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Search of human proteins with 62241011
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62241011 AKT1 kinase [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62241015 AKT1 kinase [Homo sapiens] 986 0.0
gi|62241013 AKT1 kinase [Homo sapiens] 986 0.0
gi|62241011 AKT1 kinase [Homo sapiens] 986 0.0
gi|4502023 AKT2 kinase [Homo sapiens] 822 0.0
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 813 0.0
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 776 0.0
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 333 2e-91
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 333 2e-91
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 327 1e-89
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 327 2e-89
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 326 3e-89
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 326 3e-89
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 326 3e-89
gi|28557781 protein kinase C, eta [Homo sapiens] 324 1e-88
gi|4885563 protein kinase C, epsilon [Homo sapiens] 322 5e-88
gi|5453974 protein kinase N2 [Homo sapiens] 320 2e-87
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 315 6e-86
gi|133908623 protein kinase C, iota [Homo sapiens] 313 2e-85
gi|4506067 protein kinase C, alpha [Homo sapiens] 311 6e-85
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 311 8e-85
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 311 8e-85
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 310 1e-84
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 310 1e-84
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 300 1e-81
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 300 1e-81
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 300 1e-81
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 297 2e-80
gi|13384594 protein kinase C, gamma [Homo sapiens] 296 4e-80
gi|5453976 protein kinase C, theta [Homo sapiens] 291 9e-79
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 291 9e-79
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 986 bits (2550), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 986 bits (2550), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 986 bits (2550), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 822 bits (2123), Expect = 0.0
Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 3/479 (0%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+ DQ PLNNFSVA+C
Sbjct: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 118
QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW AIQ VA+ LK++ E+ M
Sbjct: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
Query: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
D++ GSPSD+S EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
Query: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
Query: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358
GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
Query: 359 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418
ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG DAKE+M+HRFF I WQ V +
Sbjct: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
Query: 419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477
KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+ ++ ++R HFPQFSYSAS
Sbjct: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 813 bits (2099), Expect = 0.0
Identities = 397/480 (82%), Positives = 433/480 (90%), Gaps = 5/480 (1%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+
Sbjct: 60 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
S DN G EEM+ S K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
ILME+I+FPRTL +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ--DDSMECVDSERRPHFPQFSYSASG 478
L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++ +D M+C+D+ERRPHFPQFSYSASG
Sbjct: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASG 477
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 776 bits (2004), Expect = 0.0
Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)
Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+
Sbjct: 60 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
S DN G EEM+ S K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
ILME+I+FPRTL +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460
L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++ +C
Sbjct: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 333 bits (854), Expect = 2e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 6 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 63
Query: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 64 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 123
Query: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 124 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 182
Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242
Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 301
Query: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 333 bits (854), Expect = 2e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 66 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 123
Query: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 124 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 183
Query: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 184 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 242
Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 243 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 302
Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 303 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 361
Query: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 362 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 327 bits (838), Expect = 1e-89
Identities = 186/440 (42%), Positives = 264/440 (60%), Gaps = 24/440 (5%)
Query: 41 RPQDVDQREAPLNN--FSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE 98
RP+ + EA + F ++ MK R N FI + + ++ + PE
Sbjct: 18 RPRHKKRAEAQKRSESFLLSGLAFMKQRRMGLNDFIQK------IANNSYACKHPE---- 67
