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Search of human proteins with 7662436
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662436 DAZ interacting protein 1 isoform 1 [Homo sapiens]
(848 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662436 DAZ interacting protein 1 isoform 1 [Homo sapiens] 1690 0.0
gi|39725957 DAZ interacting protein 1 isoform 2 [Homo sapiens] 1677 0.0
gi|27734911 DAZ interacting protein 1-like [Homo sapiens] 337 2e-92
gi|21735548 centrosomal protein 2 [Homo sapiens] 64 5e-10
gi|38044112 restin isoform b [Homo sapiens] 64 5e-10
gi|4506751 restin isoform a [Homo sapiens] 64 5e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 63 1e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 63 1e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 62 2e-09
gi|71061468 centromere protein E [Homo sapiens] 62 3e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 62 3e-09
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 62 3e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 61 4e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 61 5e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 61 5e-09
gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens] 60 7e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 60 7e-09
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 59 1e-08
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap... 59 1e-08
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap... 59 1e-08
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap... 59 1e-08
gi|148746195 trichohyalin [Homo sapiens] 59 1e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 59 2e-08
gi|58530840 desmoplakin isoform I [Homo sapiens] 59 2e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 59 2e-08
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 58 3e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 57 6e-08
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 57 6e-08
gi|30794488 kinesin family member 27 [Homo sapiens] 57 6e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 57 9e-08
>gi|7662436 DAZ interacting protein 1 isoform 1 [Homo sapiens]
Length = 848
Score = 1690 bits (4376), Expect = 0.0
Identities = 848/848 (100%), Positives = 848/848 (100%)
Query: 1 MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF 60
MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF
Sbjct: 1 MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF 60
Query: 61 RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL 120
RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL
Sbjct: 61 RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL 120
Query: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR 180
IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR
Sbjct: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR 180
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR
Sbjct: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
Query: 241 SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE 300
SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE
Sbjct: 241 SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE 300
Query: 301 MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF 360
MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF
Sbjct: 301 MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF 360
Query: 361 HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 420
HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE
Sbjct: 361 HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 420
Query: 421 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSH 480
LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSH
Sbjct: 421 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSH 480
Query: 481 ILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGIN 540
ILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGIN
Sbjct: 481 ILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGIN 540
Query: 541 ADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSV 600
ADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSV
Sbjct: 541 ADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSV 600
Query: 601 SQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPP 660
SQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPP
Sbjct: 601 SQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPP 660
Query: 661 FSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPA 720
FSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPA
Sbjct: 661 FSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPA 720
Query: 721 GVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQELKCADVEDEDWDISSLEE 780
GVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQELKCADVEDEDWDISSLEE
Sbjct: 721 GVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQELKCADVEDEDWDISSLEE 780
Query: 781 EISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKGEGLQENESSTLKSSLVTVT 840
EISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKGEGLQENESSTLKSSLVTVT
Sbjct: 781 EISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKGEGLQENESSTLKSSLVTVT 840
Query: 841 DWSDTSDV 848
DWSDTSDV
Sbjct: 841 DWSDTSDV 848
>gi|39725957 DAZ interacting protein 1 isoform 2 [Homo sapiens]
Length = 867
Score = 1677 bits (4343), Expect = 0.0
Identities = 847/867 (97%), Positives = 848/867 (97%), Gaps = 19/867 (2%)
Query: 1 MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF 60
MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF
Sbjct: 1 MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF 60
Query: 61 RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL 120
RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL
Sbjct: 61 RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL 120
Query: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR 180
IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR
Sbjct: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR 180
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR
Sbjct: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
Query: 241 SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE 300
SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE
Sbjct: 241 SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE 300
Query: 301 MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF 360
MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF
Sbjct: 301 MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF 360
Query: 361 HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 420
HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE
Sbjct: 361 HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE 420
Query: 421 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPK-------------------VNAPALH 461
LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPK +NAPALH
Sbjct: 421 LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGNPLAWQAFESQPAAPAVPMNAPALH 480
Query: 462 TLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKG 521
TLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKG
Sbjct: 481 TLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKG 540
Query: 522 LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEH 581
LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEH
Sbjct: 541 LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEH 600
Query: 582 QVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIK 641
QVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIK
Sbjct: 601 QVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIK 660
Query: 642 KNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSD 701
KNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSD
Sbjct: 661 KNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSD 720
Query: 702 ADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQ 761
ADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQ
Sbjct: 721 ADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQ 780
Query: 762 ELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG 821
ELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG
Sbjct: 781 ELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG 840
Query: 822 EGLQENESSTLKSSLVTVTDWSDTSDV 848
EGLQENESSTLKSSLVTVTDWSDTSDV
Sbjct: 841 EGLQENESSTLKSSLVTVTDWSDTSDV 867
>gi|27734911 DAZ interacting protein 1-like [Homo sapiens]
Length = 767
Score = 337 bits (865), Expect = 2e-92
Identities = 256/774 (33%), Positives = 395/774 (51%), Gaps = 89/774 (11%)
Query: 46 APPSAASGPL------PFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFC 99
A SGPL P F+F+PR +S+DWRR+S +DVD+VA +DV TLQENI ITFC
Sbjct: 6 ATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFC 65
Query: 100 KLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQS 159
L+ E C C VDP LLK++RLAQ IEYLLH Q+ L++ + LE RL+ S ++
Sbjct: 66 NLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRG 125
Query: 160 KKLLTKQAGEIKTLKEECKRRKKMIST-QQLMIEAKA-NYYQCHFCDKAFMNQAFLQSHI 217
++ L +QA E+K ++EE +RR+KMIST QQL+++ +Y+ CH CDK FMN FL+ HI
Sbjct: 126 QQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHI 185
Query: 218 QRRHTEENSHFEYQKNAQ-IEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQK 276
QRRH + +K Q +E++ E L+ +L+ T+ ELEA A R +E E+
Sbjct: 186 QRRHAGVAEGGKQKKQEQPVEEVLEE---LRAKLKWTQGELEAQREAERQRQLQEAELIH 242
Query: 277 TKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQI 336
+E + K FD+WKE+E KL E++K+K++F EFK + +NS LE +L +Q S+ +
Sbjct: 243 QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ-SHSVM 301
Query: 337 KSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHI 396
+S +G+L+D E E+ ++ + + + Q+++W +V+ +H+EH EK L
Sbjct: 302 ESKLGSLRD--EESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
Query: 397 EKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISE-PKV 455
++L+ S+ D + + +I L +LQEQ +I +Q + I+ + + I + PK
Sbjct: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKA 419
Query: 456 NAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMH-LRKALKS 514
+ EE E E + + ++ H + AL+
Sbjct: 420 --------------------------------VDTEEDSPEEEMEDSQDEQHKVLAALRR 447
Query: 515 NSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQ 574
N +L K R ++E L EKLE++GI D +GIS L + + +R ++ R+ F
Sbjct: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLS 507
Query: 575 IREFLEHQVSCKIEEK-----ALLSSD-QCSV-SQMDTLSTGEV-PK----MIQLPS--- 619
+R L +V+ + +E+ A+ D Q SV SQ L T E PK + LPS
Sbjct: 508 LRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTPA 567
Query: 620 ----KNRQLIRQKAVSTDRTSVPKIKKNV--MEDPFPRKSSTITTPPFSSEEEQEDDDLI 673
RQ S + S P + P ++TPPFSSEE+ E D +
Sbjct: 568 EPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQ 627
Query: 674 RAYASPGPLP---VPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGVAVKTPTEK 730
R P +P VP P++ D TE SE E+ + +G V++ +
Sbjct: 628 RVSLQPPKVPSRMVPRPKDDW---------DWSDTETSE-ENAQPPGQGSGTLVQSMVKN 677
Query: 731 VEKMFPHRKNVNKPVGGTN---VPEMFIKKEELQELKCADVEDE-DWDISSLEE 780
+EK KP GG + +P ++ K EDE D +ISSLE+
Sbjct: 678 LEKQL--EAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDESDLEISSLED 729
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 64.3 bits (155), Expect = 5e-10
Identities = 129/604 (21%), Positives = 240/604 (39%), Gaps = 91/604 (15%)
Query: 119 KLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 178
+L+R Q + L E ++L + E L+ D L A ++ L E
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD-------LRAAAVKLSALNEALA 609
Query: 179 RRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHI----QRRHT--EENSHFEYQ- 231
K ++ Q L +E + N C + A + LQ + +RR E+N+H E Q
Sbjct: 610 LDKVGLNQQLLQLEEE-NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 232 -----KNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLF 286
A+++ +I KEE+Q SE A+ + + ++ K +EE +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 287 DRWKEEEKEKLVDE----------MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNM-- 334
+EKE LV E +E+ ++ ++ + L+S LE L E Q+ N
Sbjct: 729 -----QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 335 -----QIKSNIGTLKDAHEFKE------------DRSPYPQDFHNVMQLLDSQESKWTAR 377
Q++ I T+ A E + +RS Q+ + L E +
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 378 VQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQN---ELIIT 434
++ H+KE +L EK R+ +L + ++ EL RL+EQ E I
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 435 QRQQIKDFTCNPL--NSISEPKVNAPALHT-LETKSSLPMVHEQAFSSHILEPIEELSEE 491
QR++ + + L + K L T L+T+ L +Q +++L E+
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Query: 492 EKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRG--ISSD 549
E + +L + L++A + + L+ L +K++ D++ ++ D
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
Query: 550 QLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTG 609
R+ VE E ++ RE +++I++ LE EKA L TLS
Sbjct: 1024 DSQRL---VEQEVQEKLRETQEYNRIQKELE-------REKASL-----------TLSLM 1062
Query: 610 EVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQED 669
E + R L+ Q+A S + + +++++ E +K + E ++++
Sbjct: 1063 E--------KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
Query: 670 DDLI 673
D +
Sbjct: 1115 ADFL 1118
Score = 43.1 bits (100), Expect = 0.001
Identities = 92/491 (18%), Positives = 194/491 (39%), Gaps = 81/491 (16%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKR-------R 180
IE L +E LT L ++ L L E+ + L ++ + K L+E+ ++ R
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQK---ERIQVLEDQRTRQTKILEEDLEQIKLSLRER 1695
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
+ ++TQ+ +++ +A + S QR E K ++E +
Sbjct: 1696 GRELTTQRQLMQERAE-------------EGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742
Query: 241 SEIVVLKEELQLTRSELEAAHH----ASAVRFSKEYE-------MQKTKEEDFLKLFDRW 289
I L+E +L+ H S + +E E +Q+ +E+ LK
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK----- 1797
Query: 290 KEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEF 349
E+ + +DE ++ +E + L + + Q +++ ++ G L+ AH
Sbjct: 1798 -EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ---GALEQAHMT 1853
Query: 350 KEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNA 409
++R QD + L+ + + RVQA+ + ++ DL A
Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEE-------------------VLGDLRA 1894
Query: 410 SNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSL 469
+ +K + L Q+ EQ + + + ++D + L + + K L L +S
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQD---SWLQAQAVLKERDQELEALRAESQS 1951
Query: 470 PMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQN 529
E+A + E L + + +++ + L ++L+++++ + + +
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 530 LMEKLETLGI------NADIRGISS-DQLHRVLKSVESE-RHKQEREIPNFHQIREFLEH 581
+ E L I + D+R QL + L + E RH+QERE + LE
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE--------QLLEK 2063
Query: 582 QVSCKIEEKAL 592
++ +++E +
Sbjct: 2064 SLAQRVQENMI 2074
Score = 42.7 bits (99), Expect = 0.001
Identities = 117/626 (18%), Positives = 231/626 (36%), Gaps = 79/626 (12%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
+E L Q+ Q ++E+ EQ+ L ++ GE++ KE+ +R ++ ++ +
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878
Query: 188 QLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLK 247
++A + +A L +Q++ E+ E + A + VLK
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLA--LQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 248 E---ELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEE---EKEKLVDEM 301
E EL+ R+E +++ H ++ +Q+ + L + KE+ E+ +L +
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL--QGKEQHLLEQAELSRSL 1994
Query: 302 EKVKEMFMKEFKELTSKN----SALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYP 357
E + + AL Q EIQ +++ + ++ L+ A +++ +
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 358 QDFHNVMQ--LLDSQESKWTARVQAIHQEHKKEKGRLLSH----------------IEKL 399
Q+ +++ L + Q + QE ++E+ R L +E
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
Query: 400 RTSMIDDLNASNVFYKK--------RIEELGQRLQEQNELI-----------ITQRQQIK 440
T ++L A +K +++ L RLQ + E + I R++ +
Sbjct: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQ 2174
Query: 441 DFTCNPLNSISEPKVNAPALH---------TLETKSSLPMVHEQ------AFSSHILEPI 485
D S+++ K + +L LE S + ++ A L
Sbjct: 2175 DLAL----SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSP 2230
Query: 486 EELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRG 545
S E G EQ + ++ +A S + K ++L + + L I+
Sbjct: 2231 GATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQ 2290
Query: 546 ISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDT 605
+ QL L+ VE ER K +RE Q ++S K + D D
Sbjct: 2291 RHNVQLRSTLEQVERERRKLKREAMRAAQAGSL---EIS-KATASSPTQQDGRGQKNSDA 2346
Query: 606 LSTGEVPKMIQLPSKNRQLIR-QKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSE 664
E+ K + L L R QK R++ + + + P ++
Sbjct: 2347 KCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV 2406
Query: 665 EEQE----DDDLIRAYASPGPLPVPP 686
E E D+ L ++ SPGP+ + P
Sbjct: 2407 LEAETRRLDESLTQSLTSPGPVLLHP 2432
Score = 38.9 bits (89), Expect = 0.020
Identities = 106/519 (20%), Positives = 203/519 (39%), Gaps = 75/519 (14%)
Query: 134 SQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEA 193
+++ L Q+ LEERL D E K ++ T ++ +R+ ++ E
Sbjct: 1258 TRDVLRDQVQKLEERLT----DTEAEKS-------QVHTELQDLQRQLSQNQEEKSKWEG 1306
Query: 194 KANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLT 253
K N + + A LQS ++R E E Q ++ + E + + E L
Sbjct: 1307 KQNSLESELME-LHETMASLQSRLRRA---ELQRMEAQGERELLQAAKENLTAQVE-HLQ 1361
Query: 254 RSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFK 313
+ +EA ASA +E +++ + LKL + E E+E+ +++ E+ + + K
Sbjct: 1362 AAVVEARAQASAAGILEE-DLRTARSA--LKLKNEEVESERER-AQALQEQGELKVAQGK 1417
Query: 314 ELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESK 373
L + L L+E ++ ++ I L+ E ++ ++LL K
Sbjct: 1418 ALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKA----------ALELLSLDLKK 1467
Query: 374 WTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELII 433
V + QE +E +EK R+ + E L +QE+ + +
Sbjct: 1468 RNQEVD-LQQEQIQE-------LEKCRSVL---------------EHLPMAVQEREQKLT 1504
Query: 434 TQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILE----PIEELS 489
QR+QI++ L E + N LE + M+ Q L+ +E L+
