Search of human proteins with 7657307

Search of human proteins with 7657307

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657307 LIM domains containing 1 [Homo sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657307 LIM domains containing 1 [Homo sapiens]                   1423   0.0  
gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens]         384   e-106
gi|14249622 ajuba isoform 1 [Homo sapiens]                            332   7e-91
gi|5031887 LIM domain containing preferred translocation partner...   241   2e-63
gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]     223   4e-58
gi|58530845 zyxin [Homo sapiens]                                      214   2e-55
gi|4508047 zyxin [Homo sapiens]                                       214   2e-55
gi|37675280 ajuba isoform 2 [Homo sapiens]                            196   5e-50
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]    184   2e-46
gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]    176   6e-44
gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens]    117   3e-26
gi|170932516 paxillin isoform 2 [Homo sapiens]                        107   4e-23
gi|170932518 paxillin isoform 3 [Homo sapiens]                        104   3e-22
gi|170932514 paxillin isoform 1 [Homo sapiens]                        100   3e-21
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ...    97   6e-20
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              96   8e-20
gi|109638745 transforming growth factor beta 1 induced transcrip...    96   8e-20
gi|21361591 transforming growth factor beta 1 induced transcript...    96   8e-20
gi|221316659 leupaxin isoform 1 [Homo sapiens]                         96   1e-19
gi|4758670 leupaxin isoform 2 [Homo sapiens]                           96   1e-19
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]             95   2e-19
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo...    92   2e-18
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo...    92   2e-18
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo...    92   2e-18
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor...    92   2e-18
gi|239741720 PREDICTED: hypothetical protein XP_002342298 [Homo ...    89   1e-17
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]    85   2e-16
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]    85   2e-16
gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]    85   2e-16
gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]    85   2e-16

>gi|7657307 LIM domains containing 1 [Homo sapiens]
          Length = 676

 Score = 1423 bits (3684), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQ 60
           MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQ
Sbjct: 1   MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQ 60

Query: 61  QQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGAAKPPLAASTGAPGAVTTL 120
           QQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGAAKPPLAASTGAPGAVTTL
Sbjct: 61  QQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGAAKPPLAASTGAPGAVTTL 120

Query: 121 AAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCLTHGDYY 180
           AAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCLTHGDYY
Sbjct: 121 AAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCLTHGDYY 180

Query: 181 DNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSSSRSS 240
           DNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSSSRSS
Sbjct: 181 DNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSSSRSS 240

Query: 241 EGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAP 300
           EGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAP
Sbjct: 241 EGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAP 300

Query: 301 LALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGS 360
           LALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGS
Sbjct: 301 LALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGS 360

Query: 361 QQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLD 420
           QQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLD
Sbjct: 361 QQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLD 420

Query: 421 SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVF 480
           SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVF
Sbjct: 421 SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVF 480

Query: 481 GAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLC 540
           GAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLC
Sbjct: 481 GAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLC 540

Query: 541 GHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAAC 600
           GHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAAC
Sbjct: 541 GHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAAC 600

Query: 601 GLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVK 660
           GLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVK
Sbjct: 601 GLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVK 660

Query: 661 RLEKRPSSTALHQHHF 676
           RLEKRPSSTALHQHHF
Sbjct: 661 RLEKRPSSTALHQHHF 676


>gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens]
          Length = 430

 Score =  384 bits (987), Expect = e-106
 Identities = 202/413 (48%), Positives = 246/413 (59%), Gaps = 29/413 (7%)

Query: 269 QRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGV--M 326
           + + PG  SP      P  GP     P+              L R   G GG  +G   +
Sbjct: 21  RELEPGCGSPGRGRRGPRPGPGDEAAPA--------------LGRRGKGSGGPEAGADGL 66

Query: 327 SKPNVDPQ----PWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLG-------PKPGCT 375
           S+    P+    P     P     +S   S   G  GS + +   LG       P+ G +
Sbjct: 67  SRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRS 126

Query: 376 DLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLD-SPSSPR-VRLPCQP 433
           D   GP           +S+L           +   G+  +      P+ P    LP  P
Sbjct: 127 DPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALP 186

Query: 434 LVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLY 493
           L PG E  PSAAE +LEALT+ LER ++A    DYFG C+KC  G++GA QACQAMG+LY
Sbjct: 187 LPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLY 246

Query: 494 HDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALG 553
           H  CFTC +C R+LRGKAFY V  KV+C+EDFLYSGFQQ+AD+C +CGHLIM+MILQALG
Sbjct: 247 HTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALG 306

Query: 554 KSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDET 613
           KSYHPGCFRC +CNECLDGVPFTVD EN IYCVRDYH V APKCA+C  PILP +G + T
Sbjct: 307 KSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETT 366

Query: 614 IRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKRP 666
           IRVVSMDRDYHV CYHCEDCGL+L+ E+G RCYPL  HL C  CH++RL+  P
Sbjct: 367 IRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGP 419


>gi|14249622 ajuba isoform 1 [Homo sapiens]
          Length = 538

 Score =  332 bits (851), Expect = 7e-91
 Identities = 183/439 (41%), Positives = 245/439 (55%), Gaps = 48/439 (10%)

Query: 235 SSSRSSEGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPA-VGPVQPR 293
           S   S  GSL    +G GG    +P        S R S      +  +G+P   GP    
Sbjct: 133 SKPSSPRGSLLLDGAGAGGAGGSRPC-------SNRTSGISMGYDQRHGSPLPAGPCLFG 185

Query: 294 TPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSK--PNVDPQPWFQDGPKSYLSSSAPS 351
            P   AP   S    GG+P +   L   +  + ++       Q      P +  S  A +
Sbjct: 186 PPLAGAPAGYS---PGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGSPGALA 242

Query: 352 SSPAGLDG--SQQGAVPGLGPKPGCTDLGTGPKLSP--TSLVHPVMSTLP-ELSCKEGPL 406
            +  G  G   ++GA PG     G  D   G +     T+L+   + T   E   +  P 
Sbjct: 243 GAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPS 302

Query: 407 GWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKA 466
           G    G      L+ P  P V              P AA  ++        RE +A  + 
Sbjct: 303 GIEPSG------LEEPPGPFV--------------PEAARARM--------REPEA--RE 332

Query: 467 DYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFL 526
           DYFG C+KC+KG++G   ACQA+ +LYH  CF C +C R LR KAFY VNG V+CEED+L
Sbjct: 333 DYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYL 392

Query: 527 YSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCV 586
           +SGFQ++A++C +CGHLI++ ILQA+GKSYHPGCFRC++CN+CLDG+PFTVD  N++YCV
Sbjct: 393 FSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCV 452

Query: 587 RDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCY 646
            DYHK  APKCAACG PILP EG ++ +RV+SMDRDYH ECYHCEDC ++L+DE+G  C+
Sbjct: 453 TDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCF 512

Query: 647 PLEDHLFCHSCHVKRLEKR 665
           PL+ HL CH CH++RL  R
Sbjct: 513 PLDGHLLCHGCHMQRLNAR 531


>gi|5031887 LIM domain containing preferred translocation partner in
           lipoma [Homo sapiens]
          Length = 612

 Score =  241 bits (615), Expect = 2e-63
 Identities = 145/416 (34%), Positives = 207/416 (49%), Gaps = 61/416 (14%)

Query: 270 RVSPGLPSPNLENGAPAVGPVQPRTP----SVSAPLALSCPRQGGLPRSNSGLGGEVSGV 325
           +V    PSP+    AP+ G +    P    +   P++  CP         S  GG     
Sbjct: 224 QVKSAQPSPHYM-AAPSSGQIYGSGPQGYNTQPVPVSGQCPPP-------STRGGMDYAY 275

Query: 326 MSKPNVDPQPWFQDGPKS---YLSSSAPSSSPAGLDGS-----QQGAVPGLGPKPGCTDL 377
           +  P + P+P +   P     Y    A      G + S     QQG       +PG T  
Sbjct: 276 IPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPP 335

Query: 378 GTGPKLSP----------TSLVHPVMSTL-PELSCKEGPLGWSSDGSLGSVLLDSPSSPR 426
           G G +  P          T +  PV +   P L  K G       G LG      PSS  
Sbjct: 336 GAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGG-----HSGQLG------PSSV- 383

Query: 427 VRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQAC 486
                      P  RP   E +LE LT+++  +M+  P  +YFG C +C + V G G  C
Sbjct: 384 ----------APSFRP---EDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGC 430

Query: 487 QAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMD 546
            AM  ++H  CFTC  C+ KLRG+ FY V  K +CE  ++      + ++C +C   IM+
Sbjct: 431 TAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI-----NTLEQCNVCSKPIME 485

