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Search of human proteins with 66773086
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66773086 SH3-binding kinase 1 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66773086 SH3-binding kinase 1 [Homo sapiens] 867 0.0
gi|157676320 SH3-binding domain kinase family, member 2 [Homo sa... 213 3e-55
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 131 1e-30
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 126 3e-29
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 126 3e-29
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 126 3e-29
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 126 3e-29
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 125 7e-29
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 125 9e-29
gi|166295196 checkpoint kinase 1 [Homo sapiens] 123 3e-28
gi|166295194 checkpoint kinase 1 [Homo sapiens] 123 3e-28
gi|166295192 checkpoint kinase 1 [Homo sapiens] 123 3e-28
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 121 1e-27
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 121 1e-27
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 121 1e-27
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 121 1e-27
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 121 1e-27
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 117 2e-26
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 117 2e-26
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 115 8e-26
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 115 1e-25
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 113 3e-25
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 113 3e-25
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 113 3e-25
gi|32455269 serine/threonine kinase 32C [Homo sapiens] 113 3e-25
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 113 4e-25
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens] 113 4e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 112 5e-25
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 112 6e-25
gi|116256471 SNF1-like kinase [Homo sapiens] 112 8e-25
>gi|66773086 SH3-binding kinase 1 [Homo sapiens]
Length = 424
Score = 867 bits (2239), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG 60
MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG
Sbjct: 1 MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG 60
Query: 61 KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET 120
KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET
Sbjct: 61 KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET 120
Query: 121 EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV 180
EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV
Sbjct: 121 EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV 180
Query: 181 LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG 240
LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG
Sbjct: 181 LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG 240
Query: 241 VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP 300
VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP
Sbjct: 241 VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP 300
Query: 301 ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG 360
ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG
Sbjct: 301 ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG 360
Query: 361 SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI 420
SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI
Sbjct: 361 SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI 420
Query: 421 EICV 424
EICV
Sbjct: 421 EICV 424
>gi|157676320 SH3-binding domain kinase family, member 2 [Homo
sapiens]
Length = 348
Score = 213 bits (542), Expect = 3e-55
Identities = 117/273 (42%), Positives = 159/273 (58%), Gaps = 3/273 (1%)
Query: 34 EDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKN 93
EDM L+ +TL ++V + YE VR LG+G YG+V LV ++ GT +ALK + K +T L+
Sbjct: 43 EDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRG 102
Query: 94 FLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKR 153
FL E + SL + I+ + + E+ Y F E GDL I P+VGLP+ V R
Sbjct: 103 FLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHR 162
Query: 154 CVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIP 213
C QL AL+++H R LV+RD+KPENVL+ D CRR KL DFG TR G ++ IP
