Search of human proteins with 5729718

Search of human proteins with 5729718

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729718 trophoblast glycoprotein [Homo sapiens]
         (420 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729718 trophoblast glycoprotein [Homo sapiens]                    840   0.0  
gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]          205   7e-53
gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]          205   7e-53
gi|169203012 PREDICTED: similar to hCG1820409 [Homo sapiens]          140   2e-33
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                118   9e-27
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           111   1e-24
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         107   3e-23
gi|194440719 chondroadherin-like [Homo sapiens]                       105   1e-22
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         101   1e-21
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   100   2e-21
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    99   9e-21
gi|51317373 netrin-G1 ligand [Homo sapiens]                            98   1e-20
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 97   3e-20
gi|198041768 synleurin [Homo sapiens]                                  95   1e-19
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    93   5e-19
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    93   5e-19
gi|225579152 insulin-like growth factor binding protein, acid la...    92   7e-19
gi|4826772 insulin-like growth factor binding protein, acid labi...    92   7e-19
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]                90   4e-18
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    89   6e-18
gi|150417978 platelet glycoprotein Ib alpha polypeptide precurso...    89   1e-17
gi|11321571 slit homolog 3 [Homo sapiens]                              89   1e-17
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                    87   3e-17
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    87   4e-17
gi|88702793 slit-like 2 [Homo sapiens]                                 86   5e-17
gi|188528675 slit homolog 1 [Homo sapiens]                             85   1e-16
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...    85   1e-16
gi|12007646 nyctalopin precursor [Homo sapiens]                        83   5e-16
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    83   5e-16
gi|4759146 slit homolog 2 [Homo sapiens]                               82   7e-16

>gi|5729718 trophoblast glycoprotein [Homo sapiens]
          Length = 420

 Score =  840 bits (2169), Expect = 0.0
 Identities = 420/420 (100%), Positives = 420/420 (100%)

Query: 1   MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD 60
           MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
Sbjct: 1   MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD 60

Query: 61  QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL 120
           QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
Sbjct: 61  QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL 120

Query: 121 AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL 180
           AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
Sbjct: 121 AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL 180

Query: 181 NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD 240
           NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
Sbjct: 181 NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD 240

Query: 241 LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC 300
           LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
Sbjct: 241 LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC 300

Query: 301 HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG 360
           HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
Sbjct: 301 HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG 360

Query: 361 IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV 420
           IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
Sbjct: 361 IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV 420


>gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score =  205 bits (521), Expect = 7e-53
 Identities = 157/391 (40%), Positives = 197/391 (50%), Gaps = 71/391 (18%)

Query: 48  LASAVSAQPPLPDQCPALCECSEAARTV-KCVN-RNLTEVPTDLPAYVRNLFLTGNQLAV 105
           L +A  +QP  P  CP  C C    + + +C +   L + P D+P   RNL + G  L V
Sbjct: 211 LVAAALSQPAAP--CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268

Query: 106 LPAGAFAR-----------RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
           L A AFA            R PL  L+AL L+ + ++ V  GAF+ LPSL  LDLSHNPL
Sbjct: 269 LRAAAFAGGDGDGDQAAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPL 326

Query: 155 ADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRR 214
             L   AF G  A       L  L LNH                  A +  G AL  L  
Sbjct: 327 RALGGGAFRGLPA-------LRSLQLNH------------------ALVRGGPAL--LAA 359

Query: 215 LELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH 274
           L+ A           LA L  LR L L+ N+L  L   + R L  LE L +  NAL  L 
Sbjct: 360 LDAA-----------LAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLD 407

Query: 275 NGTLAELQ---GLPHIRVFLDNNPWVCDCHMADMVTWLKE-TEVVQGKDRLTCAYPEKMR 330
              L  L+   GLP  R+ L +NP  C C    ++ WL+  TE V    RL CA P  + 
Sbjct: 408 PDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALL 467

Query: 331 NRVLLELNSADLDCDP-----------ILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRK 379
           +R LL+L+ A L C                P L+ SYVF G+VLALIG IFL+VLYLNR+
Sbjct: 468 DRPLLDLDGARLRCADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRR 527

Query: 380 GIKKWMHNIRDACRDHMEGYHYRYEINADPR 410
           GI++WM N+R+ACRD MEGYHYRYE +ADPR
Sbjct: 528 GIQRWMRNLREACRDQMEGYHYRYEQDADPR 558


>gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score =  205 bits (521), Expect = 7e-53
 Identities = 157/391 (40%), Positives = 197/391 (50%), Gaps = 71/391 (18%)

Query: 48  LASAVSAQPPLPDQCPALCECSEAARTV-KCVN-RNLTEVPTDLPAYVRNLFLTGNQLAV 105
           L +A  +QP  P  CP  C C    + + +C +   L + P D+P   RNL + G  L V
Sbjct: 211 LVAAALSQPAAP--CPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTV 268

Query: 106 LPAGAFAR-----------RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
           L A AFA            R PL  L+AL L+ + ++ V  GAF+ LPSL  LDLSHNPL
Sbjct: 269 LRAAAFAGGDGDGDQAAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPL 326

Query: 155 ADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRR 214
             L   AF G  A       L  L LNH                  A +  G AL  L  
Sbjct: 327 RALGGGAFRGLPA-------LRSLQLNH------------------ALVRGGPAL--LAA 359

Query: 215 LELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH 274
           L+ A           LA L  LR L L+ N+L  L   + R L  LE L +  NAL  L 
Sbjct: 360 LDAA-----------LAPLAELRLLGLAGNALSRLPPAALR-LARLEQLDVRLNALAGLD 407

Query: 275 NGTLAELQ---GLPHIRVFLDNNPWVCDCHMADMVTWLKE-TEVVQGKDRLTCAYPEKMR 330
              L  L+   GLP  R+ L +NP  C C    ++ WL+  TE V    RL CA P  + 
Sbjct: 408 PDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALL 467

Query: 331 NRVLLELNSADLDCDP-----------ILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRK 379
           +R LL+L+ A L C                P L+ SYVF G+VLALIG IFL+VLYLNR+
Sbjct: 468 DRPLLDLDGARLRCADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRR 527

Query: 380 GIKKWMHNIRDACRDHMEGYHYRYEINADPR 410
           GI++WM N+R+ACRD MEGYHYRYE +ADPR
Sbjct: 528 GIQRWMRNLREACRDQMEGYHYRYEQDADPR 558


>gi|169203012 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 339

 Score =  140 bits (354), Expect = 2e-33
 Identities = 80/166 (48%), Positives = 100/166 (60%), Gaps = 15/166 (9%)

Query: 260 LESLHLEDNALKVLHNGTLAELQ---GLPHIRVFLDNNPWVCDCHMADMVTWLKE-TEVV 315
           LE L +  NAL  L    L  L+   GLP  R+ L +NP  C C    ++ WL+  TE V
Sbjct: 154 LEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERV 213

Query: 316 QGKDRLTCAYPEKMRNRVLLELNSADLDCDP-----------ILPPSLQTSYVFLGIVLA 364
               RL CA P  + +R LL+L+ A L C                P L+ SYVF G+VLA
Sbjct: 214 PDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGEEAEAAGPELEASYVFFGLVLA 273

Query: 365 LIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPR 410
           LIG IFL+VLYLNR+GI++WM N+R+ACRD MEGYHYRYE +ADPR
Sbjct: 274 LIGLIFLMVLYLNRRGIQRWMRNLREACRDQMEGYHYRYEQDADPR 319


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  118 bits (296), Expect = 9e-27
 Identities = 102/320 (31%), Positives = 128/320 (40%), Gaps = 51/320 (15%)

Query: 54  AQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFAR 113
           A P     CP LC C  +  TV C   N + VP  LP   + LFL  N +  L  G F  
Sbjct: 23  ALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG- 81

Query: 114 RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN-PLADLSPFAFSGSNASVSAP 172
               + L  L L  + L  +  G F HL +L +LDL  N  L  L P  F G        
Sbjct: 82  ----SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQG-------- 129

Query: 173 SPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQ 232
             L  L   H+       Q  S  G +       R L  L+ L L  N  L+L  D+ A 
Sbjct: 130 --LERLQSLHLY----RCQLSSLPGNIF------RGLVSLQYLYLQENSLLHLQDDLFAD 177

Query: 233 LPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH----------------NG 276
           L +L HL L  N L  LT   FR L  L+ L L  N L+ +H                N 
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237

