Search of human proteins with 61966709

Search of human proteins with 61966709

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
         (228 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61966709 leucine rich repeat containing 67 [Homo sapiens]          455   e-128
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    77   2e-14
gi|157674358 leucine rich repeat containing 50 [Homo sapiens]          76   3e-14
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    75   4e-14
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           69   3e-12
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    62   5e-10
gi|31377705 centrosomal protein 97kDa [Homo sapiens]                   59   4e-09
gi|40217817 slit and trk like 1 protein [Homo sapiens]                 57   1e-08
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  57   1e-08
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof...    57   1e-08
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof...    57   1e-08
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]             54   8e-08
gi|149773484 leucine rich repeat and fibronectin type III domain...    54   1e-07
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s...    54   1e-07
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s...    54   1e-07
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s...    54   1e-07
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s...    54   1e-07
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]             52   3e-07
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]             52   3e-07
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]             52   3e-07
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...    52   4e-07
gi|157743290 leucine rich repeat containing 30 [Homo sapiens]          52   5e-07
gi|15529980 leucine rich repeat containing 46 [Homo sapiens]           51   9e-07
gi|164607156 axonemal dynein light chain 1 [Homo sapiens]              50   1e-06
gi|31621309 leucine rich repeat containing 6 [Homo sapiens]            50   1e-06
gi|4503743 flightless I homolog [Homo sapiens]                         48   6e-06
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]            47   1e-05
gi|4507531 toll-like receptor 3 [Homo sapiens]                         46   2e-05
gi|239754500 PREDICTED: Leucine-rich repeat-containing protein E...    45   5e-05
gi|239749060 PREDICTED: Leucine-rich repeat-containing protein E...    45   5e-05

>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
          Length = 228

 Score =  455 bits (1170), Expect = e-128
 Identities = 228/228 (100%), Positives = 228/228 (100%)

Query: 1   MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDN 60
           MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDN
Sbjct: 1   MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDN 60

Query: 61  CISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRE 120
           CISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRE
Sbjct: 61  CISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRE 120

Query: 121 LHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQL 180
           LHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQL
Sbjct: 121 LHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQL 180

Query: 181 LHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLGTYLY 228
           LHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLGTYLY
Sbjct: 181 LHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLGTYLY 228


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 63/197 (31%), Positives = 97/197 (49%), Gaps = 12/197 (6%)

Query: 27  LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
           LKK+  +N     I  IE+LS    L +L L  N I  I N++  TNL  L+L  N I+ 
Sbjct: 166 LKKLFLVN---NKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITK 222

Query: 87  IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK 146
           ++NL +L  L  L +  N +  IEGL+ L  LREL++ +  + + E L            
Sbjct: 223 LQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGL--------ENNN 274

Query: 147 SLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
            L +L+I++N I  I ++  L  L +    DN L    DL+  L     L  + L  NP+
Sbjct: 275 KLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLD-ELKGARSLETVYLERNPL 333

Query: 207 CLKPKYRDRLILVSKSL 223
              P+YR +++L   S+
Sbjct: 334 QKDPQYRRKVMLALPSV 350



 Score = 70.9 bits (172), Expect = 9e-13
 Identities = 54/167 (32%), Positives = 84/167 (50%), Gaps = 8/167 (4%)

Query: 25  QCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCI 84
           + LKK+  +      I  IE+L   ++L  L LYDN I +I NL   T L  L +  N +
Sbjct: 95  EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLL 154

Query: 85  SCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSL 144
             IE +  L +L+KL+L  N I+ IE L  L +L+ L + + R+   E +     TL +L
Sbjct: 155 RNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI----DTLTNL 210

Query: 145 AKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLN 191
                 L +  N I  + +L+ L NL  L    N+L  ++ L+ L+N
Sbjct: 211 ES----LFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN 253



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 56/186 (30%), Positives = 90/186 (48%), Gaps = 14/186 (7%)

Query: 33  INFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRS 92
           ++ +   I  IE   + K +  L L  N I  I NL    +L  L L +N I  IENL +
Sbjct: 81  VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140

Query: 93  LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILN 152
           L +LE L +  N +  IEG++ L  L++L + N ++   E L      LH L     +L 
Sbjct: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL----SNLHQLQ----MLE 192

Query: 153 ISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLM------KLWKIDLNGNPV 206
           + +N I  I +++ L NL  L    N++  +++L+ L N  +      +L KI+   N V
Sbjct: 193 LGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLV 252

Query: 207 CLKPKY 212
            L+  Y
Sbjct: 253 NLRELY 258



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 11/164 (6%)

Query: 43  IEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLG 102
           +E ++L ++   + L    I +I        +  L L+ N I CIENL  L+ L +L L 
Sbjct: 69  METINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLY 128

Query: 103 GNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDIT 162
            N I  IE LE L EL  L +    L   E +  D  T     K L ++N   + I++++
Sbjct: 129 DNQIKKIENLEALTELEILDISFNLLRNIEGV--DKLT---RLKKLFLVNNKISKIENLS 183

Query: 163 DLELLENL----NQLIAVDN--QLLHVKDLEFLLNKLMKLWKID 200
           +L  L+ L    N++ A++N   L +++ L    NK+ KL  +D
Sbjct: 184 NLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD 227


>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
          Length = 725

 Score = 75.9 bits (185), Expect = 3e-14
 Identities = 66/206 (32%), Positives = 93/206 (45%), Gaps = 32/206 (15%)

Query: 23  ISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNN 82
           I+  L    +++F  K  D IE+L     L  L+L  N I +I NL   T L  L+LQ N
Sbjct: 104 ITPALNDTLYLHF--KGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMN 161

