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Search of human proteins with 7661864
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 1700 0.0
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 1696 0.0
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 264 2e-70
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 246 5e-65
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 246 5e-65
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 245 1e-64
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 245 1e-64
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 244 2e-64
gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 244 2e-64
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 244 2e-64
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 243 4e-64
gi|148235002 TBC1 domain family, member 26 [Homo sapiens] 178 2e-44
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 151 3e-36
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 147 5e-35
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 147 5e-35
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 142 1e-33
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 136 9e-32
gi|151108489 TBC1 domain family, member 28 [Homo sapiens] 127 6e-29
gi|239756750 PREDICTED: similar to TBC1 domain family, member 28... 126 7e-29
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 126 7e-29
gi|239756746 PREDICTED: TBC1 domain family, member 27 [Homo sapi... 126 9e-29
gi|239745731 PREDICTED: TBC1 domain family, member 27 [Homo sapi... 125 2e-28
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 125 2e-28
gi|239751241 PREDICTED: TBC1 domain family, member 27 [Homo sapi... 122 1e-27
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 122 1e-27
gi|239756926 PREDICTED: similar to TBC1 domain family, member 3 ... 121 3e-27
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 115 2e-25
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 110 4e-24
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 110 5e-24
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 107 3e-23
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 1700 bits (4402), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHN 60
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHN
Sbjct: 1 MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHN 60
Query: 61 VAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK 120
VAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK
Sbjct: 61 VAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK 120
Query: 121 EETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN 180
EETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN
Sbjct: 121 EETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN 180
Query: 181 TEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEK 240
TEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEK
Sbjct: 181 TEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEK 240
Query: 241 ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMS 300
ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMS
Sbjct: 241 ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMS 300
Query: 301 YTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPG 360
YTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPG
Sbjct: 301 YTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPG 360
Query: 361 KEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQS 420
KEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQS
Sbjct: 361 KEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQS 420
Query: 421 RTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIR 480
RTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIR
Sbjct: 421 RTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIR 480
Query: 481 KEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAE 540
KEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAE
Sbjct: 481 KEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAE 540
Query: 541 DGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVS 600
DGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVS
Sbjct: 541 DGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVS 600
Query: 601 NKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSP 660
NKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSP
Sbjct: 601 NKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSP 660
Query: 661 GTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNG 720
GTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNG
Sbjct: 661 GTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNG 720
Query: 721 KLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAV 780
KLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAV
Sbjct: 721 KLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAV 780
Query: 781 SVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL 828
SVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL
Sbjct: 781 SVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL 828
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 1696 bits (4392), Expect = 0.0
Identities = 826/827 (99%), Positives = 827/827 (100%)
Query: 2 NSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNV 61
+SDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNV
Sbjct: 19 DSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNV 78
Query: 62 AVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKE 121
AVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKE
Sbjct: 79 AVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKE 138
Query: 122 ETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNT 181
ETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNT
Sbjct: 139 ETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNT 198
Query: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI 241
EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI
Sbjct: 199 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI 258
Query: 242 LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY 301
LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY
Sbjct: 259 LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY 318
Query: 302 TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGK 361
TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGK
Sbjct: 319 TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGK 378
Query: 362 EDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSR 421
EDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSR
Sbjct: 379 EDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSR 438
Query: 422 TGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRK 481
TGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRK
Sbjct: 439 TGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRK 498
Query: 482 EFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAED 541
EFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAED
Sbjct: 499 EFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAED 558
Query: 542 GKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSN 601
GKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSN
Sbjct: 559 GKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSN 618
Query: 602 KFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSPG 661
KFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSPG
Sbjct: 619 KFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSPG 678
Query: 662 TQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGK 721
TQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGK
Sbjct: 679 TQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGK 738
Query: 722 LIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVS 781
LIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVS
Sbjct: 739 LIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVS 798
Query: 782 VDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL 828
VDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL
Sbjct: 799 VDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL 845
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 264 bits (675), Expect = 2e-70
Identities = 154/429 (35%), Positives = 221/429 (51%), Gaps = 16/429 (3%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEI 71
AQER +I+ KYD+G E + DRFG LHE ELP ++ E+
Sbjct: 12 AQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREM 71
Query: 72 ERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLK 131
RT+KW++ML WE YK++ K R+YKGIP+ +RG VW++LL I ++K + Y +K
Sbjct: 72 TRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMK 131
Query: 132 HRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ 191
R + S I IDLDV T R+H+ FRDRYG KQ+ LF++L AYS YN EVGYC+ +S
Sbjct: 132 ERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSH 191
Query: 192 ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 251
ITAL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K K
Sbjct: 192 ITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMW 251
