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Search of human proteins with 134948605
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
(2039 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 4047 0.0
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 4034 0.0
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 536 e-151
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 133 2e-30
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 111 8e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 110 1e-23
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 109 2e-23
gi|87299628 biorientation of chromosomes in cell division 1-like... 104 1e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 103 2e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 103 2e-21
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 103 2e-21
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 103 2e-21
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 103 2e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 102 3e-21
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 102 4e-21
gi|148746195 trichohyalin [Homo sapiens] 102 4e-21
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 101 7e-21
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 100 1e-20
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 100 2e-20
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 100 2e-20
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 99 3e-20
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 99 3e-20
gi|221219020 NYD-SP11 protein [Homo sapiens] 99 6e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 99 6e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 99 6e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 98 7e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 98 7e-20
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 4047 bits (10496), Expect = 0.0
Identities = 2039/2039 (100%), Positives = 2039/2039 (100%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 61 KLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQM 120
KLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQM
Sbjct: 61 KLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQM 120
Query: 121 TARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKE 180
TARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKE
Sbjct: 121 TARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKE 180
Query: 181 LISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGH 240
LISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGH
Sbjct: 181 LISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGH 240
Query: 241 RDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVN 300
RDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVN
Sbjct: 241 RDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVN 300
Query: 301 PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK
Sbjct: 301 PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
Query: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC
Sbjct: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
Query: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL
Sbjct: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
Query: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT
Sbjct: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
Query: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK
Sbjct: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
Query: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK
Sbjct: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
Query: 661 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK
Sbjct: 661 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
Query: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE
Sbjct: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
Query: 781 KEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSEC 840
KEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSEC
Sbjct: 781 KEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSEC 840
Query: 841 VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA 900
VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA
Sbjct: 841 VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA 900
Query: 901 ESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK 960
ESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK
Sbjct: 901 ESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK 960
Query: 961 SSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLL 1020
SSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLL
Sbjct: 961 SSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLL 1020
Query: 1021 KLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK 1080
KLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK
Sbjct: 1021 KLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK 1080
Query: 1081 QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNR 1140
QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNR
Sbjct: 1081 QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNR 1140
Query: 1141 SQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTP 1200
SQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTP
Sbjct: 1141 SQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTP 1200
Query: 1201 RPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLST 1260
RPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLST
Sbjct: 1201 RPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLST 1260
Query: 1261 SHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTS 1320
SHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTS
Sbjct: 1261 SHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTS 1320
Query: 1321 PSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPV 1380
PSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPV
Sbjct: 1321 PSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPV 1380
Query: 1381 HLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENA 1440
HLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENA
Sbjct: 1381 HLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENA 1440
Query: 1441 DFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQ 1500
DFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQ
Sbjct: 1441 DFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQ 1500
Query: 1501 QKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLP 1560
QKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLP
Sbjct: 1501 QKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLP 1560
Query: 1561 VLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLT 1620
VLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLT
Sbjct: 1561 VLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLT 1620
Query: 1621 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1680
HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST
Sbjct: 1621 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1680
Query: 1681 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1740
QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE
Sbjct: 1681 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1740
Query: 1741 SSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLD 1800
SSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLD
Sbjct: 1741 SSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLD 1800
Query: 1801 EIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSK 1860
EIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSK
Sbjct: 1801 EIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSK 1860
Query: 1861 ICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTL 1920
ICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTL
Sbjct: 1861 ICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTL 1920
Query: 1921 ANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTC 1980
ANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTC
Sbjct: 1921 ANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTC 1980
Query: 1981 LLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI 2039
LLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI
Sbjct: 1981 LLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI 2039
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 4034 bits (10462), Expect = 0.0
Identities = 2039/2062 (98%), Positives = 2039/2062 (98%), Gaps = 23/2062 (1%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 61 KLPFTISPSRNEERDSDT-----------------------EKEGPEKKKTKKEAGNKKS 97
KLPFTISPSRNEERDSDT EKEGPEKKKTKKEAGNKKS
Sbjct: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
Query: 98 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 157
TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK
Sbjct: 121 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
Query: 158 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 217
RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA
Sbjct: 181 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
Query: 218 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 277
GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL
Sbjct: 241 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
Query: 278 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 337
KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE
Sbjct: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
Query: 338 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 397
YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR
Sbjct: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
Query: 398 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 457
VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN
Sbjct: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
Query: 458 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 517
KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST
Sbjct: 481 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
Query: 518 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 577
GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC
Sbjct: 541 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
Query: 578 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 637
KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER
Sbjct: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
Query: 638 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 697
EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL
Sbjct: 661 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
Query: 698 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 757
EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
Query: 758 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 817
KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT
Sbjct: 781 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
Query: 818 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 877
FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR
Sbjct: 841 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
Query: 878 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 937
EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK
Sbjct: 901 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
Query: 938 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 997
KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK
Sbjct: 961 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
Query: 998 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1057
DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF
Sbjct: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
Query: 1058 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1117
ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR
Sbjct: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
Query: 1118 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1177
SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS
Sbjct: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
Query: 1178 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1237
SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE
Sbjct: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
Query: 1238 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1297
RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
Sbjct: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
Query: 1298 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1357
KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK
Sbjct: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
Query: 1358 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1417
YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN
Sbjct: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
Query: 1418 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1477
IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS
Sbjct: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
Query: 1478 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1537
DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF
Sbjct: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
Query: 1538 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1597
VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE
Sbjct: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
Query: 1598 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1657
NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL
Sbjct: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
Query: 1658 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1717
SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA
Sbjct: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
Query: 1718 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1777
NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP
Sbjct: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
Query: 1778 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1837
SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA
Sbjct: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
Query: 1838 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1897
PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE
Sbjct: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
Query: 1898 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1957
REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR
Sbjct: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
Query: 1958 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2017
FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI
Sbjct: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
Query: 2018 YEIQEFYVPLVDVNDDFELTPI 2039
YEIQEFYVPLVDVNDDFELTPI
Sbjct: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 536 bits (1380), Expect = e-151
Identities = 466/1414 (32%), Positives = 697/1414 (49%), Gaps = 202/1414 (14%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPK G K Q E S+MVEK G+K KDK+ S +KTPK+ER D KE++E++S KR
Sbjct: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKV-SLTKTPKLERGDGGKEVRERAS-KR 58
Query: 61 KLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPV------SILFGYPLSERKQM 114
KLPFT + E++DSDTEK+GPE+K+ KKE +K+ + I GYPLSER+Q+
Sbjct: 59 KLPFTAG-ANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQV 117
Query: 115 ALLMQMTARD--NSP-DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAI 171
ALLMQMTA + NSP D+TP HPSQ+T QK TP+S+S+ KDKVNKRNERGET LH AAI
Sbjct: 118 ALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAI 177
Query: 172 RGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 231
RGD +++KELIS GA+VNVKDFAGWT LHEACN GYYDVAK L+AAGA+VNT+GLDDDTP
Sbjct: 178 RGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTP 237
Query: 232 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT 291
LHD+A++GH +VKLLLR+GGNP Q+N+ GE P+ VA + + LL + + +ES T
Sbjct: 238 LHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESST 297
Query: 292 DS---EEAQSVNP-SSVD-ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDE 346
+S E+A S P SSVD N DSE EK L ++K P K P DEYEF +DD++
Sbjct: 298 ESSEEEDAPSFAPSSSVDGNNTDSEFEK-GLKHKAKNPEPQKATAP-VKDEYEFDEDDEQ 355
Query: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 406
+ +DD+H+L+K+ RKE + + + K E Y K+ +K S + S T
Sbjct: 356 DRVPPVDDKHLLKKDYRKETKSNSFIS--IPKMEVKSYTKNNTIAPKKASHRILSDTSDE 413
Query: 407 DEEAL---QNKKISTSC-SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN 462
++ ++ +K+ S +++P + + K + K+K KVK+K K + K +E
Sbjct: 414 EDASVTVGTGEKLRLSAHTILPGSKTREPSNAK------QQKEKNKVKKKRKKETKGREV 467
Query: 463 QELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK 522
+ K+ + ++ + + +G D + G + S D SL +S +
Sbjct: 468 RFGKRSDKFC-SSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSL-FSSLSASSTSS 525
Query: 523 HSCGLSEKQSTPLKQEHT--------KTCLSPGSSEMSLQPDLVRYDNT-ESEFLPESSS 573
H ++KQ+ +HT KT SP SE+S D R T ES++ E SS
Sbjct: 526 HGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSS 585
Query: 574 VKSCKH-KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKL 632
V+S K +++ +H+K L E SP +++ + K+DKEGK +KKHK
Sbjct: 586 VESLKPVRKRQEHRKRASL-----------SEKKSPFLSSAEGAVPKLDKEGKVVKKHKT 634
Query: 633 KHKEREKEKHK----KEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFK-SDETEDLF 687
KHK + KEK + +E++ + Y+ +DS ++ +++ + + EN K D F
Sbjct: 635 KHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHF 694
Query: 688 LNMEHES-LTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKE------SEKSFR 740
E S + LE+K L K+ K K K+ + R+F+EE+D+ K EKS +
Sbjct: 695 KKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPK 754
Query: 741 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 800
EEK++ KEER+ D+ S+ L E +I EK EK KE KEK +
Sbjct: 755 EEKLRLYKEERKKKSKDRPSKLEKKN----------DLKEDKISKEK-EKIFKEDKEKLK 803
Query: 801 KRSQIKEKDI--EKMERKTFEKEKKIKHE-HKSEKDK--LDLSECVDKIKEKDKLYSHHT 855
K +E E + F + + K ++D+ DLS+ K +D S T
Sbjct: 804 KEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVT 863
Query: 856 E--------------KCHKEG--EKSKNTAAIKKTDDRE-----KSREKMDRKHDKEKPE 894
+ + KE E+ +++ A +K D RE K R+ +D+ +K K +
Sbjct: 864 DYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQ 923
Query: 895 KERHLAESKEKHLMEKKNKQSDNSEYSKSEK-------------GKNKEKDRE------- 934
E+H +S +L EK K+ +++E + K K +E RE
Sbjct: 924 TEKH--KSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGC 981
Query: 935 ----LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 990
DK + K +E++K D + + KP KEK+ D+
Sbjct: 982 ESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKS 1041
Query: 991 GKEKDKKDKDIDR-YKE----RDKH-----KDKIQINSLLKLKSEADKPKP-----KSSP 1035
EK +KDK+ D+ +KE ++KH KDK + SL + K + +K P S
Sbjct: 1042 ILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSE 1101
Query: 1036 ASKDTRPKEKRLVNDDLMQTSFE-----------RMLSLKDL-------EIEQW------ 1071
D + KEK D+ E +M DL E E+
Sbjct: 1102 KKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYAS 1161
Query: 1072 --HKK-----HKEKIKQKE-KERLRNRNCLELKIKDKEKTKHTPTESKNKELT---RSKS 1120
H+K H E+ K KE ++R ++R + KEK E K+KE T + +
Sbjct: 1162 DRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK 1221
Query: 1121 SEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRS 1180
+ T++K+ K + +++ K SD S+ K S+ +
Sbjct: 1222 DRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKE-----HSKERKSSRSADA 1276
Query: 1181 VSMISVASSEDSCHTTVTTPRPPVEYDSD----FMLESSESQMSFSQSP----FLSIAKS 1232
+ E++ H EY D SS+S Q P FL ++ +
Sbjct: 1277 EKSLLEKLEEEALH----------EYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFT 1326
Query: 1233 PALHERELDSLADLPERIKPPYANRLSTSHLRSS 1266
+ + A LPE++K +R S+S + S
Sbjct: 1327 EPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
Score = 452 bits (1162), Expect = e-126
Identities = 231/337 (68%), Positives = 275/337 (81%), Gaps = 10/337 (2%)
Query: 1707 QIPQRMTRNKANTMANQSKQILASCTLLSEKD---SESSSPRGRIRLTEDDDPQIHHPRK 1763
+IPQRMTRN+A +ANQSKQ SEK+ + + R + R +EDDD Q HPRK
Sbjct: 2331 EIPQRMTRNRAQMLANQSKQGPPP----SEKECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386
Query: 1764 RKVSRVPQPVQ--VSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRK 1821
R+ R Q +Q ++ S Q +E QQ+LAAIVD++KLD I+PY S+RANPYFEYL IRK
Sbjct: 2387 RRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRK 2446
Query: 1822 KIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFR 1881
KIEEKRK+LC + PQAPQ Y EYVT+ GSYLLDG PLSK+ IP I PPPSL++PLKELFR
Sbjct: 2447 KIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFR 2506
Query: 1882 QQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNV 1941
QQE VR KLRLQHSIEREKLIVS EQE+LRVH RAART+ANQ +PFSACT+LLD+EVYN+
Sbjct: 2507 QQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNM 2566
Query: 1942 PLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQ 2001
PL+SQ D++K SVRDRFNARQF+SWLQDVDDK+D++KTCLLMRQQHEAAALNAVQR+EWQ
Sbjct: 2567 PLESQGDENK-SVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQ 2625
Query: 2002 LKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTP 2038
LK+QELDPA +KS+ + E+ FYVP+VDVNDDF L P
Sbjct: 2626 LKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLP 2662
Score = 181 bits (460), Expect = 5e-45
Identities = 258/1123 (22%), Positives = 454/1123 (40%), Gaps = 184/1123 (16%)
Query: 266 DVAETEELELLLKREVPLSDDDESYTDSEEAQSVN-PSSVDENIDSET-----EKDSLIC 319
D + E E LK + P + Y + + +S + PS +++ D + EK+ +
Sbjct: 737 DRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK 796
Query: 320 ESKQILPSKTPL--PSALDEY----EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 373
E K+ L + SA DEY +F +++D + + L +QR + +
Sbjct: 797 EDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFS--------LSDDQRDRWFSDLSDS 848
Query: 374 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS------------ 421
K E ++ + K V E+ E++ + ++ S +
Sbjct: 849 SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908
Query: 422 ----VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN--QELKQEKEGKENT 475
+ + QT+K V G +K K +R+ +++++ + K+ ++G+
Sbjct: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968
Query: 476 RITNLTV--NTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 533
+ G + K + +G+F K P + H + K K K+ T
Sbjct: 969 EEAHREELKECGCESGFKDKSDGDFGKGLEPWER-----HHPAREKEKKDGPDKERKEKT 1023
Query: 534 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 593
++ K+ S + + ++ + EF K K K K H KD +
Sbjct: 1024 KPERYKEKS-----SDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK- 1077
Query: 594 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 653
K K E P + D + KK DK+GK + E E + G K
Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKM 1137
Query: 654 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 713
A +L R+ + + +E + + + H + ++ + +K+ +
Sbjct: 1138 ---GEASDLPRT---------DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRR 1185
Query: 714 KEKHVS------KERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGM 767
K++ + KE+ F++ ++K KES + +++ K +R ++ + +D +
Sbjct: 1186 KDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK------DRASVDSTQDKKNKQKLP 1239
Query: 768 SAIEESIGLHLVEKEIDIEKQEKHIKE-SKEKPEKRSQIKEKDI-EKMERKTFEKEKKIK 825
E+ H E + + +EK KE SKE+ RS EK + EK+E + + ++
Sbjct: 1240 EKAEKK---HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296
Query: 826 HEHKSE----------------------------KDKLDLSECV-DKIKEKDK-LYSHHT 855
++ SE DK S C+ +K+KEK++ +S +
Sbjct: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356
Query: 856 EKCHKEGEKSKNTAAIKKT---DDREKSREKMDRKHDKE-------------KPEKERHL 899
K + E++K A KK D +E K +++K+ K + E L
Sbjct: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
Query: 900 AESKEKHLMEKKNKQSDNSEYSKS----------------EKGKNKEKDREL--DKKEKS 941
++ E EKK+K E SK ++ K +EK RE D+KE+
Sbjct: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERH 1476
Query: 942 RDKESINITNS------KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
RD+ + + +H ++E+K + D + P LK+K++DE + D K K+
Sbjct: 1477 RDRHADGLLRHHRDELLRHHRDEQKPATRD----KDSPPRVLKDKSRDEGPRLGDAKLKE 1532
Query: 996 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1055
K ++ K +K+ + DK P P KD RP+EK L + DLM T
Sbjct: 1533 KFKDGAEKEK-----------GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMT 1581
Query: 1056 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1115
SFERMLS KDLEIE+ HK+HKE++KQ EK R R+ + K KEK K K
Sbjct: 1582 SFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD-----PKLKEKAKPADDGRKKGLD 1636
Query: 1116 TRSKSSEVTDAYTKEKQPKD------AVSNR---SQSVDTKNVMTLGKSSFVSDNSLNRS 1166
+K D K+K+ K+ A N+ + D+K+ + V L S
Sbjct: 1637 IPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEV----LPAS 1692
Query: 1167 PRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPF 1226
PR + +P S++S S E+ HT TP + +D + + ++SQ S
Sbjct: 1693 PRPDQSRPTGVPTPTSVLSCPSYEEVMHTP-RTPSCSADDYADLVFDCADSQHSTPVPTA 1751
Query: 1227 LSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVE 1269
+ A SP+ +R + + L E A LST+ RS SV+
Sbjct: 1752 PTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVD 1794
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 133 bits (334), Expect = 2e-30
Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 1/153 (0%)
Query: 126 SPDSTPNHPSQTTPAQ-KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISL 184
SP + P+ S ++ + +PS+ + KRN RGET LH+A+I+GD+ V+ L+
Sbjct: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450
Query: 185 GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIV 244
G++ NVKD AGWTPLHEACN G+ V ++L+ A VNT G +D+PLHD+A +GH DIV
Sbjct: 451 GSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIV 510
Query: 245 KLLLRHGGNPFQANKHGERPVDVAETEELELLL 277
KLLL +G + N G RPVD + E ++ LL
Sbjct: 511 KLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 124 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 183
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 184 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 243
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 244 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 304 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 363
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 364 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 421
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 422 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 481
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 482 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 535
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 536 KQEHTKTCLS 545
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 141 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 193 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 306
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 124 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 183
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 184 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 243
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 244 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 304 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 363
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 364 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 421
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 422 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 481
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 482 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 535
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 536 KQEHTKTCLS 545
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 141 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 193 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 306
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 124 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 183
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 184 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 243
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 244 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 304 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 363
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 364 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 421
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 422 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 481
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 482 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 535
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 536 KQEHTKTCLS 545
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 141 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 193 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 306
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 111 bits (277), Expect = 8e-24
Identities = 116/591 (19%), Positives = 273/591 (46%), Gaps = 52/591 (8%)
Query: 580 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTL---------KKMDKEGKTLKKH 630
K+ ++ Q+ L EKS ++ ++ E + L ++M ++ + L++
Sbjct: 225 KKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 284
Query: 631 KLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNM 690
+ K +++E++ ++E +++ K ++ +++ R + RE KE +
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE--------------L 330
Query: 691 EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE 750
+ L ++ +L + + + +EK +E +E+ +K+ ++ E+ + +EK +E+
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
Query: 751 R----ENIPTDKDSEFTSLGMSAIEESIGLHLVEK---EIDIEKQEKHIKESKEKPEKRS 803
+ E ++D E+ VEK E +++QEK ++ +EK ++
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 804 QIKEKD---------IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 854
+I+E++ + + E K ++E+ + + + E + L E +K+ E++K+
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM-QEQ 509
Query: 855 TEKCHKEGEKSKNTAAI----KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEK 910
EK ++ EK ++ + KK +EK RE+ D+ ++E+ +++ ++ MEK
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 911 KNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 970
K ++ + + + EK + +E+ RE +KK + ++ QEEK + Q
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 971 HEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS----EA 1026
EK +EK ++ K + +EK + + + KE+ +K+Q ++ + E
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 1027 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK--KHKEKIKQKEK 1084
+K + K+ K T +EK + ++ M+ ++M +++ EQ K + +EK++++E+
Sbjct: 690 EKMEKKTQEQEKKTWDQEK-MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 1085 ERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1135
E + + + + + P E K K K E + +E++ +D
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLP-EQKEKLWEHEKMQEQEKIWEQEEKMRD 798
Score = 100 bits (250), Expect = 1e-20
Identities = 105/523 (20%), Positives = 253/523 (48%), Gaps = 56/523 (10%)
Query: 618 KKMDKEGKTLKKHKLKHKEREK-----EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREF 672
++M ++ + L++ + + +E+EK EK ++E + ++++ KT+D +++Q + E
Sbjct: 397 ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ-----EEER 451
Query: 673 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI--KDDKSTKEKHVSKERNFKEERDK 730
+E K E E+ E EK K E+N+ +++K +++ + +++ E++K
Sbjct: 452 IREREKKMREEEETMREQE------EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 731 IKKESEKSF-REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 789
++++ EK + +EEKI+D +E M E+ + ++ + +QE
Sbjct: 506 MQEQEEKIWEQEEKIRDQEE-----------------MWGQEKKMW-----RQEKMREQE 543
Query: 790 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 849
+ E +EK + Q E+ME+KT E+EKK + + +++ + E K++E+++
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 850 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 909
+ EK ++ EK + K + EK +E+ ++ ++E+ E+ +++ L E
Sbjct: 604 MMREQEEKMQEQEEKMQEQEE-KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 910 KKNKQSDNSEYSKSEK-GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 968
+K K ++ + + EK + +EK E +K EK ++ + + ++EE+ S+ + K
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE--SMREREK 720
Query: 969 AQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1028
E+ ++E ++E ++ + K ++++++ ++ ++ + ++K+ L + E
Sbjct: 721 KMREEEEMMRE--QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 1029 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERML----SLKDLEIEQWHKKHK-----EKI 1079
K K +EK ++ M+ E+M ++ E + W ++ K EK+
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 1080 KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1122
+E++ +E K++ +E+ E + + + E
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881
Score = 93.2 bits (230), Expect = 2e-18
Identities = 134/674 (19%), Positives = 285/674 (42%), Gaps = 99/674 (14%)
Query: 335 LDEYEFKDDDDEEINKMIDDRHILRKEQR--KENEPEAEKTHLFAKQEKAFYPKSFKSKK 392
L E E K + EE KM LR++++ +E E E + +QE+ + K +
Sbjct: 302 LREQEGKMREQEE--KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 393 QKPSRVLYSSTESSDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVK 450
Q+ EE L Q K++ M+ ++E + + + + K +
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQM--------REQEQKMRDQEERMWEQDERLREKEE 411
Query: 451 RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR---KSFSPKDD 507
R + + ++ +++++EK+ +E + T D EK +EE R K +++
Sbjct: 412 RMREQEKMWEQVEKMREEKKMQEQEKKTR-------DQEEKMQEEERIREREKKMREEEE 464
Query: 508 TSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEF 567
T K K + E++ +Q+ + +Q + E +
Sbjct: 465 TMRE----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 568 LPESS---SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 624
+ K +EK + Q+D E EK ++D++ + K ++E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK----MRDQEQKMWDQEERMEKKTQEQEK 576
Query: 625 KTL-KKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 683
KT ++ K++ +ER +E+ KK E E+ + ++ +E + ++ E E K E
Sbjct: 577 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 684 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 743
E+ E + E+K ++ + + K +H + E++K++++ EK + +EK
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ-----EQEKMQEQEEKIWEQEK 691
Query: 744 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PE 800
++ +E+E D++ EES+ E+E + ++E+ ++E +EK E
Sbjct: 692 MEKKTQEQEKKTWDQEK-------MREEESMR----EREKKMREEEEMMREQEEKMQEQE 740
Query: 801 KRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHK 860
++ Q +E+++ + E K +E+E+K+ + + + K L E +K++E++K++ EK
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH-EKMQEQEKIWEQE-EKMRD 798
Query: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 920
+ EK + EKM + +K + ++E+ + ++ E+K + +
Sbjct: 799 QEEKMRG------------QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
Query: 921 SKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK 980
+ EK + K + +E EK R++E EK +EK
Sbjct: 847 GQEEKMEEKMQGQE----EKMREQE--------------------------EKMRGQEEK 876
Query: 981 TKDEPLKTPDGKEK 994
+++ K +EK
Sbjct: 877 MREQEEKMRGQEEK 890
Score = 90.5 bits (223), Expect = 2e-17
Identities = 96/477 (20%), Positives = 216/477 (45%), Gaps = 76/477 (15%)
Query: 641 KHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEH 692