Query: 83  CISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLH 142
            +  IENL  L+KL+ L L  NYI  IE L  L  L  L + +  L   E +      L 
Sbjct: 162 LLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLR 221

Query: 143 SLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLN 202
                LC+L++S+N + D   L +LE++  L                         ++L 
Sbjct: 222 -----LCVLDLSHNKLSDPEILSILESMPDLRV-----------------------LNLM 253

Query: 203 GNPVCLK-PKYRDRLILVSKSLGTYL 227
           GNPV  + P YR  + +  K L TYL
Sbjct: 254 GNPVIRQIPNYRRTVTVRLKHL-TYL 278


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 75.5 bits (184), Expect = 4e-14
 Identities = 61/179 (34%), Positives = 86/179 (48%), Gaps = 22/179 (12%)

Query: 35  FSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLK 94
           F DK + +I +LSL   L  + L+ N IS+I  +++  NL HL L +N IS IE L +L 
Sbjct: 28  FMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLT 87

Query: 95  KLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNIS 154
           KL  L L  N I  +EGLE L  L  L+V    +     L+     LH +   L  +++ 
Sbjct: 88  KLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLI----PLHGIKHKLRYIDLH 143

Query: 155 NNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYR 213
           +N ID I  L               L  +  L FL N +++    D + NPVC  P YR
Sbjct: 144 SNRIDSIHHL---------------LQCMVGLHFLTNLILEK---DGDDNPVCRLPGYR 184


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 59/185 (31%), Positives = 86/185 (46%), Gaps = 9/185 (4%)

Query: 33  INFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRS 92
           +NF    I  I+++S  + L  L LYDN I +I+ L+    L  L L  N I  I NL +
Sbjct: 117 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLEN 176

Query: 93  LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILN 152
           LK L+ L L GN I  IE +  L ELR L+       L    L     L+ L  SL  LN
Sbjct: 177 LKSLDVLDLHGNQITKIENINHLCELRVLN-------LARNFLSHVDNLNGL-DSLTELN 228

Query: 153 ISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKY 212
           + +N I  + D++ L  L  L    N +     +  L +    L  I  +GNP+  +  Y
Sbjct: 229 LRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS-SSLSDITFDGNPIAQESWY 287

Query: 213 RDRLI 217
           +  ++
Sbjct: 288 KHTVL 292



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 43/145 (29%), Positives = 72/145 (49%), Gaps = 11/145 (7%)

Query: 27  LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
           L+K+  ++  D  I+ I  LS  + L VL L  N I +I+NL    +L  L L  N I+ 
Sbjct: 133 LQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 192

Query: 87  IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQR---------LPLGEKLLFD 137
           IEN+  L +L  L L  N+++ ++ L GL  L EL++ + +         LP  + L   
Sbjct: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLS 252

Query: 138 PRTLHSLAKSLCILNISNNNIDDIT 162
              + S     C+ +  ++++ DIT
Sbjct: 253 FNNISSFDSVSCLAD--SSSLSDIT 275



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 54/180 (30%), Positives = 82/180 (45%), Gaps = 17/180 (9%)

Query: 32  HINFSDKNIDAIEDLSLCKNLSVLY-----LYDNCISQITNLNYATNLTHLYLQNNCISC 86
           HIN    ++ +   L       +LY     L    ++    +N   +L  L  Q+N I+ 
Sbjct: 67  HINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITR 126

Query: 87  IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK 146
           I+N+ +L+KL  L L  N    IE + GL  LR L V    L LG+  +     L +L K
Sbjct: 127 IQNISNLQKLISLDLYDNQ---IEEISGLSTLRCLRV----LLLGKNRIKKISNLENL-K 178

Query: 147 SLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
           SL +L++  N I  I ++  L  L  L    N L HV +    LN L  L +++L  N +
Sbjct: 179 SLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDN----LNGLDSLTELNLRHNQI 234


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 9/143 (6%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           K +   +FS   I  I DLS    L+ L L  N I +I+ L    NL HL L NN I+ I
Sbjct: 193 KNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTI 252

Query: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147
             L  L  ++ L L  N I +I GLE L  L+ L + + ++   + L       H L   
Sbjct: 253 NGLNKL-PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGL-----ENHDL--- 303

Query: 148 LCILNISNNNIDDITDLELLENL 170
           L ++N+ +N I ++ ++E ++NL
Sbjct: 304 LEVINLEDNKIAELREIEYIKNL 326



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 56/201 (27%), Positives = 91/201 (45%), Gaps = 12/201 (5%)

Query: 14  NLKPRKEETIS--QCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYA 71
           +L   K E +S   C+  +  +N S  N+    +    KNL       N IS+I +L+  
Sbjct: 155 DLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAY 214

Query: 72  TNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLG 131
             LT L L  N I  I  L     L  L L  N I  I GL  L  ++ L + N ++ + 
Sbjct: 215 HALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIEMI 273

Query: 132 EKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLN 191
             L           K+L  L++S+N I  +  LE  + L  +   DN++  ++++E++ N
Sbjct: 274 TGL--------EDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKN 325

Query: 192 KLMKLWKIDLNGNPVCLKPKY 212
            L  L  ++L  NP+  K +Y
Sbjct: 326 -LPILRVLNLLENPIQEKSEY 345


>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
          Length = 865

 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 17/159 (10%)

Query: 32  HINFSDKN-IDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENL 90
           H    DKN I  +E+L  CK L  L + +N + ++  +   T L  L L +N I C+E L
Sbjct: 39  HTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGL 98

Query: 91  RSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRL----PLGEKLLFDPRTLHS--- 143
           + L  LE L L GN +  +E +     L+ L + +  +     L + +      LH    
Sbjct: 99  KELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNII 158