Sbjct: 1505 VQREQIRE-----LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLA 1559
Query: 490 EEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETL-GINADIRGISS 548
E + EN K+ + L K L+ + T + +L E+ + L ++ I + S
Sbjct: 1560 LELE--ENHHKM-ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 549 DQ--LHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSV------ 600
L R L+ + E Q +I + +E L + + +++ +L ++ V
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE-RRDQELMLQKERIQVLEDQRT 1675
Query: 601 SQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPK 639
Q L + L + R+L Q+ + +R K
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 64.3 bits (155), Expect = 5e-10
Identities = 105/483 (21%), Positives = 191/483 (39%), Gaps = 60/483 (12%)
Query: 139 TSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYY 198
TSQL EE+L D + +K ++ E+K L+++ + +K I + L IE A
Sbjct: 717 TSQLKATEEKL----LDLDALRKASSEGKSEMKKLRQQLEAAEKQI--KHLEIEKNAESS 770
Query: 199 QCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELE 258
+ + + +++Q +E + E L E+ +LKE+ E
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQ--------VKETLEKELQILKEKFA------E 816
Query: 259 AAHHASAVRFSKEYEMQKT--KEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELT 316
A+ A +V+ S + + K KEE F + E+ +E L D K +E +E ++L
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQF-NMLSSDLEKLRENLADMEAKFREKDERE-EQLI 874
Query: 317 SKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKE--------------DRSPYPQDFHN 362
LE ++EI K + S + + D KE + + + Q
Sbjct: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 934
Query: 363 VMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELG 422
M + Q + A+ H+E KKE R LS +EK + + Y++ E
Sbjct: 935 DMTVKAEQSQQEAAKK---HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK 991
Query: 423 QR----LQEQNELIITQRQQIK---DFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQ 475
+ LQ + ++ ++K + L + E + A +T + EQ
Sbjct: 992 TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQ 1051
Query: 476 AFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRK-ALKSNSSLTKGLRTMVEQNLMEKL 534
E E L+ E ++ KL N L++ LK+ L K + +N +K+
Sbjct: 1052 MTK----EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN--QKM 1105
Query: 535 ETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLS 594
E + ++ Q + L +++ E K E+ E HQ K+EE+ +
Sbjct: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD--EVTSHQ---KLEEERSVL 1160
Query: 595 SDQ 597
++Q
Sbjct: 1161 NNQ 1163
Score = 62.8 bits (151), Expect = 1e-09
Identities = 112/545 (20%), Positives = 232/545 (42%), Gaps = 72/545 (13%)
Query: 118 LKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEEC 177
LKL L Q + + +E L +L L+E+ E S++ ++ Q +T+ +
Sbjct: 784 LKLTNL-QENLSEVSQVKETLEKELQILKEKF------AEASEEAVSVQRSMQETVNKLH 836
Query: 178 KRRKK--MISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQK--- 232
++ ++ M+S+ + + F +K + +++ + EN E K
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA----KEKLENDIAEIMKMSG 892
Query: 233 --NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWK 290
++Q+ K+ E+ + + +++ + +L A+ +A K E K E + +
Sbjct: 893 DNSSQLTKMNDELRLKERDVEELQLKLTKANE-NASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 291 EEEKEKL---VDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIG-TLKDA 346
EEEK++L + ++EK E + +EL ++ E SE + + +I N+ TL D
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKAR---YERATSETKTKHEEILQNLQKTLLDT 1008
Query: 347 HE----FKEDRSPYPQDFHNVMQLLDSQESKWTAR-VQAIHQEHKKEKGRLLSHIEKLRT 401
+ +E+ S Q+ + + D ++ TA I ++ KEK L+ +E +
Sbjct: 1009 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1068
Query: 402 SM------IDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKV 455
+ +D L +N+ K +EEL + EL+ + Q++++F + ++ +
Sbjct: 1069 TNAKLQNELDTLKENNL---KNVEELNK----SKELLTVENQKMEEFR-KEIETLKQAAA 1120
Query: 456 NAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRK----- 510
+ + ++ + E S +E++ +K E LNN + ++K
Sbjct: 1121 QKSQQLSALQEENVKLAEELGRSR------DEVTSHQKLEEERSVLNNQLLEMKKRESKF 1174
Query: 511 ---------ALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESE 561
+L+ + S+T L T + L EKL S+ LH V++++ES+
Sbjct: 1175 IKDADEEKASLQKSISITSALLTEKDAEL-EKLRNEVTVLRGENASAKSLHSVVQTLESD 1233
Query: 562 RHKQEREIPNFH-QIREFLEHQVSCKIEEKALLSSDQ-CSVSQMDTLSTGEVPKMIQLPS 619
+ K E ++ N Q++E S D+ SQ+D L++ ++ L
Sbjct: 1234 KVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS----VIVDLQR 1289
Query: 620 KNRQL 624
KN+ L
Sbjct: 1290 KNQDL 1294
Score = 43.9 bits (102), Expect = 6e-04
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 21/293 (7%)
Query: 64 LESVDWRRLSAIDVDKVAGAVDVLTLQENIMNI---TFCKLEDEKCPHCQSGVDPVLLKL 120
L+ ++ R A A D + + E + T LED K + + + LK
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLR----LSHCDGEQSKKLLTKQAGEIKTLKEE 176
L +E L S+E LT + +EE + L ++S++L Q +K +E
Sbjct: 1083 NNLKN--VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Query: 177 CKRRKKMISTQQLMIEAKANYYQCHFCDKA---FMNQAFLQSHIQRRHTEENSHFEYQKN 233
+ R ++ S Q+L E Q K F+ A + ++ S +K+
Sbjct: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1200
Query: 234 AQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEE 293
A++EKLR+E+ VL+ E + ++ H + E K K E +K + +E
Sbjct: 1201 AELEKLRNEVTVLRGE----NASAKSLHSV-----VQTLESDKVKLELKVKNLELQLKEN 1251
Query: 294 KEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA 346
K +L ++ + S+ L + ++Q+ N +K + + +A
Sbjct: 1252 KRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 64.3 bits (155), Expect = 5e-10
Identities = 105/483 (21%), Positives = 191/483 (39%), Gaps = 60/483 (12%)
Query: 139 TSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYY 198
TSQL EE+L D + +K ++ E+K L+++ + +K I + L IE A
Sbjct: 752 TSQLKATEEKL----LDLDALRKASSEGKSEMKKLRQQLEAAEKQI--KHLEIEKNAESS 805
Query: 199 QCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELE 258
+ + + +++Q +E + E L E+ +LKE+ E
Sbjct: 806 KASSITRELQGRELKLTNLQENLSEVSQ--------VKETLEKELQILKEKFA------E 851
Query: 259 AAHHASAVRFSKEYEMQKT--KEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELT 316
A+ A +V+ S + + K KEE F + E+ +E L D K +E +E ++L
Sbjct: 852 ASEEAVSVQRSMQETVNKLHQKEEQF-NMLSSDLEKLRENLADMEAKFREKDERE-EQLI 909
Query: 317 SKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKE--------------DRSPYPQDFHN 362
LE ++EI K + S + + D KE + + + Q
Sbjct: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 969
Query: 363 VMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELG 422
M + Q + A+ H+E KKE R LS +EK + + Y++ E
Sbjct: 970 DMTVKAEQSQQEAAKK---HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK 1026
Query: 423 QR----LQEQNELIITQRQQIK---DFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQ 475
+ LQ + ++ ++K + L + E + A +T + EQ
Sbjct: 1027 TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQ 1086
Query: 476 AFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRK-ALKSNSSLTKGLRTMVEQNLMEKL 534
E E L+ E ++ KL N L++ LK+ L K + +N +K+
Sbjct: 1087 MTK----EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN--QKM 1140
Query: 535 ETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLS 594
E + ++ Q + L +++ E K E+ E HQ K+EE+ +
Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD--EVTSHQ---KLEEERSVL 1195
Query: 595 SDQ 597
++Q
Sbjct: 1196 NNQ 1198
Score = 62.8 bits (151), Expect = 1e-09
Identities = 112/545 (20%), Positives = 232/545 (42%), Gaps = 72/545 (13%)
Query: 118 LKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEEC 177
LKL L Q + + +E L +L L+E+ E S++ ++ Q +T+ +
Sbjct: 819 LKLTNL-QENLSEVSQVKETLEKELQILKEKF------AEASEEAVSVQRSMQETVNKLH 871
Query: 178 KRRKK--MISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQK--- 232
++ ++ M+S+ + + F +K + +++ + EN E K
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA----KEKLENDIAEIMKMSG 927
Query: 233 --NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWK 290
++Q+ K+ E+ + + +++ + +L A+ +A K E K E + +
Sbjct: 928 DNSSQLTKMNDELRLKERDVEELQLKLTKANE-NASFLQKSIEDMTVKAEQSQQEAAKKH 986
Query: 291 EEEKEKL---VDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIG-TLKDA 346
EEEK++L + ++EK E + +EL ++ E SE + + +I N+ TL D
Sbjct: 987 EEEKKELERKLSDLEKKMETSHNQCQELKAR---YERATSETKTKHEEILQNLQKTLLDT 1043
Query: 347 HE----FKEDRSPYPQDFHNVMQLLDSQESKWTAR-VQAIHQEHKKEKGRLLSHIEKLRT 401
+ +E+ S Q+ + + D ++ TA I ++ KEK L+ +E +
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
Query: 402 SM------IDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKV 455
+ +D L +N+ K +EEL + EL+ + Q++++F + ++ +
Sbjct: 1104 TNAKLQNELDTLKENNL---KNVEELNK----SKELLTVENQKMEEFR-KEIETLKQAAA 1155
Query: 456 NAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRK----- 510
+ + ++ + E S +E++ +K E LNN + ++K
Sbjct: 1156 QKSQQLSALQEENVKLAEELGRSR------DEVTSHQKLEEERSVLNNQLLEMKKRESKF 1209
Query: 511 ---------ALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESE 561
+L+ + S+T L T + L EKL S+ LH V++++ES+
Sbjct: 1210 IKDADEEKASLQKSISITSALLTEKDAEL-EKLRNEVTVLRGENASAKSLHSVVQTLESD 1268
Query: 562 RHKQEREIPNFH-QIREFLEHQVSCKIEEKALLSSDQ-CSVSQMDTLSTGEVPKMIQLPS 619
+ K E ++ N Q++E S D+ SQ+D L++ ++ L
Sbjct: 1269 KVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS----VIVDLQR 1324
Query: 620 KNRQL 624
KN+ L
Sbjct: 1325 KNQDL 1329
Score = 43.9 bits (102), Expect = 6e-04
Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 21/293 (7%)
Query: 64 LESVDWRRLSAIDVDKVAGAVDVLTLQENIMNI---TFCKLEDEKCPHCQSGVDPVLLKL 120
L+ ++ R A A D + + E + T LED K + + + LK
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 121 IRLAQFTIEYLLHSQEFLTSQLHTLEERLR----LSHCDGEQSKKLLTKQAGEIKTLKEE 176
L +E L S+E LT + +EE + L ++S++L Q +K +E
Sbjct: 1118 NNLKN--VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175
Query: 177 CKRRKKMISTQQLMIEAKANYYQCHFCDKA---FMNQAFLQSHIQRRHTEENSHFEYQKN 233
+ R ++ S Q+L E Q K F+ A + ++ S +K+
Sbjct: 1176 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1235
Query: 234 AQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEE 293
A++EKLR+E+ VL+ E + ++ H + E K K E +K + +E
Sbjct: 1236 AELEKLRNEVTVLRGE----NASAKSLHSV-----VQTLESDKVKLELKVKNLELQLKEN 1286
Query: 294 KEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA 346
K +L ++ + S+ L + ++Q+ N +K + + +A
Sbjct: 1287 KRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1339
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 63.2 bits (152), Expect = 1e-09
Identities = 83/406 (20%), Positives = 174/406 (42%), Gaps = 49/406 (12%)
Query: 128 IEYLLHSQEFLTSQLHT---LEERLRLSHCDGEQSKKLLTKQAGEI----KTLKEECKRR 180
IE L ++ L+ +L+ +E L+ + ++ +L+ + EI K LK + +R
Sbjct: 183 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 242
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRH--TEENSHFEYQKNAQIEK 238
K ++ QQL EA H + A LQ+ ++ N E + Q EK
Sbjct: 243 KLLLPQQQLQAEAD------HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 296
Query: 239 LRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEK---- 294
++ ++E+ + R + E + + KE +M++ +E W++EEK
Sbjct: 297 IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-------MWEKEEKIREL 349
Query: 295 EKLVDEMEKVKEMFMK-EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDR 353
E+ + E EK++E K + +E + + Q +++ + +I+ +++ E +++
Sbjct: 350 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ 409
Query: 354 SPYPQDFHNVM----QLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTS--MIDDL 407
+ M + + QE K + + I ++ KK + EK+R M+ +
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKK----IREQEEKIREQEEMMQEQ 465
Query: 408 NASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKS 467
+ ++ E ++QEQ E + Q ++I++ E K+ E +
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE---------QEKKIREQEEKIREQEE 516
Query: 468 SLPMVHEQAFSSH--ILEPIEELSE-EEKGRENEQKLNNNKMHLRK 510
+ E+ + + E E++ E EEK R E+K+ ++ LR+
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/407 (19%), Positives = 155/407 (38%), Gaps = 47/407 (11%)
Query: 222 TEENSHFEYQKNA--QIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSK--EYEMQKT 277
TE Y ++A Q+E +++ + ELE A A A + K Y + T
Sbjct: 128 TELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELT 187
Query: 278 KEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIK 337
KE D L L E + + DE EL KN+ L+ +L ++ +I+
Sbjct: 188 KERDALSL-----ELYRNTITDE-------------ELKEKNAKLQEKLQLVESEKSEIQ 229
Query: 338 SNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIE 397
N+ LK E + P Q L + +A++QA +E++ E
Sbjct: 230 LNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 398 KLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNA 457
K+ +++I+E +++QEQ E I Q ++++ + E K+
Sbjct: 289 KMWRQ------------EEKIQEREEKIQEQEEKIREQEEKMR--RQEEMMWEKEEKMRR 334
Query: 458 PALHTLETKSSLPMVHEQAFSSH-ILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNS 516
E + + + E+ I E E+ EEEK RE E++ R+ K
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 517 SLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIR 576
E+ + E+ E + + G +++ + ++ + K R+ +
Sbjct: 395 Q---------EEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 577 EFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQ 623
+ + Q E++ ++ + + + + + KM + K R+
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 63.2 bits (152), Expect = 1e-09
Identities = 93/509 (18%), Positives = 215/509 (42%), Gaps = 48/509 (9%)
Query: 109 CQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAG 168
C S L + ++ Q IE +++ L E L+ + E+ K +T Q
Sbjct: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
Query: 169 EIKTLKEECKRRKKMISTQQ-LMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSH 227
E+ L + +K+ + Q M++AKA+ + + + + + EE S
Sbjct: 1595 EMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF 1654
Query: 228 FEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFD 287
+ + N QI + ++++ ++K+E++ L+ ++ KT+ ++ L +
Sbjct: 1655 QKGELNVQISERKTQLTLIKQEIEKEEENLQVV--------LRQMSKHKTELKNILDMLQ 1706
Query: 288 RWKEE------EKEKLVDEMEKVKEMFMKEFKELTS-------KNSALEYQLSEIQKSNM 334
E + ++ V E+EK + ++E EL + + +E+Q +++
Sbjct: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
Query: 335 QIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLS 394
+I+ + E S +D + + + ++ T RV A +E+ K + S
Sbjct: 1767 EIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQ-TKRVLAAAEENSKME---QS 1822
Query: 395 HIEKLRTSM------IDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLN 448
++EKL ++ +D LN + I + Q+LQE+ E + + ++++ + + LN
Sbjct: 1823 NLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQ-DHLN 1881
Query: 449 SISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHL 508
+ LHT TK ++ EQ + + + I E + + + E++ ++ +
Sbjct: 1882 LAKQ-----DLLHT--TKHQDVLLSEQ---TRLQKDISEWANRFEDCQKEEETKQQQLQV 1931
Query: 509 RKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGIS-SDQLHRVLKSVESERHKQER 567
+ + L + M+ Q L ++ E+ + ++ +Q H++ K + ++ K ++
Sbjct: 1932 LQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
Query: 568 EIPNF----HQIREFLEHQVSCKIEEKAL 592
+ ++R E + C+ EK L
Sbjct: 1992 VLSKVLAAEERVRTLQEEERWCESLEKTL 2020
Score = 49.3 bits (116), Expect = 2e-05
Identities = 110/554 (19%), Positives = 216/554 (38%), Gaps = 67/554 (12%)
Query: 136 EFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEA-K 194
E L+ + L+E+ + Q+K++L A E + E+ K ++ ++L E +
Sbjct: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLA--AAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
Query: 195 ANYYQCHFCDKAFMNQAFLQ------SHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKE 248
N + + Q LQ + +Q H K + + + V+L E
Sbjct: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
Query: 249 ELQLTRSELEAAHHASAVRFSKEYEMQKTK------EEDFLKL---------FDRWKEEE 293
+ +L + E A+ + +E + Q+ + EE+ LKL + +E E
Sbjct: 1901 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1960
Query: 294 KEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDR 353
+ KL +KE + KELT + S L+ LS++ + + + TL++ + E
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV----LAAEERVRTLQEEERWCES- 2015
Query: 354 SPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVF 413
L+ S+ ++ Q+ ++ G LL+ ++K SM D +
Sbjct: 2016 -------------LEKTLSQTKRQLSEREQQLVEKSGELLA-LQKEADSMRADFSLLRNQ 2061
Query: 414 YKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVH 473
+ ++ +++ E + QR Q++ N L E + T+E +
Sbjct: 2062 FLTERKKAEKQVASLKEALKIQRSQLEK---NLLEQKQENSCIQKEMATIELVAQDNHER 2118
Query: 474 EQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKG-LRTMVEQNLME 532
+ + + E +E +K N++ L +M + A+++ S K +RT + +NL +
Sbjct: 2119 ARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSL-KNLNQ 2177
Query: 533 KLETLGINADIRGISSDQLHRVLKSVESERHKQEREIP-----NFHQIREFLEHQVSCKI 587
L L + + ++ L L+S++ E P NF Q+ EH +
Sbjct: 2178 FLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEAL 2237
Query: 588 EEKALLSSDQ-------CSVSQMDTLSTGEVPKMIQLPSKNRQ-------LIRQKAVSTD 633
EK D+ C Q + L G+ L S RQ + A S
Sbjct: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSAS 2297
Query: 634 RTSVPKIKKNVMED 647
S+ +++ ++ ED
Sbjct: 2298 SPSLSQLESSLTED 2311
Score = 44.7 bits (104), Expect = 4e-04
Identities = 92/451 (20%), Positives = 175/451 (38%), Gaps = 47/451 (10%)
Query: 213 LQSHIQRRHTEEN--SHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSK 270
+ H++ + EE + Q ++E+L I L +E + E+E H R +
Sbjct: 1331 IMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQ 1390
Query: 271 EYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQ 330
+ + E +L + E +VDE+E +++ +K EL + L SE+
Sbjct: 1391 KDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELS 1450
Query: 331 KSNMQIKSNIGTLKDA-------HEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQ 383
+ + K+ + DA E+ Q+ + D Q A + + Q
Sbjct: 1451 CTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQ 1510
Query: 384 EHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQ------EQNE------- 430
HK ++ +L I K+ + D + +K EEL Q+LQ E+NE
Sbjct: 1511 -HKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL-QKLQKDIEMAERNEDHHLQVL 1568
Query: 431 -----LIITQRQQIKDFTCNPLNSISEPKV-------NAPALHTLETKSSLPMVHEQAFS 478
L+ +R +++ + E V LH L+ MV +A
Sbjct: 1569 KESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS----MVQAKADL 1624
Query: 479 SHILEPIEELSEEEKGRENEQKLNNNKMHLRKA-LKSNSSLTKGLRTMVEQNLMEKLETL 537
L E E+ E K ++ +K L S K T+++Q + ++ E L