Query: 252 HLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHL 311
H D + + ++ + +D L LR+WD+Y+ EGE+VL ++ LK+ +K L
Sbjct: 252 HQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRL 311
Query: 312 MKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLG 371
MK S L + + DD V++ L+ S +L R + DLP P K ++ P
Sbjct: 312 MKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPPAKREQGSLAP-- 369
Query: 372 QLPPELQSWGVHHLSNG------------QRSVGRPSPLASGRRESGAPHRRHEHSPHPQ 419
P S G L G QR + SP + R + P +P
Sbjct: 370 --RPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPV 427
Query: 420 SRTGTPERA 428
G P A
Sbjct: 428 GTQGVPSLA 436
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 246 bits (629), Expect = 5e-65
Identities = 150/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID DV+ T R HI FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R K DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKKGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 246 bits (629), Expect = 5e-65
Identities = 150/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID DV+ T R HI FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R K DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKKGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 245 bits (626), Expect = 1e-64
Identities = 148/434 (34%), Positives = 217/434 (50%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID D++ T R H+ FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ SK
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R + DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 245 bits (625), Expect = 1e-64
Identities = 149/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID DV+ T R HI FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R + DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 244 bits (624), Expect = 2e-64
Identities = 149/434 (34%), Positives = 215/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID DV+ T R HI FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R K DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKKGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
Length = 549
Score = 244 bits (624), Expect = 2e-64
Identities = 148/434 (34%), Positives = 216/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID D++ T R H+ FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y EEDAFWALV+L + +H++ GF + Q+ E ++ SK
Sbjct: 192 HIAALFLLYFPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R + DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 244 bits (623), Expect = 2e-64
Identities = 147/434 (33%), Positives = 217/434 (50%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G + E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHQAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID D++ T R H+ FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R + DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 243 bits (621), Expect = 4e-64
Identities = 147/434 (33%), Positives = 216/434 (49%), Gaps = 25/434 (5%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D G +HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+ ML WEKYK++ K R YKG+P+ +RG +W++LL I +MK + Y +
Sbjct: 72 ISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMS 190
K + + S I++ID D++ T R H+ FRDRYG KQ+ L H+L AY YN EVGYC+ +S
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 191 QITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLK 250
I AL L+Y+ EEDAFWALV+L + +H++ GF + Q+ E ++ K
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 251 QHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKH 310
H D +++ + + +D L LR+WD+Y+ EGE+ L ++ K+ +K
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 311 LMKLS----MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYP 366
L K S F +T A+D +D V++ L+ SM +L R + DLP P K P
Sbjct: 312 LTKTSRCGPWARFCNRFVDTWARD----EDTVLKHLRASMKKLTRKQGDLPPPAK----P 363
Query: 367 KKPLGQLPPELQSWGVHHLSNGQRSV--GRP----------SPLASGRRESGAPHRRHEH 414
++ P S G L G R G P SP + R + P
Sbjct: 364 EQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVRE 423
Query: 415 SPHPQSRTGTPERA 428
+P G P A
Sbjct: 424 DTYPVGTQGVPSPA 437
>gi|148235002 TBC1 domain family, member 26 [Homo sapiens]
Length = 250
Score = 178 bits (452), Expect = 2e-44
Identities = 92/205 (44%), Positives = 133/205 (64%), Gaps = 4/205 (1%)
Query: 18 IVAKYDRG-REGAEIE-PWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTT 75
I+ KY++G R GA ++ E D V K T+ G +HE ELP + +Q+ E +RT