Query: 547 MILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILP 606
            IL+A GK+YHP CF CV+C+  LDG+PFTVD+   I+C+ D+HK  AP+C+ C  PI+P
Sbjct: 486 RILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMP 545

Query: 607 PEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRL 662
             G +ET+R+V++DRD+HV CY CEDCG  L++ D   CYPL+ H+ C +C+  R+
Sbjct: 546 APGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARI 601



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 21/94 (22%)

Query: 596 KCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCH 655
           +CA CG  ++  EG+  T    +MD+ +HV+C+ C  C  +L    G   Y +E   +C 
Sbjct: 415 RCARCGENVVG-EGTGCT----AMDQVFHVDCFTCIICNNKLR---GQPFYAVEKKAYCE 466

Query: 656 SCHVKRLEK-------------RPSSTALHQHHF 676
            C++  LE+             R +  A H H F
Sbjct: 467 PCYINTLEQCNVCSKPIMERILRATGKAYHPHCF 500


>gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]
          Length = 476

 Score =  223 bits (568), Expect = 4e-58
 Identities = 119/357 (33%), Positives = 182/357 (50%), Gaps = 46/357 (12%)

Query: 328 KPN----VDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKL 383
           KPN    +   P+    P SY ++S P+     +       V G GP        +GP  
Sbjct: 137 KPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLP 196

Query: 384 SP---------------TSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVR 428
            P                S   P      E +   GP G    G  G         P+V 
Sbjct: 197 GPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHG---------PQVP 247

Query: 429 LPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQA 488
           L   P            E +L+ LT++L  +M+  P  +YFG C  C + V G G    A
Sbjct: 248 LSQPP------------EDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVA 295

Query: 489 MGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMI 548
           +  ++H  CF C+ C  +LRG+ FY V  + +CE  ++      + ++C  C   I+D I
Sbjct: 296 LDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYV-----ATLEKCATCSQPILDRI 350

Query: 549 LQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPE 608
           L+A+GK+YHPGCF CV+C+  LDG+PFTVD+ ++I+C+ D+H+  AP+C+ CG  I+P  
Sbjct: 351 LRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEP 410

Query: 609 GSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCYPLEDHLFCHSCHVKRLEK 664
           G +ET+R+V++DR +H+ CY CE+CGL L+ E +   CYPL+ H+ C +C   R+++
Sbjct: 411 GQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQE 467


>gi|58530845 zyxin [Homo sapiens]
          Length = 572

 Score =  214 bits (546), Expect = 2e-55
 Identities = 137/416 (32%), Positives = 199/416 (47%), Gaps = 51/416 (12%)

Query: 259 PTGLWSTASSQRVSPGLPSPNLENGAPAVGP-------VQPRTPSVSAPLALSCPRQGGL 311
           P   W + SS +  P +P+P        V P       VQ    S + P++L+  +  G 
Sbjct: 196 PLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGP 255

Query: 312 PRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPK 371
           P S+     + S V   P   P         S  S  AP  S     GSQ     G    
Sbjct: 256 PASSPAPAPKFSPVT--PKFTPVA-------SKFSPGAPGGS-----GSQPNQKLG---H 298

Query: 372 PGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPC 431
           P     GTG    P S  +      P +  K+ P+               P +       
Sbjct: 299 PEALSAGTGSP-QPPSFTYAQQREKPRVQEKQHPV--------------PPPAQNQNQVR 343

Query: 432 QPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGA---CVKCSKGVFGAGQACQA 488
            P  PGP       EL  E LTQ+L ++M+ HP+         C +C + +  A  A +A
Sbjct: 344 SPGAPGPLTLKEVEEL--EQLTQQLMQDME-HPQRQNVAVNELCGRCHQPLARAQPAVRA 400

Query: 489 MGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMI 548
           +G L+H  CFTC  C+++L+G+ FY + G  +CE       +  + ++C  CG  I D +
Sbjct: 401 LGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCE-----GCYTDTLEKCNTCGEPITDRM 455

Query: 549 LQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPE 608
           L+A GK+YHP CF CV+C   L+G  F VD  N+ +CV DYHK  AP+C+ C  PI+P  
Sbjct: 456 LRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEP 515

Query: 609 GSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCYPLEDHLFCHSCHVKRLE 663
           G DET+RVV++D+++H++CY CEDCG  L+ E D + C+PL+ H+ C  CH  R +
Sbjct: 516 GRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 23/93 (24%), Positives = 37/93 (39%), Gaps = 21/93 (22%)

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHS 656
           C  C  P+   + +     V ++ + +H+ C+ C  C  +L    G + Y LE   +C  
Sbjct: 384 CGRCHQPLARAQPA-----VRALGQLFHIACFTCHQCAQQLQ---GQQFYSLEGAPYCEG 435

Query: 657 CHVKRLEK-------------RPSSTALHQHHF 676
           C+   LEK             R +  A H H F
Sbjct: 436 CYTDTLEKCNTCGEPITDRMLRATGKAYHPHCF 468



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 64/277 (23%), Positives = 87/277 (31%), Gaps = 70/277 (25%)

Query: 65  LQEETLPRGSRGPVNGGGRLGP-----QARWEVVGSKLTVD------------------- 100
           L+EE  P     P   GG   P     Q R +V    L +D                   
Sbjct: 109 LEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARV 168

Query: 101 --GAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSE 158
             G   PP+A    +  +    A G  P PP +  S          SQ      + A S+
Sbjct: 169 SSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPS---------SSQPLPQVPAPAQSQ 219

Query: 159 MSAFHQPGPCEDPSCLTH-GDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPP 217
                QP P   P    H       +SLA+ +    P  SP+           +P   P 
Sbjct: 220 TQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPA----------PAPKFSPV 269

Query: 218 LPKPCGDHPLNHRQLSLSSSRSSEGSLGGQ----NSGIG-------GRSSEKPTGLWSTA 266
            PK            +  +S+ S G+ GG     N  +G       G  S +P     T 
Sbjct: 270 TPK-----------FTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSF--TY 316

Query: 267 SSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLAL 303
           + QR  P +         PA    Q R+P    PL L
Sbjct: 317 AQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTL 353


>gi|4508047 zyxin [Homo sapiens]
          Length = 572

 Score =  214 bits (546), Expect = 2e-55
 Identities = 137/416 (32%), Positives = 199/416 (47%), Gaps = 51/416 (12%)

Query: 259 PTGLWSTASSQRVSPGLPSPNLENGAPAVGP-------VQPRTPSVSAPLALSCPRQGGL 311
           P   W + SS +  P +P+P        V P       VQ    S + P++L+  +  G 
Sbjct: 196 PLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGP 255

Query: 312 PRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPK 371
           P S+     + S V   P   P         S  S  AP  S     GSQ     G    
Sbjct: 256 PASSPAPAPKFSPVT--PKFTPVA-------SKFSPGAPGGS-----GSQPNQKLG---H 298

Query: 372 PGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPC 431
           P     GTG    P S  +      P +  K+ P+               P +       
Sbjct: 299 PEALSAGTGSP-QPPSFTYAQQREKPRVQEKQHPV--------------PPPAQNQNQVR 343

Query: 432 QPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGA---CVKCSKGVFGAGQACQA 488
            P  PGP       EL  E LTQ+L ++M+ HP+         C +C + +  A  A +A
Sbjct: 344 SPGAPGPLTLKEVEEL--EQLTQQLMQDME-HPQRQNVAVNELCGRCHQPLARAQPAVRA 400

Query: 489 MGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMI 548
           +G L+H  CFTC  C+++L+G+ FY + G  +CE       +  + ++C  CG  I D +
Sbjct: 401 LGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCE-----GCYTDTLEKCNTCGEPITDRM 455

Query: 549 LQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPE 608
           L+A GK+YHP CF CV+C   L+G  F VD  N+ +CV DYHK  AP+C+ C  PI+P  
Sbjct: 456 LRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEP 515

Query: 609 GSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCYPLEDHLFCHSCHVKRLE 663
           G DET+RVV++D+++H++CY CEDCG  L+ E D + C+PL+ H+ C  CH  R +
Sbjct: 516 GRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 23/93 (24%), Positives = 37/93 (39%), Gaps = 21/93 (22%)

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHS 656
           C  C  P+   + +     V ++ + +H+ C+ C  C  +L    G + Y LE   +C  
Sbjct: 384 CGRCHQPLARAQPA-----VRALGQLFHIACFTCHQCAQQLQ---GQQFYSLEGAPYCEG 435

Query: 657 CHVKRLEK-------------RPSSTALHQHHF 676
           C+   LEK             R +  A H H F
Sbjct: 436 CYTDTLEKCNTCGEPITDRMLRATGKAYHPHCF 468



