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Search of human proteins with 134142335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134142335 ATP-binding cassette, sub-family C, member 1
isoform 5 [Homo sapiens]
(1466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 2909 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 2841 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 2640 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 2538 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1571 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 1416 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 1235 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 1177 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 1046 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 733 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 682 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 672 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 672 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 670 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 622 e-178
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 620 e-177
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 589 e-168
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 550 e-156
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 550 e-156
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 550 e-156
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 537 e-152
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 447 e-125
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 259 1e-68
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 155 2e-37
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 155 4e-37
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 136 1e-31
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 132 3e-30
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 129 2e-29
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 124 7e-28
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 119 2e-26
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 2909 bits (7541), Expect = 0.0
Identities = 1466/1466 (100%), Positives = 1466/1466 (100%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
Query: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
Query: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
Query: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
Sbjct: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
Query: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
Sbjct: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
Query: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
Query: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
Sbjct: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
Query: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
Sbjct: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
Query: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEI 1440
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEI
Sbjct: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEI 1440
Query: 1441 QEYGAPSDLLQQRGLFYSMAKDAGLV 1466
QEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1441 QEYGAPSDLLQQRGLFYSMAKDAGLV 1466
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 2841 bits (7365), Expect = 0.0
Identities = 1431/1432 (99%), Positives = 1431/1432 (99%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
Query: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
Query: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
Query: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
Sbjct: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
Query: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
Sbjct: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
Query: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
Query: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
Sbjct: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
Query: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
Sbjct: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
Query: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1432
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 1156 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1209
Query: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 1210 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1269
Query: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 1270 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
Query: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1449
Query: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 1450 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1506
Query: 848 EMGSYQELLARDGAF 862
E G+ +LL + G F
Sbjct: 1507 EYGAPSDLLQQRGLF 1521
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1496 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1531
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 2640 bits (6844), Expect = 0.0
Identities = 1352/1434 (94%), Positives = 1358/1434 (94%), Gaps = 63/1434 (4%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGAL VA+ G V
Sbjct: 661 LNGITFSIPEGAL----------------------------VAVVGQV------------ 680
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE--IGEKGVNLSGGQKQRVSL 778
GC S++ A +L D+ E + KGVNLSGGQKQRVSL
Sbjct: 681 --------GCGKS-----SLLSA--------LLAEMDKVEGHVAIKGVNLSGGQKQRVSL 719
Query: 779 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 838
ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI
Sbjct: 720 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 779
Query: 839 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 898
IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN
Sbjct: 780 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 839
Query: 899 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 958
GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV
Sbjct: 840 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 899
Query: 959 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 1018
KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV
Sbjct: 900 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 959
Query: 1019 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1078
YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK
Sbjct: 960 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1019
Query: 1079 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1138
ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR
Sbjct: 1020 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1079
Query: 1139 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1198
QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW
Sbjct: 1080 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1139
Query: 1199 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI
Sbjct: 1140 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1199
Query: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN
Sbjct: 1200 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1259
Query: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV
Sbjct: 1260 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1319
Query: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1320 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1373
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 1097 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1150
Query: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 1151 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1210
Query: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 1211 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1270
Query: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 1271 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1330
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 1331 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1390
Query: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 1391 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1447
Query: 848 EMGSYQELLARDGAF 862
E G+ +LL + G F
Sbjct: 1448 EYGAPSDLLQQRGLF 1462
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1437 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 2538 bits (6579), Expect = 0.0
Identities = 1302/1432 (90%), Positives = 1319/1432 (92%), Gaps = 56/1432 (3%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK R
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK--------------TR 766
Query: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
+ +++ Y L VD + ++ +S + ++
Sbjct: 767 ILVTHSMSY-----LPQVDVII--------------------VMSGGKISEMGSYQELLA 801
Query: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
G + +Y A + + +E ENG+ GK
Sbjct: 802 RDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--------- 852
Query: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
Sbjct: 853 --------QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 904
Query: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
Sbjct: 905 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 964
Query: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
Sbjct: 965 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1024
Query: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
Sbjct: 1025 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1084
Query: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
Sbjct: 1085 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1144
Query: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
Sbjct: 1145 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1204
Query: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
Sbjct: 1205 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1264
Query: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
Sbjct: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
Query: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1325 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1376
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 1100 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1153
Query: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 1154 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1213
Query: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 1214 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1273
Query: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 1274 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1333
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 1334 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1393
Query: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 1394 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1450
Query: 848 EMGSYQELLARDGAF 862
E G+ +LL + G F
Sbjct: 1451 EYGAPSDLLQQRGLF 1465
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1440 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
Score = 61.2 bits (147), Expect = 7e-09