+HKK +E K +D+ EL R+ + E K+N E ++ LN++
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 693 ESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERE 752
LE+ L ++ + + +E+ +E +E+ KI+K+ EK +R+E+
Sbjct: 251 LKRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--------- 300
Query: 753 NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEK 812
L E+E + +QE E + EKR + +EK++ +
Sbjct: 301 ------------------------RLREQEGKMREQE----EKMWRQEKRLREQEKELRE 332
Query: 813 MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIK 872
E++ E+++ + E + ++ + + E +K++E+++ E+ E EK K
Sbjct: 333 QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW-EQEKQMREQEQK 391
Query: 873 KTDDREKSREKMDRKHDKEKPEKERH-LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 931
D E+ E+ +R +KE+ +E+ + E EK EKK ++ + + EK + +E+
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 932 DRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL 986
RE +KK E R++E +++ E+++ + ++ L +EK +++
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 987 KTPDGKEKDK------------------KDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1028
K + +EK + ++++ +++ +K +D+ Q K+ + ++
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQEER 566
Query: 1029 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1085
+ K+ K T +E+++ ++ M+ ++M +++ EQ K +++ K +E+E
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Score = 81.6 bits (200), Expect = 7e-15
Identities = 123/598 (20%), Positives = 244/598 (40%), Gaps = 68/598 (11%)
Query: 256 QANKHGERPVDVAETEEL-----ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 310
Q K E+ + E EE E L ++E + + ++ D EE + E +
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 311 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ--RKENEP 368
E++ + + +++ K + E E K D EE KM ++ I +E+ R+E E
Sbjct: 413 MREQEKMWEQVEKMREEKK-----MQEQEKKTRDQEE--KMQEEERIREREKKMREEEET 465
Query: 369 EAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSN 428
E+ KQE+ + + K +Q+ ++ Q +KI I +
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
Query: 429 SDMQTKKEYVVSGEHKQKGKV---KRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG 485
Q KK + +Q+ ++ + K+++Q + +QE + EK+ +E + T
Sbjct: 526 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT------- 578
Query: 486 LDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLS 545
D EK REE R+ K + + +Q ++++ K
Sbjct: 579 WDQEEKMREEERMRER----------------EKKMREEEEMMREQEEKMQEQEEK---- 618
Query: 546 PGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDED 605
M Q + + E E + K + +EK Q++ E K K +
Sbjct: 619 -----MQEQEEKM----WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 606 HSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 665
H E K ++E K ++ K++ K +E+EK ++EK + ++S +E ++
Sbjct: 670 HEKMQEQE----KMQEQEEKIWEQEKMEKKTQEQEKKT----WDQEKMREEESMREREKK 721
Query: 666 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKK--SKLEKNIKDDKSTKEKHVSKERN 723
+ + E +E K E E+ E E E+K + EK + + ++K E
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 724 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 783
+E++KI ++ EK +E+ +EE+ +K E+ G +E
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG-----QEE 836
Query: 784 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 841
+ QE+ + +EK E++ Q +E+ + + E K +E+K++ + + + + + CV
Sbjct: 837 KMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCV 894
Score = 53.1 bits (126), Expect = 3e-06
Identities = 64/332 (19%), Positives = 153/332 (46%), Gaps = 51/332 (15%)
Query: 786 EKQEKHIKE-SKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHKSEKDKLDLSECVD 842
+K +++I+E +KE+ ++ I E++++K E ++K+ +SEK ++ L+
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLN---- 247
Query: 843 KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAES 902
+KE + + + ++ ++ + +K+ ++ +K ++ER
Sbjct: 248 -VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER----- 301
Query: 903 KEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSS 962
L E++ K + E ++ + +E+++EL ++EK + K ++E+++
Sbjct: 302 ----LREQEGKMREQEEKMWRQEKRLREQEKELREQEK-------ELREQKELREQEEQM 350
Query: 963 IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKL 1022
+ Q EK +EK +++ ++ + R +ER ++K K+
Sbjct: 351 -----QEQEEKMWEQEEKMREQ-------------EEKMWRQEERLWEQEKQMREQEQKM 392
Query: 1023 KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQK 1082
+ + ++ + + R KE+R+ + M E+M K ++ EQ K ++ K +
Sbjct: 393 RDQEERMWEQ----DERLREKEERMREQEKMWEQVEKMREEKKMQ-EQEKKTRDQEEKMQ 447
Query: 1083 EKERLRNRNCLELKIKDKEKTKHTPTESKNKE 1114
E+ER+R R E K++++E+T E K+
Sbjct: 448 EEERIRER---EKKMREEEETMREQEEKMQKQ 476
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 110 bits (276), Expect = 1e-23
Identities = 105/488 (21%), Positives = 245/488 (50%), Gaps = 48/488 (9%)
Query: 626 TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 685
T+ +LK K + ++ + +E EK + + + KEL+R +E + + +++
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQL--NVKELKRKLERAKLLLPQQQLQAEADH- 269
Query: 686 LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEK-SFRE 741
L E +S++ + ++++E+N + ++ +EK +E +E +KI+++ EK +E
Sbjct: 270 --LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 742 EKIKDLKEE---RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 798
EKI++ +E+ +E + +K+ + E+ + +E E+ EK+EK I+E +EK
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE-EMMWEKEEK-IRELEEK 385
Query: 799 PEKRSQIKEKDIEKMER-KTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEK 857
++ +I+E++ ++ E K E+EK+ + E K + + + E +KI+E++K EK
Sbjct: 386 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 858 CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 917
H++ EK RE+ R+ +E +E + E +E + +K K +
Sbjct: 446 IHEQ----------------EKIREEEKRQEQEEMWRQEEKIREQEE--IWRQKEKMHEQ 487
Query: 918 SEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSL 977
+ K E+ +++++ D++EK R++E + I+E+++ + Q EK
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI-----REQEEKIREQ 542
Query: 978 KEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPAS 1037
+E +++ K + +EK ++ + + R +E+ + +++ K++ + +K + +
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE-------KIREQKEKIREQEE--- 592
Query: 1038 KDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI 1097
K +EK +++MQ E+M ++ EQ K +++ K + +E + L+
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 1098 KDKEKTKH 1105
++++ +H
Sbjct: 653 QEEKMQEH 660
Score = 105 bits (263), Expect = 3e-22
Identities = 97/435 (22%), Positives = 212/435 (48%), Gaps = 27/435 (6%)
Query: 580 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 630
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 631 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 689
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 690 MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 749
E E+K + ++ + +K K + + E E+ +KI++ EK +EKI++ +E
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRL--EEMMWEKEEKIRELEEKMHEQEKIREQEE 397
Query: 750 ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 806
+R E I + + M EE I E+E I +QEK + +EK ++ +I+
Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 807 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
E++ + + + + +E+KI+ + + + K + E +KI+++++ EK H + EK +
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE-QEKIRKQEEKVWRQEEKMHDQEEKIR 512
Query: 867 NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 925
K EK RE+ ++ + +EK ++ + + +E+ + E++ K + + + E+
Sbjct: 513 EQEE-KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Query: 926 GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 985
+++++ ++KEK R++E + I+E+++ + Q EK +EK ++
Sbjct: 572 KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM-----QEQEEKMWEQEEKMCEQE 626
Query: 986 LKTPDGKEKDKKDKD 1000
K + +EK ++ ++
Sbjct: 627 EKMQEQEEKMRRQEE 641
Score = 91.3 bits (225), Expect = 9e-18
Identities = 76/360 (21%), Positives = 183/360 (50%), Gaps = 24/360 (6%)
Query: 618 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 677
K ++E K ++ + ++ EK + ++E+ EKE+ K + + + E R + +
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 678 FKSDETEDLFLNMEHESLTLEKKSKL--EKNIKDDKSTKEKHVS---KERNFKEERDKIK 732
K ++ +L M + E++ K E+ I++ + +E+ +E +E+ +KI+
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 733 KESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 791
++ +K +R EEKI + ++ RE + E M EE I ++EI +K++ H
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKIR---EQEEIWRQKEKMH 485
Query: 792 IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKL 850
+E K E++ +E+ + E K E+E+K+ + E K + + + E +KI+E++++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 851 YSHHTEKCHKEGEKSKNTAAIKKTDDR-----EKSREKMDRKHDKEKP--EKERHLAESK 903
EK ++ EK + +++ +++ EK RE+ ++ ++E+ E+E + E +
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE-Q 604
Query: 904 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963
E+ + E++ K + E ++ K +E++ ++ ++E+ ++ + + + +E + +
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 79.7 bits (195), Expect = 3e-14
Identities = 112/534 (20%), Positives = 232/534 (43%), Gaps = 90/534 (16%)
Query: 626 TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 685
T +K +L+ + K++EGE +D L S +F E E + T+
Sbjct: 136 TCQKTELQMALYYSQHAVKQLEGE-----ARDLISRLHDSWKFAGEL--EQALSAVATQK 188
Query: 686 LFLNMEHESLTLEKKS---KLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 742
+ E LT E+ + +L +N D+ KEK+ + + ESEKS +
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ------LVESEKSEIQL 242
Query: 743 KIKDLKEEREN----IPTDK-DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE 797
+K+LK + E +P + +E LG S L +E ++ + +E K
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM 302
Query: 798 -KPEKRSQIKEKDIEKMERKTFEKEKKIKH-EHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
+ E++ Q E+ I++ E K E+E+KI+ E K + + + E +K++ ++++
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362
Query: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 915
EK + E + EK RE ++ H++EK + E +EK E+K ++
Sbjct: 363 EKMRRLEEMM--------WEKEEKIRELEEKMHEQEK------IREQEEKRQEEEKIREQ 408
Query: 916 DNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 975
+ + +++ + +EK RE ++K + ++K+ QEEK HE+
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR-------QEEKI----------HEQ-- 449
Query: 976 SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSP 1035
EK ++++ +E + ++KI + + E + K K
Sbjct: 450 -----------------EKIREEEKRQEQEEMWRQEEKI------REQEEIWRQKEKMHE 486
Query: 1036 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK-----EKIKQKEKERLRNR 1090
K + +EK ++ M E+ +++ E + W ++ K EKI+++E E++R +
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEK---IREQEEKMWRQEEKIREQEEKIREQE-EKIREQ 542
Query: 1091 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSV 1144
E+ + +EK + + +E R + ++ + K ++ K+ + + + +
Sbjct: 543 E--EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Score = 78.6 bits (192), Expect = 6e-14
Identities = 78/392 (19%), Positives = 192/392 (48%), Gaps = 36/392 (9%)
Query: 578 KHKEKSKHQKDFHLEFGEK---SNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 634
+ +EK Q++ E+ EK KI++++ K ++E K ++ ++
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----------KIREQEEKMRRQEEMMW 345
Query: 635 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHES 694
++ EK + ++E+ EKE+ K + + + E RE +E + ++ + + E
Sbjct: 346 EKEEKMRRQEEMMWEKEE-KMRRLEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQEEE 403
Query: 695 LTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 754
E++ + E+ K + +EK +E +E+ K+ ++ EK +EKI++ ++ +E
Sbjct: 404 KIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 462
Query: 755 PTDKDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEK---PEKRSQIKE 807
+ E + +H EK E + +QE+ + + +EK E++ +E
Sbjct: 463 EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522
Query: 808 KDIEKMERKTFEKEKKIKHEHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
+ I + E K E+E+KI+ + + +++ + + E +K++E++K+ EK ++ EK +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM-RRQEEKIREQEEKIR 581
Query: 867 NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 925
+ +EK RE+ ++ +EK ++ + + +E+ + E++ K + E + ++
Sbjct: 582 --------EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 926 GKNKEKDRELDKKE-KSRDKESINITNSKHIQ 956
K + ++ ++ ++E + R +E + +H++
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 62.4 bits (150), Expect = 4e-09
Identities = 95/553 (17%), Positives = 223/553 (40%), Gaps = 107/553 (19%)
Query: 355 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 411
R+ + E+ KE + ++ + EK+ + K K+K R +L ++ + L
Sbjct: 211 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270
Query: 412 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 466
+ S S + + +++ Q ++E + E K + ++ + + K +E +E
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 467 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 526
+E+E K + + + EK R + + K++ L + K K
Sbjct: 331 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRLEEMMWEKEEK---- 378
Query: 527 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 586
+ E + +QE + E ++ R + E++ + ++ + K + + +
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEK 437
Query: 587 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 646
K + E KI++E+ K+ ++E ++ EK + ++EI
Sbjct: 438 KMWRQEEKIHEQEKIREEE------------KRQEQEE--------MWRQEEKIREQEEI 477
Query: 647 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 706
+KEK ++ ++ + V W++ EK E+
Sbjct: 478 WRQKEKMHEQEKIRKQEEKV------WRQE---------------------EKMHDQEEK 510
Query: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 766
I++ +EK +E +E+ +KI+++ EK +E++ +EE+ +K E +
Sbjct: 511 IREQ---EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 767 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 826
+E I +QE+ I+E KEK I + E K +E+E+KI+
Sbjct: 568 -------------RQEEKIREQEEKIREQKEK-----------IREQEEKIWEQEEKIRE 603
Query: 827 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDR 886
+ + ++ +++K++ + C +E + + +++ +++ +E R
Sbjct: 604 QEEMMQE------------QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 651
Query: 887 KHDKEKPEKERHL 899
+ +++ E + HL
Sbjct: 652 QQEEKMQEHQEHL 664
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 109 bits (273), Expect = 2e-23
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 66/621 (10%)
Query: 432 QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEK 491
+++KE V+ E ++ +V ++ + + + +E +E+EG E T +E+
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 492 TREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM 551
KS ++ S + KSP+ E+ +P + + + SP E
Sbjct: 509 AASPEKEAKSPVKEEAKSP-----AEAKSPE-----KEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 552 SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFE 611
P+ + E++ E S + K K + + + EK+ + +K+E SP
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 612 NSDCTLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR 670
S + K E K+ +K K KE K K + EKE+ K+ + AK ++
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK-SPEKEEAKSPEKAKSPVKAEA--- 674
Query: 671 EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVS--KERNFKEER 728
KS E + E +S K + +K++ + EK S KE E+
Sbjct: 675 --------KSPEKAKSPVKAEAKS-----PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 729 DKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQ 788
K + E E+ +KEE ++ K E K +D++
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA-----------------KTLDVKSP 764
Query: 789 EKHI--KESKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKS-EKDKLDLSECVDKI 844
E KE P + K K K E K+ EK K +K + K+ EK+ E +
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Query: 845 KEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKE 904
KE++K ++ K+ E+ K A KT++++ S+++ K + KP+ E + E
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEK-APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 905 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 964
K K + + +E K KE +++ KE ++ KE +
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK------------ 931
Query: 965 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1024
+ + A+ ++P EK + P K +EK KK ++ + + + K DK S K
Sbjct: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL--SKEPSKP 989
Query: 1025 EADKPKPKSSPASKDTRPKEK 1045
+A+K + SS KD++P EK
Sbjct: 990 KAEKAEKSSSTDQKDSKPPEK 1010
Score = 101 bits (252), Expect = 7e-21
Identities = 147/633 (23%), Positives = 262/633 (41%), Gaps = 52/633 (8%)
Query: 325 LPSKTP-LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 383
LP P +PS + K ++ ++ + + ++ +EQ +E + E T K+ K
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481
Query: 384 YPKSFKSKKQKPSRVLYSSTESSD-EEALQNKKISTSCSVIPETSNSDMQTK----KEYV 438
K + +++ + T+S EEA +K + S + E + S + K +E
Sbjct: 482 EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS--PVKEEAKSPAEAKSPEKEEAK 539
Query: 439 VSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF 498
E K K K K + K+ + +++E K + + E+ +
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPAEA 598
Query: 499 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 558
+ K + KSP + E+ +P + + + SP + E + P+
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSP-----VKEEAKSPAEVKSPEKAKSP-TKEEAKSPEKA 652
Query: 559 RYDNTESEFLPES--SSVKS-CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDC 615
+ E PE S VK+ K EK+K + EK+ + +K+E SP S
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712
Query: 616 TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ-RSVEFDREFW 673
+ K ++ K+ K + K E+ K K+E + EK K+ + AK L +S E
Sbjct: 713 KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-EKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 674 KENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 733
+E +D+ + + E + +K+K +K+D EK + K KEE K
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAK--SPLKEDAKAPEKEIPK----KEEVKSPVK 825
Query: 734 ESEKSFREEKIKD--LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 791
E EK +E K+K+ K E E P +E ++S +KE K E+
Sbjct: 826 EEEKP-QEVKVKEPPKKAEEEKAPATPKTEEK-------KDSKKEEAPKKEAPKPKVEEK 877
Query: 792 IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY 851
+ + EKP K S+++ K E E +KK+ K K+++ E K KEK
Sbjct: 878 KEPAVEKP-KESKVEAKKEEA------EDKKKVPTPEKEAPAKVEVKEDA-KPKEK---- 925
Query: 852 SHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKK 911
TE KE + +K K + +E + EK D K +K K +E+ E+K K +
Sbjct: 926 ---TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL 982
Query: 912 NKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944
+K+ + K+EK + ++ ++ + DK
Sbjct: 983 SKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 100 bits (249), Expect = 1e-20
Identities = 144/580 (24%), Positives = 250/580 (43%), Gaps = 60/580 (10%)
Query: 578 KHKEKSKHQKDFHLEFGEKSNAKIKDED-HSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 636
+ ++++K ++ E GE+ A+ +E+ SP E + K+ K K + K
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 637 REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 696
EKE+ K E K K K AKE +S + KE E + + E
Sbjct: 533 PEKEEAKSPAE-VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK----SPEKAKSP 587
Query: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 756
++++K K + K + ++ E + +K+E+ KS E K E+ PT
Sbjct: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA-KSPAEVK----SPEKAKSPT 642
Query: 757 DKDSEFTSLGMSAI-EESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 815
++++ S EE+ + + E + +S K E +S K K K E
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA 702
Query: 816 KTFEKEKK-IKHEHKS-EKDKLDLSE---CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 870
K+ EK K +K E KS EK K + E +K K K + EK K EK+K T
Sbjct: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-KSPEKAK-TLD 760
Query: 871 IK----KTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 925
+K KT +E++R D+ +K K P KE + K K + K++ ++ E K E+
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL-KEDAKAPEKEIPKKEE 819
Query: 926 GKN----KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT 981
K+ +EK +E+ KE + E + +E+K S + K + KP ++EK
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKK 878
Query: 982 KDEPLKTPDGKEKDKKDKDIDRYKERDKHKD-----KIQINSLLKLKSEADKPKPKSSPA 1036
+ K + K + KK++ D+ K K+ +++ ++ K K+E K +P + A
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 1037 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1096
+ ++P EK+ + T E+ KK +EK K E K
Sbjct: 939 KEPSKPAEKKEAAPEKKDTKEEKA------------KKPEEKPK------------TEAK 974
Query: 1097 IKDKEKT-KHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1135
K+ +KT P++ K ++ +S S++ D+ EK +D
Sbjct: 975 AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 92.0 bits (227), Expect = 5e-18
Identities = 103/480 (21%), Positives = 206/480 (42%), Gaps = 16/480 (3%)
Query: 679 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 738
KS+E + E E++ +E++++ E + ++ + +E+ +KE KEE ++E+E
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 739 FREEKIKDLKE----ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 794
E K +E E+E K+ + + E+ E + + + +E
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 795 SKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKSEKDKLDLSECVDKIKEKDKLYSH 853
+K PE +S KE+ E K+ EK K K E KS + + +KE+ K
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK---S 614
Query: 854 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKN 912
E E++K+ A +K + + ++ + +K K PEKE + K K ++ +
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 913 KQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQEEKKSSIVDGNKAQH 971
K + ++ + K+ EK + K+E KS +K + E+ KS + + K
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 972 EKPLSLKEKTKD-EPLKTPD-GKEKDKKDKDIDRYKERDKHK--DKIQINSLLKLKSEAD 1027
+ +KE+ K E K+P+ K D K + + + DK + +K E
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 1028 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1087
P+ SP +D + EK + + +++ + +++++++ KK +E+ +
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 1088 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1147
++ + + KE K E K + + K S+V +A +E + K V + K
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV-EAKKEEAEDKKKVPTPEKEAPAK 913
Score = 72.8 bits (177), Expect = 3e-12
Identities = 95/404 (23%), Positives = 163/404 (40%), Gaps = 28/404 (6%)
Query: 787 KQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKIKHEHKSEKDKLDLSECVDK 843
K E+ IK EK EK + I E+ E+ E T E+EK+ K E E++ + E
Sbjct: 439 KSEEKIKVV-EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 844 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 903
+E + KE + A K+ KS EK + K E E+ + +K
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 904 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963
E+ + K + E + K+ EK + K+E E+ + +K +E+ S
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 964 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1023
+ E+ S E E K+P +E +K KE K +K + +K
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK----SPVK 671
Query: 1024 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKE 1083
+EA P+ SP + + EK S E+ S E + +K K +K++
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS-PEKAKSPVKEEA 730
Query: 1084 KERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEV-TDAYTKEKQPKDAVSNRSQ 1142
K + ++ ++ + K EK K +P ++K ++ KS E T A + + P D +++
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAK-SPEKAKTLDV---KSPEAKTPAKEEARSPADKFPEKAK 786
Query: 1143 SVDTKNVMTLGKSSF------------VSDNSLNRSPRSENEKP 1174
S + V + K+ + +SP E EKP
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Score = 71.2 bits (173), Expect = 9e-12
Identities = 101/464 (21%), Positives = 182/464 (39%), Gaps = 52/464 (11%)
Query: 741 EEKIKDL-KEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 799
EEKIK + K E+E + ++ +E T + EE +EK KE + K
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE---------------EEKEAKEEEGKE 485
Query: 800 EKRSQIKEKDIEKMERKT------FEKEKKIKHEHKSEKDKLDLSECVDK--------IK 845
E+ + +E + + E K+ EK+ K K E ++ +K +K
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 846 EKDKLYSHHTEKCHK-------EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 898
+K S E+ E E++K+ A + K+ ++ KS K + K E E+
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-KSPEKAKSPAKEEAKSPAEAKSPEKA 604
Query: 899 LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQE 957
+ KE+ + K E + K+ EK + K+E KS +K E
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 958 EKKSSIVDGNKAQHEKPLSLKEKTKD-EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQI 1016
+ KS + K+ + +K + K E K+P +E +K KE K +K +
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK- 723
Query: 1017 NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK 1076
+K EA P+ SP ++ + EK + L +K E + K+
Sbjct: 724 ---SPVKEEAKTPEKAKSPVKEEAKSPEK------AKSPEKAKTLDVKSPEAKTPAKEEA 774
Query: 1077 EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1136
K E+ ++ E+K +K K+ ++K E K EV +E++P++
Sbjct: 775 RSPADKFPEKAKSPVKEEVKSPEKAKSP-LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833
Query: 1137 -VSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSR 1179
V + + + K+ D+ +P+ E KP + +
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Score = 66.6 bits (161), Expect = 2e-10
Identities = 97/471 (20%), Positives = 170/471 (36%), Gaps = 40/471 (8%)
Query: 864 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 923
K K+ IK + EK E + + E+ + + E +EK E++ K+ + E ++
Sbjct: 437 KVKSEEKIKVVEKSEK--ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 924 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK--AQHEKPLSLKEKT 981
E G+ + K ++ + + E KS + K A+ + P K
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 982 KDEPLKTPDGKEKDKKD-KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDT 1040
K+E P+ K +K++ K K +K K + + K +EA P+ SP ++
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA--KSPAEAKSPEKAKSPVKEEA 612
Query: 1041 R-PKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRN----RNCLEL 1095
+ P E + + ++ E K + K EK K EKE ++ ++ ++
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672
Query: 1096 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1155
+ K EK K +P +++ K ++KS +A + EK K V ++S + KS
Sbjct: 673 EAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEK------AKS 724
Query: 1156 SFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESS 1215
+ +S ++ S A + D TP +
Sbjct: 725 PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP--------------A 770
Query: 1216 ESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLII 1275
+ + F AKSP E PE+ K P E+VK +
Sbjct: 771 KEEARSPADKFPEKAKSPVKEE------VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Query: 1276 SEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPE 1326
E EV+ P E +EE P +P PK E
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Score = 64.3 bits (155), Expect = 1e-09
Identities = 77/376 (20%), Positives = 153/376 (40%), Gaps = 28/376 (7%)
Query: 799 PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKC 858
P + IK K E+KIK KSEK+ + + E ++ + TE+
Sbjct: 430 PSVSTHIKVK-----------SEEKIKVVEKSEKETVIVEEQTEE--------TQVTEEV 470
Query: 859 HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNS 918
+E EK K+ + E+ + + K P +E E + K ++++ K +
Sbjct: 471 TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530
Query: 919 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 978
+ + E+ K+ + + +K + +E+ + +K ++E+ S A+ + P K
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS-----PAEVKSPEKAK 585
Query: 979 EKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK 1038
K+E K+P + +K K + + + + K + K +E P+ SP +
Sbjct: 586 SPAKEE-AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 1039 DTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK 1098
+ + EK + S E+ S E + +K K +K + K + ++ ++ + K
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS-PEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 1099 DKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFV 1158
EK K +P + + K ++KS +A T EK K V ++S + K+ V
Sbjct: 704 SPEKAK-SPVKEEAKSPEKAKSPVKEEAKTPEK-AKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 1159 SDNSLNRSPRSENEKP 1174
+ E P
Sbjct: 762 KSPEAKTPAKEEARSP 777
Score = 47.4 bits (111), Expect = 1e-04
Identities = 86/438 (19%), Positives = 166/438 (37%), Gaps = 38/438 (8%)
Query: 29 KSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKT 88
K+K + +K+P +S V +E K + +K P EE S + + PEK++
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS--PEKAKSPTKEEAKSPEKAKSPEKEEA 660
Query: 89 KKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSP----DSTPNHPSQTTPAQKKT 144
K + K +PV P + + + + SP +P + K+
Sbjct: 661 K--SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 145 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 204
P + + K E+ ++P+ A + + E ++VK TP E
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE---KAKTLDVKSPEAKTPAKEEAR 775
Query: 205 VGYYDVAKILIAAGADVNTQGLDDD---TPLHDSASSGHRDIVKLLLRHGGNPFQANKHG 261
K A + V + + +PL + A + ++I K +P K
Sbjct: 776 ---SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK--KEEVKSPV---KEE 827
Query: 262 ERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETE------KD 315
E+P +V E + + + P + E DS++ ++ + ++ + E K+
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 316 SLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKE----QRKENEPEAE 371
S + K+ K +P+ E K + E+ K + + +KE + KE AE
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-KPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 372 KTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDM 431
K A ++K + K ++KP + D++ L + ++S++D
Sbjct: 947 KKEA-APEKKDTKEEKAKKPEEKPKT---EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 432 QTKKEYVVSGEHK-QKGK 448
+ K + E K KGK
Sbjct: 1003 KDSKPPEKATEDKAAKGK 1020
Score = 37.7 bits (86), Expect = 0.12
Identities = 35/149 (23%), Positives = 56/149 (37%), Gaps = 37/149 (24%)
Query: 18 DSNMVEKPYGRKSKDKIASYSKTPKIERSDVSK--EMKEKSSMKRKLPFTISPSRNEERD 75
DS E P K K+ K P +E+ SK KE++ K+K+P
Sbjct: 858 DSKKEEAPKKEAPKPKVEE-KKEPAVEKPKESKVEAKKEEAEDKKKVP------------ 904
Query: 76 SDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPS 135
EKE P K + K++A K+ T V A+ D+ PS
Sbjct: 905 -TPEKEAPAKVEVKEDAKPKEKTEV---------------------AKKEPDDAKAKEPS 942
Query: 136 QTTPAQKKTPSSSSRQKDKVNKRNERGET 164
+ ++ P +++K K E+ +T
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971
Score = 34.7 bits (78), Expect = 0.98
Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 30/166 (18%)
Query: 24 KPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR--KLPFTISPSRNEERDSDTEKE 81
K R DK +K+P E +V K KS +K K P P + E + E+E
Sbjct: 771 KEEARSPADKFPEKAKSPVKE--EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828
Query: 82 GPEKKKTK---KEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPS-QT 137
P++ K K K+A +K+ P +E K +D+ + P + +
Sbjct: 829 KPQEVKVKEPPKKAEEEKAPAT------PKTEEK----------KDSKKEEAPKKEAPKP 872
Query: 138 TPAQKKTPSSSSRQKDKVNKRNERGE------TPLHMAAIRGDVKQ 177
+KK P+ ++ KV + E E TP A + +VK+
Sbjct: 873 KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 104 bits (259), Expect = 1e-21
Identities = 205/919 (22%), Positives = 352/919 (38%), Gaps = 166/919 (18%)
Query: 360 KEQRKENEPEAEKTHLFAKQEKA-FYPKSFK-SKKQKPSRVLYSSTESSDEEALQNKKIS 417
KE+ E+ + EK+ + E PKS + S P + + T+ + L NK +
Sbjct: 249 KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQ 308
Query: 418 TSCSVIPETSNSDMQTKKEYVVSGEHKQ--KGKVKRKLKNQNKNKENQELKQEKEGKENT 475
S S + K + GE K+ K K ++K + K+++ Q++K EK+ KE
Sbjct: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK- 367
Query: 476 RITNLTVNTGLDCSEKTREEGNFRKSFSPKDD---------------TSLHLFHISTGKS 520
+ +L + + + ++ EG ++ FS D + L F T +
Sbjct: 368 EVESLKLPSEKNSNKAKTVEGT-KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
Query: 521 PKHSCGLSEKQSTP-----LKQEHTKTCLSPGSSEMSL--------QPDLVR--YDNTES 565
S + E + T KQ TKT S S + +P L Y +++
Sbjct: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486
Query: 566 EFLPESSSVKSCKHKEKSKHQKDFHLE-FGEKSNAKIK-----------------DEDHS 607
E E K KE+ ++ + E EK K + +E +
Sbjct: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
Query: 608 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 667
+ E +K++ KE K L+K K+R+K+ E +K++ +DS + L+ S
Sbjct: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
Query: 668 FDREFWKENFFKSDETEDLFLNME--------HESLTL----EKKSKLEKNIKDDKST-- 713
+ KE S E + + E ESL + + +SKLE+ K ST
Sbjct: 607 CE----KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
Query: 714 ------------------------KEKHVSKERNFKEERDKIKKESE----KSFREEKIK 745
E+ ++ K E+ K +SE KS ++++K
Sbjct: 663 IMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVK 722
Query: 746 DLKE--ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 803
KE ERE P++ L + + +H E ++ EK +K + ++
Sbjct: 723 SSKEKPEREKTPSE-----DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQ 777
Query: 804 QIKEKDIEKMERKTFEKEKKIKHEHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHK 860
Q K +K ERK+ K ++E K KD +SE + K E K
Sbjct: 778 QTKLSSDDKTERKS-----KHRNERKLSVLGKDGKPVSEYIIKT----------DENVRK 822
Query: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH---LAESKEKHLMEKKNKQSDN 917
E K + + +KT KSR D K K+ ++H L E + +K + S N
Sbjct: 823 ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882
Query: 918 SEYS-KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 976
+ + K E+ +KEK R E+ +S + T K + + ++ + +G Q P
Sbjct: 883 MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQV-KVVETELQEGATKQATTPKP 941
Query: 977 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK-LKSEADKPKPKSSP 1035
KEK +E + EK +K K DK ++ + +L+ S A + SS
Sbjct: 942 DKEKNTEE-----NDSEKQRKS------KVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990
Query: 1036 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLEL 1095
+K KEK + D T ER LS HK K K+
Sbjct: 991 RAKLPLAKEKYKSDKDSTSTRLERKLS-------DGHKSRSLKHSSKD------------ 1031
Query: 1096 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1155
IK K++ K + K + + K + + ++K + NR S+ + M G+
Sbjct: 1032 -IKKKDENKSDDKDGKEVDSSHEK-ARGNSSLMEKKLSRRLCENRRGSLSQE--MAKGEE 1087
Query: 1156 SFVSDNSLNRSPRSENEKP 1174
+ N+L+ S ++P
Sbjct: 1088 KLAA-NTLSTPSGSSLQRP 1105
Score = 74.7 bits (182), Expect = 9e-13
Identities = 111/522 (21%), Positives = 207/522 (39%), Gaps = 62/522 (11%)
Query: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKK--------IKHEHKSEKDKLDLSECVDKI 844
+ SK+ P + + D E+ +KEK ++ KSE+ DL V++I
Sbjct: 232 RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEI 290
Query: 845 KEKDKLY--------------SHHTEKCHKEGEKS--KNTAAIKKTDDREKSREKMDRKH 888
K K + S K +GEK N +K + +EK+ +K D
Sbjct: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK 350
Query: 889 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE---KDRELDKKEKSRDKE 945
E +K + ++KEK + K NS +K+ +G ++ D ++D
Sbjct: 351 KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVS 409
Query: 946 SINITNSKHIQEEKKSSIV------DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK 999
S++ ++ +E+ + +V +G ++ + + KTK + + +GK K +
Sbjct: 410 SVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHA 469
