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Search of human proteins with 78000171
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1482 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1457 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1387 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 1335 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1123 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 1023 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 778 0.0
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 409 e-114
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 408 e-114
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 408 e-113
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 407 e-113
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 384 e-106
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 382 e-106
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 291 1e-78
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 291 1e-78
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 278 1e-74
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 271 1e-72
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 106 9e-23
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 106 9e-23
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 106 9e-23
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 95 3e-19
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 92 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 84 6e-16
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 2e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 81 4e-15
gi|39930351 dynamin binding protein [Homo sapiens] 80 5e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 79 1e-14
gi|11321634 CD2-associated protein [Homo sapiens] 79 2e-14
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 79 2e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 79 2e-14
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1482 bits (3836), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI
Sbjct: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
Query: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT
Sbjct: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
Query: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK
Sbjct: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
Query: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS
Sbjct: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
Query: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY
Sbjct: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
Query: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP
Sbjct: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
Query: 421 RHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITN 480
RHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITN
Sbjct: 421 RHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITN 480
Query: 481 ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 540
ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE
Sbjct: 481 ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 540
Query: 541 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 600
HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI
Sbjct: 541 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 600
Query: 601 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 660
TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP
Sbjct: 601 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 660
Query: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
Query: 721 SRRTKQFGTFPGNYVKPLYL 740
SRRTKQFGTFPGNYVKPLYL
Sbjct: 721 SRRTKQFGTFPGNYVKPLYL 740
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1457 bits (3773), Expect = 0.0
Identities = 740/781 (94%), Positives = 740/781 (94%), Gaps = 41/781 (5%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 139
NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
Query: 140 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 199
TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
Sbjct: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
Query: 200 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 259
RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
Sbjct: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
Query: 260 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 319
TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
Sbjct: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
Query: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 379
AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
Sbjct: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
Query: 380 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 439
SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
Sbjct: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
Query: 440 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 499
HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
Sbjct: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
Query: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559
EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
Query: 560 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 619
EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
Sbjct: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
Query: 620 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 679
RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
Sbjct: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
Query: 680 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 739
DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
Sbjct: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
Query: 740 L 740
L
Sbjct: 781 L 781
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1387 bits (3590), Expect = 0.0
Identities = 737/905 (81%), Positives = 737/905 (81%), Gaps = 165/905 (18%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 100
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
Query: 101 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 145
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
Query: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
Query: 206 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 265
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
Query: 266 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 325
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI
Sbjct: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
Query: 326 YEYQPGKSSVLTNEKMS------------------------------------------- 342
YEYQPGKSSVLTNEKMS
Sbjct: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
Query: 343 -------SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
Query: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 455
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR
Sbjct: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
Query: 456 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 515
EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL
Sbjct: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
Query: 516 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 575
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
Query: 576 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 636 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 675
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 676 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 735
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 736 KPLYL 740
KPLYL
Sbjct: 901 KPLYL 905
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 1335 bits (3456), Expect = 0.0
Identities = 683/740 (92%), Positives = 683/740 (92%), Gaps = 56/740 (7%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI
Sbjct: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
Query: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT
Sbjct: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
Query: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK
Sbjct: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
Query: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS
Sbjct: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
