Search of human proteins with 5729796

Search of human proteins with 5729796

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729796 cytochrome P450, family 46 [Homo sapiens]
         (500 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729796 cytochrome P450, family 46 [Homo sapiens]                 1005   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   146   5e-35
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   142   5e-34
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   142   9e-34
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   141   1e-33
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   140   2e-33
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   138   1e-32
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   136   4e-32
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   135   1e-31
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   134   3e-31
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   128   1e-29
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   124   2e-28
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   124   2e-28
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   124   3e-28
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   124   3e-28
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   124   3e-28
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   119   6e-27
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   119   6e-27
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        116   4e-26
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   116   5e-26
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   113   5e-25
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   111   1e-24
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   110   4e-24
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   109   5e-24
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   106   6e-23
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   105   1e-22
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   103   4e-22
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   102   6e-22
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   102   8e-22
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    99   7e-21

>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score = 1005 bits (2599), Expect = 0.0
 Identities = 500/500 (100%), Positives = 500/500 (100%)

Query: 1   MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60
           MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
Sbjct: 1   MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

Query: 61  QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120
           QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
Sbjct: 61  QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120

Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180
           FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
Sbjct: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180

Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240
           QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
Sbjct: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240

Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300
           REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
Sbjct: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300

Query: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360
           IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360

Query: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420
           LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420

Query: 421 PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480
           PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
Sbjct: 421 PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480

Query: 481 PVLCTLRPRGWQPAPPPPPC 500
           PVLCTLRPRGWQPAPPPPPC
Sbjct: 481 PVLCTLRPRGWQPAPPPPPC 500


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  146 bits (368), Expect = 5e-35
 Identities = 126/508 (24%), Positives = 237/508 (46%), Gaps = 42/508 (8%)

Query: 6   LLLGSAVLLAFGLCCTFVHRARS----RYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQ 61
           L + + +LLA  L   +++   S    +   IPGP  P   LG++  + K     G  + 
Sbjct: 7   LAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPT-PLPFLGNILSYHK-----GFCMF 60

Query: 62  DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121
           D  ++  KKYG V       +  + +T P+ +K  L+   Y+  +      +  FG   F
Sbjct: 61  D--MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTN-----RRPFGPVGF 113

Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181
            +  +S    E W + R ++   F+   L  ++    +  + LV  L  +A+   PV+++
Sbjct: 114 MKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK 173

Query: 182 DMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML-----EGITASRNTLAKFLPGK 236
           D+    +MD++   +FG+    L   Q P  +  K +L     +    S       +P  
Sbjct: 174 DVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP-- 231

Query: 237 RKQLREVRESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG------- 285
              + EV     F R+V    R  V+R +E+ L+  ++   D L  ++ ++         
Sbjct: 232 ---ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288

Query: 286 AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE 345
           A  D  L+   + F  AG+ET+++ L+F + EL+  P++  +LQ E+D V+ +K    ++
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348

Query: 346 DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 405
            + +++YL  V+ E+LRL+P A    R+ +++  I+G+ +P    ++  +Y + R   Y+
Sbjct: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408

Query: 406 EDPLTFNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463
            +P  F P+RF          + Y PF  G R+CIG +FA M +K+ + ++LQ   F+  
Sbjct: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 468

Query: 464 PGQRFGLQEQ--ATLKPLDPVLCTLRPR 489
              +  L+      L+P  PV+  +  R
Sbjct: 469 KETQIPLKLSLGGLLQPEKPVVLKVESR 496


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  142 bits (359), Expect = 5e-34
 Identities = 137/512 (26%), Positives = 229/512 (44%), Gaps = 40/512 (7%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVF 64
           L L G++++L+         R   +   IP   R   L+GH     K D   GR      
Sbjct: 22  LSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHA-LLMKPD---GREFFQQI 77

Query: 65  LDWAKKYG--PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122
           +++ ++Y   P++++ V     V + + E+V+  L S+K    S MY+ L     E   G
Sbjct: 78  IEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFL-----EPWLG 132

Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182
            GL++     +W  +R+++   F  + L   ++  NE+A  LV+ LE K   Q   +   
Sbjct: 133 LGLLTSTG-NKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLE-KHINQEAFNCFF 190

Query: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLP---GKRKQ 239
            +T  A+DI+ + A G              +AV  M E I         +L       K+
Sbjct: 191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE 250

Query: 240 LREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------------DILTQILKAE 283
             E ++S++ L       +  R   +   E+                   D+L  +   E
Sbjct: 251 GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310

Query: 284 EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYL 342
                 E + +   TF   GH+T+A  + +++  L   PE+  ++  E+D+V G S R  
Sbjct: 311 GNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA 370

Query: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD 402
             EDL +L+YL  V+KE+LRL+P      R + E+  + G RV   T  +   Y + R  
Sbjct: 371 TVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDP 430

Query: 403 TYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460
            YF +P  F P+RF P   + R  + Y PFS G R+CIGQ+FA ME K +++ +L+   F
Sbjct: 431 RYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR--HF 488

Query: 461 RLVPGQR---FGLQEQATLKPLDPVLCTLRPR 489
            +   Q+    GL+ Q  L+P + +   L+ R
Sbjct: 489 WIESNQKREELGLEGQLILRPSNGIWIKLKRR 520


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  142 bits (357), Expect = 9e-34
 Identities = 128/500 (25%), Positives = 231/500 (46%), Gaps = 39/500 (7%)

Query: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFLLGHLPCF----WKKDEVGGRVLQDV 63
           +LLA  L   +++  R+    +   IPGP  P  LLG++  +    WK D          
Sbjct: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPT-PLPLLGNVLSYRQGLWKFDT--------- 62

Query: 64  FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123
             +  KKYG +          + +T P+ ++  L+   Y+  +   R+L  V     F +
Sbjct: 63  --ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-RSLGPVG----FMK 115

Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183
             +S    E W + R ++   F+   L  +     +  + LV  L  +A+   PV+++D+
Sbjct: 116 SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175

Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243
               +MD++   +FG+    L   Q P  ++ K  L+        L+  L      + E 
Sbjct: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEA 235

Query: 244 -------RESIRFL-RQVGRDWVQRRREALK-RGEEVPADILTQILKAEEG--AQDDEGL 292
                  +++I FL + V R    R  +  K R + +   I +Q  K  E   A  D  L
Sbjct: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295

Query: 293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 352
               + F  AG+ET+++ L+FT+ EL+  P++  +LQ E+D V+ +K    ++ + +++Y
Sbjct: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355