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 64/277 (23%), Positives = 87/277 (31%), Gaps = 70/277 (25%)

Query: 65  LQEETLPRGSRGPVNGGGRLGP-----QARWEVVGSKLTVD------------------- 100
           L+EE  P     P   GG   P     Q R +V    L +D                   
Sbjct: 109 LEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARV 168

Query: 101 --GAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSE 158
             G   PP+A    +  +    A G  P PP +  S          SQ      + A S+
Sbjct: 169 SSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPS---------SSQPLPQVPAPAQSQ 219

Query: 159 MSAFHQPGPCEDPSCLTH-GDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPP 217
                QP P   P    H       +SLA+ +    P  SP+           +P   P 
Sbjct: 220 TQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPA----------PAPKFSPV 269

Query: 218 LPKPCGDHPLNHRQLSLSSSRSSEGSLGGQ----NSGIG-------GRSSEKPTGLWSTA 266
            PK            +  +S+ S G+ GG     N  +G       G  S +P     T 
Sbjct: 270 TPK-----------FTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSF--TY 316

Query: 267 SSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLAL 303
           + QR  P +         PA    Q R+P    PL L
Sbjct: 317 AQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTL 353


>gi|37675280 ajuba isoform 2 [Homo sapiens]
          Length = 121

 Score =  196 bits (499), Expect = 5e-50
 Identities = 77/114 (67%), Positives = 96/114 (84%)

Query: 552 LGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSD 611
           +GKSYHPGCFRC++CN+CLDG+PFTVD  N++YCV DYHK  APKCAACG PILP EG +
Sbjct: 1   MGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCE 60

Query: 612 ETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKR 665
           + +RV+SMDRDYH ECYHCEDC ++L+DE+G  C+PL+ HL CH CH++RL  R
Sbjct: 61  DIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNAR 114



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 12/86 (13%)

Query: 489 MGNLYHDTCFTCAACSRKLRGKAFYF-VNGKVFCEEDFLYSGFQQSADRCFLCGHLIM-- 545
           MG  YH  CF C  C++ L G  F    + +V+C  D+     +  A +C  CG  I+  
Sbjct: 1   MGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDY----HKNYAPKCAACGQPILPS 56

Query: 546 ----DMI-LQALGKSYHPGCFRCVIC 566
               D++ + ++ + YH  C+ C  C
Sbjct: 57  EGCEDIVRVISMDRDYHFECYHCEDC 82


>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
          Length = 373

 Score =  184 bits (468), Expect = 2e-46
 Identities = 111/330 (33%), Positives = 160/330 (48%), Gaps = 23/330 (6%)

Query: 333 PQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPV 392
           P PW   G  +    +AP       +G      P L  +    DL   P   P     PV
Sbjct: 60  PSPWTTPGRAAATVPAAPMQL---FNGGCPPPPPVLDGEDVLPDLDLLPPPPPPP---PV 113

Query: 393 MSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEAL 452
           +  LP       P+G S    L  + L SP  P  + P +    GP ++P       E L
Sbjct: 114 L--LPSEEEAPAPMGASLIADLEQLHL-SPPPPPPQAPAE----GPSVQPGPLRPMEEEL 166

Query: 453 TQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAF 512
                  ++     D    C  C K V     A +AM   YH  CFTC  C R+L G++F
Sbjct: 167 PPPPAEPVEKGASTDI---CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSF 223

Query: 513 YFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDG 572
           Y  +G+  CE  +     Q + +RC  CG ++ D I++ALG+++HP CF CV C  C+  
Sbjct: 224 YQKDGRPLCEPCY-----QDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGD 278

Query: 573 VPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCED 632
             F + S+N++YC+ D+++  AP C+ C  PI+P +G D   ++  M R++H  CY CED
Sbjct: 279 ESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKD-AFKIECMGRNFHENCYRCED 337

Query: 633 CGLELNDEDGHR-CYPLEDHLFCHSCHVKR 661
           C + L+ E   + CYPL +HLFC  CHVKR
Sbjct: 338 CRILLSVEPTDQGCYPLNNHLFCKPCHVKR 367


>gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]
          Length = 276

 Score =  176 bits (446), Expect = 6e-44
 Identities = 79/191 (41%), Positives = 115/191 (60%), Gaps = 7/191 (3%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C  C K V     A +AM   YH  CFTC  C R+L G++FY  +G+  CE  +     Q
Sbjct: 86  CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY-----Q 140

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
            + +RC  CG ++ D I++ALG+++HP CF CV C  C+    F + S+N++YC+ D+++
Sbjct: 141 DTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYR 200

Query: 592 VLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHR-CYPLED 650
             AP C+ C  PI+P +G D   ++  M R++H  CY CEDC + L+ E   + CYPL +
Sbjct: 201 KFAPVCSICENPIIPRDGKD-AFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNN 259

Query: 651 HLFCHSCHVKR 661
           HLFC  CHVKR
Sbjct: 260 HLFCKPCHVKR 270


>gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens]
          Length = 374

 Score =  117 bits (293), Expect = 3e-26
 Identities = 80/269 (29%), Positives = 118/269 (43%), Gaps = 21/269 (7%)

Query: 333 PQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPV 392
           P PW   G  +    +AP       +G      P L  +    DL   P   P     PV
Sbjct: 60  PSPWTTPGRAAATVPAAPMQL---FNGGCPPPPPVLDGEDVLPDLDLLPPPPPPP---PV 113

Query: 393 MSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEAL 452
           +  LP       P+G S    L  + L SP  P  + P +    GP ++P       E L
Sbjct: 114 L--LPSEEEAPAPMGASLIADLEQLHL-SPPPPPPQAPAE----GPSVQPGPLRPMEEEL 166

Query: 453 TQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAF 512
                  ++     D    C  C K V     A +AM   YH  CFTC  C R+L G++F
Sbjct: 167 PPPPAEPVEKGASTDI---CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSF 223

Query: 513 YFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDG 572
           Y  +G+  CE  +     Q + +RC  CG ++ D I++ALG+++HP CF CV C  C+  
Sbjct: 224 YQKDGRPLCEPCY-----QDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGD 278

Query: 573 VPFTVDSENKIYCVRDYHKVLAPKCAACG 601
             F + S+N++YC+ D+++     C   G
Sbjct: 279 ESFALGSQNEVYCLDDFYRYEKGLCTGWG 307



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 11/110 (10%)

Query: 533 SADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYH 590
           S D C  C   +   ++ ++A+ + YH  CF C  C   L G  F    + +  C   Y 
Sbjct: 179 STDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSF-YQKDGRPLCEPCYQ 237

Query: 591 KVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDE 640
             L  +C  CG  +      D  IR  ++ + +H  C+ C  C   + DE
Sbjct: 238 DTLE-RCGKCGEVV-----RDHIIR--ALGQAFHPSCFTCVTCARCIGDE 279



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 8/68 (11%)

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHS 656
           CA C   + P E     + V +M R YH +C+ C  C  +L    G   Y  +    C  
Sbjct: 183 CAFCHKTVSPRE-----LAVEAMKRQYHAQCFTCRTCRRQL---AGQSFYQKDGRPLCEP 234

Query: 657 CHVKRLEK 664
           C+   LE+
Sbjct: 235 CYQDTLER 242


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  107 bits (267), Expect = 4e-23
 Identities = 109/446 (24%), Positives = 175/446 (39%), Gaps = 68/446 (15%)

Query: 197 SPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSL-SSSRSSEGSLGGQNSGIGGRS 255
           SP  G S  +   S+P     +  PC          S  +  +S+E S    ++ +G   
Sbjct: 85  SPVYGSSAKTSSVSNPQDS--VGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNL 142

Query: 256 SEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSN 315
           SE    L    + Q   PG P+    +  P  G + P                 G+P +N
Sbjct: 143 SELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLY---------------GVPETN 187

Query: 316 SGLGGEVSGVMS-KPNVDPQPWFQDGPKSY------LSSSAPSSSPAGLDGSQQGAVPGL 368
           S LGG+   +   KP  +     +D   S       L SS PS  PA      + + P  
Sbjct: 188 SPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSP-- 245

Query: 369 GPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVR 428
                 T      ++S +S        L EL        + + G  GS      SSP   
Sbjct: 246 ---QRVTSTQQQTRISASSATRE----LDELMASLSDFKFMAQGKTGS------SSP--- 289

Query: 429 LPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYF-GACVKCSKGVFGAGQACQ 487
                  PG   +P +   +L+++   L+ +++    A    G C  C K +  AGQ   
Sbjct: 290 -------PGGPPKPGS---QLDSMLGSLQSDLNKLGVATVAKGVCGACKKPI--AGQVVT 337

