAQREQIEK-ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFE 498
++ R E ER L EQ EK ERLE+ R + EL RQ +E Q++E R A E
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRD----RQRRDEELWRQRQEWQERE--ERRAEEE 191
Query: 499 EGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANI 544
+ + K + ++++R++L ELR G EK ER+ +
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 125 bits (315), Expect = 8e-29
Identities = 111/468 (23%), Positives = 248/468 (52%), Gaps = 40/468 (8%)
Query: 63 LQKTLTALGLDRKPETI---QLITRDMVRELIVPTEDPSGESLIISPEEFER-IKWASHV 118
L K AL L+ TI +L ++ + +P + + ++ +E +R ++ A +
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFL 261
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQ 178
L + + + +++E + KKI KQ+E +W ++L + E +E+ + + +
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQ---EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWR 318
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+ +LR EQE+EL++ K + K +R+ + ++Q +K + EEK +Q ++ RQ+
Sbjct: 319 QEKRLR-EQEKELREQEKELREQK--ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 239 SIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDL 298
+R E E++ RE+ EQ ++QEER ++R +EKE+ + E++ E+
Sbjct: 376 --ERLWEQEKQMREQ---------EQKMRDQEERMWEQDERLREKEERMREQEKMWEQ-- 422
Query: 299 KDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQ 358
+E+ +++K KMQ + K+ D+ +K + E +E+ ++ + E + +E + + ++
Sbjct: 423 --VEKMREEK-KMQEQEKKTRDQEEKMQEEERIRER--EKKMREEEETMREQEEKMQKQE 477
Query: 359 ERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEA 418
E + ++EKE + R ++K + ++ E + QE ++ W ++EK +++M +
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQE-------KMQEQEEKIWEQEEKIRDQEEMWGQ- 529
Query: 419 ELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANEL 478
E + R E++ +E + Q ++ RD+ E+ + Q E++EK+ E+EKK + + E
Sbjct: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQ-EQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 479 RRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEI--KRKKLEE 524
R +RE ++K + E+ +++E+ +K +E+ +++ + +K++E
Sbjct: 589 ER-MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Score = 124 bits (312), Expect = 2e-28
Identities = 103/441 (23%), Positives = 228/441 (51%), Gaps = 44/441 (9%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTR------------KKIMKQKEMVWN 157
+R++ L +E E R+Q +E+E M + +K+ +Q+E +W
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQI 217
K++ + E+ +++ + + ++ +LR E+EE +++ K+ + +R+ + +++Q+
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLR-EKEERMREQEKMW--EQVEKMREEKKMQEQE- 436
Query: 218 QKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAE 277
+K D EEK ++ ER+K ++ +EE R++ E+ + + EQ EK +++ L E
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL-PE 495
Query: 278 QREQ--EKEQMLEYMEQL--QEEDLKDMERRQQQKLKMQAEIKRINDENQ---------K 324
Q+E+ E+E+M E E++ QEE ++D E Q+ KM + K E+Q
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555
Query: 325 QKAELLAQEKLADQMVMEFTKK------KMAREAEFEAEQERIRREKEKEIARLRAMQEK 378
Q+ ++ QE+ ++ E KK KM E ++++R E+E + MQE+
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 379 AQDYQAEQDAL--RAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALA 436
+ Q +++ + + ++ QE ++ W ++EK +++ E + + E++ EH
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL--WEHEKM 673
Query: 437 VQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIAT 496
+ ++ +++ E+I ++E++EK+ E+EKK + + E + RE + +E + +
Sbjct: 674 QEQEKMQEQEEKIW--EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 497 FEEGRRLKEEAQKRRERIDEI 517
EE +++E+ +K +E+ +E+
Sbjct: 732 QEE--KMQEQEEKMQEQEEEM 750
Score = 106 bits (265), Expect = 5e-23
Identities = 97/380 (25%), Positives = 191/380 (50%), Gaps = 26/380 (6%)
Query: 171 ERAQNLLQRA--NKLRME---QEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEE 225
ERA+ LL + N L+ E QEEEL++ K I + R + L +Q E
Sbjct: 256 ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ--------EG 307
Query: 226 KRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQ 285
K +Q ++ RQ+ R++E E + +E+ +R ++++ EQ E+ QE+ + EQ E+ +EQ
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 286 MLEYMEQLQEEDLKDME---RRQQQKLKMQAEIKRINDENQKQKAELLA-QEKLADQMVM 341
E QEE L + E R Q+QK++ Q E DE ++K E + QEK+ +Q+
Sbjct: 368 --EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 342 EFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADRE 401
+KKM + + +QE +E+E+ R + M+E+ + + +++ + Q+ +
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM-----QKQEENM 480
Query: 402 WRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKER 461
W ++EKE ++++ + E + E++ +E + Q ++ RD+ E + +++ +E+
Sbjct: 481 WEQEEKEWQQQRLPEQKE-KLWEQEKMQEQEEKIWEQEEKIRDQ-EEMWGQEKKMWRQEK 538
Query: 462 LEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKK 521
+ E++ + + Q +Q++ ++ + E+ +EE + ER+ E ++K
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 522 LEELRATGLPEKYCIEAERK 541
EE E+ E E K
Sbjct: 599 REEEEMMREQEEKMQEQEEK 618
Score = 103 bits (258), Expect = 3e-22
Identities = 98/433 (22%), Positives = 228/433 (52%), Gaps = 28/433 (6%)
Query: 132 KKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL 191
K+E+ + + + + M++++ + KK D EE +E + + +R K+R E+E
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-ERIREREKKMREEEETMR 467
Query: 192 KDMSKIILNAKCHAIRDAQILEKQQI--QKELDTEEKRLDQMMEV--ERQKSIQRQEEL- 246
+ K+ + ++ + ++Q++ QKE E++++ + E E+++ I+ QEE+
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 247 --ERKR-REERIRGRR-QIVEQMEK--NQEERSLLAEQREQEKEQMLEYMEQLQEEDLKD 300
E+K R+E++R + Q+ EQ EK +QE++ E+R ++K Q E QEE +++
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
Query: 301 MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQ--MVMEFTKKKMAREAEFEAEQ 358
ER ++++ KM+ E + + ++ +K + + +EK+ +Q + E +K +E + ++
Sbjct: 588 EERMREREKKMREEEEMMREQEEKMQEQ---EEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 359 ERIRREKEK--EIARLRAMQEKAQDYQAEQDALRAKR------NQEVADREWRRKEKENA 410
E++ ++EK E RL +EK +++ Q+ + + QE +++ + +EK+
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 411 RKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIE-KERLEEEKKAT 469
++ E E + R +++ +E + Q ++ +++ E++ + E E +E++ E+++
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Query: 470 GRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKL--EELRA 527
Q E + ++ E+++ + Q +I EE R +EE + +E + +K+ +E +
Sbjct: 765 WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM 824
Query: 528 TGLPEKYCIEAER 540
G EK + E+
Sbjct: 825 WGQEEKMWGQEEK 837
Score = 102 bits (255), Expect = 7e-22
Identities = 105/480 (21%), Positives = 216/480 (45%), Gaps = 79/480 (16%)
Query: 57 LRDKHTLQKTLTALGLDRKPETIQLITRDMVREL-----IVPTEDPSGESLIISPEEFER 111
+R++ + + + + ++K + + TRD ++ I E E E+ E+
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK 472
Query: 112 I-KWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEV-- 168
+ K ++ +EE E + Q ++KE + ++K+ +Q+E +W +K+ D EE+
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWE----QEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 169 --AKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEK 226
K Q ++ EQEE+++D + + + + + Q EK K D EEK
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK----KTWDQEEK 584
Query: 227 RLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE---QEK 283
++ ER+K ++ +EE+ R++ E+ ++ EQ EK E+ + EQ E +++
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 284 EQMLEYMEQL--------QEEDLKDMERRQQQKLKMQAEIK-----RINDENQKQKAELL 330
E+M E E++ Q+E L + E+ Q+Q+ + E K ++ + Q+Q+ +
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 331 AQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRA--MQEKAQDYQAEQDA 388
QEK+ ++ M +KKM E E EQE +E+E+++ +++ + ++ E+
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Query: 389 LRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFER 448
+R E ++ W ++ + K E E ++R E++ +E + Q ++ R + E+
Sbjct: 765 WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE-EKMRGQEEKMRGQEEKMRGQEEK 823
Query: 449 I--------------------------------------LRAQREQI----EKERLEEEK 466
+ +R Q E++ EK R +EEK
Sbjct: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/339 (23%), Positives = 174/339 (51%), Gaps = 32/339 (9%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
+E + DQ K +E M KK+ +++EM+ +K+ + EE +E+ + + ++
Sbjct: 574 QEKKTWDQEEKMREEERMRE--REKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQI--QKE-LDTEEKRLDQMMEVERQK 238
K++ EQEE++ + + + ++ ++ E+Q++ QKE L EK +Q E+++
Sbjct: 632 KMQ-EQEEKMWEQEEKMWE------QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEE 684
Query: 239 SIQRQEELERKRRE--------ERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYM 290
I QE++E+K +E E++R + E+ +K +EE ++ EQ E+ +EQ E
Sbjct: 685 KIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ--EEK 742
Query: 291 EQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAR 350
Q QEE++ + E + ++ + E +R+ + QK +L EK+ +Q +K +
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPE----QKEKLWEHEKMQEQ------EKIWEQ 792
Query: 351 EAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENA 410
E + ++E++R ++EK + M+ + + +++ + + + E ++E
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM 852
Query: 411 RKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERI 449
+KM+ + E + + E++ +E + Q ++ R + E+I
Sbjct: 853 EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 84.7 bits (208), Expect = 2e-16
Identities = 77/350 (22%), Positives = 181/350 (51%), Gaps = 32/350 (9%)
Query: 213 EKQQIQKELDTEEKRLDQMME----------VERQKSIQRQEELERKRREERIRGRRQIV 262
E Q+ + T K+ D+ +E +E ++ EEL++K E + + +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ---EKLPL 236
Query: 263 EQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDEN 322
+ EK++ + ++ +R+ E+ + L + Q+Q L++ RQ+++L+ Q + R +E
Sbjct: 237 AESEKSEIQLNVKELKRKLERAKFL--LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEK 294
Query: 323 QKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDY 382
++ E L ++ + M ++KM R+ + EQE+ RE+EKE+ + ++E+ +
Sbjct: 295 MWRQEERLREQ----EGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQM 350
Query: 383 QAEQDAL--RAKRNQEVADREWRRKEK--ENARKKMETEAELRKSRLEQVAFKEHALAVQ 438
Q +++ + + ++ +E ++ WR++E+ E ++ E E ++R E++ ++ L +
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE-ERMWEQDERLREK 409
Query: 439 VQRDRDEFERILRAQREQIEKERLEEEKKATG---RLQHANELR---RQVRENQQ--KEV 490
+R R++ + + ++ + EK+ E+EKK ++Q +R +++RE ++ +E
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469
Query: 491 QNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAER 540
+ ++ EE +EE + +++R+ E K K E+ + EK + E+
Sbjct: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
Score = 55.1 bits (131), Expect = 2e-07
Identities = 66/270 (24%), Positives = 122/270 (45%), Gaps = 42/270 (15%)
Query: 279 REQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEK-LAD 337
+E++ + Y + E+LK Q+KL + K N K+ L + K L
Sbjct: 204 KERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
Query: 338 QMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEV 397
Q+ +++M R+ E EQE+ R++E+++ R +E+ ++ + + R QE
Sbjct: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR---QEERLREQEGKM------REQE- 313
Query: 398 ADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQI 457
++ WR++ ++ E E ELR+ E R++ E +EQ
Sbjct: 314 -EKMWRQE-----KRLREQEKELREQEKEL-------------REQKELREQEEQMQEQE 354
Query: 458 EKERLEEEK------KATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRR 511
EK +EEK K + + E +Q+RE +QK +E+ RL+E+ ++ R
Sbjct: 355 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414
Query: 512 ERIDEIKRKKLEELRATGLPEKYCIEAERK 541
E+ E +++E++R EK E E+K
Sbjct: 415 EQ--EKMWEQVEKMR----EEKKMQEQEKK 438
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/220 (22%), Positives = 94/220 (42%), Gaps = 47/220 (21%)
Query: 105 SPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSD 164
S E E+ + RE+ E + +K +E + +K+ +Q+E +W +
Sbjct: 714 SMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR---- 769
Query: 165 LEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTE 224
EQ+E+L + K+ Q+ +K + E
Sbjct: 770 -------------------LPEQKEKLWEHEKM-----------------QEQEKIWEQE 793
Query: 225 EKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKE 284
EK DQ ++ Q+ R +E + + +EE++ G+ E+ QEE+ E++ +E
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ----EEKMWGQEEKMWGQEEKMWGQE 849
Query: 285 QMLEYMEQLQEEDLKDME---RRQQQKLKMQAEIKRINDE 321
+ +E Q QEE +++ E R Q++K++ Q E R +E
Sbjct: 850 EKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 123 bits (308), Expect = 5e-28
Identities = 99/458 (21%), Positives = 240/458 (52%), Gaps = 44/458 (9%)
Query: 87 VRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKE---ATMDAVM 143
++E + E E + E +++ A +L +++L+A KE + A + A +
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285
Query: 144 TRKKI-----MKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKII 198
++ +Q+E +W +K+ + EE +E+ + + ++ K+R EQEE+++ +++
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-EQEEKMRRQEEMM 344
Query: 199 LNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR 258
++ ++ ++++ E + + +RL++MM + +K ELE K E+
Sbjct: 345 WE------KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI----RELEEKMHEQE---- 390
Query: 259 RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQL---QEEDLKDMER---RQQQKLKMQ 312
+I EQ EK QEE + +++ QE+E + E+ QEE +++ E+ RQ++K+ Q
Sbjct: 391 -KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 313 AEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEK---EI 369
+I+ ++ Q+Q+ +EK+ +Q + K+KM + + ++E++ R++EK +
Sbjct: 450 EKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508
Query: 370 ARLRAMQEK---AQDYQAEQDALRAKRNQEVADREWRRKEKE----NARKKMETEAELRK 422
++R +EK ++ EQ+ ++ +++ ++E +E+E +KM+ + ++R+
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 423 SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL--EEEKKATGRLQHANELRR 480
E++ +E + Q ++ R++ E+I + + E+E + E+E+K + + E
Sbjct: 569 QE-EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 481 QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIK 518
+++E ++K + +E+ RL+++ +K +E + ++
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 113 bits (282), Expect = 5e-25
Identities = 115/485 (23%), Positives = 240/485 (49%), Gaps = 62/485 (12%)
Query: 114 WASHVLTREELEARDQA--------FKKEKEATMDAVMTRKK--------IMKQKEMVWN 157
++ H + + E EARD F E E + AV T+KK + K+++ +
Sbjct: 148 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL 207
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSKIILNAKCHAIRDAQILEK 214
+ + +E KE+ L ++ + E+ E +K++ + + AK + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 215 QQIQKELDTEEKRLD-QMMEVERQKSIQRQEELERKRREERIRG-RRQIVEQMEKNQEER 272
+ KEL + +L Q+ E E + +Q+E + R+EE+I+ +I EQ EK +E+
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 273 SLLAEQREQ---------EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQ 323
+ EQ E+ EKE+ + E++ E + M R ++ + + +I+ + ++
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH 387
Query: 324 KQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAM-------- 375
+Q+ +EK ++ + +K+ +EA+ ++E+IR ++EK + + M
Sbjct: 388 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 447
Query: 376 -QEKAQDYQAEQDALRAKRNQE-VADRE--WRRKEK----ENARKKME---TEAELRKSR 424
QEK ++ + Q+ R +E + ++E WR+KEK E RK+ E + E +
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 425 LEQVAFKEHALAVQVQRDRDEFERILRAQREQI--EKERLEEEKKATG----RLQHANEL 478
E++ +E + Q ++ R++ E+I R Q E+I ++E ++E+++ G ++Q ++
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKI-REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Query: 479 RRQ---VRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYC 535
RRQ +RE ++K + + E+ ++ E+ +K RE+ +E+ +++ E++ EK C
Sbjct: 567 RRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ-EEMMQEQEEKMWEQ--EEKMC 623
Query: 536 IEAER 540
+ E+
Sbjct: 624 EQEEK 628
Score = 109 bits (273), Expect = 6e-24
Identities = 95/364 (26%), Positives = 190/364 (52%), Gaps = 32/364 (8%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRK--KIMKQKEMVWNNNKKLSDLEE 167
E+I+ + +E + R+Q +EK + +M K K+ +Q+EM+W +K+ LEE
Sbjct: 314 EKIQEQEEKIREQEEKIREQ---EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 168 VAKERAQNLLQRANKLR-----MEQEEELKDMSKIILNAKCHAIRDAQILE-----KQQI 217
+ E+ + + + K+ EQEE+ ++ KI K ++A++ ++Q
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE-QEAKMWRQEEKIREQE 429
Query: 218 QKELDTEEKRLDQMMEVERQKSIQ----RQEELERKRREERIRGRRQIVEQMEKNQEERS 273
+K + E+K Q ++ Q+ I+ RQE+ E R+EE+IR + +I Q EK E+
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 274 LLAEQRE--QEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLA 331
+ ++ + +++E+M + E+++E++ K RQ++K++ Q E R +E +++ E++
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMW--RQEEKIREQEEKIREQEEKIREQEEMMQ 547
Query: 332 Q--EKLADQMVMEFTKKKMAREAEFEAEQE-RIRREKEKEIARLRAMQEKAQDYQAEQDA 388
+ EK+ +Q ++KM R+ E EQE +IR +KEK +R +EK + Q E+
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK----IREQEEKIWE-QEEKIR 602
Query: 389 LRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFER 448
+ + QE ++ W ++EK +++ E E + R E+ +++ Q + E +
Sbjct: 603 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Query: 449 ILRA 452
L A
Sbjct: 663 HLEA 666
Score = 89.7 bits (221), Expect = 6e-18
Identities = 57/230 (24%), Positives = 131/230 (56%), Gaps = 17/230 (7%)
Query: 108 EFERIKWASHVLTREELEARDQAFKKEKEA--TMDAVMTRKKIMKQKEMVWNNNKKLSDL 165
E E+I+ +EE+ +++ ++++E + + ++KI KQ+E VW +K+ D
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 166 EEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEE 225
EE +E+ + + ++ K+R EQEE++++ + IR+ + + ++Q +K + EE
Sbjct: 508 EEKIREQEEKMWRQEEKIR-EQEEKIREQEE--------KIREQEEMMQEQEEKMGEQEE 558
Query: 226 KRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE---QE 282
K +Q +++ I+ QEE R+++E+ +I EQ EK +E+ ++ EQ E ++
Sbjct: 559 KMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQ 618
Query: 283 KEQMLEYMEQLQEEDLK---DMERRQQQKLKMQAEIKRINDENQKQKAEL 329
+E+M E E++QE++ K E+ +Q+++++ + +++ + + +A +
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 62.0 bits (149), Expect = 1e-09
Identities = 76/348 (21%), Positives = 153/348 (43%), Gaps = 39/348 (11%)
Query: 199 LNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR 258
L A+ H IR +K ++Q L + + Q+ E E + I R + K E +
Sbjct: 125 LEAQVHTIR-ILTCQKTELQMALYYSQHAVKQL-EGEARDLISRLHD-SWKFAGELEQAL 181
Query: 259 RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRI 318
+ Q +K L ++R+ ++ Y + +E+LK+ + Q+KL++ K
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLEL--YRNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 319 NDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEK 378
N K+ L + KL + + + +AE + + +E + A+L+A
Sbjct: 240 IQLNVKELKRKLERAKL------------LLPQQQLQAEADHLGKELQSVSAKLQA---- 283
Query: 379 AQDYQAEQDALRAKRNQEVADREWRRKEK-ENARKKMETEAELRKSRLEQVAFKEHALAV 437
Q E++ L + NQ+ ++ WR++EK + +K++ + E + + E++ +E +
Sbjct: 284 ----QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 438 QVQRDRDEFERILRAQREQIEKE----RLEEEKKATGRLQHANELRRQVRENQQKEVQNR 493
Q + ++ E++ R + EKE RLEE E ++RE ++K +
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW---------EKEEKIRELEEKMHEQE 390
Query: 494 IATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
+E +R +EE + +E+ E + K + E+ E E+K
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 438
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 120 bits (300), Expect = 4e-27
Identities = 111/427 (25%), Positives = 218/427 (51%), Gaps = 55/427 (12%)
Query: 107 EEFERIKWASHVLTREELEARDQAF----KKEKEATMDAVMTRK--KIMKQKEMVWNNNK 160
E+ E+++ ++ +E + R Q K+EK + +M K K+ +Q+EM+W +
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 391
Query: 161 KLSDLEEVAKERA-----QNLLQRANKLR-------------------MEQEEELKDMSK 196
K+ +LEE E+ + Q K+R EQEE++++ K
Sbjct: 392 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 451
Query: 197 IILNA--KCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKS-IQRQEELERKRREE 253
+ K H + EK+Q Q+E+ +E+++ + E+ RQK + QEE RK+ E+
Sbjct: 452 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Query: 254 RIRGRRQIVEQMEK--NQEERSLLAEQREQEKEQMLEYMEQLQEED-LKDMERRQQQKLK 310
R +I EQ EK QEE+ E++ +E+E+M E++ E++ + + E+RQ+Q+ K
Sbjct: 512 VWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571
Query: 311 MQAEIKRINDENQK---QKAELLAQEKLADQMVMEFTKK--KMAREAEFEAEQERIRREK 365
M + ++I ++ +K Q+ ++ QE+ + + K+ K+ + E EQE RE+
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADRE---WRRKEK--ENARKKMETEAEL 420
E++I M ++ ++ EQ+ ++ +++ ++E WR++EK E +K E E ++
Sbjct: 632 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 421 RKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRR 480
R+ E + +E + Q ++ ++ E++ +EQ EK R +EEK ++ LR+