Query: 277 TLAELQG-----LPHIRVF-LDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMR 330
           +LA L G     LP +    L+ NPW CDC    +  W +   V      +TCA P + +
Sbjct: 238 SLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARV--SSSDVTCATPPERQ 295

Query: 331 NRVLLELNSADLD-CDPILP 349
            R L  L  AD   C P  P
Sbjct: 296 GRDLRALREADFQACPPAAP 315


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  111 bits (277), Expect = 1e-24
 Identities = 96/329 (29%), Positives = 143/329 (43%), Gaps = 45/329 (13%)

Query: 48  LASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLP 107
           +A+A SA P     CP++C CS     V C  R L+EVP  +P+  R L L  N + ++ 
Sbjct: 35  IAAAASAGP---QNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQ 91

Query: 108 AGAFARR---------------------PPLAELAALNLSGSRLDEVRAGAFEHLPSLRQ 146
           A  F                          LA L  L L  + L  + +GAFE+L  LR+
Sbjct: 92  ADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRE 151

Query: 147 LDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMV-VAALLA 205
           L L +NP+  +  +AF+        PS L+ L L  +   E   +  +FEG+  +  L  
Sbjct: 152 LWLRNNPIESIPSYAFN------RVPS-LMRLDLGELKKLEYISEG-AFEGLFNLKYLNL 203

Query: 206 GRA----------LQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFR 255
           G            L GL  LE++ NHF  +       L SL+ L + N+ +  +   +F 
Sbjct: 204 GMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFD 263

Query: 256 NLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVV 315
            L  L  L+L  N L  L +     L+ L  + + L +NPW CDC +  +  WL+E    
Sbjct: 264 GLASLVELNLAHNNLSSLPHDLFTPLRYL--VELHLHHNPWNCDCDILWLAWWLREYIPT 321

Query: 316 QGKDRLTCAYPEKMRNRVLLELNSADLDC 344
                  C  P  MR R L+E++ A   C
Sbjct: 322 NSTCCGRCHAPMHMRGRYLVEVDQASFQC 350


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  107 bits (266), Expect = 3e-23
 Identities = 97/324 (29%), Positives = 135/324 (41%), Gaps = 32/324 (9%)

Query: 48  LASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLP 107
           + SA     P    CP  C CS  A  V C  R+L EVP  +P   R L L  N + V+ 
Sbjct: 43  VTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIR 102

Query: 108 AGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFS---- 163
              F     L  L  L LS + + ++  GAF  LPSL  L+L  N L  +   AF     
Sbjct: 103 TDTFKH---LRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSK 159

Query: 164 ------GSNASVSAPSPLVELI--LNHIVPPEDER----QNRSFEGMV-VAALLAG---- 206
                  +N   S PS     +  L  +   E +R       +FEG+V +  L  G    
Sbjct: 160 LRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNL 219

Query: 207 ------RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHL 260
                  AL  L  LEL+ N    +       L SLR L L +  + ++   +F +L  L
Sbjct: 220 KDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSL 279

Query: 261 ESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDR 320
           E L+L  N L  L +     L  L   RV L++NPW C+C +  +  WLKET        
Sbjct: 280 EELNLSHNNLMSLPHDLFTPLHRLE--RVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCC 337

Query: 321 LTCAYPEKMRNRVLLELNSADLDC 344
             C  P  ++ R + EL+ +   C
Sbjct: 338 ARCHAPAGLKGRYIGELDQSHFTC 361


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  105 bits (261), Expect = 1e-22
 Identities = 102/349 (29%), Positives = 135/349 (38%), Gaps = 74/349 (21%)

Query: 54  AQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFAR 113
           A+     +CP  C C  + R V C  +NLTEVP  +P   + L L GN L V+PA AF  
Sbjct: 25  ARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQG 84

Query: 114 RP---------------------------------------------PLAELAALNLSGS 128
            P                                              L  L  L L G+
Sbjct: 85  VPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGN 144

Query: 129 RLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSG-----------SNASVSAPSPLVE 177
            L+E+R G F  L +L  L+L+HN L  L   AF G           +  SV AP  L  
Sbjct: 145 ALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAG 204

Query: 178 L-ILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSL 236
           L  L  +    +E Q  +  G V++        +GL RLEL  N   Y   +    LP L
Sbjct: 205 LPALRRLSLHHNELQ--ALPGPVLS------QARGLARLELGHNPLTYAGEEDGLALPGL 256

Query: 237 RHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHI-RVFLDNNP 295
           R L L   +L +L   +F +   L +L L  N L      TL  LQG   + R+ L  NP
Sbjct: 257 RELLLDGGALQALGPRAFAHCPRLHTLDLRGNQL-----DTLPPLQGPGQLRRLRLQGNP 311

Query: 296 WVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
             C C    ++ WL    V   +    C  P ++R   L  L   DL C
Sbjct: 312 LWCGCQARPLLEWLARARV---RSDGACQGPRRLRGEALDALRPWDLRC 357



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 94/337 (27%), Positives = 130/337 (38%), Gaps = 64/337 (18%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CP  C C   +R   C    L  VP   P+  + L L  N    +P  AF   P L  L 
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAF---PGLGHLV 452

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGS----------NASVSA 171
           +L+L    + E+ AGA   L  L  L LS N LA LS  A  G+          N  +  
Sbjct: 453 SLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQV 512

Query: 172 PS----PLVELILNHI-------VPPEDERQNRSFEGMVVA-------ALLAGRALQGLR 213
           P      L  L   H+       + P D  + R+   + ++       +L A    + L 
Sbjct: 513 PGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELE 572

Query: 214 RLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSF----RNLTH---------- 259
           +L L  N    +P   L  LP+L  L LS N L +L   +F    R+L H          
Sbjct: 573 KLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQ 632

Query: 260 ------------LESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVT 307
                       L+SLHL+ N L+ L    L  L  L  I   L +NP+ CDC +  +  
Sbjct: 633 ICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLELID--LSSNPFHCDCQLLPLHR 688

Query: 308 WLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
           WL    +  G    TCA P   R + +    +   DC
Sbjct: 689 WLTGLNLRVG---ATCATPPNARGQRVKAAAAVFEDC 722


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  101 bits (252), Expect = 1e-21
 Identities = 91/294 (30%), Positives = 121/294 (41%), Gaps = 57/294 (19%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CPA C C  A  TV+C    L  VP  +P   + LFL  N +A L  GA A   PLA L 
Sbjct: 23  CPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALA---PLAALR 77

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181
            L L  + L  + AGAF   P L +L L+ N L  L   AF G                 
Sbjct: 78  RLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG----------------- 120

Query: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241
                                      L  LR L LA N    L       LP L+ L L
Sbjct: 121 ---------------------------LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHL 153

Query: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCH 301
             NS+  L   +   L+ L  L L  N L  +    L  L  L  +R  L  NPW CDC 
Sbjct: 154 QENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLR--LTENPWRCDCA 211

Query: 302 MADMVTWLKE--TEVVQGKDR-LTCAYPEKMRNRVLLELNSADLDCDPILPPSL 352
           +  +  W+KE    ++  +DR + CA P ++  + LL+++ + L C   +PPS+
Sbjct: 212 LHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC---IPPSV 262


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  100 bits (250), Expect = 2e-21
 Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 78/283 (27%)

Query: 51  AVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGA 110
           AV A P     CP  C+C   +  V C    LT VP D+PA  R L L  N+L+ LP+ A
Sbjct: 32  AVEALPT----CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWA 87

Query: 111 FARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVS 170
           FA                           +L SL++LDLS+N L                
Sbjct: 88  FA---------------------------NLSSLQRLDLSNNFL---------------- 104

Query: 171 APSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVL 230
                             +R  RS  G           L  L  L+L +N    L RD+L
Sbjct: 105 ------------------DRLPRSIFG----------DLTNLTELQLRNNSIRTLDRDLL 136

Query: 231 AQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVF 290
              P LRHLDLS N L  L    F  L  L SL L  N L+ L   T   L  L  ++V 
Sbjct: 137 RHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQV- 195

Query: 291 LDNNPWVCDCHMADMVTWLKETEVVQGK-DRLTCAYPEKMRNR 332
             +NPW CDC++ +   W++      G+ D+L C  P+++R +
Sbjct: 196 -GDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGK 237


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 79/242 (32%), Positives = 110/242 (45%), Gaps = 25/242 (10%)