Identities = 78/322 (24%), Positives = 128/322 (39%), Gaps = 42/322 (13%)
Query: 1156 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1209
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
Query: 1210 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1269
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
Query: 1270 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
Query: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
Query: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLR---------------VIV 1434
Q + + ++ L + LP + E GE R +IV
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILP---SGDRTEIGEKTRILVTHSMSYLPQVDVIIV 784
Query: 1435 LDKGEIQEYGAPSDLLQQRGLF 1456
+ G+I E G+ +LL + G F
Sbjct: 785 MSGGKISEMGSYQELLARDGAF 806
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1571 bits (4068), Expect = 0.0
Identities = 796/1440 (55%), Positives = 1040/1440 (72%), Gaps = 33/1440 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
Query: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
Query: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENIL 727
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +KGSVAYVPQQAWIQN +L+EN+L
Sbjct: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
FG L Y+ ++ACALL DLE+LP GD+TEIGEKG+NLSGGQ+QRVSLARAVYS+AD
Sbjct: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
Query: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
I+L DDPLSAVD+HV KHIF++VIGP+G+L KTR+LVTH +S+LPQ D IIV++ G++S
Sbjct: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
Query: 848 EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML------ 901
EMG Y LL R+G+FA FL YA E + E++ KEA +E+ +
Sbjct: 831 EMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLT 890
Query: 902 ----VTDSAGKQLQRQLSSSSS----YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADK 952
VT KQ RQLS+ SS + R H +E +Q EAK + L + +K
Sbjct: 891 DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEK 948
Query: 953 AQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHT 1012
A G V+LSV+WDY KA+GL + L++ +A+ +N WLS WT+D + + Q +T
Sbjct: 949 AAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNT 1008
Query: 1013 KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNL 1072
+RL VY ALGI QG V +MA++ GGI A+R LH LLH+ +RSP SFF+ TPSG +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 1073 VNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRF 1132
+N FSK++ VD ++ VI M + S FN I +VI+ +TP+ ++I PL ++Y VQRF
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRF 1128
Query: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1192
Y A+SRQLKRLESVSRSP+YSHF+ET+ G SVIRA+ F SD KVD NQ++ YP
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 1193 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSS 1252
I++NRWL++ +E VGNC+VLFAALFAVI R SL+ GLVGLSVSYSLQVT LNW++RM S
Sbjct: 1189 IISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
Query: 1253 EMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRH 1312
++E+NIVAVER+KEYS+TE EAPW ++ + PP WP G VEFRNY +RYR LD VLR
Sbjct: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRD 1308
Query: 1313 INVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITI 1372
+++ ++GGEKVGIVGRTGAGKSS+TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TI
Sbjct: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
Query: 1373 IPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
IPQDP+LFSG+LRMNLDPF YS+E++W +LEL+HL FVS+ P LD +C+EGGENL V
Sbjct: 1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
Score = 84.3 bits (207), Expect = 8e-16
Identities = 104/462 (22%), Positives = 190/462 (41%), Gaps = 30/462 (6%)
Query: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
+ + +LS F C AL FAV N L + SL + F
Sbjct: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
Query: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
Query: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
L ++ + G V +VG+ G GKSS+ L ++ +G + I G
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
Query: 707 -----SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 760
+ +PQ + + +LR N+ FG EE + + ++ L + P+G +
Sbjct: 1360 HDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWA-LELSHLHTFVSSQPAGLDFQ 1418
Query: 761 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 820
E G NLS GQ+Q V LARA+ + I + D+ +A+D I + +
Sbjct: 1419 CSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATI---RTQFDTC 1475
Query: 821 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
T + + H ++ + ++V+ G ++E S L+A G F
Sbjct: 1476 TVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
Score = 48.5 bits (114), Expect = 5e-05
Identities = 20/35 (57%), Positives = 29/35 (82%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1465
RV+VLDKG + E+ +P++L+ RG+FY MA+DAGL
Sbjct: 1492 RVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 1416 bits (3665), Expect = 0.0
Identities = 709/719 (98%), Positives = 712/719 (99%), Gaps = 6/719 (0%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK------GSVAYVPQ 713
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK S++Y+PQ
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
Score = 1205 bits (3118), Expect = 0.0
Identities = 632/713 (88%), Positives = 648/713 (90%), Gaps = 19/713 (2%)
Query: 739 SVIQACALLPDLEILPSGDRTEIG--EKGVNLSGGQKQRVSLARAVYSNA-------DIY 789
S++QA L L I S + E E+ GG +++ A ++ A +
Sbjct: 605 SIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGI 664
Query: 790 LFDDPLSAVDAHVGK----------HIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
F P A+ A VG+ + + +G + KTRILVTHSMSYLPQVDVII
Sbjct: 665 TFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVII 724
Query: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG
Sbjct: 725 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 784
Query: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 785 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 844
Query: 960 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 1019
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 845 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 904
Query: 1020 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 905 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 964
Query: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1139
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1024
Query: 1140 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1199
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1025 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1084
Query: 1200 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1259
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1085 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1144
Query: 1260 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1319
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1145 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1204
Query: 1320 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1379
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1205 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1264
Query: 1380 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1265 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1317
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 1041 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1094
Query: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 1095 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1154
Query: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 1155 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1214
Query: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 1215 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1274
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 1275 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
Query: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 1335 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1391
Query: 848 EMGSYQELLARDGAF 862
E G+ +LL + G F
Sbjct: 1392 EYGAPSDLLQQRGLF 1406
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1381 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 1235 bits (3196), Expect = 0.0
Identities = 666/1447 (46%), Positives = 939/1447 (64%), Gaps = 54/1447 (3%)
Query: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
Query: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
Query: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
Query: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
Query: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
Query: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
Query: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
Query: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
Query: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
Query: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
Query: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
Query: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSL 722
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IKG+ AYVPQQ+WIQN ++
Sbjct: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
Query: 723 RENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAV 782
++NILFG + E Y+ V++ACALLPDLE+LP GD EIGEKG+NLSGGQKQR+SLARA
Sbjct: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
Query: 783 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 842
Y N DIYL DDPLSAVDAHVGKHIF V+GP G+LK KTR+LVTHSM +LPQVD I+V+
Sbjct: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Query: 843 GGKISEMGSYQELLARDGAFAEFLRTY--------ASTEQEQDAEENGVTGVSGPGKEAK 894
G I E GSY LLA+ G FA+ L+T+ +T + EE+ G+ +E
Sbjct: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
Query: 895 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 949
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
Query: 950 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWT-DDPIVNGT 1008
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
Query: 1009 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1065
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
Query: 1066 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1125
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
Query: 1126 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1185
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Query: 1186 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1245
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
Query: 1246 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
Query: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
Query: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
Query: 1426 GGENLRV 1432
G NL +
Sbjct: 1433 AGGNLSI 1439
Score = 91.7 bits (226), Expect = 5e-18
Identities = 106/466 (22%), Positives = 191/466 (40%), Gaps = 31/466 (6%)
Query: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIW-SAPLQVILALYLLWLNLGPSVLAGVAVMVL 475
++ G IVN + D D W + L +I L ++ + + + + ++
Sbjct: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
