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Search of human proteins with 13899255
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13899255 membrane frizzled-related protein [Homo sapiens]
(579 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13899255 membrane frizzled-related protein [Homo sapiens] 1231 0.0
gi|6912724 tolloid-like 2 [Homo sapiens] 166 5e-41
gi|22547221 tolloid-like 1 [Homo sapiens] 160 2e-39
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 155 1e-37
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 154 3e-37
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 154 3e-37
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 152 1e-36
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 143 5e-34
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 130 3e-30
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 125 1e-28
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 125 1e-28
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 125 1e-28
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 123 4e-28
gi|126091152 cubilin [Homo sapiens] 123 5e-28
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 122 9e-28
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 122 1e-27
gi|167555125 low density lipoprotein receptor-related protein 3 ... 121 2e-27
gi|11415040 matriptase [Homo sapiens] 121 2e-27
gi|208973262 low density lipoprotein-related protein 12 isoform ... 121 2e-27
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 109 8e-24
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 109 8e-24
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 109 8e-24
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 109 8e-24
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 109 8e-24
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 109 8e-24
gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Ho... 107 4e-23
gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre... 102 7e-22
gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre... 102 7e-22
gi|29244926 corin [Homo sapiens] 97 5e-20
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 94 3e-19
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 1231 bits (3185), Expect = 0.0
Identities = 579/579 (100%), Positives = 579/579 (100%)
Query: 1 MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR 60
MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR
Sbjct: 1 MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR 60
Query: 61 PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT 120
PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT
Sbjct: 61 PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT 120
Query: 121 TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH 180
TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH
Sbjct: 121 TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH 180
Query: 181 AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS 240
AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS
Sbjct: 181 AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS 240
Query: 241 VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300
VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG
Sbjct: 241 VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE
Sbjct: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP
Sbjct: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN 480
CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN 480
Query: 481 TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS 540
TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS
Sbjct: 481 TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS 540
Query: 541 VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP 579
VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP
Sbjct: 541 VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP 579
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 166 bits (420), Expect = 5e-41
Identities = 106/326 (32%), Positives = 155/326 (47%), Gaps = 31/326 (9%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++TCGG ++ G SPNYPD Y P+ CVW I V+ + L +A IE SC +D
Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
LE+ P E L+ CG P + ++++ L + FVSD S+ GF A + +
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580
Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
P G C H RC + + G+ A D+ C CGG +T L GT
Sbjct: 581 SWPDHGGCEH---RCVNTLGSYKCACDPGYELAA---DKKMCEV---ACGGFITKLNGTI 631
Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
++P + ++YP C W + PA + I LQF F LE D CK+D+VEV S A L
Sbjct: 632 TSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDA-KL 690
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ--- 429
GRFCG+E P + S + + V F++D+ +S GF A F + ++ C CQ
Sbjct: 691 HGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRA---HFFSDKDECAKDNGGCQHEC 747
Query: 430 -------AGGCKGVQWMCDMWRDCTD 448
C+ W+ + DC +
Sbjct: 748 VNTFGSYLCRCRNGYWLHENGHDCKE 773
Score = 149 bits (377), Expect = 5e-36
Identities = 83/274 (30%), Positives = 141/274 (51%), Gaps = 14/274 (5%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG ++ G +SP +P YP N +CVW + + I L+ E +E C +D +E
Sbjct: 620 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVE 679
Query: 204 LSP--EPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ P+ L R CG P + + ++++ V F SD++V GF A + + + C
Sbjct: 680 VRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS---DKDEC 736
Query: 261 AHDEFRCD-QLICLLPDSVCDGFANCADGS--DETNCSAKFSGCGGNLTGLQGTFSTPSY 317
A D C + + +C C +G E K +GC ++ ++GT ++P++
Sbjct: 737 AKDNGGCQHECVNTFGSYLC----RCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNW 792
Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
+YP + CTW+IS AGH ++L F+ F +E EC +D++E+Y+ S A +LGRFC
Sbjct: 793 PDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLA-PILGRFC 851
Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
G++ P V+S + + F +D + GF A +
Sbjct: 852 GSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885
Score = 122 bits (306), Expect = 9e-28
Identities = 80/278 (28%), Positives = 114/278 (41%), Gaps = 55/278 (19%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ C +S G +SPN+PD YP C W+I H ++L IE C +D
Sbjct: 773 EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYD 832
Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
LE+ P+ P+L R CG P + S + + F SD+SV+ GF A +
Sbjct: 833 HLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHS------ 886
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
+ CGG L T S+
Sbjct: 887 -----------------------------------------TECGGRLKAEVQTKELYSH 905
Query: 318 LQ----QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
Q YP + C W I G+ +EL F F +E + +C +DY+E Y+ S A L
Sbjct: 906 AQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSA-PRL 964
Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
GRFCG+ P + S+ L + FRTD I+ GF A Y
Sbjct: 965 GRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 120 bits (301), Expect = 3e-27
Identities = 83/290 (28%), Positives = 125/290 (43%), Gaps = 55/290 (18%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG L G FS+P +P+ YP +HCVW I V I L ++ + C +D +E
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
+ + PLL R CG ++P P ++T+ S L V F S S++ G GF A Y+A
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTD-SRLWVEFRSSSNILGKGFFAAYEAT------ 463
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
CGG++ G +P+Y
Sbjct: 464 -----------------------------------------CGGDMNKDAGQIQSPNYPD 482
Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
Y C W I+V G + L F F +E D C +DY+EV + + + +L+G FCG
Sbjct: 483 DYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEES-ALIGHFCGY 541
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
E P + SS + L + F +D I+ GF+A + F + P C+
Sbjct: 542 EKPEDVKSSSNRLWMKFVSDGSINKAGFAANF--FKEVDECSWPDHGGCE 589
Score = 76.6 bits (187), Expect = 6e-14
Identities = 48/117 (41%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
K CG L G FS P + YP C W ISV G I L F + L C +
Sbjct: 347 KCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWY 406
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
DYVEV + A LLGRFCG + P LVS+ L V FR+ I GF A Y A
Sbjct: 407 DYVEVRDGYWRKA-PLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA 462
Score = 48.9 bits (115), Expect = 1e-05
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 7/126 (5%)
Query: 132 QESGVSPSPQSTCGGLLSGP---RGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
Q G + CGG L + +S + D YP C W I + ++L
Sbjct: 877 QRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFR 936
Query: 188 ALSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
+E A C +D +E + P L R CG P + + L++ F +D ++
Sbjct: 937 TFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKK 996
Query: 245 GFHAWY 250
GFHA Y
Sbjct: 997 GFHARY 1002
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 160 bits (406), Expect = 2e-39
Identities = 99/297 (33%), Positives = 146/297 (49%), Gaps = 21/297 (7%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG + G SPNYPD Y P CVW I V+ + + L ++ IE +C +D
Sbjct: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
LE+ PL+ R CG P + + ++ L + FVSD +V GF A + +
Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
P RG C E RC + L C G D +C A CGG LT L GT
Sbjct: 579 AKPDRGGC---EQRC---LNTLGSYQCACEPGYELGPDRRSCEA---ACGGLLTKLNGTI 629
Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
+TP + ++YP C W + P + I ++F F LE + CK+DYVE++ SS + L
Sbjct: 630 TTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES-KL 688
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
G+FCGAE P + S + + + F++D+ +S GF A F + ++ C CQ
Sbjct: 689 HGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKA---HFFSDKDECSKDNGGCQ 742
Score = 138 bits (347), Expect = 2e-32
Identities = 81/278 (29%), Positives = 141/278 (50%), Gaps = 12/278 (4%)
Query: 139 SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
S ++ CGGLL+ G ++P +P YPPN +CVW + T + I +K E +E C
Sbjct: 613 SCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCK 672
Query: 199 FDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAP 255
+D +E+ E L + CG P + + +++ + F SD++V GF A + +
Sbjct: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS--- 729
Query: 256 GRGSCAHDEFRCDQLICLLPDSVCDGFANCADG--SDETNCSAKFSGCGGNLTGLQGTFS 313
+ C+ D C Q C+ +++ C +G + K + C + G +
Sbjct: 730 DKDECSKDNGGC-QHECV--NTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLIT 786
Query: 314 TPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
+P++ +YP + CTW IS GH I+L F F +E EC +D++EV++ + + +L
Sbjct: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS-PIL 845
Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
GR CG + P LV++ +++ V F +D + GF AT+
Sbjct: 846 GRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
Score = 120 bits (300), Expect = 4e-27
Identities = 80/294 (27%), Positives = 124/294 (42%), Gaps = 58/294 (19%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG L G SSP +P+ YP THC+W + V I L + + + C +D +E
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 204 LSPE--PEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ + PLL R CG P L + S + + F S S+ G GF A Y+A+
Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI------- 461
Query: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
CGG + +G +P+Y
Sbjct: 462 ----------------------------------------CGGEIRKNEGQIQSPNYPDD 481
Query: 321 YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
Y C W I+V + + L F +F +E D C +DY+EV + +S + L+GRFCG +
Sbjct: 482 YRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENS-PLIGRFCGYD 540
Query: 381 PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCK 434
P + S+ + L + F +D ++ GF+A F E+ C + GGC+
Sbjct: 541 KPEDIRSTSNTLWMKFVSDGTVNKAGFAAN---FFKEEDECAKPD----RGGCE 587
Score = 119 bits (297), Expect = 1e-26
Identities = 79/274 (28%), Positives = 113/274 (41%), Gaps = 47/274 (17%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ C + P G +SPN+PD YP C W I H I+L IE C +D
Sbjct: 771 EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYD 830
Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
LE+ + P+L R+CG P L + + V FVSD+SV+ GF A +
Sbjct: 831 HLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH------- 883
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
+ C G + A+F G N
Sbjct: 884 ------------------STECGGRLKAESKPRDLYSHAQF---GDN------------- 909
Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
YP Q+ C W + G +EL F F +E + +C +DYVE+++ S A LGRFC
Sbjct: 910 --NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVG-LGRFC 966
Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
G+ PP + S + + F TD I+ GF Y
Sbjct: 967 GSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 7/129 (5%)
Query: 132 QESGVSPSPQSTCGGLL---SGPRGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
Q G + + CGG L S PR +S + D YP C W + ++L +
Sbjct: 875 QRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
Query: 188 ALSIESVASCLFDRLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
+E A C +D +EL + + R CG PP + + +L+ F +D ++
Sbjct: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKK 994
Query: 245 GFHAWYQAM 253
GFH Y+++
Sbjct: 995 GFHIRYKSI 1003
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 155 bits (392), Expect = 1e-37
Identities = 96/297 (32%), Positives = 142/297 (47%), Gaps = 21/297 (7%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG + G SPNYPD Y P+ C+W IQV+ + L ++ IE SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 201 RLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
LE+ E + R CG P + + +S L + FVSD S+ GF + +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
P RG C E RC + L C D+ C A CGG LT L G+
Sbjct: 552 SRPNRGGC---EQRC---LNTLGSYKCSCDPGYELAPDKRRCEA---ACGGFLTKLNGSI 602
Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
++P + ++YP C W + P + I LQF F E D CK+D+VEV + + L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
G+FCG+E P + S ++ + V F++D+ +S GF A F + ++ C CQ
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA---HFFSDKDECSKDNGGCQ 715
Score = 139 bits (349), Expect = 9e-33
Identities = 84/298 (28%), Positives = 145/298 (48%), Gaps = 40/298 (13%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG L+ G +SP +P YPPN +C+W + T + I L+ + E C +D
Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
Query: 201 RLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
+E+ + CG P + + +++ V F SD++V GF A + + +
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS---DK 704
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCAD--GSDETNCSAKF-----------SGCGGN 304
C+ D C Q +C + GS E C + F +GC
Sbjct: 705 DECSKDNGGCQQ--------------DCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHK 750
Query: 305 LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYET 364
+T GT ++P++ +YP + CTW IS GH ++L F +E+Q EC +D++EV++
Sbjct: 751 VTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDG 810
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
+ A +LGRFCG++ P ++++ + + F +D+ + GF A++ ATE CG
Sbjct: 811 RDAKA-PVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH----ATE--CG 861
Score = 117 bits (293), Expect = 3e-26
Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG L G FSSP YP+ Y + HCVW I V I L +L + C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
+ + PL R CG ++P P ++T+ S L V F S S+ G GF A Y+A+
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
CGG++ G +P+Y
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453
Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
Y +C W I V G + L F +F +E D C +DY+EV + S + +L+GR+CG
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
E P + S+ L + F +D I+ GF+ + F + P+ C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560
Score = 109 bits (273), Expect = 6e-24
Identities = 74/278 (26%), Positives = 115/278 (41%), Gaps = 55/278 (19%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ C ++ G +SPN+PD YP C W I H ++L + IES C +D
Sbjct: 744 EAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYD 803
Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
LE+ + + P+L R CG P + S + + F SD+SV+ GF A
Sbjct: 804 HLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQA--------- 854
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
+ + CGG + T S+
Sbjct: 855 --------------------------------------SHATECGGQVRADVKTKDLYSH 876
Query: 318 LQ----QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
Q YP + C W I G+ +EL F F +E + +C +DY+E+++ S A L
Sbjct: 877 AQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTA-PRL 935
Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
GR+CG+ PP + S+ + V F +D I+ GF Y
Sbjct: 936 GRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
K CG L G FS+P Y Y + C W ISV G I L F + L C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
DYVEV + A L GRFCG++ P +VS+ L V FR+ GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/126 (27%), Positives = 53/126 (42%), Gaps = 7/126 (5%)
Query: 132 QESGVSPSPQSTCGGLLSGP---RGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