Query: 54  AQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFAR 113
           A PP    CPA CEC+   R V C  R LT VP  +PA  R L L+ N++  L  G  A 
Sbjct: 17  AAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAA 76

Query: 114 RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPS 173
            P L E   L+LS + +  V  GAF +LP LR L L  N L  + P  F+  +       
Sbjct: 77  LPALEE---LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT---- 129

Query: 174 PLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQL 233
            L++L  N                +V+      + L  LRRLE+  N  +++ R   A L
Sbjct: 130 -LLDLSENK---------------LVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173

Query: 234 PSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDN 293
            +L  L L   +L +L+  S  +L  L +L L   A+  L +     L GL H+ +  DN
Sbjct: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI--DN 231

Query: 294 NP 295
            P
Sbjct: 232 WP 233



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 95  NLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
           +L +T   +  +PA A   +   A L  LNLS + +  V  G+F  L  LR+L L+   L
Sbjct: 250 SLSVTHTNITAVPAAALRHQ---AHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALL 306

Query: 155 ADLSPFAFSG 164
           A + P AF G
Sbjct: 307 AVVEPQAFLG 316


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 88/317 (27%), Positives = 128/317 (40%), Gaps = 46/317 (14%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CP++C CS     V CV +NL EVP  +    R L L  NQ+ ++   +F     L  L 
Sbjct: 47  CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKH---LRHLE 103

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAF----------SGSNASVSA 171
            L LS + +  +  GAF  L +L  L+L  N L  +   AF            +N   S 
Sbjct: 104 ILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESI 163

Query: 172 PSPLVELI--LNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDV 229
           PS     I  L  +   E +R +   EG       A   L  LR L LA  +   +P   
Sbjct: 164 PSYAFNRIPSLRRLDLGELKRLSYISEG-------AFEGLSNLRYLNLAMCNLREIPN-- 214

Query: 230 LAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHI-- 287
           L  L  L  LDLS N L ++   SF+ L HL+ L +  + ++V+       LQ L  I  
Sbjct: 215 LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINL 274

Query: 288 --------------------RVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPE 327
                               R+ L +NPW C+C +  +  W+K+           C  P 
Sbjct: 275 AHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPP 334

Query: 328 KMRNRVLLELNSADLDC 344
            ++ R + EL+     C
Sbjct: 335 NLKGRYIGELDQNYFTC 351


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 84/286 (29%), Positives = 120/286 (41%), Gaps = 56/286 (19%)

Query: 52  VSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAF 111
           V+A+ PL   CP  C C  A  TV C   N   +P  +P     +FL  N++ +L  G F
Sbjct: 15  VAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHF 74

Query: 112 ARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN-PLADLSPFAFSGSNASVS 170
           +       +  L +  + +  +    FE    L +LDL  N  L  L+P  F G      
Sbjct: 75  S-----PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQG------ 123

Query: 171 APSPLVELILNHIVPPEDERQNRSFEGMVVAALLAG--RALQGLRRLELASNHFLYLPRD 228
               LV+L   ++                ++AL AG    L  L+ L L  NH  YL  D
Sbjct: 124 ----LVKLHALYLYK------------CGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDD 167

Query: 229 VLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH-------------- 274
           +   L +L HL L  N L SL   +FR L +L+ L L +N L+ +H              
Sbjct: 168 IFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLF 227

Query: 275 --NGTLAELQG--------LPHIRVFLDNNPWVCDCHMADMVTWLK 310
             N +L+ELQG        L  +R  L+ NPW C C    +  WL+
Sbjct: 228 LFNNSLSELQGECLAPLGALEFLR--LNGNPWDCGCRARSLWEWLQ 271


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 72/247 (29%), Positives = 112/247 (45%), Gaps = 29/247 (11%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L+ N +  +    F     L  LA L L  + L +V + AFE L SLR+L LSHN
Sbjct: 182 LRILDLSNNNILRISESGFQH---LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHN 238

Query: 153 PLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGL 212
           P+  + PFAF G               L +++      +N + +G           +  L
Sbjct: 239 PIEAIQPFAFKGL------------ANLEYLLLKNSRIRNVTRDGF--------SGINNL 278

Query: 213 RRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNL-THLESLHLEDNALK 271
           + L L+ N    L  D  + L +L +L L  N ++S+   +F N+   L+ L+L  N L 
Sbjct: 279 KHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLT 338

Query: 272 VLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRN 331
            LH   L  L  L H++   ++NPW C+C +  +  WL  + +      + C  P  MR 
Sbjct: 339 ALHPRVLKPLSSLIHLQA--NSNPWECNCKLLGLRDWLASSAITL---NIYCQNPPSMRG 393

Query: 332 RVLLELN 338
           R L  +N
Sbjct: 394 RALRYIN 400



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 64/254 (25%), Positives = 110/254 (43%), Gaps = 32/254 (12%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           C ++C+     R + C N  L+ +P + P     L+LTGN ++ +          L  L 
Sbjct: 32  CSSVCQLC-TGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELT---GLHSLV 87

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSG------SNASVSAPSPL 175
           AL L  S +  V   AF  L  L  L L++N +  L P  F G           +  S +
Sbjct: 88  ALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFV 147

Query: 176 VELILNHIVPPE--DERQNR-------SFEGMVVAALL-------------AGRALQGLR 213
              + N +V  +  + ++NR       +F GMV   +L               + L+ L 
Sbjct: 148 PRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLA 207

Query: 214 RLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVL 273
            L L SN+   +P +    L SLR L LS+N + ++   +F+ L +LE L L+++ ++ +
Sbjct: 208 CLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNV 267

Query: 274 HNGTLAELQGLPHI 287
                + +  L H+
Sbjct: 268 TRDGFSGINNLKHL 281



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 22/81 (27%), Positives = 40/81 (49%)

Query: 209 LQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDN 268
           L  L  L L +++ LY+      QL  L  L L+NN +  L    F+ L +L +L+L+ N
Sbjct: 83  LHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYN 142

Query: 269 ALKVLHNGTLAELQGLPHIRV 289
            +  +  G   +L  + ++ +
Sbjct: 143 QVSFVPRGVFNDLVSVQYLNL 163


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 85/302 (28%), Positives = 121/302 (40%), Gaps = 81/302 (26%)

Query: 58  LPDQCPALCECSE--AARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRP 115
           L   CP  C+C E    +   C  R+L  VP   PA V  L L+ N+L  LP GAF R  
Sbjct: 15  LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF-REV 73

Query: 116 PLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPL 175
           PL  L +L L+ + +  V AGA   L  L+ LDLSHN ++D   FA+S  +         
Sbjct: 74  PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISD---FAWSDLHN-------- 120

Query: 176 VELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPS 235
                                            L  L+ L++ SN   ++PRD    L +
Sbjct: 121 ---------------------------------LSALQLLKMDSNELTFIPRDAFRSLRA 147

Query: 236 LRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNP 295
           LR L L++N L +L                          GT   L  L H+++  + NP
Sbjct: 148 LRSLQLNHNRLHTLA------------------------EGTFTPLTALSHLQI--NENP 181

Query: 296 WVCDCHMADMVTWLKETEV-VQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQT 354
           + C C +  + TW   T V +  +D + C  P  ++   L  L        P   PS+Q 
Sbjct: 182 FDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPL-----PCSAPSVQL 236

Query: 355 SY 356
           SY
Sbjct: 237 SY 238


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 85/302 (28%), Positives = 121/302 (40%), Gaps = 81/302 (26%)

Query: 58  LPDQCPALCECSE--AARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRP 115
           L   CP  C+C E    +   C  R+L  VP   PA V  L L+ N+L  LP GAF R  
Sbjct: 15  LAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF-REV 73

Query: 116 PLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPL 175
           PL  L +L L+ + +  V AGA   L  L+ LDLSHN ++D   FA+S  +         
Sbjct: 74  PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISD---FAWSDLHN-------- 120

Query: 176 VELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPS 235
                                            L  L+ L++ SN   ++PRD    L +
Sbjct: 121 ---------------------------------LSALQLLKMDSNELTFIPRDAFRSLRA 147

Query: 236 LRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNP 295
           LR L L++N L +L                          GT   L  L H+++  + NP
Sbjct: 148 LRSLQLNHNRLHTLA------------------------EGTFTPLTALSHLQI--NENP 181