Query: 488 AMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDM 547
           AMG  +H   F C  C  ++  + F+  +G+ +CE+D+        + RC+ C   I+D 
Sbjct: 338 AMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDY----HNLFSPRCYYCNGPILDK 393

Query: 548 ILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPP 607
           ++ AL +++HP  F C  C        F  + + K YC +DY  + APKC  C   IL  
Sbjct: 394 VVTALDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMFAPKCGGCARAILEN 452

Query: 608 EGSDETIRVVSMDRDYHVECYHCEDC 633
                   + +++  +H EC+ C +C
Sbjct: 453 -------YISALNTLWHPECFVCREC 471



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 8/107 (7%)

Query: 537 CFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPK 596
           C  C   I   ++ A+GK++HP  F C  C E +    F  + + + YC +DYH + +P+
Sbjct: 324 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNF-FERDGQPYCEKDYHNLFSPR 382

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGH 643
           C  C  PIL          V ++DR +H E + C  CG     E  H
Sbjct: 383 CYYCNGPILDKV-------VTALDRTWHPEHFFCAQCGAFFGPEGFH 422



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 11/140 (7%)

Query: 457 EREMDAHPKADYFGA----CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAF 512
           E++  A+ + DYF      C  C++ +        A+  L+H  CF C  C       +F
Sbjct: 423 EKDGKAYCRKDYFDMFAPKCGGCARAILE--NYISALNTLWHPECFVCRECFTPFVNGSF 480

Query: 513 YFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDG 572
           +  +G+ +CE  +     ++    C  C   I    + A+ K +HP  F C  C + L+ 
Sbjct: 481 FEHDGQPYCEVHY----HERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNK 536

Query: 573 VPFTVDSENKIYCVRDYHKV 592
             F  +  +K YC   + K+
Sbjct: 537 GTFK-EQNDKPYCQNCFLKL 555


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  104 bits (259), Expect = 3e-22
 Identities = 97/394 (24%), Positives = 157/394 (39%), Gaps = 65/394 (16%)

Query: 248 NSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPR 307
           ++ +G   SE    L    + Q   PG P+    +  P  G + P               
Sbjct: 2   STSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLY------------- 48

Query: 308 QGGLPRSNSGLGGEVSGVMS-KPNVDPQPWFQDGPKSY------LSSSAPSSSPAGLDGS 360
             G+P +NS LGG+   +   KP  +     +D   S       L SS PS  PA     
Sbjct: 49  --GVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQ 106

Query: 361 QQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLD 420
            + + P        T      ++S +S        L EL        + + G  GS    
Sbjct: 107 GEMSSP-----QRVTSTQQQTRISASSATRE----LDELMASLSDFKFMAQGKTGS---- 153

Query: 421 SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYF-GACVKCSKGV 479
             SSP          PG   +P +   +L+++   L+ +++    A    G C  C K +
Sbjct: 154 --SSP----------PGGPPKPGS---QLDSMLGSLQSDLNKLGVATVAKGVCGACKKPI 198

Query: 480 FGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFL 539
             AGQ   AMG  +H   F C  C  ++  + F+  +G+ +CE+D+        + RC+ 
Sbjct: 199 --AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDY----HNLFSPRCYY 252

Query: 540 CGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAA 599
           C   I+D ++ AL +++HP  F C  C        F  + + K YC +DY  + APKC  
Sbjct: 253 CNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMFAPKCGG 311

Query: 600 CGLPILPPEGSDETIRVVSMDRDYHVECYHCEDC 633
           C   IL          + +++  +H EC+ C +C
Sbjct: 312 CARAILEN-------YISALNTLWHPECFVCREC 338



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 8/107 (7%)

Query: 537 CFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPK 596
           C  C   I   ++ A+GK++HP  F C  C E +    F  + + + YC +DYH + +P+
Sbjct: 191 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNF-FERDGQPYCEKDYHNLFSPR 249

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGH 643
           C  C  PIL          V ++DR +H E + C  CG     E  H
Sbjct: 250 CYYCNGPILDKV-------VTALDRTWHPEHFFCAQCGAFFGPEGFH 289



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 11/140 (7%)

Query: 457 EREMDAHPKADYFGA----CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAF 512
           E++  A+ + DYF      C  C++ +        A+  L+H  CF C  C       +F
Sbjct: 290 EKDGKAYCRKDYFDMFAPKCGGCARAILE--NYISALNTLWHPECFVCRECFTPFVNGSF 347

Query: 513 YFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDG 572
           +  +G+ +CE  +     ++    C  C   I    + A+ K +HP  F C  C + L+ 
Sbjct: 348 FEHDGQPYCEVHY----HERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNK 403

Query: 573 VPFTVDSENKIYCVRDYHKV 592
             F  +  +K YC   + K+
Sbjct: 404 GTFK-EQNDKPYCQNCFLKL 422


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  100 bits (250), Expect = 3e-21
 Identities = 108/460 (23%), Positives = 175/460 (38%), Gaps = 62/460 (13%)

Query: 197 SPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSL-SSSRSSEGSLGGQNSGIGGRS 255
           SP  G S  +   S+P     +  PC          S  +  +S+E S    ++ +G   
Sbjct: 85  SPVYGSSAKTSSVSNPQDS--VGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNL 142

Query: 256 SEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSN 315
           SE    L    + Q   PG P+    +  P  G + P                 G+P +N
Sbjct: 143 SELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLY---------------GVPETN 187

Query: 316 SGLGGEVSGVMS-KPNVDPQPWFQDGPKSY------LSSSAPSSSPAGLDGSQQGAVPGL 368
           S LGG+   +   KP  +     +D   S       L SS PS  PA      + + P  
Sbjct: 188 SPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSP-- 245

Query: 369 GPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKE-------------GPLGWSSDGSLG 415
                 T      ++S +S    +   +  LS  +                GW  DG   
Sbjct: 246 ---QRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAGWPRDGGRS 302

Query: 416 SVL-LDSPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYF-GACV 473
           S    D               PG   +P +   +L+++   L+ +++    A    G C 
Sbjct: 303 SPGGQDEGGFMAQGKTGSSSPPGGPPKPGS---QLDSMLGSLQSDLNKLGVATVAKGVCG 359

Query: 474 KCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQS 533
            C K +  AGQ   AMG  +H   F C  C  ++  + F+  +G+ +CE+D+        
Sbjct: 360 ACKKPI--AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDY----HNLF 413

Query: 534 ADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVL 593
           + RC+ C   I+D ++ AL +++HP  F C  C        F  + + K YC +DY  + 
Sbjct: 414 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMF 472

Query: 594 APKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDC 633
           APKC  C   IL          + +++  +H EC+ C +C
Sbjct: 473 APKCGGCARAILEN-------YISALNTLWHPECFVCREC 505



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 8/107 (7%)

Query: 537 CFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPK 596
           C  C   I   ++ A+GK++HP  F C  C E +    F  + + + YC +DYH + +P+
Sbjct: 358 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNF-FERDGQPYCEKDYHNLFSPR 416

Query: 597 CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGH 643
           C  C  PIL          V ++DR +H E + C  CG     E  H
Sbjct: 417 CYYCNGPILDKV-------VTALDRTWHPEHFFCAQCGAFFGPEGFH 456



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 11/140 (7%)

Query: 457 EREMDAHPKADYFGA----CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAF 512
           E++  A+ + DYF      C  C++ +        A+  L+H  CF C  C       +F
Sbjct: 457 EKDGKAYCRKDYFDMFAPKCGGCARAILE--NYISALNTLWHPECFVCRECFTPFVNGSF 514

Query: 513 YFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDG 572
           +  +G+ +CE  +     ++    C  C   I    + A+ K +HP  F C  C + L+ 
Sbjct: 515 FEHDGQPYCEVHY----HERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNK 570

Query: 573 VPFTVDSENKIYCVRDYHKV 592
             F  +  +K YC   + K+
Sbjct: 571 GTFK-EQNDKPYCQNCFLKL 589


>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
           sapiens]
          Length = 325

 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 60/197 (30%), Positives = 87/197 (44%), Gaps = 27/197 (13%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C  G   A +   + G LYH+ CF CA C ++     FY   G+ +CE DF      
Sbjct: 10  CERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQ----M 65

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYC------ 585
             A  C  CG  I+  +++A+  S+HP CFRC +C E L  + F V +  +  C      
Sbjct: 66  LFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGF-VKNAGRHLCRPCHNR 124

Query: 586 --VRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGH 643
              R   K +  KC A           DE   +   D  YH + ++C +CG EL  +   
Sbjct: 125 EKARGLGKYICQKCHAI---------IDEQPLIFKND-PYHPDHFNCANCGKELTAD--- 171