Query: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412
           L  V+ E+LRL+P A    R  +++  I+GV +P  + ++  TY +     Y+ +P  F 
Sbjct: 356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415

Query: 413 PDRFGPGAPK-PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ 471
           P+RF         + Y PF  G R+CIG +FA M +K+ + ++LQ   F+     +  L+
Sbjct: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475

Query: 472 --EQATLKPLDPVLCTLRPR 489
              Q  L+P  P++  +  R
Sbjct: 476 LDTQGLLQPEKPIVLKVDSR 495


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  141 bits (356), Expect = 1e-33
 Identities = 137/497 (27%), Positives = 226/497 (45%), Gaps = 62/497 (12%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARS-RYEHIPGPPRPSFLLGHLPCFWKKDE--VGGRVLQ 61
           LLL+G++ LLA  L  T+       R    P PP+ ++ LGHL      +E  +  + L 
Sbjct: 22  LLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLA 81

Query: 62  DVFLD----WAKKYGPVVRVNVFHKTSV--IVTSPESVKKFLMSTKYNKDSKMYRALQTV 115
             F D    W   +  +VR+  FH T +  ++ +P ++          KD   Y  L+  
Sbjct: 82  CTFGDMCCWWVGPWHAIVRI--FHPTYIKPVLFAPAAIVP--------KDKVFYSFLKPW 131

Query: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK---- 171
            G+     GL+     E+W + RR++  AF  + L   M+ FNE     V I+ AK    
Sbjct: 132 LGD-----GLLLSAG-EKWSRHRRMLTPAFHFNILKPYMKIFNES----VNIMHAKWQLL 181

Query: 172 -ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ-AVKLMLEGITASRNT- 228
            ++G   + M + ++   +D L K  F  ++      +KP    A  L L  +   R+  
Sbjct: 182 ASEGSARLDMFEHISLMTLDSLQKCVFSFDSHC---QEKPSEYIAAILELSALVTKRHQQ 238

Query: 229 ---LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RGEEVPADI 275
                 FL       +  R + R +       +Q RR  L           + +    D 
Sbjct: 239 ILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDF 298

Query: 276 LTQIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332
           +  +L  K E+G +  DE +     TF   GH+T+A+ L++ +  L++ PE   R + EV
Sbjct: 299 IDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEV 358

Query: 333 DEVIGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVPGNT 389
            E++  +  + ++++DL +L +L+  +KESLRL+PP     R   ++ ++ DG  +P   
Sbjct: 359 QELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGI 418

Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEV 447
             L S +        + DP  ++P RF P   K R    + PFS G R+CIGQ FA  E+
Sbjct: 419 ICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEM 478

Query: 448 KVVMAKLLQRLEFRLVP 464
           KVV+   L  L FR++P
Sbjct: 479 KVVLG--LTLLRFRVLP 493


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  140 bits (354), Expect = 2e-33
 Identities = 114/473 (24%), Positives = 216/473 (45%), Gaps = 42/473 (8%)

Query: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64
           +LLA  L   +++  R+    +   IPGP    FL   L     +W  D           
Sbjct: 13  LLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFD----------- 61

Query: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
           ++  KKY  V  +    +  + +T P+ +K  L+   Y+  +      +  FG   F + 
Sbjct: 62  MECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTN-----RRPFGPVGFMKN 116

Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184
            +S    E W + R ++   F+   L  ++    +  + LV  L  +A+   PV+++ + 
Sbjct: 117 AISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVF 176

Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA-KFLPGKRKQLREV 243
              +MD++   +FG+    L   Q P  +  K +L         L+ K  P     L  +
Sbjct: 177 GAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEAL 236

Query: 244 ------RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG-------AQDDE 290
                 R+ I FL +  +   Q +   LK  ++   D L  ++ ++         A  D 
Sbjct: 237 NITVFPRKVISFLTKSVK---QIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDL 293

Query: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350
            L+   + F  AG+ET+++ L+F + EL+  P++  ++Q E+D V+ +K    ++ + +L
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410
           +YL  V+ E+LRL+P A    R+ +++  I+G+ +P    ++  +YV+     Y+ +P  
Sbjct: 354 EYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEK 413

Query: 411 FNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
           F P+RF          + Y PF  G R+CIG +FA + +K+ + ++LQ   F+
Sbjct: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  138 bits (348), Expect = 1e-32
 Identities = 132/490 (26%), Positives = 226/490 (46%), Gaps = 54/490 (11%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKD---EVGGRVLQ 61
           LL     +LL F   C   +    R    P PPR ++LLGHL  +   +   +   +VL 
Sbjct: 31  LLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLD 90

Query: 62  D---VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRALQTVF 116
           +   V L W    GPV+ +       +++  P+ +K  L ++     KD   Y  L+   
Sbjct: 91  NMHHVLLVWM---GPVLPL-------LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWL 140

Query: 117 GERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT 176
           G+ L    L+S+   ++W + RR++  AF    L   M+ FN+ A+ +       A+G  
Sbjct: 141 GDGL----LLSKG--DKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSA 194

Query: 177 -PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE--GITASR----NTL 229
             + M + ++   +D L K  F   ++     Q+ +S  +  ++E   ++  R    +  
Sbjct: 195 VSLDMFEHISLMTLDSLQKCVFSYNSN----CQEKMSDYISAIIELSALSVRRQYRLHHY 250

Query: 230 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREAL-----------KRGEEVPADILTQ 278
             F+  +    R  R++   +     + +Q RR AL           K+G+ +    +  
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL 310

Query: 279 ILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 337
           + + E+G +  DE +     TF   GH+T+++ +++ +  L++ PE   + + E+ EV+ 
Sbjct: 311 LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMK 370

Query: 338 SKRY--LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET-LIDGVRVPGNTPLLFS 394
            +    L+++DL +L + +  +KESLR YPP     R   E+  L DG  +P     L S
Sbjct: 371 GRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVS 430

Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMA 452
            Y      T + D   +NP RF P  P+ R    Y PFS G R+CIGQ FA  E++VV+A
Sbjct: 431 IYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVA 490

Query: 453 KLLQRLEFRL 462
             L  L FRL
Sbjct: 491 --LTLLRFRL 498


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  136 bits (343), Expect = 4e-32
 Identities = 138/507 (27%), Positives = 233/507 (45%), Gaps = 68/507 (13%)