Sbjct: 19 IITKYEQGHRAGAAVDLGHEQVD--VRKYTNNLGIVHEMELPRVSALEVKQRRKESKRTN 76
Query: 76 KWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRAR 135
KW KML W KY++T+K +R+YK IPL +RG W+LLL+I ++K + Y +K + +
Sbjct: 77 KWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKYKVMKEKGK 136
Query: 136 GCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITAL 195
S I I LDV+ T + H+MF R+GVKQQ L +L AYS YN EVGY + +S+ITA+
Sbjct: 137 RSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITAI 196
Query: 196 LLMYMNEEDAFWALVKLFSGPKHAM 220
LL+ + EEDAFWAL +L +G +H++
Sbjct: 197 LLLCLPEEDAFWALTQLLAGERHSL 221
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 151 bits (381), Expect = 3e-36
Identities = 93/291 (31%), Positives = 149/291 (51%), Gaps = 10/291 (3%)
Query: 68 HLEIERTTKWLKMLKGWE--KYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
HLE + W +++ WE + K ++ ++KGIP R VW LL M +D
Sbjct: 129 HLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMP--IKD 186
Query: 126 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 185
YS+L C IR+ D+ RT+ +H F+++ + Q+ LF+V+ AYS+ + EVGY
Sbjct: 187 QYSELLKMTSPCEKLIRR---DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGY 243
Query: 186 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 245
CQG + I LLLM M EE+AF VKL + + F +L E ++ +
Sbjct: 244 CQGSAFIVGLLLMQMPEEEAFCVFVKLMQ--DYRLRELFKPSMAELGLCMYQFECMIQEH 301
Query: 246 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
L +L H SQ +TS Y WF FL P + RI+DI++ EG ++ + +L+
Sbjct: 302 LPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQ 361
Query: 306 LHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIE-QLQISMTELKRAKLD 355
+++ LM+L ME +++ FQ+ + F D +I+ Q+ K KL+
Sbjct: 362 MNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLE 412
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 147 bits (370), Expect = 5e-35
Identities = 90/291 (30%), Positives = 148/291 (50%), Gaps = 10/291 (3%)
Query: 68 HLEIERTTKWLKMLKGWEKYKNTEK--FHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
HLE + W ++ WE+++ ++ I KGIP R VW LL M ++
Sbjct: 81 HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMP--VKN 138
Query: 126 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 185
YS+L + C IR+ D+ RT+ +H F+ + + Q+ LF+V+ AYS+ + EVGY
Sbjct: 139 QYSELLKMSSPCEKLIRR---DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
Query: 186 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 245
CQG + I LLLM M EE+AF V+L ++ + F +L E +L +
Sbjct: 196 CQGSAFIVGLLLMQMPEEEAFCVFVRLMQ--EYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
Query: 246 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
L L H SQ +TS Y WF FL P + R++DI+++EG ++ + +L+
Sbjct: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
Query: 306 LHKKHLMKLSMEELVEFFQETLAKDF-FFEDDFVIEQLQISMTELKRAKLD 355
+++ LM+L ME + ++FQ + F D V++ Q+ K +L+
Sbjct: 314 VNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLE 364
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 147 bits (370), Expect = 5e-35
Identities = 90/291 (30%), Positives = 148/291 (50%), Gaps = 10/291 (3%)
Query: 68 HLEIERTTKWLKMLKGWEKYKNTEK--FHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
HLE + W ++ WE+++ ++ I KGIP R VW LL M ++
Sbjct: 81 HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMP--VKN 138
Query: 126 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 185
YS+L + C IR+ D+ RT+ +H F+ + + Q+ LF+V+ AYS+ + EVGY
Sbjct: 139 QYSELLKMSSPCEKLIRR---DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
Query: 186 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 245
CQG + I LLLM M EE+AF V+L ++ + F +L E +L +
Sbjct: 196 CQGSAFIVGLLLMQMPEEEAFCVFVRLMQ--EYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
Query: 246 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
L L H SQ +TS Y WF FL P + R++DI+++EG ++ + +L+
Sbjct: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
Query: 306 LHKKHLMKLSMEELVEFFQETLAKDF-FFEDDFVIEQLQISMTELKRAKLD 355
+++ LM+L ME + ++FQ + F D V++ Q+ K +L+
Sbjct: 314 VNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLE 364
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 142 bits (359), Expect = 1e-33
Identities = 126/460 (27%), Positives = 204/460 (44%), Gaps = 58/460 (12%)
Query: 40 LVYKVTDRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKY--KNTEKFHR 95
L + TD++GFL + ++ ++E +++ +R KWL M W+K+ + +K
Sbjct: 299 LALRKTDKYGFLGGSQ---YSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKL 355
Query: 96 RIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDH 155