Query: 644 RCYPLEDHLFCHSCHVK 660
               L+  L+C  CH K
Sbjct: 172 -ARELKGELYCLPCHDK 187



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 43/146 (29%), Positives = 62/146 (42%), Gaps = 8/146 (5%)

Query: 448 KLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
           +L A  + L+ E+   P  D  G   C  C + +   G+   AMG  +H   F CA C +
Sbjct: 167 ELTADARELKGELYCLPCHDKMGVPICGACRRPI--EGRVVNAMGKQWHVEHFVCAKCEK 224

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
              G   Y   G  +CE  +     Q   D CF C  +I   ++ AL K++   CF C  
Sbjct: 225 PFLGHRHYERKGLAYCETHYN----QLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACST 280

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHK 591
           CN  L      V+ + K  C + Y K
Sbjct: 281 CNTKLTLKNKFVEFDMKPVCKKCYEK 306


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 103/449 (22%), Positives = 161/449 (35%), Gaps = 51/449 (11%)

Query: 226 PLNHRQLSLSSSRSSEGSLGGQNSGIGGRSSEKP---TGLWSTASSQRVSPGLPSPNLEN 282
           P+ H  +  S + +       Q       S+  P   T    TA +   +    S   ++
Sbjct: 301 PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS 360

Query: 283 GAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNV---------DP 333
             P      P   + SAP   +   +G  P + +     V+    +P+V          P
Sbjct: 361 PRPQASSYSPAVAASSAPATHTSYSEG--PAAPAPKPRVVTTASIRPSVYQPVPASTYSP 418

Query: 334 QPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVM 393
            P     P  Y  S AP+ +P+         VP   P P        P  +P+    P  
Sbjct: 419 SPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPA-------PAYTPSPA--PNY 469

Query: 394 STLPELSCKEGPLG------WSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAEL 447
           +  P ++   GP        W +D S         S+  +     P   GP   P+  ++
Sbjct: 470 NPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPR-GGPAYTPAGPQV 528

Query: 448 K--LEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
                   QR ER   A  +    G C    +G F       AMG  +H   FTCA C  
Sbjct: 529 PPLARGTVQRAER-FPASSRTPLCGHCNNVIRGPF-----LVAMGRSWHPEEFTCAYCKT 582

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
            L    F      V+CE  +     Q  A  C  C   IM  ++ AL +++H  CF C  
Sbjct: 583 SLADVCFVEEQNNVYCERCY----EQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAA 638

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHV 625
           C +      F ++ + + YC +DY  + + KC  C  P+   E  D+ I   ++   +H 
Sbjct: 639 CKKPFGNSLFHME-DGEPYCEKDYINLFSTKCHGCDFPV---EAGDKFIE--ALGHTWHD 692

Query: 626 ECYHCEDCGLELNDEDGHRCYPLEDHLFC 654
            C+ C  C + L   +G   Y  +D   C
Sbjct: 693 TCFICAVCHVNL---EGQPFYSKKDRPLC 718



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 96/432 (22%), Positives = 159/432 (36%), Gaps = 58/432 (13%)

Query: 186 ASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPP-LPKPCGDHPLNHRQLSLSSSRSSEGSL 244
           ASP     P  + +   ++ S   ++P S P   P+P        +  S S + ++  + 
Sbjct: 327 ASPSAASPPLATAAAHTAIASASTTAPASSPADSPRP--------QASSYSPAVAASSAP 378

Query: 245 GGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALS 304
               S   G ++  P     T +S R S   P P     +P+ G     TP   +P    
Sbjct: 379 ATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVP-ASTYSPSPGANYSPTPYTPSPAPAY 437

Query: 305 CPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPK-SYLSSSAPSSSPAGLDGSQQG 363
            P        +                 P P +   P  +Y  S AP+ +PA       G
Sbjct: 438 TPSPAPAYTPS-----------------PVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG 480

Query: 364 AVPGLGPKPGCTDLGTGPKLSPTSLVHPVMS-TLPELSCKEGPLGWSSDGSLGSVLLDS- 421
                   P  TD     K +P      +   TLP       P G          +  + 
Sbjct: 481 PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE 540

Query: 422 --PSSPRVRL--PCQPLVPGPELRPSAAELKLEALTQR-----------LEREMDAHPKA 466
             P+S R  L   C  ++ GP L         E  T             +E + + + + 
Sbjct: 541 RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER 600

Query: 467 DY--FGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCE 522
            Y  F A  C KC+  + G  +   A+   +H TCF CAAC +      F+  +G+ +CE
Sbjct: 601 CYEQFFAPLCAKCNTKIMG--EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 658

Query: 523 EDFLYSGFQQSADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSE 580
           +D++       + +C  C   +   D  ++ALG ++H  CF C +C+  L+G PF    +
Sbjct: 659 KDYI----NLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPF-YSKK 713

Query: 581 NKIYCVRDYHKV 592
           ++  C +  H +
Sbjct: 714 DRPLCKKHAHTI 725



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 43/135 (31%), Positives = 62/135 (45%), Gaps = 17/135 (12%)

Query: 533 SADRCFLCGH---LIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           ++ R  LCGH   +I    L A+G+S+HP  F C  C   L  V F V+ +N +YC R Y
Sbjct: 544 ASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCF-VEEQNNVYCERCY 602

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELND-----EDGH- 643
            +  AP CA C   I+      E +   ++ + +H  C+ C  C     +     EDG  
Sbjct: 603 EQFFAPLCAKCNTKIM-----GEVMH--ALRQTWHTTCFVCAACKKPFGNSLFHMEDGEP 655

Query: 644 RCYPLEDHLFCHSCH 658
            C     +LF   CH
Sbjct: 656 YCEKDYINLFSTKCH 670


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 56/164 (34%), Positives = 81/164 (49%), Gaps = 14/164 (8%)

Query: 470 GACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSG 529
           G C  C+K +  AGQ   A+G  +H   F C  CS  L G +F+  +G  FC E +    
Sbjct: 226 GLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECY---- 279

Query: 530 FQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           F++ + RC  C   I   ++ ALG  +HP  F CV C E      F  + E + YC RD+
Sbjct: 280 FERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFH-EREGRPYCRRDF 338

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDC 633
            ++ AP+C  C  PIL     D  I  +S    +H +C+ C +C
Sbjct: 339 LQLFAPRCQGCQGPIL-----DNYISALS--ALWHPDCFVCREC 375



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 46/147 (31%), Positives = 64/147 (43%), Gaps = 14/147 (9%)

Query: 488 AMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDM 547
           A+G  +H   F C +C      + F+   G+ +C  DFL    Q  A RC  C   I+D 
Sbjct: 301 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFL----QLFAPRCQGCQGPILDN 356

Query: 548 ILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPP 607
            + AL   +HP CF C  C     G  F  + E +  C   +H      CA CGLP+   
Sbjct: 357 YISALSALWHPDCFVCRECFAPFSGGSF-FEHEGRPLCENHFHARRGSLCATCGLPV--- 412

Query: 608 EGSDETIRVVS-MDRDYHVECYHCEDC 633
                T R VS + R +H + + C  C
Sbjct: 413 -----TGRCVSALGRRFHPDHFTCTFC 434



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 82/364 (22%), Positives = 125/364 (34%), Gaps = 60/364 (16%)

Query: 282 NGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGP 341
           +GAP   P +P TP          P  G  P++ SG     SG   K ++         P
Sbjct: 21  SGAPKERPAEPLTPP---------PSYGHQPQTGSGESSGASG--DKDHLYSTVCKPRSP 69

Query: 342 KSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSC 401
           K    ++ P SS +G+ G+    +  L  +   T           ++   +MS  P    
Sbjct: 70  KPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQF---------NITDEIMSQFP---- 116

Query: 402 KEGPLGWSSDGSLGSVLLD-SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRL-ERE 459
                  SS  + G    D S    R  LP  P    P+   ++A L+L+ L   L +  
Sbjct: 117 -------SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFR 169

Query: 460 MDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKV 519
           +  H  A         S    G+    +  G    DT           RG          
Sbjct: 170 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVP-------- 221

Query: 520 FCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDS 579
                       Q+   C  C   I   ++ ALG+++HP  F C  C+  L G  F  + 
Sbjct: 222 -----------TQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSF-FEK 269

Query: 580 ENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELND 639
           +   +C   Y +  +P+C  C  PI           V ++   +H E + C  CG    D
Sbjct: 270 DGAPFCPECYFERFSPRCGFCNQPI-------RHKMVTALGTHWHPEHFCCVSCGEPFGD 322