Query: 144 ---------LAKSLCILNISNNNIDDITDLELLENLNQL 173
                    L +SL IL+++ N I D+ ++  L +L +L
Sbjct: 159 TSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTEL 197



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 40/147 (27%), Positives = 67/147 (45%), Gaps = 9/147 (6%)

Query: 33  INFSDKNIDAIEDLSLCK-NLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLR 91
           +N+S + +  +     C+ ++  L L  N I ++ NL     L  L + NN +  +  + 
Sbjct: 18  VNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVA 77

Query: 92  SLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCIL 151
            L  L  L L  N I  +EGL+ L  L  L++    L   E++        +   +L  L
Sbjct: 78  KLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI--------NSCTALQHL 129

Query: 152 NISNNNIDDITDLELLENLNQLIAVDN 178
           ++S+NNI  I DL  L +L  L+   N
Sbjct: 130 DLSDNNISQIGDLSKLVSLKTLLLHGN 156



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 15/156 (9%)

Query: 67  NLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQ 126
           NL    ++  L L  N I  +ENL   K+L +L +  N +  + G+  L  LR L++ + 
Sbjct: 31  NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90

Query: 127 RLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDL 186
            +   E L      +H     L  LN++ NN+  +  +     L  L   DN +  + D 
Sbjct: 91  SIGCVEGL---KELVH-----LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGD- 141

Query: 187 EFLLNKLMKLWKIDLNGNPVC---LKPKYRDRLILV 219
              L+KL+ L  + L+GN +    + P Y  R + +
Sbjct: 142 ---LSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAI 174



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 8/97 (8%)

Query: 13  SNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCIS--QITNLNY 70
           +NLK    E I+ C   + H++ SD NI  I DLS   +L  L L+ N I+  ++     
Sbjct: 112 NNLKAM--EQINSCTA-LQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYL 168

Query: 71  ATNLTHLYLQNNCI---SCIENLRSLKKLEKLYLGGN 104
             +L  L L  N I   + I  L SL +LE+L +  N
Sbjct: 169 PRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNN 205


>gi|40217817 slit and trk like 1 protein [Homo sapiens]
          Length = 696

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 54/181 (29%), Positives = 96/181 (53%), Gaps = 15/181 (8%)

Query: 33  INFSDKNIDAIEDLS-LCKNLSVLYLYDNCISQITNLNYAT--NLTHLYLQNNCISCIEN 89
           +N +++N+ ++ DL     N+  L+L DN I  I   ++    NL  L L NN I+ +EN
Sbjct: 357 MNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVEN 416

Query: 90  --LRSLKKLEKLYLGGNYIAVI--EGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLA 145
              ++L  L  LY+  NY+  +  E   GL  L  L+VE   + L       P T +++ 
Sbjct: 417 NTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQL-----ILPGTFNAMP 471

Query: 146 KSLCILNISNNNIDDI-TDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGN 204
           K L IL ++NN +  +  D+    +L++L   +N  +++  +  +L++L  + +IDL+GN
Sbjct: 472 K-LRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLP-VAGVLDQLTSIIQIDLHGN 529

Query: 205 P 205
           P
Sbjct: 530 P 530


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 56/173 (32%), Positives = 79/173 (45%), Gaps = 34/173 (19%)

Query: 38  KNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLE 97
           K    IE+L  C  L VL L  N I +I  L+    L  L L  N IS IE + ++  L+
Sbjct: 113 KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQ 172

Query: 98  KLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNN 157
           KL L GN                  +E+  + LG+KL           KSL +LN+  N 
Sbjct: 173 KLNLAGN-----------------EIEHIPVWLGKKL-----------KSLRVLNLKGNK 204

Query: 158 I---DDITDLELLENLNQLIAVDNQLLHVKD-LEFLLNKLMKLWKIDLNGNPV 206
           I    DI+ L+ L++L  LI V+N ++ +   L+F +  L  L    L G PV
Sbjct: 205 ISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSL--ESLEGQPV 255


>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
            [Homo sapiens]
          Length = 1722

 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 49/178 (27%), Positives = 80/178 (44%), Gaps = 6/178 (3%)

Query: 46   LSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNY 105
            L   KNL  L L  N +     L     + +L   +N ++ +E + +   L+ L L GNY
Sbjct: 965  LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024

Query: 106  IAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLE 165
            ++ +  LE L  LRELH+++  +   E   F    L  L      + IS N++  I  L 
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSISTVE--AFSSYWLPLLQN----ITISQNSLTKIVPLF 1078

Query: 166  LLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSL 223
               +L +L    N L  +K      +    L ++ L GNP+  +  +RD L+ V  +L
Sbjct: 1079 HFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPAL 1136



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 35/194 (18%)

Query: 27  LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
           L+++T + F D     +  L+ C NL  L L    ++ + +L+    L ++  Q N I  
Sbjct: 795 LQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEA 854

Query: 87  IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLP-------LGEKLLFDPR 139
           IE   +L+ L  + L  N +  + GL+G   ++ L +   ++        L EKL+ +  
Sbjct: 855 IE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAG 913

Query: 140 TLHSLAKSLCILNIS--------------------NNNIDDITD-------LELLENLNQ 172
             H L  S   L+++                    N++ + +         LE L+NL Q
Sbjct: 914 FCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQ 973

Query: 173 LIAVDNQLLHVKDL 186
           LI   NQL++ K L
Sbjct: 974 LILDHNQLINTKGL 987



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 43/166 (25%), Positives = 66/166 (39%), Gaps = 22/166 (13%)