R KGIP LR + W L ++ E+ + +L+ RA G + I+ D++R F H
Sbjct: 356 RCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELE-RAPGDPKWLDVIEKDLHRQFPFH 414
Query: 156 IMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSG 215
MF R G QQ L+ +L AY+IY + GYCQ + + A+LLM+M E AFW LV++
Sbjct: 415 EMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD- 473
Query: 216 PKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDR 275
+ G++ G + E +L + +HL Q I Y +WF F
Sbjct: 474 --KYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFART 531
Query: 276 TPFTLNLRIWDIYIFEGERVLTAMSYTIL--------KLHKKHLMKLSMEELVEFFQETL 327
P+ LR+WD++ EG +++ ++ +L KL M +ME+L Q+ +
Sbjct: 532 LPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCM 591
Query: 328 AKDFFFED-------DFVIEQ---LQISMTELKRAKLDLPEPGK----------EDEYPK 367
+DF + + +IE+ Q+ R +L P + E +
Sbjct: 592 QEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQY-RPSRRLHGSRAIHEERRRQQ 650
Query: 368 KPLGQLPPELQSWGVHHLSNGQRSV-GRPSPLASGRRESGAP--------HRRHEHSPHP 418
PLG L G+ S G R+ G PSP RR S P H P P
Sbjct: 651 PPLGPSSSLLSLPGLK--SRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSP 708
Query: 419 QSRTGTP------ERAQPPRRKSVEEESKKLKDEADFQRK 452
+ TP R Q R+ E+E +K + E + +R+
Sbjct: 709 TGNS-TPLGSSKETRKQEKERQKQEKERQKQEKEREKERQ 747
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 136 bits (342), Expect = 9e-32
Identities = 122/427 (28%), Positives = 194/427 (45%), Gaps = 31/427 (7%)
Query: 46 DRFGFL-----HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKY--KNTEKFHRRIY 98
D+FGF+ E L + + V RQ R +KWL ML W+K+ K +K R
Sbjct: 56 DKFGFIVGSQGAEGALEEVPLEVLRQ------RESKWLDMLNNWDKWMAKKHKKIRLRCQ 109
Query: 99 KGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMF 158
KGIP LRG W L ++ + +L + G + I+ D++R F H MF
Sbjct: 110 KGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELD-MSPGDPKWLDVIERDLHRQFPFHEMF 168
Query: 159 RDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKH 218
R G QQ LF VL AY++Y E GYCQ + I A+LLM+M E AFW LV++ +
Sbjct: 169 VSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQIC---EK 225
Query: 219 AMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPF 278
+ G++ + + E +L K +HL Q+I Y +WF F P+
Sbjct: 226 YLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPW 285
Query: 279 TLNLRIWDIYIFEGERVLTAMSYTILK--LHKKHLMKL--SMEELVEFFQETLAKDFFFE 334
+ LR+WD++ EG +++ + +LK L +K E +E + +L+ E
Sbjct: 286 SSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLR-SLSPKIMQE 344
Query: 335 DDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLGQLPPELQ-SWGVHHLSNGQRSVG 393
V E +++ +TE + + L + + E + + PP L + + G R
Sbjct: 345 AFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPAL 404
Query: 394 RPSPLASGRRESGAPHRRHEHSPHPQSRTGTPERAQPPRRKSVEEESKKLKDEADFQRKL 453
+PSP S R AP + P P P++AQ +RK ++ + K A Q +
Sbjct: 405 QPSP--SIRLPLDAPLPGSKAKPKP------PKQAQKEQRKQMKGRGQLEKPPAPNQAMV 456
Query: 454 PSGPQDS 460
+ D+
Sbjct: 457 VAAAGDA 463
>gi|151108489 TBC1 domain family, member 28 [Homo sapiens]
Length = 210
Score = 127 bits (318), Expect = 6e-29
Identities = 75/183 (40%), Positives = 106/183 (57%), Gaps = 5/183 (2%)
Query: 1 MNSDQDVALKLAQERAEIV-AKYDRG-REGAEIE-PWEDADYLVYKVTDRFGFLHEEELP 57
M D+D AQ + I+ KY++G R GA ++ E D V K T+ G +HE ELP
Sbjct: 1 MEMDEDPDNLPAQGQGNIIITKYEQGHRAGAAVDLGHEQVD--VRKYTNNLGIVHEMELP 58
Query: 58 DHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIP 117
+ +Q+ E +RT KW KML W KY++T+K +R+ K IPL +RG +LLL+I
Sbjct: 59 RVSALEVKQRRKESKRTNKWQKMLADWTKYRSTKKLSQRVCKVIPLAVRGRALSLLLDID 118
Query: 118 KMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYS 177
K+K + Y +K + + S I I LDV+ T + H+MF R+GVKQQ L +L AYS
Sbjct: 119 KIKSQNPGKYKVMKEKGKRSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYS 178
Query: 178 IYN 180
YN
Sbjct: 179 AYN 181
>gi|239756750 PREDICTED: similar to TBC1 domain family, member 28
[Homo sapiens]
Length = 234
Score = 126 bits (317), Expect = 7e-29
Identities = 70/165 (42%), Positives = 99/165 (60%), Gaps = 4/165 (2%)
Query: 18 IVAKYDRG-REGAEIE-PWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTT 75
I+ KY++G R GA ++ E D V K T+ G +HE ELP + +Q+ E +RT
Sbjct: 43 IITKYEQGHRAGAAVDLGHEQVD--VRKYTNNLGIVHEMELPHVSALEVKQRRKESKRTN 100
Query: 76 KWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRAR 135
KW KML W KY++T+K +R+ K IPL +RG +LLL+I K+K + Y +K + +
Sbjct: 101 KWQKMLADWTKYRSTKKLSQRVCKVIPLAVRGRALSLLLDIDKIKSQNPGKYKVMKEKGK 160
Query: 136 GCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN 180