Query: 2   SPGLLLL--GSAVLLAFGLCCT--FVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGG 57
           SP LLLL  G++ LLA  L  T  F H  R R    P P + ++ LGHL      +E G 
Sbjct: 17  SPWLLLLVVGASWLLARILAWTYAFYHNGR-RLRCFPQPRKQNWFLGHLGLVTPTEE-GL 74

Query: 58  RVLQDV-------FLDWAKKYGPVVRVNVFHKTSV--IVTSPESVKKFLMSTKYNKDSKM 108
           RVL  +       F+ W     P++  N+ H   V  ++ + +++         +KD   
Sbjct: 75  RVLTQLVATYPQGFVRWLGPITPII--NLCHPDIVRSVINTSDAIT--------DKDIVF 124

Query: 109 YRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEIL 168
           Y+ L+   G+     GL+     ++W   RR++  AF  + L   ++ F++ A     I+
Sbjct: 125 YKTLKPWLGD-----GLLLSVG-DKWRHHRRLLTPAFHFNILKPYIKIFSKSAN----IM 174

Query: 169 EAK-----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM-LEGI 222
            AK      +G T + + + ++   +D L K  F  +++     +KP      +M L  +
Sbjct: 175 HAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNC---QEKPSEYITAIMELSAL 231

Query: 223 TASRNT----LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RG 268
              RN        FL       R    + R +       +Q RR  L           + 
Sbjct: 232 VVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKA 291

Query: 269 EEVPADILTQILKAEE--GAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 325
           +    D +  +L +E+  G +  DE +     TF   GH+T+A+ L++ +  L+R PE  
Sbjct: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351

Query: 326 ARLQAEVDEVIGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGV 383
            R + EV E++  +  + ++++DL +L +L+  LKESLRL+PP     R   ++ ++   
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411

Query: 384 RV-PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQ 440
           RV P       + + +    + + DP  ++P RF P   + R    + PFS G R+CIGQ
Sbjct: 412 RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQ 471

Query: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQR 467
           +FA  E+KVV+A  L  L FR++P  R
Sbjct: 472 KFAMAEMKVVLA--LTLLRFRILPDHR 496


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  135 bits (339), Expect = 1e-31
 Identities = 129/494 (26%), Positives = 231/494 (46%), Gaps = 46/494 (9%)

Query: 1   MSPGLLLL--GSAVLLAFGLCCTFV-HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGG 57
           MSP LLLL    + LLA  L  T+  +    R +  P PP+ ++  GHL      +E G 
Sbjct: 16  MSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEE-GL 74

Query: 58  RVLQDVFLDWAKKY----GPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRA 111
           +    +   +++ +    GP++         +++  P++++    ++     KD+   R 
Sbjct: 75  KDSTQMSATYSQGFTVWLGPIIPF-------IVLCHPDTIRSITNASAAIAPKDNLFIRF 127

Query: 112 LQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK 171
           L+   GE +   G       ++W + RR++  AF  + L S +  FN+ A  +++  +  
Sbjct: 128 LKPWLGEGILLSG------GDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHL 181

Query: 172 A-DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 230
           A +G + + M + ++   +D L K  F  ++       + ++  ++L       S++ L 
Sbjct: 182 ASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241

Query: 231 K--FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RGEEVPADILTQ 278
              FL       R    + R +       ++ RR  L           + +    D +  
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301

Query: 279 IL--KAEEG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335
           +L  K E+G A  DE +     TF   GH+T+A+ L++ +  L+R PE   R + EV E+
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361

Query: 336 IGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVPGNTPLL 392
           +  +  + ++++DL +L +L+  +KESLRL+PPA    R   ++ ++ DG  +P     L
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCL 421

Query: 393 FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVV 450
                +    T + DP  ++P RF P   K R    + PFS G R+CIGQ FA  E+KVV
Sbjct: 422 IDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVV 481

Query: 451 MAKLLQRLEFRLVP 464
           +A +L  L FR +P
Sbjct: 482 LALML--LHFRFLP 493


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  134 bits (336), Expect = 3e-31
 Identities = 134/495 (27%), Positives = 225/495 (45%), Gaps = 58/495 (11%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSR-YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDV 63
           LLL+G++ LLA  L  T+      R     P PPR ++  GH       +E G RVL  +
Sbjct: 22  LLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEE-GMRVLTQL 80

Query: 64  FLDWAKKY----GPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRALQTVFG 117
              + + +    GP+  +       + +  P+ ++  + ++     KD   Y  L     
Sbjct: 81  VATYPQGFKVWMGPISPL-------LSLCHPDIIRSVINASAAIAPKDKFFYSFL----- 128

Query: 118 ERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK-----A 172
           E   G GL+     ++W + RR++  AF  + L   M+ FNE     V I+ AK     +
Sbjct: 129 EPWLGDGLLLSAG-DKWSRHRRMLTPAFHFNILKPYMKIFNES----VNIMHAKWQLLAS 183

Query: 173 DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ-AVKLMLEGITASRN---- 227
           +G   + M + ++   +D L K  F  ++      +KP    A  L L  + + R+    
Sbjct: 184 EGSACLDMFEHISLMTLDSLQKCVFSFDSHC---QEKPSEYIAAILELSALVSKRHHEIL 240

Query: 228 TLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RGEEVPADILT 277
               FL       +  R + R +       +Q RR  L           + +    D + 
Sbjct: 241 LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300

Query: 278 QIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334
            +L  K E+G +  DE +     TF   GH+T+A+ L++ +  L++ PE   R + EV E
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360

Query: 335 VIGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVPGNTPL 391
           ++  +  + ++++DL  L +L+  +KESLRL+PP     R + ++ ++ DG  +P     
Sbjct: 361 LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC 420

Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKV 449
           L S +        + DP  ++P RF P   K R    + PFS G R+CIGQ FA  E+KV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480

Query: 450 VMAKLLQRLEFRLVP 464
           V+A  L  L FR++P
Sbjct: 481 VLA--LTLLRFRVLP 493


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  128 bits (322), Expect = 1e-29
 Identities = 107/470 (22%), Positives = 207/470 (44%), Gaps = 36/470 (7%)

Query: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64
           VL+A  L   +++   S    +   IPGP    FL   L +L   W  D           
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDR---------- 62

Query: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
            +  +KYG +  +    +  +++  P+ +K  L+   Y+  +      Q   G   F + 
Sbjct: 63  -ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN-----QMPLGPMGFLKS 116

Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184
            +S    E W + R ++  AF+      ++   ++  + LV  L  +A+    ++++D  
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244
               MD++    FG+    L   Q P  + +K +L+        L   L      + E  
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEAL 236