Sbjct: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
Query: 538 GINADIRGISSDQLHRVLKSVESERHK-QEREIPNFHQIREFLEHQVSCKIEEKALLSSD 596
+ +L +L ++ E H+ Q ++ + ++ E + QV+ +EEK L
Sbjct: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV-LEEKLELE-- 1741
Query: 597 QCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQ 627
++ Q+ GE+ QL ++++ I +
Sbjct: 1742 --NLQQISQQQKGEIEWQKQLLERDKREIER 1770
Score = 38.5 bits (88), Expect = 0.027
Identities = 78/374 (20%), Positives = 157/374 (41%), Gaps = 53/374 (14%)
Query: 227 HFEYQK-NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKL 285
H E +K QI + E L+E +QL + EA + S ++ ++ L L
Sbjct: 457 HDEIEKAEQQILRATEEFKQLEEAIQLKKIS-EAGKDLLYKQLSGRLQLVNKLRQEALDL 515
Query: 286 FDRWKEEEKEKLVDEMEKVKEMFMK---------EFKELTSKNSALEYQLSEIQKSNMQI 336
+ E++K+++ + +++K++ + + + ++ S E QL + K Q+
Sbjct: 516 -ELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
Query: 337 KSNIGTL-----KDAHEFKE-----------DRSPYPQDFHNVMQLLDSQESKWTARVQA 380
+S + + K+ E K+ +D V+ L QE T + QA
Sbjct: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGL--QEYLGTIKGQA 632
Query: 381 IHQEHKKEKGR--------LLSHIEKLRTSM-IDDLNASNVFYKKRIEELGQRLQEQNEL 431
+++ K R L+ +E+ R + I ++A N+ +K + EL LQEQ+E+
Sbjct: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENM--RKELAELESALQEQHEV 690
Query: 432 IITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVH-----EQAFSSHILEPIE 486
+ +Q D + + E ++N + K L V EQ+ LE
Sbjct: 691 NASLQQTQGDLSA--YEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER 748
Query: 487 ELSEEEKGR---ENEQKLNNNKMHLR-KALKSNSSLTKGLRTMVEQNLMEKLETLGINAD 542
+ + G+ E++ N+++H + K L+ +++L K + +L ++ L + +
Sbjct: 749 QALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPE 807
Query: 543 IRGISSDQLHRVLK 556
D+L R LK
Sbjct: 808 EVAARVDELRRKLK 821
Score = 31.6 bits (70), Expect = 3.2
Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 14/115 (12%)
Query: 239 LRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLV 298
+ + +V L LQ T L R + E Q +D + F+R+ EE E+L
Sbjct: 226 VENPVVTLPHYLQFTIFHL---------RSLESLEGQPVTTQDRQEAFERFSLEEVERLE 276
Query: 299 DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA-HEFKED 352
++EK M E +EL SK + ++ K N +K K + E K D
Sbjct: 277 RDLEKK----MIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 62.0 bits (149), Expect = 2e-09
Identities = 94/490 (19%), Positives = 197/490 (40%), Gaps = 52/490 (10%)
Query: 128 IEYLLHSQEFLTSQLHT---LEERLRLSHCDGEQSKKLLTKQAGEI----KTLKEECKRR 180
IE L ++ L+ +L+ +E L+ + ++ +L+ + EI K LK + +R
Sbjct: 195 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 254
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKL- 239
K ++ QQL EA H + A LQ+ + EEN + Q EK+
Sbjct: 255 KLLLPQQQLQAEAD------HLGKELQSVSAKLQAQV-----EENELWNRLNQQQEEKMW 303
Query: 240 RSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD 299
R E + + E ++ E + +R E E + ++E+ + W++EEK + +
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIR---EQEEKMRRQEEMM-----WEKEEKMRRQE 355
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQD 359
EM KE M+ +E+ + +L E +I+ ++ + +E Q+
Sbjct: 356 EMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 415
Query: 360 ---------FHNVMQLLDSQESKWTARVQAIHQEHK-------KEKGRLLSHIEKLRTSM 403
+ + QE K + + IH++ K +E+ + EK+R
Sbjct: 416 AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475
Query: 404 IDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTL 463
+ +++I + +++ Q E + Q ++I++ + + +
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535
Query: 464 ETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLR 523
E K Q + E E++ E+EK R E+K+ + +R+ + +R
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK-------IR 588
Query: 524 TMVEQNLMEKLETLGINADIRGISSDQL-HRVLKSVESERHKQEREIPNFHQIREFLEHQ 582
E+ + E+ E + ++ +++ + K E E QE+E Q + E +
Sbjct: 589 EQ-EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Query: 583 VSCKIEEKAL 592
V + +E+ +
Sbjct: 648 VRLRQQEEKM 657
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 61.6 bits (148), Expect = 3e-09
Identities = 86/408 (21%), Positives = 175/408 (42%), Gaps = 44/408 (10%)
Query: 234 AQIEKLRSEIVVLKEELQLTRSE-----LEAAHHASAVRFSKEYEMQKTKEEDFLKLFDR 288
+++E+LR EI EEL + SE E H S V+ E E+ KTK +D
Sbjct: 754 SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE-EIGKTK-DDLATTQSN 811
Query: 289 WKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHE 348
+K ++E + + F +++K + +N + ++ + K + S++G LK
Sbjct: 812 YKSTDQE--FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS 869
Query: 349 FK----EDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLR--TS 402
+K ++++ Q+ N M+ L Q + +Q + +E +L +E+++ T
Sbjct: 870 YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 403 MIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHT 462
DDL + ++L + + + I ++Q++ N++ K + ++T
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR-------NALESLKQHQETINT 982
Query: 463 LETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLN-NNKMHLRKALKSNSSL--- 518
L++K S + + E +E ++ G + +Q L N L +K N +
Sbjct: 983 LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042
Query: 519 TKGLRTMVEQN-LMEKLETLGINADIRGISSDQLHRVLKSVESERH--------KQEREI 569
K + E+N L + LE+ + A+ + +D + ++E++ K+++EI
Sbjct: 1043 RKIFSLIQEKNELQQMLES--VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 570 ---PNFHQIREFLEHQVSC----KIEEKALLSSDQCSVSQMDTLSTGE 610
H I++ E +C ++EEK S Q Q L+ E
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148
Score = 60.5 bits (145), Expect = 7e-09
Identities = 136/691 (19%), Positives = 264/691 (38%), Gaps = 85/691 (12%)
Query: 132 LHSQEFLTSQLHTLE---------ERLRLSHC--DGEQSKKLLTKQAGEIKTLKEECKRR 180
++ E LT Q T + ERLRL+ + ++ K LTK+ +KT+KE + +
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 181 KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR 240
+ AK Q M + + + + E F+ K++ + ++
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKE---KDNETTKIVSEMEQFK-PKDSALLRIE 1420
Query: 241 SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE 300
E++ L + LQ + E+++ +KE + + +E D+ KE KE +
Sbjct: 1421 IEMLGLSKRLQESHDEMKSV--------AKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 301 MEKVKEMFMKE--FKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQ 358
+E +E+ + KE + L LSE + I+ + + D + K +
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 359 DFHNVMQLLDSQESKWTARVQAIHQ--EHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKK 416
+ N+ Q+ + QE +V + Q EH+K K L IE + + L S +
Sbjct: 1533 EQFNIKQISEVQE-----KVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 417 RIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQA 476
I+E + ++ E + +R Q+K+ +T E + + E+
Sbjct: 1588 MIKE-KEEMKRVQEALQIERDQLKE-------------------NTKEIVAKMKESQEKE 1627
Query: 477 FSSHILEPIEELSEEEKGREN-EQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLE 535
+ + + E E+ E+ +++ K++L N LT+ ++ +NL E
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQ----ILHENLEEMRS 1683
Query: 536 TLGINADIRGISS------DQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSC-KIE 588
D+R + DQL L+ + +++ E+ H EHQ + K+
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM--HLKEHQETIDKLR 1741
Query: 589 EKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVME-- 646
+++ S Q D + + K L + I + + ++ K++ V E
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 647 DPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFG---KNTVKSDAD 703
D + +E+ ++ V Q K S K +K +
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 704 GTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQEL 763
EIE+ + + K + E+++ + R N+ + V T E KE LQE
Sbjct: 1862 TLSKLEIENLNLAQK-----LHENLEEMKSVMKERDNLRR-VEETLKLERDQLKESLQET 1915
Query: 764 KCADVEDEDWDISSLEEEISLGKKSGKEQKE 794
K D+E +++E+ + KE KE
Sbjct: 1916 KARDLE--------IQQELKTARMLSKEHKE 1938
Score = 55.1 bits (131), Expect = 3e-07
Identities = 107/541 (19%), Positives = 224/541 (41%), Gaps = 90/541 (16%)
Query: 131 LLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLM 190
L HS + L +Q ++E LR++H ++ ++ + K G + ++ +K +
Sbjct: 1758 LEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN---- 1813
Query: 191 IEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNA-QIEKLRSEIVVLKEE 249
+ A LQ IQ E+ +K+ + +K SE+ LK++
Sbjct: 1814 ------------------SNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 250 LQ---LTRSELEAAHHASAVRFSKEYEMQKT--KEEDFLKLFDRWKEEEKEKLVDEMEKV 304
++ LT S+LE + A + + E K+ KE D L+ + + E+++L + +++
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 305 KEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVM 364
K +++ ++ +L + + + K + L++
Sbjct: 1916 K-----------ARDLEIQQELKTARMLSKEHKETVDKLRE------------------- 1945
Query: 365 QLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNAS---NVFYKK--RIE 419
+ S+ T ++ I ++ K K L I++L+ + L N+ +KK +E
Sbjct: 1946 -----KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEME 2000
Query: 420 ELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTL-ETKSSLPMVHEQAFS 478
+L ++ + QN + + R T S+ E ++ A L K SL M +Q F
Sbjct: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ-FI 2059
Query: 479 SHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGL--RTMVEQNLMEKLET 536
+ + E I + + + ++ L++ + HL ++L+ S K L R + E L
Sbjct: 2060 ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119
Query: 537 LGINADIRGISSDQLHRVLKSVESERHKQEREIP-----------NFHQIREFLEHQVS- 584
L ++ + +L +K+ S + Q + I FH+I + L++ +S
Sbjct: 2120 LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSY 2179
Query: 585 -CKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKN 643
KI+E+ S ++ + +D EV K +L K + L + V + K+ +N
Sbjct: 2180 VTKIKEEQHESINKFEMDFID-----EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQN 2234
Query: 644 V 644
+
Sbjct: 2235 M 2235
Score = 46.6 bits (109), Expect = 1e-04
Identities = 126/615 (20%), Positives = 239/615 (38%), Gaps = 88/615 (14%)
Query: 213 LQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVL------KEELQLTRSELEAAHHASAV 266
LQ I H E+ ++ ++ ++ +E+ +L K+ L R E+E
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 267 RFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQL 326
+ S+E TKE D LK KE L + +++KE + ++ S E L
Sbjct: 1338 QESQEEIKSLTKERDNLKTI-------KEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1390
Query: 327 SEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHK 386
+ +K N K + + +FK P+D + + ++ + + R+Q H E K
Sbjct: 1391 NMKEKDNETTK----IVSEMEQFK------PKD--SALLRIEIEMLGLSKRLQESHDEMK 1438
Query: 387 ---KEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFT 443
KEK L ++++ S D L K+ I+E+ + E E + +K+
Sbjct: 1439 SVAKEKDD-LQRLQEVLQSESDQL-------KENIKEIVAKHLETEEELKVAHCCLKE-- 1488
Query: 444 CNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKG------REN 497
+I+E +VN L ET+ S +A + + I+E+ E+E+ E
Sbjct: 1489 --QEETINELRVN---LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543
Query: 498 EQKLNNNKMHLRKALKSNSSLTKGLRTMVE------------QNLMEKLETLGINADIRG 545
++K+N K +S+L M+E Q ++++ E + +
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
Query: 546 ISSDQLHRVLKSVESE-RHKQEREIPNFHQIREFLEHQVSCKIEE-KALLSSDQCSVSQM 603
I DQL K + ++ + QE+E + C+IE K + + ++ +
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663
Query: 604 DTLSTGEVPKMIQLPSKNRQLIRQKAVSTD---------RTSVPKIKKNVMEDPFP--RK 652
+T E ++ Q+ +N + +R D + ++K+N+ E K
Sbjct: 1664 ET----ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 653 SSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKS-DADGTEGSEI- 710
+ +E QE D +R S + Q + +K+ D E I
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 711 -----EDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQELKC 765
E + K G+ V T+K+ M +N N + + E+ + +L LK
Sbjct: 1780 HMHLKEQQETIDKLRGI-VSEKTDKLSNMQKDLENSNAKL-QEKIQELKANEHQLITLK- 1836
Query: 766 ADVEDEDWDISSLEE 780
DV + +S +E+
Sbjct: 1837 KDVNETQKKVSEMEQ 1851
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 61.6 bits (148), Expect = 3e-09
Identities = 109/578 (18%), Positives = 242/578 (41%), Gaps = 84/578 (14%)
Query: 119 KLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 178
++ +L + + L ++ LT +L T E + EQ K L K E + +E K
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQ------EQMKVALEKSQSEYLKISQE-K 529
Query: 179 RRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAF--------LQSHIQRRHTEENS---- 226
+++ ++ ++L ++ KA + + +A L+S +++ E +
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 227 ---HFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFL 283
H E +KN K EI V+ E+ ++ELE+ H ++++ ++ K + + +
Sbjct: 590 LAVHLEAEKN----KHNKEITVMVEK---HKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 284 KLFDRWKEEEKEKLVDEME-----KVKEMFMKEFKELTSKNSALE---YQLSEIQKSNMQ 335
+ E+EKE L+ + E ++EM K ++L K + LE +LSE+ K+ +
Sbjct: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 336 IKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSH 395
++ + LKD + + + +D Q++ +V +I +EH+
Sbjct: 703 LEEELSVLKDQTDKMK---------QELEAKMDEQKNHHQQQVDSIIKEHEVS------- 746
Query: 396 IEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKV 455
I++ ++ D +N + K+R + L + + +++ + S E +
Sbjct: 747 IQRTEKALKDQINQLELLLKERDKHLKE-----------HQAHVENLEADIKRSEGELQQ 795
Query: 456 NAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSN 515
+ L ++ S HEQ + E + +L ++ E E+ L ++ +A K +
Sbjct: 796 ASAKLDVFQSYQS--ATHEQTKAYE--EQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 516 SSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREI-----P 570
+ Q+LM++LE + + S Q++ ++ +Q ++I
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 571 NFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAV 630
Q+RE + ++ ++ LS+ + S+ ++ E + K + ++QKA
Sbjct: 912 MILQMREGQKKEIEILTQK---LSAKEDSIHILNE----EYETKFKNQEKKMEKVKQKAK 964
Query: 631 STDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQE 668
T +KK +++ K T S++E++
Sbjct: 965 EMQET----LKKKLLDQEAKLKKELENTALELSQKEKQ 998
Score = 56.2 bits (134), Expect = 1e-07
Identities = 118/608 (19%), Positives = 241/608 (39%), Gaps = 68/608 (11%)
Query: 125 QFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMI 184
Q T++ L E + + + +E++ L + +Q K GE++ K + ++++ +
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 185 STQQLMIEAKANYYQCHFCDKAFMNQAF---LQSHIQRRHTEENS------HFEY---QK 232
T+ A+ + H K ++ L+++ Q++ E HF+ +K
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 233 NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYE----MQKTKEEDFLKLFDR 288
+ ++++ +I+ L+ ++ ++ELE KE E K+KEE+ L DR
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETK--------KKELEHVNLSVKSKEEELKALEDR 1628
Query: 289 WKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQ--------LSE----IQKSNMQI 336
+ E KL + K ++ K+L S+ E Q LSE +Q+ ++
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688
Query: 337 KSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQE-------HKKEK 389
LK + + P+ NV + +E+ VQ ++E + EK
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK 1748
Query: 390 GRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNE---LIITQRQQIKDFTCNP 446
+LL + + + + Y++R+ +L +Q+E +I ++++++
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKY 1808
Query: 447 LNSISEPKVNAPALHTLETKSSLPMV--------HEQAFSSHILE-PIEELS-----EEE 492
+++ + ++ K +L V E+ + ILE I+EL ++E
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE 1868
Query: 493 KGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRG---ISSD 549
R ++L +K +AL+ K ++E+N EK ++ + + +
Sbjct: 1869 VHRVEMEEL-TSKYEKLQALQQMDGRNKPTE-LLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Query: 550 QLHRVLKSVESERHKQEREIPNFHQIREFL--EHQVSCKIEEKALLSSDQCSVSQ-MDTL 606
L L E E+ K +EI + L EHQ +I +K + + Q + L
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 607 STGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEE 666
+ QL + + QK + T I K + +S T +
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIA 2046
Query: 667 QEDDDLIR 674
++DDDL R
Sbjct: 2047 EKDDDLKR 2054
Score = 55.1 bits (131), Expect = 3e-07
Identities = 112/555 (20%), Positives = 232/555 (41%), Gaps = 71/555 (12%)
Query: 141 QLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEEC--KRRKKMISTQQLMIEAKANYY 198
QL L+++L D E + LLTKQ E++ K++ + I Q LM + +
Sbjct: 820 QLAQLQQKL----LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
Query: 199 QCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELE 258
+ K+ + + E+ +K I ++R K+E+++ +L
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREG---QKKEIEILTQKLS 932
Query: 259 AAHHASAVRFSKEYEMQ-KTKEEDFLKLFDRWKEEE---KEKLVDEMEKVKEMFMKEFKE 314
A + + ++EYE + K +E+ K+ + KE + K+KL+D+ K+K+ E
Sbjct: 933 AKEDSIHI-LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 315 LTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRS---PYPQDFHNVMQLLDSQE 371
L+ K ++ E+ ++N S+ + + ++ ++ S + ++ ++V+ + + +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 372 SKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNEL 431
++ +Q IH+ +EK + ++ +++ I K I L + +Q+
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQ----KILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 432 IITQRQQIKDFTCNPLNSISEPKVNAPA-LHTLETKSSLPMVHEQAFSSHILEPIEELSE 490
+ ++Q+K + + +NS+++ + A L LE + + E F L ++ L+E
Sbjct: 1108 LNELQEQLKQKSAH-VNSLAQDETKLKAHLEKLEVDLN-KSLKENTFLQEQLVELKMLAE 1165
Query: 491 EEKGRENE--QKLNNNKMHLRKALKSNSSLTKGL--RTMVEQNLMEKL------------ 534
E+K + +E KL + S+ K L +++ + L E+L
Sbjct: 1166 EDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE 1225
Query: 535 --------ETLGI-----NADIRGISSDQLHRVLKSVE---------SERHKQEREIPNF 572
E + I NA + IS Q HR K E SE Q R++
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQ-HRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 573 HQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVST 632
Q + ++EEK +Q + D S + +Q N +Q+A S
Sbjct: 1285 QNTLNISFQQATHQLEEK----ENQIKSMKADIESLVTEKEALQKEGGN----QQQAASE 1336
Query: 633 DRTSVPKIKKNVMED 647
+ + ++KK + E+
Sbjct: 1337 KESCITQLKKELSEN 1351
Score = 53.1 bits (126), Expect = 1e-06
Identities = 96/475 (20%), Positives = 183/475 (38%), Gaps = 53/475 (11%)
Query: 142 LHTLEERLR-----LSHCDG--EQSKKLLTKQAGEIKTLKEECKRR-KKMISTQQLMIEA 193
L TL++R++ L C + K+ T E + L+E+ R +++ + L +
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 194 KANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQ-KNAQIEKLRSEIVVLKEELQL 252