Q G S + CGG + + +S + D YP C W I + ++L +
Sbjct: 848 QRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQ 907
Query: 188 ALSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
+E C +D +EL + P L R CG PP + + +LV F SD ++
Sbjct: 908 TFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKK 967
Query: 245 GFHAWY 250
GFH Y
Sbjct: 968 GFHLRY 973
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 154 bits (388), Expect = 3e-37
Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG + G SPNYPD Y P+ C+W IQV+ + L ++ IE SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
LE+ E + R CG P + + +S L + FVSD S+ GF + +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
P RG C E RC + S G+ D + C A CGG LT L G+
Sbjct: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602
Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
++P + ++YP C W + P + I LQF F E D CK+D+VEV + + L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
G+FCG+E P + S ++ + V F++D+ +S GF A + +
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 117 bits (293), Expect = 3e-26
Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG L G FSSP YP+ Y + HCVW I V I L +L + C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
+ + PL R CG ++P P ++T+ S L V F S S+ G GF A Y+A+
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
CGG++ G +P+Y
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453
Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
Y +C W I V G + L F +F +E D C +DY+EV + S + +L+GR+CG
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
E P + S+ L + F +D I+ GF+ + F + P+ C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
K CG L G FS+P Y Y + C W ISV G I L F + L C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
DYVEV + A L GRFCG++ P +VS+ L V FR+ GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 154 bits (388), Expect = 3e-37
Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG + G SPNYPD Y P+ C+W IQV+ + L ++ IE SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
LE+ E + R CG P + + +S L + FVSD S+ GF + +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
P RG C E RC + S G+ D + C A CGG LT L G+
Sbjct: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602
Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
++P + ++YP C W + P + I LQF F E D CK+D+VEV + + L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
G+FCG+E P + S ++ + V F++D+ +S GF A + +
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 117 bits (293), Expect = 3e-26
Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG L G FSSP YP+ Y + HCVW I V I L +L + C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
+ + PL R CG ++P P ++T+ S L V F S S+ G GF A Y+A+
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
CGG++ G +P+Y
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453
Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
Y +C W I V G + L F +F +E D C +DY+EV + S + +L+GR+CG
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
E P + S+ L + F +D I+ GF+ + F + P+ C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
K CG L G FS+P Y Y + C W ISV G I L F + L C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
DYVEV + A L GRFCG++ P +VS+ L V FR+ GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
Score = 67.4 bits (163), Expect = 3e-11
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG L+ G +SP +P YPPN +C+W + T + I L+ + E C +D
Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
Query: 201 RLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
+E+ + CG P + + +++ V F SD++V GF A + ++ G
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
Query: 258 G 258
G
Sbjct: 708 G 708
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 152 bits (383), Expect = 1e-36
Identities = 96/280 (34%), Positives = 125/280 (44%), Gaps = 55/280 (19%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+LS P G FSSPN+P YP NT C W I VA ++ L A +E +C FD LE
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 204 L----SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
+ SP+ L R CG+VPPP ++ + V+F SD V GF A YQ
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK------- 142
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
CGG LTGL G ++P Y
Sbjct: 143 ---------------------------------------DVCGGVLTGLSGVLTSPEYPN 163
Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG-RFCG 378
YP+ + C W I ++L F +F +E +EC +DYV V G G +CG
Sbjct: 164 NYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL----GGPGPTRGHHYCG 219
Query: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+ PP LVS HEL V+F++D I GF A Y + E
Sbjct: 220 STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
Score = 128 bits (322), Expect = 1e-29
Identities = 86/302 (28%), Positives = 130/302 (43%), Gaps = 66/302 (21%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
+ CGG+L+G G +SP YP+ YP + C W I+ A ++L +E C +D
Sbjct: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
Query: 201 RLELSPEPEGPLL--RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
+ + P GP CG PPTL + L VVF SD ++ G GF A+Y
Sbjct: 202 YVAVLGGP-GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY-------- 252
Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG-CGGNLTGLQGTFSTPSY 317
FSG C ++G FS+P Y
Sbjct: 253 ---------------------------------------FSGECQEVYMAMRGNFSSPQY 273
Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE----CKFDYVEVYETSSSGAFSLL 373
YP+ + C W I +P G+ +++ F + LE + C FD++ ++ +S A LL
Sbjct: 274 PSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEA-PLL 332
Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGC 433
G +CG PP + SSH++L +L TD + GFS Y+ +L C +G
Sbjct: 333 GNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG----------GQLGCGSGST 382
Query: 434 KG 435
+G
Sbjct: 383 EG 384
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 143 bits (360), Expect = 5e-34
Identities = 87/292 (29%), Positives = 133/292 (45%), Gaps = 43/292 (14%)
Query: 124 AAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQ 183
AA T +Q+S P TCGG+L+G GF S +P YPPN+ C W I V +
Sbjct: 15 AAATQLSRQQS--PERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVV 72
Query: 184 LKIEALSIESVASCLFDRLEL-SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSV 241
L + +ES C +D +++ + G + R CG P L ++ + ++V +SD++
Sbjct: 73 LNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
Query: 242 EGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGC 301
G GF A + A P R DQ C
Sbjct: 133 AGNGFMAMFSAAEPNE--------RGDQY------------------------------C 154
Query: 302 GGNLTGLQGTFSTPSYL-QQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
GG L G+F TP++ + YP + C WHI P IEL+F F +E + C++DYV
Sbjct: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYL 412
V+ +G++CG PP +VS +EL + F +D +++ GF Y+
Sbjct: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
Score = 82.0 bits (201), Expect = 1e-15
Identities = 49/141 (34%), Positives = 69/141 (48%), Gaps = 6/141 (4%)
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGG LTG G + + YP CTW I+VP G + L F LE+ + C++D+V+
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
VY ++G +GRFCG P LVSS +++ V +D + GF A + A E
Sbjct: 93 VYNGHANG--QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
Query: 421 ---CGPSELSCQAGGCKGVQW 438
CG L +G K W
Sbjct: 151 DQYCG-GLLDRPSGSFKTPNW 170
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 130 bits (328), Expect = 3e-30
Identities = 89/311 (28%), Positives = 127/311 (40%), Gaps = 46/311 (14%)
Query: 105 LPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY 164
LPA T + P +T A P Q ++ P CGG + G G+ +S +P+ Y
Sbjct: 2 LPAA--TASLLGPLLTA--CALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLY 57
Query: 165 PPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL---SPEPEGPLLRVCGRVPP 221
PPN C+W I V + L +E +C +D LE+ S L R CG P
Sbjct: 58 PPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP 117
Query: 222 PTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDG 281
L + + + +D G GF WY A
Sbjct: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS------------------------- 152
Query: 282 FANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ-YPHQLLCTWHISVPAGHSIE 340
+ CGG L QGT +TP++ + YP + C+WHI P I
Sbjct: 153 -------------GTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIA 199
Query: 341 LQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
L F F LE C++D V V+ + S LG+FCG P + S +EL V F +D
Sbjct: 200 LTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDL 259
Query: 401 GISSGGFSATY 411
+++ GFSA+Y
Sbjct: 260 SVTADGFSASY 270
Score = 76.3 bits (186), Expect = 7e-14
Identities = 43/125 (34%), Positives = 63/125 (50%), Gaps = 4/125 (3%)
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGG++ G G ++ + YP C W I+VP G ++ L F F LE C++D +E
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY--LAFNATE 418
V+ S + LGRFCG P LV+ +++ + TD G GF Y A + TE
Sbjct: 97 VFAGSGTSG-QRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
Query: 419 NP-CG 422
+ CG
Sbjct: 156 HQFCG 160
Score = 73.9 bits (180), Expect = 4e-13
Identities = 48/159 (30%), Positives = 69/159 (43%), Gaps = 5/159 (3%)
Query: 103 SPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPD 162
+PL A G T T + G S + CGG L +G ++PN+P+
Sbjct: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE 177
Query: 163 P-YPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELS----PEPEGPLLRVCG 217
YPP C WHI D I L E +E C +D + + + L + CG
Sbjct: 178 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCG 237
Query: 218 RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
P ++++ + LLV FVSD SV GF A Y+ + G
Sbjct: 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 125 bits (313), Expect = 1e-28
Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+L+ +G SP YP+PY N +CVW I V IQ+++ + + E L D +
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1957
Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
L G P LN+ +++L + F SD SV GFH Y A+ G SC
Sbjct: 1958 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 2015
Query: 264 E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
+ F+CDQ L S C G C A+
Sbjct: 2016 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2070
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG ++ G +P + YP L CTW I++P G + LQF NFS E DY
Sbjct: 2071 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+EV + SS +++GR G + P L S+ HE ++ F +D+ + GF Y A+
Sbjct: 2125 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183
Query: 419 NP 420
P
Sbjct: 2184 CP 2185
Score = 117 bits (293), Expect = 3e-26
Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
TCG L GP G F+SPN+P Y N CVW I V T+ IQ+ E +E +D
Sbjct: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562
Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
L + +P L + G P + + +S + + +D SV GF Y+ +
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 620
Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
+ SC D L DGF+N C G + N
Sbjct: 621 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 674
Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
C N T GT +P Y + Y + L C W I G I L F++F LE+Q
Sbjct: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 731
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
FD++ V + S + +LG F GAE P HL S+ H L + F+ DH +S GF+ TY F
Sbjct: 732 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 789
Query: 415 NATENP 420
E P
Sbjct: 790 GHNECP 795
Score = 108 bits (271), Expect = 1e-23
Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)
Query: 99 GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
G+S S + G T T TIT G SG+ P + CGG S P G SP
Sbjct: 813 GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 869
Query: 159 NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
+P Y + +C W I+ H+I++ E E +D LE+ P PLL
Sbjct: 870 GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 925
Query: 216 CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
G P L ++++ + ++F +D+S GF Y+++ SC HD
Sbjct: 926 NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 985
Query: 264 -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
F CD L + N C A CGG++ G GT +P
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 1042
Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
Y + YP+ L CTW + V G ++ FH F LE DY+ + E +G+F+ L R
Sbjct: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1095
Query: 376 FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
G++ PP + + + + F +D IS GF+ T+ +N PC
Sbjct: 1096 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1142
Score = 99.8 bits (247), Expect = 6e-21
Identities = 84/308 (27%), Positives = 125/308 (40%), Gaps = 38/308 (12%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
TCGG L G G SP +P YP +C W I + IQ+ ++ ++E +D L
Sbjct: 24 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 79
Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
L P P R+ G PP + + S + SD +V GF +Y+ +
Sbjct: 80 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139
Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
P +G F I + + DG ++ N C A+
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 198
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG + G G S+PS+ +Y + CTW I G +I L F +F +E K+DY
Sbjct: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 254
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+E+ E S L G PP ++S+ + L + F TD GFSA Y +
Sbjct: 255 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309
Query: 419 NPCGPSEL 426
+ EL
Sbjct: 310 HTTSTGEL 317
Score = 99.0 bits (245), Expect = 1e-20
Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
C + P G SP+YP+ Y N +C+W I I L +ES FD L
Sbjct: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 736
Query: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ PE P+L P+ T+ SH+L + F +D S+ G GF+ Y G C
Sbjct: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 794
Query: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
D F+ I ++ + +GF G++ C +SG
Sbjct: 795 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 850
Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
CGG+ + G +P + Y L C W I GHSI++ F F Q E +
Sbjct: 851 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 906
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
D +EV++ + LLG + G + P L SS + + +LF TD+ S+ GF Y +
Sbjct: 907 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 965
Query: 417 TENPC 421
C
Sbjct: 966 NTYSC 970
Score = 93.6 bits (231), Expect = 4e-19
Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)
Query: 138 PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
PSP + CGG L+G GF SPN+P PYP + C W I V D+ I L + SIE
Sbjct: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1598
Query: 195 ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
L+ + P+ PL+ P + ++++ + + F SD SV GFH Y+A
Sbjct: 1599 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656
Query: 253 -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
PG G+ +++ + D+ V G++ C G D
Sbjct: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 293 NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
+C A CG TG +GT +P+Y + Y C + I+VP + QF F
Sbjct: 1717 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1772
Query: 353 ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
D VEVY+ SS SL G G P +SS +++ + F + I++ GF
Sbjct: 1773 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1825
Query: 410 TYLAFNATEN 419
Y A T +
Sbjct: 1826 VYQAVPRTSS 1835
Score = 89.4 bits (220), Expect = 8e-18
Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P ++ CGG ++ G SP YPD YP C W ++V + I + L E +
Sbjct: 2237 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2295
Query: 198 LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
F + P+ P + + G ++ + ++ +L+ F SD + GF +HA+
Sbjct: 2296 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2354
Query: 251 -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
Q P + DEF +I LP G A C DG+ C
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2413
Query: 296 AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
C N L G +P Y YP+ +C W ISV G++I + F Q E
Sbjct: 2414 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2466
Query: 354 CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
+FD ++VY+ S SL G + A ++ S+ HE+ + + DHG + GF
Sbjct: 2467 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2523
Query: 411 YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
Y+AF + P + Q GG V+W CD
Sbjct: 2524 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2557
Score = 77.8 bits (190), Expect = 3e-14
Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P+ + CGG + GP G SP YP+ YP + +C W + V +Q +E
Sbjct: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080
Query: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
L + + PL R+ G PPT+N + F+SD S+ GF+ +
Sbjct: 1081 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138
Query: 254 --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
P GS F + S +C G + C
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A+ CG + T +G +P+Y Y + C + I V AG I + F L +
Sbjct: 1199 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1250