S I I LDV+ T + H+MF R+GVKQQ L +L AYS YN
Sbjct: 161 RSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYN 205
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 126 bits (317), Expect = 7e-29
Identities = 85/270 (31%), Positives = 128/270 (47%), Gaps = 14/270 (5%)
Query: 42 YKVTDRFGFL---HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKY--KNTEKFHRR 96
Y+ DR+GF+ E P H A L +R KW++M WEK + +K +
Sbjct: 34 YRQADRYGFIGGSSAEPGPGHPPA-----DLIRQREMKWVEMTSHWEKTMSRRYKKVKMQ 88
Query: 97 IYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHI 156
KGIP LR W LL ++ + Y +L A G + I D++R F H
Sbjct: 89 CRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDLHRQFPLHE 147
Query: 157 MFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGP 216
MF G QQ L VL AY++Y E GYCQ + A+LLM++ E+AFW LV++
Sbjct: 148 MFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQIC--- 204
Query: 217 KHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRT 276
+ + G++ + E +L + L + +HL + Y +WF F
Sbjct: 205 EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSL 264
Query: 277 PFTLNLRIWDIYIFEGERVLTAMSYTILKL 306
PF LR+WD ++ EG RVL + T+++L
Sbjct: 265 PFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
>gi|239756746 PREDICTED: TBC1 domain family, member 27 [Homo
sapiens]
Length = 339
Score = 126 bits (316), Expect = 9e-29
Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 25/283 (8%)
Query: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI 241
EVGY + +S+ TA+LL Y+ EEDAFW P A +L + H E++
Sbjct: 56 EVGYHRDLSRNTAVLL-YLPEEDAFWVAGSAAGRPNTA----------QLRKLLSHQEQV 104
Query: 242 LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY 301
L+K K+ + L + + + QCFLD F L LR+WD+ I EGE+VLTAM++
Sbjct: 105 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 164
Query: 302 TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGK 361
K+H++HLMKLS + E FQE L++ + ED+ V+ LQ SM EL + DLP
Sbjct: 165 ASFKIHREHLMKLSWSTVWE-FQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPS--- 220
Query: 362 EDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSP--LASGRRESGAPHRRHEHSPHPQ 419
P+ L +WG+ + R S A R ES H + +
Sbjct: 221 ----PESLLQNAHRCTIAWGLQSKAGKNSCTSRASGDFRAHPRTESLMXHLPAQKRRNKG 276
Query: 420 SRTGT---PERAQPPRRKSVEEESKKLKD-EADFQRKLPSGPQ 458
RT + E PP ++ +ES + D E F + P P+
Sbjct: 277 QRTASKSWKEMKYPPLGAAIGKESCPITDNELHFLERRPLSPK 319
>gi|239745731 PREDICTED: TBC1 domain family, member 27 [Homo
sapiens]
Length = 339
Score = 125 bits (314), Expect = 2e-28
Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 25/283 (8%)
Query: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI 241
EVGY + +S+ TA+LL Y+ EEDAFW P A +L + H E++
Sbjct: 56 EVGYHRDLSRNTAVLL-YLPEEDAFWVAGSAAGRPNTA----------QLRKLLSHQEQV 104
Query: 242 LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY 301
L+K K+ + L + + + QCFLD F L LR+WD+ I EGE+VLTAM++
Sbjct: 105 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 164
Query: 302 TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGK 361
K+H++HLMKLS + E FQE L++ + ED+ V+ LQ SM EL + DLP
Sbjct: 165 ASFKIHREHLMKLSWSTVWE-FQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPS--- 220
Query: 362 EDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSP--LASGRRESGAPHRRHEHSPHPQ 419
P+ L +WG+ + R S A R ES H + +
Sbjct: 221 ----PESLLQNAHCCTIAWGLQSKAGKNSCTSRASGDFRAHPRTESLMXHLPAQKRRNKG 276
Query: 420 SRTGT---PERAQPPRRKSVEEESKKLKD-EADFQRKLPSGPQ 458
RT + E PP ++ +ES + D E F + P P+
Sbjct: 277 QRTASKSWKEMKYPPLGVAIGKESCPITDNELHFLERRPLSPK 319
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 125 bits (313), Expect = 2e-28
Identities = 88/310 (28%), Positives = 146/310 (47%), Gaps = 19/310 (6%)
Query: 77 WLKMLKGWEKYKNT--EKFHRRIYKGIPLQLRGEVWALLLEIPK---MKEETRDLYSKLK 131
W ++L W N ++ + G+P LRGEVW LL + E+ R L +K
Sbjct: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE- 599
Query: 132 HRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ 191
SP I D+NRTF H F+D G Q SL+ + AYS+Y+ E+GYCQG S
Sbjct: 600 ------SPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSF 653
Query: 192 ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 251
+ A+LL++M EE AF LVK+ + + F Q F L E+++ +++ L
Sbjct: 654 LAAVLLLHMPEEQAFSVLVKIMF--DYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711
Query: 252 HLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHL 311
H + Y +WF F + P + I D+ + EG V+ ++ +LK K L
Sbjct: 712 HFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDL 771
Query: 312 MKLSMEELVEFFQETLAKDFFFEDDF-----VIEQLQISMTELKRAKLDLPEPGKEDEYP 366