K K + Q + T+ H + K +I +LRS I + + +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 253 TRSELEAAHHASAVRFSKEYEM-QKTKE---------EDFLKLFDRWKEEEKEKLVDEME 302
R + E + A+ K QKT+E ++ +K ++ EEE+ L E+
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 303 KVKEMFMKEFKELTSKNSALEYQL--SEIQKSNMQIKSNIGTLKDAHEFKEDR----SPY 356
+VK+ + K+ + + A +L E+ + ++ + T + EF+E
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE--REFQEQMKVALEKS 518
Query: 357 PQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKK 416
++ + Q + QES A+ + ++K L KLR DL Y+
Sbjct: 519 QSEYLKISQEKEQQES------LALEELELQKKAILTESENKLR-----DLQQEAETYRT 567
Query: 417 RIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQA 476
RI EL L++ + + Q KD V+ A K MV +
Sbjct: 568 RILELESSLEKS---LQENKNQSKDLA-----------VHLEAEKNKHNKEITVMVEKHK 613
Query: 477 FSSHILEPIEELSEEEKGRENEQKLNNNKMHLR-KALKSNSSLTKGLRTMVEQNLMEKLE 535
L+ ++ EK + +Q+ LR K + +L K + + ++ E E
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 536 TLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEK 590
D++ + L L V RHK E E+ + ++ ++ K++E+
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Score = 45.4 bits (106), Expect = 2e-04
Identities = 100/467 (21%), Positives = 181/467 (38%), Gaps = 85/467 (18%)
Query: 77 VDKVAGAVDVLTLQENIMNITFCK----LEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLL 132
V ++ + LT ++N +NI+F + LE+++ I+ + IE L+
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQLEEKE-------------NQIKSMKADIESLV 1317
Query: 133 HSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIE 192
+E L + ++ Q KK L++ + +KEE K +K IS+
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS------ 1371
Query: 193 AKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQL 252
+++ ++Q +NS +K A I LR + K EL
Sbjct: 1372 ---------------LSKQLTDLNVQL----QNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 253 TRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMK-- 310
+L SKE + +D+ F WK++ + + VKE+ ++
Sbjct: 1413 QVQDLSF----KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 311 -EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDS 369
+ KE K+ + E+ + N + G E ++D+S + N+ L S
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKG------EMEDDKSKMEKKESNLETELKS 1522
Query: 370 QESKWTARVQAI--HQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQ---- 423
Q TAR+ + H K + L+ + K D + V + +ELG+
Sbjct: 1523 Q----TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 424 RLQEQNELIITQRQQI---------KDFTCNPLN-SISEPKVNAPALH-TLETKSSLPMV 472
R++E E I+T Q+ K +N S+ + AL LE++S+ +
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLA 1638
Query: 473 H-----EQ---AFSSHILEPIEELSEE-EKGRENEQKLNNNKMHLRK 510
EQ A +L +EE E+ +KG E+ N K+ R+
Sbjct: 1639 ELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685
Score = 32.0 bits (71), Expect = 2.5
Identities = 29/130 (22%), Positives = 54/130 (41%), Gaps = 34/130 (26%)
Query: 240 RSEIVVLKEELQLTRSE--------LEAAHHASAVRFSKEYEMQKTKEEDFLKL-----F 286
+ E+ +LK+E R E LE H+++ + +E+ Q ++E L++
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETI 2020
Query: 287 DRWKEEEKEKLVDEMEKVKEMFMK---------------------EFKELTSKNSALEYQ 325
++ +E E E L E+ ++ K +E+T+K L+ Q
Sbjct: 2021 NKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ 2080
Query: 326 LSEIQKSNMQ 335
L E+QK Q
Sbjct: 2081 LEELQKKYQQ 2090
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 61.6 bits (148), Expect = 3e-09
Identities = 113/490 (23%), Positives = 204/490 (41%), Gaps = 69/490 (14%)
Query: 155 DGEQSKKLL-TKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFL 213
D EQ+ KLL TK +I LK+E S+ ++ E + N Q K + ++ L
Sbjct: 472 DYEQNMKLLQTKYDADINLLKQEHALSASKASS--MIEELEQNVCQL----KQQLQESEL 525
Query: 214 QSHIQRRHTE-----ENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRF 268
Q Q R E E SH ++ + L+SE+ KE+ Q + E A +
Sbjct: 526 QRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
Query: 269 SKEYEMQKTKEED---FLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQ 325
++ E+Q+ + + L+ F R E EK+ EM KE K +LT S E Q
Sbjct: 586 TRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM---KEQMEKVEADLTRSKSLREKQ 642
Query: 326 ----LSEIQKSNMQIKSNIGTLKDAHEFKE---------DRSPYPQDFHNVMQLLDSQES 372
L +++ + + I LK HE ++ ++ +D ++ L+ Q
Sbjct: 643 SKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLR 702
Query: 373 KWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELI 432
+ QE KK ++++ +E + ++L N K+++ ELG L+E+ +
Sbjct: 703 AANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELG-LLREEEKQR 761
Query: 433 ITQRQQIKDFTCNPLNSISEP-KVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEE 491
T+ +I N L + SE K+ H ET+ +L + + L+ IE
Sbjct: 762 ATREHEI---VVNKLKAESEKMKIELKKTHAAETEMTLEKANSK------LKQIE----- 807
Query: 492 EKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQL 551
+E QKL + + + + SSL E+N ++L D+R D+
Sbjct: 808 ---KEYTQKLAKSSQIIAELQTTISSLK-------EENSQQQLAAERRLQDVRQKFEDEK 857
Query: 552 HRVLKSVESERHKQEREIPNFHQIREFLEHQVSC---KIEEKALLSSDQCSV--SQMDTL 606
++++ + + E+ N +QV C K++ K L S +Q + + +T
Sbjct: 858 KQLIRDNDQAIKVLQDELEN-------RSNQVRCAEKKLQHKELESQEQITYIRQEYETK 910
Query: 607 STGEVPKMIQ 616
G +P ++
Sbjct: 911 LKGLMPASLR 920
Score = 48.9 bits (115), Expect = 2e-05
Identities = 97/458 (21%), Positives = 189/458 (41%), Gaps = 71/458 (15%)
Query: 146 EERLRLSHCDGEQSKKLLTKQAGEIKTLKE--ECKRRKKMISTQQLMIEAKANYYQCHFC 203
EE+L+L +K+L ++ EI+ LK K+ + + ++L + + C
Sbjct: 270 EEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVI 329
Query: 204 DKAFMNQAFLQSHIQRRHTEE-NSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHH 262
+ +Q I + TE N+ +E + + + ++ E L+++ EL +
Sbjct: 330 RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 389
Query: 263 ASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSAL 322
+ EY Q +K E ++L E E K +E
Sbjct: 390 VRLNKMESEYMAQTQSTNHMIKEL----EARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
Query: 323 EYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIH 382
+ SE+Q ++K+ TL +++ D+ M+LL ++K+ A + +
Sbjct: 446 QITCSELQ----EVKARRNTL------HKEKDHLVNDYEQNMKLL---QTKYDADINLLK 492
Query: 383 QEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDF 442
QEH + S IE+L ++ + +L Q+LQE + ++QQ++D
Sbjct: 493 QEHALSASKASSMIEEL---------------EQNVCQLKQQLQESE---LQRKQQLRD- 533
Query: 443 TCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQ-KL 501
E K KS L ++E+ +H L+ SE +KG+E+ Q K+
Sbjct: 534 --------QENKFQM-------EKSHLKHIYEK--KAHDLQ-----SELDKGKEDTQKKI 571
Query: 502 NNNKMHLRKALKSNSSLTKGLRTMVEQ---NLMEKLETLGINAD-IRGISSDQLHRV--- 554
+ + L++ + + +T+ R +Q L E + +N++ + +Q+ +V
Sbjct: 572 HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEAD 631
Query: 555 LKSVESERHKQERE-IPNFHQIREFLEHQ-VSCKIEEK 590
L +S R KQ +E + IR+ E Q V K+E +
Sbjct: 632 LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHE 669
Score = 45.1 bits (105), Expect = 3e-04
Identities = 67/331 (20%), Positives = 138/331 (41%), Gaps = 44/331 (13%)
Query: 135 QEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK----RRKKMISTQQLM 190
Q+ L + + +EE L ++++ + K +++TL +C+ ++ I+ + +
Sbjct: 284 QKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKI 343
Query: 191 IEAKANYYQCHFCDKAFMNQAFLQSH---IQRRHTEENSHFEYQKNAQIEKLRSEIVVLK 247
E + K A ++ +Q++HTE N ++ K+ SE +
Sbjct: 344 CEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQT 403
Query: 248 EELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD---EMEKV 304
+ ELEA Q T E + L +++KL+ E+E+
Sbjct: 404 QSTNHMIKELEAR------------VQQLTGEAENSNL-------QRQKLIQEKAELERC 444
Query: 305 KEMFMKEFKELTSKNSALEYQLSEI---QKSNMQI-----KSNIGTLKDAHEFKEDR--S 354
++ E +E+ ++ + L + + + NM++ ++I LK H + S
Sbjct: 445 YQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASS 504
Query: 355 PYPQDFHNVMQLLDS-QESKWTARVQAIHQEHK--KEKGRLLSHIEKLRTSMIDDLNASN 411
+ NV QL QES+ + Q QE+K EK L EK + +L+
Sbjct: 505 MIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGK 564
Query: 412 VFYKKRIEELGQRLQEQNELI--ITQRQQIK 440
+K+I + + L+E+ E + +T+ Q+++
Sbjct: 565 EDTQKKIHKFEEALKEKEEQLTRVTEVQRLQ 595
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 61.2 bits (147), Expect = 4e-09
Identities = 110/530 (20%), Positives = 223/530 (42%), Gaps = 77/530 (14%)
Query: 161 KLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRR 220
K T++ EI+ +K + + ++++IST Q A + QA Q+ +
Sbjct: 137 KSSTEEEMEIEKIKHKLQEKEELISTLQ-----------------AQLTQA--QAEQPAQ 177
Query: 221 HTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEA--------AHHASAVRFSKEY 272
+ E F K Q+++ I L+ +L T++E A A + VR ++
Sbjct: 178 SSTEMEEFVMMKQ-QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236
Query: 273 EMQ-------KTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQ 325
+Q +T+ + L++ R EE +E LV + V ++ +E +N L Q
Sbjct: 237 LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV-DLLQQELTAAEQRNQILSQQ 295
Query: 326 LSEIQKSNMQIKSNIGTLKDAHEFKEDR-----SPYPQDFHNVMQ----LLDSQESKWTA 376
L +++ + +++ + T ++ + ++ + FHN+ + LL+ E A
Sbjct: 296 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA 355
Query: 377 ------RVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNE 430
R A+ Q+HK E SHI L+ + + +A + ++ + LQ++NE
Sbjct: 356 QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK----DQNSKLLQDKNE 411
Query: 431 LIITQR---QQIKDFTCNPLNSISEPKVNAP-ALHTLETKSSLPMVHEQAFSSHILEPIE 486
+ QQ++D IS+ P H +++S P V+ + + E I
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471
Query: 487 ELSEEEKGRENEQ-KLNNNKMHLRKALKSNSSLTKGLRTMVEQNL-------MEKLETLG 538
L + ENE+ L + + L + N L+ + + QN + ++ +
Sbjct: 472 SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD 531
Query: 539 INADIRGISSDQLHR-VLKSVESERHKQER----EIPNFHQIREFLEHQVSCKIEEKALL 593
I A+ R S+++ + VL++ S++HK+ E+ + FL+ Q+ K E+A
Sbjct: 532 I-ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADH 590
Query: 594 S-SDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKK 642
DQ + QM+ + + L + + + +S+P ++K
Sbjct: 591 EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDF---PLMPNEESSLPAVEK 637
Score = 57.8 bits (138), Expect = 4e-08
Identities = 132/619 (21%), Positives = 220/619 (35%), Gaps = 154/619 (24%)
Query: 142 LHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKAN---YY 198
+ + EE +RL E + +L Q ++ EE K + + + E+KA
Sbjct: 2219 IQSKEEEIRLK----EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 199 QCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEEL-------- 250
Q CD L S + EE H + ++ KL SE+ LK++L
Sbjct: 2275 QQKVCDTLQGENKELLSQL-----EETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Query: 251 -----------------------QLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFD 287
+ + +LE AS S+ +E KE+ + L
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 288 RWKE-----------------EEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQ 330
+E +E E L+ + E+ + +E K+ K + L L I+
Sbjct: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 331 KSNMQIKSNIGT-LKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEK 389
K N+Q K+ + + +K + DR D+ Q L+ + + QE E
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDY----QQLEERHLSIILEKDQLIQEAAAEN 2505
Query: 390 GRLLSHIEKLRTSMIDDLNASNVFYKKRI----EELGQRL----QEQNELIITQRQQIKD 441
+L I LR+ M DDLN+ N + E+L Q + +Q +L+ Q QQ K+
Sbjct: 2506 NKLKEEIRGLRSHM-DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564
Query: 442 F--------------------TCNPLNSISEPKVN---------------APALHTLETK 466
N++ E K + + L+ +
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Query: 467 SSLPMVHEQ------------AFSSHILEPIEELSEE---------EKGRENEQKLNNNK 505
+L + H Q A S + I EL EE +K E E KL
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL 2684
Query: 506 MHL-----------RKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRV 554
HL A + + L + L M ++ LM E G+ A I+ R
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG-----RS 2739
Query: 555 LKSVESERHKQEREIPNFHQ-----IREF--LEHQVSCKIEEKALLSSDQCSVSQMDTLS 607
+ S+++ R E+ + ++E L+ Q E ALLS S++ + S
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
Query: 608 TGEVPKM-IQLPSKNRQLI 625
+ K+ QL SK+ QL+
Sbjct: 2800 LSHLEKLNQQLLSKDEQLL 2818
Score = 48.5 bits (114), Expect = 3e-05
Identities = 120/539 (22%), Positives = 200/539 (37%), Gaps = 83/539 (15%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMIS-- 185
+E L + L ++ LEE+L+ S E ++ E + L +E + K IS
Sbjct: 2555 LEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQL 2614
Query: 186 TQQ---LMIEAKANYY--QCHFCDKAFMNQAFLQSHIQRRHTE-ENSHFEYQKNA----- 234
T+Q L E Y Q ++ + L S Q+R E E QK A
Sbjct: 2615 TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG 2674
Query: 235 QIE-KLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQK-----TKEEDFL----K 284
+IE KL+ E+ L + + R+E E A A EM++ TKE L +
Sbjct: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734
Query: 285 LFDRWK---EEEKEKLVDEMEKVKEMFMKEFKELT---------------------SKNS 320
F R + ++ +E++++K + KEL S NS
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS 2794
Query: 321 ALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVM-QLLDSQESKWTARVQ 379
E LS ++K N Q+ S L ED Q F M L + ++ W +
Sbjct: 2795 TEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK 2854
Query: 380 AIHQEHKKEKGRL--------LSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNEL 431
E K++ + ++K +S+ +D + K ++ Q QE EL
Sbjct: 2855 FRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITEL 2914
Query: 432 --IITQRQQIKDFTCNPLNSISEPKVNAP------ALHTLETKSSLPMVHEQAFSSHILE 483
+ Q Q+ +D T I + ++ LH L + S +HE+ L
Sbjct: 2915 HPLKAQLQEYQDKT--KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLM 2972
Query: 484 PIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADI 543
I + ++ +N L + L+S+SS T+ L+ ++ + +
Sbjct: 2973 AISDKDQQLSHLQN----------LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQN 3022
Query: 544 RGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQ 602
++ L L E H++E I + L S +EEK LS C SQ
Sbjct: 3023 LVYETELLRTQLNDSLKEIHQKELRI-------QQLNSNFSQLLEEKNTLSIQLCDTSQ 3074
Score = 45.8 bits (107), Expect = 2e-04
Identities = 102/543 (18%), Positives = 210/543 (38%), Gaps = 61/543 (11%)
Query: 135 QEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEEC---KRRKKMIST--QQL 189
QE L LHT E H ++ K L + E+K EE R K+ I Q
Sbjct: 1432 QEDLIKALHTQLEMQAKEH---DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA 1488
Query: 190 MIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEK---LRSEIVVL 246
+I K + +K+ + L R T+ + E Q +AQ ++ + + +L
Sbjct: 1489 LISRKEALKE----NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALL 1544
Query: 247 KEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKE 306
+EE +E++ + + + + E LKL E+KEKLV E+E +K
Sbjct: 1545 QEERDKLITEMDRS-------LLENQSLSSSCES--LKLALEGLTEDKEKLVKEIESLKS 1595
Query: 307 MFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQL 366
+ E E K+ L+ + + +S + + ++ E Q+ + ++
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK---QELYGKLRS 1652
Query: 367 LDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQ 426
++ + + ++Q QE ++ K + + K + I +L N + + G +
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEK-MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAK 1711
Query: 427 EQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIE 486
E E +++ +K+ + K+ L + F S ++ +
Sbjct: 1712 ECMETLLSSNASMKE-------ELERVKMEYETL-------------SKKFQS-LMSEKD 1750
Query: 487 ELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGI 546
LSEE + +++ + N +K +A + + + T + E E ++ R
Sbjct: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810
Query: 547 SSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTL 606
S+ + S +S ++ + +I +L+ K L Q + TL
Sbjct: 1811 CSES----VPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866
Query: 607 STGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEE 666
+ + Q+ +K+ +L K + + T K N++ + S +T ++EEE
Sbjct: 1867 ENEKNTLLSQISTKDGEL---KMLQEEVT-----KMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 667 QED 669
++D
Sbjct: 1919 KDD 1921
Score = 45.8 bits (107), Expect = 2e-04
Identities = 118/564 (20%), Positives = 218/564 (38%), Gaps = 70/564 (12%)
Query: 116 VLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKE 175
+LL+ E + H E + + L +LR + + ++++K L + E++ +KE
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 176 ECKRRKKMISTQQLMIE-------AKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHF 228
K RK S QQ ++E +A + K M + L S+ + E
Sbjct: 1677 --KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM-ETLLSSNASMKEELERVKM 1733
Query: 229 EYQK-NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFD 287
EY+ + + + L SE L EE+Q + ++E SK+ ++ T++ D
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG-------NVSKQANLEATEKHDNQ---T 1783
Query: 288 RWKEEEKEKLVDEMEKVKEMFM-------------KEFKELTSKNSALEYQLSEIQKSNM 334
EE + + E E+ + M K SK+ + +++ +
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
Query: 335 QIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLS 394
Q+K I L+ E K+ + Q N L SQ S ++ + +E K LL+
Sbjct: 1844 QLKERIAGLE---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE--VTKMNLLN 1898
Query: 395 HIEKLRTSMIDDLNASNVFYKKRIEE-LGQRLQEQNELIITQRQQIKDFTCNPLNSISEP 453
+ S + L + K +EE L +L E N I Q + D SE
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM 1958
Query: 454 KVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALK 513
K + LE + + + S I +E E+ +G + E ++ L++ LK
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIR---KEYLEKIQGAQKEPGNKSHAKELQELLK 2015
Query: 514 SNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFH 573
K L+ + EK+ L ++ + L+ V++E K + EI
Sbjct: 2016 EKQQEVKQLQKDCIR-YQEKISAL-----------ERTVKALEFVQTESQK-DLEITK-E 2061
Query: 574 QIREFLEHQVSCKIE---EKALLSSDQCSVSQM--------DTLSTGEVPKMIQLPSKNR 622
+ + +EH+ + E K LL Q +++ L + + Q+ K+
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
Query: 623 QLIRQKAVSTDRTSVPKIKKNVME 646
L R+ + ++ K KKN+ E
Sbjct: 2122 DLERRLEQAEEKHL--KEKKNMQE 2143
Score = 44.7 bits (104), Expect = 4e-04
Identities = 96/492 (19%), Positives = 197/492 (40%), Gaps = 82/492 (16%)
Query: 233 NAQIEKLRSEIVVLKEELQLTRSELE-------AAHHASAVRFSKEYEMQKTKEEDFLKL 285
N QI++ S + LKE + + +LE A + S + ++ + K E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 286 FDRWK------EEEKEKLVDEMEKVKEMFMKEF--------KELTSKNSALEYQ------ 325