Query: 245 ESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQDDEGLL 293
               F + V    ++ ++R +E+ LK  ++   D   Q++ ++         A  D  L+
Sbjct: 237 NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELV 296

Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353
              +    A ++T++  L F + EL+  P++  +LQ E+D V+ +K  + ++ L +++YL
Sbjct: 297 AQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356

Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413
             V+ E+LRL+P      R+ +++  I+GV +P    ++   Y +     Y+ +P  F P
Sbjct: 357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416

Query: 414 DRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
           +RF          + Y PF  G R+CIG +FA   +K+ + + LQ   F+
Sbjct: 417 ERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  124 bits (312), Expect = 2e-28
 Identities = 105/380 (27%), Positives = 170/380 (44%), Gaps = 28/380 (7%)

Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192
           +W + R+++   F    L   +  F E    +++  E KA       +   + + A++ L
Sbjct: 133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL 192

Query: 193 AKAAFGM--------ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244
            K  FG         ++S  L A   L+  ++  L       + +    P  R+ LR  +
Sbjct: 193 MKCTFGRGDTGLGHRDSSYYL-AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQ 251

Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ----ILKAEEGAQD-------DEGLL 293
                +     D V R R+A  + E+V   I  +     L    GA+D       D  L 
Sbjct: 252 -----VAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLR 306

Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353
               TF   GH+T+ + +++ +  ++  PE   R + EV E++G + +  ++DLG++ YL
Sbjct: 307 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYL 366

Query: 354 SQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412
           +  +KES RLYPP    +R L +  T +DG  +P  + +    Y + R    + DP  F+
Sbjct: 367 TMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD 426

Query: 413 PDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470
             RF       R  F + PFS G R+CIGQQFA  E+KVV A  L R EF L P +    
Sbjct: 427 SLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIK 486

Query: 471 QEQATLKPLDPVLCTLRPRG 490
             Q  L+  +     L+P G
Sbjct: 487 MPQLVLRSKNGFHLHLKPLG 506


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  124 bits (311), Expect = 2e-28
 Identities = 105/381 (27%), Positives = 170/381 (44%), Gaps = 29/381 (7%)

Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192
           +W + R+++   F    L   +  F E    +++  E KA       +   + + A++ L
Sbjct: 133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL 192

Query: 193 AKAAFGM---------ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243
            K  FG          ++S  L A   L+  ++  L       + +    P  R+ LR  
Sbjct: 193 MKCTFGRGDTGLGHSRDSSYYL-AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 251

Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ----ILKAEEGAQD-------DEGL 292
           +     +     D V R R+A  + E+V   I  +     L    GA+D       D  L
Sbjct: 252 Q-----VAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADL 306

Query: 293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 352
                TF   GH+T+ + +++ +  ++  PE   R + EV E++G + +  ++DLG++ Y
Sbjct: 307 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTY 366

Query: 353 LSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411
           L+  +KES RLYPP    +R L +  T +DG  +P  + +    Y + R    + DP  F
Sbjct: 367 LTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426

Query: 412 NPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 469
           +  RF       R  F + PFS G R+CIGQQFA  E+KVV A  L R EF L P +   
Sbjct: 427 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPI 486

Query: 470 LQEQATLKPLDPVLCTLRPRG 490
              Q  L+  +     L+P G
Sbjct: 487 KMPQLVLRSKNGFHLHLKPLG 507


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  124 bits (310), Expect = 3e-28
 Identities = 107/471 (22%), Positives = 207/471 (43%), Gaps = 37/471 (7%)

Query: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64
           VL+A  L   +++   S    +   IPGP    FL   L +L   W  D           
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDR---------- 62

Query: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
            +  +KYG +  +    +  +++  P+ +K  L+   Y+  +      Q   G   F + 
Sbjct: 63  -ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN-----QMPLGPMGFLKS 116

Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184
            +S    E W + R ++  AF+      ++   ++  + LV  L  +A+    ++++D  
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244
               MD++    FG+    L   Q P  + +K +L+        L   L      + E  
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEAL 236

Query: 245 ESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQDDEGLL 293
               F + V    ++ ++R +E+ LK  ++   D   Q++ ++         A  D  L+
Sbjct: 237 NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELV 296

Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353
              +    A ++T++  L F + EL+  P++  +LQ E+D V+ +K  + ++ L +++YL
Sbjct: 297 AQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356

Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413
             V+ E+LRL+P      R+ +++  I+GV +P    ++   Y +     Y+ +P  F P
Sbjct: 357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416

Query: 414 D-RFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
           + RF          + Y PF  G R+CIG +FA   +K+ + + LQ   F+
Sbjct: 417 ESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 467


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  124 bits (310), Expect = 3e-28
 Identities = 126/500 (25%), Positives = 226/500 (45%), Gaps = 68/500 (13%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSR-YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDV 63
           LLL+G + LLA  L  T+      R  +  P PP+ ++  GH       +E G + L  +
Sbjct: 22  LLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEE-GMKTLTQL 80

Query: 64  FLDWAKKY----GPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRALQTVFG 117
              + + +    GP   +       +I+  P+ ++    ++     KD   Y  L+   G
Sbjct: 81  VTTYPQGFKLWLGPTFPL-------LILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLG 133

Query: 118 ERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKA-DGQT 176
           + L   G       ++W + RR++  AF  + L   M+ FN+    + +  +  A +G  
Sbjct: 134 DGLLLSG------GDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSA 187

Query: 177 PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGK 236
            + M + ++   +D L K  F  E++     Q+  S+ +  +LE        L+ F+  +
Sbjct: 188 RLDMFEHISLMTLDSLQKCVFSFESN----CQEKPSEYIAAILE--------LSAFVEKR 235

Query: 237 RKQLREVRESIRFLRQVGRDW--------------VQRRREAL----------KRGEEVP 272
            +Q+    + + +L   G+ +              +Q RR  L           + +   
Sbjct: 236 NQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 273 ADILTQIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ 329
            D +  +L  K E+G +  DE +     TF   GH+T+A+ L++ +  L++ PE   + +
Sbjct: 296 LDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCR 355

Query: 330 AEVDEVIGSKRYLDFE--DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVP 386
            EV E++  +  ++ E  DL +L +L+  +KESLRL+PP     R   ++ ++ DG  +P
Sbjct: 356 QEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIP 415

Query: 387 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQ 444
                L +   +    T + DP  ++P RF     K R    + PFS G R+CIGQ FA 
Sbjct: 416 KGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAM 475

