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Search of human proteins with 56676397
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
(2663 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 5359 0.0
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 536 e-151
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 523 e-147
gi|148746195 trichohyalin [Homo sapiens] 155 7e-37
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 132 6e-30
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 132 6e-30
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 132 6e-30
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 125 4e-28
gi|87299628 biorientation of chromosomes in cell division 1-like... 124 2e-27
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 122 6e-27
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 117 1e-25
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 116 3e-25
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 116 3e-25
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 111 8e-24
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 111 8e-24
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 110 1e-23
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 103 2e-21
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 102 5e-21
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 102 7e-21
gi|188219549 ankyrin repeat domain 32 [Homo sapiens] 101 9e-21
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 99 4e-20
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 98 9e-20
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 98 9e-20
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 97 2e-19
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 97 2e-19
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens] 97 2e-19
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens] 97 2e-19
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens] 97 2e-19
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens] 97 2e-19
gi|163965366 nascent polypeptide-associated complex alpha subuni... 96 5e-19
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 5359 bits (13902), Expect = 0.0
Identities = 2663/2663 (100%), Positives = 2663/2663 (100%)
Query: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKL 60
MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKL
Sbjct: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKL 60
Query: 61 PFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALL 120
PFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALL
Sbjct: 61 PFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALL 120
Query: 121 MQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGD 180
MQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGD
Sbjct: 121 MQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGD 180
Query: 181 ARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHD 240
ARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHD
Sbjct: 181 ARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHD 240
Query: 241 AANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESS 300
AANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESS
Sbjct: 241 AANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESS 300
Query: 301 EEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPP 360
EEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPP
Sbjct: 301 EEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPP 360
Query: 361 VDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTV 420
VDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTV
Sbjct: 361 VDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTV 420
Query: 421 GTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSE 480
GTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSE
Sbjct: 421 GTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSE 480
Query: 481 SESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTD 540
SESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTD
Sbjct: 481 SESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTD 540
Query: 541 QHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRK 600
QHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRK
Sbjct: 541 QHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRK 600
Query: 601 RASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYE 660
RASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYE
Sbjct: 601 RASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYE 660
Query: 661 YEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKR 720
YEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKR
Sbjct: 661 YEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKR 720
Query: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN 780
IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN
Sbjct: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN 780
Query: 781 DLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR 840
DLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR
Sbjct: 781 DLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR 840
Query: 841 WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900
WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY
Sbjct: 841 WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900
Query: 901 REPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKE 960
REPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKE
Sbjct: 901 REPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKE 960
Query: 961 RRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERK 1020
RRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERK
Sbjct: 961 RRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERK 1020
Query: 1021 EKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASL 1080
EKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASL
Sbjct: 1021 EKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASL 1080
Query: 1081 DQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEA 1140
DQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEA
Sbjct: 1081 DQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEA 1140
Query: 1141 SDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEK 1200
SDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEK
Sbjct: 1141 SDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEK 1200
Query: 1201 VFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS 1260
VFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS
Sbjct: 1201 VFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS 1260
Query: 1261 DKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAF 1320
DKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAF
Sbjct: 1261 DKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAF 1320
Query: 1321 LEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDY 1380
LEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDY
Sbjct: 1321 LEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDY 1380
Query: 1381 KEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKK 1440
KEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKK
Sbjct: 1381 KEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKK 1440
Query: 1441 IEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQ 1500
IEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQ
Sbjct: 1441 IEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQ 1500
Query: 1501 KPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKD 1560
KPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKD
Sbjct: 1501 KPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKD 1560
Query: 1561 PGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKL 1620
PGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKL
Sbjct: 1561 PGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKL 1620
Query: 1621 KEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWL 1680
KEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWL
Sbjct: 1621 KEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWL 1680
Query: 1681 AGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYADLVFDCA 1740
AGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYADLVFDCA
Sbjct: 1681 AGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYADLVFDCA 1740
Query: 1741 DSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPE 1800
DSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPE
Sbjct: 1741 DSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPE 1800
Query: 1801 EEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEKFACLSPGYYSPDYGLPSP 1860
EEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEKFACLSPGYYSPDYGLPSP
Sbjct: 1801 EEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEKFACLSPGYYSPDYGLPSP 1860
Query: 1861 KVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQAT 1920
KVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQAT
Sbjct: 1861 KVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQAT 1920
Query: 1921 AAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLL 1980
AAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLL
Sbjct: 1921 AAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLL 1980
Query: 1981 LKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDG 2040
LKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDG
Sbjct: 1981 LKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDG 2040
Query: 2041 VDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLEN 2100
VDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLEN
Sbjct: 2041 VDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLEN 2100
Query: 2101 SFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESL 2160
SFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESL
Sbjct: 2101 SFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESL 2160
Query: 2161 APPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAA 2220
APPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAA
Sbjct: 2161 APPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAA 2220
Query: 2221 VEAETVPEERARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVA 2280
VEAETVPEERARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVA
Sbjct: 2221 VEAETVPEERARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVA 2280
Query: 2281 QAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNR 2340
QAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNR
Sbjct: 2281 QAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNR 2340
Query: 2341 AQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQL 2400
AQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQL
Sbjct: 2341 AQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSEDDDAQAQHPRKRRFQRSTQQLQQQL 2400
Query: 2401 NTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRKKIEEKRKILCCITP 2460
NTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRKKIEEKRKILCCITP
Sbjct: 2401 NTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRKKIEEKRKILCCITP 2460
Query: 2461 QAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGKLRLQHS 2520
QAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGKLRLQHS
Sbjct: 2461 QAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGKLRLQHS 2520
Query: 2521 IEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRD 2580
IEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRD
Sbjct: 2521 IEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRD 2580
Query: 2581 RFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLC 2640
RFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLC
Sbjct: 2581 RFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLC 2640
Query: 2641 VNEVPSFYVPMVDVNDDFVLLPA 2663
VNEVPSFYVPMVDVNDDFVLLPA
Sbjct: 2641 VNEVPSFYVPMVDVNDDFVLLPA 2663
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 536 bits (1380), Expect = e-151
Identities = 466/1414 (32%), Positives = 697/1414 (49%), Gaps = 202/1414 (14%)
Query: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKV-SLTKTPKLERGDGGKEVRERAS-KR 58
MPK G K Q E S+MVEK G+K KDK+ S +KTPK+ER D KE++E++S KR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 59 KLPFTAG-ANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQV 117
KLPFT + E++DSDTEK+GPE+K+ KKE +K+ + I GYPLSER+Q+
Sbjct: 61 KLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPV------SILFGYPLSERKQM 114
Query: 118 ALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAI 177
ALLMQMTA + NSP D+TP HPSQ+T QK TP+S+S+ KDKVNKRNERGET LH AAI
Sbjct: 115 ALLMQMTARD--NSP-DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAI 171
Query: 178 RGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTP 237
RGD +++KELIS GA+VNVKDFAGWT LHEACN GYYDVAK L+AAGA+VNT+GLDDDTP
Sbjct: 172 RGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 231
Query: 238 LHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESST 297
LHD+A++GH +VKLLLR+GGNP Q+N+ GE P+ VA + + LL + + +ES T
Sbjct: 232 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYT 291
Query: 298 ESSEEEDAPSFAPSSSVDGNNTDSEFEK-GLKHKAKNPEPQKATAP-VKDEYEFDEDDEQ 355
+S E+A S P SSVD N DSE EK L ++K P K P DEYEF +DD++
Sbjct: 292 DS---EEAQSVNP-SSVD-ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDE 346
Query: 356 DRVPPVDDKHLLKKDYRKETKSNSFIS--IPKMEVKSYTKNNTIAPKKASHRILSDTSDE 413
+ +DD+H+L+K+ RKE + + + K E Y K+ +K S + S T
Sbjct: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 406
Query: 414 EDASVTVGTGEKLRLSAHTILPGSKTREPSNAK------QQKEKNKVKKKRKKETKGREV 467
++ ++ +K+ S +++P + + K + K+K KVK+K K + K +E
Sbjct: 407 DEEAL---QNKKISTSC-SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN 462
Query: 468 RFGKRSDKFC-SSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSL-FSSLSASSTSS 525
+ K+ + ++ + + +G D + G + S D SL +S +
Sbjct: 463 QELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK 522
Query: 526 HGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSS 585
H ++KQ+ +HT KT SP SE+S D R T ES++ E SS
Sbjct: 523 HSCGLSEKQSTPLKQEHT--------KTCLSPGSSEMSLQPDLVRYDNT-ESEFLPESSS 573
Query: 586 VESLKPVRKRQEHRKRASL-----------SEKKSPFLSSAEGAVPKLDKEGKVVKKHKT 634
V+S K +++ +H+K L E SP +++ + K+DKEGK +KKHK
Sbjct: 574 VKSCKH-KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKL 632
Query: 635 KHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHF 694
KHK + KEK + +E++ + Y+ +DS ++ +++ + + EN K D F
Sbjct: 633 KHKEREKEKHK----KEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFK-SDETEDLF 687
Query: 695 KKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPK 754
E S + LE+K L K+ K K K+ + R+F+EE+D+ K EKS +
Sbjct: 688 LNMEHES-LTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKE------SEKSFR 740
Query: 755 EEKLRLYKEERKKKSKDRPSKLEKKN----------DLKEDKISKEK-EKIFKEDKEKLK 803
EEK++ KEER+ D+ S+ L E +I EK EK KE KEK +
Sbjct: 741 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 800
Query: 804 KEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVT 863
K +E E + F + + K ++D+ DLS+ K +D S T
Sbjct: 801 KRSQIKEKDI--EKMERKTFEKEKKIKHE-HKSEKDK--LDLSECVDKIKEKDKLYSHHT 855
Query: 864 DYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQ 923
+ + KE E+ +++ A +K D RE K R+ +D+ +K K +
Sbjct: 856 E--------------KCHKEG--EKSKNTAAIKKTDDRE-----KSREKMDRKHDKEKPE 894
Query: 924 TEKH--KSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGC 981
E+H +S +L EK K+ +++E + K K +E RE
Sbjct: 895 KERHLAESKEKHLMEKKNKQSDNSEYSKSEK-------------GKNKEKDRE------- 934
Query: 982 ESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKS 1041
DK + K +E++K D + + KP KEK+ D+
Sbjct: 935 ----LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 990
Query: 1042 ILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSE 1101
EK +KDK+ D+ +KE ++KH KDK + SL + K + +K P S
Sbjct: 991 GKEKDKKDKDIDR-YKE----RDKH-----KDKIQINSLLKLKSEADKPKP-----KSSP 1035
Query: 1102 KKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYAS 1161
D + KEK D+ E +M DL E E+
Sbjct: 1036 ASKDTRPKEKRLVNDDLMQTSFE-----------RMLSLKDL-------EIEQW------ 1071
Query: 1162 DRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK 1221
H+K H E+ K KE ++R ++R + KEK E K+KE T + +
Sbjct: 1072 --HKK-----HKEKIKQKE-KERLRNRNCLELKIKDKEKTKHTPTESKNKELT---RSKS 1120
Query: 1222 DRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKE-----HSKERKSSRSADA 1276
+ T++K+ K + +++ K SD S+ K S+ +
Sbjct: 1121 SEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRS 1180
Query: 1277 EKSLLEKLEEEALH----------EYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFT 1326
+ E++ H EY D SS+S Q P FL ++ +
Sbjct: 1181 VSMISVASSEDSCHTTVTTPRPPVEYDSD----FMLESSESQMSFSQSP----FLSIAKS 1232
Query: 1327 EPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
+ + A LPE++K +R S+S + S
Sbjct: 1233 PALHERELDSLADLPERIKPPYANRLSTSHLRSS 1266
Score = 452 bits (1162), Expect = e-126
Identities = 231/337 (68%), Positives = 275/337 (81%), Gaps = 10/337 (2%)
Query: 2331 EIPQRMTRNRAQMLANQSKQGPPP----SEKECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386
+IPQRMTRN+A +ANQSKQ SEK+ + + R + R +EDDD Q HPRK
Sbjct: 1707 QIPQRMTRNKANTMANQSKQILASCTLLSEKD---SESSSPRGRIRLTEDDDPQIHHPRK 1763
Query: 2387 RRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRK 2446
R+ R Q +Q ++ S Q +E QQ+LAAIVD++KLD I+PY S+RANPYFEYL IRK
Sbjct: 1764 RKVSRVPQPVQ--VSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRK 1821
Query: 2447 KIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFR 2506
KIEEKRK+LC + PQAPQ Y EYVT+ GSYLLDG PLSK+ IP I PPPSL++PLKELFR
Sbjct: 1822 KIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFR 1881
Query: 2507 QQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNM 2566
QQE VR KLRLQHSIEREKLIVS EQE+LRVH RAART+ANQ +PFSACT+LLD+EVYN+
Sbjct: 1882 QQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNV 1941
Query: 2567 PLESQGDENK-SVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQ 2625
PL+SQ D++K SVRDRFNARQF+SWLQDVDDK+D++KTCLLMRQQHEAAALNAVQR+EWQ
Sbjct: 1942 PLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQ 2001
Query: 2626 LKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLP 2662
LK+QELDPA +KS+ + E+ FYVP+VDVNDDF L P
Sbjct: 2002 LKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTP 2038
Score = 181 bits (460), Expect = 7e-45
Identities = 258/1123 (22%), Positives = 454/1123 (40%), Gaps = 184/1123 (16%)
Query: 737 DRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK 796
D + E E LK + P + Y + + +S + PS +++ D + EK+ +
Sbjct: 266 DVAETEELELLLKREVPLSDDDESYTDSEEAQSVN-PSSVDENIDSET-----EKDSLIC 319
Query: 797 EDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFS--------LSDDQRDRWFSDLSDS 848
E K+ L + SA DEY +F +++D + + L +QR + +
Sbjct: 320 ESKQILPSKTPL--PSALDEY----EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 373
Query: 849 SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908
K E ++ + K V E+ E++ + ++ S +
Sbjct: 374 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS------------ 421
Query: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968
+ + QT+K V G +K K +R+ +++++ + K+ ++G+
Sbjct: 422 ----VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN--QELKQEKEGKENT 475
Query: 969 EEAHREELKECGCESGFKDKSDGDFGKGLEPWER-----HHPAREKEKKDGPDKERKEKT 1023
+ G + K + +G+F K P + H + K K K+ T
Sbjct: 476 RITNLTV--NTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 533
Query: 1024 KPERYKEKS-----SDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK- 1077
++ K+ S + + ++ + EF K K K K H KD +
Sbjct: 534 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 593
Query: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKM 1137
K K E P + D + KK DK+GK + E E + G K
Sbjct: 594 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 653
Query: 1138 ---GEASDLPRT---------DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRR 1185
A +L R+ + + +E + + + H + ++ + +K+ +
Sbjct: 654 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 713
Query: 1186 KDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK------DRASVDSTQDKKNKQKLP 1239
K++ + KE+ F++ ++K KES + +++ K +R ++ + +D +
Sbjct: 714 KEKHVS------KERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGM 767
Query: 1240 EKAEKK---HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296
E+ H E + + +EK KE SKE+ RS EK + EK+E + + ++
Sbjct: 768 SAIEESIGLHLVEKEIDIEKQEKHIKE-SKEKPEKRSQIKEKDI-EKMERKTFEKEKKIK 825
Query: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356
++ SE DK S C+ +K+KEK++ +S +
Sbjct: 826 HEHKSE----------------------------KDKLDLSECV-DKIKEKDK-LYSHHT 855
Query: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
K + E++K A KK D +E K +++K+ K + E L
Sbjct: 856 EKCHKEGEKSKNTAAIKKT---DDREKSREKMDRKHDKE-------------KPEKERHL 899
Query: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERH 1476
++ E EKK+K E SK ++ K +EK RE D+KE+
Sbjct: 900 AESKEKHLMEKKNKQSDNSEYSKS----------------EKGKNKEKDREL--DKKEKS 941
Query: 1477 RDRHADGLLRHHRDELLRHHRDEQKPATRD----KDSPPRVLKDKSRDEGPRLGDAKLKE 1532
RD+ + + +H ++E+K + D + P LK+K++DE + D K K+
Sbjct: 942 RDKESINITNS------KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
Query: 1533 KFKDGAEKEK-----------GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMT 1581
K ++ K +K+ + DK P P KD RP+EK L + DLM T
Sbjct: 996 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1055
Query: 1582 SFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD-----PKLKEKAKPADDGRKKGLD 1636
SFERMLS KDLEIE+ HK+HKE++KQ EK R R+ + K KEK K K
Sbjct: 1056 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1115
Query: 1637 IPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEV----LPAS 1692
+K D K+K+ K+ A N+ + D+K+ + V L S
Sbjct: 1116 TRSKSSEVTDAYTKEKQPKD------AVSNR---SQSVDTKNVMTLGKSSFVSDNSLNRS 1166
Query: 1693 PRPDQSRPTGVPTPTSVLSCPSYEEVMHTP-RTPSCSADDYADLVFDCADSQHSTPVPTA 1751
PR + +P S++S S E+ HT TP + +D + + ++SQ S
Sbjct: 1167 PRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPF 1226
Query: 1752 PTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVD 1794
+ A SP+ +R + + L E A LST+ RS SV+
Sbjct: 1227 LSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVE 1269
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 523 bits (1346), Expect = e-147
Identities = 466/1437 (32%), Positives = 697/1437 (48%), Gaps = 225/1437 (15%)
Query: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKV-SLTKTPKLERGDGGKEVRERAS-KR 58
MPK G K Q E S+MVEK G+K KDK+ S +KTPK+ER D KE++E++S KR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 59 KLPFTAG-ANGEQKDSDT-----------------------EKQGPERKRIKKEPVTRKA 94
KLPFT + E++DSDT EK+GPE+K+ KKE +K+
Sbjct: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
Query: 95 GLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSA 154
+ I GYPLSER+Q+ALLMQMTA + NSP D+TP HPSQ+T QK TP+S+
Sbjct: 121 TPV------SILFGYPLSERKQMALLMQMTARD--NSP-DSTPNHPSQTTPAQKKTPSSS 171
Query: 155 SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214
S+ KDKVNKRNERGET LH AAIRGD +++KELIS GA+VNVKDFAGWT LHEACN GYY
Sbjct: 172 SRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYY 231
Query: 215 DVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA 274
DVAK L+AAGA+VNT+GLDDDTPLHD+A++GH +VKLLLR+GGNP Q+N+ GE P+ VA
Sbjct: 232 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Query: 275 NSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEK-GLKHKAKN 333
+ + LL + + +ES T+S E+A S P SSVD N DSE EK L ++K
Sbjct: 292 ETEELELLLKREVPLSDDDESYTDS---EEAQSVNP-SSVD-ENIDSETEKDSLICESKQ 346
Query: 334 PEPQKATAP-VKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFIS--IPKMEVKS 390
P K P DEYEF +DD+++ +DD+H+L+K+ RKE + + + K E
Sbjct: 347 ILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK---- 446
Y K+ +K S + S T ++ ++ +K+ S +++P + + K
Sbjct: 407 YPKSFKSKKQKPSRVLYSSTESSDEEAL---QNKKISTSC-SVIPETSNSDMQTKKEYVV 462
Query: 447 --QQKEKNKVKKKRKKETKGREVRFGKRSDKFC-SSESESESSESGEDDRDSLGSSGCLK 503
+ K+K KVK+K K + K +E + K+ + ++ + + +G D + G +
Sbjct: 463 SGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 522
Query: 504 GSPLVLKDPSL-FSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEV 562
S D SL +S + H ++KQ+ +HT KT SP SE+
Sbjct: 523 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT--------KTCLSPGSSEM 574
Query: 563 SSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASL-----------SEKKSPF 611
S D R T ES++ E SSV+S K +++ +H+K L E SP
Sbjct: 575 SLQPDLVRYDNT-ESEFLPESSSVKSCKH-KEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
Query: 612 LSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKA 671
+++ + K+DKEGK +KKHK KHK + KEK + +E++ + Y+ +DS ++ ++
Sbjct: 633 FENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHK----KEIEGEKEKYKTKDSAKELQRS 688
Query: 672 ILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRS 731
+ + + EN K D F E S + LE+K L K+ K K K+ + R+
Sbjct: 689 VEFDREFWKENFFK-SDETEDLFLNMEHES-LTLEKKSKLEKNIKDDKSTKEKHVSKERN 746
Query: 732 FREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN----------D 781
F+EE+D+ K EKS +EEK++ KEER+ D+ S+
Sbjct: 747 FKEERDKIKKE------SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 800
Query: 782 LKEDKISKEK-EKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR 840
L E +I EK EK KE KEK +K +E E + F + + K ++D+
Sbjct: 801 LVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHE-HKSEKDK 857
Query: 841 WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900
DLS+ K +D S T+ + KE E+ +++ A +K D
Sbjct: 858 --LDLSECVDKIKEKDKLYSHHTE--------------KCHKEG--EKSKNTAAIKKTDD 899
Query: 901 REPFFRKKDRDYLDKNSEKRKEQTEKH--KSVPGYLSEKDKKRRESAEAGRDRKDALESC 958
RE K R+ +D+ +K K + E+H +S +L EK K+ +++E + K
Sbjct: 900 RE-----KSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK------ 948
Query: 959 KERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKE 1018
K +E RE DK + K +E++K D
Sbjct: 949 -------GKNKEKDRE-----------LDKKEKSRDKESINITNSKHIQEEKKSSIVDGN 990
Query: 1019 RKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKA 1078
+ + KP KEK+ D+ EK +KDK+ D+ +KE ++KH KDK +
Sbjct: 991 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDR-YKE----RDKH-----KDKIQIN 1040
Query: 1079 SLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138
SL + K + +K P S D + KEK D+ E +M
Sbjct: 1041 SLLKLKSEADKPKP-----KSSPASKDTRPKEKRLVNDDLMQTSFE-----------RML 1084
Query: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
DL E E+ H+K H E+ K KE ++R ++R + K
Sbjct: 1085 SLKDL-------EIEQW--------HKK-----HKEKIKQKE-KERLRNRNCLELKIKDK 1123
Query: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
EK E K+KE T + + + T++K+ K + +++ K
Sbjct: 1124 EKTKHTPTESKNKELT---RSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSF 1180
Query: 1259 KSDKE-----HSKERKSSRSADAEKSLLEKLEEEALH----------EYREDSNDKISEV 1303
SD S+ K S+ + + E++ H EY D
Sbjct: 1181 VSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSD----FMLE 1236
Query: 1304 SSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
SS+S Q P FL ++ + + + A LPE++K +R S+S + S
Sbjct: 1237 SSESQMSFSQSP----FLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSS 1289
Score = 452 bits (1162), Expect = e-126
Identities = 231/337 (68%), Positives = 275/337 (81%), Gaps = 10/337 (2%)
Query: 2331 EIPQRMTRNRAQMLANQSKQGPPP----SEKECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386
+IPQRMTRN+A +ANQSKQ SEK+ + + R + R +EDDD Q HPRK
Sbjct: 1730 QIPQRMTRNKANTMANQSKQILASCTLLSEKD---SESSSPRGRIRLTEDDDPQIHHPRK 1786
Query: 2387 RRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRK 2446
R+ R Q +Q ++ S Q +E QQ+LAAIVD++KLD I+PY S+RANPYFEYL IRK
Sbjct: 1787 RKVSRVPQPVQ--VSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRK 1844
Query: 2447 KIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFR 2506
KIEEKRK+LC + PQAPQ Y EYVT+ GSYLLDG PLSK+ IP I PPPSL++PLKELFR
Sbjct: 1845 KIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFR 1904
Query: 2507 QQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNM 2566
QQE VR KLRLQHSIEREKLIVS EQE+LRVH RAART+ANQ +PFSACT+LLD+EVYN+
Sbjct: 1905 QQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNV 1964
Query: 2567 PLESQGDENK-SVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQ 2625
PL+SQ D++K SVRDRFNARQF+SWLQDVDDK+D++KTCLLMRQQHEAAALNAVQR+EWQ
Sbjct: 1965 PLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQ 2024
Query: 2626 LKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLP 2662
LK+QELDPA +KS+ + E+ FYVP+VDVNDDF L P
Sbjct: 2025 LKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTP 2061
Score = 181 bits (460), Expect = 7e-45
Identities = 258/1123 (22%), Positives = 454/1123 (40%), Gaps = 184/1123 (16%)
Query: 737 DRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK 796
D + E E LK + P + Y + + +S + PS +++ D + EK+ +
Sbjct: 289 DVAETEELELLLKREVPLSDDDESYTDSEEAQSVN-PSSVDENIDSET-----EKDSLIC 342
Query: 797 EDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFS--------LSDDQRDRWFSDLSDS 848
E K+ L + SA DEY +F +++D + + L +QR + +
Sbjct: 343 ESKQILPSKTPL--PSALDEY----EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 396
Query: 849 SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908
K E ++ + K V E+ E++ + ++ S +
Sbjct: 397 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS------------ 444
Query: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968
+ + QT+K V G +K K +R+ +++++ + K+ ++G+
Sbjct: 445 ----VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN--QELKQEKEGKENT 498
Query: 969 EEAHREELKECGCESGFKDKSDGDFGKGLEPWER-----HHPAREKEKKDGPDKERKEKT 1023
+ G + K + +G+F K P + H + K K K+ T
Sbjct: 499 RITNLTV--NTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 556
Query: 1024 KPERYKEKS-----SDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK- 1077
++ K+ S + + ++ + EF K K K K H KD +
Sbjct: 557 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 616
Query: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKM 1137
K K E P + D + KK DK+GK + E E + G K
Sbjct: 617 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 676
Query: 1138 ---GEASDLPRT---------DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRR 1185
A +L R+ + + +E + + + H + ++ + +K+ +
Sbjct: 677 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
Query: 1186 KDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK------DRASVDSTQDKKNKQKLP 1239
K++ + KE+ F++ ++K KES + +++ K +R ++ + +D +
Sbjct: 737 KEKHVS------KERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGM 790
Query: 1240 EKAEKK---HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296
E+ H E + + +EK KE SKE+ RS EK + EK+E + + ++
Sbjct: 791 SAIEESIGLHLVEKEIDIEKQEKHIKE-SKEKPEKRSQIKEKDI-EKMERKTFEKEKKIK 848
Query: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356
++ SE DK S C+ +K+KEK++ +S +
Sbjct: 849 HEHKSE----------------------------KDKLDLSECV-DKIKEKDK-LYSHHT 878
Query: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
K + E++K A KK D +E K +++K+ K + E L
Sbjct: 879 EKCHKEGEKSKNTAAIKKT---DDREKSREKMDRKHDKE-------------KPEKERHL 922
Query: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERH 1476
++ E EKK+K E SK ++ K +EK RE D+KE+
Sbjct: 923 AESKEKHLMEKKNKQSDNSEYSKS----------------EKGKNKEKDREL--DKKEKS 964
Query: 1477 RDRHADGLLRHHRDELLRHHRDEQKPATRD----KDSPPRVLKDKSRDEGPRLGDAKLKE 1532
RD+ + + +H ++E+K + D + P LK+K++DE + D K K+
Sbjct: 965 RDKESINITNS------KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
Query: 1533 KFKDGAEKEK-----------GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMT 1581
K ++ K +K+ + DK P P KD RP+EK L + DLM T
Sbjct: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
Query: 1582 SFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD-----PKLKEKAKPADDGRKKGLD 1636
SFERMLS KDLEIE+ HK+HKE++KQ EK R R+ + K KEK K K
Sbjct: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1138
Query: 1637 IPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEV----LPAS 1692
+K D K+K+ K+ A N+ + D+K+ + V L S
Sbjct: 1139 TRSKSSEVTDAYTKEKQPKD------AVSNR---SQSVDTKNVMTLGKSSFVSDNSLNRS 1189
Query: 1693 PRPDQSRPTGVPTPTSVLSCPSYEEVMHTP-RTPSCSADDYADLVFDCADSQHSTPVPTA 1751
PR + +P S++S S E+ HT TP + +D + + ++SQ S
Sbjct: 1190 PRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPF 1249
Query: 1752 PTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVD 1794
+ A SP+ +R + + L E A LST+ RS SV+
Sbjct: 1250 LSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVE 1292
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 155 bits (391), Expect = 7e-37
Identities = 206/1130 (18%), Positives = 489/1130 (43%), Gaps = 151/1130 (13%)
Query: 593 RKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQEL 652
+KRQE + + E++S + + + D++ + + + + + + +E+ + Q
Sbjct: 139 QKRQEQERELAEGEEQS----EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 653 KLKSF-TYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWL 711
K T E+ D +Q + +L E K + + +D +EE EEKEW
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-------EEKEWR 247
Query: 712 FKD---EKSLKRIKDTNKDISRSFREEKDRSNKAEKE---RSLKEKSPKEEKLRLYKEER 765
++ K +++++ R +EE+++ K E++ R +E+ ++++LR ++ R
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 766 KKKSKDRPSKLEKKNDLKEDKISKE--KEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQF 823
+K+ ++R + E++ + +E + +E +E+ + ++E+ +++++ RE +
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 824 LENEDTKFSLSDDQRDRWFSDL-SDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVK 882
E E + L +Q+ R L + + + + + + ++ + + + +
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 883 EDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRR 942
E +ER +E+R+ R +++ RD+L KR+E+TE+H+ K + +R
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWL-----KREEETERHEQE----RRKQQLKR 478
Query: 943 ESAEAGRDRKDALESCKERRDG--------RAKPEEAHREELKECGCESGFKDKSDGDFG 994
+ E R+R LE +ERR+ R + EE + LK E + + +
Sbjct: 479 DQEEERRERWLKLEE-EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 995 KGLEPWERHHPAREKEKKDGPDKERKE---KTKPERYKEKSSDKDKSEKSILEKCQKDKE 1051
E ER ++E++ ++ER+E K + E +++ +++ + K ++++
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 1052 FDKCFK-------EKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKD 1104
++ K E+++ +E+ ++ER+ L + +E++E+ + E ++
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 1105 DKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEA-----SDLPRTD------------ 1147
K +E+ + E E++R + + +A S +P+
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 1148 -------------GLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRD----------- 1183
QE+EE R S+ + ++ H ++Q++++ RD
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 1184 --------------RRKDRGAADAGRDKKEKVF---EKHKEKKDKESTEKYKDRKDRASV 1226
+++R R ++E+ F E+ KE++ ++ E+ K+ +
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 1227 DSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDK---EHSKERKSSR-SADAEKSLLE 1282
+ Q ++ Q+L E+ + +++ +S+ + + K + +ERK R + A+ +L E
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 1283 KL--EEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACL 1340
+L E++ L E E E+ + R ++ + E + + RE
Sbjct: 898 QLRKEQQLLQEEEE-------ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER-- 948
Query: 1341 PEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEAD 1400
EK + +ER R K E+ E+ EK+ + E K+ ++ Q E+ L +
Sbjct: 949 -EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 1401 -------AYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAI 1453
+ Y K +++ E + +L E++ + ERE + E+EL+ +
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEE---QLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 1454 NILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRV 1513
+E ++R++ ++R E+E ++ + LLR ++ R R+ Q R+++ +
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEE--EQLLREEPEKRRRQERERQ---CREEEELQQE 1119
Query: 1514 LKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLL 1573
+ R+E + +L+ ++++ E ++ ++ ++P K+ + E+
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQ---------EEEQLLREEPEKRRRQELERQY 1170
Query: 1574 GDGDLMMTSFERMLSQKD----LEIEERHKRHKERMKQMEKLRHRSGDPK 1619
+ + + E++L ++ E E +++ +E +Q K R+R D +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Score = 155 bits (391), Expect = 7e-37
Identities = 233/1268 (18%), Positives = 534/1268 (42%), Gaps = 144/1268 (11%)
Query: 440 REPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSS 499
R+ ++Q+E+ + + KR++E + E R + E E E E++++
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKR------EHEEERREQELAEEEQEQARER 696
Query: 500 GCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAW 559
+K S + L S A + + Q+ +Q K R + S W
Sbjct: 697 --IK-SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE-----SELQW 748
Query: 560 SEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
E + + D++ + + E K R RQ R L E++ L + E
Sbjct: 749 QE-EERAHRQQQEEEQRRDFTWQWQAEE--KSERGRQRLSARPPLREQRERQLRAEE--- 802
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
+ +E + + + + K + + + + + Q L+ + E ++Q ++ L+ D
Sbjct: 803 -RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 680 TENKLKVLKHDRDHFKKEEKLSK------MKLEEKEWLFKDEKSLKRIKDTNKDISRSFR 733
+ + + ++ EE+ + K +E L K+++ L+ ++ + R
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ------R 915
Query: 734 EEKDRSNKAEKERSLKE----KSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISK 789
EE+++ + E+ER +E + +E+ LR +E+R+++ ++R + +KK KE+++
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 790 EKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSS 849
E+ E + + ++EK YRE+ + + Q L E K +R W
Sbjct: 976 EE----PEKRRRQEREKKYREEEELQQ--EEEQLLREEREK-----RRRQEW-------- 1016
Query: 850 FDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKD 909
YR K D + + + ++E+ ++RR R R+ R+ E ++++
Sbjct: 1017 ------------ERQYR--KKDELQQEEEQLLREEREKRRLQERERQYREEEE--LQQEE 1060
Query: 910 RDYL--DKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAK 967
L ++ + +R+E +++ E+++ RE E R R++ C+E + + +
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK-RRRQERERQCREEEELQQE 1119
Query: 968 PEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPER 1027
E+ REE ++ + + + E E+ ++ P+K R+++ + +
Sbjct: 1120 EEQLLREEREK---------RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE-RQ 1169
Query: 1028 YKEKSSDKDKSEKSILEKCQKDK-EFDKCFKEKKDTKEKHKDTHGKDKERKASLD-QGKE 1085
Y+E+ + + E+ + E+ +K + E ++ ++E+++ + + + +D+++++ L Q +
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 1086 KKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPR 1145
+KE A + K KG+E + D DR S +GE + R
Sbjct: 1230 EKENA--------VRDNKVYCKGRENEQFRQ--LEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Query: 1146 TDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKH 1205
++E R DRH ++ E QK+ + RDR+ +++EK +
Sbjct: 1280 ------EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 1206 KEKKDKESTEKYKDRKDRASVDSTQDKK-NKQKLPEKAEKKHAAEDKAKSKHKEKSDKEH 1264
++K +E + ++R+++ +D+K +++L + + + E++ + + +E+ +++
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER-ERKF 1392
Query: 1265 SKERKSSRSADAEKSLLE----KLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAF 1320
KE + R + E+ L + K EE R++ + K E R QE
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV---RRQERERKFL 1449
Query: 1321 LEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEK------- 1373
E K RE L ++ +E++ HR +++ ++E+ K
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 1374 -KEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKND 1432
+E + E + Q ++ FL+ + + D+ F E++ + +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK---FREEEQLRQE 1566
Query: 1433 SEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDEL 1492
E + + E++ K + ++K +R++ K+ +++++ R + LR RD
Sbjct: 1567 REEQQLSRQERDRK------FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 1493 LRHHRDEQKPATRDKDSPPRVLKD-KSRDEGPRLGDAKLKEKFK-DGAEKEKGDPVKMSN 1550
R DEQ R++ R +D K +E P+L + +++ + D K + + +