Sbjct: 692 REQE-EMMQEQEEKMWEQEEKMCEQEEKM----QEQEEKMRRQEEKMWEQEVR----LRQ 742
Query: 481 QVRENQQ 487
Q + Q+
Sbjct: 743 QEEKMQE 749
Score = 115 bits (287), Expect = 1e-25
Identities = 124/514 (24%), Positives = 254/514 (49%), Gaps = 81/514 (15%)
Query: 87 VRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKE---ATMDAVM 143
++E + E E + E +++ A +L +++L+A KE + A + A +
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285
Query: 144 TRKKI-----MKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKII 198
++ +Q+E +W +K+ + EE +E+ + + ++ K+R EQEE+++ +++
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-EQEEKMRRQEEMM 344
Query: 199 LNAKCHAIRDAQIL----EKQQIQKEL--DTEEK--RLDQMM------------EVERQK 238
+ R +++ EK + Q+E+ + EEK R ++MM ++ Q+
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 239 SIQRQEEL----ERK--------------RREERIRGRRQIVEQMEK---NQEERSLLAE 277
I+ QEE E+ R+EE+IR + + + + EK QEE+ E
Sbjct: 405 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 278 Q-REQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQK---QKAELLAQ- 332
+ RE+EK Q E M + QEE + + E +QK KM + ++I + +K Q+ ++ Q
Sbjct: 465 KIREEEKRQEQEEMWR-QEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE 523
Query: 333 EKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAK 392
EK+ +Q ++KM R+ E EQE + RE+EK + + +E+ + Q ++ + +
Sbjct: 524 EKIREQ------EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577
Query: 393 RNQEVADREWRRKEK--ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERIL 450
+ +E ++ WR++EK E K+ E E ++ K E++ +E + Q ++ R++ E+I
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQE-EKIREQEEKIQEQEEKIREQEEKI- 635
Query: 451 RAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKR 510
REQ E + +EEK E ++ E ++K + + + +++E+ +K
Sbjct: 636 ---REQEEMTQEQEEK--------MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 511 RERIDEIKRK----KLEELRATGLPEKYCIEAER 540
RE+ ++I+ + + +E + EK C + E+
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Score = 113 bits (282), Expect = 5e-25
Identities = 109/456 (23%), Positives = 236/456 (51%), Gaps = 65/456 (14%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRK--KIMKQKEMVWNNNKKLSDLEE 167
E+I+ + +E + R+Q +EK + +M K K+ +Q+EM+W +K+ EE
Sbjct: 314 EKIQEQEEKIREQEEKIREQ---EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370
Query: 168 VAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKR 227
+ E+ + + +R ++ E+EE+++++ + + + IR+ + EK+Q ++++ +EKR
Sbjct: 371 MMWEKEEKM-RRQEEMMWEKEEKIRELEEKMHEQE--KIREQE--EKRQEEEKIREQEKR 425
Query: 228 LDQMMEV---------------ERQKSIQRQEEL-----------ERKRREERIRGRRQI 261
+Q ++ E++K + RQEE +R+ +EE R +I
Sbjct: 426 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485
Query: 262 VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDME---RRQQQKLKMQAEIKRI 318
EQ E+ ++ + EQ E+ ++Q E QEE +++ E R Q++K+ Q E R
Sbjct: 486 HEQ-EEIWRQKEKMHEQEEKIRKQ--EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Query: 319 NDENQKQKAELLAQEKLADQMVMEFTKKKMAREAE-FEAEQERIRREKEKEIARLRAMQE 377
+E +++ ++ QEK+ ++ + + KM R+ E ++E++ R++EK +R +E
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEK----IREQEE 598
Query: 378 KAQDYQAEQDALRAKRNQEVADREWRRKEKE----NARKKMETEAELRKSRLEQVAFKEH 433
K Q EQ+ K+ +++ ++E + +E+E +K+ + E+ + + E++ +E
Sbjct: 599 KRQ----EQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Query: 434 ALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQK--EVQ 491
+ Q ++ +++ E + R Q E+I E+EKK + + E ++E ++K E +
Sbjct: 655 KMCEQEEKMQEQEETMWR-QEEKIR----EQEKKIREQEEKIREQEEMMQEQEEKMWEQE 709
Query: 492 NRIATFEEGRRLKEEAQKRRER---IDEIKRKKLEE 524
++ EE + +EE +R+E E++ ++ EE
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 107 bits (266), Expect = 4e-23
Identities = 100/475 (21%), Positives = 227/475 (47%), Gaps = 49/475 (10%)
Query: 114 WASHVLTREELEARDQA--------FKKEKEATMDAVMTRKK--------IMKQKEMVWN 157
++ H + + E EARD F E E + AV T+KK + K+++ +
Sbjct: 148 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL 207
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSKIILNAKCHAIRDAQILEK 214
+ + +E KE+ L ++ + E+ E +K++ + + AK + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 215 QQIQKELDTEEKRLDQMMEVERQKSIQRQEELERK-RREERIR-GRRQIVEQMEKNQEER 272
+ KEL + +L +E + Q++ E+ R+EE+I+ +I EQ EK +E+
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 273 SLLAEQREQ-----------------------EKEQMLEYMEQLQEEDLKDMERRQQQKL 309
+ EQ E+ EKE+ + E++ E + M R+++
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 310 KMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEI 369
+ + +I+ + ++ +Q+ +EK ++ + +K+ +EA+ ++E+IR ++EK
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 370 ARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
+ + M + + EQ+ +R + ++ + WR++EK + ++++ + E + E++
Sbjct: 448 EQEKKMWRQEEKIH-EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQI--EKERLEEEKKATGRLQHANELRRQVRENQQ 487
+E + Q ++ R++ E+I R Q E++ ++E++ E+++ + +E + E ++
Sbjct: 507 KQEEKVWRQEEKIREQEEKI-REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR 565
Query: 488 KEVQNRIATFEEG-RRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
+E ++++ EE R +E+ ++ E+I E + K+ E+ E+ E E K
Sbjct: 566 QEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Score = 106 bits (265), Expect = 5e-23
Identities = 81/333 (24%), Positives = 183/333 (54%), Gaps = 29/333 (8%)
Query: 107 EEFERIKWASHVLTREE--LEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSD 164
E+ E+I+ + R+E + +++ ++EK + + +++ + ++E +W +K+ +
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 165 LEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQIL----EKQQIQKE 220
EE +++ + + ++ K+R EQEE++++ + + + IR+ + + EK Q++
Sbjct: 501 QEEKIRKQEEKVWRQEEKIR-EQEEKIREQEEKMWRQE-EKIREQEEMWREEEKMHEQEK 558
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE 280
+ EEKR +Q ++ RQ+ R++E + R+EE+IR EQ EK QE+ + +Q E
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR------EQEEKRQEQEEKMWKQEE 612
Query: 281 QEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV 340
+ +EQ E++QE++ K R Q++K++ Q E+ + +E ++ E + ++ +
Sbjct: 613 KIREQ----EEKIQEQEEK--IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ----EEK 662
Query: 341 MEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR 400
M+ ++ M R+ E EQE+ RE+E++I M ++ ++ EQ+ ++ +++ ++
Sbjct: 663 MQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722
Query: 401 EWRRKEKENARKKMETEAELRKSRLEQVAFKEH 433
E + + +E K E E LR+ ++ +EH
Sbjct: 723 EEKMRRQE--EKMWEQEVRLRQ---QEEKMQEH 750
Score = 58.9 bits (141), Expect = 1e-08
Identities = 75/353 (21%), Positives = 164/353 (46%), Gaps = 30/353 (8%)
Query: 199 LNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR 258
L A+ H IR +K ++Q L + + Q+ E E + I R + K E +
Sbjct: 125 LEAQVHTIR-ILTCQKTELQMALYYSQHAVKQL-EGEARDLISRLHD-SWKFAGELEQAL 181
Query: 259 RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKM-QAEIKR 317
+ Q +K L ++R+ ++ Y + +E+LK+ + Q+KL++ ++E
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLEL--YRNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 318 INDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQ- 376
I ++ K +L + L Q ++ + +E + + + + + E+ + RL Q
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 377 -------EKAQDYQ---AEQDALRAKRNQEVADRE----------WRRKEKENARKKMET 416
EK Q+++ EQ+ ++ +++ ++E W ++EK +++M
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359
Query: 417 EAELRKSRLEQVAF-KEHALAVQVQRDRDEFERILRAQREQIEKERL-EEEKKATGRLQH 474
E E + R E++ + KE + Q + ++ E+I + + E+E++ E+E+K +
Sbjct: 360 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 419
Query: 475 ANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQ-KRRERIDEIKRKKLEELR 526
+ +RQ +E + + +I EE R +E+ ++ E+I E ++ + EE R
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 117 bits (293), Expect = 3e-26
Identities = 104/457 (22%), Positives = 232/457 (50%), Gaps = 51/457 (11%)
Query: 87 VRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKE---ATMDAVM 143
++E + E E + E +++ A +L +++L+A KE + A + A +
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 346
Query: 144 TRKKI-----MKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKII 198
++ +Q+E +W +K+ + EE +E+ + + ++ K+R EQEE+++ +++
Sbjct: 347 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-EQEEKMRRQEEMM 405
Query: 199 LNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR 258
+ EK + Q+E+ E++ ++ RQ+ + ++E + + EE++ +
Sbjct: 406 WEKE----------EKMRRQEEMMWEKEE-----KMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 259 RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRI 318
+I EQ EK QEE + REQEK Q E QEE + R Q++K++ Q E
Sbjct: 451 EKIREQEEKRQEEEKI----REQEKRQEQEAKMWRQEEKI----REQEEKIREQEEKMWR 502
Query: 319 NDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKE---KEIARLRAM 375
+E ++ ++ +EK +Q M ++K+ + E ++E+I ++E K+ ++
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 376 QEKAQDYQ---AEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKE 432
+EK D + EQ+ ++ +++ ++E + +E+E +K+ + E+ + + E++ +E
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE---EKIREQEEMTQEQEEKMGEQE 619
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQK--EV 490
+ Q ++ +++ E+ +R Q E+I E+EKK + + E ++E ++K E
Sbjct: 620 EKMCEQEEKMQEQEEK-MRRQEEKIR----EQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 491 QNRIATFEEGRRLKEEAQKRRER---IDEIKRKKLEE 524
+ ++ EE + +EE +R+E E++ ++ EE
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Score = 107 bits (267), Expect = 3e-23
Identities = 85/359 (23%), Positives = 189/359 (52%), Gaps = 28/359 (7%)
Query: 107 EEFERIKWASHVLTREELEARDQAF----KKEKEATMDAVMTRK--KIMKQKEMVWNNNK 160
E+ E+I+ + +E + R Q K+EK + +M K K+ +Q+EM+W +
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438
Query: 161 KLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKE 220
K+ +LEE E+ + R + + ++EE++++ K + R + + +Q+ +K
Sbjct: 439 KIRELEEKMHEQEKI---REQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQE-EKI 493
Query: 221 LDTEEKRLDQMMEVERQKSIQ----RQEELERKRREERIRGRRQIVEQMEKNQEERSLLA 276
+ EEK Q ++ Q+ I+ RQE+ E R+EE+IR + +I Q EK E+ +
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIR 553
Query: 277 EQREQ---EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE 333
+Q E+ ++E+M + E+++E++ K RQ++K++ Q E R +E +++ E+ ++
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIREQEEKVW--RQEEKIREQEEKIREQEEKIREQEEMTQEQ 611
Query: 334 KLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKR 393
++ + E +K +E + + ++E++RR++EK + + ++E+ + + +++ +
Sbjct: 612 ---EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM---- 664
Query: 394 NQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRA 452
QE ++ W ++EK +++ E E + R E+ +++ Q + E + L A
Sbjct: 665 -QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 103 bits (258), Expect = 3e-22
Identities = 90/327 (27%), Positives = 173/327 (52%), Gaps = 43/327 (13%)
Query: 74 RKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKK 133
R+ E + + +REL E+ E I +E +R +EE + R+Q ++
Sbjct: 427 RRQEEMMWEKEEKIREL----EEKMHEQEKIREQEEKR---------QEEEKIREQEKRQ 473
Query: 134 EKEATMDAVMTR-----KKIMKQKEMVWNNNKKLSDLEEVAKERA----QNLLQRANKLR 184
E+EA M + +KI +Q+E +W +K+ + E++ +E + + ++ K+R
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 533
Query: 185 MEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQE 244
EQEE + KI + + IR + +Q +K D EEK +Q +V RQ+ R++
Sbjct: 534 -EQEEIWRQKEKI--HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590
Query: 245 ELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERR 304
E + + +EE+IR EQ E QE+ + EQ +E+M E E++QE++ K RR
Sbjct: 591 EEKIREQEEKIR------EQEEMTQEQEEKMGEQ----EEKMCEQEEKMQEQEEK--MRR 638
Query: 305 QQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRRE 364
Q++K++ Q + R +E +++ E++ ++ ++ + E +K +E + + ++E++RR+
Sbjct: 639 QEEKIREQEKKIREQEEKIREQEEMMQEQ---EEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695
Query: 365 KEK---EIARLRAMQEKAQDYQAEQDA 388
+EK + RLR +EK Q++Q +A
Sbjct: 696 EEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 102 bits (254), Expect = 9e-22
Identities = 117/471 (24%), Positives = 228/471 (48%), Gaps = 87/471 (18%)
Query: 114 WASHVLTREELEARDQA--------FKKEKEATMDAVMTRKK--------IMKQKEMVWN 157
++ H + + E EARD F E E + AV T+KK + K+++ +
Sbjct: 209 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL 268
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSKIILNAKCHAIRDAQILEK 214
+ + +E KE+ L ++ + E+ E +K++ + + AK + E
Sbjct: 269 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 328
Query: 215 QQIQKELDTEEKRLD-QMMEVERQKSIQRQEELERKRREERIRG-RRQIVEQMEKNQEER 272
+ KEL + +L Q+ E E + +Q+E + R+EE+I+ +I EQ EK +E+
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 388
Query: 273 SLLAEQREQ-----------------------EKEQMLEYMEQL---QEEDLKDMERR-- 304
+ EQ E+ EKE+ + E++ +EE ++++E +
Sbjct: 389 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 448
Query: 305 QQQKLKMQAEIK------RINDENQKQKAELLAQ-EKLADQ-MVMEFTKKKMAREAEFEA 356
+Q+K++ Q E + R ++ Q+Q+A++ Q EK+ +Q + ++KM R+ E
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH 508
Query: 357 EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMET 416
EQE+IR E+++ QE+ + ++ E+ + + +E+ WR+KEK + E
Sbjct: 509 EQEKIREEEKR--------QEQEEMWRQEE---KIREQEEI----WRQKEKIH-----EQ 548
Query: 417 EAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQ---REQIEKERLEEEKKATGRLQ 473
E ++RK E++ +E + Q ++ R++ E++ R + REQ EK R +EEK ++
Sbjct: 549 EEKIRKQE-EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK-----IR 602
Query: 474 HANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
E+ Q +E + E + ++ EE + +EE +R+E + KK+ E
Sbjct: 603 EQEEM-TQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 112 bits (279), Expect = 1e-24
Identities = 98/403 (24%), Positives = 200/403 (49%), Gaps = 26/403 (6%)
Query: 140 DAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSK 196
+A+ ++ + KE+ +KL+ E+AK + ++L + K+R + E EL+++ K
Sbjct: 71 EAIQKAEENKRLKELQLKQEEKLA--MELAKLKHESL--KDEKMRQQVRENSIELRELEK 126
Query: 197 IILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIR 256
+ A + R AQI EK I+ E + + + M E ++ I+ + E KR + + +
Sbjct: 127 KLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ 186
Query: 257 GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIK 316
+ +Q+E+ ++++ EQ +EK + E + ++ EED + +QQKL+ ++
Sbjct: 187 YYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED----QLEKQQKLEKMNAMR 242
Query: 317 RINDENQKQKAELLAQEKLADQM------VMEFTKKKMAREAEFEAEQERIRREKEKEIA 370
R +E QK++A L ++K ++M ++EF + RE E +++ +EK +
Sbjct: 243 RYIEEFQKEQA--LWRKKKREEMEEENRKIIEFANMQQQRE---EDRMAKVQENEEKRLQ 297
Query: 371 RLRAMQEKAQDYQAEQDALRAKRN---QEVADREWRRKEKENARKKMETEAELRKSRLEQ 427
A+ +K ++ +++ L R QE ++ K KE A KK+ + E+++ EQ
Sbjct: 298 LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQ 357
Query: 428 VAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQ 487
+A KE L + + + + +L E E + +K+ +L+H + + + E +Q
Sbjct: 358 MALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQ 417
Query: 488 KEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGL 530
+ + ++ EE +L++ Q I E +R KL + AT L
Sbjct: 418 QFLADKQRELEEW-QLQQRRQGFINAIIEEERLKLLKEHATNL 459
Score = 82.0 bits (201), Expect = 1e-15
Identities = 96/416 (23%), Positives = 190/416 (45%), Gaps = 57/416 (13%)
Query: 171 ERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQI------QKELDTE 224
ER Q L+ N + + LK+++ I N D ++ KQ + Q ELD E
Sbjct: 12 ERHQKLVDE-NYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDME 70
Query: 225 EKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKE 284
E + + E +R K +Q ++ E K E + + + ++ + Q+ R E RE EK+
Sbjct: 71 EA-IQKAEENKRLKELQLKQ--EEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKK 127
Query: 285 QMLEYMEQLQEEDLKDMERRQQQKLKMQAEI--------KRI-------NDENQKQKA-- 327
YM + + + + + + +++K AEI KRI D+ K KA
Sbjct: 128 LKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQY 187
Query: 328 ------ELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQD 381
+L QEK + + K+K+ + E + EK++++ ++ AM+ ++
Sbjct: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEE 247
Query: 382 YQAEQDALRAKRNQEV----------ADREWRRKE------KENARKKMETEAELRKSRL 425
+Q EQ R K+ +E+ A+ + +R+E +EN K+++ + L +
Sbjct: 248 FQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLE 307
Query: 426 EQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN 485
E + +E V+ + ++E I +++ ++ +++L ++K+ + L+ V +
Sbjct: 308 EMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQA 367
Query: 486 QQKEVQN----RIATFEEGRRLK-EEAQKRRERIDEIKR---KKLEELRATGLPEK 533
++E +N +A F E R++ AQK+R + E +R K +EE R L +K
Sbjct: 368 AKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADK 423
Score = 79.3 bits (194), Expect = 8e-15
Identities = 82/341 (24%), Positives = 168/341 (49%), Gaps = 23/341 (6%)
Query: 208 DAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK 267
D +K +Q + + +QM++ E +QR++ L + E+ + +++ E+
Sbjct: 19 DENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEE 78
Query: 268 NQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKA 327
N+ + L Q +QE++ +E + +L+ E LKD + RQQ + + E++ + +K KA
Sbjct: 79 NKRLKEL---QLKQEEKLAME-LAKLKHESLKDEKMRQQVR-ENSIELRELE---KKLKA 130
Query: 328 ELLAQEKLADQMVMEFTK-KKMAREAEFEAE--QERIRREKEKEIARLRAMQEKAQDYQA 384
+ +E+ A + K ++M R+AE +E R KE+ A + + KAQ Y
Sbjct: 131 AYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD 190
Query: 385 EQDALRAKRNQEVADREWRRKEK----ENARKKMETEAELRKSRLEQVAFKEHALAVQVQ 440
+ L + ++ E KEK E RK E + ++ +LE K +A+ ++
Sbjct: 191 LEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLE----KMNAMRRYIE 246
Query: 441 RDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEG 500
+ E + +RE++E+E + + A + Q + +V+EN++K +Q + A ++
Sbjct: 247 EFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQK- 305
Query: 501 RRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
EE ++RE +++++++ +E +A K EAE+K
Sbjct: 306 ---LEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKK 343
Score = 52.8 bits (125), Expect = 8e-07
Identities = 63/259 (24%), Positives = 128/259 (49%), Gaps = 36/259 (13%)
Query: 128 DQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQ 187
DQ K++K M+A+ + ++++ +W K+ E +E + +++ AN M+Q
Sbjct: 227 DQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKR-----EEMEEENRKIIEFAN---MQQ 278
Query: 188 EEELKDMSKIILN-AKCHAIRDA--QILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQE 244
+ E M+K+ N K +++A Q LE+ Q+E D E+ R Q + E Q I + +
Sbjct: 279 QREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE-DLEQVR--QELYQEEQAEIYKSK 335
Query: 245 ELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYM-EQLQEEDLKDMER 303
++ E+++R ++++ + E+ + L+ + ++E+E + M + E+D ++
Sbjct: 336 --LKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
Query: 304 RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER--- 360
Q+Q++K Q E +R A EKL ++ +F K E++ +Q R
Sbjct: 394 AQKQRMK-QLEHRR-------------AVEKLIEERRQQFLADKQRELEEWQLQQRRQGF 439
Query: 361 IRREKEKEIARLRAMQEKA 379
I E+E RL+ ++E A
Sbjct: 440 INAIIEEE--RLKLLKEHA 456
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 108 bits (270), Expect = 1e-23
Identities = 101/395 (25%), Positives = 183/395 (46%), Gaps = 21/395 (5%)
Query: 136 EATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMS 195
+A DA ++ +QKE K+ ++ E K + R K R E +D
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRK-RDRHRERQRDRE 102
Query: 196 KIILNAKCHAIRDAQILEKQQIQKELDTEEKR-----LDQMMEVERQKSIQRQEELERKR 250
K + RD Q +++ QKE + E +R D+ + +R++ QR E ER+R
Sbjct: 103 KE-RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161
Query: 251 REERIRGR-----RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQ 305
+ +R R R RQ + EKN++ER QRE+E + + E+ +E + ++ E
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE-RERETET 220
Query: 306 QQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREK 365
+ + K Q + +R +++ E A+ + A + E K+ RE E + +++R RR+K
Sbjct: 221 ETERKRQTDRERDRQRKTEREREKQAERERASERETERDKE---RERERDRDRDRDRRQK 277
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAEL-RKSR 424
E+E R Q + + +++ R + Q +RE R K ++ E E E R++
Sbjct: 278 ERERQTDRKRQRRTE---RDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 425 LEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRE 484
++ +E Q + DR+ + R R Q E+ER E ++ + E R
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 485 NQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
++QKE + + +G+R + E Q+ RE+ E +R
Sbjct: 395 DRQKERERQTEKDRDGQR-ETEKQREREKDRESER 428
Score = 101 bits (252), Expect = 2e-21
Identities = 88/335 (26%), Positives = 166/335 (49%), Gaps = 32/335 (9%)
Query: 213 EKQQIQKELDTEEKR---LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQ 269
EK+Q ++E D + +R D+ + +R + QR E ER+R+ +R R R++ E+ + +
Sbjct: 67 EKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKE 126
