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Search of human proteins with 7705318
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705318 GULP, engulfment adaptor PTB domain containing 1
[Homo sapiens]
(304 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 621 e-178
gi|50511947 cajalin 2 isoform b [Homo sapiens] 95 9e-20
gi|50511945 cajalin 2 isoform a [Homo sapiens] 95 9e-20
gi|10047134 cajalin 2 isoform c [Homo sapiens] 95 9e-20
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 90 2e-18
gi|132626790 low density lipoprotein receptor adaptor protein 1 ... 88 8e-18
gi|54144627 numb homolog isoform 2 [Homo sapiens] 84 2e-16
gi|54144625 numb homolog isoform 1 [Homo sapiens] 84 2e-16
gi|54144629 numb homolog isoform 4 [Homo sapiens] 82 8e-16
gi|20070356 numb homolog isoform 3 [Homo sapiens] 82 8e-16
gi|148491082 disabled homolog 2 [Homo sapiens] 79 4e-15
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens] 78 1e-14
gi|33350928 disabled homolog 1 [Homo sapiens] 77 2e-14
gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein i... 70 2e-12
gi|4885433 mitogen-activated protein kinase 8 interacting protei... 69 5e-12
gi|194239668 SHC (Src homology 2 domain containing) transforming... 61 1e-09
gi|194239662 SHC (Src homology 2 domain containing) transforming... 61 1e-09
gi|169211037 PREDICTED: similar to mitogen-activated protein kin... 61 1e-09
gi|239740950 PREDICTED: similar to mitogen-activated protein kin... 61 1e-09
gi|169790811 SHC (Src homology 2 domain containing) transforming... 60 2e-09
gi|6912242 adaptor protein, phosphotyrosine interaction, PH doma... 60 3e-09
gi|194239664 SHC (Src homology 2 domain containing) transforming... 58 1e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 58 1e-08
gi|22035548 amyloid beta A4 precursor protein-binding, family A,... 57 2e-08
gi|194353992 amyloid beta A4 precursor protein-binding, family A... 55 6e-08
gi|6912492 mitogen-activated protein kinase 8 interacting protei... 55 8e-08
gi|7706537 mitogen-activated protein kinase 8 interacting protei... 55 8e-08
gi|22035550 amyloid beta A4 precursor protein-binding, family A,... 53 3e-07
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 51 1e-06
gi|11342678 amyloid beta (A4) precursor protein-binding, family ... 50 3e-06
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 621 bits (1601), Expect = e-178
Identities = 304/304 (100%), Positives = 304/304 (100%)
Query: 1 MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK 60
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK
Sbjct: 1 MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK 60
Query: 61 KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES 120
KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES
Sbjct: 61 KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES 120
Query: 121 NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN 180
NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN
Sbjct: 121 NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN 180
Query: 181 MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP 240
MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP
Sbjct: 181 MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP 240
Query: 241 PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL 300
PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL
Sbjct: 241 PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL 300
Query: 301 DSRC 304
DSRC
Sbjct: 301 DSRC 304
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 94.7 bits (234), Expect = 9e-20
Identities = 53/156 (33%), Positives = 83/156 (53%), Gaps = 2/156 (1%)
Query: 2 NRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKK 61
N A + + W H PE L Y A +LGS +++ +GTE +DA K++
Sbjct: 287 NEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST 346
Query: 62 SEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESN 121
+ +K+P + L +S GVK ++ K + ++ IS A D D F +I KD +SN
Sbjct: 347 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 406
Query: 122 KHLCYVFDS--EKCAEEITLTIGQAFDLAYRKFLES 155
H C+VF + A EI LT+GQAF++AY+ L++
Sbjct: 407 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQA 442