K EEEK++LV E KV+ KE+ KE +K+ A E Q
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017
Query: 326 ---LSEIQKSNMQIKSNIGTLK---DAHEFKEDRSPYPQDF--HNVMQLLDSQESKWT-- 375
+ ++QK ++ + I L+ A EF + S + N+ Q ++ ++
Sbjct: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
Query: 376 ARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQ 435
A + + + + E R+L+ KL+ + + + K++ E+L +RL++ E + +
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137
Query: 436 RQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGR 495
++ +++ L+++ KV H ET + + + ++++ +
Sbjct: 2138 KKNMQE----KLDALRREKV-----HLEETIGEIQVTLNK--------------KDKEVQ 2174
Query: 496 ENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQ----------NLMEKLETLGINADIRG 545
+ ++ L++ L KS SSL ++++ + K E + + D
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 546 ISSDQLHRVLKSVES-----ERHKQEREIPNFHQIREFLEHQVSCKI---EEKALLSSDQ 597
+ DQL ++ +E R + +++I E Q C E K LLS
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS--- 2291
Query: 598 CSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTIT 657
+ + L ++ +L S+ + L Q ++ K +K +E ++ + I
Sbjct: 2292 -QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350
Query: 658 TPPFSSEEEQED 669
FS E+ + D
Sbjct: 2351 NSKFSYEQLETD 2362
Score = 38.9 bits (89), Expect = 0.020
Identities = 51/302 (16%), Positives = 123/302 (40%), Gaps = 31/302 (10%)
Query: 71 RLSAIDVDKVAGAVDVLTLQENIMNITFC----KLEDEKCPHCQSGVDPVLLKLIRLAQF 126
++ ++ +K + V++ TL+E + ++ K + E+ SG+ ++ Q
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQI 972
Query: 127 TIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMIST 186
+ E L H + L + + +L+ + + ++ + +++ E+ LK+E K+ + T
Sbjct: 973 SKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET 1032
Query: 187 QQLMIEA-KANYYQCHFCDKA-------FMNQAFLQSHIQRRHT----EENSHFEYQKNA 234
++ +E K N C + ++ Q + ++ +H EE E Q A
Sbjct: 1033 ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 235 QIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLK---------- 284
++++ + ++ L ++E+ + + +K
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
Query: 285 -LFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTL 343
+ WK E +EK++ +EK KE K+ +E + A+ L + Q+ ++ +
Sbjct: 1153 GSSEHWKPELEEKIL-ALEKEKEQLQKKLQEALTSRKAI---LKKAQEKERHLREELKQQ 1208
Query: 344 KD 345
KD
Sbjct: 1209 KD 1210
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 60.8 bits (146), Expect = 5e-09
Identities = 126/598 (21%), Positives = 247/598 (41%), Gaps = 89/598 (14%)
Query: 85 DVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHT 144
++ L+ENI +T K ++ H Q+ D +++ + + L+ L Q
Sbjct: 985 EMTALEENISKLTKEKKSLQEA-HQQTLDD------LQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 145 LE---ERLRLSHCDGEQSKKLLTKQAGEIKTLKE---ECKRRKKMISTQQLMIEAKANYY 198
LE E+ + D E++K+ K G++K +E + + K+ I + E + +
Sbjct: 1038 LEGSLEQEKKLRADLERAKR---KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL 1094
Query: 199 QCHFCDKAFMNQAF------LQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQL 252
Q D+ + F LQ+ I+ EE E+ A+IEK RS+ L EL+
Sbjct: 1095 QAKIDDEQVHSLQFQKKIKELQARIEE--LEEEIEAEHTLRAKIEKQRSD---LARELEE 1149
Query: 253 TRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEE-------------------- 292
LE A A+ S + EM K +E +F K+ +E
Sbjct: 1150 ISERLEEASGAT----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA 1205
Query: 293 EKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKED 352
E + +D +++VK+ KE EL + + + + KS I+ T++D +F E
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED--QFSEI 1263
Query: 353 RSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNV 412
++ Q + L + AR+Q + E LSH + + S+I L S
Sbjct: 1264 KAKDEQQTQLIHDL-----NMQKARLQTQNGE--------LSHRVEEKESLISQLTKSKQ 1310
Query: 413 FYKKRIEELGQRLQEQNEL--IITQRQQIKDFTCNPLNSISEPKVNAPA--LHTLETKSS 468
+++EEL ++++E+ + + Q C+ L E + A A L +S
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 469 LPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQ 528
+ + ++ EEL E +K + Q+L + + A +SL K +Q
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKK--KLAQRLQEAEENTETANSKCASLEK-----TKQ 1423
Query: 529 NLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIE 588
L ++E L +R + ++ H +++ ++ ++ + + Q + + ++ +
Sbjct: 1424 RLQGEVEDL-----MRDL--ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 589 EKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVME 646
E LS++ + +M V ++ L +N+ L Q+ +S + + KN+ E
Sbjct: 1477 ESRSLSTE---LFKMRNAYEEVVDQLETLRRENKNL--QEEISDLTEQIAETGKNLQE 1529
Score = 58.5 bits (140), Expect = 2e-08
Identities = 109/543 (20%), Positives = 215/543 (39%), Gaps = 97/543 (17%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
I L S++ LT QL L+ ++ E+ K A +++ + +C ++ +
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQM-------EEETKAKNAMAHALQSSRHDCDLLREQYEEE 1354
Query: 188 QLMIEAKANYYQCHF---CDKAFMNQAFLQSHIQR---------------RHTEENSHFE 229
Q EAKA + + A + IQR + EEN+
Sbjct: 1355 Q---EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 230 YQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRW 289
K A +EK + L+ E++ +LE +H A A K+ +F K+ W
Sbjct: 1412 NSKCASLEKTKQR---LQGEVEDLMRDLERSHTACATL--------DKKQRNFDKVLAEW 1460
Query: 290 KEEEKEKLVDEMEKVKEMFMKEFKELTSK----NSALEYQLSEIQKSNMQIKSNIGTLKD 345
K++ +DE + E KE + L+++ +A E + +++ + K+ + D
Sbjct: 1461 KQK-----LDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 346 AHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMID 405
E + Q+ +L++ ++S ++ + + E+ ++L ++ + +
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL-RVQLELSQVKS 1574
Query: 406 DLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPA-LHTLE 464
+L+ + + IE+L + Q E + Q + D N K L+ +E
Sbjct: 1575 ELDRKVIEKDEEIEQLKRNSQRAAEAL----QSVLDAEIRSRNDALRLKKKMEGDLNEME 1630
Query: 465 TKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQ-KLNNNKMHLRKALKSNSSLTKGLR 523
+ + H +++E +K Q +L ++++HL AL+SN L + L
Sbjct: 1631 ----IQLGHSN----------RQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 524 TMVEQN--LMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEH 581
+ +N L+E+LE + + L+ E R E+E+ + + L
Sbjct: 1677 IVERRNGLLLEELEEMKV--------------ALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 582 QVSCKIEEKALLSSD--QCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPK 639
Q + I K L +D QC EV IQ S+N + +KA++ +
Sbjct: 1723 QNTSLINTKKKLEADIAQCQ---------AEVENSIQ-ESRNAEEKAKKAITDAAMMAEE 1772
Query: 640 IKK 642
+KK
Sbjct: 1773 LKK 1775
Score = 42.7 bits (99), Expect = 0.001
Identities = 81/400 (20%), Positives = 158/400 (39%), Gaps = 47/400 (11%)
Query: 223 EENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDF 282
+E + + Q ++ E L + E L ++ LEA R +E EM
Sbjct: 886 QEKNDLQLQVQSETENLM-DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK 944
Query: 283 LKLFDRWKE-----EEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIK 337
L D+ ++ E + ++EK K + K L+ + +ALE +S++ K
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK--- 1001
Query: 338 SNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKK-------EKG 390
+L++AH+ D +D N + ++++ + T ++ ++ KK K
Sbjct: 1002 ----SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057
Query: 391 RLLSHIEKLRTSMIDDLNASNVFYKK------RIEELGQRLQEQNELIITQRQQIKDFTC 444
+L ++ + S++D N +K + +L ++ ++ + +++IK+
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 445 NPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNN 504
I E + A HTL K + +++ + LE I E EE G + Q N
Sbjct: 1118 R----IEELEEEIEAEHTLRAK----IEKQRSDLARELEEISERLEEASGATSAQIEMNK 1169
Query: 505 K-----MHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVE 559
K +R+ L+ + + + + + + LG D L RV + +E
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI-------DNLQRVKQKLE 1222
Query: 560 SERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCS 599
E+ + + EI + E L S IE DQ S
Sbjct: 1223 KEKSELKMEIDDMASNIEALSKSKS-NIERTCRTVEDQFS 1261
Score = 30.0 bits (66), Expect = 9.4
Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 16/128 (12%)
Query: 498 EQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKS 557
E K+ L + + NS L R NL +K +L DI D L L
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKR-----NLEDKCSSL--KRDI-----DDLELTLTK 967
Query: 558 VESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGE--VPKMI 615
VE E+H E ++ N + LE +S +EK S + +D L E V +I
Sbjct: 968 VEKEKHATENKVKNLSEEMTALEENISKLTKEKK--SLQEAHQQTLDDLQVEEDKVNGLI 1025
Query: 616 QLPSKNRQ 623
++ +K Q
Sbjct: 1026 KINAKLEQ 1033
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 60.8 bits (146), Expect = 5e-09
Identities = 119/583 (20%), Positives = 232/583 (39%), Gaps = 106/583 (18%)
Query: 126 FTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMIS 185
F I+ LL S E ++ T++E +++K L K + K L+E+ K +
Sbjct: 837 FKIKPLLKSAE-TEKEMATMKEEF-------QKTKDELAKSEAKRKELEEKMVTLLKEKN 888
Query: 186 TQQLMIEAKANYYQC--HFCDKAFMNQAFLQSHIQR--RHTEENSHFEYQKNAQIEKLRS 241
QL ++++A+ C++ N+ L++ I+ EE + A+ KL
Sbjct: 889 DLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLED 948
Query: 242 EIVVLK---EELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWK--EEEKEK 296
E LK ++L+LT +++E HA+ + E +E KL K +E ++
Sbjct: 949 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ 1008
Query: 297 LVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPY 356
+D+++ ++ + LT + LE Q+ +++ G+L+ + + D
Sbjct: 1009 TLDDLQAEED----KVNILTKAKTKLEQQVDDLE----------GSLEQEKKLRMDLERA 1054
Query: 357 PQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKK 416
+ ++L Q + ++ +K++ + + I K I+D A + +K
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK-----IEDEQAVEIQLQK 1109
Query: 417 RIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQA 476
+I+EL R++E E I +R A + +S L E+
Sbjct: 1110 KIKELQARIEELGEEIEAER--------------------ASRAKAEKQRSDLSRELEE- 1148
Query: 477 FSSHILEPIEEL-----SEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLM 531
I E +EE ++ E ++ E + + L +A + ++ LR ++
Sbjct: 1149 ----ISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 532 EKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIP--------------NFHQIRE 577
E E + D L RV + +E E+ + + E N ++
Sbjct: 1205 ELGEQI-----------DNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 578 FLEHQVS---CKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKN---RQLIRQKAVS 631
LE QVS K EE+ L +D + GE + QL K+ QL R K S
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR--QLDEKDALVSQLSRSKQAS 1311
Query: 632 TDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIR 674
T + + ++K + E+ + + + + + D DL+R
Sbjct: 1312 TQQ--IEELKHQLEEETKAKNALA-----HALQSSRHDCDLLR 1347
Score = 37.4 bits (85), Expect = 0.059
Identities = 81/461 (17%), Positives = 185/461 (40%), Gaps = 65/461 (14%)
Query: 157 EQSKKLLTKQAGE----IKTLKEECKRRKK-----MISTQQLMIEAKANYYQCHFCDKAF 207
E++KK L ++ E ++ + +C +K + LM++ + + C DK
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449
Query: 208 MNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVR 267
N + S ++++ E + E + + L +E+ +K + + +LE +
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQK-ESRSLSTELFKVKNVYEESLDQLETLRREN--- 1505
Query: 268 FSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLS 327
K +++ L ++ E K+ + E+EK+K+ +E E+ + E L
Sbjct: 1506 --------KNLQQEISDLTEQIAEGGKQ--IHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 328 EIQKSNMQIKSNIGTLKDAHEFK--EDRSPYPQDFHNVMQLLDSQESKWTARVQAIH--- 382
+ ++I+ + +K + K E Q N +++++ +S A +++ +
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL 1615
Query: 383 QEHKKEKGRL------LSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNEL----- 431
+ KK +G L L+H +L + + + K+ L L+ Q +L
Sbjct: 1616 RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLA 1675
Query: 432 IITQRQQIKDFTCNPLNSISEPKVNAPAL---HTLETKSSLPMVHEQAFS---------- 478
I+ +R + L + E + + L+ + ++H Q S
Sbjct: 1676 IVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEN 1735
Query: 479 --SHILEPIEELSEEEKGRENE-QKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLE 535
S + +EE+ +E + E + +K + + + LK + L M ++NL + ++
Sbjct: 1736 DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-KKNLEQTVK 1794
Query: 536 TLGINADIRGISSDQL-----HRVLKSVESERHKQEREIPN 571
L D ++QL + ++ +E+ + E E+ N
Sbjct: 1795 DLQHRLD----EAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
>gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
Length = 1079
Score = 60.5 bits (145), Expect = 7e-09
Identities = 92/471 (19%), Positives = 205/471 (43%), Gaps = 44/471 (9%)
Query: 145 LEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR-----KKMISTQQLMIEAKANYYQ 199
LE+ +R + ++ L KQ EI +LK+E K+ K ++ Q M E N
Sbjct: 185 LEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTI 244
Query: 200 CHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEA 259
+ + ++ + + EE +H + +K I + +L++++Q +E+EA
Sbjct: 245 KEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQ-ANTEMEA 303
Query: 260 AHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKN 319
++ KE ++ + + + EE+ L +E EK + + +EL +
Sbjct: 304 -----ELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEI 358
Query: 320 SALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQ 379
+ ++ +LS +++++++++ + L + F+ED+ F NV ++ + T + +
Sbjct: 359 NKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKK-----FQNVPEVNNENSEMSTEKSE 413
Query: 380 -AIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQ 438
I Q++ E +++R +++ + + +K ++ G ++ E+II Q
Sbjct: 414 NTIIQKYNTE--------QEIREENMENFCSDTEYREKEEKKEGSFIE---EIIIDDLQL 462
Query: 439 IKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELS--------- 489
+ N ++++ N + +T S V Q +S++ + + ++
Sbjct: 463 FEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICL 522
Query: 490 EEEKGRENEQKLNNNKMHLRKAL---KSNSSLTKGLRT-MVEQNLMEKLETLGINADIRG 545
E++ G + NN+ + L A+ K + T+GL + NL + N+ +
Sbjct: 523 EKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNE 582
Query: 546 ISSDQLHRVLKSV-ESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSS 595
+ + H K V E+E KQ R +P + LE +++ + KA L S
Sbjct: 583 TAHNTYHNNNKDVSENEPFKQFRLLPGTRE--HALEKEITNSDQTKADLDS 631
Score = 53.9 bits (128), Expect = 6e-07
Identities = 83/320 (25%), Positives = 136/320 (42%), Gaps = 43/320 (13%)
Query: 219 RRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKT- 277
R E H+E Q I + + E+ KE LQ + L H + F K+ +M+
Sbjct: 42 RMRREAEIHYEEQIGKIIVETQ-ELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCA 100
Query: 278 --KEEDFLKLFDRWKEEEKEKLVDEME-----------KVKEMFMKEFKELTSKNSALEY 324
+E+ +L KE+E E L + ++ KV EM K L +K
Sbjct: 101 LEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKED-YHK 159
Query: 325 QLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQ---LLDSQESKWTARVQAI 381
QLSEI+K I G +K+ HE E Q+ +Q L + K A + ++
Sbjct: 160 QLSEIEKYYATITGQFGLVKENHEKLE------QNVREAIQSNKRLSALNKKQEAEICSL 213
Query: 382 HQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQ---EQNELI---ITQ 435
+E KK L+ + M ++ N + +++ +EL +RL E NE I IT
Sbjct: 214 KKELKKAASDLIKSKVTCQYKMGEE-NINLTIKEQKFQELQERLNMELELNEKINEEITH 272
Query: 436 RQQIKD---FTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEE 492
Q+ K + + + ++ A E ++ L ++ E ++ LE EL + E
Sbjct: 273 IQEEKQDIIISFQHMQQLLRQQIQA----NTEMEAELKVLKE---NNQTLERDNEL-QRE 324
Query: 493 KGRENEQKLNNNKMHLRKAL 512
K +ENE+K N + KAL
Sbjct: 325 KVKENEEKFLNLQNEHEKAL 344
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 60.5 bits (145), Expect = 7e-09
Identities = 128/586 (21%), Positives = 237/586 (40%), Gaps = 112/586 (19%)
Query: 126 FTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMIS 185
F I+ LL S E + EE E++K+ L K + K L+E+ + +
Sbjct: 838 FKIKPLLKSAETEKEMANMKEEF--------EKTKEELAKTEAKRKELEEKMVTLMQEKN 889
Query: 186 TQQLMIEAKANYYQC--HFCDKAFMNQAFLQSHIQR--RHTEENSHFEYQKNAQIEKLRS 241
QL ++A+A+ CD+ + L++ I+ E+ + A+ KL
Sbjct: 890 DLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 949
Query: 242 EIVVLK---EELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWK--EEEKEK 296
E LK ++L+LT +++E HA+ + E +E KL K +E ++
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 297 LVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPY 356
+D+++ ++ + LT + LE Q+ +++ S Q K L+ A E
Sbjct: 1010 TLDDLQMEED----KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 357 PQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKK 416
Q+ +D++ K Q ++++ KK++ + S+++ I+D A + +K
Sbjct: 1066 AQE-----STMDTENDK-----QQLNEKLKKKEFEM-SNLQ----GKIEDEQALAIQLQK 1110
Query: 417 RIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQA 476
+I+EL R++E E I +R +S +Q
Sbjct: 1111 KIKELQARIEELEEEIEAER------------------------------ASRAKAEKQ- 1139
Query: 477 FSSHILEPIEELSE--EEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKL 534
S + +EE+SE EE G ++ NK K + K R + E L +
Sbjct: 1140 -RSDLSRELEEISERLEEAGGATSAQIEMNK-------KREAEFQKMRRDLEESTLQHEA 1191
Query: 535 ETLGI---NADI---RGISSDQLHRVLKSVESERHKQEREI--------------PNFHQ 574
+ +AD G D L RV + +E E+ + + EI NF +
Sbjct: 1192 TAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK 1251
Query: 575 IREFLEHQVS---CKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKN---RQLIRQK 628
+ LE Q+S K EE+ L ++ + +GE + QL K+ QL R K
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSR--QLDEKDAMVSQLSRGK 1309
Query: 629 AVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIR 674
T + + ++K+ + E+ + +T + + + D DL+R
Sbjct: 1310 QAFTQQ--IEELKRQLEEE-----TKAKSTLAHALQSARHDCDLLR 1348
Score = 48.5 bits (114), Expect = 3e-05
Identities = 82/425 (19%), Positives = 175/425 (41%), Gaps = 53/425 (12%)
Query: 157 EQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFM-------N 209
E+ + L Q EIKT +EE +R +S Q+ + ++ + +K M
Sbjct: 1250 EKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGK 1309
Query: 210 QAFLQSHIQ-RRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRF 268
QAF Q + +R EE + + ++ R + +L+E+ + E +A +
Sbjct: 1310 QAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE-EEQEAKAELQRGMSKA 1368
Query: 269 SKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSE 328
+ E +TK E + + +E+E+ K+ + ++ A+ + +
Sbjct: 1369 NSEVAQWRTK-----------YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 329 IQKSNMQIKSNIGTLK-DAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKK 387
++K+ ++++ + L D + N ++L + K+ QA + +K