Query: 1000 DIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK--EKRLVNDDLMQTS 1056
+ + Y + D ++ + + K K + + R K EKR + ++S
Sbjct: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS 529
Query: 1057 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI----KDKEKTKHTPTESKN 1112
+ +++E+ K E + KE L+ R LE K+ K K+ +++ SK
Sbjct: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589
Query: 1113 KELTRSKSSEVTDAYTKEKQPKDAVSN-------RSQSVDTKNVMTLGKSSFVSDNSLNR 1165
K+ S E T E K+ +S+ ++S +K L +S V D + N
Sbjct: 590 KQQYEEDSKETLK--TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647
Query: 1166 SPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPV-----EYDSDFMLESSESQMS 1220
S + E E +S V M V D+ R + + + +
Sbjct: 648 S-KLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
Query: 1221 FSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSH 1262
S++P L +L ++E+ S + PER K P ++LS H
Sbjct: 707 DSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
Score = 74.3 bits (181), Expect = 1e-12
Identities = 202/1040 (19%), Positives = 387/1040 (37%), Gaps = 161/1040 (15%)
Query: 3 KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62
K TK S++S+ + V Y K YSK +++ E + +S K K
Sbjct: 447 KQNKTKTQTSDSSEGKTKSVRHAYVHKPY----LYSKYYSDSDDELTVEQRRQSIAKEKE 502
Query: 63 PFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKST------------PVSILFGYPLSE 110
+ N E+ + K+ EK K+ K G +S+ P + L E
Sbjct: 503 ERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE 562
Query: 111 RK----QMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSR-QKDKVNKRNERGETP 165
RK ++AL + + + Q K+T +S +K+K++ E
Sbjct: 563 RKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKE----- 617
Query: 166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 225
+ + + K L +++V D E N + + V +G
Sbjct: 618 --LKHVHAKSEPSKPARRLSESLHVVD--------ENKNESKLE-REHKRRTSTPVIMEG 666
Query: 226 LDDDTPLHDSASSGHR-DIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLS 284
+ ++T D R +I + + + KH ++ D +ET L+ LLK+EV S
Sbjct: 667 VQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKK--DDSETPHLKSLLKKEVKSS 724
Query: 285 DD--DESYTDSEEAQSVNPS--------SVDENIDSETEKDSLICESKQILPSKTPLPSA 334
+ + T SE+ SV + DE +EK + E+ Q +T L S
Sbjct: 725 KEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSD 784
Query: 335 -LDEYEFKDDDDEEINKMIDD-----RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSF 388
E + K ++ +++ + D +I++ ++ E ++ L A++ KA +
Sbjct: 785 DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEH---- 840
Query: 389 KSKKQKPSRVLYSSTESSDEE-ALQNKKISTS---CSVIPETSNSDMQTKKEYVVSGEHK 444
KS++ S++ S S LQ + S S C + +++N D K E VV HK
Sbjct: 841 KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM--DSTNMDSNLKPEEVV---HK 895
Query: 445 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 504
+K + K L+ + K K + +GK+ + E +EG +++ +P
Sbjct: 896 EKRRTKSLLEEKLVLKS----KSKTQGKQ------------VKVVETELQEGATKQATTP 939
Query: 505 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM-SLQPDLVRYDNT 563
K D + + K K S+ + P ++ + L SS S Q D
Sbjct: 940 KPDKEKNTEENDSEKQRK-----SKVEDKPFEETGVEPVLETASSSAHSTQKD------- 987
Query: 564 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 623
S K KEK K KD + K+ D S + ++S +KK D+
Sbjct: 988 ------SSHRAKLPLAKEKYKSDKD---STSTRLERKLSDGHKSRSLKHSSKDIKKKDEN 1038
Query: 624 GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ---RSVEFDREFWKENFFKS 680
+ +K KE++ EK + S E + R E R + K
Sbjct: 1039 -------------KSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKG 1085
Query: 681 DE--------------------TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
+E + D+ L E E + ++ + +E + K+ ++ +
Sbjct: 1086 EEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNS 1145
Query: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
+++ E K +K S ++E + + P K T + ++ + + +
Sbjct: 1146 QQDIDSENMK-QKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLT 1204
Query: 781 KEIDIEKQEKHIKESKEKPEKRSQIKEK-DIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839
K++ I+ + +++P R + D E + R + K+ K+ +
Sbjct: 1205 KKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKN----TA 1260
Query: 840 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHL 899
+ + + D H T + S + +++ RE + DK +
Sbjct: 1261 AEEHVAQGDATLEHSTNL-----DSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTA 1315
Query: 900 AESKEKH-LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEE 958
+ S H + ++ SE K+ K + +D K+ +IT+ +HI E
Sbjct: 1316 STSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKA------SITSKRHIPEA 1369
Query: 959 KKSSIVDGNKAQHEKPLSLK 978
+++++DG + + PL K
Sbjct: 1370 HQATLLDGKQGKVIMPLGSK 1389
Score = 52.0 bits (123), Expect = 6e-06
Identities = 61/318 (19%), Positives = 138/318 (43%), Gaps = 29/318 (9%)
Query: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK-HLMEKKNKQ 914
E+ H E ++ +K D+ E KE E+ERH+ + K K H + +++
Sbjct: 2726 EEIHSESYNKGEISSGRK-DNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784
Query: 915 SDNSEY--SKSEKGKNK--EKDRELDKKEKSRDKESINITNSK------HIQEEK---KS 961
DN + S+ E + + E + K+E SRD E + T+S+ + EEK S
Sbjct: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844
Query: 962 SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK 1021
S G K + ++K + +D+P+ + + +K K +D K I ++ +
Sbjct: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904
Query: 1022 LKSEADKPKPKSSPASKDTRPKEKRLVNDD----LMQTSFER--------MLSLKDLEIE 1069
S + ++ ++K+T ++R +++D + TS R + D E
Sbjct: 2905 SPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964
Query: 1070 QWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTK 1129
+ +K ++ + +++ + E + +++++ T S + + ++++ + +
Sbjct: 2965 EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024
Query: 1130 EKQ--PKDAVSNRSQSVD 1145
+++ P A + Q V+
Sbjct: 3025 KREVSPPGARTRGQQRVE 3042
Score = 50.4 bits (119), Expect = 2e-05
Identities = 93/503 (18%), Positives = 180/503 (35%), Gaps = 91/503 (18%)
Query: 489 SEKTREEGNFRKSFSPKDDTSL------HLFHISTGKSPKHSCG-------LSEKQSTPL 535
+EKT ++ + RKSF + D + ++ I +SP + G L + P
Sbjct: 2619 AEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
Query: 536 KQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGE 595
++E L+P S +P + E + ES +V E
Sbjct: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNV--------------------E 2718
Query: 596 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 655
S + +E HS ++ + + + D + + H ++ +E E+ ++ + K K
Sbjct: 2719 NSGFRTNEEIHSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHY 2777
Query: 656 KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKE 715
S E D+ D+ S++E + T E
Sbjct: 2778 LSSEDE------------------PDDNPDVL------------DSRIETAQRQCPET-E 2806
Query: 716 KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG 775
H +KE N ++ + K SE + ++ + K+E + T + E++
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKP---------EQNDD 2857
Query: 776 LHLVEKEIDIEKQEKHIKESKEKPEK---RSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 832
+ +E E Q IK + +P K + +K KD K + + E
Sbjct: 2858 DTIKSQE---EDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI------VTVEQSPSS 2908
Query: 833 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK 892
KL + + + KE L + +GE+ T+ ++ K + + D E
Sbjct: 2909 SKLKVMQTDESNKETANLQERSIS--NDDGEEKIVTSVRRRG---RKPKRSLTVSDDAES 2963
Query: 893 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 952
E ER +S + +KK ++SD E + E + R + E R K ++ +
Sbjct: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIK 3023
Query: 953 KHIQEEKKSSIVDGNKAQHEKPL 975
+ + + G + E P+
Sbjct: 3024 RKREVSPPGARTRGQQRVEEAPV 3046
Score = 40.4 bits (93), Expect = 0.018
Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 58/338 (17%)
Query: 213 ILIAAGADVNTQGLDDDTPLHDSA------SSGHRDIVKLLLRHGGNPFQANKHGERPVD 266
+L+ +V G + +H + SSG +D + + H D
Sbjct: 2709 LLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVE-----------AD 2757
Query: 267 VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS------ETEK------ 314
E EE E R +P + Y SE+ NP +D I++ ETE
Sbjct: 2758 PKEVEEEE----RHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813
Query: 315 -----DSLICESKQILPSKTPLPSALDEYEFKD--------DDDEEINKMIDDRHILRKE 361
+ L S + + + + DEY + +DD+ I +D+ I+ K
Sbjct: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
Query: 362 QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS----RVLYSSTESSDEEALQNKKIS 417
+R +T L K + + +Q PS +V+ + + + LQ + IS
Sbjct: 2874 KRGRPRKYPVETTLKMKDDSK-TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSIS 2932
Query: 418 TSC---SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN---KNKENQELKQEKEG 471
++ + K+ VS + + +++ K+ + ++K+ QE +E+E
Sbjct: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
Query: 472 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTS 509
+E + T + SE R + S K + S
Sbjct: 2993 EEEDEPSGATTRS-TTRSEAQRSKTQLSPSIKRKREVS 3029
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 103 bits (257), Expect = 2e-21
Identities = 121/568 (21%), Positives = 261/568 (45%), Gaps = 79/568 (13%)
Query: 580 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 630
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 631 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 689
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 690 MEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFK---------EERDKIKKESEK 737
E E+K + ++ + K++K +++ + E+ K E+ +KI++ EK
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 399
Query: 738 SFREEKIKDLKEER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 794
+EKI++ +E+R E I + + M EE I E+E I +QEK +
Sbjct: 400 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWR 455
Query: 795 SKEKPEKRSQIKEKDIEKMERKTFEKEKKI--------------KHEHKSEKDKLDLSEC 840
+EK ++ +I+E++ + + + + +E+KI + E K K + +
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 841 VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA 900
+KI+E+++ EK ++ EK I++ ++ + EKM H++EK +E
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEK------IREQEEMWREEEKM---HEQEKIWEEEKRQ 566
Query: 901 ESKEK-HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK 959
E ++K E+K ++ + + + EK + +E+ R+ +++ + +E I K ++E+
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 960 KSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK--DKKDKDIDRYKERDKHKDKIQIN 1017
K + Q EK +E T+++ K + +EK ++++K ++ + + ++KI+
Sbjct: 627 KI------REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR-- 678
Query: 1018 SLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE 1077
E +K K +EK +++MQ E+M ++ EQ K ++
Sbjct: 679 -------EQEK---------KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722
Query: 1078 KIKQKEKERLRNRNCLELKIKDKEKTKH 1105
+ K + +E + L+ ++++ +H
Sbjct: 723 EEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 80.5 bits (197), Expect = 2e-14
Identities = 113/575 (19%), Positives = 256/575 (44%), Gaps = 88/575 (15%)
Query: 346 EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 405
+E+ + ++ +L +Q+ + AE HL K S K + Q L++
Sbjct: 245 KELKRKLERAKLLLPQQQLQ----AEADHL----GKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 406 SDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQ 463
EE + Q +KI I E ++ ++E + E K + + + + + K + +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEK-IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 355
Query: 464 ELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKH 523
E+ EKE EK R + + K++ + K K
Sbjct: 356 EMMWEKE-------------------EKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK- 392
Query: 524 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 583
+ E + +QE + E ++ R + E++ + ++ + K +
Sbjct: 393 ---IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIRE 448
Query: 584 KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK-EKH 642
+ +K + E KI++E+ E +K+ ++ + ++ + H++ EK K
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ 508
Query: 643 KKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSK 702
++++ ++EK + ++ ++ E + + W++ K E E+++ E+K
Sbjct: 509 EEKVWRQEEKIREQE-----EKIREQEEKMWRQE-EKIREQEEMWRE--------EEKMH 554
Query: 703 LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEKIKDLKEERENIPTDKDSE 761
++ I ++ EK +E + +KI+++ EK +R EEKI++ +E+R+ +++ +
Sbjct: 555 EQEKIWEE----EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ----EQEEK 606
Query: 762 FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTF 818
M EE I E+E I++QE+ I+E +EK ++ ++ ++ EKM E K
Sbjct: 607 -----MWKQEEKIR----EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 657
Query: 819 EKEKKI--------KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 870
E+E+K+ + E K + + + E +KI+E++++ EK ++ EK
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK------ 711
Query: 871 IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905
+ + +++ + +E+ R+ +++ E+E L + +EK
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 46.2 bits (108), Expect = 3e-04
Identities = 66/325 (20%), Positives = 144/325 (44%), Gaps = 41/325 (12%)
Query: 806 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKS 865
K+K +E T E++ +++ +L E K++EK +L E EKS
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV---------ESEKS 238
Query: 866 K---NTAAIKKTDDREK---SREKMDRKHD---KEKPEKERHL-AESKEKHLMEKKNKQS 915
+ N +K+ +R K ++++ + D KE L A+ +E L + N+Q
Sbjct: 239 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ 298
Query: 916 DNSEYSKSEKGKN-KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKP 974
+ + + EK + +EK +E ++K + ++++ QEE + + Q E
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 975 LSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1034
+EK + + + +EK ++ +++ KE + + +++ K++ + +K + +
Sbjct: 359 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418
Query: 1035 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
R +EKR + M E++ ++ +EKI+++EK+ R E
Sbjct: 419 -----IREQEKRQEQEAKMWRQEEKI------------REQEEKIREQEKKMWRQ----E 457
Query: 1095 LKIKDKEKTKHTPTESKNKELTRSK 1119
KI ++EK + + +E+ R +
Sbjct: 458 EKIHEQEKIREEEKRQEQEEMWRQE 482
Score = 39.3 bits (90), Expect = 0.040
Identities = 56/320 (17%), Positives = 130/320 (40%), Gaps = 12/320 (3%)
Query: 819 EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 873
E I H S K +L + + + + K + E+ KE E +NT ++
Sbjct: 159 EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218
Query: 874 TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDR 933
++ ++ + + EK E + ++ E K K K + GK +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-- 276
Query: 934 ELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKE 993
+ K +++ +E+ QEEK + + EK +EK +++ K + +E
Sbjct: 277 -VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 335
Query: 994 KDKKDKDIDRYKERD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDL 1052
K ++ +++ KE + ++++ K++ + + K K R +E ++
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEK 392
Query: 1053 MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1112
++ E+M + + ++ ++ +EKI+++EK + + + K +E+ + + K
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452
Query: 1113 KELTRSKSSEVTDAYTKEKQ 1132
K E +EK+
Sbjct: 453 MWRQEEKIHEQEKIREEEKR 472
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 103 bits (257), Expect = 2e-21
Identities = 101/461 (21%), Positives = 226/461 (49%), Gaps = 37/461 (8%)
Query: 642 HKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEHE 693
HKK +E K +D+ EL R+ + E K+N E ++ LN++
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 694 SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEEREN 753
LE+ L ++ + + +E+ +E +E+ KI+K+ EK +R+E+ L+E+
Sbjct: 214 KRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--RLREQEGK 270
Query: 754 IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM 813
+ ++ M E+ L E+E ++ +QEK ++E K+ E+ Q++E++ EKM
Sbjct: 271 MREQEEK------MRRQEK----RLREQEKELREQEKELREQKKLREQEEQMQEQE-EKM 319
Query: 814 ---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 869
E K E+E+K+ + E + + + + E K++++++ E+ ++ E+ +
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379
Query: 870 AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNK-QSDNSEYSKSEKGKN 928
+ + +++ + E++ R+ +K+ E+E + E +EK +++N + + E+ + +
Sbjct: 380 KMWEQEEKMQEEERI-REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 929 KEKDRELDKKEKSRDK---ESINITNSKHI-QEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984
KEK E +K ++ +K + I + + + +EKK + + Q ++ +EK +D+
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 985 PLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKE 1044
K D +E+ + + R KE + K K++ E K+ K T +E
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE-----KKTQEQEKKTWDQE 553
Query: 1045 KRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1085
+++ ++ M+ ++M +++ EQ K +++ K +E+E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 100 bits (250), Expect = 1e-20
Identities = 116/578 (20%), Positives = 258/578 (44%), Gaps = 49/578 (8%)
Query: 580 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK 639
K+ ++ Q+ L EKS ++ ++ E + L ++ + TL++ + +E +
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV--QTNTLQEEMWRQEEELR 244
Query: 640 EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEK 699
E+ KK + E++ ++ ++ +E + + E + + E E E E L +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE---LRE 301
Query: 700 KSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD 759
+ KL + + + +EK +E +E+ +K+ ++ E+ + +EK E+E D++
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK---QMREQEQKMRDQE 358
Query: 760 SEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 819
E+ + EK + E++ + + +E+ EK+ + +E+ + + E K +
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER-EKKMREEEETMREQEEKMQK 417
Query: 820 KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI----KKTD 875
+E+ + + + E + L E +K+ E++K+ EK ++ EK ++ + KK
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 876 DREKSREKMD-------RKHDKEKP---------EKERHLAESKEKHLMEKKNKQSDNSE 919
+EK RE+ D + D+E+ E++ L E +E+ M ++ K E
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER--MREQKKMWQQEE 534
Query: 920 YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKE 979
+ EK +++ + D++EK R++E + K +EE+ + Q EK +E
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM------REQEEKMQEQEE 588
Query: 980 KTKDEPLKTPDGKEKDKKDKDIDRYKERDK-----HKDKIQINSLLKLKSEADKPKPKSS 1034
K +++ K + +EK ++++ +++ +K +DK+Q + + E +
Sbjct: 589 KMREQEEKMWEQEEK-MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE----EKMQE 643
Query: 1035 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
K +EK ++ M+ E+M ++ EQ K ++ K +E+E + R E
Sbjct: 644 QEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE-KMRGQEE 702
Query: 1095 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1132
+EK + +E R K + D K ++
Sbjct: 703 KMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 96.3 bits (238), Expect = 3e-19
Identities = 92/500 (18%), Positives = 249/500 (49%), Gaps = 54/500 (10%)
Query: 621 DKEGKTLKKH-KLKHKEREKEKHKKEI-EGEKEKYKTKDSAKELQRSVEFDREFWKENFF 678
++EGK ++ K++ +E+ + +KE+ E EKE + K ++ ++ E + + W++
Sbjct: 266 EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325
Query: 679 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 738
++ E ++ E E++ ++ + + + +E+ ++ +E+ ++++++ +
Sbjct: 326 MREQEEKMW---RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 739 FREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 798
+EEK+++ + RE ++ E T + E+E ++KQE+++ E +EK
Sbjct: 383 EQEEKMQEEERIREREKKMREEEET--------------MREQEEKMQKQEENMWEQEEK 428
Query: 799 -------PEKRSQIKEKD-IEKMERKTFEKEKKIKHEHK--SEKDKL----DLSECVDKI 844
PE++ ++ E++ +++ E K +E+E+KI+ + + ++ K+ + E D++
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 845 KEKDKLYSHHTEKCHKEGEKS-KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 903
E+++ +K + E+ + +++ ++R + ++KM ++ +K + EK+ E K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Query: 904 ----------EKHLMEKKNKQSDNSEYSKSEKGK---NKEKDRELDKKEKSRDKESINIT 950
E+ + E++ K + E + ++ K +EK RE ++K ++++
Sbjct: 549 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE 608
Query: 951 NSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKH 1010
QEEK + +K Q ++ + ++ +E ++ + K ++++K ++ ++ +
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQ---EEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 1011 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1070
++K+Q K++ + +K + + K +EK ++ M E+M ++ Q
Sbjct: 666 EEKMQ-GQEEKMREQEEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721
Query: 1071 WHKKHKEKIKQKEKERLRNR 1090
+ KE+ + +KE+++ R
Sbjct: 722 EEMREKEERIRDQKEKMQER 741
Score = 90.9 bits (224), Expect = 1e-17
Identities = 121/581 (20%), Positives = 260/581 (44%), Gaps = 71/581 (12%)
Query: 569 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 628
PE+++ + C E K H E + +I+ +DH T C KT
Sbjct: 58 PETTTSEGCHSPEDEKKASHQHQEALRR---EIEAQDH--TIRILTCQ--------KTEL 104
Query: 629 KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK-----ENFFKSDET 683
+ L + + K + GE +KD A L S F E + + K +
Sbjct: 105 ETALYYSQDAARKFEDGNLGE-----SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADR 159
Query: 684 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK-KESEKSFREE 742
L E ++L+LE L +N ++ K+K+ E ++K++ ESEKS +
Sbjct: 160 YIEELTKERDALSLE----LYRNTITNEELKKKNA-------ELQEKLRLAESEKSEIQL 208
Query: 743 KIKDLKEEREN----IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 798
+K+LK + E +P + + EE L E+E I KQE+ + +E+
Sbjct: 209 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE-----LREQEKKIRKQEEKMWRQEER 263
Query: 799 ---PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
E + + +E+ + + E++ E+EK+++ + K +++ L E ++++E+++
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 915
EK ++ EK + + ++R +EK R+ +++ ++E + E E+ +++ +
Sbjct: 324 EKMREQEEK------MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377
Query: 916 DNSEYSKSEKGKNKEKDRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 970
+ + EK + +E+ RE +KK E R++E +++ E+++ +
Sbjct: 378 QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437
Query: 971 HEKPLSLKEKTKDEPLKTPDGKEKDK-------KDKDIDRYKERDKHKDKI--QINSLLK 1021
++ L +EK +++ K + +EK + ++K + R ++ + +D++ Q +
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 1022 LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQ 1081
+ + + + + R KE+R+ M E+M K + EQ K ++ K
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ-EQEKKTWDQEEKM 556
Query: 1082 KEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1122
+E+ER+R R E K++++E+ E ++ + + E
Sbjct: 557 REEERMRER---EKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 71.2 bits (173), Expect = 9e-12
Identities = 110/580 (18%), Positives = 240/580 (41%), Gaps = 83/580 (14%)
Query: 335 LDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAE---KTHLFAKQEKAFYPKSFKSK 391
L E E K EE KM LR+++ K E E + + +QEK + + +
Sbjct: 243 LREQEKKIRKQEE--KMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 392 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 451
+QK R + +E+ + ++ + ++E + + KQ + ++
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEE--------KMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 452 KLKNQNKNK-ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSL 510
K+++Q + E E +EKE + + + E+ RE K +++T
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER---EKKMREEEETMR 409
Query: 511 HLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPE 570
K K + E++ +Q+ + +Q + E + +
Sbjct: 410 E----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 571 SS---SVKSCKHKEKSKHQKDFHLEFGEKS-NAKIKDEDHSPTFENSDCTLKKMDKEGKT 626
K +EK + Q+D E EK + + K D D L+ +KE +
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERM 523
Query: 627 LKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL 686
++ K+ +E + + KK E EK+ + ++ +E +R E +++
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-------------- 569
Query: 687 FLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 746
E E + E++ K+++ + + +EK +E +E+ +K+ ++ EK + +E+
Sbjct: 570 ---REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626
Query: 747 LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 806
++E+ E + E+E +++QE+ + E +EK ++ +
Sbjct: 627 MQEQEEM------------------------MWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 807 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK-EKDKLYSHHTEKCHKEGEKS 865
+ EKM+ ++EK + E K + + + E +K++ +++K++ G++
Sbjct: 663 REQEEKMQG---QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMW----------GQEE 709
Query: 866 KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905
K +K +E+ REK +R D+++ +ER L E +E+
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQER-LPEHEER 748
Score = 38.9 bits (89), Expect = 0.052
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 13/201 (6%)
Query: 274 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPL-- 331
E + ++E + + +E D E+ + E + EK+ + E K++ + +
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 332 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 391
E E K D EE KM ++ + +E++ E E + +QE+ + K +
Sbjct: 539 EKKTQEQEKKTWDQEE--KMREEERMREREKKMREEEE-----MMREQEEKMQEQEEKMR 591
Query: 392 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 451
+Q+ ++ E E+ + K + + MQ ++E + E K + + ++
Sbjct: 592 EQEEK--MWEQEEKMQEQ--EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Query: 452 KLKNQNKNKENQELKQEKEGK 472
+ + K +E +E +E+E K
Sbjct: 648 MWEQEEKMREQEEKMREQEEK 668
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 103 bits (256), Expect = 2e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 145 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 204
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
Query: 205 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 264
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
Query: 265 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 316
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
Query: 317 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 359
L + +K L A + KD D +E ++D D ++
Sbjct: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
Query: 360 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 419
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
Query: 420 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 479
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
Query: 480 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 539
++KT+ S + + +S ++ +P S G + S K
Sbjct: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
Query: 540 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 598
T T +SP E + P R ++ + + + K +K EK
Sbjct: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
Query: 599 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 658
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
Query: 659 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 718
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
Query: 719 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 771
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
Query: 772 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 831
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
Query: 832 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 891
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
Query: 892 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 924
K+++ E + + S ++ S S
Sbjct: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
Query: 925 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
Query: 985 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1040
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
Query: 1041 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
Query: 1095 LKIKDKEKTKHTPTESKNK 1113
++ +++ + +E + +
Sbjct: 982 MEKRERRALERRISEMEEE 1000
Score = 45.4 bits (106), Expect = 6e-04
Identities = 161/855 (18%), Positives = 303/855 (35%), Gaps = 151/855 (17%)
Query: 9 PIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
P+ ++ D+N +K + K I +IE + K +E+ K + S
Sbjct: 300 PLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDE----SSC 355
Query: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPD 128
S E+ + D+E E E KTK A + S Q A + T +S
Sbjct: 356 SSEEDEEDDSESEA-ETDKTKPLASVTNANTSS----------TQAAPVAVTTPTVSSGQ 404
Query: 129 STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR-GDVKQVKELISLGAN 187
+TP P KK P+++++ K +R + + + G + E+ +
Sbjct: 405 ATPTSPI------KKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG 458
Query: 188 VNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
KD AG T +A + + LD+ DS + + +
Sbjct: 459 QKEKDTAGVTR-----------------SASSPRLSSSLDNKEKEKDSKGTRLAYVAPTI 501
Query: 248 LRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT------DSEEAQSVNP 301
P +A T ++E R+ SYT D ++ SVN
Sbjct: 502 ----------------PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 545
Query: 302 -SSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
S+ ++ +D LI S +PS T P+ + + + +
Sbjct: 546 GSTYHKSCSFGRRQDDLISSS---VPSTTSTPTVTSAAGLQ----KSLLSSTSTTTKITT 598
Query: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
+ L+A+ + K K P+ V + A ++T+
Sbjct: 599 GSSSAGTQSSTSNRLWAED------STEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTT 652
Query: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
+ ++ + ++ Y+ ++ + + + ++++ ++ ++ +G T +
Sbjct: 653 AGTVSSTTEVRERRRSYLTPVRDEES-----ESQRKARSRQARQSRRSTQGVTLTDLQEA 707
Query: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
G S +TRE+ N K K EKQ KQE
Sbjct: 708 EKTIGRSRSTRTREQENEEKEKEEK-----------------------EKQDKE-KQEEK 743
Query: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
K + E Q YD T + P S+S + S S+
Sbjct: 744 KESETSREDEYK-QKYSRTYDETYQRYRPVSTSSSTTPSSSLST----------MSSSLY 792
Query: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
+ + P NS + G T K ERE EK ++E EGE +K + K S +
Sbjct: 793 ASSQLNRP---NSLVGITSAYSRGIT------KENEREGEKREEEKEGE-DKSQPK-SIR 841
Query: 661 ELQRSVEFDR----EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEK 716
E +R E R FW ++ SDE E E +S T E +K K T+
Sbjct: 842 ERRRPREKRRSTGVSFWTQD---SDENE-----QEQQSDTEEGSNK--------KETQTD 885
Query: 717 HVSK-ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL--GMSAIEES 773
+S+ E + D+ +S +++ K + D ++F L + A E
Sbjct: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEK 945
Query: 774 IGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 833
+ L + +++ + ++++ ++ E+ + ++EK ER+ E++I + K
Sbjct: 946 LKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRAL--ERRISEMEEELKM 1003
Query: 834 KLDLSECVDKIKEKD 848
DL ++K+++
Sbjct: 1004 LPDLKADNQRLKDEN 1018
Score = 40.4 bits (93), Expect = 0.018
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 836 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 895
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
Query: 896 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
Query: 954 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 999
SS A +S + T P+K KE+++KD+
Sbjct: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
Query: 1000 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1047
+I KE K KD + A P+ SS +K+ K
Sbjct: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
Query: 1048 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1107
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
Query: 1108 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1164
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
Query: 1165 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1217
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
Query: 1218 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1277
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
Query: 1278 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1336
R T + + E KQ + EE + +TS + + +S +
Sbjct: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
Query: 1337 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1364
+ +S +T+P+ + S+S Y S+ N
Sbjct: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
Score = 37.4 bits (85), Expect = 0.15
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 748
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
Query: 749 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
E E T + T+ S+ + + + + + P S IK+
Sbjct: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
Query: 809 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 867
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
Query: 868 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 918
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
Query: 919 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 955
S S +G K +++ S+ +T++ +
Sbjct: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
Query: 956 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 998
Q+ SS K + + + L D EK+K
Sbjct: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Query: 999 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1043
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
Query: 1044 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1101
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
Query: 1102 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1161
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
Query: 1162 SLNRSPRSENEKPG 1175
+ +R ENE+ G
Sbjct: 809 AYSRGITKENEREG 822
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 103 bits (256), Expect = 2e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 145 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 204
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
Query: 205 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 264
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
Query: 265 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 316
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
Query: 317 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 359
L + +K L A + KD D +E ++D D ++
Sbjct: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
Query: 360 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 419
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
Query: 420 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 479
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
Query: 480 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 539
++KT+ S + + +S ++ +P S G + S K
Sbjct: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
Query: 540 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 598
T T +SP E + P R ++ + + + K +K EK
Sbjct: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
Query: 599 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 658
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
Query: 659 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 718
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
Query: 719 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 771
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
Query: 772 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 831
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
Query: 832 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 891
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
Query: 892 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 924