Query: 476 MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
V V ++ + ++ +E ++G+ V++ AF+ + ++ E
Sbjct: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIR------AFEHQQRFLKHNE 1187
Query: 536 LKV-LKKSAYLSAVGTFTWVCTPF-LVALCTF---AVYVTIDENNILDAQTAFVSLALFN 590
+++ + S + + W+ LV T A+ + I + + FV N
Sbjct: 1188 VRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALN 1247
Query: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
I + LN L + S I V+++R+ + E P ++RP D I N
Sbjct: 1248 ITQ-TLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQ 1306
Query: 651 FTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---- 706
+ L GIT I + VVG+ G GKSSL + L ++ G + I G
Sbjct: 1307 VRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIA 1366
Query: 707 ---------SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSG 756
+ +PQ + + SLR N+ F +E +++ ++ L + L G
Sbjct: 1367 SIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA-LELAHLKSFVASLQLG 1425
Query: 757 DRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGM 816
E+ E G NLS GQ+Q + L RA+ + I + D+ +AVD I + +
Sbjct: 1426 LSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI---QNE 1482
Query: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
+ T I + H + + D ++V+ GKI E GS +ELL G F
Sbjct: 1483 FAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPF 1528
Score = 42.4 bits (98), Expect = 0.003
Identities = 20/35 (57%), Positives = 27/35 (77%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1465
+V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 1177 bits (3046), Expect = 0.0
Identities = 627/1422 (44%), Positives = 892/1422 (62%), Gaps = 42/1422 (2%)
Query: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
Query: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
Query: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
Query: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEP 735
VVG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 736 YYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPL 795
+ V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL
Sbjct: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
Query: 796 SAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 855
+A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQEL
Sbjct: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
Query: 856 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQ 913
L R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 841 LQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRE 888
Query: 914 LSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 970
S S + +T+E Q + W + D Q G+VK +V+ Y++A+
Sbjct: 889 RSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAV 942
Query: 971 GLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV 1030
G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +
Sbjct: 943 GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGL 1002
Query: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 1003 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 1062
Query: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1063 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 1122
Query: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +
Sbjct: 1123 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 1182
Query: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1183 VFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT 1242
Query: 1271 EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG 1330
KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGRTG
Sbjct: 1243 PKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTG 1302
Query: 1331 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1390
AGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1303 AGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL 1362
Query: 1391 FSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
++SDE +W +LE LK V++LP +L ++CA+ GE+L V
Sbjct: 1363 LQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
Score = 83.2 bits (204), Expect = 2e-15
Identities = 67/249 (26%), Positives = 113/249 (45%), Gaps = 19/249 (7%)
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
P + P GG I R+ + P + G++F I G V +VG+ G GKSS
Sbjct: 1251 PTCAAQPPWPQGG---QIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSS 1307
Query: 687 LLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQLE 733
L S LL + EG + I G ++ +PQ + SLR N+ +
Sbjct: 1308 LASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHS 1367
Query: 734 EPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDD 793
+ + ++ L + LP + + ++G +LS GQKQ + LARA+ I + D+
Sbjct: 1368 DEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDE 1427
Query: 794 PLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQ 853
+AVD + + ++G T +L+ H + + ++VM G+++E GS
Sbjct: 1428 ATAAVDPGTELQM-QAMLG--SWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPA 1484
Query: 854 ELLARDGAF 862
+LLA+ G F
Sbjct: 1485 QLLAQKGLF 1493
Score = 49.3 bits (116), Expect = 3e-05
Identities = 20/36 (55%), Positives = 31/36 (86%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1468 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 1046 bits (2704), Expect = 0.0
Identities = 555/1241 (44%), Positives = 795/1241 (64%), Gaps = 33/1241 (2%)
Query: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
Query: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
Query: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
Query: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
Query: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Query: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
Query: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
Query: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
Query: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPY 736
VG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P+
Sbjct: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
Query: 737 YRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLS 796
V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL+
Sbjct: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
Query: 797 AVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 856
A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQELL
Sbjct: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
Query: 857 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQL 914
R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 651 QRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRER 698
Query: 915 SSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG 971
S S + +T+E Q + W + D Q G+VK +V+ Y++A+G
Sbjct: 699 SIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVG 752
Query: 972 LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF 1031
+ ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +F
Sbjct: 753 TPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLF 812
Query: 1032 GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVI 1091
AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+ +
Sbjct: 813 ASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKL 872
Query: 1092 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV 1151
+ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S V
Sbjct: 873 RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSV 932
Query: 1152 YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIV 1211
SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V
Sbjct: 933 CSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
Query: 1212 LFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1271
AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 993 FAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP 1052
Query: 1272 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1331
KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRTGA
Sbjct: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
Query: 1332 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1391
GKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
Query: 1392 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
++SDE +W +LE LK V++LP +L ++CA+ GE+L V
Sbjct: 1173 QEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
Score = 82.8 bits (203), Expect = 2e-15
Identities = 61/218 (27%), Positives = 104/218 (47%), Gaps = 16/218 (7%)
Query: 658 PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----------- 706
P + G++F I G V +VG+ G GKSSL S LL + EG + I G
Sbjct: 1088 PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTL 1147
Query: 707 --SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK 764
++ +PQ + SLR N+ + + + ++ L + LP + + ++
Sbjct: 1148 RSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADR 1207
Query: 765 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 824
G +LS GQKQ + LARA+ I + D+ +AVD + + ++G T +L
Sbjct: 1208 GEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLG--SWFAQCTVLL 1264
Query: 825 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
+ H + + ++VM G+++E GS +LLA+ G F
Sbjct: 1265 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1302
Score = 49.3 bits (116), Expect = 3e-05
Identities = 20/36 (55%), Positives = 31/36 (86%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1277 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 733 bits (1892), Expect = 0.0
Identities = 445/1258 (35%), Positives = 698/1258 (55%), Gaps = 102/1258 (8%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
Query: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
G+Y E L F L+ +D EE+ V G + N
Sbjct: 614 KGTYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN---------- 651
Query: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
R S SS +S SR L+ + + L E ++++ G+V Y +Y +
Sbjct: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFR 706
Query: 969 AIGLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
A +I F IFL + N + +A ++WLS W + + VNG T+ +L +
Sbjct: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
Query: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
Query: 1075 RFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1134
RFSK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++
Sbjct: 824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFL 883
Query: 1135 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV 1194
+SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ +
Sbjct: 884 ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943
Query: 1195 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEM 1254
+RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+
Sbjct: 944 TSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003
Query: 1255 ETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1314
E +++VER+ EY++ EKEAPW+ Q+ PP +WP G + F N Y VL+H+
Sbjct: 1004 ENMMISVERVIEYTDLEKEAPWEYQK-RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
Query: 1315 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP 1374
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIP
Sbjct: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIP 1121
Query: 1375 QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Q+PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N V
Sbjct: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSV 1179
Score = 82.8 bits (203), Expect = 2e-15
Identities = 69/278 (24%), Positives = 126/278 (45%), Gaps = 20/278 (7%)
Query: 611 VSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPE 670
+S++R+ + E+ P ++RP I N F ++ P L +T I
Sbjct: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
Query: 671 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI-------------KGSVAYVPQQAWI 717
V +VG+ G GKSSL+SAL + + EG + I + ++ +PQ+ +
Sbjct: 1068 QEKVGIVGRTGAGKSSLISALF-RLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126
Query: 718 QNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRV 776
++R+N+ F +E + + +Q L +E LP TE+ E G N S GQ+Q V
Sbjct: 1127 FTGTMRKNLDPFNEHTDEELWNA-LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLV 1185
Query: 777 SLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVD 836
LARA+ I + D+ + VD + I + + + + T + + H ++ + D
Sbjct: 1186 CLARAILRKNQILIIDEATANVDPRTDELIQKKI---REKFAHCTVLTIAHRLNTIIDSD 1242
Query: 837 VIIVMSGGKISEMGS-YQELLARDGAFAEFLRTYASTE 873
I+V+ G++ E Y L ++ F + ++ E
Sbjct: 1243 KIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAE 1280
Score = 32.3 bits (72), Expect = 3.4
Identities = 15/35 (42%), Positives = 22/35 (62%), Gaps = 1/35 (2%)
Query: 1431 RVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1464
+++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1243 KIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 682 bits (1761), Expect = 0.0
Identities = 423/1267 (33%), Positives = 672/1267 (53%), Gaps = 120/1267 (9%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------SVAYVPQQA 715
L +VGQVGCGKSSLL A+L EM +EG V SVAY Q+
Sbjct: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKP 723
Query: 716 WIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQR 775
W+ N ++ ENI FG + Y++V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR
Sbjct: 724 WLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 783
Query: 776 VSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK-----NKTRILVTHSMS 830
+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK +T +LVTH +
Sbjct: 784 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQ 838
Query: 831 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPG 890
YL D II M G + G+ +++ +D E +T + Q+Q+ E++
Sbjct: 839 YLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELEKD--------- 888
Query: 891 KEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEA 950
EA Q L+R+ + YS + E ++ E +++ M
Sbjct: 889 MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MST 933
Query: 951 DKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT-- 1008
++ W Y+ + G F+ L IF + H +A +YWL+ WT + +N T
Sbjct: 934 VMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGK 993
Query: 1009 --QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFER 1066
Q + S+ GI + S+ V G+ A++ LH +LL+ I+ P+ FF+
Sbjct: 994 ADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT 1050
Query: 1067 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIY 1126
TP G ++NRFS + + +D IP ++ S + A +I ATP+ + + PLG+ +
Sbjct: 1051 TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAF 1110
Query: 1127 FFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1186
+F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF + D N
Sbjct: 1111 YFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNN 1170
Query: 1187 KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNW 1246
AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL + Y+L +T YLNW
Sbjct: 1171 IAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLLYALTITNYLNW 1228
Query: 1247 LVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
+VR +++E + AV+++ + E E + + P WPQ G ++ + C+RY +
Sbjct: 1229 VVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1288
Query: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH
Sbjct: 1289 LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1348
Query: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +LP LD E
Sbjct: 1349 LRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTE 1408
Query: 1426 GGENLRV 1432
GGEN V
Sbjct: 1409 GGENFSV 1415
Score = 85.1 bits (209), Expect = 4e-16
Identities = 139/651 (21%), Positives = 259/651 (39%), Gaps = 88/651 (13%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
+ + P L + I G V + G+ G GKSSL A +D +G + I G
Sbjct: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISK 1343
Query: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 758
++ + Q + + S+R N+ C+ + ++ L ++ LP G
Sbjct: 1344 LPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD 1403
Query: 759 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK 818
+ E G N S GQ+Q LARA + I + D+ +++D ++I + V+
Sbjct: 1404 AVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVV--MTAFA 1460
Query: 819 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAFAEFLRT 868
++T + + H +S + +++V S G + E + LLA ++G F+ + T
Sbjct: 1461 DRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1511
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 672 bits (1734), Expect = 0.0
Identities = 425/1303 (32%), Positives = 677/1303 (51%), Gaps = 156/1303 (11%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
L FL +E+ DS ++ + + K G +
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
Query: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
Query: 740 VIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD 799
V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D
Sbjct: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
Query: 800 AHVGKHIFENVIGPKGMLK-----NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 854
H+ H+ + +G+LK +T +LVTH + YL D II M G + G+ ++
Sbjct: 844 IHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD 898
Query: 855 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL 914
+ +D E +T + Q+Q+ E++ EA Q L+R+
Sbjct: 899 IQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKT 936
Query: 915 SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI 974
+ YS + E ++ E +++ M ++ W Y+ + G F+
Sbjct: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFL 993
Query: 975 SFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAV 1030
L IF + H +A +YWL+ WT + +N T Q + S+ GI +
Sbjct: 994 LILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT 1053
Query: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP
Sbjct: 1054 ---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT 1110
Query: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
++ S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P
Sbjct: 1111 LESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLP 1170
Query: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
+ HF+ET G++ IRAF + RF + D N AY ANRWL VR + +G CI
Sbjct: 1171 LLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
Query: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
VL A++ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ +
Sbjct: 1231 VLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1288
Query: 1271 EKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
E E + + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRT
Sbjct: 1289 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1348
Query: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
G+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLD
Sbjct: 1349 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1408
Query: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
P + +D+ +W +LE+A LK+ V +LP LD EGGEN V
Sbjct: 1409 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSV 1451
Score = 85.1 bits (209), Expect = 4e-16
Identities = 139/651 (21%), Positives = 259/651 (39%), Gaps = 88/651 (13%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
+ + P L + I G V + G+ G GKSSL A +D +G + I G
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISK 1379
Query: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 758
++ + Q + + S+R N+ C+ + ++ L ++ LP G
Sbjct: 1380 LPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD 1439
Query: 759 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK 818
+ E G N S GQ+Q LARA + I + D+ +++D ++I + V+
Sbjct: 1440 AVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVV--MTAFA 1496
Query: 819 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAFAEFLRT 868
++T + + H +S + +++V S G + E + LLA ++G F+ + T
Sbjct: 1497 DRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1547
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 672 bits (1734), Expect = 0.0
Identities = 425/1303 (32%), Positives = 677/1303 (51%), Gaps = 156/1303 (11%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
L FL +E+ DS ++ + + K G +
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
Query: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
Query: 740 VIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD 799
V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D
Sbjct: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
Query: 800 AHVGKHIFENVIGPKGMLK-----NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 854
H+ H+ + +G+LK +T +LVTH + YL D II M G + G+ ++
Sbjct: 844 IHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD 898
Query: 855 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL 914
+ +D E +T + Q+Q+ E++ EA Q L+R+
Sbjct: 899 IQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKT 936
Query: 915 SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI 974
+ YS + E ++ E +++ M ++ W Y+ + G F+
Sbjct: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFL 993
Query: 975 SFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAV 1030
L IF + H +A +YWL+ WT + +N T Q + S+ GI +
Sbjct: 994 LILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT 1053
Query: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP
Sbjct: 1054 ---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT 1110
Query: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
++ S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P
Sbjct: 1111 LESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLP 1170
Query: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
+ HF+ET G++ IRAF + RF + D N AY ANRWL VR + +G CI
Sbjct: 1171 LLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
Query: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
VL A++ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ +
Sbjct: 1231 VLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1288
Query: 1271 EKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
E E + + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRT
Sbjct: 1289 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1348
Query: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
G+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLD
Sbjct: 1349 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1408