Sbjct: 163 CAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIP 222
Query: 214 YTAPEVC-QAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWE-AASGADAFFEEFVRWQR 271
YTAPE+C +GL + +D WA GVL+FC+LTG FPW+ + AD F+E+F+ WQ
Sbjct: 223 YTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQA 282
Query: 272 GRLP-GLPSQWRRFTEPALRMFQRLLALEPERR 303
P P W A + + LL P RR
Sbjct: 283 SGQPRDRPQPWFGLAPAADALLRGLLDPHPRRR 315
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 131 bits (330), Expect = 1e-30
Identities = 94/272 (34%), Positives = 142/272 (52%), Gaps = 13/272 (4%)
Query: 44 LAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVSIT 101
+ A++V KHYE R +G G + V ++ T A+K ++KS+ K K + E+ I
Sbjct: 347 IIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILII 406
Query: 102 NSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLA 161
SLS P I+K+ +V +ET+ EY GDLFD I V PE + L A
Sbjct: 407 QSLSH-PNIVKLHEV-YETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKA 464
Query: 162 LDFMHGRQLVHRDIKPENVLLFDRECR--RVKLADFGMTRRVGCRVKRVSGTIPYTAPEV 219
L MH + +VHRD+KPEN+L+ E + +KLADFG+ + V + V GT Y APE+
Sbjct: 465 LVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEI 524
Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
+ + GL VD+WA GV+++ +L G P+ + E F Q G LP
Sbjct: 525 L-SEKGYGLE----VDMWAAGVILYILLCGFPPFRSPERDQD--ELFNIIQLGHFEFLPP 577
Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
W ++ A + RLL ++P++R A +V +
Sbjct: 578 YWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQ 609
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 126 bits (317), Expect = 3e-29
Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ T L+ REV I L+ P
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
++VHRD+K EN+LL D + +K+ADFG + VG ++ G+ PY APE+ Q + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ +R L L P +RG +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 126 bits (317), Expect = 3e-29
Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ T L+ REV I L+ P
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
++VHRD+K EN+LL D + +K+ADFG + VG ++ G+ PY APE+ Q + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ +R L L P +RG +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 126 bits (317), Expect = 3e-29
Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ T L+ REV I L+ P
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
++VHRD+K EN+LL D + +K+ADFG + VG ++ G+ PY APE+ Q + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ +R L L P +RG +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 126 bits (317), Expect = 3e-29
Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ T L+ REV I L+ P
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
++VHRD+K EN+LL D + +K+ADFG + VG ++ G+ PY APE+ Q + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ +R L L P +RG +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 125 bits (314), Expect = 7e-29
Identities = 86/275 (31%), Positives = 149/275 (54%), Gaps = 24/275 (8%)
Query: 45 AASDVTKH---YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREV 98
+A+D H Y L + +GKG + KV L + TG ++A+K ++K++ T L+ REV
Sbjct: 49 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108
Query: 99 SITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQL 158
I L+ P I+K+F+V+ ETE EYA G++FD + + E + +Q+
Sbjct: 109 RIMKILNH-PNIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166
Query: 159 GLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTA 216
A+ + H + +VHRD+K EN+LL D + +K+ADFG + VG ++ G+ PY A
Sbjct: 167 VSAVQYCHQKYIVHRDLKAENLLL-DGD-MNIKIADFGFSNEFTVGNKLDTFCGSPPYAA 224
Query: 217 PEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPG 276
PE+ Q + DG VDVW+ GV+++ +++G+ P++ + + E V + R+P
Sbjct: 225 PELFQGKKYDG----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPF 278
Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
S + ++LL L P +RG +++ +
Sbjct: 279 YMS------TDCENLLKKLLVLNPIKRGSLEQIMK 307
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 125 bits (313), Expect = 9e-29
Identities = 85/265 (32%), Positives = 145/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L+R +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 58 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH-P 116
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA AG++FD + + E + +Q+ A+ + H +
