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Search of human proteins with 78000160
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
(684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 1372 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1335 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1311 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1241 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1159 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 877 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 632 0.0
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 431 e-121
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 424 e-118
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 413 e-115
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 408 e-113
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 402 e-112
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 375 e-104
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 297 2e-80
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 297 2e-80
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 284 2e-76
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 275 1e-73
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 110 4e-24
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 107 3e-23
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 106 8e-23
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 95 2e-19
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 92 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 84 6e-16
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 83 7e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 83 7e-16
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 2e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 81 4e-15
gi|39930351 dynamin binding protein [Homo sapiens] 80 5e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 80 8e-15
gi|11321634 CD2-associated protein [Homo sapiens] 79 2e-14
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 1372 bits (3550), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI
Sbjct: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
Query: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT
Sbjct: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
Query: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK
Sbjct: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
Query: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS
Sbjct: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
Query: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY
Sbjct: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
Query: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP
Sbjct: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
Query: 421 RHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNW 480
RHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNW
Sbjct: 421 RHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNW 480
Query: 481 YEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRK 540
YEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRK
Sbjct: 481 YEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRK 540
Query: 541 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSA 600
GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSA
Sbjct: 541 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSA 600
Query: 601 TASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGW 660
TASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGW
Sbjct: 601 TASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGW 660
Query: 661 FVGTSRRTKQFGTFPGNYVKPLYL 684
FVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 661 FVGTSRRTKQFGTFPGNYVKPLYL 684
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1335 bits (3456), Expect = 0.0
Identities = 683/740 (92%), Positives = 683/740 (92%), Gaps = 56/740 (7%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI
Sbjct: 61 TRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLI 120
Query: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT
Sbjct: 121 GTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT 180
Query: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK
Sbjct: 181 QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHK 240
Query: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS
Sbjct: 241 LNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 300
Query: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY
Sbjct: 301 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIY 360
Query: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP
Sbjct: 361 SSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESP 420
Query: 421 RHFIPADYLESTEEFIR---------------------------RRH------------- 440
RHFIPADYLESTEEFIR RRH
Sbjct: 421 RHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITN 480
Query: 441 ---------DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 484
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE
Sbjct: 481 ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 540
Query: 485 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 544
HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI
Sbjct: 541 HHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 600
Query: 545 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 604
TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP
Sbjct: 601 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 660
Query: 605 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 664
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
Query: 665 SRRTKQFGTFPGNYVKPLYL 684
SRRTKQFGTFPGNYVKPLYL
Sbjct: 721 SRRTKQFGTFPGNYVKPLYL 740
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1311 bits (3393), Expect = 0.0
Identities = 683/781 (87%), Positives = 683/781 (87%), Gaps = 97/781 (12%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 139
NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
Query: 140 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 199
TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
Sbjct: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
Query: 200 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 259
RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
Sbjct: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
Query: 260 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 319
TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
Sbjct: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
Query: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 379
AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
Sbjct: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
Query: 380 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR-- 437
SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
Query: 438 -------------------------RRH----------------------DD-------K 443
RRH DD
Sbjct: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
Query: 444 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 503
EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
Query: 504 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 563
EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
Sbjct: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
Query: 564 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 623
RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
Sbjct: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
Query: 624 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 683
DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
Sbjct: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
Query: 684 L 684
L
Sbjct: 781 L 781
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1241 bits (3210), Expect = 0.0
Identities = 680/905 (75%), Positives = 680/905 (75%), Gaps = 221/905 (24%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 100
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
Query: 101 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 145
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
Query: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
Query: 206 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 265
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
Query: 266 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 325
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI
Sbjct: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
Query: 326 YEYQPGKSSVLTNEKMS------------------------------------------- 342
YEYQPGKSSVLTNEKMS