Query: 30   ITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIEN 89
            I +++ S  ++  +E +  C  L +L L  N +S++ +L     L  L+L +N IS +E 
Sbjct: 993  IVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEA 1052

Query: 90   LRS--LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLP------------------ 129
              S  L  L+ + +  N +  I  L     L +L V +  L                   
Sbjct: 1053 FSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHEL 1112

Query: 130  --LGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL 173
               G  LL +     SL K L  L I N NI +       E  NQL
Sbjct: 1113 SLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQL 1158


>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
            [Homo sapiens]
          Length = 1336

 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 49/178 (27%), Positives = 80/178 (44%), Gaps = 6/178 (3%)

Query: 46   LSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNY 105
            L   KNL  L L  N +     L     + +L   +N ++ +E + +   L+ L L GNY
Sbjct: 965  LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024

Query: 106  IAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLE 165
            ++ +  LE L  LRELH+++  +   E   F    L  L      + IS N++  I  L 
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSISTVE--AFSSYWLPLLQN----ITISQNSLTKIVPLF 1078

Query: 166  LLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSL 223
               +L +L    N L  +K      +    L ++ L GNP+  +  +RD L+ V  +L
Sbjct: 1079 HFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPAL 1136



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 35/194 (18%)

Query: 27  LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
           L+++T + F D     +  L+ C NL  L L    ++ + +L+    L ++  Q N I  
Sbjct: 795 LQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEA 854

Query: 87  IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLP-------LGEKLLFDPR 139
           IE   +L+ L  + L  N +  + GL+G   ++ L +   ++        L EKL+ +  
Sbjct: 855 IE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAG 913

Query: 140 TLHSLAKSLCILNIS--------------------NNNIDDITD-------LELLENLNQ 172
             H L  S   L+++                    N++ + +         LE L+NL Q
Sbjct: 914 FCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQ 973

Query: 173 LIAVDNQLLHVKDL 186
           LI   NQL++ K L
Sbjct: 974 LILDHNQLINTKGL 987



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 43/166 (25%), Positives = 66/166 (39%), Gaps = 22/166 (13%)

Query: 30   ITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIEN 89
            I +++ S  ++  +E +  C  L +L L  N +S++ +L     L  L+L +N IS +E 
Sbjct: 993  IVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEA 1052

Query: 90   LRS--LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLP------------------ 129
              S  L  L+ + +  N +  I  L     L +L V +  L                   
Sbjct: 1053 FSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHEL 1112

Query: 130  --LGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL 173
               G  LL +     SL K L  L I N NI +       E  NQL
Sbjct: 1113 SLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQL 1158


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 60/208 (28%), Positives = 99/208 (47%), Gaps = 18/208 (8%)

Query: 8   LIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCK--NLSVLYLYDNCISQI 65
           L+ +++N+    +E   Q L  +T ++FS  N   I+++ L     L+ L+L +N I+++
Sbjct: 77  LLLQSNNIAKTVDEL--QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEM 134

Query: 66  TN--LNYATNLTHLYLQNNCISCIEN--LRSLKKLEKLYLGGNYIAVIEG--LEGLGELR 119
           T+  L   +NL  LY+ +N IS I       LK L +L+L  N + VI+    +    L 
Sbjct: 135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLE 194

Query: 120 ELHV-ENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDN 178
            L + EN  + + +        L SL  +   L     N      L  L++L  L   DN
Sbjct: 195 ILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNA-----LVGLDSLESLSFYDN 249

Query: 179 QLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
           +L+ V  L   L K+  L  +DLN NP+
Sbjct: 250 KLVKVPQLA--LQKVPNLKFLDLNKNPI 275


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 17/178 (9%)

Query: 55  LYLYDNCISQITNLNYA--TNLTHLYLQNNCISCIEN--LRSLKKLEKLYLGGNYIAVIE 110
           L L DN I+ +   ++A  T+L HL L  N I  +       L+ L  L+L  N +A + 
Sbjct: 70  LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVR 129

Query: 111 G--LEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDI--TDLEL 166
           G  L GLG LR L + N ++   E   FD     +   ++  L++S NN++ +    +  
Sbjct: 130 GDQLRGLGNLRHLILGNNQIRRVESAAFD-----AFLSTVEDLDLSYNNLEALPWEAVGQ 184

Query: 167 LENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLG 224
           + NLN L    N + H+ +  F+  +L KL ++D+  N +   P   D L L S+  G
Sbjct: 185 MVNLNTLTLDHNLIDHIAEGTFV--QLHKLVRLDMTSNRLHKLPP--DGLFLRSQGTG 238


>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 5/139 (3%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           K +  +    +NI  I++L   +NL  L L +N I +I  L    +L  L L  N I  I
Sbjct: 43  KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102

Query: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147
           E L +L  LE L L  N I+ I+ L+ L +L+ L + N R+     +++  R      K 
Sbjct: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKC 157

Query: 148 LCILNISNNNIDDITDLEL 166
           L  L++S N I +  D ++
Sbjct: 158 LRTLSLSRNPISEAEDYKM 176



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 48  LCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIA 107
           L K++  L L    I +I NL    NL  L L NN I  IE L +L  L  L L  N I 
Sbjct: 41  LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIE 100

Query: 108 VIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL 167
            IEGL+ L  L +L + N R+   +       +L +L K L +L++ NN ID++ ++  L
Sbjct: 101 TIEGLDTLVNLEDLSLFNNRISKID-------SLDALVK-LQVLSLGNNRIDNMMNIIYL 152

Query: 168 ENLNQL 173
                L
Sbjct: 153 RRFKCL 158


>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 5/139 (3%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           K +  +    +NI  I++L   +NL  L L +N I +I  L    +L  L L  N I  I
Sbjct: 43  KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102