Query: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY
Sbjct: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
Query: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP
Sbjct: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
Query: 421 RHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITN 480
RHFIPADYLESTEEFIR RRH
Sbjct: 421 RHFIPADYLESTEEFIR---------------------------RRH------------- 440
Query: 481 ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 540
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE
Sbjct: 441 ---------DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 484
Query: 541 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 600
HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI
Sbjct: 485 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 544
Query: 601 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 660
TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP
Sbjct: 545 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 604
Query: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 605 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 664
Query: 721 SRRTKQFGTFPGNYVKPLYL 740
SRRTKQFGTFPGNYVKPLYL
Sbjct: 665 SRRTKQFGTFPGNYVKPLYL 684
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1123 bits (2905), Expect = 0.0
Identities = 578/636 (90%), Positives = 578/636 (90%), Gaps = 56/636 (8%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 237 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 296
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 297 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 356
Query: 225 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 284
ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR
Sbjct: 357 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 416
Query: 285 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 344
SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA
Sbjct: 417 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 476
Query: 345 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 404
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 477 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 536
Query: 405 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 464
LKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 537 LKRPSSSASTKDSESPRHFIPADYLESTEEFIR--------------------------- 569
Query: 465 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 524
RRH DD EMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 570 RRH----------------------DD-------KEMRPARAKFDFKAQTLKELPLQKGD 600
Query: 525 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 584
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 601 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 660
Query: 585 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 644
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 661 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 720
Query: 645 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 704
DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD
Sbjct: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 780
Query: 705 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 740
IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 781 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 1023 bits (2646), Expect = 0.0
Identities = 551/698 (78%), Positives = 557/698 (79%), Gaps = 131/698 (18%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
Query: 225 ERSKDWYKTMFKQIHKLNRD---------------------------------------- 244
ERSKDWYKTMFKQIHKLNRD
Sbjct: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTP 448
Query: 245 ------DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 298
DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK
Sbjct: 449 SPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 508
Query: 299 SSSERNDWEPPDKKVDTRKYRAEP------------------------------------ 322
SSSERNDWEPPDKKVDTRKYRAEP
Sbjct: 509 SSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWY 568
Query: 323 -------------KSIYEYQPGKSSVL------TN----------------EKM------ 341
K I++Y PG S+L TN EKM
Sbjct: 569 KFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKA 628
Query: 342 -------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 394
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG
Sbjct: 629 PSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 688
Query: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 454
GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK
Sbjct: 689 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 748
Query: 455 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 514
REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT
Sbjct: 749 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
Query: 515 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 574
LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE
Sbjct: 809 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 868
Query: 575 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 634
YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR
Sbjct: 869 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928
Query: 635 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 672
PLVKNPVDYMDLPFSSSPSRSATASPQ + + +TP
Sbjct: 929 PLVKNPVDYMDLPFSSSPSRSATASPQF-SSHSKLITP 965
Score = 197 bits (500), Expect = 4e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 134 SSAYPSTTIVNPTI 147
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 170 bits (430), Expect = 5e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
Query: 721 SRRTKQFGTFPGNYVKPLYL 740
SRRTKQFGTFPGNYVKPLYL
Sbjct: 1273 SRRTKQFGTFPGNYVKPLYL 1292
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 733
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 734 YVKPL 738
Y++ L
Sbjct: 846 YIELL 850
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 494 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
Query: 552 YIELL 556
Y++ L
Sbjct: 1286 YVKPL 1290
Score = 32.0 bits (71), Expect = 2.1
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 561 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 617
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 618 TSRQGIFPITYV 629
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 778 bits (2010), Expect = 0.0
Identities = 411/502 (81%), Positives = 414/502 (82%), Gaps = 84/502 (16%)
Query: 244 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 303
DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER
Sbjct: 476 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 535
Query: 304 NDWEPPDKKVDTRKYRAEP----------------------------------------- 322
NDWEPPDKKVDTRKYRAEP
Sbjct: 536 NDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE 595
Query: 323 --------KSIYEYQPGKSSVL------TN----------------EKM----------- 341
K I++Y PG S+L TN EKM
Sbjct: 596 LEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANV 655
Query: 342 --SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 399
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL
Sbjct: 656 PQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 715
Query: 400 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 459
QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE
Sbjct: 716 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 775
Query: 460 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 519
ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP
Sbjct: 776 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 835
Query: 520 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 579
LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI
Sbjct: 836 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 895
Query: 580 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 639
AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN
Sbjct: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 955
Query: 640 PVDYMDLPFSSSPSRSATASPQ 661
PVDYMDLPFSSSPSRSATASPQ
Sbjct: 956 PVDYMDLPFSSSPSRSATASPQ 977
Score = 322 bits (825), Expect = 8e-88
Identities = 260/728 (35%), Positives = 351/728 (48%), Gaps = 148/728 (20%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
Query: 225 ERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEM 273