Sbjct: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
Query: 343 -------SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
Query: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR------------------ 437
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
Query: 438 ---------RRH----------------------DD-------KEMRPARAKFDFKAQTL 459
RRH DD EMRPARAKFDFKAQTL
Sbjct: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
Query: 460 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 519
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
Query: 520 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 580 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 619
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 620 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 679
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 680 KPLYL 684
KPLYL
Sbjct: 901 KPLYL 905
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1159 bits (2999), Expect = 0.0
Identities = 579/580 (99%), Positives = 579/580 (99%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 237 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 296
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 297 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 356
Query: 225 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 284
ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR
Sbjct: 357 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 416
Query: 285 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 344
SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA
Sbjct: 417 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 476
Query: 345 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 404
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 477 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 536
Query: 405 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL 464
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL
Sbjct: 537 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL 596
Query: 465 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 524
QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA
Sbjct: 597 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 656
Query: 525 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 584
KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP
Sbjct: 657 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 716
Query: 585 VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL 644
VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL
Sbjct: 717 VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL 776
Query: 645 RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 684
RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 777 RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
Score = 254 bits (648), Expect = 2e-67
Identities = 233/756 (30%), Positives = 342/756 (45%), Gaps = 128/756 (16%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKP---------DEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSS-- 109
TRQHESKP DEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD++
Sbjct: 61 TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSS 120
Query: 110 ----PLLNEVSSSLIGTDS---------------QAFPSVSKPSSA-----YPSTTIVNP 145
P + V L+ TD P++ +SA +P+ P
Sbjct: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
Query: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
+ + Q R S P+S+ S P P +P + + + ++ D V S
Sbjct: 181 PHLQRWPHHSQPARASGSFAPISQ--TPPSFSPPPPLVPPAP-EDLRRVSEPDLTGAVSS 237
Query: 206 TQD---LSDVSMDEVGIPLRN----TERSKDWYKTMFKQ----IHKLNRDDD------SD 248
T L++VS +G + ++ S + T + + NR+ SD
Sbjct: 238 TDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSD 297
Query: 249 LYSPRYSFSEDT----KSPLSVPRSKSEMSYIDGEKVVKRSATL---PLPARSSSLKSSS 301
S R +D+ + P S ++ + + D +VVK + L + L+++
Sbjct: 298 PVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTE 357
Query: 302 ERNDWEPPDKKVDTRKYRAEPKSI----YEYQPGKSSVLTNEKMSSAIS-----PTPEIS 352
DW K + R + + Y + S L+ + S +S + S
Sbjct: 358 RSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRS 417
Query: 353 SETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSS 411
+ P SS+ + +D P D R KS+ E L+ K S+
Sbjct: 418 ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAI 477
Query: 412 ASTKD--SESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDI 469
+ T + SE+P + +++ ++R D P + + + L+ GDI
Sbjct: 478 SPTPEISSETPGYIYSSNF-----HAVKRESDG---APGDLTSLENERQIYKSVLEGGDI 529
Query: 470 ----VYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP--AEKAQPKKLTPVQVLEYGEAI 523
+ K+ + + P Y+E + K++ P A
Sbjct: 530 PLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRP--------AR 581
Query: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 583
AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------- 632
Query: 584 PVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 643
P +AQ +++TP + + A +++ E+
Sbjct: 633 --------------------PPAEKAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMS 669
Query: 644 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 679
R G+ + ++ + D+ W+ G T + G FP YV
Sbjct: 670 FRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 877 bits (2266), Expect = 0.0
Identities = 494/698 (70%), Positives = 500/698 (71%), Gaps = 187/698 (26%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
Query: 225 ERSKDWYKTMFKQIHKLNRD---------------------------------------- 244
ERSKDWYKTMFKQIHKLNRD
Sbjct: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTP 448
Query: 245 ------DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 298
DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK
Sbjct: 449 SPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 508
Query: 299 SSSERNDWEPPDKKVDTRKYRAEP------------------------------------ 322
SSSERNDWEPPDKKVDTRKYRAEP
Sbjct: 509 SSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWY 568
Query: 323 -------------KSIYEYQPGKSSVL------TN----------------EKM------ 341
K I++Y PG S+L TN EKM
Sbjct: 569 KFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKA 628
Query: 342 -------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 394
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG
Sbjct: 629 PSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 688
Query: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR----------------- 437
GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 689 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 748
Query: 438 ----------RRH----------------------DD-------KEMRPARAKFDFKAQT 458
RRH DD EMRPARAKFDFKAQT
Sbjct: 749 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
Query: 459 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 518
LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE
Sbjct: 809 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 868
Query: 519 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 578
YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR
Sbjct: 869 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928
Query: 579 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616
PLVKNPVDYMDLPFSSSPSRSATASPQ + + +TP
Sbjct: 929 PLVKNPVDYMDLPFSSSPSRSATASPQF-SSHSKLITP 965
Score = 197 bits (500), Expect = 3e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 134 SSAYPSTTIVNPTI 147
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 170 bits (430), Expect = 5e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 605 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 664
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
Query: 665 SRRTKQFGTFPGNYVKPLYL 684
SRRTKQFGTFPGNYVKPLYL
Sbjct: 1273 SRRTKQFGTFPGNYVKPLYL 1292
Score = 33.1 bits (74), Expect = 0.87
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 438 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 495
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
Query: 496 YIELL 500
Y++ L
Sbjct: 1286 YVKPL 1290
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 677
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 678 YVKPL 682
Y++ L
Sbjct: 846 YIELL 850
Score = 32.0 bits (71), Expect = 1.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 505 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 561
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 562 TSRQGIFPITYV 573
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 632 bits (1630), Expect = 0.0
Identities = 354/502 (70%), Positives = 357/502 (71%), Gaps = 140/502 (27%)
Query: 244 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 303
DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER
Sbjct: 476 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 535
Query: 304 NDWEPPDKKVDTRKYRAEP----------------------------------------- 322
NDWEPPDKKVDTRKYRAEP
Sbjct: 536 NDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE 595
Query: 323 --------KSIYEYQPGKSSVL------TN----------------EKM----------- 341
K I++Y PG S+L TN EKM
Sbjct: 596 LEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANV 655
Query: 342 --SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 399
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL
Sbjct: 656 PQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 715
Query: 400 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR---------------------- 437
QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 716 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 775
Query: 438 -----RRH----------------------DD-------KEMRPARAKFDFKAQTLKELP 463
RRH DD EMRPARAKFDFKAQTLKELP
Sbjct: 776 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 835
Query: 464 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 523
LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI
Sbjct: 836 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 895
Query: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 583
AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN
Sbjct: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 955
Query: 584 PVDYMDLPFSSSPSRSATASPQ 605
PVDYMDLPFSSSPSRSATASPQ
Sbjct: 956 PVDYMDLPFSSSPSRSATASPQ 977
Score = 286 bits (731), Expect = 6e-77
Identities = 247/686 (36%), Positives = 323/686 (47%), Gaps = 120/686 (17%)
Query: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
Query: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
Query: 225 ERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEM 273
ERSKDWYKTMFKQIHKLNRD + + Y P Y F SE+TKS + PR +
Sbjct: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSG 448
Query: 274 SYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQ-- 329
+ I + ++ P + S ++ + +D P DT+ + P+S E
Sbjct: 449 TVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYI 508
Query: 330 --------------PGKSS---------------------------------------VL 336
P +SS VL
Sbjct: 509 DGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVL 568
Query: 337 TNEKMSSAISPTPEISSETPGYIYSSNFH----AVKRESDGAPGDL---------TSLEN 383
TNEKMS ISP P Y + S K+ D PGD T+L+
Sbjct: 569 TNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDK 628
Query: 384 ERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPAD---YLESTEEFIRRRH 440
+ + ++ LE ++ L+ K PS++ + SP I ++ Y+ S+ +R
Sbjct: 629 DLSLCQTELEADLEKMETLN--KAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRE 686
Query: 441 DDKEMRPARAKFDFKAQTLKELPLQKGDI----VYIYKQIDQNWYEGEHHGRVGIFPRTY 496
D + + Q K + L+ GDI + K+ + + P Y
Sbjct: 687 SDGAPGDL-TSLENERQIYKSV-LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADY 744
Query: 497 I----ELLPPAEKAQPKKLTPVQVL--EYGEA-IAKFNFNGDTQVEMSFRKGERITLLRQ 549
+ E + + K L + L E EA IA G F ER L
Sbjct: 745 LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLN 804
Query: 550 VDENWYEGRIPGTS---RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSS----------- 595
+D+ R G+ + F + + PL K + Y+ +
Sbjct: 805 IDDT--AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 862
Query: 596 --PSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 653
P P +AQ +++TP + + A +++ E+ R G+ + ++
Sbjct: 863 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLL 919
Query: 654 EKCDDGWFVGTSRRTKQFGTFPGNYV 679
+ D+ W+ G T + G FP YV
Sbjct: 920 RQVDENWYEGRIPGTSRQGIFPITYV 945
Score = 197 bits (500), Expect = 3e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 134 SSAYPSTTIVNPTI 147
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 196 bits (498), Expect = 6e-50
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 444 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 501
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 502 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 544
P + + P + + E ++ + G +I
Sbjct: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
Query: 545 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 593
T R D N E PG FP + + +R
Sbjct: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
Query: 594 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 653
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
Query: 654 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 684
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 33.1 bits (74), Expect = 0.87
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 438 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 495
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 496 YIELL 500
Y++ L
Sbjct: 1145 YVKPL 1149
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 677
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 678 YVKPL 682
Y++ L
Sbjct: 868 YIELL 872
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 431 bits (1109), Expect = e-121
Identities = 281/653 (43%), Positives = 367/653 (56%), Gaps = 44/653 (6%)
Query: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
Query: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
Query: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
Query: 227 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGE 279
KDWYKTMFKQIH +++ LY+P YS T PLS S S ++ D
Sbjct: 180 PKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 236
Query: 280 KVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 338
V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 237 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 296
Query: 339 EKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----L 392
E+ +S + + S E P +S+F +R+S+ A G L ++ S L
Sbjct: 297 ERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDL 355
Query: 393 EGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARA 450
G L PSS + KD ESPR + D S RR +KE PA+A
Sbjct: 356 PGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKA 414
Query: 451 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 510
+DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +
Sbjct: 415 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 474
Query: 511 LTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 569
P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP
Sbjct: 475 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP 534
Query: 570 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQ 629
++YV+V+K+ K DY D P S S S + Q+ T + Q + F Q
Sbjct: 535 VSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--Q 591
Query: 630 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
ALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 592 ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 424 bits (1090), Expect = e-118
Identities = 274/675 (40%), Positives = 370/675 (54%), Gaps = 72/675 (10%)
Query: 62 RQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSS 118
R +S WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 5 RDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSG 64
Query: 119 LIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA 178
+ + PS AY +N +IV+ Q S S + D
Sbjct: 65 GAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGT 116
Query: 179 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMF 235
+ P EKR V+K+ +DE GIP +R T +R KDWYKTMF
Sbjct: 117 TSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMF 171
Query: 236 KQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKR 284
KQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D +
Sbjct: 172 KQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK 231
Query: 285 SATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSV 335
A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 232 DASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI 291
Query: 336 LTNEKMSSAISPTPEISSETPGYIYSSNFHAV---------------------KRESDGA 374
L +E+ P + + G ++ + +R+S+ A
Sbjct: 292 LQHERPPPK-KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 350
Query: 375 PGDLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DY 428
G L ++ S L G L PSS + KD ESPR + D
Sbjct: 351 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 410
Query: 429 LESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 488
S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGR
Sbjct: 411 GRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 469
Query: 489 VGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLL 547
VGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL
Sbjct: 470 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 529
Query: 548 RQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQP 607