Sbjct: 117 NIVKLFEVI-ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D E +K+ADFG + +G ++ G+ PY APE+ Q + D
Sbjct: 176 NIVHRDLKAENLLL-DAEA-NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 233
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VD+W+ GV+++ +++G+ P++ + E R RG+ +P E
Sbjct: 234 G----PEVDIWSLGVILYTLVSGSLPFDGHN----LKELRERVLRGKY-RVPFYMSTDCE 284
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
LR R L L P +R +++ +
Sbjct: 285 SILR---RFLVLNPAKRCTLEQIMK 306
>gi|166295196 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 123 bits (309), Expect = 3e-28
Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
++LV+ LG+G YG+V L V + T +A+K V+ + +N +E+ I N + + +
Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67
Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
+K + E Y+F EY G+LFD I P +G+PE +R QL + ++HG +
Sbjct: 68 VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126
Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
HRDIKPEN+LL +R+ +K++DFG+ R R + ++ GT+PY APE+ +
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184
Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
VDVW+ G+++ +L G PW+ S + +E+ W+ + P W++
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235
Query: 286 EPALRMFQRLLALEPERR 303
L + ++L P R
Sbjct: 236 SAPLALLHKILVENPSAR 253
>gi|166295194 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 123 bits (309), Expect = 3e-28
Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
++LV+ LG+G YG+V L V + T +A+K V+ + +N +E+ I N + + +
Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67
Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
+K + E Y+F EY G+LFD I P +G+PE +R QL + ++HG +
Sbjct: 68 VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126
Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
HRDIKPEN+LL +R+ +K++DFG+ R R + ++ GT+PY APE+ +
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184
Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
VDVW+ G+++ +L G PW+ S + +E+ W+ + P W++
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235
Query: 286 EPALRMFQRLLALEPERR 303
L + ++L P R
Sbjct: 236 SAPLALLHKILVENPSAR 253
>gi|166295192 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 123 bits (309), Expect = 3e-28
Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
++LV+ LG+G YG+V L V + T +A+K V+ + +N +E+ I N + + +
Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67
Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
+K + E Y+F EY G+LFD I P +G+PE +R QL + ++HG +
Sbjct: 68 VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126
Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
HRDIKPEN+LL +R+ +K++DFG+ R R + ++ GT+PY APE+ +
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184
Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
VDVW+ G+++ +L G PW+ S + +E+ W+ + P W++
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235
Query: 286 EPALRMFQRLLALEPERR 303
L + ++L P R
Sbjct: 236 SAPLALLHKILVENPSAR 253
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 121 bits (303), Expect = 1e-27
Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D + +K+ADFG + G ++ G+ PY APE+ Q + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ ++ L L P +RG +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 121 bits (303), Expect = 1e-27
Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D + +K+ADFG + G ++ G+ PY APE+ Q + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ ++ L L P +RG +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 121 bits (303), Expect = 1e-27
Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D + +K+ADFG + G ++ G+ PY APE+ Q + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ ++ L L P +RG +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 121 bits (303), Expect = 1e-27
Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D + +K+ADFG + G ++ G+ PY APE+ Q + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ ++ L L P +RG +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 121 bits (303), Expect = 1e-27
Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
+Y L++ +GKG + KV L + TG ++A+K ++K++ + L+ REV I L+ P
Sbjct: 19 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 77
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
I+K+F+V+ ETE EYA G++FD + + E + +Q+ A+ + H +
Sbjct: 78 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+K EN+LL D + +K+ADFG + G ++ G+ PY APE+ Q + D