Query: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
P + +D+ +W +LE+A LK+ V +LP LD EGGEN V
Sbjct: 1409 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSV 1451
Score = 93.2 bits (230), Expect = 2e-18
Identities = 143/650 (22%), Positives = 261/650 (40%), Gaps = 88/650 (13%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
+ + P L + I G V + G+ G GKSSL A +D +G + I G
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISK 1379
Query: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 758
++ + Q + + S+R N+ C+ + ++ L ++ LP G
Sbjct: 1380 LPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD 1439
Query: 759 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK 818
+ E G N S GQ+Q LARA + I + D+ +++D ++I + V+
Sbjct: 1440 AVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVV--MTAFA 1496
Query: 819 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD-GAFAEFLR 867
++T + + H + + D++IVM G I E + + LLA++ G FA F+R
Sbjct: 1497 DRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 670 bits (1728), Expect = 0.0
Identities = 429/1323 (32%), Positives = 680/1323 (51%), Gaps = 172/1323 (13%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
Query: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Q K + ++ ++++ L FG ++S
Sbjct: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Query: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
Query: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
Query: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
VS+++L FLS E+ + +RP +
Sbjct: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
Query: 637 ------DGGGTNS-ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
Query: 690 ALLAEMDKVEGHV--------------------------AIKGSVAYVPQQAWIQNDSLR 723
A L EM KV G V +G VAY Q+ W+ N ++
Sbjct: 725 AALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVE 784
Query: 724 ENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
ENI+F + Y+ VI+AC+L PD++ILP GD+T+IGE+G+NLSGGQ+QR+S+ARA+Y
Sbjct: 785 ENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALY 844
Query: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
+A++ DDP SA+D H+ H+ + I +T +LVTH + YLP D II M
Sbjct: 845 QHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD 904
Query: 844 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVT 903
G I G+ ++ + E +T + Q+Q+ E+ VT ++A + G
Sbjct: 905 GTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETVTE-----RKATEPPQG---- 954
Query: 904 DSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVY 963
L R +SS D E ++ EA + E + + Q ++
Sbjct: 955 ------LSRAMSSRDGLLQD--------EEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
Query: 964 WDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIV--------NGTQEHT--- 1012
Y+ + G+ + L +F + H+ +A +YWL+ WTD + + +QE T
Sbjct: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQ 1060
Query: 1013 ---KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPS 1069
+ +V +LGI + S+ V G+ ++ LH LL+ I+ +PM FFE TP
Sbjct: 1061 TVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPL 1117
Query: 1070 GNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV 1129
G+++NRFS + +T+D IP ++ S + A VI TP+ + + PL ++ +F+
Sbjct: 1118 GSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFI 1177
Query: 1130 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1189
Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF + RF + D N A
Sbjct: 1178 QKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1237
Query: 1190 YPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSAGLVGLSVSYSLQVTTYLNWL 1247
ANRWL VR+E +G C+VL AA+ ++ + LSAGLVGL ++Y+L V+ YLNW+
Sbjct: 1238 LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297
Query: 1248 VRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDL 1306
VR ++ME + AV+R+ +TE E+ + + P +WP G+++ +N +RY L
Sbjct: 1298 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL 1357
Query: 1307 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1366
VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++ EG IIIDGI+IAK+ LH L
Sbjct: 1358 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417
Query: 1367 RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEG 1426
R +++II QDPVLFSG++R NLDP + SD +W +LE+A LK V ALP LD EG
Sbjct: 1418 RSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEG 1477
Query: 1427 GEN 1429
GEN
Sbjct: 1478 GEN 1480
Score = 92.8 bits (229), Expect = 2e-18
Identities = 119/535 (22%), Positives = 229/535 (42%), Gaps = 56/535 (10%)
Query: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
Query: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
Query: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
Query: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
Query: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I G
Sbjct: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 707 -SVAYVP------------QQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEIL 753
+A +P Q + + ++R N+ + + ++ L ++ L
Sbjct: 1407 IDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKAL 1466
Query: 754 PSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP 813
P G I E G N S GQ+Q LARA I++ D+ +++D ++I + V+
Sbjct: 1467 PGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATENILQKVV-- 1523
Query: 814 KGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 867
++T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 1524 MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 622 bits (1604), Expect = e-178
Identities = 409/1293 (31%), Positives = 652/1293 (50%), Gaps = 143/1293 (11%)
Query: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
Query: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
+ P+K SL V++K L
Sbjct: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
Query: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
M + +M GP IL +++ T W G + LF T + +
Sbjct: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
Query: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
Query: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
Query: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS- 419
Query: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
P S +P + + NAT TW +
Sbjct: 420 -PPSYITQPEDPD---TVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
Query: 657 DPPT----------------LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
Query: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 760
VA+ G++AYV QQAWI + ++RENILFG + + Y+ ++ C L DL LP GD TE
Sbjct: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
Query: 761 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 820
IGE+G+NLSGGQ+QR+SLARAVYS+ +YL DDPLSAVDAHVGKH+FE I K L+ K
Sbjct: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653
Query: 821 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 880
T +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEH 712
Query: 881 NGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA 937
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 713 LYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD-------------- 758
Query: 938 EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI-GLFISFLSIFLFMCNHVSALASNYWL 996
K +L++ + Q G V Y Y+KA G +S ++FLF+ SA SN+WL
Sbjct: 759 --TKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWL 816
Query: 997 SLWTD-------DPIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIG------ 1040
LW D P N T L+ G + VF V+ G
Sbjct: 817 GLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKT 876
Query: 1041 GILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN 1100
++AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 877 TLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFM 936
Query: 1101 VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL 1160
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 937 VVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQ 996
Query: 1161 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
G+ +I A+ ++E I L + A RW A+R++ + N + AL +
Sbjct: 997 GLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTL 1046
Query: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQ 1279
S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1047 SFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLK 1106
Query: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLG 1339
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1107 VGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMA 1166
Query: 1340 LFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV 1399
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +
Sbjct: 1167 LFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEML 1226
Query: 1400 WTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
W LE ++D + LP+KL E E GEN V
Sbjct: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSV 1259
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 19/246 (7%)
Query: 636 KDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 695
KD IT R+ + + P L+ + +I G V +VG+ G GKSSL AL +
Sbjct: 1112 KDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLV 1171
Query: 696 DKVEGHVAI-------------KGSVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVI 741
+ G + I + + +PQ + ++R N+ F +E ++ V+
Sbjct: 1172 EPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQ-VL 1230
Query: 742 QACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAH 801
+ + + LP + E+ E G N S G++Q + +ARA+ N+ I L D+ +++D+
Sbjct: 1231 ERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSK 1290
Query: 802 VGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DG 860
+ +N I K K T + + H ++ + D ++VM GK+ E + L + D
Sbjct: 1291 TDT-LVQNTI--KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDS 1347
Query: 861 AFAEFL 866
AFA L
Sbjct: 1348 AFAMLL 1353
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 620 bits (1599), Expect = e-177
Identities = 388/1192 (32%), Positives = 619/1192 (51%), Gaps = 125/1192 (10%)
Query: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Query: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Query: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
Query: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
Query: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
Query: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
+ +++A VSL R+++FL P + G + + + A
Sbjct: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
Query: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
Query: 706 G---SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIG 762
G Q+ WIQ ++R+NILFG + Y+ V++ACAL DL ILP+GD+TE+G
Sbjct: 633 GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
Query: 763 EKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR 822
EKGV LSGGQ+ R++LARAVY ++YL DDPL+AVDA V H+ I GML TR
Sbjct: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTR 750
Query: 823 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENG 882
+L TH YL + D +++M G++ G E+L A + A E Q+++
Sbjct: 751 LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSAT 805
Query: 883 VTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKE 942