++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 530 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSN 588
Query: 608 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 667
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRR
Sbjct: 589 KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 646
Query: 668 TKQFGTFPGNYVKPL 682
TK FGTFPGNYVK L
Sbjct: 647 TKFFGTFPGNYVKRL 661
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 413 bits (1061), Expect = e-115
Identities = 269/680 (39%), Positives = 363/680 (53%), Gaps = 95/680 (13%)
Query: 81 GNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPST 140
G S +AKG+RSV PNL +S S + +S + + PS AY
Sbjct: 4 GRDSQSPDSAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPS-AYSLP 62
Query: 141 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSR 200
+N +IV+ Q S S + D + P EKR
Sbjct: 63 ASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT---- 111
Query: 201 RVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSF 256
V+K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y++
Sbjct: 112 -VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTY 170
Query: 257 SEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL--------- 297
+ +P S P +K++ S+ D + A+ P+P
Sbjct: 171 NAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRD 230
Query: 298 KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPG 357
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P P
Sbjct: 231 RSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPW 290
Query: 358 YIYSSNFH----AVKRESDGAPGDLTSLENERQIYKSVLEG------------------- 394
Y + S K+ D + + NE +Y+S ++
Sbjct: 291 YKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 350
Query: 395 ----------------------GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIP 425
G + L G S PSS + KD ESPR +
Sbjct: 351 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 410
Query: 426 A--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG 483
D S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEG
Sbjct: 411 TLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG 469
Query: 484 EHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGE 542
EHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+
Sbjct: 470 EHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGD 529
Query: 543 RITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATA 602
R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 530 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIH 588
Query: 603 SPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 662
S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 589 SLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 646
Query: 663 GTSRRTKQFGTFPGNYVKPL 682
GTSRRTK FGTFPGNYVK L
Sbjct: 647 GTSRRTKFFGTFPGNYVKRL 666
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 408 bits (1048), Expect = e-113
Identities = 233/492 (47%), Positives = 311/492 (63%), Gaps = 34/492 (6%)
Query: 220 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 273
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 274 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 319
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
Query: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 377
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
Query: 378 LTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLES 431
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 185 PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRS 244
Query: 432 TEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGI 491
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGI
Sbjct: 245 APRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 303
Query: 492 FPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 550
FP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++V
Sbjct: 304 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 363
Query: 551 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 610
D+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q
Sbjct: 364 DQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQ 422
Query: 611 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 670
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
Query: 671 FGTFPGNYVKPL 682
FGTFPGNYVK L
Sbjct: 481 FGTFPGNYVKRL 492
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 402 bits (1033), Expect = e-112
Identities = 279/740 (37%), Positives = 380/740 (51%), Gaps = 131/740 (17%)
Query: 53 SSPASPQETRQHESKPDEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS 109
SSP R +S WR + + NG+A SSLAAKG+RSV PNL +S S
Sbjct: 13 SSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQS 72
Query: 110 PLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSE 169
+ +S + + PS AY +N +IV+ Q S S
Sbjct: 73 QITVNGNSGGAVSPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYP 124
Query: 170 RRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ER 226
+ D + P EKR V+K+ +DE GIP +R T +R
Sbjct: 125 QHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDR 179
Query: 227 SKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SY 275
KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++ S+
Sbjct: 180 PKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSH 239
Query: 276 IDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIY 326
D + A+ P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+
Sbjct: 240 SDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIF 299
Query: 327 EYQ-------------------------PGKSSVLTNE--KMSSAISPTPEISSETPGYI 359
EY+ PG+ + ++ +++ + SP P + TP
Sbjct: 300 EYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP--- 356
Query: 360 YSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEG------------------- 394
SS A+ K+ D + + NE +Y+S ++
Sbjct: 357 -SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 415
Query: 395 ----------------------GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIP 425
G + L G S PSS + KD ESPR +
Sbjct: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
Query: 426 A--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG 483
D S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEG
Sbjct: 476 TLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG 534
Query: 484 EHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGE 542
EHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+
Sbjct: 535 EHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGD 594
Query: 543 RITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATA 602
R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 595 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIH 653
Query: 603 SPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 662
S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 654 SLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 711
Query: 663 GTSRRTKQFGTFPGNYVKPL 682
GTSRRTK FGTFPGNYVK L
Sbjct: 712 GTSRRTKFFGTFPGNYVKRL 731
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 375 bits (962), Expect = e-104
Identities = 240/598 (40%), Positives = 330/598 (55%), Gaps = 117/598 (19%)
Query: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
Query: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQ------------------- 329
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+
Sbjct: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
Query: 330 ------PGKSSVLTNE--KMSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 375
PG+ + ++ +++ + SP P + TP SS A+ K+ D
Sbjct: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
Query: 376 GDLTSLENERQIYKSVLEG----------------------------------------- 394
+ + NE +Y+S ++
Sbjct: 471 DHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSP 530
Query: 395 GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEM 445
G + L G S PSS + KD ESPR + D S RR +KE
Sbjct: 531 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEK 589
Query: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 505
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EK
Sbjct: 590 LPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEK 649
Query: 506 AQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 564
AQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+R
Sbjct: 650 AQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR 709
Query: 565 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQD 624
QGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q +
Sbjct: 710 QGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
Query: 625 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 297 bits (760), Expect = 2e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 415 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 472