Query: 270 EERSLLAE-----------QREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRI 318
ER E QRE+E+++ E + Q + ++ +R+ ++ + + E ++
Sbjct: 127 RERETEREGERGRDRQTDGQRERERQRDAEKERERQTD--RERQRQTERNRQKEREREKN 184
Query: 319 NDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAE------QERIRREKEKEIARL 372
E ++++ + + K D+ +++ RE E E E +ER R+ K +
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREK 244
Query: 373 RAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKE 432
+A +E+A + + E+D R + DR+ R+KE+E + R+ R E+ E
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK------RQRRTERDRETE 298
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQN 492
Q +R+R E ER + +RE+ E+ER E ++ T R + R++ R+ + +N
Sbjct: 299 RKRERQRERER-ERERNRKRERER-ERERERERQRETERDREKERERKRKRQTEMDRERN 356
Query: 493 RIATFEEGRRLKE-EAQKRRERIDEIKRKKLEELR 526
R T EGRR E E ++ RER + R++ E R
Sbjct: 357 R-QTGREGRRQAERERERERERDRQSAREREERER 390
Score = 99.0 bits (245), Expect = 1e-20
Identities = 97/424 (22%), Positives = 194/424 (45%), Gaps = 36/424 (8%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRA 180
RE +++ ++EK T +++ ++K+ ++ + KER + +
Sbjct: 54 RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113
Query: 181 NKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQM-MEVERQKS 239
++ R ++ K+ + + RD Q +++ +++ D E++R Q E +RQ
Sbjct: 114 DRQREKERNRQKERERET-EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE 172
Query: 240 IQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLK 299
RQ+E ER++ + R R + E+ K ++ S +RE+E+E E + Q + +
Sbjct: 173 RNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER 232
Query: 300 DMERRQQQKLKMQAEIKRIND---ENQKQKAELLAQEKLADQMVMEF------------- 343
D +R+ +++ + QAE +R ++ E K++ +++ D+ E
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 344 ----TKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVA 398
T++K R+ E E E+ER R RE+E+E R R Q + + E++ R ++ Q
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETER-DREKERERKRKRQTEM 351
Query: 399 DREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIE 458
DRE R+ R++ E E E + R Q A + +R+RD + + Q E
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSARERE------ERERDRDRDRQKERERQTE 405
Query: 459 KERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIK 518
K+R + ++ T + + R + RE+++ + R ++GR E Q R+ + K
Sbjct: 406 KDR--DGQRETEKQRE----REKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Query: 519 RKKL 522
R L
Sbjct: 460 RSTL 463
Score = 89.7 bits (221), Expect = 6e-18
Identities = 86/344 (25%), Positives = 161/344 (46%), Gaps = 33/344 (9%)
Query: 216 QIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRRE-ERIRGRRQIVEQMEKNQEERSL 274
Q K+ D +++ E RQK +R+ E + RE +R R RR+ ++ K R
Sbjct: 44 QAHKDADGDDR------ERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRE- 96
Query: 275 LAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRIND---ENQKQKAELLA 331
QR++EKE+ + + + K+ R+++++ + + E +R D + Q+++
Sbjct: 97 --RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRD 154
Query: 332 QEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRA 391
EK ++ +++ R + E E+E+ R+E+ +E R R + K +D +E+ R
Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQER-RERERQREKENKTEDRHSERGRERE 213
Query: 392 KRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRD---EFER 448
+ + + E +R+ ++ +TE E K A +E A + +RD++ E +R
Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQ-----AERERASERETERDKERERERDR 268
Query: 449 ILRAQREQIEKERLEEEK--KATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEE 506
R Q E+ER + K + T R + R + RE +++ +NR E R + E
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE 328
Query: 507 AQKR----RERIDEIKRKKLEEL-----RATGLPEKYCIEAERK 541
Q+ RE+ E KRK+ E+ R TG + E ER+
Sbjct: 329 RQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Score = 53.5 bits (127), Expect = 5e-07
Identities = 58/234 (24%), Positives = 98/234 (41%), Gaps = 23/234 (9%)
Query: 108 EFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS---D 164
E ER K A RE R+ KE+E D R + K++E + ++ D
Sbjct: 239 EREREKQAE----RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERD 294
Query: 165 LEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTE 224
E K Q +R + ++E E + + + R+ + K++ Q E+D E
Sbjct: 295 RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE 354
Query: 225 EKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKE 284
R + + +RQ E ER+R ER RQ + E+ + +R R++E+E
Sbjct: 355 RNR-------QTGREGRRQAERERERERER---DRQSAREREERERDRD---RDRQKERE 401
Query: 285 QMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQ 338
+ E Q E K ER + ++ + E R E +KQK +E+ D+
Sbjct: 402 RQTEKDRDGQRETEKQREREKDRESERGRERGR---EREKQKGRERDRERQTDR 452
Score = 50.8 bits (120), Expect = 3e-06
Identities = 45/201 (22%), Positives = 93/201 (46%), Gaps = 11/201 (5%)
Query: 342 EFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR- 400
E +++ +A +A+ + R ++KE R R ++ ++ +++ R K DR
Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRH 94
Query: 401 EWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKE 460
R++++E R++ R+ E+ KE + + +R +R QRE+ +
Sbjct: 95 RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR-DRQTDGQRERERQR 153
Query: 461 RLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRK 520
E+E++ Q E +RQ N+QKE + E+ R+ + E +++RE+ ++ + +
Sbjct: 154 DAEKERER----QTDRERQRQTERNRQKERER-----EKNRQERRERERQREKENKTEDR 204
Query: 521 KLEELRATGLPEKYCIEAERK 541
E R + E ERK
Sbjct: 205 HSERGRERERERETETETERK 225
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 108 bits (270), Expect = 1e-23
Identities = 86/368 (23%), Positives = 195/368 (52%), Gaps = 39/368 (10%)
Query: 87 VRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKE---ATMDAVM 143
++E + E E + E +++ A +L +++L+A KE + A + A +
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273
Query: 144 TRKKI-----MKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE-----EELKD 193
++ +Q+E +W +K+ + EE +E+ + + ++ K+R ++E EE
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 194 MSKIILNAKCHAIRDAQILEKQQIQKEL-DTEEKRLDQMMEVERQKSIQRQEELERKRRE 252
+ ++ K IR+ + EK Q+++ + EEKR ++ E R++ ++++E + R+E
Sbjct: 334 RQEEMMWEKEEKIRELE--EKMHEQEKIREQEEKRQEE--EKIREQEKRQEQEAKMWRQE 389
Query: 253 ERIRGRRQIVEQMEKNQEERSLLAEQRE---QEKEQMLEYMEQLQEEDLKDMERRQQQKL 309
E+IR EQ EK +E+ ++ EQ E +++E+M E E++QE++ K RRQ++K+
Sbjct: 390 EKIR------EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK--MRRQEEKI 441
Query: 310 KMQAEIKRINDENQKQKAELL--AQEKLADQ--------MVMEFTKKKMAREAEFEAEQE 359
+ Q + R +E +++ E++ +EK+ +Q M+ ++KM R+ E EQE
Sbjct: 442 REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE 501
Query: 360 RIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAE 419
+ RE+E++I M ++ ++ EQ+ ++ +++ ++E + + +E ++ E
Sbjct: 502 KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR 561
Query: 420 LRKSRLEQ 427
++ ++++
Sbjct: 562 QQEEKMQE 569
Score = 107 bits (268), Expect = 2e-23
Identities = 101/449 (22%), Positives = 221/449 (49%), Gaps = 57/449 (12%)
Query: 114 WASHVLTREELEARDQA--------FKKEKEATMDAVMTRKK--------IMKQKEMVWN 157
++ H + + E EARD F E E + AV T+KK + K+++ +
Sbjct: 136 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL 195
Query: 158 NNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSKIILNAKCHAIRDAQILEK 214
+ + +E KE+ L ++ + E+ E +K++ + + AK +L +
Sbjct: 196 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKL-------LLPQ 248
Query: 215 QQIQKELDTEEKRLDQMMEVERQKSIQRQE---ELERKRREERIRGRRQIVEQMEKNQEE 271
QQ+Q E D K L Q + + Q ++ E L +++ E+ R +I E+ EK QE+
Sbjct: 249 QQLQAEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ 307
Query: 272 RSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLA 331
+ EQ E+ + Q E++ E + M R+++ + + +I+ + ++ +Q+
Sbjct: 308 EEKIREQEEKMRRQ-----EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 362
Query: 332 QEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRA 391
+EK ++ + +K+ +EA+ ++E+IR E+E++I M ++ ++ EQ+
Sbjct: 363 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 392 KRNQEVADREWR-RKEKENAR----------KKMETEAELRKSRLEQVAFKEHALAVQVQ 440
++ +E+ ++E + R+++E R +K+ + E+ + + E++ +E + Q
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 441 RDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQK--EVQNRIATFE 498
+ +++ E+ +R Q E+I E+EKK + + E ++E ++K E + ++ E
Sbjct: 482 KMQEQEEK-MRRQEEKIR----EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 536
Query: 499 EGRRLKEEAQKRRE---RIDEIKRKKLEE 524
E + +EE +R+E R E++ ++ EE
Sbjct: 537 EKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Score = 103 bits (256), Expect = 5e-22
Identities = 78/287 (27%), Positives = 163/287 (56%), Gaps = 25/287 (8%)
Query: 110 ERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRK--KIMKQKEMVWNNNKKLSDLEE 167
E+I+ + +E + R+Q +EK + +M K K+ +Q+EM+W +K+ +LEE
Sbjct: 295 EKIQEREEKIQEQEEKIREQ---EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 168 VAKERA-----QNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELD 222
E+ + Q K+R EQE+ + +K+ + ++ +I E++++ +E
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE-- 408
Query: 223 TEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR-RQIVEQMEKNQEERSLLAEQREQ 281
EEK +Q ++ Q+ +++E + +R+EE+IR + ++I EQ EK +E+ ++ EQ E+
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 282 EKEQ---MLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQ 338
EQ M E ++QE++ K RRQ++K++ Q + R +E +++ E++ ++ ++
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEK--MRRQEEKIREQEKKIREQEEKIREQEEMMQEQ---EE 523
Query: 339 MVMEFTKKKMAREAEFEAEQERIRREKEK---EIARLRAMQEKAQDY 382
+ E +K +E + + ++E++RR++EK + RLR +EK Q++
Sbjct: 524 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 55.8 bits (133), Expect = 1e-07
Identities = 71/322 (22%), Positives = 140/322 (43%), Gaps = 30/322 (9%)
Query: 222 DTEEKRLDQMMEVERQKS--IQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQR 279
DT++K+++ E S E+ ++ + + RR++ Q+ Q R L ++
Sbjct: 72 DTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQV---QTIRILTCQKT 128
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQM 339
E QM Y Q +K +E + + + + E ++ + + Q+K AD+
Sbjct: 129 EL---QMALYYSQ---HAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRY 182
Query: 340 VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVAD 399
+ E TK++ A E KEK +QEK Q ++E+ ++ N +
Sbjct: 183 IEELTKERDALSLELYRNTITDEELKEKNAK----LQEKLQLVESEKSEIQL--NVKELK 236
Query: 400 REWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEK 459
R+ R + +++++ EA+ L+ V+ K +Q Q + +E L Q+E+
Sbjct: 237 RKLERAKLLLPQQQLQAEADHLGKELQSVSAK-----LQAQVEENELWNRLNQQQEE--- 288
Query: 460 ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
+ +E+K R + E ++RE ++K + +E KEE +R+E + K
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE-----KEEKMRRQEEMMWEKE 343
Query: 520 KKLEELRATGLPEKYCIEAERK 541
+K+ EL ++ E E K
Sbjct: 344 EKIRELEEKMHEQEKIREQEEK 365
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 102 bits (253), Expect = 1e-21
Identities = 84/279 (30%), Positives = 148/279 (53%), Gaps = 38/279 (13%)
Query: 236 RQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQE 295
++K QR E L RK E++R R+++ E + EE L E+R ++ Q E +EQ++E
Sbjct: 531 KEKERQRLENLRRKEEAEQLR-RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 589
Query: 296 EDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFE 355
E K +E++ Q I+++ +K K E LA+EK KKK A + +
Sbjct: 590 EKKKQIEQKFAQ----------IDEKTEKAKEERLAEEK---------AKKKAAAK---K 627
Query: 356 AEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKME 415
E+ RR++E+E RLR +Q++ ++ + Q+ L+ K+ +E +E RK E R +
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEE-RRHQELLQKKKEEE---QERLRKAAEAKRLAEQ 683
Query: 416 TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQ-- 473
E E R+ + +E + +++R E ER L Q + E+ERL+ E++ R +
Sbjct: 684 REQERREQERREQERREQE---RREQERREQERQLAEQERRREQERLQAERELQEREKAL 740
Query: 474 --HANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKR 510
+L+R++ E ++KE Q R+A R+L+EE +K+
Sbjct: 741 RLQKEQLQRELEEKKKKEEQQRLAE----RQLQEEQEKK 775
Score = 82.8 bits (203), Expect = 7e-16
Identities = 66/293 (22%), Positives = 146/293 (49%), Gaps = 34/293 (11%)
Query: 133 KEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVA---KERAQNLLQRANKLRMEQEE 189
KEKE + RK+ +Q K LEEV +ER + +LQ ++ +EE
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 190 ELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERK 249
+ K + + + AQI EK + KE E++ +++ + ++ EE+E +
Sbjct: 591 KKKQIEQ----------KFAQIDEKTEKAKEERLAEEK------AKKKAAAKKMEEVEAR 634
Query: 250 RREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKL 309
R++E R + ++Q E+ + + LL +++E+E+E++ + E + + ++ ERR+Q++
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 310 KMQA-EIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKE 368
+ + E +R E ++Q+ +L QE+ +Q +++ E E + ++ +R +KE+
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQ-------ERLQAERELQEREKALRLQKEQ- 746
Query: 369 IARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELR 421
+Q + ++ + +++ R Q ++E + KE A K + +++
Sbjct: 747 ------LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQ 793
Score = 80.9 bits (198), Expect = 3e-15
Identities = 72/299 (24%), Positives = 150/299 (50%), Gaps = 36/299 (12%)
Query: 152 KEMVWNNNKKLSDLEEVAKERAQNLLQR--ANKLRMEQEEELKDMSKIILNAKCHAIRDA 209
K + N D +E ++R +NL ++ A +LR ++ EE K + +
Sbjct: 517 KSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE----------DKRRRLEEV 566
Query: 210 QILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQ----EELERKRREERIRGRRQIVEQM 265
++ +++++K L E R++QM E E++K I+++ +E K +EER+ + +
Sbjct: 567 KLKREERLRKVLQARE-RVEQMKE-EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 624
Query: 266 EKNQEERSLLAEQREQEKEQMLEYMEQLQEED-----LKDMERRQQQKLKMQAEIKRIND 320
K EE + A ++++E+ + L +++Q +EE L+ + +Q++L+ AE KR+ +
Sbjct: 625 AKKMEE--VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
+ ++++ E QE+ E +++ R + EQER E+E+ + R E+
Sbjct: 683 QREQERRE---QER------REQERREQERREQERREQERQLAEQERRREQERLQAER-- 731
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ Q + ALR ++ Q + E ++K++E R E ++ + ++ A AL V V
Sbjct: 732 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTV 790
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/211 (24%), Positives = 108/211 (51%), Gaps = 15/211 (7%)
Query: 121 REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS---DLEEVAKERAQNLL 177
RE +E + KK+ E + + + K++ + KK + +EEV R Q
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE-- 638
Query: 178 QRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQ 237
+ A +LR Q+EE + + +L K E++Q + E KRL + E ER+
Sbjct: 639 EEARRLRWLQQEEEERRHQELLQKK---------KEEEQERLRKAAEAKRLAEQREQERR 689
Query: 238 KSIQR-QEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEE 296
+ +R QE E++RRE+ R + + + + E+ +E+ L AE+ QE+E+ L ++ +
Sbjct: 690 EQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749
Query: 297 DLKDMERRQQQKLKMQAEIKRINDENQKQKA 327
+L++ +++++Q+ + +++ ++ K+ A
Sbjct: 750 ELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
Score = 61.6 bits (148), Expect = 2e-09
Identities = 65/269 (24%), Positives = 129/269 (47%), Gaps = 56/269 (20%)
Query: 258 RRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKR 317
+R +M+ ++ER L R +E+ EQL+ + +++ +RR+ +++K++ E
Sbjct: 521 KRNTPLRMDPKEKERQRLENLRRKEEA------EQLRRQKVEEDKRRRLEEVKLKRE--- 571
Query: 318 INDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQE 377
++ + L A+E++ +QM E KK E +F E+ + KE+ +A +A ++
Sbjct: 572 -----ERLRKVLQARERV-EQMKEE---KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 622
Query: 378 KAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAV 437
A AK+ +EV E RRK++E AR+ + E + R +++ K+
Sbjct: 623 AA-----------AKKMEEV---EARRKQEEEARRLRWLQQEEEERRHQELLQKKK---- 664
Query: 438 QVQRDRDEFERILRAQR--EQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIA 495
+ +++ + A+R EQ E+ER E+E+ RE +++E + R
Sbjct: 665 --EEEQERLRKAAEAKRLAEQREQERREQER----------------REQERREQERREQ 706
Query: 496 TFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
E R E ++RRE+ ++L+E
Sbjct: 707 ERREQERQLAEQERRREQERLQAERELQE 735
Score = 52.8 bits (125), Expect = 8e-07
Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 20/153 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQ-AFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDL 165
EE R++W L +EE E R Q +K+KE + + +K + K + ++ +
Sbjct: 639 EEARRLRW----LQQEEEERRHQELLQKKKEEEQERL---RKAAEAKRLAEQREQERREQ 691
Query: 166 EEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQ------ILEKQQIQK 219
E +ER + +R + R EQE +L + + + A R+ Q L+K+Q+Q+
Sbjct: 692 ERREQERREQ--ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749
Query: 220 ELDTEEKRLDQMMEVERQKSIQRQEELERKRRE 252
EL+ ++K+ +Q ER Q QEE E+K +E
Sbjct: 750 ELEEKKKKEEQQRLAER----QLQEEQEKKAKE 778
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1646
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1647 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1701
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1762 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1821 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1879 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2053
Query: 543 N 543
+
Sbjct: 2054 H 2054
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1539
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1540 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1588 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1643
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1694
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1695 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1804
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1865 RLRRLAED 1872
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1794
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2209 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2306
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2228
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2347
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2403
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2579
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2580 RRQQEELLA 2588
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2267 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2505 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2557 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2616 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1516
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1231 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1590 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1698
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1134 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1191 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1303
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1420
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1421 ----ELQQLRQSSEAE 1432
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1650
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1651 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1705
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1765
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1766 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1825 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1882
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1883 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2057
Query: 543 N 543
+
Sbjct: 2058 H 2058
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1543
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1544 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1592 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1647
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1698
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1699 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1808
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1809 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1869 RLRRLAED 1876
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1798
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1858
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1859 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1918
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1919 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2035
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2036 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2095
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2213 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2310