ERSKDWYKTMFKQIHKLNRD + + Y P Y F SE+TKS + PR +
Sbjct: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSG 448
Query: 274 SYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQ-- 329
+ I + ++ P + S ++ + +D P DT+ + P+S E
Sbjct: 449 TVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYI 508
Query: 330 --------------PGKSS---------------------------------------VL 336
P +SS VL
Sbjct: 509 DGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVL 568
Query: 337 TNEKMSSAISPTPEISSETPGYIYSSNFH----AVKRESDGAPGDL---------TSLEN 383
TNEKMS ISP P Y + S K+ D PGD T+L+
Sbjct: 569 TNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDK 628
Query: 384 ERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI----PADYLESTEEFIRRR 439
+ + ++ LE ++ L+ K PS++ + SP I P S ++R
Sbjct: 629 DLSLCQTELEADLEKMETLN--KAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRE 686
Query: 440 HD----DKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKR 495
D D L +++ K E DI + +G+ T + ++ +
Sbjct: 687 SDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD--------SESPRH 738
Query: 496 KSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP------ 549
++ + +F + KE L D + ++ ++ H G+ P
Sbjct: 739 FIPADYLESTEEFIRRRHDDKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFI 794
Query: 550 --RTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 607
+ +LL + A+ K + E A AKF+F T E+ +KG+ + + +Q+D
Sbjct: 795 TNERFGDLLNIDDTAKRKSGS-----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQID 849
Query: 608 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQ 667
+NWYEG G R GIFP TY++++ P +AQ
Sbjct: 850 QNWYEGEHHG--RVGIFPRTYIELL---------------------------PPAEKAQP 880
Query: 668 RRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQF 727
+++TP + + A +++ E+ R G+ + ++ + D+ W+ G T +
Sbjct: 881 KKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 937
Query: 728 GTFPGNYV 735
G FP YV
Sbjct: 938 GIFPITYV 945
Score = 197 bits (500), Expect = 4e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 134 SSAYPSTTIVNPTI 147
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 196 bits (498), Expect = 7e-50
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 557
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 558 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 600
P + + P + + E ++ + G +I
Sbjct: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
Query: 601 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 649
T R D N E PG FP + + +R
Sbjct: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
Query: 650 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 709
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
Query: 710 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 740
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 733
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 734 YVKPL 738
Y++ L
Sbjct: 868 YIELL 872
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 494 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 552 YIELL 556
Y++ L
Sbjct: 1145 YVKPL 1149
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 409 bits (1052), Expect = e-114
Identities = 285/765 (37%), Positives = 394/765 (51%), Gaps = 125/765 (16%)
Query: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
Query: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
Query: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
Query: 227 SKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SY 275
KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+
Sbjct: 180 PKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSH 239
Query: 276 IDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIY 326
D + A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+
Sbjct: 240 SDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIF 299
Query: 327 EYQPGKSSVLTNEK---------------------------MSSAISPTPEISSETPGYI 359
EY+PGKSS+L +E+ ++ + SP P + TP
Sbjct: 300 EYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP--- 356
Query: 360 YSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSAS 413
SS A+ K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 357 -SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSAS 406
Query: 414 TKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA----- 464
+F +RR + + L DQ + D+
Sbjct: 407 M-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTL 449
Query: 465 -RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQT 514
+ T P+ + L ++ +A R+ E PA+A +DFKAQT
Sbjct: 450 TKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQT 509
Query: 515 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVL 573
KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 510 SKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG 569
Query: 574 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 633
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K
Sbjct: 570 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 629
Query: 634 RPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQ 693
+ K DY D P S S S + Q+ T + Q + F QALY+Y P+
Sbjct: 630 KN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPR 686
Query: 694 NDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 687 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 408 bits (1049), Expect = e-114
Identities = 276/723 (38%), Positives = 380/723 (52%), Gaps = 112/723 (15%)
Query: 62 RQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSS 118
R +S WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 5 RDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSG 64
Query: 119 LIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA 178
+ + PS AY +N +IV+ Q S S + D
Sbjct: 65 GAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGT 116
Query: 179 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMF 235
+ P EKR V+K+ +DE GIP +R T +R KDWYKTMF
Sbjct: 117 TSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMF 171
Query: 236 KQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKR 284
KQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D +
Sbjct: 172 KQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK 231
Query: 285 SATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSV 335
A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 232 DASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI 291
Query: 336 LTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
L +E+ P P K+ D + + NE +Y+S ++
Sbjct: 292 LQHER------PPP------------------KKPLDYVQDHSSGVFNEASLYQSSID-- 325
Query: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQR 451
L+RP SSAS +F +RR + + L DQ
Sbjct: 326 -------RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQS 361
Query: 452 RLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS- 499
+ D+ + T P+ + L ++ +A R+
Sbjct: 362 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 421
Query: 500 ---EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 422 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
Query: 557 PPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 615
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+I
Sbjct: 482 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 541
Query: 616 PGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRS 675
PGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T +
Sbjct: 542 PGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 600
Query: 676 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 735
Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYV
Sbjct: 601 QGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
Query: 736 KPL 738
K L
Sbjct: 659 KRL 661
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 408 bits (1048), Expect = e-113
Identities = 279/703 (39%), Positives = 372/703 (52%), Gaps = 88/703 (12%)
Query: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
Query: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
Query: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
Query: 227 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGE 279
KDWYKTMFKQIH +++ LY+P YS T PLS S S ++ D
Sbjct: 180 PKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
Query: 280 KVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 338
V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 237 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 296