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 738 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 796
Query: 473 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 531
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 797 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 856
Query: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 591
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 857 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 915
Query: 592 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 651
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 973
Query: 652 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 974 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 113 bits (283), Expect = 5e-25
Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)
Query: 220 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 272
PL+ +R KDWYKTMFKQIH +++ LY+P YS T PLS S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
Query: 273 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 331
++ D V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 63 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 332 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 389
KSS+L +E+ +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
Query: 390 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 419
S G + L G S S ++S+ S S
Sbjct: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 297 bits (760), Expect = 2e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 415 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 472
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 834 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 892
Query: 473 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 531
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 893 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 952
Query: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 591
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 953 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 1011
Query: 592 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 651
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 1069
Query: 652 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1070 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 121 bits (303), Expect = 2e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 194 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 247
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 248 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 297
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
Query: 298 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 348
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
Query: 349 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 406
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
Query: 407 RPSSSASTKDSES 419
S ++S+ S S
Sbjct: 292 TKSFTSSSPSSPS 304
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 284 bits (727), Expect = 2e-76
Identities = 201/570 (35%), Positives = 283/570 (49%), Gaps = 90/570 (15%)
Query: 196 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 250
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
Query: 251 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER--- 303
PR+ ++ + P + S D + + RS P S++ S +
Sbjct: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLR 228
Query: 304 ------NDW--EPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSET 355
N W E ++ + + PK PG+ E + E+S+E
Sbjct: 229 RREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLER--ELAELSAEL 286
Query: 356 PGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTK 415
+ + +S AP + E + P G R S
Sbjct: 287 DKDLRAIETRLPSPKSSPAPR--RAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMA 344
Query: 416 DSESP----RHFIPADYLESTEEFIRR-------RHDDKEMRPARAKFDFKAQTLKELPL 464
D SP R F+ Y ST + R ++K+ + AR KFDF+AQ+ KEL L
Sbjct: 345 DGGSPFLGRRDFV---YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTL 401
Query: 465 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 524
QKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E +P K QVLEYGEA+A
Sbjct: 402 QKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVA 461
Query: 525 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP----- 579
++ F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 462 QYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLC 521
Query: 580 --------------------------LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQR 612
+++P D +DL +SP R+ + P Q+P+ Q +
Sbjct: 522 DDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQ 581
Query: 613 RV-TP------------------DRSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDV 652
+ TP TSQ ++ Y+A+Y Y PQN+DELELR+GD VDV
Sbjct: 582 NLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDV 641
Query: 653 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
M++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 642 MQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 275 bits (703), Expect = 1e-73
Identities = 145/296 (48%), Positives = 191/296 (64%), Gaps = 52/296 (17%)
Query: 439 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 498
R ++K+ + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 499 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 558
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 559 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 587
I GT RQGIFP +YV V + P +++P D
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
Query: 588 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 627
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
Query: 628 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 110 bits (275), Expect = 4e-24
Identities = 133/620 (21%), Positives = 248/620 (40%), Gaps = 106/620 (17%)
Query: 90 AKGYRSVHPNLPSDKSQ---DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPT 146
AK Y+S+ P++ S PL V LI D P+ PS ++ +
Sbjct: 176 AKAYKSLGEGPPANPPVPVLQSKPL---VDIDLISFDDDVLPT---PSGNLAEESVGSEM 229
Query: 147 IVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRAKDDSRR 201
++ +L + ++P+ ER V APT++ P PGK + + +
Sbjct: 230 VL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDPQSPPPL 279
Query: 202 VVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTK 261
+ P+ NT + T+ ++ + R + + P +
Sbjct: 280 PAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRV 319
Query: 262 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 321
P PR + + + K P P + S+ + S+++ + +D +K ++
Sbjct: 320 PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSN 379
Query: 322 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNF-----HAVKRES--DGA 374
+ KS V N+ + P P+ PG+ S + H + E
Sbjct: 380 LAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMLSVPHGIANEDIVSQN 430
Query: 375 PGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPR-HFIPADYLESTE 433
PG+L+ + + E + Q K ++ R H + +
Sbjct: 431 PGELSCKRGDVLVMLKQTENNYLECQ--------------KGEDTGRVHLSQMKIITPLD 476
Query: 434 EFIRRRHDDKE--MRP-------ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 484
E +R R +D +P A DF A+ + +L L G+IVY+ ++ID +WY G
Sbjct: 477 EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 536
Query: 485 HHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGE 542
++GIFP Y++++ P ++ ++ +A+F + G+ + E+SF +GE
Sbjct: 537 CRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 596
Query: 543 RITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATA 602
I L V+E W G + G R GIFP+ +V+ ++ D P S +
Sbjct: 597 IIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVL 639
Query: 603 SPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWF 661
S + P ++ + SQ + + +AL+S+ + D+L + GD + ++E+ D W
Sbjct: 640 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 699
Query: 662 VGTSRRTKQFGTFPGNYVKP 681
G R + G FP +V+P
Sbjct: 700 RG--RLQDREGIFPAVFVRP 717
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP------- 502
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 503 ---------AEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 698 WCRGRLQ--DREGIFPAVFV----RPC---------------PAEAKSMLAIVPKGRKAK 736
Query: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
Query: 674 FPGNYVKPLYL 684
FP NY++ L +
Sbjct: 779 FPKNYIQFLQI 789
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 733 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 107 bits (268), Expect = 3e-23
Identities = 132/606 (21%), Positives = 239/606 (39%), Gaps = 101/606 (16%)