Query: 445 MEVKVVMAKLLQRLEFRLVP 464
            E+KVV+A  L  L FR++P
Sbjct: 476 AEMKVVLA--LTLLHFRILP 493


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  124 bits (310), Expect = 3e-28
 Identities = 126/500 (25%), Positives = 226/500 (45%), Gaps = 68/500 (13%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSR-YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDV 63
           LLL+G + LLA  L  T+      R  +  P PP+ ++  GH       +E G + L  +
Sbjct: 22  LLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEE-GMKTLTQL 80

Query: 64  FLDWAKKY----GPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRALQTVFG 117
              + + +    GP   +       +I+  P+ ++    ++     KD   Y  L+   G
Sbjct: 81  VTTYPQGFKLWLGPTFPL-------LILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLG 133

Query: 118 ERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKA-DGQT 176
           + L   G       ++W + RR++  AF  + L   M+ FN+    + +  +  A +G  
Sbjct: 134 DGLLLSG------GDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSA 187

Query: 177 PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGK 236
            + M + ++   +D L K  F  E++     Q+  S+ +  +LE        L+ F+  +
Sbjct: 188 RLDMFEHISLMTLDSLQKCVFSFESN----CQEKPSEYIAAILE--------LSAFVEKR 235

Query: 237 RKQLREVRESIRFLRQVGRDW--------------VQRRREAL----------KRGEEVP 272
            +Q+    + + +L   G+ +              +Q RR  L           + +   
Sbjct: 236 NQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 273 ADILTQIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ 329
            D +  +L  K E+G +  DE +     TF   GH+T+A+ L++ +  L++ PE   + +
Sbjct: 296 LDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCR 355

Query: 330 AEVDEVIGSKRYLDFE--DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVP 386
            EV E++  +  ++ E  DL +L +L+  +KESLRL+PP     R   ++ ++ DG  +P
Sbjct: 356 QEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIP 415

Query: 387 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQ 444
                L +   +    T + DP  ++P RF     K R    + PFS G R+CIGQ FA 
Sbjct: 416 KGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAM 475

Query: 445 MEVKVVMAKLLQRLEFRLVP 464
            E+KVV+A  L  L FR++P
Sbjct: 476 AEMKVVLA--LTLLHFRILP 493


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  119 bits (298), Expect = 6e-27
 Identities = 116/492 (23%), Positives = 200/492 (40%), Gaps = 82/492 (16%)

Query: 37  PRPSFLLGHLPCF----WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92
           P+PS  +G+L  F    W+             ++  K YGP+    +  +  ++++ P+ 
Sbjct: 48  PKPSPFIGNLTFFRQGFWESQ-----------MELRKLYGPLCGYYLGRRMFIVISEPDM 96

Query: 93  VKKFLMSTKYNKDSKMYRALQ--TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150
           +K+ L+    N  ++M   L+  +V    LF +        +RW + R  +  AFS   L
Sbjct: 97  IKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-------KRWEEVRGALMSAFSPEKL 149

Query: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210
             ++   ++  + L+  L+  A+      +Q        D++A  AFG         + P
Sbjct: 150 NEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 209

Query: 211 ------------LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWV 258
                       + + + ++L    +    LA+ LP K +      E   F  ++ R+ +
Sbjct: 210 FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRD-----ELNGFFNKLIRNVI 264

Query: 259 QRRREALKRGEEVPADILTQILKAEE-----GAQDDEGLLDNFVT--------------- 298
             R +  +  EE   D L  +L A       G QD + + D F +               
Sbjct: 265 ALRDQ--QAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSP 322

Query: 299 ----------------FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342
                           F IAG+E   N L+F    L+  P+   +L  EVD         
Sbjct: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382

Query: 343 DFEDLGR-LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401
           +F  L   L YL  V+ E+LR+YPPA+   R   ++  + G R+P    L  +   +   
Sbjct: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442

Query: 402 DTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459
             ++  P TFNP+RF   A +    FTY PF  G RSC+G +   +EVK+ +  +L +  
Sbjct: 443 PEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502

Query: 460 FRLVPGQRFGLQ 471
           F+  P  +  LQ
Sbjct: 503 FQACPETQVPLQ 514


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  119 bits (298), Expect = 6e-27
 Identities = 116/492 (23%), Positives = 200/492 (40%), Gaps = 82/492 (16%)

Query: 37  PRPSFLLGHLPCF----WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92
           P+PS  +G+L  F    W+             ++  K YGP+    +  +  ++++ P+ 
Sbjct: 48  PKPSPFIGNLTFFRQGFWESQ-----------MELRKLYGPLCGYYLGRRMFIVISEPDM 96

Query: 93  VKKFLMSTKYNKDSKMYRALQ--TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150
           +K+ L+    N  ++M   L+  +V    LF +        +RW + R  +  AFS   L
Sbjct: 97  IKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-------KRWEEVRGALMSAFSPEKL 149

Query: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210
             ++   ++  + L+  L+  A+      +Q        D++A  AFG         + P
Sbjct: 150 NEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 209

Query: 211 ------------LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWV 258
                       + + + ++L    +    LA+ LP K +      E   F  ++ R+ +
Sbjct: 210 FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRD-----ELNGFFNKLIRNVI 264

Query: 259 QRRREALKRGEEVPADILTQILKAEE-----GAQDDEGLLDNFVT--------------- 298
             R +  +  EE   D L  +L A       G QD + + D F +               
Sbjct: 265 ALRDQ--QAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSP 322

Query: 299 ----------------FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342
                           F IAG+E   N L+F    L+  P+   +L  EVD         
Sbjct: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382

Query: 343 DFEDLGR-LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401
           +F  L   L YL  V+ E+LR+YPPA+   R   ++  + G R+P    L  +   +   
Sbjct: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442

Query: 402 DTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459
             ++  P TFNP+RF   A +    FTY PF  G RSC+G +   +EVK+ +  +L +  
Sbjct: 443 PEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502

Query: 460 FRLVPGQRFGLQ 471
           F+  P  +  LQ
Sbjct: 503 FQACPETQVPLQ 514


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  116 bits (291), Expect = 4e-26
 Identities = 108/430 (25%), Positives = 188/430 (43%), Gaps = 44/430 (10%)

Query: 69  KKYGPVVRVNVFHK----------------TSVIVTSPESVKKFLMSTKYNKDSKMYRAL 112
           K++ PV    V+HK                T           K L+  +  K +  ++ L
Sbjct: 58  KEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKIL 117