Sbjct: 1621 FR--EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 1551 GNDKVAPSKDPGKKDARPREKL-LGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQME 1609
G ++ ++ +K ++L + + E+ L +++LE + R + + + E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 1610 KLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLH 1669
+LR + K+ E+ + P ++ L +D+K +E + E +
Sbjct: 1739 QLRRQERYRKILEEEQLR----------PEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788
Query: 1670 PASGADSK 1677
+ +D K
Sbjct: 1789 RSQESDRK 1796
Score = 147 bits (372), Expect = 1e-34
Identities = 198/1129 (17%), Positives = 486/1129 (43%), Gaps = 123/1129 (10%)
Query: 570 RTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVV 629
R R + E E + R++QE R++ ++ E +L +E +
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 630 KKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLK---- 685
++ + + + +E+ + + +E +L+ + + + ++ + E L E +L+
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 686 ------------VLKHDRDH--FKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRS 731
+H++ H ++E++L + + E ++WL ++E++ + ++ K +
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 732 FREEKDRSN--KAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEK----------- 778
+EE+ R K E+E +++ +E++LR +EER+++ R + E+
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 779 ---KNDLKEDKISKEKEKIFKEDK--EKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSL 833
+ + +E + +E+EK ++++ ++LK+E+ R D E E + L
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR--------EEERRQQRL 590
Query: 834 SDDQRDRWFSDLSDSSFDFKGED-------SWDSPVTDYRD--MKSDSVAKLILETVKED 884
+Q +R L + ++ + P + R +KS+ + + ++ +
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 885 SKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKS-----VPGYL----S 935
+ERR RE+ + R K++ + + E +E+ E+ + +P + S
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 936 EKDKKR-----RESAEAGRDRKDALESCKERRDGR---AKPEEAHREEL-KECGCESGFK 986
E D ++ R + G+ R+ E + RR+ + E AHR++ +E + ++
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 987 DKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTK----PERYKEKSSDKDKSEKSI 1042
+++ +G + P RE+ ++ +ER+++ + E KE+ + + +
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Query: 1043 LEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEK 1102
L+ +++++ + +E+ ++ +D +D+ER+ S +Q +++K + +
Sbjct: 831 LQFLEEEEQLQR--RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR----------WQL 878
Query: 1103 KDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASD 1162
++++K + + Y ++ ++ E +L R +E+E+ R
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQ------LLQEEEEELQR----EEREKRRRQEQER 928
Query: 1163 RHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKD 1222
++R+ Q E Q +E R++R+ R ++E+ + K K+ + KE ++ +
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRR--------RQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 1223 RASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLE 1282
R + ++KK +++ + E++ ++ + + +++ ++++ K K + E+ L E
Sbjct: 981 RRRQE--REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK--KDELQQEEEQLLRE 1036
Query: 1283 KLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACL-- 1340
+ E+ L E RE + E+ + G+E E+ ++ +E L
Sbjct: 1037 EREKRRLQE-RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 1341 --PEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLE 1398
PEK + +ER R + + E+ +E+ EK+ + E ++ ++ Q E+ L
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 1399 AD---AYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINI 1455
+ + E+EL + E E+++K ERE + E+EL+
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ--RQKRKQR 1213
Query: 1456 LKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVL- 1514
+++ +R + +W EKE + R + +E R D Q + + +L
Sbjct: 1214 YRDEDQRSDLKWQWEPEKE-NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 1515 KDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLG 1574
+ + RD + +++ E+ + + K + D+ + + ++ R ++
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 1575 DGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEK 1623
+ D E++L ++ E + ++ ++R + E+LRH+ K E+
Sbjct: 1333 ETDRKFREEEQLLQER--EEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Score = 147 bits (372), Expect = 1e-34
Identities = 238/1264 (18%), Positives = 537/1264 (42%), Gaps = 164/1264 (12%)
Query: 427 RLSAHTILPGSKTRE-PSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESES 485
RLSA L + R+ + +QQ+E+ + ++ +KE + R+ R ++ +F E + +
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 486 SESGE---DDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQH 542
E + ++ D L + S +D L + A+ P+ +Q
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK---PALQEQL 899
Query: 543 TKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPV-------RKR 595
K + + E+ R R E Y E + + + R+R
Sbjct: 900 RKE------QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 596 QE----HRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQE 651
QE +RK L +K+ L G P+ + + KK++ + + + +E+ + +E
Sbjct: 954 QERERQYRKDKKLQQKEEQLL----GEEPEKRRRQEREKKYREEEELQQEEE---QLLRE 1006
Query: 652 LKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDH-FKKEEKLSKMKLEEKEW 710
+ K E+E +K D+ E L E + K +R+ +++EE+L +E+E
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ----QEEEQ 1062
Query: 711 LFKDEKSLKRIKDTNKDISRS----------FREEKDRSNKAEKERSLKEKSP-KEEKLR 759
L +E+ +R ++ + + REE ++ + E+ER +E+ ++E+ +
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 760 LYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKK---EKVYREDSAFDE 816
L +EER+K+ R +LE++ +E+++ +E+E++ +E+ EK ++ E+ YRE+ +
Sbjct: 1123 LLREEREKR---RRQELERQYR-EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 817 YCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKL 876
+ Q L E K +R+R + + + + + YRD S K
Sbjct: 1179 --EEEQLLREEQEK---RRQERERQYREEEELQRQKRKQR--------YRDEDQRSDLKW 1225
Query: 877 ILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSE 936
E KE++ RD++ K E F + +D D+ S++ + + G E
Sbjct: 1226 QWEPEKENAV---RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH------LLGEQQE 1276
Query: 937 KDKKRRESAEAGRDRKDALESCKERRDGR-AKPEEAHREELKECGCESGFKDKSDGDFGK 995
+D+++ RDR E ER + + AK + +E K+ E + + + +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 996 GLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKC 1055
E+ RE++ +++RK + + R++E+ K E+ L + +++++F K
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR-KFLEEEQRLRRQERERKFLK- 1394
Query: 1056 FKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYI 1115
+E++ ++ + +D++RK ++ + +++ E+ ++ +++ K
Sbjct: 1395 -EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK------ 1447
Query: 1116 ADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPER 1175
F +E + R K E L LQE+EE ++ + +R RK +++ R
Sbjct: 1448 ---FLEEEQQLRQE---RHRKFREEEQL-----LQEREE-QQLHRQERDRKFLEEEQQLR 1495
Query: 1176 QKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKD-RKDRASVDSTQDKKN 1234
+++++ + R ++ + + R E+ + H++++ ++ ++ + R+ QD+
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 1235 KQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYRE 1294
K + E+ ++ + ++ + K E K R+ + + + +E + R+
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 1295 DSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSS 1354
+ + K E + +E L ++ R+ L+E+ + R
Sbjct: 1616 ERDRKFRE--DEQLLQEREEQQLHR-----------QERDRKF------LEEEPQLRRQE 1656
Query: 1355 SSSKKSHDRERAKKEKAEKKEKGED-----------YKEGGSRKDSGQYEKDFLEADAYG 1403
+ HDR+R +E+ + ++GE+ ++E + + E+ FL+ +
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 1404 VSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKRE 1463
++ +E E TE++ ER E++L+P +E+ ++
Sbjct: 1717 RRQELERKFREEEQLRQE---TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 1464 KHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGP 1523
+ E+ R E+E + R + + +E LR R+EQ+ L+ + RD
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ------------LRPQQRDGKY 1821
Query: 1524 RLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSF 1583
R + +L+ + ++ +++ D + ++ A +K R ++L + +
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERD--RQYRAEEQFATQ----EKSRREEQELWQEEE------ 1869
Query: 1584 ERMLSQKDLEIEERHKRHKERMKQMEKLRHRS-GDPKLKE---KAKPADDGRKKGLDIPA 1639
++ +++ ++ E H R +Q E+ RHR G+ K +E + + G + +P
Sbjct: 1870 QKRRQERERKLREEHIRR----QQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPV 1925
Query: 1640 KKPP 1643
+ P
Sbjct: 1926 RSSP 1929
Score = 129 bits (325), Expect = 3e-29
Identities = 191/1034 (18%), Positives = 465/1034 (44%), Gaps = 117/1034 (11%)
Query: 662 EDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKM-KLEEKEWLFKDEKSLKR 720
ED ++ + LE + + K + +R+ + EE+ K +LE+++ +DE+ ++
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ 176
Query: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN 780
++ + R EE+ +S K + E+ P EE+LR +E + + K R K +++
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHET----EEFPDEEQLRR-RELLELRRKGREEKQQQRR 231
Query: 781 DLKEDKISKEKEKIFKEDKEK--LKKEKVYR--EDSAFDEYCNKNQFLENED---TKFSL 833
+ ++++F+E++EK K+E V R E+ +E + + L+ E+ K
Sbjct: 232 E--------RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 834 SDDQRDRWFSDLS------DSSFDFKGEDSWDSPVTDYRDM--KSDSVAKLILETVKEDS 885
+ +R+R + + K E+ + R+ + + + + ++ +
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 886 KERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQ---TEKHKSVPGYLSEKDKKRR 942
+ERR RE+ + R +++++ + + R+EQ E+ L + + RR
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403
Query: 943 E-----SAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGL 997
E + R+++ E R + E+ H +E +E + +++ D+ K
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR--DWLKRE 461
Query: 998 EPWERHHPAREKEK-KDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCF 1056
E ERH R K++ K ++ER+E+ +E+ +++ E+ + ++++E
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL----RREQE----- 512
Query: 1057 KEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIA 1116
E+++ + K ++ + ++R S Q + ++E+ ++ + ++ + ++ +++
Sbjct: 513 -ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR----- 566
Query: 1117 DIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQ 1176
E E+ RD + K E R QE+ + + R +++ +R
Sbjct: 567 --LKREQEERRDQLL----KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 1177 KDKEPRDRRK----------DRGAADAGRDKKEKVFEKHKEKKDKESTEK------YKDR 1220
K +EP + R+ +R R+++E+ ++ K ++++E E+ ++R
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 1221 KDRASVDSTQD---KKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAE 1277
+++ + Q+ ++ K ++P+ + + D +SK + K+ + R+ +
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 1278 K--SLLEKLEEEALH---EYREDSNDKISEVSSDSFTDRGQE-----PGLTAFLEVSFTE 1327
+ S L+ EEE H + E D + ++ ++RG++ P L E
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 1328 PPGDDKPRESACLPEKLKEKERHRHSSSSSKK----SHDRERAKKEKAEKKEKGED-YKE 1382
+ + RE LPE+ ++++R R K+ + + ++E+A++ ++ ED +E
Sbjct: 801 E--ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 1383 GGSRKDSGQYEKD-----FLEADAYGVSYNM--KADIEDELDKTIELFSTEKKDKNDSER 1435
R+ S + +D LE + + + K ++++L K +L E+++ ER
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 1436 EPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRH 1495
E ++ E+E + + +E+ RE+ REK R +ER R D L+ ++LL
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREE-REK-RRRQERERQYRKDKKLQQKEEQLLGE 976
Query: 1496 HRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEK-EKGDPVKMSNGNDK 1554
++++ R+K R ++ ++E L + + K + ++ + K D ++ ++
Sbjct: 977 EPEKRRRQEREKKY--REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ---EEE 1031
Query: 1555 VAPSKDPGKKDARPREKLLGDGDLMMTSFERML-----SQKDLEIEERHKRHKERMKQME 1609
++ K+ + RE+ + + + E++L +++ E+E ++++ +E ++ E
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 1610 KLRHRSGDPKLKEK 1623
+L + + +++
Sbjct: 1092 QLLREEPEKRRRQE 1105
Score = 120 bits (302), Expect = 1e-26
Identities = 166/992 (16%), Positives = 436/992 (43%), Gaps = 119/992 (11%)
Query: 714 DEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRP 773
DE+ R D + + + R+E+D+ ++R L+E+ + + + ++ER+ +
Sbjct: 96 DEEKRARC-DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 774 SKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAF--------DEYCNKNQFLE 825
S EK+ L++ + E+++++ +E ++E+ E+ +E+ ++ Q
Sbjct: 155 S--EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 826 NEDTKFSLSD-DQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKED 884
E + +++ + + D F + E W K ++V + E ++E+
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEW---------RKRETVLRKEEEKLQEE 263
Query: 885 SKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRES 944
+R+R+ + E++ RK +R L + ++ ++Q ++ + +++++RRE
Sbjct: 264 EPQRQRELQEEEEQ------LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 945 AEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHH 1004
E R++++ E +ERR+ + + E+ R E + + + + + + E+
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQ-------LRREQEEERREQQLRREQEE 370
Query: 1005 PAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKE 1064
RE++ + R+++ + E+ + + ++ L + Q+ + + +E++ +E
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQQLRREQQLRREQQLRRE 428
Query: 1065 KHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESE 1124
+ ++ H + E++ + K ++E+ + E+ +E+ + ++ K++ + D+ E
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ------LKRDQEE 482
Query: 1125 DDRDSCMGSGFKMGEASDLPRTDGL-QEKEEGRE----------------------AYAS 1161
+ R+ + + R L +E+EE RE
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 1162 DRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK 1221
+ R+ K+ E++ ++E R++R R + ++ E+ +++ +E E+ + R
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 1222 DRASVDS-TQDKKNKQKL----PEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADA 1276
R V+ Q+++ +Q+L PE+ ++ + + + + +++ + +ER+ R
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 1277 EKSLLEKLEEEALHEYREDSND-KISEVSSDSFTDRGQ------EPGLTAFLEVSFTEPP 1329
E+ E+LE+ E+ E+ + +++E + +R + + L + + ++
Sbjct: 663 EEE--ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 1330 GDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKE-----KGEDYKEGG 1384
+ +E ++ +EK R R S ++ R ++E+ ++++ + E+ E G
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 1385 SRKDSG------QYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPS 1438
++ S Q E+ + + E++ + + EK+ + E E
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 1439 KKIEK--ELKPYGSSAINILKEKKKREKHRE---KWRDEKERHRDRHA------------ 1481
++ E+ +L+ + ++ +E+ R+ +W+ E+ER R RH
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 1482 --DGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAE 1539
LL+ +EL R R++++ ++++ R + ++E L + + K + ++
Sbjct: 901 KEQQLLQEEEEELQREEREKRR--RQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 1540 KEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERML----SQKDLEIE 1595
+ + D K ++ ++P K+ + REK + + + E++L ++ +
Sbjct: 959 QYRKD--KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 1596 ERHKRHKERMKQMEK--LRHRSGDPKLKEKAK 1625
ER R K+ ++Q E+ LR +L+E+ +
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 132 bits (331), Expect = 6e-30
Identities = 99/311 (31%), Positives = 147/311 (47%), Gaps = 43/311 (13%)
Query: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
++NKRN RGE++LH A RG+ +K LI GADVN+ D AGWT LHEA N G D+ +
Sbjct: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
Query: 220 LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279
LL AGA+VN + +D PLHDA N H K ++LL+ G NP Q ++K ++ L A+ M
Sbjct: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKM 1266
Query: 280 VNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSV-----DGNNTDSEFEKGLKHKAKNP 334
LL G + +++ E P+ DG DS L H+ ++
Sbjct: 1267 KELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDS---SSLSHQERSR 1323
Query: 335 EP----QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
E Q +A ++D E E +LL+ + R + +I KM
Sbjct: 1324 ESLSVHQTLSAILQDIEEKQE-------------YLLEFEIRNPEDAEQYIE--KMLKIK 1368
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN-AKQQK 449
+N +A +KA L+ +K R+S + G+ + +N A +QK
Sbjct: 1369 KIMDNVLAKQKAERDDLA---------------KKYRVSIESFKHGALREQLANLAARQK 1413
Query: 450 EKNKVKKKRKK 460
V KK+KK
Sbjct: 1414 SLLVVAKKQKK 1424
Score = 117 bits (293), Expect = 2e-25
Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 21/230 (9%)
Query: 147 QKGTPNSASKTKDKVNK--------RNERGETRLHRAAIRGDARRIKELISEGADVNVKD 198
+K S K K KVNK RN GE +++AA+ DA + I +G +VN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 199 FAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGG 258
+AGWTALHEA G+Y A +LL GA+VN KGL TPLHDA NGHYKV +LLL G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 259 NPQQSNRKGETPLKVANSPTMVNLL-----LGKGTYTSSEESSTESSEEEDA-----PSF 308
+P N G+ L A M LL + TS++ SS + + ED P F
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKF 639
Query: 309 APSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV--KDEYEFDEDDEQD 356
+ S + ++ + L+H N + KA+ + +D YE+ + D ++
Sbjct: 640 SSKSHIWHVYNENSNRQKLEHVKVN-KGSKASLFINKEDVYEYYQKDPKN 688
Score = 33.1 bits (74), Expect = 3.8
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 70 QKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESA 129
+K + K G + RI K ++ L L+ R PL V L++ A+ +
Sbjct: 1133 EKKEISHKPGMKAGRINKRNARGESQL----HLAVRRGNLPL-----VKALIESGADVNL 1183
Query: 130 NSPVDTTPKHPSQSTVCQKGTPN---SASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
N TP H + + +G+ + K KVN N G LH A + +
Sbjct: 1184 NDNAGWTPLHEASN----EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEI 1239
Query: 187 LISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDD 234
L+ GA+ N KD +AL EA + + K+LL + + T D+
Sbjct: 1240 LLQNGANPNQKDQKQKSALDEADD----EKMKELLRSYGAIETVNRDE 1283
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 132 bits (331), Expect = 6e-30
Identities = 99/311 (31%), Positives = 147/311 (47%), Gaps = 43/311 (13%)
Query: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
++NKRN RGE++LH A RG+ +K LI GADVN+ D AGWT LHEA N G D+ +
Sbjct: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
Query: 220 LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279
LL AGA+VN + +D PLHDA N H K ++LL+ G NP Q ++K ++ L A+ M
Sbjct: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKM 1266
Query: 280 VNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSV-----DGNNTDSEFEKGLKHKAKNP 334
LL G + +++ E P+ DG DS L H+ ++
Sbjct: 1267 KELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDS---SSLSHQERSR 1323
Query: 335 EP----QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
E Q +A ++D E E +LL+ + R + +I KM
Sbjct: 1324 ESLSVHQTLSAILQDIEEKQE-------------YLLEFEIRNPEDAEQYIE--KMLKIK 1368
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN-AKQQK 449
+N +A +KA L+ +K R+S + G+ + +N A +QK
Sbjct: 1369 KIMDNVLAKQKAERDDLA---------------KKYRVSIESFKHGALREQLANLAARQK 1413
Query: 450 EKNKVKKKRKK 460
V KK+KK
Sbjct: 1414 SLLVVAKKQKK 1424
Score = 117 bits (293), Expect = 2e-25
Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 21/230 (9%)
Query: 147 QKGTPNSASKTKDKVNK--------RNERGETRLHRAAIRGDARRIKELISEGADVNVKD 198
+K S K K KVNK RN GE +++AA+ DA + I +G +VN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 199 FAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGG 258
+AGWTALHEA G+Y A +LL GA+VN KGL TPLHDA NGHYKV +LLL G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 259 NPQQSNRKGETPLKVANSPTMVNLL-----LGKGTYTSSEESSTESSEEEDA-----PSF 308
+P N G+ L A M LL + TS++ SS + + ED P F
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKF 639
Query: 309 APSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV--KDEYEFDEDDEQD 356
+ S + ++ + L+H N + KA+ + +D YE+ + D ++
Sbjct: 640 SSKSHIWHVYNENSNRQKLEHVKVN-KGSKASLFINKEDVYEYYQKDPKN 688
Score = 33.1 bits (74), Expect = 3.8
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 70 QKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESA 129
+K + K G + RI K ++ L L+ R PL V L++ A+ +
Sbjct: 1133 EKKEISHKPGMKAGRINKRNARGESQL----HLAVRRGNLPL-----VKALIESGADVNL 1183
Query: 130 NSPVDTTPKHPSQSTVCQKGTPN---SASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
N TP H + + +G+ + K KVN N G LH A + +
Sbjct: 1184 NDNAGWTPLHEASN----EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEI 1239
Query: 187 LISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDD 234
L+ GA+ N KD +AL EA + + K+LL + + T D+
Sbjct: 1240 LLQNGANPNQKDQKQKSALDEADD----EKMKELLRSYGAIETVNRDE 1283
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 132 bits (331), Expect = 6e-30
Identities = 99/311 (31%), Positives = 147/311 (47%), Gaps = 43/311 (13%)
Query: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
++NKRN RGE++LH A RG+ +K LI GADVN+ D AGWT LHEA N G D+ +
Sbjct: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
Query: 220 LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279
LL AGA+VN + +D PLHDA N H K ++LL+ G NP Q ++K ++ L A+ M
Sbjct: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKM 1266
Query: 280 VNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSV-----DGNNTDSEFEKGLKHKAKNP 334
LL G + +++ E P+ DG DS L H+ ++
Sbjct: 1267 KELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDS---SSLSHQERSR 1323
Query: 335 EP----QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
E Q +A ++D E E +LL+ + R + +I KM
Sbjct: 1324 ESLSVHQTLSAILQDIEEKQE-------------YLLEFEIRNPEDAEQYIE--KMLKIK 1368
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN-AKQQK 449
+N +A +KA L+ +K R+S + G+ + +N A +QK
Sbjct: 1369 KIMDNVLAKQKAERDDLA---------------KKYRVSIESFKHGALREQLANLAARQK 1413
Query: 450 EKNKVKKKRKK 460
V KK+KK
Sbjct: 1414 SLLVVAKKQKK 1424
Score = 117 bits (293), Expect = 2e-25
Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 21/230 (9%)
Query: 147 QKGTPNSASKTKDKVNK--------RNERGETRLHRAAIRGDARRIKELISEGADVNVKD 198
+K S K K KVNK RN GE +++AA+ DA + I +G +VN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 199 FAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGG 258
+AGWTALHEA G+Y A +LL GA+VN KGL TPLHDA NGHYKV +LLL G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 259 NPQQSNRKGETPLKVANSPTMVNLL-----LGKGTYTSSEESSTESSEEEDA-----PSF 308
+P N G+ L A M LL + TS++ SS + + ED P F
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKF 639
Query: 309 APSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV--KDEYEFDEDDEQD 356
+ S + ++ + L+H N + KA+ + +D YE+ + D ++
Sbjct: 640 SSKSHIWHVYNENSNRQKLEHVKVN-KGSKASLFINKEDVYEYYQKDPKN 688
Score = 33.1 bits (74), Expect = 3.8
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 70 QKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESA 129
+K + K G + RI K ++ L L+ R PL V L++ A+ +
Sbjct: 1133 EKKEISHKPGMKAGRINKRNARGESQL----HLAVRRGNLPL-----VKALIESGADVNL 1183
Query: 130 NSPVDTTPKHPSQSTVCQKGTPN---SASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
N TP H + + +G+ + K KVN N G LH A + +
Sbjct: 1184 NDNAGWTPLHEASN----EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEI 1239
Query: 187 LISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDD 234
L+ GA+ N KD +AL EA + + K+LL + + T D+
Sbjct: 1240 LLQNGANPNQKDQKQKSALDEADD----EKMKELLRSYGAIETVNRDE 1283
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 125 bits (315), Expect = 4e-28
Identities = 73/186 (39%), Positives = 100/186 (53%), Gaps = 3/186 (1%)
Query: 150 TPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEAC 209
+P++ + KRN RGET LH A+I+GD ++ L+ G+D NVKD AGWT LHEAC
Sbjct: 410 SPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEAC 469
Query: 210 NRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGET 269
N G+ V + LL A VNT G +D+PLHDAA NGH +VKLLL YG + N G
Sbjct: 470 NHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLR 529
Query: 270 PLKVANSPTMVNLLL---GKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKG 326
P+ + +M +LLL + ++S S + + D P S + E
Sbjct: 530 PVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELA 589
Query: 327 LKHKAK 332
+ KAK
Sbjct: 590 VILKAK 595
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 124 bits (310), Expect = 2e-27
Identities = 201/887 (22%), Positives = 371/887 (41%), Gaps = 124/887 (13%)
Query: 725 NKDISRSFREEKDRS-NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLK 783
NKD+ + E+K++S +K EK+ EK ++++ K+E+ +K D K E +K
Sbjct: 304 NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKE----KKEKTEKKFDHSKKSEDTQKVK 359
Query: 784 EDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFS 843
++K +KEKE + KL EK NK + +E FSL D D +
Sbjct: 360 DEKQAKEKE----VESLKLPSEK----------NSNKAKTVEGTKEDFSLIDSDVD-GLT 404
Query: 844 DLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKED------SKERRRDSRAREK 897
D++ SS S++ T+ + SDS+ + + + E+ +K + DS +
Sbjct: 405 DITVSSVHTSDLSSFEED-TEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKT 463
Query: 898 RDYREPFFRKK---DRDYLDKNSEKRKEQTEKH--KSVPGYLSEKDKKRRESAEAGRDRK 952
+ R + K + Y D + E EQ + K L + R + E + +
Sbjct: 464 KSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
Query: 953 DALESCKERRDGRAKP--EEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKE 1010
+ +S K + GR+ EE+ + L+ K + K + E+ +K
Sbjct: 524 EKTKSSKTKGQGRSSVDLEESSTKSLEP-------KAARIKEVLKERKVLEKKVALSKKR 576
Query: 1011 KKDGPDKERKEKTKPERYKEKSSDKDK-SEKSILEKCQKDKEFDKCFKEKKDTKEKHK-- 1067
KKD + E K K ++Y+E S + K SE EK KE + + +K +
Sbjct: 577 KKDSRNVEENSK-KKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLS 635
Query: 1068 -DTHGKDKERKASLDQGKEKKEKAFPGIIS--EDFSEKKDDKKGKEKSWYIADIFTDESE 1124
H D+ + S + + K+ + P I+ ++ ++ +D K+ E+S +I T+E +
Sbjct: 636 ESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERS----EICTEEPQ 691
Query: 1125 DDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQK---DKEP 1181
+ + + S+ P L +KE S K+ PER+K + +
Sbjct: 692 KQKSTLKNEKHLKKDDSETPHLKSLLKKE------------VKSSKEKPEREKTPSEDKL 739
Query: 1182 RDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDK---KNKQKL 1238
+ K +G + ++ K K +E+ +K + +S D T+ K +N++KL
Sbjct: 740 SVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKL 799
Query: 1239 PEKAEKKHAAEDKAKSKHKEKSDKEHSKE-RKSSRSADAEKSLLEKLEEEALHEYREDSN 1297
+ + K S++ K+D+ KE K R AEK+ +A H+ R S+
Sbjct: 800 SVLGK-----DGKPVSEYIIKTDENVRKENNKKERRLSAEKT-------KAEHKSRRSSD 847
Query: 1298 DKISEVSSDSFTDRGQEPGLT-AFLEVSFTEP--PGDDKPRESACLPEKLKEKERHRHSS 1354
KI + S S ++ G+T S++E D +S PE++ KE+ R S
Sbjct: 848 SKIQKDSLGS-----KQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKS 902
Query: 1355 SSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIED 1414
+K + ++K + + K + +EG +++ + +
Sbjct: 903 LLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTP---------------------KP 941
Query: 1415 ELDKTIELFSTEKKDKNDSEREPSKK--IEKELKPYGSSAINILKEKKKREK---HREKW 1469
+ +K E +EK+ K+ E +P ++ +E L+ SSA + K+ R K +EK+
Sbjct: 942 DKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKY 1001
Query: 1470 RDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAK 1529
+ +K+ R L H+ L+H + K +K + S E R G++
Sbjct: 1002 KSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKAR-GNSS 1060
Query: 1530 LKEK--FKDGAEKEKGD-PVKMSNGNDKVAP---SKDPGKKDARPRE 1570
L EK + E +G +M+ G +K+A S G RP++
Sbjct: 1061 LMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK 1107
Score = 114 bits (286), Expect = 1e-24
Identities = 244/1127 (21%), Positives = 429/1127 (38%), Gaps = 169/1127 (14%)
Query: 410 TSDEEDASVTVGTGE----KLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGR 465
TS ++AS + E K A LP T + S K++ ++ K++ G
Sbjct: 209 TSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGG 268
Query: 466 E-VRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTS 524
E + +S++F E ++ + ++L L+ KD SS + ++
Sbjct: 269 EGLETAPKSEEFSDLPCPVEEIKNYTKEHNNL---------ILLNKDVQQESSEQKNKST 319
Query: 525 SHGSSAA--------QKQNPSHTDQHTKHWR----TDNWKTISSPAWSEVSSL------- 565
G +K+ T++ H + T K EV SL
Sbjct: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKN 379
Query: 566 SDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKE 625
S+ +T ++ D+S S V+ L + H S E+ + E +E
Sbjct: 380 SNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDT----EEEVVTSDSMEE 435
Query: 626 GKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYED-----SKQKSDKAILLENDLST 680
G++ + K+K +NK K Q S S E K KS + Y SK SD +++L+
Sbjct: 436 GEITSDDEEKNK-QNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDS----DDELTV 490
Query: 681 ENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSN 740
E + + + +++ ++++ KLEEK K + S + + RS+
Sbjct: 491 EQRRQSIAKEKEERLLRRQINREKLEEKR------------KQKAEKTKSSKTKGQGRSS 538
Query: 741 KAEKERSLKEKSPKEEKLR-LYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDK 799
+E S K PK +++ + KE + + K SK KK+ ++ SK+K++ ++ K
Sbjct: 539 VDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
Query: 800 EKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWD 859
E LK E+C K + +++ K + + + LS+ S E+ +
Sbjct: 599 ETLKT----------SEHCEKEKISSSKELKHVHAKSEPSKPARRLSE-SLHVVDENKNE 647
Query: 860 SPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
S + R+ K + +I+E V+E++ R + E ++K +K+ +K
Sbjct: 648 SKLE--REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKK 705
Query: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREEL--- 976
+T KS+ L ++ K +E E + + S K + G + EL
Sbjct: 706 DDSETPHLKSL---LKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSS 762
Query: 977 -KECGCESGFKDKSDGDFGKGLEPWERHHPAREKEK-----KDG----------PDKERK 1020
K E + +S + ER R + K KDG + RK
Sbjct: 763 EKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRK 822
Query: 1021 EKTKPER--YKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKA 1078
E K ER EK+ + KS +S K QKD K+ T ++ +++ +DK
Sbjct: 823 ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGS---KQHGITLQRRSESYSEDKCDMD 879
Query: 1079 SLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138
S + K + EK+ K E+ + +S+ ++
Sbjct: 880 STNMDSNLKPEEVV------HKEKRRTKSLLEEKL----VLKSKSKTQGKQVKVVETELQ 929
Query: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
E + T +KE+ E S++ RKS + P + EP A +D
Sbjct: 930 EGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSS 989
Query: 1199 EKV---FEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK 1255
+ K K K DK+ST +RK D + L KH+++D K K
Sbjct: 990 HRAKLPLAKEKYKSDKDSTSTRLERK-------LSDGHKSRSL------KHSSKD-IKKK 1035
Query: 1256 HKEKSDKEHSKERKSS-RSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQE 1314
+ KSD + KE SS A SL+EK L E R S +S+ + +G+E
Sbjct: 1036 DENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGS---LSQEMA-----KGEE 1087
Query: 1315 PGLTAFLEVSFTEPPGD--DKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAE 1372
+ + P G +P++S + +++ S + + + + +
Sbjct: 1088 ----KLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNN 1143
Query: 1373 KKEKGEDYKEGGSRKDSGQYEKDFLE---------ADAY------GVSYNMK--ADIEDE 1415
++ D E +K S +KD L A AY GV+ N + AD
Sbjct: 1144 NSQQDID-SENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRST 1202
Query: 1416 LDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKR 1462
L K + + S K N E+EP + G++ +NI E R
Sbjct: 1203 LTKKMHIQSAVSK-MNPGEKEPIHR--------GTTEVNIDSETVHR 1240
Score = 113 bits (283), Expect = 2e-24
Identities = 249/1144 (21%), Positives = 420/1144 (36%), Gaps = 168/1144 (14%)
Query: 258 GNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGN 317
GN + K +T L PT S E+ T ++E A A +S+ N
Sbjct: 170 GNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASA---ARASTETSN 226
Query: 318 NTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKS 377
SE +A P + T + E +D D+ D + +++
Sbjct: 227 AKTSE-------RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
Query: 378 NSFISIPKMEVKSYTK--NNTIAPKKASHRILSDTSDEEDASVTVG-------------- 421
S + P E+K+YTK NN I K + ++S++++ S G
Sbjct: 280 FSDLPCPVEEIKNYTKEHNNLILLNK---DVQQESSEQKNKSTDKGEKKPDSNEKGERKK 336
Query: 422 -TGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKK---RKKETKGREVRFGKR----- 472
EK T++ + KQ KEK K K K + V K
Sbjct: 337 EKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLI 396
Query: 473 -------SDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSS 525
+D SS S+ S ED + + +S ++ + D + + + T +
Sbjct: 397 DSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEK-NKQNKTKTQT 455
Query: 526 HGSSAAQKQNPSHTDQH-----TKHWR-TDNWKTISSPAWSEVSSLSDS-TRTRLTSESD 578
SS + ++ H H +K++ +D+ T+ S + R ++ E
Sbjct: 456 SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515
Query: 579 YSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKH 638
E K + + + R L E + L + ++ KE KV++K K
Sbjct: 516 EEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKK 575
Query: 639 KNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEE 698
+ K+ +E K YE EDSK+ + E + + + K LKH H K E
Sbjct: 576 RKKDSRNV---EENSKKKQQYE-EDSKETLKTSEHCEKEKISSS--KELKH--VHAKSEP 627
Query: 699 KLSKMKLEEKEWLFKDEKSLKRIKDTNKD------ISRSFREEKD-RSNKAEKERS-LKE 750
+L E + + K+ +++ +K I +EE D R K + ERS +
Sbjct: 628 SKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICT 687
Query: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEK--KNDLKEDKISKEKEKIFKED----KEKLKK 804
+ P+++K L E+ KK L+ K ++K K E+EK ED K K K
Sbjct: 688 EEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKG 747
Query: 805 EKVYREDSAFDEYCN-------KNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDS 857
+ +++ + + + +N +++ TK S SDD+ +R ++ G+D
Sbjct: 748 DCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLS-SDDKTERKSKHRNERKLSVLGKDG 806
Query: 858 WDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS 917
PV++Y ++V KE++K+ RR S + K ++ K R D
Sbjct: 807 --KPVSEYIIKTDENVR-------KENNKKERRLSAEKTKAEH-------KSRRSSDSKI 850
Query: 918 EKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEE-AHREE- 975
+K +++H ++R ES +D + D KPEE H+E+
Sbjct: 851 QKDSLGSKQHGITL-------QRRSESYS-----EDKCDMDSTNMDSNLKPEEVVHKEKR 898
Query: 976 ----LKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEK 1031
L E K K+ G K +E E A ++ PDKE+ + + K
Sbjct: 899 RTKSLLEEKLVLKSKSKTQGKQVKVVET-ELQEGATKQATTPKPDKEKNTEENDSEKQRK 957
Query: 1032 SSDKDK------------SEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS 1079
S +DK + S QKD K+ + KD+ ERK S
Sbjct: 958 SKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLS 1017
Query: 1080 LDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGE 1139
D K + K I + K DDK GKE E R + K+
Sbjct: 1018 -DGHKSRSLKHSSKDIKKKDENKSDDKDGKE--------VDSSHEKARGNSSLMEKKLSR 1068
Query: 1140 ASDLPRTDGL-QEKEEGREAYASD--RHRKSSDKQHPERQKD------KEPRDRRKDRGA 1190
R L QE +G E A++ S Q P++ D +EP + + G
Sbjct: 1069 RLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGV 1128
Query: 1191 ADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAED 1250
E VFE K T+ ++ + +DS K+ +K E + D
Sbjct: 1129 --------ENVFEVSK-------TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTAD 1173
Query: 1251 KAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLE-EEALHEYREDSNDKI----SEVSS 1305
+ K + S + AD +L +K+ + A+ + + I +EV+
Sbjct: 1174 SKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNI 1233
Query: 1306 DSFT 1309
DS T
Sbjct: 1234 DSET 1237
Score = 52.0 bits (123), Expect = 8e-06
Identities = 113/553 (20%), Positives = 204/553 (36%), Gaps = 76/553 (13%)
Query: 1154 EGREAYASDRHRKSSDKQHP-ERQKDKEPRDRR---KDRGAADAGRDKKEKVFEKHKEKK 1209
E A S+R K Q + DKE K++ AD+G + E K +E
Sbjct: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA-PKSEEFS 281
Query: 1210 D--------KESTEKYKD----RKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK 1257
D K T+++ + KD S Q K+ K +K + E K + K K
Sbjct: 282 DLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEK 341
Query: 1258 EKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGL 1317
+ +HSK+ + ++ EK EK E E+L E +++K V + +
Sbjct: 342 TEKKFDHSKKSEDTQKVKDEKQAKEK-EVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDV 400
Query: 1318 TAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKG 1377
+++ + D + E +E+ S + + D E K+ + K +
Sbjct: 401 DGLTDITVSSVHTSD----LSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQN-KTKTQT 455
Query: 1378 EDYKEGGSRKDSGQY-EKDFLEADAYGVSYN-----------MKADIEDELDKTIELFST 1425
D EG ++ Y K +L + Y S + K E L + I
Sbjct: 456 SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515
Query: 1426 EKKDKNDSEREPSKKIE--------------KELKPYGSSAINILKEKKKREKH--REKW 1469
E+K K +E+ S K + K L+P + +LKE+K EK K
Sbjct: 516 EEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKK 575
Query: 1470 RDEKERHRDRHADGLLRHHRD--ELLR--HHRDEQK----------PATRDKDSPPRVLK 1515
R + R+ + ++ ++ D E L+ H +++K A + P R L
Sbjct: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLS 635
Query: 1516 DKSRDEGPRLGDAKLKEKFK---------DGAEKEKGD-PVKMSNGNDKVAPSKDPGKKD 1565
+ ++KL+ + K +G ++E VK ++ + +K
Sbjct: 636 ESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKS 695
Query: 1566 ARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHR-SGDPKLKEKA 1624
EK L D + +L ++ +E+ +R K + ++H+ GD K
Sbjct: 696 TLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGD 755
Query: 1625 KPADDGRKKGLDI 1637
+ +KGL +
Sbjct: 756 ETELHSSEKGLKV 768
Score = 51.6 bits (122), Expect = 1e-05
Identities = 113/566 (19%), Positives = 196/566 (34%), Gaps = 127/566 (22%)
Query: 1224 ASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLE- 1282
AS + + K E+A KK ++ +D KER S AD EKS +
Sbjct: 215 ASAARASTETSNAKTSERASKKLPSQPT--------TDTSTDKERTSEDMADKEKSTADS 266
Query: 1283 ---------KLEE--------EALHEYREDSNDKI---SEVSSDSFTDRGQEPGLTAFLE 1322
K EE E + Y ++ N+ I +V +S + +
Sbjct: 267 GGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNK--------- 317
Query: 1323 VSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKE 1382
+ G+ KP + K ++KE+ SKKS D ++ K EK K+++ E K
Sbjct: 318 ---STDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKL 374
Query: 1383 GGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIE 1442
+ + + + D + +D++ D T+ S D + E + +++
Sbjct: 375 PSEKNSNKAKTVEGTKEDFSLID----SDVDGLTDITVS--SVHTSDLSSFEEDTEEEVV 428
Query: 1443 KELKPYGSSAINILKEKKKREKHREKWRDEKE------RHRDRHADGLLRHHRDELLRHH 1496
+ +EK K+ K + + D E RH H L + +
Sbjct: 429 TSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDEL 488
Query: 1497 RDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKV- 1555
EQ+ + K+ R+L+ + E KL+EK K AEK K K G V
Sbjct: 489 TVEQRRQSIAKEKEERLLRRQINRE-------KLEEKRKQKAEKTKSSKTK-GQGRSSVD 540
Query: 1556 ---APSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLR 1612
+ +K K AR +E L ER + +K + + ++ K+ +++ K +
Sbjct: 541 LEESSTKSLEPKAARIKEVLK----------ERKVLEKKVALSKKRKKDSRNVEENSKKK 590
Query: 1613 HRSGDPKLKEKAKPADDGRKKGLD-------IPAKKPPG------------LDPPFKDKK 1653
+ + KE K ++ K+ + + AK P +D + K
Sbjct: 591 QQYEEDS-KETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESK 649
Query: 1654 L----KESTPIPPAAENKLHPASGAD----------------------------SKDWLA 1681
L K T P E D KD
Sbjct: 650 LEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSE 709
Query: 1682 GPHMKEVLPASPRPDQSRPTGVPTPT 1707
PH+K +L + + +P TP+
Sbjct: 710 TPHLKSLLKKEVKSSKEKPEREKTPS 735
Score = 49.7 bits (117), Expect = 4e-05
Identities = 74/371 (19%), Positives = 143/371 (38%), Gaps = 68/371 (18%)
Query: 945 AEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFG-------KGL 997
AE R+ ES G EE H E + SG KD ++ G K +
Sbjct: 2702 AELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEV 2761
Query: 998 EPWERHHPAR---------EKEKKDGPDK-----ERKEKTKPERYKEKSSDKDKSEKSIL 1043
E ERH P R E E D PD E ++ PE E K+++ + +
Sbjct: 2762 EEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPET--EPHDTKEENSRDLE 2819
Query: 1044 EKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKK 1103
E + E + + K+++ + ++ + + D + +E+ P II
Sbjct: 2820 ELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR------ 2873
Query: 1104 DDKKGKEKSWYIADIFT--DESEDD------RDSCMGSGFKMGEASDLPR-TDGLQEK-- 1152
K+G+ + + + D+S+ D S S K+ + + + T LQE+