Query: 296 WVCDCHMADMVTWLKETEV-VQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQT 354
           + C C +  + TW   T V +  +D + C  P  ++   L  L        P   PS+Q 
Sbjct: 182 FDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPL-----PCSAPSVQL 236

Query: 355 SY 356
           SY
Sbjct: 237 SY 238


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 86/282 (30%), Positives = 119/282 (42%), Gaps = 41/282 (14%)

Query: 21  LALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQ-----CPALCECS----EA 71
           LAL+LL WV+                   S   A P  P +     CPA C CS      
Sbjct: 48  LALLLLSWVALGP---------------RSLEGADPGTPGEAEGPACPAACVCSYDDDAD 92

Query: 72  ARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLD 131
             +V C +RNLT +P  +P   + L+L GN L+ +P  AF     L+ L  LNL G +L 
Sbjct: 93  ELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQN---LSSLGFLNLQGGQLG 149

Query: 132 EVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDER- 190
            +   A   L +L  L L  N L  L+   F+ + A  S     + L  N +   ED   
Sbjct: 150 SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS-----LGLSNNRLSRLEDGLF 204

Query: 191 --------QNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLS 242
                    N  +  + V    A R L  LR L LA N   YL   + + L  LR LDLS
Sbjct: 205 EGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLS 264

Query: 243 NNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGL 284
            N+L ++    F  L  L+ L+L+ N +  +  G    L+ L
Sbjct: 265 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL 306



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 71/230 (30%), Positives = 106/230 (46%), Gaps = 33/230 (14%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L GN+LA L    F+    LAEL  L+LS + L  ++A  F  LP L++L L  N
Sbjct: 234 LRELVLAGNRLAYLQPALFSG---LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 290

Query: 153 PLADLSPFAFSGSNA------SVSAPSPLVE-----------LILNH----IVPPEDERQ 191
            +A ++P AF G  A      S +  + L+E           L L+H     + P   + 
Sbjct: 291 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 350

Query: 192 NRSFEGMVVA----ALLAGRALQGLRRLELAS---NHFLYLPRDVLAQLPSLRHLDLSNN 244
               E + +       LA R+ +GL +LE+ +   N    +       L ++  ++LS N
Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410

Query: 245 SLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNN 294
            L +L    FR L  L SLHLE + L  +   T   L GL   R+FL +N
Sbjct: 411 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR--RLFLKDN 458



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 69/256 (26%), Positives = 95/256 (37%), Gaps = 53/256 (20%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L+ N +A L    F     L  L  L L  +R+ ++   +FE L  L  L L HN
Sbjct: 330 LRVLRLSHNAIASLRPRTFK---DLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 386

Query: 153 PLADLSPFAFSG------SNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAG 206
            L ++   AF G       N S +    L E +   +          S  G +      G
Sbjct: 387 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 446

Query: 207 RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHL- 265
             L GLRRL L  N  + +    L  L  L  LDL++N L  L +  F+ L  LE L L 
Sbjct: 447 --LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 504

Query: 266 -----------------------EDNALKVLHNGTLAELQGLPHI--------------- 287
                                    N L+ L N  LA L  L ++               
Sbjct: 505 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPP 564

Query: 288 ---RVFLDNNPWVCDC 300
              R++L+ NPW C C
Sbjct: 565 GLERLWLEGNPWDCGC 580



 Score = 33.1 bits (74), Expect = 0.48
 Identities = 28/67 (41%), Positives = 33/67 (49%), Gaps = 3/67 (4%)

Query: 91  AYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLS 150
           A +  L LT NQL  LP   F     L +L  L LS +RL E+ A A   L     LD+S
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQG---LGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 528

Query: 151 HNPLADL 157
           HN L  L
Sbjct: 529 HNRLEAL 535


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 86/282 (30%), Positives = 119/282 (42%), Gaps = 41/282 (14%)

Query: 21  LALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQ-----CPALCECS----EA 71
           LAL+LL WV+                   S   A P  P +     CPA C CS      
Sbjct: 10  LALLLLSWVALGP---------------RSLEGADPGTPGEAEGPACPAACVCSYDDDAD 54

Query: 72  ARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLD 131
             +V C +RNLT +P  +P   + L+L GN L+ +P  AF     L+ L  LNL G +L 
Sbjct: 55  ELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQN---LSSLGFLNLQGGQLG 111

Query: 132 EVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDER- 190
            +   A   L +L  L L  N L  L+   F+ + A  S     + L  N +   ED   
Sbjct: 112 SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS-----LGLSNNRLSRLEDGLF 166

Query: 191 --------QNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLS 242
                    N  +  + V    A R L  LR L LA N   YL   + + L  LR LDLS
Sbjct: 167 EGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLS 226

Query: 243 NNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGL 284
            N+L ++    F  L  L+ L+L+ N +  +  G    L+ L
Sbjct: 227 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL 268



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 71/230 (30%), Positives = 106/230 (46%), Gaps = 33/230 (14%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L GN+LA L    F+    LAEL  L+LS + L  ++A  F  LP L++L L  N
Sbjct: 196 LRELVLAGNRLAYLQPALFSG---LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 252

Query: 153 PLADLSPFAFSGSNA------SVSAPSPLVE-----------LILNH----IVPPEDERQ 191
            +A ++P AF G  A      S +  + L+E           L L+H     + P   + 
Sbjct: 253 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 312

Query: 192 NRSFEGMVVA----ALLAGRALQGLRRLELAS---NHFLYLPRDVLAQLPSLRHLDLSNN 244
               E + +       LA R+ +GL +LE+ +   N    +       L ++  ++LS N
Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372

Query: 245 SLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNN 294
            L +L    FR L  L SLHLE + L  +   T   L GL   R+FL +N
Sbjct: 373 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR--RLFLKDN 420



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 69/256 (26%), Positives = 95/256 (37%), Gaps = 53/256 (20%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L+ N +A L    F     L  L  L L  +R+ ++   +FE L  L  L L HN
Sbjct: 292 LRVLRLSHNAIASLRPRTFK---DLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 348

Query: 153 PLADLSPFAFSG------SNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAG 206
            L ++   AF G       N S +    L E +   +          S  G +      G
Sbjct: 349 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTG 408

Query: 207 RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHL- 265
             L GLRRL L  N  + +    L  L  L  LDL++N L  L +  F+ L  LE L L 
Sbjct: 409 --LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 466

Query: 266 -----------------------EDNALKVLHNGTLAELQGLPHI--------------- 287
                                    N L+ L N  LA L  L ++               
Sbjct: 467 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPP 526

Query: 288 ---RVFLDNNPWVCDC 300
              R++L+ NPW C C
Sbjct: 527 GLERLWLEGNPWDCGC 542



 Score = 33.1 bits (74), Expect = 0.48
 Identities = 28/67 (41%), Positives = 33/67 (49%), Gaps = 3/67 (4%)

Query: 91  AYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLS 150
           A +  L LT NQL  LP   F     L +L  L LS +RL E+ A A   L     LD+S
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQG---LGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490

Query: 151 HNPLADL 157
           HN L  L
Sbjct: 491 HNRLEAL 497


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 86/276 (31%), Positives = 112/276 (40%), Gaps = 29/276 (10%)

Query: 96  LFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN--- 152
           L L GN L  LP   FA   PL  L  L+L  +R+  +   AF  L  LR L+LS N   
Sbjct: 160 LRLDGNALGALPDAVFA---PLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216

Query: 153 ----------PLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAA 202
                     PL  LS    S +N     P      I  H+  P     +     +   A
Sbjct: 217 PSLRHAATFAPLRSLSSLILSANNLQHLGPR-----IFQHL--PRLGLLSLRGNQLTHLA 269

Query: 203 LLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLES 262
             A   L+ LR L L  N    LP  +L  L SL  LDLS N L +L   +F +L  L  
Sbjct: 270 PEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRE 329

Query: 263 LHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGK---D 319
           L L +NAL  L     A    L   R+ LD N W CDC +  +  W+ +    QG+    
Sbjct: 330 LSLRNNALSALSGDIFAASPAL--YRLDLDGNGWTCDCRLRGLKRWMGDWH-SQGRLLTV 386

Query: 320 RLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTS 355
            + C +P  +R + L  L+   L       PS   S
Sbjct: 387 FVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSAS 422



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 62/229 (27%), Positives = 84/229 (36%), Gaps = 45/229 (19%)