Query: 90 AKGYRSVHPNLPSDKSQ---DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPT 146
AK Y+S+ P++ S PL V LI D P+ PS ++ +
Sbjct: 176 AKAYKSLGEGPPANPPVPVLQSKPL---VDIDLISFDDDVLPT---PSGNLAEESVGSEM 229
Query: 147 IVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRAKDDSRR 201
++ +L + ++P+ ER V APT++ P PGK + + +
Sbjct: 230 VL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDPQSPPPL 279
Query: 202 VVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTK 261
+ P+ NT + T+ ++ + R + + P +
Sbjct: 280 PAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRV 319
Query: 262 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 321
P PR + + + K P P + S+ + S+++ + +D +K ++
Sbjct: 320 PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSN 379
Query: 322 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTS 380
+ KS V N+ + P P+ PG+ S + GD L
Sbjct: 380 LAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR---------GDVLVM 421
Query: 381 LENERQIYKSVLEGGDIPLQGLSGLK--RPSSSASTKDSESPRHFIPADYLESTEEFIRR 438
L+ Y +G D LS +K P P H +
Sbjct: 422 LKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSH--------------AQ 467
Query: 439 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 498
+ D A DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++
Sbjct: 468 KPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVK 527
Query: 499 LL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYE 556
++ P ++ ++ +A+F + G+ + E+SF +GE I L V+E W
Sbjct: 528 VIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWAR 587
Query: 557 GRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616
G + G R GIFP+ +V+ ++ D P S + S + P ++ +
Sbjct: 588 GEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSG 630
Query: 617 DRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 675
SQ + + +AL+S+ + D+L + GD + ++E+ D W G R + G FP
Sbjct: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFP 688
Query: 676 GNYVKP 681
+V+P
Sbjct: 689 AVFVRP 694
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 501
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 502 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
Query: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
Query: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
Query: 674 FPGNYVKPLYL 684
FP NY++ L +
Sbjct: 756 FPKNYIQFLQI 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 466 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 520
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 521 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
Query: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639
+D+P + R +S V R A + YI +
Sbjct: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
Query: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 710 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 106 bits (264), Expect = 8e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 453 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 510
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 511 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 570
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 571 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 629
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
Query: 630 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 681
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 501
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 502 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
Query: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
Query: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
Query: 674 FPGNYVKPLYL 684
FP NY++ L +
Sbjct: 720 FPKNYIQFLQI 730
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 466 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 520
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 521 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
Query: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639
+D+P + R +S V R A + YI +
Sbjct: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
Query: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 674 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 521 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 580
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 581 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 638
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
Query: 639 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
Score = 77.8 bits (190), Expect = 3e-14
Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)
Query: 413 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 470
+ K E P H +P+ + L S+E +R + ++ R + F + Q EL L+ GDI+
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125
Query: 471 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 529
+ ++++ W+EG +G+ G+FP +I EL +++ + + E +
Sbjct: 126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 185
Query: 530 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 588
GD+ S +G T+ + ++ G IF + + R + V+N D++
Sbjct: 186 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 238
Query: 589 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 643
+ + AT + TPD S+T D + + ++ Y QNDDEL
Sbjct: 239 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 287
Query: 644 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 682
+++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 288 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 445 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 500
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 501 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 539
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 540 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 573
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
Score = 57.0 bits (136), Expect = 6e-08
Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)
Query: 392 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 451
+E +P++ G K P+++A+ S+ TE R + D +
Sbjct: 233 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 275
Query: 452 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 506
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 507 QPKKLTP 513
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 92.4 bits (228), Expect = 1e-18
Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)
Query: 454 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 512
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 513 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 562
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 563 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 617
+ G FP +V+++ P + NP D+P S + PQ+P PD
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
Query: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 675
QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G FP
Sbjct: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
Query: 676 GNYVKP 681
N+V P
Sbjct: 234 DNFVLP 239
Score = 72.4 bits (176), Expect = 1e-12
Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 39/222 (17%)
Query: 437 RRRHDDKEMRPAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 493
RR H K RP R F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 494 RTYIELL---PPA-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFN 529
++ELL PP+ +P KL+ +Q + + E F++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 530 GDTQVEMSFRKGERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDY 587
+ E++ R+G+ + +L + D+ W+EG G R+G+FP + V+ P +K V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPR 249
Query: 588 MDLPFSSSPSRS------ATASPQQPQAQQRRVTPDRSQTSQ 623
+ S+P + T+ P + P +++TS+
Sbjct: 250 KVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)
Query: 521 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 579
E + + + E+S G+ + +R V W G G R G+FP V I
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639
L + ++P+ +RR P + Q +SY P+
Sbjct: 60 L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
Query: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
DEL+L+ G+IV+++++ +DGW++G ++ Q G FP N+V+ L
Sbjct: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 83.6 bits (205), Expect = 6e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 509 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 566
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 567 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 626
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
Query: 627 S 627
S
Sbjct: 364 S 364
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 593 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 652