Sbjct: 2874 --KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931
Query: 1153 --EEGREAYASDRHRKS------------SDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
++G E + R+ ++ PER++ K +D DKK
Sbjct: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK---------SVSDPVEDKK 2982
Query: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
E ++ E++++E ++ R++ S + Q P K+ + A+++ ++
Sbjct: 2983 E---QESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQ 3039
Query: 1259 KSDKEHSKERK 1269
+ ++ K+ K
Sbjct: 3040 RVEEAPVKKAK 3050
Score = 42.4 bits (98), Expect = 0.006
Identities = 49/247 (19%), Positives = 103/247 (41%), Gaps = 26/247 (10%)
Query: 1162 DRHRKSSDKQHPERQ----KDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKY 1217
D +++ +Q PE + K++ RD + + +V E+ E E+T +
Sbjct: 2792 DSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK 2851
Query: 1218 KDRKDRASVDSTQDK-----KNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSR 1272
++ D ++ S ++ K K+ P +K+ E K K K+D +S
Sbjct: 2852 PEQNDDDTIKSQEEDQPIIIKRKRGRP----RKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
Query: 1273 SADAEKSLLEKLEEEALH-EYREDSNDKISEVSSDSFTDRGQEP--GLTAFLEVSFTEP- 1328
S+ + ++ +E + + R SND E S RG++P LT + +EP
Sbjct: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPE 2967
Query: 1329 ---------PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGED 1379
P +DK + + E+ +E++ +++ S + +R+K + + ++ +
Sbjct: 2968 RKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKRE 3027
Query: 1380 YKEGGSR 1386
G+R
Sbjct: 3028 VSPPGAR 3034
Score = 36.2 bits (82), Expect = 0.44
Identities = 56/316 (17%), Positives = 119/316 (37%), Gaps = 40/316 (12%)
Query: 1166 KSSDKQHPERQKDKEPRDRRKDRGAADAGR---------DKKEKVFEKHKEKKDKESTEK 1216
+++++ H E E RKD A +G +++E+ K K K+ S+E
Sbjct: 2723 RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSED 2782
Query: 1217 YKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADA 1276
D D V ++ + +++ PE H K + E S++
Sbjct: 2783 EPD--DNPDVLDSRIETAQRQCPET------------EPHDTKEENSRDLEELPKTSSET 2828
Query: 1277 EKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEP--------GLTAFLEVSFTEP 1328
+ +EE+ + E + +K + D+ + ++ G V T
Sbjct: 2829 NSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLK 2888
Query: 1329 PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKD 1388
DD ++ + + + SSS K + + KE A +E+ +G +
Sbjct: 2889 MKDDSKTDTGIVTVE-------QSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIV 2941
Query: 1389 SGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPY 1448
+ + + VS + A+ + K + S +DK + E + ++ E+E +P
Sbjct: 2942 TSVRRRGRKPKRSLTVSDD--AESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPS 2999
Query: 1449 GSSAINILKEKKKREK 1464
G++ + + + +R K
Sbjct: 3000 GATTRSTTRSEAQRSK 3015
Score = 34.3 bits (77), Expect = 1.7
Identities = 72/346 (20%), Positives = 123/346 (35%), Gaps = 35/346 (10%)
Query: 268 ETPLKVANSPTMVNLLLG-KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKG 326
E + N + +N+L G K E+ S EE++ AP S+ G G
Sbjct: 2646 ENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPS-----G 2700
Query: 327 LKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKM 386
+ + P + V++ ++ + +KD + +S + PK
Sbjct: 2701 IAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPK- 2759
Query: 387 EVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK 446
EV+ ++ PK+ + + DE D + V L T EP + K
Sbjct: 2760 EVEEEERH---MPKRKRKQHYLSSEDEPDDNPDV-----LDSRIETAQRQCPETEPHDTK 2811
Query: 447 QQKEKNKVK-KKRKKETKGREVRFGKRSDKFCSSESESESSESGEDD------RDSLGSS 499
++ ++ + K ET R + D++ SSE+ E E +DD D
Sbjct: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIII 2871
Query: 500 GCLKGSP--------LVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNW 551
+G P L +KD S + S ++ K TD+ K
Sbjct: 2872 KRKRGRPRKYPVETTLKMKDD---SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQE 2928
Query: 552 KTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQE 597
++IS+ E + S R R + ES +P RKRQ+
Sbjct: 2929 RSISNDDGEE--KIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 122 bits (305), Expect = 6e-27
Identities = 214/1138 (18%), Positives = 423/1138 (37%), Gaps = 133/1138 (11%)
Query: 623 DKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAIL---LENDLS 679
++ V+K ++ +H+ KE + + + + + E+E ++ SD + ++LS
Sbjct: 106 EESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELS 165
Query: 680 TENK-----LKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFRE 734
E K +++K ++++ +K E++ K E + ++ ++K R
Sbjct: 166 LEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSP 225
Query: 735 EKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEK-KNDLKEDKISKEKEK 793
+ ++K +++ S +++ + KKK PS D+ K KEK K
Sbjct: 226 KSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYK 285
Query: 794 IFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFK 853
+ +EK + K D F+ K + R S S S +
Sbjct: 286 VKDRIEEKTRDGKDRGRD--FERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQ 343
Query: 854 GEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRD-----YREPFFRKK 908
SP + S S + + ++ + S + +R +R P R+K
Sbjct: 344 RH----SPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSP-MREK 398
Query: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALE--SCKERRDGRA 966
R ++ S+ + E+ + G +++K RE E +D+ + + +E RDGR
Sbjct: 399 GRHDHERTSQSHDRRHERREDTRG-KRDREKDSREEREYEQDQSSSRDHRDDREPRDGRD 457
Query: 967 KPEEAHREELKECGCESGFKDKSD-----GDFGKGLEPWERH--HPAREKEKKDGPDKER 1019
+ + + +E +D + D + +P + A + ++G D R
Sbjct: 458 RRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHR 517
Query: 1020 KEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS 1079
KE T PE + + + E S E + + + E D G+ + R
Sbjct: 518 KEDTYPEESRSYGRNHLREESSRTEIRNESR--------NESRSEIRNDRMGRSRGRVPE 569
Query: 1080 LDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGE 1139
L + K + I S + D S+ D + + D+RD S F+
Sbjct: 570 LPE-KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPE--RDNRDQARDSSFE--- 623
Query: 1140 ASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKE 1199
R G +++ + RE R SS +H R + E +RR++R + E
Sbjct: 624 -----RRHGERDRRDNRER----DQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDE 674
Query: 1200 KVFEKHKEK-KDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
+ E+ +E+ +D+E + + +DR + +K ++ E+A ++ +K + + ++
Sbjct: 675 RARERDRERERDRERERERERERDR------EREKERELERERAREREREREKERDRERD 728
Query: 1259 KSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLT 1318
+ D++H +ER+ R D EK + EE RE ++ E + +R +E
Sbjct: 729 R-DRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQ 787
Query: 1319 AFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGE 1378
E DK R+ +EK + + HD ++KK
Sbjct: 788 RDWE-------DKDKGRDDR------REKREEIREDRNPRDGHDERKSKKR--------- 825
Query: 1379 DYKEGGS---RKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSER 1435
Y+ GS R+ + + ++DAY D+ ++ L S + +
Sbjct: 826 -YRNEGSPSPRQSPKRRREHSPDSDAYNSG--------DDKNEKHRLLSQVVRPQESRSL 876
Query: 1436 EPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRH 1495
PS E + +E +K E+ R E++ +++ + + + E+L
Sbjct: 877 SPSHLTEDRQGRW-------KEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILES 929
Query: 1496 HRDEQKPATRDKDSPPRVLKDKSRDEG---PRLGDAKLKEKFKDGAEKEKGDPVKMSNGN 1552
R + S R D++ DE ++ +K+K +D E+G+ S
Sbjct: 930 SRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDG 989
Query: 1553 DKVAPSKDPGKKD-ARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKL 1611
+P K KK + R+K GD D+ D E ++ K+ K
Sbjct: 990 QVFSPKKGQKKKSIEKKRKKSKGDSDI-----------SDEEAAQQSKK---------KR 1029
Query: 1612 RHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPA 1671
R+ KE+ +G+ L+ KK + D+ + + T + A
Sbjct: 1030 GPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATT 1089
Query: 1672 SGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSA 1729
G+ + +LP P + T VP + + + + T S SA
Sbjct: 1090 PGSTPSP------LSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSA 1141
Score = 112 bits (280), Expect = 5e-24
Identities = 193/944 (20%), Positives = 368/944 (38%), Gaps = 154/944 (16%)
Query: 722 KDTNKDISRSFREEKDRSNKAEKE--RSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKK 779
K ++ S R+E R EKE + KE++P+ E+ + E + S + +
Sbjct: 102 KRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYV 161
Query: 780 NDL----KEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSD 835
++L K KI +E K+ +E+ EK ++ + +E S E + LS
Sbjct: 162 HELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSP-------------EVVRSKLSP 208
Query: 836 DQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAR 895
L SS K + S S +D K+ +V+ +L+ ++R +
Sbjct: 209 SP------SLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLD------QQRNSKTNQS 256
Query: 896 EKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDAL 955
+K+ R P + ++ K+ EK+K ++K R+ + GRD
Sbjct: 257 KKKGPRTP----SPPPPIPEDIALGKKYKEKYK----VKDRIEEKTRDGKDRGRD----F 304
Query: 956 ESCKERRDG--RAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKD 1013
E +E+RD P H + S S G ++ RH P+ +++
Sbjct: 305 ERQREKRDKPRSTSPAGQHHSPI------SSRHHSSSSQSGSSIQ---RHSPSPRRKRTP 355
Query: 1014 GPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEK-KDTKEKHKDTHGK 1072
P +R T + +S S ++ Q +EK + E+ +H +
Sbjct: 356 SPSYQR---TLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDR 412
Query: 1073 DKERKASLDQGKEKKEKAFPGIISEDFSEKKD-DKKGKEKSWYIADIFTDESEDDRDSCM 1131
ER+ ED K+D +K +E+ Y D S D RD
Sbjct: 413 RHERR-------------------EDTRGKRDREKDSREEREYEQD--QSSSRDHRDD-- 449
Query: 1132 GSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAA 1191
+E +GR+ R + D + +R++ ++ RD R R
Sbjct: 450 ------------------REPRDGRD------RRDARDTR--DRRELRDSRDMRDSREMR 483
Query: 1192 DAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDK 1251
D RD KE ++ +D ST D +DR D+ + + + + H E+
Sbjct: 484 DYSRDTKES-----RDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
Query: 1252 AKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSS--DSFT 1309
++++ + +S E E ++ R + + + +L E+ R D S S+ DS+
Sbjct: 539 SRTEIRNESRNESRSEIRNDRMGRS-RGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE 597
Query: 1310 DRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSK---KSHDRERA 1366
R P + E + D ++ +ER + SS + ++ + ER
Sbjct: 598 TRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERD 657
Query: 1367 KKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKT-IELFST 1425
++ + + ++ +D ++ +R+ + E+D + + + E EL++
Sbjct: 658 ERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERER 717
Query: 1426 EKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLL 1485
E++ + D ER+ + ++E + + ++ REK RE+ R+E+ER R+R +
Sbjct: 718 EREKERDRERDRDRDHDRERER---------ERERDREKEREREREERERERERERERER 768
Query: 1486 RHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDE------------GPRLG--DAKLK 1531
R+ RD+++ RD + KDK RD+ PR G + K K
Sbjct: 769 ERERERERARERDKERERQRDWED-----KDKGRDDRREKREEIREDRNPRDGHDERKSK 823
Query: 1532 EKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKD 1591
+++++ K + + + + G D + +LL ++ R LS
Sbjct: 824 KRYRNEGSPSPRQSPKRRREHSPDSDAYNSG-DDKNEKHRLL--SQVVRPQESRSLSPSH 880
Query: 1592 LEIEERHKRHKE--RMKQMEKLRHRSGDPKLKEKAKPADDGRKK 1633
L E+R R KE R + ++ R + +LKEK D R++
Sbjct: 881 L-TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQ 923
Score = 110 bits (276), Expect = 1e-23
Identities = 288/1533 (18%), Positives = 564/1533 (36%), Gaps = 250/1533 (16%)
Query: 294 ESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDD 353
E ++EE +P SS G + + E K K + E + E+E + DD
Sbjct: 99 EPQKRNTEESSSPVRKESSR--GRHREKEDIKITKERTPESEEENV------EWETNRDD 150
Query: 354 EQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDE 413
+ D H L + +++ + + + ++ + I K+ S ++
Sbjct: 151 SDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEK--REEIIIKKEVSPEVVRSKLSP 208
Query: 414 EDASVTVGTGEKLRLSAHTILPGSKTREPSNA------KQQKEKNKVKKKRKKETKG--- 464
+ K + S + K R+ S +Q+ K KK+ T
Sbjct: 209 SPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPP 268
Query: 465 ---REVRFGKR-SDKFCSSESESESSESGED------------DRDSLGSSGCLKGSPLV 508
++ GK+ +K+ + E + G+D D+ S SP+
Sbjct: 269 PIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPIS 328
Query: 509 LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDS 568
+ S SS S SS H S +K+ PS + Q +T++ P
Sbjct: 329 SRHHSS-SSQSGSSIQRHSPSPRRKRTPSPSYQ----------RTLTPPL---------- 367
Query: 569 TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKV 628
S S Y S S P RK+ R R+ + EK + D E +
Sbjct: 368 ----RRSASPYPSHSLS----SPQRKQSPPRHRSPMREKG------------RHDHE-RT 406
Query: 629 VKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLK 688
+ H +H+ + +G+ ++ + + YE + S + + + + + +
Sbjct: 407 SQSHDRRHERREDTRGKRDREKDSR-EEREYEQDQSSSRDHRD---DREPRDGRDRRDAR 462
Query: 689 HDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSL 748
RD + + E +D K + +D SRS R+ D ++ ++
Sbjct: 463 DTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRD-----SRSTRDAHDYRDREGRDTHR 517
Query: 749 KEKSPKEEKLRLY-----KEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLK 803
KE + EE R Y +EE + S+ E +++++ D++ + + ++ E +
Sbjct: 518 KEDTYPEES-RSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRV----PELPE 572
Query: 804 KEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRW-----FSDLSDSSFDFK-GE-D 856
K S D + + + + ++ +T+ S + RDR+ DSSF+ + GE D
Sbjct: 573 KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE--RDRYPERDNRDQARDSSFERRHGERD 630
Query: 857 SWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKN 916
D+ D R E +++ +E RR R ++RD R R++DR+
Sbjct: 631 RRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERA---RERDRERERDR 687
Query: 917 SEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREEL 976
+R+ + E+ + E++K+R E R+R+ E ++R R + + RE
Sbjct: 688 ERERERERERDR-------EREKERELERERAREREREREKERDRERDRDRDHDRERERE 740
Query: 977 KECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
+E E K++ ER RE+E+ ++ER+ + + ER +E++ ++D
Sbjct: 741 RERDRE---KER------------EREREERERER----ERERERERERERERERARERD 781
Query: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKH--KDTHGKDKERKASLDQGK-------EKK 1087
K + + KDK D +++++ +E +D H + K +K ++G +++
Sbjct: 782 KERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRR 841
Query: 1088 EKAFPGIISEDFSEKKDDK--------KGKEKSWYIADIFTDE-----SEDDRDSCMGSG 1134
+ P + + + K++K + +E T++ E+DR
Sbjct: 842 REHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKES 901
Query: 1135 FKMGEASDLP-RTDGLQEKEEGREAYASDR-------------HRKSSDKQHPERQK--- 1177
+ E +L + + ++ E E S R R++SD+ H E +K
Sbjct: 902 SRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961
Query: 1178 -DKEPRDRRKD------RGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQ 1230
K+P ++K+ RG + + + K +KK ++ K + D D
Sbjct: 962 IQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEA 1021
Query: 1231 DKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALH 1290
+++K+K + + KE E + ++ E S +K E+ A
Sbjct: 1022 AQQSKKKRGPRT--------------PPITTKEELVEMCNGKNGILEDS--QKKEDTAFS 1065
Query: 1291 EYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERH 1350
++ ++ +EV+ T PG T S PP + +P L
Sbjct: 1066 DWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAA 1125
Query: 1351 RHSSSS---------------------SKKSHDR-ERAKKEKAEKKEKGEDYKEGGSRKD 1388
+S S ++ SH + R + EK E ++ RK
Sbjct: 1126 AATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPH--VTIEDAQHRKP 1183
Query: 1389 SGQYEKDFLEADAYGVSY---NMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKEL 1445
Q L ++ S+ +++ D ++ + S K+ + R+ K E+
Sbjct: 1184 MDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEI 1243
Query: 1446 KPYGSSAINILKE---KKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKP 1502
S I+ LK + R+ R R +D + R ++
Sbjct: 1244 TGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQE-- 1301
Query: 1503 ATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPG 1562
RD+ R + + RD R D + + ++++ + DK
Sbjct: 1302 --RDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDK-------- 1351
Query: 1563 KKDA-RPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEK-LRHRSGDPKL 1620
++D R RE+L+ D +R + + +IE + + + E+ L S D
Sbjct: 1352 RRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLA 1411
Query: 1621 KEKAKPADD-GRKKGLDIPAK--KPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSK 1677
+K + D G +G + K + L+ + KL ++ + A P S +
Sbjct: 1412 LDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELD 1471
Query: 1678 DWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVL 1710
+ LAG A R DQ +P P V+
Sbjct: 1472 EILAG-------DAEKREDQQDEEKMPDPLDVI 1497
Score = 102 bits (254), Expect = 5e-21
Identities = 192/871 (22%), Positives = 342/871 (39%), Gaps = 132/871 (15%)
Query: 890 RDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGR 949
R S R D RE K+ D ++E +K TE+ S R+ES+
Sbjct: 75 RRSPERPTGDLRERMKNKRQ----DVDTEPQKRNTEESSS---------PVRKESSRGRH 121
Query: 950 DRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGK------GLEPWERH 1003
K+ ++ KER E+ E ++ E+ D +GD LE +R
Sbjct: 122 REKEDIKITKERTP------ESEEENVE---WETNRDDSDNGDINYDYVHELSLE-MKRQ 171
Query: 1004 HPAREKEKKDGPDKERKEK------TKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFK 1057
RE K + + E++E+ PE + K S KS K K K K
Sbjct: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKS--SKSPKRKSSPKSSS 229
Query: 1058 -EKKDTKEKHKDTHGKDKERKASLDQGKEK--KEKAFPGIISEDFSEKKDDKKGKEKSWY 1114
KKD K + D++R + +Q K+K + + P I ED + KK KEK +
Sbjct: 230 ASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIAL---GKKYKEK-YK 285
Query: 1115 IADIFTDESEDDRDSCMGSGF-KMGEASDLPRTD---GLQEKEEGREAYASDRHRKSSDK 1170
+ D +++ D +D G F + E D PR+ G ++S SS +
Sbjct: 286 VKDRIEEKTRDGKDR--GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQ 343
Query: 1171 QH---PERQKDKEPRDRRK-----DRGAA-----DAGRDKKEKVFEKH------KEKKDK 1211
+H P R++ P +R R A+ ++++ +H K + D
Sbjct: 344 RHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDH 403
Query: 1212 ESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK-HKEKSDKEHSKERKS 1270
E T + DR+ D T+ K++++K + E++ +D++ S+ H++ + ++R+
Sbjct: 404 ERTSQSHDRRHERRED-TRGKRDREK--DSREEREYEQDQSSSRDHRDDREPRDGRDRRD 460
Query: 1271 SRSADAEKSLLEKLEEEALHEYREDSND-KISEVSSDSFTDRGQEPGLTAFLEVSFTEPP 1329
+R + L + + E R+ S D K S DS + R + +
Sbjct: 461 ARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH---------DYRDRE 511
Query: 1330 GDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAE--------KKEKGEDYK 1381
G D R+ PE+ + R+ SS+ E + ++E + + +
Sbjct: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP 571
Query: 1382 EGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKK-----DKNDSERE 1436
E GSR G Y S+ ++ E D+ E + ++ ++ ER+
Sbjct: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYP-ERDRYPERDNRDQARDSSFERRHGERD 630
Query: 1437 PSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHH 1496
E++ +P ++ +R++ RE ER DR D RDE R
Sbjct: 631 RRDNRERDQRPSSPIRHQGRNDELERDERRE------ERRVDRVDD-----RRDERARE- 678
Query: 1497 RDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVA 1556
RD ++ R+++ +D+ R++ L + +E+ ++ EKE+ +D+
Sbjct: 679 RDRERERDRERERERERERDREREKERELERERARERERE-REKERDRERDRDRDHDRER 737
Query: 1557 P---SKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRH 1613
+D K+ R RE+ +++ E E +R +ER ++ +K R
Sbjct: 738 ERERERDREKEREREREE------------RERERERERERERERERERERARERDKERE 785
Query: 1614 RSGDPKLKEKAKPADDGRKKGLDIPAKKPP--GLDPPFKDKKLKESTPIPPAAENKLHPA 1671
R D + K+K + DD R+K +I + P G D K+ + P K
Sbjct: 786 RQRDWEDKDKGR--DDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE 843
Query: 1672 SGADSKDWLAGPHMKE---VLPASPRPDQSR 1699
DS + +G E +L RP +SR
Sbjct: 844 HSPDSDAYNSGDDKNEKHRLLSQVVRPQESR 874
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 117 bits (294), Expect = 1e-25
Identities = 186/964 (19%), Positives = 415/964 (43%), Gaps = 120/964 (12%)
Query: 384 PKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVG-TGEKLRLSAHTILPGSKTREP 442
P M K T+ N +A K +D A V G T K + H P + T
Sbjct: 11 PMMSEK--TRQNKLAEAKKK---FTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGG 65
Query: 443 SNAKQQKEKNKVKKKRKK-------ETKGREVRFGKRSDKFCSSE-SESESSESGEDDRD 494
++ + ++N+ + K +K E RE+ + + + + +E E++ D
Sbjct: 66 CHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAA 125
Query: 495 SLGSSGCLKGSP----LVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDN 550
G L G+P L L S L STS + H H+ H+ +
Sbjct: 126 RKFEDGNL-GTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLH---HSWHFAGEL 181
Query: 551 WKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSP 610
+ +S A S +D LT E D S+E + +E +K+ + ++K P
Sbjct: 182 QRALS--AVSTRHKKADRYIEELTKERD----ALSLELYRNTITNEELKKKNAELQEKLP 235
Query: 611 FLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDK 670
S + + KE K + E+ + + Q +++ T + E +Q
Sbjct: 236 LAESEKSEIQLNVKELK-----------RKLERAKFLLPQ---VQTNTLQEEMWRQ---- 277
Query: 671 AILLENDLSTENKLKVLKHDRDHFKKEEKLSKMK---LEEKEWLFKDEKSLKRIKDTNKD 727
E +L + K K+ K + +++EE+L + + E++E +++ EK L+ + ++
Sbjct: 278 ----EEELREQEK-KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELRE 332
Query: 728 ISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKI 787
+ RE+K+ + E+ + +EK ++E+ +EE+ + ++R + EK+ +E K+
Sbjct: 333 QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM 392
Query: 788 SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSD 847
++E+++++D+ +KE+ RE E K + + + + DQ ++
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK------- 445
Query: 848 SSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRK 907
M+ + + + ++E+ + R +K++ E + +
Sbjct: 446 --------------------MQEEERIREREKKMREEEETMREQEEKMQKQE--ENMWEQ 483
Query: 908 KDRDYLDKNSEKRKE---QTEKHKSVPGYLSEKDKKRRESAEA-GRDRKD-ALESCKERR 962
+++++ + ++KE + EK + + E+++K R+ E G+++K E +E+
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 963 DGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKE---- 1018
D + EE R++ ++ + +K + K + W++ RE+E+ +K+
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK--KTWDQEEKMREEERMREREKKMREE 601
Query: 1019 ----RKEKTKPERYKEKSSDKDKSEKSILEKCQKDKE-----FDKCFKEKKDTKEKHKDT 1069
R+++ K + +EK ++++ EK Q+ +E +K +++++ E+ +
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 1070 HGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDS 1129
K+K + Q +EK ++ I ++ EKK ++ K K+W + +ES +R+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK-KTWDQEKMREEESMREREK 720
Query: 1130 CMGSGFKMGEASDLPR--TDGLQEKEEGREAYASDRHRKSSDK-QHPERQKDKEPRDRRK 1186
KM E ++ R + +QE+EE + + + + E+ +++ +K
Sbjct: 721 ------KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774
Query: 1187 DRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNK-----QKLPEK 1241
++ ++EK++E+ ++ +D+E + ++ K R + + ++ K +K+ +
Sbjct: 775 EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834
Query: 1242 AEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKIS 1301
EK E+K + ++ +K +E K + + EK+ E+ E +KI
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ--EEKMRGQEEKIY 892
Query: 1302 EVSS 1305
V S
Sbjct: 893 CVGS 896
Score = 115 bits (288), Expect = 6e-25
Identities = 188/970 (19%), Positives = 398/970 (41%), Gaps = 169/970 (17%)
Query: 589 LKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSI 648
L P E ++ L+E K F + + + KK K H
Sbjct: 7 LPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINH----------GT 56
Query: 649 SQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHD---RDHFKKEEKLSKMKL 705
+ E + ED++Q ++A L E ++ + L+ + +DH + K +L
Sbjct: 57 NPETTTSGGCHSPEDTQQ--NRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTEL 114
Query: 706 EEKEWLFKDEKSLKRIKDTNKD--------ISRSFR--------------EEKDRSNK-- 741
E L+ + + ++ +D N +S++FR E KD + +
Sbjct: 115 ETA--LYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLH 172
Query: 742 ------AEKERSLKEKSPKEEKLRLYKEERKKKSKDRPS-----------KLEKKNDLKE 784
E +R+L S + +K Y EE K+ +D S +L+KKN +
Sbjct: 173 HSWHFAGELQRALSAVSTRHKKADRYIEELTKE-RDALSLELYRNTITNEELKKKNAELQ 231
Query: 785 DKI---SKEKEKI---FKEDKEKLKKEKVY----REDSAFDEYCNKNQFLENEDTKFSLS 834
+K+ EK +I KE K KL++ K + ++ +E + + L ++ K
Sbjct: 232 EKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 291
Query: 835 DDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRA 894
+++ R L + + ++ + + + + + ++E KE R
Sbjct: 292 EEKMWRQEERLREQEGKMREQEE--------KMWRQEKRLREQEKELREQEKELREQKEL 343
Query: 895 REKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDA 954
RE+ + + + + + + EK +EQ EK L E++K+ RE + RD+++
Sbjct: 344 REQEEQMQ-----EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Query: 955 LESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDG 1014
+ ER + EE RE+ K WE+ RE++K
Sbjct: 399 MWEQDERL---REKEERMREQEKM---------------------WEQVEKMREEKKMQ- 433
Query: 1015 PDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDK 1074
++E+K + + E+ +E E+ I E+ +K +E ++ +E+++ +K ++ + +
Sbjct: 434 -EQEKKTRDQEEKMQE--------EERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
Query: 1075 ERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESED-DRDSCMGS 1133
E++ + E+KEK + E++ ++ +EK W + D+ E ++ M
Sbjct: 485 EKEWQQQRLPEQKEKLW---------EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 1134 GFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADA 1193
KM E D + +++ ++ + + + ++ ++ D+E + R ++R
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 1194 GRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
+ ++E+ + +E+K +E EK ++++++ + ++ ++K+ E+ EK E+K
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
Query: 1254 SKHK--EKSDK--EHSKERKSSRSADAEKSLLEK--------------------LEEEAL 1289
+ + E+ +K EH K ++ + + E+ + E+ EEE++
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 1290 HEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEP----PGDDKPRESACLPEKLK 1345
E + ++ + + QE + E + + ++K E LPE+ K
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ-K 774
Query: 1346 EKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVS 1405
EK +K ++E +++ EK E+ G K GQ EK +G
Sbjct: 775 EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK------MWGQE 828
Query: 1406 YNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKH 1465
M E + +++ E+K + + + K E+E K G +E+K RE+
Sbjct: 829 EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG-------QEEKMREQ- 880
Query: 1466 REKWRDEKER 1475
EK R ++E+
Sbjct: 881 EEKMRGQEEK 890
Score = 105 bits (263), Expect = 5e-22
Identities = 131/667 (19%), Positives = 297/667 (44%), Gaps = 100/667 (14%)
Query: 998 EPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFK 1057
E W + RE+EKK RK++ K R +E+ +++ + EK + ++ + +
Sbjct: 273 EMWRQEEELREQEKKI-----RKQEEKMWRQEERLREQEGKMREQEEKMWRQEK--RLRE 325
Query: 1058 EKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDK--KGKEKSWYI 1115
++K+ +E+ K+ + KE + +Q +E++EK + E+ ++++K + +E+ W
Sbjct: 326 QEKELREQEKELR-EQKELREQEEQMQEQEEKMWE---QEEKMREQEEKMWRQEERLWEQ 381
Query: 1116 ADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPER 1175
++ + RD E + + L+EKEE R ++ +Q +
Sbjct: 382 EKQMREQEQKMRDQ---------EERMWEQDERLREKEERM------REQEKMWEQVEKM 426
Query: 1176 QKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNK 1235
+++K+ +++ K + ++E++ E+ K+ +++E T + ++ K + ++ +++ K
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 1236 ----QKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHE 1291
Q+LPE+ EK E + + K +E ++++ + + EK+ E+
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 1292 YREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHR 1351
+ ++ + E +R E ++ +++ EK++E+ER R
Sbjct: 547 WEQEEKMRDQEQKMWDQEER--------------MEKKTQEQEKKTWDQEEKMREEERMR 592
Query: 1352 HSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKAD 1411
KK + E +E+ EK ++ E+ + K Q EK + + +
Sbjct: 593 ERE---KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 1412 IEDEL-------DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREK 1464
E+++ ++ +L+ EK + + +E +KI ++ K EKK +E+
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK----------MEKKTQEQ 699
Query: 1465 HREKWRDEKERHRD--RHADGLLRHHRDELLRHHRD---EQKPATRDKDSPPRVLKDKSR 1519
++ W EK R + R + +R +E++R + EQ+ ++++ ++K
Sbjct: 700 EKKTWDQEKMREEESMREREKKMR-EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
Query: 1520 D------EGPRLGDAKLK-----------------EKFKDGAEKEKGDPVKMSNGNDKVA 1556
+ E RL + K K EK +D EK +G KM +K+
Sbjct: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Query: 1557 PSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSG 1616
++ K EK+ G + M E+M Q++ ++EE+ + +E+M++ E+ + R
Sbjct: 819 GQEE---KMWGQEEKMWGQEEKMWGQEEKMWGQEE-KMEEKMQGQEEKMREQEE-KMRGQ 873
Query: 1617 DPKLKEK 1623
+ K++E+
Sbjct: 874 EEKMREQ 880
Score = 63.9 bits (154), Expect = 2e-09
Identities = 84/483 (17%), Positives = 208/483 (43%), Gaps = 29/483 (6%)
Query: 1198 KEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK 1257
+E+++ + +E +++E +K + ++++ + ++ + K+ E+ EK E + + + K
Sbjct: 271 QEEMWRQEEELREQE--KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEK 328
Query: 1258 EKSDKEHSKERKSSRSADAEKSLLEKLE------EEALHEYREDSNDKISEVSSDSFTDR 1311
E +E KE + + ++ +++ E EE + E E + + R
Sbjct: 329 EL--REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 1312 GQEPGLTAFLEVSFTEP----PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAK 1367
QE + E + + +++ RE + E++++ + KK+ D+E
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 1368 KEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
+E+ +E+ + +E + + E+ + + K + L + E ++
Sbjct: 447 QEEERIREREKKMRE--EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Query: 1428 KDKNDSER--EPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLL 1485
K + E+ E +KI + + +G + +++K RE+ + W +++E+ RD+
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEK-KMWRQEKMREQEDQMW-EQEEKMRDQEQK--- 559
Query: 1486 RHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDP 1545
++E + EQ+ T D++ R +++ R+ ++ + +E ++ EK +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREE--EEMMREQEEKMQEQE 616
Query: 1546 VKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERM 1605
KM +K+ ++ K EK+ + M E+M Q+ L ++ E+M
Sbjct: 617 EKMQEQEEKMWEQEE---KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 1606 KQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAE 1665
++ EK++ + +EK + ++K K ++KK++E + E
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 1666 NKL 1668
K+
Sbjct: 734 EKM 736
Score = 53.9 bits (128), Expect = 2e-06
Identities = 88/456 (19%), Positives = 192/456 (42%), Gaps = 50/456 (10%)
Query: 1203 EKHKEKKDKESTEKYKDRKD-------RASVDSTQDKKNKQKLPEKAEKK--HAAEDKAK 1253
EK ++ K E+ +K+ D + + D+ + K N PE H+ ED +
Sbjct: 15 EKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQQ 74
Query: 1254 SKHKEKSDKEHSKERKSS--RSADAEKSLL-----EKLEEEALHEYREDSNDKISEVSSD 1306
++ + K +K+ S + + + R +A+ + +K E E Y +D+ K +
Sbjct: 75 NRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFED---- 130
Query: 1307 SFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERA 1366
+ G L +F P ++ +P + K+ H S + + +RA
Sbjct: 131 --GNLGTPSSFNLALSQAFRGSPLGCV--STSLIPGESKDLAGRLHHSWHF--AGELQRA 184
Query: 1367 KKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTE 1426
+ + +K + Y E ++ E+D L + Y + E+ K EL E
Sbjct: 185 LSAVSTRHKKADRYIEELTK------ERDALSLELYRNTITN----EELKKKNAEL--QE 232
Query: 1427 KKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLR 1486
K +SE+ + KELK A +L + + E WR E+E R + +R
Sbjct: 233 KLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL---REQEKKIR 289
Query: 1487 HHRDELLRHHR--DEQKPATRDKDS----PPRVLKDKSRDEGPRLGDAKLKEKFKDGAEK 1540
+++ R EQ+ R+++ + L+++ ++ + + + +++ ++ E+
Sbjct: 290 KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQ 349
Query: 1541 EKGDPVKMSNGNDKVAPSKDP-GKKDAR--PREKLLGDGDLMMTSFERMLSQKDLEIEER 1597
+ KM +K+ ++ +++ R +EK + + + M E + ++D + E+
Sbjct: 350 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
Query: 1598 HKRHKERMKQMEKLRHRSGDPKLKEKAKPADDGRKK 1633
+R +E+ K E++ + K++E+ K D +K
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 116 bits (290), Expect = 3e-25
Identities = 266/1294 (20%), Positives = 482/1294 (37%), Gaps = 196/1294 (15%)
Query: 448 QKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDR--DSLGSSGCLKGS 505
Q+ K K+K +K K E + +F S ++ S+ +GE+ + DS S S
Sbjct: 254 QQNKKKIKVDSEKSNKVYE-----HTSRF--SPKKTSSNCNGEEKKLDDSCSGSVTYSYS 306
Query: 506 PLV-----LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWS 560
L+ +K +A+ SS+ Q + S TK + +K++
Sbjct: 307 ALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV------ 360
Query: 561 EVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVP 620
L+D + L E D +SE +++++ + +EH+ + E K+ A+
Sbjct: 361 ----LADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKAR-KGEKPCALE 415
Query: 621 KLD---KEGKVVKKH-KTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLEN 676
K D E K+ +K ++H H+N ++ KS E++ S +K + N
Sbjct: 416 KKDISKSEAKLSRKQVDSEHMHQN-----VPTEEQRTNKSTGGEHKKSDRKEEPQYEPAN 470
Query: 677 DLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEK 736
T L D D + + E E + + S+ D + +
Sbjct: 471 ---TSEDL-----DMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSS 522
Query: 737 DRSNKAEKER--SLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKI------- 787
+ N + K+ +K K+ + LY + + P K ++ +DK
Sbjct: 523 VKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGL 582
Query: 788 ------------SKEKEKIFKEDKEKLKKEKVYRED------------------SAFDEY 817
+ + E + + + L +E R S DE
Sbjct: 583 NPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEE 642
Query: 818 CNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF-KGEDSWDSPVTDYRDMKSDSVAKL 876
CN+ E K S+ ++D+ S SDS+ D K S ++ D SDS L
Sbjct: 643 CNETV---KEKQKLSVPVRKKDKRNS--SDSAIDNPKPNKLPKSKQSETVDQNSDSDEML 697
Query: 877 -ILETVKEDSKERRRDSRARE-KRDYREPFFRKKDRDYLDKNSEKRKEQT-------EKH 927
IL+ V S D+ E +++ + K DK KRK T +K
Sbjct: 698 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 757
Query: 928 KSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKD 987
KS + K K++ +S + D + E + G A+ + K+ K
Sbjct: 758 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 817
Query: 988 KSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQ 1047
G +G H + ++ D ERK++ + E + DKD + + ++
Sbjct: 818 SKKGMDNQG------HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 871
Query: 1048 KDKE-------FDKC---------FKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAF 1091
K ++ DK + +K + K K H K K K D + EK
Sbjct: 872 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 931
Query: 1092 PGIISEDFSE--KKDDKKGKEKSWYIADIFTD--ESEDDRDSCMGSGFKMGEASDLPR-T 1146
S++ SE KK KKG E+ +D + E +S K+ E ++
Sbjct: 932 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 991
Query: 1147 DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRG-AADAGRDKKEKVFEKH 1205
G+++ + G + +K DK ++ + + ++ +G + D+ DKK K
Sbjct: 992 KGIKQIKNGTTD-GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050
Query: 1206 KEKK---------------DKESTEKYKDRKD----------------RASVDSTQDKKN 1234
+EKK TEKY ++D R ++ S ++ K
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1110
Query: 1235 KQKLPEKAEKKHAAEDKAKSKHKEKSDKEHS--KERKSSRSADAEKSLLEKLEEEALHEY 1292
Q ++ + ++ED K K + S K+ KE+K + + K + + +
Sbjct: 1111 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1170
Query: 1293 REDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRH 1352
+D + I E SSD + L F + GD+ +S +P + + +
Sbjct: 1171 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS--VPVTVDDDDDDND 1228
Query: 1353 SSSSSKKSHDRERAKKEKAEKKE-KGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKAD 1411
+ K E K + ++ +D E G ++ Q E++ + +A N ++D
Sbjct: 1229 PENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKN-QVNSESD 1287
Query: 1412 IEDELDKTIELFSTEKKDK-NDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWR 1470
+ E K + K S+ E + EK+ KP + K+ + ++R K
Sbjct: 1288 SDSEESKKPRYRHRLLRHKLTVSDGESGE--EKKTKPK--------EHKEVKGRNRRKVS 1337
Query: 1471 DEKERHRDRHADGLLRHHRDELLRHHRDEQKPATR-----DKDSPPRVLKDKSR------ 1519
E D G+ E + DEQ+P TR + + R K K +
Sbjct: 1338 SEDSEDSDFQESGV-----SEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKV 1392
Query: 1520 -DEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDL 1578
++ + +E+ ++ E+E+ + + D+ SK PGK + R K+L D D
Sbjct: 1393 QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR-KILKD-DK 1450
Query: 1579 MMTSFERMLSQKDLEIEERHKRHKERMKQMEKLR 1612
+ T + L ++ EER KR ER ++ EKLR
Sbjct: 1451 LRTETQNALKEE----EERRKRIAEREREREKLR 1480
Score = 98.2 bits (243), Expect = 9e-20
Identities = 197/972 (20%), Positives = 370/972 (38%), Gaps = 130/972 (13%)
Query: 336 PQKATAPVKDEYEFD---EDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYT 392
P+ T P++ E + + +++ V +K L RK+ K NS S
Sbjct: 619 PRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDS-----AIDNP 673
Query: 393 KNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSA-----HTILPGSKTREPSNAKQ 447
K N + K S + ++ +E ++ S+ + I KT +
Sbjct: 674 KPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQA 733
Query: 448 QKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPL 507
K+ +K K+KRK T G + F + K S S+ + + + S
Sbjct: 734 GKD-DKGKRKRKSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSE-------- 782
Query: 508 VLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSD 567
+ K+ S + A+ T+ + + S ++H+K DN + E SS D
Sbjct: 783 LEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM-DNQGHKNLKTSQEGSS--D 839
Query: 568 STRTRLTSESDYSSEGSSVE--SLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKE 625
+ E+ S+EG+ + ++ +R R +++AS S LS E + L+
Sbjct: 840 DAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVR 899
Query: 626 GKVVKKHKTKHKH----KNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTE 681
K K+KH K + G I+++ K + E + +K K E ++
Sbjct: 900 KVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSD 959
Query: 682 NKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNK 741
K KV+K ++ + + K L E+E + K +K+IK+ D + ++ +D+++K
Sbjct: 960 FKKKVIKMEQQYESSSDGTEK--LPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK 1017
Query: 742 AEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEK 801
K+++L Y E+ K S +KK+ K +EK++ K
Sbjct: 1018 ------------KKDELSDYAEKSTGKGDSCDSSEDKKS--KNGAYGREKKRCKLLGKSS 1063
Query: 802 LKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSP 861
K++ D+ ++Y K + D + + + R S ++ G S D+
Sbjct: 1064 RKRQDCSSSDT--EKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1121
Query: 862 VT--DYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS-- 917
+ D + K + +K VKE + R S R++ D + D D+NS
Sbjct: 1122 ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDD--DQNSIG 1179
Query: 918 -EKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREEL 976
EQ K + LS + S + + + + D + A + L
Sbjct: 1180 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1239
Query: 977 KECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
+E SD D EP E ++ +++ D+E K + E + K
Sbjct: 1240 EEIKANLS----SDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKK 1295
Query: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIIS 1096
+ L + + + +EKK ++HK+ G+++ + +S D S
Sbjct: 1296 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED--------------S 1341
Query: 1097 EDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQ--EKEE 1154
ED S+ ++ +E S ESED++ PRT + E EE
Sbjct: 1342 ED-SDFQESGVSEEVS---------ESEDEQR---------------PRTRSAKKAELEE 1376
Query: 1155 GREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKEST 1214
+ +Y K+ + RR+ + D+ + K E+ +EK+++E
Sbjct: 1377 NQRSY-------------------KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE 1417
Query: 1215 EKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSA 1274
E+ ++ ++ +D+ + K P K KK K E + +E + R A
Sbjct: 1418 EEEEEEEE-------EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIA 1470
Query: 1275 DAEKSLLEKLEE 1286
+ E+ EKL E
Sbjct: 1471 ERERE-REKLRE 1481
Score = 95.9 bits (237), Expect = 5e-19