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKY-EETQAELEASQK 1476
Query: 388 EKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPL 447
E L + + K++ + Y++ ++ L +E L +Q+I D T
Sbjct: 1477 ESRSLSTELFKVKNA-----------YEESLDHLETLKRENKNL----QQEISDLT---- 1517
Query: 448 NSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGR--ENEQKLNNNK 505
I+E +H LE K + HE++ LE E E E+G+ + +LN K
Sbjct: 1518 EQIAE---GGKHIHELE-KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 506 MHL-RKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHK 564
+ RK + + L + +++N + +E++ D S + R+ K +E + ++
Sbjct: 1574 SEIDRKIAEKDEELDQ-----LKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE 1628
Query: 565 QEREI 569
E ++
Sbjct: 1629 MEIQL 1633
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/365 (23%), Positives = 144/365 (39%), Gaps = 63/365 (17%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
I++LL +E Q TL + L GE+ T C++ +K +
Sbjct: 106 IQHLLSEREEALKQHKTLSQEL--------------VNLRGELVTASTTCEKLEKARNEL 151
Query: 188 QLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRS----EI 243
Q + EA F+Q H Q TE + + + EKLR E
Sbjct: 152 QTVYEA------------------FVQQH-QAEKTERENRLKEFYTREYEKLRDTYIEEA 192
Query: 244 VVLKEELQLTRSELEAAHHASAVRF----SKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD 299
K +LQ L AAH S + S++ E+ K E L + E EK+ L D
Sbjct: 193 EKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLED 252
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQL-SEIQKSNMQIKSN------------IGTLKDA 346
+ + +E K+ +L S+N AL +L SE QK + K+N + +LK
Sbjct: 253 LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 312
Query: 347 HEFKEDRSPYPQDFHNV-MQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMID 405
E K ++ + QD + M+ L + +++ QE+++ K R+ H+ R +
Sbjct: 313 LEIKNEKL-HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 371
Query: 406 DLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLET 465
K+ ++ +RL +NE ++ + C+P S P +A L +
Sbjct: 372 QAVLQESLEKE--SKVNKRLSMENEELLWKLH--NGDLCSPKRS---PTSSAIPLQSPRN 424
Query: 466 KSSLP 470
S P
Sbjct: 425 SGSFP 429
>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
Length = 1270
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/365 (23%), Positives = 144/365 (39%), Gaps = 63/365 (17%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
I++LL +E Q TL + L GE+ T C++ +K +
Sbjct: 940 IQHLLSEREEALKQHKTLSQEL--------------VNLRGELVTASTTCEKLEKARNEL 985
Query: 188 QLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRS----EI 243
Q + EA F+Q H Q TE + + + EKLR E
Sbjct: 986 QTVYEA------------------FVQQH-QAEKTERENRLKEFYTREYEKLRDTYIEEA 1026
Query: 244 VVLKEELQLTRSELEAAHHASAVRF----SKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD 299
K +LQ L AAH S + S++ E+ K E L + E EK+ L D
Sbjct: 1027 EKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLED 1086
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQL-SEIQKSNMQIKSN------------IGTLKDA 346
+ + +E K+ +L S+N AL +L SE QK + K+N + +LK
Sbjct: 1087 LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 1146
Query: 347 HEFKEDRSPYPQDFHNV-MQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMID 405
E K ++ + QD + M+ L + +++ QE+++ K R+ H+ R +
Sbjct: 1147 LEIKNEKL-HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 1205
Query: 406 DLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLET 465
K+ ++ +RL +NE ++ + C+P S P +A L +
Sbjct: 1206 QAVLQESLEKE--SKVNKRLSMENEELLWKLH--NGDLCSPKRS---PTSSAIPLQSPRN 1258
Query: 466 KSSLP 470
S P
Sbjct: 1259 SGSFP 1263
>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
Length = 1216
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/365 (23%), Positives = 144/365 (39%), Gaps = 63/365 (17%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
I++LL +E Q TL + L GE+ T C++ +K +
Sbjct: 886 IQHLLSEREEALKQHKTLSQEL--------------VNLRGELVTASTTCEKLEKARNEL 931
Query: 188 QLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRS----EI 243
Q + EA F+Q H Q TE + + + EKLR E
Sbjct: 932 QTVYEA------------------FVQQH-QAEKTERENRLKEFYTREYEKLRDTYIEEA 972
Query: 244 VVLKEELQLTRSELEAAHHASAVRF----SKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD 299
K +LQ L AAH S + S++ E+ K E L + E EK+ L D
Sbjct: 973 EKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLED 1032
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQL-SEIQKSNMQIKSN------------IGTLKDA 346
+ + +E K+ +L S+N AL +L SE QK + K+N + +LK
Sbjct: 1033 LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 1092
Query: 347 HEFKEDRSPYPQDFHNV-MQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMID 405
E K ++ + QD + M+ L + +++ QE+++ K R+ H+ R +
Sbjct: 1093 LEIKNEKL-HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 1151
Query: 406 DLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLET 465
K+ ++ +RL +NE ++ + C+P S P +A L +
Sbjct: 1152 QAVLQESLEKE--SKVNKRLSMENEELLWKLH--NGDLCSPKRS---PTSSAIPLQSPRN 1204
Query: 466 KSSLP 470
S P
Sbjct: 1205 SGSFP 1209
>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
Length = 517
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/365 (23%), Positives = 144/365 (39%), Gaps = 63/365 (17%)
Query: 128 IEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQ 187
I++LL +E Q TL + L GE+ T C++ +K +
Sbjct: 187 IQHLLSEREEALKQHKTLSQEL--------------VNLRGELVTASTTCEKLEKARNEL 232
Query: 188 QLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRS----EI 243
Q + EA F+Q H Q TE + + + EKLR E
Sbjct: 233 QTVYEA------------------FVQQH-QAEKTERENRLKEFYTREYEKLRDTYIEEA 273
Query: 244 VVLKEELQLTRSELEAAHHASAVRF----SKEYEMQKTKEEDFLKLFDRWKEEEKEKLVD 299
K +LQ L AAH S + S++ E+ K E L + E EK+ L D
Sbjct: 274 EKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLED 333
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQL-SEIQKSNMQIKSN------------IGTLKDA 346
+ + +E K+ +L S+N AL +L SE QK + K+N + +LK
Sbjct: 334 LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 393
Query: 347 HEFKEDRSPYPQDFHNV-MQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMID 405
E K ++ + QD + M+ L + +++ QE+++ K R+ H+ R +
Sbjct: 394 LEIKNEKL-HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
Query: 406 DLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLET 465
K+ ++ +RL +NE ++ + C+P S P +A L +
Sbjct: 453 QAVLQESLEKE--SKVNKRLSMENEELLWKLH--NGDLCSPKRS---PTSSAIPLQSPRN 505
Query: 466 KSSLP 470
S P
Sbjct: 506 SGSFP 510
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 59.3 bits (142), Expect = 1e-08
Identities = 112/580 (19%), Positives = 229/580 (39%), Gaps = 51/580 (8%)
Query: 129 EYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEE--CKRRKKMIST 186
E L +E T + LE + R ++ ++LL ++ + + + E C+ +++
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 187 QQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEK-LRSEIVV 245
++ ++ + + ++ + + +Q ++ EE E ++ ++E+ R E +
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP---EKRRRQELERQYREEEEL 1176
Query: 246 LKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDR-------WKEEEKEKLV 298
+EE QL R E E ++ +E E+Q+ K + + D+ W+ E++ +
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236
Query: 299 DEMEKVKEMFMKEFKELTSKN-------SALEYQLSEIQKSNMQIKSNIGTLKDAHEFKE 351
D K ++F++L L++ L E Q+ + + + +D H +E
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 352 DRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDD-LNAS 410
++ + + SQE K R + + ++E R E+L + L
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 411 NVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKV--NAPALHTLETKSS 468
K R EEL R QEQ + + Q+++ E K L E +
Sbjct: 1357 ERDRKFREEEL--RHQEQGRKFLEEEQRLR-------RQERERKFLKEEQQLRCQEREQQ 1407
Query: 469 LPMVHEQAFSSHILEPIEELSEEE---KGRENEQKLNNNKMHLRKALKSNSSLT--KGLR 523
L ++ F E ++LS +E K RE EQ++ + RK L+ L + +
Sbjct: 1408 LRQDRDRKFR----EEEQQLSRQERDRKFREEEQQVRRQERE-RKFLEEEQQLRQERHRK 1462
Query: 524 TMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLE--- 580
E+ L+++ E ++ R + + L+ E +R +E+E+ + R+FLE
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Query: 581 ------HQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDR 634
Q EE+ L ++ + D + ++ + +QL RQ+ R
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 635 TSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIR 674
K+++ E F + + QE D R
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Score = 43.1 bits (100), Expect = 0.001
Identities = 87/466 (18%), Positives = 187/466 (40%), Gaps = 57/466 (12%)
Query: 135 QEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLK----EECKRRKKMISTQQLM 190
Q+ Q E++LR + + ++L +Q E + + ++ +R +++ QQL
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 191 IEAKANYYQCHFCDKAFMNQAFLQSHIQ-RRHTEENSHFE-YQKNAQIEKLRSEIVVLKE 248
E + Q ++ + L+ Q RR EE H + +++ + ++L+ E +E
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE---QEE 453
Query: 249 ELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMF 308
+ E E H R + ++++ +EE+ + + + +EEE+ + + E+
Sbjct: 454 RRDWLKREEETERHEQERR---KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 309 MKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLD 368
+E +E K E +L + +S Q++ ++ E +E QLL
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLR------REQEERRE-------------QLLK 551
Query: 369 SQESK---WTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRL 425
+E K R Q + +E ++ + +LL E+ R + + + + EE+ +
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 426 QEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPI 485
QE+ +R++ ++ L E E + + EQ
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQ----------EERRQQQLRREQQERRE----- 656
Query: 486 EELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRG 545
+ L EE+ EQ+L R+ + + R ++ + + L AD R
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR- 715
Query: 546 ISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKA 591
+++ + E +R +QE+E + R E ++ + EE+A
Sbjct: 716 --QSKVYSRPRKQEGQRRRQEQE-----EKRRRRESELQWQEEERA 754
Score = 40.0 bits (92), Expect = 0.009
Identities = 90/439 (20%), Positives = 173/439 (39%), Gaps = 65/439 (14%)
Query: 146 EERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDK 205
E+R + EQ ++ ++ E++ L+EE ++ ++ QQL E D
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEE-EQLQRRERAQQLQEEE----------DG 855
Query: 206 AFMNQAFLQSHIQRR----------HTEENSHFEYQKNAQIEKLRSEIVVL-KEELQLTR 254
+Q +S QRR + H Y K A E+LR E +L +EE +L R
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 255 SELEAAHHASAVRFSKEYEMQKTKEEDFLK-LFDRWKEEEKEKLVDEMEKVKEMFMKEFK 313
E E R +E E + +EE L+ ++ + +E+E+ + +K+++ +
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 314 ELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESK 373
E K E + ++ +Q + L++ E K R + + + +L +E
Sbjct: 976 EEPEKRRRQEREKKYREEEELQ-QEEEQLLREERE-KRRRQEWERQYRKKDELQQEEE-- 1031
Query: 374 WTARVQAIHQEHKK----EKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQN 429
Q + +E +K E+ R E+L+ L +R +EL ++ +++
Sbjct: 1032 -----QLLREEREKRRLQERERQYREEEELQQEEEQLLGEER--ETRRRQELERQYRKEE 1084
Query: 430 ELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELS 489
EL + Q +++ EP+ + + + E+ E+L
Sbjct: 1085 ELQQEEEQLLRE----------EPEKRRRQERERQCREEEELQQEE----------EQLL 1124
Query: 490 EEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSD 549
EE+ + Q+L + + L LR E+ ++LE + +
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQL---LREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 550 QLHRVLKSVESERHKQERE 568
QL R E E+ +QERE
Sbjct: 1182 QLLR----EEQEKRRQERE 1196
Score = 38.9 bits (89), Expect = 0.020
Identities = 84/470 (17%), Positives = 180/470 (38%), Gaps = 56/470 (11%)
Query: 218 QRRHTEENSHFEYQKNAQI-----EKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEY 272
Q R +E E++K + EKL+ E + ELQ +L R +E
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 273 EMQK---TKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKEL-TSKNSALEYQL-- 326
E Q+ +E+ + + + E++E+ ++ E+ ++ + ++L + E QL
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 327 -SEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQE---SKWTARVQAIH 382
E ++ Q++ + E +E + Q QL Q+ + R Q +
Sbjct: 354 EQEEERREQQLRR-----EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 383 QEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDF 442
+E + + + L ++LR ++ + ++R + L + +E+ + + + + +
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER-- 466
Query: 443 TCNPLNSISEPKVNAPALHTLE-TKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKL 501
H E K L E+ L+ EE E++ R +Q
Sbjct: 467 ------------------HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 502 NNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESE 561
+ + LK R E+ L ++L + +R ++ ++LK E +
Sbjct: 509 REQEERREQRLK---------RQEEEERLQQRLRS---EQQLRREQEERREQLLKREEEK 556
Query: 562 RHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMD-TLSTGEVPKMIQLPSK 620
R +QER + +E Q+ + EE+ + +++ L EV ++ Q +
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 621 NRQLIRQKAVSTDRTSVPKIKKNV--MEDPFPRKSSTITTPPFSSEEEQE 668
++L R++ R + K ++ + R+ EEE+E
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Score = 37.4 bits (85), Expect = 0.059
Identities = 67/330 (20%), Positives = 131/330 (39%), Gaps = 57/330 (17%)
Query: 129 EYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTK---QAGEIKTLKEECKRRKKMIS 185
E L Q+ L + L+ R EQ ++ + Q E + L+EE ++R++
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 186 TQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVV 245
+Q + K + + L ++R +E +K R E +
Sbjct: 957 ERQYRKDKKLQQKE----------EQLLGEEPEKRRRQERE----------KKYREEEEL 996
Query: 246 LKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKL-------- 297
+EE QL R E E R +E+E Q K+++ + ++ EE+EK
Sbjct: 997 QQEEEQLLREEREK-------RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 298 ---VDEMEKVKEMFMKEFKELTSKNSALEYQL---SEIQKSNMQIKSNIGTLKDAHEFKE 351
+E+++ +E + E +E T + LE Q E+Q+ Q+ + E +
Sbjct: 1050 YREEEELQQEEEQLLGEERE-TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 352 DRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASN 411
+ QLL + K R Q + +++++E+ + LR
Sbjct: 1109 QCREEEELQQEEEQLLREEREK--RRRQELERQYREEEEVQQEEEQLLREEP-------- 1158
Query: 412 VFYKKRIEELGQRLQEQNELIITQRQQIKD 441
K+R +EL ++ +E+ EL + Q +++
Sbjct: 1159 --EKRRRQELERQYREEEELQQEEEQLLRE 1186
Score = 37.4 bits (85), Expect = 0.059
Identities = 45/208 (21%), Positives = 93/208 (44%), Gaps = 28/208 (13%)
Query: 157 EQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFL--Q 214
E+ ++ L +Q + K L+EE + R++ QQL H D+ F + L +
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQE-REQQLR----------HDRDRKFREEEQLLQE 1678
Query: 215 SHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEM 274
Q+ +E ++ Q+ + E L+EE QL R ELE +F +E ++
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER-------KFREEEQL 1731
Query: 275 QKTKEEDFLKLFDRWK----EEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQ 330
++ E++ L+ +R++ EE+ +E + ++ ++F+E E Q Q
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 331 KSNMQIKSNIGTLKDAHEFKEDRSPYPQ 358
+S+ + + + + +E++ PQ
Sbjct: 1792 ESDRKFREE----EQLRQEREEQQLRPQ 1815
Score = 37.0 bits (84), Expect = 0.077
Identities = 70/358 (19%), Positives = 139/358 (38%), Gaps = 34/358 (9%)
Query: 247 KEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKE 306
+EE +L + E + R +E E Q KEE+ + ++ EE EK + +E
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK---RRRQERE 1107
Query: 307 MFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQL 366
+E +EL + E QL ++ + + ++ E +++ QL
Sbjct: 1108 RQCREEEELQQE----EEQLLREEREKRRRQELERQYREEEEVQQEEE----------QL 1153
Query: 367 LDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQ 426
L + K R Q + +++++E+ + LR Y++ EEL ++ +
Sbjct: 1154 LREEPEK--RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE-EELQRQKR 1210
Query: 427 EQNELIITQRQQIK-DFTCNPLNSISEPKVNAPALHTLETK----SSLPMVHEQAFSSHI 481
+Q QR +K + N++ + KV + + S L Q H+
Sbjct: 1211 KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL 1270
Query: 482 LEPIEELSEEEKGRE---------NEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLME 532
L +E E++ R E++L + K S K L +
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330
Query: 533 KLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEK 590
+ ET + + ++ + L+ E +R +E E+ + Q R+FLE + + +E+
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Score = 34.3 bits (77), Expect = 0.50
Identities = 87/562 (15%), Positives = 213/562 (37%), Gaps = 76/562 (13%)
Query: 145 LEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCD 204
LE+RL+ H + + ++L ++ + + +R K I Q +E++A+ Q
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQAR------ERIKSRIPKWQWQLESEADARQ----- 716
Query: 205 KAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHAS 264
S + R ++ Q+ + + R + +EE + R + E
Sbjct: 717 ----------SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 265 AVRFSKEYEMQKTKEEDFLKLFDR---WKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSA 321
F+ +++ ++ E +L R ++ E++ +E ++ ++ F+ E +E +
Sbjct: 767 ---FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 322 LEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQ-- 379
+ E+Q ++ + + + A + +E+ +D ++ KW +++
Sbjct: 824 RREREKELQF--LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 380 ------------AIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQE 427
A+ ++ +KE+ L E+L+ + + R EE +LQ+
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE---QLQQ 938
Query: 428 QNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTL--ETKSSLPMVHEQAF--SSHILE 483
+ E ++ + ++ + + K+ L E + E+ + + +
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 484 PIEELSEEEKGRENEQK----------LNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEK 533
E+L EE+ + Q+ L + L + + L + R E+ +++
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 534 LETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALL 593
E + + +L R + E + ++E+ + + R E + C+ EE+
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 594 SSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKS 653
+Q + + E+ RQ ++ V + + + E+P R+
Sbjct: 1119 EEEQLLREEREKRRRQEL---------ERQYREEEEVQQEEEQL------LREEPEKRRR 1163
Query: 654 STITTPPFSSEE-EQEDDDLIR 674
+ EE +QE++ L+R
Sbjct: 1164 QELERQYREEEELQQEEEQLLR 1185