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
Query: 653 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 63.2 bits (152), Expect = 8e-10
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 588 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 647
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
Query: 648 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 498
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.061
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 500 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 558
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 559 IPGTSRQGIFPITYVDVIKR 578
T G+FP YV + R
Sbjct: 506 SLRTGVSGVFPGNYVTPVSR 525
Score = 35.8 bits (81), Expect = 0.13
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
Score = 33.1 bits (74), Expect = 0.87
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 574
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 32.7 bits (73), Expect = 1.1
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 497
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 83.2 bits (204), Expect = 7e-16
Identities = 76/288 (26%), Positives = 118/288 (40%), Gaps = 55/288 (19%)
Query: 402 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEMRPARAKFDFKA 456
+SG R S+S + SESP A + S EEFI A + +++
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFI-------------AMYTYES 1015
Query: 457 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPV-Q 515
+L Q+GD++ + K+ D +W+ G + G+FP Y+ L K + +
Sbjct: 1016 SEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGK 1074
Query: 516 VLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFPITY 572
E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ G FP Y
Sbjct: 1075 KPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 573 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALY 632
V ++ SP S + P +S + +Y
Sbjct: 1133 VKLL------------------SPGTSKITPTEPP----------KSTALAAVCQVIGMY 1164
Query: 633 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 54/279 (19%)
Query: 423 FIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE 482
F PA S+ + + + E A+A + ++A+ L K D++ + +Q D W+
Sbjct: 893 FTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF- 951
Query: 483 GEHHGRVGIFPRTYIELLP-PAEKA---------QPKKLTPV------QVLEYGEAIAKF 526
GE G+ G FP++Y++L+ P K+ P L V V+ E IA +
Sbjct: 952 GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMY 1011
Query: 527 NFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVD 586
+ Q +++F++G+ + L+ + D +W+ G + + G+FP YV +
Sbjct: 1012 TYESSEQGDLTFQQGD-VILVTKKDGDWWTGTV--GDKAGVFPSNYVRL----------- 1057
Query: 587 YMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRD 646
S TA ++ + Q + SY ++L L
Sbjct: 1058 -------KDSEGSGTAGKTGSLGKKPEIA-------------QVIASYTATGPEQLTLAP 1097
Query: 647 GDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 682
G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1098 GQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 53.1 bits (126), Expect = 8e-07
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 30/242 (12%)
Query: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLP 501
RA + F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 502 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRI 559
E P K V + A A +T ++ E T NW +
Sbjct: 806 ENEVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTW 857
Query: 560 PGTSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDR 618
P ++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 858 PTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV---- 913
Query: 619 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 678
+ QALY + + D+ L D++ V+E+ D WF Q G FP +Y
Sbjct: 914 -----EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSY 965
Query: 679 VK 680
VK
Sbjct: 966 VK 967
Score = 49.7 bits (117), Expect = 9e-06
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 452 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.39
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 604 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 650
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 651 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 83.2 bits (204), Expect = 7e-16
Identities = 76/288 (26%), Positives = 118/288 (40%), Gaps = 55/288 (19%)
Query: 402 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEMRPARAKFDFKA 456
+SG R S+S + SESP A + S EEFI A + +++
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFI-------------AMYTYES 1015
Query: 457 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPV-Q 515
+L Q+GD++ + K+ D +W+ G + G+FP Y+ L K + +
Sbjct: 1016 SEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGK 1074
Query: 516 VLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFPITY 572
E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ G FP Y
Sbjct: 1075 KPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 573 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALY 632
V ++ SP S + P +S + +Y
Sbjct: 1133 VKLL------------------SPGTSKITPTEPP----------KSTALAAVCQVIGMY 1164
Query: 633 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 54/279 (19%)
Query: 423 FIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE 482
F PA S+ + + + E A+A + ++A+ L K D++ + +Q D W+
Sbjct: 893 FTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF- 951
Query: 483 GEHHGRVGIFPRTYIELLP-PAEKA---------QPKKLTPV------QVLEYGEAIAKF 526
GE G+ G FP++Y++L+ P K+ P L V V+ E IA +
Sbjct: 952 GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMY 1011
Query: 527 NFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVD 586
+ Q +++F++G+ + L+ + D +W+ G + + G+FP YV +
Sbjct: 1012 TYESSEQGDLTFQQGD-VILVTKKDGDWWTGTV--GDKAGVFPSNYVRL----------- 1057
Query: 587 YMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRD 646
S TA ++ + Q + SY ++L L
Sbjct: 1058 -------KDSEGSGTAGKTGSLGKKPEIA-------------QVIASYTATGPEQLTLAP 1097
Query: 647 GDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 682
G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1098 GQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 53.1 bits (126), Expect = 8e-07
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 30/242 (12%)
Query: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLP 501
RA + F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 502 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRI 559
E P K V + A A +T ++ E T NW +
Sbjct: 806 ENEVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTW 857
Query: 560 PGTSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDR 618
P ++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 858 PTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV---- 913
Query: 619 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 678
+ QALY + + D+ L D++ V+E+ D WF Q G FP +Y
Sbjct: 914 -----EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSY 965
Query: 679 VK 680
VK
Sbjct: 966 VK 967
Score = 49.7 bits (117), Expect = 9e-06
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 452 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.39
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 604 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 650
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 651 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 448 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 508 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 563
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 564 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 611
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
Score = 77.4 bits (189), Expect = 4e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 579 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 638
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
Query: 639 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 628 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 46.6 bits (109), Expect = 8e-05
Identities = 44/191 (23%), Positives = 77/191 (40%), Gaps = 41/191 (21%)
Query: 342 SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQG 401
SSA P + E G + + + KR+ +P +LE E L ++PLQG
Sbjct: 703 SSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVE-------LGSAELPLQG 755
Query: 402 LSGLKRPSSSASTK------DSESPRHFIPADYLESTEEFIRRRHDD------------- 442
G + P + D + P A + + F R+
Sbjct: 756 AVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQA 815
Query: 443 --------KEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHG 487
E RP R + Q+ EL L++GDIV+++K+ + W++G + +G