Query: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147
           E L +L  LE L L  N I+ I+ L+ L +L+ L + N R+     +++  R      K 
Sbjct: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKC 157

Query: 148 LCILNISNNNIDDITDLEL 166
           L  L++S N I +  D ++
Sbjct: 158 LRTLSLSRNPISEAEDYKM 176



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 48  LCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIA 107
           L K++  L L    I +I NL    NL  L L NN I  IE L +L  L  L L  N I 
Sbjct: 41  LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIE 100

Query: 108 VIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL 167
            IEGL+ L  L +L + N R+   +       +L +L K L +L++ NN ID++ ++  L
Sbjct: 101 TIEGLDTLVNLEDLSLFNNRISKID-------SLDALVK-LQVLSLGNNRIDNMMNIIYL 152

Query: 168 ENLNQL 173
                L
Sbjct: 153 RRFKCL 158


>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 5/139 (3%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           K +  +    +NI  I++L   +NL  L L +N I +I  L    +L  L L  N I  I
Sbjct: 43  KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102

Query: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147
           E L +L  LE L L  N I+ I+ L+ L +L+ L + N R+     +++  R      K 
Sbjct: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKC 157

Query: 148 LCILNISNNNIDDITDLEL 166
           L  L++S N I +  D ++
Sbjct: 158 LRTLSLSRNPISEAEDYKM 176



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 48  LCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIA 107
           L K++  L L    I +I NL    NL  L L NN I  IE L +L  L  L L  N I 
Sbjct: 41  LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIE 100

Query: 108 VIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL 167
            IEGL+ L  L +L + N R+   +       +L +L K L +L++ NN ID++ ++  L
Sbjct: 101 TIEGLDTLVNLEDLSLFNNRISKID-------SLDALVK-LQVLSLGNNRIDNMMNIIYL 152

Query: 168 ENLNQL 173
                L
Sbjct: 153 RRFKCL 158


>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 5/139 (3%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           K +  +    +NI  I++L   +NL  L L +N I +I  L    +L  L L  N I  I
Sbjct: 43  KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102

Query: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147
           E L +L  LE L L  N I+ I+ L+ L +L+ L + N R+     +++  R      K 
Sbjct: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKC 157

Query: 148 LCILNISNNNIDDITDLEL 166
           L  L++S N I +  D ++
Sbjct: 158 LRTLSLSRNPISEAEDYKM 176



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 48  LCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIA 107
           L K++  L L    I +I NL    NL  L L NN I  IE L +L  L  L L  N I 
Sbjct: 41  LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIE 100

Query: 108 VIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL 167
            IEGL+ L  L +L + N R+   +       +L +L K L +L++ NN ID++ ++  L
Sbjct: 101 TIEGLDTLVNLEDLSLFNNRISKID-------SLDALVK-LQVLSLGNNRIDNMMNIIYL 152

Query: 168 ENLNQL 173
                L
Sbjct: 153 RRFKCL 158


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 28/182 (15%)

Query: 51  NLSVLYLYDNCISQITNLNY--ATNLTHLYLQNNCISCIEN--LRSLKKLEKLYLGGNYI 106
           NL+ L L  N +S +TN+N      L  +YL+ N ++ +    L  L  L++LY+  N +
Sbjct: 93  NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLL 152

Query: 107 AVIE--GLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK------------------ 146
           + I      GL  L  LH+ + RL +     FD      +                    
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 147 SLCILNISNNNIDDITDLEL--LENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGN 204
           +L  L I+  N+ +I D  L  LENL  +   DN+L+ V  +   L K++ L  +DLN N
Sbjct: 213 NLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV--ALQKVVNLKFLDLNKN 270

Query: 205 PV 206
           P+
Sbjct: 271 PI 272


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 28/182 (15%)

Query: 51  NLSVLYLYDNCISQITNLNY--ATNLTHLYLQNNCISCIEN--LRSLKKLEKLYLGGNYI 106
           NL+ L L  N +S +TN+N      L  +YL+ N ++ +    L  L  L++LY+  N +
Sbjct: 93  NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLL 152

Query: 107 AVIE--GLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK------------------ 146
           + I      GL  L  LH+ + RL +     FD      +                    
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 147 SLCILNISNNNIDDITDLEL--LENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGN 204
           +L  L I+  N+ +I D  L  LENL  +   DN+L+ V  +   L K++ L  +DLN N
Sbjct: 213 NLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV--ALQKVVNLKFLDLNKN 270

Query: 205 PV 206
           P+
Sbjct: 271 PI 272


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 28/182 (15%)

Query: 51  NLSVLYLYDNCISQITNLNY--ATNLTHLYLQNNCISCIEN--LRSLKKLEKLYLGGNYI 106
           NL+ L L  N +S +TN+N      L  +YL+ N ++ +    L  L  L++LY+  N +
Sbjct: 93  NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLL 152

Query: 107 AVIE--GLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK------------------ 146
           + I      GL  L  LH+ + RL +     FD      +                    
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 147 SLCILNISNNNIDDITDLEL--LENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGN 204
           +L  L I+  N+ +I D  L  LENL  +   DN+L+ V  +   L K++ L  +DLN N
Sbjct: 213 NLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHV--ALQKVVNLKFLDLNKN 270

Query: 205 PV 206
           P+
Sbjct: 271 PI 272


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score = 52.0 bits (123), Expect = 4e-07
 Identities = 60/196 (30%), Positives = 96/196 (48%), Gaps = 20/196 (10%)