Query: 640 EDGH 643
           E  H
Sbjct: 323 EGFH 326



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 29/98 (29%), Positives = 40/98 (40%), Gaps = 5/98 (5%)

Query: 488 AMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDM 547
           A+  L+H  CF C  C     G +F+   G+  CE  F      +    C  CG  +   
Sbjct: 360 ALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHF----HARRGSLCATCGLPVTGR 415

Query: 548 ILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYC 585
            + ALG+ +HP  F C  C   L    F  +   K YC
Sbjct: 416 CVSALGRRFHPDHFTCTFCLRPLTKGSFQ-ERAGKPYC 452



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 2/55 (3%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFL 526
           C  C   V   G+   A+G  +H   FTC  C R L   +F    GK +C+  FL
Sbjct: 405 CATCGLPV--TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFL 457


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 56/164 (34%), Positives = 81/164 (49%), Gaps = 14/164 (8%)

Query: 470 GACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSG 529
           G C  C+K +  AGQ   A+G  +H   F C  CS  L G +F+  +G  FC E +    
Sbjct: 209 GLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECY---- 262

Query: 530 FQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           F++ + RC  C   I   ++ ALG  +HP  F CV C E      F  + E + YC RD+
Sbjct: 263 FERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFH-EREGRPYCRRDF 321

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDC 633
            ++ AP+C  C  PIL     D  I  +S    +H +C+ C +C
Sbjct: 322 LQLFAPRCQGCQGPIL-----DNYISALS--ALWHPDCFVCREC 358



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 46/147 (31%), Positives = 64/147 (43%), Gaps = 14/147 (9%)

Query: 488 AMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDM 547
           A+G  +H   F C +C      + F+   G+ +C  DFL    Q  A RC  C   I+D 
Sbjct: 284 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFL----QLFAPRCQGCQGPILDN 339

Query: 548 ILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPP 607
            + AL   +HP CF C  C     G  F  + E +  C   +H      CA CGLP+   
Sbjct: 340 YISALSALWHPDCFVCRECFAPFSGGSF-FEHEGRPLCENHFHARRGSLCATCGLPV--- 395

Query: 608 EGSDETIRVVS-MDRDYHVECYHCEDC 633
                T R VS + R +H + + C  C
Sbjct: 396 -----TGRCVSALGRRFHPDHFTCTFC 417



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 82/364 (22%), Positives = 125/364 (34%), Gaps = 60/364 (16%)

Query: 282 NGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGP 341
           +GAP   P +P TP          P  G  P++ SG     SG   K ++         P
Sbjct: 4   SGAPKERPAEPLTPP---------PSYGHQPQTGSGESSGASG--DKDHLYSTVCKPRSP 52

Query: 342 KSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSC 401
           K    ++ P SS +G+ G+    +  L  +   T           ++   +MS  P    
Sbjct: 53  KPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQF---------NITDEIMSQFP---- 99

Query: 402 KEGPLGWSSDGSLGSVLLD-SPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRL-ERE 459
                  SS  + G    D S    R  LP  P    P+   ++A L+L+ L   L +  
Sbjct: 100 -------SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFR 152

Query: 460 MDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKV 519
           +  H  A         S    G+    +  G    DT           RG          
Sbjct: 153 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVP-------- 204

Query: 520 FCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDS 579
                       Q+   C  C   I   ++ ALG+++HP  F C  C+  L G  F  + 
Sbjct: 205 -----------TQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSF-FEK 252

Query: 580 ENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELND 639
           +   +C   Y +  +P+C  C  PI           V ++   +H E + C  CG    D
Sbjct: 253 DGAPFCPECYFERFSPRCGFCNQPI-------RHKMVTALGTHWHPEHFCCVSCGEPFGD 305

Query: 640 EDGH 643
           E  H
Sbjct: 306 EGFH 309



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 29/98 (29%), Positives = 40/98 (40%), Gaps = 5/98 (5%)

Query: 488 AMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDM 547
           A+  L+H  CF C  C     G +F+   G+  CE  F      +    C  CG  +   
Sbjct: 343 ALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHF----HARRGSLCATCGLPVTGR 398

Query: 548 ILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYC 585
            + ALG+ +HP  F C  C   L    F  +   K YC
Sbjct: 399 CVSALGRRFHPDHFTCTFCLRPLTKGSFQ-ERAGKPYC 435



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 2/55 (3%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFL 526
           C  C   V   G+   A+G  +H   FTC  C R L   +F    GK +C+  FL
Sbjct: 388 CATCGLPV--TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFL 440


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 57/197 (28%), Positives = 86/197 (43%), Gaps = 23/197 (11%)

Query: 470 GACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSG 529
           G C  C K +  AG+   A+G  +H   F C  C  ++    F+  +G  +C  D+    
Sbjct: 155 GHCASCQKPI--AGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDY---- 208

Query: 530 FQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
            Q  + RC  C   I+D +L A+ +++HP  F C  C E      F  + + K YC +D+
Sbjct: 209 HQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFH-EKDKKPYCRKDF 267

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELN-----DEDGHR 644
             + +PKC  C  P+L    S       +MD  +H EC+ C DC    +     + DG  
Sbjct: 268 LAMFSPKCGGCNRPVLENYLS-------AMDTVWHPECFVCGDCFTSFSTGSFFELDGRP 320

Query: 645 CYPLEDH----LFCHSC 657
              L  H      CH C
Sbjct: 321 FCELHYHHRRGTLCHGC 337



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 22/189 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C  C+  +    +   AM   +H   F C+ C      + F+  + K +C +DFL     
Sbjct: 216 CAYCAAPILD--KVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFL----A 269

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             + +C  C   +++  L A+   +HP CF C  C        F  + + + +C   YH 
Sbjct: 270 MFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSF-FELDGRPFCELHYHH 328

Query: 592 VLAPKCAACGLPILPPEGSDETIRVVS-MDRDYHVECYHCEDC------GLELNDEDGHR 644
                C  CG PI        T R +S M   +H E + C  C      G+     D   
Sbjct: 329 RRGTLCHGCGQPI--------TGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTY 380

Query: 645 CYPLEDHLF 653
           C P  + LF
Sbjct: 381 CQPCFNKLF 389


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 57/197 (28%), Positives = 86/197 (43%), Gaps = 23/197 (11%)

Query: 470 GACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSG 529
           G C  C K +  AG+   A+G  +H   F C  C  ++    F+  +G  +C  D+    
Sbjct: 150 GHCASCQKPI--AGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDY---- 203

Query: 530 FQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
            Q  + RC  C   I+D +L A+ +++HP  F C  C E      F  + + K YC +D+
Sbjct: 204 HQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFH-EKDKKPYCRKDF 262

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELN-----DEDGHR 644
             + +PKC  C  P+L    S       +MD  +H EC+ C DC    +     + DG  
Sbjct: 263 LAMFSPKCGGCNRPVLENYLS-------AMDTVWHPECFVCGDCFTSFSTGSFFELDGRP 315

Query: 645 CYPLEDH----LFCHSC 657
              L  H      CH C
Sbjct: 316 FCELHYHHRRGTLCHGC 332



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 22/189 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C  C+  +    +   AM   +H   F C+ C      + F+  + K +C +DFL     
Sbjct: 211 CAYCAAPILD--KVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFL----A 264

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             + +C  C   +++  L A+   +HP CF C  C        F  + + + +C   YH 
Sbjct: 265 MFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSF-FELDGRPFCELHYHH 323

Query: 592 VLAPKCAACGLPILPPEGSDETIRVVS-MDRDYHVECYHCEDC------GLELNDEDGHR 644
                C  CG PI        T R +S M   +H E + C  C      G+     D   
Sbjct: 324 RRGTLCHGCGQPI--------TGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTY 375

Query: 645 CYPLEDHLF 653
           C P  + LF
Sbjct: 376 CQPCFNKLF 384


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 94/392 (23%), Positives = 143/392 (36%), Gaps = 48/392 (12%)

Query: 280 LENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNV-------- 331
           L    P      P   + SAP   +   +G  P + +     V+    +P+V        
Sbjct: 248 LRRSRPQASSYSPAVAASSAPATHTSYSEG--PAAPAPKPRVVTTASIRPSVYQPVPAST 305

Query: 332 -DPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVH 390
             P P     P  Y  S AP+ +P+         VP   P P        P  +P+    
Sbjct: 306 YSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPA-------PAYTPSPA-- 356

Query: 391 PVMSTLPELSCKEGPLG------WSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSA 444
           P  +  P ++   GP        W +D S         S+  +     P   GP   P+ 
Sbjct: 357 PNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPR-GGPAYTPAG 415