Query: 99 WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGK 158
+Q++ + QE E M+ P S ++++ + + H ++F +LK++GK
Sbjct: 68 ----VQSILKISQPQEPELMNANPSPPP--SPSQQINLGPSSNPH-AKPSDFHFLKVIGK 120
Query: 159 GTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSF 217
G+FGKV+L + KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SF
Sbjct: 121 GSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSF 180
Query: 218 QTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277
QT D+L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK
Sbjct: 181 QTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKP 239
Query: 278 ENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 337
EN++LD GHI +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG
Sbjct: 240 ENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGA 299
Query: 338 VMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSE 397
V+YEM+ G PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +
Sbjct: 300 VLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKD 358
Query: 398 DAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDS 457
D EI H FF+ I W + KK++PPF P V+ D R+FD EFT + + + DS
Sbjct: 359 DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDS 418
Query: 458 MECVDS--ERRPHFPQFSYS 475
+ S E F FSY+
Sbjct: 419 VLVTASVKEAAEAFLGFSYA 438
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 327 bits (837), Expect = 2e-89
Identities = 169/395 (42%), Positives = 245/395 (62%), Gaps = 24/395 (6%)
Query: 88 FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141
F+V P E E ++ ++ G K EE+ + + S DN+G +
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335
Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RV
Sbjct: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
Query: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260
L + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI
Sbjct: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320
L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380
+ YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++
Sbjct: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572
Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
GL+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + DT FD+
Sbjct: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDK 632
Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYS 475
EFT Q + +TP D+ M +E F FSY+
Sbjct: 633 EFTRQPVELTPTDKLFIMNLDQNE----FAGFSYT 663
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 58 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 116
Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 117 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 176
Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 235
Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295
Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 354
Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 414
Query: 466 RPHFPQFSYS 475
F FSY+
Sbjct: 415 AEAFLGFSYA 424
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 86 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 144
Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 145 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 204
Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 205 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 263
Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323
Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 382
Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 442
Query: 466 RPHFPQFSYS 475
F FSY+
Sbjct: 443 AEAFLGFSYA 452
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 153 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 211
Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 271
Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 272 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 330
Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390
Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 449
Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 509
Query: 466 RPHFPQFSYS 475
F FSY+
Sbjct: 510 AEAFLGFSYA 519
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 324 bits (831), Expect = 1e-88
Identities = 155/316 (49%), Positives = 222/316 (70%), Gaps = 7/316 (2%)
Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202
+R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L
Sbjct: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
Query: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
+R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
+LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L
Sbjct: 468 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 526
Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381
++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 527 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
Query: 382 GLLKKDPKQRLGG---GSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
+ K+P RLG G E A I++H FF I W + +++ PPF+P++ S D F
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHA--ILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 644
Query: 439 DEEFTAQMITITPPDQ 454
D +F + +TP D+
Sbjct: 645 DPDFIKEEPVLTPIDE 660
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 322 bits (825), Expect = 5e-88
Identities = 170/364 (46%), Positives = 237/364 (65%), Gaps = 16/364 (4%)
Query: 119 DFRSGSPSDN---SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175
+ R+ S D S E EV + K R+ ++EF ++K+LGKG+FGKV+L + K
Sbjct: 375 EHRAASSPDGQLMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEV 433
Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234
YA+K+LKK+VI+ D+V T+TE R+L +R HP+LT L FQT DRL FVMEY NGG+
Sbjct: 434 YAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGD 493
Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
L F + R R F E R+RFY AE+ SAL +LH + V+YRDLKL+N++LD +GH K+ DFG
Sbjct: 494 LMFQIQRSRKFDEPRSRFYAAEVTSALMFLH-QHGVIYRDLKLDNILLDAEGHCKLADFG 552
Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354
+CKEGI +G T TFCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF +
Sbjct: 553 MCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNE 612