Query: 339 EKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGD 396
E+ +S + + S E P +S+F +R+S+ A G L ++ S G
Sbjct: 297 ERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGR 352
Query: 397 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 456
+ L G S S ++S+ S S R D+E
Sbjct: 353 VDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE------------ 381
Query: 457 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 516
+ R ++ + + ER G E PA+A +DFKAQT K
Sbjct: 382 ------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSK 424
Query: 517 ELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEY 575
EL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E
Sbjct: 425 ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 484
Query: 576 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
Query: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
K DY D P S S S + Q+ T + Q + F QALY+Y P+N+
Sbjct: 545 -TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNE 601
Query: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 602 DELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 407 bits (1045), Expect = e-113
Identities = 270/705 (38%), Positives = 374/705 (53%), Gaps = 89/705 (12%)
Query: 81 GNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPST 140
G S +AKG+RSV PNL +S S + +S + + PS AY
Sbjct: 4 GRDSQSPDSAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPS-AYSLP 62
Query: 141 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSR 200
+N +IV+ Q S S + D + P EKR
Sbjct: 63 ASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT---- 111
Query: 201 RVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSF 256
V+K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y++
Sbjct: 112 -VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTY 170
Query: 257 SEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL--------- 297
+ +P S P +K++ S+ D + A+ P+P
Sbjct: 171 NAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRD 230
Query: 298 KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPG 357
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P P
Sbjct: 231 RSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPW 290
Query: 358 YIYSSNFH----AVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSAS 413
Y + S K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 291 YKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSAS 341
Query: 414 TKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA----- 464
+F +RR + + L DQ + D+
Sbjct: 342 M-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTL 384
Query: 465 -RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQT 514
+ T P+ + L ++ +A R+ E PA+A +DFKAQT
Sbjct: 385 TKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQT 444
Query: 515 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVL 573
KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 445 SKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG 504
Query: 574 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 633
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K
Sbjct: 505 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 564
Query: 634 RPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQ 693
+ K DY D P S S S + Q+ T + Q + F QALY+Y P+
Sbjct: 565 KN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPR 621
Query: 694 NDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 622 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 384 bits (987), Expect = e-106
Identities = 231/542 (42%), Positives = 316/542 (58%), Gaps = 78/542 (14%)
Query: 220 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 273
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 274 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 319
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
Query: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 377
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
Query: 378 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR 437
L ++ S G + L G S S ++S+ S S
Sbjct: 185 PRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------------ 223
Query: 438 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS 497
R D+E + R ++ + + ER G
Sbjct: 224 -RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------P 253
Query: 498 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP 557
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 254 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 313
Query: 558 PAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 616
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IP
Sbjct: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
Query: 617 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 676
GT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 374 GTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
Query: 677 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK
Sbjct: 433 GGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Query: 737 PL 738
L
Sbjct: 491 RL 492
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 382 bits (981), Expect = e-106
Identities = 246/623 (39%), Positives = 344/623 (55%), Gaps = 111/623 (17%)
Query: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
Query: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK-------- 340
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
Query: 341 -------------------MSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 375
++ + SP P + TP SS A+ K+ D
Sbjct: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
Query: 376 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEF 435
+ + NE +Y+S ++ L+RP SSAS +F
Sbjct: 471 DHSSGVFNEASLYQSSID---------RSLERPMSSASM-----------------ASDF 504
Query: 436 IRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-- 483
+RR + + L DQ + D+ + T P+ +
Sbjct: 505 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 564
Query: 484 ---GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNW 536
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNW
Sbjct: 565 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 624
Query: 537 YEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFR 595
YEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S R
Sbjct: 625 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 684
Query: 596 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 655
KG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 685 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSD 743
Query: 656 ATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDG 715
S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDG
Sbjct: 744 RIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDG 801
Query: 716 WFVGTSRRTKQFGTFPGNYVKPL 738
WFVGTSRRTK FGTFPGNYVK L
Sbjct: 802 WFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 291 bits (746), Expect = 1e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
Query: 560 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 619 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 678
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
Query: 679 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 947 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 113 bits (283), Expect = 6e-25
Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)
Query: 220 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 272
PL+ +R KDWYKTMFKQIH +++ LY+P YS T PLS S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
Query: 273 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 331
++ D V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 63 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 332 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 389
KSS+L +E+ +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
Query: 390 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 419
S G + L G S S ++S+ S S
Sbjct: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
Score = 83.2 bits (204), Expect = 8e-16
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 549 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 608
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 609 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 668