Sbjct: 816 CSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNG 875
Query: 488 RVGIFPRTYIE 498
+ G+FP +++E
Sbjct: 876 KTGLFPGSFVE 886
Score = 38.9 bits (89), Expect = 0.016
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 523 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 582
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 583 NPVDYMDLPFSSSPSRSAT 601
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 37.0 bits (84), Expect = 0.061
Identities = 56/238 (23%), Positives = 91/238 (38%), Gaps = 35/238 (14%)
Query: 289 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEY-QPGKSSVLTNEKMSSAISP 347
P+P + SS+ P K DT+K + S KSS + + S ISP
Sbjct: 270 PVPGVDAGECSSAAAQSSTAP-KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
Query: 348 TPEISSETPGYIYSSNFHAVKRESDGAPGDL----TSLENERQIYKSVLEG------GDI 397
ISS P ++ + S AP + T L V G D+
Sbjct: 329 PVLISSSNP--TAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDV 386
Query: 398 PLQGLSG-----LKRPSSSASTKDSESPRHFI---------PADYLESTEEFIRRRHDDK 443
P Q G L P A+T + +P P ST++ R
Sbjct: 387 PYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLR---P 443
Query: 444 EMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 497
+ RP+ A + + + EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 444 QTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 33.1 bits (74), Expect = 0.87
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 682
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 3.3
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 576
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 80.9 bits (198), Expect = 4e-15
Identities = 70/236 (29%), Positives = 106/236 (44%), Gaps = 26/236 (11%)
Query: 448 ARAKFDFKAQTLKELPLQKGDIVYIY-KQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKA 506
A AK+DFKA EL ++GDI+ + ++ DQNWY+ E +G+ G P+ YIE+ P
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKP----- 57
Query: 507 QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQG 566
P + + E ++K +G + S +L + + ++ R G
Sbjct: 58 HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDG 114
Query: 567 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 626
++ V+K + VDY S+S SR+ Q+ D Q Q
Sbjct: 115 AGKY-FLWVVKFNSLNELVDYHR---STSVSRN-----------QQIFLRDIEQVPQQPT 159
Query: 627 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
QAL+ + PQ D EL R GD + VM+ D W+ G Q G FP NYV P+
Sbjct: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACH--GQTGMFPRNYVTPV 213
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/60 (33%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 521 EAIAKFNFNGDTQVEMSFRKGERITLL-RQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
EAIAK++F E+SF++G+ + +L + D+NWY+ + G + G P Y+++ P
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNG--KDGFIPKNYIEMKPHP 59
Score = 38.9 bits (89), Expect = 0.016
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 578
A F+F+ E+ FR+G+ I ++ D NW++G G + G+FP YV + R
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG--QTGMFPRNYVTPVNR 215
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 80.5 bits (197), Expect = 5e-15
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 453 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 510
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
Query: 511 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 567
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
Query: 568 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 626
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
Query: 627 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
Score = 70.5 bits (171), Expect = 5e-12
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 445 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 504
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 505 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 540
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 541 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 598
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 509 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 568
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 569 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 628
P + V + L S S +A Q P+ +
Sbjct: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
Query: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 79.7 bits (195), Expect = 8e-15
Identities = 80/293 (27%), Positives = 122/293 (41%), Gaps = 55/293 (18%)
Query: 424 IPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQN 479
I ++ S+ E I++ + A FD + + E L K DI+ + ++D+N
Sbjct: 170 ISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDEN 229
Query: 480 WYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFR 539
W EG+ +VGIFP ++E LT +LE + + V S R
Sbjct: 230 WAEGKLGDKVGIFPILFVE----------PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR 279
Query: 540 KGERITLLRQVDENWYEGRIPGTSRQ--GIFPIT----------------YVDVIKRPL- 580
G TL R PG+ R+ G F IT ++ I P+
Sbjct: 280 -GNTSTLRRG----------PGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVL 328
Query: 581 --------VKNPVDYMDLPFSSSPSRSAT--ASPQQPQAQQRRVTPDRSQTSQDLFSYQA 630
+ P++ D+P SS + +T +P P V+ SQ + A
Sbjct: 329 ISSSNPSVITQPMEKADVP-SSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVA 387
Query: 631 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 683
L+SY DEL+L+ G+ V V+ KC DGW G S T + G FP NYV P++
Sbjct: 388 LHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 79.3 bits (194), Expect = 1e-14
Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)
Query: 448 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 508 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 563
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 564 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616
+ GIFPI +V+ ++++ + +L SS SR T++ ++ +R+V
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 617 DRSQTS 622
S T+
Sbjct: 298 QFSITT 303
Score = 36.6 bits (83), Expect = 0.079
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 598 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 657
R + +P++ QA R+ P+ + +AL +Y QN +L GDI+ + + D
Sbjct: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
Query: 658 DGWFVGTSRRTKQFGTFPGNYVK 680
+ W+ G G FP + V+
Sbjct: 160 ENWYQGEINGIS--GNFPASSVE 180
Score = 34.7 bits (78), Expect = 0.30
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)
Query: 523 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 578
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
Query: 579 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
P ++P Y S+S S S+ S + +Q R
Sbjct: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 523 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 581
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
Query: 582 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 627
++ D LP +S R +T A QP Q + + +
Sbjct: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
Query: 628 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 505
R + F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL----- 165
Query: 506 AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 565
+V + GE D++ ++ I L V E G + T +
Sbjct: 166 ---------EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPK 209
Query: 566 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPD 617
I I + D+ K VK L +S S + P++ P+ Q +T
Sbjct: 210 KIRGIGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKT 262
Query: 618 RSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTF 674
++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G F
Sbjct: 263 DTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVF 320
Query: 675 PGNY 678
P N+
Sbjct: 321 PDNF 324
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDD----KEMRPARA 450
GDI +G L+ +SS+ T++ + + I T+ + D K R
Sbjct: 217 GDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRT 276
Query: 451 KFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K P
Sbjct: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
Query: 509 KKLTP 513
K P
Sbjct: 337 KPKKP 341
Score = 36.6 bits (83), Expect = 0.079
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 625 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 682
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,457,236
Number of Sequences: 37866
Number of extensions: 1412573
Number of successful extensions: 6516
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 254
Number of HSP's that attempted gapping in prelim test: 5128
Number of HSP's gapped (non-prelim): 1240
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.