Identities = 190/896 (21%), Positives = 341/896 (38%), Gaps = 124/896 (13%)
Query: 647 SISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLE 706
++ ++ KL S +D + SD AI D NKL K + + +
Sbjct: 646 TVKEKQKL-SVPVRKKDKRNSSDSAI----DNPKPNKLPKSKQSETVDQNSDS------D 694
Query: 707 EKEWLFKDEKSLKRIKDTNKDIS------RSFREEKDRSNKAEKERSLKEKSPKEEKLRL 760
E + K+ + ++ DI+ ++ + K ++ K +K + ++ S
Sbjct: 695 EMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDT 754
Query: 761 YKEERKKKS----KDRPSKLEKKN---DLKEDKISKEKEKIFKEDKEKLKKEKVYREDSA 813
K + K S K R ++ E N +L+++ S K + K+++ K + DS+
Sbjct: 755 KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSS 812
Query: 814 FDEYCNK----NQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDM- 868
DE +K NQ +N T S D +R + SS + G D+ + + RD
Sbjct: 813 EDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--GTVDKDTTIMELRDRL 870
Query: 869 --------KSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK- 919
+D V KL + S E R+ + +EK + + KK +D L +EK
Sbjct: 871 PKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKF 930
Query: 920 -RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKE 978
+K+Q+++ SE DKK+ K+ + + KP + ++ +K
Sbjct: 931 LKKDQSDE-------TSEDDKKQS----------------KKGTEEKKKPSDFKKKVIK- 966
Query: 979 CGCESGFKDKSDGD-----------FGKGLEPWERHHPAREKEKKDGPDKERKEKTKPER 1027
E ++ SDG F KG++ + EK+ K DK K+K +
Sbjct: 967 --MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSD 1024
Query: 1028 YKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKK---DTKEKHKDTHGKDKERKASLDQGK 1084
Y EKS+ K S S +K K+ + + K K + K +D D E+ + + G
Sbjct: 1025 YAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGC 1084
Query: 1085 EKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLP 1144
+K I + + KE + +ES +D K +
Sbjct: 1085 NSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDN--------KKKKQRTSS 1136
Query: 1145 RTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEK 1204
+ + KE+ R + + RK +D ++ D + G + K + V E
Sbjct: 1137 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED--DDQNSIGEGSSDEQKIKPVTEN 1194
Query: 1205 HKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEH 1264
+ D SV T D + PE K ++ K+ D
Sbjct: 1195 LVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSS 1254
Query: 1265 SKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVS 1324
E + + +++ +EEA ++ +S+ E + R LT S
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314
Query: 1325 FTEPPGDDKPRESACLPEKLKEKERHRHSSSSSK--------------KSHDRERAKK-- 1368
E KP+E +++K + R + SS S+ +S D +R +
Sbjct: 1315 GEEKK--TKPKEH----KEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368
Query: 1369 -EKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
+KAE +E YK+ R+ E E + + + E+E ++ E E+
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE---EEE 1425
Query: 1428 KDKNDSEREPSK---KIEKELKP--YGSSAINILKEKKKREKHREKWRDEKERHRD 1478
+D+ND + P K KI K LK + N LKE+++R K + E+E+ R+
Sbjct: 1426 EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1481
Score = 87.0 bits (214), Expect = 2e-16
Identities = 194/929 (20%), Positives = 349/929 (37%), Gaps = 168/929 (18%)
Query: 449 KEKNK----VKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKG 504
KEK K V+KK K+ + + K + S +SE+ S D+
Sbjct: 648 KEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDE------------ 695
Query: 505 SPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSS 564
+ + L S SH SS+ N HT+ T + + KT +
Sbjct: 696 ---------MLAILKEVSRMSHSSSSDTDINEIHTNHKTLY----DLKTQAGK-----DD 737
Query: 565 LSDSTRTRLTSESDYS-----SEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
R TS SD+ S SS+ S K + + E S EK+ +S GA
Sbjct: 738 KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKI-GAA 796
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
K K + K+ +KG + + S +D+++K ++ +
Sbjct: 797 RTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE-G 855
Query: 680 TENKLKVLKHDRDHFKKEEKLSKM-----KLEEKEWLFKD-----------------EKS 717
T +K + RD K+++ S KL KE F K+
Sbjct: 856 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 915
Query: 718 LKRIKDTNKDISRSF--REEKDRSNKAEKERSLK----EKSPKEEKLRLYK-EERKKKSK 770
K+++D DI+ F +++ D +++ +K++S K +K P + K ++ K E++ + S
Sbjct: 916 CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSS 975
Query: 771 DRPSKLEKKNDL-------KEDKI-SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ 822
D KL ++ ++ K+ K + + EK K+ ++K K+K D A +
Sbjct: 976 DGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDS 1035
Query: 823 FLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVK 882
+ED K R++ L S K +D S Y MK D +
Sbjct: 1036 CDSSEDKKSKNGAYGREKKRCKLLGKS-SRKRQDCSSSDTEKY-SMKEDGCNSSDKRLKR 1093
Query: 883 EDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKR- 941
+ +ERR S R ++ + + + N +K++ + K K+V K+KKR
Sbjct: 1094 IELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAV----IVKEKKRN 1149
Query: 942 -------RESAEAGRDRKDALESCKERRDGRAKPEEAHREELKE---CGCESGFKDKSDG 991
R+ A+ +E + G +E + + E +GF S
Sbjct: 1150 SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS-- 1207
Query: 992 DFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKE 1051
G E + P + D D E + ++K +LE+ + +
Sbjct: 1208 ----GDEALSKSVPVTVDDDDDDNDPENRI----------------AKKMLLEEIKANLS 1247
Query: 1052 FDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK 1111
D+ + +E K T GK E ++ K + + SE S+ ++ KK + +
Sbjct: 1248 SDEDGSSDDEPEEGKKRT-GKQNEENPGDEEAKNQ-------VNSESDSDSEESKKPRYR 1299
Query: 1112 SWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKE-EGREAY-ASDRHRKSSD 1169
+ T GE+ + +T + KE +GR S + SD
Sbjct: 1300 HRLLRHKLTVSD--------------GESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1345
Query: 1170 KQHP---ERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASV 1226
Q E + E R + R A KK ++ E + K K+ + K ++D
Sbjct: 1346 FQESGVSEEVSESEDEQRPRTRSA------KKAELEENQRSYKQKKKRRRIKVQED---- 1395
Query: 1227 DSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE----RKSSRS--------A 1274
S+++K N ++ E+ EK+ E++ + + +E+ + + SK RK R
Sbjct: 1396 SSSENKSNSEE--EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRT 1453
Query: 1275 DAEKSLLEKLEEEALHEYREDSNDKISEV 1303
+ + +L E+ E RE +K+ EV
Sbjct: 1454 ETQNALKEEEERRKRIAEREREREKLREV 1482
Score = 81.6 bits (200), Expect = 9e-15
Identities = 173/848 (20%), Positives = 314/848 (37%), Gaps = 137/848 (16%)
Query: 294 ESSTESSEEEDAPSFAPSSSV----------DGNNTDSEFEKGLKHKAKNPEPQKATAPV 343
+SST S+ + + SS+ + +N DSE EK +K +K + +
Sbjct: 744 KSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRI 803
Query: 344 KDEYEFD-EDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKA 402
+ +FD +DE+ +D++ K+ + + +S + K E ++++ K
Sbjct: 804 PNTKDFDSSEDEKHSKKGMDNQG--HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 861
Query: 403 SHRILSD-TSDEEDASVTVGTGEKL--RLSAHTILPGSKTREPSNAKQQKEKNKVKKKRK 459
+ L D ++ AS + +KL + + T L K E + K + K K KK +
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE-TKEKSKHLKTKTCKKVQ 920
Query: 460 KETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLS 519
+F K+ +SE + + S+ G +++ K PS F
Sbjct: 921 DGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK----------------KKPSDFKKKV 964
Query: 520 ASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDY 579
+ SS+ T P E+ + +D
Sbjct: 965 IKMEQQYESSSD--------------------GTEKLPEREEICHFPKGIKQIKNGTTDG 1004
Query: 580 SSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHK 639
+ + K +K+ E A S K S+E K G+ K+ K K
Sbjct: 1005 EKKSKKIRD-KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063
Query: 640 NKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEK 699
K + CS S K ED SDK +
Sbjct: 1064 RKRQ-DCSSSDTEKYSM----KEDGCNSSDK----------------------------R 1090
Query: 700 LSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSP---KEE 756
L +++L E+ ++ S + K+ S S EE NK +K+R+ +K KE+
Sbjct: 1091 LKRIELRER----RNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEK 1146
Query: 757 KLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYRE------ 810
K + K+K D S +D+++D + E E K K E +
Sbjct: 1147 KRNSLRTSTKRKQADITS--SSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFC 1204
Query: 811 DSAFDEYCNKNQFL-----------ENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWD 859
S+ DE +K+ + EN K L ++ + SD D S D + E+
Sbjct: 1205 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD-EDGSSDDEPEEGKK 1263
Query: 860 SPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
+ D AK + + E DS +K YR R K ++ E+
Sbjct: 1264 RTGKQNEENPGDEEAK------NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1317
Query: 920 RKEQTEKHKSVPG----YLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREE 975
+K + ++HK V G +S +D + + E+G E + + R + A + E
Sbjct: 1318 KKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE----EVSESEDEQRPRTRSAKKAE 1373
Query: 976 LKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDK 1035
L+E + +K K K E + + +E+++ ++E +E+ + E +E +D
Sbjct: 1374 LEE--NQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1431
Query: 1036 DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGII 1095
KS +K +K + DK E ++ + +++ER+ + + + ++EK I
Sbjct: 1432 SKSPGKGRKKIRKILKDDKLRTETQNALK-------EEEERRKRIAEREREREKLREVIE 1484
Query: 1096 SEDFSEKK 1103
ED S K
Sbjct: 1485 IEDASPTK 1492
Score = 77.8 bits (190), Expect = 1e-13
Identities = 121/544 (22%), Positives = 221/544 (40%), Gaps = 74/544 (13%)
Query: 289 YTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDE-- 346
Y SS + + + E E+ F N T +K K + K T+ KDE
Sbjct: 971 YESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDK-------TSKKKDELS 1023
Query: 347 -YEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHR 405
Y + D +DK Y +E K + + + + ++T K +
Sbjct: 1024 DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT--EKYSMKE 1081
Query: 406 ILSDTSDEEDASVTVGTGEKLRLSAHT--ILPGSKTREPSNAKQQKEKNKVKKKRKKETK 463
++SD+ + + L +T I GS + S+A++ E NK KK+R K
Sbjct: 1082 DGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSS---SDAEESSEDNKKKKQRTSSKK 1138
Query: 464 GREVRFGKRSDKFCSSE-------SESESSESGEDDRDSLG--SSGCLKGSPLVLKDPSL 514
+ K+ + +S + S SS+ +DD++S+G SS K P+ +L
Sbjct: 1139 KAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVT---ENL 1195
Query: 515 FSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLT 574
S S G A K P D +N I+ L + + L+
Sbjct: 1196 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN--RIAK------KMLLEEIKANLS 1247
Query: 575 SESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV-PKLDKEGKVVKKHK 633
S+ D SS+ +E +KR +++P A+ V + D + + KK +
Sbjct: 1248 SDEDGSSDDEP----------EEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPR 1297
Query: 634 TKHK---HK-NKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKH 689
+H+ HK G+ ++ K K E+++ K ++ + + E+ ++ + +
Sbjct: 1298 YRHRLLRHKLTVSDGESGEEKKTKPK----EHKEVKGRNRRKVSSEDSEDSDFQESGVSE 1353
Query: 690 DRDHFKKEEK-----LSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEK 744
+ + E++ K +LEE + +K +K +RIK +E+ NK+
Sbjct: 1354 EVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIK---------VQEDSSSENKSNS 1404
Query: 745 ERSLKEKSPKEEKLRLYKEERKKKSKD--RPSKLEKK--NDLKEDKISKEKEKIFKEDKE 800
E +EK +EE+ +EE + ++ D P K KK LK+DK+ E + KE++E
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Query: 801 KLKK 804
+ K+
Sbjct: 1465 RRKR 1468
Score = 67.4 bits (163), Expect = 2e-10
Identities = 135/574 (23%), Positives = 233/574 (40%), Gaps = 77/574 (13%)
Query: 291 SSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKN--PEPQKATAPVKDEYE 348
S +E S S E S T + + GL A+ + Q D+ +
Sbjct: 887 SGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQ 946
Query: 349 FDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSY-------TKNNTIAPKK 401
+ E+ + P K ++K + + E+ S+ +P+ E + KN T +K
Sbjct: 947 SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEK 1006
Query: 402 ASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKE 461
S +I TS ++D LS + K +++ +K KN + KK
Sbjct: 1007 KSKKIRDKTSKKKD-----------ELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1055
Query: 462 TKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSAS 521
K KR D CSS S++E ED +S S LK + L++ SS +
Sbjct: 1056 CKLLGKSSRKRQD--CSS-SDTEKYSMKEDGCNS--SDKRLKR--IELRERRNLSSKRNT 1108
Query: 522 STSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTR---LTSES- 577
GSS++ + S D K RT + K + +SL ST+ + +TS S
Sbjct: 1109 KEIQSGSSSSDAEESSE-DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSS 1167
Query: 578 ------DYSS--EGSSVES-LKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKL------ 622
D +S EGSS E +KPV + LS SS + A+ K
Sbjct: 1168 SDIEDDDQNSIGEGSSDEQKIKPVTEN------LVLSSHTGFCQSSGDEALSKSVPVTVD 1221
Query: 623 ------DKEGKVVKK---HKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSK--QKSDKA 671
D E ++ KK + K + E G E K + E++ +++
Sbjct: 1222 DDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQ 1281
Query: 672 ILLENDLSTENKLK------VLKHD---RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIK 722
+ E+D +E K +L+H D EEK +K K E KE ++ + +
Sbjct: 1282 VNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK-EHKEVKGRNRRKVSSED 1340
Query: 723 DTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDL 782
+ D S E+ +++E E+ + +S K+ +L + K+K K R K+++ +
Sbjct: 1341 SEDSDFQESGVSEE--VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS- 1397
Query: 783 KEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDE 816
E+K + E+E+ KE++E+ ++E+ E+ D+
Sbjct: 1398 SENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1431
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 116 bits (290), Expect = 3e-25
Identities = 266/1294 (20%), Positives = 482/1294 (37%), Gaps = 196/1294 (15%)
Query: 448 QKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDR--DSLGSSGCLKGS 505
Q+ K K+K +K K E + +F S ++ S+ +GE+ + DS S S
Sbjct: 292 QQNKKKIKVDSEKSNKVYE-----HTSRF--SPKKTSSNCNGEEKKLDDSCSGSVTYSYS 344
Query: 506 PLV-----LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWS 560
L+ +K +A+ SS+ Q + S TK + +K++
Sbjct: 345 ALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV------ 398
Query: 561 EVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVP 620
L+D + L E D +SE +++++ + +EH+ + E K+ A+
Sbjct: 399 ----LADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKAR-KGEKPCALE 453
Query: 621 KLD---KEGKVVKKH-KTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLEN 676
K D E K+ +K ++H H+N ++ KS E++ S +K + N
Sbjct: 454 KKDISKSEAKLSRKQVDSEHMHQN-----VPTEEQRTNKSTGGEHKKSDRKEEPQYEPAN 508
Query: 677 DLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEK 736
T L D D + + E E + + S+ D + +
Sbjct: 509 ---TSEDL-----DMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSS 560
Query: 737 DRSNKAEKER--SLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKI------- 787
+ N + K+ +K K+ + LY + + P K ++ +DK
Sbjct: 561 VKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGL 620
Query: 788 ------------SKEKEKIFKEDKEKLKKEKVYRED------------------SAFDEY 817
+ + E + + + L +E R S DE
Sbjct: 621 NPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEE 680
Query: 818 CNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF-KGEDSWDSPVTDYRDMKSDSVAKL 876
CN+ E K S+ ++D+ S SDS+ D K S ++ D SDS L
Sbjct: 681 CNETV---KEKQKLSVPVRKKDKRNS--SDSAIDNPKPNKLPKSKQSETVDQNSDSDEML 735
Query: 877 -ILETVKEDSKERRRDSRARE-KRDYREPFFRKKDRDYLDKNSEKRKEQT-------EKH 927
IL+ V S D+ E +++ + K DK KRK T +K
Sbjct: 736 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 795
Query: 928 KSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKD 987
KS + K K++ +S + D + E + G A+ + K+ K
Sbjct: 796 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 855
Query: 988 KSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQ 1047
G +G H + ++ D ERK++ + E + DKD + + ++
Sbjct: 856 SKKGMDNQG------HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 909
Query: 1048 KDKE-------FDKC---------FKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAF 1091
K ++ DK + +K + K K H K K K D + EK
Sbjct: 910 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 969
Query: 1092 PGIISEDFSE--KKDDKKGKEKSWYIADIFTD--ESEDDRDSCMGSGFKMGEASDLPR-T 1146
S++ SE KK KKG E+ +D + E +S K+ E ++
Sbjct: 970 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 1029
Query: 1147 DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRG-AADAGRDKKEKVFEKH 1205
G+++ + G + +K DK ++ + + ++ +G + D+ DKK K
Sbjct: 1030 KGIKQIKNGTTD-GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088
Query: 1206 KEKK---------------DKESTEKYKDRKD----------------RASVDSTQDKKN 1234
+EKK TEKY ++D R ++ S ++ K
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1148
Query: 1235 KQKLPEKAEKKHAAEDKAKSKHKEKSDKEHS--KERKSSRSADAEKSLLEKLEEEALHEY 1292
Q ++ + ++ED K K + S K+ KE+K + + K + + +
Sbjct: 1149 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1208
Query: 1293 REDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRH 1352
+D + I E SSD + L F + GD+ +S +P + + +
Sbjct: 1209 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS--VPVTVDDDDDDND 1266
Query: 1353 SSSSSKKSHDRERAKKEKAEKKE-KGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKAD 1411
+ K E K + ++ +D E G ++ Q E++ + +A N ++D
Sbjct: 1267 PENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKN-QVNSESD 1325
Query: 1412 IEDELDKTIELFSTEKKDK-NDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWR 1470
+ E K + K S+ E + EK+ KP + K+ + ++R K
Sbjct: 1326 SDSEESKKPRYRHRLLRHKLTVSDGESGE--EKKTKPK--------EHKEVKGRNRRKVS 1375
Query: 1471 DEKERHRDRHADGLLRHHRDELLRHHRDEQKPATR-----DKDSPPRVLKDKSR------ 1519
E D G+ E + DEQ+P TR + + R K K +
Sbjct: 1376 SEDSEDSDFQESGV-----SEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKV 1430
Query: 1520 -DEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDL 1578
++ + +E+ ++ E+E+ + + D+ SK PGK + R K+L D D
Sbjct: 1431 QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR-KILKD-DK 1488
Query: 1579 MMTSFERMLSQKDLEIEERHKRHKERMKQMEKLR 1612
+ T + L ++ EER KR ER ++ EKLR
Sbjct: 1489 LRTETQNALKEE----EERRKRIAEREREREKLR 1518
Score = 98.2 bits (243), Expect = 9e-20
Identities = 197/972 (20%), Positives = 370/972 (38%), Gaps = 130/972 (13%)
Query: 336 PQKATAPVKDEYEFD---EDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYT 392
P+ T P++ E + + +++ V +K L RK+ K NS S
Sbjct: 657 PRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDS-----AIDNP 711
Query: 393 KNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSA-----HTILPGSKTREPSNAKQ 447
K N + K S + ++ +E ++ S+ + I KT +
Sbjct: 712 KPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQA 771
Query: 448 QKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPL 507
K+ +K K+KRK T G + F + K S S+ + + + S
Sbjct: 772 GKD-DKGKRKRKSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSE-------- 820
Query: 508 VLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSD 567
+ K+ S + A+ T+ + + S ++H+K DN + E SS D
Sbjct: 821 LEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM-DNQGHKNLKTSQEGSS--D 877
Query: 568 STRTRLTSESDYSSEGSSVE--SLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKE 625
+ E+ S+EG+ + ++ +R R +++AS S LS E + L+
Sbjct: 878 DAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVR 937
Query: 626 GKVVKKHKTKHKH----KNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTE 681
K K+KH K + G I+++ K + E + +K K E ++
Sbjct: 938 KVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSD 997
Query: 682 NKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNK 741
K KV+K ++ + + K L E+E + K +K+IK+ D + ++ +D+++K
Sbjct: 998 FKKKVIKMEQQYESSSDGTEK--LPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK 1055
Query: 742 AEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEK 801
K+++L Y E+ K S +KK+ K +EK++ K
Sbjct: 1056 ------------KKDELSDYAEKSTGKGDSCDSSEDKKS--KNGAYGREKKRCKLLGKSS 1101
Query: 802 LKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSP 861
K++ D+ ++Y K + D + + + R S ++ G S D+
Sbjct: 1102 RKRQDCSSSDT--EKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1159
Query: 862 VT--DYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS-- 917
+ D + K + +K VKE + R S R++ D + D D+NS
Sbjct: 1160 ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDD--DQNSIG 1217
Query: 918 -EKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREEL 976
EQ K + LS + S + + + + D + A + L
Sbjct: 1218 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1277
Query: 977 KECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
+E SD D EP E ++ +++ D+E K + E + K
Sbjct: 1278 EEIKANLS----SDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKK 1333
Query: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIIS 1096
+ L + + + +EKK ++HK+ G+++ + +S D S
Sbjct: 1334 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED--------------S 1379
Query: 1097 EDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQ--EKEE 1154
ED S+ ++ +E S ESED++ PRT + E EE
Sbjct: 1380 ED-SDFQESGVSEEVS---------ESEDEQR---------------PRTRSAKKAELEE 1414
Query: 1155 GREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKEST 1214
+ +Y K+ + RR+ + D+ + K E+ +EK+++E
Sbjct: 1415 NQRSY-------------------KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE 1455
Query: 1215 EKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSA 1274
E+ ++ ++ +D+ + K P K KK K E + +E + R A
Sbjct: 1456 EEEEEEEE-------EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIA 1508
Query: 1275 DAEKSLLEKLEE 1286
+ E+ EKL E
Sbjct: 1509 ERERE-REKLRE 1519
Score = 95.9 bits (237), Expect = 5e-19
Identities = 190/896 (21%), Positives = 341/896 (38%), Gaps = 124/896 (13%)
Query: 647 SISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLE 706
++ ++ KL S +D + SD AI D NKL K + + +
Sbjct: 684 TVKEKQKL-SVPVRKKDKRNSSDSAI----DNPKPNKLPKSKQSETVDQNSDS------D 732
Query: 707 EKEWLFKDEKSLKRIKDTNKDIS------RSFREEKDRSNKAEKERSLKEKSPKEEKLRL 760
E + K+ + ++ DI+ ++ + K ++ K +K + ++ S
Sbjct: 733 EMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDT 792
Query: 761 YKEERKKKS----KDRPSKLEKKN---DLKEDKISKEKEKIFKEDKEKLKKEKVYREDSA 813
K + K S K R ++ E N +L+++ S K + K+++ K + DS+
Sbjct: 793 KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSS 850
Query: 814 FDEYCNK----NQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDM- 868
DE +K NQ +N T S D +R + SS + G D+ + + RD
Sbjct: 851 EDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--GTVDKDTTIMELRDRL 908
Query: 869 --------KSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK- 919
+D V KL + S E R+ + +EK + + KK +D L +EK
Sbjct: 909 PKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKF 968
Query: 920 -RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKE 978
+K+Q+++ SE DKK+ K+ + + KP + ++ +K
Sbjct: 969 LKKDQSDE-------TSEDDKKQS----------------KKGTEEKKKPSDFKKKVIK- 1004
Query: 979 CGCESGFKDKSDGD-----------FGKGLEPWERHHPAREKEKKDGPDKERKEKTKPER 1027
E ++ SDG F KG++ + EK+ K DK K+K +
Sbjct: 1005 --MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSD 1062
Query: 1028 YKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKK---DTKEKHKDTHGKDKERKASLDQGK 1084
Y EKS+ K S S +K K+ + + K K + K +D D E+ + + G
Sbjct: 1063 YAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGC 1122
Query: 1085 EKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLP 1144
+K I + + KE + +ES +D K +
Sbjct: 1123 NSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDN--------KKKKQRTSS 1174
Query: 1145 RTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEK 1204
+ + KE+ R + + RK +D ++ D + G + K + V E
Sbjct: 1175 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED--DDQNSIGEGSSDEQKIKPVTEN 1232
Query: 1205 HKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEH 1264
+ D SV T D + PE K ++ K+ D
Sbjct: 1233 LVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSS 1292
Query: 1265 SKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVS 1324
E + + +++ +EEA ++ +S+ E + R LT S
Sbjct: 1293 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1352
Query: 1325 FTEPPGDDKPRESACLPEKLKEKERHRHSSSSSK--------------KSHDRERAKK-- 1368
E KP+E +++K + R + SS S+ +S D +R +
Sbjct: 1353 GEEKK--TKPKEH----KEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1406
Query: 1369 -EKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
+KAE +E YK+ R+ E E + + + E+E ++ E E+
Sbjct: 1407 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE---EEE 1463
Query: 1428 KDKNDSEREPSK---KIEKELKP--YGSSAINILKEKKKREKHREKWRDEKERHRD 1478
+D+ND + P K KI K LK + N LKE+++R K + E+E+ R+
Sbjct: 1464 EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1519
Score = 87.0 bits (214), Expect = 2e-16
Identities = 194/929 (20%), Positives = 349/929 (37%), Gaps = 168/929 (18%)
Query: 449 KEKNK----VKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKG 504
KEK K V+KK K+ + + K + S +SE+ S D+
Sbjct: 686 KEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDE------------ 733
Query: 505 SPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSS 564
+ + L S SH SS+ N HT+ T + + KT +
Sbjct: 734 ---------MLAILKEVSRMSHSSSSDTDINEIHTNHKTLY----DLKTQAGK-----DD 775
Query: 565 LSDSTRTRLTSESDYS-----SEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
R TS SD+ S SS+ S K + + E S EK+ +S GA
Sbjct: 776 KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKI-GAA 834
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
K K + K+ +KG + + S +D+++K ++ +
Sbjct: 835 RTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE-G 893
Query: 680 TENKLKVLKHDRDHFKKEEKLSKM-----KLEEKEWLFKD-----------------EKS 717
T +K + RD K+++ S KL KE F K+
Sbjct: 894 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 953
Query: 718 LKRIKDTNKDISRSF--REEKDRSNKAEKERSLK----EKSPKEEKLRLYK-EERKKKSK 770
K+++D DI+ F +++ D +++ +K++S K +K P + K ++ K E++ + S
Sbjct: 954 CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSS 1013
Query: 771 DRPSKLEKKNDL-------KEDKI-SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ 822
D KL ++ ++ K+ K + + EK K+ ++K K+K D A +
Sbjct: 1014 DGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDS 1073
Query: 823 FLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVK 882
+ED K R++ L S K +D S Y MK D +
Sbjct: 1074 CDSSEDKKSKNGAYGREKKRCKLLGKS-SRKRQDCSSSDTEKY-SMKEDGCNSSDKRLKR 1131
Query: 883 EDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKR- 941
+ +ERR S R ++ + + + N +K++ + K K+V K+KKR
Sbjct: 1132 IELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAV----IVKEKKRN 1187
Query: 942 -------RESAEAGRDRKDALESCKERRDGRAKPEEAHREELKE---CGCESGFKDKSDG 991
R+ A+ +E + G +E + + E +GF S
Sbjct: 1188 SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS-- 1245
Query: 992 DFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKE 1051
G E + P + D D E + ++K +LE+ + +
Sbjct: 1246 ----GDEALSKSVPVTVDDDDDDNDPENRI----------------AKKMLLEEIKANLS 1285
Query: 1052 FDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK 1111
D+ + +E K T GK E ++ K + + SE S+ ++ KK + +
Sbjct: 1286 SDEDGSSDDEPEEGKKRT-GKQNEENPGDEEAKNQ-------VNSESDSDSEESKKPRYR 1337
Query: 1112 SWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKE-EGREAY-ASDRHRKSSD 1169
+ T GE+ + +T + KE +GR S + SD
Sbjct: 1338 HRLLRHKLTVSD--------------GESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
Query: 1170 KQHP---ERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASV 1226
Q E + E R + R A KK ++ E + K K+ + K ++D
Sbjct: 1384 FQESGVSEEVSESEDEQRPRTRSA------KKAELEENQRSYKQKKKRRRIKVQED---- 1433
Query: 1227 DSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE----RKSSRS--------A 1274
S+++K N ++ E+ EK+ E++ + + +E+ + + SK RK R
Sbjct: 1434 SSSENKSNSEE--EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRT 1491
Query: 1275 DAEKSLLEKLEEEALHEYREDSNDKISEV 1303
+ + +L E+ E RE +K+ EV
Sbjct: 1492 ETQNALKEEEERRKRIAEREREREKLREV 1520
Score = 81.6 bits (200), Expect = 9e-15
Identities = 173/848 (20%), Positives = 314/848 (37%), Gaps = 137/848 (16%)
Query: 294 ESSTESSEEEDAPSFAPSSSV----------DGNNTDSEFEKGLKHKAKNPEPQKATAPV 343
+SST S+ + + SS+ + +N DSE EK +K +K + +
Sbjct: 782 KSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRI 841
Query: 344 KDEYEFD-EDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKA 402
+ +FD +DE+ +D++ K+ + + +S + K E ++++ K
Sbjct: 842 PNTKDFDSSEDEKHSKKGMDNQG--HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 899
Query: 403 SHRILSD-TSDEEDASVTVGTGEKL--RLSAHTILPGSKTREPSNAKQQKEKNKVKKKRK 459
+ L D ++ AS + +KL + + T L K E + K + K K KK +
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE-TKEKSKHLKTKTCKKVQ 958
Query: 460 KETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLS 519
+F K+ +SE + + S+ G +++ K PS F
Sbjct: 959 DGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK----------------KKPSDFKKKV 1002
Query: 520 ASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDY 579
+ SS+ T P E+ + +D
Sbjct: 1003 IKMEQQYESSSD--------------------GTEKLPEREEICHFPKGIKQIKNGTTDG 1042
Query: 580 SSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHK 639
+ + K +K+ E A S K S+E K G+ K+ K K
Sbjct: 1043 EKKSKKIRD-KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1101
Query: 640 NKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEK 699
K + CS S K ED SDK +
Sbjct: 1102 RKRQ-DCSSSDTEKYSM----KEDGCNSSDK----------------------------R 1128
Query: 700 LSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSP---KEE 756
L +++L E+ ++ S + K+ S S EE NK +K+R+ +K KE+
Sbjct: 1129 LKRIELRER----RNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEK 1184
Query: 757 KLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYRE------ 810
K + K+K D S +D+++D + E E K K E +
Sbjct: 1185 KRNSLRTSTKRKQADITS--SSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFC 1242
Query: 811 DSAFDEYCNKNQFL-----------ENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWD 859
S+ DE +K+ + EN K L ++ + SD D S D + E+
Sbjct: 1243 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD-EDGSSDDEPEEGKK 1301
Query: 860 SPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
+ D AK + + E DS +K YR R K ++ E+
Sbjct: 1302 RTGKQNEENPGDEEAK------NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1355
Query: 920 RKEQTEKHKSVPG----YLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREE 975
+K + ++HK V G +S +D + + E+G E + + R + A + E
Sbjct: 1356 KKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE----EVSESEDEQRPRTRSAKKAE 1411
Query: 976 LKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDK 1035
L+E + +K K K E + + +E+++ ++E +E+ + E +E +D
Sbjct: 1412 LEE--NQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
Query: 1036 DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGII 1095
KS +K +K + DK E ++ + +++ER+ + + + ++EK I
Sbjct: 1470 SKSPGKGRKKIRKILKDDKLRTETQNALK-------EEEERRKRIAEREREREKLREVIE 1522
Query: 1096 SEDFSEKK 1103
ED S K
Sbjct: 1523 IEDASPTK 1530
Score = 77.8 bits (190), Expect = 1e-13
Identities = 121/544 (22%), Positives = 221/544 (40%), Gaps = 74/544 (13%)
Query: 289 YTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDE-- 346
Y SS + + + E E+ F N T +K K + K T+ KDE
Sbjct: 1009 YESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDK-------TSKKKDELS 1061
Query: 347 -YEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHR 405
Y + D +DK Y +E K + + + + ++T K +
Sbjct: 1062 DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT--EKYSMKE 1119
Query: 406 ILSDTSDEEDASVTVGTGEKLRLSAHT--ILPGSKTREPSNAKQQKEKNKVKKKRKKETK 463
++SD+ + + L +T I GS + S+A++ E NK KK+R K
Sbjct: 1120 DGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSS---SDAEESSEDNKKKKQRTSSKK 1176
Query: 464 GREVRFGKRSDKFCSSE-------SESESSESGEDDRDSLG--SSGCLKGSPLVLKDPSL 514
+ K+ + +S + S SS+ +DD++S+G SS K P+ +L
Sbjct: 1177 KAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVT---ENL 1233
Query: 515 FSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLT 574
S S G A K P D +N I+ L + + L+
Sbjct: 1234 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN--RIAK------KMLLEEIKANLS 1285
Query: 575 SESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV-PKLDKEGKVVKKHK 633
S+ D SS+ +E +KR +++P A+ V + D + + KK +
Sbjct: 1286 SDEDGSSDDEP----------EEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPR 1335
Query: 634 TKHK---HK-NKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKH 689
+H+ HK G+ ++ K K E+++ K ++ + + E+ ++ + +
Sbjct: 1336 YRHRLLRHKLTVSDGESGEEKKTKPK----EHKEVKGRNRRKVSSEDSEDSDFQESGVSE 1391
Query: 690 DRDHFKKEEK-----LSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEK 744
+ + E++ K +LEE + +K +K +RIK +E+ NK+
Sbjct: 1392 EVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIK---------VQEDSSSENKSNS 1442
Query: 745 ERSLKEKSPKEEKLRLYKEERKKKSKD--RPSKLEKK--NDLKEDKISKEKEKIFKEDKE 800
E +EK +EE+ +EE + ++ D P K KK LK+DK+ E + KE++E
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Query: 801 KLKK 804
+ K+
Sbjct: 1503 RRKR 1506
Score = 67.4 bits (163), Expect = 2e-10
Identities = 135/574 (23%), Positives = 233/574 (40%), Gaps = 77/574 (13%)
Query: 291 SSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKN--PEPQKATAPVKDEYE 348
S +E S S E S T + + GL A+ + Q D+ +
Sbjct: 925 SGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQ 984
Query: 349 FDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSY-------TKNNTIAPKK 401
+ E+ + P K ++K + + E+ S+ +P+ E + KN T +K
Sbjct: 985 SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEK 1044
Query: 402 ASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKE 461
S +I TS ++D LS + K +++ +K KN + KK
Sbjct: 1045 KSKKIRDKTSKKKD-----------ELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1093
Query: 462 TKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSAS 521
K KR D CSS S++E ED +S S LK + L++ SS +
Sbjct: 1094 CKLLGKSSRKRQD--CSS-SDTEKYSMKEDGCNS--SDKRLKR--IELRERRNLSSKRNT 1146
Query: 522 STSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTR---LTSES- 577
GSS++ + S D K RT + K + +SL ST+ + +TS S
Sbjct: 1147 KEIQSGSSSSDAEESSE-DNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSS 1205
Query: 578 ------DYSS--EGSSVES-LKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKL------ 622
D +S EGSS E +KPV + LS SS + A+ K
Sbjct: 1206 SDIEDDDQNSIGEGSSDEQKIKPVTEN------LVLSSHTGFCQSSGDEALSKSVPVTVD 1259
Query: 623 ------DKEGKVVKK---HKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSK--QKSDKA 671
D E ++ KK + K + E G E K + E++ +++
Sbjct: 1260 DDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQ 1319
Query: 672 ILLENDLSTENKLK------VLKHD---RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIK 722
+ E+D +E K +L+H D EEK +K K E KE ++ + +
Sbjct: 1320 VNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK-EHKEVKGRNRRKVSSED 1378
Query: 723 DTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDL 782
+ D S E+ +++E E+ + +S K+ +L + K+K K R K+++ +
Sbjct: 1379 SEDSDFQESGVSEE--VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS- 1435
Query: 783 KEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDE 816
E+K + E+E+ KE++E+ ++E+ E+ D+
Sbjct: 1436 SENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 111 bits (278), Expect = 8e-24
Identities = 114/530 (21%), Positives = 232/530 (43%), Gaps = 89/530 (16%)
Query: 1013 DGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGK 1072
DG D+ER + + ER +EK Q ++E D+ +E++ K++H+ +
Sbjct: 50 DGDDRERNRQKERERRREKR--------------QTERETDR-KRERRREKDRHRK---R 91
Query: 1073 DKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMG 1132
D+ R+ D+ KE++ + D +K+ + KE+ E E +R+
Sbjct: 92 DRHRERQRDREKERERQTDR---ERDRQREKERNRQKER----------ERETERE---- 134
Query: 1133 SGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHP---ERQKDKEPRDRRKDRG 1189
GE +TDG +E+E R+A + ++Q RQK++E R++R
Sbjct: 135 -----GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR 189
Query: 1190 AADAGRDKKEKVFEKH----KEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKK 1245
+ R+K+ K ++H +E++ + TE +RK + T ++++Q+ E+ +K
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKRQ-----TDRERDRQRKTEREREK 244
Query: 1246 HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSS 1305
A ++A + E+ DKE +ER+ R D ++ E+ + R D+ +E
Sbjct: 245 QAERERASERETER-DKE--RERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKR 301
Query: 1306 DSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRER 1365
+ +R +E ++ R+ E+ +E+ER R + +K +R+R
Sbjct: 302 ERQRERERE----------------RERNRKRERERERERERERQRETERDREKERERKR 345
Query: 1366 AKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFST 1425
++ + +++ + +EG R+ + + + E D + + + + D+ E
Sbjct: 346 KRQTEMDRERNRQTGREG--RRQAERERERERERDRQSAREREERERDRDRDRQKERERQ 403
Query: 1426 EKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDE-KERHRDRHADGL 1484
+KD+ D +RE K+ E+E + ++ RE+ RE+ + + +ER R+R D
Sbjct: 404 TEKDR-DGQRETEKQRERE---------KDRESERGRERGREREKQKGRERDRERQTDRQ 453
Query: 1485 LRHHRDELLRHHRDEQKPA-----TRDKDSPPRVLKDKSRDEGPRLGDAK 1529
R + + A D + P R ++ KS E P+ +
Sbjct: 454 AGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTR 503
Score = 102 bits (253), Expect = 7e-21
Identities = 113/528 (21%), Positives = 230/528 (43%), Gaps = 54/528 (10%)
Query: 884 DSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRE 943
D +ER R +R+ R+ +R+ D+ E+R+E+ K ++ ++R+
Sbjct: 52 DDRERNRQKERERRREKRQT-----ERE-TDRKRERRREKDRHRKR------DRHRERQR 99
Query: 944 SAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERH 1003
E R+R+ E ++R R + +E RE +E E G ++DG + ER
Sbjct: 100 DREKERERQTDRERDRQREKERNRQKERERETEREG--ERGRDRQTDGQRER-----ERQ 152
Query: 1004 HPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKC-QKDKEFDKCFKEKKDT 1062
A EKE++ D+ER+ +T+ R KE+ +K++ E+ E+ +K+ + + E+
Sbjct: 153 RDA-EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211
Query: 1063 KEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDE 1122
+E+ ++T + ERK D+ ++++ K +E EK+ +++ + D +
Sbjct: 212 RERERETE-TETERKRQTDRERDRQRK------TEREREKQAERERASERETERDKERER 264
Query: 1123 SED---DRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYAS-DRHRKSSDKQHPERQKD 1178
D DRD + + RT+ +E E RE +R R+ + K+ ER+++
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Query: 1179 KE-------PRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDR---KDRASVDS 1228
+E RDR K+R + + ++ + ++ + E+ ++R +DR S
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE 384
Query: 1229 TQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEA 1288
++++ + + E++ E + + + +E K+R+S R + + E+ +++
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR---EREKQKG 441
Query: 1289 LHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKE 1348
RE D+ + T P TA V ++P + PE K
Sbjct: 442 RERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAAS 501
Query: 1349 RH----RHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQY 1392
R + +S + R R + EK+ +G G R+ SG +
Sbjct: 502 TRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQG-----GEGRRPSGGF 544
Score = 100 bits (250), Expect = 1e-20
Identities = 88/411 (21%), Positives = 182/411 (44%), Gaps = 32/411 (7%)
Query: 879 ETVKEDSKERRRDSRAREK-RDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEK 937
E +E + R+RD R RE+ RD + R+ DR+ D+ EK + + ++ + E+
Sbjct: 80 ERRREKDRHRKRD-RHRERQRDREKERERQTDRE-RDRQREKERNRQKERERETEREGER 137
Query: 938 DKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDK--------- 988
+ R+ + R+R+ E +ER+ R + + R KE E +++
Sbjct: 138 GRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREK 197
Query: 989 ----SDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDK-SEKSIL 1043
D +G E E E+K D+ER + K ER +EK +++++ SE+
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 1044 EKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKK 1103
++++E D+ + KE+ + T K + R + + K+E+ + + K+
Sbjct: 258 RDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR 317
Query: 1104 DDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDR 1163
+ ++ +E+ + E +RD K +++ R Q EGR +R
Sbjct: 318 ERERERERE------RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER 371
Query: 1164 HRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDR-KD 1222