Query: 25  QCLKKITHINFSDKNIDAIEDLSLC--KNLSVLYLYDNCISQI-TNLNYATNLTHLYLQN 81
           +CL  +  ++ S  ++     L +C  KNL VL L DN I Q+ + L   + L  L L  
Sbjct: 300 RCLVNLRFLDLSQNHLHHCP-LQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTG 358

Query: 82  N-CISCIENLRSLKKLEKLYLGGN----YIAVIEGLEGLGELRELHVENQRLPLGEKLLF 136
           N  +S  E + SL  LEKLY+G +       V E +  L  L+EL++EN  L       +
Sbjct: 359 NEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLE------Y 412

Query: 137 DPRTLHSLAKSLCILNISNNNIDDITD-LELLENLNQLIAVDNQLLHVKDLEFLLNKLMK 195
            P +L S+  +L +L+  +N +  + D +   + L +L   DN L H+ +    L+ L+ 
Sbjct: 413 LPVSLGSM-PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPE---NLDSLVN 468

Query: 196 LWKIDLNGNPVCLKPK 211
           L  + L  NP+   PK
Sbjct: 469 LKVLTLMDNPMEEPPK 484


>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
          Length = 301

 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 54/168 (32%), Positives = 86/168 (51%), Gaps = 14/168 (8%)

Query: 4   LTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCIS 63
           + L+L        PR E ++ QCLK +  +N +    +   +LSLC+ L VL L  NC+S
Sbjct: 97  VVLNLCGNRLKSLPR-EVSLLQCLK-VLFVNMNCLT-EVPAELSLCRKLEVLSLSHNCLS 153

Query: 64  QI-TNLNYATNLTHLYLQNNCISCIEN-LRSLKKLEKLYLGGNYIA-VIEGLEGLGELRE 120
           Q+       + L  L L NN  + I   + SLK+L  L++G N +  + E ++ L  L+ 
Sbjct: 154 QLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQI 213

Query: 121 LHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDI-TDLELL 167
              E      G  +   PR+L  L  SL +LN++NN+I  + ++L LL
Sbjct: 214 FIAE------GNNIHSFPRSL-CLVTSLELLNLNNNDIQTLPSELHLL 254


>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
          Length = 321

 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 55/160 (34%), Positives = 71/160 (44%), Gaps = 19/160 (11%)

Query: 30  ITHINFSDKNIDAIEDLSLCKN-------LSVLYLYDNCISQITNLNYATNLTHLYLQNN 82
           IT    + +N+   ED  L +        L  + L    I+ I NL    NL  LYLQ N
Sbjct: 17  ITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGN 76

Query: 83  CISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLH 142
            I  IENL  +  L  L L GN I  +E L  L  L       Q L L E L+ +   L 
Sbjct: 77  KIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCL-------QFLDLSENLI-ETLKLD 128

Query: 143 SLAKSLCILNISNN---NIDDITDLELLENLNQLIAVDNQ 179
              +SL ILN+S N   N D   +L + E L  L+ +D Q
Sbjct: 129 EFPQSLLILNLSGNSCTNQDGYREL-VTEALPLLLDLDGQ 167



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 30/90 (33%), Positives = 42/90 (46%)

Query: 21  ETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQ 80
           E +   L ++  +    + I  I +L   +NL  LYL  N I QI NL    +L  L L 
Sbjct: 37  EKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLA 96

Query: 81  NNCISCIENLRSLKKLEKLYLGGNYIAVIE 110
            N I  +ENL  L  L+ L L  N I  ++
Sbjct: 97  GNQIRQVENLLDLPCLQFLDLSENLIETLK 126


>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
          Length = 190

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 52/149 (34%), Positives = 69/149 (46%), Gaps = 19/149 (12%)

Query: 67  NLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGE-LRELHVEN 125
           +L+   N   L L  NCI  I NL  LK L  L LG N I  + GLE +G+ L EL +  
Sbjct: 43  SLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISY 102

Query: 126 QRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDD---ITDLELLENLNQLIAVDNQLLH 182
             +   EKL    + +H + K L IL +SNN + D      L  L  L  L+ V N L  
Sbjct: 103 NFI---EKL----KGIH-IMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEE 154

Query: 183 VKD-----LEFLLNKLMKLWKIDLNGNPV 206
                   +E    ++ KL K+D  G PV
Sbjct: 155 KHSAENNWIEEATKRVPKLKKLD--GTPV 181



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 28/81 (34%), Positives = 45/81 (55%), Gaps = 1/81 (1%)

Query: 46  LSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSL-KKLEKLYLGGN 104
           LS+  N   L L  NCI +I NLN   NL  L L  N I  +  L ++   LE+L++  N
Sbjct: 44  LSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYN 103

Query: 105 YIAVIEGLEGLGELRELHVEN 125
           +I  ++G+  + +L+ L++ N
Sbjct: 104 FIEKLKGIHIMKKLKILYMSN 124


>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 8/113 (7%)

Query: 4   LTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSL-CKNLSVLYLYDNCI 62
           +T DLI RN+       E     +  +  ++   + I+ +E +   C++L +LYL +N I
Sbjct: 4   ITEDLIRRNA-------EHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLI 56

Query: 63  SQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGL 115
            +I N++    L +L L  N I  IENL   ++L KL L  N+I  +  ++ L
Sbjct: 57  GKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNL 109



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 32/72 (44%), Positives = 43/72 (59%), Gaps = 1/72 (1%)

Query: 51  NLSVLYLYDNCISQITNLN-YATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVI 109
           +L  L L+   I ++ +++ +  +L  LYLQNN I  IEN+  LKKLE L L  N I  I
Sbjct: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81

Query: 110 EGLEGLGELREL 121
           E LEG  EL +L
Sbjct: 82  ENLEGCEELAKL 93



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 4/76 (5%)