Query: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG----GGSEDAKEIMQHRFFAG 410
+ LFE IL +++ +P L EA S+L + K+P +RLG EDA I QH FF
Sbjct: 613 DDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDA--IKQHPFFKE 670
Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFP 470
I W + +KK+ PPFKP++ ++ D FD++FT + +T D+ V + F
Sbjct: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFK 726
Query: 471 QFSY 474
FSY
Sbjct: 727 GFSY 730
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 320 bits (819), Expect = 2e-87
Identities = 165/370 (44%), Positives = 233/370 (62%), Gaps = 8/370 (2%)
Query: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 169
L K + E S + SG +E+E ++ + + + +F +LG+G FGKV+L +
Sbjct: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
Query: 170 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ---NSRHPFLTALKYSFQTHDRLCFV 226
K T +A+K LKK IVA+DEV + E R+ + + RHPFL L FQT + +CFV
Sbjct: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
Query: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286
MEYA GG+L H+ + VFSE RA FY A +V L YLH K +VYRDLKL+NL+LD +G
Sbjct: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEG 794
Query: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346
+KI DFGLCKEG+ G TFCGTPE+LAPEVL + Y RAVDWWGLGV++YEM+ G
Sbjct: 795 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854
Query: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406
PF D E++F+ I+ +E+R+PR L EA S++ LL+++P++RLG +DA+++ +H
Sbjct: 855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914
Query: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466
FF I W + +KK+ PPF P + D FD+EFT++ +TPP + + E +
Sbjct: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREP---RILSEEEQ 971
Query: 467 PHFPQFSYSA 476
F F Y A
Sbjct: 972 EMFRDFDYIA 981
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 315 bits (807), Expect = 6e-86
Identities = 161/375 (42%), Positives = 233/375 (62%), Gaps = 21/375 (5%)
Query: 88 FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141
F+V P E E ++ ++ G K EE+ + + S DN+G +
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335
Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RV
Sbjct: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
Query: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260
L + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI
Sbjct: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320
L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380
+ YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++
Sbjct: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572
Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
GL+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + FD
Sbjct: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 631
Query: 441 EFTAQMITITPPDQD 455
FT +TPPDQ+
Sbjct: 632 FFTRHPPVLTPPDQE 646
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 313 bits (802), Expect = 2e-85
Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)
Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199
K + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE
Sbjct: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
Query: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
V Q S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI
Sbjct: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+AP
Sbjct: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369
E+L DYG +VDWW LGV+M+EMM GR PF N D + LF++IL ++IR P
Sbjct: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428
R+L +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP
Sbjct: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
Query: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
++ E FD +FT + + +T PD DD + +D + F F Y
Sbjct: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 311 bits (798), Expect = 6e-85
Identities = 148/312 (47%), Positives = 212/312 (67%), Gaps = 3/312 (0%)
Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
+LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 453 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 511
Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ G
Sbjct: 512 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 571
Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442
L+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V + FD+ F
Sbjct: 572 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFF 630
Query: 443 TAQMITITPPDQ 454
T +TPPDQ
Sbjct: 631 TRGQPVLTPPDQ 642
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 311 bits (797), Expect = 8e-85
Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)
Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
Query: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
TDFGLCKEGI T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
Query: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421
Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 311 bits (797), Expect = 8e-85
Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)
Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
Query: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
TDFGLCKEGI T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
Query: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421
Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 310 bits (795), Expect = 1e-84
Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)
Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+
Sbjct: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672
Query: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V
Sbjct: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 731
Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP
Sbjct: 732 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 790
Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA
Sbjct: 791 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 850
Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F
Sbjct: 851 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 910
Query: 439 DEEFTAQMITITPP 452
DEEFT + T++PP
Sbjct: 911 DEEFTGEAPTLSPP 924