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 94.7 bits (234), Expect = 9e-20
Identities = 53/156 (33%), Positives = 83/156 (53%), Gaps = 2/156 (1%)
Query: 2 NRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKK 61
N A + + W H PE L Y A +LGS +++ +GTE +DA K++
Sbjct: 1037 NEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST 1096
Query: 62 SEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESN 121
+ +K+P + L +S GVK ++ K + ++ IS A D D F +I KD +SN
Sbjct: 1097 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 1156
Query: 122 KHLCYVFDS--EKCAEEITLTIGQAFDLAYRKFLES 155
H C+VF + A EI LT+GQAF++AY+ L++
Sbjct: 1157 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQA 1192
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 94.7 bits (234), Expect = 9e-20
Identities = 53/156 (33%), Positives = 83/156 (53%), Gaps = 2/156 (1%)
Query: 2 NRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKK 61
N A + + W H PE L Y A +LGS +++ +GTE +DA K++
Sbjct: 203 NEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST 262
Query: 62 SEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESN 121
+ +K+P + L +S GVK ++ K + ++ IS A D D F +I KD +SN
Sbjct: 263 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 322
Query: 122 KHLCYVFDS--EKCAEEITLTIGQAFDLAYRKFLES 155
H C+VF + A EI LT+GQAF++AY+ L++
Sbjct: 323 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQA 358
>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
1 [Homo sapiens]
Length = 1134
Score = 90.1 bits (222), Expect = 2e-18
Identities = 53/148 (35%), Positives = 80/148 (54%), Gaps = 8/148 (5%)
Query: 11 KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKL-KFARHIKKSEGQKIPK 69
++W H PE L Y A +LGS ++ +GTE +DA K+ K H+KK IP
Sbjct: 926 QSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKK-----IPT 980
Query: 70 VELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFD 129
+ L I+ GVK ++ K V ++ IS A D D F +I KD +++ H C+VF
Sbjct: 981 IILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFS 1040
Query: 130 S--EKCAEEITLTIGQAFDLAYRKFLES 155
+ EI LT+GQAF++AY+ L++
Sbjct: 1041 TVDVNLTYEIILTLGQAFEVAYQLALQA 1068
>gi|132626790 low density lipoprotein receptor adaptor protein 1
[Homo sapiens]
Length = 308
Score = 88.2 bits (217), Expect = 8e-18
Identities = 50/159 (31%), Positives = 89/159 (55%), Gaps = 7/159 (4%)
Query: 7 RKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQK 66
RK + W T E L + + ++ K+LG T VEQPKG E+ A++++ K+ G+K
Sbjct: 29 RKLPENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATA---KASGKK 84
Query: 67 IPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCY 126
+ KV L++S G+ + + T ++ N ++RIS+C DK ++F +I + + C+
Sbjct: 85 LQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECH 144
Query: 127 VF--DSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETR 163
F K A+ +TLT+ QAF +A+ +F + ++ E R
Sbjct: 145 AFLCTKRKMAQAVTLTVAQAFKVAF-EFWQVSKEEKEKR 182
>gi|54144627 numb homolog isoform 2 [Homo sapiens]
Length = 603
Score = 83.6 bits (205), Expect = 2e-16
Identities = 63/264 (23%), Positives = 125/264 (47%), Gaps = 31/264 (11%)
Query: 1 MNRAFSRKKD---------KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVR 51
+ ++F RKKD W E + + K+LG EV++ +G + DAV+
Sbjct: 4 LRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVK 63
Query: 52 KLKFARHIKKS----EGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTD 107
+LK R K G+K K L +S G+++++ KTK++ + + ++SFCA D+
Sbjct: 64 RLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNF 123
Query: 108 KRIFTFICKDSESNKHLCYVFDSEK-CAEEITLTIGQAF----DLAYRKFLESG------ 156
R F++IC+D + + +C+ F + K E ++ +G AF + ++ E G
Sbjct: 124 DRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFD 183
Query: 157 -GKDVETRKQIAGLQKRIQDLETENMELKNKVQDLE----NQLRITQVSAPPAGSMTPKS 211
+ TR+ + + E E E+ ++QD + +++ + AP + +P S
Sbjct: 184 ASRTTFTREGSFRVTTATEQAERE--EIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSS 241
Query: 212 PSTDIFDMIPFSPISHQSSMPTRN 235
P++ D +++ ++P R+
Sbjct: 242 PTSPTSDATTSLEMNNPHAIPRRH 265
>gi|54144625 numb homolog isoform 1 [Homo sapiens]
Length = 651
Score = 83.6 bits (205), Expect = 2e-16