Sbjct: 137 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 194
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
G VDVW+ GV+++ +++G+ P++ + + E V + R+P S
Sbjct: 195 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 242
Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
+ ++ L L P +RG +++ +
Sbjct: 243 DCENLLKKFLILNPSKRGTLEQIMK 267
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 117 bits (294), Expect = 2e-26
Identities = 110/393 (27%), Positives = 169/393 (43%), Gaps = 56/393 (14%)
Query: 42 RTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVS 99
R +S + + Y++ + +G G + V + + TG + ALK ++K+K K L EVS
Sbjct: 382 RCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVS 441
Query: 100 ITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLG 159
I + I+ V ++ TE E GDLFD I E V L
Sbjct: 442 ILRRVKHPNIIMLVEEMETATE--LFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLA 499
Query: 160 LALDFMHGRQLVHRDIKPENVLL--FDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAP 217
AL ++HG +VHRDIKPEN+L+ + + +KL DFG+ V + V GT Y AP
Sbjct: 500 NALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAP 559
Query: 218 EVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-ADAFFEEFVRWQRGRLPG 276
E+ A GL VD+WA GV+ + +L G P+ + + + F++ + G+L
Sbjct: 560 EII-AETGYGLK----VDIWAAGVITYILLCGFPPFRSENNLQEDLFDQIL---AGKLEF 611
Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRF------------LKHELTSELRRR 324
W T+ A + ++L + E R A ++ ++ E+T +L++
Sbjct: 612 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQ- 670
Query: 325 PSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG----------SGS------RPAPP 368
H P G + T L + G SG P PP
Sbjct: 671 --HFNNALPKQNSTTTG------VSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPP 722
Query: 369 AVGSVPLP---VPVPVPVPVPVPVPEPGLAPQG 398
+V +P+P VP P P P P P P AP G
Sbjct: 723 SVEEIPVPGEAVPAPTPPESPTPHPPPA-APGG 754
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 117 bits (294), Expect = 2e-26
Identities = 110/393 (27%), Positives = 169/393 (43%), Gaps = 56/393 (14%)
Query: 42 RTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVS 99
R +S + + Y++ + +G G + V + + TG + ALK ++K+K K L EVS
Sbjct: 383 RCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVS 442
Query: 100 ITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLG 159
I + I+ V ++ TE E GDLFD I E V L
Sbjct: 443 ILRRVKHPNIIMLVEEMETATE--LFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLA 500
Query: 160 LALDFMHGRQLVHRDIKPENVLL--FDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAP 217
AL ++HG +VHRDIKPEN+L+ + + +KL DFG+ V + V GT Y AP
Sbjct: 501 NALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAP 560
Query: 218 EVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-ADAFFEEFVRWQRGRLPG 276
E+ A GL VD+WA GV+ + +L G P+ + + + F++ + G+L
Sbjct: 561 EII-AETGYGLK----VDIWAAGVITYILLCGFPPFRSENNLQEDLFDQIL---AGKLEF 612
Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRF------------LKHELTSELRRR 324
W T+ A + ++L + E R A ++ ++ E+T +L++
Sbjct: 613 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQ- 671
Query: 325 PSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG----------SGS------RPAPP 368
H P G + T L + G SG P PP
Sbjct: 672 --HFNNALPKQNSTTTG------VSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPP 723
Query: 369 AVGSVPLP---VPVPVPVPVPVPVPEPGLAPQG 398
+V +P+P VP P P P P P P AP G
Sbjct: 724 SVEEIPVPGEAVPAPTPPESPTPHPPPA-APGG 755
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 115 bits (288), Expect = 8e-26
Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 21/256 (8%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSPF 109
Y++ LGKG + V L ++ T T++A+K ++KS+ L+ REV I L P
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH-PH 78
Query: 110 IIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQ 169
IIK++ V+ ET+ EYA G++FD + L E +R Q+ A+D+ HGR+
Sbjct: 79 IIKLYQVM-ETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
Query: 170 LVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADG 227
+VHRD+K EN+LL + +K+ADFG + G + G+ PY APEV + + +G
Sbjct: 138 IVHRDLKAENLLLDNN--MNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
Query: 228 LAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEP 287
+D+W+ GV+++ ++ G P++ + + V R R+P S E
Sbjct: 196 ----PQLDIWSMGVVLYVLVCGALPFDGPT--LPILRQRVLEGRFRIPYFMS------ED 243
Query: 288 ALRMFQRLLALEPERR 303
+ +R+L L+P +R