Query: 356 FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
D +++Y+ LLG F GA L S+ ++L + F +D + GF Y +F
Sbjct: 1251 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1309
Score = 62.0 bits (149), Expect = 1e-09
Identities = 39/136 (28%), Positives = 62/136 (45%), Gaps = 7/136 (5%)
Query: 290 DETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
D S CGG L GL GT +P + YP+ CTW I + I++ F +F+LE
Sbjct: 14 DRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE 73
Query: 350 AQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
+ +DY+ +Y+ + R G PP + S+ ++ +D +S+ GF
Sbjct: 74 EE----YDYLSLYD-GHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV 128
Query: 410 TY--LAFNATENPCGP 423
Y L ++ NP P
Sbjct: 129 YYEELQSSSCGNPGVP 144
Score = 61.6 bits (148), Expect = 2e-09
Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
P + CG + G SPNYP Y N C++ IQV I + + +
Sbjct: 1195 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1254
Query: 197 CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
++D + + G R TL++ ++ L + F SD+ GF Y +
Sbjct: 1255 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1312
Query: 255 -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
P G D+ + C+ L S+ C G
Sbjct: 1313 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1368
Query: 293 NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
+C A+ CGG G G +P Y Y + L C W I V G+ + LQF F EA
Sbjct: 1369 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1424
Query: 352 DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
D + V++ LL G+ P + S+ + + + F TD IS GF+ +
Sbjct: 1425 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480
Query: 412 LAFNAT 417
+ AT
Sbjct: 1481 SSSVAT 1486
Score = 57.8 bits (138), Expect = 3e-08
Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
+ CGG + G G SSP++P+ Y N C W I I L +E +D
Sbjct: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253
Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
LE+ E P + + G PP + +N + L + FV+DS+ GF A YQ
Sbjct: 254 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 8/152 (5%)
Query: 264 EFRCDQLICL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQY 321
+F CD+ L C A + K CG NL G GTF++P++ QY
Sbjct: 469 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQY 528
Query: 322 PHQLLCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGA 379
C W I +V I++ F F L E +D + + + G ++L G+
Sbjct: 529 DSNAQCVWVITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGS 584
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
P +VS ++ + +TD + S GF Y
Sbjct: 585 FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 616
Score = 36.2 bits (82), Expect = 0.085
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)
Query: 132 QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
Q G P Q C L G SP YPD YP C W I V + I + +E
Sbjct: 2404 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2463
Query: 190 SIESVASCLFDRLEL--SPEPEGPLL 213
E FD L++ P + P+L
Sbjct: 2464 QTEKE----FDVLQVYDGPNIQSPVL 2485
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 125 bits (313), Expect = 1e-28
Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+L+ +G SP YP+PY N +CVW I V IQ+++ + + E L D +
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1893
Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
L G P LN+ +++L + F SD SV GFH Y A+ G SC
Sbjct: 1894 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 1951
Query: 264 E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
+ F+CDQ L S C G C A+
Sbjct: 1952 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2006
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG ++ G +P + YP L CTW I++P G + LQF NFS E DY
Sbjct: 2007 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2060
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+EV + SS +++GR G + P L S+ HE ++ F +D+ + GF Y A+
Sbjct: 2061 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2119
Query: 419 NP 420
P
Sbjct: 2120 CP 2121
Score = 117 bits (293), Expect = 3e-26
Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
TCG L GP G F+SPN+P Y N CVW I V T+ IQ+ E +E +D
Sbjct: 443 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 498
Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
L + +P L + G P + + +S + + +D SV GF Y+ +
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 556
Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
+ SC D L DGF+N C G + N
Sbjct: 557 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 610
Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
C N T GT +P Y + Y + L C W I G I L F++F LE+Q
Sbjct: 611 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 667
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
FD++ V + S + +LG F GAE P HL S+ H L + F+ DH +S GF+ TY F
Sbjct: 668 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 725
Query: 415 NATENP 420
E P
Sbjct: 726 GHNECP 731
Score = 108 bits (271), Expect = 1e-23
Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)
Query: 99 GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
G+S S + G T T TIT G SG+ P + CGG S P G SP
Sbjct: 749 GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 805
Query: 159 NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
+P Y + +C W I+ H+I++ E E +D LE+ P PLL
Sbjct: 806 GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 861
Query: 216 CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
G P L ++++ + ++F +D+S GF Y+++ SC HD
Sbjct: 862 NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 921
Query: 264 -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
F CD L + N C A CGG++ G GT +P
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 978
Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
Y + YP+ L CTW + V G ++ FH F LE DY+ + E +G+F+ L R
Sbjct: 979 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1031
Query: 376 FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
G++ PP + + + + F +D IS GF+ T+ +N PC
Sbjct: 1032 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1078
Score = 99.0 bits (245), Expect = 1e-20
Identities = 82/293 (27%), Positives = 121/293 (41%), Gaps = 38/293 (12%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
TCGG L G G SP +P YP +C W I + IQ+ ++ ++E +D L
Sbjct: 64 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119
Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
L P P R+ G PP + + S + SD +V GF +Y+ +
Sbjct: 120 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
P +G F I + + DG ++ N C A+
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 238
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG + G G S+PS+ +Y + CTW I G +I L F +F +E K+DY
Sbjct: 239 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 294
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
+E+ E S L G PP ++S+ + L + F TD GFSA Y
Sbjct: 295 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 99.0 bits (245), Expect = 1e-20
Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
C + P G SP+YP+ Y N +C+W I I L +ES FD L
Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 672
Query: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ PE P+L P+ T+ SH+L + F +D S+ G GF+ Y G C
Sbjct: 673 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 730
Query: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
D F+ I ++ + +GF G++ C +SG
Sbjct: 731 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 786
Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
CGG+ + G +P + Y L C W I GHSI++ F F Q E +
Sbjct: 787 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 842
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
D +EV++ + LLG + G + P L SS + + +LF TD+ S+ GF Y +
Sbjct: 843 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 901
Query: 417 TENPC 421
C
Sbjct: 902 NTYSC 906
Score = 93.6 bits (231), Expect = 4e-19
Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)
Query: 138 PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
PSP + CGG L+G GF SPN+P PYP + C W I V D+ I L + SIE
Sbjct: 1475 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1534
Query: 195 ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
L+ + P+ PL+ P + ++++ + + F SD SV GFH Y+A
Sbjct: 1535 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1592
Query: 253 -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
PG G+ +++ + D+ V G++ C G D
Sbjct: 1593 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 293 NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
+C A CG TG +GT +P+Y + Y C + I+VP + QF F
Sbjct: 1653 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1708
Query: 353 ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
D VEVY+ SS SL G G P +SS +++ + F + I++ GF
Sbjct: 1709 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1761
Query: 410 TYLAFNATEN 419
Y A T +
Sbjct: 1762 VYQAVPRTSS 1771
Score = 89.4 bits (220), Expect = 8e-18
Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P ++ CGG ++ G SP YPD YP C W ++V + I + L E +
Sbjct: 2173 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2231
Query: 198 LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
F + P+ P + + G ++ + ++ +L+ F SD + GF +HA+
Sbjct: 2232 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2290
Query: 251 -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
Q P + DEF +I LP G A C DG+ C
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2349
Query: 296 AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
C N L G +P Y YP+ +C W ISV G++I + F Q E
Sbjct: 2350 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2402
Query: 354 CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
+FD ++VY+ S SL G + A ++ S+ HE+ + + DHG + GF
Sbjct: 2403 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2459
Query: 411 YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
Y+AF + P + Q GG V+W CD
Sbjct: 2460 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2493
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/324 (24%), Positives = 121/324 (37%), Gaps = 62/324 (19%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
+ CGG + G G SSP++P+ Y N C W I I L +E +D
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA-------- 252
LE+ E P + + G PP + +N + L + FV+DS+ GF A YQ
Sbjct: 294 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKS 352
Query: 253 ----MAPGRGSC-------------------------------------AHDEFRCDQLI 271
+ PG+ + + +F CD+
Sbjct: 353 RGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDY 412
Query: 272 CL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
L C A + K CG NL G GTF++P++ QY C W
Sbjct: 413 VLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVW 472
Query: 330 HI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPPHLVS 387
I +V I++ F F L E +D + + + G ++L G+ P +VS
Sbjct: 473 VITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528
Query: 388 SHHELAVLFRTDHGISSGGFSATY 411
++ + +TD + S GF Y
Sbjct: 529 MSSQMWLHLQTDESVGSVGFKVNY 552
Score = 77.8 bits (190), Expect = 3e-14
Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P+ + CGG + GP G SP YP+ YP + +C W + V +Q +E
Sbjct: 957 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1016
Query: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
L + + PL R+ G PPT+N + F+SD S+ GF+ +
Sbjct: 1017 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074
Query: 254 --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
P GS F + S +C G + C
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A+ CG + T +G +P+Y Y + C + I V AG I + F L +
Sbjct: 1135 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1186
Query: 356 FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
D +++Y+ LLG F GA L S+ ++L + F +D + GF Y +F
Sbjct: 1187 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1245
Score = 61.6 bits (148), Expect = 2e-09
Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
P + CG + G SPNYP Y N C++ IQV I + + +
Sbjct: 1131 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1190
Query: 197 CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
++D + + G R TL++ ++ L + F SD+ GF Y +
Sbjct: 1191 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1248
Query: 255 -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
P G D+ + C+ L S+ C G
Sbjct: 1249 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1304
Query: 293 NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
+C A+ CGG G G +P Y Y + L C W I V G+ + LQF F EA
Sbjct: 1305 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1360
Query: 352 DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
D + V++ LL G+ P + S+ + + + F TD IS GF+ +
Sbjct: 1361 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1416
Query: 412 LAFNAT 417
+ AT
Sbjct: 1417 SSSVAT 1422
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 7/125 (5%)
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGG L GL GT +P + YP+ CTW I + I++ F +F+LE + +DY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY--LAFNATE 418
+Y+ + R G PP + S+ ++ +D +S+ GF Y L ++
Sbjct: 121 LYD-GHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 419 NPCGP 423
NP P
Sbjct: 180 NPGVP 184
Score = 36.2 bits (82), Expect = 0.085
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)
Query: 132 QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
Q G P Q C L G SP YPD YP C W I V + I + +E
Sbjct: 2340 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2399
Query: 190 SIESVASCLFDRLEL--SPEPEGPLL 213
E FD L++ P + P+L
Sbjct: 2400 QTEKE----FDVLQVYDGPNIQSPVL 2421
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 125 bits (313), Expect = 1e-28
Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+L+ +G SP YP+PY N +CVW I V IQ+++ + + E L D +
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1997
Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
L G P LN+ +++L + F SD SV GFH Y A+ G SC
Sbjct: 1998 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 2055
Query: 264 E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
+ F+CDQ L S C G C A+
Sbjct: 2056 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2110
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG ++ G +P + YP L CTW I++P G + LQF NFS E DY
Sbjct: 2111 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2164
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+EV + SS +++GR G + P L S+ HE ++ F +D+ + GF Y A+
Sbjct: 2165 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2223
Query: 419 NP 420
P
Sbjct: 2224 CP 2225
Score = 117 bits (293), Expect = 3e-26
Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
TCG L GP G F+SPN+P Y N CVW I V T+ IQ+ E +E +D
Sbjct: 547 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 602
Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
L + +P L + G P + + +S + + +D SV GF Y+ +
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 660
Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
+ SC D L DGF+N C G + N
Sbjct: 661 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 714
Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
C N T GT +P Y + Y + L C W I G I L F++F LE+Q
Sbjct: 715 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 771
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
FD++ V + S + +LG F GAE P HL S+ H L + F+ DH +S GF+ TY F
Sbjct: 772 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 829
Query: 415 NATENP 420
E P
Sbjct: 830 GHNECP 835
Score = 108 bits (271), Expect = 1e-23
Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)
Query: 99 GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
G+S S + G T T TIT G SG+ P + CGG S P G SP
Sbjct: 853 GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 909
Query: 159 NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
+P Y + +C W I+ H+I++ E E +D LE+ P PLL
Sbjct: 910 GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 965
Query: 216 CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
G P L ++++ + ++F +D+S GF Y+++ SC HD
Sbjct: 966 NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 1025
Query: 264 -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
F CD L + N C A CGG++ G GT +P
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 1082
Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
Y + YP+ L CTW + V G ++ FH F LE DY+ + E +G+F+ L R
Sbjct: 1083 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1135
Query: 376 FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
G++ PP + + + + F +D IS GF+ T+ +N PC
Sbjct: 1136 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1182
Score = 99.8 bits (247), Expect = 6e-21
Identities = 84/308 (27%), Positives = 125/308 (40%), Gaps = 38/308 (12%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
TCGG L G G SP +P YP +C W I + IQ+ ++ ++E +D L
Sbjct: 64 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119
Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
L P P R+ G PP + + S + SD +V GF +Y+ +
Sbjct: 120 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
P +G F I + + DG ++ N C A+
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 238
Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