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 310 bits (795), Expect = 1e-84
Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)
Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+
Sbjct: 607 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 666
Query: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V
Sbjct: 667 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 725
Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP
Sbjct: 726 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 784
Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA
Sbjct: 785 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 844
Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F
Sbjct: 845 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 904
Query: 439 DEEFTAQMITITPP 452
DEEFT + T++PP
Sbjct: 905 DEEFTGEAPTLSPP 918
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
FD +FT++ + +TP D+D SE F F Y
Sbjct: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
FD +FT++ + +TP D+D SE F F Y
Sbjct: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 369 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
FD +FT++ + +TP D+D SE F F Y
Sbjct: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 580
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 297 bits (760), Expect = 2e-80
Identities = 160/350 (45%), Positives = 217/350 (62%), Gaps = 12/350 (3%)
Query: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
E E S+ + ++ FE L++LGKG +GKV V++ TG+ +AMK+LKK +IV
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
Query: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
AKD AHT E +L+ +HPF+ L Y+FQT +L ++EY +GGELF L RE +F
Sbjct: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
ED A FY AEI AL +LH +K ++YRDLK EN+ML+ GH+K+TDFGLCKE I DG
Sbjct: 192 EDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVT 250
Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + IL ++
Sbjct: 251 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 310
Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
P L EA+ LL LLK++ RLG G DA E+ H FF I W+ + +K+ PPFK
Sbjct: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFK 370
Query: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
P + SE D FD +FT Q TP D D +S + F F+Y A
Sbjct: 371 PLLQSEEDVSQFDSKFTRQ----TPVDSPDDSTLSESANQV-FLGFTYVA 415
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 296 bits (757), Expect = 4e-80
Identities = 144/317 (45%), Positives = 207/317 (65%), Gaps = 8/317 (2%)
Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
R+ +++F +L +LGKG+FGKV+L + + + YA+KILKK+VIV D+V TL E RVL
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
Query: 204 ------NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257
R FLT L +FQT DRL FVMEY GG+L +H+ + F E A FY AEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
L +LH++ ++YRDLKL+N+MLD +GHIKITDFG+CKE + G T +TFCGTP+Y+A
Sbjct: 465 AIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIA 523
Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377
PE++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++L EA
Sbjct: 524 PEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAV 583
Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
++ G L K P +RLG G + I H FF I W+ + ++ PPF+P+ +
Sbjct: 584 AICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN- 642
Query: 438 FDEEFTAQMITITPPDQ 454
FD+ FT +TPPD+
Sbjct: 643 FDKFFTRAAPALTPPDR 659
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 291 bits (745), Expect = 9e-79
Identities = 152/349 (43%), Positives = 220/349 (63%), Gaps = 12/349 (3%)
Query: 133 EMEVSLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD 190
E E++ +P ++ + +++ K+LGKG+FGKV L + K T +++A+K LKK+V++ D
Sbjct: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
Query: 191 EVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249
+V T+ E RVL + HPFLT + +FQT + L FVMEY NGG+L +H+ F R
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309
A FY AEI+ L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE + A TF
Sbjct: 481 ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 539
Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369
CGTP+Y+APE+L Y +VDWW GV++YEM+ G+ PF+ QD E+LF I M+ +P
Sbjct: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599
Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429
R L EAK LL L ++P++RLG +I QH F I W+ + K++ PPF+P+V
Sbjct: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKV 655
Query: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478
S D FD+EF + ++ D+ ++S + F FS+ G
Sbjct: 656 KSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 700
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 291 bits (745), Expect = 9e-79
Identities = 156/350 (44%), Positives = 217/350 (62%), Gaps = 12/350 (3%)
Query: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
E E S+ R+ + FE L++LGKG +GKV V++ G+ YAMK+L+K IV
Sbjct: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
Query: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
AKD AHT E +L++ +HPF+ L Y+FQT +L ++E +GGELF HL RE +F
Sbjct: 109 NAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
ED A FY AEI AL +LHS+ ++YRDLK EN+ML GHIK+TDFGLCKE I +GA
Sbjct: 168 EDTACFYLAEITLALGHLHSQ-GIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVT 226
Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + I+ ++
Sbjct: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286
Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
P L P+A+ L+ LK++P QR+GGG DA ++ +H FF + W + ++ PPF+
Sbjct: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFR 346
Query: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
P + SE D FD FT Q TP D D +S + F F+Y A
Sbjct: 347 PCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQA-FLGFTYVA 391
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,544,307
Number of Sequences: 37866
Number of extensions: 911874
Number of successful extensions: 4865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 657
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 2430
Number of HSP's gapped (non-prelim): 1064
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.