Identities = 63/264 (23%), Positives = 125/264 (47%), Gaps = 31/264 (11%)
Query: 1 MNRAFSRKKD---------KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVR 51
+ ++F RKKD W E + + K+LG EV++ +G + DAV+
Sbjct: 4 LRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVK 63
Query: 52 KLKFARHIKKS----EGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTD 107
+LK R K G+K K L +S G+++++ KTK++ + + ++SFCA D+
Sbjct: 64 RLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNF 123
Query: 108 KRIFTFICKDSESNKHLCYVFDSEK-CAEEITLTIGQAF----DLAYRKFLESG------ 156
R F++IC+D + + +C+ F + K E ++ +G AF + ++ E G
Sbjct: 124 DRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFD 183
Query: 157 -GKDVETRKQIAGLQKRIQDLETENMELKNKVQDLE----NQLRITQVSAPPAGSMTPKS 211
+ TR+ + + E E E+ ++QD + +++ + AP + +P S
Sbjct: 184 ASRTTFTREGSFRVTTATEQAERE--EIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSS 241
Query: 212 PSTDIFDMIPFSPISHQSSMPTRN 235
P++ D +++ ++P R+
Sbjct: 242 PTSPTSDATTSLEMNNPHAIPRRH 265
>gi|54144629 numb homolog isoform 4 [Homo sapiens]
Length = 592
Score = 81.6 bits (200), Expect = 8e-16
Identities = 61/260 (23%), Positives = 124/260 (47%), Gaps = 34/260 (13%)
Query: 1 MNRAFSRKKD---------KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVR 51
+ ++F RKKD W E + + K+LG EV++ +G + DAV+
Sbjct: 4 LRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVK 63
Query: 52 KLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIF 111
+LK + G+K K L +S G+++++ KTK++ + + ++SFCA D+ R F
Sbjct: 64 RLK-------ATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAF 116
Query: 112 TFICKDSESNKHLCYVFDSEK-CAEEITLTIGQAF----DLAYRKFLESG-------GKD 159
++IC+D + + +C+ F + K E ++ +G AF + ++ E G +
Sbjct: 117 SYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRT 176
Query: 160 VETRKQIAGLQKRIQDLETENMELKNKVQDLE----NQLRITQVSAPPAGSMTPKSPSTD 215
TR+ + + E E E+ ++QD + +++ + AP + +P SP++
Sbjct: 177 TFTREGSFRVTTATEQAERE--EIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSP 234
Query: 216 IFDMIPFSPISHQSSMPTRN 235
D +++ ++P R+
Sbjct: 235 TSDATTSLEMNNPHAIPRRH 254
>gi|20070356 numb homolog isoform 3 [Homo sapiens]
Length = 640
Score = 81.6 bits (200), Expect = 8e-16
Identities = 61/260 (23%), Positives = 124/260 (47%), Gaps = 34/260 (13%)
Query: 1 MNRAFSRKKD---------KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVR 51
+ ++F RKKD W E + + K+LG EV++ +G + DAV+
Sbjct: 4 LRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVK 63
Query: 52 KLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIF 111
+LK + G+K K L +S G+++++ KTK++ + + ++SFCA D+ R F
Sbjct: 64 RLK-------ATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAF 116
Query: 112 TFICKDSESNKHLCYVFDSEK-CAEEITLTIGQAF----DLAYRKFLESG-------GKD 159
++IC+D + + +C+ F + K E ++ +G AF + ++ E G +
Sbjct: 117 SYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRT 176
Query: 160 VETRKQIAGLQKRIQDLETENMELKNKVQDLE----NQLRITQVSAPPAGSMTPKSPSTD 215
TR+ + + E E E+ ++QD + +++ + AP + +P SP++
Sbjct: 177 TFTREGSFRVTTATEQAERE--EIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSP 234
Query: 216 IFDMIPFSPISHQSSMPTRN 235
D +++ ++P R+
Sbjct: 235 TSDATTSLEMNNPHAIPRRH 254
>gi|148491082 disabled homolog 2 [Homo sapiens]
Length = 770
Score = 79.3 bits (194), Expect = 4e-15
Identities = 54/203 (26%), Positives = 100/203 (49%), Gaps = 11/203 (5%)
Query: 7 RKKDKTWMHTPEALSKHF----IPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKS 62
++K K T E L F + Y AK +G +V +G ++ +D++ KLK +S
Sbjct: 26 KEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRS 85
Query: 63 EGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNK 122
+GQ ++ + IS+ G+KI++ KT ++H +++ISF A D TD R F ++C +
Sbjct: 86 QGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVC--GGEGQ 143
Query: 123 HLCYVFDSEKCAEEITLTIGQAFDLAY--RKFLESGGKDVETRKQIAGLQKRIQDLETEN 180
H + + + AE + + + F + Y +K E K E K + + + L+ +
Sbjct: 144 HQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQT 203
Query: 181 MELKNKVQDLENQLRITQVSAPP 203
+LK+ V ++ +S PP
Sbjct: 204 NKLKSGVDQMD---LFGDMSTPP 223
>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
Length = 609
Score = 77.8 bits (190), Expect = 1e-14
Identities = 41/134 (30%), Positives = 76/134 (56%), Gaps = 8/134 (5%)