CGG + G G S+PS+ +Y + CTW I G +I L F +F +E K+DY
Sbjct: 239 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 294
Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+E+ E S L G PP ++S+ + L + F TD GFSA Y +
Sbjct: 295 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 349
Query: 419 NPCGPSEL 426
+ EL
Sbjct: 350 HTTSTGEL 357
Score = 99.0 bits (245), Expect = 1e-20
Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
C + P G SP+YP+ Y N +C+W I I L +ES FD L
Sbjct: 721 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 776
Query: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ PE P+L P+ T+ SH+L + F +D S+ G GF+ Y G C
Sbjct: 777 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 834
Query: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
D F+ I ++ + +GF G++ C +SG
Sbjct: 835 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 890
Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
CGG+ + G +P + Y L C W I GHSI++ F F Q E +
Sbjct: 891 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 946
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
D +EV++ + LLG + G + P L SS + + +LF TD+ S+ GF Y +
Sbjct: 947 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 1005
Query: 417 TENPC 421
C
Sbjct: 1006 NTYSC 1010
Score = 93.6 bits (231), Expect = 4e-19
Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)
Query: 138 PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
PSP + CGG L+G GF SPN+P PYP + C W I V D+ I L + SIE
Sbjct: 1579 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1638
Query: 195 ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
L+ + P+ PL+ P + ++++ + + F SD SV GFH Y+A
Sbjct: 1639 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1696
Query: 253 -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
PG G+ +++ + D+ V G++ C G D
Sbjct: 1697 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 293 NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
+C A CG TG +GT +P+Y + Y C + I+VP + QF F
Sbjct: 1757 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1812
Query: 353 ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
D VEVY+ SS SL G G P +SS +++ + F + I++ GF
Sbjct: 1813 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1865
Query: 410 TYLAFNATEN 419
Y A T +
Sbjct: 1866 VYQAVPRTSS 1875
Score = 89.4 bits (220), Expect = 8e-18
Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P ++ CGG ++ G SP YPD YP C W ++V + I + L E +
Sbjct: 2277 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2335
Query: 198 LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
F + P+ P + + G ++ + ++ +L+ F SD + GF +HA+
Sbjct: 2336 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2394
Query: 251 -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
Q P + DEF +I LP G A C DG+ C
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2453
Query: 296 AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
C N L G +P Y YP+ +C W ISV G++I + F Q E
Sbjct: 2454 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2506
Query: 354 CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
+FD ++VY+ S SL G + A ++ S+ HE+ + + DHG + GF
Sbjct: 2507 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2563
Query: 411 YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
Y+AF + P + Q GG V+W CD
Sbjct: 2564 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2597
Score = 77.8 bits (190), Expect = 3e-14
Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P+ + CGG + GP G SP YP+ YP + +C W + V +Q +E
Sbjct: 1061 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1120
Query: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
L + + PL R+ G PPT+N + F+SD S+ GF+ +
Sbjct: 1121 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178
Query: 254 --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
P GS F + S +C G + C
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A+ CG + T +G +P+Y Y + C + I V AG I + F L +
Sbjct: 1239 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1290
Query: 356 FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
D +++Y+ LLG F GA L S+ ++L + F +D + GF Y +F
Sbjct: 1291 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1349
Score = 61.6 bits (148), Expect = 2e-09
Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
P + CG + G SPNYP Y N C++ IQV I + + +
Sbjct: 1235 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1294
Query: 197 CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
++D + + G R TL++ ++ L + F SD+ GF Y +
Sbjct: 1295 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1352
Query: 255 -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
P G D+ + C+ L S+ C G
Sbjct: 1353 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1408
Query: 293 NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
+C A+ CGG G G +P Y Y + L C W I V G+ + LQF F EA
Sbjct: 1409 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1464
Query: 352 DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
D + V++ LL G+ P + S+ + + + F TD IS GF+ +
Sbjct: 1465 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1520
Query: 412 LAFNAT 417
+ AT
Sbjct: 1521 SSSVAT 1526
Score = 57.8 bits (138), Expect = 3e-08
Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
+ CGG + G G SSP++P+ Y N C W I I L +E +D
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
LE+ E P + + G PP + +N + L + FV+DS+ GF A YQ
Sbjct: 294 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 8/152 (5%)
Query: 264 EFRCDQLICL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQY 321
+F CD+ L C A + K CG NL G GTF++P++ QY
Sbjct: 509 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQY 568
Query: 322 PHQLLCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGA 379
C W I +V I++ F F L E +D + + + G ++L G+
Sbjct: 569 DSNAQCVWVITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGS 624
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
P +VS ++ + +TD + S GF Y
Sbjct: 625 FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 656
Score = 36.2 bits (82), Expect = 0.085
Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)
Query: 132 QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
Q G P Q C L G SP YPD YP C W I V + I + +E
Sbjct: 2444 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2503
Query: 190 SIESVASCLFDRLEL--SPEPEGPLL 213
E FD L++ P + P+L
Sbjct: 2504 QTEKE----FDVLQVYDGPNIQSPVL 2525
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 123 bits (309), Expect = 4e-28
Identities = 88/301 (29%), Positives = 137/301 (45%), Gaps = 42/301 (13%)
Query: 137 SPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS 196
+P+ CGG L+ RG SP +P+PY + +CVW I V IQ+++ + V
Sbjct: 1789 APTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQV----VSFVTE 1844
Query: 197 CLFDRLELSPEPEGPLLRV---CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM 253
+D LE+ + + + G P LN+ ++ L + F SD SV GFH Y+ +
Sbjct: 1845 QNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Query: 254 A---------PGRGSCAHDEFRCDQLICLL--PDSVCDGFAN--CADGS------DETNC 294
P G + + + ++ P G A+ C G+ C
Sbjct: 1905 GLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
A+ CGG + ++G +P + YP + C+W I++P G +QF NFS E
Sbjct: 1965 IAQ---CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEP---- 2017
Query: 355 KFDYVEV----YETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
DY+E+ YETS ++GRF G+E P L+S+ HE V F +DH + GF
Sbjct: 2018 NHDYIEIRNGPYETS-----RMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLE 2072
Query: 411 Y 411
Y
Sbjct: 2073 Y 2073
Score = 110 bits (274), Expect = 5e-24
Identities = 95/309 (30%), Positives = 134/309 (43%), Gaps = 40/309 (12%)
Query: 128 PKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE 187
P+ Q +S S C L GP G SP +P YP +C W I H IQL +
Sbjct: 10 PRWQVQSHHPRSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQ 69
Query: 188 ALSIESVASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
+ ++E FD L + P+PE R+ G P T+ + A+ L + +SD +V
Sbjct: 70 SFALEED----FDVLSVFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQ 125
Query: 245 GFHAWYQAMA------PGR---GSCAHDEFRCDQLI---CLLPDSVCDGFA--NCADGSD 290
GFHA Y+ + PGR G F + C L +G A C GS+
Sbjct: 126 GFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNL-GFFLEGHAVLTCHAGSE 184
Query: 291 ET--------NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQ 342
+ +C A CGG L G G S+P + +Y + CTW I G +I L
Sbjct: 185 NSATWDFPLPSCRAD-DACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALV 243
Query: 343 FHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGI 402
F +F LE +D++EV T S + F GA P ++SS + L + F +D
Sbjct: 244 FIDFQLED----GYDFLEVTGTEGSSLW-----FTGASLPAPVISSKNWLRLHFTSDGNH 294
Query: 403 SSGGFSATY 411
GFSA Y
Sbjct: 295 RQRGFSAQY 303
Score = 102 bits (253), Expect = 1e-21
Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 41/307 (13%)
Query: 138 PSPQSTCGGLLSGP-RGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS 196
P+ + CGG + G G SP YP PY N +C+W I+ I L E V
Sbjct: 1265 PTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHD 1324
Query: 197 CLFDRLELSPEPEGPLLR-VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA- 254
L R+ P G LL+ + G P L++ + +++ F +D GF +
Sbjct: 1325 VL--RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTA 1382
Query: 255 --------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC------------ 294
P GS + D + D G+A GS E +C
Sbjct: 1383 TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDP---GYA--LQGSAEISCVKIENRFFWQPS 1437
Query: 295 -SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
+ CGG+LTG G +P+Y + YP C W ++V + I L F+ F+LE
Sbjct: 1438 PPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP--- 1494
Query: 354 CKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
+D++ +Y+ S L+G F G++ P + SS + L + FR+D +S+ GF Y
Sbjct: 1495 -GYDFLHIYDGRDS-LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY-- 1550
Query: 414 FNATENP 420
TENP
Sbjct: 1551 ---TENP 1554
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/296 (26%), Positives = 118/296 (39%), Gaps = 27/296 (9%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIESVASCLFDRL 202
C L GP G +SPN+P Y N HCVW I I+L E +E L
Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGD 464
Query: 203 ELSPEPEGPLLRVCGRVPPPTLNTNASH-LLVVFVSDSSVEGFGFHAWYQAMAPG----- 256
+ +L + P L + +H + ++F +D S GF A Y+ + G
Sbjct: 465 GGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDP 524
Query: 257 --------RGSCAHD----EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGN 304
GS H +F C L+ N + + C C N
Sbjct: 525 GIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC---VFSCFFN 581
Query: 305 LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYET 364
T G +P+Y + Y + L C W I I L F++ +E Q FD++ + +
Sbjct: 582 FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFLVIKDG 637
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
+++ A +LG F G + P + SS H + F+TDH GF+ T+ F E P
Sbjct: 638 ATAEA-PVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECP 692
Score = 94.0 bits (232), Expect = 3e-19
Identities = 83/316 (26%), Positives = 123/316 (38%), Gaps = 34/316 (10%)
Query: 129 KGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA 188
K Q S P +C + P G SPNYP+ Y + HCVW I + I L
Sbjct: 563 KNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFND 622
Query: 189 LSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFH 247
+ +E L ++ E P+L P+ T++ H+ + F +D S GF+
Sbjct: 623 IDVEPQFDFLV--IKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFN 680
Query: 248 AWYQAM---------APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKF 298
+ P G D + I L D +GF GS+ C K
Sbjct: 681 ITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCD---EGFLG-TQGSETITCVLKE 736
Query: 299 SG-------------CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN 345
CGG+LT GT +P + Y L C W I G+ I++ F
Sbjct: 737 GSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDR 796
Query: 346 FSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSG 405
F + E +D +EV + + A L+G + G + P L+S+ + L +LF TD S
Sbjct: 797 F----KTEVNYDTLEVRDGRTYSA-PLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDI 851
Query: 406 GFSATYLAFNATENPC 421
GF Y + C
Sbjct: 852 GFQLRYETITLQSDHC 867
Score = 84.7 bits (208), Expect = 2e-16
Identities = 79/314 (25%), Positives = 128/314 (40%), Gaps = 46/314 (14%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
++ CGG L+ P G SP +P Y C W I+ + I++ + E +D
Sbjct: 749 EAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYD 804
Query: 201 RLELSPEP--EGPLLRVC-GRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA--- 254
LE+ PL+ V G P L + +++L ++F +D S GF Y+ +
Sbjct: 805 TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864
Query: 255 --------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG------ 300
P G ++F L+ CD +DG + C F
Sbjct: 865 DHCLDPGIPVNGQRHGNDFYVGALVTFS----CDSGYTLSDG-EPLECEPNFQWSRALPS 919
Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
CGG + G GT +P + YP+ L CTW I G + FH F LE+
Sbjct: 920 CEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLES----GH 975
Query: 357 DYVEVYETSSSGAFSL-LGRFCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYL 412
DY+ + E +G+F+ L + G+ P + + + V F +D +S GF+ T+
Sbjct: 976 DYLLITE---NGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFS 1032
Query: 413 AFNATENPCGPSEL 426
++ PC E+
Sbjct: 1033 EYDL--EPCEEPEV 1044
Score = 83.6 bits (205), Expect = 5e-16
Identities = 88/329 (26%), Positives = 133/329 (40%), Gaps = 63/329 (19%)
Query: 137 SPSPQST--CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH-----------AIQ 183
+P P T CGG G G SPNYP Y C++ + V D+ A+
Sbjct: 1610 NPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN 1669
Query: 184 LKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEG 243
+E S S L L S E +P T N +L+ F +
Sbjct: 1670 DVVEVHDGHSQHSRLLSSLSGSHTGES--------LPLATSN----QVLIKFSAKGLAPA 1717
Query: 244 FGFHAWYQAMA------------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDE 291
GFH YQA+ P G +F ++ +S G+A GS E
Sbjct: 1718 RGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNS---GYA--LQGSPE 1772
Query: 292 TNCS------AKFS--------GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGH 337
C A+++ CGGNLT +GT +P + + Y + L C W I VP G
Sbjct: 1773 IECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGA 1832
Query: 338 SIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFR 397
I++Q +F E +D +EV++ + ++LG F G P L S+ ++L + F
Sbjct: 1833 GIQIQVVSFVTEQN----WDSLEVFD-GADNTVTMLGSFSGTTVPALLNSTSNQLYLHFY 1887
Query: 398 TDHGISSGGFSATY--LAFNATENPCGPS 424
+D +S+ GF Y + ++ P PS
Sbjct: 1888 SDISVSAAGFHLEYKTVGLSSCPEPAVPS 1916
Score = 80.1 bits (196), Expect = 5e-15
Identities = 93/341 (27%), Positives = 133/341 (39%), Gaps = 53/341 (15%)
Query: 130 GQQESGVSPSPQ--STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE 187
G++ SP P+ + CG ++G +G SPN+P Y N C++ IQ IQLK
Sbjct: 1082 GRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKAR 1141
Query: 188 ALSI-ESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGF 246
A + E ++D S G + TLN+ +S L + F++D+ GF
Sbjct: 1142 AFELSEGDVLKVYDGNNNSARLLGVFSH--SEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199
Query: 247 HAWYQAM---------APGRGSCAHDE---------FRCD---------QLICLLPDSVC 279
+ + P G HDE F CD +L+CL
Sbjct: 1200 ELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCL------ 1253
Query: 280 DGFANCADGSDETNCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHS 338
G D T C A+ CGG + G + G +P Y Y H L C W I AG +
Sbjct: 1254 SGERRTWDRPLPT-CVAE---CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCT 1309
Query: 339 IELQFHNFSLEAQDECKFDYVEVYE-TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFR 397
I L F F E D + +++ SG LL G P L S+ + + + F
Sbjct: 1310 IGLHFLVFDTEE----VHDVLRIWDGPVESGV--LLKELSGPALPKDLHSTFNSVVLQFS 1363
Query: 398 TDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQW 438
TD S GF+ + AT C + Q G G W
Sbjct: 1364 TDFFTSKQGFAIQFSVSTATS--CNDPGIP-QNGSRSGDSW 1401
Score = 73.9 bits (180), Expect = 4e-13
Identities = 84/328 (25%), Positives = 125/328 (38%), Gaps = 76/328 (23%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG L G G SSP++P Y N C W I I L +E +D LE
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLE 257
Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM---------- 253
++ EG L G P + ++ + L + F SD + GF A YQ
Sbjct: 258 VTGT-EGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGV 316
Query: 254 -------------------------------APGRGSCAHDEFR--------CDQ----- 269
P RG +FR C++
Sbjct: 317 KLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQ 376
Query: 270 ----LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQL 325
+ C+ V D FA +D C A+ C +L G G ++P++ QY +
Sbjct: 377 GSKRITCM---KVSDMFAAWSD--HRPVCRARM--CDAHLRGPSGIITSPNFPIQYDNNA 429
Query: 326 LCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPP 383
C W I ++ I+L F F LE +D + V + G ++L G P
Sbjct: 430 HCVWIITALNPSKVIKLAFEEFDLER----GYDTLTVGDGGQDGDQKTVLYILTGTSVPD 485
Query: 384 HLVSSHHELAVLFRTDHGISSGGFSATY 411
+VS++H++ +LF+TD SS GF A+Y
Sbjct: 486 LIVSTNHQMWLLFQTDGSGSSLGFKASY 513