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2232
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2351
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2407
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2528 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2583
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2584 RRQQEELLA 2592
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2271 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2509 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2561 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2620 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2670
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1520
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1521 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1235 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1594 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1702
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1137
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1138 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1194
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1195 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1253 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1307
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1366
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1424
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1425 ----ELQQLRQSSEAE 1436
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1646
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1647 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1701
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1762 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1821 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1879 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2053
Query: 543 N 543
+
Sbjct: 2054 H 2054
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1539
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1540 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1588 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1643
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1694
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1695 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1804
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1865 RLRRLAED 1872
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1794
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2209 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2306
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2228
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2347
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2403
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2579
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2580 RRQQEELLA 2588
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2267 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2505 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2557 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2616 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1516
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1231 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1590 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1698
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1134 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1191 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1303
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1420
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1421 ----ELQQLRQSSEAE 1432
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1614
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1615 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1669
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1729
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1730 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1789 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1846
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1847 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2021
Query: 543 N 543
+
Sbjct: 2022 H 2022
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1507
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1508 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1556 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1611
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1662
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1663 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1772
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1833 RLRRLAED 1840
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1762
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1822
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1823 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1882
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1883 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 1999
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2000 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2059
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2177 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2274
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2196
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2315
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2371
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2491
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2492 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2547
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2548 RRQQEELLA 2556
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2235 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2473 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2525 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2584 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2634
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1484
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1485 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1199 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1558 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1666
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1102 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1158
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1159 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1217 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1271
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1330
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1388
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1389 ----ELQQLRQSSEAE 1400
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1783
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1784 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1838
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1899 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1958 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 2015
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 2016 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2190
Query: 543 N 543
+
Sbjct: 2191 H 2191
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1676
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1677 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1725 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1780
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1831
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1832 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1941
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1942 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 2002 RLRRLAED 2009
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1931
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1992 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 2051
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 2052 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2168
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2169 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2346 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2443
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2365
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2484
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2540
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2661 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2716
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2717 RRQQEELLA 2725
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2404 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2642 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2694 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2753 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2803
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1653
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1654 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1368 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1727 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1835
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1270
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1271 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1327
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1328 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1386 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1440
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1499
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1557
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1558 ----ELQQLRQSSEAE 1569
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1624
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1625 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1679
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1739
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1740 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1799 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1856
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1857 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2031
Query: 543 N 543
+
Sbjct: 2032 H 2032
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1517
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1518 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1566 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1621
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1672
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1673 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1782
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1783 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1843 RLRRLAED 1850
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1772
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1833 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1892
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1893 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2009
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2010 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2187 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2284
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2206
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2325
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2381
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2502 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2557
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2558 RRQQEELLA 2566
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2245 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2483 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2535 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2594 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2644
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1494
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1495 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1209 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1568 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1676
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1111
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1112 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1168
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1169 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1227 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1281
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1340
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1398
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1399 ----ELQQLRQSSEAE 1410
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1632
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1633 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1687
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1747
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1748 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1807 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1864
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1865 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2039
Query: 543 N 543
+
Sbjct: 2040 H 2040
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1525
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1526 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1574 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1629
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1680
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1681 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1790
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1791 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1850
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1851 RLRRLAED 1858
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1780
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1841 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1900
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1901 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2017
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2018 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2077
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2195 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2292
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2214
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2274
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2275 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2333
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2389
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2449
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2510 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2565
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2566 RRQQEELLA 2574
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2253 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2491 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2543 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2602 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2652
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1502
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1503 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1217 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1576 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1684
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1119
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1120 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1176
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1177 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1235 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1289
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1348
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1406
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1407 ----ELQQLRQSSEAE 1418
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 101 bits (251), Expect = 2e-21
Identities = 123/481 (25%), Positives = 227/481 (47%), Gaps = 62/481 (12%)
Query: 108 EFERIKWASHVLT---REELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS- 163
+ ER HV REE E R Q + + A +A ++ +++ ++ N +L
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRL 1673
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ---QIQKE 220
EEVA++++ + A K + E E E + K A+ A+R ++ E++ Q Q
Sbjct: 1674 QAEEVAQQKSLAQAE-AEKQKEEAEREARRRGK----AEEQAVRQRELAEQELEKQRQLA 1728
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERI-RGRRQIVEQMEKNQEERSLLAEQR 279
T ++RL E+ R ++ Q E +R+ EE + R +R+ +K QE + LA+ R
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1788
Query: 280 EQEKEQMLEYMEQLQEEDLKDMERRQQ-----------------------QKLKMQAEIK 316
E E +L + +EE E+ +Q ++ K Q ++
Sbjct: 1789 A-EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Query: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA---EFEAEQERIRREKEKEIARLR 373
+ Q+ +AE + EKLA + E T+ K E E EAE ER+RR E E + R
Sbjct: 1848 EEDAARQRAEAERVLAEKLA--AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1905
Query: 374 AMQEKAQDYQAEQDALRAKRNQEVADREWRRKE---KENARKKMETEAELR--KSRLEQV 428
++E+A ++A+ + R + ++ +D E R++ ++ R++ + E E+ K+ E+
Sbjct: 1906 RLEEQAAQHKADIEE-RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 429 AFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN--- 485
A + L +++ R R E LR+ +EQ E E + + A + E +V+++
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 486 QQKEVQNRIATFEEGRRLK---EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
+++ + R A EE RLK EEA++ RER ++ ++L+ + ++AE KA
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR---LQAEEKA 2080
Query: 543 N 543
+
Sbjct: 2081 H 2081
Score = 97.4 bits (241), Expect = 3e-20
Identities = 111/428 (25%), Positives = 197/428 (46%), Gaps = 63/428 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE EA+ + ++E E V + +Q E+ + K E A+E+ Q LQ
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE--AEAAREK-QRALQALE 1566
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQ 241
+LR++ EE + +R A++ +Q+Q L+T ++ + ++ +R +
Sbjct: 1567 ELRLQAEEAER------------RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 242 RQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDM 301
+ +LER +EE + Q+ E+ E+ ++++ AE+ +E E+ LE + E L+
Sbjct: 1615 KTAQLERSLQEEHV-AVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEALR-- 1670
Query: 302 ERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERI 361
R Q +++ Q + + E QK++AE A+ + +++ R+ E AEQE
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK-------AEEQAVRQREL-AEQEL- 1721
Query: 362 RREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR---------- 411
EK++++A A Q A AEQ+ +R + E +++ + E+E AR
Sbjct: 1722 --EKQRQLAEGTAQQRLA----AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775
Query: 412 KKMETEAELRKSRLE-QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATG 470
K+ E EAEL K R E +V A A + R E + QR + E R E +
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK----QRLEAEAGRFRELAEEAA 1831
Query: 471 RLQH-ANELRRQ----------VRENQQKEVQNRIATFEEGRRLKEEAQ---KRRERIDE 516
RL+ A E +RQ R ++ + ++A E RLK EA+ K +E +E
Sbjct: 1832 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1891
Query: 517 IKRKKLEE 524
R+ E+
Sbjct: 1892 RLRRLAED 1899
Score = 95.1 bits (235), Expect = 1e-19
Identities = 130/580 (22%), Positives = 252/580 (43%), Gaps = 73/580 (12%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLT 68
L +AA+ + R + V +E++ L ++ + +S S + K L+
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE----KSKQRLEAEAG 1821
Query: 69 ALG-LDRKPETIQLITRDMVRELIVPTEDPS---GESLIISPEEFERIKWASHVLTREEL 124
L + ++ + + R+ + ED + E+ + E+ I A+ + T E+
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
Query: 125 EARDQAFKKEKEATM--DAVMTRKKIMKQ----KEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+++ + E+ + D R+++ +Q K + +L + ER + L++
Sbjct: 1882 ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1941
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQI-LEKQQIQKEL-DTEEKRLDQMMEVER 236
+ R + EEE+ + A A A++ LE +I+ DT + +E R
Sbjct: 1942 DTLRQRRQVEEEILALKASFEKA---AAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998