Query: 13 WMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVEL 72
W +A+ K + ++LG EVE+ +G V DAV+KLK + G+K K L
Sbjct: 66 WQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLK-------AMGRKSVKSVL 118
Query: 73 QISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEK 132
+S G+++++ KTK++ + + ++SFCA D+ + F++IC+D + + +C+ F + K
Sbjct: 119 WVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALK 178
Query: 133 -CAEEITLTIGQAF 145
E ++ +G AF
Sbjct: 179 DSGERLSHAVGCAF 192
>gi|33350928 disabled homolog 1 [Homo sapiens]
Length = 555
Score = 77.0 bits (188), Expect = 2e-14
Identities = 71/277 (25%), Positives = 119/277 (42%), Gaps = 27/277 (9%)
Query: 6 SRKKDKTWMHTPEALSKHF----IPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKK 61
SRKK + + L K F + Y AK +G EV +G ++ +D++ KLK +
Sbjct: 19 SRKKGQD--RSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGAR 76
Query: 62 SEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESN 121
S+G+ K+ L IS G+KI + KT +QH+ +H IS+ A D TD R F ++C +
Sbjct: 77 SKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVC--GKEG 134
Query: 122 KHLCYVFDSEKCAEEITLTIGQAFDLAY----RKFLE-SGGKDVETRKQI--AGLQKRIQ 174
H + + AE + L + F L Y R+ LE KD + + + L++ ++
Sbjct: 135 NHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVE 194
Query: 175 DLETENMELK---NKVQDLENQLRITQVSAP---------PAGSMTPKSPSTDIFDMIPF 222
D + + + ++D E + I QV P ++F +
Sbjct: 195 DPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMST 254
Query: 223 SPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPF 259
P P G P S++ D+F + PF
Sbjct: 255 PPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPF 291
>gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein
isoform 1 [Homo sapiens]
Length = 506
Score = 70.5 bits (171), Expect = 2e-12
Identities = 70/274 (25%), Positives = 127/274 (46%), Gaps = 54/274 (19%)
Query: 14 MHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKF---ARHIKKSEGQKIPKV 70
+H +A +H I + AK++GS +V +P + A+R++++ A++IKK KV
Sbjct: 20 LHNEDAF-QHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKK------KV 72
Query: 71 ELQISIYGVKILEPKTKEVQ----------------HNCQLHRISFCADDKTDKRIFTFI 114
+ +S+ GVK++ K K++ ++RI + + D D +IF++I
Sbjct: 73 SIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYI 132
Query: 115 CKDSESNKHLCYVFDSEKCAE--EITLTIGQAFDLAYRKFLE------SGGKDVETR--- 163
+D SN C VF S+K ++ I T+GQAF++ ++ L+ G +D E+
Sbjct: 133 ARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNS 192
Query: 164 -------KQIAGLQK----RIQDLETENMELKNKVQD-LENQLRITQVSA--PPAGSMTP 209
+Q+ G ++ ++ + + +E+ D LE +T + A GS T
Sbjct: 193 NSSGDPGRQLTGAERASTATAEETDIDAVEVPLPGNDVLEFSRGVTDLDAVGKEGGSHTG 252
Query: 210 KSPSTDIFDMIPFSP---ISHQSSMPTRNGTQPP 240
S M+ SP + SS P GT+ P
Sbjct: 253 SKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETP 286
>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
[Homo sapiens]
Length = 711
Score = 68.9 bits (167), Expect = 5e-12
Identities = 44/135 (32%), Positives = 68/135 (50%), Gaps = 8/135 (5%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81
+ KFLGS +V KG +V+ A++K+ R + V L+IS+ GVKI
Sbjct: 567 FRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGVKAD 625
Query: 82 --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139
E K + H QL ISFC + + F FI K ++ C+VF SE + +
Sbjct: 626 DSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAE 685
Query: 140 TIGQAFDLAYRKFLE 154
++G+AF Y++F+E
Sbjct: 686 SVGRAFQQFYKQFVE 700
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 61.2 bits (147), Expect = 1e-09
Identities = 69/342 (20%), Positives = 124/342 (36%), Gaps = 74/342 (21%)
Query: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50
+F K + W+H + + + Y +++G EV Q T+V R+A+
Sbjct: 29 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 88
Query: 51 ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96
R+ +R + G+ K + L +S + ++ K++ N +
Sbjct: 89 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 148
Query: 97 RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155
ISF + D + N+ C++ + E A+++ TIGQAF+L ++++L +
Sbjct: 149 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 208
Query: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206