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/305 (25%), Positives = 121/305 (39%), Gaps = 44/305 (14%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P + CGG ++ G SP +P PY + CVW I V H ++L + L E
Sbjct: 2176 PKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGD- 2234
Query: 198 LFDRLELSPEPEGPLLRVCGR-VPPPTLNTNASHLLVVFVSDSSVEG---FGFHAWYQAM 253
F + P+ P L V R + T+ ++++ +L+ F D++ G F A+
Sbjct: 2235 -FITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTK 2293
Query: 254 AP-------GRGSCAHDEFRCDQLI---CLLPDSVCDGFANCADGSDETNCS----AKFS 299
P ++EF ++ CL GF G++ C +F
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCL------PGFT--LVGNEILTCKLGTYLQFE 2345
Query: 300 G--------CGGN--LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
G C N LT G + SY YP C+W + V ++I L F E
Sbjct: 2346 GPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSE 2405
Query: 350 AQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV-SSHHELAVLFRTDHGISSGGFS 408
Q +D E+++ SG LL G P +V SS + + + + +DH + GF
Sbjct: 2406 KQ----YDEFEIFD-GPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFK 2460
Query: 409 ATYLA 413
Y A
Sbjct: 2461 IRYSA 2465
Score = 70.1 bits (170), Expect = 5e-12
Identities = 82/307 (26%), Positives = 128/307 (41%), Gaps = 36/307 (11%)
Query: 132 QESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI 191
Q S PS ++ CGG + G G SP +PD YP N +C W I+ + + +
Sbjct: 912 QWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHL 971
Query: 192 ESVASCLFDRLELSPEPEGPLLRVCG-RVPPPT---LNTNASHLLVVFVSDSSVEGFGFH 247
ES L + + PL ++ G R+P P L N + V F+SD S+ GF+
Sbjct: 972 ESGHDYLL--ITENGSFTQPLRQLTGSRLPAPISAGLYGNFT-AQVRFISDFSMSYEGFN 1028
Query: 248 AWY---------QAMAPGRGSCAHDEFRCDQLICL--LPDSVCDGFA--NCADG------ 288
+ + P +F + P +G A C G
Sbjct: 1029 ITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWS 1088
Query: 289 SDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSL 348
S C A+ CG ++TG QGT +P++ Y + C + I G I+L+ F L
Sbjct: 1089 SPLPRCVAE---CGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFEL 1145
Query: 349 EAQDECKFDYVEVYETSSSGAFSLLGRFCGAE-PPPHLVSSHHELAVLFRTDHGISSGGF 407
+ D ++VY+ +++ A LLG F +E L S+ L + F TD +S GF
Sbjct: 1146 S-----EGDVLKVYDGNNNSA-RLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199
Query: 408 SATYLAF 414
+ +F
Sbjct: 1200 ELHFSSF 1206
Score = 52.8 bits (125), Expect = 9e-07
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGGN+T GT +P + Y C W I+VP GH + L N SL Q E D++
Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRL---NLSL-LQTEPSGDFIT 2237
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
+++ A LG F + + SS +++ + F D + G F+ + A+ T+ P
Sbjct: 2238 IWDGPQQTA-PRLGVFTRSMAKKTVQSSSNQVLLKFHRD-AATGGIFAIAFSAYPLTKCP 2295
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 123 bits (308), Expect = 5e-28
Identities = 90/283 (31%), Positives = 115/283 (40%), Gaps = 59/283 (20%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Q CG L+G G SP +P+ YP C W I I L I S A C D
Sbjct: 814 QVACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETD 872
Query: 201 RLEL-------SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM 253
+E+ SPE + + CG P + + + L V FV SS E GF A +
Sbjct: 873 YVEIGSSSILGSPENK----KYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF--- 925
Query: 254 APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFS 313
SA+ CG LT GT
Sbjct: 926 -----------------------------------------SAEDLACGEILTESTGTIQ 944
Query: 314 TPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
+P + YPH + CTWHI V H I L F F LE C DY+EVY+T S + L
Sbjct: 945 SPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSE---TSL 1001
Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
GR+CG PP L SS + L ++F TD ++ GF Y A +A
Sbjct: 1002 GRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISA 1044
Score = 117 bits (294), Expect = 2e-26
Identities = 83/263 (31%), Positives = 118/263 (44%), Gaps = 49/263 (18%)
Query: 153 GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIE-SVASCLFDRLELSPE--PE 209
G F+SPN+P+ YP N C++ I V T I + S+E ++ + D LE+ +
Sbjct: 1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEK 1116
Query: 210 GPLLRVC-GRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCD 268
PLL + G PPT+ ++++ L + F SD GF A++
Sbjct: 1117 SPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW------------------ 1158
Query: 269 QLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
DGS +GCGGNLT GTF +P+Y Y H C
Sbjct: 1159 ------------------DGSS--------TGCGGNLTTSSGTFISPNYPMPYYHSSECY 1192
Query: 329 WHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSS 388
W + G + EL+F +F LE C DY+ VY+ SS + LL + CG E PP + SS
Sbjct: 1193 WWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNS-HLLTQLCGDEKPPLIRSS 1251
Query: 389 HHELAVLFRTDHGISSGGFSATY 411
+ + RTD G GF A Y
Sbjct: 1252 GDSMFIKLRTDEGQQGRGFKAEY 1274
Score = 115 bits (288), Expect = 1e-25
Identities = 86/290 (29%), Positives = 127/290 (43%), Gaps = 56/290 (19%)
Query: 143 TCGGLLSGPRGFFSSPNYP-DPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDR 201
+CGG+ + G +SP Y YP + HC++ I V+ D I+LK + SC D
Sbjct: 3036 SCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDY 3095
Query: 202 LEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFH-AWYQAMAPGR 257
L + PLL + CG PP + ++ + +L+VF +DS G+ ++ Q + P +
Sbjct: 3096 LAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQ 3155
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
G CGG LTG TF++P
Sbjct: 3156 G------------------------------------------CGGYLTGSNNTFASPDS 3173
Query: 318 LQQ--YPHQLLCTWHISVPAGHSIELQFHNFSLEA---QDECKFDYVEVYETSSSGAFSL 372
Y L C W I P I L F+ F+LEA + C +DYV++Y+ S A +L
Sbjct: 3174 DSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENA-NL 3232
Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
G FCG+ P +SS + L V F +D + GF+ATY + PCG
Sbjct: 3233 AGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY---TIMDMPCG 3279
Score = 114 bits (285), Expect = 2e-25
Identities = 83/285 (29%), Positives = 130/285 (45%), Gaps = 56/285 (19%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CG +L+ G SP +P+ YP +C WHI V +H I L E +E +C D LE
Sbjct: 932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLE 991
Query: 204 L-SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAH 262
+ + E L R CG+ PP+L ++ + L++VFV+DS + GF Y+A++
Sbjct: 992 VYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAA------ 1045
Query: 263 DEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYP 322
+ C + T GTF++P++ YP
Sbjct: 1046 ------------------------------------TACLQDYTDDLGTFTSPNFPNNYP 1069
Query: 323 HQLLCTWHISVPAGHSIELQFHNFSL-EAQDECKFDYVEV----YETSSSGAFSLLGRFC 377
+ C + I+V G I + F NFSL EA D++E+ YE S LLG F
Sbjct: 1070 NNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKS-----PLLGIFY 1124
Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
G+ PP ++S ++L + F++D + GFSA + + + CG
Sbjct: 1125 GSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW---DGSSTGCG 1166
Score = 114 bits (285), Expect = 2e-25
Identities = 89/316 (28%), Positives = 128/316 (40%), Gaps = 69/316 (21%)
Query: 127 TPKGQQESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQL 184
T +GQQ G + TC +++ G S YP+PY N HC W I+ T + +
Sbjct: 1261 TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY 1320
Query: 185 KIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
A +E +C D LEL P + R CG PP +T +S L V+
Sbjct: 1321 TFLAFDLEHHINCSTDYLELYDGPR-QMGRYCGVDLPPPGSTTSSKLQVL---------- 1369
Query: 245 GFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS--GCG 302
LL D V G E ++ GCG
Sbjct: 1370 ----------------------------LLTDGV---------GRREKGFQMQWFVYGCG 1392
Query: 303 GNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVY 362
G L+G G+FS+P + +YP C W+I G SI+L H+F +E C FD +E+Y
Sbjct: 1393 GELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIY 1452
Query: 363 --ETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
S + L E P + S+ +ELA+ F+TD I+ GF+A++ A
Sbjct: 1453 GGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAV------ 1506
Query: 421 CGPSELSCQAGGCKGV 436
GGC G+
Sbjct: 1507 ---------TGGCGGI 1513
Score = 113 bits (283), Expect = 4e-25
Identities = 91/315 (28%), Positives = 131/315 (41%), Gaps = 61/315 (19%)
Query: 105 LPAGGLTTTTTTPTITTSQAAGT-PKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDP 163
LP G TT++ + + G KG Q CGG LSG G FSSP +P+
Sbjct: 1355 LPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYG----CGGELSGATGSFSSPGFPNR 1410
Query: 164 YPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPEPEGP-LLRVC-GRV 219
YPPN C+W+I+ +IQL I +E + C FD LE+ P+ P + ++C R
Sbjct: 1411 YPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRS 1470
Query: 220 P--PPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDS 277
P P +++ + L + F +D S+ G GF+A +QA+
Sbjct: 1471 PENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT----------------------- 1507
Query: 278 VCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGH 337
GCGG G +P+Y Y C+W I V H
Sbjct: 1508 ---------------------GGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNH 1546
Query: 338 SIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPH-LVSSHHELAVLF 396
+ L F +F LE QD C Y S S L R CG E + +VSS + L + F
Sbjct: 1547 RVLLNFTDFDLEPQDSCIMAY-----DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRF 1601
Query: 397 RTDHGISSGGFSATY 411
++ + GF A +
Sbjct: 1602 QSGPSRQNRGFRAQF 1616
Score = 113 bits (283), Expect = 4e-25
Identities = 86/298 (28%), Positives = 126/298 (42%), Gaps = 52/298 (17%)
Query: 131 QQESGVSPSPQSTCGG-LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATD-HAIQLKIEA 188
+Q G + CGG +L+ SSP +P YP N +C W IQ + I L
Sbjct: 1607 RQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTH 1666
Query: 189 LSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
+E +C D +E+ + PL R CG P + + +S L + FVSDSS+ G
Sbjct: 1667 FELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGG 1726
Query: 246 FHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNL 305
FH T +A S CGG
Sbjct: 1727 FH--------------------------------------------TTVTASVSACGGTF 1742
Query: 306 TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETS 365
+G F++P Y YP + C W+I G+ ++L F +F LE +C D+VE+ E +
Sbjct: 1743 YMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGN 1802
Query: 366 SSGAFSLLGRFCGAEPPPHLVS-SHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
++G L+GR+CG P + S H L V F +D S GF AT++ +N G
Sbjct: 1803 ATG--HLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVG 1858
Score = 109 bits (272), Expect = 8e-24
Identities = 75/284 (26%), Positives = 120/284 (42%), Gaps = 49/284 (17%)
Query: 144 CGGLLSGPRGFFSSPNYPD-PYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
CGG + G G S +P PY N C WH+Q + H + + E ++++ + C D +
Sbjct: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395
Query: 203 EL-SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
E+ G +L R CG P +++T+++ +V FV+D SV GF +++
Sbjct: 2396 EIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFES-------- 2447
Query: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
CGG+L G GTF++P+Y
Sbjct: 2448 ------------------------------------SMEECGGDLQGSIGTFTSPNYPNP 2471
Query: 321 YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
PH +C W I+ P G I L F+N L C ++V V+ S + L
Sbjct: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
Query: 381 PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPS 424
+ SS + + V+F TD GGF+A+Y ++ + CG S
Sbjct: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYT--SSEDAVCGGS 2573
Score = 107 bits (266), Expect = 4e-23
Identities = 82/292 (28%), Positives = 120/292 (41%), Gaps = 55/292 (18%)
Query: 128 PKGQQESGVSPSPQSTCGGLLSG-PRGFFSSPNYPDP--YPPNTHCVWHIQVAT--DHAI 182
P G + + S + CGG L P G F+SP Y Y N +C W + + +I
Sbjct: 2554 PYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSI 2613
Query: 183 QLKIEALSIESVASCLFDRLELSP-EPEGPLL-RVCGRVPPPT-LNTNASHLLVVFVSDS 239
+ E +ES C FD LE + +GPL+ R+CG P L S + + FV++
Sbjct: 2614 SIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNE 2673
Query: 240 SVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
VE GFHA Y F+
Sbjct: 2674 RVEHIGFHAKYS----------------------------------------------FT 2687
Query: 300 GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYV 359
CGG G G ++P+Y Y C+ + P GH+I L F +F +E C +D V
Sbjct: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747
Query: 360 EVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
V S ++G++CG P + S ++L V F +DH + GGF AT+
Sbjct: 2748 TV-RNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATW 2798
Score = 106 bits (265), Expect = 5e-23
Identities = 73/274 (26%), Positives = 104/274 (37%), Gaps = 50/274 (18%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Q CGG+L+GP G SP YP YPP CVW + + D + LS+E C D
Sbjct: 587 QPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKD 646
Query: 201 RLELSPEP--EGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
LE+ P + PLL + C P L T + F SDS + GFH Y
Sbjct: 647 YLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT----- 701
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
S CGGN T +G P
Sbjct: 702 -------------------------------------SPSDLRCGGNYTDPEGELFLPEL 724
Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
+ H C + + P G I++ F + L+ Q + +Y+EV + +LLG+ C
Sbjct: 725 SGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGE-----TLLGKVC 779
Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
G H+ S + + + F+ D + F A Y
Sbjct: 780 GNGTISHIKSITNSVWIRFKIDASVEKASFRAVY 813
Score = 104 bits (260), Expect = 2e-22
Identities = 83/283 (29%), Positives = 115/283 (40%), Gaps = 57/283 (20%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+ P G SPNYP PY NT C W I+V +H + L +E SC+
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDG 1569
Query: 204 LSPEPEGPLLRVCGR--VPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCA 261
LS L R CGR + P +++ S L + F S S + GF A ++
Sbjct: 1570 LS-STMSRLARTCGREQLANPIVSSGNS-LFLRFQSGPSRQNRGFRAQFR---------- 1617
Query: 262 HDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGN-LTGLQGTFSTPSYLQQ 320
CGG+ LT T S+P +
Sbjct: 1618 -------------------------------------QACGGHILTSSFDTVSSPRFPAN 1640
Query: 321 YPHQLLCTWHISV-PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
YP+ C+W I P + I L F +F LE C D+VE+ + A L GR+CG
Sbjct: 1641 YPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDA-PLRGRYCGT 1699
Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
+ P + S L + F +D IS+GGF T A+ + CG
Sbjct: 1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTT---VTASVSACG 1739
Score = 104 bits (260), Expect = 2e-22
Identities = 83/329 (25%), Positives = 136/329 (41%), Gaps = 59/329 (17%)
Query: 105 LPAGGLTTTTTTPTITTSQAAGTPKGQQES---GVSPSPQSTCGGLLSGPRGFFSSPNYP 161
L A G P IT S QE+ G S S S CG +GP G+ SPNYP
Sbjct: 2878 LLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYP 2937
Query: 162 DPYPPNTHCVWHIQVATDHAIQLKIEALSIES----VASCLFDRLELS---PEPEGPLLR 214
Y N +C + I+ + L + +E+ SC+ D + + P
Sbjct: 2938 KQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFAT 2997
Query: 215 VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLL 274
VCG P L T A +L+ F S+ + FGF Y+ ++
Sbjct: 2998 VCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKFSYRIIS-------------------- 3036
Query: 275 PDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY-LQQYPHQLLCTWHISV 333
CGG G ++P+Y YP+ + C + I+V
Sbjct: 3037 --------------------------CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITV 3070
Query: 334 PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELA 393
IEL+F +F + C DY+ +Y+ +++ LLG+FCG++ PP++ SS++ +
Sbjct: 3071 SDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSD-PLLGKFCGSKRPPNVKSSNNSML 3129
Query: 394 VLFRTDHGISSGGFSATYLAFNATENPCG 422
++F+TD ++ G+ ++ + CG
Sbjct: 3130 LVFKTDSFQTAKGWKMSFRQTLGPQQGCG 3158
Score = 103 bits (257), Expect = 4e-22
Identities = 74/288 (25%), Positives = 124/288 (43%), Gaps = 60/288 (20%)
Query: 144 CGGLL----SGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE-ALSIESVASCL 198
CGG + + G+ +SPN+P YPP+ C+W + + IQL+ E IE +C
Sbjct: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCT 2276
Query: 199 FDRLELSP--EPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAP 255
+ LEL + + P+L + CG P + ++ + + F SD+S GF A Y
Sbjct: 2277 SNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS---- 2332
Query: 256 GRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTP 315
+ CGG + G G +
Sbjct: 2333 ------------------------------------------IAQCGGRVPGQSGVVESI 2350
Query: 316 SY-LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG 374
+ Y L C WH+ +GH + + F +F+L+ C+ D+VE+++ +SG ++LG
Sbjct: 2351 GHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSG--NILG 2408
Query: 375 RFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
R+CG P + +S + V F TD +++ GF L F ++ CG
Sbjct: 2409 RYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFR---LRFESSMEECG 2453
Score = 102 bits (255), Expect = 7e-22
Identities = 86/329 (26%), Positives = 130/329 (39%), Gaps = 60/329 (18%)