Query: 237 QKSIQRQEELERKRREERI-----------RGRRQIVEQMEK---NQEERSLLAEQREQE 282
Q+ + +EE R+ EER+ R R+ +E++E+ EE L E+ EQE
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2058
Query: 283 KEQMLEYMEQ-----LQEED------LKDMERRQQQKLKMQAEI-----------KRIND 320
+ L+ ++ LQ E+ ++ E+ QQ L+ + + +R +
Sbjct: 2059 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQ 380
E ++ + + + + + V E + K + E E Q R + + E R A QE A+
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 381 DYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSR--LEQVAFKEHALAVQ 438
QAEQ ALR K+ + + ++ ++ R+K + E EL R LE+ +++ L +
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 439 VQRDRDEFERILRAQREQIEKE------RLEEEKKATGRLQHANE-LRRQVRENQQK--- 488
+QR + E R QR Q+E+E ++EE K R++ N L + ++N Q+
Sbjct: 2236 LQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294
Query: 489 -EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRA 527
E + EE RL AQ+ R+ ++ + L + RA
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRA 2333
Score = 92.8 bits (229), Expect = 7e-19
Identities = 125/489 (25%), Positives = 228/489 (46%), Gaps = 80/489 (16%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAV---MTRKKIMKQKEMVWNNNKKLS 163
EE ER+K ++ + +A+ A K KEA +A + ++QK+ +K
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 164 DLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILE----KQQIQK 219
E + + Q LR++ EE D K +L+ + ++ A+ E + Q+++
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEET--DHQKNLLDEELQRLK-AEATEAARQRSQVEE 2255
Query: 220 ELDTEEKRLDQM------MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK----NQ 269
EL + +++++ +E E + I R ++ ++ +E +Q+ E+ + Q
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315
Query: 270 EERSL-------LAEQREQEKEQMLEYMEQLQEED-LK-DMERRQQQKLKMQAEIKRIND 320
E L LA+QR ++ + E M+ +QE LK + E QQQK Q + +R+
Sbjct: 2316 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ- 2374
Query: 321 ENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR-REKEKEIARLRAMQEKA 379
E+++Q A+ LA+E Q +E ++ R+ E AE ER++ R E A+ RA +E A
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQARA-EEDA 2430
Query: 380 QDY--QAEQ-------------------DALRAKRNQEVADREWRRK---EKENARKKME 415
Q + QAE+ L +R Q D E R+ E E ++K++
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
Query: 416 TEAELRKSRLEQV-AFKEHALAVQVQRDRDEF--ERILRAQREQ-IEKERLEEEKKATGR 471
EA+L + + E++ ++ L + Q + F E+ QRE+ IE+E+ + E+
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2550
Query: 472 LQHANELRRQVRENQQKEVQNR---IATFEEGR----------RLKEEAQKRRERIDEIK 518
+ A +LR + + QQ+ Q R +A+ EE R R K+E ++ E+ +
Sbjct: 2551 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ----Q 2606
Query: 519 RKKLEELRA 527
R++ EEL A
Sbjct: 2607 RRQQEELLA 2615
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/478 (23%), Positives = 209/478 (43%), Gaps = 55/478 (11%)
Query: 107 EEFERIKWASHVLTREELEARDQAF------------KKEKEATMDAVMTRKKIMKQKEM 154
EE +R+K + R+ + ++ F K EA A++ R K Q+ +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEEL---KDMSKIILNAKCHAIRDAQI 211
K EE A R Q A +LR EE+L + +++ +L K A+++A
Sbjct: 2294 QEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 212 LEKQ----QIQKELDTEEKRL-----DQMME--------VERQKSIQRQEELERKRREER 254
L+ + Q QKEL E+ R +QM + +R +RQ +LE ER
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 255 IRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
++ R + + + EE + ++ +E + L E +E + ++ + Q+ + +
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 315 IKRIND---ENQKQKAELLAQEKLADQMVMEF-TKKKMAREAEFEAEQERIRREKEKEIA 370
+R+ + E +++K +L + KL E T ++ E +A Q+ EK+ +
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 371 RLRAM-QEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
R R + QEKA+ Q QD EVA + R+E++ +++ME E + + +E+
Sbjct: 2532 RERFIEQEKAKLEQLFQD--------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
++H V+R ++E ++ L QR Q E+ EE ++ +LQ E R + ++
Sbjct: 2584 RRQHEAEEGVRRKQEELQQ-LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Query: 490 VQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPA 547
+++A + R+ +D + E GL K + ++A IL A
Sbjct: 2643 TASQVAA-------TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2693
Score = 86.3 bits (212), Expect = 7e-17
Identities = 86/338 (25%), Positives = 160/338 (47%), Gaps = 36/338 (10%)
Query: 238 KSIQRQEELERKRREERIRGRRQIVE---QMEKNQEERSLLAEQREQEKEQMLEYMEQLQ 294
++++R EE ER ++R R ++ E +EK ++ A+ + Q + + E +++Q
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 295 EEDLKDMER---RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
EE ++ E QQQK +Q E++++ ++ + Q + A++ + ++
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 352 AEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKE-- 408
+ EA E++R E E + R RA + +AQ QA+++A R +R +V D R+++ E
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR--QVQDESQRKRQAEVE 1543
Query: 409 -NARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
+R K E EA K R Q A +E L + R + RA++ Q+ E + +
Sbjct: 1544 LASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 468 ATGRLQHAN------ELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRRER-- 513
A + + A+ +L R ++E ++E + R E R +EEA++ ER
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 514 --IDEIKRKKL-------EELRATGLPEKYCIEAERKA 542
+E R +L ++ A EK EAER+A
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/476 (23%), Positives = 215/476 (45%), Gaps = 64/476 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ-----KEMVWNNNKK 161
E+ + + A RE+L ++QA +E E + V ++ KQ K+
Sbjct: 1258 EQIQAMPLADSQAVREQLR-QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316
Query: 162 LSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD-AQILEKQQIQKE 220
+ LE VA + +Q ++ +++ +L+ + I+ ++ L + + ++
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEE------RSL 274
L +++ ++ E + ++++Q +L + + + R+ E ++ QEE ++
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436
Query: 275 LAEQREQEKEQMLEYMEQLQEEDL----KDMERRQQQKLKMQAEIKRIN-----DENQKQ 325
A+Q+++ ++ L+ + Q E ++ + E ++ +L+++ EI+ + E Q+
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAE-----FEAEQERIRREKEKEIARLRAMQEKAQ 380
AE Q A E K++ EAE + E +R R+ + + +R++A E A+
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 381 DYQAEQDALRAKRNQ-EVADREWRRKEKENARK--------KMETEAELRKSR------- 424
+ Q AL R Q E A+R R+ E E AR+ + EAEL+ R
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 425 --LEQVAFKEHALAVQVQRDRDEFERILRAQRE-QIEKERLEEEKKATGRLQHANE---L 478
LE+ +EH Q+ R+E ER RAQ++ + E+ R E E++ ANE L
Sbjct: 1617 AQLERSLQEEHVAVAQL---REEAER--RAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 479 RRQVRENQQK--------EVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELR 526
R Q E Q+ E Q A E RR K E Q R+R E+ ++LE+ R
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR--ELAEQELEKQR 1725
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/376 (22%), Positives = 167/376 (44%), Gaps = 37/376 (9%)
Query: 177 LQRANKLRMEQEEELKDMSKIILNAK----CHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
L++ L E+LK +S +I + + Q+ E Q + L E +
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1160
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
++ Q Q Q + R E +RG +++ E++++ ER + E+ + Q+LE +
Sbjct: 1161 KLRAQAEAQ-QPTFDALRDE--LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1217
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRIND-------ENQKQKAELLAQEKLAD-QMVMEFT 344
+ + D+ +R+ ++L Q R + ++ +++ E + LAD Q V E
Sbjct: 1218 VLAQ--TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275
Query: 345 KKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404
+++ A E E E++ + + A+ +DY+ + +A+ + VA +
Sbjct: 1276 RQEQALLEEIERHGEKVEECQRFAKQYINAI----KDYELQLVTYKAQL-EPVASPAKKP 1330
Query: 405 KEKENARKKMETEAELRK--SRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL 462
K + + ++ +LR S L + + + R +E ER+ QR + E+ERL
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1389
Query: 463 EEEKKATGRLQHANELRRQVR---ENQQKEVQNRIATFEEGRRLKE---EAQKRRERIDE 516
E + A + + E Q + E + KE+Q R+ EE R +E +AQ+++ I E
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQE 1447
Query: 517 IKRKKLEELRATGLPE 532
+L++LR + E
Sbjct: 1448 ----ELQQLRQSSEAE 1459
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 97.8 bits (242), Expect = 2e-20
Identities = 81/280 (28%), Positives = 151/280 (53%), Gaps = 40/280 (14%)
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
E +R ++++R+EE E+ RR+ ++ E + EE L E+R ++ Q E +EQ
Sbjct: 538 ERQRLENLRRKEEAEQLRRQ-------KVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
++EE K +E++ Q I+++ +K K E LA+EK KKK A +
Sbjct: 591 MKEEKKKQIEQKFAQ----------IDEKTEKAKEERLAEEK---------AKKKAAAK- 630
Query: 353 EFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARK 412
+ E+ RR++E+E RLR +Q++ ++ + Q+ L+ K+ +E +E RK E R
Sbjct: 631 --KMEEVEARRKQEEEARRLRWLQQEEEE-RRHQELLQKKKEEE---QERLRKAAEAKRL 684
Query: 413 KMETEAELRKSRLEQVAFKEHALAVQVQRDRDE--FERILRAQREQIEKERLEEEKKATG 470
+ E E R+ + +E Q +R+++ E+ R ++E+++ ER +E++
Sbjct: 685 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 744
Query: 471 RLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKR 510
RLQ +L+R++ E ++KE Q R+A R+L+EE +K+
Sbjct: 745 RLQ-KEQLQRELEEKKKKEEQQRLAE----RQLQEEQEKK 779
Score = 94.4 bits (233), Expect = 2e-19
Identities = 91/315 (28%), Positives = 161/315 (51%), Gaps = 59/315 (18%)
Query: 237 QKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEE 296
+K QR E L RK E++R R+++ E + EE L E+R ++ Q E +EQ++EE
Sbjct: 536 EKERQRLENLRRKEEAEQLR-RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 297 DLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEA 356
K +E++ Q I+++ +K K E LA+EK KKK A + +
Sbjct: 595 KKKQIEQKFAQ----------IDEKTEKAKEERLAEEK---------AKKKAAAK---KM 632
Query: 357 EQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMET 416
E+ RR++E+E RLR +Q++ ++ +R+QE+ +K+KE ++++
Sbjct: 633 EEVEARRKQEEEARRLRWLQQEEEE----------RRHQELL-----QKKKEEEQERLRK 677
Query: 417 EAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHAN 476
AE ++ LA Q +++R E E R ++E+ E+ER E+E++ R
Sbjct: 678 AAEAKR------------LAEQREQERREQE---RREQERREQERREQERREQERQLAEQ 722
Query: 477 ELRR-QVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYC 535
E RR Q R ++E+Q R E+ RL++E Q +RE ++ K+++ + L L E+
Sbjct: 723 ERRREQERLQAERELQER----EKALRLQKE-QLQRELEEKKKKEEQQRLAERQLQEEQE 777
Query: 536 IEAERKANILPATSV 550
+A+ A A +V
Sbjct: 778 KKAKEAAGASKALNV 792
Score = 82.0 bits (201), Expect = 1e-15
Identities = 69/324 (21%), Positives = 155/324 (47%), Gaps = 34/324 (10%)
Query: 102 LIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKK 161
++++P R S + L + EKE + RK+ +Q K
Sbjct: 504 MLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDK 563
Query: 162 LSDLEEVA---KERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQ 218
LEEV +ER + +LQ ++ +EE+ K + + + AQI EK +
Sbjct: 564 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ----------KFAQIDEKTEKA 613
Query: 219 KELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQ 278
KE E++ +++ + ++ EE+E +R++E R + ++Q E+ + + LL ++
Sbjct: 614 KEERLAEEK------AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 667
Query: 279 REQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQA-EIKRINDENQKQKAELLAQEKLAD 337
+E+E+E++ + E + + ++ ERR+Q++ + + E +R E ++Q+ +L QE+ +
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 727
Query: 338 QMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEV 397
Q +++ E E + ++ +R +KE+ +Q + ++ + +++ R Q
Sbjct: 728 Q-------ERLQAERELQEREKALRLQKEQ-------LQRELEEKKKKEEQQRLAERQLQ 773
Query: 398 ADREWRRKEKENARKKMETEAELR 421
++E + KE A K + +++
Sbjct: 774 EEQEKKAKEAAGASKALNVTVDVQ 797
Score = 79.0 bits (193), Expect = 1e-14
Identities = 71/281 (25%), Positives = 143/281 (50%), Gaps = 30/281 (10%)
Query: 168 VAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKR 227
V KER QR LR ++E E K+ + K + + ++ +++++K L E R
Sbjct: 535 VEKER-----QRLENLRRKEEAEQLRRQKVEED-KRRRLEEVKLKREERLRKVLQARE-R 587
Query: 228 LDQMMEVERQKSIQRQ----EELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEK 283
++QM E E++K I+++ +E K +EER+ + + K EE + A ++++E+
Sbjct: 588 VEQMKE-EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE--VEARRKQEEE 644
Query: 284 EQMLEYMEQLQEED-----LKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQ 338
+ L +++Q +EE L+ + +Q++L+ AE KR+ ++ ++++ E QE+
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE---QER---- 697
Query: 339 MVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVA 398
E +++ R + EQER E+E+ + R E+ + Q + ALR ++ Q
Sbjct: 698 --REQERREQERREQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQR 753
Query: 399 DREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ E ++K++E R E ++ + ++ A AL V V
Sbjct: 754 ELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTV 794
Score = 62.4 bits (150), Expect = 1e-09
Identities = 67/285 (23%), Positives = 127/285 (44%), Gaps = 65/285 (22%)
Query: 240 IQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLK 299
I+R L + + RQ +E + + +E L ++ E++K + LE ++ +EE L+
Sbjct: 520 IKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR 579
Query: 300 DMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQE 359
+ L+ + ++++ +E +KQ + AQ + E T+K A++E
Sbjct: 580 KV-------LQARERVEQMKEEKKKQIEQKFAQ-------IDEKTEK---------AKEE 616
Query: 360 RIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAE 419
R+ EK K+ A + M+E + E++A R + Q+ + E RR ++ +KK E +
Sbjct: 617 RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ--EEEERRHQELLQKKKEEEQER 674
Query: 420 LRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELR 479
LRK+ E +R+ EQ E+ER E+E+
Sbjct: 675 LRKAA--------------------EAKRLA----EQREQERREQER------------- 697
Query: 480 RQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
RE +++E + R E R E ++RRE+ ++L+E
Sbjct: 698 ---REQERREQERREQERREQERQLAEQERRREQERLQAERELQE 739
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 94.7 bits (234), Expect = 2e-19
Identities = 104/448 (23%), Positives = 198/448 (44%), Gaps = 49/448 (10%)
Query: 111 RIKWASHVLTREELEARD--QAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEV 168
R+K L+R+ R+ +A + A +D ++ KK++ +K +
Sbjct: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEK---------CEAVVAE 651
Query: 169 AKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKE-----LDT 223
K+ Q +R + + + E E+K + K +++A A R+ I EK + KE L+
Sbjct: 652 LKQEDQRCTERVAQAQAQHELEIKKL-KELMSATEKARREKWISEKTKKIKEVTVRGLEP 710
Query: 224 EEKRL--DQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQ 281
E ++L EV R KS+ E L+ R + R RQ E E+ + E+ L +Q +
Sbjct: 711 EIQKLIARHKQEVRRLKSLHEAELLQSDERASQ-RCLRQAEELREQLEREKEALGQQERE 769
Query: 282 EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVM 341
Q + + L++E ++RQ+ ++ E +R+ + +Q+AEL E+L Q+
Sbjct: 770 RARQ--RFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAEL---EELRQQLEE 824
Query: 342 EFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADRE 401
+ A AEFE +E R + E+ L+ Q + E+ A A R
Sbjct: 825 SSSALTRALRAEFEKGREEQERRHQMELNTLK------QQLELERQAWEAGRT------- 871
Query: 402 WRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERI----LRAQREQI 457
R++E ++ E E+RK R +++ H L + ++E E+ ++ R++
Sbjct: 872 -RKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKY 930
Query: 458 EKERLEEEKKATGRLQHANELRRQVRENQ------QKEVQNRIATFEEGRRLKEEAQKRR 511
E E E E+ + +EL+ Q+ E + Q V+ + E+ + + E+ R
Sbjct: 931 EAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSER 990
Query: 512 ERIDEIKRKKLEELRATGLPEKYCIEAE 539
+ ++ R++ E+ A E +AE
Sbjct: 991 SNLAQVIRQEFEDRLAASEEETRQAKAE 1018
Score = 80.9 bits (198), Expect = 3e-15
Identities = 98/371 (26%), Positives = 172/371 (46%), Gaps = 69/371 (18%)
Query: 207 RDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQME 266
+ A +L ++ + ++ D +R+ E +K++ RQ + +R+ E I+ ++Q+
Sbjct: 581 KQAMLLLQRALAQQRDLTARRVK-----ETEKALSRQLQRQREHYEATIQRHLAFIDQLI 635
Query: 267 KNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRIND------ 320
E++ +L+E+ E + +L++ED + ER Q + + + EIK++ +
Sbjct: 636 ---EDKKVLSEKCEA-------VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
Query: 321 ---------ENQKQKAELLAQ------EKLADQMVMEFTKKKMAREAEF----------- 354
E K+ E+ + +KL + E + K EAE
Sbjct: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRC 745
Query: 355 --EAEQERIRREKEKEI----ARLRAMQEKAQDYQAEQDALRAKRNQ---EVADREWRRK 405
+AE+ R + E+EKE R RA Q Q + EQ AL+ +R + EVA+ E R
Sbjct: 746 LRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAE-ERERL 804
Query: 406 EKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFER----ILRAQREQIEKER 461
++ AR++ E E ELR+ E + AL + ++ R+E ER L ++Q+E ER
Sbjct: 805 GQQAARQRAELE-ELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELER 863
Query: 462 LEEE-----KKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRL-KEEAQKRRE-RI 514
E K+ L ELR ++R+ + KE++ I E L KEE++K E RI
Sbjct: 864 QAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRI 923
Query: 515 DEIKRKKLEEL 525
++ K EL
Sbjct: 924 KRLRDKYEAEL 934
Score = 30.8 bits (68), Expect = 3.4
Identities = 56/284 (19%), Positives = 111/284 (39%), Gaps = 21/284 (7%)
Query: 9 LSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQS---DSPIVLLRDKHTLQK 65
L +A + R + + SS + +L + + + Q + L+ + L++
Sbjct: 804 LGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELER 863
Query: 66 TLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELE 125
G RK E L +RE I D E +I E A L +EE E
Sbjct: 864 QAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLE-------ADMALAKEESE 916
Query: 126 ARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLE-EVAKERAQNLLQRANKLR 184
++ K +A ++ + ++K ++ S+L+ ++ + +NL R L
Sbjct: 917 KAAESRIKRLRDKYEAELSELEQSERKLQ-----ERCSELKGQLGEAEGENL--RLQGLV 969
Query: 185 MEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQE 244
++E L+D + AQ++ ++ + +EE+ E+ ++ Q+ E
Sbjct: 970 RQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLE 1029
Query: 245 ELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLE 288
E RR + R++ + Q E A +R E++LE
Sbjct: 1030 LEEVHRRVKTALARKEEAVSSLRTQHE---AAVKRADHLEELLE 1070
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 93.6 bits (231), Expect = 4e-19
Identities = 86/414 (20%), Positives = 197/414 (47%), Gaps = 44/414 (10%)
Query: 146 KKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE-----EELK---DMSKI 197
++++K +E +L+++E + + LQ +L+ E E EEL+ K
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQ 911
Query: 198 ILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMME-----VERQKSIQRQEELERKRRE 252
L CH + +A++ E+++ + L E+K++ Q ++ +E ++S +++ +LE+ E
Sbjct: 912 ELEEICHDL-EARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 253 ERIRG--RRQIV--EQMEKNQEERSLLAEQ---------REQEKEQMLEYMEQLQEEDLK 299
+++ QI+ +Q K +E+ LL ++ E+EK + L ++ E +
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 300 DMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQE 359
D+E R +++ K + E+++ + + +L Q + E + +E E +A
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 360 RIRRE---KEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKME- 415
R+ E K + ++R ++ + + Q + ++ RA RN+ + +E E + ++E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 416 ------TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEK--ERLEEEKK 467
+ ELR R ++V + L + + + + + + + +E+ E+LE+ K+
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 468 ATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRE-RIDEIKRK 520
L+ A +Q EN++ E+ N + +G+ E +K+ E ++ E++ K
Sbjct: 1211 VKANLEKA----KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260
Score = 79.0 bits (193), Expect = 1e-14
Identities = 113/486 (23%), Positives = 211/486 (43%), Gaps = 92/486 (18%)
Query: 107 EEFERIKWASHVLTRE--ELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSD 164
E+ E + A H L ++ L A+ KK+ E ++ + T +++ K + + + LS
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV---KRKLQKDLEGLSQ 1399
Query: 165 LEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTE 224
E L + +L+ E ++ L D+ H + A LEK+Q
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLD--------HQRQSACNLEKKQ-------- 1443
Query: 225 EKRLDQMMEVERQKSIQRQEELERKRREERIRGRR--QIVEQMEKNQEERSLLAEQREQE 282
K+ DQ++ E+ S + EE +R E R + + + +E+ E+++ L +Q
Sbjct: 1444 -KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502
Query: 283 KEQMLEYMEQLQE--EDLKDMERR----QQQKLKMQAEIKRINDENQKQKAELLAQEKLA 336
+ +M + M + + + ++E+ +QQ +M+ +++ + DE Q + L E
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 337 DQMVMEFT-------------KKKMAREA-EFEAEQERIRREKEKEIARLRAMQEKAQDY 382
M +F KK++ R+ E EAE E R+++ +A + ++ +D
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622
Query: 383 QAEQDALRAKRNQ-----------------EVADREWRRKE-----KENARKKMETEAEL 420
+A D+ R++ E+ D R+E KEN +K EAE+