Query: 19  KEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCI---SQITNLNYATNLT 75
           K E +S+ LKK+ ++N +  NI+ IE+L  C+ L+ L L  N I   S I NL +  +L 
Sbjct: 58  KIENVSK-LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLK 116

Query: 76  HLYLQNNCISCIENLR 91
            L+L  N  +  ++ R
Sbjct: 117 ELFLMGNPCASFDHYR 132



 Score = 31.2 bits (69), Expect = 0.77
 Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 10/123 (8%)

Query: 96  LEKLYLGGNYIAVIEGLEG-LGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNIS 154
           LE+L L    I  +E ++    +L+ L+++N  +   E +        S  K L  LN++
Sbjct: 23  LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENV--------SKLKKLEYLNLA 74

Query: 155 NNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRD 214
            NNI+ I +LE  E L +L    N +  +  ++ L + +  L ++ L GNP      YR+
Sbjct: 75  LNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNI-HLKELFLMGNPCASFDHYRE 133

Query: 215 RLI 217
            ++
Sbjct: 134 FVV 136


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 47/161 (29%), Positives = 80/161 (49%), Gaps = 23/161 (14%)

Query: 67  NLNYATNLTHLYLQNNCISCI-ENLRSLKKLEKLYLGGNYIAVIEG-LEGLGELREL--- 121
           N+   T+L  L L    +  + E L +L+KLE L +  N +  + G L  L  LR +   
Sbjct: 28  NVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVAR 87

Query: 122 --HVENQRLP-----LGEKLLFD---------PRTLHSLAKSLCILNISNNNIDDITDLE 165
              ++N  +P     L +  + D         PR L + AK++ +LN+S+N+ID I + +
Sbjct: 88  ANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPN-Q 145

Query: 166 LLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
           L  NL  L+ +D     ++ L   + +L+ L  + LNGNP+
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL 186



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 30/190 (15%)

Query: 45  DLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYL---QNNCISCIENLRSLKKLEKLYL 101
           +L   KN+ VL L  N I  I N  +      LYL   +N   S    +R L  L+ L L
Sbjct: 122 ELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVL 181

Query: 102 GGNYI--AVIEGLEGLGELRELHVEN-----QRLPLGEKLLFD--------------PRT 140
            GN +  A +  L  +  L+ LH+ +       LP   + L +              P  
Sbjct: 182 NGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPEC 241

Query: 141 LHSLAKSLCILNISNNNIDDIT-DLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLW-- 197
           L++L  SL  LN+S+N I +++  ++   ++  L    NQL  +      L+KL KL+  
Sbjct: 242 LYTL-PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300

Query: 198 --KIDLNGNP 205
             K+D +G P
Sbjct: 301 SNKLDFDGLP 310



 Score = 28.1 bits (61), Expect = 6.5
 Identities = 35/149 (23%), Positives = 59/149 (39%), Gaps = 20/149 (13%)

Query: 23  ISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNN 82
           + +CL  +  +   + + + I +LSLC +  V          +  LN +        +N 
Sbjct: 238 VPECLYTLPSLRRLNLSSNQITELSLCIDQWV---------HVETLNLS--------RNQ 280

Query: 83  CISCIENLRSLKKLEKLYLGGN---YIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPR 139
             S    +  L KL+KLYL  N   +  +  G+  L  L E    N  L L  + L    
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340

Query: 140 TLHSLAKSLCILNISNNNIDDITDLELLE 168
            L  L  +   L      I  +T++E+L+
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLD 369


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 55/190 (28%), Positives = 96/190 (50%), Gaps = 12/190 (6%)

Query: 17  PRKEETISQCLKKITHINFSDKNIDAI-EDLSLCKNLSVLYLYDNCISQIT-NLNYATNL 74
           P   E+IS C K +   +FS   +  + E     +NL+ L + D  +  +  N+    NL
Sbjct: 95  PEIPESISFC-KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNL 153

Query: 75  THLYLQNNCISCI-ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEK 133
             L L+ N ++ + ++L  L++LE+L LG N I  +   E +G L  LH+++  L  G +
Sbjct: 154 ASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP--ESIGAL--LHLKDLWLD-GNQ 208

Query: 134 LLFDPRTLHSLAKSLCILNISNNNIDDI-TDLELLENLNQLIAVDNQLLHVKDLEFLLNK 192
           L   P+ + +L   LC L++S N ++ +  ++  L +L  L+   N L  + D    L K
Sbjct: 209 LSELPQEIGNLKNLLC-LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKK 267

Query: 193 LMKLWKIDLN 202
           L  + K+D N
Sbjct: 268 L-SILKVDQN 276


>gi|4507531 toll-like receptor 3 [Homo sapiens]
          Length = 904

 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 63/225 (28%), Positives = 98/225 (43%), Gaps = 48/225 (21%)

Query: 17  PRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTH 76
           P+ ++   Q LK + H+N  D +I  I+       +++ YL  +  +  T+L   TN T 
Sbjct: 344 PKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYL--SLSNSFTSLRTLTNETF 401

Query: 77  ----------LYLQNNCISCIEN--LRSLKKLEKLYLGGNYIAV-IEGLE--GLGELREL 121
                     L L  N IS IE+     L  LE L LG N I   + G E  GL  + E+
Sbjct: 402 VSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEI 461

Query: 122 HVENQR-----------LPLGEKLLFDPRTLHSLAKS---------LCILNISNNNIDDI 161
           ++   +           +P  ++L+     L ++  S         L IL++SNNNI +I
Sbjct: 462 YLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANI 521

Query: 162 TDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
            D ++LE L +L  +D Q           N L +LWK    G P+
Sbjct: 522 ND-DMLEGLEKLEILDLQ----------HNNLARLWKHANPGGPI 555