Query: 102 HSPLPAGGLTTTTTTP-TITTSQAAGTPKGQQESGVSP--------SPQSTCGGLLSGPR 152
H P G T P IT+ +A T + +S +S + S CGG
Sbjct: 1687 HEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYMAE 1746
Query: 153 GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL-SPEPEGP 211
G F+SP YPD YPPN CVW+I + + +QL + +E C D +E+ G
Sbjct: 1747 GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGH 1806
Query: 212 LL-RVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ 269
L+ R CG P ++ H L V F+SD S G GF A + +
Sbjct: 1807 LVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKI---------------- 1850
Query: 270 LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
F N N+ G G ++P + + YPH W
Sbjct: 1851 ------------FGN------------------DNIVGTHGKVASPFWPENYPHNSNYQW 1880
Query: 330 HISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSH 389
++V A H + + +E C +D + +Y+ S A L+G +CG + S+
Sbjct: 1881 TVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA-RLIGAYCGTQ-TESFSSTG 1938
Query: 390 HELAVLFRTDHGISSGGFSATYLAFNATE 418
+ L F +D IS GF + A +A +
Sbjct: 1939 NSLTFHFYSDSSISGKGFLLEWFAVDAPD 1967
Score = 99.4 bits (246), Expect = 8e-21
Identities = 80/295 (27%), Positives = 119/295 (40%), Gaps = 62/295 (21%)
Query: 134 SGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA--LSI 191
+G + S +CGG L RG +SP YP+ YP N +C WH+ V + I + E
Sbjct: 2082 AGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIP 2141
Query: 192 ESVASC-------LFDRLELSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSV 241
+SC L + ++ P GP CG TL T+ + + V F+SD S
Sbjct: 2142 NGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSN 2201
Query: 242 EGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGC 301
EG GF Y+ AK C
Sbjct: 2202 EGQGFKIKYE--------------------------------------------AKSLAC 2217
Query: 302 GGNL----TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN-FSLEAQDECKF 356
GGN+ G ++P++ YP C W ++ P I+LQF + F +E C
Sbjct: 2218 GGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTS 2277
Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
+Y+E+ + S A +L +FCG P SS + + FR+D+ + GF A Y
Sbjct: 2278 NYLELRDGVDSDA-PILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
Score = 98.6 bits (244), Expect = 1e-20
Identities = 70/286 (24%), Positives = 120/286 (41%), Gaps = 51/286 (17%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG+ G G +SPNYP+ Y THC ++ H I L IE +C +D +
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
Query: 204 L--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ PE P++ + CG P T+ + ++ L+V F SD S++G GF+A + G G
Sbjct: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGI 2808
Query: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
H + GT +P + Q
Sbjct: 2809 FHSD--------------------------------------------NGTIRSPHWPQN 2824
Query: 321 YPHQLLCTWHISVPAGHSIELQF-HNFSLEAQD-ECKFDYVEVYETSSSGAFSLLGRFCG 378
+P C+W +E+ F +NF + + D +C+ +V+V+ + +LL CG
Sbjct: 2825 FPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCG 2884
Query: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPS 424
P +++ + +F++ + GFSA++++ N GPS
Sbjct: 2885 NVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVS-RCGSNFTGPS 2928
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/293 (26%), Positives = 114/293 (38%), Gaps = 62/293 (21%)
Query: 135 GVSPS-PQSTCGGLLSGPRG--FFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI 191
GV P+ CGG L F SP +PD Y C W IQ A D ++L I +L I
Sbjct: 1968 GVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQ-APDSTVELNILSLDI 2026
Query: 192 ESVASCLFDRLELSPEPEG---PLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHA 248
ES +C +D L + L +CGR P + + ++ + F SDSSV GF+A
Sbjct: 2027 ESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNA 2086
Query: 249 WYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGL 308
+ CGG L
Sbjct: 2087 SFH-----------------------------------------------KSCGGYLHAD 2099
Query: 309 QGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN-FSLEAQDEC--KFDYVEVYE-- 363
+G ++P Y + YP L C+WH+ V +G +I + F F + D + DY+ +
Sbjct: 2100 RGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGP 2159
Query: 364 ---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
+ G G FCG+ L +S +++ V F +DH GF Y A
Sbjct: 2160 DICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEA 2212
Score = 90.1 bits (222), Expect = 5e-18
Identities = 72/292 (24%), Positives = 113/292 (38%), Gaps = 60/292 (20%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG L+ G F SPNYP PY ++ C W ++ + A +L+ + +E +C D L
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
Query: 204 LSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
+ P L ++CG PP + ++ + + +D +G GF A Y+
Sbjct: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQ-------- 1276
Query: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
C+ ++ + N T G + Y
Sbjct: 1277 -----TCENVVIV------------------------------NQT--YGILESIGYPNP 1299
Query: 321 YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
Y C W I G+++ F F LE C DY+E+Y+ +GR+CG +
Sbjct: 1300 YSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQ-----MGRYCGVD 1354
Query: 381 PPPHLVSSHHELAVLFRTDH-GISSGGFSATYLAFNATENPCGPSELSCQAG 431
PP ++ +L VL TD G GF + + CG ELS G
Sbjct: 1355 LPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYG-----CG-GELSGATG 1400
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/286 (26%), Positives = 119/286 (41%), Gaps = 61/286 (21%)
Query: 139 SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC- 197
S CGG L G G F+SPNYP+P P C W I I L L + + SC
Sbjct: 2447 SSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCN 2506
Query: 198 -----LFDRLELSPEPEGPLLRVCGRVPPPT-LNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
+F+ + S P+ L ++C V + ++ + + V+F +D S GF A Y
Sbjct: 2507 NEHVIVFNGIR-SNSPQ--LEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY- 2562
Query: 252 AMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGL-QG 310
S++ + CGG+L +G
Sbjct: 2563 ------------------------------------------TSSEDAVCGGSLPNTPEG 2580
Query: 311 TFSTPSY--LQQYPHQLLCTWHISVP--AGHSIELQFHNFSLEAQDECKFDYVEVYETSS 366
F++P Y ++ Y L C W +S P SI + F +F LE+ +C+FD +E +
Sbjct: 2581 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA 2640
Query: 367 SGAFSLLGRFCG-AEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
G L+ R CG ++P LV + ++ + F T+ + GF A Y
Sbjct: 2641 DG--PLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
Score = 84.3 bits (207), Expect = 3e-16
Identities = 63/263 (23%), Positives = 107/263 (40%), Gaps = 49/263 (18%)
Query: 153 GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPEPEG 210
G SP +PD Y + C + +H I L +L IE+ C D LE+
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
Query: 211 PLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ 269
PLL + CG + P + + + L + F SDS G+
Sbjct: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY----------------------- 3500
Query: 270 LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
E ++ SGCGG L G +G+F++P Y YP+ C W
Sbjct: 3501 ---------------------EIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEW 3539
Query: 330 HISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPP-PHLVSS 388
+ PAG + + F+ S++ +C +Y+ +Y+ ++ + S G +CG + V+S
Sbjct: 3540 VLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPS-SGPYCGGDTSIAPFVAS 3598
Query: 389 HHELAVLFRTDHGISSGGFSATY 411
+++ + F D+ F T+
Sbjct: 3599 SNQVFIKFHADYARRPSAFRLTW 3621
Score = 83.6 bits (205), Expect = 5e-16
Identities = 60/265 (22%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 150 GPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPE 207
G G +SP +P+ YP N++ W + V H + +I + IE + +C +D+L + P
Sbjct: 1858 GTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917
Query: 208 PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHA-WYQAMAPGRGSCAHDEFR 266
L+ + ++ + L F SDSS+ G GF W+ AP
Sbjct: 1918 IHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAP----------- 1966
Query: 267 CDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
D ++ + C GF D +P + Y +++
Sbjct: 1967 -DGVLPTIAPGACGGFLRTGDAPV--------------------FLFSPGWPDSYSNRVD 2005
Query: 327 CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV 386
CTW I P ++EL + +E+ C +D + + + ++ A L CG E P +
Sbjct: 2006 CTWLIQAPDS-TVELNILSLDIESHRTCAYDSLVIRDGDNNLA-QQLAVLCGREIPGPIR 2063
Query: 387 SSHHELAVLFRTDHGISSGGFSATY 411
S+ + + F +D ++ GF+A++
Sbjct: 2064 STGEYMFIRFTSDSSVTRAGFNASF 2088
Score = 80.9 bits (198), Expect = 3e-15
Identities = 75/292 (25%), Positives = 108/292 (36%), Gaps = 56/292 (19%)
Query: 140 PQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLF 199
PQ CG LSG G FS + Y + +C W I+ +++ +ES+ +C
Sbjct: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529
Query: 200 DRLELSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
+ L++ L R CG P H L+ SS FH + + + G
Sbjct: 530 EFLQVYDGDSSSAFQLGRFCGSSLP--------HELL-----SSDNALYFHLYSEHLRNG 576
Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
RG E + + CGG LTG G+ +P
Sbjct: 577 RGFTVRWETQQPE-------------------------------CGGILTGPYGSIKSPG 605
Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRF 376
Y YP C W + + F SLE D+C DY+E+ + LLG+F
Sbjct: 606 YPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD-GPLYQDPLLGKF 664
Query: 377 CGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSC 428
C P L ++ + F +D IS GF TYL PS+L C
Sbjct: 665 CTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT--------SPSDLRC 708
Score = 79.7 bits (195), Expect = 7e-15
Identities = 51/156 (32%), Positives = 76/156 (48%), Gaps = 17/156 (10%)
Query: 279 CDGFANCADGSDETNCSAK--FSG---------CGGNLTGLQGTFSTPSYLQQYPHQLLC 327
C C DG D +C ++G CG +L+G+ G+FS S Y H + C
Sbjct: 441 CLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500
Query: 328 TWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVS 387
W I G + + F F LE+ D C ++++VY+ SS AF LGRFCG+ P L+S
Sbjct: 501 FWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQ-LGRFCGSSLPHELLS 559
Query: 388 SHHELAVLFRTDHGISSGGFSATYLAFNATENP-CG 422
S + L ++H + GF+ + T+ P CG
Sbjct: 560 SDNALYFHLYSEHLRNGRGFTVRW----ETQQPECG 591
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 56/285 (19%)
Query: 144 CGGLLSG---PRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
CGG + P+ SSPN DP P + C W I +++ + AL + S C +
Sbjct: 3278 CGGTYNATWTPQNI-SSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTS-QDCTQN 3335
Query: 201 RLELSPEPEG---PLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
L+L P+G + CGR NAS + V + S S+
Sbjct: 3336 YLQLQDSPQGHGNSRFQFCGR--------NASAVPVFYSSMSTA---------------- 3371
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
+ + V + + + +C+ + GNL +P +
Sbjct: 3372 -------------MVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLR-------SPGW 3411
Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
Y + CT ++ P H+I L FH+ +E EC+ D++EV S+S + LLG++C
Sbjct: 3412 PDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS-PLLGKYC 3470
Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
G P + S ++EL + F++D S G+ + + ++ + CG
Sbjct: 3471 GTLLPNPVFSQNNELYLRFKSDSVTSDRGYE---IIWTSSPSGCG 3512
Score = 73.2 bits (178), Expect = 6e-13
Identities = 66/284 (23%), Positives = 106/284 (37%), Gaps = 63/284 (22%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGG + P G P P+ CV+ ++ IQ+ + ++ + + +E
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
+ + E L +VCG + + + + + F D+SVE F A YQ
Sbjct: 768 VR-DGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV----------- 815
Query: 264 EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPH 323
CG LTG +G +P + YP
Sbjct: 816 ------------------------------------ACGDELTG-EGVIRSPFFPNVYPG 838
Query: 324 QLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG-----RFCG 378
+ C W I P I L F F + + C+ DYVE+ G+ S+LG ++CG
Sbjct: 839 ERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI------GSSSILGSPENKKYCG 892
Query: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
+ P + S ++ L V F + GF A F+A + CG
Sbjct: 893 TDIPSFITSVYNFLYVTFVKSSSTENHGFMA---KFSAEDLACG 933
Score = 67.0 bits (162), Expect = 4e-11
Identities = 69/282 (24%), Positives = 107/282 (37%), Gaps = 54/282 (19%)
Query: 140 PQSTCGGLLSGPRGFFSSPNYPDP--YPPNTHCVWHIQVATDHAIQLKIEALSIESVAS- 196
PQ CGG L+G F+SP+ Y N +CVW I + I L ++E+ ++
Sbjct: 3153 PQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTR 3212
Query: 197 --CLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
CL+D ++L E CG P ++ + L V F+SD ++E GF+A Y
Sbjct: 3213 QRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYT 3272
Query: 252 AMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGT 311
M D C G N T
Sbjct: 3273 IM----------------------DMPCGGTYNA--------------------TWTPQN 3290
Query: 312 FSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFS 371
S+P+ +CTW I P +++ L +QD C +Y+++ + S G +
Sbjct: 3291 ISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQL-QDSPQGHGN 3348
Query: 372 LLGRFCG--AEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
+FCG A P SS V+F++ + S TY
Sbjct: 3349 SRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTY 3390
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/118 (31%), Positives = 48/118 (40%), Gaps = 19/118 (16%)
Query: 139 SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC- 197
S S CGG L G RG F+SP YP YP NT+C W + + + +SI+ C
Sbjct: 3506 SSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCV 3565
Query: 198 -----LFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
L+D S GP CG + FV+ S+ FHA Y
Sbjct: 3566 QNYLTLYDGPNASSPSSGP---YCG----------GDTSIAPFVASSNQVFIKFHADY 3610
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 122 bits (306), Expect = 9e-28
Identities = 92/312 (29%), Positives = 138/312 (44%), Gaps = 42/312 (13%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
PS C G + RG SP YP+PY N +C+W I V IQ+++ + + E
Sbjct: 1797 PSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN--- 1853
Query: 198 LFDRLELSPEPEGPLLRV---CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA 254
+D LE+ + R+ G P LN+ ++ L + F SD SV GFH Y+ +
Sbjct: 1854 -WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVG 1912
Query: 255 ---------PGRGSCAHDEFRCDQLICLL--PDSVCDGFAN--CADGS------DETNCS 295
P D + + ++ P G ++ C G+ C
Sbjct: 1913 LAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI 1972
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A CGG L+ L G +P + YP+ L CTW IS+P G+ +QF NFS EA
Sbjct: 1973 AT---CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEA----N 2025
Query: 356 FDYVEV----YETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
D++E+ Y TS ++G+F G + P L+S+ HE + F +DH + GF Y
Sbjct: 2026 HDFLEIQNGPYHTS-----PMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY 2080
Query: 412 LAFNATENPCGP 423
A+ P P
Sbjct: 2081 QAYELQNCPDPP 2092
Score = 110 bits (275), Expect = 4e-24
Identities = 86/299 (28%), Positives = 127/299 (42%), Gaps = 35/299 (11%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVA-TDHAIQLKIEALSIESVASCLFDR 201
TCG L GP G +SPNYP Y N HCVW I D I+L E +E +D
Sbjct: 411 TCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDT 466
Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
L + + L + G P + + ++ + + SD S+ GF A YQ + G
Sbjct: 467 LTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG 526
Query: 257 --------------RGSCAHDE---FRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
S H + F C L+ + V N ++ +C
Sbjct: 527 GCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC---VF 583
Query: 300 GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYV 359
C N T G +P+Y ++Y + + C W I G I L F++F +E Q FD++
Sbjct: 584 SCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQ----FDFL 639
Query: 360 EVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
V + S ++LG F G E P L SS H + + F++DH + GF+ TY F E
Sbjct: 640 AVKDDGISD-ITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNE 697
Score = 98.2 bits (243), Expect = 2e-20
Identities = 89/326 (27%), Positives = 126/326 (38%), Gaps = 54/326 (16%)
Query: 129 KGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA 188
+ Q SG PS +C + G SPNYP+ Y N +CVW I I L
Sbjct: 570 QNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFND 629
Query: 189 LSIESVASCLFDRLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
+E FD L + + + G P L ++ + + F SD S G G
Sbjct: 630 FDVEP----QFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRG 685
Query: 246 FHAWYQAMAPGRGSCAHD--------------------EFRCD----------QLICLLP 275
F+ Y G+ C HD F CD + C+L
Sbjct: 686 FNITYTTF--GQNEC-HDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQ 742
Query: 276 DSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPA 335
D N S C A CGG+LT G P + Y L C W I
Sbjct: 743 D------GNVVWSSTVPRCEAP---CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKP 793
Query: 336 GHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVL 395
GHSI++ F F Q E +D +EV + +S + L+G + G + P L+S+ + + +L
Sbjct: 794 GHSIKITFDRF----QTEVNYDTLEVRDGPASSS-PLIGEYHGTQAPQFLISTGNFMYLL 848
Query: 396 FRTDHGISSGGFSATYLAFNATENPC 421
F TD+ SS GF Y + + C
Sbjct: 849 FTTDNSRSSIGFLIHYESVTLESDSC 874
Score = 94.4 bits (233), Expect = 3e-19