K V ++AG D E E D + +R+ + +AP A
Sbjct: 209 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 268
Query: 207 MT---------------------------------PKSPSTDIFDMIPFSPISHQSSMPT 233
T P P ++FD + + +
Sbjct: 269 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQ 328
Query: 234 RNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275
G PP P+ + RDLF +PF+ A PP QS
Sbjct: 329 AVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 366
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 61.2 bits (147), Expect = 1e-09
Identities = 69/342 (20%), Positives = 124/342 (36%), Gaps = 74/342 (21%)
Query: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50
+F K + W+H + + + Y +++G EV Q T+V R+A+
Sbjct: 139 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 198
Query: 51 ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96
R+ +R + G+ K + L +S + ++ K++ N +
Sbjct: 199 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 258
Query: 97 RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155
ISF + D + N+ C++ + E A+++ TIGQAF+L ++++L +
Sbjct: 259 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 318
Query: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206
K V ++AG D E E D + +R+ + +AP A
Sbjct: 319 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 378
Query: 207 MT---------------------------------PKSPSTDIFDMIPFSPISHQSSMPT 233
T P P ++FD + + +
Sbjct: 379 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQ 438
Query: 234 RNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275
G PP P+ + RDLF +PF+ A PP QS
Sbjct: 439 AVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 476
>gi|169211037 PREDICTED: similar to mitogen-activated protein kinase
8 interacting protein 1 [Homo sapiens]
Length = 423
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81
+ KFLGS +V KG V+ A++K+ R + V L+IS+ GVKI
Sbjct: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGIKAD 337
Query: 82 --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139
E K + H QL ISF + + F FI K ++ C+VF SE + +
Sbjct: 338 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAE 397
Query: 140 TIGQAFDLAYRKFLE 154
++G+AF +++F+E
Sbjct: 398 SVGRAFQQFHKQFVE 412
>gi|239740950 PREDICTED: similar to mitogen-activated protein kinase
8 interacting protein 1 [Homo sapiens]
Length = 442
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81
+ KFLGS +V KG V+ A++K+ R + V L+IS+ GVKI
Sbjct: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGVKAD 356
Query: 82 --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139
E K + H QL ISF + + F FI K ++ C+VF SE + +
Sbjct: 357 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAE 416
Query: 140 TIGQAFDLAYRKFLE 154
++G+AF +++F+E
Sbjct: 417 SVGRAFQQFHKQFVE 431
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 60.1 bits (144), Expect = 2e-09
Identities = 70/313 (22%), Positives = 125/313 (39%), Gaps = 58/313 (18%)
Query: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAVRKLKFA 56
+F K W+H + + Y +++G EV + T+V R+A+ +L A
Sbjct: 130 SFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEA 189
Query: 57 -RHIKKSEGQKIPK------------------VELQISIYGVKILEPKTKEVQHNCQLHR 97
++ S +K P + + IS G+ + P T++V N +
Sbjct: 190 VPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPS 249
Query: 98 ISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLESG 156
ISF + TD + N+ C++ + E A+ I T+GQAF+L ++++L S
Sbjct: 250 ISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSP 309
Query: 157 GKDVETRKQIAGLQKRIQDLETENME------LKNKVQDL----ENQLRITQVSAPPAGS 206
K +++AG ++ E +++E + K L +++L +TQ A A
Sbjct: 310 PKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALD 369
Query: 207 MTPKSPSTDIFDMIPFSPISHQSSMPTRNG-------------------TQPPPVPSRST 247
P SPS +P+ + + P +G TQ P
Sbjct: 370 QGP-SPSLRDACSLPWD-VGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPED 427
Query: 248 EIKRDLFGAEPFD 260
K+DLF PF+
Sbjct: 428 SPKKDLFDMRPFE 440
>gi|6912242 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 1 [Homo sapiens]
Length = 709
Score = 59.7 bits (143), Expect = 3e-09
Identities = 47/180 (26%), Positives = 96/180 (53%), Gaps = 14/180 (7%)