K+++ E + + S ++ S S
Sbjct: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
Query: 925 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
Query: 985 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1040
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
Query: 1041 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
Query: 1095 LKIKDKEKTKHTPTESKNK 1113
++ +++ + +E + +
Sbjct: 982 MEKRERRALERRISEMEEE 1000
Score = 45.4 bits (106), Expect = 6e-04
Identities = 161/855 (18%), Positives = 303/855 (35%), Gaps = 151/855 (17%)
Query: 9 PIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
P+ ++ D+N +K + K I +IE + K +E+ K + S
Sbjct: 300 PLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDE----SSC 355
Query: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPD 128
S E+ + D+E E E KTK A + S Q A + T +S
Sbjct: 356 SSEEDEEDDSESEA-ETDKTKPLASVTNANTSS----------TQAAPVAVTTPTVSSGQ 404
Query: 129 STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR-GDVKQVKELISLGAN 187
+TP P KK P+++++ K +R + + + G + E+ +
Sbjct: 405 ATPTSPI------KKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEG 458
Query: 188 VNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
KD AG T +A + + LD+ DS + + +
Sbjct: 459 QKEKDTAGVTR-----------------SASSPRLSSSLDNKEKEKDSKGTRLAYVAPTI 501
Query: 248 LRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT------DSEEAQSVNP 301
P +A T ++E R+ SYT D ++ SVN
Sbjct: 502 ----------------PRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNE 545
Query: 302 -SSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
S+ ++ +D LI S +PS T P+ + + + +
Sbjct: 546 GSTYHKSCSFGRRQDDLISSS---VPSTTSTPTVTSAAGLQ----KSLLSSTSTTTKITT 598
Query: 361 EQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSC 420
+ L+A+ + K K P+ V + A ++T+
Sbjct: 599 GSSSAGTQSSTSNRLWAED------STEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTT 652
Query: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
+ ++ + ++ Y+ ++ + + + ++++ ++ ++ +G T +
Sbjct: 653 AGTVSSTTEVRERRRSYLTPVRDEES-----ESQRKARSRQARQSRRSTQGVTLTDLQEA 707
Query: 481 TVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT 540
G S +TRE+ N K K EKQ KQE
Sbjct: 708 EKTIGRSRSTRTREQENEEKEKEEK-----------------------EKQDKE-KQEEK 743
Query: 541 KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAK 600
K + E Q YD T + P S+S + S S+
Sbjct: 744 KESETSREDEYK-QKYSRTYDETYQRYRPVSTSSSTTPSSSLST----------MSSSLY 792
Query: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
+ + P NS + G T K ERE EK ++E EGE +K + K S +
Sbjct: 793 ASSQLNRP---NSLVGITSAYSRGIT------KENEREGEKREEEKEGE-DKSQPK-SIR 841
Query: 661 ELQRSVEFDR----EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEK 716
E +R E R FW ++ SDE E E +S T E +K K T+
Sbjct: 842 ERRRPREKRRSTGVSFWTQD---SDENE-----QEQQSDTEEGSNK--------KETQTD 885
Query: 717 HVSK-ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL--GMSAIEES 773
+S+ E + D+ +S +++ K + D ++F L + A E
Sbjct: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEK 945
Query: 774 IGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 833
+ L + +++ + ++++ ++ E+ + ++EK ER+ E++I + K
Sbjct: 946 LKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRAL--ERRISEMEEELKM 1003
Query: 834 KLDLSECVDKIKEKD 848
DL ++K+++
Sbjct: 1004 LPDLKADNQRLKDEN 1018
Score = 40.4 bits (93), Expect = 0.018
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 836 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 895
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
Query: 896 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
Query: 954 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 999
SS A +S + T P+K KE+++KD+
Sbjct: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
Query: 1000 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1047
+I KE K KD + A P+ SS +K+ K
Sbjct: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
Query: 1048 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1107
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
Query: 1108 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1164
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
Query: 1165 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1217
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
Query: 1218 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1277
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
Query: 1278 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1336
R T + + E KQ + EE + +TS + + +S +
Sbjct: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
Query: 1337 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1364
+ +S +T+P+ + S+S Y S+ N
Sbjct: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
Score = 37.4 bits (85), Expect = 0.15
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 748
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
Query: 749 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
E E T + T+ S+ + + + + + P S IK+
Sbjct: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
Query: 809 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 867
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
Query: 868 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 918
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
Query: 919 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 955
S S +G K +++ S+ +T++ +
Sbjct: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
Query: 956 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 998
Q+ SS K + + + L D EK+K
Sbjct: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Query: 999 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1043
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
Query: 1044 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1101
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
Query: 1102 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1161
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
Query: 1162 SLNRSPRSENEKPG 1175
+ +R ENE+ G
Sbjct: 809 AYSRGITKENEREG 822
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 103 bits (256), Expect = 2e-21
Identities = 48/123 (39%), Positives = 76/123 (61%), Gaps = 3/123 (2%)
Query: 150 RQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYD 209
R+ K N+RN+ GET LH A I G +++V++L+ G +N +D+ GWTPLHEACN G+ +
Sbjct: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
Query: 210 VAKILIAAGA---DVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVD 266
+ + L+ GA D QG + TPLHD+ + GH ++ +LLL G + + G P++
Sbjct: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Query: 267 VAE 269
+
Sbjct: 637 TLQ 639
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 102 bits (255), Expect = 3e-21
Identities = 62/175 (35%), Positives = 97/175 (55%), Gaps = 7/175 (4%)
Query: 118 MQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQ---KDKVNKRNERGE--TPLHMAAIR 172
+Q +++P T + + A K + +Q VN R+ G TPLH AA
Sbjct: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694
Query: 173 GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 232
V V+ L+ GA+V+ KD G PLH AC+ G+Y+VA++L+ GA VN L TPL
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754
Query: 233 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLKREVPLSD 285
H++A+ G +I KLLL+HG +P + N+ G P+D+ + + ++ LL+ + L D
Sbjct: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLD 809
Score = 99.4 bits (246), Expect = 3e-20
Identities = 53/120 (44%), Positives = 72/120 (60%)
Query: 161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
R TPLH+AA V+ V+ L+ GA+V+ KD G PLH AC+ G+Y+V ++L+ GA
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 221 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 280
VN L TPLH++AS ++ LLL HG +P N HG+ VD+A T EL L E
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
Score = 90.5 bits (223), Expect = 2e-17
Identities = 53/170 (31%), Positives = 89/170 (52%), Gaps = 5/170 (2%)
Query: 153 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 210
+ +N R+ +G TPLH+AA +++ + L+ GA+VN +D G PLH A + G+ D+
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885
Query: 211 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 270
A +LI VN TPLH++A G + LLL HG +P N+ G+ P+D+A
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Query: 271 EELELLLKREVP---LSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSL 317
+++ LL +P L + A ++P+S + + + D+L
Sbjct: 946 DDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNL 995
Score = 85.9 bits (211), Expect = 4e-16
Identities = 43/109 (39%), Positives = 66/109 (60%)
Query: 161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
R +PLH AA G V+ L+ +GANV+ +D G PLH AC+ G+ +V +L+ GAD
Sbjct: 215 RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD 274
Query: 221 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 269
N + + TPLH++A G D+ +LL+HG +P N G+ +D+A+
Sbjct: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Score = 64.7 bits (156), Expect = 9e-10
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 4/158 (2%)
Query: 157 KRNERGETPLH--MAAIRGDVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 213
K+ + ET LH +A++ KQV EL+ GANVN K+ TPLH A + DV ++
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
Query: 214 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 273
L GA +N T LH +A +GH +LLL +G +P + G + E +
Sbjct: 577 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG-NEAV 635
Query: 274 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSE 311
+ +L P+ D Y E +++ + +V + S+
Sbjct: 636 QQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673
Score = 56.6 bits (135), Expect = 2e-07
Identities = 84/342 (24%), Positives = 131/342 (38%), Gaps = 75/342 (21%)
Query: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
V+ R++ G PLH A G + V L+ GA+ N +D +TPLHEA G DV +L
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 215 IAAGADVNTQGLDDDTPLH--------------------DSASSGHRD------------ 242
+ GAD N + D + L ++A SG+ +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361
Query: 243 ----------------------IVKLLLRHGGNPFQANKHGERPVDVA----ETEELELL 276
IV+LLL+HG + +K G P+ A E ELL
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
Query: 277 LKREVPLSDDD-ESYTDSEEAQSVNPSSVDENIDSETEKDSLI-CESKQILPSKTPLPSA 334
LK ++ D +T EA S N V + S +L+ C K + P P
Sbjct: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV-DMAPTPEL 480
Query: 335 LDE--YEFKDDDDEEINKMID---DRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFK 389
+ YEFK + + D + L E +P++ +T L + +PK
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC-AVASLHPK--- 536
Query: 390 SKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDM 431
+KQ +L ++ +NK T V E +++D+
Sbjct: 537 -RKQVTELLLRKGANVNE----KNKDFMTPLHVAAERAHNDV 573
Score = 50.8 bits (120), Expect = 1e-05
Identities = 36/136 (26%), Positives = 65/136 (47%), Gaps = 6/136 (4%)
Query: 139 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 198
P +K+ R+ VN++N+ TPLH+AA R ++ L GA +N D G T
Sbjct: 535 PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Query: 199 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQAN 258
LH A G+ ++L++ G+D + L T +A G+ + ++L P + +
Sbjct: 595 LHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSE--STPIRTS 648
Query: 259 KHGERPVDVAETEELE 274
R ++ ++ +LE
Sbjct: 649 DVDYRLLEASKAGDLE 664
Score = 39.3 bits (90), Expect = 0.040
Identities = 51/196 (26%), Positives = 76/196 (38%), Gaps = 55/196 (28%)
Query: 124 DNSPDST--PNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGE--------TPLHMAAIR- 172
+NSP S+ P S ++P+ + + S + V+ G P A+R
Sbjct: 126 NNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRE 185
Query: 173 -------GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 225
GDV +VK L+ ANVN KD AG
Sbjct: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAG------------------------------ 214
Query: 226 LDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA----ETEELELLLKREV 281
+PLH +A G +D+V+ LL+ G N + G P+ A E + LLL +
Sbjct: 215 -RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA 273
Query: 282 -PLSDDDESYTDSEEA 296
P + D+ +YT EA
Sbjct: 274 DPNARDNWNYTPLHEA 289
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 102 bits (254), Expect = 4e-21
Identities = 89/418 (21%), Positives = 201/418 (48%), Gaps = 52/418 (12%)
Query: 621 DKEGKTLKKHKLKHKEREKEK--------HKKEIEGEKEKYKTKDSAKELQRSVEFDREF 672
D +G ++++ K +ER +EK K+E EK++++ +D +E QR E +RE
Sbjct: 48 DADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE- 106
Query: 673 WKENFFKSDETEDLFLNMEHESLTLEKKSKLE---------------KNIKDDKSTKEKH 717
++ + D + N + E E++++ E + +D + +E+
Sbjct: 107 -RQTDRERDRQREKERNRQKER---ERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 718 VSKERNFKEERDKIK-KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGL 776
+ER + ER++ K +E EK+ +E + ++ + E+EN D+ SE G E
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE---RGRERERER--- 216
Query: 777 HLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLD 836
E E + E++ + +E +++ K + +EK E+ E E+ + E + ++D+
Sbjct: 217 ---ETETETERKRQTDRE-RDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 837 LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKE 896
++ ++ D+ TE+ + K + ++ +R + RE+ +R+ ++E+ E++
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER-ERERERER-ERQ 330
Query: 897 RHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHI 955
R +EK K+ +Q++ + G+ + E ++ +E+ RD++S ++
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS-----ARER 385
Query: 956 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDK 1013
+E ++ D K + + EK +D +T +E++ KD++ +R +ER + ++K
Sbjct: 386 EERERDRDRDRQKERERQ----TEKDRDGQRETEKQRERE-KDRESERGRERGREREK 438
Score = 84.7 bits (208), Expect = 8e-16
Identities = 81/354 (22%), Positives = 177/354 (50%), Gaps = 59/354 (16%)
Query: 618 KKMDKEG-KTLKKHKLKHKEREK---EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 673
++ D+E + ++++ K +EREK E+ ++E + EKE KT+D E R E +RE
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN-KTEDRHSERGRERERERETE 219
Query: 674 KENFFK--SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKI 731
E K +D D E E EK+++ E+ + ++ ++K +ER+ +RD+
Sbjct: 220 TETERKRQTDRERDRQRKTERER---EKQAERER-ASERETERDKERERERDRDRDRDRR 275
Query: 732 KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 791
+KE E+ D K +R T++D E E++ + +++ +
Sbjct: 276 QKERERQ------TDRKRQRR---TERDRE-----------------TERKRERQRERER 309
Query: 792 IKESKEKPEK-RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL 850
+E K E+ R + +E++ ++ + EKE++ K + ++E D+ ++ ++ +
Sbjct: 310 ERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR-------ERNRQTGRE 362
Query: 851 YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP-EKERHLAESKEKHLME 909
E+ +E E+ + DR+ +RE+ +R+ D+++ +KER K++
Sbjct: 363 GRRQAER-ERERERER---------DRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 910 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963
+ KQ + + +SE+G+ + ++RE K+K R+++ T+ + ++ K+S++
Sbjct: 413 ETEKQREREKDRESERGRERGRERE---KQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 60.1 bits (144), Expect = 2e-08
Identities = 53/279 (18%), Positives = 123/279 (44%), Gaps = 40/279 (14%)
Query: 875 DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 934
DDRE++R+K +R+ +EK + ER +E+ + EK +++++DR
Sbjct: 52 DDRERNRQK-ERERRREKRQTERETDRKRER----------------RREKDRHRKRDRH 94
Query: 935 LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK 994
+E+ RD+E + ++ ++ + K + + E+ +D + DG+ +
Sbjct: 95 ---RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRD---RQTDGQRE 148
Query: 995 DKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQ 1054
++ +D ++ +ER +++ Q + + E ++ K + ++ + +++ D +
Sbjct: 149 RERQRDAEKERERQTDRER-QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 1055 TSFERMLSLK-----------DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1103
ER + D E ++ K +E+ KQ E+ER R K +++E+
Sbjct: 208 RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERD 267
Query: 1104 KHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1142
+ + + KE R TD + + +D + R +
Sbjct: 268 RDRDRDRRQKERERQ-----TDRKRQRRTERDRETERKR 301
Score = 57.0 bits (136), Expect = 2e-07
Identities = 71/392 (18%), Positives = 161/392 (41%), Gaps = 41/392 (10%)
Query: 444 KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCS-----EKTREEGNF 498
+Q+ + K + + ++ ++ Q K+ KE R T G D E+ R+
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 499 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 558
++ D + K + E++ +Q + SE + +
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREKNRQERRERE-RQREKENKTEDRHSERGRERERE 215
Query: 559 RYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK 618
R TE+E ++ + + K + + +K E + + E + D +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 619 KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFF 678
+ ++E +T +K + + + + + K+E + E+E+ + ++ +E +R E +RE
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE------- 328
Query: 679 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK-----EKHVSKERNFKEERDKIKK 733
+ ETE + E E E+K K + + +++ + + +ER + ERD+
Sbjct: 329 RQRETE---RDREKER---ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSA 382
Query: 734 ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIK 793
+ ++ +D ++ERE T+KD + G EK+ + EK ++ +
Sbjct: 383 REREERERDRDRDRQKERER-QTEKDRD-------------GQRETEKQREREK-DRESE 427
Query: 794 ESKEKPEKRSQIK--EKDIEKMERKTFEKEKK 823
+E+ +R + K E+D E+ + +++K
Sbjct: 428 RGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 48.9 bits (115), Expect = 5e-05
Identities = 52/289 (17%), Positives = 121/289 (41%), Gaps = 53/289 (18%)
Query: 886 RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 945
R +E P + K+ +++ + E + ++ +E DR K+E+ R+K+
Sbjct: 30 RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDR---KRERRREKD 86
Query: 946 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK 1005
+H K +E+ +D + + + + +++D R K
Sbjct: 87 ------------------------RHRKRDRHRERQRD---REKERERQTDRERDRQREK 119
Query: 1006 ERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1065
ER++ K++ + + + E ++ + + + ++ R +++ + QT ER
Sbjct: 120 ERNRQKERER-----ETEREGERGRDRQTDGQRE-RERQRDAEKERERQTDRER------ 167
Query: 1066 LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE-VT 1124
++ E+ +QKE+ER +NR E + +++++ K TE ++ E R + E T
Sbjct: 168 -------QRQTERNRQKEREREKNRQ--ERRERERQREKENKTEDRHSERGRERERERET 218
Query: 1125 DAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1173
+ T+ K+ D +R + + + + S+ R E E+
Sbjct: 219 ETETERKRQTDRERDRQRKTEREREKQAERER-ASERETERDKERERER 266
Score = 32.7 bits (73), Expect = 3.7
Identities = 35/148 (23%), Positives = 59/148 (39%), Gaps = 17/148 (11%)
Query: 28 RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKK 87
R +D+ + + ER + +E K +R+ R ERD + E+E K++
Sbjct: 290 RTERDRETERKRERQRER-ERERERNRKRERERERERERERQRETERDREKERERKRKRQ 348
Query: 88 TKKEAGNKKSTPVSILFGYPLSER---------KQMALLMQMTARDNSPDSTPNHPSQT- 137
T+ + + T G +ER +Q A + RD D QT
Sbjct: 349 TEMDRERNRQTGRE---GRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405
Query: 138 --TPAQKKTPSSSSRQKDKVNKR-NERG 162
Q++T R+KD+ ++R ERG
Sbjct: 406 KDRDGQRETEKQREREKDRESERGRERG 433
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 102 bits (254), Expect = 4e-21
Identities = 154/868 (17%), Positives = 381/868 (43%), Gaps = 91/868 (10%)
Query: 274 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQI-LPSKTPLP 332
E L ++ + +E + E+ QS +E D E + + E ++ K
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 333 SALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKK 392
+ F++++++E K +LRKE+ K E E ++ ++E+ + +
Sbjct: 231 RERQDRVFQEEEEKEWRKR---ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 393 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK 452
++ E+ L+ K+ E + Q ++ +Q+ + +++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQ---------EEERREQQEERREQQERREQQEERREQQ 338
Query: 453 LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHL 512
L+ + + + Q+L++E+E E R L E+ R E R+ + + L
Sbjct: 339 LRREQEERREQQLRREQE--EERREQQLRRE-----QEEERREQQLRREQQLRREQQL-- 389
Query: 513 FHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESS 572
+ L +Q +Q+ + ++ + L R E
Sbjct: 390 ---------RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH------ 434
Query: 573 SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKL 632
KH+++ + Q+ + + K ++E E LK+ +E + + KL
Sbjct: 435 ---EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 633 KHKEREKEKHKKE-------IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 685
+ +ER +++ ++E E +++ K ++ + LQ+ + +++ +E +E +
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE----QEERRE 547
Query: 686 LFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK 745
L E E LE++ + ++ ++ + +++ + +E +++R +K+E E+ E+++K
Sbjct: 548 QLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQR--LKREQEERL-EQRLK 603
Query: 746 DLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI 805
+EE E + ++ E L EE L++ E E++++ ++ +E+ E+R Q
Sbjct: 604 --REEVERLEQEERRE-QRLKREEPEEERRQQLLKSEEQEERRQQQLR--REQQERREQR 658
Query: 806 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE-----CVDKIKEKDKLYSHHTEKCHK 860
+++ E+ ER E+++K EH+ E+ + +L+E ++IK + + E
Sbjct: 659 LKRE-EEEER----LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES-EA 712
Query: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 920
+ +SK + +K +E R + +++ + + E E E + H +++ +Q + +
Sbjct: 713 DARQSKVYSRPRK---QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 921 -----SKSEKGKNKEKDRE--LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 973
KSE+G+ + R +++E+ E + + EE++ + + EK
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829
Query: 974 PLSLKEKTKDEPLKTPD-----GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1028
L E ++E L+ + +E+D +D +R + +++ +D+ + L+ + + +
Sbjct: 830 ELQFLE--EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ-KWRWQLEEERKRRR 886
Query: 1029 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLR 1088
+ PA ++ KE++L+ ++ + E + E E+ +++ +E+++Q+E++ LR
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLR 945
Query: 1089 -NRNCLELKIKDKEKTKHTPTESKNKEL 1115
R + ++++ K + K ++L
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQL 973
Score = 99.0 bits (245), Expect = 4e-20
Identities = 147/896 (16%), Positives = 388/896 (43%), Gaps = 138/896 (15%)
Query: 271 EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 330
+E E + E L ++E E + + ++ + ++ + + ++ L + P
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRR-----QELERQYREEEEVQQEEEQLLREEP 1158
Query: 331 LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKS 390
E E + ++EE+ + ++ +LR+EQ K + E+ + ++E+ K +
Sbjct: 1159 EKRRRQELERQYREEEELQQ--EEEQLLREEQEKRRQ---ERERQYREEEELQRQKRKQR 1213
Query: 391 KKQKPSRV-LYSSTESSDEEALQNKKI------STSCSVIPETSNSDMQTKKEYV-VSGE 442
+ + R L E E A+++ K+ + + ++ D Q++++ + GE
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 443 HKQKGKVKRKLKNQNKNK-----ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGN 497
+++ + + + + Q +++ E E +++KE K R + + E+ R
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 498 FRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQ--- 554
+ F ++ L E++ PL+++ Q
Sbjct: 1334 TDRKFREEEQL------------------LQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 555 ----PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF 610
+R E +FL E ++ C+ +E+ Q D +F E+ ++ ++ F
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLR-CQEREQQLRQ-DRDRKFREEEQ-QLSRQERDRKF 1432
Query: 611 ENSDCTLKKMDKEGKTLKKHKLKHKEREK----------EKHKKEIEGEKEKYKTKDSAK 660
+ +++ ++E K L++ + +ER + E+ ++++ ++ K + +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 661 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
+L+R E DR+F +E +S E E FL E + L ++ + K +++++ + + +
Sbjct: 1493 QLRRQ-ERDRKF-REQELRSQEPERKFLEEEQQ---LHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
+R +++RD+ +E EE+++ +EE++ ++D +F L E
Sbjct: 1548 QR--RQDRDRKFRE------EEQLRQEREEQQLSRQERDRKF--------------RLEE 1585
Query: 781 KEIDIEKQEKHIKESKE---KPEKRSQIK-EKDIEKMERKTFEKEKKIKHEHKSEKDKLD 836
+++ ++QE+ E ++ + E + Q++ E+D + E + +E++ + H+ E+D+
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 837 LSECVD-KIKEKDKLYSH-------HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 888
L E + +E+++ H E+ +EGE +++ R++ DRK
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE------------EQQLRRQERDRKF 1693
Query: 889 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 948
+E+ + R E K ++ +Q ++ + E+ + + + +L ++E+ R
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR-----K 1748
Query: 949 ITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD 1008
I + ++ E++ L+ + +D + + ++++++ + R +E D
Sbjct: 1749 ILEEEQLRPEREEQ-------------QLRRQERDRKFREEEQLRQEREEQQL-RSQESD 1794
Query: 1009 KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD--LMQTSFERMLSLKDL 1066
+ K + L+ + E + +P+ ++ +L + L Q + + +
Sbjct: 1795 R---KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 1067 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1122
++ ++ ++++ Q+E+++ R E K++++ + E +++++ KS E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQER--ERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 98.6 bits (244), Expect = 6e-20
Identities = 149/782 (19%), Positives = 336/782 (42%), Gaps = 76/782 (9%)
Query: 256 QANKHGERPVDVAETEELELLLKREVPLSDDDES----YTDSEEAQSVNPSSV----DEN 307
Q + ER E EEL+ +++ +D S + E+ +V + V EN
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 308 IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ-RKEN 366
+DS + + + S+ L L E + +D + E DRH +EQ +E
Sbjct: 1248 EQFRQLEDSQLRDRQ----SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 367 EPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPET 426
+ EA++ +++EK + + K+++ + + +EE L ++
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQE----TDRKFREEEQLLQEREEQPL----RR 1355
Query: 427 SNSDMQTKKEYVVSGEHKQKGK--VKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 484
D + ++E + H+++G+ ++ + + + + +E + LK+E++ + R L
Sbjct: 1356 QERDRKFREEEL---RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-- 1410
Query: 485 GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 544
D K REE ++ + D + + L E+Q L+QE +
Sbjct: 1411 --DRDRKFREEE--QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ--LRQERHRKFR 1464
Query: 545 SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 604
+ + + +FL E ++ + K + Q+ ++ +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE-------------LRSQ 1511
Query: 605 DHSPTFENSDCTLKKMDKEGKTLKKHK-LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ 663
+ F + L + ++ K L++ + L+ +ER +++ + +E+ + + +E Q
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 664 RS-VEFDREF-WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 721
S E DR+F +E + E E F+ E + E + +L + +D K +++ + +E
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE-RDRKFREDEQLLQE 1630
Query: 722 RNFKEERDKIKKESEKSFREEKIKDLKEEREN-IPTDKDSEFTSLGMSAIEESIGLHLVE 780
R EE+ ++E ++ F EE+ + ++ERE + D+D +F E L
Sbjct: 1631 R---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF--------REEEQLLQEG 1679
Query: 781 KEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHK----SEKDK 834
+E + +QE+ K +E+ + R Q +E+ E+ + + E E+K + E + +E+++
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 835 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 894
L E KI E+++L E+ + E+ + ++ + ++ ++ D++ E
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 895 KERHLAESKEKHLMEKKNK-----QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINI 949
+E+ E +E+ L ++ + + + + E+ +E+DR+ +E+ +E
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 950 TNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK 1009
+ QEE++ + + E+ ++ + K+E G+ K ++ K R E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREE--HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGT 1917
Query: 1010 HK 1011
H+
Sbjct: 1918 HQ 1919
Score = 97.1 bits (240), Expect = 2e-19
Identities = 154/892 (17%), Positives = 374/892 (41%), Gaps = 95/892 (10%)
Query: 269 ETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSK 328
+ E E LKRE P + + SEE + + E+ E ++ L +
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 329 TPLPSALD--EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPK 386
+ E E +++ E+ + I R I + + + E+E +A ++ ++++ K +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSR-IPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 387 SFKSKKQKPSRVLYSSTESSDEEA-LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 445
+ +++K R +E A Q ++ + + + +S
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 446 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 505
+ + +R+L+ + + + Q E+E KE R L E+ + ++ +
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 506 DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSE---------MSLQPD 556
++ GL E Q QE + E + +P
Sbjct: 851 EEED----------------GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 557 LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 616
L E + L E + +EK + Q+ E + +++ E+ E +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQ---ERQYREEEQLQQEEEQLLREERE-K 950
Query: 617 LKKMDKEGKTLKKHKLKHKERE---KEKHKKEIEGEKEKYKTKDSAKELQRSVEFD---- 669
++ ++E + K KL+ KE + +E K+ + ++KY+ ++ ++ + + +
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 670 --REFWKENFFKSDETEDLFLNMEHESLTLEKKSK--LEKNIKDDKSTKEKHVSKERNFK 725
R+ W+ + K DE L E E L E++ K L++ + + +E +E+
Sbjct: 1011 RRRQEWERQYRKKDE-----LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 726 EERD-KIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSA-IEESIGLHLVEKEI 783
EER+ + ++E E+ +R+E+ +L++E E + ++ + E L E+++
Sbjct: 1066 EERETRRRQELERQYRKEE--ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 784 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 843
E++EK ++ E+ + + +++ E++ R+ EK ++ + E + +++ +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-------EL 1176
Query: 844 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 903
+E+++L EK +E E+ + + E++ R+ K++ E ++ K
Sbjct: 1177 QQEEEQLLREEQEKRRQERER------------QYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 904 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963
+ EK+N DN Y KG+ E+ R+L+ + RD++S + +H+ E++
Sbjct: 1225 WQWEPEKENAVRDNKVYC---KGRENEQFRQLEDSQ-LRDRQSQQ--DLQHLLGEQQ--- 1275
Query: 964 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1023
+ + ++ +++ + P + +E+ K+ K DR + +K LL+ +
Sbjct: 1276 ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK--------QLLREE 1324
Query: 1024 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKK---HKEKIK 1080
E + + ++ ++ + L + +R ++L ++ +K +++++
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 1081 QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1132
++E+ER + +L+ +++E+ + K +E + S + D +E++
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Score = 96.7 bits (239), Expect = 2e-19
Identities = 112/557 (20%), Positives = 259/557 (46%), Gaps = 66/557 (11%)
Query: 602 KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKE 661
+ E+ FE D L E + ++ + K +E+E+E + E + EK++ + +
Sbjct: 114 RQEEDQRRFEPRDRQL-----EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 662 LQRSVEFDREFWKENFFKSDETEDLFLNMEHES------LTLEKKSKLEKNIKD-DKSTK 714
+ R+ W+E + E E L HE+ L ++ LE K ++ +
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 715 EKHVSKERNFKEERDK--------IKKESEKSFREE--KIKDLKEERENIPTDKDSEFTS 764
++ ++R F+EE +K ++KE EK EE + ++L+EE E + + E
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL---RKLERQE 285
Query: 765 LGMSAIEESIGLHLVEKEIDI-----EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 819
L EE + +E + E++ + +E +E+ E+R Q +E+ +++ R+ E
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 820 -KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH---HTEKCHKEGEKSKNTAAIKKTD 875
+E++++ E + E+ + L ++ + + +L E+ + ++ + +++
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 876 ----------DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 925
+++ RE+ R+ +E+ +++H E +E+ L K +Q + ++ K E+
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL---KREQEERRDWLKREE 462
Query: 926 GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 985
+ + ++E K++ RD+E ++EE++ + + Q + +E+ +++
Sbjct: 463 -ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE---QEERREQR 518
Query: 986 LKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1045
LK + +E+ ++ ++ R++ + + Q+ LK E +K + + R +E+
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQL-----LKREEEKRLEQERREQRLKREQEE 573
Query: 1046 RLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1105
R D L++ ER E E+ + ++++K++E ERL E ++K +E
Sbjct: 574 R--RDQLLKREEERRQQRLKREQEE---RLEQRLKREEVERLEQEERREQRLKREE---- 624
Query: 1106 TPTESKNKELTRSKSSE 1122
P E + ++L +S+ E
Sbjct: 625 -PEEERRQQLLKSEEQE 640
Score = 95.9 bits (237), Expect = 4e-19
Identities = 144/906 (15%), Positives = 373/906 (41%), Gaps = 133/906 (14%)
Query: 269 ETEELELLLKREVPLSDDDESYTDSEEA---QSVNPSSVDENIDSETEKDSLICESKQIL 325
+ E E L+RE + + + EE Q + +E + + ++ + +Q+
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 326 PSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 385
+ E + + + + + LR+EQ+ E E E+ +QE+
Sbjct: 391 REQ----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER---- 442
Query: 386 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 445
+ + K+++ R + E ET + + +K+ + + ++
Sbjct: 443 REQRLKREQEERRDWLKREE-------------------ETERHEQERRKQQLKRDQEEE 483
Query: 446 KG----KVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKS 501
+ K++ + + + + + Q+L++E+E + R+ L ++ R E R+
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ--QRLRSEQQLRRE 541
Query: 502 FSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 561
+ + L ++ L+QE + L E Q L R +
Sbjct: 542 QEERREQLL-----------------KREEEKRLEQERREQRLKREQEERRDQL-LKREE 583
Query: 562 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 621
+ L + +++ K ++ LE E+ ++K E+ P E LK +
Sbjct: 584 ERRQQRLKREQEERL---EQRLKREEVERLEQEERREQRLKREE--PEEERRQQLLKSEE 638
Query: 622 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 681
+E + ++ + + +ER +++ K+E E E+ + + K +E +R E E
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE---------- 688
Query: 682 ETEDLFLNMEHESLTLEKKSKLEKNIKDDK--STKEKHVSKERNFKEERDKIKKESEKSF 739
E E ++ + + + E + + K S K + R ++E + ++ESE +
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 740 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 799
+EE+ +++ E ++ +FT + + G + + +Q + ++E+
Sbjct: 749 QEEERAHRQQQEE----EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 800 EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 859
++ + ++ EK +R+ +E++ + + E+++L E +++E++ E+
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 860 KEGEKSKNTAAIKKTDDREKSREKMDRKHD-KEKPEKERHLAESKEKHLMEKKNKQSDNS 918
+ ++ + ++R++ R + K +E+ KE+ L + +E+ L ++
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE------- 917
Query: 919 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 978
+EK R +++ + R++E + + ++EE++ + Q+ K L+
Sbjct: 918 ----------REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 979 EKTKDEPLKTPDGKEKDKKDKDIDRYKERD--------------------------KHKD 1012