Identities = 80/298 (26%), Positives = 121/298 (40%), Gaps = 36/298 (12%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
CGGL+ GP G SP +P YP +C W I + IQL ++E FD L
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 204 L---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA------ 254
+ P+ +R+ G P ++ + S L + F +D +V GF A Y+ +
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Query: 255 PG---RGSCAHDEFRCDQLI--CLLPDSVCDGFA---------NCADGSDETNCSAKFSG 300
PG +G F I LP + +G A N A
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207
Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
CGG L G + S+P + +Y + CTW I G +I L F +F LE +D++E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GYDFLE 263
Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
+ T + + G P ++SS + L + F +D GF+A + A E
Sbjct: 264 ISGTEAPSIW-----LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316
Score = 93.6 bits (231), Expect = 4e-19
Identities = 84/317 (26%), Positives = 131/317 (41%), Gaps = 48/317 (15%)
Query: 134 SGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIES 193
S P ++ CGG L+ G P +P Y + HC W I+ H+I++ + E
Sbjct: 749 SSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE- 807
Query: 194 VASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
+D LE+ P PL+ G P L + + + ++F +D+S GF Y
Sbjct: 808 ---VNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHY 864
Query: 251 QAMAPGRGSCAHD-------------------EFRCDQLICLLPDS--VCDGFANCADGS 289
+++ SC F CD L D VC+ N
Sbjct: 865 ESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCE--RNHQWNH 922
Query: 290 DETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
+C A CGG + G GT +P + YP+ L CTW I V G +++ FH F LE
Sbjct: 923 ALPSCDAL---CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE 979
Query: 350 AQDECKFDYVEVYETSSSGAFS-LLGRFCGAEPPPHLVSS----HHELAVLFRTDHGISS 404
+ DY+ + E G+FS + R G+ PH + + + + F +D IS
Sbjct: 980 S----SHDYLLITE---DGSFSEPVARLTGS-VLPHTIKAGLFGNFTAQLRFISDFSISY 1031
Query: 405 GGFSATYLAFNATENPC 421
GF+ T+ ++ PC
Sbjct: 1032 EGFNITFSEYDL--EPC 1046
Score = 92.0 bits (227), Expect = 1e-18
Identities = 82/307 (26%), Positives = 130/307 (42%), Gaps = 38/307 (12%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P+ + CGG L+GP G SPNYP PYPP C W ++V D I L ++ ++E S
Sbjct: 1446 PTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME--PSY 1503
Query: 198 LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ----- 251
F + + PL+ G P + ++ + L + F SD+SV GF ++
Sbjct: 1504 DFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPRE 1563
Query: 252 -AMAPG---RGSCAHDEFRCDQLICLLPDS----VCDGFANCADGSDE--------TNCS 295
PG G+ +F+ I DS + C G+D +C+
Sbjct: 1564 ACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN 1623
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A CGG TG +G +P+Y Y +C + I+VP + QF F
Sbjct: 1624 AP---CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN---- 1676
Query: 356 FDYVEVYETSSSGA---FSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYL 412
D E+++ + + A SL G G P +++ +++ + F G S+ GF Y
Sbjct: 1677 -DLAELFDGTHAQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGFHFVYQ 1732
Query: 413 AFNATEN 419
A T +
Sbjct: 1733 AVPRTSD 1739
Score = 87.8 bits (216), Expect = 2e-17
Identities = 83/292 (28%), Positives = 122/292 (41%), Gaps = 34/292 (11%)
Query: 138 PSPQ--STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVA 195
PSP +TCGG LS G SP +P YP N C W I + + I+ L+ + A
Sbjct: 1967 PSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAH--IQFLNFSTEA 2024
Query: 196 SCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM- 253
+ F ++ P P++ + G P L + L+ F SD S GF YQA
Sbjct: 2025 NHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYE 2084
Query: 254 ---APG-----RGSCAHDEFRCDQLICL--LPDSVCDG--FANCADGSDET------NCS 295
P G + ++ Q + P + G C G + C
Sbjct: 2085 LQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144
Query: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
A CG N+T GT +P + +YP C W I+VP GH + + NF+L Q E
Sbjct: 2145 AP---CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGV---YINFTL-LQTEAV 2197
Query: 356 FDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGF 407
DY+ V++ + LG F G SS +++ + F +D S+GGF
Sbjct: 2198 NDYIAVWDGPDQNS-PQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGF 2246
Score = 86.7 bits (213), Expect = 5e-17
Identities = 88/327 (26%), Positives = 130/327 (39%), Gaps = 38/327 (11%)
Query: 124 AAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAI- 182
A G P Q V PS + CGG +G G SPNYP Y C++ I V + +
Sbjct: 1609 ADGKPSWDQ---VLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVF 1665
Query: 183 -QLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSV 241
Q ++ +A LFD L P +N +L+ F + S
Sbjct: 1666 GQFAYFQTALNDLAE-LFDGTHAQARLLSSLSGSHSGETLPLATSN--QILLRFSAKSGA 1722
Query: 242 EGFGFHAWYQAMA------------PGRGSCAHDEFRCDQLI-------CLLPDSV---C 279
GFH YQA+ P G EF ++ LL S C
Sbjct: 1723 SARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHC 1782
Query: 280 DGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSI 339
N ++T S C GN T +GT +P Y + Y + L C W I V G I
Sbjct: 1783 QSVPNALAQWNDTIPSCVVP-CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGI 1841
Query: 340 ELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTD 399
++Q +F+ E +D +E+++ A LG F G P L S+ ++L + F++D
Sbjct: 1842 QIQVISFATEQ----NWDSLEIHDGGDVTA-PRLGSFSGTTVPALLNSTSNQLYLHFQSD 1896
Query: 400 HGISSGGFSATY--LAFNATENPCGPS 424
+++ GF Y + A + P PS
Sbjct: 1897 ISVAAAGFHLEYKTVGLAACQEPALPS 1923
Score = 75.1 bits (183), Expect = 2e-13
Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 39/332 (11%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
P + CG + G G SPN+P Y N C++ I+ I L+ + + E
Sbjct: 1099 PRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTL 1158
Query: 197 CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM--- 253
++D + S P G + + LN+ ++HL + F ++ S GF Y +
Sbjct: 1159 KVYDGKDSSSRPLGTFTK--NELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLV 1216
Query: 254 ------APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC------------S 295
P G DE + L S G+A GS+ C
Sbjct: 1217 KCEDPGIPNYGYRIRDEGHFTDTVVLY--SCNPGYA--MHGSNTLTCLSGDRRVWDKPLP 1272
Query: 296 AKFSGCGGNL-TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
+ + CGG + G +P Y Y + L CTW I G +I L F F E
Sbjct: 1273 SCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVF----DTEM 1328
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY-LA 413
D ++V++ LL + G+ P + S+ + L + F +D IS GFS + +
Sbjct: 1329 AHDILKVWDGPVDSDI-LLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTS 1387
Query: 414 FNATENPCGPSELSCQAGGCK----GVQWMCD 441
AT N G + + G + V + CD
Sbjct: 1388 IAATCNDPGMPQNGTRYGDSREAGDTVTFQCD 1419
Score = 74.3 bits (181), Expect = 3e-13
Identities = 80/325 (24%), Positives = 120/325 (36%), Gaps = 63/325 (19%)
Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
+ CGG L G SSP++P Y N C W I I L +E +D
Sbjct: 205 EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YD 260
Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA-------- 252
LE+S E P + + G P + ++ + L + F SDS+ GF+A +Q
Sbjct: 261 FLEIS-GTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKS 319
Query: 253 ----MAPGRGSCAHDEFRCDQLICLLPDSVCD------------GFA--------NCAD- 287
M P + + + L+ D D F+ +C D
Sbjct: 320 RGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDN 379
Query: 288 ----GSDETNCS---------------AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
GS C + CG NL G G ++P+Y QY C
Sbjct: 380 YVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439
Query: 329 WHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPPHLV 386
W I + I+L F F LE +D + V + G S+L G+ P +V
Sbjct: 440 WVITTTDPDKVIKLAFEEFELER----GYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 387 SSHHELAVLFRTDHGISSGGFSATY 411
S +++ + ++D I S GF A Y
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGFKAVY 520
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/299 (25%), Positives = 116/299 (38%), Gaps = 32/299 (10%)
Query: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
P + CG ++ G SP +PD YP C+W I V H + + L E+V
Sbjct: 2141 PRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDY 2200
Query: 198 LFDRLELSPEPEGPLLRV-CGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
+ + P+ P L V G T ++ + +L+ F SD S GF FHA+
Sbjct: 2201 I--AVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKK 2258
Query: 251 ----QAMAPGRGSCAHDEF--------RCDQLICLLPDSV--CDGFANCADGSDETNCSA 296
A+ D+F +C L+ + C + C A
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318
Query: 297 KFSGCGGN--LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
+ C N TG G +P Y Y + C+W I V ++I + F Q E
Sbjct: 2319 Q---CPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF----QSEK 2371
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
+FD +EV++ SS + L+ + S ++L + + TDH S GF Y A
Sbjct: 2372 QFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430
Score = 72.8 bits (177), Expect = 8e-13
Identities = 77/330 (23%), Positives = 124/330 (37%), Gaps = 52/330 (15%)
Query: 118 TITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVA 177
T++ + + Q + PS + CGG + G G SP +PD YP + +C W I+V+
Sbjct: 905 TLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVS 964
Query: 178 TDHAIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVV--- 234
+Q+ +ES L + P+ R+ G V P T+
Sbjct: 965 HGKGVQMIFHTFHLESSHDYLL--ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLR 1022
Query: 235 FVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ---------------------LICL 273
F+SD S+ GF+ + +D CD C
Sbjct: 1023 FISDFSISYEGFNITFS---------EYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCF 1073
Query: 274 L-------PDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
L C G + C A+ CG ++ G +GT +P++ Y +
Sbjct: 1074 LGYRLEGATKLTCLGGGRRVWSAPLPRCVAE---CGASVKGNEGTLLSPNFPSNYDNNHE 1130
Query: 327 CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV 386
C + I AG I L+ +F L D K VY+ S + LG F E ++
Sbjct: 1131 CIYKIETEAGKGIHLRTRSFQLFEGDTLK-----VYDGKDSSS-RPLGTFTKNELLGLIL 1184
Query: 387 -SSHHELAVLFRTDHGISSGGFSATYLAFN 415
S+ + L + F T+ + GF TY +F+
Sbjct: 1185 NSTSNHLWLEFNTNGSDTDQGFQLTYTSFD 1214
Score = 69.7 bits (169), Expect = 7e-12
Identities = 41/117 (35%), Positives = 58/117 (49%), Gaps = 5/117 (4%)
Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
+AK CGG + G GT +P + YP+ CTW I + I+L FH F+LE
Sbjct: 26 AAKGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED--- 82
Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
FD + VY+ +L R G + P +VS+ L + F TD +S+ GF A Y
Sbjct: 83 -FDILSVYDGQPQQG-NLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALY 137
Score = 35.4 bits (80), Expect = 0.14
Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 10/127 (7%)
Query: 132 QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
Q G P+ ++ C + +G G SP YP Y + C W I+V ++ I + ++
Sbjct: 2308 QFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF 2367
Query: 190 SIESVASCLFDRLELSPEPEG--PLLRVC--GRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
E FD LE+ G PLL V + ++ L + + +D + G
Sbjct: 2368 QSEK----QFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKG 2423
Query: 246 FHAWYQA 252
F Y A
Sbjct: 2424 FKIRYAA 2430
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 122 bits (305), Expect = 1e-27
Identities = 103/383 (26%), Positives = 150/383 (39%), Gaps = 73/383 (19%)
Query: 134 SGVSPSPQSTCGGL---LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALS 190
SGVS + CG + P G +SP +P YP +C W I+ I + +
Sbjct: 41 SGVS----TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
Query: 191 IESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
I+ C D L + R CG PP ++ H+ + F SD ++ GF Y
Sbjct: 97 IQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
Query: 251 QAMAPGRGSCAHDEFRC----------------------DQLICL--------------- 273
+ +CA D+FRC D+ IC
Sbjct: 157 FSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCA 216
Query: 274 ----------------LPDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
LP+S+ CDG +C D DE +C CG L GTF++P+
Sbjct: 217 YNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPN 274
Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRF 376
Y YP CTW I + L+F +F L+ DYV++Y+ LL
Sbjct: 275 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVL 332
Query: 377 CG--AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GC 433
+ P +VSS ++ V F D ++ GF+ATY + C P E+ C GC
Sbjct: 333 TAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGC 388
Query: 434 KGVQWMCDMWRDCTDGSDD-NCS 455
Q CD + C +G D+ NC+
Sbjct: 389 YTEQQRCDGYWHCPNGRDETNCT 411
Score = 90.1 bits (222), Expect = 5e-18
Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 12/189 (6%)
Query: 286 ADGSDETNCSAKFSGCGGN---LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQ 342
A+ S+ + S + CG + G ++P + +YP ++ C+W I G I +
Sbjct: 32 AEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITIS 91
Query: 343 FHNFSLEAQDECKFDY--VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
F +F ++ C D+ +E Y+ S R CG+ PP +SS + + F +D
Sbjct: 92 FQDFDIQGSRRCNLDWLTIETYKNIESY------RACGSTIPPPYISSQDHIWIRFHSDD 145
Query: 401 GISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLF 459
IS GF Y + + E C + C G C W C+ +C D SD+ C+
Sbjct: 146 NISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEAN 205
Query: 460 PPPELACEP 468
PP A +P
Sbjct: 206 PPTAAAFQP 214
Score = 38.1 bits (87), Expect = 0.022
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
C P C+ C W+CD DC DGSD +NC P+ P + V + GL
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 506
Score = 37.0 bits (84), Expect = 0.050
Identities = 15/35 (42%), Positives = 17/35 (48%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
C F C C+ VCD +C DGSDE NC
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 121 bits (304), Expect = 2e-27
Identities = 111/393 (28%), Positives = 142/393 (36%), Gaps = 76/393 (19%)
Query: 142 STCGGLL---SGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
+ C G L + RG SP +P YPP T+C W+IQ I + +E C
Sbjct: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
Query: 199 FDRLELSPE--PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF--GFHAWYQAMA 254
D L L P P R+CG PP + H+ + F SD+S G GF Y
Sbjct: 101 LDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160
Query: 255 PGRGSCAHDEFRCDQLICLL---------------------------PDSV--------- 278
G+ SC DEFRCD CL P S+
Sbjct: 161 LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCS 220
Query: 279 -------------CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYL--QQYPH 323
CDG +C DGSDE C CG L G+F++P + P
Sbjct: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPD--LACGRRLGSFYGSFASPDLFGAARGPS 278
Query: 324 QLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG--RFCGAEP 381
L CTW + + LQ L + DYV+VYE LL +
Sbjct: 279 DLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQTLSYRSNHR 332
Query: 382 PPHLVSSHHELAVLFRTDHGISSGGFSATYLAFN---ATENPCGPSELSCQAG----GCK 434
P L ++ L V + + GF+ATY E PCG S S GC
Sbjct: 333 PVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF 392
Query: 435 GVQWMCDMWRDCTDGSDDNCSGPLFPPPELACE 467
CD W C G D+ P PP + CE
Sbjct: 393 SEPQRCDGWWHCASGRDEQ-GCPACPPDQYPCE 424
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/176 (24%), Positives = 62/176 (35%), Gaps = 12/176 (6%)
Query: 130 GQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY--PPNTHCVWHIQVATDHAIQLKIE 187
G E+G P CG L G F+SP+ P + HC W + + L++E
Sbjct: 243 GSDEAGC---PDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLE 299
Query: 188 ALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFH 247
+++ L + L P +L L V + + + G GF+
Sbjct: 300 LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFN 359
Query: 248 AWYQAMA-------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
A YQ P S D C CDG+ +CA G DE C A
Sbjct: 360 ATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA 415
Score = 37.4 bits (85), Expect = 0.038
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
SC F C +C+ CDG +C DGSDE C A
Sbjct: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
Score = 33.1 bits (74), Expect = 0.72
Identities = 13/33 (39%), Positives = 15/33 (45%)
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
C P C C W CD DC DGSD++
Sbjct: 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEH 487
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 121 bits (303), Expect = 2e-27
Identities = 87/331 (26%), Positives = 143/331 (43%), Gaps = 70/331 (21%)
Query: 155 FSSPNYPD-PYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE----LSPEPE 209
F++P +PD PYP + C W ++ D + L + + S D + LSP
Sbjct: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287
Query: 210 GPLLRVCGRVPPP---TLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFR 266
L+++CG PP T +++ + LL+ ++++ GF A + +
Sbjct: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLP------------ 335
Query: 267 CDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
+ S CGG L QGTF++P Y YP +
Sbjct: 336 ------------------------------RMSSCGGRLRKAQGTFNSPYYPGHYPPNID 365