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 838
Query: 669 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 728
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 839 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 891
Query: 729 TFPGNYVK 736
FP +YV+
Sbjct: 892 IFPVSYVE 899
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 666 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 725
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 759 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 811
Query: 726 QFGTFPGNYVKPL 738
+ G FP +YV+ L
Sbjct: 812 RVGIFPISYVEKL 824
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 291 bits (746), Expect = 1e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
Query: 560 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 619 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 678
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
Query: 679 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1043 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 121 bits (303), Expect = 3e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
Query: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 348
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
Query: 349 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 406
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
Query: 407 RPSSSASTKDSES 419
S ++S+ S S
Sbjct: 292 TKSFTSSSPSSPS 304
Score = 83.2 bits (204), Expect = 8e-16
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 549 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 608
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 609 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 668
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 934
Query: 669 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 728
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 935 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 987
Query: 729 TFPGNYVK 736
FP +YV+
Sbjct: 988 IFPVSYVE 995
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 666 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 725
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 855 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 907
Query: 726 QFGTFPGNYVKPL 738
+ G FP +YV+ L
Sbjct: 908 RVGIFPISYVEKL 920
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 278 bits (712), Expect = 1e-74
Identities = 203/606 (33%), Positives = 288/606 (47%), Gaps = 106/606 (17%)
Query: 196 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 250
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
Query: 251 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDW 306
PR+ ++ + P + S D + + RS P S++
Sbjct: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQ------- 221
Query: 307 EPPDKKVDTRKYRAEPKSIYE-YQPGKSSVLTNEKMSSAISPTP-EISSETPGYIYSSNF 364
P +V R+ + + E + + T ++ + P E S+ +
Sbjct: 222 --PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLEREL 279
Query: 365 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 424
+ E D DL ++E KS P Q + P+ AS S P
Sbjct: 280 AELSAELDK---DLRAIETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH--- 328
Query: 425 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 484
A YL S + D +R D +A G
Sbjct: 329 -APYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGG--------------- 372
Query: 485 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 544
+ R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR
Sbjct: 373 -------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGR 425
Query: 545 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 604
+GIFP Y+E+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R
Sbjct: 426 LGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIR 485
Query: 605 QVDENWYEGRIPGTSRQGIFPITYVDVIKRP----------------------------- 635
+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 486 KVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSS 545
Query: 636 --LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------D 673
+++P D +DL +SP R+ + P Q+P+ Q + + TP
Sbjct: 546 PSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTS 605
Query: 674 RSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 732
TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPG
Sbjct: 606 SPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPG 665
Query: 733 NYVKPL 738
NYV P+
Sbjct: 666 NYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 271 bits (694), Expect = 1e-72
Identities = 144/296 (48%), Positives = 189/296 (63%), Gaps = 52/296 (17%)
Query: 495 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 554
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 555 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 614
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 615 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 643
I GT RQGIFP +YV V + P +++P D
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
Query: 644 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 683
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
Query: 684 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 487 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 544
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
Query: 545 VGIFPRTYI 553
G FP Y+
Sbjct: 318 FGTFPGNYV 326
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
Query: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
Query: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
Query: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
Query: 730 FPGNYVKPLYL 740
FP NY++ L +
Sbjct: 720 FPKNYIQFLQI 730
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 522 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 576
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 577 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
Query: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
+D+P + R +S V R A + YI +
Sbjct: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
Query: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 571 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 630
Query: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 631 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 681
Query: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 682 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
Query: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
Query: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 600 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 644
Query: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
Query: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
Query: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
Query: 730 FPGNYVKPLYL 740
FP NY++ L +
Sbjct: 756 FPKNYIQFLQI 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 522 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 576
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 577 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
Query: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
+D+P + R +S V R A + YI +
Sbjct: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
Query: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 607 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 666
Query: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 667 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 717
Query: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 718 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
Query: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
Query: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 623 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 667
Query: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 698 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 736
Query: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
Query: 730 FPGNYVKPLYL 740
FP NY++ L +
Sbjct: 779 FPKNYIQFLQI 789
Score = 70.1 bits (170), Expect = 7e-12
Identities = 63/239 (26%), Positives = 106/239 (44%), Gaps = 38/239 (15%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 562
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
Query: 563 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 619