+K + + P+ + + +++K +Y+E + + KD
Sbjct: 968 QKEEQLLGEEPEKRRRQEREK---KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 1013 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1072
++Q L+ E +K + + ++ + +E+ + + Q E + + E+E+ +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQ----ERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080
Query: 1073 KKHKEKIKQKEKERL------RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1126
+K +E+++Q+E++ L R R E + +++E+ + + +E + + E+
Sbjct: 1081 RK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139
Query: 1127 YTKEKQ 1132
Y +E++
Sbjct: 1140 YREEEE 1145
Score = 79.0 bits (193), Expect = 5e-14
Identities = 83/515 (16%), Positives = 231/515 (44%), Gaps = 53/515 (10%)
Query: 647 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 706
E ++ + K+S + +R E R F E D L E +K+ + E+
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRF---------EPRDRQLEEEPGQRRRQKRQEQERE 147
Query: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER-ENIPTDKDSEFTSL 765
+ + + EK E+ ++ RD+ + ++E + + +EE+ ++ + EF
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 766 GMSAIEESIGLHLV-EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI 824
E + L +E +++E+ + +E+ EK + +E + K E K E+E +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 825 KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKM 884
+ E + E+++L + E+ +L E+ ++ ++ + +++ + E+ ++
Sbjct: 268 QRELQEEEEQL-------RKLERQELRRERQEE-EQQQQRLRREQQLRRKQEEERREQQE 319
Query: 885 DRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944
+R+ +E+ E++ E + + E++ +Q E + + + +++E +++E+ +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 945 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1004
E + + ++ E++ + + + E+ L +++ + E ++ ++++ + R
Sbjct: 380 EQ-QLRREQQLRREQQ--LRREQQLRREQQLRREQQLRRE--------QQLRREQQLRRE 428
Query: 1005 KERDKHKDKI-QINSLLKLKSEADKPKP---KSSPASKDTRPKEKRLVNDDLMQTSFERM 1060
+E ++H+ K Q +LK E ++ + + + + + K+ + D + ER
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 1061 LSLKDLEIEQWHKKHKEKIK-------------QKEKERLRNRNCLELKIKDKEKTKHTP 1107
L L++ E + ++ +++++ Q+E+ERL+ R ++ +++ +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR------LRSEQQLRREQ 542
Query: 1108 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1142
E + + L R + + +++ ++ R Q
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Score = 75.5 bits (184), Expect = 5e-13
Identities = 70/438 (15%), Positives = 203/438 (46%), Gaps = 45/438 (10%)
Query: 726 EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 785
+E + + + ++S +++ ++ +++R P D+ +EE G +K
Sbjct: 96 DEEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQ----------LEEEPGQRRRQKR--- 141
Query: 786 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 845
++QE+ + E +E+ EK+ +++++D ++ + + + + ++ + + ++ L C
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK---- 197
Query: 846 EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905
H TE+ E + + + RE+ +++ + D+ E+E +E
Sbjct: 198 ------GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 906 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS--------KHIQE 957
L +++ K + + E + +E+ R+L+++E R+++ + QE
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 958 EKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD-------GKEKDKKDKDIDRYKERDKH 1010
E++ + + Q E+ +E+ + + + + +E++++ ++ +E+++
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 1011 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1070
+ + Q+ +L+ E + + + R +E++L + ++ +++ + L EQ
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRRE-QQLRREQQLRREQ 429
Query: 1071 WHKKHKEKIKQKEKERLRNRNCLELK--IKDKEKTKHTPTESKNKELTRSKSSEVTDAYT 1128
++H++K +Q+ +E+ R E + +K +E+T+ E + ++L R + E + +
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 1129 K--EKQPKDAVSNRSQSV 1144
K E++ ++ R Q +
Sbjct: 490 KLEEEERREQQERREQQL 507
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 101 bits (252), Expect = 7e-21
Identities = 153/621 (24%), Positives = 250/621 (40%), Gaps = 94/621 (15%)
Query: 261 GERPVDVAETEELELLLKREVPLSDDDESYT----------DSEEAQSVNPSSVDENIDS 310
G+RP+D E EEL + KR LS ++ S Q + P ++
Sbjct: 177 GKRPLDSPEAEELPAM-KRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQD 235
Query: 311 ETEKDSLICESKQILP-SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 369
T+ E + P +K+ +P+A K ++ + K + K + P
Sbjct: 236 STDLAPPSPEPPMLAPVAKSQMPTA---------------KPLETKSFTPKTKTKTSSPG 280
Query: 370 AEKTHLFAKQEKAFY------PKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST---SC 420
+ Q A PK+ +K+ P R S ++ ++ K++T
Sbjct: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------SKSPKSPKSPKVTTHIPQT 333
Query: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
V PET N +S E Q +++ N ENQ K + +
Sbjct: 334 PVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAV--------VADK 385
Query: 481 TVNTGLD------CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP 534
T+ +D C+E RE F FS ++ +F SPK G + +TP
Sbjct: 386 TIEASIDAVIARACAE--REPDPFE--FSSGSESEGDIF-----TSPKRISG--PECTTP 434
Query: 535 LKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG 594
GS+ + L DN+ + V+ K S +F
Sbjct: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS 494
Query: 595 EKSNAKIKDEDHSPTFENSDC-----TLKKMDKEGKTLKKHKLKHKEREKEKHK-KEIEG 648
+ + H E + KK+ KE KT K K K ++RE+EK K K+
Sbjct: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSK 554
Query: 649 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 708
EK+K K K+ KE R ++ WKE F K +E + ++ E ++ K KL+ +
Sbjct: 555 EKDKVKEKEKDKETGRETKYP---WKE-FLKEEEADPYKFKIK-EFEDVDPKVKLKDGLV 609
Query: 709 DDKSTKEKHVSKERNFKEERDKIKKESEK---SFREEKIK----DLKEERENIPTDKDSE 761
+ K K K+R K ++DK K+E EK RE+K+K L + + S
Sbjct: 610 RKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668
Query: 762 FTSLGMSAIEESIGLHLVEK------EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 815
T+ + A+ S+ L EK ++ ++++K KE K+K EK + KEK+ EK E+
Sbjct: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK-EK 727
Query: 816 KTFEKEKKIKHEHKSEKDKLD 836
+ EK +K K +HK EK K++
Sbjct: 728 REREKREKEKEKHKHEKIKVE 748
Score = 70.5 bits (171), Expect = 2e-11
Identities = 74/228 (32%), Positives = 102/228 (44%), Gaps = 42/228 (18%)
Query: 905 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHIQEEKKSSI 963
K M+KK KQ D EK KNK+K +E DK KEK +DKE+ E K
Sbjct: 530 KTKMKKKEKQRDRER----EKDKNKDKSKEKDKVKEKEKDKET---------GRETKYPW 576
Query: 964 VDGNKAQHEKPLSLKEKT---KDEPLKTPDGKEKDKKDKDIDRYKERD---KHKDKIQIN 1017
+ K + P K K D +K DG + +K+K D+ K+R+ K KDK +
Sbjct: 577 KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE-K 635
Query: 1018 SLLKLKSEADKPK---------------PKSSPASKDTRPKEKRLVNDDLMQTSFERMLS 1062
+K K DK K P SPA+ P + L + FE
Sbjct: 636 EKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEK 695
Query: 1063 LKDLE-----IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1105
+K+ E E+ KK KEK ++KEKER + + E + K+KEK KH
Sbjct: 696 VKEKEKKKDKKEKKKKKEKEK-EKKEKEREKEKREREKREKEKEKHKH 742
Score = 70.1 bits (170), Expect = 2e-11
Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 55/268 (20%)
Query: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 852
K +EK + S ++ K K E KT K+K+ + + + EKDK DK KEKDK+
Sbjct: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK-----DKSKEKDKV-- 559
Query: 853 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
KE EK K T K +E +E+ E + + + KE ++ K
Sbjct: 560 -------KEKEKDKETGRETKYPWKEFLKEE----------EADPYKFKIKEFEDVDPKV 602
Query: 913 KQSDNSEYSKSEKGKNKEKDRELDKKEK-SRDKESINITNSKHIQEEKKSSIVDGNKAQH 971
K D + EK K+K+KDRE KK+K R+KE + K +++ K+
Sbjct: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV---KDKGREDKMKAP--------- 650
Query: 972 EKPLSLKEKTKDEPLKTPDGKEK-------------DKKDKDIDRYKERDKHKDKIQINS 1018
PL L K PL +P + +K ++ ++ KE++K KDK +
Sbjct: 651 APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE--- 707
Query: 1019 LLKLKSEADKPKPKSSPASKDTRPKEKR 1046
K K E +K K K K+ R +EKR
Sbjct: 708 -KKKKKEKEKEK-KEKEREKEKREREKR 733
Score = 69.3 bits (168), Expect = 4e-11
Identities = 71/250 (28%), Positives = 123/250 (49%), Gaps = 40/250 (16%)
Query: 698 EKKSKL------EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 751
E+K+KL +K +K + TK K K+R+ + E+DK K +KS ++K+K+ ++++
Sbjct: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK---DKSKEKDKVKEKEKDK 566
Query: 752 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDI 810
E T +++++ EE+ KE + + +K+ + EK + + K+KD
Sbjct: 567 E---TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623
Query: 811 EKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKD-KLYSHHT------------- 855
EK ++ ++EK K+K + + +K K V KE L+S T
Sbjct: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
Query: 856 ---EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
EK +E EK K KK D +EK ++K + +KEK EKER KEK EK+
Sbjct: 684 VLPEKLFEEKEKVKEKE--KKKDKKEKKKKK---EKEKEKKEKER----EKEKREREKRE 734
Query: 913 KQSDNSEYSK 922
K+ + ++ K
Sbjct: 735 KEKEKHKHEK 744
Score = 63.5 bits (153), Expect = 2e-09
Identities = 75/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)
Query: 780 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH-------EHKSEK 832
E + ++K+EK +EK + + + KEKD K + K E ++ K+ E +++
Sbjct: 528 ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587
Query: 833 DKLDLSECVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHD 889
K + E D K+K KD L EK HK+ +K + K D REK + K + D
Sbjct: 588 YKFKIKEFEDVDPKVKLKDGLVRKEKEK-HKDKKKDREKGK-KDKDKREKEKVKDKGRED 645
Query: 890 KEK--------PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 941
K K P KE L + + KEK +E +KK+
Sbjct: 646 KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705
Query: 942 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDI 1001
++K+ K ++EKK + K + EK KEK K E +K I
Sbjct: 706 KEKK-----KKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE--PVALAPSPVI 758
Query: 1002 DRYKER-DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1043
R R +DKI I+ ++ P P++ PA RPK
Sbjct: 759 PRLTLRVGAGQDKIVISKVV--------PAPEAKPAPSQNRPK 793
Score = 39.7 bits (91), Expect = 0.030
Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 14/221 (6%)
Query: 1033 SSPASKDTRPKEKRLVNDDL--MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1090
SSP+ P+ V ++ + +S E LK + KK K++ +++EK++ +++
Sbjct: 493 SSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK 552
Query: 1091 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVM 1150
+ + K+K+KEK K T E+K K E K K+ +D VD K +
Sbjct: 553 SKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED--------VDPKVKL 604
Query: 1151 TLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDF 1210
G + ++ E K R + ED + P PP+
Sbjct: 605 KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK----MKAPAPPLVLPPKE 660
Query: 1211 MLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIK 1251
+ S + S+ P + + P L E+ + + E+ K
Sbjct: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
Score = 39.3 bits (90), Expect = 0.040
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 968 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1027
K + + +K+K K E LKT + KK+K DR +E+DK+KDK + +
Sbjct: 512 KTKLPSSVEVKKKLKKE-LKT----KMKKKEKQRDREREKDKNKDKSK-----------E 555
Query: 1028 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1087
K K K K+T +T + LK+ E + + K KE K +L
Sbjct: 556 KDKVKEKEKDKETG-----------RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
Query: 1088 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1136
++ + K K K+K K K+K+ + + +V D ++K A
Sbjct: 605 KDGLVRKEKEKHKDKKKDREKGKKDKD--KREKEKVKDKGREDKMKAPA 651
Score = 32.7 bits (73), Expect = 3.7
Identities = 26/122 (21%), Positives = 48/122 (39%), Gaps = 21/122 (17%)
Query: 37 YSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKK 96
+ + K++ + K+ KEK K K E+++ + EKE E++K +KE K
Sbjct: 690 FEEKEKVKEKEKKKDKKEKKKKKEK--------EKEKKEKEREKEKREREKREKEKEKHK 741
Query: 97 STPVSI----LFGYPLSER---------KQMALLMQMTARDNSPDSTPNHPSQTTPAQKK 143
+ + L P+ R ++ + + A + P + N P PA
Sbjct: 742 HEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAP 801
Query: 144 TP 145
P
Sbjct: 802 AP 803
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 100 bits (250), Expect = 1e-20
Identities = 53/127 (41%), Positives = 79/127 (62%), Gaps = 2/127 (1%)
Query: 161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
R TPLH AA V V+ L+ GA+V+ KD G PLH AC+ G+Y+VA++L+ GA
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 221 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLK 278
VN L TPLH++A+ G +I KLLL+HG +P + N+ G P+D+ + + ++ LL+
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLR 644
Query: 279 REVPLSD 285
+ L D
Sbjct: 645 GDAALLD 651
Score = 93.2 bits (230), Expect = 2e-18
Identities = 51/134 (38%), Positives = 76/134 (56%), Gaps = 2/134 (1%)
Query: 153 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 210
D VN R+ +G TPLH+AA +++ + L+ GA+VN +D G PLH A + G+ DV
Sbjct: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
Query: 211 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 270
A +LI A VN TPLH++A G + LLL HG +P N+ G+ P+D+
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Query: 271 EELELLLKREVPLS 284
+++ LL +P S
Sbjct: 788 DDVSALLTAAMPPS 801
Score = 92.0 bits (227), Expect = 5e-18
Identities = 49/120 (40%), Positives = 71/120 (59%)
Query: 161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
R TPLH+AA VK V+ L+ GA+V+ KD PLH AC+ G+Y+V ++L+ GA
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Query: 221 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 280
VN L TPLH++AS ++ LLL +G +P N H + +D+A T +L+ L E
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329
Score = 87.4 bits (215), Expect = 1e-16
Identities = 48/119 (40%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 153 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 210
+KVN R+ G TPLH AA G V+ L+ GANV +D G PLH AC+ G+ +V
Sbjct: 47 EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106
Query: 211 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 269
+L+ GAD N + + TPLH++A G D+ +LL+HG P N G +D+A+
Sbjct: 107 VNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Score = 63.5 bits (153), Expect = 2e-09
Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 1/93 (1%)
Query: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
V+ +++ G PLH A G + + L+ GA VNV D +TPLHEA G Y++ K+L
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 215 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
+ GAD + D +TPL D G DI LL
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLL 643
Score = 54.3 bits (129), Expect = 1e-06
Identities = 46/148 (31%), Positives = 70/148 (47%), Gaps = 6/148 (4%)
Query: 157 KRNERGETPLHMAAIRG--DVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 213
K + ET LH AA KQ+ EL+ GAN+N K TPLH A + DV ++
Sbjct: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
Query: 214 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 273
++ A VN T LH +A GH +LLL +G +P + G + + E +
Sbjct: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-NENV 477
Query: 274 ELLLKREVPL--SDDDESYTDSEEAQSV 299
+ LL+ + L S+ D ++ +A V
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDV 505
Score = 53.9 bits (128), Expect = 2e-06
Identities = 28/86 (32%), Positives = 44/86 (51%)
Query: 166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 225
L A + K + L L N + D TPLH A + ++L+ GADV+ +
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241
Query: 226 LDDDTPLHDSASSGHRDIVKLLLRHG 251
D PLH++ S GH ++ +LL++HG
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHG 267
Score = 48.1 bits (113), Expect = 9e-05
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 109 SERKQMALLMQMTARDNSPD---STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETP 165
+E K MALL + ++ D STP H + K D V+ +++ P
Sbjct: 189 NEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD-VHAKDKGDLVP 247
Query: 166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
LH A G + + L+ GA VN D +TPLHEA + +V +L++ GAD
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Score = 46.6 bits (109), Expect = 2e-04
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 4/109 (3%)
Query: 139 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 198
P +K+ R+ +N++ + TPLH+A+ + V+ ++ A VN D G T
Sbjct: 377 PKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436
Query: 199 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 247
LH A G+ ++L++ G D N L T L G+ ++ +LL
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL----QMGNENVQQLL 481
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 100 bits (248), Expect = 2e-20
Identities = 132/577 (22%), Positives = 233/577 (40%), Gaps = 79/577 (13%)
Query: 524 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 583
SCG +S K+E + S SS S D + S+ S+ + K K
Sbjct: 173 SCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKK 232
Query: 584 KHQKDFHLEFGEKSNAK----------------------IKDEDHSPTFENSDCTLKKMD 621
KH+K+ EK K ++ E+ P EN K
Sbjct: 233 KHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPP 292
Query: 622 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ----RSVEFDREFWKENF 677
K + +K++ + +ERE + + + S ++++ R +
Sbjct: 293 KADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352
Query: 678 FKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKS----TKEKHVS----KERNFKEERD 729
F+ ET + E + + S E+ IK DKS KE S KER + R+
Sbjct: 353 FRRSETPPHW-RQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRN 411
Query: 730 KIKKESEKSFREEKIKDLK---EERE-NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 785
+ + K+ +E+K+KD K +ER+ ++KD ++ + + EK
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 786 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS---EKDKLDLSECVD 842
E+ KH E+ RS+ K +D E ++ K + + K K + +S EK K S+ +
Sbjct: 472 ERDSKH--NRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNE 529
Query: 843 ----KIKEKDKLYSHHTEKCH-KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKER 897
K KEKD+ + +C +G+ S N+ +++ R++SR R HD+++
Sbjct: 530 HDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDR----- 584
Query: 898 HLAESKEKHL---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE--KSRDKESINITNS 952
+ SKE H E + + S ++ G+++ KDR +++ S +ES +
Sbjct: 585 --SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKD 642
Query: 953 KHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGKEKDKKDKDIDRY-KERD 1008
K+ +E KSS H K S EK +K + + + K D+D + K +
Sbjct: 643 KYRNQESKSS--------HRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQ 694
Query: 1009 KHKDKIQINSLL------KLKSEADKPKPKSSPASKD 1039
+D +S+L K++S +K KS D
Sbjct: 695 SSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEND 731
Score = 99.4 bits (246), Expect = 3e-20
Identities = 129/630 (20%), Positives = 260/630 (41%), Gaps = 69/630 (10%)
Query: 385 PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 444
PKS K KK++ R SS+ SS + S S S ++S+S+ T +
Sbjct: 179 PKS-KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSS---DSSDSESAT----------E 224
Query: 445 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 504
+K K ++K +N K +E K+ K+ K++ SE E + + P
Sbjct: 225 EKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSE----------SEAENLEAQPQSTVRP 274
Query: 505 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE 564
++ + KSP + EK+ ++E + C P S S Q L+
Sbjct: 275 EEIPPIPENRFLMRKSPPKA---DEKERKNRERERERECNPPNSQPASYQRRLL------ 325
Query: 565 SEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 624
V K K + + + +S + + + P + +E
Sbjct: 326 ---------VTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWR----------QEM 366
Query: 625 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 684
+ ++ ++ ER + K E+ KE ++ KE + + D E+ + +E E
Sbjct: 367 QRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKIT---DHRNVSESPNRKNEKE 423
Query: 685 DLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEK 743
+ + S + + EK+ K K++ SK R+ +E+ K K+ K R EEK
Sbjct: 424 KKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEK 483
Query: 744 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 803
+ + + K+ E S +E K+++ + E +SKEK ++R+
Sbjct: 484 RMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEK-DRRA 542
Query: 804 QIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE 863
Q + ++ + + K + + ++ + S D+ + + K Y + E+ ++
Sbjct: 543 QSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRG 602
Query: 864 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 923
+S++ + R +S+++ R+ D E+E + +K+K+ +++K S E S+S
Sbjct: 603 RSRSRER-RTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKY-RNQESKSSHRKENSES 660
Query: 924 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD 983
EK + K R+ + SR+K K +++ S + + +E S+ + +D
Sbjct: 661 EK-RMYSKSRDHNSSNNSREK--------KADRDQSPFSKIKQSSQDNELKSSMLKNKED 711
Query: 984 EPLKTPDGKEKDK-KDKDIDRYKERDKHKD 1012
E +++ KE K K ++ D E++K D
Sbjct: 712 EKIRSSVEKENQKSKGQENDHVHEKNKKFD 741
Score = 72.8 bits (177), Expect = 3e-12
Identities = 121/637 (18%), Positives = 245/637 (38%), Gaps = 95/637 (14%)
Query: 278 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 337
KR S S +DS+ + SS + +S TE+ S + K S+
Sbjct: 189 KRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSR--------- 239
Query: 338 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 397
+ K + + RK+ +K E+E +L A+ + P+ +
Sbjct: 240 -KHKKEKKK------------RKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPEN-RF 285
Query: 398 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 457
++ S +DE+ +N++ P S ++ V K KG+ R+ + +
Sbjct: 286 LMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPS 345
Query: 458 KNKENQELKQEKE----GKENTRITNLTVNTGL-----DCSEKTREEGNFRKSFSPKDDT 508
+++ ++ + +E R + V++G D SE + N R K+
Sbjct: 346 RSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK 405
Query: 509 SLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFL 568
H + +SP K E K S+ S + D+ R N+E +
Sbjct: 406 ITD--HRNVSESPNR------------KNEKEKKVKDHKSN--SKERDIRR--NSEKDDK 447
Query: 569 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 628
++ K K K +SK + EKS +K +D H+ E K+M K
Sbjct: 448 YKNKVKKRAKSKSRSKSK--------EKSKSKERDSKHNRNEE------KRMRSRSKGRD 493
Query: 629 KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFL 688
+K KE++ + K ++E+ ++K+ +K+L+ KS+E +
Sbjct: 494 HENVKEKEKQSDSKGK----DQERSRSKEKSKQLES--------------KSNEHD---- 531
Query: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 748
S + EK + + ++ TK KH R + R + + +S ++ +
Sbjct: 532 ----HSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRS 587
Query: 749 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
+E ++ E+ G S E + D ++ + S E+ E +S+ K+K
Sbjct: 588 KEYHRY---REQEYRRRGRSRSRERRTPPGRSRSKD-RRRRRRDSRSSEREESQSRNKDK 643
Query: 809 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNT 868
+ + + KE + K + S + K+ D+ S + K + + ++
Sbjct: 644 YRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFS-KIKQSSQDNELK 702
Query: 869 AAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905
+++ K + EK R +++++ K K ++ H+ E +K
Sbjct: 703 SSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739
Score = 65.1 bits (157), Expect = 7e-10
Identities = 94/451 (20%), Positives = 184/451 (40%), Gaps = 83/451 (18%)
Query: 728 RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 787
+ K+KKE +K K + + DS+ +S S+ + S E EK
Sbjct: 180 KSKVKKEEKKRH--------KSSSSSSSSSSDSDSSSDSQSSSDSSDSESATE-----EK 226
Query: 788 QEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEK 847
+K ++ K + R KEK K +K+ E + ++ + + E + I E
Sbjct: 227 SKK--RKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEE-IPPIPEN 283
Query: 848 DKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHL 907
L KS A K+ +RE+ RE+ + + +R L ++
Sbjct: 284 RFLM-----------RKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSG-- 330
Query: 908 MEKKNKQSDNSEYSKSEKGKNKEKDR----------ELDKKEKSR----------DKESI 947
+K K Y + +++++ R E+ + ++ R DK +
Sbjct: 331 --RKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSEL 388
Query: 948 NITNSKHIQEEKKSSI-VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1006
N I+E ++S + V K + +S K+E K + + K++DI R E
Sbjct: 389 N-----EIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443
Query: 1007 RD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1065
+D K+K+K++ + K +S++ + SK R +EKR+ +
Sbjct: 444 KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM----------------RS 487
Query: 1066 LEIEQWHKKHKEKIKQ---KEKERLRNRNCLELKIKDKEKTKHTPTESKNKE---LTRSK 1119
+ H+ KEK KQ K K++ R+R+ + K + + +H ++SK K+ +RS+
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Query: 1120 SSEVT---DAYTKEKQPKDAVSNRSQSVDTK 1147
++T +Y + + +RS+ V ++
Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSRRVRSR 578
Score = 61.6 bits (148), Expect = 7e-09
Identities = 78/380 (20%), Positives = 156/380 (41%), Gaps = 45/380 (11%)
Query: 806 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD-------KIKEKDKLYSHHTEKC 858
K K EK K+ + S D S+ D K K++ K + ++ K
Sbjct: 182 KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKH 241
Query: 859 HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE-KPEKERHLAESKEKHLMEKKNKQSDN 917
KE +K K + KK+ E E ++ + +PE+ + E++ LM K ++D
Sbjct: 242 KKEKKKRKKS---KKSASSESEAENLEAQPQSTVRPEEIPPIPENR--FLMRKSPPKADE 296
Query: 918 SEYSKSEKGKNKEKDRELDKKEK-----------SRDKESINITNSKHIQEEKKSSIVDG 966
E K + +E++RE + +R I + + +S D
Sbjct: 297 KE----RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352
Query: 967 NKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-DIDRYKERDKHKDKIQINSLLKLKSE 1025
+ P +E + + ++ G+ K DK +++ KE + +++ + ++
Sbjct: 353 FRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNV 412
Query: 1026 ADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1085
++ P K+ KEK++ D S ER + + + K+K K+K++ K
Sbjct: 413 SESPNRKNE--------KEKKV--KDHKSNSKERDIRRNSEKDD----KYKNKVKKRAKS 458
Query: 1086 RLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1145
+ R+++ + K K+++ +KH E K +RSK + + KEKQ ++ +S
Sbjct: 459 KSRSKSKEKSKSKERD-SKHNRNEEKRMR-SRSKGRDHENVKEKEKQSDSKGKDQERSRS 516
Query: 1146 TKNVMTLGKSSFVSDNSLNR 1165
+ L S D+S ++
Sbjct: 517 KEKSKQLESKSNEHDHSKSK 536
Score = 48.5 bits (114), Expect = 7e-05
Identities = 74/355 (20%), Positives = 130/355 (36%), Gaps = 42/355 (11%)
Query: 332 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 391
P+ +E E K D + +K D R K+ + +N+ + ++A KSK
Sbjct: 416 PNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK----------KRAKSKSRSKSK 465
Query: 392 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 451
++ S+ S ++E+ ++++ + E K+ + + + K K
Sbjct: 466 EKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKD-----QERSRSKEKS 520
Query: 452 KLKNQNKNKENQELKQEKEGKENTRITNLTVNTGL-DCSEKTREEGNFR------KSFSP 504
K N+ + +EK+ + +R + G + +TRE R +S +
Sbjct: 521 KQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580
Query: 505 KDDTS----LHLF----HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPD 556
D S H + + G+S +S + + E S +
Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRN 640
Query: 557 LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 616
+Y N ES +SS K EK + K S K D D SP +
Sbjct: 641 KDKYRNQES----KSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSP------FS 690
Query: 617 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE 671
K + LK LK+KE EK + E E +K K + D E ++ +FD E
Sbjct: 691 KIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE--KNKKFDHE 743
Score = 34.3 bits (77), Expect = 1.3
Identities = 38/163 (23%), Positives = 59/163 (36%), Gaps = 15/163 (9%)
Query: 13 ENSDSDSNMVEKPYGRK---SKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPS 69
EN +D+ KP+ S ++ SK K E+ SS + S S
Sbjct: 155 ENQKTDA--ASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQS 212
Query: 70 RNEERDSDTEKEGPEKKKTKKEAGN-------KKSTPVSILFGYPLSERKQMALLMQMTA 122
++ DS++ E KK+ KK N KK S SE + + Q T
Sbjct: 213 SSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTV 272
Query: 123 RDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETP 165
R P+ P P +K P + +++ + ER P
Sbjct: 273 R---PEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNP 312
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 99.8 bits (247), Expect = 2e-20
Identities = 145/664 (21%), Positives = 269/664 (40%), Gaps = 103/664 (15%)
Query: 519 KSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD----------NTESEFL 568
+ P+ S G +K+ KQ+ + + E+SL+ ++ D N E EF
Sbjct: 35 QEPQKSKGKKKKEKK--KQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 569 PESSSVKSCKHKEKSKHQKDFH----LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 624
+ K K K++S D + K AK K E +S + ++ D +G
Sbjct: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
Query: 625 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEF--DREFWKENFFKSDE 682
K K +K E E + K+I KE+ + S + S EF R+ K+N
Sbjct: 153 KAQKSNKKWDGSEEDEDNSKKI---KERSRINSSGESGDESDEFLQSRKGQKKN------ 203
Query: 683 TEDLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEK 737
+K+K NI+ DD S K K V++++ K+ER++ K++ EK
Sbjct: 204 ----------------QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247
Query: 738 SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI--EKQEKHIKES 795
+ K++ LKE+ E KD EE V + + +EK +
Sbjct: 248 A----KLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 796 KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
+ + K+KD +K + + EKEK+ K + S+ + E + K+KE+++
Sbjct: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKE-KKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK--EKHLMEKKNK 913
E+ K E+ + K+ ++ +EK +RK KEK KER E K K E + +
Sbjct: 363 EERIKRLEELE----AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
Query: 914 QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 973
+ +++ + KD K+ DK+ I +E +S + E+
Sbjct: 419 AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ 478
Query: 974 PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK--ERDKHKDKIQINSL-LKLKSEADKPK 1030
+ KE+T P +E+D +D +D ++ D+ +K++ N + +++K ++ +
Sbjct: 479 GVPEKEET---PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535
Query: 1031 PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1090
+ +D +E+ E E+ + E ++ E
Sbjct: 536 EEEEEEEEDEESEEE---------------------EEEEGESEGSEGDEEDE------- 567
Query: 1091 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQS---VDTK 1147
K+ D++ + T + +KE++ + D TKE++ D R + +K
Sbjct: 568 -----KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
Query: 1148 NVMT 1151
NV T
Sbjct: 623 NVNT 626
Score = 94.0 bits (232), Expect = 1e-18
Identities = 142/619 (22%), Positives = 259/619 (41%), Gaps = 108/619 (17%)
Query: 600 KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSA 659
K K ED + + D +++ G K +E +K K KK+ E +K+ + D
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAA------KEQEPQKSKGKKKKEKKKQDFDEDDIL 59
Query: 660 KELQ------RSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK----- 708
KEL+ + ++ DRE TE N E E + +KK K +K K
Sbjct: 60 KELEELSLEAQGIKADRE-----TVAVKPTE----NNEEEFTSKDKKKKGQKGKKQSFDD 110
Query: 709 ------DDKSTKEKHVSKER-----------NFKEERDKIKKESEKSFR--------EEK 743
+DK +K K +K + +F + K K +++KS + E+
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 744 IKDLKEERENIPT-----DKDSEFTSL--------------GMSAIEESIGLHLVEKEID 784
K +K ER I + D+ EF + + E K +
Sbjct: 171 SKKIK-ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA 229
Query: 785 IEKQEKHIKESKEKPEKRSQIKE-KDIEKMER----KTFEKEKKIKHEHKSEKDKLDLSE 839
+K EK +E K++ E+++++++ K+ E++E ++ +KE + K E ++ K K+ +
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289
Query: 840 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK-----------MDRKH 888
V E +K + + EG+K K KK + EK +EK M
Sbjct: 290 GVIPASE-EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
Query: 889 DKEKPEKERHLAESKEK----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944
K K E+ER E +E+ +E K K+ + E K E+ K KEK+R KE+ + K
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER----KERLK-K 403
Query: 945 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1004
E +T S+ + + + +AQ + S K P+ +DKK K I +
Sbjct: 404 EGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPI------YEDKKRKKIPQQ 457
Query: 1005 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1064
E + + +++ + +++ + K ++ P P+E+ +D +E M S +
Sbjct: 458 LESKEVSESMELCAAVEVMEQGVPEKEETPP---PVEPEEEE-DTEDAGLDDWEAMASDE 513
Query: 1065 DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE-SKNKELTRSKSSEV 1123
+ E + +K H E + E+E E + ++E+ + +E S+ E S E
Sbjct: 514 ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 1124 TDAYTKEKQPKDAVSNRSQ 1142
T +K+P +S+ S+
Sbjct: 574 DSGKTLDKKPSKEMSSDSE 592
Score = 87.4 bits (215), Expect = 1e-16
Identities = 155/658 (23%), Positives = 272/658 (41%), Gaps = 111/658 (16%)
Query: 337 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 396
E + +D D+++I K +++ + + + + E A K E+ F K K K QK
Sbjct: 47 EKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT--ENNEEEFTSKDKKKKGQKGK 104
Query: 397 RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 456
+ + +S + E +K T+ + S SD + K KGK ++ K
Sbjct: 105 KQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPK---KAKGKAQKSNKKW 161
Query: 457 NKNKENQELKQEKEGKENTRITN-----------LTVNTGLDCSEKTREEGNFRKSFSPK 505
+ ++E+++ K+ KE +RI + L G ++K + N +S +
Sbjct: 162 DGSEEDED--NSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI-ESGNED 218
Query: 506 DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTES 565
DD S + ++ K+ K K+ K++ K L
Sbjct: 219 DDASFKIKTVAQKKAEK-------KERERKKRDEEKAKLRK------------------- 252
Query: 566 EFLPESSSVKSCKHKEKSKHQKDFHLEFGEKS-NAKIK-DEDHSPTFENS--DCTLKKMD 621
L E +++ K K++SK QK+ +F E++ +K+ D P E T + D
Sbjct: 253 --LKEKEELETGK-KDQSK-QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD 308
Query: 622 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 681
EG KK K K K ++EK K EK+K +K + K +Q ++ +E E +
Sbjct: 309 NEGDKKKKDKKKKKGEKEEKEK-----EKKKGPSKATVKAMQEALAKLKE---EEERQKR 360
Query: 682 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 741
E E+ +E +++ +LE+ ++ K KEK KER KE + K + E R
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE-RKERLKKEGKLLTKSQREARARA 419
Query: 742 EK-IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 800
E +K L+ + +P+ KDS + I K+I + + K + ES E
Sbjct: 420 EATLKLLQAQGVEVPS-KDS-------LPKKRPIYEDKKRKKIPQQLESKEVSESMELCA 471
Query: 801 KRSQIKEKDIEKMERKTFEKEK-----KIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
+E ME+ EKE+ + + E +E LD E + +E +K+ +
Sbjct: 472 A--------VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGN-- 521
Query: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 915
K H E K + E+ E+ + + D+E E+E ES+ E+ K S
Sbjct: 522 -KVHIE----------VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570
Query: 916 DNSEYSKS---EKGKNKEKDRELD------KKEKSRDK-----ESINITNSKHIQEEK 959
D + K+ + K D E D K+E++ DK E + +SK++ EK
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
Score = 65.1 bits (157), Expect = 7e-10
Identities = 132/644 (20%), Positives = 249/644 (38%), Gaps = 69/644 (10%)
Query: 282 PLSDDDESYTDSEE---AQSVNPSSVDENIDSETE-KDSLICESKQILPSKTPLPSALDE 337
P +++E +T ++ Q S D+N E E KDS +SK+ K + S D