Score = 33.9 bits (76), Expect = 0.65
Identities = 63/291 (21%), Positives = 122/291 (41%), Gaps = 38/291 (13%)
Query: 122 RLAQFTIEYLLHSQE----FLTS--QLHTLEERLRLSHC-DGEQSKKLLTKQAGEIKTLK 174
+L Q E LH QE FL QL E +L H D + ++ Q GE + L+
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 175 EECKRRKKMISTQQLMIEAKANYY--QCHFCDKAFMNQAFLQSHIQRRHTEENS---HFE 229
+ + RK QQL + + + + + + + F + R+ TE+
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745
Query: 230 YQKNAQIEKLRSEIVVLK-------------EELQLTRSELEAAHHASAVRFSKEYEMQK 276
Y+K + E+LR E + E+L+ R E + S +F +E ++++
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 277 TKEEDFLKLFD-----RWKEEEKEKLVDEMEKVKE----MFMKEFKELTSKNSALEYQLS 327
+EE L+ RW EEE+ +L ++ +++++ + E + T + S E Q
Sbjct: 1806 EREEQQLRPQQRDGKYRW-EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 328 EIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARV 378
++ + + L++ H ++ + + H + + SQE K R+
Sbjct: 1865 WQEEEQKRRQERERKLREEHIRRQQKE---EQRHRQVGEIKSQEGKGHGRL 1912
Score = 33.5 bits (75), Expect = 0.85
Identities = 44/287 (15%), Positives = 120/287 (41%), Gaps = 10/287 (3%)
Query: 157 EQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSH 216
E+ ++ L +Q + K L+EE + R++ + E ++ + F ++ Q +
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE---EQQLHRQQ 1528
Query: 217 IQRRHTEENSHFEYQKNAQIEKL-RSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQ 275
QR+ +E Q+ Q + R +E+L+ R E + + +F E E +
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE-EQK 1587
Query: 276 KTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQ 335
++E K + ++ +++ ++ + ++ +E ++L + + E + ++
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647
Query: 336 IKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQE-----HKKEKG 390
+ + + + + DR ++ ++Q + Q+ + R + +E ++ +
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 391 RLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQ 437
+ L ++LR ++ ++ E+ R QE+ I+ + Q
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 58.5 bits (140), Expect = 2e-08
Identities = 82/452 (18%), Positives = 188/452 (41%), Gaps = 52/452 (11%)
Query: 169 EIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHI--QRRHTEENS 226
++K L + ++ ++M++ ++ +++ + + LQS + ++ +E
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAA---ENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 227 HFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLF 286
E + A+ E+LR+ + K+EL+ +LEA R +K +++ +L
Sbjct: 890 QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 287 DRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA 346
++ +EEE + ++EKV + K+L + LE Q ++ K
Sbjct: 950 EQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLAKEK------------- 994
Query: 347 HEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDD 406
+LL+ + +++T + ++EK + L+ ++ +MI D
Sbjct: 995 ------------------KLLEDRIAEFTTNL-----TEEEEKSKSLAKLKNKHEAMITD 1031
Query: 407 LNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETK 466
L +R E+ Q L++ + + D I+E K+ A E +
Sbjct: 1032 LEER----LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL-AKKEEELQ 1086
Query: 467 SSLPMVHEQAFSSHI-LEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTM 525
++L V E+A ++ L+ I EL E + E ++ L + + KA K L + L +
Sbjct: 1087 AALARVEEEAAQKNMALKKIREL--ESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144
Query: 526 VEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSC 585
+ L + L++ ++R +++ + K++E E E +I Q +++
Sbjct: 1145 -KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 586 KIEEKALLSSDQCSVSQMDTLSTGEVPKMIQL 617
++E+ + ++ Q GE+ +++
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Score = 52.0 bits (123), Expect = 2e-06
Identities = 92/531 (17%), Positives = 213/531 (40%), Gaps = 44/531 (8%)
Query: 143 HTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHF 202
H LE+++ H KK + G ++T +E ++ +K + E K Y
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412
Query: 203 CDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHH 262
K + Q + H +++ +K + ++L +E + + R EA
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE-- 1470
Query: 263 ASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSAL 322
+ KE L L +E ++K E+E++ + F E ++L S +
Sbjct: 1471 ------------AREKETKALSLARALEEAMEQKA--ELERLNKQFRTEMEDLMSSKDDV 1516
Query: 323 EYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQL-LDSQESKWTARVQAI 381
+ E++KS ++ + +K E ED +D +++ L + ++++ +Q
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 382 HQEHKKEKGRLLSHIEKLRTSMIDDLNASN--VFYKKRIE----ELGQRLQEQNELIITQ 435
++ +++K +L+ + ++ + D+ + V +K++E +L + N+
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 436 RQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGR 495
+Q++ + + E + + ++ ++ + +++ EEL+ E+ +
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 496 ENEQ--------KLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIR--G 545
Q ++ N+ AL+ L + + E+ E+ T IN ++
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 546 ISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDT 605
+ DQ++ L S H Q+ E R+ E +V + E + S + S++ ++
Sbjct: 1757 LQIDQINTDLNLERS--HAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEA 1814
Query: 606 LSTGEVPKMIQLPSK--NRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSS 654
K+ QL + N RQ A R + K+K +++ R+++
Sbjct: 1815 -------KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858
Score = 50.1 bits (118), Expect = 9e-06
Identities = 101/526 (19%), Positives = 208/526 (39%), Gaps = 93/526 (17%)
Query: 100 KLEDEKC----PHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLT---------SQLHTLE 146
KLE+E+ +C+ + LL+ R+A+FT ++ + + + LE
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLE-DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE 1033
Query: 147 ERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKA 206
ERLR ++ +K K G+ L ++ + I+ ++ + K
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK------------ 1081
Query: 207 FMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAV 266
+ LQ+ + R EE + + +I +L S+I L+E+L+ R+ A
Sbjct: 1082 ---EEELQAALAR--VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR- 1135
Query: 267 RFSKEYEMQKTKEEDFLKLFDRWKE--EEKEKLVDEMEKVKEMFMK----EFKELTSKNS 320
+E E KT+ ED L +E ++E+ V+ ++K E K + +E+ K+S
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 321 ALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESK------W 374
+L+E + ++K+N+ K E +R + ++Q E K
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLE--NERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 375 TARVQAIHQEHKKEKGRLLSHIEKLR------TSMIDDLNASNVFYKKRIEELGQRLQEQ 428
+Q E ++ + L + KL+ T ++ ++ + K L +LQ+
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 429 NELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEEL 488
EL+ + +Q L + L V ++ S E+L
Sbjct: 1314 QELLQEENRQ-----------------------KLSLSTKLKQVEDEKNSFR-----EQL 1345
Query: 489 SEEEKGRENEQK----LNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIR 544
EEE+ + N +K L+ ++K ++ + + V++ L + LE L + +
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE-VKRKLQKDLEGLSQRHEEK 1404
Query: 545 GISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEK 590
+ D+L + ++ E ++ + + Q +C +E+K
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDH--------QRQSACNLEKK 1442
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 58.5 bits (140), Expect = 2e-08
Identities = 105/523 (20%), Positives = 207/523 (39%), Gaps = 73/523 (13%)
Query: 140 SQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQ 199
++L +LEE R + DG+ +K+ L K G+IK L E+ R L E + +
Sbjct: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR---------LTYEIEDEKRR 1124
Query: 200 CHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEA 259
+ F Q +Q+ E + +Q KL SE + ++E ++ R +
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ------KLESEKAIKEKEYEIERLRVLL 1178
Query: 260 AHHASAVRFSKEYEMQKTK-EEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSK 318
+ R EYE + K + + + + + ++ +KE+ M+ KE SK
Sbjct: 1179 QEEGTRKR---EYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQ--KEDDSK 1233
Query: 319 NSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARV 378
N L QL + + N +K I L D+ +L + E + A
Sbjct: 1234 N--LRNQLDRLSRENRDLKDEIVRLNDS-------------------ILQATEQRRRAEE 1272
Query: 379 QAIHQEH-KKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELI----- 432
A+ Q+ E + H+E ++ + N +K+ +EE + +Q++N+ I
Sbjct: 1273 NALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA 1332
Query: 433 -----ITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEE 487
+R + ++ N+ E ++ E + +H+ ++ E+
Sbjct: 1333 EFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLT-----MQKEED 1387
Query: 488 LSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGIS 547
S +N + N + K LK+ + T VE+++ ++ T + +
Sbjct: 1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447
Query: 548 SDQLHRV--LKSVESERHKQ------------EREIPNFHQIREFLEHQVSCKIEEKALL 593
+L +V +++ ES R+KQ +EI Q+ + + C +E A L
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARL 1507
Query: 594 SSDQCSVSQMDTLSTGEVPKM-IQLPSKNRQLIRQKAVSTDRT 635
Q + + ++ +T + K+ +Q R I + VS +RT
Sbjct: 1508 QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Score = 50.1 bits (118), Expect = 9e-06
Identities = 112/535 (20%), Positives = 230/535 (42%), Gaps = 63/535 (11%)
Query: 139 TSQLHTLEERLRLSHCDGE---QSKKLLTKQAGEIKTLK-EECKRRKKMISTQQLMIEAK 194
T L +EE ++ G Q K+ L + ++ ++ EE R K+ + I+ K
Sbjct: 1420 TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDK 1479
Query: 195 ANYYQC--HFCDKAFMNQAFLQSHIQRRHTEENSHFEYQK-NAQIEKLRSEIVVLKEELQ 251
+ DK ++ L+ R + ++ QK N+ + +++ V ++EL
Sbjct: 1480 NKEIERLKQLIDKETNDRKCLEDENARL---QRVQYDLQKANSSATETINKLKVQEQELT 1536
Query: 252 LTRSELEAAHHASAV------RFS---KEYEMQKTKEEDFLKLFDRWKEEE---KEKLVD 299
R + E V RF KE ++QK K E+ L R E+ ++KL +
Sbjct: 1537 RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEE 1596
Query: 300 EMEKVKEMFMKEFKELTSKNSALEYQLSEIQK---SNMQIKSNI--GTLKDAHEFKEDRS 354
E+E ++ ++ ++T+ LE Q S ++K +++ + ++ G L++ +E+
Sbjct: 1597 ELEGMRRSLKEQAIKITNLTQQLE-QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELR 1655
Query: 355 PYPQDFHNVM-QLLDSQESKWTARVQAIH-QEHKKEKGRLLSH----IEKLRTSMIDDLN 408
+ + QLL QES A ++ H Q+ ++K R L+ IE+L+ S+ ++L
Sbjct: 1656 RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ-SLTENLT 1714
Query: 409 ASNVFYKKRIEEL-----------GQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNA 457
++ ++ + L + ++N I+ R Q++ L + +N
Sbjct: 1715 KEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL--QGLIND 1772
Query: 458 PALHTLETKSSLPMVHEQAF--SSHILEPIEELSEEEKGRENE----QKLNNNKMHLRKA 511
+ + +QA S+ I E + ++ + RE+ + L +K L++
Sbjct: 1773 LQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1832
Query: 512 LK--SNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREI 569
+ + T T V+Q L + + + + + + ++ +ESER K ERE
Sbjct: 1833 EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1892
Query: 570 PNFHQIREFLEHQVSCKIEEKA---LLSSDQCSVSQMDTLST---GEVPKMIQLP 618
+ E L+ ++ +IEE+ L S + + SQ++T + E+ K+ Q P
Sbjct: 1893 NSLRSEIERLQAEIK-RIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRP 1946
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/466 (19%), Positives = 195/466 (41%), Gaps = 58/466 (12%)
Query: 151 LSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHF-------- 202
L + E+ + ++ G IK E+ + R+K + + + + + N Q
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 203 -----CDKAFMNQAFLQSHIQRRHT--EENSHFEYQKNAQIEKLRSEIVVLK---EELQL 252
CD+ N+ L++ ++ + E+ + A+ KL E LK ++L+L
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 253 TRSELEAAHHASAVRFSK---------EYEMQKTKEEDFLK------LFDRWKEEEK--- 294
T +++E HA+ + E + TKE+ L+ L D EE+K
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 295 --------EKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA 346
E+ VD++E E K +L LE L Q+S M ++++ L++
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 347 HEFKE----DRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTS 402
+ KE ++ +D + L + + AR++ + +E + E+ + +EKLR+
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER-TARAKVEKLRSD 1140
Query: 403 MIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHT 462
+ +L +R+EE G Q E+ + + + + + + + A AL
Sbjct: 1141 LSRELEE----ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR- 1195
Query: 463 LETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGL 522
K V E L+ +++ E+EK E + +L++ ++ + +K+ ++L K
Sbjct: 1196 ---KKHADSVAELGEQIDNLQRVKQKLEKEKS-EFKLELDDVTSNMEQIIKAKANLEKVS 1251
Query: 523 RTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQERE 568
RT+ +Q +++ + ++ + ++ E R +E+E
Sbjct: 1252 RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKE 1297
Score = 53.9 bits (128), Expect = 6e-07
Identities = 86/395 (21%), Positives = 168/395 (42%), Gaps = 62/395 (15%)
Query: 173 LKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQK 232
L+E+ K+++ I+ Q IE + K NQA ++ EE E
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDE-QVLALQLQKKLKENQARIEE------LEEELEAERTA 1130
Query: 233 NAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKE- 291
A++EKLRS+ L EL+ LE A A++V + EM K +E +F K+ +E
Sbjct: 1131 RAKVEKLRSD---LSRELEEISERLEEAGGATSV----QIEMNKKREAEFQKMRRDLEEA 1183
Query: 292 -------------------EEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKS 332
E + +D +++VK+ KE E + + + +I K+
Sbjct: 1184 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 333 NMQIKSNIGTLKD-AHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGR 391
++ TL+D A+E++ ++L ++Q S Q + + E G
Sbjct: 1244 KANLEKVSRTLEDQANEYR-------------VKLEEAQRSLNDFTTQ--RAKLQTENGE 1288
Query: 392 LLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNEL--IITQRQQIKDFTCNPLNS 449
L +E+ + ++I L + Y +++E+L ++L+E+ + + Q C+ L
Sbjct: 1289 LARQLEE-KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE 1347
Query: 450 ISEPKVNAPA-LHTLETKSSLPMVH-EQAFSSHILEPIEELSEEEKGRENEQKLNNNKMH 507
E + A A L + +K++ + + + ++ EEL E +K + Q+L + +
Sbjct: 1348 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK--KLAQRLQDAEEA 1405
Query: 508 LRKALKSNSSLTKGLRTMVEQNLMEKLETLGINAD 542
+ SSL K + L ++E L ++ +
Sbjct: 1406 VEAVNAKCSSLEK-----TKHRLQNEIEDLMVDVE 1435
Score = 50.1 bits (118), Expect = 9e-06
Identities = 85/421 (20%), Positives = 178/421 (42%), Gaps = 53/421 (12%)
Query: 235 QIEKLRSEIVVLKEELQLTRSELEAA-HHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEE 293
++EK+R ++ V K ELQ E EA+ H + E + K E KL ++ +E E
Sbjct: 1527 ELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1586
Query: 294 K-----EKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQ-----------KSNMQIK 337
+ +++VD ++ + + E+ +E L+E++ ++ Q+K
Sbjct: 1587 QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1646
Query: 338 SNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQ-EHKKEKGRLLSHI 396
S LKD +D D + +++ + + A ++ + + E+ R L+
Sbjct: 1647 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1706
Query: 397 EKLRTS----MIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISE 452
E + TS ++ N S + KK++E +LQ + E + Q+ ++ +I++
Sbjct: 1707 ELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV---QECRNAEEKAKKAITD 1763
Query: 453 PKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEE---------EKGRENEQKLNN 503
+ A L + S+ H + ++ + I++L + G++ QKL
Sbjct: 1764 AAMMAEELKKEQDTSA----HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEA 1819
Query: 504 NKMHLRKAL----KSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISS-----DQLHRV 554
L L K N+ KG+R E+ + E T D + + D+L
Sbjct: 1820 RVRELEGELEAEQKRNAESVKGMRKS-ERRIKEL--TYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 555 LKSVESERHKQEREI-PNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPK 613
+K+ + + + E + N + R+ ++H++ + EE+A ++ Q + + + G K
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRK-VQHELD-EAEERADIAESQVNKLRAKSRDIGAKQK 1934
Query: 614 M 614
M
Sbjct: 1935 M 1935
Score = 31.6 bits (70), Expect = 3.2
Identities = 60/307 (19%), Positives = 128/307 (41%), Gaps = 50/307 (16%)
Query: 291 EEEKEKLVDEMEKVKEMFMK---EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAH 347
E+E + +E ++KE K KEL K +L + +++Q +Q+++ L DA
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQ---LQVQAEQDNLNDAE 904
Query: 348 EFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDL 407
E + Q N +QL A+V+ +++ + E +++
Sbjct: 905 ERCD------QLIKNKIQL--------EAKVKEMNERLEDE----------------EEM 934
Query: 408 NASNVFYKKRIEELGQRLQ---EQNELIITQRQQIKDFTCNPLNSISEPKVNAPAL--HT 462
NA K+++E+ L+ + EL + + ++ K T N + +++E +
Sbjct: 935 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 994
Query: 463 LETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGL 522
+ K +L H+QA +E + S + + EQ++++ + L + K L +
Sbjct: 995 TKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1054
Query: 523 RTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQ 582
R + + + + + D QL LK E + ++Q +I + + L Q
Sbjct: 1055 RKLEGDLKLTQESIMDLEND-----KLQLEEKLKKKEFDINQQNSKIED----EQVLALQ 1105
Query: 583 VSCKIEE 589
+ K++E
Sbjct: 1106 LQKKLKE 1112
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 58.2 bits (139), Expect = 3e-08
Identities = 117/499 (23%), Positives = 217/499 (43%), Gaps = 48/499 (9%)
Query: 78 DKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEF 137
D + G +D+++ Q + ++ L + ++ VL + L Q +E L S +
Sbjct: 1303 DLLLGKLDIISPQLSSASL----LTPQSAECLRASKSEVLSESSELLQQELEELRKSLQE 1358
Query: 138 LTSQLHTLEERL-RLSH---CDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEA 193
+ + TL+E RLS E +K + EIK LKE+ +K++ + L+I+A
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 194 KANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLT 253
K++ Q ++ F N+ ++ + R+ I KL+ E + E +
Sbjct: 1419 KSD--QLLSSNENFTNKV-NENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
Query: 254 RSELEAAHHASAVRFS-----KEYEMQKTKE-----EDFLKLFDRWKEEEKEKLVDEMEK 303
+E +A + ++FS KE+E KE E LK ++ K E +L++ ++
Sbjct: 1476 ETEYQALQETN-MKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1534
Query: 304 VKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNV 363
++E + +E AL+ + Q N +++ + L+D KE RS Q+ +
Sbjct: 1535 MQEKTVVFQQERDQVMLALKQK----QMENTALQNEVQRLRD----KEFRS--NQELERL 1584
Query: 364 MQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQ 423