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682
Query: 421 RKSRLEQVAFKEHALAVQVQRDRDEF-----------------ERILRAQREQIEKERLE 463
+ + E++A E A Q Q++RDE +R L A+ Q+E+E LE
Sbjct: 1683 IQLQ-EELAAAERAKR-QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE-LE 1739
Query: 464 EEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLK-EEAQKRRERIDEIKRKKL 522
EE+ G + N+ R + N Q + N E K E A+++ ER ++ + KL
Sbjct: 1740 EEQ---GNTELIND--RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794
Query: 523 EELRAT 528
+E+ T
Sbjct: 1795 QEMEGT 1800
Score = 77.4 bits (189), Expect = 3e-14
Identities = 103/465 (22%), Positives = 212/465 (45%), Gaps = 78/465 (16%)
Query: 128 DQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLS---DLEEVAKERAQNLLQRANKLR 184
DQ +EK T+ A ++ + E K LS LEE +++A+ L+R NK
Sbjct: 1447 DQLLAEEK--TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE--LERLNKQF 1502
Query: 185 MEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQK------ELD-----TEEKRLD---- 229
+ E+L SK + H + ++ +QQ+++ EL+ TE+ +L
Sbjct: 1503 RTEMEDLMS-SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 230 -QMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLE 288
Q M+ + ++ +Q ++E +++++ +R R++ ++E +++RS+ R++ E L+
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK-LEMDLK 1620
Query: 289 YMEQLQEEDLKDMERRQQQKLKMQAEIK---RINDENQKQKAELLAQEK--------LAD 337
+E + K+ + +Q K+QA++K R D+ + + E+LAQ K +
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680
Query: 338 QMVMEFTKKKMAREAEFEAEQERIR----------------REKEKEIARLRAMQEKAQD 381
+M+ + A A+ +A+QER EK + AR+ ++E+ ++
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740
Query: 382 YQAEQDAL--RAKR--------NQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFK 431
Q + + R K+ N ++ ++ ENAR+++E + + K +L+++
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM--- 1797
Query: 432 EHALAVQVQRDRDEFERILRAQREQIEKERLEE----------EKKATGRLQHANELRRQ 481
E + + + E + EQ++ E E EKK L ++ RR
Sbjct: 1798 EGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857
Query: 482 VRENQQKEVQNRIAT-FEEGRRLKEEAQKRRERIDEIKRKKLEEL 525
Q K+ ++ +T ++ +R EEA++ +R + +RK EL
Sbjct: 1858 AE--QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Score = 77.0 bits (188), Expect = 4e-14
Identities = 97/442 (21%), Positives = 196/442 (44%), Gaps = 64/442 (14%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EELEA K E E T+D+ ++++ ++E N KK LEE AK + +
Sbjct: 1139 EELEA----LKTELEDTLDSTAAQQELRSKREQEVNILKKT--LEEEAKTHEAQIQEMRQ 1192
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM---EVERQK 238
K + EEL + + K + + Q LE ++ EL E K L Q E +R+K
Sbjct: 1193 K-HSQAVEELAEQLEQTKRVKANLEKAKQTLENER--GELANEVKVLLQGKGDSEHKRKK 1249
Query: 239 SIQRQEELERKRREERIRGRRQIVEQMEKNQEERSL---LAEQREQEKEQMLEYMEQLQE 295
+ +EL+ K E R R ++ +++ K Q E L Q + + ++ + L E
Sbjct: 1250 VEAQLQELQVKFNEGE-RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-E 1307
Query: 296 EDLKD----MERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMARE 351
L+D ++ +QKL + ++K++ DE + +L +E+ + +
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI-------- 1359
Query: 352 AEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAR 411
A A+ ++++ E + L +E + Q + + L + ++VA + K K +
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419
Query: 412 KKME-------------TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIE 458
++++ E ++ + +Q+ +E ++ + +RD RA+ E E
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD------RAEAEARE 1473
Query: 459 KE--------RLEEEKKATGRLQHANELRRQVRE---NQQKEVQNRIATFEEGRR-LKEE 506
KE LEE + L+ N+ R E + + +V + E+ +R L+++
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 507 AQKRRERIDEIKRKKLEELRAT 528
++ + +++E++ +EL+AT
Sbjct: 1534 VEEMKTQLEELE----DELQAT 1551
Score = 71.2 bits (173), Expect = 2e-12
Identities = 94/440 (21%), Positives = 201/440 (45%), Gaps = 42/440 (9%)
Query: 89 ELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKI 148
E ++ ++D G+S+ E E+ K A EE++ + + + E +AT DA + +
Sbjct: 1507 EDLMSSKDDVGKSV----HELEKSKRALEQQV-EEMKTQLEELEDELQATEDAKLRLE-- 1559
Query: 149 MKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRD 208
+ + M + L +E ++E+ + L+++ ++ E E+E K S + A R
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV------AARK 1613
Query: 209 AQILEKQQIQKELDTEEKRLDQMMEVERQ-----KSIQRQEELERKRREERIRGRRQIVE 263
++ + ++ +D+ K D+ ++ R+ K R+ + R REE + ++ +
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673
Query: 264 QMEKNQEERSLLAEQ---REQEKEQMLEYMEQLQEEDLKDMERRQ---QQKLKMQAEIKR 317
+++ + E L E+ E+ K Q + ++L +E + ++K +++A I +
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733
Query: 318 INDENQKQKAEL-LAQEKLA------DQMVMEFTKKKMAREAEFEAEQERIRREKEKEIA 370
+ +E ++++ L ++L DQ+ + ++ + A Q+ R+ KE ++
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV- 1792
Query: 371 RLRAMQEKAQD-YQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVA 429
+L+ M+ + Y+A AL AK Q + KE++ A K++ + K L QV
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 430 FKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKE 489
E A Q + D+ L+ + Q+E E E++A Q AN RR+++ +
Sbjct: 1853 -DERRNAEQYKDQADKASTRLKQLKRQLE----EAEEEA----QRANASRRKLQRELEDA 1903
Query: 490 VQNRIATFEEGRRLKEEAQK 509
+ A E LK + ++
Sbjct: 1904 TETADAMNREVSSLKNKLRR 1923
Score = 67.0 bits (162), Expect = 4e-11
Identities = 77/360 (21%), Positives = 161/360 (44%), Gaps = 43/360 (11%)
Query: 211 ILEKQQIQKELDTEEKRLDQMMEVE--RQKSIQRQEELERKRREERIRGRRQIVEQMEKN 268
+L+ + ++E+ +E+ L ++ E + + + E L+ + E+++ + Q+ + E
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 269 QEERSLLAE--QREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQK 326
E L A ++QE E++ +E EE+ E R Q +QAE K++ Q+ +
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEE----EERCQH---LQAEKKKMQQNIQELE 949
Query: 327 AEL----LAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEI---------ARLR 373
+L A++KL + V K K E + E + + KEK++ L
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 374 AMQEKAQD---YQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAF 430
+EK++ + + +A+ + + E +R+E E R+K+E ++ ++ ++
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 431 KEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEV 490
+ L +Q+ + +E + L E+ ++ + L+ EL Q+ E Q+
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNM--------ALKKIRELESQISELQED-- 1119
Query: 491 QNRIATFEEGRRLKEEAQKR--RERIDEIKRKKLEELRATGLPEKYCIEAERKANILPAT 548
E R K E QKR E ++ +K + + L +T ++ + E++ NIL T
Sbjct: 1120 ----LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 93.2 bits (230), Expect = 6e-19
Identities = 85/417 (20%), Positives = 191/417 (45%), Gaps = 31/417 (7%)
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQ 178
L ++ + + ++E+E D + +K+ ++ D E ERA+ +
Sbjct: 228 LKNGQISSEEPKQEEEREQGSDEISHHEKMEEE------------DKERAEAERARLEAE 275
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+++ EQ++++ D I + A ++ + E ++ ++ + E++ ++ ++ ++
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE 335
Query: 239 SIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDL 298
+E K E+R RQ +++ EK E A E+EK ++ E Q E+
Sbjct: 336 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEK 395
Query: 299 KDMERRQQQKLKMQAEIKRINDE--NQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEA 356
K Q+ K+K + ++I + N+K+ E Q + + E K A+ + +
Sbjct: 396 K--HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE 453
Query: 357 EQERIRRE--KEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENA---- 410
++ ++E K+++I + + +E+ + + + ++Q + K EN
Sbjct: 454 DKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP 513
Query: 411 --RKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQ-IEKERLEEEKK 467
R ++T+ ++E E + + + +EFE++ + Q+E +E E L+++++
Sbjct: 514 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 573
Query: 468 ATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
++ E RR+ Q+E ++ EE RRLKEE ++RR E KR+K+ E
Sbjct: 574 ERRKVLEEEEQRRK-----QEEADRKLREEEEKRRLKEEIERRRAEAAE-KRQKMPE 624
Score = 87.0 bits (214), Expect = 4e-17
Identities = 93/404 (23%), Positives = 180/404 (44%), Gaps = 37/404 (9%)
Query: 139 MDAVMTRKKIMKQKE---------MVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEE 189
MD R+++ +QK + + N D EE A+ER + R +LR +QEE
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRA--RQERLRQKQEE 56
Query: 190 ELKDM--SKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELE 247
E ++ +NA+ + Q E D E L+++ E ++ + QE LE
Sbjct: 57 ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
Query: 248 RKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQ 307
R++ + + + Q + AE EKE+ E ++ E + + + Q
Sbjct: 117 RQKEFDPTITDASLSLPSRRMQNDT---AENETTEKEEKSESRQERYEIEETETVTKSYQ 173
Query: 308 KLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRRE-KE 366
K + + ++ +K++ E +EK + E + M E E+++E + K
Sbjct: 174 KNDWRDAEENKKEDKEKEEEE---EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKN 230
Query: 367 KEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLE 426
+I+ +E Q+ + EQ + ++++ + + R E E AR + E ++ + +
Sbjct: 231 GQISS----EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
Query: 427 QVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL-EEEKKATGRLQHANELRRQVREN 485
++A + + + + E ER RE E+ER+ EEEK+A Q E ++ E
Sbjct: 287 KIADERARIEAEEKAAAQERER-----REAEERERMREEEKRAAEERQRIKEEEKRAAEE 341
Query: 486 QQKEVQNRIATFEEGRRLKEE-----AQKRRERIDEIKRKKLEE 524
+Q+ + EE +R+KEE +++R R +E ++ K+EE
Sbjct: 342 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Score = 84.3 bits (207), Expect = 3e-16
Identities = 103/463 (22%), Positives = 205/463 (44%), Gaps = 61/463 (13%)
Query: 121 REELEARDQAFKKEKEATMDA----VMTRKKIMKQKE----MVWNNNKKLSDLEEVAKER 172
+E+ E ++ +K K ++ VM +K + +E M N + S+ + +ER
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 173 AQNLLQRANKLRMEQEE-ELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQM 231
Q + ++ +ME+E+ E + + L A+ E+++I+ E D +
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAE----------ERERIKAEQDKKIADERAR 294
Query: 232 MEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQ---MLE 288
+E E + + Q +E E + RE ++ E+ ++ +EE AE+R++ KE+ E
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Query: 289 YMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQ---KAELLAQEKLADQMVMEFTK 345
++++EE+ + E RQ+ + + + + K + KQ K + + K+ + V + +
Sbjct: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
Query: 346 KKMAREAEFEAEQER---IRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREW 402
K E + + ++ + ++++ E++ +++A +EK Q+ + K + D+E
Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Query: 403 RRKEKENA-RKKMETEAELRKSRL------------------EQVAFKEHALAVQVQRDR 443
+ + K RKK TE + + V KE A QV+ +
Sbjct: 475 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 534
Query: 444 DEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRL 503
E LR +R + E E E+ K Q E ++ E ++K + R EE +R
Sbjct: 535 RLEE--LRRRRGETESEEFEKLK------QKQQEAALELEELKKKREERRKVLEEEEQRR 586
Query: 504 KEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILP 546
K+E R+ R +E KR+ EE+ E+ EA K +P
Sbjct: 587 KQEEADRKLREEEEKRRLKEEI------ERRRAEAAEKRQKMP 623
Score = 74.3 bits (181), Expect = 3e-13
Identities = 80/448 (17%), Positives = 194/448 (43%), Gaps = 63/448 (14%)
Query: 92 VPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQ 151
VP E+ + E + + + REE + E++ D +T +
Sbjct: 74 VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP 133
Query: 152 KEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQI 211
+ N+ + E+ K ++ ++ E+++ + + + + RDA+
Sbjct: 134 SRRMQNDTAENETTEKEEKSESR-----------QERYEIEETETVTKSYQKNDWRDAEE 182
Query: 212 LEKQQIQKELDTEEKRL------DQMMEVERQKSIQRQEEL-------------ERKRRE 252
+K+ +KE + EEK +Q+ + +K+ + QEE E K+ E
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 253 ERIRGRRQIV--EQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLK 310
ER +G +I E+ME+ +ER+ R + +E+ E ++ Q++ + D ++ +
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEER--ERIKAEQDKKIAD------ERAR 294
Query: 311 MQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIA 370
++AE K E ++++AE + + ++ E ++ E E++RI+ E+++
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Query: 371 RLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAF 430
+ ++E+ + E+ RA+ ++ E +R ++ +K E +++ ++EQ
Sbjct: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ--- 411
Query: 431 KEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEV 490
+ + + + +++ +E+K T L+ E + + +++++
Sbjct: 412 --------------------KIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451
Query: 491 QNRIATFEEGRRLKEEAQKRRERIDEIK 518
Q TF++ E+ +K +E +E+K
Sbjct: 452 QEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Score = 52.8 bits (125), Expect = 8e-07
Identities = 49/251 (19%), Positives = 114/251 (45%), Gaps = 33/251 (13%)
Query: 107 EEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLE 166
EE +R + + E + R++ +++K A + + +K+ ++ E W N KK + +
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDK 427
Query: 167 EVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEK 226
+ ++ K++ ++E+ +D K I+D +I + ++ ++E+ +
Sbjct: 428 LQTAVLKKQGEEKGTKVQAKREKLQEDKPTF----KKEEIKDEKIKKDKEPKEEVKSFMD 483
Query: 227 RLDQMMEVERQ---------------------------KSIQRQEELERKRREERIRGRR 259
R EV+ Q K + ++E +R E +R RR
Sbjct: 484 RKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRR 543
Query: 260 QIVE--QMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKR 317
E + EK ++++ A + E+ K++ E + L+EE+ + + +KL+ + E +R
Sbjct: 544 GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 603
Query: 318 INDENQKQKAE 328
+ +E ++++AE
Sbjct: 604 LKEEIERRRAE 614
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/212 (18%), Positives = 94/212 (44%), Gaps = 16/212 (7%)
Query: 120 TREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQR 179
T ++ E +D+ KK+KE + K M +K+ + + + +N R
Sbjct: 457 TFKKEEIKDEKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 512
Query: 180 ANKLRMEQEEELKDMSKIILNAKCHAIRDAQ-ILEKQQIQKELDTEEKRLDQMMEVERQK 238
+E + ++ + +R + E ++ +K ++K+ + +E+E K
Sbjct: 513 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK---LKQKQQEAALELEELK 569
Query: 239 SIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDL 298
+++EE + EE R +++ ++ + +EE+ L E+ E+ + + E +++ E+ L
Sbjct: 570 --KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 627
Query: 299 KDMER------RQQQKLKMQAEIKRINDENQK 324
D ++ + LK++ + +N QK
Sbjct: 628 SDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 659
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 92.8 bits (229), Expect = 7e-19
Identities = 74/304 (24%), Positives = 156/304 (51%), Gaps = 26/304 (8%)
Query: 202 KCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQI 261
K A + Q + +++ + + EE++ + + ++++ ++RQ+E ERKRREE RR+
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 784
Query: 262 VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDME--RRQQQKLKMQAEIKRIN 319
E + + +E+ L QRE+E+ Q QEE L+ +E RR++++ + Q E+ R
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQ-------QEEALRRLEERRREEEERRKQEELLR-- 835
Query: 320 DENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLR-AMQEK 378
Q+++A A+E+ Q +E + +M EA +E R+ KE E+ R + M+++
Sbjct: 836 --KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 893
Query: 379 AQDYQAEQDALRAKRNQEVADRE------WRRKEKENARKKMETEAELRKSRLEQVAFKE 432
Q +A + + ++ Q++A + W ++ A + T + +LE+ +E
Sbjct: 894 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE--RE 951
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLE---EEKKATGRLQHANELRRQVRENQQKE 489
L + +R + E + L+ Q++Q ++++L K +G + E++++ QK+
Sbjct: 952 RQLREEQRRQQRELMKALQQQQQQ-QQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQ 1010
Query: 490 VQNR 493
Q +
Sbjct: 1011 QQQQ 1014
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/303 (26%), Positives = 150/303 (49%), Gaps = 47/303 (15%)
Query: 228 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287
L+Q+ ++E+ K+ + LE++RRE +R +R+ E+ K QEE L +Q E + Q
Sbjct: 717 LEQLQQLEKAKAAK----LEQERREAEMRAKRE--EEERKRQEE--LRRQQEEILRRQQE 768
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKK 347
E ++ +EE+L R+Q++ L+ Q E + I Q+++ E QE+ ++ ++
Sbjct: 769 EERKRREEEELA--RRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRL------EE 819
Query: 348 MAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEK 407
RE E +QE + R++E+E A+ +E+AQ + E++ LR E+
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQR-RLEENRLRM--------------EE 864
Query: 408 ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
E AR + E E E ++ LE KE + R R + + LR ++Q ++++L + K
Sbjct: 865 EAARLRHE-EEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQLAQMKL 917
Query: 468 ATGRL--QHANELRRQ------VRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
+ Q +N Q + E Q+ E + EE RR + E K ++ + ++
Sbjct: 918 PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 977
Query: 520 KKL 522
+KL
Sbjct: 978 QKL 980
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/245 (24%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Query: 290 MEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMA 349
+EQLQ+ + + +Q++ + + KR +E ++Q+ QE++ + E K++
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 350 REAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKEN 409
E ++E +RR++E+EIA R Q + ++ Q +++ALR + + + E RRK++E
Sbjct: 777 EELARRKQEEALRRQREQEIALRR--QREEEERQQQEEALR-RLEERRREEEERRKQEEL 833
Query: 410 ARKKMETEAE-LRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKA 468
RK+ E A+ R+ Q +E+ L ++ + R E R +R+++E +R +E +
Sbjct: 834 LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQ 892
Query: 469 TGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRAT 528
+ Q A +Q ++ QQ ++ G++ A + + + + +KLEE R
Sbjct: 893 RQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 952
Query: 529 GLPEK 533
L E+
Sbjct: 953 QLREE 957
Score = 66.6 bits (161), Expect = 6e-11
Identities = 66/307 (21%), Positives = 137/307 (44%), Gaps = 26/307 (8%)
Query: 129 QAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE 188
Q +K K A ++ ++ ++E K+ +L +E + + K R E+E
Sbjct: 721 QQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREEEE 778
Query: 189 EELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQR-QEELE 247
+ + + + I L +Q+ ++E +E+ L ++ E R++ +R QEEL
Sbjct: 779 LARRKQEEALRRQREQEI----ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 834
Query: 248 RKRREERIR-------GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEY--------MEQ 292
RK+ EE + +R++ E + +EE + L + E+ K + LE Q
Sbjct: 835 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ 894
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
Q+E L+ ++++QQQ + A++K + Q++ A + A + E K + RE
Sbjct: 895 QQQEALRRLQQQQQQ--QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 952
Query: 353 EFEAEQERIRREKEKEIARLRAMQEKAQD--YQAEQDALRAKRNQEVADREWRRKEKENA 410
+ EQ R +RE K + + + Q++ + + K E+ E R+ +K+
Sbjct: 953 QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1012
Query: 411 RKKMETE 417
+++ +
Sbjct: 1013 QQQQHQQ 1019
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 58/297 (19%)
Query: 277 EQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE--- 333
+Q ++Q L + Q+Q + +QQ + + K Q+Q+ LL Q+
Sbjct: 600 DQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT 659
Query: 334 ---KLADQMVMEFTKKKMA-------REAEFEAEQERI------------------RREK 365
+++DQ ++ + ++ E + A Q + E+
Sbjct: 660 LKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQ 719
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR--EWRRKEKENARKKMETEAELRKS 423
+++ + +A + + + +AE +RAKR +E R E RR+++E R++ E E + R+
Sbjct: 720 LQQLEKAKAAKLEQERREAE---MRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 424 RLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKE-------RLEEEKKATGRLQHAN 476
E++A ++ A++ QR++ E LR QRE+ E++ RLEE ++ +
Sbjct: 777 --EELARRKQEEALRRQREQ---EIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 831
Query: 477 ELRRQVRE------NQQKEVQNRIATFEEGR-RLKEEAQKRRERIDEIKRKKLEELR 526
EL R+ E +++E Q R+ EE R R++EEA + R +E KRK+LE R
Sbjct: 832 ELLRKQEEEAAKWAREEEEAQRRL---EENRLRMEEEAARLRHEEEERKRKELEVQR 885
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 35/163 (21%)
Query: 380 QDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ Q + A AK QE + E R K +E RK+ E ELR+ +
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE---ELRRQQ--------------- 759
Query: 440 QRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEE 499
E ILR Q+E+ E++R EEE+ A + + A LRRQ +++E+ R EE
Sbjct: 760 -------EEILRRQQEE-ERKRREEEELARRKQEEA--LRRQ----REQEIALRRQREEE 805
Query: 500 GRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
R+ +EEA +R ++E +R++ E + L K EA + A
Sbjct: 806 ERQQQEEALRR---LEERRREEEERRKQEELLRKQEEEAAKWA 845
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 92.8 bits (229), Expect = 7e-19