+ E ++FF+ L K + E++ + ++IS +LK+ + + ++
Sbjct: 772 LLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQ 831
Query: 367 KKPLGQLPPE 376
+ P+ + E
Sbjct: 832 EDPIERFERE 841
>gi|239751241 PREDICTED: TBC1 domain family, member 27 [Homo
sapiens]
Length = 617
Score = 122 bits (307), Expect = 1e-27
Identities = 71/178 (39%), Positives = 101/178 (56%), Gaps = 12/178 (6%)
Query: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKI 241
EVGY + +S+ TA+LL Y+ EEDAFW P A +L + H E++
Sbjct: 186 EVGYHRDLSRNTAVLL-YLPEEDAFWVAGSAAGRPNTA----------QLRKLLSHQEQV 234
Query: 242 LNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSY 301
L+K K+ + L + + + QCFLD F L LR+WD+ I EGE+VLTAM++
Sbjct: 235 LHKSFPKIMRQLGKEGLCIEGSMLTRLLQCFLDGKSFGLTLRLWDVLILEGEQVLTAMAH 294
Query: 302 TILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEP 359
K+H++HLMKLS + E FQE L++ + ED+ V+ LQ SM EL + DLP P
Sbjct: 295 ASFKIHREHLMKLSWSTVWE-FQERLSQSWALEDNSVLRNLQTSMKELTKKHWDLPSP 351
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 122 bits (307), Expect = 1e-27
Identities = 85/274 (31%), Positives = 138/274 (50%), Gaps = 30/274 (10%)
Query: 72 ERTTKWLKMLK--GWEKYK-NTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK------EE 122
E TT W KML G K K + EK H + +G+P RGE+W L E +K ++
Sbjct: 769 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
Query: 123 TRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTE 182
+D+ K + + I +D+ RTF H F + G Q SL+++L AYS+ + E
Sbjct: 829 PKDV--PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQE 886
Query: 183 VGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPK-------LLRFQ 235
VGYCQG+S + +LL++M+EE+AF L L F G K +L+ Q
Sbjct: 887 VGYCQGLSFVAGILLLHMSEEEAFKMLKFL----------MFDMGLRKQYRPDMIILQIQ 936
Query: 236 EHH-EKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGER 294
+ ++L+ + L HL+ EI S Y WF F + P R++D+ +G
Sbjct: 937 MYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTE 996
Query: 295 VLTAMSYTILKLHKKHLMK-LSMEELVEFFQETL 327
V+ ++ ++L HK +++ ++E +V+F + TL
Sbjct: 997 VIFKVALSLLGSHKPLILQHENLETIVDFIKSTL 1030
>gi|239756926 PREDICTED: similar to TBC1 domain family, member 3
[Homo sapiens]
Length = 424
Score = 121 bits (303), Expect = 3e-27
Identities = 63/153 (41%), Positives = 88/153 (57%), Gaps = 1/153 (0%)
Query: 12 AQERAEIVAKYDRGREGAEIEPWEDADYLVYKVT-DRFGFLHEEELPDHNVAVERQKHLE 70
AQER +I+ KY++G E + Y D FG HE ELP +Q E
Sbjct: 12 AQEREDIIMKYEKGHRAGLPEDKGPKPFGSYNNNIDHFGMQHETELPPLTAREVKQIRRE 71
Query: 71 IERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKL 130
I R +KW+KML W+ YKN+ K R Y+GIP+ +RG +W++LL I ++K + Y +
Sbjct: 72 ISRKSKWVKMLGEWDTYKNSRKLIDRAYQGIPMNIRGPMWSVLLNIEEIKLKNPGRYQIM 131
Query: 131 KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYG 163
K + + S I+Q+DLDV+ T R HI FRDRYG
Sbjct: 132 KEKGKRSSEHIQQMDLDVSGTLRRHIFFRDRYG 164
Score = 31.2 bits (69), Expect = 4.1
Identities = 30/107 (28%), Positives = 41/107 (38%), Gaps = 16/107 (14%)
Query: 334 EDDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLGQLPPELQSWGVHHLSNGQRSV- 392
+DD V++ L+ SM +L R + DLP P K P++ P S G L G R
Sbjct: 210 DDDTVLKHLRASMKKLTRKQGDLPPPAK----PEQGSSASRPVPASRGGKTLCKGDRQAP 265
Query: 393 -GRP----------SPLASGRRESGAPHRRHEHSPHPQSRTGTPERA 428
G P SP + R + P +P G P A
Sbjct: 266 PGPPARFPWPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPA 312
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 115 bits (287), Expect = 2e-25
Identities = 72/243 (29%), Positives = 119/243 (48%), Gaps = 12/243 (4%)
Query: 97 IYKGIPLQLRGEVWALLL---EIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFR 153
+ G+P LR EVW LL + M + R L +K S I D++RTF
Sbjct: 535 VKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITK-------DSAQESVITRDIHRTFP 587
Query: 154 DHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLF 213
H F+D G Q+SL+ + AYS+Y+ ++GYCQG S + A+LL++M EE AF LVK+
Sbjct: 588 AHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIM 647
Query: 214 SGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFL 273
+ + + F L E+++ + L L H + Y +WF F
Sbjct: 648 Y--DYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFT 705
Query: 274 DRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFF 333
+ P + I D+ + EG ++ ++ +LK K+ L++ E ++FF+ L K +
Sbjct: 706 AKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRA 765
Query: 334 EDD 336
E++
Sbjct: 766 EEN 768
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 110 bits (276), Expect = 4e-24
Identities = 74/266 (27%), Positives = 123/266 (46%), Gaps = 23/266 (8%)