Query: 327 CTWHISVPAGHSIELQFHNFSL----EAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPP 382
CTW+I VP ++++F F L C DYVE+ ++CG
Sbjct: 366 CTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGE----------KYCGERSQ 415
Query: 383 PHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDM 442
+ S+ +++ V F +D + GF A YL++++++ PC P + +C+ G C + CD
Sbjct: 416 FVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSD-PC-PGQFTCRTGRCIRKELRCDG 473
Query: 443 WRDCTDGSDD-NCS---GPLFPPPELACEPV 469
W DCTD SD+ NCS G F C+P+
Sbjct: 474 WADCTDHSDELNCSCDAGHQFTCKNKFCKPL 504
Score = 85.9 bits (211), Expect = 9e-17
Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 12/158 (7%)
Query: 142 STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI----ESVASC 197
S+CGG L +G F+SP YP YPPN C W+I+V + ++++ + + +C
Sbjct: 338 SSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTC 397
Query: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
D +E++ E + CG + +N++ + V F SD S GF A Y ++
Sbjct: 398 PKDYVEINGE------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEY--LSYDS 449
Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCS 295
+F C C+ + CDG+A+C D SDE NCS
Sbjct: 450 SDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS 487
Score = 38.5 bits (88), Expect = 0.017
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
SC FRC CL C+G +C DGSDE +C
Sbjct: 524 SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Score = 34.7 bits (78), Expect = 0.25
Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 259 SCAHDEFRCDQLICLLPDSV-CDGFANCADGSDETNC 294
+C +RC +CL + CDG +C+DGSDE +C
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 121 bits (303), Expect = 2e-27
Identities = 97/366 (26%), Positives = 143/366 (39%), Gaps = 66/366 (18%)
Query: 148 LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPE 207
+ P G +SP +P YP +C W I+ I + + I+ C D L +
Sbjct: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
Query: 208 PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRC 267
R CG PP ++ H+ + F SD ++ GF Y + +CA D+FRC
Sbjct: 95 KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
Query: 268 ----------------------DQLICL-------------------------------L 274
D+ IC L
Sbjct: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214
Query: 275 PDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISV 333
P+S+ CDG +C D DE +C CG L GTF++P+Y YP CTW I
Sbjct: 215 PESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDT 272
Query: 334 PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCG--AEPPPHLVSSHHE 391
+ L+F +F L+ DYV++Y+ LL + P +VSS +
Sbjct: 273 GDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQ 330
Query: 392 LAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GCKGVQWMCDMWRDCTDGS 450
+ V F D ++ GF+ATY + C P E+ C GC Q CD + C +G
Sbjct: 331 IRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386
Query: 451 DD-NCS 455
D+ NC+
Sbjct: 387 DETNCT 392
Score = 87.0 bits (214), Expect = 4e-17
Identities = 46/162 (28%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 310 GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY--VEVYETSSS 367
G ++P + +YP ++ C+W I G I + F +F ++ C D+ +E Y+ S
Sbjct: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 99
Query: 368 GAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELS 427
R CG+ PP +SS + + F +D IS GF Y + + E C +
Sbjct: 100 Y------RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
Query: 428 CQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLFPPPELACEP 468
C G C W C+ +C D SD+ C+ PP A +P
Sbjct: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
Score = 76.3 bits (186), Expect = 7e-14
Identities = 49/158 (31%), Positives = 71/158 (44%), Gaps = 9/158 (5%)
Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVA----SCL 198
TCG L G F+SPNYPD YPP ++C W I + L+ ++ +
Sbjct: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 298
Query: 199 FDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
+D LE +P +L P T+ +++ + V F +D GF+A YQ G
Sbjct: 299 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV----DG 354
Query: 259 SCAHDEFRC-DQLICLLPDSVCDGFANCADGSDETNCS 295
C E C C CDG+ +C +G DETNC+
Sbjct: 355 FCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT 392
Score = 38.1 bits (87), Expect = 0.022
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
C P C+ C W+CD DC DGSD +NC P+ P + V + GL
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 487
Score = 37.0 bits (84), Expect = 0.050
Identities = 15/35 (42%), Positives = 17/35 (48%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
C F C C+ VCD +C DGSDE NC
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 109 bits (272), Expect = 8e-24
Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)
Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
V P CGG L S G+ +SP YP YP + +C W + + I L
Sbjct: 20 VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79
Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
C +D +E+ E L + CG + PPT+ ++ S L + F SD + +G GF Y
Sbjct: 80 KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
+ G C+ N T G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158
Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
T +P + ++YPH L CT+ I I LQF F LE + +CK+D++++++
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217
Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
L+G++CG + P L SS L++ F TD ++ GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 73.2 bits (178), Expect = 6e-13
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
CGG L G ++P Y Q YP C W + P I L F+ +F +E D CK+D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
++E+ + S A LLG+ CG PP ++SS L + F +D+ GFS Y F
Sbjct: 87 FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 418 ENPC 421
C
Sbjct: 146 SEDC 149
>gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Homo
sapiens]
Length = 525
Score = 107 bits (266), Expect = 4e-23
Identities = 91/331 (27%), Positives = 139/331 (41%), Gaps = 43/331 (12%)
Query: 132 QESGVSPSPQSTCG-GLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKI-EAL 189
Q G+ P + CG + + G F+SPNYPD YPPN C++ ++ A I+L E
Sbjct: 33 QNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHY 92
Query: 190 SIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGF 246
IE C FD LE+ P G PL+ R CG PP + + + + F SD +EG GF
Sbjct: 93 YIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGF 152
Query: 247 HAWYQAMAPGRGSCAHDEFRCDQLICLLPD---SVCDGFANCADGSDETNCSAKFSGCGG 303
A Y +PD + G N +C + SG G
Sbjct: 153 RAKYS---------------------FIPDPDFTYLGGILN-----PIPDCQFELSGADG 186
Query: 304 NLTGLQGTFSTPSYLQQYPHQLL-CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVY 362
+ Q + P Q + C W I I L+F ++ +E +ECK ++V VY
Sbjct: 187 IVRSSQ----VEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVY 242
Query: 363 ETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
+ SSS +L +FC ++ + + ++ D G F + +F E PC
Sbjct: 243 DGSSS-IENLKAKFCSTVANDVMLKTGIGVIRMW-ADEGSRLSRFRMLFTSF--VEPPCT 298
Query: 423 PSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
S C + C +C+ ++C D+N
Sbjct: 299 SSTFFCHSNMCINNSLVCNGVQNCAYPWDEN 329
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 6/146 (4%)
Query: 271 ICLLPDSVCDGFANCADGSDETNCSAKF---SGCGGNL-TGLQGTFSTPSYLQQYPHQLL 326
+ L+ V +G A D N K + CG + T G F++P+Y YP
Sbjct: 12 VLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKE 71
Query: 327 CTWHISVPAGHSIELQF-HNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHL 385
C + + IEL F ++ +E EC+FD++EV + G L+ R+CG + PP +
Sbjct: 72 CIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRD-GPFGFSPLIDRYCGVKSPPLI 130
Query: 386 VSSHHELAVLFRTDHGISSGGFSATY 411
S+ + + F +D + GF A Y
Sbjct: 131 RSTGRFMWIKFSSDEELEGLGFRAKY 156
Score = 33.5 bits (75), Expect = 0.55
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC-SAKFSGCGGNLTGLQGT 311
C F C +C+ VC+G NCA DE +C K +G +T GT
Sbjct: 297 CTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGT 349
>gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3
precursor [Homo sapiens]
Length = 533
Score = 102 bits (255), Expect = 7e-22
Identities = 88/336 (26%), Positives = 145/336 (43%), Gaps = 37/336 (11%)
Query: 124 AAGTPKGQQESGVSPSPQST-CGGLLSGPRG-FFSSPNYPDPYPPNTHCVWHIQVATDHA 181
+ T KG ++ S + +S CG G F+SPNYP YPP+ C++ I+ A
Sbjct: 20 SGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQC 79
Query: 182 IQLKI-EALSIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVS 237
I+L E SIE C FD +E+ P G P++ R CG+ PP + ++ L + F +
Sbjct: 80 IELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFA 139
Query: 238 DSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
D +E GF A Y +F+ L L P C+ ++G E+ K
Sbjct: 140 DGELESMGFSARY-------NFTPDPDFK--DLGALKPLPACEFEMGGSEGIVESIQIMK 190
Query: 298 FSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFD 357
G T + + C W+I P I L+F ++ ++ +ECK +
Sbjct: 191 ----EGKATASEA--------------VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRN 232
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
+V VY+ SSS L +FC ++ + + ++ D G + F + +F
Sbjct: 233 FVAVYDGSSS-VEDLKAKFCSTVANDVMLRTGLGVIRMW-ADEGSRNSRFQMLFTSFQ-- 288
Query: 418 ENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
E PC + C + C +C+ ++C D+N
Sbjct: 289 EPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDEN 324
Score = 31.2 bits (69), Expect = 2.7
Identities = 13/38 (34%), Positives = 18/38 (47%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
C + F C +C+ VC+G NC DE +C K
Sbjct: 292 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK 329
>gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2
precursor [Homo sapiens]
Length = 532
Score = 102 bits (255), Expect = 7e-22
Identities = 88/336 (26%), Positives = 145/336 (43%), Gaps = 37/336 (11%)
Query: 124 AAGTPKGQQESGVSPSPQST-CGGLLSGPRG-FFSSPNYPDPYPPNTHCVWHIQVATDHA 181
+ T KG ++ S + +S CG G F+SPNYP YPP+ C++ I+ A
Sbjct: 19 SGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQC 78
Query: 182 IQLKI-EALSIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVS 237
I+L E SIE C FD +E+ P G P++ R CG+ PP + ++ L + F +
Sbjct: 79 IELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFA 138
Query: 238 DSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
D +E GF A Y +F+ L L P C+ ++G E+ K
Sbjct: 139 DGELESMGFSARY-------NFTPDPDFK--DLGALKPLPACEFEMGGSEGIVESIQIMK 189
Query: 298 FSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFD 357
G T + + C W+I P I L+F ++ ++ +ECK +
Sbjct: 190 ----EGKATASEA--------------VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRN 231
Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
+V VY+ SSS L +FC ++ + + ++ D G + F + +F
Sbjct: 232 FVAVYDGSSS-VEDLKAKFCSTVANDVMLRTGLGVIRMW-ADEGSRNSRFQMLFTSFQ-- 287
Query: 418 ENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
E PC + C + C +C+ ++C D+N
Sbjct: 288 EPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDEN 323
Score = 31.2 bits (69), Expect = 2.7
Identities = 13/38 (34%), Positives = 18/38 (47%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
C + F C +C+ VC+G NC DE +C K
Sbjct: 291 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK 328
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 96.7 bits (239), Expect = 5e-20
Identities = 57/190 (30%), Positives = 93/190 (48%), Gaps = 37/190 (19%)
Query: 426 LSCQAGGCKGVQWMCDMWRDCTDGSD------------------------DNCSGPLFPP 461
+ C+ G C + CD DC DGSD D+C G
Sbjct: 385 VECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCD 444
Query: 462 PELA------CEPVQVEMCLGLSYNTTAFPNIWVGMITQEE--VVEVLSGYKSLTSLPCY 513
P + CEP+ +E+C+ L YN+T++PN + G TQ+E + S + +L CY
Sbjct: 445 PNNSLNNCSQCEPITLELCMNLPYNSTSYPN-YFGHRTQKEASISWESSLFPALVQTNCY 503
Query: 514 QHFRRLLCGLLVPRC-TPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEA 570
++ C +LVP+C G +PPCR++C+ ++ +C+S L ++G WP +C++ PE
Sbjct: 504 KYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEE 563
Query: 571 -ADLEACAQP 579
+D + C P
Sbjct: 564 NSDNQTCLMP 573
Score = 53.9 bits (128), Expect = 4e-07
Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 5/100 (5%)
Query: 465 ACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLL 524
AC + C L Y+ T P + V + E+ + L + L L CYQH C L
Sbjct: 138 ACMNITHSQCQMLPYHATLTPLLSV--VRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLA 195
Query: 525 VPRCTPLGSV---LPPCRSVCQEAEHQCQSGLALLGTPWP 561
P C G L PCRS C+ A+ C+S L ++ WP
Sbjct: 196 FPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWP 235
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 10/68 (14%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
C+ F+C C+L CDG A+C D SDE NC K + + PS Q
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK----------ERDLWECPSNKQ 629
Query: 320 QYPHQLLC 327
H ++C
Sbjct: 630 CLKHTVIC 637
Score = 39.3 bits (90), Expect = 0.010
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
C DE C C+ D CDG A+C+D SDE +C
Sbjct: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 264 EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300
E RC C+ + VCDG +C D SDE NCS G
Sbjct: 347 EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383
Score = 38.1 bits (87), Expect = 0.022
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
+C+ + F C CL VCDG+ +C D SDE NC
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340
Score = 36.2 bits (82), Expect = 0.085
Identities = 17/37 (45%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 421 CGPS-ELSCQAGGCKGVQWMCDMWRDCTDGSDD-NCS 455
C P+ E C G C ++W+CD DC D SD+ NCS
Sbjct: 342 CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Score = 34.3 bits (77), Expect = 0.32
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 272 CLLPDSVCDGFANCADGSDETNCSAKFSGC 301
C+ CDG +C DGSDE NCS + C
Sbjct: 392 CIPSTFQCDGDEDCKDGSDEENCSVIQTSC 421
Score = 34.3 bits (77), Expect = 0.32
Identities = 15/35 (42%), Positives = 18/35 (51%), Gaps = 1/35 (2%)
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNC 454
C PS C++G C CD DC D SD +NC
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
Score = 33.5 bits (75), Expect = 0.55
Identities = 13/24 (54%), Positives = 15/24 (62%)
Query: 272 CLLPDSVCDGFANCADGSDETNCS 295
CL +CDGF +C D DE NCS
Sbjct: 630 CLKHTVICDGFPDCPDYMDEKNCS 653
Score = 30.0 bits (66), Expect = 6.1
Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 4/49 (8%)
Query: 415 NATENPCGPSE-LSCQAGGCKGVQWMCDMWRDCTDGSDD---NCSGPLF 459
N + CG E C +G C + C+ + DC D SD+ NCS LF
Sbjct: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLF 311
Score = 29.6 bits (65), Expect = 7.9
Identities = 13/35 (37%), Positives = 17/35 (48%), Gaps = 1/35 (2%)
Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDD-NC 454
C + C G C +CD + DC D SD+ NC
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 94.0 bits (232), Expect = 3e-19
Identities = 70/269 (26%), Positives = 109/269 (40%), Gaps = 53/269 (19%)
Query: 153 GFFSSPNYPDPYPPNTHCVWHIQVATDHA-IQLKIEALSIESVASCLFDRLEL-SPEPEG 210
G+ +SP YP Y P+ C W IQ + I + C +D +E+ E E
Sbjct: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96
Query: 211 PLLR--VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCD 268
R CG++ PP + ++ L + FVSD G GF Y+ G
Sbjct: 97 GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRG------------ 144
Query: 269 QLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
P+ C N T G +P + ++YP+ L CT
Sbjct: 145 ------PE------------------------CSQNYTTPSGVIKSPGFPEKYPNSLECT 174
Query: 329 WHISVPAGHSIELQFHNFSLEAQDE------CKFDYVEVYETSSSGAFSLLGRFCGAEPP 382
+ + P I L+F +F LE C++D +E+++ +GR+CG + P
Sbjct: 175 YIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD-GFPDVGPHIGRYCGQKTP 233
Query: 383 PHLVSSHHELAVLFRTDHGISSGGFSATY 411
+ SS L+++F TD I+ GFSA Y
Sbjct: 234 GRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Score = 60.5 bits (145), Expect = 4e-09
Identities = 40/108 (37%), Positives = 57/108 (52%), Gaps = 6/108 (5%)
Query: 310 GTFSTPSYLQQYPHQLLCTWHISVPAGHS-IELQFH-NFSLEAQDECKFDYVEVYE-TSS 366
G ++P Y Y C W I P + I + F+ +F LE +D CK+DYVEV++ +
Sbjct: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
Query: 367 SGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
+G F G+FCG PP +VSS L + F +D+ GFS Y F
Sbjct: 96 NGHFR--GKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141
Score = 56.6 bits (135), Expect = 6e-08
Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 22/165 (13%)
Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS------C 197
C + P G SP +P+ YP + C + + I L+ E+ +E ++ C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 198 LFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA 254
+DRLE+ P+ + R CG+ P + +++ L +VF +DS++ GF A Y +
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 255 PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
S ++F+C + + G + SD+ S+++S
Sbjct: 267 ----SSVSEDFKCMEAL---------GMESGEIHSDQITASSQYS 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,300,456
Number of Sequences: 37866
Number of extensions: 1623919
Number of successful extensions: 9158
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 6810
Number of HSP's gapped (non-prelim): 1958
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.