Sbjct: 244 CEHLIRRMLVLDPSKR 259
Score = 28.9 bits (63), Expect = 9.2
Identities = 17/38 (44%), Positives = 18/38 (47%), Gaps = 2/38 (5%)
Query: 359 SGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAP 396
S SG R APP L P P P P P +PG AP
Sbjct: 804 STSGPRAAPPL--PTQLQQQQPPPPPPPPPPRQPGAAP 839
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 115 bits (287), Expect = 1e-25
Identities = 87/277 (31%), Positives = 141/277 (50%), Gaps = 22/277 (7%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVS--ITN-SLSSSP 108
HY L LG GT+GKV + ++ TG K+A+K +N+ K + + + ++ I N L P
Sbjct: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74
Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
IIK++ V+ D ++ EY G+LFD I + E +R QQ+ A+D+ H
Sbjct: 75 HIIKLYQVISTPTDFFM-VMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133
Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRVSGTIPYTAPEVCQAGRAD 226
+VHRD+KPENVLL K+ADFG++ + G ++ G+ Y APEV +GR
Sbjct: 134 MVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI-SGR-- 188
Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
L VD+W+ GV+++ +L G P++ D + RG + +P R
Sbjct: 189 -LYAGPEVDIWSCGVILYALLCGTLPFD-----DEHVPTLFKKIRGGVFYIPEYLNR--- 239
Query: 287 PALRMFQRLLALEPERRGPAKEV--FRFLKHELTSEL 321
+ +L ++P +R K++ + K +L S L
Sbjct: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 113 bits (283), Expect = 3e-25
Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 22/272 (8%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLK---------NFLREVSITNS 103
Y + + LG G G+V L + T K+A+K ++K K + N E+ I
Sbjct: 263 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 322
Query: 104 LSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALD 163
L+ P IIK+ + F+ ED Y+ E G+LFD + L E T K Q+ LA+
Sbjct: 323 LNH-PCIIKIKNF-FDAEDYYIVL-ELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 379
Query: 164 FMHGRQLVHRDIKPENVLLFDRE--CRRVKLADFGMTRRVG--CRVKRVSGTIPYTAPEV 219
++H ++HRD+KPENVLL +E C +K+ DFG ++ +G ++ + GT Y APEV
Sbjct: 380 YLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 438
Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
+ G + VD W+ GV++F L+G P+ + ++ G+ +P
Sbjct: 439 LVSVGTAG--YNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT---SGKYNFIPE 493
Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
W +E AL + ++LL ++P+ R +E R
Sbjct: 494 VWAEVSEKALDLVKKLLVVDPKARFTTEEALR 525
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 113 bits (283), Expect = 3e-25
Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 22/272 (8%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLK---------NFLREVSITNS 103
Y + + LG G G+V L + T K+A+K ++K K + N E+ I
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
Query: 104 LSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALD 163
L+ P IIK+ + F+ ED Y+ E G+LFD + L E T K Q+ LA+
Sbjct: 280 LNH-PCIIKIKNF-FDAEDYYIVL-ELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
Query: 164 FMHGRQLVHRDIKPENVLLFDRE--CRRVKLADFGMTRRVG--CRVKRVSGTIPYTAPEV 219
++H ++HRD+KPENVLL +E C +K+ DFG ++ +G ++ + GT Y APEV
Sbjct: 337 YLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 395
Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
+ G + VD W+ GV++F L+G P+ + ++ G+ +P
Sbjct: 396 LVSVGTAG--YNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT---SGKYNFIPE 450
Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
W +E AL + ++LL ++P+ R +E R
Sbjct: 451 VWAEVSEKALDLVKKLLVVDPKARFTTEEALR 482
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 113 bits (283), Expect = 3e-25
Identities = 85/301 (28%), Positives = 142/301 (47%), Gaps = 37/301 (12%)
Query: 41 LRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK-------TKLKN 93
+ T DV HYE+ ELG G + V KGTG + A KF+ K + +
Sbjct: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60
Query: 94 FLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKR 153
REV+I + P II + D+ FE + V E G+LFD + + L ED +
Sbjct: 61 IEREVNILREIRH-PNIITLHDI-FENKTDVVLILELVSGGELFDFLAEKESLTEDEATQ 118
Query: 154 CVQQLGLALDFMHGRQLVHRDIKPENVLLFDREC--RRVKLADFGMTRRV--GCRVKRVS 209
++Q+ + ++H +++ H D+KPEN++L D+ R+KL DFG+ ++ G K +
Sbjct: 119 FLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIF 178
Query: 210 GTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPW------EAASGADAFF 263
GT + APE+ + L ++ D+W+ GV+ + +L+G P+ E + A
Sbjct: 179 GTPEFVAPEIV---NYEPLGLE--ADMWSIGVITYILLSGASPFLGETKQETLTNISAVN 233