Query: 113 QTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKA 172
                E   G+GLV+  +  +W K R+++   F+ S L   +   +E    ++   E   
Sbjct: 118 -----ESWVGRGLVT-LDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHI 171

Query: 173 DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKF 232
              + + +   ++   +D + K AF  + S+ L +   L   +K +      S   +  F
Sbjct: 172 AQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDST--LDSYLKAVFNLSKISNQRMNNF 229

Query: 233 LPGKRKQLREVRESIRF------LRQVGRDWVQRRREALK------RGEEVPADILTQIL 280
           L       +   +   F      L Q     +Q R+E+LK        ++   D L  +L
Sbjct: 230 LHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILL 289

Query: 281 KAE-EGAQD--DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 337
            A+ E  +D  +  L     TF  AGH+T+++ +++ +  L++ PE   R + E+ E++G
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349

Query: 338 SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTY 396
               + +E L ++ Y +  +KE LRLY P     RLL++  T  DG  +P    +  + +
Sbjct: 350 DGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIW 409

Query: 397 VMGRMDTYFEDPLTFNPDRFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454
            +     ++EDP  FNP RF     +    + + PFS G R+CIGQ FA +E KV +A  
Sbjct: 410 ALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVA-- 467

Query: 455 LQRLEFRLVP 464
           L  L F+L P
Sbjct: 468 LTLLRFKLAP 477


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  116 bits (290), Expect = 5e-26
 Identities = 96/371 (25%), Positives = 169/371 (45%), Gaps = 29/371 (7%)

Query: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175
           F   L G+GL +  +  +W + RR++   F  + L + +E      + +++  E     Q
Sbjct: 116 FSPPLLGKGLAA-LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174

Query: 176 -TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP--------LSQAVKLMLEGITASR 226
            T V + + +   ++DI+ K AF  ET+    +           LS+ +   L  +    
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234

Query: 227 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG---EEVPADILTQILKAE 283
           + + K  P    Q    ++  R L Q     +Q R+++L+ G   +  P       L   
Sbjct: 235 DIIFKLSP----QGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV 290

Query: 284 EGAQDDEG-------LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336
             A+D+ G       +     TF +AGH+T A  +++ +  L+  PE   R + EV  ++
Sbjct: 291 LSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGIL 350

Query: 337 GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFST 395
           G    + ++ LG + Y +  +KE+ RL P      R L +  T  DG  +P    ++ S 
Sbjct: 351 GDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSI 410

Query: 396 YVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAK 453
           + +      +++P  F+P RF       R  + Y PFS G R+CIGQ+FA +E+KV +A 
Sbjct: 411 WGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIAL 470

Query: 454 LLQRLEFRLVP 464
           +L  L FR+ P
Sbjct: 471 IL--LHFRVTP 479


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  113 bits (282), Expect = 5e-25
 Identities = 124/504 (24%), Positives = 216/504 (42%), Gaps = 42/504 (8%)

Query: 3   PGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQD 62
           P  LLLG+   +AF L   F+ R R +  + PGP R  FL      F+  D     +   
Sbjct: 18  PRTLLLGT---VAFLLAADFLKRRRPK-NYPPGPWRLPFLGN----FFLVDFEQSHLEVQ 69

Query: 63  VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122
           +F+   KKYG +  + +   ++V++T    +K+ L+    N  ++    ++    E +F 
Sbjct: 70  LFV---KKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMR----EHIFK 122

Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSM 180
           +  +   + + W +QRR    A     L   SL E   E+A+ L E +  K +   P   
Sbjct: 123 KNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAI--KEENGQPFDP 180

Query: 181 QDMLTYTAMDILAKAAFG----METSMLLGAQKPLSQAVKLMLEGITASRNT---LAKFL 233
              +     +I+    FG     + S      K L +   L         N    + KFL
Sbjct: 181 HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 240

Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-------GA 286
           PG  + L    + ++         + + R+     E    D +   LK           +
Sbjct: 241 PGPHQTLFSNWKKLKLFVS---HMIDKHRKDWNPAET--RDFIDAYLKEMSKHTGNPTSS 295

Query: 287 QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346
             +E L+ + +  F AG ET++  L + ++ ++  PEI  ++QAE+D VIG  +      
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA 355

Query: 347 LGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 405
              + Y + V+ E  R+         R +  +T + G  +P  T +L +   + R  T +
Sbjct: 356 RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415

Query: 406 EDPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464
             P TFNPD F   G  K R  + PFS+G R+C+G+Q A+ E+ +    L+Q+  FR   
Sbjct: 416 ATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPN 475

Query: 465 GQRFGLQEQ--ATLKPLDPVLCTL 486
            ++  L+ +   T+ P+   LC +
Sbjct: 476 NEKLSLKFRMGITISPVSHRLCAV 499


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  111 bits (278), Expect = 1e-24
 Identities = 95/363 (26%), Positives = 163/363 (44%), Gaps = 28/363 (7%)

Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181
           G GL+   N + W + RR++  AF    L   +    +    +++  E      +P+ + 
Sbjct: 128 GYGLLL-LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVF 186

Query: 182 DMLTYTAMDILAKAAFGMETSM--------LLGAQKPLSQAVKLMLEGITASRNTLAKFL 233
             ++   +D + K AF  + S+         + A   L+  V   +       +T+    
Sbjct: 187 QHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLT 246

Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------DILTQILKAE 283
              R   R  + + +   QV    +Q R+  L++  E+            DIL  + K E
Sbjct: 247 SAGRWTHRACQLAHQHTDQV----IQLRKAQLQKEGELEKIKRKRHLDFLDILL-LAKME 301

Query: 284 EGA-QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342
            G+   D+ L     TF   GH+T+A+ +++ +  L+  P+   R + E+  ++G    +
Sbjct: 302 NGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI 361

Query: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRM 401
            +  L ++ Y +  +KE+LRLYPP  G  R L    T  DG  +P    +L S Y +   
Sbjct: 362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHN 421

Query: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
              + +P  F+P RF PG+ +    + PFS G R+CIG+QFA  E+KV  A  L  L F 
Sbjct: 422 PKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATA--LTLLRFE 479

Query: 462 LVP 464
           L+P
Sbjct: 480 LLP 482


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  110 bits (274), Expect = 4e-24
 Identities = 120/463 (25%), Positives = 191/463 (41%), Gaps = 31/463 (6%)