Identities = 74/304 (24%), Positives = 156/304 (51%), Gaps = 26/304 (8%)
Query: 202 KCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQI 261
K A + Q + +++ + + EE++ + + ++++ ++RQ+E ERKRREE RR+
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 811
Query: 262 VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDME--RRQQQKLKMQAEIKRIN 319
E + + +E+ L QRE+E+ Q QEE L+ +E RR++++ + Q E+ R
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQ-------QEEALRRLEERRREEEERRKQEELLR-- 862
Query: 320 DENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLR-AMQEK 378
Q+++A A+E+ Q +E + +M EA +E R+ KE E+ R + M+++
Sbjct: 863 --KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 920
Query: 379 AQDYQAEQDALRAKRNQEVADRE------WRRKEKENARKKMETEAELRKSRLEQVAFKE 432
Q +A + + ++ Q++A + W ++ A + T + +LE+ +E
Sbjct: 921 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE--RE 978
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLE---EEKKATGRLQHANELRRQVRENQQKE 489
L + +R + E + L+ Q++Q ++++L K +G + E++++ QK+
Sbjct: 979 RQLREEQRRQQRELMKALQQQQQQ-QQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQ 1037
Query: 490 VQNR 493
Q +
Sbjct: 1038 QQQQ 1041
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/303 (26%), Positives = 150/303 (49%), Gaps = 47/303 (15%)
Query: 228 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287
L+Q+ ++E+ K+ + LE++RRE +R +R+ E+ K QEE L +Q E + Q
Sbjct: 744 LEQLQQLEKAKAAK----LEQERREAEMRAKRE--EEERKRQEE--LRRQQEEILRRQQE 795
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKK 347
E ++ +EE+L R+Q++ L+ Q E + I Q+++ E QE+ ++ ++
Sbjct: 796 EERKRREEEELA--RRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRL------EE 846
Query: 348 MAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEK 407
RE E +QE + R++E+E A+ +E+AQ + E++ LR E+
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQR-RLEENRLRM--------------EE 891
Query: 408 ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
E AR + E E E ++ LE KE + R R + + LR ++Q ++++L + K
Sbjct: 892 EAARLRHE-EEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQLAQMKL 944
Query: 468 ATGRL--QHANELRRQ------VRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
+ Q +N Q + E Q+ E + EE RR + E K ++ + ++
Sbjct: 945 PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 1004
Query: 520 KKL 522
+KL
Sbjct: 1005 QKL 1007
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/245 (24%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Query: 290 MEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMA 349
+EQLQ+ + + +Q++ + + KR +E ++Q+ QE++ + E K++
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 350 REAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKEN 409
E ++E +RR++E+EIA R Q + ++ Q +++ALR + + + E RRK++E
Sbjct: 804 EELARRKQEEALRRQREQEIALRR--QREEEERQQQEEALR-RLEERRREEEERRKQEEL 860
Query: 410 ARKKMETEAE-LRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKA 468
RK+ E A+ R+ Q +E+ L ++ + R E R +R+++E +R +E +
Sbjct: 861 LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQ 919
Query: 469 TGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRAT 528
+ Q A +Q ++ QQ ++ G++ A + + + + +KLEE R
Sbjct: 920 RQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 979
Query: 529 GLPEK 533
L E+
Sbjct: 980 QLREE 984
Score = 66.6 bits (161), Expect = 6e-11
Identities = 66/307 (21%), Positives = 137/307 (44%), Gaps = 26/307 (8%)
Query: 129 QAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE 188
Q +K K A ++ ++ ++E K+ +L +E + + K R E+E
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREEEE 805
Query: 189 EELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQR-QEELE 247
+ + + + I L +Q+ ++E +E+ L ++ E R++ +R QEEL
Sbjct: 806 LARRKQEEALRRQREQEI----ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 861
Query: 248 RKRREERIR-------GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEY--------MEQ 292
RK+ EE + +R++ E + +EE + L + E+ K + LE Q
Sbjct: 862 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ 921
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
Q+E L+ ++++QQQ + A++K + Q++ A + A + E K + RE
Sbjct: 922 QQQEALRRLQQQQQQ--QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 979
Query: 353 EFEAEQERIRREKEKEIARLRAMQEKAQD--YQAEQDALRAKRNQEVADREWRRKEKENA 410
+ EQ R +RE K + + + Q++ + + K E+ E R+ +K+
Sbjct: 980 QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1039
Query: 411 RKKMETE 417
+++ +
Sbjct: 1040 QQQQHQQ 1046
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 58/297 (19%)
Query: 277 EQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE--- 333
+Q ++Q L + Q+Q + +QQ + + K Q+Q+ LL Q+
Sbjct: 627 DQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT 686
Query: 334 ---KLADQMVMEFTKKKMA-------REAEFEAEQERI------------------RREK 365
+++DQ ++ + ++ E + A Q + E+
Sbjct: 687 LKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQ 746
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR--EWRRKEKENARKKMETEAELRKS 423
+++ + +A + + + +AE +RAKR +E R E RR+++E R++ E E + R+
Sbjct: 747 LQQLEKAKAAKLEQERREAE---MRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 424 RLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKE-------RLEEEKKATGRLQHAN 476
E++A ++ A++ QR++ E LR QRE+ E++ RLEE ++ +
Sbjct: 804 --EELARRKQEEALRRQREQ---EIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 858
Query: 477 ELRRQVRE------NQQKEVQNRIATFEEGR-RLKEEAQKRRERIDEIKRKKLEELR 526
EL R+ E +++E Q R+ EE R R++EEA + R +E KRK+LE R
Sbjct: 859 ELLRKQEEEAAKWAREEEEAQRRL---EENRLRMEEEAARLRHEEEERKRKELEVQR 912
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 35/163 (21%)
Query: 380 QDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ Q + A AK QE + E R K +E RK+ E ELR+ +
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE---ELRRQQ--------------- 786
Query: 440 QRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEE 499
E ILR Q+E+ E++R EEE+ A + + A LRRQ +++E+ R EE
Sbjct: 787 -------EEILRRQQEE-ERKRREEEELARRKQEEA--LRRQ----REQEIALRRQREEE 832
Query: 500 GRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
R+ +EEA +R ++E +R++ E + L K EA + A
Sbjct: 833 ERQQQEEALRR---LEERRREEEERRKQEELLRKQEEEAAKWA 872
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 92.8 bits (229), Expect = 7e-19
Identities = 74/304 (24%), Positives = 156/304 (51%), Gaps = 26/304 (8%)
Query: 202 KCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQI 261
K A + Q + +++ + + EE++ + + ++++ ++RQ+E ERKRREE RR+
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 262 VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDME--RRQQQKLKMQAEIKRIN 319
E + + +E+ L QRE+E+ Q QEE L+ +E RR++++ + Q E+ R
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQ-------QEEALRRLEERRREEEERRKQEELLR-- 841
Query: 320 DENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLR-AMQEK 378
Q+++A A+E+ Q +E + +M EA +E R+ KE E+ R + M+++
Sbjct: 842 --KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 379 AQDYQAEQDALRAKRNQEVADRE------WRRKEKENARKKMETEAELRKSRLEQVAFKE 432
Q +A + + ++ Q++A + W ++ A + T + +LE+ +E
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE--RE 957
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLE---EEKKATGRLQHANELRRQVRENQQKE 489
L + +R + E + L+ Q++Q ++++L K +G + E++++ QK+
Sbjct: 958 RQLREEQRRQQRELMKALQQQQQQ-QQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQ 1016
Query: 490 VQNR 493
Q +
Sbjct: 1017 QQQQ 1020
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/303 (26%), Positives = 150/303 (49%), Gaps = 47/303 (15%)
Query: 228 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287
L+Q+ ++E+ K+ + LE++RRE +R +R+ E+ K QEE L +Q E + Q
Sbjct: 723 LEQLQQLEKAKAAK----LEQERREAEMRAKRE--EEERKRQEE--LRRQQEEILRRQQE 774
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKK 347
E ++ +EE+L R+Q++ L+ Q E + I Q+++ E QE+ ++ ++
Sbjct: 775 EERKRREEEELA--RRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRL------EE 825
Query: 348 MAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEK 407
RE E +QE + R++E+E A+ +E+AQ + E++ LR E+
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQR-RLEENRLRM--------------EE 870
Query: 408 ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
E AR + E E E ++ LE KE + R R + + LR ++Q ++++L + K
Sbjct: 871 EAARLRHE-EEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 468 ATGRL--QHANELRRQ------VRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
+ Q +N Q + E Q+ E + EE RR + E K ++ + ++
Sbjct: 924 PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 983
Query: 520 KKL 522
+KL
Sbjct: 984 QKL 986
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/245 (24%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Query: 290 MEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMA 349
+EQLQ+ + + +Q++ + + KR +E ++Q+ QE++ + E K++
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 350 REAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKEN 409
E ++E +RR++E+EIA R Q + ++ Q +++ALR + + + E RRK++E
Sbjct: 783 EELARRKQEEALRRQREQEIALRR--QREEEERQQQEEALR-RLEERRREEEERRKQEEL 839
Query: 410 ARKKMETEAE-LRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKA 468
RK+ E A+ R+ Q +E+ L ++ + R E R +R+++E +R +E +
Sbjct: 840 LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQ 898
Query: 469 TGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRAT 528
+ Q A +Q ++ QQ ++ G++ A + + + + +KLEE R
Sbjct: 899 RQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 958
Query: 529 GLPEK 533
L E+
Sbjct: 959 QLREE 963
Score = 66.6 bits (161), Expect = 6e-11
Identities = 66/307 (21%), Positives = 137/307 (44%), Gaps = 26/307 (8%)
Query: 129 QAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE 188
Q +K K A ++ ++ ++E K+ +L +E + + K R E+E
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREEEE 784
Query: 189 EELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQR-QEELE 247
+ + + + I L +Q+ ++E +E+ L ++ E R++ +R QEEL
Sbjct: 785 LARRKQEEALRRQREQEI----ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 248 RKRREERIR-------GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEY--------MEQ 292
RK+ EE + +R++ E + +EE + L + E+ K + LE Q
Sbjct: 841 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ 900
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
Q+E L+ ++++QQQ + A++K + Q++ A + A + E K + RE
Sbjct: 901 QQQEALRRLQQQQQQ--QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 958
Query: 353 EFEAEQERIRREKEKEIARLRAMQEKAQD--YQAEQDALRAKRNQEVADREWRRKEKENA 410
+ EQ R +RE K + + + Q++ + + K E+ E R+ +K+
Sbjct: 959 QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1018
Query: 411 RKKMETE 417
+++ +
Sbjct: 1019 QQQQHQQ 1025
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 58/297 (19%)
Query: 277 EQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE--- 333
+Q ++Q L + Q+Q + +QQ + + K Q+Q+ LL Q+
Sbjct: 606 DQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT 665
Query: 334 ---KLADQMVMEFTKKKMA-------REAEFEAEQERI------------------RREK 365
+++DQ ++ + ++ E + A Q + E+
Sbjct: 666 LKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQ 725
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR--EWRRKEKENARKKMETEAELRKS 423
+++ + +A + + + +AE +RAKR +E R E RR+++E R++ E E + R+
Sbjct: 726 LQQLEKAKAAKLEQERREAE---MRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 424 RLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKE-------RLEEEKKATGRLQHAN 476
E++A ++ A++ QR++ E LR QRE+ E++ RLEE ++ +
Sbjct: 783 --EELARRKQEEALRRQREQ---EIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 477 ELRRQVRE------NQQKEVQNRIATFEEGR-RLKEEAQKRRERIDEIKRKKLEELR 526
EL R+ E +++E Q R+ EE R R++EEA + R +E KRK+LE R
Sbjct: 838 ELLRKQEEEAAKWAREEEEAQRRL---EENRLRMEEEAARLRHEEEERKRKELEVQR 891
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 35/163 (21%)
Query: 380 QDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ Q + A AK QE + E R K +E RK+ E ELR+ +
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE---ELRRQQ--------------- 765
Query: 440 QRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEE 499
E ILR Q+E+ E++R EEE+ A + + A LRRQ +++E+ R EE
Sbjct: 766 -------EEILRRQQEE-ERKRREEEELARRKQEEA--LRRQ----REQEIALRRQREEE 811
Query: 500 GRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
R+ +EEA +R ++E +R++ E + L K EA + A
Sbjct: 812 ERQQQEEALRR---LEERRREEEERRKQEELLRKQEEEAAKWA 851
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 92.8 bits (229), Expect = 7e-19
Identities = 74/304 (24%), Positives = 156/304 (51%), Gaps = 26/304 (8%)
Query: 202 KCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQI 261
K A + Q + +++ + + EE++ + + ++++ ++RQ+E ERKRREE RR+
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 262 VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDME--RRQQQKLKMQAEIKRIN 319
E + + +E+ L QRE+E+ Q QEE L+ +E RR++++ + Q E+ R
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQ-------QEEALRRLEERRREEEERRKQEELLR-- 841
Query: 320 DENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLR-AMQEK 378
Q+++A A+E+ Q +E + +M EA +E R+ KE E+ R + M+++
Sbjct: 842 --KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 379 AQDYQAEQDALRAKRNQEVADRE------WRRKEKENARKKMETEAELRKSRLEQVAFKE 432
Q +A + + ++ Q++A + W ++ A + T + +LE+ +E
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE--RE 957
Query: 433 HALAVQVQRDRDEFERILRAQREQIEKERLE---EEKKATGRLQHANELRRQVRENQQKE 489
L + +R + E + L+ Q++Q ++++L K +G + E++++ QK+
Sbjct: 958 RQLREEQRRQQRELMKALQQQQQQ-QQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQ 1016
Query: 490 VQNR 493
Q +
Sbjct: 1017 QQQQ 1020
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/303 (26%), Positives = 150/303 (49%), Gaps = 47/303 (15%)
Query: 228 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287
L+Q+ ++E+ K+ + LE++RRE +R +R+ E+ K QEE L +Q E + Q
Sbjct: 723 LEQLQQLEKAKAAK----LEQERREAEMRAKRE--EEERKRQEE--LRRQQEEILRRQQE 774
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKK 347
E ++ +EE+L R+Q++ L+ Q E + I Q+++ E QE+ ++ ++
Sbjct: 775 EERKRREEEELA--RRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRL------EE 825
Query: 348 MAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEK 407
RE E +QE + R++E+E A+ +E+AQ + E++ LR E+
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQR-RLEENRLRM--------------EE 870
Query: 408 ENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
E AR + E E E ++ LE KE + R R + + LR ++Q ++++L + K
Sbjct: 871 EAARLRHE-EEERKRKELEVQRQKE------LMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 468 ATGRL--QHANELRRQ------VRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR 519
+ Q +N Q + E Q+ E + EE RR + E K ++ + ++
Sbjct: 924 PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 983
Query: 520 KKL 522
+KL
Sbjct: 984 QKL 986
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/245 (24%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Query: 290 MEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMA 349
+EQLQ+ + + +Q++ + + KR +E ++Q+ QE++ + E K++
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 350 REAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKEN 409
E ++E +RR++E+EIA R Q + ++ Q +++ALR + + + E RRK++E
Sbjct: 783 EELARRKQEEALRRQREQEIALRR--QREEEERQQQEEALR-RLEERRREEEERRKQEEL 839
Query: 410 ARKKMETEAE-LRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKA 468
RK+ E A+ R+ Q +E+ L ++ + R E R +R+++E +R +E +
Sbjct: 840 LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-KRKELEVQRQKELMRQ 898
Query: 469 TGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRAT 528
+ Q A +Q ++ QQ ++ G++ A + + + + +KLEE R
Sbjct: 899 RQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 958
Query: 529 GLPEK 533
L E+
Sbjct: 959 QLREE 963
Score = 66.6 bits (161), Expect = 6e-11
Identities = 66/307 (21%), Positives = 137/307 (44%), Gaps = 26/307 (8%)
Query: 129 QAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQE 188
Q +K K A ++ ++ ++E K+ +L +E + + K R E+E
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREEEE 784
Query: 189 EELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQR-QEELE 247
+ + + + I L +Q+ ++E +E+ L ++ E R++ +R QEEL
Sbjct: 785 LARRKQEEALRRQREQEI----ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 248 RKRREERIR-------GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEY--------MEQ 292
RK+ EE + +R++ E + +EE + L + E+ K + LE Q
Sbjct: 841 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ 900
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
Q+E L+ ++++QQQ + A++K + Q++ A + A + E K + RE
Sbjct: 901 QQQEALRRLQQQQQQ--QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER 958
Query: 353 EFEAEQERIRREKEKEIARLRAMQEKAQD--YQAEQDALRAKRNQEVADREWRRKEKENA 410
+ EQ R +RE K + + + Q++ + + K E+ E R+ +K+
Sbjct: 959 QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQ 1018
Query: 411 RKKMETE 417
+++ +
Sbjct: 1019 QQQQHQQ 1025
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 58/297 (19%)
Query: 277 EQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE--- 333
+Q ++Q L + Q+Q + +QQ + + K Q+Q+ LL Q+
Sbjct: 606 DQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT 665
Query: 334 ---KLADQMVMEFTKKKMA-------REAEFEAEQERI------------------RREK 365
+++DQ ++ + ++ E + A Q + E+
Sbjct: 666 LKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQ 725
Query: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR--EWRRKEKENARKKMETEAELRKS 423
+++ + +A + + + +AE +RAKR +E R E RR+++E R++ E E + R+
Sbjct: 726 LQQLEKAKAAKLEQERREAE---MRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 424 RLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKE-------RLEEEKKATGRLQHAN 476
E++A ++ A++ QR++ E LR QRE+ E++ RLEE ++ +
Sbjct: 783 --EELARRKQEEALRRQREQ---EIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 477 ELRRQVRE------NQQKEVQNRIATFEEGR-RLKEEAQKRRERIDEIKRKKLEELR 526
EL R+ E +++E Q R+ EE R R++EEA + R +E KRK+LE R
Sbjct: 838 ELLRKQEEEAAKWAREEEEAQRRL---EENRLRMEEEAARLRHEEEERKRKELEVQR 891
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 35/163 (21%)
Query: 380 QDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV 439
+ Q + A AK QE + E R K +E RK+ E ELR+ +
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE---ELRRQQ--------------- 765
Query: 440 QRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEE 499
E ILR Q+E+ E++R EEE+ A + + A LRRQ +++E+ R EE
Sbjct: 766 -------EEILRRQQEE-ERKRREEEELARRKQEEA--LRRQ----REQEIALRRQREEE 811
Query: 500 GRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKA 542
R+ +EEA +R ++E +R++ E + L K EA + A
Sbjct: 812 ERQQQEEALRR---LEERRREEEERRKQEELLRKQEEEAAKWA 851
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 91.7 bits (226), Expect = 2e-18
Identities = 79/374 (21%), Positives = 195/374 (52%), Gaps = 26/374 (6%)
Query: 147 KIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAI 206
++ +Q+ V ++ + E +E+ + ++ ++R EQE ++++ + + +
Sbjct: 81 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQ-V 138
Query: 207 RDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRR-QIVEQM 265
R+ + ++Q + + E + +Q +V Q+ R++E + + +E ++R + Q+ EQ
Sbjct: 139 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQE 198
Query: 266 EKNQEERSLLAEQREQ---EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDEN 322
+ E+ + EQ EQ ++EQM E EQ+++++ + M +++Q K + ++++ ++
Sbjct: 199 GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE-EQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 323 QKQKAELLAQEK-LADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQD 381
+KQ+ ++ QE+ + +Q +K+ + E EQE RE+E+++ + ++
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE 317
Query: 382 YQAEQDALRAKRNQEVADREWRRKEKE-NARKKMETEAELRKSRLEQVAFKEHALAVQVQ 440
EQ+ K+ +++ W +KE+ +++M + E + EQ+ +E + Q +
Sbjct: 318 QMREQEEQMGKQEEQM----WEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 441 RDRDEFERILRAQREQIEK--ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFE 498
+ R + E+ +R Q EQ+ K E++ E+K+ G E + Q+RE +++ + + E
Sbjct: 374 QMRKQEEQ-MRKQEEQMRKQEEQMGEQKEQMG------EQKEQMREQEEQMGEQK----E 422
Query: 499 EGRRLKEEAQKRRE 512
+ R+ +E +++E
Sbjct: 423 QMRKQEEHMGEQKE 436
Score = 88.2 bits (217), Expect = 2e-17
Identities = 81/384 (21%), Positives = 191/384 (49%), Gaps = 27/384 (7%)
Query: 147 KIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAI 206
++ +Q+ V ++ + E +E+ + ++ ++R EQE ++++ + + +
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQ-V 124
Query: 207 RDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRR-QIVEQM 265
R+ + ++Q + + E + +Q +V Q+ R++E + + +E ++R + Q+ EQ
Sbjct: 125 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 266 EKNQEERSLLAEQREQ---EKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDEN 322
+ +E+ + EQ Q ++EQM E EQ+Q+++ + M +++Q K + ++ ++