 Score = 35.0 bits (79), Expect = 0.053
 Identities = 39/143 (27%), Positives = 68/143 (47%), Gaps = 14/143 (9%)

Query: 29  KITHINFSDKNIDAIEDLSLCKNL---SVLYLYDNCISQITNLNYA--TNLTHLYLQNNC 83
           ++T ++     I  +E   LC+ L    VL L  N +SQ+++  +A  TNLT L+L +N 
Sbjct: 76  QLTSLDVGFNTISKLEP-ELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNS 134

Query: 84  ISCIENLRSLKKLEKLYLGGNYIAVIEGLEG----LGELRELHVENQRLPLGEKLLFDPR 139
           I  I+N   +K+   + L  ++  +     G    L  L+EL + N ++   +    D  
Sbjct: 135 IQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIF 194

Query: 140 TLHSLAKSLCILNISNNNIDDIT 162
              SL K    L +S+N I + +
Sbjct: 195 ANSSLKK----LELSSNQIKEFS 213


>gi|239754500 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 34/90 (37%), Positives = 45/90 (50%), Gaps = 4/90 (4%)

Query: 36  SDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKK 95
           S K +  + DLS  K L  L+L+ N +  IT L     LT LYL NN I  IE L  L  
Sbjct: 102 SKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPS 161

Query: 96  LEKLYLGGNYI----AVIEGLEGLGELREL 121
           L  L L  N +    A ++ L+G+  L+ L
Sbjct: 162 LHILLLHHNELTNIDATVKELKGMLNLKIL 191



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 6/93 (6%)

Query: 42  AIED-LSLC-----KNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKK 95
           A+ED L +C      ++  L+L    ++++ +L+    L +L+L +N +  I  L     
Sbjct: 80  AVEDQLKICGHRRDADVFELFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYC 139

Query: 96  LEKLYLGGNYIAVIEGLEGLGELRELHVENQRL 128
           L +LYL  N I  IEGL  L  L  L + +  L
Sbjct: 140 LTELYLNNNAIFEIEGLHYLPSLHILLLHHNEL 172



 Score = 32.0 bits (71), Expect = 0.45
 Identities = 25/77 (32%), Positives = 44/77 (57%), Gaps = 12/77 (15%)

Query: 144 LAKSLCI--LNISNNNIDDITDLELLENLNQLIAVDNQLLH----VKDLEFLLN-KLMKL 196
           L ++ C+  L ++NN I +I  L  L +L+ L+   N+L +    VK+L+ +LN K++ L
Sbjct: 134 LTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDATVKELKGMLNLKILSL 193

Query: 197 WKIDLNGNPVCLKPKYR 213
           ++     NP+C    YR
Sbjct: 194 YQ-----NPLCQYNLYR 205



 Score = 28.5 bits (62), Expect = 5.0
 Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 1/73 (1%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           KK+ ++      +  I  L+    L+ LYL +N I +I  L+Y  +L  L L +N ++ I
Sbjct: 116 KKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNI 175

Query: 88  E-NLRSLKKLEKL 99
           +  ++ LK +  L
Sbjct: 176 DATVKELKGMLNL 188


>gi|239749060 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 34/90 (37%), Positives = 45/90 (50%), Gaps = 4/90 (4%)

Query: 36  SDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKK 95
           S K +  + DLS  K L  L+L+ N +  IT L     LT LYL NN I  IE L  L  
Sbjct: 102 SKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPS 161

Query: 96  LEKLYLGGNYI----AVIEGLEGLGELREL 121
           L  L L  N +    A ++ L+G+  L+ L
Sbjct: 162 LHILLLHHNELTNIDATVKELKGMLNLKIL 191



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 6/93 (6%)

Query: 42  AIED-LSLC-----KNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKK 95
           A+ED L +C      ++  L+L    ++++ +L+    L +L+L +N +  I  L     
Sbjct: 80  AVEDQLKICGHRRDADVFELFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYC 139

Query: 96  LEKLYLGGNYIAVIEGLEGLGELRELHVENQRL 128
           L +LYL  N I  IEGL  L  L  L + +  L
Sbjct: 140 LTELYLNNNAIFEIEGLHYLPSLHILLLHHNEL 172



 Score = 32.0 bits (71), Expect = 0.45
 Identities = 25/77 (32%), Positives = 44/77 (57%), Gaps = 12/77 (15%)

Query: 144 LAKSLCI--LNISNNNIDDITDLELLENLNQLIAVDNQLLH----VKDLEFLLN-KLMKL 196
           L ++ C+  L ++NN I +I  L  L +L+ L+   N+L +    VK+L+ +LN K++ L
Sbjct: 134 LTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDATVKELKGMLNLKILSL 193

Query: 197 WKIDLNGNPVCLKPKYR 213
           ++     NP+C    YR
Sbjct: 194 YQ-----NPLCQYNLYR 205



 Score = 28.5 bits (62), Expect = 5.0
 Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 1/73 (1%)

Query: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87
           KK+ ++      +  I  L+    L+ LYL +N I +I  L+Y  +L  L L +N ++ I
Sbjct: 116 KKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNI 175

Query: 88  E-NLRSLKKLEKL 99
           +  ++ LK +  L
Sbjct: 176 DATVKELKGMLNL 188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.140    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,925,858
Number of Sequences: 37866
Number of extensions: 324143
Number of successful extensions: 1322
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 1031
Number of HSP's gapped (non-prelim): 306
length of query: 228
length of database: 18,247,518
effective HSP length: 99
effective length of query: 129
effective length of database: 14,498,784
effective search space: 1870343136
effective search space used: 1870343136
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.