Sbjct: 83 PTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS---KSKKTAKPKVEMYSGSD- 138
Query: 338 YEFKDDDD------------EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 385
DDDD ++ NK D +K E + + E +
Sbjct: 139 ----DDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 386 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVS-GEHK 444
+S K +K+ + ES +E+ + KI T E + + + E + K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254
Query: 445 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG-LDCSEKTREEGNFRKSFS 503
+K +++ K+Q+K KE+Q ++ +E T + +TV+TG + SE+ E + +
Sbjct: 255 EKEELETGKKDQSKQKESQ-----RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309
Query: 504 PKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMS-LQPDLVRYDN 562
D K K G E++ K+ +K + ++ L+ + R
Sbjct: 310 EGDKKK---------KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Query: 563 TESEFLPESSSVKSCKHKEKS--------KHQKDFHLEFGEKSNAKIKDEDHSPTFENSD 614
E E + +++ + +E+ K QK+ + K K+ + ++
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
Query: 615 CTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR--EF 672
TLK + +G + K+R + KK ++K + +KE+ S+E E
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKK-----RKKIPQQLESKEVSESMELCAAVEV 475
Query: 673 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK 732
++ + +ET E E E D+++ K V + E ++ +
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEK---VEGNKVHIEVKENPE 532
Query: 733 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 792
+E E+ EE+ ++ +EE E + SE +E ++K+ E
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Query: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD--KIKEKDKL 850
+S + K + +K ++E++ E K + E K + + VD K K DKL
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTE-KLRAPIICVLGHVDTGKTKILDKL 651
Query: 851 YSHHTEKCHKEGEKSKNTAAIKKTD---DREKSREKMDRKHDKE 891
H + +GE T I T+ + + KM + D+E
Sbjct: 652 RHTHVQ----DGEAGGITQQIGATNVPLEAINEQTKMIKNFDRE 691
Score = 56.6 bits (135), Expect = 2e-07
Identities = 93/537 (17%), Positives = 204/537 (37%), Gaps = 67/537 (12%)
Query: 235 SASSGHRDIVKLLLRHGGNPFQANKH---GERPVDVAETEELELLLKREVPLSDDDESYT 291
S S D KL + G ++NK E D ++ + + D+ + +
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 292 DSEEAQSVNPSSVD-ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINK 350
S + Q N + NI+S E D + K + K E + +D++ ++ K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER--ERKKRDEEKAKLRK 252
Query: 351 MIDDRHI--------LRKEQRKENEPEAEKTHLF-------AKQEKAFYPKSFKSKKQKP 395
+ + + +KE +++ E E K+ + A +EKA P + + +
Sbjct: 253 LKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGD 312
Query: 396 SRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKN 455
+ + ++E + +K + + KE + +++ ++KR +
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL 372
Query: 456 QNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF----RKSFSPKDDTSLH 511
+ K KE + L+QEK ++ + + E+ ++EG ++ + + +L
Sbjct: 373 EAKRKEEERLEQEKRERKKQK--------EKERKERLKKEGKLLTKSQREARARAEATLK 424
Query: 512 LFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 571
L + P L +K+ ++ K S E+S +L + +PE
Sbjct: 425 LLQAQGVEVPSKD-SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
Query: 572 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHK 631
E+ + +D L+ D D+E + ++ +K
Sbjct: 484 EETPPPVEPEEEEDTEDAGLD---------------------DWEAMASDEETEKVEGNK 522
Query: 632 LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME 691
+ + +E + ++E E E+E E + S E + E + + DE ++ + +
Sbjct: 523 VHIEVKENPEEEEEEEEEEE---------EDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 692 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK---ESEKSFREEKIK 745
TL+KK E + + + + +ER + + + +I+K E K+ EK++
Sbjct: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
Score = 52.0 bits (123), Expect = 6e-06
Identities = 115/629 (18%), Positives = 226/629 (35%), Gaps = 64/629 (10%)
Query: 28 RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL-----PFTISPSRNEERDSDTEKEG 82
+KSK K K + D+ KE++E S + + + P+ N E + ++ +
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKK 97
Query: 83 PEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTT-PAQ 141
+ +K KK++ + + L +K ++M + + D P + AQ
Sbjct: 98 KKGQKGKKQSFDDNDS--EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ 155
Query: 142 KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHE 201
K ++D+ N + + + ++ + GD G N K+ G P E
Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG--PNIE 213
Query: 202 ACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI-VKLLLRHGGNPFQANKH 260
+ N D A I A + + + D + R + K L G K
Sbjct: 214 SGNED--DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271
Query: 261 GERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICE 320
+R + + + +P S++ + E + + + EK+ E
Sbjct: 272 SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKE 331
Query: 321 SKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQE 380
K+ PSK + A+ E K ++EE K ++ I R E+ + E E+ ++
Sbjct: 332 KKK-GPSKATV-KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
Query: 381 KAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVS 440
K K K + +K ++L S + A K+ + V E + D KK +
Sbjct: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV--EVPSKDSLPKKRPIY- 446
Query: 441 GEHKQKGKVKRKLKNQNKNKENQEL-------------KQEKEGKENTRITNLTVNTGLD 487
E K++ K+ ++L+++ + E+ EL K+E T + GLD
Sbjct: 447 -EDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
Query: 488 CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPG 547
E + K K HI ++P+ E++ + E
Sbjct: 505 DWEAMASDEETEKVEGNK-------VHIEVKENPEEEEEEEEEEEEDEESEE-------- 549
Query: 548 SSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHS 607
E E ES + + EK +KD +K + ++ +
Sbjct: 550 ----------------EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY 593
Query: 608 PTFENSDCTLKKMDKEGKTLKKHKLKHKE 636
+ ++ + DK + ++K +L+H +
Sbjct: 594 DSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
Score = 31.6 bits (70), Expect = 8.3
Identities = 31/150 (20%), Positives = 63/150 (42%), Gaps = 22/150 (14%)
Query: 9 PIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
P++ E + + G + +AS +T K+E + V E+KE + +
Sbjct: 489 PVEPEEEEDTEDA-----GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEE------E 537
Query: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPD 128
EE D ++E+E E+ +++ G+++ VS E+ L + +++ S D
Sbjct: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS-------DEKDSGKTLDKKPSKEMSSD 590
Query: 129 STPNHPSQTTPAQKKTPSSSSRQKDKVNKR 158
S + T K + + K ++ KR
Sbjct: 591 SEYDSDDDRT----KEERAYDKAKRRIEKR 616
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 99.4 bits (246), Expect = 3e-20
Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)
Query: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 312
NP +N E V E ++L + ++++ + D S D+ + + S E +D +
Sbjct: 633 NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 691
Query: 313 EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 372
+ D ++ K++ S + D D EI+ + L+ + K+++ + ++
Sbjct: 692 DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 743
Query: 373 THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 429
+ + F K KS K + + +ESS+ ++ K+I + + T+
Sbjct: 744 KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 801
Query: 430 DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 480
+ K++ S + H +KG + KN Q + ++ E KQE+E E T +
Sbjct: 802 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 861
Query: 481 TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 525
T+ D K ++ +G + S + TSL + H+ T K
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 921
Query: 526 GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 568
GLS+ LK++ + K G+ E D + Y+++ +E L
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 569 PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 609
PE + KS K ++K+ +KD ++ EKS K D S
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 610 FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 652
++ + + K K L K K ++ +K K IE E+
Sbjct: 1042 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1101
Query: 653 YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 706
+K + KE+Q SD E N + + T KK K +
Sbjct: 1102 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1150
Query: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 765
++ K+ ++ + E D E S E+KIK + E N+ + F S
Sbjct: 1151 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1207
Query: 766 GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 801
G A+ +S+ + + + + D + + + K E K++ K
Sbjct: 1208 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1267
Query: 802 RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
+++ D E + E + KK ++ H+ + KL +S+ ++K K H
Sbjct: 1268 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327
Query: 856 EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
K K + + +++ E+ E D + + + K+ L E++ + +KK
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1387
Query: 913 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 972
++ E S SE N E++ E ++E+ ++E +EE++ D +K+ +
Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1437
Query: 973 KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1032
+++ KD+ L+T ++++ R ER++ ++K L+ E + P
Sbjct: 1438 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1491
Query: 1033 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1069
P + E + L+Q ++ LK +++
Sbjct: 1492 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1528
Score = 55.8 bits (133), Expect = 4e-07
Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)
Query: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 756
++K KL + + S+ K + + + E K K+F+ + D+K+ +
Sbjct: 315 IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 373
Query: 757 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 816
D +SEF ++ E++ H K ID + + K K EK +++KDI K E K
Sbjct: 374 DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 425
Query: 817 TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 873
K+ +H H+ +E+ + + S + K+ D+ E + + + ++
Sbjct: 426 LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 484
Query: 874 T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 919
+ ++ E + E +D + D ++ + S + ++ K N+ S+
Sbjct: 485 SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 544
Query: 920 ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 958
Y K + + + D +E +DK+ ++++H+ E
Sbjct: 545 TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604
Query: 959 KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1018
+ S +++ E L + K PL+ P + D + E K K K+ +
Sbjct: 605 EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 657
Query: 1019 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1069
K K S D PKP P SK + ++ +D+++ + S S D +I
Sbjct: 658 RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 717
Query: 1070 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1121
+ H HK K +K + + ++ D +K K + SK K T+S+SS
Sbjct: 718 EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 777
Query: 1122 EVTDAYTKE 1130
KE
Sbjct: 778 NYDSELEKE 786
Score = 39.3 bits (90), Expect = 0.040
Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)
Query: 721 ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 778
E+ ++ + KIK +SEKS + E + ++ + ++ + ++ S +
Sbjct: 250 EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 309
Query: 779 VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 833
V KE+ I+K +K I+ + + ++ + E + K +++K KS +K
Sbjct: 310 VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 367
Query: 834 KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 884
L L E ++ + + D + K HK + K + A++K D KS K+
Sbjct: 368 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 426
Query: 885 DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 942
RK D E + E + ++K+SD E + E N +D ++D S
Sbjct: 427 SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 485
Query: 943 DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 981
E I N+ + +Q +E +SS V N + + +K KT
Sbjct: 486 VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 545
Query: 982 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1014
+ P+K D +E +DKD + + ++H +
Sbjct: 546 KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604
Query: 1015 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1073
+++ LL+ P+ K++P RP E V + + E + + L + K
Sbjct: 605 EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 661
Query: 1074 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1120
K + K K+ E + +N + E+ KE ++ + + S + ++ +
Sbjct: 662 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 721
Query: 1121 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1173
+ T K + KD R + DTK + KSS +S S N
Sbjct: 722 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 780
Query: 1174 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1232
L SM + ++ T R P D D + S+ ++ S
Sbjct: 781 SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 834
Query: 1233 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1280
ERE S A+ + +RL S+S + V + + +
Sbjct: 835 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894
Query: 1281 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1340
++EVR+ + E +K +T + + Q L S++ E+ L
Sbjct: 895 SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 933
Query: 1341 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1398
S TS SK + ++ +PS + + + +E
Sbjct: 934 --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 973
Query: 1399 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1450
D E L R+ IC + P +++ K K+ D S ++ EL
Sbjct: 974 SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1030
Query: 1451 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1503
G+SC ++D S + ++ C +S + S + Y + +E G
Sbjct: 1031 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1089
Query: 1504 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1563
++ I + S ++T+ + +DA + ++ + + +KA V+
Sbjct: 1090 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1143
Query: 1564 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1620
EK N ST+ + +T SSS E ++ + + S E++ K E+LVL +
Sbjct: 1144 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1199
Query: 1621 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1680
H C S E + +++ D + PE+ I + + I ++L + S+
Sbjct: 1200 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1254
Query: 1681 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1740
E + + + EEN D++ +NQ+ +++++ + +SK+ LL K +
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1309
Query: 1741 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1767
S G + T+ + ++ +RKVS
Sbjct: 1310 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1337
Score = 37.0 bits (84), Expect = 0.20
Identities = 103/495 (20%), Positives = 180/495 (36%), Gaps = 99/495 (20%)
Query: 14 NSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR------------- 60
+S D YGR+ K + K+ + +R D S EK SMK
Sbjct: 1037 DSSEDKKSKNGAYGREKK-RCKLLGKSSR-KRQDCSSSDTEKYSMKEDGCNSSDKRLKRI 1094
Query: 61 --KLPFTISPSRNEER------DSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERK 112
+ +S RN + SD E+ + KK K+ +KK + + E+K
Sbjct: 1095 ELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-------VKEKK 1147
Query: 113 QMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR 172
+ +L + + + D T + S + + S + K+ E H +
Sbjct: 1148 RNSL--RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1205
Query: 173 --GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 230
GD E +S V V D + N +AK ++ N D+D
Sbjct: 1206 SSGD-----EALSKSVPVTVDD-------DDDDNDPENRIAKKMLLEEIKANLSS-DEDG 1252
Query: 231 PLHDSASSGHRDIVKLLLRHGGNPFQANK-HGERPVDVAETEE---LELLLKREVPLSD- 285
D G + K + G+ N+ + E D E+++ LL+ ++ +SD
Sbjct: 1253 SSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1312
Query: 286 --DDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDD 343
+E T +E + V + + SE +DS E S + E E +
Sbjct: 1313 ESGEEKKTKPKEHKEVKGRN-RRKVSSEDSEDSDFQE------------SGVSE-EVSES 1358
Query: 344 DDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSST 403
+DE+ R R + E E+ KQ+K K ++ K S
Sbjct: 1359 EDEQ-----------RPRTRSAKKAELEENQRSYKQKK-------KRRRIKVQEDSSSEN 1400
Query: 404 ESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK----LKNQNKN 459
+S+ EE + K+ E + + ++E + + K GK ++K LK+
Sbjct: 1401 KSNSEEEEEEKE--------EEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLR 1452
Query: 460 KENQE-LKQEKEGKE 473
E Q LK+E+E ++
Sbjct: 1453 TETQNALKEEEERRK 1467
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 99.4 bits (246), Expect = 3e-20
Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)
Query: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 312
NP +N E V E ++L + ++++ + D S D+ + + S E +D +
Sbjct: 671 NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 729
Query: 313 EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 372
+ D ++ K++ S + D D EI+ + L+ + K+++ + ++
Sbjct: 730 DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 781
Query: 373 THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 429
+ + F K KS K + + +ESS+ ++ K+I + + T+
Sbjct: 782 KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 839
Query: 430 DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 480
+ K++ S + H +KG + KN Q + ++ E KQE+E E T +
Sbjct: 840 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 899
Query: 481 TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 525
T+ D K ++ +G + S + TSL + H+ T K
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 959
Query: 526 GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 568
GLS+ LK++ + K G+ E D + Y+++ +E L
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 569 PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 609
PE + KS K ++K+ +KD ++ EKS K D S
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 610 FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 652
++ + + K K L K K ++ +K K IE E+
Sbjct: 1080 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1139
Query: 653 YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 706
+K + KE+Q SD E N + + T KK K +
Sbjct: 1140 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1188
Query: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 765
++ K+ ++ + E D E S E+KIK + E N+ + F S
Sbjct: 1189 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1245
Query: 766 GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 801
G A+ +S+ + + + + D + + + K E K++ K
Sbjct: 1246 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1305
Query: 802 RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
+++ D E + E + KK ++ H+ + KL +S+ ++K K H
Sbjct: 1306 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365
Query: 856 EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
K K + + +++ E+ E D + + + K+ L E++ + +KK
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1425
Query: 913 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 972
++ E S SE N E++ E ++E+ ++E +EE++ D +K+ +
Sbjct: 1426 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1475
Query: 973 KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1032
+++ KD+ L+T ++++ R ER++ ++K L+ E + P
Sbjct: 1476 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1529
Query: 1033 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1069
P + E + L+Q ++ LK +++
Sbjct: 1530 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1566
Score = 55.8 bits (133), Expect = 4e-07
Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)
Query: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 756
++K KL + + S+ K + + + E K K+F+ + D+K+ +
Sbjct: 353 IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 411
Query: 757 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 816
D +SEF ++ E++ H K ID + + K K EK +++KDI K E K
Sbjct: 412 DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 463
Query: 817 TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 873
K+ +H H+ +E+ + + S + K+ D+ E + + + ++
Sbjct: 464 LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 522
Query: 874 T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 919
+ ++ E + E +D + D ++ + S + ++ K N+ S+
Sbjct: 523 SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 582
Query: 920 ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 958
Y K + + + D +E +DK+ ++++H+ E
Sbjct: 583 TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642
Query: 959 KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1018
+ S +++ E L + K PL+ P + D + E K K K+ +
Sbjct: 643 EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 695
Query: 1019 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1069
K K S D PKP P SK + ++ +D+++ + S S D +I
Sbjct: 696 RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 755
Query: 1070 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1121
+ H HK K +K + + ++ D +K K + SK K T+S+SS
Sbjct: 756 EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 815
Query: 1122 EVTDAYTKE 1130
KE
Sbjct: 816 NYDSELEKE 824
Score = 39.3 bits (90), Expect = 0.040
Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)
Query: 721 ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 778
E+ ++ + KIK +SEKS + E + ++ + ++ + ++ S +
Sbjct: 288 EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 347
Query: 779 VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 833
V KE+ I+K +K I+ + + ++ + E + K +++K KS +K
Sbjct: 348 VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 405
Query: 834 KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 884
L L E ++ + + D + K HK + K + A++K D KS K+
Sbjct: 406 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 464
Query: 885 DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 942
RK D E + E + ++K+SD E + E N +D ++D S
Sbjct: 465 SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 523
Query: 943 DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 981
E I N+ + +Q +E +SS V N + + +K KT
Sbjct: 524 VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 583
Query: 982 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1014
+ P+K D +E +DKD + + ++H +
Sbjct: 584 KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642
Query: 1015 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1073
+++ LL+ P+ K++P RP E V + + E + + L + K
Sbjct: 643 EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 699
Query: 1074 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1120
K + K K+ E + +N + E+ KE ++ + + S + ++ +
Sbjct: 700 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 759
Query: 1121 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1173
+ T K + KD R + DTK + KSS +S S N
Sbjct: 760 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 818
Query: 1174 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1232
L SM + ++ T R P D D + S+ ++ S
Sbjct: 819 SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 872
Query: 1233 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1280
ERE S A+ + +RL S+S + V + + +
Sbjct: 873 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932
Query: 1281 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1340
++EVR+ + E +K +T + + Q L S++ E+ L
Sbjct: 933 SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 971
Query: 1341 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1398
S TS SK + ++ +PS + + + +E
Sbjct: 972 --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 1011
Query: 1399 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1450
D E L R+ IC + P +++ K K+ D S ++ EL
Sbjct: 1012 SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1068
Query: 1451 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1503
G+SC ++D S + ++ C +S + S + Y + +E G
Sbjct: 1069 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1127
Query: 1504 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1563
++ I + S ++T+ + +DA + ++ + + +KA V+
Sbjct: 1128 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1181
Query: 1564 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1620
EK N ST+ + +T SSS E ++ + + S E++ K E+LVL +
Sbjct: 1182 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1237
Query: 1621 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1680
H C S E + +++ D + PE+ I + + I ++L + S+
Sbjct: 1238 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1292
Query: 1681 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1740
E + + + EEN D++ +NQ+ +++++ + +SK+ LL K +
Sbjct: 1293 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1347
Query: 1741 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1767
S G + T+ + ++ +RKVS
Sbjct: 1348 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1375
Score = 37.0 bits (84), Expect = 0.20
Identities = 103/495 (20%), Positives = 180/495 (36%), Gaps = 99/495 (20%)
Query: 14 NSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR------------- 60
+S D YGR+ K + K+ + +R D S EK SMK
Sbjct: 1075 DSSEDKKSKNGAYGREKK-RCKLLGKSSR-KRQDCSSSDTEKYSMKEDGCNSSDKRLKRI 1132
Query: 61 --KLPFTISPSRNEER------DSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERK 112
+ +S RN + SD E+ + KK K+ +KK + + E+K
Sbjct: 1133 ELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-------VKEKK 1185
Query: 113 QMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIR 172
+ +L + + + D T + S + + S + K+ E H +
Sbjct: 1186 RNSL--RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1243
Query: 173 --GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 230
GD E +S V V D + N +AK ++ N D+D
Sbjct: 1244 SSGD-----EALSKSVPVTVDD-------DDDDNDPENRIAKKMLLEEIKANLSS-DEDG 1290
Query: 231 PLHDSASSGHRDIVKLLLRHGGNPFQANK-HGERPVDVAETEE---LELLLKREVPLSD- 285
D G + K + G+ N+ + E D E+++ LL+ ++ +SD
Sbjct: 1291 SSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1350
Query: 286 --DDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDD 343
+E T +E + V + + SE +DS E S + E E +
Sbjct: 1351 ESGEEKKTKPKEHKEVKGRN-RRKVSSEDSEDSDFQE------------SGVSE-EVSES 1396
Query: 344 DDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSST 403
+DE+ R R + E E+ KQ+K K ++ K S
Sbjct: 1397 EDEQ-----------RPRTRSAKKAELEENQRSYKQKK-------KRRRIKVQEDSSSEN 1438
Query: 404 ESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK----LKNQNKN 459
+S+ EE + K+ E + + ++E + + K GK ++K LK+
Sbjct: 1439 KSNSEEEEEEKE--------EEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLR 1490
Query: 460 KENQE-LKQEKEGKE 473
E Q LK+E+E ++
Sbjct: 1491 TETQNALKEEEERRK 1505
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 98.6 bits (244), Expect = 6e-20
Identities = 176/857 (20%), Positives = 343/857 (40%), Gaps = 173/857 (20%)
Query: 401 SSTESSD---EEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEH-----KQKGKVKRK 452
S TE++ EEA + S+S SVI + + D Q K +S +H K+ K++ K
Sbjct: 1122 SGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKD---ISKDHIALTLKRLQKIRDK 1178
Query: 453 LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLD--CSEKTREEGNFRKSFSPKDDTS- 509
+++ + + K +K+GKE I T ++ ++K + +G S + T+
Sbjct: 1179 -RDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAG 1237
Query: 510 -----------LHLFHISTGKSPKHS----------------------------CGLSEK 530
L IS G K S C L +K
Sbjct: 1238 DGSSWRDDLCRLMALRIS-GSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKK 1296
Query: 531 QSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 590
+S L ++ + P + +Q +R D + + + + +HKE ++
Sbjct: 1297 ESKVLLEDLDWDVVPPEKKPIFIQEGAIRED------MIQGVTQEVIRHKEVMPREE--- 1347
Query: 591 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDK-----EGKTLKKHKLKHKEREKEKHKKE 645
E++ K +D E + LKK K G ++ KE +K K
Sbjct: 1348 ----EQAQKKARD---MLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSP 1400
Query: 646 IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL------FLNMEHESLTLEK 699
+G K K + K RE KE S+E E++ + E + + +E+
Sbjct: 1401 KQGRKAVQKERKVGK-------IKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
Query: 700 KSKLEKNIKDDKSTKEKHVSKERNFK-----------EERDKIKKESEKSFREEKI---- 744
+ K K+ H +++K +E +K+ + EK EE++
Sbjct: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513
Query: 745 KDLKEER-----ENIPTDKDSE--FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKES-- 795
K LK E EN+ + K E + +EE + EKE + ++++HI+E
Sbjct: 1514 KKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHK 1573
Query: 796 -------KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEH--------KSEKDKLDLSEC 840
+ + EK+ +E+ + + E K ++E+++ E K +D ++++
Sbjct: 1574 WARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQA 1633
Query: 841 VDKIKEKDKLYSHHTEKCHKEGEK--SKNTAAIKKTDDREKSREKMDRKHDK-------- 890
K +K++ + EK +E EK K KK + + EK+ +K K
Sbjct: 1634 EGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNIL 1693
Query: 891 -----EKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 945
E P++E++L +++ E + + D E S E+ N+E+ + +++K+K ++E
Sbjct: 1694 AQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE 1753
Query: 946 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTK--DEPLKTPDGKEK-DKKDKDID 1002
+ + EE+ K E+ L ++EK K K P+ +E+ +K + +
Sbjct: 1754 EALAWQREKLSEEE-------TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI 1806
Query: 1003 RYKERDKHKDKIQINSLLKL----------KSEADKPKPKSSPASKDTRPKEKRLVNDDL 1052
K + K + INS+ +L K+ A + K + K + KE L N +
Sbjct: 1807 EKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKER 1866
Query: 1053 MQTSFERMLSLKD---------LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1103
+ S ++++ +K+ ++E+ + KE + K+KE+L ++++D
Sbjct: 1867 LTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSLAK 1925
Query: 1104 KHTPTESKNKELTRSKS 1120
K + +L K+
Sbjct: 1926 KQEKLAQEKMKLALEKA 1942
Score = 84.7 bits (208), Expect = 8e-16
Identities = 149/756 (19%), Positives = 305/756 (40%), Gaps = 104/756 (13%)
Query: 295 EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD-DEEINKMID 353
E +++ V+E E D + K++ L ++E +K+++ ++E K+++
Sbjct: 1688 EVKNILAQKVEELPQREQNLD---WQEKELAQELEELEWDMEELSWKEEELNQEEGKLVE 1744
Query: 354 DRHILRKEQRK---ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEA 410
++ L +E+ + E +E+ A++E+ + K + K E
Sbjct: 1745 EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQ 1804
Query: 411 LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKV----KRKLKNQNKN--KENQE 464
L KK+ + Q ++ ++ S E K K+ K+ L + KN +E ++
Sbjct: 1805 LIEKKMKLA------------QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
Query: 465 LKQEKEGK--ENTRITN-----LTVNTGLDCSEK---------TREEGNFRKSFSPKDDT 508
L Q KE R+T+ + V L K T+E+ K +T
Sbjct: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912
Query: 509 SLHLFHISTGKSPKHSCGLSEKQSTPLKQ------EHTKTCLSPGSSEMSLQPDLVRYDN 562
L + + K EK L++ + + L E +L ++ R
Sbjct: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAE 1972
Query: 563 TESEFLPESSSVKSCKHKEKSKHQKDFHLE---FGEKSNAKIK---DEDHSPTFENSDCT 616
+ + ++ + E S+ +K +E F K + + K ED E S+
Sbjct: 1973 EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIA 2032
Query: 617 LKKMD--KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK 674
K++ + + + + K + ++ KK KE K K LQ+ +R+ +
Sbjct: 2033 KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ 2092
Query: 675 ENFFKSDETEDLF-----LNMEHESLTLEKKSKLEKN---IKDDKSTKEKH--------- 717
E + LF L++E L +++ EK KD+K K
Sbjct: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRR 2152
Query: 718 -VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT--------------DKDSEF 762
++KE EE K+ ++ + +++ + EE E IP DK E
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEK 2212
Query: 763 TSLGMSAIE---------ESIGLHLVEKEIDI---EKQEKHIKESKEKPEKRSQIKE-KD 809
S + +E ES+ L +EK+ + E++E+ +E +E+ E R + +E K+
Sbjct: 2213 FSSQVDEVESEEHFSEEMESL-LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKE 2271
Query: 810 IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 869
E+ E K EKE++ K + K EK K ++ E + +EK+++ S + + E+ + +
Sbjct: 2272 EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESC 2331
Query: 870 AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNK 929
++++ DREK K +++ + E+ R +E+ L + + K+
Sbjct: 2332 SLEEEVDREKEILKKEKQFKLQ--EQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSP 2389
Query: 930 EKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVD 965
K + + + ++K + + + E+KK+++V+
Sbjct: 2390 LK-KLMSTALEMKEKTPVPVPEKQISWEDKKATVVE 2424
Score = 83.6 bits (205), Expect = 2e-15
Identities = 179/891 (20%), Positives = 354/891 (39%), Gaps = 138/891 (15%)
Query: 359 RKEQRKENEPEAEKTH-----LFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQN 413
++E K E EK H L ++E K K ++ K S++S +++
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541
Query: 414 KKISTSCSVIPETSNSDMQ-TKKEYVVSGEHKQKGKVKRKLKNQNKN-KENQELKQEKE- 470
++++ V E + Q T+++ + EHK +++ + + K +E ++L QE+E
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601
Query: 471 --------GKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK 522
+E ++ V D E + EG F + K++T
Sbjct: 1602 LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ----KEETLA------------ 1645
Query: 523 HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH--- 579
++ L QE K L + E + + + K+
Sbjct: 1646 -------QRGEKLSQEAEKLA----QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA 1694
Query: 580 -KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKERE 638
K + Q++ +L++ EK A+ +E E S + +EGK +++ K +E E
Sbjct: 1695 QKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEE 1754
Query: 639 KEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLE 698
++E E+E ++ +Q ++E ++ K E E+ L + E L +E
Sbjct: 1755 ALAWQREKLSEEETKLAQEEELLIQ-----EKEKLAQHKEKMPEEEER-LGRKREQL-IE 1807
Query: 699 KKSKLEK------NIKDDKSTKEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEER 751
KK KL + N ++ + + + +++N +E+ + +E EK + R+E + KE
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
Query: 752 ENIPTDKDSEFTSLGM-----SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 806
+ LGM + +EE + EKE I+K+EK + EK+
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKL---TQEKETVIKKKEK-----LAETEKKLVQV 1919
Query: 807 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
E + K + K +++ K+ E + K L +D KE+ L ++ +
Sbjct: 1920 EDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979
Query: 867 NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYS 921
+ K + E SR++ + ++E E++ L E H ME+ E++
Sbjct: 1980 GKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT 2039
Query: 922 KSEK----GKNK--EKDRELDKKEKSRDKESINITN-----SKHIQEEKKSSIVDGNKAQ 970
+ ++ G+ K + R+L KK +S KE + K ++E+K + + +
Sbjct: 2040 RGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099
Query: 971 HEKPLSLKEKTKDEPLKTPDGKEKD---------KKDKDIDRYKERDKHKDKIQINSLLK 1021
++ L +KE+ D KE D K +K + R + + +K + IN K
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159
Query: 1022 LKSEADKPKPKSSP-----------------------------ASKDTRPKEKRLVNDDL 1052
+ E K K S A + +PKEK D
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219
Query: 1053 MQTS---FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1109
+++ E M SL D E+E+ E+ +++E+E R E +++++E+ + E
Sbjct: 2220 VESEEHFSEEMESLLD-ELEKQESLSSEEEEEREEEEERE----EEEVREEEEERKEEEE 2274
Query: 1110 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSD 1160
+ K++ K E KEK+ ++ + + +M+ ++ +SD