Query: 24  HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT 83
           H AR     IPGP  PSFL   L C     + G   L ++ +  A  +GPV   +     
Sbjct: 31  HSARRSLADIPGPSTPSFL-AELFC-----KGGLSRLHELQVQGAAHFGPVWLASFGTVR 84

Query: 84  SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-D 142
           +V V +P  V++ L       +   +         R    GL++    E W + R ++  
Sbjct: 85  TVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLT-AEGEEWQRLRSLLAP 143

Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT--PVSMQDM---LTYTAMDILAKAAF 197
           L     +      T N     LV  L  +    T  P  ++D+        ++ +A    
Sbjct: 144 LLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLL 203

Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL------REVRESIRFLR 251
           G     L  AQ P      +   G       L   +P   + L      R  R+  +   
Sbjct: 204 GSRLGCL-EAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFA 262

Query: 252 QVGRDWVQRRREA-LKRGEEVPADI-----LTQILKAEEGAQDDEGLLDNFVTFFIAGHE 305
              R   +R  EA ++ G +   D+     LT  L  EE     + +L N     +AG +
Sbjct: 263 FAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE--LPAQSILGNVTELLLAGVD 320

Query: 306 TSANHLAFTVMELSRQPEIVARLQAEVDEVI--GSKRYLDFEDLGRLQYLSQVLKESLRL 363
           T +N L++ + ELSR PE+   L +E+   +  GS  Y     L +L  L  V+KE LRL
Sbjct: 321 TVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRL 380

Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423
           YP   G  R+ +++  +    +P NT +    Y   R    F +P +F P R+    P P
Sbjct: 381 YPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP 440

Query: 424 R-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 465
             F   PF  G RSC+G++ A++E+++ +A++L   E +  PG
Sbjct: 441 HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPG 483


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  109 bits (273), Expect = 5e-24
 Identities = 93/363 (25%), Positives = 164/363 (45%), Gaps = 28/363 (7%)

Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181
           G GL+   N + W + RR++  AF    L   +    +    +++  E      +P+ + 
Sbjct: 128 GYGLLL-LNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVF 186

Query: 182 DMLTYTAMDILAKAAFGMETSM--------LLGAQKPLSQAVKLMLEGITASRNTLAKFL 233
             ++   +D + K+AF  + S+         + A   L+  V   +       +T+    
Sbjct: 187 QHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT 246

Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------DILTQILKAE 283
              R   R  + + +   QV    +Q R+  L++  E+            DIL  + K E
Sbjct: 247 SAGRWTHRACQLAHQHTDQV----IQLRKAQLQKEGELEKIKRKRHLDFLDILL-LAKME 301

Query: 284 EGA-QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342
            G+   D+ L     TF   GH+T+A+ +++ +  L+  P+   R + E+  ++G    +
Sbjct: 302 NGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASI 361

Query: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRM 401
            +  L ++ Y +  +KE+LRLYPP  G  R L    T  DG  +P    +L S Y +   
Sbjct: 362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHN 421

Query: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
              + +   F+P RF PG+ +    + PFS G R+CIG+QFA  ++KV  A+ L  L F 
Sbjct: 422 PKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKV--ARALTLLRFE 479

Query: 462 LVP 464
           L+P
Sbjct: 480 LLP 482


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  106 bits (264), Expect = 6e-23
 Identities = 59/170 (34%), Positives = 98/170 (57%), Gaps = 6/170 (3%)

Query: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360
           +AG +T++N L + +  LS+ PEI   L  EV  V+ + +    +D   +  L  VLKE+
Sbjct: 334 MAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKET 393

Query: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF---- 416
           LRLYP      R++E+E  +DG   P NT  +F  YV+ R  T F +P +F P R+    
Sbjct: 394 LRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNS 453

Query: 417 GPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464
            P  P+ +  F   PF  G R+C+G++ A++E+++++A+L+Q+ +  L P
Sbjct: 454 QPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAP 503


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  105 bits (261), Expect = 1e-22
 Identities = 116/465 (24%), Positives = 198/465 (42%), Gaps = 42/465 (9%)

Query: 14  LAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGP 73
           L  GL    V R  + ++ +P  PRP  LLG+L       ++  R L   FL + +KYG 
Sbjct: 11  LLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLL------QMDRRGLLKSFLRFREKYGD 64

Query: 74  VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER 133
           V  V++  +  V++   E++++ L+        +   A+   F     G G++   N  R
Sbjct: 65  VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFR---GYGVIF-ANGNR 120

Query: 134 WHKQRR--VIDLAFSRSSLVSLMETFNEKAEQLVEIL-EAKADGQTPVSMQDMLTYTAMD 190
           W   RR  V  +        S+ E   E+A+ L+E L ++K     P  +   +T    +
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSIT---AN 177

Query: 191 ILAKAAFG-------METSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243
           I+    FG        E   +L         +  +   +    +   K+ PG  +Q+ + 
Sbjct: 178 IICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN 237

Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL----KAEEGAQDD---EGLLDNF 296
            + I     +G   V++ RE L      P D++   L    K +  A  +   + L  N 
Sbjct: 238 LQEIN--AYIGHS-VEKHRETLD--PSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292

Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356
           ++ F AG ET++  L +  + + + P +  R+  E+++VIG  R  +  D  ++ Y   V
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 357 LKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413
           + E  R   L P   G   ++ + T   G  +P +T +            YFE P  FNP
Sbjct: 353 IYEIQRFSDLLP--MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410

Query: 414 DRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456
           D F    GA K    + PFSLG R C+G+  A+ E+ +    +LQ
Sbjct: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  103 bits (257), Expect = 4e-22
 Identities = 105/464 (22%), Positives = 199/464 (42%), Gaps = 36/464 (7%)

Query: 33  IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSP-- 90
           +PGP     L   L   WK    G +   D  +++ KKYG + R+ +    SV + SP  
Sbjct: 58  LPGPTSWPLLGSLLQILWKG---GLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114

Query: 91  -ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS 149
            E++ +   +     + K ++A +    E   G GL+     E W + R        +  
Sbjct: 115 LEALYRTESAYPQRLEIKPWKAYRDYRKE---GYGLLI-LEGEDWQRVRSAFQKKLMKPG 170

Query: 150 LVSLMET--------FNEKAEQL------VEILEAKADGQTPVSMQDMLTYTAMDILAKA 195
            V  ++         F  + ++L      VE L ++ +  +  S+  +L      +L K 
Sbjct: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230

Query: 196 AFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGR 255
           A     + ++  +  +S   ++M+  +   ++   K           + +S++       
Sbjct: 231 AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKAC----- 285