V P K + +E +++ L + E+KKE
Sbjct: 806 AQSVQNPEKTKEGLE----------------------------EEQSTSGRLLQEESKKE 837
Query: 943 ETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD 1002
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 838 -------------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQ 884
Query: 1003 -PIVNGTQE-----------------------------------------HTKVRLSVYG 1020
N +QE + L+VY
Sbjct: 885 LKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYA 944
Query: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
+ + ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++
Sbjct: 945 TIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDV 1004
Query: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
D +P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L
Sbjct: 1005 ACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSREL 1064
Query: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
+RL S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL
Sbjct: 1065 RRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLD 1124
Query: 1201 VRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
+RL+ +G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +
Sbjct: 1125 IRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAML 1184
Query: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
V+VERL+EY+ + P Q Q + W G VEF++ L YR L L + +
Sbjct: 1185 VSVERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQ 1243
Query: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
GEK+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P
Sbjct: 1244 PGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPF 1303
Query: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
LFSG++R NLDP + D +W +L+ HL + ++++ LD E EGG +L
Sbjct: 1304 LFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSL 1354
Score = 90.5 bits (223), Expect = 1e-17
Identities = 114/500 (22%), Positives = 219/500 (43%), Gaps = 60/500 (12%)
Query: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM 476
++ G I+N S D D +I L ++LA L L + +G+ ++L+
Sbjct: 990 ATPTGRILNRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLL 1042
Query: 477 VPVNAVMAMKTKTYQVAHMKSKDNRIKL--------MNEILNGIKVLKLYAWELAFKDKV 528
+P ++M + + A + L + + L G+ VL+ F+++
Sbjct: 1043 LPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEEN 1102
Query: 529 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLAL 588
L + + L + + T W+ + L AV I ++ Q + L
Sbjct: 1103 LRLLE-----LNQRCQFATSATMQWL--DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL 1155
Query: 589 FNI-LRFPLNI---LPMVISSIVQAS---VSLKRLRIFLSHEELEPDSIERRPVKDGGG- 640
+ L + L++ L ++SS Q VS++RL + EP +P++ G G
Sbjct: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG---QPLQLGTGW 1212
Query: 641 --TNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKV 698
+ ++ + P L+G+TF + G + +VG+ G GKSSLL L ++
Sbjct: 1213 LTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
Query: 699 EGHVAIKG-------------SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQAC 744
G V + G +A +PQ+ ++ + ++REN+ G + ++++ Q C
Sbjct: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ-C 1331
Query: 745 ALLPDLEILPS--GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 802
L E++ S G E+GE G +LS GQ+Q + LARA+ ++A I D+ ++VD
Sbjct: 1332 HL---SEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
Query: 803 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
+ + + + NKT + + H ++ + D ++V+ G++ E+ S L R+
Sbjct: 1389 DQLLQQTIC---KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL--RNQPH 1443
Query: 863 AEFLRTYASTEQEQDAEENG 882
+ F + S++Q A G
Sbjct: 1444 SLFQQLLQSSQQGVPASLGG 1463
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCT 564
TFTW+C+PFLV L T
Sbjct: 534 TTTFTWMCSPFLVRLGT 550
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 550 bits (1416), Expect = e-156
Identities = 378/1285 (29%), Positives = 623/1285 (48%), Gaps = 142/1285 (11%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828
SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
Query: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885
+ YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
Query: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945
E ++E+ L T S S +G+ H T E
Sbjct: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
Query: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
Query: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048
+ + ++ G + + ++ V+G + + V GI AS L
Sbjct: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
Query: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108
H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++
Sbjct: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
Query: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168
+ +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I +
Sbjct: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
Query: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228
+ E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
Query: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W
Sbjct: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
Query: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347
PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E
Sbjct: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
Query: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407
G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255
Query: 1408 LKDFVSALPDKLDHECAEGGENLRV 1432
L +S P KL + E G N V
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSV 1280
Score = 79.7 bits (195), Expect = 2e-14
Identities = 103/514 (20%), Positives = 213/514 (41%), Gaps = 58/514 (11%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719
+V +VG+ G GKSSL AL ++ + G + I G ++ +PQ + +
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
Query: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLA 779
++R N+ + + ++ L + P T++ E G N S G++Q + +A
Sbjct: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIA 1289
Query: 780 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
RAV N+ I L D+ +++D I + + + T +++ H ++ + D I+
Sbjct: 1290 RAVLRNSKIILIDEATASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHIL 1346
Query: 840 VMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 872
VM GK+ E + L + G+ FA + T S+
Sbjct: 1347 VMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 550 bits (1416), Expect = e-156
Identities = 378/1285 (29%), Positives = 623/1285 (48%), Gaps = 142/1285 (11%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828
SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
Query: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885
+ YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
Query: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945
E ++E+ L T S S +G+ H T E
Sbjct: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
Query: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
Query: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048
+ + ++ G + + ++ V+G + + V GI AS L
Sbjct: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
Query: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108
H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++
Sbjct: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
Query: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168
+ +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I +
Sbjct: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
Query: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228
+ E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
Query: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W
Sbjct: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
Query: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347
PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E
Sbjct: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
Query: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407
G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255
Query: 1408 LKDFVSALPDKLDHECAEGGENLRV 1432
L +S P KL + E G N V
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSV 1280
Score = 79.7 bits (195), Expect = 2e-14
Identities = 103/514 (20%), Positives = 213/514 (41%), Gaps = 58/514 (11%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719
+V +VG+ G GKSSL AL ++ + G + I G ++ +PQ + +
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
Query: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLA 779
++R N+ + + ++ L + P T++ E G N S G++Q + +A
Sbjct: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIA 1289
Query: 780 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
RAV N+ I L D+ +++D I + + + T +++ H ++ + D I+
Sbjct: 1290 RAVLRNSKIILIDEATASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHIL 1346
Query: 840 VMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 872
VM GK+ E + L + G+ FA + T S+
Sbjct: 1347 VMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 550 bits (1416), Expect = e-156
Identities = 317/790 (40%), Positives = 462/790 (58%), Gaps = 51/790 (6%)
Query: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQN 719
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G+ AYV QQAWI N
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
Query: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLA 779
+LR+NILFG + +E Y SV+ +C L PDL ILPS D TEIGE+G NLSGGQ+QR+SLA
Sbjct: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
Query: 780 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
RA+YS+ IY+ DDPLSA+DAHVG HIF + I + LK+KT + VTH + YL D +I
Sbjct: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTHQLQYLVDCDEVI 754
Query: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
M G I+E G+++EL+ +G +A E E N SG K+++
Sbjct: 755 FMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP-VEINSKKETSGSQKKSQ----- 808
Query: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
D K T ++K +A K E +L++ ++ G V
Sbjct: 809 ----DKGPK----------------------TGSVKKEKAVKPEEGQLVQLEEKGQGSVP 842
Query: 960 LSVYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWTDDPIVNGTQ---EHTKVR 1015
SVY Y++A G ++FL I LFM N S S +WLS W N T T V
Sbjct: 843 WSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS 902
Query: 1016 LSVYGALGISQGIAVFGYSMAVSI------------GGILASRCLHVDLLHSILRSPMSF 1063
S+ + +++ SMAV + G + AS LH +L ILRSPM F
Sbjct: 903 DSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKF 962
Query: 1064 FERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLG 1123
F+ TP+G ++NRFSK++D VD +P +MF+ ++ V +I P + + PL
Sbjct: 963 FDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022
Query: 1124 LIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVD 1183
+++ + R+LKRL+++++SP SH ++ G++ I A+ + + F+H+ +D
Sbjct: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD 1082
Query: 1184 ENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTY 1243
+NQ ++ A RWLAVRL+ + ++ L V+ + GL++SY++Q+T
Sbjct: 1083 DNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142
Query: 1244 LNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY 1302