Query: 264 EEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRR 323
+F + +E A +RLL +P+RR + + L+H +RR
Sbjct: 234 YDFDE----------EYFSNTSELAKDFIRRLLVKDPKRR---MTIAQSLEHSWIKAIRR 280
Query: 324 R 324
R
Sbjct: 281 R 281
>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
Length = 486
Score = 113 bits (283), Expect = 3e-25
Identities = 87/337 (25%), Positives = 155/337 (45%), Gaps = 46/337 (13%)
Query: 2 SVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTED-----------------------MQA 38
S G P P R P P P AG P + M A
Sbjct: 15 SPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSA 74
Query: 39 LTLRTLAASDVTK----HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKS----KTK 90
T R D H++++R +GKG++GKV +V + T A+K++NK + +
Sbjct: 75 ATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDE 134
Query: 91 LKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDT 150
++N RE+ I + F++ ++ + ED ++ + GDL + V EDT
Sbjct: 135 VRNVFRELEILQEIEHV-FLVNLWYSFQDEEDMFMVV-DLLLGGDLRYHLQQNVQFSEDT 192
Query: 151 VKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRV 208
V+ + ++ LALD++ G+ ++HRD+KP+N+LL +R L DF + + G R +
Sbjct: 193 VRLYICEMALALDYLRGQHIIHRDVKPDNILLDER--GHAHLTDFNIATIIKDGERATAL 250
Query: 209 SGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWE--AASGADAFFEEF 266
+GT PY APE+ + G VD W+ GV+ + +L G P++ +++ ++ + F
Sbjct: 251 AGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLF 310
Query: 267 VRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERR 303
+P +++ + + ++LL + PE R
Sbjct: 311 STVSVQYVP-------TWSKEMVALLRKLLTVNPEHR 340
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 113 bits (282), Expect = 4e-25
Identities = 84/263 (31%), Positives = 139/263 (52%), Gaps = 24/263 (9%)
Query: 6 PEPEPPR----SLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVT--KHYELVREL 59
P + PR SL GPG+ P + +L E ++T A S+ H+EL++ L
Sbjct: 20 PRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEI--SITHHVKAGSEKADPSHFELLKVL 77
Query: 60 GKGTYGKVDLV---VYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLS--SSPFIIKVF 114
G+G++GKV LV +G A+K + K+ K+++ +R + L+ + PF++K+
Sbjct: 78 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 137
Query: 115 DVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRD 174
F+TE ++ GDLF + +V E+ VK + +L L LD +H +++RD
Sbjct: 138 -YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRD 196
Query: 175 IKPENVLLFDRECRRVKLADFGMTRRVGCRVKRV---SGTIPYTAPEVCQAGRADGLAVD 231
+KPEN+LL D E +KL DFG+++ K+ GT+ Y APEV +
Sbjct: 197 LKPENILL-DEE-GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV-----VNRQGHS 249
Query: 232 TGVDVWAFGVLIFCVLTGNFPWE 254
D W++GVL+F +LTG+ P++
Sbjct: 250 HSADWWSYGVLMFEMLTGSLPFQ 272
Score = 98.2 bits (243), Expect = 1e-20
Identities = 80/297 (26%), Positives = 137/297 (46%), Gaps = 25/297 (8%)
Query: 36 MQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL 95
+Q L + L SD Y + +G G+Y + V+K T + A+K ++KSK ++
Sbjct: 413 VQQLHGKNLVFSD---GYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK---RDPS 466
Query: 96 REVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCV 155
E+ I P II + DV + + Y+ E G+L D I Q E +
Sbjct: 467 EEIEILLRYGQHPNIITLKDVYDDGKHVYLVT-ELMRGGELLDKILRQKFFSEREASFVL 525
Query: 156 QQLGLALDFMHGRQLVHRDIKPENVLLFDR----ECRRVKLADFGMTRRVGCR---VKRV 208
+G ++++H + +VHRD+KP N+L D EC R+ DFG +++ +
Sbjct: 526 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRI--CDFGFAKQLRAENGLLMTP 583
Query: 209 SGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVR 268
T + APEV + D G D+W+ G+L++ +L G P+ A +D E R
Sbjct: 584 CYTANFVAPEVLKR-----QGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTR 637
Query: 269 WQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRP 325
G+ W +E A + ++L ++P +R AK+V L+H ++ + P
Sbjct: 638 IGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQV---LQHPWVTQKDKLP 691
>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
Length = 396
Score = 113 bits (282), Expect = 4e-25
Identities = 74/258 (28%), Positives = 137/258 (53%), Gaps = 17/258 (6%)
Query: 52 HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK----TKLKNFLREVSITNSLSSS 107
H+E++R +GKG++GKV +V T A+K++NK K +++N +E+ I L
Sbjct: 22 HFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH- 80
Query: 108 PFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHG 167
PF++ ++ + ED ++ + GDL + V E+TVK + +L +ALD++