Query: 77 WL-KMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLL--EIPKMKEETRDLYSKLKHR 133
W+ ++L WE ++T + ++G+P +RG+VW+L + E+ E S+ K R
Sbjct: 460 WINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKER 519
Query: 134 ARGCSP-----------------DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAY 176
+ S + I LD++RTF +F+ + G L +L AY
Sbjct: 520 WKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQ-KGGPYHDVLHSILGAY 578
Query: 177 SIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQE 236
+ Y +VGY QGMS I A+L++ + E DAF A L + P FF +L++
Sbjct: 579 TCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKP--CQLAFFRVDHSMMLKYFA 636
Query: 237 HHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVL 296
E + LSKL H S + Y + W F + P L R+WD++ +GE L
Sbjct: 637 TFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFL 696
Query: 297 TAMSYTILKLHKKHLMKLSMEELVEF 322
IL+L++ L+++ + +F
Sbjct: 697 FRTGLGILRLYEDILLQMDFIHIAQF 722
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 110 bits (275), Expect = 5e-24
Identities = 79/265 (29%), Positives = 127/265 (47%), Gaps = 23/265 (8%)
Query: 91 EKFHRRIYKGIPLQLRGEVWALLL-------EIPKMKEETRDLYSKLKHRARGCSPDIRQ 143
E H + +G+P RGE+W L +P ++ Y +L + +
Sbjct: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKEL---LKQLTAQQHA 965
Query: 144 IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEE 203
I +D+ RTF H F + G Q SLF++L AYS+ + EVGYCQG+S + +LL++M+EE
Sbjct: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
Query: 204 DAFWALVKLFSGPKHAMH--GFFVQGFPKLLRFQ---EHHEKILNKFLSKLKQHLDSQEI 258
AF L K M+ GF Q P ++ Q ++L+ + L HL+ EI
Sbjct: 1026 QAFEML-------KFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078
Query: 259 YTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL-SME 317
S Y WF F + R++DI +G V+ ++ ++L + +M+ S E
Sbjct: 1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFE 1138
Query: 318 ELVEFFQETLAKDFFFEDDFVIEQL 342
+VEF + TL E + +I Q+
Sbjct: 1139 NIVEFLKNTLPDMNTSEMEKIITQV 1163
Score = 31.2 bits (69), Expect = 4.1
Identities = 56/255 (21%), Positives = 92/255 (36%), Gaps = 35/255 (13%)
Query: 426 ERAQPPRRKSVEEE---SKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRKE 482
E PPR K V + S ++AD ++ S ++ N +K
Sbjct: 469 EGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKT 528
Query: 483 FVPKWNKPSDVSATERTAKYTMEGKGRA------AHPALAVTVPGPAEVRVSNVRPKMKA 536
V PS +S + T G+ + A +L ++ + +R ++ +
Sbjct: 529 HVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGS 588
Query: 537 LDAEDGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSP 596
+D+ + + S AS+ D PG DS A SP + + P E S SP
Sbjct: 589 VDSFE-RSNSLASEKDYSPG---DSPPGTPPA-------SPPSSAWQTFPE---EDSDSP 634
Query: 597 SKVSNKFTFKVQPPSHARYPSQLDGEARGLAHP------------PSYSNPPVYHGNSPK 644
TF P S R + DG A+G+ P S NS
Sbjct: 635 QFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSS 694
Query: 645 HFPTANSSFASPQFS 659
P+ ++SF++P F+
Sbjct: 695 SLPSLHTSFSAPSFT 709
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 107 bits (268), Expect = 3e-23
Identities = 80/295 (27%), Positives = 140/295 (47%), Gaps = 12/295 (4%)
Query: 46 DRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPL 103
D +GF E+ D +L R KW ++L+G + R + KG+PL
Sbjct: 13 DPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG-VPRSRTVKRYVRKGVPL 71
Query: 104 QLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQ-IDLDVNRTFRDHIMFRDRY 162
+ R VW +L ++ Y +L R +P + I D+NRTF D++ FR
Sbjct: 72 EHRARVWMVLSGAQAQMDQNPGYYHQLLQGER--NPRLEDAIRTDLNRTFPDNVKFRKTT 129
Query: 163 G-VKQQSLFHVLAAYSIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKLFSGPKHAM 220
Q++L++VL AY +N VGYCQGM+ I L+L+ NEE++FW L L +
Sbjct: 130 DPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG---RIL 186
Query: 221 HGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTL 280
++ L QE +++ L + ++ + + +WF F+D P
Sbjct: 187 PDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVET 246
Query: 281 NLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK-LSMEELVEFFQETLAKDFFFE 334
LRIWD EG +++ ++ T++K H++ +++ S+ ++ + F++ F E
Sbjct: 247 VLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVME 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,619,014
Number of Sequences: 37866
Number of extensions: 2099714
Number of successful extensions: 8670
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 379
Number of HSP's that attempted gapping in prelim test: 7730
Number of HSP's gapped (non-prelim): 1122
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.