Query: 30 KFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEV 89
+FLGS EV+ +VV + +R++ AR I ++ + L ++ +K+++P+T+
Sbjct: 505 RFLGSMEVKSDDHPDVVYETMRQILAARAIHNIF--RMTESHLLVTCDCLKLIDPQTQVT 562
Query: 90 QHNCQLHRISFCADDKTDKRIFTFICKD----SESN-KHLCYVFDSEKCAEEITLTIGQA 144
+ L + A + +KR+F F+ + SESN +CY+F+S E+I ++G A
Sbjct: 563 RLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLA 622
Query: 145 FDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQ-DLENQLRITQVSAPP 203
+A L+ + E +K+I +R+++ + + + + +++ DLE Q R+ S+ P
Sbjct: 623 KQIALHAELDR--RASEKQKEI----ERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRP 676
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 57.8 bits (138), Expect = 1e-08
Identities = 68/343 (19%), Positives = 124/343 (36%), Gaps = 75/343 (21%)
Query: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50
+F K + W+H + + + Y +++G EV Q T+V R+A+
Sbjct: 139 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 198
Query: 51 ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96
R+ +R + G+ K + L +S + ++ K++ N +
Sbjct: 199 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 258
Query: 97 RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155
ISF + D + N+ C++ + E A+++ TIGQAF+L ++++L +
Sbjct: 259 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 318
Query: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206
K V ++AG D E E D + +R+ + +AP A
Sbjct: 319 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 378
Query: 207 MTPKSPST----------------------------------DIFDMIPFSPISHQSSMP 232
T + T ++FD + + +
Sbjct: 379 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKAR 438
Query: 233 TRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275
G PP P+ + RDLF +PF+ A PP QS
Sbjct: 439 QAVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 477
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 57.8 bits (138), Expect = 1e-08
Identities = 68/343 (19%), Positives = 124/343 (36%), Gaps = 75/343 (21%)
Query: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50
+F K + W+H + + + Y +++G EV Q T+V R+A+
Sbjct: 29 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 88
Query: 51 ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96
R+ +R + G+ K + L +S + ++ K++ N +
Sbjct: 89 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 148
Query: 97 RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155
ISF + D + N+ C++ + E A+++ TIGQAF+L ++++L +
Sbjct: 149 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 208
Query: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206
K V ++AG D E E D + +R+ + +AP A
Sbjct: 209 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 268
Query: 207 MTPKSPST----------------------------------DIFDMIPFSPISHQSSMP 232
T + T ++FD + + +
Sbjct: 269 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKAR 328
Query: 233 TRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275
G PP P+ + RDLF +PF+ A PP QS
Sbjct: 329 QAVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 367
>gi|22035548 amyloid beta A4 precursor protein-binding, family A,
member 1 [Homo sapiens]
Length = 837
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/171 (28%), Positives = 82/171 (47%), Gaps = 31/171 (18%)
Query: 25 IPYNAKFLGSTEVEQPKGTEV------VRDAVRKLKFARHIKKS-------EGQKIPKVE 71
I + A +LGST++ K ++AV ++K A+ + KS E Q + +V+
Sbjct: 459 IIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVD 518
Query: 72 LQISIYGVKILEPKTKEVQHNCQLHRISFCAD-------------DKTDKRIFTFICKDS 118
L IS +K+L T+E + L IS+ AD +++ + S
Sbjct: 519 LFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPS 578
Query: 119 ESNKH----LCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQ 165
+ K +C+VF+SE A+ I +IGQAF +AY++FL + G + E Q
Sbjct: 579 QDGKRQYKMICHVFESED-AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ 628
>gi|194353992 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform b [Homo sapiens]
Length = 737
Score = 55.5 bits (132), Expect = 6e-08
Identities = 46/160 (28%), Positives = 77/160 (48%), Gaps = 20/160 (12%)
Query: 25 IPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEG--QKIPKVELQISIYGVKIL 82
I + A +LGST++ + ++ + +K SEG Q + +V+L IS +K+L