R+ + R++++ RDR +DR +KE+ + K++ + TEK ++R KD
Sbjct: 372 ERERERDRQSAREREERERDRDRDR--------QKERERQTEKDRDGQRETEKQREREKD 423
Query: 1223 RASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRS 1273
R S + + ++K + + D+ + +++S + +++RS
Sbjct: 424 RESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARS 474
Score = 100 bits (249), Expect = 2e-20
Identities = 109/504 (21%), Positives = 218/504 (43%), Gaps = 48/504 (9%)
Query: 1064 EKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDES 1123
+ HKD G D+ER ++ + ++++ +E +++K +++ +EK + E
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQ-----TERETDRKRERR-REKDRHRKRDRHRER 97
Query: 1124 EDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKE--- 1180
+ DR+ K E D +EKE R+ + R+ ++ ER +D++
Sbjct: 98 QRDRE-------KERERQTDRERDRQREKERNRQ-----KERERETEREGERGRDRQTDG 145
Query: 1181 PRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNK---QK 1237
R+R + R A + ++ ++ E+ ++ E+ K+R++R + ++K+NK +
Sbjct: 146 QRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRH 205
Query: 1238 LPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSN 1297
E++ E + +++ K ++D+E ++RK+ R EK E RE
Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTERER-------EKQAERERASERETER 258
Query: 1298 DKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSS 1357
DK E D DR + + ++ RE+ E+ +E+ER R +
Sbjct: 259 DKERERERDRDRDRDRRQ-KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR 317
Query: 1358 KKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELD 1417
++ +RER E+ ++E D ++ RK Q E D G +A+ E E +
Sbjct: 318 ERERERER---ERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERE 374
Query: 1418 KTIELFSTEKKDKNDSEREPSKKIEKELK-PYGSSAINILKEKKKREKHREKWRDEKERH 1476
+ + S ++++ + +R+ ++ E+E + +++++REK RE R +ER
Sbjct: 375 RERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERG-RERG 433
Query: 1477 RDRHAD-GLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFK 1535
R+R G R + R ++K +T + PPR + P + ++K
Sbjct: 434 REREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGI--RWK 491
Query: 1536 DGAEKEK--------GDPVKMSNG 1551
E K G P K S G
Sbjct: 492 SSPEDPKAASTRFPWGRPAKASRG 515
Score = 98.6 bits (244), Expect = 7e-20
Identities = 103/476 (21%), Positives = 217/476 (45%), Gaps = 75/476 (15%)
Query: 623 DKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTEN 682
D +G ++++ K + + +EK Q +E K +D +K D+ + D E
Sbjct: 48 DADGDDRERNRQKERERRREKRQTE--RETDRKRERRREKDRHRKRDRHRERQRDREKER 105
Query: 683 KLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKA 742
+ + +RD +++E+ ++ K E+E + E+ R D ++ R EK+R +
Sbjct: 106 ERQT-DRERDRQREKER-NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQT 163
Query: 743 EKERSL-----------KEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEK 791
++ER +EK+ +E + R + E++ K++DR S+ ++ + +E + E
Sbjct: 164 DRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE-RERETETET 222
Query: 792 EKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFD 851
E+ + D+E+ ++ K RE ++ + + E E + + +RDR D D
Sbjct: 223 ERKRQTDRERDRQRKTERER---EKQAERERASERETERDKERERERDR------DRDRD 273
Query: 852 FKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRD 911
+ ++ R+ ++D + E +E ++R R R RE+ R RK++R+
Sbjct: 274 RRQKE---------RERQTDRKRQRRTERDRETERKRER-QRERERERERN---RKRERE 320
Query: 912 YLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEA 971
+ +R+ +TE+ + E+++KR+ E R+R R+ GR +A
Sbjct: 321 RERERERERQRETERDRE-----KERERKRKRQTEMDRER--------NRQTGREGRRQA 367
Query: 972 HREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEK 1031
RE +E +D+ R RE+++ KER+ +T+ +R ++
Sbjct: 368 ERERERE-----RERDRQSA----------REREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 1032 SSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKK 1087
++K + +KD+E ++ +E+ +EK K +D+ER+ G+++K
Sbjct: 413 ETEKQRER-------EKDRESER-GRERGREREKQKGRE-RDRERQTDRQAGRQRK 459
Score = 96.7 bits (239), Expect = 3e-19
Identities = 88/456 (19%), Positives = 193/456 (42%), Gaps = 38/456 (8%)
Query: 1098 DFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGRE 1157
DFS ++ + + + D DDR+ + + +++E RE
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 1158 AYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKY 1217
DRHRK +H ERQ RDR K+R +++ E++++K+ + TE+
Sbjct: 85 ---KDRHRKRD--RHRERQ-----RDREKERERQTDRERDRQREKERNRQKERERETERE 134
Query: 1218 KDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAE 1277
+R D ++++ ++ ++ E++ E + +++ + ++E K R+ R + +
Sbjct: 135 GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ 194
Query: 1278 KSLLEKLEEEALHEYREDSNDKISEVSSD--SFTDRGQEPGLTAFLEVSFTEPPGDDKPR 1335
+ K E+ RE ++ +E ++ TDR ++ ++ R
Sbjct: 195 REKENKTEDRHSERGRERERERETETETERKRQTDRERD------------RQRKTERER 242
Query: 1336 ESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKD 1395
E E+ E+E R ++ DR+R +++K +++ + R + +++
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302
Query: 1396 FLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKEL-----KPYGS 1450
N K + E E ++ E ++D+ + ERE +K + E+ + G
Sbjct: 303 RQRERERERERNRKRERERERERERERQRETERDR-EKERERKRKRQTEMDRERNRQTGR 361
Query: 1451 SAINILKEKKKREKHREKW--RDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKD 1508
+ +++RE+ R++ R+ +ER RDR D + R+ RD Q+ + ++
Sbjct: 362 EGRRQAERERERERERDRQSAREREERERDRDRD--RQKERERQTEKDRDGQRETEKQRE 419
Query: 1509 SPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGD 1544
KD+ + G G + K+K ++ + + D
Sbjct: 420 RE----KDRESERGRERGREREKQKGRERDRERQTD 451
Score = 94.4 bits (233), Expect = 1e-18
Identities = 108/480 (22%), Positives = 215/480 (44%), Gaps = 70/480 (14%)
Query: 722 KDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKND 781
KD + D R +K+R + EK ++ +E K E+ R E+ + + +DR + ++ +
Sbjct: 47 KDADGD-DRERNRQKERERRREKRQTERETDRKRERRR---EKDRHRKRDRHRERQRDRE 102
Query: 782 LKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRW 841
KE + ++E+ + +KE+ ++++ RE E E + +D QR+R
Sbjct: 103 -KERERQTDRERDRQREKERNRQKERERETER-----------EGERGRDRQTDGQRER- 149
Query: 842 FSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYR 901
+ D + E R+ ++D + +T + KER R+ +E+R+
Sbjct: 150 -----ERQRDAEKE----------RERQTDRERQ--RQTERNRQKEREREKNRQERRERE 192
Query: 902 EPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKER 961
R+K+ D++SE+ +E+ + ++ +E ++KR+ E R RK E K+
Sbjct: 193 RQ--REKENKTEDRHSERGRERERERETE----TETERKRQTDRERDRQRKTEREREKQA 246
Query: 962 RDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKE 1021
RA E R++ +E + D D R R+KE++ D++R+
Sbjct: 247 ERERASERETERDKERE--------RERDRD---------RDRDRRQKERERQTDRKRQR 289
Query: 1022 KTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLD 1081
+T+ +R E+ ++ + + E+ +K + + +E++ +E +D K++ERK
Sbjct: 290 RTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDRE-KERERKRKRQ 348
Query: 1082 QGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEAS 1141
+++ G +E++ +++ + + +E E DRD K E
Sbjct: 349 TEMDRERNRQTGREGRRQAERERERERERDRQSARE--REERERDRDR---DRQKERERQ 403
Query: 1142 DLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDK---EPRDRRKDRGAADAGRDKK 1198
DG +E E+ RE DR + ++ ER+K K R+R+ DR AGR +K
Sbjct: 404 TEKDRDGQRETEKQRER-EKDRESERGRERGREREKQKGRERDRERQTDR---QAGRQRK 459
Score = 87.8 bits (216), Expect = 1e-16
Identities = 93/476 (19%), Positives = 195/476 (40%), Gaps = 83/476 (17%)
Query: 1179 KEPRDRRKDRGAADAGRDKKEKVFEKHKEKK-DKESTEKYKDRKDRASVDSTQDKKNKQK 1237
+ PR R + DA D +E+ +K +E++ +K TE+ DRK
Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK---------------- 78
Query: 1238 LPEKAEKKHAAEDKAKSKHKEKS-DKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296
+ ++ + + +H+E+ D+E +ER++ R D ++ ++E RE
Sbjct: 79 ---RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKE-----RERE 130
Query: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356
++ E D TD +E ++ R++ E+ ++ER R + +
Sbjct: 131 TEREGERGRDRQTDGQRER----------------ERQRDAEKERERQTDRERQRQTERN 174
Query: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
+K +RE+ ++E+ E++ + E + R E++ + + E E
Sbjct: 175 RQKEREREKNRQERRERERQREKENKTEDRHSERGRERE------------RERETETE- 221
Query: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGS---SAINILKEKKKREKHREKWRD-- 1471
TE+K + D ER+ +K E+E + ++ + K+RE+ R++ RD
Sbjct: 222 --------TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273
Query: 1472 ----EKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGD 1527
E+ER DR R+ + R ++ R+++ +++ R+ +
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333
Query: 1528 AKLKEKFKDGAEKEKGDPVKMSN----------GNDKVAPSKDPGKKDARPREKLLGDGD 1577
+ +EK ++ K + + + N + ++ ++ AR RE+ D D
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRD 393
Query: 1578 LMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRS-GDPKLKEKAKPADDGRK 1632
++KD + + ++ +ER K E R R G + K+K + D R+
Sbjct: 394 RDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQ 449
Score = 45.4 bits (106), Expect = 7e-04
Identities = 37/201 (18%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 1433 SEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDEL 1492
S R P + + G + + + ++R + +E+ R ++R +R D R++
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 1493 LRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGN 1552
RD + RD++ D+ RD + KE+ ++ + + + ++G
Sbjct: 87 RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ 146
Query: 1553 DKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLR 1612
+ +D K+ R T ER Q+ E + +R +E+ +Q + R
Sbjct: 147 RERERQRDAEKERER------------QTDRER---QRQTERNRQKEREREKNRQERRER 191
Query: 1613 HRSGDPKLKEKAKPADDGRKK 1633
R + + K + + ++ GR++
Sbjct: 192 ERQREKENKTEDRHSERGRER 212
Score = 37.0 bits (84), Expect = 0.26
Identities = 64/397 (16%), Positives = 159/397 (40%), Gaps = 48/397 (12%)
Query: 438 KTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRS-DKFCSSESESESSESGEDDRDSL 496
K RE +++ + + ++ R+KE + R G+R D+ + E E E +R+
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER- 161
Query: 497 GSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISS 556
+ + + +++ + + + R + +
Sbjct: 162 -------------------QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTE 202
Query: 557 PAWSEVSSLSDSTR-TRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
SE + R T +E ++ K R+R++ +R SE+++
Sbjct: 203 DRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER 262
Query: 616 EGAVPKLDKEGKVVKKHKTKHKHKN-KEKGQCSISQELKLKSFTYEYEDSKQKSDKAILL 674
E + D++ ++ K + + + K + + +E + K + +++ ++
Sbjct: 263 ER---ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 675 ENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEE---------KEWLFKDEKSLKRIKDTN 725
E + E + + + +RD K+ E+ K + E +E + E+ +R ++ +
Sbjct: 320 ERERERERE-RQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERD 378
Query: 726 KDISRSFRE---EKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDL 782
+ +R E ++DR + E+ER ++ K+ + E+++++ KDR S+ ++
Sbjct: 379 RQSAREREERERDRDRDRQKERER----QTEKDRDGQRETEKQREREKDRESERGRERGR 434
Query: 783 KEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCN 819
+ +EK+K + D+E+ + R+ Y N
Sbjct: 435 E-----REKQKGRERDRERQTDRQAGRQRKRSTLYVN 466
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 111 bits (278), Expect = 8e-24
Identities = 54/116 (46%), Positives = 77/116 (66%), Gaps = 3/116 (2%)
Query: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
K N+RN+ GET LHRA I G RR+++L+ +G +N +D+ GWT LHEACN G+ ++ +
Sbjct: 521 KWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRF 580
Query: 220 LLAAGAEVNT---KGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLK 272
LL GA V+ +G + TPLHDA N GH++V +LLL G + RKG +PL+
Sbjct: 581 LLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Score = 49.7 bits (117), Expect = 4e-05
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 190 EGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKV 249
+G+ N ++ G T LH AC G + L+ G +N + TPLH+A N GH ++
Sbjct: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
Query: 250 VKLLLRYGG---NPQQSNRKGETPL 271
V+ LL +G +P +G TPL
Sbjct: 578 VRFLLDHGAAVDDPGGQGCEGITPL 602
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 110 bits (276), Expect = 1e-23
Identities = 195/822 (23%), Positives = 283/822 (34%), Gaps = 101/822 (12%)
Query: 1614 RSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLK----ESTPI--PPAAENK 1667
RSG PA + K + A +PP + PP KD S+P+ P + K
Sbjct: 254 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTK 313
Query: 1668 LHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSC 1727
P D+ A + LP SP P P+P++ PS + + P TP
Sbjct: 314 ARPVPPPDN----AATPLPATLPPSPPLATPLPLAPPSPSAP---PSLQTLPSPPATPPS 366
Query: 1728 SADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLSTNL 1787
A S + P+ P+ P S+ S L QAP PL+ +
Sbjct: 367 QA----------PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL-----QAPPSPLALSS 411
Query: 1788 YRSV----SVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPL-----PPV 1838
++ S ++ T F Q S+ + S S P S +APL PP+
Sbjct: 412 LQATTSLGSPTLQAT--HSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPL 469
Query: 1839 PAEKFACLSPGYYSPDYGLPSPKVDAL--HCPPAAVVTVTPSPEGVFSSLQAKPSPSPRA 1896
+SP SP P + +L H P A + ++ P SSL +P A
Sbjct: 470 QTSLSPAVSP-LSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPA 528
Query: 1897 ELLVPSLE---GALPPDLDTSEDQQATAAIIPPEPSYLEPLD--EGPFSAVITEEPVEWA 1951
L P LE PP L T+ T + P PL P + E P A
Sbjct: 529 SLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIA 588
Query: 1952 HPSEQ---ALASSLIGGTSENPVS-----WPVGSDLLLKSPQRFPESPKRFCPADPLHSA 2003
P Q ALAS + G P+S P L P + P SP P PL +
Sbjct: 589 TPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATP 648
Query: 2004 APGPFSA-----SEAPYPAPPASP--APYALPVAEPGLEDVKDGVDAVPAAISTSEAAPY 2056
+P +A +AP+ PP+ P AP++ P + P A P+ + P
Sbjct: 649 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708
Query: 2057 APPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVE 2116
+PP+ + P+AP P A QV P + + +
Sbjct: 709 SPPAS-PPMSPSATPPPQAP------PPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLL 761
Query: 2117 PVPWADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVING 2176
P P L + P + P P Q A P++ +PP P AP +
Sbjct: 762 AAPPLQVPPSPPASLPMSPLAKP--PPQAPPAL--ATPPLQALPSPPASFPGQAPFSPSA 817
Query: 2177 GDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPD 2236
+ +A PP PP A+ L ++ P P P L P PD
Sbjct: 818 SLPMSPLATPPPQAPPVLAAPLL--QVPPSPPASPTLQ-----------APRRPPTPGPD 864
Query: 2237 SSVE---------PAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADG 2287
+SV P P PP R S G + G +++ P+ + +
Sbjct: 865 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE-ELRGYDSGPEGGAA 923
Query: 2288 AGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQ 2347
A P D E + A PA G P A P A P P + +
Sbjct: 924 ASPPPDAELA-ACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT---GPGSADGLCTIYETE 979
Query: 2348 SKQGPPPSEKECAPTPAPVTR-AKARGSEDDDAQAQHPRKRR 2388
+ P+ P P+P T KA A ++ P++ R
Sbjct: 980 GPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQAR 1021
Score = 100 bits (248), Expect = 2e-20
Identities = 188/758 (24%), Positives = 267/758 (35%), Gaps = 91/758 (12%)
Query: 1623 KAKPADDGRKKGLDIPAKKPPG--------LDPPFKDKKLKEST-PIPPAAENKLHPASG 1673
KA+P +PA PP L PP T P PPA P S
Sbjct: 313 KARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSM 372
Query: 1674 ADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYA 1733
+ P + +P P + P S L+ S + +P+ A ++
Sbjct: 373 TTPP--MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLG-SPTLQAT-HS 428
Query: 1734 DLVFDCADSQHSTPVPTAPTSAC--SPSFFDRFSVASSGLSENASQAPARPLSTNL---- 1787
L +Q S P+ P S SP S+ +S + + PLS+ L
Sbjct: 429 FLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP 488
Query: 1788 YRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSMEDR-APLPPVPAEKFACL 1846
+++S +P+ S +P + S PPS++ A L P E L
Sbjct: 489 LQALSSLASHSPQAPLS-------SLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSL 541
Query: 1847 SPG-YYSPDYGLPSPKVDALHCPPAAVVTVTPSP-----EGVFSSLQAKPSPSPRAELLV 1900
+P + L +P ++ CP + PSP SS+ P +P A L
Sbjct: 542 APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPA-LAS 600
Query: 1901 PSLEGALPPDLD---TSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQA 1957
P L+G P L T Q +PP + P P S + T P + A
Sbjct: 601 PPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSP-----QAPNA 655
Query: 1958 LASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPA 2017
LA L+ P S PV + P P SP P+ S A P +P +
Sbjct: 656 LAVHLLQAPFSPPPSPPVQAPF--SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713
Query: 2018 PPASPAPYALPVAEPGLE----DVKDGVDAVPAAISTSEAAPYAPP----SGLESFFSNC 2069
PP SP+ P A P L V A P ++ P PP L+ S
Sbjct: 714 PPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773
Query: 2070 KSLPEAPLDVAPEPACVA-AVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPE 2128
SLP +PL P A A A ++AL SF GQ P++ + + P
Sbjct: 774 ASLPMSPLAKPPPQAPPALATPPLQALPSPPASF---------PGQ---APFSPSASLPM 821
Query: 2129 DDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMP-PGAPGVINGGDVSTVVAEEP 2187
L P P + L + P +L P P PG ++G ++ +A P
Sbjct: 822 SPLATPPPQAPPV-LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 880
Query: 2188 PALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSSVEPAPVPPE 2247
P P S+ L P+ +G + A + PEE D A PP
Sbjct: 881 PPPPSRSPSSTLSG---PDLAGH---------SSSATSTPEELRGYDSGPEGGAAASPPP 928
Query: 2248 QRPLGSGDQGAEAEG--PPAASLCAPDGPAPNTVAQAQ-AADG-------AGPEDDTEAS 2297
L + A + G PP A AP P P A +ADG GPE T A
Sbjct: 929 DAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAP 988
Query: 2298 RA--AAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIP 2333
A P+ G GG A ++ +PK R+ E+P
Sbjct: 989 GALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELP 1026
Score = 85.1 bits (209), Expect = 8e-16
Identities = 174/786 (22%), Positives = 248/786 (31%), Gaps = 113/786 (14%)
Query: 1621 KEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASG------A 1674
++KAK R PA + PGL P + P+ PAA L A A
Sbjct: 5 RDKAKAGAAART-----PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLA 59
Query: 1675 DSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHTPRTPSCSADDYAD 1734
+ + G + E P + P +S T P S R P+ + A
Sbjct: 60 ERAGGIGGATIPESAPRA-GPTRSAGTSSRNPAS--------------RPPASGRGERAP 104
Query: 1735 LVFDCADSQHSTPVPTAPTSACSPSFFD--RFSVASSGLSENASQAPAR-PLSTNLYRSV 1791
+ + S+P + T+ P R S + A++AP R LS R
Sbjct: 105 PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT 164
Query: 1792 SVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMP-PSMEDRAPLPPVPAEKFACLSPGY 1850
S TP + ++S A + P P PS P PP + + S
Sbjct: 165 SGPTPGTPSPAMA-------RRSRAAGTEVGLPRPAPSAR---PRPPTEGPRKSVSS--- 211
Query: 1851 YSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPD 1910
+ ++ P A P A P+ + SS SP+ PS G
Sbjct: 212 -ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG----PSARGTPRAP 266
Query: 1911 LDTSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENP 1970
S+ + + P D P ++ P+ PS GT P
Sbjct: 267 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS----------GTKARP 316
Query: 1971 VSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFS-ASEAPYPAPPASPAPYALP- 2028
V P + P P SP A PL A P P + S P+PPA+P A P
Sbjct: 317 V--PPPDNAATPLPATLPPSPPL---ATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPS 371
Query: 2029 VAEPGLEDVKDGVDAVPAAISTSEAAP--YAPPSGL-------------------ESFFS 2067
+ P ++ P + S +P APPS L SF +
Sbjct: 372 MTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLT 431
Query: 2068 NCK-------SLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPW 2120
+ P P P+ + A + A PL+ S LS + P+
Sbjct: 432 MSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQA 491
Query: 2121 ADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPP-EEMPPGAPGVIN--GG 2177
+ A L +P L Q+ A P PP E +P AP +
Sbjct: 492 LSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASA 551
Query: 2178 DVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERA----RG 2233
++T E PP P P + P P P + A P A +G
Sbjct: 552 PLTTPHLETPPCPAP------CPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQG 605
Query: 2234 DPDSSVEPAPVPPEQRPLGSGDQGAEA-----EGPPAASLCAPDGPAPNTVAQAQAADGA 2288
P + P PP Q P +A PP + L P APN +A
Sbjct: 606 LPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 665
Query: 2289 GPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQS 2348
P +P PP + P A P + AP ++ P A
Sbjct: 666 SPPPSPPVQAPFSPPASPP--VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP 723
Query: 2349 KQGPPP 2354
Q PPP
Sbjct: 724 PQAPPP 729
Score = 58.9 bits (141), Expect = 6e-08
Identities = 118/501 (23%), Positives = 165/501 (32%), Gaps = 69/501 (13%)
Query: 1926 PEPSYL-EPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLL-LKS 1983
P PS P EGP +V + PS A GG + P S + S L S
Sbjct: 192 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 251
Query: 1984 PQRFPESPKRFCPADPLHSAAPGP--FSASEAPYPAPPASPAPYAL------PVAEPGLE 2035
P R S R P P H + P P A P PP A AL P+A P
Sbjct: 252 PARSGPSA-RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS 310
Query: 2036 DVK--------DGVDAVPAAISTS----EAAPYAPPS-GLESFFSNCKSLPEAPLDVAPE 2082
K + +PA + S P APPS S P P AP
Sbjct: 311 GTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPP 370
Query: 2083 PAC---VAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLP 2139
+ A ++ + P++ S L Q P P A + + LG +L
Sbjct: 371 SMTTPPMQAPPSLQTIPPIQVPHSLTSPSL----QAPPSPL--ALSSLQATTSLGSPTLQ 424
Query: 2140 E----LPLQTKDAADGEAEPVEESLAPPEEMP-------PGAPGVINGGDVSTVVAEEPP 2188
L + + P + PP+ P P +P + + P
Sbjct: 425 ATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPL 484
Query: 2189 ALPPDQASTRLPAELEPEPSGE---PKLDVALEAAVEAETVPEERARGDPDSSVEPAPVP 2245
+ P QA + L + P P L+ A + P P ++ P+ P
Sbjct: 485 TIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENL-PSLAP 543
Query: 2246 PEQRPLGSGDQGAEAEGPPAASLC---APDGP-------APNTVA----QAQAADGAGP- 2290
P + + E PP + C AP P P+++A QA A + P
Sbjct: 544 PPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPL 603
Query: 2291 ---EDDTEASRAAAPAEGPPG-GIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLAN 2346
+ A P + PP + P A P P A P +P PQ +L
Sbjct: 604 QGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL-- 661
Query: 2347 QSKQGPPPSEKECAPTPAPVT 2367
Q+ PPPS AP P +
Sbjct: 662 QAPFSPPPSPPVQAPFSPPAS 682
Score = 39.3 bits (90), Expect = 0.052
Identities = 53/208 (25%), Positives = 72/208 (34%), Gaps = 51/208 (24%)
Query: 2184 AEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAA--------------VEAETVPEE 2229
A P A P + R P P P P L AA + T+PE
Sbjct: 14 ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES 73
Query: 2230 RARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAG 2289
R P S + P RP SG +G A PPA + +P V+ A G
Sbjct: 74 APRAGPTRSAGTSSRNPASRPPASG-RGERA--PPAKN------TSPGPVSSPGRASG-- 122
Query: 2290 PEDDTEASRAAAPAEGPPG--GIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQ 2347
GP G G++ A E +A +AP+ R+ A +
Sbjct: 123 -----------TTRPGPLGQKGLRISAEETVARGKATEAPK---------RSALSAGARR 162
Query: 2348 SKQGPPPSEKECAPTPAPVTRAKARGSE 2375
GP P P+PA R++A G+E
Sbjct: 163 DTSGPTPG----TPSPAMARRSRAAGTE 186
Score = 37.4 bits (85), Expect = 0.20
Identities = 60/237 (25%), Positives = 80/237 (33%), Gaps = 39/237 (16%)
Query: 2163 PEEMPPGAPGVINGGDVSTVVAEEPPA------LPPDQAST--------RLPAELEPEPS 2208
PE P P + G S A PPA PP + ++ R P P
Sbjct: 71 PESAPRAGP-TRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129
Query: 2209 GEPKLDVALEAAV---EAETVPEERA-----RGDPDSSVEPAPVPPEQRPLGSGDQGAEA 2260
G+ L ++ E V +A P+ A R D P P R S G E
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARR--SRAAGTEV 187
Query: 2261 EGP-PAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKP 2319
P PA S P P T ++ A TE S AA GG+Q A+
Sbjct: 188 GLPRPAPSA----RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
Query: 2320 TAEAPKAPRVEEIPQRMTRNRAQMLANQSKQ------GPP---PSEKECAPTPAPVT 2367
++ P + P RA +Q K PP P K+ AP P++
Sbjct: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 103 bits (257), Expect = 2e-21
Identities = 118/673 (17%), Positives = 313/673 (46%), Gaps = 95/673 (14%)
Query: 609 SPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKE--KGQCSISQELKL-----KSFTYEY 661
S + A+ + +L KE + ++ N+E K + ++L+L
Sbjct: 151 STWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNV 210
Query: 662 EDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRI 721
++ K+K ++A L + T + + + +++EK + K EEK W R
Sbjct: 211 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR-KQEEKMW---------RQ 260
Query: 722 KDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKND 781
++ ++ RE++++ + EK +EK +E++ L ++++ ++ +++ + E+K
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 782 LKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRW 841
+E+K+ +++EK++++++ ++EK RE + Q + +++ + D++
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMRE---------QEQKMRDQEERMWEQDERLREK 371
Query: 842 FSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYR 901
+ + E W+ M+ + + + ++E+ + R +K++
Sbjct: 372 EERMREQ------EKMWEQE----EKMQEEERIREREKKMREEEETMREQEEKMQKQE-- 419
Query: 902 EPFFRKKDRDYLDKNSEKRKE---QTEKHKSVPGYLSEKDKKRRESAEA-GRDRKD-ALE 956
E + ++++++ + ++KE + EK + + E+++K R+ E G+++K E
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 957 SCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPD 1016
+E+ D + EE R++ E D+ + WE+ REKE++
Sbjct: 480 KMREQEDQMWEQEEKMRDQ------EQKMWDQEE-------RMWEQDERLREKEERMREQ 526
Query: 1017 KERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKER 1076
K+ ++ + R ++K+ +++K EK ++++ + K+ ++ +E ++ K +E+
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 586
Query: 1077 KASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFK 1136
+ + + +EK + +++ ++ +EK W + ++ E+D K
Sbjct: 587 EEKMREQEEKM-----------WEQEEKMQEQEEKMWEQEEKMWEQEEED---------K 626
Query: 1137 MGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDR-RKDRGAADAGR 1195
M E ++ + E+EE + ++ K +++ R+++++ R++ K +G + R
Sbjct: 627 MQEQEEM-----MWEQEEKMQ----EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR 677
Query: 1196 DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK 1255
+++EK+ + +E+K +E EK + ++++ ++K+ + EK E+ + +
Sbjct: 678 EQEEKM--QGQEEKMREQEEKMRGQEEKM-------WGQEEKMWGQEEKMWGQEEMREKE 728
Query: 1256 HKEKSDKEHSKER 1268
+ + KE +ER
Sbjct: 729 ERIRDQKEKMQER 741
Score = 100 bits (249), Expect = 2e-20
Identities = 110/533 (20%), Positives = 243/533 (45%), Gaps = 57/533 (10%)
Query: 880 TVKEDSKERRRDSRAREK--RDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEK 937
T++E+ + + R +EK R E +R+++R L + K +EQ EK + L E+
Sbjct: 231 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEER--LREQEGKMREQEEKMRRQEKRLREQ 288
Query: 938 DKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGL 997
+K+ RE + R++K R + E+ +E K E +++ + + +
Sbjct: 289 EKELREQEKELREQKKL----------REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 338
Query: 998 EPWERHHPAREKEKKDGPDKER--------KEKTKPERYKEK---SSDKDKSEKSILEKC 1046
WE+ RE+E+K +ER +EK + R +EK +K + E+ I E+
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRERE 398
Query: 1047 QKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDK 1106
+K +E ++ +E+++ +K ++ + +E++ + E+KEK + E++ +
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW---------EQEKMQ 449
Query: 1107 KGKEKSWYIADIFTDESED-DRDSCMGSGFKMGEASDL--PRTDGLQEKE------EGRE 1157
+ +EK W + D+ E ++ M KM E D + + ++++E E R
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 509
Query: 1158 AYASDRHRKSSDKQHPER---QKDKEPRDRRKDRGAADAGRDKKEKVFE----KHKEKKD 1210
+R R+ ++ ++ Q++++ R+ +K + D++EK+ E + +EKK
Sbjct: 510 WEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM 569
Query: 1211 KESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKS 1270
+E E ++++++ + ++ ++K+ E+ EK E+K + ++ ++E + +
Sbjct: 570 REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Query: 1271 SRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPG 1330
E+ + +EE + E E ++ ++ +GQE + E
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR---EQEEKMQGQ 686
Query: 1331 DDKPRESACLPEKLKEKERHRHSSSSSKKSHDRER-AKKEKAEKKEKGEDYKE 1382
++K RE EK++ +E + + ++E EK+E+ D KE
Sbjct: 687 EEKMREQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736
Score = 95.9 bits (237), Expect = 5e-19
Identities = 101/554 (18%), Positives = 260/554 (46%), Gaps = 59/554 (10%)
Query: 565 LSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEH--RKRASLSEKKSPFLSSAEGAVPKL 622
L +T E + E E K +RK++E R+ L E++ E K+
Sbjct: 223 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE----KM 278
Query: 623 DKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTEN 682
++ K +++ + + + + KE + ++ KL+ E E+ Q+ ++ + + + E
Sbjct: 279 RRQEKRLREQEKELREQEKE-----LREQKKLR----EQEEQMQEQEEKMWEQEEKMREQ 329
Query: 683 KLKVLKHDRDHFKKEEKL----SKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDR 738
+ K+ + + +++E+++ KM+ +E+ +DE+ R K+ E++++
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL--REKEERMREQEKMWEQEEK 387
Query: 739 SNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKED 798
+ E+ R ++K +EE+ +EE+ +K ++ + E+K + ++ ++ ++KEK+++++
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQE 446
Query: 799 KEKLKKEKVYREDSAFDEY----------CNKNQFLENEDTKFSLSDDQRDRWFSDLSDS 848
K + ++EK++ ++ + + + E ED + + RD+
Sbjct: 447 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ-------- 498
Query: 849 SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908
+ WD + R + D + E ++E K +++ + RE++ +E +
Sbjct: 499 -----EQKMWDQ---EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Query: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDAL----ESCKERRDG 964
D++ + E+ +E+ +K + + E+++K +E E R++++ + E +E+ +
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 965 RAKPEEA---HREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKE 1021
+ EE EE K E ++ + + + WE+ RE+E+K ++E K
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR-EQEEKM 669
Query: 1022 KTKPERYKEKSSDKDKSEKSILEKCQKDK-EFDKCFKEKKDTKEKHKDTHGKD--KERKA 1078
+ + E+ +E+ E+ + E+ +K + + +K + +++ + + G++ +E++
Sbjct: 670 QGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEE 729
Query: 1079 SLDQGKEKKEKAFP 1092
+ KEK ++ P
Sbjct: 730 RIRDQKEKMQERLP 743
Score = 81.3 bits (199), Expect = 1e-14
Identities = 113/578 (19%), Positives = 246/578 (42%), Gaps = 41/578 (7%)
Query: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKK 1209
+++EE RE + RK +K + ++ +E + +++ ++K+ + EK ++
Sbjct: 238 RQEEELREQ--EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQ 295
Query: 1210 DKESTEKYKDRKDRASVDSTQDK--KNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE 1267
+KE E+ K R+ + ++K + ++K+ E+ EK E++ + K+ ++E
Sbjct: 296 EKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 355
Query: 1268 RKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTE 1327
+ R + ++ L EK E E + +K+ E ++ E + E
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE-----EETMRE 410
Query: 1328 PPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKA--EKKEKGEDYKE-GG 1384
+ +E ++ KE ++ R K + ++E+ E++EK D +E G
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 1385 SRKDSGQYEKDFLEADAYGVSYNMKADIEDEL-DKTIELFSTEKK--DKNDSEREPSKKI 1441
K + EK + D D E ++ D+ ++ +++ +K + RE K
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 1442 EKELKPYGSSAINILKEKKKREKHREKWRDE---KERHRDRHADGLLRHHRDELLRHHRD 1498
++E K + +EKK +E+ ++ W E +E R R + +R +E++R +
Sbjct: 531 QQEEK--------MREEKKTQEQEKKTWDQEEKMREEERMREREKKMR-EEEEMMREQEE 581
Query: 1499 ---EQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKV 1555
EQ+ R+++ ++K +++ ++ + + K ++ +K + M +K+
Sbjct: 582 KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM 641
Query: 1556 APSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKD--LEIEERHKRHKERMK-QMEKLR 1612
++ +K EK+ + M E+M Q++ E EE+ + +E+M+ Q EK+R
Sbjct: 642 ---QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 1613 HRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPAS 1672
+ +E+ + + G + +K + +D+K K +P E P
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREK----EERIRDQKEKMQERLPEHEERCSEPCL 754
Query: 1673 GADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVL 1710
SK H V PA + P PT ++
Sbjct: 755 -PPSKVLCNMSHTGSVEPAGGEAGEGSPQDNPTAQEIM 791
Score = 63.2 bits (152), Expect = 3e-09
Identities = 88/469 (18%), Positives = 214/469 (45%), Gaps = 45/469 (9%)
Query: 1198 KEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK 1257
+E+++ + +E +++E +K + ++++ + ++ + K+ E+ EK E + + + K
Sbjct: 233 QEEMWRQEEELREQE--KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 1258 EKSDKEHSKE-RKSSRSADAEKSLLEKLE-----EEALHEYREDSNDKISEVSSDSFTDR 1311
E +E KE R+ + + E+ + E+ E EE + E E + + R
Sbjct: 291 EL--REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 1312 GQEPGLTAFLEVSFTEP----PGDDKPRESACL---PEKLKEKERHRHSSSSSKKSHDRE 1364
QE + E + + +++ RE + EK++E+ER R ++ +
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 1365 RAKKEKAEKKEKG---EDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIE 1421
R ++EK +K+E+ ++ KE ++ Q EK E + + E+++ E
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK-LWEQEKMQEQEEKIWEQEEKIRDQEE 467
Query: 1422 LFSTEKK--------DKNDSEREPSKKI-EKELKPYGS-----SAINILKEKKKREKHRE 1467
++ EKK ++ D E +K+ ++E K + L+EK++R + ++
Sbjct: 468 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 1468 K-WRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLG 1526
K W+ E++ ++ + D+ + +E+ R+++ R ++ R++ ++
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEER---MREREKKMREEEEMMREQEEKMQ 584
Query: 1527 DAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERM 1586
+ +EK ++ EK KM +K+ ++ + +K+ ++M E+M
Sbjct: 585 EQ--EEKMREQEEKMWEQEEKMQEQEEKMWEQEEK-MWEQEEEDKMQEQEEMMWEQEEKM 641
Query: 1587 LSQKD--LEIEERHKRHKERMKQMEKLRHRSGDPKLKEKAKPADDGRKK 1633
Q++ E EE+ + +E+M++ E+ + + + K++E+ + +K
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEE-KMQGQEEKMREQEEKMQGQEEK 689
Score = 63.2 bits (152), Expect = 3e-09
Identities = 81/514 (15%), Positives = 218/514 (42%), Gaps = 64/514 (12%)
Query: 322 EFEKGLKHKAKNPEPQKATAPVKDEYEFDED---DEQDRVPPVDDKHLLKKDYRKETKSN 378
E EK L+ + K QK +++ + E+ ++++++ ++K +++ E +
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 379 SFISIPKM---EVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILP 435
KM E + + ++ + K+ R ++E+ + E++R +
Sbjct: 347 MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK---MQEEERIREREKKMRE 403
Query: 436 GSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDS 495
+T K QK++ + ++ +KE + + R ++ +K E E E + +
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQ--QQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 496 LGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTIS 555
+ + G Q K WR + +
Sbjct: 462 IRDQEEMWG------------------------------------QEKKMWRQEKMREQE 485
Query: 556 SPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
W + + D + E + + + + +E +K EK +
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE--ERMREQKKMWQQEEKMREEKKTQ 543
Query: 616 EGAVPKLDKEGKVVKKHKTKHKHKN-KEKGQCSISQELKLKSFTYEYEDSKQKSDKAILL 674
E D+E K+ ++ + + + K +E+ + QE K++ E E+ ++ ++ +
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ----EQEEKMREQEEKMWE 599
Query: 675 ENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFRE 734
+ + E + K+ + + +++EE+ KM+ E++E +++ E+ ++ ++ + RE
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEE-DKMQ-EQEEMMWEQEEKMQEQEEKMWEQEEKMRE 657
Query: 735 EKDRSNKAEKERSLKEKSPKEEKLRLY-KEERKKKSKDRPSKLEKKNDLKEDKISKEKEK 793
++++ + E++ +E+ +E++ ++ +EE+ ++ +++ E+K +E+K+ ++EK
Sbjct: 658 QEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEK 717
Query: 794 IF-------KEDKEKLKKEKVYREDSAFDEYCNK 820
++ KE++ + +KEK+ +E C++
Sbjct: 718 MWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 47.0 bits (110), Expect = 3e-04
Identities = 49/239 (20%), Positives = 103/239 (43%), Gaps = 35/239 (14%)
Query: 1415 ELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKE 1474
EL + + L +EK + + +E +K+E+ A +L + + E WR E+E
Sbjct: 191 ELQEKLRLAESEKSEIQLNVKELKRKLER--------AKFLLPQVQTNTLQEEMWRQEEE 242
Query: 1475 ------------------RHRDRHADGLLRHHRDELLRHHR--DEQKPATRDKDSPPRVL 1514
R R +G +R +++ R + EQ+ R+++ R
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 1515 KDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLG 1574
K K R++ ++ + +EK + EK + KM +++ +K R +E+ +
Sbjct: 303 K-KLREQEEQMQEQ--EEKMWEQEEKMREQEEKMWRQEERLWEQ----EKQMREQEQKMR 355
Query: 1575 DGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEKAKPADDGRKK 1633
D + M + L +K+ + E+ K ++ K E+ R R + K++E+ + + +K
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 102 bits (254), Expect = 5e-21
Identities = 159/700 (22%), Positives = 272/700 (38%), Gaps = 134/700 (19%)
Query: 937 KDKKRRESAEAGRDRKDALESCKE-----------RRDGRAKPEEAHREELKECGCESGF 985
K KK++E + D D L+ +E R KP E + EE
Sbjct: 41 KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTS------- 93
Query: 986 KDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKP--ERYKEKSSDKD--KSEKS 1041
KDK KG + ++ + E+ + D + K+ KP E Y D D K K
Sbjct: 94 KDKKK----KGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK 149
Query: 1042 ILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSE 1101
K QK + K D E+ +D K KER G+ E S++F +
Sbjct: 150 AKGKAQKSNK-------KWDGSEEDEDNSKKIKERSRINSSGESGDE-------SDEFLQ 195
Query: 1102 KKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYAS 1161
+ +K +K+ +I + +DD + FK+ + Q+K E +E
Sbjct: 196 SRKGQKKNQKNKPGPNIESGNEDDD------ASFKIKTVA--------QKKAEKKE---- 237
Query: 1162 DRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK 1221
R RK D++ + +K KE + KK++ +K ++K +E T K K
Sbjct: 238 -RERKKRDEEKAKLRKLKEKEELETG---------KKDQSKQKESQRKFEEETVKSKVTV 287
Query: 1222 DRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK---EKSDKEHSKERKSSR-SADAE 1277
D + ++++K + P AE + + K K K K EK +KE K++ S+ + A
Sbjct: 288 DTGVIPASEEKA---ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAM 344
Query: 1278 KSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRES 1337
+ L KL+EE + RE+ +++ +
Sbjct: 345 QEALAKLKEEEERQKREE-----------------------------------EERIKRL 369
Query: 1338 ACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFL 1397
L K KE+ER KK ++ER ++ K E K + +E +R E
Sbjct: 370 EELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARA-----EATLK 424
Query: 1398 EADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILK 1457
A GV K D L K ++ +K+ K + E SK++ + ++ +A+ ++
Sbjct: 425 LLQAQGVEVPSK----DSLPKKRPIYEDKKRKKIPQQLE-SKEVSESMEL--CAAVEVM- 476
Query: 1458 EKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDK 1517
E+ EK E E D GL D+ DE+ V ++
Sbjct: 477 EQGVPEKEETPPPVEPEEEEDTEDAGL-----DDWEAMASDEETEKVEGNKVHIEVKENP 531
Query: 1518 SRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKK-DARPREKLLG-- 1574
+E + + +E ++ E+ + + + ++KV+ KD GK D +P +++
Sbjct: 532 EEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDS 591
Query: 1575 --DGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLR 1612
D D T ER + IE+R H + + EKLR
Sbjct: 592 EYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNV-NTEKLR 630
Score = 99.4 bits (246), Expect = 4e-20
Identities = 152/687 (22%), Positives = 276/687 (40%), Gaps = 122/687 (17%)
Query: 733 REEKDRSNKAEKER-SLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEK 791
+++K++S + K+ L + + E KE+ +KSK + K +KK D ED I KE
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 792 EKI------FKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDL 845
E++ K D+E + + + +E+ +K++ + + K DD
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNE---EEFTSKDKKKKGQKGKKQSFDDN-------- 111
Query: 846 SDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVK---EDSKERRRDSRAREKRDYRE 902
DS + +D KS AK +E +D + +A+ K
Sbjct: 112 -------------DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSN 158
Query: 903 PFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERR 962