Sbjct: 81 PFLVNLWYSFQDEEDMFMVV-DLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 139
Query: 168 RQLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRVSGTIPYTAPEVCQAGRA 225
++++HRD+KP+N+LL E V + DF + + ++ ++GT PY APE+ + +
Sbjct: 140 QRIIHRDMKPDNILL--DEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 197
Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
G + VD W+ GV + +L G P+ S + +E V + PS W +
Sbjct: 198 AGYSF--AVDWWSLGVTAYELLRGRRPYHIRSSTSS--KEIVHTFETTVVTYPSAW---S 250
Query: 286 EPALRMFQRLLALEPERR 303
+ + + ++LL P++R
Sbjct: 251 QEMVSLLKKLLEPNPDQR 268
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 112 bits (281), Expect = 5e-25
Identities = 86/268 (32%), Positives = 140/268 (52%), Gaps = 28/268 (10%)
Query: 51 KH-YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK----LKNFLREVSITNSLS 105
KH YEL LGKGTYGKV + +G +A+K + K K K + + RE+ I +SL+
Sbjct: 52 KHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN 111
Query: 106 SSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFM 165
P II +++V FE +D V EYA G+L+D I + L E + +Q+ A+ +
Sbjct: 112 H-PHIISIYEV-FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYC 169
Query: 166 HGRQLVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAG 223
H +VHRD+K EN+LL D C +K+ADFG++ + ++ G+ Y +PE+
Sbjct: 170 HKNGVVHRDLKLENILL-DDNC-NIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGR 227
Query: 224 RADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRR 283
G VD+ WA GVL++ ++ G P+ D F + + Q ++R
Sbjct: 228 PYRGPEVDS----WALGVLLYTLVYGTMPF------DGFDHKNLIRQIS-----SGEYRE 272
Query: 284 FTEP--ALRMFQRLLALEPERRGPAKEV 309
T+P A + + +L + P+RR +++
Sbjct: 273 PTQPSDARGLIRWMLMVNPDRRATIEDI 300
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 112 bits (280), Expect = 6e-25
Identities = 96/325 (29%), Positives = 158/325 (48%), Gaps = 29/325 (8%)
Query: 18 GPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELV--RELGKGTYGKVDLVVYKGT 75
GP P P LLTE ++A+ +RT D Y L RELG+G + V + K +
Sbjct: 29 GPCRPPPPPQARGLLTE-IRAV-VRTEPFQD---GYSLCPGRELGRGKFAVVRKCIKKDS 83
Query: 76 GTKMALKFVNKSKTKLK---NFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAP 132
G + A KF+ K + + E+++ +P++I + +V +ET + EYA
Sbjct: 84 GKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEV-YETASEMILVLEYAA 142
Query: 133 AGDLFD--IIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLL-FDRECRR 189
G++FD + + E V+R ++Q+ + F+H R +VH D+KP+N+LL +
Sbjct: 143 GGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGD 202
Query: 190 VKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVL 247
+K+ DFG++R + ++ + GT Y APE+ + D+W+ GVL + +L
Sbjct: 203 IKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYD-----PISMATDMWSIGVLTYVML 257
Query: 248 TGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAK 307
TG P+ G D E F+ + L ++ +E A+ + LL +PE R A+
Sbjct: 258 TGISPF---LGNDK-QETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAE 313
Query: 308 EVFRFLKHE-LTSELRRRPSHRARK 331
E LKH LT + PS R K
Sbjct: 314 EC---LKHPWLTQSSIQEPSFRMEK 335
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 112 bits (279), Expect = 8e-25
Identities = 77/256 (30%), Positives = 136/256 (53%), Gaps = 21/256 (8%)
Query: 53 YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSPF 109
Y++ R LGKG + V L ++ T T++A+K ++K++ + L+ REV + L+ P
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH-PH 85
Query: 110 IIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQ 169
IIK++ V+ ET+D E+A G++FD + L E+ ++ Q+ A+++ H
Sbjct: 86 IIKLYQVM-ETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144
Query: 170 LVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADG 227
+VHRD+K EN+LL +KLADFG + G + G+ PY APEV + +G
Sbjct: 145 IVHRDLKTENLLLDGN--MDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
Query: 228 LAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEP 287
+D+W+ GV+++ ++ G+ P++ + + V R R+P SQ
Sbjct: 203 ----PQLDIWSLGVVLYVLVCGSLPFDGPNLPT--LRQRVLEGRFRIPFFMSQ------D 250
Query: 288 ALRMFQRLLALEPERR 303
+ +R+L ++P RR
Sbjct: 251 CESLIRRMLVVDPARR 266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,074,493
Number of Sequences: 37866
Number of extensions: 1355422
Number of successful extensions: 18362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 840
Number of HSP's that attempted gapping in prelim test: 8772
Number of HSP's gapped (non-prelim): 5885
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.