Query: 54  AQPPLPDQ-CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFA 112
           A PPL +  CP  C+C      + C NR L  VP                         +
Sbjct: 18  ALPPLAEPVCPERCDCQHPQHLL-CTNRGLRVVPKT-----------------------S 53

Query: 113 RRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAP 172
             P   ++   +L G+ +  + A  F  L  LR+LDL +N +  L P  F          
Sbjct: 54  SLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKL------- 106

Query: 173 SPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQ 232
           S L EL L           N   + +    L     L+ LR L    N    L R     
Sbjct: 107 SRLEELYLG----------NNLLQALAPGTLAP---LRKLRILYANGNEISRLSRGSFEG 153

Query: 233 LPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAEL 281
           L SL  L L  N+L +L    F  L +L  LHLE N ++ L     A+L
Sbjct: 154 LESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQL 202



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/53 (45%), Positives = 32/53 (60%)

Query: 232 QLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGL 284
           +L  LR LDL  N + SL   +F  L+ LE L+L +N L+ L  GTLA L+ L
Sbjct: 81  RLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKL 133



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 27/83 (32%), Positives = 36/83 (43%), Gaps = 2/83 (2%)

Query: 212 LRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALK 271
           LRRL+L  N    L      +L  L  L L NN L +L   +   L  L  L+   N + 
Sbjct: 85  LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIS 144

Query: 272 VLHNGTLAELQGLPHIRVFLDNN 294
            L  G+   L+ L  +R  LD N
Sbjct: 145 RLSRGSFEGLESLVKLR--LDGN 165


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 85/277 (30%), Positives = 121/277 (43%), Gaps = 46/277 (16%)

Query: 18  LARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKC 77
           L  L  + LG + S+ P+ +A                 PPL   C A C C +  R V C
Sbjct: 5   LGLLCFLALGLLGSAGPSGAA-----------------PPL---CAAPCSC-DGDRRVDC 43

Query: 78  VNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGA 137
             + LT VP  L A+ + L ++ N +  LP  AF   P L EL    L+G+ L  +   A
Sbjct: 44  SGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL---QLAGNDLSFIHPKA 100

Query: 138 FEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVP-PEDERQNRSFE 196
              L  L+ L L +N L  +   A  G +A  S     + L  NHI   PED     SFE
Sbjct: 101 LSGLKELKVLTLQNNQLKTVPSEAIRGLSALQS-----LRLDANHITSVPED-----SFE 150

Query: 197 GMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRN 256
           G+V            LR L L  N    +P   L+ LP+L+ L L+ N + S+   +F N
Sbjct: 151 GLVQ-----------LRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTN 199

Query: 257 LTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDN 293
           L+ L  LHL +N ++ L       L  L  + +  +N
Sbjct: 200 LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 44/193 (22%), Positives = 74/193 (38%), Gaps = 6/193 (3%)

Query: 81  NLTEVPTDLPAY--VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAF 138
           NL E P  + A   ++ L    N ++V+P GAF   P L     ++L  + L  V   AF
Sbjct: 236 NLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR---TIHLYDNPLSFVGNSAF 292

Query: 139 EHLPSLRQLDLSHNPLADLSPFAFSGSNA-SVSAPSPLVELILNHIVPPEDERQNRSFEG 197
            +L  L  L +    +    P      +  S++     +  I N++   +   +      
Sbjct: 293 HNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSY 352

Query: 198 MVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNL 257
             +  L +      L  + L  N    +       L SLR LDLS N +  +   +F  L
Sbjct: 353 NNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATL 412

Query: 258 THLESLHLEDNAL 270
             + +L +  N L
Sbjct: 413 GPITNLDVSFNEL 425



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 22/142 (15%)

Query: 120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELI 179
           L +L L+G+++  +     +    LR LDLS+N + DL   +F+G +A        + L 
Sbjct: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEE-----ISLQ 373

Query: 180 LNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHL 239
            N I     + +  +F+G++            LR L+L+ N    +     A L  + +L
Sbjct: 374 RNQIY----QIKEGTFQGLI-----------SLRILDLSRNLIHEIHSRAFATLGPITNL 418

Query: 240 DLSNNSLVSLTYVSFRNLTHLE 261
           D+S N L S        L  L+
Sbjct: 419 DVSFNELTSFPTEGLNGLNQLK 440


>gi|150417978 platelet glycoprotein Ib alpha polypeptide precursor
           [Homo sapiens]
          Length = 639

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 81/257 (31%), Positives = 108/257 (42%), Gaps = 31/257 (12%)

Query: 57  PLPDQCPALCECSEAAR--TVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARR 114
           P P     +CE S+ A    V C  RNLT +P DLP     L L+ N L      + A  
Sbjct: 11  PSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTF---SLATL 67

Query: 115 PPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSP 174
            P   L  LNL    L +++      LP L  LDLSHN L  L                P
Sbjct: 68  MPYTRLTQLNLDRCELTKLQVDGT--LPVLGTLDLSHNQLQSL----------------P 109

Query: 175 LVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLP 234
           L+   L     P     + SF  +    L A R L  L+ L L  N    LP  +L   P
Sbjct: 110 LLGQTL-----PALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTP 164

Query: 235 SLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNN 294
            L  L L+NN+L  L       L +L++L L++N+L  +  G       LP    FL  N
Sbjct: 165 KLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGS-HLLPF--AFLHGN 221

Query: 295 PWVCDCHMADMVTWLKE 311
           PW+C+C +     WL++
Sbjct: 222 PWLCNCEILYFRRWLQD 238


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 80/294 (27%), Positives = 123/294 (41%), Gaps = 76/294 (25%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CP  C C      V C N+ L  +P+ LP YV +L L  N+++VL A             
Sbjct: 505 CPEKCRCE--GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA------------- 549

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181
                         G F+ LP+LR+++LS+N + ++   AF G+ ASV       EL+L 
Sbjct: 550 -------------TGIFKKLPNLRKINLSNNKIKEVREGAFDGA-ASVQ------ELMLT 589

Query: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241
                    Q  +  G V       R L GL+ L L SN    +  D  A L S+R L L
Sbjct: 590 -------GNQLETVHGRVF------RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSL 636

Query: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCH 301
            +N + ++T  +F  L  L +++L                           +NP+ C+CH
Sbjct: 637 YDNRITTITPGAFTTLVSLSTINLL--------------------------SNPFNCNCH 670

Query: 302 MADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTS 355
           +A +  WL++  +V G  R  C  P  ++   + ++   D  CD     S Q S
Sbjct: 671 LAWLGKWLRKRRIVSGNPR--CQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLS 722



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 70/302 (23%), Positives = 121/302 (40%), Gaps = 81/302 (26%)

Query: 47  FLASAVSAQPPLPD----QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQ 102
           ++  A  ++PP  +     CP+ C CS     V C  + L E+P +LP  +  + L  N 
Sbjct: 261 YVCPAPHSEPPSCNANSISCPSPCTCSN--NIVDCRGKGLMEIPANLPEGIVEIRLEQNS 318

Query: 103 LAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAF 162
           +  +PAGAF +                              L+++D+S N ++D++P AF
Sbjct: 319 IKAIPAGAFTQ---------------------------YKKLKRIDISKNQISDIAPDAF 351

Query: 163 SGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHF 222
            G                                            L+ L  L L  N  
Sbjct: 352 QG--------------------------------------------LKSLTSLVLYGNKI 367

Query: 223 LYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQ 282
             + + +   L SL+ L L+ N +  L   +F++L +L  L L DN L+ +  G  A LQ
Sbjct: 368 TEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQ 427

Query: 283 GLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADL 342
            +  +   L  NP+VCDCH+  +  +L++  +     R  C+ P ++ N+ + ++ S   
Sbjct: 428 SIQTLH--LAQNPFVCDCHLKWLADYLQDNPIETSGAR--CSSPRRLANKRISQIKSKKF 483

Query: 343 DC 344
            C
Sbjct: 484 RC 485



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 72/297 (24%), Positives = 114/297 (38%), Gaps = 55/297 (18%)

Query: 48  LASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLP 107
           LAS +S  P +   CP  C CS A+  V C    L  VP  +P     L L  N +  + 
Sbjct: 22  LASVLSGPPAVA--CPTKCTCSAAS--VDCHGLGLRAVPRGIPRNAERLDLDRNNITRIT 77

Query: 108 AGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNA 167
              FA    L  L  L+L  +++  +  GAF+ L  L +L L+ N L  L    F  +  
Sbjct: 78  KMDFAG---LKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQST-- 132