+ + D + NS+K KE++ + S E+G + + L+S K ++
Sbjct: 159 KKWDGSEED--EDNSKKIKERS---------------RINSSGESGDESDEFLQSRKGQK 201
Query: 963 DGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEK---KDGPDKER 1019
+ + E E ++ FK K+ K E ER R++EK + +KE
Sbjct: 202 KNQKNKPGPNIESGNE-DDDASFKIKTVAQ--KKAEKKERERKKRDEEKAKLRKLKEKEE 258
Query: 1020 KEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS 1079
E K ++ K+K S + E+++ K D +EK +T +D + DK++K
Sbjct: 259 LETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK-- 316
Query: 1080 LDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIA---DIFTDESEDDRDSCMGSGFK 1136
D+ K+K EK ++K+ KKG K+ A + + E++R K
Sbjct: 317 -DKKKKKGEKE---------EKEKEKKKGPSKATVKAMQEALAKLKEEEERQ-------K 359
Query: 1137 MGEASDLPRTDGLQ--EKEEGREAYASDRHRKSSDKQHPERQKDKE---PRDRRKDRGAA 1191
E + R + L+ KEE R +K +K+ ER K + + +R+ R A
Sbjct: 360 REEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARA 419
Query: 1192 DA----------------GRDKKEKVFEKHKEKK---DKESTEKYKDRKDRASVDSTQD- 1231
+A KK ++E K KK ES E + + A+V+ +
Sbjct: 420 EATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG 479
Query: 1232 --KKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEAL 1289
+K + P + E++ ED + + E +++ + ++ K E+ EEE
Sbjct: 480 VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEE 539
Query: 1290 HEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKER 1349
E ++ +++ E +S G E E D+K K +K+
Sbjct: 540 EEEEDEESEEEEEEEGESEGSEGDEE----------DEKVSDEKD------SGKTLDKKP 583
Query: 1350 HRHSSSSSKKSHDRERAKKEKAEKKEK 1376
+ SS S+ D +R K+E+A K K
Sbjct: 584 SKEMSSDSEYDSDDDRTKEERAYDKAK 610
Score = 87.0 bits (214), Expect = 2e-16
Identities = 149/699 (21%), Positives = 275/699 (39%), Gaps = 116/699 (16%)
Query: 293 EESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDED 352
+++ +E S ++D A ++ ++G AK EPQK+ K E + +
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGA-----------AKEQEPQKSKGKKKKEKKKQDF 53
Query: 353 DEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSD 412
DE D + +++ L + + + ++ + E + +K+ +K + D +D
Sbjct: 54 DEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDD-ND 112
Query: 413 EEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKR 472
E+ +K + GS + N +K K K +K KK E
Sbjct: 113 SEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDE--DN 170
Query: 473 SDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQ 532
S K + S ESG++ + L S K + P++ S S + AQ
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
Query: 533 KQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPV 592
K+ + K D K +++ L + T + D S + S
Sbjct: 231 KKAEKKERERKKR---DEEK-------AKLRKLKEKEELE-TGKKDQSKQKES------Q 273
Query: 593 RKRQEHRKRASLSEKKSPFLSSAEGA----VPKLDKEGKVVKKHKTKHKHKNKEKGQCSI 648
RK +E ++ ++ +S E A + D EG KK K K K + +EK
Sbjct: 274 RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK----- 328
Query: 649 SQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEK 708
E K+K ++ + + L LK + + K+EE+ +LEE
Sbjct: 329 -------------EKEKKKGPSKATVK---AMQEALAKLKEEEERQKREEEERIKRLEEL 372
Query: 709 EWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEER--K 766
E K+E+ L++ K K ++EK+R + +KE L KS +E + R + +
Sbjct: 373 EAKRKEEERLEQEKRERKK-----QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 767 KKSKDRPSK--LEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFL 824
+ + PSK L KK + EDK ++K+ ++ +E S E C + +
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDK-----------KRKKIPQQLESKEVSESMELCAAVEVM 476
Query: 825 -----ENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILE 879
E E+T + ++ + D D+ G D W++ +D K + K+ +E
Sbjct: 477 EQGVPEKEETPPPVEPEEEE----DTEDA-----GLDDWEAMASDEETEKVEG-NKVHIE 526
Query: 880 TVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDK 939
VKE+ +E + E+ D+ SE+ +E+ + + G E+D+
Sbjct: 527 -VKENPEEEEEEEEEEEE----------------DEESEEEEEEEGESEGSEG--DEEDE 567
Query: 940 KRRESAEAGR--DRKDALESCKERR----DGRAKPEEAH 972
K + ++G+ D+K + E + D R K E A+
Sbjct: 568 KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
Score = 84.0 bits (206), Expect = 2e-15
Identities = 113/485 (23%), Positives = 199/485 (41%), Gaps = 64/485 (13%)
Query: 1220 RKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKS 1279
++ S DST+D + L + E AA+++ K K K KE K+++ D K
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKE--KKKQDFDEDDILKE 61
Query: 1280 LLE-KLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGD---DKPR 1335
L E LE + + RE K +E + + FT + ++ + SF + + DK
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 1336 ESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRK-------- 1387
+S + E K + + K +K+ KK G + E S+K
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 1388 ---DSGQYEKDFLEADAYGVSYNMK----ADIE---DELDKTIELFSTEKKDKNDSEREP 1437
+SG +FL++ G N K +IE ++ D + ++ + +K ERE
Sbjct: 182 SSGESGDESDEFLQSRK-GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 1438 SKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHR 1497
K+ E++ K + LKEK++ E ++ +KE R +E ++
Sbjct: 241 KKRDEEKAK------LRKLKEKEELETGKKDQSKQKESQRK---------FEEETVKSKV 285
Query: 1498 DEQK---PATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVK------- 1547
PA+ +K P +D + GD K K+K K EKE+ + K
Sbjct: 286 TVDTGVIPASEEKAETPTAAEDDNE------GDKKKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 1548 ----MSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKE 1603
M K+ ++ K++ R K L + + ER+ +K +++ K KE
Sbjct: 340 TVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKE 399
Query: 1604 RMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKP-PGLDPPFKDKKLKESTPIPP 1662
R+K+ KL +S + +G+++P+K P P ++DKK K+ IP
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK---IPQ 456
Query: 1663 AAENK 1667
E+K
Sbjct: 457 QLESK 461
Score = 55.5 bits (132), Expect = 7e-07
Identities = 97/506 (19%), Positives = 195/506 (38%), Gaps = 42/506 (8%)
Query: 286 KGTYTSSEESSTESSEEEDAP------SFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKA 339
KG S + S E+ED S SS G+ +D EF + K + KN QK
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESD-EFLQSRKGQKKN---QKN 206
Query: 340 TAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAP 399
E ++DD ++ V K KK+ ++ + + K++ K +
Sbjct: 207 KPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ 266
Query: 400 KKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTR-------EPSNAKQQKEKN 452
K + + VTV TG ++P S+ + E N +K+K+
Sbjct: 267 SKQKESQRKFEEETVKSKVTVDTG---------VIPASEEKAETPTAAEDDNEGDKKKKD 317
Query: 453 KVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDP 512
K KKK +KE K +E + G S + E+ + E++R +K
Sbjct: 318 KKKKKGEKEEKEKEKKKGP-SKATVKAMQEALAKLKEEEERQKREEEERIK--------- 367
Query: 513 SLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTR 572
L A +++ ++ K K ++ + E + +++T
Sbjct: 368 -RLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTK-SQREARARAEATLKL 425
Query: 573 LTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKH 632
L ++ S+ +P+ + ++ +K E K S A ++ ++G V +K
Sbjct: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG-VPEKE 484
Query: 633 KTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRD 692
+T + +E+ + ++ + E K + +K + + E + + + + D
Sbjct: 485 ETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEED 544
Query: 693 HFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREE--KDRSNKAEKERSLKE 750
+EE+ + + E E +DEK + KD+ K + + +E D ++ +R+ +E
Sbjct: 545 EESEEEEEEEGESEGSEGDEEDEK-VSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEE 603
Query: 751 KSPKEEKLRLYKEERKKKSKDRPSKL 776
++ + K R+ K + KL
Sbjct: 604 RAYDKAKRRIEKRRLEHSKNVNTEKL 629
Score = 52.8 bits (125), Expect = 5e-06
Identities = 99/544 (18%), Positives = 216/544 (39%), Gaps = 49/544 (9%)
Query: 286 KGTYTSSEESSTESSEEEDAPSFAPSSS----VDGNNTDSEFEKGLKHKAKNPEPQKATA 341
KG S +++ +E E++D+ S + G++ D +F K L KAK + QK+
Sbjct: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK-LPKKAKG-KAQKSNK 159
Query: 342 PVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKK 401
+++ E+DE D + ++ + +S+ F+ K + K+ + N P
Sbjct: 160 ----KWDGSEEDE-DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKN--QKNKPGPN- 211
Query: 402 ASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKE 461
+ ++++DAS + T + + + E + ++ KEK +++ +K +
Sbjct: 212 -----IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ 266
Query: 462 TKGREV--RFGKRSDK---------FCSSESESESSESGEDDR--DSLGSSGCLKGSPLV 508
+K +E +F + + K +SE ++E+ + EDD D K
Sbjct: 267 SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE 326
Query: 509 LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDS 568
K+ S ++ + + A+ + + + R + + + E L
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR-KEEERLEQE 385
Query: 569 TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGA-VPKLD---K 624
R R + E E + ++E R RA + K L A+G VP D K
Sbjct: 386 KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK----LLQAQGVEVPSKDSLPK 441
Query: 625 EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYE-DSKQKSDKAILLENDLSTENK 683
+ + + K K + E + S S EL E K+++ + E + TE+
Sbjct: 442 KRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED- 500
Query: 684 LKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAE 743
D + +E+ K++ + K+ + ++ ++ EE++ ++E
Sbjct: 501 --AGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESE 558
Query: 744 KERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLK 803
E ++EK+ K+ K K ++ ++ D ++E+ + + K +++
Sbjct: 559 G----SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
Query: 804 KEKV 807
K ++
Sbjct: 615 KRRL 618
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 102 bits (253), Expect = 7e-21
Identities = 165/784 (21%), Positives = 316/784 (40%), Gaps = 88/784 (11%)
Query: 547 RTDNWKTISSPAWSEVSSLS-DSTRTRLTSESDY----SSEGSSVESLKPVRKRQEHRKR 601
+++ W + SE + ++ D+ R+ ++Y + + +E+LK + E R+R
Sbjct: 288 QSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLE-RQR 346
Query: 602 ASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEY 661
+ L ++ ++S + A+ +LD E + K + ++ ++ ++++ ++
Sbjct: 347 SELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLL 406
Query: 662 EDSKQKSDKAILLENDLSTENKLKVLKHDRDHFK--KEEKLSKMKLEEKEWLFKDEKSLK 719
E + + + S L + H K EEK+ ++ EKE + +E++
Sbjct: 407 EGEECRIGFGPI---PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT-- 461
Query: 720 RIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEK- 778
++ EE+++ +A++E +E+ +EE+ +EE K + + EK
Sbjct: 462 ----EETQVTEEVTEEEEK--EAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKE 515
Query: 779 -KNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQ 837
K+ +KE+ S + K ++++ K E E + K+ E + +
Sbjct: 516 AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA-------KSPAKEEAKSPPEAKSPE 568
Query: 838 RDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREK 897
++ + S + K + SP + + KS + AK E K KE A+
Sbjct: 569 KEE-----AKSPAEVKSPEKAKSPAKE--EAKSPAEAK-SPEKAKSPVKE-----EAKSP 615
Query: 898 RDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALES 957
+ + P + K+ EK K T++ P +K+ +S E + A
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675
Query: 958 CKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDK 1017
E+ K E E+ K S K+++ P + P +E+ K P+K
Sbjct: 676 SPEKAKSPVKAEAKSPEKAK-----SPVKEEAK-------SPEKAKSPVKEEAK--SPEK 721
Query: 1018 ERKEKTKPERYKEKSSDKDKSEKSILEKC---QKDKEFD-KCFKEKKDTKEKHKDTHGKD 1073
+ + + EK+ K E EK +K K D K + K KE+ + K
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF 781
Query: 1074 KERKASLDQGKEKKEKAFPGIISEDFS--EKKDDKKGKEKSWYIADIFTDESEDDRDSCM 1131
E+ S + + K + + ED EK+ KK + KS E E ++ +
Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS------PVKEEEKPQEVKV 835
Query: 1132 GSGFKMGEASDLPRTDGLQEKEEGREAYASDRHR---KSSDKQHPERQKDKEPRDRRKDR 1188
K E P T +EK++ ++ A + K +K+ P +K KE + K
Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895
Query: 1189 GAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEK-AEKKHA 1247
A D K+KV KE K ++ K++ V + K K P K AEKK A
Sbjct: 896 EAED-----KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 1248 AEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDS 1307
A +K +K +EK+ K K + +++ + +K+L +E S K + S
Sbjct: 951 APEKKDTK-EEKAKKPEEKPKTEAKAKEDDKTL-----------SKEPSKPKAEKAEKSS 998
Query: 1308 FTDR 1311
TD+
Sbjct: 999 STDQ 1002
Score = 94.4 bits (233), Expect = 1e-18
Identities = 170/796 (21%), Positives = 308/796 (38%), Gaps = 100/796 (12%)
Query: 902 EPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKK---RRESAEAGRDRKDALESC 958
E +FR + LD+ SE K T+ +S ++E ++ R EA + KD+LE
Sbjct: 290 EEWFRVR----LDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQ 345
Query: 959 KERRDGRAKPEEA-HREELKECGCE------------SGFKDKSDGDFGKGLE--PWERH 1003
+ + R + + A ++E +++ E ++D + +E + +
Sbjct: 346 RSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKL 405
Query: 1004 HPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTK 1063
E GP + P+ + K KSE+ I + +KE ++ ++T+
Sbjct: 406 LEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQ 465
Query: 1064 EKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDES 1123
+ T ++KE K ++GKE E+ E+++ + G+E++ + +
Sbjct: 466 VTEEVTEEEEKEAKE--EEGKE-----------EEGGEEEEAEGGEEETK------SPPA 506
Query: 1124 EDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRD 1183
E+ + + E + P EKEE + K+ E + E +
Sbjct: 507 EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAE 1243
K+ + A EK KE+ K E K ++ V + K P K E
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEA-KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 1244 KKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEV 1303
K AE K+ K K + KE +K + ++S + E++ K E+A + ++
Sbjct: 626 AKSPAEVKSPEKAKSPT-KEEAKSPEKAKSPEKEEA---KSPEKAKSPVKAEAKSPEKAK 681
Query: 1304 SSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDR 1363
S + E + E + + +E A PEK K + + KS +
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 1364 ERAKK-EKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIEL 1422
E AK EKA+ EK + + E+ AD + K+ +++E+ +
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF--PEKAKSPVKEEVKSPEKA 799
Query: 1423 FSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHAD 1482
S K+D E+E KK E + + +KE++K ++ + K +K A
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVK---------SPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850
Query: 1483 GLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEK 1542
+D + E+ P K++P +++K + ++K++ K K+ AE +K
Sbjct: 851 PKTEEKKDS-----KKEEAPK---KEAPKPKVEEKKEPAVEKPKESKVEAK-KEEAEDKK 901
Query: 1543 GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHK 1602
P +K AP+K K+DA+P+EK + + E + K
Sbjct: 902 KVPTP-----EKEAPAKVEVKEDAKPKEK-----------------TEVAKKEPDDAKAK 939
Query: 1603 ERMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPP 1662
E K EK KE A D +++ P +KP +D K P P
Sbjct: 940 EPSKPAEK----------KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989
Query: 1663 AAENKLHPASGADSKD 1678
AE K +S D KD
Sbjct: 990 KAE-KAEKSSSTDQKD 1004
Score = 92.8 bits (229), Expect = 4e-18
Identities = 169/779 (21%), Positives = 308/779 (39%), Gaps = 87/779 (11%)
Query: 705 LEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEE 764
L+ +EW L N D RS +EE E R L+ ++ + E L+ K+
Sbjct: 287 LQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEI-----TEYRRQLQARTTELEALKSTKDS 341
Query: 765 RKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKE-KLKKEKVYREDSAFDEYCNKNQF 823
+++ S+LE D + I+ +E I + D E + K ++ + + + N
Sbjct: 342 LERQR----SELE---DRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
Query: 824 LENEDTKFS--LSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETV 881
L+ E + L ++ F + S + G S V+ + +KS+ K+ V
Sbjct: 395 LDIEIAAYRKLLEGEECRIGFGPIPFSLPE--GLPKIPS-VSTHIKVKSEEKIKV----V 447
Query: 882 KEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKR 941
++ KE E+ E +++++ K E ++E+ + + G E++ K
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEA--KEEEGKEEEGGEEEEAEG--GEEETKS 503
Query: 942 RESAEAGRDRKDALESCKERRDGRAKPEEAHREELKE-CGCESGFKDKSDGDF------- 993
+ EA K+A KE A+ + +EE K +S K KS
Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 994 GKGLEPWERHHPAREK--EKKDGPDKERK----EKTKPERYKEKSSDKDKS----EKSIL 1043
K E E PA K EK P KE E PE+ K ++ KS + +
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK 623
Query: 1044 EKCQKDKEFDKCFKEKKDTKEKHKDTH---GKDKERKASLDQGK-------EKKEKAFPG 1093
E+ + E K K TKE+ K +KE S ++ K + EKA
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 1094 IISEDFSEKKDDKKGKE--KSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQE 1151
+ +E S +K KE KS A E + + + + ++ +E
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
Query: 1152 KEEGREAYASDRHR----KSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKE 1207
+ +A + ++ + KS + + P +++ + P D+ ++ + + K K
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Query: 1208 KKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE 1267
K+D ++ EK +K+ +++K Q++ K K A E+KA + K + K+ KE
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKEEEK-PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 1268 RKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTE 1327
+ +A K +E+ +E A+ + +E E + D+ + P
Sbjct: 863 EAPKK--EAPKPKVEEKKEPAVEKPKESK----VEAKKEEAEDKKKVP------------ 904
Query: 1328 PPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKK--EKAEKKEKGEDYKEGGS 1385
P + A ++KE + + + +KK D +AK+ + AEKKE + K+
Sbjct: 905 -----TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
Query: 1386 RKDSGQYEKDFLEADAYGVSYNM-KADIEDELDKTIELFSTEKKDKNDSEREPSKKIEK 1443
K EK EA A + K + + +K + ST++KD E+ K K
Sbjct: 960 EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 81.6 bits (200), Expect = 9e-15
Identities = 132/625 (21%), Positives = 246/625 (39%), Gaps = 78/625 (12%)
Query: 266 KGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEK 325
K E +KV +++ + T E TE EE+ + + E +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQT---EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495
Query: 326 GLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPK 385
G + + K+P ++A +P E E +++ P + K ++E KS + + P+
Sbjct: 496 GGEEETKSPPAEEAASP---EKEAKSPVKEEAKSPAE----AKSPEKEEAKSPAEVKSPE 548
Query: 386 MEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNA 445
+ KS K +P +A S +E + V + EK + A + + P+ A
Sbjct: 549 -KAKSPAKEEAKSPPEAK----SPEKEEAKSPAEVKSPEKAKSPAK-----EEAKSPAEA 598
Query: 446 KQ-QKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKG 504
K +K K+ VK++ K + + + S +E +S E + S
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAK-----SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
Query: 505 SPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSS 564
SP K+ + + S + S + ++P + + K + S
Sbjct: 654 SP--EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 565 LSDSTRTRLTSESDYSSEGSSVESLK-PVRKRQEHRKRASLSEK-KSPFLSSAEGAVPKL 622
+ + ++ ++S E + E K PV++ + ++A EK K+ + S E P
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP-- 769
Query: 623 DKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTEN 682
K+ K EK + + +E+K S +K+ K+ L E+ + E
Sbjct: 770 ------AKEEARSPADKFPEKAKSPVKEEVK----------SPEKA-KSPLKEDAKAPEK 812
Query: 683 KLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRS--N 740
++ + + K+EEK ++K++E ++EK+ K K S+ K +
Sbjct: 813 EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872
Query: 741 KAEKERSLKEKSPKEEKLRLYKEERKKK------SKDRPSKLEKKNDLKEDKISKEKEKI 794
K E+++ + PKE K+ KEE + K K+ P+K+E +KED KEK ++
Sbjct: 873 KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE----VKEDAKPKEKTEV 928
Query: 795 FKED----------KEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSD 844
K++ K KKE + +E K + E T+ +D +
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE--EKPKTEAKAKEDDK-----T 981
Query: 845 LSDSSFDFKGEDSWDSPVTDYRDMK 869
LS K E + S TD +D K
Sbjct: 982 LSKEPSKPKAEKAEKSSSTDQKDSK 1006
Score = 77.4 bits (189), Expect = 2e-13
Identities = 121/556 (21%), Positives = 228/556 (41%), Gaps = 72/556 (12%)
Query: 556 SPAWSEVSSLSDSTRTRLTSESDYSSEGSSVE-----SLKPVRKRQEHRKRASLSEKKSP 610
SP E +S ++ + E+ +E S E S V+ ++ + A K P
Sbjct: 503 SPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP 562
Query: 611 FLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDK 670
S E K E K +K K+ K + K + ++ K + E++K ++
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK----SPVKEEAKSPAEA 618
Query: 671 AILLENDLSTENKLKVLKHDRDHFKKEEKL-SKMKLEEKEWLFKDEKSLKRIKDTNKDIS 729
++ + + ++K + + K+E K K K EKE EK+ +K K
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS-- 676
Query: 730 RSFREEKDRSN-KAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKIS 788
EK +S KAE + K KSP +E+ + ++ + ++ S + K+ +KE+ +
Sbjct: 677 ----PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 789 KEKEKI-FKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSD 847
EK K KE+ + +K K + D +++ + K ++ R
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLD--------VKSPEAKTPAKEEAR--------- 775
Query: 848 SSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRK 907
S D K + SPV + ++KS AK +KED+K ++ +K + + P +
Sbjct: 776 SPAD-KFPEKAKSPVKE--EVKSPEKAK---SPLKEDAKAPEKE--IPKKEEVKSPVKEE 827
Query: 908 KDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAE-------AGRDRKDALESCKE 960
+ + +K + EK + P +KD K+ E+ + ++ A+E KE
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 961 RRDGRAKPEEAHREEL----KECGCESGFKD-----------KSDGDFGKGLEPWERHHP 1005
+ K E ++++ KE + K+ K + D K EP + P
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK---P 944
Query: 1006 AREKE----KKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKD 1061
A +KE KKD +++ K+ + + + K+ + DK+ K + +K ++KD
Sbjct: 945 AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004
Query: 1062 TKEKHKDTHGKDKERK 1077
+K K T K + K
Sbjct: 1005 SKPPEKATEDKAAKGK 1020
Score = 73.6 bits (179), Expect = 3e-12
Identities = 123/567 (21%), Positives = 225/567 (39%), Gaps = 62/567 (10%)
Query: 257 GGNPQQSNRKGE---TPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSS 313
GG + + E +P K A SP S E+ +S E +P A S +
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAK-SPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 314 VDGNNTDSEFEKGLKHKAKNP----EPQKATAPVKDEYEFDED---DEQDRVPPVDDKHL 366
+ + E + K +AK+P P+KA +P K+E + + E+ + P ++
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 367 ---LKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTG 423
K ++E KS + + P+ + KS TK +P+KA + E A V
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 424 EKLRLSAHTILPGSKTREPSNAKQQ-KEKNKVKKKRKKETKGREVRFGKRSDKFCSSESE 482
K A + + ++ + P AK KE+ K +K K K E + +++ E++
Sbjct: 674 AKSPEKAKSPVK-AEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAK 731
Query: 483 SESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQH 542
+ ++ SP K P +L S + + + ++P+ D+
Sbjct: 732 TPEKAKSPVKEEAK--------SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA--DKF 781
Query: 543 TKHWRTDNWKTISSP--AWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRK 600
+ ++ + + SP A S + + + + + + S E + V+ ++ +K
Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841
Query: 601 RASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYE 660
E+K+P E K K+ + KK K K + K++ +E K+++ E
Sbjct: 842 A---EEEKAPATPKTEEK--KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE 896
Query: 661 YEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKR 720
ED K KV +++ K E K +EK + K E +
Sbjct: 897 AEDKK-------------------KVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK 937
Query: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLE--- 777
K+ +K + + + K EK + +EK E K KE+ K SK+ PSK +
Sbjct: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA---KEDDKTLSKE-PSKPKAEK 993
Query: 778 -KKNDLKEDKISKEKEKIFKEDKEKLK 803
+K+ + K SK EK ++ K K
Sbjct: 994 AEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 52.8 bits (125), Expect = 5e-06
Identities = 111/561 (19%), Positives = 193/561 (34%), Gaps = 73/561 (13%)
Query: 126 EESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIK 185
E+ A SPV K P+++ +K S ++ K ++ E + K
Sbjct: 513 EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE---K 569
Query: 186 ELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNG 245
E A+V + A A EA + ++ + E + +P+ + A
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA--- 626
Query: 246 HYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDA 305
+S + ++P K A SPT K S E++ + EE +
Sbjct: 627 ----------------KSPAEVKSPEK-AKSPT-------KEEAKSPEKAKSPEKEEAKS 662
Query: 306 PSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKH 365
P A S + + + +K +AK+PE KA +PVK+E + E +
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPE--KAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 366 LLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEK 425
K ++E K+ + KS K +P+KA + T D + E+
Sbjct: 721 KAKSPVKEEAKTPE-------KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 426 LRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESES 485
R A K + P ++ K K K K++ K E K+ + + E +
Sbjct: 774 ARSPADKF--PEKAKSPVK-EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Query: 486 SESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKH 545
E + +P + S A +K+ P + K
Sbjct: 831 QEVKVKEPPKKAEEEKAPATP-----------KTEEKKDSKKEEAPKKEAPKPKVEEKKE 879
Query: 546 WRTDNWKTISSPAWSEVSSLSDSTRTRL---TSESDYSSEGSSVESLKPVRKRQEHRKRA 602
+ P S+V + + + T E + ++ E KP K + +K
Sbjct: 880 ------PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 603 SLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYE 662
++ K P + + K+ K K K + K K + K K T E
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA--------KEDDKTLSKE 985
Query: 663 DSKQKSDKAILLENDLSTENK 683
SK K++KA E ST+ K
Sbjct: 986 PSKPKAEKA---EKSSSTDQK 1003
Score = 52.0 bits (123), Expect = 8e-06
Identities = 103/510 (20%), Positives = 175/510 (34%), Gaps = 83/510 (16%)
Query: 1888 AKPSPSPRAELLVPSLEGALPPDLDTS---EDQQATAAIIPPEPSYLEPLDEGPFSAVIT 1944
A+ + SP E P E A P S E+ ++ A + PE + +E
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA------- 558
Query: 1945 EEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAA 2004
+ P E P ++ S + E S P + + + PE K P+ A
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPEKAK-----SPVKEEA 612
Query: 2005 PGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLES 2064
P +EA P + +P + E K+ + A S + +P
Sbjct: 613 KSP---AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 2065 FFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAF 2124
+ KS PE A P A + +A P++ + S P +
Sbjct: 670 VKAEAKS-PEK----AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS--------PVKEEA 716
Query: 2125 AGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVINGGDVSTVVA 2184
PE + K EA+ E++ +P +E + T+
Sbjct: 717 KSPE---------------KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 2185 EEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGD----PDSSVE 2240
+ P A P + R PA+ PE + P + +++ +A++ +E A+ P
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSP-VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 2241 PAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAA 2300
+PV E++P Q + + PP A + AP T + D E
Sbjct: 821 KSPVKEEEKP-----QEVKVKEPPKK---AEEEKAPATPKTEEKKDSKKEE--------- 863
Query: 2301 APAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPP----PSE 2356
P+ PKP E K P VE+ + + + ++ K P P++
Sbjct: 864 ----------APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 2357 KECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386
E P + + E DDA+A+ P K
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSK 943
Score = 45.4 bits (106), Expect = 7e-04
Identities = 98/497 (19%), Positives = 183/497 (36%), Gaps = 86/497 (17%)
Query: 8 KAPQQEEL--PLSSDMVEKQTG--KKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFT 63
K+P +EE P + EK K++ + K+P E EV+ K K P
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS-PEKAKSPTK 643
Query: 64 AGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQM 123
A +K EK+ + K PV +A S ++A E+ + + +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP-EKAKSPVKAEAKSPEKAKSPVKEEA 702
Query: 124 TAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARR 183
+ E A SPV K P ++ K +KT +K K + E + A + +
Sbjct: 703 KSPEKAKSPVKEEAKSPEKA----KSPVKEEAKTPEKA-KSPVKEEAKSPEKAKSPEKAK 757
Query: 184 IKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAAN 243
++ S A K+ A A + + AK + + K +PL + A
Sbjct: 758 TLDVKSPEAKTPAKEEARSPA------DKFPEKAKSPVKEEVKSPEKA---KSPLKEDAK 808
Query: 244 NGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEE 303
++ K + ++P+K P V + + + +EEE
Sbjct: 809 APEKEIPK------------KEEVKSPVKEEEKPQEVKV-----------KEPPKKAEEE 845
Query: 304 DAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV-------KDEYEFDEDDEQD 356
AP+ + DS+ E+ K +A P+ ++ P K E + +E +++
Sbjct: 846 KAPATPKTE----EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKK 901
Query: 357 RVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDA 416
+VP + + K + +++ K + K E P A + S +++++A
Sbjct: 902 KVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE-----------PDDAKAKEPSKPAEKKEA 950
Query: 417 SVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKF 476
+ P K + AK+ +EK K + K K++ K K K
Sbjct: 951 A-----------------PEKKDTKEEKAKKPEEKPKTEAKAKEDDK----TLSKEPSKP 989
Query: 477 CSSESESESSESGEDDR 493
+ ++E SS +D +
Sbjct: 990 KAEKAEKSSSTDQKDSK 1006
Score = 38.1 bits (87), Expect = 0.12
Identities = 50/225 (22%), Positives = 86/225 (38%), Gaps = 26/225 (11%)
Query: 2174 INGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLD---VALEAAVEAETVPEER 2230
I G + + E P +P ST + + E + K + V +E E V EE
Sbjct: 413 IGFGPIPFSLPEGLPKIP--SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEV 470
Query: 2231 ARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEG-------PPAASLCAPDGPAPNTVAQAQ 2283
+ + E E+ G + EAEG PPA +P+ A + V +
Sbjct: 471 TEEEEKEAKE------EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA 524
Query: 2284 AADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQM 2343
+ + E +++ A + P P E K EA K+P EE ++ A++
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA-KSPEKEE-----AKSPAEV 578
Query: 2344 LANQSKQGPPPSEKECAPTPAPVTRAKARGSED--DDAQAQHPRK 2386
+ + + P E + +AK+ E+ A+A+ P K
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK 623
Score = 36.6 bits (83), Expect = 0.34
Identities = 39/162 (24%), Positives = 69/162 (42%), Gaps = 20/162 (12%)
Query: 7 PKAPQQEELPLSSDMVEKQTGKKD--------KDKVSLTKTPKLERGDGGKEVRERASKR 58
PK ++E+ P + EK+ KK+ K KV K P +E+ KE + A K
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK---PKESKVEAKKE 895
Query: 59 KLPFTAGANGEQKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPL--SERQQ 116
+ A ++K EK+ P + +K++ ++ + +A P +E+++
Sbjct: 896 E------AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949
Query: 117 VALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTK 158
A + T EE A P + PK +++ K SK K
Sbjct: 950 AAPEKKDTKEEKAKKP-EEKPKTEAKAKEDDKTLSKEPSKPK 990
>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
Length = 1058
Score = 101 bits (252), Expect = 9e-21
Identities = 63/136 (46%), Positives = 79/136 (58%), Gaps = 5/136 (3%)
Query: 146 CQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELIS-EGADVNVKDFAGWTA 204
C K S K K +K N +GET LHRA I ++ L+S G D+NVKD AGWT
Sbjct: 786 CSKENCPSVVK-KMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTP 844
Query: 205 LHEACNRGYYDVAKQLLAAGAEVN-TKGLDDDTPLHDAANNGHYKVVKLLLRYGGNP--Q 261
LHEACN G +++L EV+ +D TPLHDA +NGH ++ KLLL++GG Q
Sbjct: 845 LHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQ 904
Query: 262 QSNRKGETPLKVANSP 277
Q N KGE PL SP
Sbjct: 905 QRNAKGELPLDYVVSP 920
Score = 33.9 bits (76), Expect = 2.2
Identities = 32/169 (18%), Positives = 76/169 (44%), Gaps = 29/169 (17%)
Query: 674 LENDLSTENKLKVLKHDRDH----FKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDIS 729
++ND ++ +H + F+K+ +MK +E +++ +K ++ +D N
Sbjct: 201 IQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRETMYRTQKEMQNHEDVNVGSI 260
Query: 730 RSFREEKDRSNKAEKE---------------RSLKEKSPKEEKLRLYKEERKKKSKDRPS 774
+K++ + + K+ + KE K+E ++ R+K+ K + S
Sbjct: 261 LIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKKDEDIQRSYTLRRKRKKGKES 320
Query: 775 KLEKKNDLKEDKI-SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ 822
+K ++ +KI S + I+ D++++K +S F EY +++
Sbjct: 321 NCKK--GVEHEKIKSTLRRHIYNRDQKEMK-------NSIFAEYAKESK 360
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 99.4 bits (246), Expect = 4e-20
Identities = 172/854 (20%), Positives = 354/854 (41%), Gaps = 111/854 (12%)
Query: 623 DKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTEN 682
D E + ++ + + + + + Q +E L T + E + Q S + E +T
Sbjct: 32 DDEEEAARERRRRARQERLRQKQ----EEESLGQVTDQVEVNAQNS---VPDEEAKTTTT 84
Query: 683 KLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKA 742
+V D F E+L++ + ++ L + + K T D S S + +++ A
Sbjct: 85 NTQVEGDDEAAFL--ERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 142
Query: 743 EKERSLKEKSP--KEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKE 800
E E + KE+ ++E+ + + E KS + + + + KEDK +E E++E
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE------EEEE 196
Query: 801 KLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDS 860
K K+ + N+ + + E T ++ Q + L + G+ S +
Sbjct: 197 KPKRGSIGE---------NQVEVMVEEKT----TESQEETVVMSLKN------GQISSEE 237
Query: 861 P-VTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
P + R+ SD ++ E ++E+ KER RAR + + RE ++D+ D+ +
Sbjct: 238 PKQEEEREQGSDEISH--HEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA-- 293
Query: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKEC 979
R E EK + ++++RRE+ E R R++ + +ER+ R K EE E ++
Sbjct: 294 RIEAEEK-------AAAQERERREAEERERMREEEKRAAEERQ--RIKEEEKRAAEERQ- 343
Query: 980 GCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKER-KEKTKPERYKEKSSDKDKS 1038
+E+EK+ +++R KE+ K + + + ++
Sbjct: 344 -------------------------RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
Query: 1039 EKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS---LDQGKEKKEKAFPGII 1095
EK+ +E+ +++K+ ++ ++TK K G+ E+K +++ K +++K ++
Sbjct: 379 EKAKVEEQKRNKQLEEKKHAMQETKIK-----GEKVEQKIEGKWVNEKKAQEDKLQTAVL 433
Query: 1096 SEDFSEKKDDKKGK-EKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEE 1154
+ EK + K EK F E D K S + R G E +
Sbjct: 434 KKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 493
Query: 1155 GREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKEST 1214
+ + H+ + R + D ++ GA K+ + + + + + E
Sbjct: 494 QNGEFMT--HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 551
Query: 1215 EKYKDRKDRASVDSTQDKKNKQKLPE--KAEKKHAAEDKAKSKHKEKSDKEHSKERKSSR 1272
EK K ++ A+++ + KK +++ + + E++ +++A K +E+ +K KE R
Sbjct: 552 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 611
Query: 1273 SADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDD 1332
A+A + +K+ E+ L + ++ + SS +R + FL S + G
Sbjct: 612 RAEAAEK-RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE------FLNKSVQKSSGVK 664
Query: 1333 KPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQY 1392
++A + + E++ + +K + + A + E G R +
Sbjct: 665 STHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAE--------GVRNIKSMW 716
Query: 1393 EKD--FLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGS 1450
EK F A G A ++ + I + T+ D N S P+ K +L+P
Sbjct: 717 EKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKS---PAPK-PSDLRPGDV 772
Query: 1451 SAINILKEKKKREK 1464
S+ L EK+ +K
Sbjct: 773 SSKRNLWEKQSVDK 786
Score = 96.7 bits (239), Expect = 3e-19
Identities = 144/685 (21%), Positives = 296/685 (43%), Gaps = 115/685 (16%)
Query: 882 KEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKR 941
+E ++ERRR +R R +E + D ++ N++ SVP E
Sbjct: 35 EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN---------SVPD--EEAKTTT 83
Query: 942 RESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWE 1001
+ G D LE R + R K + E KE D + D L
Sbjct: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF-------DPTITDASLSLPSRR 136
Query: 1002 RHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKD 1061
+ E E + KE K +++ ERY+ + ++ ++ + QK+ + +D
Sbjct: 137 MQNDTAENETTE---KEEKSESRQERYEIEETE------TVTKSYQKN--------DWRD 179
Query: 1062 TKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK-------SWY 1114
+E K+ DKE++ +E++EK G I E+ E ++K E S
Sbjct: 180 AEENKKE----DKEKE------EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
Query: 1115 IADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPE 1174
I ++E + + + GS ++ + ++E+++ R A A ++ +++ +
Sbjct: 230 NGQISSEEPKQEEEREQGS-------DEISHHEKMEEEDKER-AEAERARLEAEERERIK 281
Query: 1175 RQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKN 1234
++DK+ D R A + +EK + +E+++ E E+ ++ + RA+ + + K+
Sbjct: 282 AEQDKKIADER-------ARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE 334
Query: 1235 KQKLPE-----KAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLE-----KL 1284
+++ E K E+K AAE++ + K +EK E ER+ +R+ + EK+ +E K
Sbjct: 335 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE---ERQRARAEEEEKAKVEEQKRNKQ 391
Query: 1285 EEEALHEYRED--SNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPE 1342
EE H +E +K+ + + + ++ L+ + + G++K + E
Sbjct: 392 LEEKKHAMQETKIKGEKVEQKIEGKWVN--EKKAQEDKLQTAVLKKQGEEKGTKVQAKRE 449
Query: 1343 KLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGE--DYKEGGS--RKDSGQY------ 1392
KL+E + + K+ E+ KK+K K+E D K+G + + +G++
Sbjct: 450 KLQEDK-----PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 504
Query: 1393 --EKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGS 1450
E F +A+ +++ L ++ + ++E E +K++++ +
Sbjct: 505 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-RGETESEEFEKLKQKQQ---E 560
Query: 1451 SAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSP 1510
+A+ + + KKKRE+ R+ +E++R + AD LR +E+K +++
Sbjct: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLR----------EEEEKRRLKEEIER 610
Query: 1511 PRVLKDKSRDEGPRLGDAKLKEKFK 1535
R + R + P G + K+ FK
Sbjct: 611 RRAEAAEKRQKMPEDGLSDDKKPFK 635
Score = 84.0 bits (206), Expect = 2e-15
Identities = 116/546 (21%), Positives = 235/546 (43%), Gaps = 73/546 (13%)
Query: 553 TISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFL 612
++S P+ + +++ T +S+ E +E + V K + E K
Sbjct: 129 SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK---- 184
Query: 613 SSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQE----------LKLKSFTYEYE 662
K DKE + ++ K K + + + + ++ + LK+ E
Sbjct: 185 --------KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE 236
Query: 663 DSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIK 722
+ KQ+ ++ +++S K++ + D + E + ++++ EE+E + ++ K+I
Sbjct: 237 EPKQEEERE-QGSDEISHHEKME----EEDKERAEAERARLEAEERERIKAEQD--KKIA 289
Query: 723 DTNKDIS---RSFREEKDRSNKAEKERSLKE-KSPKEEKLRLYKEERKKKSKDRPSKLEK 778
D I ++ +E++R E+ER +E K EE+ R+ +EE++ + + K E+
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 779 KNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLEN-----EDTKF-- 831
K +E + KE+EK E++++ + E+ E+ A E +N+ LE ++TK
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEE---EEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Query: 832 -SLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKED----SK 886
+ +W ++ ED + V + + + + E ++ED K
Sbjct: 407 EKVEQKIEGKWVNEKKAQ------EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 887 ERRRDSRAREKRDYREPF--FRKKDRDYLDKNSEKRKEQTEKHK------SVPGYLSEKD 938
E +D + ++ ++ +E F + + + + S+ + T K K S PG + D
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
Query: 939 KKRRESA---EAGRDRKDALESCKERRDGRAKPEEAH--REELKECGCESGFKDKSDGDF 993
K E A EAG+ LE + RR G + EE +++ +E E K +
Sbjct: 521 TKEAEGAPQVEAGK----RLEELRRRR-GETESEEFEKLKQKQQEAALELEELKKKREER 575
Query: 994 GKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFD 1053
K LE E+ E ++K ++E K + K E + ++ +K +K + DK+