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
Query: 620 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 679
+ GIFP YV VI +D+P + R +S V R
Sbjct: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS--------HCVKGSRC---- 576
Query: 680 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 577 -----VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 630 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 689
Query: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 690 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 740
Query: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 741 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 94.7 bits (234), Expect = 3e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 577 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 636
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 637 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 694
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
Query: 695 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
Score = 69.7 bits (169), Expect = 9e-12
Identities = 71/300 (23%), Positives = 135/300 (45%), Gaps = 39/300 (13%)
Query: 451 RRLKREQEEADI---AARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 507
R +K+E ++ + A + +P+ + +++E +L + +R+ R +
Sbjct: 54 REIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSET---ILRTNKRGERRR----RRCQVA 106
Query: 508 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKK 566
F + Q EL L+ GDI+ + ++++ W+EG +G+ G+FP +I EL +++ +
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
Query: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
+ E + GD+ S +G T+ + ++ G IF
Sbjct: 167 DEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKD 221
Query: 627 TYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY- 684
+ + R + V+N D++ + + AT + TPD S+T D +
Sbjct: 222 KPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKS 268
Query: 685 ----QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+ ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 269 KDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 501 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 556
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 557 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 595
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 596 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 629
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 508 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 562
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 563 QPKKLTP 569
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 92.4 bits (228), Expect = 1e-18
Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)
Query: 510 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 568
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 569 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 619 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 673
+ G FP +V+++ P + NP D+P S + PQ+P PD
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
Query: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 731
QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G FP
Sbjct: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
Query: 732 GNYVKP 737
N+V P
Sbjct: 234 DNFVLP 239
Score = 66.6 bits (161), Expect = 8e-11
Identities = 52/210 (24%), Positives = 98/210 (46%), Gaps = 36/210 (17%)
Query: 502 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 558
R + F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP ++ELL PP
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 559 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 597
+ +P KL+ +Q + + E F++ + E++ R+G
Sbjct: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
Query: 598 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 655
+ + +L + D+ W+EG G R+G+FP + V+ P +K V + S+P +
Sbjct: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAPIKE 261
Query: 656 ------ATASPQQPQAQQRRVTPDRSQTSQ 679
T+ P + P +++TS+
Sbjct: 262 PKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)
Query: 577 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 635
E + + + E+S G+ + +R V W G G R G+FP V I
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
L + ++P+ +RR P + Q +SY P+
Sbjct: 60 L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
Query: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
DEL+L+ G+IV+++++ +DGW++G ++ Q G FP N+V+ L
Sbjct: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 83.6 bits (205), Expect = 6e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 564
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 565 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 622
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 623 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 682
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
Query: 683 S 683
S
Sbjct: 364 S 364
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 649 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 708
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
Query: 709 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 63.2 bits (152), Expect = 9e-10
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 644 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 703
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
Query: 704 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 554
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.066
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 556 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 614
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 615 IPGTSRQGIFPITYVDVIKR 634
T G+FP YV + R
Sbjct: 506 SLRTGVSGVFPGNYVTPVSR 525
Score = 35.8 bits (81), Expect = 0.15
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
Score = 33.1 bits (74), Expect = 0.96
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 588 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 630
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 553
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 564 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 619
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 620 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 667
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
Score = 77.4 bits (189), Expect = 4e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 635 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 694
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
Query: 695 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 684 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 499 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
Query: 552 YIE 554
++E
Sbjct: 884 FVE 886
Score = 38.9 bits (89), Expect = 0.017
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 579 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 638
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 639 NPVDYMDLPFSSSPSRSAT 657
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 35.4 bits (80), Expect = 0.19
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 517 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 553
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 33.1 bits (74), Expect = 0.96
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 738
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 3.6
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 588 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 632
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 80.9 bits (198), Expect = 4e-15
Identities = 70/236 (29%), Positives = 106/236 (44%), Gaps = 26/236 (11%)
Query: 504 ARAKFDFKAQTLKELPLQKGDIVYIY-KQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKA 562
A AK+DFKA EL ++GDI+ + ++ DQNWY+ E +G+ G P+ YIE+ P
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKP----- 57
Query: 563 QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQG 622
P + + E ++K +G + S +L + + ++ R G
Sbjct: 58 HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDG 114
Query: 623 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 682
++ V+K + VDY S+S SR+ Q+ D Q Q
Sbjct: 115 AGKY-FLWVVKFNSLNELVDYHR---STSVSRN-----------QQIFLRDIEQVPQQPT 159