Query: 168 SVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPR 227
                             P+  R + S   +      A R +  ++ L+L +NH   +  
Sbjct: 133 ------------------PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIED 174

Query: 228 DVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHI 287
                L  L  L L+NN++  +   SF ++  + +L L  N L                 
Sbjct: 175 GAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL----------------- 217

Query: 288 RVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
                     CDCH+A +  WL++   V G+  L C  P  +R   + ++   +  C
Sbjct: 218 ---------YCDCHLAWLSDWLRQRRTV-GQFTL-CMAPVHLRGFNVADVQKKEYVC 263



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 93/354 (26%), Positives = 131/354 (37%), Gaps = 90/354 (25%)

Query: 73  RTVKCVNRNLTEVPT---DLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAA------- 122
           R +   N  + EV     D  A V+ L LTGNQL  +    F     L  L         
Sbjct: 560 RKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGC 619

Query: 123 --------------LNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGS--- 165
                         L+L  +R+  +  GAF  L SL  ++L  NP       A+ G    
Sbjct: 620 VSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLR 679

Query: 166 -------NASVSAPSPLVELILNHI----------------VPPEDERQNRSFEGMVVAA 202
                  N     P  L E+ +  +                + P    Q    E +V  +
Sbjct: 680 KRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCS 739

Query: 203 LLAGRAL-----QGLRRLELASNHFLYLPRDVLAQLPSLRHL---DLSNNSLVSLTYVSF 254
               RAL     + +  L L  NH   +PR+    L +LRHL   DLSNNS+  LT  +F
Sbjct: 740 NKGLRALPRGMPKDVTELYLEGNHLTAVPRE----LSALRHLTLIDLSNNSISMLTNYTF 795

Query: 255 RNLTHLESLHLEDNALK----------------VLH--------NGTLAELQGLPHIRVF 290
            N++HL +L L  N L+                 LH         G+  +L  L H+   
Sbjct: 796 SNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLA-- 853

Query: 291 LDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
           L  NP  CDC +  +  W+K      G  R  C+ PE M +R+LL   +    C
Sbjct: 854 LGTNPLHCDCSLRWLSEWVKAGYKEPGIAR--CSSPEPMADRLLLTTPTHRFQC 905



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 58  LPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPL 117
           L  +CP  C C E    V+C N+ L  +P  +P  V  L+L GN L  +P    A    L
Sbjct: 721 LSPRCPEQCTCMETV--VRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSA----L 774

Query: 118 AELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSG 164
             L  ++LS + +  +    F ++  L  L LS+N L  +   AF+G
Sbjct: 775 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNG 821


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 94/304 (30%), Positives = 126/304 (41%), Gaps = 39/304 (12%)

Query: 81  NLTEVPTDL---PAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGA 137
           NLT +P  L    A +  L L  N+L  L +G       L  L  L    + +  +  GA
Sbjct: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNS---LGALTELQFHRNHIRSIAPGA 237

Query: 138 FEHLPSLRQLDLSHNPLADLSPFAFSGS----------NASVSAPSPLV-------ELIL 180
           F+ LP+L  L LS N LA L    F  S          N     P  L        EL L
Sbjct: 238 FDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWL 297

Query: 181 NHI---VPPEDERQNRS---FEGMVVAALLAGR---ALQGLRRLE---LASNHFLYLPRD 228
           N       P    +N S   + G+ ++  L+     A QGL  L+   L SN    LP  
Sbjct: 298 NRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDG 357

Query: 229 VLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIR 288
           +L  L  LR + L  N L +L    FRNL+ LES+ L+ N L+ L       L  L    
Sbjct: 358 LLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRL--TE 415

Query: 289 VFLDNNPWVCDCHMADMVTWLKE-TEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC-DP 346
           V L +N W CDC +   + WL++   +V G++   CA P       L  L   D +C  P
Sbjct: 416 VLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGP 475

Query: 347 ILPP 350
             PP
Sbjct: 476 RGPP 479



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 61/242 (25%), Positives = 101/242 (41%), Gaps = 31/242 (12%)

Query: 59  PDQCPALCEC--SEAARTVKCVNRNLTEVPT-DLPAYVRNLFLTGNQLAVLPAGAFARRP 115
           P  CP  C+C   +AA+   C   ++  +    LP  + ++ L G    VL + +F+   
Sbjct: 18  PFPCPPACKCVFRDAAQ---CSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSG-- 72

Query: 116 PLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPL 175
            +  L  L +S S +  V  G F  L  L+ L LS N +  L         A +     L
Sbjct: 73  -MTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLP-------GALLDKMVLL 124

Query: 176 VELILNH-------------IVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHF 222
            +L L+H             +V  ++   N++    + A+L     L+ L+ L+L+ N+ 
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTN--LENLKLLDLSGNNL 182

Query: 223 LYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQ 282
            +LP+ +L     L  L L +N LVSL      +L  L  L    N ++ +  G    L 
Sbjct: 183 THLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLP 242

Query: 283 GL 284
            L
Sbjct: 243 NL 244



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 62/220 (28%), Positives = 93/220 (42%), Gaps = 30/220 (13%)

Query: 73  RTVKCVNRNLTEVP---TDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSR 129
           +T++     +T +P    D    +  LFL  N L  +    F +   L ELA   L+ ++
Sbjct: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELA---LNQNQ 157

Query: 130 LDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDE 189
           LD + A  F +L +L+ LDLS N L  L P    G+ A +       E +L H       
Sbjct: 158 LDFLPASLFTNLENLKLLDLSGNNLTHL-PKGLLGAQAKL-------ERLLLH------- 202

Query: 190 RQNRSFEGMVVAALLAG--RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLV 247
             NR      + +L +G   +L  L  L+   NH   +      +LP+L  L LS N L 
Sbjct: 203 -SNR------LVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLA 255

Query: 248 SLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHI 287
            L    F +  +L  L L +N L  L      E+ GL  +
Sbjct: 256 FLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQEL 295


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 83/286 (29%), Positives = 116/286 (40%), Gaps = 43/286 (15%)

Query: 92  YVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSH 151
           +++ L L  N LA LP   F    PL  L  L LS + L  +  G F  L SL++L L  
Sbjct: 170 HLKTLNLAQNLLAQLPEELFH---PLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDS 226

Query: 152 NPLADLSPFAFSG----------SNASVSAPSPLVELILN-----------HIVPPEDER 190
           N +++L P  FS            NA    P  +   + N            ++P     
Sbjct: 227 NNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFA 286

Query: 191 QNRSFEGMVVAALLAGRALQG-------LRRLELASNHFLYLPRDVLAQLPSLRHLDLSN 243
                 G+ +         +G       LR L L+ N   +LP  +   L  L  L L +
Sbjct: 287 HTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGS 346

Query: 244 NSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMA 303
           N+L +L    F+NL+ LE L L  N L  L  G       L    + L  NPW CDCH+A
Sbjct: 347 NNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL--FNLALHGNPWQCDCHLA 404

Query: 304 DMVTWLKETEVVQGKDRLT-----CAYPEKMRNRVLLELNSADLDC 344
            +  WL+     Q  DRL      CA P  ++ +V+  LN   L C
Sbjct: 405 YLFNWLQ-----QYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 72/249 (28%), Positives = 110/249 (44%), Gaps = 21/249 (8%)

Query: 54  AQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFAR 113
           A+P  P  CP  C+C    + V C +  L  VP D+P Y +N+         L   AF  
Sbjct: 16  ARPAQP--CPMGCDCF--VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGS 71

Query: 114 RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNA------ 167
            P L ++  LN   ++L + R  AF  LP L  L+++ +   +LS   FS   +      
Sbjct: 72  NPNLTKVVFLN---TQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTL 128

Query: 168 SVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAG--RALQGLRRLELASNHFLYL 225
           + +    L E +  H+   E    +   +G  + AL     + L  L+ L LA N    L
Sbjct: 129 NFNMLEALPEGLFQHLAALE----SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184

Query: 226 PRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
           P ++   L SL+ L LSNN+L  L    F  L  L+ L L+ N +  L     ++L  L 
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244

Query: 286 HIRVFLDNN 294
             R++L  N
Sbjct: 245 --RLWLQRN 251


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 92/335 (27%), Positives = 145/335 (43%), Gaps = 61/335 (18%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRP------ 115
           CP+ C+CS+  +TV C  R  T VP D+P     L++  N + +L AG+FA  P      
Sbjct: 24  CPSGCQCSQP-QTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLD 82