Sbjct: 576 RKVLEEEEQRRKQEEADRK-LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 634
Query: 1054 KCFKEK 1059
KCF K
Sbjct: 635 KCFTPK 640
Score = 82.4 bits (202), Expect = 5e-15
Identities = 101/516 (19%), Positives = 205/516 (39%), Gaps = 43/516 (8%)
Query: 1162 DRHRKSSDKQHPERQKDKEPR---------DRRKDRGAADAGRDKKEKVFEKHKEKKDKE 1212
+ R+ ++ ERQK+ +P RR A+ +KE+ E +E+ + E
Sbjct: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
Query: 1213 STEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSR 1272
TE + ++ K + K E+ E++ E +E + E +
Sbjct: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223
Query: 1273 SADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDD 1332
+ K+ EE E RE +D+IS D+ + A LE E +
Sbjct: 224 VVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE 283
Query: 1333 KPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQY 1392
+ ++ A +++ +E+ +++ +RER ++E+ E+ + KE R +
Sbjct: 284 QDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 1393 EKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSA 1452
E A +K + + ++ + E++ E++ +K++E++ +
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETK 403
Query: 1453 INILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPR 1512
I K +K +K KW +EK+ D+ +L+ +E + +++ DK P
Sbjct: 404 I---KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK---PT 457
Query: 1513 VLKDKSRDEGPRLGDAKLKEKFKDGAEKEKG-DPVKMSNGNDKVAPSKDPGKKDARPREK 1571
K++ +DE + D + KE+ K +++KG VK NG K +RP +
Sbjct: 458 FKKEEIKDEKIKK-DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 516
Query: 1572 LLGD-----------------------GDLMMTSFERMLSQKD---LEIEERHKRHKERM 1605
D G+ FE++ ++ LE+EE K+ +ER
Sbjct: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576
Query: 1606 KQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKK 1641
K +E+ R + K + ++ R+ +I ++
Sbjct: 577 KVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 612
Score = 65.9 bits (159), Expect = 5e-10
Identities = 118/651 (18%), Positives = 254/651 (39%), Gaps = 84/651 (12%)
Query: 331 AKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
A+N P + + + DDE + + L +++ R++ + + K +
Sbjct: 70 AQNSVPDEEAKTTTTNTQVEGDDEAAFL-----ERLARREERRQKRLQEALERQKEFDPT 124
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKE 450
T + P + ++ E + E+ + + S + N + E
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK---NDWRDAE 181
Query: 451 KNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLK 510
+NK + K K+E + + + G + E +++ES E+
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE------------------- 222
Query: 511 DPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTR 570
++ SL SS +++ +D+ + H + + E +++ R
Sbjct: 223 --TVVMSLKNGQISSE-EPKQEEEREQGSDEISHHEKME----------EEDKERAEAER 269
Query: 571 TRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVK 630
RL +E + + + R R E ++A+ E++ E ++ +E K +
Sbjct: 270 ARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE----RMREEEK--R 323
Query: 631 KHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHD 690
+ + + K +EK Q +K E E + + I E + E + + +
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIK------EEEKRAAEERQRIKEEEKRAAEERQRARAEE 377
Query: 691 RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKE 750
+ K EE+ +LEEK+ ++ K +K K K + E+K + +K + +
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETK-IKGEKVEQKIEGKWVNEKKAQEDKLQ---TAVL 433
Query: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYRE 810
K EEK + +R+K +D+P+ KK ++K++KI K+KE KE+ + K
Sbjct: 434 KKQGEEKGTKVQAKREKLQEDKPT--FKKEEIKDEKIKKDKEP--KEEVKSFMDRK---- 485
Query: 811 DSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKS 870
F E ++N K + + R + + + + + + R +
Sbjct: 486 -KGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
Query: 871 DSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSV 930
++ ++ E +K+ +E + +K+ R++ R L++ ++RK++ K
Sbjct: 545 ETESE-EFEKLKQKQQEAALELEELKKK-------REERRKVLEEEEQRRKQEEADRK-- 594
Query: 931 PGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGC 981
L E+++KRR E R R +A E ++ PE+ ++ K C
Sbjct: 595 ---LREEEEKRRLKEEIERRRAEAAEKRQK------MPEDGLSDDKKPFKC 636
Score = 34.3 bits (77), Expect = 1.7
Identities = 78/369 (21%), Positives = 146/369 (39%), Gaps = 59/369 (15%)
Query: 29 KDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQKDSDTEKQGPERKRIKKE 88
++++++ + K+ E E+A+ ++ E+ + ++ ER+RIK+E
Sbjct: 275 EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE 334
Query: 89 PVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQK 148
++A ERQ++ + AEE + K ++ Q+
Sbjct: 335 --EKRAA----------------EERQRIKEEEKRAAEE--RQRIKEEEKRAAEER--QR 372
Query: 149 GTPNSASKTKDKVNKRNERGETRLH---RAAIRGDARRIKELISEGADVNVKDFAGWTAL 205
K K + KRN++ E + H I+G+ ++++ I EG VN K A L
Sbjct: 373 ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE--KVEQKI-EGKWVNEKK-AQEDKL 428
Query: 206 HEACNRGYYDVAKQLLAAGAEVNTK--GLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQ- 262
A + KQ G +V K L +D P K+ K P++
Sbjct: 429 QTAV------LKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK-----DKEPKEE 477
Query: 263 -----SNRKGETPLKVANSPTMVNLLL-GKGTYT-SSEESSTESSEEEDAPSFAPSSSVD 315
+KG T +K N M + L + T++ +S ++ E E AP ++
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 537
Query: 316 ------GNNTDSEFEKGLKHKAKNP--EPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLL 367
G EFEK LK K + E ++ ++ + E++EQ R D+ L
Sbjct: 538 ELRRRRGETESEEFEK-LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 596
Query: 368 KKDYRKETK 376
+++ ++ K
Sbjct: 597 EEEEKRRLK 605
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 98.2 bits (243), Expect = 9e-20
Identities = 198/910 (21%), Positives = 342/910 (37%), Gaps = 122/910 (13%)
Query: 437 SKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSL 496
SK +E NA + NK KK RK+ KG E + +S E + E+ DSL
Sbjct: 882 SKEKESENAPGDGKGNKHKKHRKRR-KGEESEGFLNPELLETSRKSREPTGVEENKTDSL 940
Query: 497 GSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISS 556
+ V +P S++ S S ++ P TK R ++ +S
Sbjct: 941 FVLPSRDDATPVRDEPMDAESITFKSVSE--KDKRERDKPKAKGDKTK--RKNDGSAVSK 996
Query: 557 PAWSEVSSLSDSTRTRLTSESDYSSEGSS-VESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
+ + + ++ E + S ++ K + ++ K +S S+K +
Sbjct: 997 K--ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1054
Query: 616 EGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLE 675
A K KE + K K +EK + S+++K + T + E +K+ ++K L+
Sbjct: 1055 RKAHSKSAKEHQETKPVK-------EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD 1107
Query: 676 ND-LSTENKLKVLKHDRDHFKKEEKLSKMKLEE------KEWLFKDEKSLKRIKDTNKDI 728
N + K + D+D K+SK+++ E K + D + + R + +K I
Sbjct: 1108 NKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDK-I 1166
Query: 729 SRSFREEKDRSNK--------AEKERSLKEKSPKEEKL--RLYKEERKKKSKDRPSKLEK 778
S S +K + N+ E + KE S K E ++ +E+ K K + + + E
Sbjct: 1167 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1226
Query: 779 KNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQF--------------- 823
+ D S K + K + +EY N N
Sbjct: 1227 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1286
Query: 824 LENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKE 883
+ +D + D + + S + + K + S + Y + +S+ K I + K+
Sbjct: 1287 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK-IQKFTKD 1345
Query: 884 DSKERRRDSRAREKRDYREPFFRKKDRDY--LDK-NSEKRKEQTEKHKSVP--------- 931
S E + K + KDRDY L+K N EKRK T+ K
Sbjct: 1346 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGN 1405
Query: 932 -GYLSEKDKKRRESAEAGRDRKDALESCKERRDGR----------AKPEEAHREELKECG 980
LS+ K+ R S + R + + RD + +K + E +
Sbjct: 1406 FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1465
Query: 981 CESGFKDKSDGDFGKGLEPWERHHPAR----EKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
S KD + G K E ER P + K+ P ++RK Y K +++
Sbjct: 1466 SPSRNKDSASGQKNKPRE--ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1523
Query: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKH----------KDTHGKDKERKASLDQG--K 1084
KS+ + KD+E K E ++ KE +T + ++ +D+ K
Sbjct: 1524 T--KSVDKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1579
Query: 1085 EKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLP 1144
K + + +S D + + D+ A D +E D +S + K E+S
Sbjct: 1580 PKPQLSHSSRLSSDLTRETDE----------AAFEPDYNESDSESNVS--VKEEESSGNI 1627
Query: 1145 RTDGLQEK--EEGREAY---------ASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADA 1193
D L++K E+ +E+ S SS P R R +A +
Sbjct: 1628 SKD-LKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1686
Query: 1194 GRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
+ K +K KEKK + +K+K K A + +K K K +K KK +K K
Sbjct: 1687 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK----NKDK 1742
Query: 1254 SKHKEKSDKE 1263
K KEK D++
Sbjct: 1743 EKEKEKDDQK 1752
Score = 87.8 bits (216), Expect = 1e-16
Identities = 229/1214 (18%), Positives = 441/1214 (36%), Gaps = 143/1214 (11%)
Query: 505 SPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVS- 563
+P L P + S + + +++ ++ A + + + + ++ S ++S S
Sbjct: 607 APANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSPYSGSSYSRSSY 666
Query: 564 ----SLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
S S STR+R S S S S P +R + R S +S +
Sbjct: 667 TYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRS 726
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
P + + ++ + + + ++ Q + + Y + D +
Sbjct: 727 PPYRRYHS---RSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVD 783
Query: 680 TENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRS 739
RD F+KE + + + + +EW K K +R +R
Sbjct: 784 F----------RDPFEKE-RYREWERKYREWYEKYYKGYAAGAQPRPSANRE-NFSPERF 831
Query: 740 NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN--DLKEDKISKEKEKIFKE 797
S + +E+ + + + P KL ++ + K++ SKEKE
Sbjct: 832 LPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAP 891
Query: 798 DKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDS 857
K K K +R+ +E FL E + S + + +DS F D
Sbjct: 892 GDGKGNKHKKHRKRRKGEE---SEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDD 948
Query: 858 WDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS 917
T RD D+ + ++D +ER + +K + ++ + K +
Sbjct: 949 ----ATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPA 1004
Query: 918 EKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELK 977
+ +E+ + + KK +E + K + S K+ + P +AH + K
Sbjct: 1005 KGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKI-TGTPRKAHSKSAK 1063
Query: 978 ECGCESGFKD-KSDGDFGKGLEPWE---RHHPAREKEKKDGPDKERKEKTKPERYKEKSS 1033
E K+ K D+ K ++ + + A++ +K+ P + EK K + +EK
Sbjct: 1064 EHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK-RKTEEKGV 1122
Query: 1034 DKDKSEKSI----------------------LEKCQKDKEFDKCFKEKKDTKEKHKDTHG 1071
DKD S+ EK + E DK K K G
Sbjct: 1123 DKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1182
Query: 1072 KDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCM 1131
K ++ KE EK + S K++ KGK + + + D S
Sbjct: 1183 KKIGSTENISNTKEPSEK----LESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTS 1238
Query: 1132 GSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDK----QHPERQKDK-----EPR 1182
+G S+ +TD + + E Y +D + D Q P+ + DK E
Sbjct: 1239 STGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEE 1297
Query: 1183 DRRKDRGAADAGR--------DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKN 1234
D + + + G+ K K+ EK+ + S + K KD S + Q +
Sbjct: 1298 DVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD-VSHEIIQHEV- 1355
Query: 1235 KQKLPEKAEKKHAAEDKAKSKHKEKS--DKEHSKERKSSRSADAEKSL--------LEKL 1284
K+ K A+ +K K+K ++ S +KE+ ++RK+S + E +L + L
Sbjct: 1356 ------KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSL 1409
Query: 1285 EEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKL 1344
+ + D +D S+ FT + + D + S+ ++
Sbjct: 1410 SQSSKEARTSDKHDSTRASSNKDFTPNRDK------------KTDYDTREYSSSKRRDEK 1457
Query: 1345 KEKERHRHSSSSSKKSHDRERAK-KEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYG 1403
E R + S S +K S ++ K +E+ + +KG G S+K + +D D +
Sbjct: 1458 NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT----GDSKKSNSSPSRDRKPHD-HK 1512
Query: 1404 VSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKR- 1462
+Y+ K E+ K+++ + ++K+ E +K+ G+ + IL + +
Sbjct: 1513 ATYDTKRPNEET--KSVDKNPCKDREKHVLEARNNKESS------GNKLLYILNPPETQV 1564
Query: 1463 EKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQ-KPATRDKDSPPRVLKDKSRDE 1521
EK + + +K + + +L R + +P + DS V +
Sbjct: 1565 EKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1624
Query: 1522 GPRLGDAK------LKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGD 1575
G D K KE A + G S+ + V+PS+ ++ R
Sbjct: 1625 GNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSA 1684
Query: 1576 GDLMMTSFERMLSQKDLEIEERHKRHKERMK---------QMEKLRH---RSGDPKLKEK 1623
++ +K+ + ++HK+HK+ K + +K +H +S K KEK
Sbjct: 1685 SSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEK 1744
Query: 1624 AKPADDGRKKGLDI 1637
K DD + K + +
Sbjct: 1745 EKEKDDQKVKSVTV 1758
Score = 82.8 bits (203), Expect = 4e-15
Identities = 167/840 (19%), Positives = 306/840 (36%), Gaps = 128/840 (15%)
Query: 286 KGTYTSSEESSTESSEEEDA--PSFAPSSSVDGNNTDSEFEKGLKHKAKNPEP------- 336
KG T + + S++E+ P+ P VDG S + KAK P
Sbjct: 981 KGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS 1040
Query: 337 -------QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVK 389
+K T + + + Q+ P ++K +KKDY K+ KS + + K
Sbjct: 1041 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK--VKKDYSKDVKSEKLTTKEEKAKK 1098
Query: 390 SYTKNNTIAPKKASHRILSD----TSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNA 445
KN + K + ++ D E +S+ + +L I+ S R+
Sbjct: 1099 PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKIS-----KLEVTEIVKPSPKRKMEPD 1153
Query: 446 KQQKEKNKVKKKRKKETKGREVRFGKRS-DKFCSSESESESSESGE--DDRDSLGSSGCL 502
++ ++ K K ++++ + + K S+E+ S + E E + S +
Sbjct: 1154 TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKV 1213
Query: 503 KGS---PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAW 559
KG + + S + + +STSS G S +K + T + + ++
Sbjct: 1214 KGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA 1273
Query: 560 SEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
+V + +++ + D+ SE V+S +P +
Sbjct: 1274 EDVIIMIQVPQSK-WDKDDFESEEEDVKSTQP---------------------------I 1305
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
+ K V+K TK + K E + S+K D+S
Sbjct: 1306 SSVGKPASVIKNVSTKPSNIVKYP------------------EKESEPSEKIQKFTKDVS 1347
Query: 680 TENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRS 739
E +++H+ K K K +++++ ++++ ++ K++ + S DR
Sbjct: 1348 HE----IIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKES---NLDRL 1400
Query: 740 NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDK 799
N+ +SL + S + + R +KD +KK D + S K + K +
Sbjct: 1401 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1460
Query: 800 EKLKKEKVYREDSAFDEYCNKNQFLENE--------DTKFSLSDDQRDRWFSDLSDSSFD 851
+ K +DSA + KN+ E D+K S S RDR D +++D
Sbjct: 1461 TRRKDSPSRNKDSASGQ---KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYD 1516
Query: 852 FKGED------------SWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRD 899
K + + V + R+ K S KL+ +++ + + +
Sbjct: 1517 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1576
Query: 900 YREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKD-------KKRRESAEAGRDRK 952
+P K + + S +T++ P Y +E D K+ S +D K
Sbjct: 1577 TVKP---KPQLSHSSRLSSDLTRETDEAAFEPDY-NESDSESNVSVKEEESSGNISKDLK 1632
Query: 953 DAL-ESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEK 1011
D + E KE D A + S S G + A E
Sbjct: 1633 DKIVEKAKESLDTAAVVQVGISRNQSH---SSPSVSPSRSHSPSGSQTRSHSSSASSAES 1689
Query: 1012 KDG-PDKERKEKTKPERYKEKSSDKDKSEKSI-LEKCQKDKEFDKCFKEKKD-TKEKHKD 1068
+D K++KEK K +++K+ K + + LEK QK K K K+ KD KEK KD
Sbjct: 1690 QDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1749
Score = 55.5 bits (132), Expect = 7e-07
Identities = 97/394 (24%), Positives = 155/394 (39%), Gaps = 71/394 (18%)
Query: 286 KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKD 345
K TS + ST +S +D F P+ + E+ + KN ++ +P ++
Sbjct: 1414 KEARTSDKHDSTRASSNKD---FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRN 1470
Query: 346 EYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISI---------------PKMEVKS 390
+ + + P +++ L KK KSNS S P E KS
Sbjct: 1471 K----DSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1526
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKE 450
KN P K + + + + +++S G KL + + P E Q +
Sbjct: 1527 VDKN----PCKDREKHVLEARNNKESS-----GNKL---LYILNPPETQVEKEQITGQID 1574
Query: 451 KNKVKKKRKKETKGR-EVRFGKRSDKFCS----SESESESSESGEDDRDSLGSSGCLKGS 505
K+ VK K + R + +D+ +ES+SES+ S +++ S S LK
Sbjct: 1575 KSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDK 1634
Query: 506 PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSL 565
+V K SL ++ G S +N SH SSP+ S S
Sbjct: 1635 -IVEKAKE---SLDTAAVVQVGIS----RNQSH----------------SSPSVSPSRSH 1670
Query: 566 SDS-TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDK 624
S S ++TR +SS SS ES +K+++ K+ KK G +L+K
Sbjct: 1671 SPSGSQTR-----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1725
Query: 625 EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFT 658
K KHK K KNK+K + + K+KS T
Sbjct: 1726 SQK--HKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1757
Score = 34.7 bits (78), Expect = 1.3
Identities = 87/439 (19%), Positives = 165/439 (37%), Gaps = 40/439 (9%)
Query: 46 DGGKEVRERASKRKLPFTAGANGEQKDSD---TEKQGPERKRIKKEPVTRKAGLLFGMGL 102
D E+ + K + G+ KD D EK+ PE+++ +P K L +
Sbjct: 1345 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQP--EKESNLDRLNE 1402
Query: 103 SGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVN 162
G LS+ + A A+S D TP ++ + S+SK +D+ N
Sbjct: 1403 QGNFKS--LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTR--EYSSSKRRDEKN 1458
Query: 163 KRNERGET----RLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEA-CNRGYYDVA 217
+ R ++ + + + R ++L +G + K + + + ++ YD
Sbjct: 1459 ELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK 1518
Query: 218 KQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSP 277
+ + D + + +A NN KLL Y NP ++ + E +
Sbjct: 1519 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLL--YILNPPETQVEKEQITGQIDKS 1576
Query: 278 TMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQ 337
T + K + S S++ + E D +F P D N +DSE +K + +
Sbjct: 1577 T----VKPKPQLSHSSRLSSDLTRETDEAAFEP----DYNESDSESNVSVKEEESSGNIS 1628
Query: 338 KATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTI 397
K +KD+ + D V R ++ S+ +S + S ++
Sbjct: 1629 K---DLKDKIVEKAKESLDTAAVVQ-----VGISRNQSHSSPSVSPSRSHSPSGSQTR-- 1678
Query: 398 APKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQK-EKNKVKK 456
SH + +++ +D+ EK + H K + + +K +K+K KK
Sbjct: 1679 -----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKK 1733
Query: 457 KRKKETKGREVRFGKRSDK 475
K+ K+ K +E K K
Sbjct: 1734 KKSKKNKDKEKEKEKDDQK 1752
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 98.2 bits (243), Expect = 9e-20
Identities = 198/910 (21%), Positives = 342/910 (37%), Gaps = 122/910 (13%)
Query: 437 SKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSL 496
SK +E NA + NK KK RK+ KG E + +S E + E+ DSL
Sbjct: 916 SKEKESENAPGDGKGNKHKKHRKRR-KGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
Query: 497 GSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISS 556
+ V +P S++ S S ++ P TK R ++ +S
Sbjct: 975 FVLPSRDDATPVRDEPMDAESITFKSVSE--KDKRERDKPKAKGDKTK--RKNDGSAVSK 1030
Query: 557 PAWSEVSSLSDSTRTRLTSESDYSSEGSS-VESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
+ + + ++ E + S ++ K + ++ K +S S+K +
Sbjct: 1031 K--ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
Query: 616 EGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLE 675
A K KE + K K +EK + S+++K + T + E +K+ ++K L+
Sbjct: 1089 RKAHSKSAKEHQETKPVK-------EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD 1141
Query: 676 ND-LSTENKLKVLKHDRDHFKKEEKLSKMKLEE------KEWLFKDEKSLKRIKDTNKDI 728
N + K + D+D K+SK+++ E K + D + + R + +K I
Sbjct: 1142 NKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDK-I 1200
Query: 729 SRSFREEKDRSNK--------AEKERSLKEKSPKEEKL--RLYKEERKKKSKDRPSKLEK 778
S S +K + N+ E + KE S K E ++ +E+ K K + + + E
Sbjct: 1201 SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
Query: 779 KNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQF--------------- 823
+ D S K + K + +EY N N
Sbjct: 1261 SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK 1320
Query: 824 LENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKE 883
+ +D + D + + S + + K + S + Y + +S+ K I + K+
Sbjct: 1321 WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK-IQKFTKD 1379
Query: 884 DSKERRRDSRAREKRDYREPFFRKKDRDY--LDK-NSEKRKEQTEKHKSVP--------- 931
S E + K + KDRDY L+K N EKRK T+ K
Sbjct: 1380 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGN 1439
Query: 932 -GYLSEKDKKRRESAEAGRDRKDALESCKERRDGR----------AKPEEAHREELKECG 980
LS+ K+ R S + R + + RD + +K + E +
Sbjct: 1440 FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1499
Query: 981 CESGFKDKSDGDFGKGLEPWERHHPAR----EKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
S KD + G K E ER P + K+ P ++RK Y K +++
Sbjct: 1500 SPSRNKDSASGQKNKPRE--ERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1557
Query: 1037 KSEKSILEKCQKDKEFDKCFKEKKDTKEKH----------KDTHGKDKERKASLDQG--K 1084
KS+ + KD+E K E ++ KE +T + ++ +D+ K
Sbjct: 1558 T--KSVDKNPCKDRE--KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613
Query: 1085 EKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLP 1144
K + + +S D + + D+ A D +E D +S + K E+S
Sbjct: 1614 PKPQLSHSSRLSSDLTRETDE----------AAFEPDYNESDSESNVS--VKEEESSGNI 1661
Query: 1145 RTDGLQEK--EEGREAY---------ASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADA 1193
D L++K E+ +E+ S SS P R R +A +
Sbjct: 1662 SKD-LKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1720
Query: 1194 GRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
+ K +K KEKK + +K+K K A + +K K K +K KK +K K
Sbjct: 1721 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK----NKDK 1776
Query: 1254 SKHKEKSDKE 1263
K KEK D++
Sbjct: 1777 EKEKEKDDQK 1786
Score = 87.4 bits (215), Expect = 2e-16
Identities = 222/1159 (19%), Positives = 420/1159 (36%), Gaps = 138/1159 (11%)
Query: 555 SSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSS 614
S +++ S S STR+R S S S S P +R + R S +S
Sbjct: 696 SRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHR 755
Query: 615 AEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILL 674
+ P + + ++ + + + ++ Q + + Y + D
Sbjct: 756 SRSRSPPYRRYHS---RSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYY 812
Query: 675 ENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFRE 734
+ RD F+KE + + + + +EW K K +R
Sbjct: 813 GRSVDF----------RDPFEKE-RYREWERKYREWYEKYYKGYAAGAQPRPSANRE-NF 860
Query: 735 EKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN--DLKEDKISKEKE 792
+R S + +E+ + + + P KL ++ + K++ SKEKE
Sbjct: 861 SPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKE 920
Query: 793 KIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF 852
K K K +R+ +E FL E + S + + +DS F
Sbjct: 921 SENAPGDGKGNKHKKHRKRRKGEE---SEGFLNPELLETSRKSREPTGVEENKTDSLFVL 977
Query: 853 KGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDY 912
D T RD D+ + ++D +ER + +K + ++
Sbjct: 978 PSRDD----ATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKEN 1033
Query: 913 LDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAH 972
+ K ++ +E+ + + KK +E + K + S K+ + P +AH
Sbjct: 1034 IVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKI-TGTPRKAH 1092
Query: 973 REELKECGCESGFKD-KSDGDFGKGLEPWE---RHHPAREKEKKDGPDKERKEKTKPERY 1028
+ KE K+ K D+ K ++ + + A++ +K+ P + EK K +
Sbjct: 1093 SKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK-RKT 1151
Query: 1029 KEKSSDKDKSEKSI----------------------LEKCQKDKEFDKCFKEKKDTKEKH 1066
+EK DKD S+ EK + E DK K K
Sbjct: 1152 EEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKL 1211
Query: 1067 KDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDD 1126
GK ++ KE EK + S K++ KGK + + + D
Sbjct: 1212 NRETGKKIGSTENISNTKEPSEK----LESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1267
Query: 1127 RDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDK----QHPERQKDK--- 1179
S +G S+ +TD + + E Y +D + D Q P+ + DK
Sbjct: 1268 YTSTSSTGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF 1326
Query: 1180 --EPRDRRKDRGAADAGR--------DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDST 1229
E D + + + G+ K K+ EK+ + S + K KD S +
Sbjct: 1327 ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD-VSHEII 1385
Query: 1230 QDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS--DKEHSKERKSSRSADAEKSL------- 1280
Q + K+ K A+ +K K+K ++ S +KE+ ++RK+S + E +L
Sbjct: 1386 QHEV-------KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1438
Query: 1281 -LEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESAC 1339
+ L + + D +D S+ FT + + D + S+
Sbjct: 1439 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDK------------KTDYDTREYSSSK 1486
Query: 1340 LPEKLKEKERHRHSSSSSKKSHDRERAK-KEKAEKKEKGEDYKEGGSRKDSGQYEKDFLE 1398
++ E R + S S +K S ++ K +E+ + +KG G S+K + +D
Sbjct: 1487 RRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT----GDSKKSNSSPSRDRKP 1542
Query: 1399 ADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKE 1458
D + +Y+ K E+ K+++ + ++K+ E +K+ G+ + IL
Sbjct: 1543 HD-HKATYDTKRPNEET--KSVDKNPCKDREKHVLEARNNKESS------GNKLLYILNP 1593
Query: 1459 KKKR-EKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQ-KPATRDKDSPPRVLKD 1516
+ + EK + + +K + + +L R + +P + DS V
Sbjct: 1594 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
Query: 1517 KSRDEGPRLGDAK------LKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPRE 1570
+ G D K KE A + G S+ + V+PS+ ++ R
Sbjct: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRS 1713
Query: 1571 KLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMK---------QMEKLRH---RSGDP 1618
++ +K+ + ++HK+HK+ K + +K +H +S
Sbjct: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
Query: 1619 KLKEKAKPADDGRKKGLDI 1637
K KEK K DD + K + +
Sbjct: 1774 KDKEKEKEKDDQKVKSVTV 1792
Score = 82.8 bits (203), Expect = 4e-15
Identities = 167/840 (19%), Positives = 306/840 (36%), Gaps = 128/840 (15%)
Query: 286 KGTYTSSEESSTESSEEEDA--PSFAPSSSVDGNNTDSEFEKGLKHKAKNPEP------- 336
KG T + + S++E+ P+ P VDG S + KAK P
Sbjct: 1015 KGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS 1074
Query: 337 -------QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVK 389
+K T + + + Q+ P ++K +KKDY K+ KS + + K
Sbjct: 1075 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEK--VKKDYSKDVKSEKLTTKEEKAKK 1132
Query: 390 SYTKNNTIAPKKASHRILSD----TSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNA 445
KN + K + ++ D E +S+ + +L I+ S R+
Sbjct: 1133 PNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKIS-----KLEVTEIVKPSPKRKMEPD 1187
Query: 446 KQQKEKNKVKKKRKKETKGREVRFGKRS-DKFCSSESESESSESGE--DDRDSLGSSGCL 502
++ ++ K K ++++ + + K S+E+ S + E E + S +
Sbjct: 1188 TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKV 1247
Query: 503 KGS---PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAW 559
KG + + S + + +STSS G S +K + T + + ++
Sbjct: 1248 KGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA 1307
Query: 560 SEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAV 619
+V + +++ + D+ SE V+S +P +
Sbjct: 1308 EDVIIMIQVPQSK-WDKDDFESEEEDVKSTQP---------------------------I 1339
Query: 620 PKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLS 679
+ K V+K TK + K E + S+K D+S
Sbjct: 1340 SSVGKPASVIKNVSTKPSNIVKYP------------------EKESEPSEKIQKFTKDVS 1381
Query: 680 TENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRS 739
E +++H+ K K K +++++ ++++ ++ K++ + S DR
Sbjct: 1382 HE----IIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKES---NLDRL 1434
Query: 740 NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDK 799
N+ +SL + S + + R +KD +KK D + S K + K +
Sbjct: 1435 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1494
Query: 800 EKLKKEKVYREDSAFDEYCNKNQFLENE--------DTKFSLSDDQRDRWFSDLSDSSFD 851
+ K +DSA + KN+ E D+K S S RDR D +++D
Sbjct: 1495 TRRKDSPSRNKDSASGQ---KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYD 1550
Query: 852 FKGED------------SWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRD 899
K + + V + R+ K S KL+ +++ + + +
Sbjct: 1551 TKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS 1610
Query: 900 YREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKD-------KKRRESAEAGRDRK 952
+P K + + S +T++ P Y +E D K+ S +D K
Sbjct: 1611 TVKP---KPQLSHSSRLSSDLTRETDEAAFEPDY-NESDSESNVSVKEEESSGNISKDLK 1666
Query: 953 DAL-ESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEK 1011
D + E KE D A + S S G + A E
Sbjct: 1667 DKIVEKAKESLDTAAVVQVGISRNQSH---SSPSVSPSRSHSPSGSQTRSHSSSASSAES 1723
Query: 1012 KDG-PDKERKEKTKPERYKEKSSDKDKSEKSI-LEKCQKDKEFDKCFKEKKD-TKEKHKD 1068
+D K++KEK K +++K+ K + + LEK QK K K K+ KD KEK KD
Sbjct: 1724 QDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
Score = 57.8 bits (138), Expect = 1e-07
Identities = 132/660 (20%), Positives = 237/660 (35%), Gaps = 91/660 (13%)
Query: 1015 PDKERKEKTKPER-YKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKD 1073
P R+E + +R KE+ K K ++ + ++ E+ K KE++ + + K +
Sbjct: 634 PPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGS 693
Query: 1074 KERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGS 1133
++S K + S FS + + +S +S + R
Sbjct: 694 SYSRSSYTYSKSRSGSTRSRSYSRSFS--RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSH 751
Query: 1134 GFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKE----------PRD 1183
G+ S P + +A+ R + + + P+ + ++E P D
Sbjct: 752 GYHRSR-SRSPPYRRYHSRSRSPQAF---RGQSPNKRNVPQGETEREYFNRYREVPPPYD 807
Query: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKD------------------------ 1219
+ G + RD EK + E+K +E EKY
Sbjct: 808 MKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLP 867
Query: 1220 ------------RKDRASVDSTQDKKNKQKLPEK--AEKKHAAEDKAKSKHKEKSD---- 1261
R+D S + + PEK A H +D KSK KE +
Sbjct: 868 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
Query: 1262 ---KEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLT 1318
+H K RK + ++E L +L E + + RE + + E +DS T
Sbjct: 928 GKGNKHKKHRKRRKGEESEGFLNPELLETS-RKSREPTG--VEENKTDSLFVLPSRDDAT 984
Query: 1319 AFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRER-AKKEKAEKKEKG 1377
+ EP + + + +E+++ + +K+ +D +KKE K KG
Sbjct: 985 PVRD----EPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKG 1040
Query: 1378 EDYKEGGSRKDSGQYEKDFLEA-DAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSERE 1436
K G R+ S + E +A + + N K+ + D+ I + K+ E +
Sbjct: 1041 PQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQ 1100
Query: 1437 PSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHH 1496
+K + KE K + ++ EK ++ + K +EK + D + R
Sbjct: 1101 ETKPV-KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGE----------KRKR 1149
Query: 1497 RDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVA 1556
+ E+K +D +S + S+ E + K K + EK P K DK++
Sbjct: 1150 KTEEKGVDKDFESSSMKI---SKLEVTEIVKPSPKRKMEPDTEKMDRTPEK-----DKIS 1201
Query: 1557 PSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSG 1616
S P KK RE G S + S+K + K+ K + K K+ G
Sbjct: 1202 LSA-PAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG 1260
Score = 55.5 bits (132), Expect = 7e-07
Identities = 97/394 (24%), Positives = 155/394 (39%), Gaps = 71/394 (18%)
Query: 286 KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKD 345
K TS + ST +S +D F P+ + E+ + KN ++ +P ++
Sbjct: 1448 KEARTSDKHDSTRASSNKD---FTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRN 1504
Query: 346 EYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISI---------------PKMEVKS 390
+ + + P +++ L KK KSNS S P E KS
Sbjct: 1505 K----DSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS 1560
Query: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKE 450
KN P K + + + + +++S G KL + + P E Q +
Sbjct: 1561 VDKN----PCKDREKHVLEARNNKESS-----GNKL---LYILNPPETQVEKEQITGQID 1608
Query: 451 KNKVKKKRKKETKGR-EVRFGKRSDKFCS----SESESESSESGEDDRDSLGSSGCLKGS 505
K+ VK K + R + +D+ +ES+SES+ S +++ S S LK
Sbjct: 1609 KSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDK 1668
Query: 506 PLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSL 565
+V K SL ++ G S +N SH SSP+ S S
Sbjct: 1669 -IVEKAKE---SLDTAAVVQVGIS----RNQSH----------------SSPSVSPSRSH 1704
Query: 566 SDS-TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDK 624
S S ++TR +SS SS ES +K+++ K+ KK G +L+K
Sbjct: 1705 SPSGSQTR-----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
Query: 625 EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFT 658
K KHK K KNK+K + + K+KS T
Sbjct: 1760 SQK--HKHKKKKSKKNKDKEKEKEKDDQKVKSVT 1791
Score = 34.7 bits (78), Expect = 1.3
Identities = 87/439 (19%), Positives = 165/439 (37%), Gaps = 40/439 (9%)
Query: 46 DGGKEVRERASKRKLPFTAGANGEQKDSD---TEKQGPERKRIKKEPVTRKAGLLFGMGL 102
D E+ + K + G+ KD D EK+ PE+++ +P K L +
Sbjct: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQP--EKESNLDRLNE 1436
Query: 103 SGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVN 162
G LS+ + A A+S D TP ++ + S+SK +D+ N
Sbjct: 1437 QGNFKS--LSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTR--EYSSSKRRDEKN 1492
Query: 163 KRNERGET----RLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEA-CNRGYYDVA 217
+ R ++ + + + R ++L +G + K + + + ++ YD
Sbjct: 1493 ELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK 1552
Query: 218 KQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSP 277
+ + D + + +A NN KLL Y NP ++ + E +
Sbjct: 1553 RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLL--YILNPPETQVEKEQITGQIDKS 1610
Query: 278 TMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQ 337
T + K + S S++ + E D +F P D N +DSE +K + +
Sbjct: 1611 T----VKPKPQLSHSSRLSSDLTRETDEAAFEP----DYNESDSESNVSVKEEESSGNIS 1662
Query: 338 KATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTI 397
K +KD+ + D V R ++ S+ +S + S ++
Sbjct: 1663 K---DLKDKIVEKAKESLDTAAVVQ-----VGISRNQSHSSPSVSPSRSHSPSGSQTR-- 1712
Query: 398 APKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQK-EKNKVKK 456
SH + +++ +D+ EK + H K + + +K +K+K KK
Sbjct: 1713 -----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKK 1767
Query: 457 KRKKETKGREVRFGKRSDK 475
K+ K+ K +E K K
Sbjct: 1768 KKSKKNKDKEKEKEKDDQK 1786
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 97.1 bits (240), Expect = 2e-19
Identities = 173/871 (19%), Positives = 353/871 (40%), Gaps = 109/871 (12%)
Query: 662 EDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLE-EKEWLFKDEKSLKR 720
++ +++ A+ S + ++L + +++E+L + ++ EKE L + E L++
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603
Query: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKS-KD-------- 771
++ ++ R +E+++ ++ +K+K+ +E ++ K E K+ KD
Sbjct: 604 VRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEE 663
Query: 772 ---------RPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ 822
+ +LEK+ ++++ +++KI ++ K + E++ SA++E K+
Sbjct: 664 LDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAK-RLEEIPLIKSAYEEQRIKDM 722
Query: 823 FL--ENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILET 880
L + E+ + + +R++ + S + D + + R + K E
Sbjct: 723 DLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEER 782
Query: 881 VKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKR-KEQTEKHKSVPGYLSEKDK 939
+ E+ R + + + K + R ++R+K+ + + E+ KE+ E+ ++ E+ +
Sbjct: 783 LAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELR 842
Query: 940 KRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCES--------GFKDKSDG 991
+ +E + + + +E K +R+ + E REE + G S G +D S+G
Sbjct: 843 EYQERVK----KLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRD-SEG 897
Query: 992 DFGKGLE---PWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQK 1048
+ KG E W R P +E + +G D++R + ER + D+D+ E S+ +
Sbjct: 898 TWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDR-EPSLRPDDDR 956
Query: 1049 --DKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDD- 1105
+ D ++ +E G D +R + + ++ + ++ DD
Sbjct: 957 VPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDR 1016
Query: 1106 --KKGKEK---SWYIADIFTDE---SEDDRDSCMG------SGFKMGEASDLPRTDGLQE 1151
++G ++ SW AD +DDR G S ++ + PR GL +
Sbjct: 1017 PPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRR-GLDD 1075
Query: 1152 KEEGREAYASDR--HRKSSDKQHPERQKDKEPRDRR---KDRGAADAGRDKKEKVFEKHK 1206
R DR R D + P R D + RR DRG R+ + +
Sbjct: 1076 DRGPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRG---PWRNADDDRIPRRG 1132
Query: 1207 EKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSK 1266
+ D+ D DR S + D+ ++ + + KEK+ +E
Sbjct: 1133 AEDDRGPWRNMDD--DRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWG 1190
Query: 1267 ERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFT 1326
+ SR ++ + EK E + ++ RE+ NDK E D D +E F
Sbjct: 1191 PPRESRPSEEREWDREK-ERDRDNQDREE-NDKDPERERDRERDVDRED--------RFR 1240
Query: 1327 EPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSR 1386
P + R +E SS + DR+ ++E+ +++ D +E
Sbjct: 1241 RPRDEGGWRRGPA-------EESSSWRDSSRRDDRDRDDRRRERDDRR----DLRERRDL 1289
Query: 1387 KDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELK 1446
+D L ++ VS +AD ++KD ER+P +++
Sbjct: 1290 RDDRDRRGPPLRSEREEVSSWRRAD--------------DRKDDRVEERDPPRRV----P 1331
Query: 1447 PYGSSAINILKEKKKREKHREK--WRDEKER 1475
P S ++RE +EK WR EK+R
Sbjct: 1332 PPALSRDRERDRDREREGEKEKASWRAEKDR 1362
Score = 81.3 bits (199), Expect = 1e-14
Identities = 177/891 (19%), Positives = 360/891 (40%), Gaps = 146/891 (16%)
Query: 734 EEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKE-DKISKEKE 792
+EK+ ++ LK S KE + L + + ++ K+R L + + +E ++ E +
Sbjct: 544 QEKEEQHQLAVTAYLKN-SRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQ 602
Query: 793 KIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF 852
K+ K ++E+L++E RE + +++ ++ + + L ++ ++L +F
Sbjct: 603 KVRKAEEERLRQEAKEREK---ERILQEHEQIKKKTVRERLEQIKK----TELGAKAFK- 654
Query: 853 KGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKR-DYREPFFRKKDRD 911
D + D ++ D + +E ++++ KE + + +EK+ DY F R K +
Sbjct: 655 ------DIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDY---FERAKRLE 705
Query: 912 YLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDR----KDALESCKERRDG--- 964
+ +EQ K + +++++R + + R++ K+ + E RD
Sbjct: 706 EIPLIKSAYEEQRIKDMDL---WEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVM 762
Query: 965 --RAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEK 1022
+A + + E+LK+ F+++ + LE +R R++E++ +E++E+
Sbjct: 763 RLKAARQSVYEEKLKQ------FEERLAEERHNRLEERKRQ---RKEERRITYYREKEEE 813
Query: 1023 TKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQ 1082
+R E+ K++ E+ E+ ++++E +E ++ +K ++ K ++R+ +++
Sbjct: 814 E--QRRAEEQMLKEREERERAERAKREEEL----REYQERVKKLEEVERKKRQRELEIEE 867
Query: 1083 GKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASD 1142
+ ++E+ + + +KD + G DRDS ++ G +D
Sbjct: 868 RERRREEERR--LGDSSLSRKDSRWG-----------------DRDS--EGTWRKGPEAD 906
Query: 1143 LPRTDGLQEKE----EGREAYASDRHRKSSDKQHPERQKDKEPR--------DRRKDRGA 1190
G EKE EGR+ S R D++ P R D E R DR RG
Sbjct: 907 SEWRRGPPEKEWRRGEGRDEDRSHRR----DEERPRRLGDDEDREPSLRPDDDRVPRRGM 962
Query: 1191 AD---AGRDKKEKVFEKHKEKKDKESTEKYKD-RKDRASVDSTQ--------DKKNKQKL 1238
D R +E F + D+ S D R R D + D+ ++ L
Sbjct: 963 DDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGL 1022
Query: 1239 PEKAEKKHAAEDKAKSKHKEKSDKEHSK-----ERKSSRSADAEKSLLEKLEEEALHEYR 1293
E A++ + D+ + ER S R+AD ++ L+++ R
Sbjct: 1023 DEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDR-GPRR 1081