Query: 683 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
QAL+ + PQ D EL R GD + VM+ D W+ G Q G FP NYV P+
Sbjct: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACH--GQTGMFPRNYVTPV 213
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/60 (33%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 577 EAIAKFNFNGDTQVEMSFRKGERITLL-RQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
EAIAK++F E+SF++G+ + +L + D+NWY+ + G + G P Y+++ P
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNG--KDGFIPKNYIEMKPHP 59
Score = 38.9 bits (89), Expect = 0.017
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 580 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 634
A F+F+ E+ FR+G+ I ++ D NW++G G + G+FP YV + R
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG--QTGMFPRNYVTPVNR 215
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 80.5 bits (197), Expect = 5e-15
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 566
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
Query: 567 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 623
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
Query: 624 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 682
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
Query: 683 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
Score = 70.5 bits (171), Expect = 5e-12
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 501 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 560
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 561 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 596
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 597 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 654
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 564
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 565 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 624
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 625 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 684
P + V + L S S +A Q P+ +
Sbjct: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
Query: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 79.3 bits (194), Expect = 1e-14
Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)
Query: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 564 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 619
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 620 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 672
+ GIFPI +V+ ++++ + +L SS SR T++ ++ +R+V
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 673 DRSQTS 678
S T+
Sbjct: 298 QFSITT 303
Score = 77.0 bits (188), Expect = 6e-14
Identities = 75/265 (28%), Positives = 111/265 (41%), Gaps = 55/265 (20%)
Query: 508 FDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
FD + + E L K DI+ + ++D+NW EG+ +VGIFP ++E
Sbjct: 198 FDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVE--------- 248
Query: 564 PKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ-- 621
LT +LE + + V S R G TL R PG+ R+
Sbjct: 249 -PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR-GNTSTLRRG----------PGSRRKVP 296
Query: 622 GIFPIT----------------YVDVIKRPL---------VKNPVDYMDLPFSSSPSRSA 656
G F IT ++ I P+ + P++ D+P SS + +
Sbjct: 297 GQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVP-SSCVGQVS 355
Query: 657 T--ASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 714
T +P P V+ SQ + AL+SY DEL+L+ G+ V V+ KC D
Sbjct: 356 TYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQD 415
Query: 715 GWFVGTSRRTKQFGTFPGNYVKPLY 739
GW G S T + G FP NYV P++
Sbjct: 416 GWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 36.6 bits (83), Expect = 0.086
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 654 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 713
R + +P++ QA R+ P+ + +AL +Y QN +L GDI+ + + D
Sbjct: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
Query: 714 DGWFVGTSRRTKQFGTFPGNYVK 736
+ W+ G G FP + V+
Sbjct: 160 ENWYQGEINGIS--GNFPASSVE 180
Score = 34.7 bits (78), Expect = 0.33
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)
Query: 579 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 634
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
Query: 635 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
P ++P Y S+S S S+ S + +Q R
Sbjct: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
Score = 33.9 bits (76), Expect = 0.56
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 553
A + A EL LQKG+ V + + W G GRVGIFP Y+
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 579 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 637
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
Query: 638 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 683
++ D LP +S R +T A QP Q + + +
Sbjct: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
Query: 684 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
Score = 57.4 bits (137), Expect = 5e-08
Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 46/300 (15%)
Query: 451 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 505
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 565
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
Query: 566 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 625
+V + GE D++ ++ I L V E G + T + I
Sbjct: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
Query: 626 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPDRSQT 677
I + D+ K VK L +S S + P++ P+ Q +T ++
Sbjct: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG 266
Query: 678 SQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNY 734
Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G FP N+
Sbjct: 267 KIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVFPDNF 324
Score = 36.6 bits (83), Expect = 0.086
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 681 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 738
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
Score = 35.8 bits (81), Expect = 0.15
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 562
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
Query: 563 QPKKLTP 569
PK P
Sbjct: 335 FPKPKKP 341
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 78.6 bits (192), Expect = 2e-14
Identities = 61/235 (25%), Positives = 99/235 (42%), Gaps = 37/235 (15%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 565
A + +++ +L Q+GD++ + K+ D +W+ G + G+FP Y+ L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 566 KLTPV-QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ- 621
K + + E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 622 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 681
G FP YV ++ SP S + P +S +
Sbjct: 1126 GWFPANYVKLL------------------SPGTSKITPTEPP----------KSTALAAV 1157
Query: 682 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+Y Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 69.7 bits (169), Expect = 9e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 54/254 (21%)
Query: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 562
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 563 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 607
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 608 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQ 667
+W+ G + + G+FP YV + S TA ++
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYVRL------------------KDSEGSGTAGKTGSLGKK 1075
Query: 668 RRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RT 724
+ Q + SY ++L L G ++ + +K GW+ G + +
Sbjct: 1076 PEIA-------------QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKK 1122
Query: 725 KQFGTFPGNYVKPL 738
+Q G FP NYVK L
Sbjct: 1123 RQIGWFPANYVKLL 1136
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 402 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 456
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 457 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 504
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 559
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 560 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 615
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 616 PGTSRQGIFPITYV 629
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/175 (28%), Positives = 80/175 (45%), Gaps = 26/175 (14%)