L E +T A K + ++ EKL +S NAS+ + +
Sbjct: 1585 RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASH-----QASVQVE 1639
Query: 424 RLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLP--MVHEQAFSSHI 481
LQEQ ++ QR D T L S+S+ +V AL + L E+A S
Sbjct: 1640 SLQEQLNVVSKQR----DETALQL-SVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAE 1694
Query: 482 LEPIEELSEEEKGRENEQKLNNNKMHLRKAL-KSNSSLTKGLRTMVEQNLM-EKLETLGI 539
LE ++L E K +N + L + L++ L ++N++L R + ++ E++E L
Sbjct: 1695 LEKQKQLIAEWK--KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKR 1752
Query: 540 NADIRGISSDQLHRVLKSV 558
++R D + + L S+
Sbjct: 1753 QNELRQEMLDDVQKKLMSL 1771
Score = 50.4 bits (119), Expect = 7e-06
Identities = 124/570 (21%), Positives = 224/570 (39%), Gaps = 78/570 (13%)
Query: 89 LQENIMNITF-CKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEE 147
L EN+ + F K+E+EK L+ + +E L L+ + +T+ E
Sbjct: 664 LNENLKKVAFDVKMENEK-----------LVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712
Query: 148 RLRLSHCDGEQ----SKKLLTKQAGEI-KTLKEECKRRKKMISTQQLMIEAKANYYQCHF 202
L++ + E +KK L ++A + KT++E R S QL E Q
Sbjct: 713 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772
Query: 203 CDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHH 262
+ A + + Q + T++ ++ Q+ +L ++ + E+L+ S+L+
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
Query: 263 ASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSAL 322
+ K +++T EE L +EE L +E+E+++E ++ + A
Sbjct: 833 KYSQALRKNEILRQTIEEKDRSLGS--MKEENNHLQEELERLRE------EQSRTAPVAD 884
Query: 323 EYQLSEIQKSNMQIKSNIGTLKD--AHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQA 380
L + + ++ S + T+K+ E K + + MQLL S
Sbjct: 885 PKTLDSVTELASEV-SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL---------- 933
Query: 381 IHQEHKKEKGRLLSHIEKL---RTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQ 437
QE KKE E++ T + + + +K IE++ +L E+ + I T
Sbjct: 934 --QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNS 991
Query: 438 QIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGREN 497
I E KV + + K L +A + +++ I+E RE
Sbjct: 992 DI----------FQETKVQSLNIENGSEKHDL----SKAETERLVKGIKE-------REL 1030
Query: 498 EQKLNNNK-MHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQ----LH 552
E KL N K + L K + S G T + Q + LE ++A I S Q L
Sbjct: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ--QKDLEIQALHARISSTSHTQDVVYLQ 1088
Query: 553 RVLKSVESERHK-----QEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLS 607
+ L++ ER K E+ N H E+ + +E AL+ Q ++ T
Sbjct: 1089 QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKL-QDENKKLSTRF 1147
Query: 608 TGEVPKMIQLPSKN-RQLIRQKAVSTDRTS 636
M + +N ++IR+K + D S
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALS 1177
Score = 36.6 bits (83), Expect = 0.10
Identities = 112/572 (19%), Positives = 227/572 (39%), Gaps = 97/572 (16%)
Query: 163 LTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQC--HFCDKAFMNQAFLQSHIQRR 220
LTKQ ++ K+E + ++I + L I+A H D ++ Q LQ++ R
Sbjct: 1042 LTKQIDQLS--KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ-LQAYAMER 1098
Query: 221 H---------TEENSHFEYQ----------KNAQIEKLRSEIVVLKEELQLTRSEL--EA 259
T ENSH + + K A + KL+ E L + + ++ E
Sbjct: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET 1158
Query: 260 AHHASAVRFSKEYEMQKTKEEDFLKLF----------------DRWKE--EEKEKL---V 298
+ S + K+ E+ ++ L ++++E +E++KL V
Sbjct: 1159 IQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV 1218
Query: 299 DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQK-------SNMQIKSNIGTLKDAHEFKE 351
+ME+ K+ M + + +++ L+ +L ++Q +N +++ + L ++E E
Sbjct: 1219 KKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNE 1278
Query: 352 DR-----SPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDD 406
+ Q H++ QL ++++ ++ I + E LR S +
Sbjct: 1279 TKLKNFGQELAQVQHSIGQLCNTKDLL-LGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
Query: 407 LNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETK 466
L+ S+ ++ +EEL + LQE++ I T ++ + +SI+ A LE K
Sbjct: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLS----DSIA-------ATSELERK 1386
Query: 467 SSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKA-----LKSNSSLT-- 519
HEQ S I++L E++ + QKL K L KA L SN + T
Sbjct: 1387 E-----HEQTDSE-----IKQLKEKQ---DVLQKLLKEKDLLIKAKSDQLLSSNENFTNK 1433
Query: 520 ---KGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIR 576
L NL E++ L ++ ++++ + E+E + F +
Sbjct: 1434 VNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMM- 1492
Query: 577 EFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTS 636
E + C ++ L+ +Q + + + TGE+ +++ ++ D+
Sbjct: 1493 -LREKEFECHSMKEKALAFEQL-LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVM 1550
Query: 637 VPKIKKNVMEDPFPRKSSTITTPPFSSEEEQE 668
+ +K + + + F S +E E
Sbjct: 1551 LALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Score = 31.2 bits (69), Expect = 4.2
Identities = 83/441 (18%), Positives = 165/441 (37%), Gaps = 90/441 (20%)
Query: 212 FLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKE 271
F + + E + + +IE + + + E L+ ++LE H AS + +
Sbjct: 33 FTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEI----Q 88
Query: 272 YEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQK 331
+ Q T + L ++KE E L ++ AL+ QL ++Q
Sbjct: 89 IKQQSTSYRNQL--------QQKE--------------VEISHLKARQIALQDQLLKLQS 126
Query: 332 SNMQIKSNIG--TLKDAHEFKEDRSPYPQDFH--------------------NVMQLLDS 369
+ + S G + F S +P FH N + L+S
Sbjct: 127 AAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLES 186
Query: 370 QESKW-----TARVQAIHQEHKKEKGRLLSHIEKL---RTSMIDD----LNASNVFYKKR 417
+ W T++ Q + E +L + I++L R+ IDD ++ ++++
Sbjct: 187 EVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQK 246
Query: 418 IEELGQRLQEQ--------NELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSL 469
+ E+ +R +E+ EL +Q L+ I E + L + +S+
Sbjct: 247 LTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK 306
Query: 470 PMVHEQAFSSHILEPIEELSEEEKGRE----NEQKLNNNKMHLRKA---LKSNSSLTKGL 522
M + I + ++LS E R+ +++LN K + + LK S +
Sbjct: 307 KM---EQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPS 363
Query: 523 RTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQ 582
+ EK L +A + + +L + L E+E + + + +Q E
Sbjct: 364 AVKQSDTMTEKERILAQSASVEEVF--RLQQALSDAENEIMR----LSSLNQDNSLAEDN 417
Query: 583 VSCKI------EEKALLSSDQ 597
+ K+ +EK+LLS ++
Sbjct: 418 LKLKMRIEVLEKEKSLLSQEK 438
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 57.4 bits (137), Expect = 6e-08
Identities = 110/528 (20%), Positives = 197/528 (37%), Gaps = 101/528 (19%)
Query: 130 YLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQL 189
Y HS+ F+ +++ L+E L E+ KK EI +K+E R+ + Q
Sbjct: 429 YRSHSK-FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQT 487
Query: 190 MIEAKANYYQCHFCDKAFMNQ---------AFLQSHIQ--RRHTEENSHFEYQKNAQIEK 238
+E N + + + A LQ+ + R EE +K QI+
Sbjct: 488 KLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQD 547
Query: 239 LRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQ---KTKEEDFLKLFDRWKE---- 291
+ E E+ + L+ V K +Q + KE+ L +R K
Sbjct: 548 MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD 607
Query: 292 ---------------EEKEKLV---------DEMEKVKEM--FMKEFKELTSKNSALEYQ 325
EKE+ + DE EK +E+ + K+ K+L K S L+
Sbjct: 608 TTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGD 667
Query: 326 LSEIQKSNMQIKSNIGTLKDAHEFKEDR-----SPYPQDFHNVMQLLDSQESKWTARVQA 380
LSE + S + +K + +L + K+ R Q ++ ++SQ K A A
Sbjct: 668 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK-MESQLKK--AHEAA 724
Query: 381 IHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNE---LIITQRQ 437
+ E + H+E+ T D+ + + + +E L + E+N+ I +
Sbjct: 725 LEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER 784
Query: 438 QIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGREN 497
Q+KD ++ N +E K S M+ E+ R
Sbjct: 785 QVKD--------QNKKVANLKHKEQVEKKKSAQML-------------------EEARRR 817
Query: 498 EQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKS 557
E LN++ L+ +L+ + L E+ L E ++ + + VL
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEEL----EEALRESVQI-----------TAEREMVLAQ 862
Query: 558 VESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDT 605
ES R E+++ E ++ ++ KA LSS Q S+++ +T
Sbjct: 863 EESARTNAEKQVEELLMAMEKVKQELE---SMKAKLSSTQQSLAEKET 907
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 57.4 bits (137), Expect = 6e-08
Identities = 94/477 (19%), Positives = 198/477 (41%), Gaps = 78/477 (16%)
Query: 141 QLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQC 200
Q H LE + + +KL ++ EI L ++ +++ +S+ + ++ +
Sbjct: 607 QRHLLESKQEKMQ---QLREKLCQEEEEEILRLHQQ---KEQSLSSLRERLQKAIEEEEA 660
Query: 201 HFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAA 260
++ ++L++ +Q + ++ A ++KLR E L+ + + R+ LE
Sbjct: 661 RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREE---LESQQKAERASLEQK 717
Query: 261 HHASAVRFSKEYEMQKTKEEDFLKLF-DRWKEEEKEKLVDEMEKVKEMFMKEFK-ELTSK 318
+ + +E E + E+ L ++ ++ +E+L E ++ KE EL
Sbjct: 718 NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
Query: 319 NSALEYQLSEI------------QKSNMQIKSNIGTLKD-AHEFKEDRSPYPQDFHNVM- 364
S+LE + E+ QK Q++ +G ++ H+ + Y + +++
Sbjct: 778 CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
Query: 365 ---QLLDSQESKWTARVQAIHQ------------EHKKEKGRLLSHI----EKLRTSMID 405
Q ++ + + +++ HQ E +K++ LL H+ E+L+ +
Sbjct: 838 EKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHER 897
Query: 406 DLNASNVFYKKRIEELGQRLQEQ----NELIITQRQQIKDFTCN-PLNSISEPKVNAPAL 460
+L KR+E+L +R +EQ +L + + KD L + E
Sbjct: 898 ELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQ 957
Query: 461 HTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTK 520
L+ + + + E+A ++H ++L E +K HL L+SN L +
Sbjct: 958 QLLDVQRQVALKSEEATATH-----QQLEEAQK----------EHTHL---LQSNQQLRE 999
Query: 521 GLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIRE 577
L + + L KLE+ D+ S QL + S+E+E K++ H +RE
Sbjct: 1000 ILDELQARKL--KLES---QVDLLQAQSQQLQKHFSSLEAEAQKKQ------HLLRE 1045
>gi|30794488 kinesin family member 27 [Homo sapiens]
Length = 1401
Score = 57.4 bits (137), Expect = 6e-08
Identities = 93/455 (20%), Positives = 194/455 (42%), Gaps = 43/455 (9%)
Query: 125 QFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEE--CKRRKK 182
+ ++ L +S+ LT + E L ++ E K L K + K++ ++ K K
Sbjct: 706 ELNLQKLKNSERILTEAKQKMRE-LTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKL 764
Query: 183 MISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSE 242
+Q +E Q + ++ ++ +Q+ E++K KLR +
Sbjct: 765 EHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQK---------EFRKKMDAAKLRVQ 815
Query: 243 IVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEE-EKEKLVDEM 301
++ K++ + L + A + + K ++ ++L + +EE EK K +D +
Sbjct: 816 VLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQK---IQLQRKLREENEKRKQLDAV 872
Query: 302 EKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQI-KSNIGTLKDAHEFKEDRSPYPQDF 360
K + +KE + T + L+ + ++ N++ K + G++ + E + ++
Sbjct: 873 IKRDQQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEV 932
Query: 361 HNVM---QLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKR 417
V+ Q L+ E+ R + ++ + + SH+E + LN ++ R
Sbjct: 933 EKVLNQRQELEELEADLKKREAIVSKKEALLQEK--SHLENKKLRSSQALNTDSLKISTR 990
Query: 418 IEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKVNAPALHTLETKSSLPMVHEQAF 477
+ L Q L E+N Q++ T ISE +V + + V E+
Sbjct: 991 LNLLEQELSEKN-------VQLQTSTAEEKTKISE-QVEVLQKEKDQLQKRRHNVDEKLK 1042
Query: 478 SSHILEPIEE--LSEEEKGRENEQKL----NNNKMHLRKALKSN-SSLTKGLRTMVEQNL 530
+ +L P EE L + E+G E + N + + +K+L+++ +L++G E N+
Sbjct: 1043 NGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRG-----EANV 1097
Query: 531 MEKLETLGINADIRGISSDQLHRVLKSVESERHKQ 565
+EKL L +IR I ++V+ E+ER +Q
Sbjct: 1098 LEKLACLS-PVEIRTILFRYFNKVVNLREAERKQQ 1131
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 56.6 bits (135), Expect = 9e-08
Identities = 92/430 (21%), Positives = 181/430 (42%), Gaps = 70/430 (16%)
Query: 146 EERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDK 205
E+++R+ D E++K+ K G++K +E + QQL K ++ + +
Sbjct: 1041 EKKVRM---DLERAKR---KLEGDLKLTQESIMDLEN--DKQQLDERLKKKDFELNALNA 1092
Query: 206 AFMNQAFLQSHIQRR---------HTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSE 256
++ L S +Q++ EE E A++EKLRS+ L EL+
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSD---LSRELEEISER 1149
Query: 257 LEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKE--------------------EEKEK 296
LE A A++V + EM K +E +F K+ +E E +
Sbjct: 1150 LEEAGGATSV----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1205
Query: 297 LVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPY 356
+D +++VK+ KE E + + + +I K+ ++ TL+D + E RS
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED--QMNEHRSKA 1263
Query: 357 PQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKK 416
+ +V L SQ +K + E G L +++ + ++I L + Y +
Sbjct: 1264 EETQRSVND-LTSQRAKL-----------QTENGELSRQLDE-KEALISQLTRGKLTYTQ 1310
Query: 417 RIEELGQRLQEQNEL--IITQRQQIKDFTCNPLNSISEPKVNAPA-LHTLETKSSLPMVH 473
++E+L ++L+E+ + + Q C+ L E + A A L + +K++ +
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
Query: 474 -EQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLME 532
+ + ++ EEL E +K + Q+L + + SSL K + L
Sbjct: 1371 WRTKYETDAIQRTEELEEAKK--KLAQRLQEAEEAVEAVNAKCSSLEK-----TKHRLQN 1423
Query: 533 KLETLGINAD 542
++E L ++ +
Sbjct: 1424 EIEDLMVDVE 1433
Score = 45.8 bits (107), Expect = 2e-04
Identities = 68/325 (20%), Positives = 136/325 (41%), Gaps = 44/325 (13%)
Query: 235 QIEKLRSEIVVLKEELQLTRSELEAA-HHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEE 293
++EK+R ++ K ELQ E EA+ H + E + K E KL ++ +E E
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 294 KEK-----LVDEME-------KVKEMFMKEFKELTSKNSALEYQLSEIQK----SNMQIK 337
+ K +VD ++ + + ++ K++ + +E QLS + + Q+K
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Query: 338 SNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQ-EHKKEKGRLLSHI 396
S LKD +D D + +++ + + A ++ + + E+ R L+
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Query: 397 EKLRTS----MIDDLNASNVFYKKRIE-ELGQRLQEQNELIITQRQQIKDFTCNPLNSIS 451
E + TS ++ N S + KK+++ +L Q E E + Q+ ++ +I+
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV----QECRNAEEKAKKAIT 1760
Query: 452 EPKVNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEE---------EKGRENEQKLN 502
+ + A L + S+ H + ++ + I++L + G++ QKL
Sbjct: 1761 DAAMMAEELKKEQDTSA----HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1816
Query: 503 NNKMHLRKAL----KSNSSLTKGLR 523
L L K N+ KG+R
Sbjct: 1817 ARVRELENELEAEQKRNAESVKGMR 1841
Score = 41.6 bits (96), Expect = 0.003
Identities = 99/533 (18%), Positives = 209/533 (39%), Gaps = 68/533 (12%)
Query: 157 EQSKKLLTKQAGE----IKTLKEECKRRKK-----MISTQQLMIEAKANYYQCHFCDKAF 207
E++KK L ++ E ++ + +C +K + LM++ + + DK
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 208 MNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVR 267
N + + ++++ E S E + + L +E+ LK + + LE
Sbjct: 1447 RNFDKILAEWKQKYEESQSELESSQK-EARSLSTELFKLKNAYEESLEHLET-------- 1497
Query: 268 FSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTS----KNSALE 323
F +E K +E+ L ++ K + E+EKV++ E EL S ++LE
Sbjct: 1498 FKRE---NKNLQEEISDLTEQLGSSGKT--IHELEKVRKQLEAEKMELQSALEEAEASLE 1552
Query: 324 YQLSEIQKSNM---QIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQA 380
++ +I ++ + QIK+ I + E Q N ++++DS ++ A ++
Sbjct: 1553 HEEGKILRAQLEFNQIKAEI-----ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 381 IHQE---HKKEKGRL------LSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNEL 431
++ KK +G L LSH ++ + + K +L ++ ++L
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 432 -----IITQRQQIKDFTCNPLNSISEPKVNAPAL---HTLETKSSLPMVHEQAFS----- 478
I+ +R + L ++ E + L +ET + ++H Q S
Sbjct: 1668 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 479 -------SHILEPIEELSEE-EKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNL 530
S + +EE +E E +K + + + LK + L M ++N+
Sbjct: 1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-KKNM 1786
Query: 531 MEKLETLGINAD-IRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEE 589
+ ++ L D I+ + L+ +E+ + E E+ Q R + K E
Sbjct: 1787 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL-EAEQKRNAESVKGMRKSER 1845
Query: 590 KALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKK 642
+ + Q + + L ++ +QL K + ++A T++ K +K
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1898
Score = 33.5 bits (75), Expect = 0.85
Identities = 69/334 (20%), Positives = 138/334 (41%), Gaps = 67/334 (20%)
Query: 290 KEEEKEKLVDEMEKVKEMFMK---EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA 346
+E+E + +E ++KE K KEL K +L + +++Q +Q+++ L DA
Sbjct: 845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ---LQVQAEQDNLADA 901
Query: 347 HEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDD 406
E + Q N +QL A+V+ +++ + E ++
Sbjct: 902 EERCD------QLIKNKIQL--------EAKVKEMNERLEDE----------------EE 931
Query: 407 LNASNVFYKKRIEELGQRLQ---EQNELIITQRQQIKDFTCNPLNSISEPKVNAPAL--H 461
+NA K+++E+ L+ + EL + + ++ K T N + +++E +
Sbjct: 932 MNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 991
Query: 462 TLETKSSLPMVHEQAFSSHILEP-------------IEELSEEEKGRENEQKLNNNKMHL 508
+ K +L H+QA E +++ + E E E+K+ +
Sbjct: 992 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 509 RKALKSNSSLTKGLRTMVE---QNLMEKL-----ETLGINADIRGISS--DQLHRVLKSV 558
++ L+ + LT+ +E Q L E+L E +NA I + QL + LK +
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 559 ESERHKQEREIPNFHQIR---EFLEHQVSCKIEE 589
++ + E E+ R E L +S ++EE
Sbjct: 1112 QARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,729,191
Number of Sequences: 37866
Number of extensions: 1729154
Number of successful extensions: 16554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 1183
Number of HSP's that attempted gapping in prelim test: 11044
Number of HSP's gapped (non-prelim): 5570
length of query: 848
length of database: 18,247,518
effective HSP length: 111
effective length of query: 737
effective length of database: 14,044,392
effective search space: 10350716904
effective search space used: 10350716904
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.