Sbjct: 2275 GEEKQV--EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD 2323
Score = 83.6 bits (205), Expect = 2e-15
Identities = 179/924 (19%), Positives = 377/924 (40%), Gaps = 114/924 (12%)
Query: 271 EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 330
+E E L + LS ++E + ++ + V EN+ S K+ + +++ T
Sbjct: 1491 QEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEV----TL 1546
Query: 331 LPSALDEYEFKDDDDEEINKMIDDRH----ILRKEQRKENEPEAEKTHLFAKQEK-AFYP 385
E E K+ E + I + H I RK R E + E+ L ++EK A
Sbjct: 1547 EEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE 1606
Query: 386 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 445
+ +++K ++ T+ E A K + + + +S E ++
Sbjct: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEK---------LSQEAEK 1657
Query: 446 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 505
+ ++KL + + +E K K+G + + N+ + ++ + K + +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 506 -DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNT- 563
++ + +S + + ++ L +E K L+ ++ Q + + + T
Sbjct: 1718 LEELEWDMEELSWKEEELN------QEEGKLVEEKKK--LAEEEEALAWQREKLSEEETK 1769
Query: 564 ---ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 620
E E L + K +HKEK +++ G K I E + + + M
Sbjct: 1770 LAQEEELLIQEKE-KLAQHKEKMPEEEE---RLGRKREQLI--EKKMKLAQKRERWINSM 1823
Query: 621 DKEGKTLKKHKL-KHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE---FWKEN 676
++ L K+K+ ++++ + KK + EKEK + + ++ +++E K+
Sbjct: 1824 EE----LTKNKMILYQKKNLAQEKKNLAQEKEKLAQR------KENLLYNKERLTHSKKQ 1873
Query: 677 FFKSDETEDLF---LNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 733
+ +F L E LT EK++ ++K K + T++K V E + ++++K+ +
Sbjct: 1874 LVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE-TEKKLVQVEDSLAKKQEKLAQ 1932
Query: 734 ESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 792
E K + + ++ K R + K+ + +L M + E + LVE + + K E
Sbjct: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEE-KMRLVEGKETLSKGET-- 1989
Query: 793 KESKEKPEKRSQIKEKDIEK--MERKTFEKEKKIKHEHK------SE--KDKLDLSECVD 842
PE Q K +E+ ERK +EK + HE + SE K KL+ +
Sbjct: 1990 ------PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR 2043
Query: 843 KIKEKDKLYSHHTEKCHKEGEK-SKNTAAIKKT---------DDREKSREKMDR-KHDKE 891
+ + + + K K+ E SK A + K D+R+ ++E++ K +
Sbjct: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103
Query: 892 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITN 951
KER L+ + K +++ + SE +K EK K K R+L K + + +T
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK-KLARKQRKLANKMRRMINKEEKMTE 2162
Query: 952 SKHIQEEKKSSIV-----DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1006
+ K S ++ +G + E LK + + K K+K +D +
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222
Query: 1007 RDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDL 1066
+ ++++ L E +K + SS ++ +E+R ++
Sbjct: 2223 EEHFSEEME-----SLLDELEKQESLSSEEEEEREEEEER-----------------EEE 2260
Query: 1067 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1126
E+ + ++ KE+ + +EK+ + + K K+K+K + E +E S E T++
Sbjct: 2261 EVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Query: 1127 YTKEKQPKDAVSNRSQSVDTKNVM 1150
+ E++ +++ S + K ++
Sbjct: 2321 LSDEEEEEESCSLEEEVDREKEIL 2344
Score = 67.4 bits (163), Expect = 1e-10
Identities = 157/730 (21%), Positives = 296/730 (40%), Gaps = 152/730 (20%)
Query: 548 SSEMSLQPDLVRYDNTESEFLP---ESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 604
S +MS +P L+ D + +E P E +SV S S + ++ EK +K
Sbjct: 1108 SKQMSTEPGLLE-DESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISK---- 1162
Query: 605 DHSPTFENSDCTLKKM----DKEGKTLKKHKLKHKEREKEKHKKEIEGE-----KEKYKT 655
DH TLK++ DK K KLK K ++K K K I E E+ T
Sbjct: 1163 DHIAL------TLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVT 1216
Query: 656 KD--------SAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI 707
K S +RS D W+++ + + L + + + E
Sbjct: 1217 KKVKIQGRGASGISGRRSTAGDGSSWRDDLCRL-----MALRISGSQTKMSENLNAELVT 1271
Query: 708 KDDKSTKEKHVSKERNFKEERDKIKKES----------------------EKSFREEKIK 745
+ ++H S E F+E +KKES E + RE+ I+
Sbjct: 1272 FAQEMLVDRHPSWEL-FQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQ 1330
Query: 746 DLKEE----RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI--------- 792
+ +E +E +P +++ + +GL E ++ ++K +K I
Sbjct: 1331 GVTQEVIRHKEVMPREEEQ-----AQKKARDMLGLE--ETQVILKKGKKVIFLEPGNVTM 1383
Query: 793 -KESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDK------- 843
KE +K EK++ K K RK +KE+K+ K + + K++ D+SE V++
Sbjct: 1384 GKEISKKEEKKTFQKS---PKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440
Query: 844 -IKEKDKLYSHHTEKCHKE------------GEKSKNTAAIKKTDDRE--KSREKMDRKH 888
+K++ KL ++ GE K+ A K+ ++ + EK+ +
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500
Query: 889 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSR---DKE 945
+K PE+E + + +K E+ + +N SKS++ + K+++ ++E SR +KE
Sbjct: 1501 EKLSPEEE--MLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
Query: 946 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGK--EKDKK--- 997
+HIQEE K + + +A+ EK + +E+ ++E L + + ++++K
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618
Query: 998 --------DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK---DTRPKEKR 1046
D+++ + + + K++ KL EA+K K +K +E++
Sbjct: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
Query: 1047 LVNDDLMQTSFERMLSLKDLEIEQ------WHKKH-----------KEKIKQKEKERLRN 1089
L + +L+ K E+ Q W +K E++ KE+E +
Sbjct: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
Query: 1090 RNCL---ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEK--QPKDAVSNRSQSV 1144
L + K+ ++E+ E ++E T+ E KEK Q K+ + + +
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
Query: 1145 DTKNVMTLGK 1154
K + K
Sbjct: 1799 GRKREQLIEK 1808
Score = 65.9 bits (159), Expect = 4e-10
Identities = 111/508 (21%), Positives = 222/508 (43%), Gaps = 58/508 (11%)
Query: 579 HKEKSKHQKDFHLEFGEKSNA--KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 636
+KE+ H K ++ K KI + + + +KK +K +T KK L E
Sbjct: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK--LVQVE 1920
Query: 637 REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 696
K ++++ EK K + + + ++ + + + KE + E + L E +
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRL---AEEKMRL 1977
Query: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 756
+E K L K + S + K E+ E K+ E + E++I L E I
Sbjct: 1978 VEGKETLSKGETPETSRQRKMTQVEQELFER--KLSLEEKILLHEDRI--LAMEESEIAK 2033
Query: 757 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE------------KPEKRSQ 804
K EFT ++ L +++ I+K+E KE + + E++
Sbjct: 2034 GK-LEFTRGQRIFVQGQRKLAKASRKL-IKKRESLSKEPAKLNKILKALQKLTRDERKLT 2091
Query: 805 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE- 863
+E + KM+R F KE+++ E+ KLD+ E D +++ +L + K+ +
Sbjct: 2092 QEEIKMTKMKRALFVKERRLS----IEQSKLDIKEW-DFSEKRSELTKDEKKLARKQRKL 2146
Query: 864 KSKNTAAIKKTDDREKSREKMDRKH------DKEK---------PEKERHLAESKEKHL- 907
+K I K + + K+ RKH D+E+ P +R + KE
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206
Query: 908 ---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 964
EK + Q D E SE+ ++E + LD+ EK +ES++ + +EE++
Sbjct: 2207 DKPKEKFSSQVDEVE---SEEHFSEEMESLLDELEK---QESLSSEEEEEREEEEEREEE 2260
Query: 965 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK-HKDKIQINSLLKLK 1023
+ + + E+ +E + + K + K+K KK+K + +E+++ ++K +I S + +
Sbjct: 2261 EVREEEEERK-EEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETE 2319
Query: 1024 SEADKPKPKSSPASKDTRPKEKRLVNDD 1051
S +D+ + + S + ++ +EK ++ +
Sbjct: 2320 SLSDEEEEEESCSLEEEVDREKEILKKE 2347
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 98.6 bits (244), Expect = 6e-20
Identities = 97/451 (21%), Positives = 212/451 (47%), Gaps = 43/451 (9%)
Query: 580 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 630
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 631 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 689
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400
Query: 690 MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 749
E E+K + ++ + +K +EK +E E+ +KI++ EK +EKI++ +E
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 458
Query: 750 ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 806
+R E I + + M EE I E+E I +QE+ + +EK ++ +I+
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEEKMWRQEEKIHEQEKIR 514
Query: 807 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
E++ + + + + +E+KI+ + + + K + E +KI+++++ EK H + EK +
Sbjct: 515 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 867 NTAA---------------IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK--HLME 909
I++ +++ + +E+M ++ +++ E+E + E +EK E
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634
Query: 910 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 969
K +Q + + + + +EK RE ++ + ++++ QEEK + +
Sbjct: 635 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE-------QEEKMCEQEEKMQE 687
Query: 970 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1000
Q EK +EK ++ ++ +EK ++ ++
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 96.7 bits (239), Expect = 2e-19
Identities = 111/515 (21%), Positives = 240/515 (46%), Gaps = 48/515 (9%)
Query: 638 EKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 696
+K+K + IE E K +D+ EL R+ D E ++N ++ + L
Sbjct: 248 QKKKADRYIE---ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ----------LV 294
Query: 697 LEKKSKLEKNIKDDKSTKE--KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 754
+KS+++ N+K+ K E K + ++ + E D + KE + + + + + E N
Sbjct: 295 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 755 PTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI---KEKDIE 811
+ E I+E + E+E I +QE+ I+E +EK ++ ++ KE+ +
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEE-KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413
Query: 812 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 871
+ E +EKE+K++ + + +K E + +++EK H EK ++ EK + I
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEK---EEKIRELEEK----MHEQEKIREQEEKRQEEEKI 466
Query: 872 KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 931
++ + R++ KM R+ +K + E+E + E +EK M ++ ++ E + E+ K +E+
Sbjct: 467 REQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEK--MWRQEEKIHEQEKIREEE-KRQEQ 522
Query: 932 DRELDKKEKSRDKESINITNSK-HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 990
+ ++EK R++E I K H QEEK + Q EK +EK D+ K +
Sbjct: 523 EEMWRQEEKIREQEEIWRQKEKIHEQEEKI-------RKQEEKMWRQEEKMHDQEEKIRE 575
Query: 991 GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVND 1050
+EK + ++ R +E + + +I ++ E ++ K +EK +
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE---------KMGEQEEKMCEQE 626
Query: 1051 DLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTES 1110
+ MQ E+M ++ EQ K +++ K +E+E + ++ ++++ +
Sbjct: 627 EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686
Query: 1111 KNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1145
+ +E R + ++ + + +Q ++ + + ++
Sbjct: 687 EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 91.7 bits (226), Expect = 7e-18
Identities = 76/358 (21%), Positives = 182/358 (50%), Gaps = 25/358 (6%)
Query: 618 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 677
K ++E K ++ + ++ EK + ++E+ EKE+ + ++ + R+ +E
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ--EEMM 433
Query: 678 FKSDETEDLFLNMEHESLTL---EKKSKLEKNIKDDKSTKEKHVS---KERNFKEERDKI 731
++ +E HE + E+K + E+ I++ + +E+ +E +E+ +KI
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493
Query: 732 KKESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEK 790
+++ EK +R EEKI + ++ RE + E M EE I ++ +I +Q++
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKI-----REQEEIWRQKE 543
Query: 791 HIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKE 846
I E +EK K+ + + EKM E K E+E+K+ + E K + + + E +KI+E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 847 KDKLYSHHTEKCHKEGEK-SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905
++++ EK ++ EK + +++ +++ + +E+ R+ +K+ E+E + E +E+
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-QEE 662
Query: 906 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963
+ E++ K + E ++ K +E++ ++ ++E+ ++ + + + +E + +
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 58.9 bits (141), Expect = 5e-08
Identities = 87/492 (17%), Positives = 209/492 (42%), Gaps = 61/492 (12%)
Query: 355 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 411
R+ + E+ KE + ++ + EK+ + K K+K R +L ++ + L
Sbjct: 272 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 331
Query: 412 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 466
+ S S + + +++ Q ++E + E K + ++ + + K +E +E
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 467 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 526
+E+E K + + + EK R + + K++ + K K
Sbjct: 392 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK---- 439
Query: 527 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 586
+ E + +QE + E ++ R + E++ + ++ + K + + +
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEE 498
Query: 587 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK--EKHKK 644
K + E KI++E+ E +K+ ++ + ++ + H++ EK ++ +K
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 645 EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLE 704
E++ + ++ +E + V E +E K E E+ E E +T E++ K+
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI--REQEEMTQEQEEKMG 616
Query: 705 KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTS 764
+ +EK +E +E+ +K++++ EK +E K ++E+ E I
Sbjct: 617 EQ-------EEKMCEQEEKMQEQEEKMRRQEEKIREQE--KKIREQEEKIR--------- 658
Query: 765 LGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PEKRSQIKEKDIEKMERKTFEKE 821
E+E +++QE+ + E +EK E++ Q +E+ + + E K +E+E
Sbjct: 659 ---------------EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703
Query: 822 KKIKHEHKSEKD 833
+++ + + ++
Sbjct: 704 VRLRQQEEKMQE 715
Score = 42.7 bits (99), Expect = 0.004
Identities = 59/317 (18%), Positives = 134/317 (42%), Gaps = 23/317 (7%)
Query: 819 EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 873
E I H S K +L + + + + K + E+ KE E +NT ++
Sbjct: 220 EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 279
Query: 874 TDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYSKSEKGKN 928
++ ++ + + EK E + ++ E K K L+ ++ Q++ K + +
Sbjct: 280 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 339
Query: 929 KEKDRELDKKEK----SRDKESINITNSKHIQE--EKKSSIVDGNKAQHEKPLSLKEKTK 982
+ ++++ E ++ +E + IQE EK + + Q EK +EK +
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 399
Query: 983 DEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRP 1042
+ + +EK ++ +++ KE K + Q + + + + + + K K
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 456
Query: 1043 KEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEK 1102
+EKR + + + + K E+ ++ +EKI+++E++ R E KI ++EK
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ----EEKIHEQEK 512
Query: 1103 TKHTPTESKNKELTRSK 1119
+ + +E+ R +
Sbjct: 513 IREEEKRQEQEEMWRQE 529
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 98.6 bits (244), Expect = 6e-20
Identities = 230/1127 (20%), Positives = 473/1127 (41%), Gaps = 147/1127 (13%)
Query: 256 QANKHGERPVDVAET-----EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 310
Q ++G VDV + + E+ K E P SD + D +++
Sbjct: 233 QRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL----------- 281
Query: 311 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 370
ET + + + + K + S ++ + E + + +D+R L++ ++ ++ A
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER--LQELEKIKDLHMA 339
Query: 371 EKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKK--ISTSCSVIPE--T 426
EKT L + A K+ + ++ ++ + T+ E L+ K+ I+ S I + T
Sbjct: 340 EKTKLITQLRDA---KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 427 SNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKE-NQELKQEKEGKENTRITNLTVNTG 485
+++ +KE E ++++ L K +E ++LK E + + T
Sbjct: 397 QGEELREQKE---KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT---------- 443
Query: 486 LDCSEKTREEG--NFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTC 543
EKT EE + ++ S + + S+ + L EK+ +QE TK
Sbjct: 444 ---IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500
Query: 544 LSPGSSEMSLQPDL-VRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEK-----S 597
+ E Q + V + ++SE+L K + KE+ + LE +K S
Sbjct: 501 QT---REREFQEQMKVALEKSQSEYL------KISQEKEQQESLALEELELQKKAILTES 551
Query: 598 NAKIKD-----EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK 652
K++D E + + +L+K +E K K H E EK KH KEI EK
Sbjct: 552 ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611
Query: 653 YKTK-DSAKELQRSVEFDR-EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD- 709
+KT+ +S K Q ++ ++ + K+ + E E E+L +K+ + +I++
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 710 DKSTKEKHVSKE---RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 766
++ T EK K+ + E ++ K K EE++ LK++ + + + +++
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHK--LEEELSVLKDQTDKMKQELEAKMDE-Q 728
Query: 767 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 826
+ ++ + + E E+ I++ EK +K+ + E + ++K +++ + E IK
Sbjct: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 827 ---EHKSEKDKLDLSECVDK-IKEKDKLYSHHTEKCHKE--GEKSKNTAAIKKTDDREKS 880
E + KLD+ + E+ K Y + ++ +++ K+ + E
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 881 REKMDRKHDKEKPEKERHLAE-SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE---LD 936
++ + + D K + + + + K+ ME+K K SK E G NKE+++ L
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG-NKEQEQTKQILV 907
Query: 937 KKE------KSRDKESINITNSKHIQEEKKSSIVDGN-----KAQHEKPLSLKEKTKD-- 983
+KE + K+ I I K +E I++ K Q +K +K+K K+
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 984 EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1043
E LK ++ K K+++ K+K Q N+ + ++A+ + + +T K
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEK-QFNAKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 1044 E---------KRLVNDDLMQTSFERMLSLKDLEIEQWHK---KHKE----KIKQK----- 1082
E +R +ND + + +E+ L+ + E+++ H+ + KE ++KQK
Sbjct: 1027 EQIESLTEVHRRELNDVI--SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG 1084
Query: 1083 -EKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRS 1141
EKE + N+ LK +E K T ++ +E + KS+ V E + K +
Sbjct: 1085 CEKEEM-NKEITWLK---EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL---- 1136
Query: 1142 QSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPR 1201
+ ++ +L +++F+ + + +E +K +S + + + S ++
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
Query: 1202 PPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTS 1261
+E D LE + + + K+ AL E + + L ++ +R+S
Sbjct: 1197 KSLE---DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 1262 HLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESN 1308
R++ V++ LI + C+ + E Q + ++EE N
Sbjct: 1254 QHRTTKVKEALLI----------KTCT----VSELEAQLRQLTEEQN 1286
Score = 97.4 bits (241), Expect = 1e-19
Identities = 184/933 (19%), Positives = 380/933 (40%), Gaps = 118/933 (12%)
Query: 254 PFQANKHGERPVDV-AETEELELLLKREVPLSDDDESYTDSEEAQ-------SVNPSSVD 305
P QA+ + P + + T L P + ++ + +++ Q S+ S +
Sbjct: 22 PAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIK 81
Query: 306 ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE 365
E++ + K+SL+ S + ++ L S+ ++ D D E ++ + L KEQ +
Sbjct: 82 ESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQ 141
Query: 366 NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV--- 422
E++ + + + +++ +++ ++ ++S D+ + ++ +
Sbjct: 142 RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQ 201
Query: 423 ----IPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRIT 478
+ E ++ ++ K +Y +S Q +K++L+N N + LK + + +
Sbjct: 202 AKKHLQEEFDASLEEKDQY-ISVLQTQVSLLKQRLRNGPMNVD--VLKPLPQLEPQAEVF 258
Query: 479 NLTVNTGLDCSEKTREEGNFRKSFSP-----KDDTSLHLFHISTGKSPKHSCGLSEKQST 533
N D E E+G K+ K +L T +S K C L +
Sbjct: 259 TKEENPESD-GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 534 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE--SEFLPESSSVKSCKHKE-----KSKHQ 586
L+++ L E+ DL + T+ ++ + ++ + + ++K Q
Sbjct: 318 ALQEQ-----LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 587 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 646
LE E+ A+++ +K+M +G+ L++ K K + E+ +K +
Sbjct: 373 MHETLEMKEEEIAQLRSR------------IKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 647 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME-----HESLTLEKKS 701
T +E +R ++ + + + K+ E E + L E E + + KKS
Sbjct: 421 -------STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473
Query: 702 ------KLEKNIKDDKSTKEKHVSK-----ERNFKEERDKIKKESEKSFREEKIKDLKEE 750
KL+K + + + KE+ ++K ER F+E+ ++S+ + KI KE+
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQ 531
Query: 751 RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI--KEK 808
+E++ A+EE L L +K I E + K +E R++I E
Sbjct: 532 QESL--------------ALEE---LELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 809 DIEK--MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
+EK E K K+ + E + K +++ V+K K + + H + E
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE---KL 631
Query: 867 NTAAIKKTDDREKSREKMDRKHDKEKPEKE----RHLAESKEKHLMEKKNKQSD----NS 918
+ + EK REK +++ + +KE H+ E EK L + KQ++ +S
Sbjct: 632 QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
Query: 919 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 978
E S+ K ++K + EL + DK + Q+ VD +HE +
Sbjct: 692 ELSEVLKARHK-LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRT 750
Query: 979 EKTKDEPLKTPD--GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1036
EK + + + KE+DK K+ + E + K L + ++ D + S
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 1037 SKDTRPKEKRL--VNDDLMQTSFERMLSLKDLEIEQWHKK--------HKEKIKQKEKER 1086
+ T+ E++L + L+ ER+L K + + KK HK +++ ++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 1087 LRNRNCLELKIKDKEKTKHTPTESKNKELTRSK 1119
+ + +E K+K + + E NKE ++K
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Score = 85.9 bits (211), Expect = 4e-16
Identities = 245/1232 (19%), Positives = 504/1232 (40%), Gaps = 188/1232 (15%)
Query: 42 KIERSDVSKEM-KEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPV 100
KI+ D+ +++ K+ S M++K+ S + +S E E+++TK+ K++ +
Sbjct: 860 KIQVQDLMQQLEKQNSEMEQKVK-----SLTQVYESKLEDGNKEQEQTKQILVEKENMIL 914
Query: 101 SILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNE 160
+ G ++K++ +L Q + N +T ++ ++ +KV ++ +
Sbjct: 915 QMREG----QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE------KKMEKVKQKAK 964
Query: 161 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 220
+ L + + K KEL + ++ K+ + N ++A+ A +D
Sbjct: 965 EMQETLKKKLLDQEAKLKKELENTALELSQKE--------KQFNAKMLEMAQANSAGISD 1016
Query: 221 VNTQGLDDDTPLHDSASSGHR----DIVKLLLRHGGNPFQANKHGERPVDVAETEELELL 276
++ + +S + HR D++ + + K ++ ++ E E++L
Sbjct: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEK---------KLNQQAEELQEIHEIQLQ 1067
Query: 277 LKREVPLSDDDESYTDSEEAQSVNPSSV---DENIDSETEKDSLICESKQ-------ILP 326
K + + E + +N +E + +T + L + KQ +
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 327 SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE-AEKTHLFAKQEKAFYP 385
+T L + L++ E + + N + ++ + K +E++ + +E T ++ F
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF-- 1185
Query: 386 KSFKSKKQKPSRVLYSST----ESSDEEALQ----------------NKKISTSCS---- 421
+S KS +K ++ L + + S+E A+Q N+ I+ S S
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
Query: 422 VIPETSNSDMQTKKE-----YVVSGEHKQKGKVKRKLKNQNK-NKENQELKQEKEGKENT 475
++ S+ +T K + + ++++ + QN N Q+ + E KEN
Sbjct: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN- 1304
Query: 476 RITNLTVNTGLDCSEKT---REEGNFRKSFSPKDDTSLHLF-HISTG-----------KS 520
+I ++ + +EK +E GN +++ S K+ L +S K
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 521 PKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS---- 576
K KQ T L + + +S E ++ +YD + E L + +
Sbjct: 1365 KKVEISSLSKQLTDLNVQ-LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423
Query: 577 -CKHKEKSKHQ-KDFHLEFGE-KSNAKIKDEDHSPTFENSDCTLKKMDKEGK------TL 627
K K + Q D+ +F E K A+ + H T + L+ KE L
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 628 KKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLF 687
K +L + + + K E+E +K K + K+S E + K + E ED
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE---------LKSQTARIMELED-- 1532
Query: 688 LNMEHESLTLEKKSKLEKNIKDDKSTKEKH-VSKERNFK---EERDKIKKESEKSF--RE 741
++ +++ +E +++ KN K + K V K ++F+ EE+D KE+E+ E
Sbjct: 1533 -HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
Query: 742 EKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK 801
++ +K E E K+ E +L + + EE L +E ++ E K + ++ +K
Sbjct: 1592 NQVYSMKAELET--KKKELEHVNLSVKSKEEE--LKALEDRLESESAAKLAELKRKAEQK 1647
Query: 802 RSQIKEKDIEKMERKTFEKEKKIKHEHKSE-KDKLDLSEC-VDKIKEKDKLYSHHTEKCH 859
+ IK++ + +ME K E+ KK H SE KL E V ++EK K +
Sbjct: 1648 IAAIKKQLLSQMEEKE-EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 860 KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE 919
+KN AA + ++ + S+ + + ++++ +R+L E KEK L+++ ++ + +
Sbjct: 1707 IVPRSAKNVAAYTEQEEAD-SQGCVQKTYEEKISVLQRNLTE-KEK-LLQRVGQEKEETV 1763
Query: 920 YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEE-----KKSSIV-------DGN 967
S E + L K E + K+ + + H+QEE KK S++ +G
Sbjct: 1764 SSHFE--MRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG 1821
Query: 968 KAQHEKPLSLKEKTKDEPLKTPDGKE-----KDKKDKDIDRYKERDKHKDKIQINSL--- 1019
K + +L E D+ KT KE ++K K++D R K ++++ L
Sbjct: 1822 KNNIQAKQNL-ENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 1020 ------LKLKSEADKP----KPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLE-- 1067
L+ +KP + + SK + K L N + E L+ + E
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 1068 ------------IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1115
+ K+H+++++ +KE + R E KIK +++ S K+L
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER---EEKIKQEQEDLELKHNSTLKQL 1997
Query: 1116 TRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1147
R ++++ + + N++Q V+ +
Sbjct: 1998 MREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
Score = 83.2 bits (204), Expect = 2e-15
Identities = 170/851 (19%), Positives = 336/851 (39%), Gaps = 119/851 (13%)
Query: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 406
+I ++ ++ L+KE + + +EK + +K S+ ++ +
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL------SENINAVTLMKEELKEK 1365
Query: 407 DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ---------- 456
E K T +V + NS ++KE +S KQ + K +L +Q
Sbjct: 1366 KVEISSLSKQLTDLNV--QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423
Query: 457 ----------------NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRK 500
NK E ++ Q + + + L + L E ++
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 501 SFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRY 560
D + F G+ +K K+ + +T L ++ + D +
Sbjct: 1484 LKEELDQQNKR-FDCLKGEME------DDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 561 DNTESEFLPES----SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD-EDHSPTFENSDC 615
E E L E + K +HKE + + F E GE+ + ++K+ E+ T EN
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQVY 1595
Query: 616 TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKE--------KYKTKDSAKELQRSV 666
++K +++ + K L+ L K +E+E E E E K K + +++ +
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 667 EFDREFWKENFFKSDETEDLFLNM-----EHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 721
E +E + K E+ LN E E LE+K K ++ + + +
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Query: 722 RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV-- 779
+ E+ + + + EEKI L+ T+K+ +G EE++ H
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNL----TEKEKLLQRVGQEK-EETVSSHFEMR 1770
Query: 780 ----EKEIDIEKQEK----------HIKES-KEKPEKRSQIKEKDIEKMERKT-FEKEKK 823
E+ I +E E H++E +EK +K S I + +EK K + ++
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN 1830
Query: 824 IKHEHKSEKDKLDLSECV-----DKIKEKDKLYSHHTEKCHKEGE----KSKNTAAIKKT 874
+++ + L E KIKE D E E E K + A+++
Sbjct: 1831 LENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
Query: 875 DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD----NSEYSKSEKGKN-- 928
D R K E ++ +++ + HL + K ME ++ + +E K + GK
Sbjct: 1891 DGRNKPTELLEENTEEKS---KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV 1947
Query: 929 -KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK 987
+KD + +KE ++ E + K +E++ I Q ++ L LK + + L
Sbjct: 1948 RLQKDLRMLRKEHQQELEILK----KEYDQEREEKI-----KQEQEDLELKHNSTLKQLM 1998
Query: 988 TPDGKEKDKKDKDIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1046
+ +K+++++ KE +++ L + E ++ K + D + KR
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Query: 1047 LVNDDLMQTSFERMLS-LKDLE--IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1103
++++ E M + ++DL+ +E+ KK+++K++Q+E N +EL+ + +KT
Sbjct: 2059 Y--EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
Query: 1104 KHTPTESKNKE 1114
++SK KE
Sbjct: 2117 T-LISDSKLKE 2126
Score = 68.2 bits (165), Expect = 8e-11
Identities = 137/717 (19%), Positives = 290/717 (40%), Gaps = 131/717 (18%)
Query: 285 DDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEY--EFKD 342
+DD+S + +E S+++ + S+T + I E + + KT +L+E +
Sbjct: 1503 EDDKSKMEKKE------SNLETELKSQTAR---IMELEDHITQKTIEIESLNEVLKNYNQ 1553
Query: 343 DDDEEINKMIDD-RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYS 401
D E +++ +H + K+N + + + + + + K+ K+K +
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 402 STESSDEE--ALQNKKISTSCSVIPETSN--------------SDMQTKKEYVVSGEHKQ 445
S +S +EE AL+++ S S + + E S M+ K+E G
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 446 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDC------SEKTREEGNFR 499
++ KL Q + +E L+++ + E+++ L V E+ +G +
Sbjct: 1674 LSELNTKL--QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 500 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 559
K++ K + + EK + QE +T S Q L++
Sbjct: 1732 KTYEEKISVL------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 560 YDNTESEFLPESSSVKSCKHKEKSKHQKDF-----HLEF-GEKSNAKIKD------EDHS 607
++ E++ + S + + + + K++K H+E G K+N + K +D
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 608 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 667
T + + T + ++++ K L + R+KE H+ E+E KY+ + +++
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLV----RQKEVHRVEMEELTSKYEKLQALQQMDG--- 1892
Query: 668 FDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEE 727
++ TE L N E +S + + KL N++ + E ++ E
Sbjct: 1893 -----------RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA-----E 1936
Query: 728 RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 787
R+K K E ++ ++ L++E + L +++KE D E+
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQ---------------------ELEILKKEYDQER 1975
Query: 788 QEKHIKESKEKPEKRSQI---------------KEKDIEKMERKTFEKEKKIKHEHKSEK 832
+EK IK+ +E E + KE+++E ++T K ++++ E E
Sbjct: 1976 EEK-IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLES 2033
Query: 833 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH---- 888
+ + ++ + KI EKD T K ++E ++ K D + E++ +K+
Sbjct: 2034 HQEETNQLLKKIAEKDDDLK-RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092
Query: 889 -DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944
+E P + + L +K SD SK ++ + +E+ L+ + K +K
Sbjct: 2093 EQEENPGNDNVTIMELQTQLAQKTTLISD----SKLKEQEFREQIHNLEDRLKKYEK 2145
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 98.2 bits (243), Expect = 7e-20
Identities = 191/946 (20%), Positives = 381/946 (40%), Gaps = 139/946 (14%)
Query: 306 ENIDSETEKDSLICES----KQILPSKTPLPSALDEYEFKD--DDDEEINKMIDD-RHIL 358
EN+ +E E+ + E+ KQ L K A + K + ++E+ +M + R
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 359 RKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST 418
+ +Q+K E E E L A+ A ++ L SS S EE + K
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPA------GDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 419 SCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGK-----E 473
+ S ++ S+ + E V +H+ +G V ++ + K + + +EG E
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 474 NTRITNLTVNTGLDCSEKTREEGNFR----KSFSPKDDTSLHLFHISTGKSPKHSCGLSE 529
+L+++T CSE + K FS D+ + +L I K + GL E
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK--ERIAGLEE 1854
Query: 530 -----KQSTPLKQEHTKTCLSPGSSE----MSLQPDLVRYDNTESEFLPESSSVKSCKHK 580
K+ + + T LS S++ LQ ++ + + + E S V K K
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT--KLK 1912
Query: 581 EKSKHQKDFHLE----------------FGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 624
E ++ +KD E + ++A+IK+E +N + ++++E
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEK 1972
Query: 625 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 684
+ L K K K + ++++ ++I+G +++ K AKELQ E KE K E +
Sbjct: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ-------ELLKE---KQQEVK 2022
Query: 685 DLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEKSF 739
L + EK S LE+ +K +S K+ ++KE + + K ++E +
Sbjct: 2023 QLQKDCIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 740 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK-----QEKHIKE 794
+ + D + E + D + + +ES+ + +K+ D+E+ +EKH+KE
Sbjct: 2080 FKVLLDDTQSEAARVLADNLK--LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137
Query: 795 SKEKPEKRSQIKEKDIEKME-----RKTFEKEKKIKHEHKSEKDKL-------------- 835
K EK ++ + + E + T K+ K + + D
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197
Query: 836 --DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP 893
D +D+ K+ ++ +S + +E ++ ++ K R+ S + K + +
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 894 EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953
E ++ + ESK + ++ + K D + G+NKE +L++ ++
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQ------GENKELLSQLEE--------------TR 2297
Query: 954 HIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKD 1012
H+ ++ + A+ E L SLK++ D KE+ + I R +E D
Sbjct: 2298 HLYHSSQNEL-----AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 1013 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1072
K S +L+++ + +S ++ KE+++++ + + E + + E+ Q H
Sbjct: 2353 KF---SYEQLETDLQASRELTSRLHEEINMKEQKIIS---LLSGKEEAIQVAIAELRQQH 2406
Query: 1073 KKH-KEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKE- 1130
K KE +E N E K +KT K + + D++ K
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 1131 ---KQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1173
+ +D + Q ++ +++ S + + L + +EN K
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHL-----SIILEKDQLIQEAAAENNK 2507
Score = 86.7 bits (213), Expect = 2e-16
Identities = 194/996 (19%), Positives = 393/996 (39%), Gaps = 132/996 (13%)
Query: 346 EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 405
++I + + I RKE KEN+ E+ L + + KS S+V + E
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSL----ARGTIERLTKSLADVESQVSAQNKEK 1534
Query: 406 S--------------------DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 445
D L+N+ +S+SC + + K++ V E +
Sbjct: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