Query: 568 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 621
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQG--QK 958
Query: 622 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 681
G FP +YV +I P+ K+ MD S SP A +RV ++
Sbjct: 959 GWFPKSYVKLISGPIRKSTS--MDSGSSESP------------ASLKRVASPAAKPVVSG 1004
Query: 682 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ A+Y+Y +L + GD++ V +K D W+ GT + G FP NYV+
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTV--GDKAGVFPSNYVR 1056
Score = 53.9 bits (128), Expect = 5e-07
Identities = 130/660 (19%), Positives = 246/660 (37%), Gaps = 136/660 (20%)
Query: 149 LLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----EKPTSPGKAIEKRAKDDSRRVV 203
LL+ R++Q+RL+ L ER+ E+ + EK + +E++ +++ R+
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK-- 429
Query: 204 KSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSP 263
++ E +R +W R+ +L + R ED
Sbjct: 430 -------EIERREAAKRELERQRQLEW-----------ERNRRQELLNQRNKEQED---- 467
Query: 264 LSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPK 323
+ V ++K + + E + + L + + +++R + E +K + R
Sbjct: 468 IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELR------- 520
Query: 324 SIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFH-----AVKRESDGAP--- 375
I E + + +++M + P +I ++ + ++ H +KR +
Sbjct: 521 -IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELAR 579
Query: 376 ----GDLTSLENERQIYKSVLEGGDIPLQGLSGLK-----------RPSSSASTKDSESP 420
L +E E +S L+ DI L L+ + + K E
Sbjct: 580 QHLRDQLDEVEKET---RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE 636
Query: 421 RHFIPADYLESTEEFIRRRHDDKEKL----------------LADQRRLKREQ------- 457
R I LE +E +RR +++K L ++ +LKRE+
Sbjct: 637 RKIIE---LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
Query: 458 -EEADIAARRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARA 506
E+ A+ G + HQ + T E+ G L T + ++ RA
Sbjct: 694 EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRA 747
Query: 507 KFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPA 559
+ F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 560 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRIPG 617
E P K V + A A +T ++ E T NW + P
Sbjct: 808 EVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTWPT 859
Query: 618 TSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 676
++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 860 STNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV------ 913
Query: 677 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 914 ---EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 508 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.43
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 660 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 706
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 707 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 78.6 bits (192), Expect = 2e-14
Identities = 61/235 (25%), Positives = 99/235 (42%), Gaps = 37/235 (15%)
Query: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 565
A + +++ +L Q+GD++ + K+ D +W+ G + G+FP Y+ L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 566 KLTPV-QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ- 621
K + + E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 622 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 681
G FP YV ++ SP S + P +S +
Sbjct: 1126 GWFPANYVKLL------------------SPGTSKITPTEPP----------KSTALAAV 1157
Query: 682 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+Y Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 69.7 bits (169), Expect = 9e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 54/254 (21%)
Query: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 562
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 563 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 607
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 608 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQ 667
+W+ G + + G+FP YV + S TA ++
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYVRL------------------KDSEGSGTAGKTGSLGKK 1075
Query: 668 RRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RT 724
+ Q + SY ++L L G ++ + +K GW+ G + +
Sbjct: 1076 PEIA-------------QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKK 1122
Query: 725 KQFGTFPGNYVKPL 738
+Q G FP NYVK L
Sbjct: 1123 RQIGWFPANYVKLL 1136
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 402 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 456
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 457 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 504
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 559
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 560 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 615
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 616 PGTSRQGIFPITYV 629
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/175 (28%), Positives = 80/175 (45%), Gaps = 26/175 (14%)
Query: 568 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 621
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQG--QK 958
Query: 622 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 681
G FP +YV +I P+ K+ MD S SP A +RV ++
Sbjct: 959 GWFPKSYVKLISGPIRKSTS--MDSGSSESP------------ASLKRVASPAAKPVVSG 1004
Query: 682 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ A+Y+Y +L + GD++ V +K D W+ GT + G FP NYV+
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTV--GDKAGVFPSNYVR 1056
Score = 53.9 bits (128), Expect = 5e-07
Identities = 130/660 (19%), Positives = 246/660 (37%), Gaps = 136/660 (20%)
Query: 149 LLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----EKPTSPGKAIEKRAKDDSRRVV 203
LL+ R++Q+RL+ L ER+ E+ + EK + +E++ +++ R+
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK-- 429
Query: 204 KSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSP 263
++ E +R +W R+ +L + R ED
Sbjct: 430 -------EIERREAAKRELERQRQLEW-----------ERNRRQELLNQRNKEQED---- 467
Query: 264 LSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPK 323
+ V ++K + + E + + L + + +++R + E +K + R
Sbjct: 468 IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELR------- 520
Query: 324 SIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFH-----AVKRESDGAP--- 375
I E + + +++M + P +I ++ + ++ H +KR +
Sbjct: 521 -IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELAR 579
Query: 376 ----GDLTSLENERQIYKSVLEGGDIPLQGLSGLK-----------RPSSSASTKDSESP 420
L +E E +S L+ DI L L+ + + K E
Sbjct: 580 QHLRDQLDEVEKET---RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE 636
Query: 421 RHFIPADYLESTEEFIRRRHDDKEKL----------------LADQRRLKREQ------- 457
R I LE +E +RR +++K L ++ +LKRE+
Sbjct: 637 RKIIE---LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
Query: 458 -EEADIAARRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARA 506
E+ A+ G + HQ + T E+ G L T + ++ RA
Sbjct: 694 EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRA 747
Query: 507 KFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPA 559
+ F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 560 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRIPG 617
E P K V + A A +T ++ E T NW + P
Sbjct: 808 EVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTWPT 859
Query: 618 TSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 676
++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 860 STNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV------ 913
Query: 677 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
+ QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 914 ---EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 508 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.43
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 660 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 706
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 707 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,421,832
Number of Sequences: 37866
Number of extensions: 1504105
Number of successful extensions: 7165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 248
Number of HSP's that attempted gapping in prelim test: 5788
Number of HSP's gapped (non-prelim): 1251
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.