+ VR++SE E +VER+ Y +T EAP +I+ AP WPQ G V F N +RY
Sbjct: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
Query: 1303 REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG 1362
RE+L VL+ ++ TI EK+GIVGRTG+GKSSL + LFR+ E + G I IDG+ I+ IG
Sbjct: 1203 RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIG 1262
Query: 1363 LHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1422
L DLR K++IIPQ+PVLFSG++R NLDPF+QY+++++W +LE H+K+ ++ LP KL+ E
Sbjct: 1263 LADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESE 1322
Query: 1423 CAEGGENLRV 1432
E G+N V
Sbjct: 1323 VMENGDNFSV 1332
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
Query: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
D A SL +V++ ++
Sbjct: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
Query: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
Query: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
Query: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
Query: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
Query: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
I+ +P I ++NAT W S
Sbjct: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
Score = 77.4 bits (189), Expect = 9e-14
Identities = 107/541 (19%), Positives = 223/541 (41%), Gaps = 52/541 (9%)
Query: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
Query: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
Query: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
++ + W+ + + T + + + I A ++ L
Sbjct: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
Query: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG- 706
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I G
Sbjct: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
Query: 707 ------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILP 754
++ +PQ+ + + ++R N+ Q E ++ + + LP
Sbjct: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
Query: 755 SGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPK 814
+E+ E G N S G++Q + +ARA+ + I + D+ +A+D I E + +
Sbjct: 1317 LKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---R 1373
Query: 815 GMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQ 874
+ T + + H + + D I+V++ G++ E + LL+ D + F +A+ E
Sbjct: 1374 EAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS--SRFYAMFAAAEN 1431
Query: 875 E 875
+
Sbjct: 1432 K 1432
Score = 40.0 bits (92), Expect = 0.017
Identities = 34/125 (27%), Positives = 51/125 (40%), Gaps = 13/125 (10%)
Query: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
Query: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1426 GGENL 1430
G NL
Sbjct: 681 RGANL 685
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 537 bits (1383), Expect = e-152
Identities = 370/1261 (29%), Positives = 613/1261 (48%), Gaps = 142/1261 (11%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828
SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
Query: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885
+ YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
Query: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945
E ++E+ L T S S +G+ H T E
Sbjct: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
Query: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
Query: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048
+ + ++ G + + ++ V+G + + V GI AS L
Sbjct: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
Query: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108
H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++
Sbjct: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
Query: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168
+ +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I +
Sbjct: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
Query: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228
+ E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
Query: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W
Sbjct: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
Query: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347
PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E
Sbjct: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
Query: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407
G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255
Query: 1408 L 1408
L
Sbjct: 1256 L 1256
Score = 42.7 bits (99), Expect = 0.003
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 13/121 (10%)
Query: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1430 L 1430
L
Sbjct: 634 L 634
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 447 bits (1149), Expect = e-125
Identities = 291/914 (31%), Positives = 472/914 (51%), Gaps = 100/914 (10%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
Query: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
G+Y E L F L+ + +++E+ V G + N
Sbjct: 614 KGTYTEFLKSGIDFGSLLK-----KDNEESEQPPVPG-------TPTLRN---------- 651
Query: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
R S SS +S SR L+ + E + + G+V Y +Y +
Sbjct: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDT--ENVPVTLSEENRSEGKVGFQAYKNYFR 706
Query: 969 AIGLFISFLSIFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
A +I F IFL + N V+ + ++WLS W + + VNG T+ +L +
Sbjct: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
Query: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
Query: 1075 RFSKELDTVDSMIP 1088
RFSK++ +D ++P
Sbjct: 824 RFSKDIGHLDDLLP 837
Score = 50.8 bits (120), Expect = 9e-06
Identities = 78/379 (20%), Positives = 151/379 (39%), Gaps = 31/379 (8%)
Query: 1048 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1103
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
Query: 1104 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1163
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
Query: 1164 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1222
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
Query: 1223 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1278
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
Query: 1279 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
Query: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1398
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 1399 VWTSLELAHLKDFVSALPD 1417
++ LK + L D
Sbjct: 504 YEKVIKACALKKDLQLLED 522
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 259 bits (662), Expect = 1e-68
Identities = 178/709 (25%), Positives = 317/709 (44%), Gaps = 86/709 (12%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
+ NP L L + F F+
Sbjct: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
Query: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
Query: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
Query: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
Query: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
Query: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
+ ++ T + + N T W
Sbjct: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
Query: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714
P L I F I G L+AV G G GK+SLL ++ E++ EG + G +++ Q
Sbjct: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
Query: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQ 774
+WI +++ENI+FG +E YRSVI+AC L D+ D +GE G+ LSGGQ+
Sbjct: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
Query: 775 RVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 834
R+SLARAVY +AD+YL D P +D K IFE+ + ++ NKTRILVT M +L +
Sbjct: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
Query: 835 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 883
D I+++ G G++ EL F+ L S +Q N +
Sbjct: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
Score = 204 bits (519), Expect = 5e-52
Identities = 122/429 (28%), Positives = 224/429 (52%), Gaps = 22/429 (5%)
Query: 1019 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1076
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Query: 1077 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1136
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
Query: 1137 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1196
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
Query: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1256
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1097 RWFQMRIEMI-FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
Query: 1257 NIVAVERLKEYSE-------TEKEAPW-----------QIQETAPPSSWPQVGRVEFRNY 1298
+ +V R+ ++ + T+ P+ + WP G++ ++
Sbjct: 1156 LMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
Query: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL-LNTEGEIQIDGVSW 1274
Query: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDK 1418
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P K
Sbjct: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
Query: 1419 LDHECAEGG 1427
LD +GG
Sbjct: 1335 LDFVLVDGG 1343
Score = 75.9 bits (185), Expect = 3e-13
Identities = 68/253 (26%), Positives = 113/253 (44%), Gaps = 19/253 (7%)
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
Query: 685 SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ 731
S+LLSA L ++ EG + I G + +PQ+ +I + + R+N+ Q
Sbjct: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQ 1309
Query: 732 LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLF 791
+ V L +E P + + G LS G KQ + LAR+V S A I L
Sbjct: 1310 WSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLL 1369
Query: 792 DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS 851
D+P + +D V I + K + T IL H + + + +V+ K+ + S
Sbjct: 1370 DEPSAHLDP-VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDS 1426
Query: 852 YQELLARDGAFAE 864
Q+LL F +
Sbjct: 1427 IQKLLNERSLFRQ 1439
Score = 41.6 bits (96), Expect = 0.006
Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 1369 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1428
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
Query: 1429 NL 1430
L
Sbjct: 547 TL 548
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 155 bits (393), Expect = 2e-37
Identities = 189/846 (22%), Positives = 355/846 (41%), Gaps = 88/846 (10%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS + K ++ RN F++ +R + L G+ + G VA+VG GCGKS+
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGCQ-L 732
+ + D EG V++ G + V Q+ + ++ ENI +G + +
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
+ SA+D + + K +T I++ H +S + DVI G I E G++
Sbjct: 556 EATSALDTESEAVV---QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNH 612
Query: 853 QELLARDGAFAEFLRTYAS---TEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQ 909
EL+ G + + + + E E A+E+ E +E M DS
Sbjct: 613 DELMKEKGIYFKLVTMQTAGNEVELENAADES--------KSEIDALE--MSSNDSRSSL 662
Query: 910 LQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKA 969
++++ + S ST E W++M+ + + W Y
Sbjct: 663 IRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTE---------WPYF-V 712
Query: 970 IGLFISFLSIFLFMCNHVSALASNYWLSLWT--DDPIVNGTQEHTKVRLSVYGALGISQG 1027