Query: 445 AELK--LEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAA 502
            ++        QR ER   A  +    G C    +G F       AMG  +H   FTCA 
Sbjct: 416 PQVPPLARGTVQRAER-FPASSRTPLCGHCNNVIRGPF-----LVAMGRSWHPEEFTCAY 469

Query: 503 CSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFR 562
           C   L    F      V+CE  +     Q  A  C  C   IM  ++ AL +++H  CF 
Sbjct: 470 CKTSLADVCFVEEQNNVYCERCY----EQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFV 525

Query: 563 CVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRD 622
           C  C +      F ++ + + YC +DY  + + KC  C  P+   E  D+ I   ++   
Sbjct: 526 CAACKKPFGNSLFHME-DGEPYCEKDYINLFSTKCHGCDFPV---EAGDKFIE--ALGHT 579

Query: 623 YHVECYHCEDCGLELNDEDGHRCYPLEDHLFC 654
           +H  C+ C  C + L   +G   Y  +D   C
Sbjct: 580 WHDTCFICAVCHVNL---EGQPFYSKKDRPLC 608



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 85/359 (23%), Positives = 134/359 (37%), Gaps = 42/359 (11%)

Query: 264 STASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSC--PRQGG----LPRSNSG 317
           +T +S    P  P+P      P V       PSV  P+  S   P  G      P + S 
Sbjct: 269 ATHTSYSEGPAAPAPK-----PRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSP 323

Query: 318 LGGEVSGVMSKPNVDPQPWFQDGPK-SYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTD 376
                          P P +   P  +Y  S AP+ +PA       G        P  TD
Sbjct: 324 APAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTD 383

Query: 377 LGTGPKLSPTSLVHPVMS-TLPELSCKEGPLGWSSDGSLGSVLLDS---PSSPRVRL--P 430
                K +P      +   TLP       P G          +  +   P+S R  L   
Sbjct: 384 DSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGH 443

Query: 431 CQPLVPGPELRPSAAELKLEALTQR-----------LEREMDAHPKADY--FGA--CVKC 475
           C  ++ GP L         E  T             +E + + + +  Y  F A  C KC
Sbjct: 444 CNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKC 503

Query: 476 SKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSAD 535
           +  + G  +   A+   +H TCF CAAC +      F+  +G+ +CE+D++       + 
Sbjct: 504 NTKIMG--EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYI----NLFST 557

Query: 536 RCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKV 592
           +C  C   +   D  ++ALG ++H  CF C +C+  L+G PF    +++  C +  H +
Sbjct: 558 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPF-YSKKDRPLCKKHAHTI 615



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 43/135 (31%), Positives = 62/135 (45%), Gaps = 17/135 (12%)

Query: 533 SADRCFLCGH---LIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           ++ R  LCGH   +I    L A+G+S+HP  F C  C   L  V F V+ +N +YC R Y
Sbjct: 434 ASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCF-VEEQNNVYCERCY 492

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELND-----EDGH- 643
            +  AP CA C   I+      E +   ++ + +H  C+ C  C     +     EDG  
Sbjct: 493 EQFFAPLCAKCNTKIM-----GEVMH--ALRQTWHTTCFVCAACKKPFGNSLFHMEDGEP 545

Query: 644 RCYPLEDHLFCHSCH 658
            C     +LF   CH
Sbjct: 546 YCEKDYINLFSTKCH 560


>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
           1 [Homo sapiens]
          Length = 363

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 62/195 (31%), Positives = 86/195 (44%), Gaps = 23/195 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C      A +   + G LYH+ CF CA C R      FY   G+ +CE DF      
Sbjct: 37  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ----M 92

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             A  C  CG  I+  +++A+  ++HPGCFRC +C+  L  + F V +  +  C R  H 
Sbjct: 93  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLC-RPCHN 150

Query: 592 VLAPK------CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRC 645
               K      C  C L I      DE   +   D  YH + ++C  CG EL  E     
Sbjct: 151 REKAKGLGKYICQRCHLVI------DEQPLMFRSDA-YHPDHFNCTHCGKELTAE----A 199

Query: 646 YPLEDHLFCHSCHVK 660
             L+  L+C  CH K
Sbjct: 200 RELKGELYCLPCHDK 214



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 8/146 (5%)

Query: 448 KLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
           +L A  + L+ E+   P  D  G   C  C + +   G+   A+G  +H   F CA C +
Sbjct: 194 ELTAEARELKGELYCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWHVEHFVCAKCEK 251

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
              G   Y   G  +CE  +     Q   D C+ C H+I   ++ AL K++   CF C  
Sbjct: 252 PFLGHRHYEKKGLAYCETHYN----QLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCST 307

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHK 591
           CN  L      V+ + K  C R Y K
Sbjct: 308 CNSKLTLKNKFVEFDMKPVCKRCYEK 333


>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
           5 [Homo sapiens]
          Length = 336

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 62/195 (31%), Positives = 86/195 (44%), Gaps = 23/195 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C      A +   + G LYH+ CF CA C R      FY   G+ +CE DF      
Sbjct: 10  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ----M 65

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             A  C  CG  I+  +++A+  ++HPGCFRC +C+  L  + F V +  +  C R  H 
Sbjct: 66  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLC-RPCHN 123

Query: 592 VLAPK------CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRC 645
               K      C  C L I      DE   +   D  YH + ++C  CG EL  E     
Sbjct: 124 REKAKGLGKYICQRCHLVI------DEQPLMFRSDA-YHPDHFNCTHCGKELTAE----A 172

Query: 646 YPLEDHLFCHSCHVK 660
             L+  L+C  CH K
Sbjct: 173 RELKGELYCLPCHDK 187



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 8/146 (5%)

Query: 448 KLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
           +L A  + L+ E+   P  D  G   C  C + +   G+   A+G  +H   F CA C +
Sbjct: 167 ELTAEARELKGELYCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWHVEHFVCAKCEK 224

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
              G   Y   G  +CE  +     Q   D C+ C H+I   ++ AL K++   CF C  
Sbjct: 225 PFLGHRHYEKKGLAYCETHYN----QLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCST 280

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHK 591
           CN  L      V+ + K  C R Y K
Sbjct: 281 CNSKLTLKNKFVEFDMKPVCKRCYEK 306


>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
           3 [Homo sapiens]
          Length = 341

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 62/195 (31%), Positives = 86/195 (44%), Gaps = 23/195 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C      A +   + G LYH+ CF CA C R      FY   G+ +CE DF      
Sbjct: 15  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ----M 70

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             A  C  CG  I+  +++A+  ++HPGCFRC +C+  L  + F V +  +  C R  H 
Sbjct: 71  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLC-RPCHN 128

Query: 592 VLAPK------CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRC 645
               K      C  C L I      DE   +   D  YH + ++C  CG EL  E     
Sbjct: 129 REKAKGLGKYICQRCHLVI------DEQPLMFRSDA-YHPDHFNCTHCGKELTAE----A 177

Query: 646 YPLEDHLFCHSCHVK 660
             L+  L+C  CH K
Sbjct: 178 RELKGELYCLPCHDK 192



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 8/146 (5%)

Query: 448 KLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
           +L A  + L+ E+   P  D  G   C  C + +   G+   A+G  +H   F CA C +
Sbjct: 172 ELTAEARELKGELYCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWHVEHFVCAKCEK 229

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
              G   Y   G  +CE  +     Q   D C+ C H+I   ++ AL K++   CF C  
Sbjct: 230 PFLGHRHYEKKGLAYCETHYN----QLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCST 285

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHK 591
           CN  L      V+ + K  C R Y K
Sbjct: 286 CNSKLTLKNKFVEFDMKPVCKRCYEK 311


>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
           [Homo sapiens]
          Length = 365

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 62/195 (31%), Positives = 86/195 (44%), Gaps = 23/195 (11%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C      A +   + G LYH+ CF CA C R      FY   G+ +CE DF      
Sbjct: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ----M 94

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHK 591
             A  C  CG  I+  +++A+  ++HPGCFRC +C+  L  + F V +  +  C R  H 
Sbjct: 95  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGF-VKNAGRHLC-RPCHN 152

Query: 592 VLAPK------CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRC 645
               K      C  C L I      DE   +   D  YH + ++C  CG EL  E     
Sbjct: 153 REKAKGLGKYICQRCHLVI------DEQPLMFRSDA-YHPDHFNCTHCGKELTAE----A 201

Query: 646 YPLEDHLFCHSCHVK 660
             L+  L+C  CH K
Sbjct: 202 RELKGELYCLPCHDK 216



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 8/146 (5%)