Query: 116 ---------------PLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPF 160
                          PLA L+ L+L+ +RL E+    F  L  L +L L  N +  + P 
Sbjct: 83  LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPG 142

Query: 161 AFSG---------SNASVSAPSP-------LVELILNHIVPPEDERQNRSFEGMVVAALL 204
           AF            +  + A  P       L++L  N ++  E    + +    V A  L
Sbjct: 143 AFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGILDTA---NVEALRL 199

Query: 205 AGRALQ-----------GLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNS-LVSLTYV 252
           AG  LQ            L  L+++ N    +P  V+  L  L  L L+ N+ +  L   
Sbjct: 200 AGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIRGLRGLTRLRLAGNTRIAQLRPE 258

Query: 253 SFRNLTHLESLHLEDNALKVLHNGTLAELQGL-PHIRVF-LDNNPWVCDCHMADMVTWLK 310
               L  L+ L + + +L+ L      +L GL P +R+     NP+ C C ++    W++
Sbjct: 259 DLAGLAALQELDVSNLSLQALP----GDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVR 314

Query: 311 ETEV-VQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
           E+ V +   +   C +P K   R+LLEL+ AD  C
Sbjct: 315 ESHVTLASPEETRCHFPPKNAGRLLLELDYADFGC 349


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 75/306 (24%), Positives = 120/306 (39%), Gaps = 77/306 (25%)

Query: 39  SSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFL 98
           S FS S    A  V         CPA+C CS     V C  + LT +P +LP  +  + L
Sbjct: 259 SEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGI--VDCRGKGLTAIPANLPETMTEIRL 316

Query: 99  TGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLS 158
             N +  +P GAF+                               LR++DLS+N +A+++
Sbjct: 317 ELNGIKSIPPGAFSP---------------------------YRKLRRIDLSNNQIAEIA 349

Query: 159 PFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELA 218
           P AF G                                            L+ L  L L 
Sbjct: 350 PDAFQG--------------------------------------------LRSLNSLVLY 365

Query: 219 SNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTL 278
            N    LPR V   L +L+ L L+ N +  +   +F++L +L  L L DN ++ L  GT 
Sbjct: 366 GNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTF 425

Query: 279 AELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELN 338
             L+ +  +   L  NP++CDC++  +  +L+   +     R  CA P ++ N+ + ++ 
Sbjct: 426 TSLRAIQTLH--LAQNPFICDCNLKWLADFLRTNPIETSGAR--CASPRRLANKRIGQIK 481

Query: 339 SADLDC 344
           S    C
Sbjct: 482 SKKFRC 487



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 69/284 (24%), Positives = 114/284 (40%), Gaps = 76/284 (26%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CP  C C   A  V+C +  LT++P  +P     L L  N++++L A    ++  L  L 
Sbjct: 513 CPHKCRCE--ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKK--LTHLK 568

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181
            +NLS +++ E+  GAFE   S+ +L L+ N L  +    F                   
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMF------------------- 609

Query: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241
                                    R L GLR L L +N    +  D    L ++R L L
Sbjct: 610 -------------------------RGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSL 644

Query: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCH 301
            +N + +++  +F  L  L +L+L            LA              NP+ C+C 
Sbjct: 645 YDNQITTVSPGAFDTLQSLSTLNL------------LA--------------NPFNCNCQ 678

Query: 302 MADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCD 345
           +A +  WL++ ++V G  R  C  P+ +R   L ++   D  C+
Sbjct: 679 LAWLGGWLRKRKIVTGNPR--CQNPDFLRQIPLQDVAFPDFRCE 720



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 80/316 (25%), Positives = 127/316 (40%), Gaps = 66/316 (20%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           +R L L  N+++ +   +F     L  +  L+L  +++  V  GAF+ L SL  L+L  N
Sbjct: 615 LRTLMLRNNRISCIHNDSFTG---LRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671

Query: 153 PLADLSPFAFSG----------SNASVSAPSPLVELILNHIVPPEDERQNRSFEG----- 197
           P       A+ G           N     P  L ++ L  +  P+   +    EG     
Sbjct: 672 PFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPR 731

Query: 198 ------------MVVAALLAGRAL-----QGLRRLELASNHFLYLPRDVLAQLPSLRHLD 240
                       +V  +    RAL     + +  L L  N F  +P   L+    L+ +D
Sbjct: 732 PQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLVD 790

Query: 241 LSNNSLVSLTYVSFRNLTHLESLHLEDNALK------------------------VLHNG 276
           LSNN + SL+  SF N++ L +L L  NAL+                         L  G
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850

Query: 277 TLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLE 336
             A++  L H+ +    NP  CDCH+  + +W+K      G  R  CA P+ M  ++LL 
Sbjct: 851 IFADVTSLSHLAI--GANPLYCDCHLRWLSSWVKTGYKEPGIAR--CAGPQDMEGKLLLT 906

Query: 337 LNSADLDCDPILPPSL 352
             +   +C    PP+L
Sbjct: 907 TPAKKFECQG--PPTL 920



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 72/322 (22%), Positives = 115/322 (35%), Gaps = 68/322 (21%)

Query: 27  GWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVP 86
           GW SS+ P          A       SA       CPALC C+    TV C    L  +P
Sbjct: 6   GWGSSAGPVRPELWLLLWAAAWRLGASA-------CPALCTCT--GTTVDCHGTGLQAIP 56

Query: 87  TDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQ 146
            ++P     L L GN +  +    FA    L +L  L L  +++  V  GAF+ +  L +
Sbjct: 57  KNIPRNTERLELNGNNITRIHKNDFAG---LKQLRVLQLMENQIGAVERGAFDDMKELER 113

Query: 147 LDLSHNPLADLSPFAFSGSNA--SVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALL 204
           L L+ N L  L    F  + A   +      ++ I         + +N   +   ++ + 
Sbjct: 114 LRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIE 173

Query: 205 AG--RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLES 262
            G  RAL+GL  L L +N+   +P      +P LR   L +N L                
Sbjct: 174 EGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL---------------- 217

Query: 263 LHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLT 322
                                              CDCH+A +  WL++   +    +  
Sbjct: 218 ----------------------------------FCDCHLAWLSQWLRQRPTIGLFTQ-- 241

Query: 323 CAYPEKMRNRVLLELNSADLDC 344
           C+ P  +R   + E+  ++  C
Sbjct: 242 CSGPASLRGLNVAEVQKSEFSC 263


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 89/300 (29%), Positives = 121/300 (40%), Gaps = 28/300 (9%)

Query: 63  PALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAA 122
           PA     ++  TV      L E P +LP  VR L L  N +  +   A A+   L EL  
Sbjct: 81  PAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHL 140

Query: 123 LNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL-- 180
            + S S +  V  GAF    SL+ L LS N L          S+  V  P  L EL +  
Sbjct: 141 DDNSISTVG-VEDGAFREAISLKLLFLSKNHL----------SSVPVGLPVDLQELRVDE 189

Query: 181 NHIVPPEDER-QN-RSFEGMVV-AALLAGRA--------LQGLRRLELASNHFLYLPRDV 229
           N I    D   QN  S E ++V   LL  +         L  L+   +  N   + P D+
Sbjct: 190 NRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDL 249

Query: 230 LAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRV 289
                 L  L L +N +  +   +F NL  LE L + +N L++L  G    L  L  +  
Sbjct: 250 PG--THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTA 307

Query: 290 FLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILP 349
              NNPW CDC +  +  WLK            C  PE++R   + ELN   L C    P
Sbjct: 308 --RNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTP 365


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 95/344 (27%), Positives = 128/344 (37%), Gaps = 88/344 (25%)

Query: 62  CPALCECSEAAR--TVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAE 119
           CPA C CS   R  +V+C    L  VP +LP    ++ L  N L  L   AF   P L  
Sbjct: 31  CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRR 90

Query: 120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN---------PLADLSPFA--------- 161
           L+   L  + L  +  GAF+ LP L +L L+HN           A LS            
Sbjct: 91  LS---LRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147

Query: 162 FSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGR-------ALQGLRR 214
           FS     ++    L EL     +        R    +  A L  GR       +LQGLRR
Sbjct: 148 FSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRR 207

Query: 215 LE---------------------------LASNHFLYLPRDVLAQLPSLRHLDLSNNSLV 247
           L                            L  N    LP D    L  LR L+L  N+L 
Sbjct: 208 LRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALD 267