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE-EQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 323 QKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDY 382
QKQ+ ++ QE+ +M ++ E EQE RE+E+++ + + E+ +
Sbjct: 244 QKQEEQVQKQEE------------QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291
Query: 383 QAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRD 442
+++ +R + Q E R+++E R++ E + + EQ KE + Q
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ---KEQMWEQKEQMW 348
Query: 443 RDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRR 502
+ E + + Q EQ++K+ E+ +K +++ E R+ E +K+ + E+
Sbjct: 349 KQEEQ--MGEQEEQMQKQE-EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGE 405
Query: 503 LKEEAQKRRERIDEIKR--KKLEE 524
KE+ +++ E++ E K +K EE
Sbjct: 406 QKEQMREQEEQMGEQKEQMRKQEE 429
Score = 86.7 bits (213), Expect = 5e-17
Identities = 74/337 (21%), Positives = 175/337 (51%), Gaps = 15/337 (4%)
Query: 212 LEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRR-QIVEQMEKNQE 270
L ++++++L+T++ L Q +V Q+ R++E + + +E ++R + Q+ EQ + +E
Sbjct: 32 LHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 91
Query: 271 ERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQ--QKLKMQAEIKRINDENQKQKAE 328
+ + EQ Q +EQ + EQ + ++ + R+Q Q + + +++ + ++Q+ +
Sbjct: 92 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 151
Query: 329 LLAQE-KLADQMVMEFTKKKMAREAEFEA-EQERIRREKEKEIARLRAMQEKAQDYQAEQ 386
+ QE ++ +Q ++ RE E + EQE RE+E ++ + ++ EQ
Sbjct: 152 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211
Query: 387 DALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEF 446
+ K+ +++ ++E + +++E + E + + ++ EQV +E + Q ++ R++
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE---EQVQKQEEQMRKQEEQMREQE 268
Query: 447 ERILRAQREQI--EKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLK 504
E+ +R Q EQ+ +KE+ E+E++ + + E Q+RE +++ + E+ R +
Sbjct: 269 EQ-MREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE----EQMREQE 323
Query: 505 EEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
E+ K+ E++ E K + E+ E+ E E +
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ 360
Score = 81.6 bits (200), Expect = 2e-15
Identities = 76/412 (18%), Positives = 205/412 (49%), Gaps = 15/412 (3%)
Query: 119 LTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQ 178
+T EEL+ ++ ++E + + +K+ + +K E +E+ + +
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE 63
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+ ++R EQE ++++ + + +R+ + ++Q + + E + +Q +V Q+
Sbjct: 64 QEGQVR-EQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 239 SIQRQEELERKRREERIRGRR-QIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEED 297
R++E + + +E ++R + Q+ EQ + +E+ + EQ Q +EQ + EQ E
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ--EGQ 179
Query: 298 LKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAE 357
+++ E + +++ E + E ++Q E Q + ++ + E ++ +E + +
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239
Query: 358 QERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETE 417
+E++++++E+ + M+++ + + +++ +R + Q + +E +E++ E E
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG----EQE 295
Query: 418 AELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIE-KERLEEEK----KATGRL 472
++R+ EQ+ +E + Q ++ R++ E++ + + + E KE++ E+K K ++
Sbjct: 296 EQMREQE-EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Query: 473 QHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEE 524
E ++ E +K+ + E+ R+ +E+ +K+ E++ E K + E+
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ 406
Score = 78.2 bits (191), Expect = 2e-14
Identities = 59/262 (22%), Positives = 132/262 (50%), Gaps = 51/262 (19%)
Query: 125 EARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLR 184
E +Q K+E++ + +Q+E V +++ EE +++ + + ++ ++R
Sbjct: 224 EQEEQMRKQEEQ-----------MGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMR 272
Query: 185 MEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQE 244
++E+ LK +K+Q ++E T E+ +QM E E Q R++
Sbjct: 273 EQEEQMLK--------------------QKEQTEQEEQTGEQE-EQMREQEEQ---MREQ 308
Query: 245 ELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERR 304
E + + +EE++R + EQM K +E+ EQ ++KEQM + EQ+ E++ + M+++
Sbjct: 309 EEQMREQEEQMREQE---EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE-EQMQKQ 364
Query: 305 QQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRRE 364
++Q K + ++++ ++ +KQ+ ++ QE ++M + E EQ+ RE
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQE------------EQMGEQKEQMGEQKEQMRE 412
Query: 365 KEKEIARLRAMQEKAQDYQAEQ 386
+E+++ + K +++ EQ
Sbjct: 413 QEEQMGEQKEQMRKQEEHMGEQ 434
Score = 65.5 bits (158), Expect = 1e-10
Identities = 48/220 (21%), Positives = 110/220 (50%), Gaps = 16/220 (7%)
Query: 95 EDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEM 154
E+ GE ++ E+++ + ++E + R+Q +++ + ++ +K+ +Q+E
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ--EEQMREQEEQMLKQKEQTEQEEQ 290
Query: 155 VWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEK 214
+++ + EE +E+ + + ++ ++R EQEE++ + + K + + K
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMR-EQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349
Query: 215 QQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSL 274
Q+ Q E+ + + ++++ +++QEE RK+ EQM K +E+
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQE-----------EQMRKQEEQMGE 398
Query: 275 LAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE 314
EQ ++KEQM E EQ+ E+ K+ R+Q++ + Q E
Sbjct: 399 QKEQMGEQKEQMREQEEQMGEQ--KEQMRKQEEHMGEQKE 436
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/437 (20%), Positives = 205/437 (46%), Gaps = 45/437 (10%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE++A++ +K KE A K++ +QK K L L+E + + L A
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL--LQEQLQAETE-LYAEAE 907
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM-----EVER 236
++R+ + +++ +I+ H + +A++ E++ ++L E K++ Q M ++E
Sbjct: 908 EMRVRLAAKKQELEEIL-----HEM-EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 237 QKSIQRQEELERKRREERIRGRRQIV----EQMEKNQEERSLLAEQ---------REQEK 283
+++ +++ +LE+ E +I+ + +Q K +ER LL E+ E+EK
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 284 EQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEF 343
+ L ++ E + ++E R +++ K + E++++ + + ++ Q + E
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 344 TKKKMAREAEFEAEQERIRRE---KEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR 400
+ +E E +A R+ E K + ++R ++ D Q + D+ RA RN+ +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 401 EWRRKEKENARKKME-------TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQ 453
+E E + ++E T+ ELR R ++V + AL + + + + + +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 454 REQIEK--ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRR 511
+ +E+ E+LE+ K+A L + +Q E + ++ + + ++ E +K+
Sbjct: 1202 AQAVEELTEQLEQFKRAKANL----DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 512 E-RIDEIKRKKLEELRA 527
E ++ E++ K + RA
Sbjct: 1258 EAQVQELQSKCSDGERA 1274
Score = 84.0 bits (206), Expect = 3e-16
Identities = 93/439 (21%), Positives = 215/439 (48%), Gaps = 38/439 (8%)
Query: 121 REELEARDQAFKKEK--EATMDAVMTRKKIMKQKEMVWNNNKKL-SDLEEVAK-----ER 172
R E EAR++ K A +A+ ++++ + +M+ + L S ++V K E+
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 173 AQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
++ L+ + Q EEL+D + +AK + Q L K Q +++L +++ ++
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL-KGQFERDLQARDEQNEEKR 1591
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
+++ + + ELE +R++ + + +++E + ++ L A+ + +E+ ++ + +
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAK--KKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLA-----QEKLAD----QMVMEF 343
LQ + +KD +R + + EI EN+K+ L A QE LA + +
Sbjct: 1650 LQAQ-MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 344 TKKKMARE-AEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDAL--RAKR------- 393
K+++A E A + + ++ EK + AR+ ++E+ ++ Q +A+ R ++
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 394 -NQEVADREWRRKEKENARKKMETEAELRKSRLEQVA------FKEHALAVQVQRDRDEF 446
+ E+A ++ E+AR+++E + + +S+L ++ FK A++ + + E
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 447 ERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEE 506
+ A+ +Q + L+++ K + E R++ E +++ + A ++ +R EE
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 507 AQKRRERIDEIKRKKLEEL 525
A++ +RI+ +RK EL
Sbjct: 1889 AEEESQRINANRRKLQREL 1907
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/578 (22%), Positives = 254/578 (43%), Gaps = 81/578 (14%)
Query: 9 LSSSSAASNRSRNKAR---YRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQK 65
L S AA N++ + R +A+ +E++++L S A Q LR K +
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQE------LRAKREQEV 1176
Query: 66 TLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELE 125
T+ LD + + + ++M ++ E+ L E+F+R K A+ ++ LE
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQFKRAK-ANLDKNKQTLE 1230
Query: 126 ARDQAFKKEKEATMDAVM-TRKKIMKQKEMVWNNNKKLSDLEEVAKE------RAQNLLQ 178
+ E A K K + V K SD E E + QN ++
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+ E E + ++K + + ++D Q L +++ +++L+ K L Q+ E
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTK-LRQLEEERNSL 1348
Query: 239 SIQRQEELERKRREERIRGRR--QIVEQMEKNQEERSLLAEQREQEK--EQMLEYMEQLQ 294
Q EE+E K+ ER Q+ + +K Q+ S + E +K ++ +E + Q
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 295 EEDLKDMERRQQQKLKMQAEIKR--INDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
EE ++ ++ K ++Q E+ ++ +NQ+Q L +++ ++ K ++ A
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 353 EFEAEQERIRREKE-KEIARLRAMQEKAQ---DYQAEQDALRAKRNQEVADREWRRK--- 405
+ E REKE K ++ RA++E + + + L+A+ V+ ++ K
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 406 EKENARKKMETEAELRKSRLEQVAFKEHA-------LAVQVQRDRDEFERILRAQREQIE 458
E E +++ +ET+ E K++LE++ + A L V +Q + +FER L+A+ EQ E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 459 KER-------------LEEEKK-----ATGRLQHANELRR---------QVRENQQKEVQ 491
++R LE+E+K A + + +L+ + RE K+++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 492 NRIATFEEGRRLKEEAQKRRERI------DEIKRKKLE 523
A ++ +R E+A+ R+ I +E K K LE
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/438 (22%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EELEA K E E T+D+ T++++ ++E KK D EE AQ +Q
Sbjct: 1146 EELEA----LKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ--VQEMR 1198
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ------------QIQKELDTEEKRLD 229
+ + EEL + + AK + ++ Q LEK+ Q ++E++ ++K+L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 230 -QMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSL-LAEQREQEKEQML 287
Q+ E++ + S + E + +++ + V M E +++ LA+ Q+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV------- 340
+ E LQEE +QKL + +++++ +E + +L +E A Q +
Sbjct: 1319 DTQELLQEET--------RQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL 1369
Query: 341 ---MEFTKKKMAREAEFEAEQERIRREKEKEIARL-RAMQEKAQDYQAEQDALRAKRNQE 396
+ +KKK+ A E ++ +KEI L + +EKA Y D L +N+
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRL 1425
Query: 397 VADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV--QRDRDEFERILRAQR 454
+ + + +N R+ + + E ++ + +Q+ +E ++ + +RDR E E + +
Sbjct: 1426 QQELDDLVVDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 455 EQIEKERLEEEKKATGRLQHANELRRQVRE---NQQKEVQNRIATFEEGRR-LKEEAQKR 510
LEE +A L+ N++ + E + + +V + E+ +R L+ + ++
Sbjct: 1485 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 511 RERIDEIKRKKLEELRAT 528
+ +++E++ +EL+AT
Sbjct: 1545 KTQLEELE----DELQAT 1558
Score = 68.9 bits (167), Expect = 1e-11
Identities = 78/350 (22%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 211 ILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRR---EER--IRGRRQIVEQM 265
+L+ + ++E+ +E L + E +QK+ +ELE+K EE+ ++ + Q ++
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKE-RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 266 EKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQ 325
EE + ++QE E++L ME EE+ ++ Q ++ KM ++ + ++ +++
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAE 385
+A A++KL + V K K + + + + KE+++ R + E
Sbjct: 963 EA---ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 386 QDA-----LRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQ 440
+ A L+ K +++ E R K++E +R+ E E K +LE A H +Q
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQ----ELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 441 RDRDEFERILRAQREQIEK--ERLEEE-KKATGRLQHANELRRQVRENQQKEVQNRIATF 497
E + L + E+++ RL++E + L+ EL + + Q+ R A
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-- 1133
Query: 498 EEGRRLKEEAQKR--RERIDEIKRKKLEELRATGLPEKYCIEAERKANIL 545
R K E QKR E ++ +K + + L +T ++ + E++ +L
Sbjct: 1134 ----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/437 (20%), Positives = 205/437 (46%), Gaps = 45/437 (10%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EE++A++ +K KE A K++ +QK K L L+E + + L A
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL--LQEQLQAETE-LYAEAE 914
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM-----EVER 236
++R+ + +++ +I+ H + +A++ E++ ++L E K++ Q M ++E
Sbjct: 915 EMRVRLAAKKQELEEIL-----HEM-EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 237 QKSIQRQEELERKRREERIRGRRQIV----EQMEKNQEERSLLAEQ---------REQEK 283
+++ +++ +LE+ E +I+ + +Q K +ER LL E+ E+EK
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 284 EQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEF 343
+ L ++ E + ++E R +++ K + E++++ + + ++ Q + E
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 344 TKKKMAREAEFEAEQERIRRE---KEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADR 400
+ +E E +A R+ E K + ++R ++ D Q + D+ RA RN+ +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 401 EWRRKEKENARKKME-------TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQ 453
+E E + ++E T+ ELR R ++V + AL + + + + + +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 454 REQIEK--ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRR 511
+ +E+ E+LE+ K+A L + +Q E + ++ + + ++ E +K+
Sbjct: 1209 AQAVEELTEQLEQFKRAKANL----DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 512 E-RIDEIKRKKLEELRA 527
E ++ E++ K + RA
Sbjct: 1265 EAQVQELQSKCSDGERA 1281
Score = 84.0 bits (206), Expect = 3e-16
Identities = 93/439 (21%), Positives = 215/439 (48%), Gaps = 38/439 (8%)
Query: 121 REELEARDQAFKKEK--EATMDAVMTRKKIMKQKEMVWNNNKKL-SDLEEVAK-----ER 172
R E EAR++ K A +A+ ++++ + +M+ + L S ++V K E+
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 173 AQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM 232
++ L+ + Q EEL+D + +AK + Q L K Q +++L +++ ++
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL-KGQFERDLQARDEQNEEKR 1598
Query: 233 EVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQ 292
+++ + + ELE +R++ + + +++E + ++ L A+ + +E+ ++ + +
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAK--KKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 293 LQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLA-----QEKLAD----QMVMEF 343
LQ + +KD +R + + EI EN+K+ L A QE LA + +
Sbjct: 1657 LQAQ-MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 344 TKKKMARE-AEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDAL--RAKR------- 393
K+++A E A + + ++ EK + AR+ ++E+ ++ Q +A+ R ++
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 394 -NQEVADREWRRKEKENARKKMETEAELRKSRLEQVA------FKEHALAVQVQRDRDEF 446
+ E+A ++ E+AR+++E + + +S+L ++ FK A++ + + E
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 447 ERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEE 506
+ A+ +Q + L+++ K + E R++ E +++ + A ++ +R EE
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 507 AQKRRERIDEIKRKKLEEL 525
A++ +RI+ +RK EL
Sbjct: 1896 AEEESQRINANRRKLQREL 1914
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/578 (22%), Positives = 254/578 (43%), Gaps = 81/578 (14%)
Query: 9 LSSSSAASNRSRNKAR---YRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQK 65
L S AA N++ + R +A+ +E++++L S A Q LR K +
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQE------LRAKREQEV 1183
Query: 66 TLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELE 125
T+ LD + + + ++M ++ E+ L E+F+R K A+ ++ LE
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQFKRAK-ANLDKNKQTLE 1237
Query: 126 ARDQAFKKEKEATMDAVM-TRKKIMKQKEMVWNNNKKLSDLEEVAKE------RAQNLLQ 178
+ E A K K + V K SD E E + QN ++
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 179 RANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQK 238
+ E E + ++K + + ++D Q L +++ +++L+ K L Q+ E
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTK-LRQLEEERNSL 1355
Query: 239 SIQRQEELERKRREERIRGRR--QIVEQMEKNQEERSLLAEQREQEK--EQMLEYMEQLQ 294
Q EE+E K+ ER Q+ + +K Q+ S + E +K ++ +E + Q
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 295 EEDLKDMERRQQQKLKMQAEIKR--INDENQKQKAELLAQEKLADQMVMEFTKKKMAREA 352
EE ++ ++ K ++Q E+ ++ +NQ+Q L +++ ++ K ++ A
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 353 EFEAEQERIRREKE-KEIARLRAMQEKAQ---DYQAEQDALRAKRNQEVADREWRRK--- 405
+ E REKE K ++ RA++E + + + L+A+ V+ ++ K
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 406 EKENARKKMETEAELRKSRLEQVAFKEHA-------LAVQVQRDRDEFERILRAQREQIE 458
E E +++ +ET+ E K++LE++ + A L V +Q + +FER L+A+ EQ E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 459 KER-------------LEEEKK-----ATGRLQHANELRR---------QVRENQQKEVQ 491
++R LE+E+K A + + +L+ + RE K+++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 492 NRIATFEEGRRLKEEAQKRRERI------DEIKRKKLE 523
A ++ +R E+A+ R+ I +E K K LE
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/438 (22%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRAN 181
EELEA K E E T+D+ T++++ ++E KK D EE AQ +Q
Sbjct: 1153 EELEA----LKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ--VQEMR 1205
Query: 182 KLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQ------------QIQKELDTEEKRLD 229
+ + EEL + + AK + ++ Q LEK+ Q ++E++ ++K+L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 230 -QMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSL-LAEQREQEKEQML 287
Q+ E++ + S + E + +++ + V M E +++ LA+ Q+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV------- 340
+ E LQEE +QKL + +++++ +E + +L +E A Q +
Sbjct: 1326 DTQELLQEET--------RQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL 1376
Query: 341 ---MEFTKKKMAREAEFEAEQERIRREKEKEIARL-RAMQEKAQDYQAEQDALRAKRNQE 396
+ +KKK+ A E ++ +KEI L + +EKA Y D L +N+
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRL 1432
Query: 397 VADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQV--QRDRDEFERILRAQR 454
+ + + +N R+ + + E ++ + +Q+ +E ++ + +RDR E E + +
Sbjct: 1433 QQELDDLVVDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Query: 455 EQIEKERLEEEKKATGRLQHANELRRQVRE---NQQKEVQNRIATFEEGRR-LKEEAQKR 510
LEE +A L+ N++ + E + + +V + E+ +R L+ + ++
Sbjct: 1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 511 RERIDEIKRKKLEELRAT 528
+ +++E++ +EL+AT
Sbjct: 1552 KTQLEELE----DELQAT 1565
Score = 68.9 bits (167), Expect = 1e-11
Identities = 78/350 (22%), Positives = 161/350 (46%), Gaps = 29/350 (8%)
Query: 211 ILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRR---EER--IRGRRQIVEQM 265
+L+ + ++E+ +E L + E +QK+ +ELE+K EE+ ++ + Q ++
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKE-RQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 266 EKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQ 325
EE + ++QE E++L ME EE+ ++ Q ++ KM ++ + ++ +++
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 326 KAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAE 385
+A A++KL + V K K + + + + KE+++ R + E
Sbjct: 970 EA---ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 386 QDA-----LRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQ 440
+ A L+ K +++ E R K++E +R+ E E K +LE A H +Q
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQ----ELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 441 RDRDEFERILRAQREQIEK--ERLEEE-KKATGRLQHANELRRQVRENQQKEVQNRIATF 497
E + L + E+++ RL++E + L+ EL + + Q+ R A
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-- 1140
Query: 498 EEGRRLKEEAQKR--RERIDEIKRKKLEELRATGLPEKYCIEAERKANIL 545
R K E QKR E ++ +K + + L +T ++ + E++ +L
Sbjct: 1141 ----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,222,179
Number of Sequences: 37866
Number of extensions: 911674
Number of successful extensions: 39354
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 798
Number of HSP's successfully gapped in prelim test: 1464
Number of HSP's that attempted gapping in prelim test: 6945
Number of HSP's gapped (non-prelim): 10320
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.