Query: 448 KLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSR 505
           +L A  + L+ E+   P  D  G   C  C + +   G+   A+G  +H   F CA C +
Sbjct: 196 ELTAEARELKGELYCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWHVEHFVCAKCEK 253

Query: 506 KLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVI 565
              G   Y   G  +CE  +     Q   D C+ C H+I   ++ AL K++   CF C  
Sbjct: 254 PFLGHRHYEKKGLAYCETHYN----QLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCST 309

Query: 566 CNECLDGVPFTVDSENKIYCVRDYHK 591
           CN  L      V+ + K  C R Y K
Sbjct: 310 CNSKLTLKNKFVEFDMKPVCKRCYEK 335


>gi|239741720 PREDICTED: hypothetical protein XP_002342298 [Homo
           sapiens]
          Length = 248

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 54/176 (30%), Positives = 78/176 (44%), Gaps = 23/176 (13%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           C +C  G   A     + G LYH+ CF CA C ++     FY   G+ +CE DF      
Sbjct: 72  CERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQ----M 127

Query: 532 QSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYC------ 585
             A  C  CG  I+  +++A+  S+HP CFRC +C E L  + F V +  +  C      
Sbjct: 128 LFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGF-VKNAGRHLCRPCHNR 186

Query: 586 --VRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELND 639
              R   K +  KC A           DE   +   D  YH + ++C +CG E +D
Sbjct: 187 EKARGLGKYICQKCHAI---------IDEQPLIFKND-PYHPDHFNCANCGQEGSD 232


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 20/194 (10%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVF----CEEDFLY 527
           C  C K +    Q  +  G ++H  CFTC+ C + + G   +F  G+ F    C E    
Sbjct: 101 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVI-GTGSFFPKGEDFYCVTCHET--- 156

Query: 528 SGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVR 587
               + A  C  C   I    +    + +H  CF CV C++ L G  FT   E++ YCV 
Sbjct: 157 ----KFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTA-VEDQYYCVD 211

Query: 588 DYHKVLAPKCAACGLPILPPEGSDETIRVVSMD-RDYHVECYHCEDCGLELNDEDGHRCY 646
            Y   +A KCA C  PI    G  +   VV+ + + +H  C+HC+ C + L ++   R  
Sbjct: 212 CYKNFVAKKCAGCKNPI---TGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANK---RFV 265

Query: 647 PLEDHLFCHSCHVK 660
             ++ ++C  C  K
Sbjct: 266 FHQEQVYCPDCAKK 279



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 17/196 (8%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           CV+C K +    +        +HDTCF CA C   L  + F   + K+ C +       +
Sbjct: 40  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNK----CTTR 95

Query: 532 QSADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           + + +C  C   I+  D  ++  G  +H  CF C  C + +    F    E+  YCV  +
Sbjct: 96  EDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGED-FYCVTCH 154

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLE 649
               A  C  C   I        +  +   D+ +H +C+ C  C  +L    G R   +E
Sbjct: 155 ETKFAKHCVKCNKAI-------TSGGITYQDQPWHADCFVCVTCSKKL---AGQRFTAVE 204

Query: 650 DHLFCHSCHVKRLEKR 665
           D  +C  C+   + K+
Sbjct: 205 DQYYCVDCYKNFVAKK 220


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 20/194 (10%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVF----CEEDFLY 527
           C  C K +    Q  +  G ++H  CFTC+ C + + G   +F  G+ F    C E    
Sbjct: 101 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVI-GTGSFFPKGEDFYCVTCHET--- 156

Query: 528 SGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVR 587
               + A  C  C   I    +    + +H  CF CV C++ L G  FT   E++ YCV 
Sbjct: 157 ----KFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTA-VEDQYYCVD 211

Query: 588 DYHKVLAPKCAACGLPILPPEGSDETIRVVSMD-RDYHVECYHCEDCGLELNDEDGHRCY 646
            Y   +A KCA C  PI    G  +   VV+ + + +H  C+HC+ C + L ++   R  
Sbjct: 212 CYKNFVAKKCAGCKNPI---TGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANK---RFV 265

Query: 647 PLEDHLFCHSCHVK 660
             ++ ++C  C  K
Sbjct: 266 FHQEQVYCPDCAKK 279



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 17/196 (8%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           CV+C K +    +        +HDTCF CA C   L  + F   + K+ C +       +
Sbjct: 40  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNK----CTTR 95

Query: 532 QSADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           + + +C  C   I+  D  ++  G  +H  CF C  C + +    F    E+  YCV  +
Sbjct: 96  EDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGED-FYCVTCH 154

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLE 649
               A  C  C   I        +  +   D+ +H +C+ C  C  +L    G R   +E
Sbjct: 155 ETKFAKHCVKCNKAI-------TSGGITYQDQPWHADCFVCVTCSKKL---AGQRFTAVE 204

Query: 650 DHLFCHSCHVKRLEKR 665
           D  +C  C+   + K+
Sbjct: 205 DQYYCVDCYKNFVAKK 220


>gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]
          Length = 309

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 20/194 (10%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVF----CEEDFLY 527
           C  C K +    Q  +  G ++H  CFTC+ C + + G   +F  G+ F    C E    
Sbjct: 130 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVI-GTGSFFPKGEDFYCVTCHET--- 185

Query: 528 SGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVR 587
               + A  C  C   I    +    + +H  CF CV C++ L G  FT   E++ YCV 
Sbjct: 186 ----KFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTA-VEDQYYCVD 240

Query: 588 DYHKVLAPKCAACGLPILPPEGSDETIRVVSMD-RDYHVECYHCEDCGLELNDEDGHRCY 646
            Y   +A KCA C  PI    G  +   VV+ + + +H  C+HC+ C + L ++   R  
Sbjct: 241 CYKNFVAKKCAGCKNPI---TGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANK---RFV 294

Query: 647 PLEDHLFCHSCHVK 660
             ++ ++C  C  K
Sbjct: 295 FHQEQVYCPDCAKK 308



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 17/196 (8%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           CV+C K +    +        +HDTCF CA C   L  + F   + K+ C +       +
Sbjct: 69  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNK----CTTR 124

Query: 532 QSADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           + + +C  C   I+  D  ++  G  +H  CF C  C + +    F    E+  YCV  +
Sbjct: 125 EDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGED-FYCVTCH 183

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLE 649
               A  C  C   I        +  +   D+ +H +C+ C  C  +L    G R   +E
Sbjct: 184 ETKFAKHCVKCNKAI-------TSGGITYQDQPWHADCFVCVTCSKKL---AGQRFTAVE 233

Query: 650 DHLFCHSCHVKRLEKR 665
           D  +C  C+   + K+
Sbjct: 234 DQYYCVDCYKNFVAKK 249


>gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]
          Length = 296

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 20/194 (10%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVF----CEEDFLY 527
           C  C K +    Q  +  G ++H  CFTC+ C + + G   +F  G+ F    C E    
Sbjct: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVI-GTGSFFPKGEDFYCVTCHET--- 172

Query: 528 SGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVR 587
               + A  C  C   I    +    + +H  CF CV C++ L G  FT   E++ YCV 
Sbjct: 173 ----KFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTA-VEDQYYCVD 227

Query: 588 DYHKVLAPKCAACGLPILPPEGSDETIRVVSMD-RDYHVECYHCEDCGLELNDEDGHRCY 646
            Y   +A KCA C  PI    G  +   VV+ + + +H  C+HC+ C + L ++   R  
Sbjct: 228 CYKNFVAKKCAGCKNPI---TGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANK---RFV 281

Query: 647 PLEDHLFCHSCHVK 660
             ++ ++C  C  K
Sbjct: 282 FHQEQVYCPDCAKK 295



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 17/196 (8%)

Query: 472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQ 531
           CV+C K +    +        +HDTCF CA C   L  + F   + K+ C +       +
Sbjct: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNK----CTTR 111

Query: 532 QSADRCFLCGHLIM--DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY 589
           + + +C  C   I+  D  ++  G  +H  CF C  C + +    F    E+  YCV  +
Sbjct: 112 EDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGED-FYCVTCH 170

Query: 590 HKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLE 649
               A  C  C   I        +  +   D+ +H +C+ C  C  +L    G R   +E
Sbjct: 171 ETKFAKHCVKCNKAI-------TSGGITYQDQPWHADCFVCVTCSKKL---AGQRFTAVE 220

Query: 650 DHLFCHSCHVKRLEKR 665
           D  +C  C+   + K+
Sbjct: 221 DQYYCVDCYKNFVAKK 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,354,192
Number of Sequences: 37866
Number of extensions: 2123265
Number of successful extensions: 12246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 633
Number of HSP's that attempted gapping in prelim test: 9653
Number of HSP's gapped (non-prelim): 2457
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.