Guide to the Human Genome
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Name: PCSK4 Sequence: fasta or formatted (755aa) NCBI GI: 76443679
Description:

proprotein convertase subtilisin/kexin type 4

Referenced in:

Peptide-processing Enzymes

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.5         64           3
 C cysteine            3.0         23           1
 D aspartate           4.8         36           2
 E glutamate           2.6         20           1
 F phenylalanine       2.3         17           2
 G glycine             8.7         66           2
 H histidine           3.4         26           2
 I isoleucine          3.0         23           1
 K lysine              1.7         13           2
 L leucine             9.7         73           3
 M methionine          1.7         13           1
 N asparagine          3.2         24           2
 P proline             7.2         54           2
 Q glutamine           5.3         40           3
 R arginine            7.0         53           2
 S serine              7.3         55           2
 T threonine           7.7         58           3
 V valine              6.8         51           3
 W tryptophan          2.6         20           1
 Y tyrosine            3.4         26           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   proprotein convertase subtilisin/kexin type 4 
FURIN                 0.486   furin preproprotein 
PCSK6                 0.378   paired basic amino acid cleaving system 4 isoform h ...
PCSK6                 0.378   paired basic amino acid cleaving system 4 isoform b ...
PCSK5                 0.374   proprotein convertase subtilisin/kexin type 5 prepro...
PCSK6                 0.373   paired basic amino acid cleaving system 4 isoform g ...
PCSK6                 0.373   paired basic amino acid cleaving system 4 isoform a p...
PCSK6                 0.360   paired basic amino acid cleaving system 4 isoform e ...
PCSK6                 0.360   paired basic amino acid cleaving system 4 isoform f ...
PCSK6                 0.360   paired basic amino acid cleaving system 4 isoform d ...
PCSK1                 0.336   proprotein convertase subtilisin/kexin type 1 prepro...
PCSK2                 0.295   proprotein convertase subtilisin/kexin type 2 
PCSK6                 0.291   paired basic amino acid cleaving system 4 isoform c ...
PCSK7                 0.255   proprotein convertase subtilisin/kexin type 7 prepro...
FRAS1                 0.017   Fraser syndrome 1 
LOC100292811          0.014   PREDICTED: similar to proprotein convertase subtili...
LOC100290671          0.013   PREDICTED: hypothetical protein XP_002347099 
LOC100289618          0.013   PREDICTED: hypothetical protein XP_002342982 
CRELD2                0.008   cysteine-rich with EGF-like domains 2 isoform b [Ho...
CRELD2                0.006   cysteine-rich with EGF-like domains 2 isoform a [Ho...
SSPO                  0.006   SCO-spondin 
EGFR                  0.005   epidermal growth factor receptor isoform d precursor...
ERBB4                 0.004   v-erb-a erythroblastic leukemia viral oncogene homo...
ERBB4                 0.004   v-erb-a erythroblastic leukemia viral oncogene homolo...
LOC100293249          0.004   PREDICTED: similar to hCG2040393 
LOC100291245          0.004   PREDICTED: hypothetical protein XP_002347031 
LOC100287846          0.004   PREDICTED: hypothetical protein XP_002342883 
SLC18A3               0.004   vesicular acetylcholine transporter 
KCP                   0.004   cysteine rich BMP regulator 2 isoform 2 
PRSS12                0.004   neurotrypsin precursor 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
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