Query: 446 KGKVKRKLKNQNKNKENQE------LKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 499
K+ + Q K+KE Q+ E E RI ++ EK G R
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR---QEKQELYGKLR 1651
Query: 500 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 559
+ + K +T L +E++ +K++ K S + L+ +
Sbjct: 1652 STEANKKETEKQLQE-------------AEQEMEEMKEKMRKFAKSKQQKILELEEE--- 1695
Query: 560 YDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKK 619
D +E P + K C +E SNA +K+E E +
Sbjct: 1696 NDRLRAEVHPAGDTAKEC-------------METLLSSNASMKEE-----LERVKMEYET 1737
Query: 620 MDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFK 679
+ K+ ++L K E E + K +IEG K ++ ++ E +
Sbjct: 1738 LSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS---I 1793
Query: 680 SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-------RNFKEERDKIK 732
ETE E +SL++ + +++ KS VSK+ N+ ++ D++K
Sbjct: 1794 PGETE------EQDSLSMSTRPTCSESVPSAKSANPA-VSKDFSSHDEINNYLQQIDQLK 1846
Query: 733 K-----ESEKSFREEKIKDLKEERENIPTD---KDSEFTSLGMSAIEESIGLHLVEKEID 784
+ E EK +E + L+ E+ + + KD E L + ++ +++E+
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906
Query: 785 -IEKQEKHIKESKEKPEKR--SQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 841
+ K ++ +E K+ E+R +Q+ E + + +IK+E E + +L +CV
Sbjct: 1907 RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE-LLESEMKNLKKCV 1965
Query: 842 DKIKEKDKLYSHHTEKCHKEGEK---SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 898
+++E+ + K E K K A K+ ++ ++E + +K++ K+
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
Query: 899 LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE-LDKKEKSRDKESINITNSKHIQE 957
+ + + + E+ ++E K+ E +E L + + R K + + K + +
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 958 EKKSS---IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1014
+ +S ++ N ++ S KE K + + + E+ + + KE+ ++K+
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 1015 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE------RMLSLKD--- 1065
K+ E + + + KD KE + + ++L T + M SL+D
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKD---KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRD 2202
Query: 1066 ---LEIEQWHKKHKEKIKQKEKE-RLRNRNCLELKIKDKEKTKHTPTESKN-KELTRSKS 1120
E ++W +K + I+ KE+E RL+ NC LK + ++ + H N L K
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 1121 SEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENE----KPGL 1176
+ A T E Q + V + Q + + + L ++ + +S N + E+E K L
Sbjct: 2263 IWESKAQT-EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321
Query: 1177 SSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALH 1236
+ S S+ + + + ++ +S F E E+ + S+ + + +
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEADIQ-NSKFSYEQLETDLQASRELTSRLHEEINMK 2380
Query: 1237 ERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVK 1272
E+++ SL E A +++ + LR +++K
Sbjct: 2381 EQKIISLLSGKEE-----AIQVAIAELRQQHDKEIK 2411
Score = 70.5 bits (171), Expect = 2e-11
Identities = 190/912 (20%), Positives = 356/912 (39%), Gaps = 148/912 (16%)
Query: 291 TDSEEAQSVNPSSVDENIDSETEK-DSLICESKQILPSKTPLPSALDEYEFKD-DDDEEI 348
T+ + Q+ ++I ETE+ DSL ++ P + + KD +EI
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
Query: 349 NKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDE 408
N + L KE+ E E +K K F + L S + D
Sbjct: 1836 NNYLQQIDQL-KERIAGLEEEKQKN------------KEFSQTLENEKNTLLSQISTKDG 1882
Query: 409 EA-----------LQNKKISTSCSVIP---ETSNSDMQTKKEYVVSGEHKQKGKVKRKLK 454
E L N++I S + ET+ + +E +++ + G + +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942
Query: 455 NQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFH 514
+ + EL + + ++ L EKT+ E RK + K
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQ------- 1995
Query: 515 ISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSV 574
K P + E Q LK++ + LQ D +RY S +V
Sbjct: 1996 -GAQKEPGNKSHAKELQEL-LKEKQQEV--------KQLQKDCIRYQEKISAL---ERTV 2042
Query: 575 KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 634
K+ + + ++ QKD + + A + + L E + LK
Sbjct: 2043 KALEFVQ-TESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 635 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHE- 693
K +E + +K+ ++ + K K +D + L+++ E + K K D +++E
Sbjct: 2102 K-KELQSNKESVKSQM-KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Query: 694 ---SLTLEKKSK----LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 746
+TL KK K L++N+ + + +++RD++ E++K E K D
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW--ERKFSD 2217
Query: 747 LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEKRSQ 804
+ +E K+ + L + SI H+ E +I+I + E K I ESK + E + Q
Sbjct: 2218 AIQSKEEEIRLKEDNCSVLKDQLRQMSI--HMEELKINISRLEHDKQIWESKAQTEVQLQ 2275
Query: 805 IKEKDIEKMERKTFEKE---------------KKIKHEHKSEKDKL-DLSECVDKIKEK- 847
K D + E K + K++ E KS KD+L DLS ++K KE+
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335
Query: 848 ---------------DKLYSHH------------TEKCHKEGEKSKNTAAIKKTDDREKS 880
+ +S+ T + H+E K I +E++
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE-INMKEQKIISLLSGKEEA 2394
Query: 881 RE----KMDRKHDKEKPEKERHLAESKEKHLM---------EKKNKQSDNSEYSKSEKGK 927
+ ++ ++HDKE E E L++ +E++++ +K N+ E K+ K +
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL---METLKTIKKE 2451
Query: 928 NKEKDRELDKKEKS-----RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL---SLKE 979
N ++ +LD KS D++ I + + + ++E S I++ ++ E LKE
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRI-VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 980 KTKDEPLKTPD-GKEKDKKDKDIDRYKERDKH----KDKIQINSLLKLKSEADKPKPKSS 1034
+ + D E K D ++ +Y+E KD Q LL+++ + +K + ++
Sbjct: 2511 EIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS-QQKQLLEVQLQQNK-ELENK 2568
Query: 1035 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDL--EIEQWHKKHKEKIKQ---KEKERLRN 1089
A + + KE N+DL ++ +DL EIE + +Q ++E
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 1090 RNCLELKIKDKE 1101
+LK+K++E
Sbjct: 2629 LYHAQLKVKEEE 2640
Score = 49.3 bits (116), Expect = 4e-05
Identities = 84/411 (20%), Positives = 170/411 (41%), Gaps = 52/411 (12%)
Query: 800 EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 859
E + I++KD++ ++ +E++ ++K +K KL K K + + E+
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA-------KAKLTSLNKYIEEMK 115
Query: 860 KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD-NS 918
+G T E E+ KHDK E+E + + K K L EK+ S +
Sbjct: 116 AQGGTVLPT---------EPQSEEQLSKHDKSSTEEEMEIEKIKHK-LQEKEELISTLQA 165
Query: 919 EYSKSEKGKNKEKDRELDK----KEKSRDKESINITNSKHIQ----EEKKSSIVDGNKAQ 970
+ ++++ + + E+++ K++ ++KE T + E+ +V A+
Sbjct: 166 QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDAR 225
Query: 971 HEKPLSLKEKTKDEPLK--TPDGKEKDKKDKDIDRYKERDKHKDKI-------------- 1014
E + L E DE L+ T E + + K ++ ++H++ +
Sbjct: 226 FETQVRLHE---DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282
Query: 1015 ----QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1070
Q N +L + + + + + + +T +E +++ + + ER LS +L+ E
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342
Query: 1071 WHKKHK-EKIKQKEKERLRNRNCLELKIKDK--EKTKHTPTESKNKELTRSKSSEVTDAY 1127
H + E+ Q + E + LE K K + EKT H + K + +S + D
Sbjct: 343 HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402
Query: 1128 TKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSS 1178
+K Q K+ + +S + L + S LNR P ++E +S
Sbjct: 403 SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453
Score = 48.1 bits (113), Expect = 9e-05
Identities = 105/605 (17%), Positives = 239/605 (39%), Gaps = 78/605 (12%)
Query: 608 PTFENSDCTLKKMDKEG--KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 665
PT S+ L K DK + ++ K+KHK +EKE+ ++ + + + + A Q S
Sbjct: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA---QSS 179
Query: 666 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFK 725
E + F+ M+ + L++K + ++ S + + ++ +
Sbjct: 180 TEMEE----------------FVMMKQQ---LQEKEEFISTLQAQLSQTQAEQAAQQVVR 220
Query: 726 EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 785
E+ + E++ E+++ L + + + T+ + L E L + +D+
Sbjct: 221 EKDARF--ETQVRLHEDELLQLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 786 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 845
+QE E+R+QI + +++ME + ++ E + K L+ E ++
Sbjct: 278 LQQE------LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL--EVA 329
Query: 846 EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHL------ 899
E+ + + E+ H E+ + + + E +++KH E EK H+
Sbjct: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQA--ELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 900 ----------AESKEKHLMEKKNKQSDNSEYSKSE-KGKNKEKDRELDK---KEKSRDKE 945
+ + L++ KN+Q+ S + + + + ++K +E+ + + + E
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 946 SINITNSKHIQEEKKSSIVDGNKA---------QHEKPLSLKEKTKDEPLKTPDGKEKDK 996
+ + T+ + E ++ + N A ++EK L + E LK E +K
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA----ENEK 503
Query: 997 KDKDI------DRYKERDKHKDKIQINSLL-KLKSEADKPKPKSSPASKDTRPKEKRLVN 1049
I +R E D+ +I I + K S A++ + + KE ++
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL 563
Query: 1050 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK-DKEKTKHTPT 1108
++ + E L+ ++ + E + QKE +++ +K+K E T
Sbjct: 564 LEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623
Query: 1109 ESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPR 1168
N+E + + + + + + +S V+ K+ G S + + + +
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 1169 SENEK 1173
E E+
Sbjct: 684 DELER 688
Score = 47.8 bits (112), Expect = 1e-04
Identities = 172/869 (19%), Positives = 313/869 (36%), Gaps = 165/869 (18%)
Query: 454 KNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLF 513
KN + N E+ + +++ L++ T L K E + D
Sbjct: 730 KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTA 789
Query: 514 HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR-----YDNTESEFL 568
H + HS + E +S +K E + L + S Q L+R N ESE L
Sbjct: 790 HDNLLTEQIHSLSI-EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVL 848
Query: 569 PESSSVK--SCKHKEKSKHQKDFHLEFG-------------EKSNAKIKDEDHSPTFENS 613
+ V+ S K +E S+ LE E I+++D T +
Sbjct: 849 EGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF 908
Query: 614 DCTLK---------KMDKEGKTLKKHKLKHKEREKEKHKKEIE-------GEKEKYKTKD 657
T K + E KTLK+ +L R +E K+++E G K+ Y
Sbjct: 909 SMTEKMVQLNEEKFSLGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 658 SAKELQRSVEFDREF---WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD--DKS 712
A ++ + E EF KEN + + + +N + L++ S+LE+ + + D+S
Sbjct: 968 PAGQISKE-ELQHEFDLLKKENEQRKRKLQAALINRKE---LLQRVSRLEEELANLKDES 1023
Query: 713 TKEKHVSKERNFKEERDKIKKE-----------------------------------SEK 737
KE +S+ + E DK KE EK
Sbjct: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
Query: 738 SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI----------------GLHLVEK 781
EE+ + L ++ DK ++ L E + LV++
Sbjct: 1084 LAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Query: 782 EIDI-------------EKQEKHIKESKEKPEKRSQIKEKDIEKME--RKTFEKEKKIKH 826
+ I E +EK + KEK + + +++E + +K EKE+ ++
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203
Query: 827 EHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMD 885
E K +KD + L E D+ ++++ + + +S + + TD +E
Sbjct: 1204 ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESID-GKLPSTDQQESCSSTPG 1262
Query: 886 RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 945
+ K ++ H E +L +SE + + +G + KE +K
Sbjct: 1263 LEEPLFKATEQHHTQPVLESNLCP---DWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319
Query: 946 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK 1005
+ + S E K S E+ L+E+ + L+ K + +
Sbjct: 1320 ELELKVSSTTSELTKKS---------EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370
Query: 1006 ERDKHKDKIQI---NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE-RML 1061
++ ++QI L +L+ + D+ + S +D +L + T + ++
Sbjct: 1371 QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 1062 SLKDL------EIEQWHKKHKEKIKQ--------KEK-----ERLRNRNCLELK-----I 1097
+DL ++E K+H E+IKQ K+K E R + ++ K I
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALI 1490
Query: 1098 KDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSF 1157
KE K + + L R +T + + VS +++ DT LG+ +
Sbjct: 1491 SRKEALKENKSLQEELSLARGTIERLTKSLA---DVESQVSAQNKEKDT----VLGRLAL 1543
Query: 1158 VS---DNSLNRSPRSENEKPGLSSRSVSM 1183
+ D + RS E LSS S+
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESL 1572
Score = 46.6 bits (109), Expect = 2e-04
Identities = 185/966 (19%), Positives = 379/966 (39%), Gaps = 174/966 (18%)
Query: 256 QANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKD 315
+A K + D +++E E+ LK D+ D S++ + NI S E D
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKE-----DNCSVLKDQLRQMSIHMEELKINI-SRLEHD 2260
Query: 316 SLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHL 375
I ESK ++ L + + + ++ E ++++ + RH+ Q + + E+E L
Sbjct: 2261 KQIWESKA--QTEVQLQQKVCD-TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317
Query: 376 FAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKK 435
K + S + K++ + E +QN K S E +D+Q +
Sbjct: 2318 --KDQLTDLSNSLEKCKEQKGNL--EGIIRQQEADIQNSKFSY------EQLETDLQASR 2367
Query: 436 EYVVSGEHKQKGKVKRKLKNQNKNKENQ------ELKQEKEGKENTRITNLTVNTGLDCS 489
E + S H++ ++K+ + KE EL+Q+ + KE + NL
Sbjct: 2368 E-LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD-KEIKELENLL-------- 2417
Query: 490 EKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGS- 548
EE N + K+ + L E T +K+E+ + S
Sbjct: 2418 -SQEEEENI-------------VLEEENKKAVDKTNQLMETLKT-IKKENIQQKAQLDSF 2462
Query: 549 --SEMSLQPDLVR----YDNTESEFLP---------ESSSVKSCKHKEKSKHQKDFHLEF 593
S SLQ D R Y E L + ++ ++ K KE+ + + H++
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS-HMDD 2521
Query: 594 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 653
NAK+ D + E+ + + D + K L + +L+ + + K+ K E KE
Sbjct: 2522 LNSENAKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE-- 2578
Query: 654 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 713
++++ ++L+RS +E E +DL +E +++ + ++ ++++ +
Sbjct: 2579 -SEEANEDLRRSFNALQE----------EKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627
Query: 714 KEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEE 772
H K + +++ + S S +++I +L+EE + +++
Sbjct: 2628 GLYHAQ----LKVKEEEVHRLSALFSSSQKRIAELEEE----------------LVCVQK 2667
Query: 773 SIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 832
+ E E ++K+ KH+ ++ E+ + ++ R E E+K+ K K
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK 2727
Query: 833 ------------------DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK-NTAAIKK 873
+ +E +D++K K + ++G ++ A + +
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787
Query: 874 TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN----SEYSKSEKGKNK 929
T S E+ H EK SK++ L+ ++ D+ +SK+
Sbjct: 2788 TAFSMNSTEENSLSH----LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
Query: 930 EKD---RELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK------ 980
E+D EL+K KS + + + E +S + Q+++ LKE
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2903
Query: 981 --------TKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1032
T+ PLK +E K K +E + ++ + L +L+ E K
Sbjct: 2904 YLQINQEITELHPLKA-QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME------K 2956
Query: 1033 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE-KIKQKEKERLRNRN 1091
SS + R KE+ L+ +S KD ++ +E + + + L+
Sbjct: 2957 SSWEIHERRMKEQYLM-----------AISDKDQQLSHLQNLIRELRSSSSQTQPLK--- 3002
Query: 1092 CLELKIKDKEKTKHTPTESKN----KELTRSK-SSEVTDAYTKEKQPKDAVSNRSQSVDT 1146
++ + + +T +P S+N EL R++ + + + + KE + + SN SQ ++
Sbjct: 3003 -VQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061
Query: 1147 KNVMTL 1152
KN +++
Sbjct: 3062 KNTLSI 3067
Score = 43.9 bits (102), Expect = 0.002
Identities = 215/1158 (18%), Positives = 430/1158 (37%), Gaps = 136/1158 (11%)
Query: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 756
L ++S +E N + +E+ E+ E +D I+++ + ++K + L+EER+
Sbjct: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQL--QQKDEALQEERKAA-- 89
Query: 757 DKDSEFTSLGMSAIEESIGLHLVEKEIDIE-----KQEKHIKESKEKPEKRSQIKEKDIE 811
D++ L + A + L+ +E+ + E +E K +K S +E +IE
Sbjct: 90 --DNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
Query: 812 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 871
K++ K EKE+ I +++ + + E ++ + KE S A +
Sbjct: 148 KIKHKLQEKEELIS-TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206
Query: 872 KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 931
+T E++ +++ R+ D + E + L E + L+ + + +++ + + + K +E
Sbjct: 207 SQT-QAEQAAQQVVREKD-ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEH 264
Query: 932 DRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDG 991
+ L + + D +T ++ + + S + +A+H + E ++E +
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQ-RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323
Query: 992 KEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD 1051
E + ++ + H + +++ LL+ +A + + + K K
Sbjct: 324 MELEVAERKL------SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA----- 372
Query: 1052 LMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESK 1111
M+ +LSL+ E Q + L+++N L+ K+++ + T +
Sbjct: 373 EMEEKTSHILSLQKTGQE----------LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 1112 NKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSEN 1171
++ + KS E++ + + ++++ D N T + + R EN
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482
Query: 1172 EKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIA- 1230
EK L S+ + + + + + +T + + E+ S+ + IA
Sbjct: 483 EKGALLLSSIELEELKAENEKLSSQITL--------LEAQNRTGEADREVSEISIVDIAN 534
Query: 1231 -KSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSM 1289
+S + E D L N S H + + L + E + I + +
Sbjct: 535 KRSSSAEESGQDVL-----------ENTFSQKH---KELSVLLLEMKEAQEEIAFLKLQL 580
Query: 1290 PSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSF-AT 1348
E E +Q + + G+ K +VF +D + N SS A
Sbjct: 581 QGKRAEEADH-----EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
Query: 1349 SPTGASNSKYVSADRNLIKNTAPV---NTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLET 1405
AS + N A V +T D L +G + D LE
Sbjct: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG-------QCHQDELER 688
Query: 1406 LSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLS-LRQTELPGNSCAQDPASFMP 1464
L S I + E + K L E A +S L Q A + +S
Sbjct: 689 L--------KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSS--- 737
Query: 1465 PQQPCSFPSQSLSDAESISKHMSLSYVANQEPGI--LQQKNAVQIISSALDTDNESTKD- 1521
+F + S + +S+ LS V + L+ A LD ++++ D
Sbjct: 738 -----AFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
Query: 1522 --TENTFVLG-DVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDA-STQL 1577
TE L + + D + V + E++ + L S+ S+
Sbjct: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Query: 1578 NTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMP 1637
+ SK+ S + + E T + EK+ +E+L T + D + E++ M
Sbjct: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT-IEEKDQQVTEISFSMT 911
Query: 1638 KG--NLNEQ------DPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQ 1689
+ LNE+ + K E L E+ + +Q + + + EM GQ
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 1690 LVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIR 1749
+ K EL+ + K EN+ QR + +A + N+ + + L E + + I
Sbjct: 972 ISKEELQHEFDLLKKENE--QRKRKLQA-ALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 1750 LTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSER 1809
L+E + ++ ++ K + EK S K EI+ Y +
Sbjct: 1029 LSETERGEVEEDKENK---------------EYSEKCVTS--------KCQEIEIYLKQT 1065
Query: 1810 -ANPYFEYLHIRKKIEEK 1826
+ E HIRK +EEK
Sbjct: 1066 ISEKEVELQHIRKDLEEK 1083
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 98.2 bits (243), Expect = 7e-20
Identities = 162/896 (18%), Positives = 350/896 (39%), Gaps = 121/896 (13%)
Query: 301 PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 360
P S +EN++ ET +D ++ I Y++ + E+ + R +++
Sbjct: 135 PESEEENVEWETNRDD--SDNGDI------------NYDYVHELSLEMKRQKIQRELMKL 180
Query: 361 EQ-----------RKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEE 409
EQ +KE PE ++ L KS KS K+K S S+++ +
Sbjct: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLR---KSSKSPKRKSSPKSSSASKKDRKT 237
Query: 410 AL---------QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNK 460
+ +N K + S P T + ++ + ++K+K KVK +++ + +
Sbjct: 238 SAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR-- 295
Query: 461 ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKS 520
+GK+ R E+ RE+ + +S SP H S S
Sbjct: 296 ---------DGKDRGRDF-----------ERQREKRDKPRSTSPAGQ------HHSPISS 329
Query: 521 PKHSCGLSEKQSTPLKQEHT-----KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVK 575
HS S QS Q H+ K SP S + +L P L R S S S+
Sbjct: 330 RHHS---SSSQSGSSIQRHSPSPRRKRTPSP-SYQRTLTPPLRR-----SASPYPSHSLS 380
Query: 576 SCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHK 635
S + K+ + E G + + + H E + T K D+E + ++ + +
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTS-QSHDRRHERREDTRGKRDREKDSREEREYEQD 439
Query: 636 EREKEKHKKEIE-----GEKEKYKTKD-----SAKELQRSVEFDREFWKENFFKSDETED 685
+ H+ + E ++ T+D +++++ S E R++ ++ D +
Sbjct: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREM-RDYSRDTKESRDPRDS 498
Query: 686 LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 742
H+ E + K ++ +S H+ +E + E R++ + ES R +
Sbjct: 499 RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND 558
Query: 743 KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKR 802
++ + +P + + + H D + E PE+
Sbjct: 559 RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYH------DSWETRSSYPERDRYPERD 612
Query: 803 SQIKEKDIEKMERKTFEKEKKIKHE----------HKSEKDKLDLSECVDKIKEKDKLYS 852
++ + +D ER+ E++++ E H+ D+L+ E ++ + D++
Sbjct: 613 NRDQARD-SSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE-RRVDRVDD 670
Query: 853 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
E+ + + + ++ +RE+ RE+ + + + +ER KE+ ++
Sbjct: 671 RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730
Query: 913 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 972
+ D + E+ + KE++RE +++E+ R++E + + E++ + + + +
Sbjct: 731 RDHDRERERERERDREKEREREREERERERERER---ERERERERERERARERDKERERQ 787
Query: 973 KPLSLKEKTKDEPLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLKSEADKPKP 1031
+ K+K +D+ + + +D+ +D D K + +++++ + K +
Sbjct: 788 RDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPD 847
Query: 1032 KSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1091
+ S D + ++ RL++ +++ R LS L ++ + +E K + KE R
Sbjct: 848 SDAYNSGDDKNEKHRLLS-QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
Query: 1092 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1147
EL KEK + + E+ S D + S+R+ + K
Sbjct: 907 EQEL----KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKK 958
Score = 87.4 bits (215), Expect = 1e-16
Identities = 143/799 (17%), Positives = 317/799 (39%), Gaps = 138/799 (17%)
Query: 373 THLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQ 432
+H + ++ P +S ++ R + T S + + ++ + + S + +
Sbjct: 376 SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE 435
Query: 433 TKKEYVVSGEHKQKGKVK--RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSE 490
+++ S +H+ + + R ++ ++ +EL+ ++ +++ + D S
Sbjct: 436 YEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR--------DYSR 487
Query: 491 KTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP-----LKQEHTKTCL- 544
T+E + R S S +D H + G+ ++S L++E ++T +
Sbjct: 488 DTKESRDPRDSRSTRD---AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
Query: 545 --SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIK 602
S S ++ D + LPE S + + + H + + ++ +
Sbjct: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGS-RGSRGSQIDSHSSNSNYHDSWETRSSYP 603
Query: 603 DEDHSPTFENSDCTL----------------KKMDKEGKTLKKHKLKHKEREKEKHKKEI 646
+ D P +N D ++ D+ + +H+ ++ E E+++ ++E
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
Query: 647 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 706
++ + + A+E R E DRE +E E E
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERER--------------ERE------------- 696
Query: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 766
+D + KE+ + +ER + ER++ E E+ ++ +D ERE
Sbjct: 697 -RDREREKERELERERARERERER---EKERDRERDRDRDHDRERER------------- 739
Query: 767 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 826
E+E D EK+ + +E +E+ +R + +E++ E+ + E++K+ +
Sbjct: 740 -------------ERERDREKEREREREERERERERERERERERERERERARERDKERER 786
Query: 827 EHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK 883
+ E K + D E ++I+E H E+ K+ +++ + + +++ R +
Sbjct: 787 QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
Query: 884 MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRD 943
++ + E+H S+ + ++++ S ++ +G+ KE+DR+ ++KE SR
Sbjct: 847 DSDAYNSGDDKNEKHRLLSQV--VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRR 904
Query: 944 KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD-------EPLKTPD-GKEKD 995
E + ++K S VD + Q E S + + +D E +T D +++
Sbjct: 905 YEEQEL--------KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDEN 956
Query: 996 KKDKDIDRYKERDKHKDKIQI--NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLM 1053
KK I + + K +D + I ++ + PK K K K+ D
Sbjct: 957 KKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDS-- 1014
Query: 1054 QTSFERMLSLKDLEIEQWHKKHK----EKIKQKEK--ERLRNRNCLELKIKDKEKTKHTP 1107
+ D E Q KK + I KE+ E +N + ++D +K + T
Sbjct: 1015 --------DISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI---LEDSQKKEDTA 1063
Query: 1108 TESKNKELTRSKSSEVTDA 1126
+ E + +EVT+A
Sbjct: 1064 FSDWSDEDVPDR-TEVTEA 1081
Score = 57.0 bits (136), Expect = 2e-07
Identities = 101/543 (18%), Positives = 204/543 (37%), Gaps = 63/543 (11%)
Query: 705 KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDS--EF 762
KN + D T+ + +RN +E ++KES + EK +D+K +E P ++ E+
Sbjct: 90 KNKRQDVDTEPQ----KRNTEESSSPVRKESSRGRHREK-EDIKITKERTPESEEENVEW 144
Query: 763 TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEK 822
+ + I V E+ +E + + I ++++ K+E++ EK +
Sbjct: 145 ETNRDDSDNGDINYDYVH-ELSLEMKRQKI--------------QRELMKLEQENMEKRE 189
Query: 823 K--IKHEHKSE--KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK--TDD 876
+ IK E E + KL S + K + K S + K +K + T+A+ D
Sbjct: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKS--SPKSSSASKKDRKTSAVSSPLLDQ 247
Query: 877 REKSREKMDRKHDKEKPEKERHLAE--SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 934
+ S+ +K P + E + K EK + E ++ K + ++ +R+
Sbjct: 248 QRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQ 307
Query: 935 LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT------------- 981
+K++K R +S SS G+ Q P +++T
Sbjct: 308 REKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPL 367
Query: 982 -------KDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1034
L +P K+ + + R K R H+ Q + + E + K
Sbjct: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK---R 424
Query: 1035 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1094
KD+R +E+ D +D + + +++ + ++ +R+ +
Sbjct: 425 DREKDSR-EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR 483
Query: 1095 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGK 1154
+D ++++ ++ + E D + KE D S+S ++
Sbjct: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKE----DTYPEESRSYGRNHLREESS 539
Query: 1155 SSFVSDNSLNRSPRSE--NEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFML 1212
+ + + S N S RSE N++ G S V + S S + + + Y +
Sbjct: 540 RTEIRNESRNES-RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
Query: 1213 ESS 1215
SS
Sbjct: 599 RSS 601
Score = 52.4 bits (124), Expect = 5e-06
Identities = 149/827 (18%), Positives = 311/827 (37%), Gaps = 114/827 (13%)
Query: 337 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 396
E E + + D E ++ D +E+ ++ E E E+ ++E+ + + ++++
Sbjct: 716 EREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERE 775
Query: 397 RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 456
R E + ++K + D + K+E + + + G +RK K +
Sbjct: 776 RARERDKERERQRDWEDK----------DKGRDDRREKREEIREDRNPRDGHDERKSKKR 825
Query: 457 NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIS 516
+N+ + +Q + + + N+G D +EK R + P++ SL
Sbjct: 826 YRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRL---LSQVVRPQESRSL------ 876
Query: 517 TGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS 576
SP H L+E + K+E K P E S RY+ E E + SSV
Sbjct: 877 ---SPSH---LTEDRQGRWKEEDRK----PERKESSR-----RYE--EQELKEKVSSV-- 917
Query: 577 CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 636
+K + Q + LE I S E SD + K+ K KK K KE
Sbjct: 918 ----DKQREQTEI-LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972
Query: 637 REKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESL 695
+ + IE E + K + ++S+E R+ K + SDE E+
Sbjct: 973 DDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDE----------EAA 1022
Query: 696 TLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIP 755
KK + + +TKE+ V + +K+ + +F + +D+ + E
Sbjct: 1023 QQSKKKRGPRT--PPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
Query: 756 TDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE---- 811
+ + T+ G + S L + + I
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS 1140
Query: 812 ----KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKI---------KEKDKLYSHHTEKC 858
TF E + H++ +K++ + K L S+ + +
Sbjct: 1141 ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS 1200
Query: 859 HKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 917
H G +S + + ++ D + R+++ +++ K K L ++S
Sbjct: 1201 HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR---------EKTKSLEITGERKSRI 1251
Query: 918 SEYSKSEKGKNKEKDRELDKKEKSR--DKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 975
+ + E ++ DR+ + SR ES +S+ + + + + ++ +H++
Sbjct: 1252 DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRE- 1310
Query: 976 SLKEKTKDEPLKTPDGKEKDK---KDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1032
+E+ + + + ++ DK +++D DR +ER++ + E DK
Sbjct: 1311 --RERERRDTRQREWDRDADKDWPRNRDRDRLRERERER-------------ERDK---- 1351
Query: 1033 SSPASKDTRPKEKRLVNDDL-MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1091
+D + +RL++D + +R + + +IE K+ + K++ + + L + +
Sbjct: 1352 ----RRDLDRERERLISDSVERDRDRDRDRTFESSQIES-VKRCEAKLEGEHERDLESTS 1406
Query: 1092 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVS 1138
L + + K + +E +S+ +E +A E + DA S
Sbjct: 1407 RDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHS 1453
Score = 46.6 bits (109), Expect = 2e-04
Identities = 123/676 (18%), Positives = 255/676 (37%), Gaps = 90/676 (13%)
Query: 294 EEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMID 353
+E++S++PS + E+ +++ E K+ S+ L E D E ++++
Sbjct: 871 QESRSLSPSHLTEDRQGRWKEEDRKPERKE--SSRRYEEQELKEKVSSVDKQREQTEILE 928
Query: 354 DRHILRKE----QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTE--SSD 407
+ ++ + E+ +++ H K++ K K KK+ + + E S D
Sbjct: 929 SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988
Query: 408 EEALQNKKISTSCSVIPETSNS--DMQTKKEYVVSGEHKQKGK------VKRKLKNQNKN 459
+ KK S+ + S D E K++G K +L
Sbjct: 989 GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048
Query: 460 KENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGK 519
K + ++ + KE+T ++ + D +E T E + + T L +
Sbjct: 1049 KNG--ILEDSQKKEDTAFSDWSDEDVPDRTEVT--EAEHTATATTPGSTPSPLSSLLPPP 1104
Query: 520 SPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH 579
P + + +T L S +S +++ + T + F E S K H
Sbjct: 1105 PPVATATATTVPAT-LAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKC--H 1161
Query: 580 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF-----------------ENSDCTLKKMDK 622
+ + + + H+ + + K D+ S + N D+
Sbjct: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQ 1221
Query: 623 EGKTLKKHKLKHKEREKEKHKK-EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 681
G+ K L R++EK K EI GE++ + E RS DR+ + + +
Sbjct: 1222 SGR---KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRS 1278
Query: 682 ETEDLFLNMEHESLTLEKKSKLEKNIK---DDKSTKEKHVSKERNFKEERDKI------- 731
E + S + + + +L++ + D + +E+ +++R + + DK
Sbjct: 1279 SPES-DRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR 1337
Query: 732 --KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 789
+E E+ +K +DL ERE + +D VE++ D ++ +
Sbjct: 1338 DRLRERERERERDKRRDLDRERERLISDS--------------------VERDRDRDR-D 1376
Query: 790 KHIKESKEKPEKRSQIK-----EKDIEKMERKT--FEKEKKIKH----EHKSEKDKLDLS 838
+ + S+ + KR + K E+D+E R + +KE+ K + E +K + +
Sbjct: 1377 RTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERT 1436
Query: 839 ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 898
E ++ ++ KL H+ GE + + + + EK + + D+EK
Sbjct: 1437 ESLEAGDDESKLDDAHS-LGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLD 1495
Query: 899 LAESKEKHLMEKKNKQ 914
+ + LM K K+
Sbjct: 1496 VIDVDWSGLMPKHPKE 1511
Score = 42.0 bits (97), Expect = 0.006
Identities = 40/212 (18%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 838 SECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKS--REKMDRKHDKEKPE 894
++C + +K + LY + H + K ++ +++ +R RE+M K E
Sbjct: 40 TQCRNWLKTGNCLYGNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTE 99
Query: 895 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 954
++ + ++S + +S +G+++EK+ KE++ + E N+ +
Sbjct: 100 PQK------------RNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147
Query: 955 IQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1014
+ I HE L +K + L + + +K+++ I + KE +
Sbjct: 148 RDDSDNGDI--NYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK-KEVSPEVVRS 204
Query: 1015 QINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1046
+++ L+ + PK KSSP S K+++
Sbjct: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
Score = 33.9 bits (76), Expect = 1.7
Identities = 39/199 (19%), Positives = 80/199 (40%), Gaps = 27/199 (13%)
Query: 977 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1036
+K K +D + P + ++ + + R +H++K I + E+++ +
Sbjct: 89 MKNKRQDVDTE-PQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147
Query: 1037 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1096
D+ + +N D + +L +E +K + ++ + E+E + R + +K
Sbjct: 148 RDDSDNGD---INYDYVH----------ELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194
Query: 1097 IKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSS 1156
+ + E+ RSK S K PK S +S S K+ T SS
Sbjct: 195 ------------KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSS 242
Query: 1157 FVSDNSLNRSPRSENEKPG 1175
+ D N S ++++K G
Sbjct: 243 PLLDQQRN-SKTNQSKKKG 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,787,360
Number of Sequences: 37866
Number of extensions: 4229128
Number of successful extensions: 51975
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 1603
Number of HSP's that attempted gapping in prelim test: 15543
Number of HSP's gapped (non-prelim): 16555
length of query: 2039
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1921
effective length of database: 13,779,330
effective search space: 26470092930
effective search space used: 26470092930
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.