Query: 1294 EDSNDKISEVSSDSFTDRGQEPGLTAFL--EVSFTEPPGDDKPRESACLPEKLKEKERHR 1351
+D+ D DRG G+ + G + + +P + E +R
Sbjct: 1082 GMDDDRGPRRGMDD--DRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGP 1139
Query: 1352 HSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSR---KDSGQYEKDFLEADAYGVSYNM 1408
+ DR + + +G+D + G R K G EK+ +++G
Sbjct: 1140 WRNMDD----DRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRES 1195
Query: 1409 KADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREK 1468
+ E E D+ E +D+++ +RE + K +RE+ RE+
Sbjct: 1196 RPSEEREWDREKE------RDRDNQDREENDK------------------DPERERDRER 1231
Query: 1469 WRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKS--------RD 1520
D ++R R +G R E RD + RD+D R D+ RD
Sbjct: 1232 DVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRD 1291
Query: 1521 EGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREK 1571
+ R G L+ + ++ + + D K ++ P + P +R RE+
Sbjct: 1292 DRDRRG-PPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRER 1341
Score = 79.7 bits (195), Expect = 3e-14
Identities = 146/759 (19%), Positives = 297/759 (39%), Gaps = 92/759 (12%)
Query: 590 KPVRKRQEHRKRASLSEK--KSPFLSSAEGAVP---------KLDKEGKVVKKHKTKHKH 638
K VR+R E K+ L K K + E P +L+KE K +++ +
Sbjct: 634 KTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEK 693
Query: 639 KNKEKGQCSISQELKLKSFTYE---------YEDSKQKSDKAILLENDLSTE--NKLKVL 687
K + +E+ L YE +E +++ + LE + + E N++ +
Sbjct: 694 KIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRM 753
Query: 688 KHDRDHFKK----------EEKLSKM----------KLEEKEWLFKDEKSLKRIKDTNKD 727
DRD F EEKL + +LEE++ K+E+ + ++ ++
Sbjct: 754 LEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEE 813
Query: 728 ISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKI 787
R E+ K +ER E++ +EE+LR Y+E KK ++E+K +E +I
Sbjct: 814 EQRRAEEQM---LKEREERERAERAKREEELREYQERVKKL-----EEVERKKRQRELEI 865
Query: 788 SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLE--NEDTKFSLSDDQRDRWFSDL 845
+ + + +E++ +L + R+DS + + ++ + + D+++ +++ +
Sbjct: 866 EERERR--REEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEG 923
Query: 846 SDSSFDFKGEDSWDSPVTDYRDMK------SDSVAKLILETVKEDSKERRRDSRAREKRD 899
D + ++ + D D + D V + ++ + + D +R D
Sbjct: 924 RDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGAD 983
Query: 900 YREPFFRKKDRDYLDKNSEKRKEQTEKHKS---VPGYLSEKDKKRRESAEAGRDRKDALE 956
P +R D D + +H P ++D+ +A+ R + ++
Sbjct: 984 DDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMD 1043
Query: 957 SCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPD 1016
+ R G A E R + + G + D D G + P R + GP
Sbjct: 1044 DDRGPRRGGADDE---RSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPR 1100
Query: 1017 KERKEKTKPERYKE------KSSDKDKSEKSILEKCQ---KDKEFDKCFKEKKDTK-EKH 1066
+ + P R + +++D D+ + E + ++ + D+ + D + +
Sbjct: 1101 RGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRR 1160
Query: 1067 KDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDD 1126
D R G +KEKA E + ++ + +E+ W +++D
Sbjct: 1161 GDDSRPGPWRPLVKPGGWREKEKA----REESWGPPRESRPSEEREWDREKERDRDNQDR 1216
Query: 1127 RDSCMGSGFKMGEASDLPRTDGLQE-KEEG----REAYASDRHRKSSDKQHPERQKDKEP 1181
++ + D+ R D + ++EG A S R SS + +R +
Sbjct: 1217 EENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRE 1276
Query: 1182 RDRRKD-RGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPE 1240
RD R+D R D D+ + E+++ S + DRKD D +++ +++P
Sbjct: 1277 RDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKD----DRVEERDPPRRVPP 1332
Query: 1241 KAEKKHAAEDKAKSK--HKEKSDKEHSKERKSSRSADAE 1277
A + D+ + + KEK+ K+R+S R E
Sbjct: 1333 PALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNE 1371
Score = 56.6 bits (135), Expect = 3e-07
Identities = 101/492 (20%), Positives = 201/492 (40%), Gaps = 75/492 (15%)
Query: 1149 LQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEK 1208
LQEKEE + A + K+S K+H ++ + RK+R + + +KE++ ++ E
Sbjct: 543 LQEKEEQHQL-AVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAEL 601
Query: 1209 KDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKER 1268
+ E+ + R Q+ K ++K E+ ++H K + + + K+
Sbjct: 602 QKVRKAEEERLR---------QEAKEREK--ERILQEHEQIKKKTVRERLEQIKKTELGA 650
Query: 1269 KSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEP 1328
K+ + D E LE+L+ + + + + +K + + + QE + F
Sbjct: 651 KAFKDIDIED--LEELDPDFIMAKQVEQLEKEKKELQERL--KNQEKKIDYF-------- 698
Query: 1329 PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKD 1388
++ + +P E R + + ER + E +EK ++K SR
Sbjct: 699 ---ERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLE-REKALEHKNRMSRM- 753
Query: 1389 SGQYEKDFLEADAYGVSYN-MKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKP 1447
+ D + + + + +E K E E++ ER+ +K E+ +
Sbjct: 754 -------LEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITY 806
Query: 1448 YGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDK 1507
Y +E+++ E+ K R+E+ER + LR +++ + + E+K R+
Sbjct: 807 YREKE---EEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQREL 863
Query: 1508 DSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDAR 1567
+ R ++ R+E RLGD+ L K + GD + S G + P D +
Sbjct: 864 EIEER---ERRREEERRLGDSSLSRK-----DSRWGD--RDSEGTWRKGPEADSEWRRGP 913
Query: 1568 P-REKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEKAKP 1626
P +E G+G + + H+R +ER + R GD + +E +
Sbjct: 914 PEKEWRRGEG---------------RDEDRSHRRDEERPR-------RLGDDEDREPSLR 951
Query: 1627 ADDGR--KKGLD 1636
DD R ++G+D
Sbjct: 952 PDDDRVPRRGMD 963
Score = 45.4 bits (106), Expect = 7e-04
Identities = 56/250 (22%), Positives = 105/250 (42%), Gaps = 31/250 (12%)
Query: 827 EDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSK 886
ED + + DR D F +G+DS P +R + + E +E+S
Sbjct: 1134 EDDRGPWRNMDDDRLSRRADDDRFPRRGDDSRPGP---WRPLVKPGGWRE-KEKAREESW 1189
Query: 887 ERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAE 946
R+SR E+R++ R+K+RD +++ E+ + E+ + + +D+ RR E
Sbjct: 1190 GPPRESRPSEEREWD----REKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDE 1245
Query: 947 AGRDRKDALESCK----ERRDGRAKPEEAH-REELKECGCESGFKDKSDG------DFGK 995
G R A ES RRD R + + R++ ++ +D D +
Sbjct: 1246 GGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSERE 1305
Query: 996 GLEPWERHHPAREK--EKKDGP----------DKERKEKTKPERYKEKSSDKDKSEKSIL 1043
+ W R ++ E++D P D+ER + E KEK+S + + ++ L
Sbjct: 1306 EVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESL 1365
Query: 1044 EKCQKDKEFD 1053
+ + + + D
Sbjct: 1366 RRTKNETDED 1375
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 97.1 bits (240), Expect = 2e-19
Identities = 129/561 (22%), Positives = 213/561 (37%), Gaps = 69/561 (12%)
Query: 691 RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKE 750
+ H KK E + L KD K TN + + E+ R N+A+K + +
Sbjct: 107 KTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADK--TPLK 164
Query: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEKKN----DLKEDKISKEKEKIFKEDKEKLKKE- 805
S + E+ + K + + + SK KN D K+ K SK+ F K KK+
Sbjct: 165 SSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL 224
Query: 806 -KVYREDSAFDEYCNKNQFLENEDTKFSLSDDQR---DRWFSDLSDSSFDFKGEDSWDSP 861
+ + E C++N + SDD+ D W + S ++ ++
Sbjct: 225 KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNN-----SKNYSLK 279
Query: 862 VTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFR--KKDRDYLDKNSEK 919
T Y + AK + EDSK+ ++DS+ +K ++ + KKD + D S
Sbjct: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGD 339
Query: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKEC 979
K++ + K KDKK+ + + +D K ES + G AK LK+
Sbjct: 340 SKDERKDTK--------KDKKKLKKDDKKKDTKKYPEST-DTESGDAKDARNDSRNLKKA 390
Query: 980 GC-ESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKS 1038
+ KD F E +++ EKKD D + K K + E+S+D D
Sbjct: 391 SKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK-KSVKNDEESTDADSE 449
Query: 1039 EKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISED 1098
K +K +KD EKK K+ KD KD ++ A + + D
Sbjct: 450 PKGDSKKGKKD--------EKKGKKDSKKDDKKKDAKKNAESTE------------MESD 489
Query: 1099 FSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREA 1158
KKD K KEK DI D +D E++D + E +
Sbjct: 490 LELKKDKKHSKEKKGSKKDIKKDARKDT------------ESTD------AEFDESSKTG 531
Query: 1159 YASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYK 1218
+ + K SD + E K ++ D + K E + K + + T +
Sbjct: 532 FKTSTKIKGSDTE-SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKT-TFN 589
Query: 1219 DRKDRASVDSTQDKKNKQKLP 1239
++ ++AS + K LP
Sbjct: 590 EKGEKASTGRVPPSREKPPLP 610
Score = 78.6 bits (192), Expect = 8e-14
Identities = 129/585 (22%), Positives = 226/585 (38%), Gaps = 65/585 (11%)
Query: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEP--RDRRKDRGAADAGRDKKEKVFEKHKE 1207
+E+ R Y S H K ++ + + +K P +D +K G+ + K+ V EK K
Sbjct: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKR 154
Query: 1208 KKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE 1267
+ + + T ++S ++ Q KK+K E +++ K SK+ + DK+ SK
Sbjct: 155 QNEADKTPL------KSSHENEQSKKSKSSSETNPESQNS---KTVSKNCSQKDKKDSKN 205
Query: 1268 RKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDR------GQEPGLTAFL 1321
K + + + L K + + + SND ISE+ S++ + GQ +
Sbjct: 206 SKKTNT----EFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
Query: 1322 EVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKE--KAEKKEKGED 1379
+ ++ S + K+ + SS +S D + AKK+ K +K K +D
Sbjct: 262 DAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321
Query: 1380 YK------------EGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
K E G KD E+ + D + + K + ++ + S +
Sbjct: 322 KKKDVKKDTESTDAESGDSKD----ERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDA 377
Query: 1428 KDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRH 1487
KD + R K + + K + I + + + +E +DEK+ +D D
Sbjct: 378 KDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSV 437
Query: 1488 HRDELLRHHRDEQK-PATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPV 1546
DE E K + + K + KD +D+ + DAK K + E E +
Sbjct: 438 KNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKK--DAK---KNAESTEMESDLEL 492
Query: 1547 KMSNGNDKVAP-SKDPGKKDARPREKLLGDGDL---MMTSFERMLSQKDLEIEERHKRHK 1602
K + K SK KKDAR ++ D + T F+ K + E +K
Sbjct: 493 KKDKKHSKEKKGSKKDIKKDAR-KDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYK 551
Query: 1603 ERMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKEST-PIP 1661
K +K+ G +K K+G + +KK F +K K ST +P
Sbjct: 552 PGAK--KKIDESDG---TSANSKMEGLESKRGFRMSSKK-----TTFNEKGEKASTGRVP 601
Query: 1662 PAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTP 1706
P+ E PA + L P ++ + P +P P P
Sbjct: 602 PSREKPPLPA----CEPSLPSPKVRRLCWCKMPPPPPKPRYAPLP 642
Score = 78.6 bits (192), Expect = 8e-14
Identities = 97/467 (20%), Positives = 194/467 (41%), Gaps = 55/467 (11%)
Query: 1005 PAREKEKKDG------PDKER--KEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCF 1056
P ++ KK G P+ ++ +EKTK + +K+ K E E+ +K K +
Sbjct: 126 PLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN---EQSKKSKSSSETN 182
Query: 1057 KEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIA 1116
E +++K K+ KDK+ + +K + + KKD K+ K + I+
Sbjct: 183 PESQNSKTVSKNCSQKDKK-------DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
Query: 1117 DIFTDES----------EDDRDSCMGSGFKMGEASDLPRTDGLQ----EKEEGREAYASD 1162
+I ++ S + D +S + + + + L+ K++ ++
Sbjct: 236 EICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKS 295
Query: 1163 RHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKD 1222
+S D + ++ K ++ +KD D +D + E K +++ T +KD
Sbjct: 296 SDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDT-----KKD 350
Query: 1223 RASVDSTQDKKNKQKLP-----EKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAE 1277
+ + KK+ +K P E + K A D K K+D + +K + S D+E
Sbjct: 351 KKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
Query: 1278 KSLLEKLEEEALHEYREDS--NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPR 1335
L K ++ + ++DS ++K S + + TD EP + + D+K
Sbjct: 411 SELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEP------KGDSKKGKKDEKKG 464
Query: 1336 ESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKD 1395
+ + K+ + S+ + + ++ KK EKK +D K+ +RKD+ + +
Sbjct: 465 KKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK-DARKDTESTDAE 523
Query: 1396 FLEADAYGVSYNMK---ADIEDELDKTIELFSTEKKDKNDSEREPSK 1439
F E+ G + K +D E E + + + +K D++D SK
Sbjct: 524 FDESSKTGFKTSTKIKGSDTESE-ESLYKPGAKKKIDESDGTSANSK 569
Score = 69.7 bits (169), Expect = 4e-11
Identities = 107/472 (22%), Positives = 184/472 (38%), Gaps = 68/472 (14%)
Query: 400 KKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKV----- 454
KKA ++ S +E + K + ++ P SK K+Q E +K
Sbjct: 111 KKAEYK----KSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSS 166
Query: 455 ------KKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLV 508
KK + E + K K CS + + +S S + + + L + K +P
Sbjct: 167 HENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHT----KNNPK- 221
Query: 509 LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDS 568
L S TS+ S +N + D ++D+ ++I+ AW S ++S
Sbjct: 222 -------KDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDD-ESINFDAWLRNYSQNNS 273
Query: 569 ----------TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGA 618
T+ + SS+ S +S + ++ +K +KK
Sbjct: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDV------- 326
Query: 619 VPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDL 678
K D E + +K + K+ +K + + ++ K K E + +S A ND
Sbjct: 327 --KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARND- 383
Query: 679 STENKLKVLKHDRDHFKKEEKL-----SKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFR 733
+ N K K+D D K +K+ S+ +LE KE ++K K K NK ++
Sbjct: 384 -SRNLKKASKND-DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
Query: 734 EEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSK------DRPSKLEKKNDLKEDKI 787
E D ++ + + +K K+ K K+++KK +K + S LE K D K K
Sbjct: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501
Query: 788 SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRD 839
K +K K+D K D+ FDE +K F TK SD + +
Sbjct: 502 KKGSKKDIKKDARK----DTESTDAEFDE-SSKTGF--KTSTKIKGSDTESE 546
Score = 58.9 bits (141), Expect = 6e-08
Identities = 105/463 (22%), Positives = 180/463 (38%), Gaps = 54/463 (11%)
Query: 367 LKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKL 426
LKKD +K K S+ + P E K + T +A L + + E + +K
Sbjct: 127 LKKDSKK--KGGSYATNP--ESKQIVEEKTKRQNEADKTPLKSSHENEQS-------KKS 175
Query: 427 RLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESS 486
+ S+ T ++ S QK+K K +K T+ + + D + S
Sbjct: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL--------KRS 227
Query: 487 ESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHW 546
++ D + S L L+L S S++ + + S Q + +++ ++TK+
Sbjct: 228 KTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYS---QNNSKNYSLKYTKYT 284
Query: 547 RTDNWKTI--SSPAWSEVS--SLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRA 602
+ D K SS A SE S + DS + + + D + K V+K E
Sbjct: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKD--------DKKKDVKKDTESTDAE 336
Query: 603 SLSEKKSPFLSSAEGAVPKLDKEGKVVKKH-KTKHKHKNKEKGQCSISQELKLKSFTYEY 661
S K + + K D + K KK+ ++ K + S+ LK S
Sbjct: 337 SGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKAS----K 392
Query: 662 EDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRI 721
D K+K K I D +E + K + D KK+ K + K+ + DE+S
Sbjct: 393 NDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT-----DNKKSVKNDEESTDAD 447
Query: 722 KDTNKDISRSFREEKDR---SNKAEKERSLK---EKSPKEEKLRLYKEER----KKKSKD 771
+ D + ++EK S K +K++ K E + E L L K+++ KK SK
Sbjct: 448 SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKK 507
Query: 772 RPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAF 814
K +K+ D E K + K+K E+S +
Sbjct: 508 DIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLY 550
Score = 50.1 bits (118), Expect = 3e-05
Identities = 78/352 (22%), Positives = 133/352 (37%), Gaps = 46/352 (13%)
Query: 286 KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKD 345
K T + +++ + + DA S S D + +K +K K + +K T
Sbjct: 279 KYTKYTKKDTKKNAKKSSDAES---EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDA 335
Query: 346 EYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHR 405
E +D+ +D D K L K D +K+TK + + +N++ KKAS
Sbjct: 336 ESGDSKDERKDTKK--DKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASK- 392
Query: 406 ILSDTSDEEDASVTVGTGEKLRLSAHTILPG-------SKTREPSNAKQQKE-------- 450
+D ++ +T T + L + SKT + K +E
Sbjct: 393 --NDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEP 450
Query: 451 KNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLK 510
K KK +K E KG+ + K+ DK ++ +ES+E D L LK
Sbjct: 451 KGDSKKGKKDEKKGK--KDSKKDDKKKDAKKNAESTEMESD---------------LELK 493
Query: 511 DPSLFSSLSASSTSSHGSSAAQ--KQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDS 568
S S A + + + D+ +K + K S SE S
Sbjct: 494 KDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPG 553
Query: 569 TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVP 620
+ ++ ESD +S S +E L+ R + K+ + +EK ++ G VP
Sbjct: 554 AKKKI-DESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGE---KASTGRVP 601
>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 97.1 bits (240), Expect = 2e-19
Identities = 84/278 (30%), Positives = 122/278 (43%), Gaps = 41/278 (14%)
Query: 12 QEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQK 71
+EE ++ +++K T +K P +R K + + S+R LP T E
Sbjct: 1303 EEEDCQAASLLQKYTDNSEK--------PSGKRLCKTKHLIPQESRRGLPLTGEYYVENA 1354
Query: 72 DSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVA-----LLMQMTAE 126
D K R R + EP + Y LS +Q L + A
Sbjct: 1355 DG---KVTVRRFRKRPEP----------------SSDYDLSPAKQEPKPFDRLQQLLPAS 1395
Query: 127 ESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
+S P ++P+ +QS P + VNK GET L RAA G +
Sbjct: 1396 QSTQLPCSSSPQETTQSR------PMPPEARRLIVNKN--AGETLLQRAARLGYEEVVLY 1447
Query: 187 LISEG-ADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNG 245
+ DVN +D AG+ ALHEAC RG+ ++ + LL GA+VN D PLHDA N
Sbjct: 1448 CLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND 1507
Query: 246 HYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283
H ++V+LLL YG +P + G T +K+ +S M L
Sbjct: 1508 HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
Length = 1755
Score = 97.1 bits (240), Expect = 2e-19
Identities = 84/278 (30%), Positives = 122/278 (43%), Gaps = 41/278 (14%)
Query: 12 QEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQK 71
+EE ++ +++K T +K P +R K + + S+R LP T E
Sbjct: 1337 EEEDCQAASLLQKYTDNSEK--------PSGKRLCKTKHLIPQESRRGLPLTGEYYVENA 1388
Query: 72 DSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVA-----LLMQMTAE 126
D K R R + EP + Y LS +Q L + A
Sbjct: 1389 DG---KVTVRRFRKRPEP----------------SSDYDLSPAKQEPKPFDRLQQLLPAS 1429
Query: 127 ESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
+S P ++P+ +QS P + VNK GET L RAA G +
Sbjct: 1430 QSTQLPCSSSPQETTQSR------PMPPEARRLIVNKN--AGETLLQRAARLGYEEVVLY 1481
Query: 187 LISEG-ADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNG 245
+ DVN +D AG+ ALHEAC RG+ ++ + LL GA+VN D PLHDA N
Sbjct: 1482 CLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND 1541
Query: 246 HYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283
H ++V+LLL YG +P + G T +K+ +S M L
Sbjct: 1542 HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1579
>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
Length = 1703
Score = 97.1 bits (240), Expect = 2e-19
Identities = 84/278 (30%), Positives = 122/278 (43%), Gaps = 41/278 (14%)
Query: 12 QEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQK 71
+EE ++ +++K T +K P +R K + + S+R LP T E
Sbjct: 1285 EEEDCQAASLLQKYTDNSEK--------PSGKRLCKTKHLIPQESRRGLPLTGEYYVENA 1336
Query: 72 DSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVA-----LLMQMTAE 126
D K R R + EP + Y LS +Q L + A
Sbjct: 1337 DG---KVTVRRFRKRPEP----------------SSDYDLSPAKQEPKPFDRLQQLLPAS 1377
Query: 127 ESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
+S P ++P+ +QS P + VNK GET L RAA G +
Sbjct: 1378 QSTQLPCSSSPQETTQSR------PMPPEARRLIVNKN--AGETLLQRAARLGYEEVVLY 1429
Query: 187 LISEG-ADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNG 245
+ DVN +D AG+ ALHEAC RG+ ++ + LL GA+VN D PLHDA N
Sbjct: 1430 CLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND 1489
Query: 246 HYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283
H ++V+LLL YG +P + G T +K+ +S M L
Sbjct: 1490 HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1527
>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 97.1 bits (240), Expect = 2e-19
Identities = 84/278 (30%), Positives = 122/278 (43%), Gaps = 41/278 (14%)
Query: 12 QEELPLSSDMVEKQTGKKDKDKVSLTKTPKLERGDGGKEVRERASKRKLPFTAGANGEQK 71
+EE ++ +++K T +K P +R K + + S+R LP T E
Sbjct: 1303 EEEDCQAASLLQKYTDNSEK--------PSGKRLCKTKHLIPQESRRGLPLTGEYYVENA 1354
Query: 72 DSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVA-----LLMQMTAE 126
D K R R + EP + Y LS +Q L + A
Sbjct: 1355 DG---KVTVRRFRKRPEP----------------SSDYDLSPAKQEPKPFDRLQQLLPAS 1395
Query: 127 ESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
+S P ++P+ +QS P + VNK GET L RAA G +
Sbjct: 1396 QSTQLPCSSSPQETTQSR------PMPPEARRLIVNKN--AGETLLQRAARLGYEEVVLY 1447
Query: 187 LISEG-ADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNG 245
+ DVN +D AG+ ALHEAC RG+ ++ + LL GA+VN D PLHDA N
Sbjct: 1448 CLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND 1507
Query: 246 HYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283
H ++V+LLL YG +P + G T +K+ +S M L
Sbjct: 1508 HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 95.9 bits (237), Expect = 5e-19
Identities = 206/873 (23%), Positives = 297/873 (34%), Gaps = 154/873 (17%)
Query: 1606 KQMEKLRHRSGDPKLKEKAKPADDG-----RKKGLDIPAKKPPGLDPPFKDKKLKESTPI 1660
KQ L S PK K +A PA G KG A PP PP K +TP
Sbjct: 906 KQAPALSMTSSSPK-KARATPAPKGIPASPSPKG----APTPPAATPP--SPKGGPATPS 958
Query: 1661 P-----PAAENKLHPASGADSKDWLAGPHMKEVLPASPR--PDQSRPTGVPTPTSVLSCP 1713
P P A P G + P P SP+ P P G PTP +V
Sbjct: 959 PKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAV---- 1014
Query: 1714 SYEEVMHTPRTPSCSADDYADLVFDCADSQHSTPVP---TAPTSACSPSFFDRFSVASSG 1770
TP +P S +TP P + P +A PS + S A++
Sbjct: 1015 -------TPPSPK--------------GSPAATPFPKGASTPPAATPPS--PKGSPAATP 1051
Query: 1771 LSENASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSME 1830
L + A PA L + + ++ P + + P+ +PMPP+
Sbjct: 1052 LPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG--APMPPAAT 1109
Query: 1831 DRAPLPPV--PAEKFACLSPGYY--SPDYGLPSPKVDALHCPPAAVVT------VTPSPE 1880
+P + P K A +P SP GL +P PAA TP P+
Sbjct: 1110 PPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPK 1169
Query: 1881 GVFSSLQAKPSPSPRAELLVPSLEGA------LPPD----LDTSEDQQA--TAAIIPPEP 1928
G ++ A P PSP+ L PS +GA PP L T + A T A PP P
Sbjct: 1170 GAPTTPAATP-PSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP 1228
Query: 1929 S--YLEPLDEG-PFSAVITEE---------PVEWAHPSEQALASSLIGGTSENP------ 1970
P +G P + T P + A A SL GG + P
Sbjct: 1229 KGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN 1288
Query: 1971 ---VSWPVGSDLLLKSPQRFPESPKRFCPADPLHS-AAPGPFSASEAPYPAPPASPAPYA 2026
V+ P SP + +P P P S P P A P PP+
Sbjct: 1289 PAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT 1348
Query: 2027 LPVAEPGLE------DVKDGVDAVPAAISTSEAAP-YAPPSGLES-FFSNCKSLPEAP-- 2076
LP P + K+G PAA + + P PPS + K P +P
Sbjct: 1349 LPATTPSSKGGPTTPSSKEG-PTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV 1407
Query: 2077 LDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFA------GPEDD 2130
+ ++P+ A V + A P S+G V PV A A GP
Sbjct: 1408 IPLSPKKAPATPVTREGAATP--------SKGDLTPPAVTPVSLKKAPATSAPKGGPATP 1459
Query: 2131 LDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVINGGDVSTVVAEEPPAL 2190
G P LP T + P + + + + P P + + V+ P +
Sbjct: 1460 SSKGD---PTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEV 1516
Query: 2191 PPDQASTR-------------LPAELEPEPS--------GEPKLDVALEAAVEAETVPEE 2229
P +S R PA L P+ + PK A+ EA P
Sbjct: 1517 PATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSS 1576
Query: 2230 RARGDPD----SSVEPAPVPPEQ--RPLGSGDQGAEAEGPPAASLCAPD-GPAPNTVAQA 2282
+ P S+ + AP P E P + EA PPA + +P+ GPA
Sbjct: 1577 KEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGT 1636
Query: 2283 QAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQ 2342
+ P ++ + A G P+A++ P + P A ++E+
Sbjct: 1637 PTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTA--LKEVLVAPAPESTP 1694
Query: 2343 MLANQSKQGPPPSEKECAPTPAPVTRAKARGSE 2375
++ +++GP + P + GS+
Sbjct: 1695 IITAPTRKGPQTKKSSATSPPICPDPSAKNGSK 1727
Score = 87.8 bits (216), Expect = 1e-16
Identities = 179/752 (23%), Positives = 239/752 (31%), Gaps = 167/752 (22%)
Query: 1656 ESTPIPPAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSY 1715
E+ P+ P+ +N P + + P + + +P+ P P G + +
Sbjct: 706 ENCPVAPSPQNTCAPLATL-----VLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSAL 760
Query: 1716 EEVMHTPRT-------PSCSADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVAS 1768
V +P+ S +A L + ADS V +P + P+
Sbjct: 761 APVASSPKECPTEDSGASATASSKGTLTY-LADSPSPLGVSVSPQTKRPPT--------- 810
Query: 1769 SGLSENASQAPARPLSTNLYRSVS-VDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPP 1827
+ S P P+ NL VS V+ PE S Q S + ++ SP PP
Sbjct: 811 ----KKGSAGPDTPIG-NLSSPVSPVEASFLPENSLSF------QGSKDSPATTHSPTPP 859
Query: 1828 SMEDRAPLPPVPAEKFACLSP-GYYSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSL 1886
S + AP P LSP G P P+P V L P T P S
Sbjct: 860 SPKG-APTPSAVTP----LSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMT 914
Query: 1887 QAKP-----SPSPRAELLVPSLEGALPPDLDTSEDQQATAAIIPPEPSYLEPLDEGPFSA 1941
+ P +P+P+ PS +GA P T PP P GP
Sbjct: 915 SSSPKKARATPAPKGIPASPSPKGAPTPPAAT-----------PPSPK------GGP--- 954
Query: 1942 VITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLH 2001
T P +WA A S GG + SP+ P P P+
Sbjct: 955 -ATPSP-KWAPTPPAATPPSPKGGPAT-------------PSPKGAPTPPAATPPSPKGG 999
Query: 2002 SAAPGPFSASEAPYPAPPA--SPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPP 2059
A P P A P PPA P+P P A P P ST AA P
Sbjct: 1000 PATPSPKGA-----PTPPAVTPPSPKGSPAATP-----------FPKGASTPPAATPPSP 1043
Query: 2060 SGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRG--LSHLGQVEP 2117
G + K P P P P A ++ + +G + + P
Sbjct: 1044 KGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP 1103
Query: 2118 VPWADAFAGPEDDLDLGPFS-LPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVING 2176
+P A P+ L P P P T + G LA P P GAP
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG-------GLATPP--PKGAP----- 1149
Query: 2177 GDVSTVVAEEPP------ALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEER 2230
T A PP A PP + + PA P P G +A + A T P
Sbjct: 1150 ----TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG----GLATPSPKGAPTTP--- 1198
Query: 2231 ARGDPDSSVEPAPVPPEQRPLGSGDQGAEAEGPPA--ASLCAPDGP-APNTVAQAQAADG 2287
++ P+P P G A PP+ L P AP T A +
Sbjct: 1199 ------AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK 1252
Query: 2288 AGPEDDTEASRAAAPAEGPP---GGIQ--PEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQ 2342
GP PA PP GG+ P P P P +P
Sbjct: 1253 GGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP--------------- 1297
Query: 2343 MLANQSKQGPPPSEKECAPTPAPVTRAKARGS 2374
K GP S + APTP T +GS
Sbjct: 1298 ------KGGPATSPPKGAPTPPAATPPSPKGS 1323
Score = 87.8 bits (216), Expect = 1e-16
Identities = 172/769 (22%), Positives = 250/769 (32%), Gaps = 137/769 (17%)
Query: 1650 KDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSV 1709
KD +P PP+ + P++ V P SP+ P PTP SV
Sbjct: 847 KDSPATTHSPTPPSPKGAPTPSA---------------VTPLSPKGVTLPPKETPTP-SV 890
Query: 1710 LSCPSYEEVMHTP---RTPSCSADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSV 1766
++ P +E TP + P+ S + + P +P A +P S
Sbjct: 891 VNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSP 950
Query: 1767 ASSGLSENASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASS-YDSPM 1825
+ + AP P +T P + PA S +P
Sbjct: 951 KGGPATPSPKWAPTPPAAT-------------PPSP----------KGGPATPSPKGAPT 987
Query: 1826 PPSMEDRAPL--PPVPAEKFACLSPGYYSPD-YGLPS--PKVDALHCPPAAVV------- 1873
PP+ +P P P+ K A P P G P+ P PPAA
Sbjct: 988 PPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSP 1047
Query: 1874 TVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQATAAIIPPEPSYLEP 1933
TP P+G + A PSP+ PSL+GA P T + A P+ + + P
Sbjct: 1048 AATPLPKGA-PTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPP 1106
Query: 1934 LDEGPF-SAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPK 1992
P + P + A + A S GG + P P+ P +P
Sbjct: 1107 AATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP-------------PKGAPTTPA 1153
Query: 1993 RFCPADPLHSAAPGPFSASEAPYPAPP------ASPAPYALPVAEPGLEDVKDGVDAVPA 2046
P+ A P P A P PP A+P+P P G A P+
Sbjct: 1154 ATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS 1213
Query: 2047 ---AISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFL 2103
A +T A P +P GL + + K P P P P A +
Sbjct: 1214 PKGAPTTPAATPPSPKGGLAT--PSPKGAPTTPAATPPSPKGGPATPPPKGA-------- 1263
Query: 2104 DGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFS-LPELPLQTKDAADG--EAEPVEESL 2160
P P A + L P P + T + G P + +
Sbjct: 1264 -------------PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310
Query: 2161 APPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAA 2220
PP PP G P PP + + PA P P G P L ++
Sbjct: 1311 TPPAATPPSPKG--------------SPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSS 1356
Query: 2221 VEAETVPEERARGDPDSSVE-----PAPVPPEQR-----PLGSGDQGAEAEGPPAASLCA 2270
T P + P ++ PA PP + P GD + A P + A
Sbjct: 1357 KGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV-IPLSPKKA 1415
Query: 2271 PDGPAPNTVAQAQAADGAGPEDDTEASRAAAPA-EGPPGGIQPEAAEPKPT--AEAPKAP 2327
P P A + P T S APA P GG +++ PT A P +P
Sbjct: 1416 PATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSP 1475
Query: 2328 RVEEIPQRMTRNRA--QMLANQSKQGPP--PSEKECAPTPAPVTRAKAR 2372
+ P+++ + + + A + G P P+ +P P T + R
Sbjct: 1476 KEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRR 1524
Score = 68.9 bits (167), Expect = 6e-11
Identities = 170/758 (22%), Positives = 238/758 (31%), Gaps = 145/758 (19%)
Query: 1643 PGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEVLP-ASPRPDQSRPT 1701
P P F+ P+ P A LA + E LP P + P
Sbjct: 567 PKNSPSFQSTSSSPEIPLSPEAT--------------LAKKSLGEPLPIGKPASSMTSPL 612
Query: 1702 GVPTPTSVLSCPSYE--EVMHTPRTPSCSADDYADLVFDCADSQHSTPVPTAPTSACSPS 1759
GV + SV+ SY + S A + AD P APT+A S
Sbjct: 613 GVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESAD-----PAGVAPTTAKGTS 667
Query: 1760 FFDRFSVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAAS 1819
+ + AS L S AP + V +
Sbjct: 668 TYT--TTASPFLEGTVSLAP-------------------------------KNHPVKEGT 694
Query: 1820 SYDSPMPPSMEDRAPLPPVPAEKFACLSPGYYSPDY--GLPSPKVDALHCPPAAVVTVTP 1877
P+ P+ + P+ P P A L+ +P+ +PSP + PPA T
Sbjct: 695 LTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSL-----PPAGTPPGTK 749
Query: 1878 SPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQATAAIIPPEPSYLEPLDEG 1937
+G+ + P S E +ED A+A L L +
Sbjct: 750 KVDGISHTSALAPVASSPKEC--------------PTEDSGASATA--SSKGTLTYLADS 793
Query: 1938 PFSAVITEEPVEWAHPSEQALAS--SLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFC 1995
P ++ P P+++ A + IG S +PVS PV + L ++ F S
Sbjct: 794 PSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLS-SPVS-PVEASFLPENSLSFQGSKD--- 848
Query: 1996 PADPLHSAAPGPFSASEAPYPAP--PASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEA 2053
P + +P P S AP P+ P SP LP E V + P + A
Sbjct: 849 --SPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNL--PFPKEGPATPA 904
Query: 2054 APYAPPSGLESFFSNCKSLPEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLG 2113
AP + S AP + P+ A A P G
Sbjct: 905 PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKG-----------G 953
Query: 2114 QVEPVP-WADAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMPPGAPG 2172
P P WA P + P P + P + PP P G P
Sbjct: 954 PATPSPKWAPT----------PPAATPPSPKGGPATPSPKGAPTPPAATPPS--PKGGPA 1001
Query: 2173 VINGGDVSTVVAEEPP-------ALPPDQASTRLPAELEPEPSGEPKLDVALEAA--VEA 2223
+ T A PP A P + ++ PA P P G P + A A
Sbjct: 1002 TPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPA 1061
Query: 2224 ETVPEERARGDPDSSVEPAPVPPEQRPLG--SGDQGAEAEG---PPAASLCAPDG----- 2273
T+P + G S++ AP PP P G +G PPAA+ +P G
Sbjct: 1062 ATLPSPKG-GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATP 1120
Query: 2274 ---PAPNTVAQAQAADGAGPEDDTEASRAAAPAEGPP---GGIQPEAAEPKPTAEAPKAP 2327
AP T A + G PA PP GG+ + PT A P
Sbjct: 1121 PHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP 1180
Query: 2328 RVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTPAP 2365
P+ + A + PPS K TP+P
Sbjct: 1181 S----PKGGLATPSPKGAPTTPAATPPSPKGGLATPSP 1214
Score = 59.7 bits (143), Expect = 4e-08
Identities = 122/480 (25%), Positives = 171/480 (35%), Gaps = 82/480 (17%)
Query: 1616 GDPK------LKEKAKPADDGRKKGLDIPAK---KPPGLDPPFKDKKLKESTPIPPAAEN 1666
GDP L K PA ++G P+K PP + P K S P
Sbjct: 1400 GDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAP------- 1452
Query: 1667 KLHPASGADSKDWLAGPHMKEVLPASPR----PDQ----SRPTGVPTPTSVLSCPSYEEV 1718
K PA+ + D P + V P SP+ P Q S P P + + P+ V
Sbjct: 1453 KGGPATPSSKGD----PTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAV 1508
Query: 1719 M-----HTPRTPSCSADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVASSGLSE 1773
+ P TPS D A + TP AP A P S +
Sbjct: 1509 IPSSPKEVPATPSSRRDPIAPTATLLSKK---TPATLAPKEALIPPAMTVPSPKKTPAIP 1565
Query: 1774 NASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGD--KLFRQQSVPAASSYDSPMPPSMED 1831
+APA P S +V TP +L +V + S ++P PP++
Sbjct: 1566 TPKEAPATPSSKEASSPPAV----TPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTP 1621
Query: 1832 RAPL--PPVPAEKFACLSPGYYSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAK 1889
+P P PA K SP PS D+ P + + + L AK
Sbjct: 1622 PSPEKGPATPAPKGTPTSPPV------TPSSLKDSPTSPASVTCKMGATVPQASKGLPAK 1675
Query: 1890 PSPSPRAELLV-PSLEGALPPDLDTSEDQQ-----ATAAIIPPEPSYLEPLDEGPFSAVI 1943
P+ E+LV P+ E T + Q AT+ I P+PS +GP S V
Sbjct: 1676 KGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG-SKGPLSTVA 1734
Query: 1944 TEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSA 2003
P + + ++ S +P K P PES + PL +A
Sbjct: 1735 ---PAPLLPVQKDSSKTAKGKDASHSP-----------KGPLAPPESKA----STPLTAA 1776
Query: 2004 A-----PGPFSASEAPYPAPPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAP 2058
A P P SAS + P+PP S P A P P L + + + P + S + P AP
Sbjct: 1777 AFEKVLPKPESASVSAAPSPPVS-LPLA-PSPVPTLPPKQQFLPSSPGLVLESPSKPLAP 1834
Score = 46.2 bits (108), Expect = 4e-04
Identities = 87/326 (26%), Positives = 121/326 (37%), Gaps = 53/326 (16%)
Query: 1632 KKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLA--GP-HMKEV 1688
+KG PA K PP LK+S P + K+ SK A GP +KEV
Sbjct: 1625 EKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEV 1684
Query: 1689 LPASPRPDQSRPTGVPT----------PTSVLSCP-------SYEEVMHTPRTPSCSADD 1731
L A P P+ + PT TS CP S + P
Sbjct: 1685 LVA-PAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQK 1743
Query: 1732 YADLVFDCADSQHSTPVPTAP--TSACSPSFFDRF-SVASSGLSENASQAPARPLSTNLY 1788
+ D+ HS P AP + A +P F V S + S AP+ P+S L
Sbjct: 1744 DSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLA 1803
Query: 1789 RSVSVDIRRTPEEEFSVGDKLFRQQSVPAA-----SSYDSPMPPSMEDRAPLPPVPAEKF 1843
S + P +QQ +P++ S P+ P+ ED LP +P E
Sbjct: 1804 PS---PVPTLPP----------KQQFLPSSPGLVLESPSKPLAPADEDEL-LPLIPPEPI 1849
Query: 1844 ACLSPGYYSPDYGLPSPKVDALHCP-PAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPS 1902
+ P + S +P+PK + P P+A VT + +G + + S VP
Sbjct: 1850 SGGVP-FQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDES--------VPE 1900
Query: 1903 LEGALPPDLDTSEDQQATAAIIPPEP 1928
LE T + Q A AA I EP
Sbjct: 1901 LEEQDSTQATTQQAQLAAAAEIDEEP 1926
Score = 41.6 bits (96), Expect = 0.011
Identities = 94/364 (25%), Positives = 135/364 (37%), Gaps = 47/364 (12%)
Query: 1654 LKESTPIPPAAENKLHPASGA--DSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLS 1711
L + TP A + L P + K A P KE PA+P ++ TP++
Sbjct: 1534 LSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEA-PATPSSKEASSPPAVTPSTYKG 1592
Query: 1712 CPSYEEVMHTPRTPSCS---ADDYADLVFDCADSQHSTPVP---------------TAPT 1753
PS +E++ P S S A + + +TP P +PT
Sbjct: 1593 APSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652
Query: 1754 SACSPSFFDRFSV--ASSGLS--------ENASQAPARPLSTNLYRSVSVDIRRTPEEEF 1803
S S + +V AS GL + APA P ST + ++ R+ P+ +
Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPA-PESTPI---ITAPTRKGPQTKK 1708
Query: 1804 SVGDKLFRQQSVPAASSYD-SPMPPSMEDRAPLPPV--PAEKFACLSPGYYSPDYGLPSP 1860
S P S+ + S P S APL PV + K A +SP L P
Sbjct: 1709 SSATS---PPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPP 1765
Query: 1861 KVDA-LHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLDTSEDQQA 1919
+ A AA V P PE +S+ A PSP P + L PS LPP
Sbjct: 1766 ESKASTPLTAAAFEKVLPKPES--ASVSAAPSP-PVSLPLAPSPVPTLPPKQQFLPSSPG 1822
Query: 1920 TAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSLIGGTSENPVSWPVGSDL 1979
P +P L P DE +I EP+ P + L + ++ PV P
Sbjct: 1823 LVLESPSKP--LAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQP 1880
Query: 1980 LLKS 1983
+ K+
Sbjct: 1881 VTKN 1884
Score = 35.0 bits (79), Expect = 0.99
Identities = 84/370 (22%), Positives = 123/370 (33%), Gaps = 66/370 (17%)
Query: 2014 PYPAPPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLP 2073
P PP SPAP P++ + ++A+P+ PS + S
Sbjct: 43 PTLPPPCSPAPQQCPLS------------------AANQASPFPSPSTIAS--------- 75
Query: 2074 EAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPV-PWADAFAGPEDDLD 2132
PL+V P P + A P +FL G P+ P A A A P
Sbjct: 76 -TPLEV-PFPQSSSGTALPLGTAPEAPTFLPNLIG-------PPISPAALALASPMIAPT 126
Query: 2133 LGPFSLPELPLQTKDAADGEAEPVEESLAPPEEM-PPGAPGVINGGDVSTVVAEEPPALP 2191
L PL A + + S PP + P + V G V T+ A P+ P
Sbjct: 127 LKGTPSSSAPLALVALAPHSVQ--KSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEP 184
Query: 2192 PDQASTRLPAELEPEPSGEPKLDVALE-----------------AAVEAETVPEERARGD 2234
+ ++P+E+ P P G P + A++ T A
Sbjct: 185 KTNLN-KVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIAS 243
Query: 2235 P---DSSVEPAPVPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPE 2291
P D+++ + P Q P GS P A SL P T +Q A P+
Sbjct: 244 PQVKDTTISSVLISP-QNP-GSLSLKGPVSPPAALSLSTQSLPVV-TSSQKTAGPNTPPD 300
Query: 2292 DDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQG 2351
AP G + P+A + P V+ I + A + +S
Sbjct: 301 FPISLGSHLAPLHQSSFGSVQLLGQTGPSALSD--PTVKTISVDHSSTGASYPSQRSVIP 358
Query: 2352 PPPSEKECAP 2361
P PS E P
Sbjct: 359 PLPSRNEVVP 368
Score = 32.0 bits (71), Expect = 8.4
Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 5/116 (4%)
Query: 2192 PDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSSVEPAPVP-PEQRP 2250
P +A+ +PA + P +P+ + A+ A +V A G P ++ P P P+Q P
Sbjct: 2 PGEATETVPATEQELP--QPQAETAVLPMSSALSVTA--ALGQPGPTLPPPCSPAPQQCP 57
Query: 2251 LGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAEGP 2306
L + +Q + P + + P P + + G PE T P P
Sbjct: 58 LSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISP 113
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.127 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 122,043,687
Number of Sequences: 37866
Number of extensions: 7236958
Number of successful extensions: 98971
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 864
Number of HSP's successfully gapped in prelim test: 2519
Number of HSP's that attempted gapping in prelim test: 33106
Number of HSP's gapped (non-prelim): 34508
length of query: 2663
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2543
effective length of database: 13,703,598
effective search space: 34848249714
effective search space used: 34848249714
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.