Query: 248 SLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHI-------------------- 287
            +    F +L  LE L+L+ N++  +  G    L GL  +                    
Sbjct: 268 RVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFF 327

Query: 288 --RVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLT---CAYP 326
             R+FL  NPW CDC +     WL++   ++G  R+T   CA P
Sbjct: 328 LGRLFLFRNPWCCDCRL----EWLRDW--MEGSGRVTDVPCASP 365


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 72/230 (31%), Positives = 105/230 (45%), Gaps = 23/230 (10%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CPA+C+C+   + V C +R L  VP  LP     L L+GN+L  L  G  +R   L+ L 
Sbjct: 31  CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSR---LSLLQ 87

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181
            L+LS ++L  +  GAF  L SL  L L  N L  + P  FSG +A       L++L LN
Sbjct: 88  ELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT-----LLDLRLN 142

Query: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241
            IV   D                A   L  L++LE+  NH +++     A L  L  L L
Sbjct: 143 QIVLFLDG---------------AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTL 187

Query: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFL 291
              +L ++  ++   L  L +L L +  +  L  G L  L  L  + + L
Sbjct: 188 ERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHL 237



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 6/93 (6%)

Query: 81  NLTEVPTDLP---AYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGA 137
           NL+ VP       +++R L L+ N ++ +PA    R  PL  L  L LSG+ L  + A A
Sbjct: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPA---RRLSPLVRLQELRLSGACLTSIAAHA 319

Query: 138 FEHLPSLRQLDLSHNPLADLSPFAFSGSNASVS 170
           F  L +   LD++ N L  L   AF   +  V+
Sbjct: 320 FHGLTAFHLLDVADNALQTLEETAFPSPDKLVT 352



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 72/295 (24%), Positives = 95/295 (32%), Gaps = 105/295 (35%)

Query: 81  NLTEVP----TDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL---------------- 120
           NL+ VP      LPA V  L L    +  LPAGA      L EL                
Sbjct: 191 NLSTVPGLALARLPALVA-LRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSL 249

Query: 121 AALNLSG-----SRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPL 175
             LNLS        L  V   A  HL  LR LDLS NP+          S       SPL
Sbjct: 250 VGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPI----------SAIPARRLSPL 299

Query: 176 VELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPS 235
           V L            Q     G  + + +A  A  GL    L                  
Sbjct: 300 VRL------------QELRLSGACLTS-IAAHAFHGLTAFHL------------------ 328

Query: 236 LRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNP 295
              LD+++N+L +L   +F +   L +L                           L  NP
Sbjct: 329 ---LDVADNALQTLEETAFPSPDKLVTLR--------------------------LSGNP 359

Query: 296 WVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPP 350
             CDC +  ++   +  +   G     CA P  ++ + L E +        ILPP
Sbjct: 360 LTCDCRLLWLLRLRRHLDF--GMSPPACAGPHHVQGKSLKEFSD-------ILPP 405


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 73/287 (25%), Positives = 110/287 (38%), Gaps = 55/287 (19%)

Query: 59  PDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLA 118
           P  CPA C CS    TV C    L  VP ++P     L L GN +  +    FA    L 
Sbjct: 25  PQACPAQCSCS--GSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFA---GLR 79

Query: 119 ELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVEL 178
            L  L L  +++  +  GAF+ L  L +L L+ N L       F G+             
Sbjct: 80  HLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGT------------- 126

Query: 179 ILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRH 238
                                            L RL+L+ N    +PR        +++
Sbjct: 127 -------------------------------AKLYRLDLSENQIQAIPRKAFRGAVDIKN 155

Query: 239 LDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVF-LDNNPWV 297
           L L  N +  +   +FR L  LE L L +N +  L   ++A    +P +R F L +N   
Sbjct: 156 LQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRL---SVASFNHMPKLRTFRLHSNNLY 212

Query: 298 CDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
           CDCH+A +  WL++   V    +  C  P  +R   + E+   +  C
Sbjct: 213 CDCHLAWLSDWLRQRPRVGLYTQ--CMGPSHLRGHNVAEVQKREFVC 257



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 68/283 (24%), Positives = 109/283 (38%), Gaps = 77/283 (27%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CPA C CS     V C  + LTE+PT+LP  +  + L  N + V+P GAF+   P  +L 
Sbjct: 273 CPAACTCSN--NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFS---PYKKLR 327

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181
            ++LS +++ E+   AF+ L SL  L L  N + +L    F G                 
Sbjct: 328 RIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEG----------------- 370

Query: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241
                                      L  L+ L L +N    L  D    L +L  L L
Sbjct: 371 ---------------------------LFSLQLLLLNANKINCLRVDAFQDLHNLNLLSL 403

Query: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCH 301
            +N L ++   +F  L  ++++HL                            NP++CDCH
Sbjct: 404 YDNKLQTIAKGTFSPLRAIQTMHLA--------------------------QNPFICDCH 437

Query: 302 MADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDC 344
           +  +  +L    +     R  C  P ++ N+ + ++ S    C
Sbjct: 438 LKWLADYLHTNPIETSGAR--CTSPRRLANKRIGQIKSKKFRC 478



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 72/286 (25%), Positives = 117/286 (40%), Gaps = 80/286 (27%)

Query: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121
           CP  C C     TV C N+ L ++P  +P Y   L L  N+  VL A             
Sbjct: 506 CPEKCRCE--GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEA------------- 550

Query: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL- 180
                         G F+ LP LR+++ S+N + D+   AF G+       S + E++L 
Sbjct: 551 -------------TGIFKKLPQLRKINFSNNKITDIEEGAFEGA-------SGVNEILLT 590

Query: 181 -NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHL 239
            N +    +  Q++ F+G           L+ L+ L L SN    +  D    L S+R L
Sbjct: 591 SNRL----ENVQHKMFKG-----------LESLKTLMLRSNRITCVGNDSFIGLSSVRLL 635

Query: 240 DLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCD 299
            L +N + ++   +F  L  L +L+L            LA              NP+ C+
Sbjct: 636 SLYDNQITTVAPGAFDTLHSLSTLNL------------LA--------------NPFNCN 669

Query: 300 CHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCD 345
           C++A +  WL++  +V G  R  C  P  ++   + ++   D  CD
Sbjct: 670 CYLAWLGEWLRKKRIVTGNPR--CQKPYFLKEIPIQDVAIQDFTCD 713



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 76/308 (24%), Positives = 122/308 (39%), Gaps = 64/308 (20%)

Query: 93  VRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN 152
           ++ L L  N++  +   +F     L+ +  L+L  +++  V  GAF+ L SL  L+L  N
Sbjct: 608 LKTLMLRSNRITCVGNDSFIG---LSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664

Query: 153 PLADLSPFAFSGS----------NASVSAPSPLVELILNHIVPPE----DERQNRSFEGM 198
           P       A+ G           N     P  L E+ +  +   +    D   + S   +
Sbjct: 665 PFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPL 724

Query: 199 ------------VVAALLAGRAL--QGLRR----LELASNHFLYLPRDVLAQLPSLRHLD 240
                       VV     G  +  +G+ R    L L  N F  +P++ L+    L  +D
Sbjct: 725 SRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLID 783

Query: 241 LSNNSLVSLTYVSFRNLTHLESLHLEDNALK------------------------VLHNG 276
           LSNN + +L+  SF N+T L +L L  N L+                        V+  G
Sbjct: 784 LSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEG 843

Query: 277 TLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLE 336
              +L  L H+ +    NP  CDC+M  +  W+K      G  R  CA P +M +++LL 
Sbjct: 844 AFNDLSALSHLAI--GANPLYCDCNMQWLSDWVKSEYKEPGIAR--CAGPGEMADKLLLT 899

Query: 337 LNSADLDC 344
             S    C
Sbjct: 900 TPSKKFTC 907



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 6/104 (5%)

Query: 61  QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL 120
           +CP  C C +    V+C N+ L  +P  +P  V  L+L GNQ  ++P            L
Sbjct: 726 RCPTECTCLDTV--VRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP----KELSNYKHL 779

Query: 121 AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSG 164
             ++LS +R+  +   +F ++  L  L LS+N L  + P  F G
Sbjct: 780 TLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDG 823


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,369,701
Number of Sequences: 37866
Number of extensions: 722709
Number of successful extensions: 5038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2992
Number of HSP's gapped (non-prelim): 1020
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.