Sbjct: 370 IIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKNSEGDAQTLTEVDLFISTQRIKVL 429
Query: 83 EPKTKEVQHNCQLHRISFCADD------KTDKRIFTFICKD-----------SESNKHLC 125
T+E + L IS+ AD +R+ +D + K +C
Sbjct: 430 NADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMIC 489
Query: 126 YVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQ 165
+VF+SE A+ I +IGQAF +AY++FL + G + E Q
Sbjct: 490 HVFESED-AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ 528
>gi|6912492 mitogen-activated protein kinase 8 interacting protein 2
isoform 1 [Homo sapiens]
Length = 824
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/132 (29%), Positives = 69/132 (52%), Gaps = 7/132 (5%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIP-KVELQISIYGVKIL--- 82
++ +FLGS EV +G ++ A++K+ AR K + + P +L+IS+ GVK+
Sbjct: 683 FDVQFLGSVEVPCHQGNGILCAAMQKIATAR--KLTVHLRPPASCDLEISLRGVKLSLSG 740
Query: 83 -EPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTI 141
P+ + H Q+ ISFC + F FI K ++ C+VF S++ + ++
Sbjct: 741 GGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVAQSV 800
Query: 142 GQAFDLAYRKFL 153
G+AF Y++ L
Sbjct: 801 GRAFLEYYQEHL 812
>gi|7706537 mitogen-activated protein kinase 8 interacting protein 2
isoform 2 [Homo sapiens]
Length = 797
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/132 (29%), Positives = 69/132 (52%), Gaps = 7/132 (5%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIP-KVELQISIYGVKIL--- 82
++ +FLGS EV +G ++ A++K+ AR K + + P +L+IS+ GVK+
Sbjct: 656 FDVQFLGSVEVPCHQGNGILCAAMQKIATAR--KLTVHLRPPASCDLEISLRGVKLSLSG 713
Query: 83 -EPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTI 141
P+ + H Q+ ISFC + F FI K ++ C+VF S++ + ++
Sbjct: 714 GGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVAQSV 773
Query: 142 GQAFDLAYRKFL 153
G+AF Y++ L
Sbjct: 774 GRAFLEYYQEHL 785
>gi|22035550 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform a [Homo sapiens]
Length = 749
Score = 53.1 bits (126), Expect = 3e-07
Identities = 52/172 (30%), Positives = 80/172 (46%), Gaps = 32/172 (18%)
Query: 25 IPYNAKFLGSTE----------VEQPKGTEVVRDAVRKLKFARHIKK--SEG--QKIPKV 70
I + A +LGST+ + + E V R K A+ KK SEG Q + +V
Sbjct: 370 IIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEV 429
Query: 71 ELQISIYGVKILEPKTKEVQHNCQLHRISFCADD------KTDKRIFTFICKD------- 117
+L IS +K+L T+E + L IS+ AD +R+ +D
Sbjct: 430 DLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPG 489
Query: 118 ----SESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQ 165
+ K +C+VF+SE A+ I +IGQAF +AY++FL + G + E Q
Sbjct: 490 AQEGKKQYKMICHVFESED-AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ 540
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 51.2 bits (121), Expect = 1e-06
Identities = 31/113 (27%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 41 KGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISF 100
+G++ + R H++ S+ +K + Q+ + + ++ P TK V IS
Sbjct: 328 EGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISS 387
Query: 101 CADDKTDKRIFTFICKDSES---NKHLCYVFD--SEKCAEEITLTIGQAFDLA 148
C+ F FIC++S ++++CYVF SE +E+ LT+ QAF A
Sbjct: 388 CSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTA 440
>gi|11342678 amyloid beta (A4) precursor protein-binding, family A,
member 3 [Homo sapiens]
Length = 575
Score = 49.7 bits (117), Expect = 3e-06
Identities = 40/144 (27%), Positives = 66/144 (45%), Gaps = 12/144 (8%)
Query: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIP--KVELQISIYGVKILEP 84
+ A++LGST++ + + + +K +G+ P +V+L +S +K+L
Sbjct: 221 FGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTA 280
Query: 85 KTKEVQHNCQLHRISFCADD------KTDKRIFTFICKDSESN---KHLCYVFDSEKCAE 135
++E + LH IS+ AD +R+ K LC+VF +E A+
Sbjct: 281 DSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAED-AQ 339
Query: 136 EITLTIGQAFDLAYRKFLESGGKD 159
I IGQAF AY +FL G D
Sbjct: 340 LIAQAIGQAFAAAYSQFLRESGID 363
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,428,022
Number of Sequences: 37866
Number of extensions: 606592
Number of successful extensions: 3547
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 3262
Number of HSP's gapped (non-prelim): 341
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.