Query: 256 DWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTV 315
             +  R E  K  ++  AD L  I      ++ +  L        +A  ET+AN L + +
Sbjct: 286 --IDNRLE--KYSQQPSADFLCDIYHQNRLSKKE--LYAAVTELQLAAVETTANSLMWIL 339

Query: 316 MELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLE 375
             LSR P++  +L  E+  V+   +    EDL  + YL   LKES+RL P    T R L+
Sbjct: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLD 399

Query: 376 EETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-FTYFPFSLGH 434
           + T++    +P  T L+ +T V+G  +  FED   F P+R+     K   F + PF +G 
Sbjct: 400 KATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGK 459

Query: 435 RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKP 478
           R CIG++ A++++ + +  ++++ + +    +   +    TL P
Sbjct: 460 RMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVP 503


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  102 bits (255), Expect = 6e-22
 Identities = 115/488 (23%), Positives = 210/488 (43%), Gaps = 45/488 (9%)

Query: 1   MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60
           ++ G+LL+   V L   +  +   + +S+ +  PGP    F+  +L       ++    +
Sbjct: 2   LASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYL-------QLNTEQM 54

Query: 61  QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120
            +  +  +++YGPV  +++  +  V++   ++V++ L+      +    R  Q  F    
Sbjct: 55  YNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD---QAEEFSGRGEQATFDWVF 111

Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVS---LMETFNEKAEQLVEILEAKADGQTP 177
            G G+V   N ER  KQ R   +A  R   V    + E   E+A  L++ L  +  G   
Sbjct: 112 KGYGVVFS-NGER-AKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDAL--RGTGGAN 167

Query: 178 VSMQDMLTYTAMDILAKAAFG-------METSMLLGAQKPLSQAVKLMLEGITASRNTLA 230
           +     L+ T  ++++   FG        E   LL     + Q        +    +++ 
Sbjct: 168 IDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVM 227

Query: 231 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKR--GEEVPADILTQIL---KAEEG 285
           K LPG ++Q  ++ + +        D++ ++ E  +R      P D +   L   + EE 
Sbjct: 228 KHLPGPQQQAFQLLQGLE-------DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEK 280

Query: 286 AQDDEGLLDNFV----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 341
             + E  L N V      FI G ET +  L +  + L + PE+ A++  E+D VIG  R 
Sbjct: 281 NPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQ 340

Query: 342 LDFEDLGRLQYLSQVLKESLRLYPP-AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 400
             FED  ++ Y+  V+ E  R          R ++++T      +P  T +      + R
Sbjct: 341 PKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLR 400

Query: 401 MDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458
             ++F +P  FNP  F    G  K    + PFS+G R+C G+  A+ME+ +    ++Q  
Sbjct: 401 DPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ-- 458

Query: 459 EFRLVPGQ 466
            FRL   Q
Sbjct: 459 NFRLKSSQ 466


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  102 bits (254), Expect = 8e-22
 Identities = 92/422 (21%), Positives = 184/422 (43%), Gaps = 34/422 (8%)

Query: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64
           VL+A  L   +++   S    +   IPGP    FL   L +L   W  D           
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDR---------- 62

Query: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
            +  +KYG +  +    +  +++  P+ +K  L+   Y+  +      Q   G   F + 
Sbjct: 63  -ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN-----QMPLGPMGFLKS 116

Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184
            +S    E W + R ++  AF+      ++   ++  + LV  L  +A+    ++++D  
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244
               MD++    FG+    L   Q P  + +K +L+        L   L      + E  
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEAL 236

Query: 245 ESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQDDEGLL 293
               F + V    ++ ++R +E+ LK  ++   D   Q++ ++         A  D  L+
Sbjct: 237 NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELV 296

Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353
              +    A ++T++  L F + EL+  P++  +LQ E+D V+ +K  + ++ L +++YL
Sbjct: 297 AQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356

Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413
             V+ E+LRL+P      R+ +++  I+GV +P    ++   Y +     Y+ +P  F P
Sbjct: 357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416

Query: 414 DR 415
           +R
Sbjct: 417 ER 418


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 123/503 (24%), Positives = 215/503 (42%), Gaps = 69/503 (13%)

Query: 5   LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGH-----LPCFWKKDE----- 54
           LLL G   LL +    +++ R R+R   IP  P P  L+G+     LP F ++       
Sbjct: 37  LLLCGLVALLGW----SWLRRRRAR--GIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSR 90

Query: 55  ----------VGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS-TKYN 103
                     +G +VL       A+ YG +    + H   V+++   SV++ L+   +  
Sbjct: 91  TRAAGIDPSVIGPQVL---LAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVF 147

Query: 104 KDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSL-METFNEKAE 162
            D      +  V  E+    G+V       W +QR+     FS S+L    +   + + +
Sbjct: 148 SDRPRVPLISIVTKEK----GVVFAHYGPVWRQQRK-----FSHSTLRHFGLGKLSLEPK 198

Query: 163 QLVEILEAKAD----GQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218
            + E    KA+    G+ P     +++    +I+    FG          K +   +   
Sbjct: 199 IIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRG 258

Query: 219 LEGITASRNTLAKFLP-------GKRKQLREVRESIR-FLRQVGRDWVQRRREALKRGEE 270
           LE    S+  L    P       G  K+LR++ + I  FL+++ +D     +E+L R  E
Sbjct: 259 LEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKD----HQESLDR--E 312

Query: 271 VPADILTQ-ILKAEEGAQ-------DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322
            P D +   +L  EE  +       D+E L       FIAG +T+ N L + ++ +S  P
Sbjct: 313 NPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNP 372

Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL-YPPAWGTFRLLEEETLID 381
           ++  ++  E++ VIG+ R     D  ++ Y    + E  RL          +  E T++ 
Sbjct: 373 DVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQ 432

Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIG 439
           G  +P  T +L + + + R    +E P  F P+RF    G    + T+ PF +G R C+G
Sbjct: 433 GYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMG 492

Query: 440 QQFAQMEVKVVMAKLLQRLEFRL 462
           +Q A+ME+ ++   L+Q   F L
Sbjct: 493 EQLAKMELFLMFVSLMQSFAFAL 515


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,057,705
Number of Sequences: 37866
Number of extensions: 925881
Number of successful extensions: 4580
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 4369
Number of HSP's gapped (non-prelim): 111
length of query: 500
length of database: 18,247,518
effective HSP length: 106
effective length of query: 394
effective length of database: 14,233,722
effective search space: 5608086468
effective search space used: 5608086468
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.