+G+F + ++ L A+ + + ++T DDP ++++ + ++ ALGI
Sbjct: 713 VGVFCAIINGGL---QPAFAIIFSKIIGVFTRIDDP--ETKRQNSNLFSLLFLALGIISF 767
Query: 1028 IAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDS 1085
I F G + ++ L + S+LR +S+F+ + +G L R + + V
Sbjct: 768 ITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKG 827
Query: 1086 MIPEVIKMFMGSLFNVIGACIVILL-----ATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
I + + ++ N +G I+I T + I+P + + V + S + L
Sbjct: 828 AIGSRLAVITQNIAN-LGTGIIISFIYGWQLTLLLLAIVPIIAIA--GVVEMKMLSGQAL 884
Query: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQ--SDLKV---DENQKAYYPSIVA 1195
K + + S + E + + + ++++F H L+V + +KA+ I
Sbjct: 885 KDKKELEGSGKIA--TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITF 942
Query: 1196 NRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSL----QVTTYLNWLVRMS 1251
+ A+ C A L A LV +V + QV+++ +
Sbjct: 943 SFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAK 1002
Query: 1252 SEMETNIVAVER--LKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY--REDLD 1307
I+ +E+ L + TE P ++ G V F Y R D+
Sbjct: 1003 ISAAHIIMIIEKTPLIDSYSTEGLMPNTLE-----------GNVTFGEVVFNYPTRPDIP 1051
Query: 1308 FVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR 1367
VL+ +++ + G+ + +VG +G GKS++ L R + G++++DG I ++ + LR
Sbjct: 1052 -VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLR 1110
Query: 1368 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1424
+ I+ Q+P+LF S+ N+ D S EE+ + + A++ F+ +LP+K +
Sbjct: 1111 AHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVG 1170
Query: 1425 EGGENL 1430
+ G L
Sbjct: 1171 DKGTQL 1176
Score = 119 bits (298), Expect = 2e-26
Identities = 117/484 (24%), Positives = 210/484 (43%), Gaps = 59/484 (12%)
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV-LAGVAVMVLMVPV 479
G I + ++V Q +L T I + + Q L LL L + P + +AGV M ++
Sbjct: 827 GAIGSRLAVITQNIANLGTGIIISFIYGWQ----LTLLLLAIVPIIAIAGVVEMKML--- 879
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELK-V 538
+ A+K K K + K+ E + + + E F+ Q +
Sbjct: 880 -SGQALKDK-------KELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS 931
Query: 539 LKKSAYLSAVGTFTWVCTPFLVALC-TFAVYVTIDENNILDAQTAFVSLALFNILRFPLN 597
L+K+ +FT F A C F Y+ + + S +F
Sbjct: 932 LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGA------ 985
Query: 598 ILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---------SITVRN 648
M + + + + +I +H + IE+ P+ D T ++T
Sbjct: 986 ---MAVGQVSSFAPDYAKAKISAAHIIM---IIEKTPLIDSYSTEGLMPNTLEGNVTFGE 1039
Query: 649 ATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS 707
F + R D P L G++ + +G +A+VG GCGKS+++ L D + G V + G
Sbjct: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Query: 708 -------------VAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACA---LLPDLE 751
+ V Q+ + + S+ ENI +G +++A + +E
Sbjct: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIE 1159
Query: 752 ILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVI 811
LP+ T++G+KG LSGGQKQR+++ARA+ I L D+ SA+D K + E +
Sbjct: 1160 SLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1219
Query: 812 GPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS 871
+ + +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A
Sbjct: 1220 KAR---EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAG 1276
Query: 872 TEQE 875
T+++
Sbjct: 1277 TKRQ 1280
Score = 87.4 bits (215), Expect = 9e-17
Identities = 103/428 (24%), Positives = 187/428 (43%), Gaps = 36/428 (8%)
Query: 1023 GISQGIAVFGYSMAVSIGGILASRCLHV---DLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
GI G+ V Y + VS + A R +H H+I+R + +F+ G L R + +
Sbjct: 120 GIGAGVLVAAY-IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDD 178
Query: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVA 1135
+ ++ I + I MF S+ IV T + I P LGL + +
Sbjct: 179 VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAK--IL 236
Query: 1136 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQK-AYYPSIV 1194
SS K L + +++ + E L + + AF Q++ + + + ++E ++ +I
Sbjct: 237 SSFTDKELLAYAKAGAVA--EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT 294
Query: 1195 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVG-------LSVSYSLQVTTYLNWL 1247
AN +G +L A +A+ + + L G L+V +S+ + +
Sbjct: 295 AN-------ISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
Query: 1248 VRMSSEMETNI--VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY--R 1303
S E N A E K + P + G +EFRN Y R
Sbjct: 348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI---KGNLEFRNVHFSYPSR 404
Query: 1304 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1363
+++ +L+ +N+ + G+ V +VG +G GKS+ + R+ + EG + +DG +I I +
Sbjct: 405 KEVK-ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 1364 HDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1422
LR I ++ Q+PVLF+ ++ N+ + +E+ +++ A+ DF+ LP K D
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 1423 CAEGGENL 1430
E G L
Sbjct: 524 VGERGAQL 531
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 155 bits (391), Expect = 4e-37
Identities = 206/864 (23%), Positives = 356/864 (41%), Gaps = 100/864 (11%)
Query: 628 DSIERRPVKDGGGTNS---------ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVV 677
++I+R+P+ D + I N TF + +R + LN + I G + A+V
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 678 GQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRE 724
G G GKS+ L + D EG V + G + V Q+ + + ++ E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 725 NILFGCQLEEPYYRSVIQACALLPDLEI---LPSGDRTEIGEKGVNLSGGQKQRVSLARA 781
NI +G E+ ++QA LP T +GE G +SGGQKQRV++ARA
Sbjct: 515 NIRYG--REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARA 572
Query: 782 VYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVM 841
+ N I L D SA+D + + + + V+ + T I V H +S + D II
Sbjct: 573 LIRNPKILLLDMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGF 629
Query: 842 SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML 901
G E G+++ELL R G + F ++ Q E + + A+ G
Sbjct: 630 EHGTAVERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGS- 686
Query: 902 VTDSAGKQLQRQLSSSSSYSGD----ISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQ 957
DS ++++ S SY H ST E + K ++ E + A +
Sbjct: 687 YQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYE---EDRKDKDIPVQEEVEPAPVRR 743
Query: 958 V-KLSV-YWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 1015
+ K S W YM +G S+ + V+ L + + + I + ++ +++
Sbjct: 744 ILKFSAPEWPYM-LVG------SVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQIN 796
Query: 1016 --LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGN 1071
++ A+G F A + G L ++ L ++L +++F+ R G
Sbjct: 797 GVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGA 856
Query: 1072 LVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII----PPLGLIYF 1127
L R + + V I M + S NV A I+ + +++I P L L
Sbjct: 857 LTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGA 916
Query: 1128 FVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1186
R +SR + LE V + NE L + + ++ RFI + ++++
Sbjct: 917 TQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETELEKPF 971
Query: 1187 KAYYPSIVANRWLAVRLEC----------------VGNCIVLFAALFAVISRHSLSAGLV 1230
K + +C + N + F+ +F VIS LSA +
Sbjct: 972 KTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATAL 1031
Query: 1231 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQV 1290
G + SY+ S + I A + + +++ P + TA
Sbjct: 1032 GRAFSYT-------------PSYAKAKISAA---RFFQLLDRQPPISVYNTAGEKWDNFQ 1075
Query: 1291 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1349
G+++F + Y D VL ++V+I+ G+ + VG +G GKS+ L R + +G
Sbjct: 1076 GKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQG 1135
Query: 1350 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1406
+++IDG + K+ + LR I I+ Q+PVLF+ S+ N+ D + E V + + A
Sbjct: 1136 KVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQA 1195
Query: 1407 HLKDFVSALPDKLDHECAEGGENL 1430
L DFV +LP+K + G L
Sbjct: 1196 QLHDFVMSLPEKYETNVGSQGSQL 1219
Score = 107 bits (267), Expect = 8e-23
Identities = 75/235 (31%), Positives = 121/235 (51%), Gaps = 20/235 (8%)
Query: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG--- 706
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
Query: 707 ----------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC--ALLPDLEI-L 753
++ V Q+ + S+ +NI +G +E VI A A L D + L
Sbjct: 1145 KKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL 1204
Query: 754 PSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP 813
P T +G +G LS G+KQR+++ARA+ + I L D+ SA+D K + +
Sbjct: 1205 PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVAL 1261
Query: 814 KGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 868
+ +T I++ H +S + D+I VM+ G + E G+++EL+A+ GA+ + + T
Sbjct: 1262 DKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 136 bits (343), Expect = 1e-31
Identities = 175/832 (21%), Positives = 330/832 (39%), Gaps = 63/832 (7%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732
+ + D EG + I G + V Q+ + + ++ ENI +G +
Sbjct: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
Query: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
+ ++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
Query: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
+ SA+D + + + + +T I++ H +S + DVI G I E GS+
Sbjct: 558 EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
Query: 853 QELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR 912
EL+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 615 SELMKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKN 673
Query: 913 QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL 972
S + + +A K+++ +K + W Y +G
Sbjct: 674 SQMCQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGT 715
Query: 973 FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG 1032
+ + L S + S D V Q+ + ++ LGI F
Sbjct: 716 VCAIANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFL 771
Query: 1033 YSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEV 1090
G + +R L ++LR MS+F+ + +G L R + + V
Sbjct: 772 QGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTR 831
Query: 1091 IKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLES 1145
+ + ++ N+ I+ + T + ++P + + + ++ R K LE+
Sbjct: 832 LALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
Query: 1146 VSRSPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1202
+ + N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFM 948
Query: 1203 LECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1262
C A L +++ H ++ L S + L + + ++
Sbjct: 949 YFSYAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAA 1005
Query: 1263 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGE 1321
L E + +E P + G + F Y + VL+ +++ + G+
Sbjct: 1006 HLFMLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1063
Query: 1322 KVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFS 1381
+ +VG +G GKS++ L R + G +++DG K+ + LR ++ I+ Q+P+LF
Sbjct: 1064 TLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1123
Query: 1382 GSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
S+ N+ D S +E+ ++ + A++ F+ LP K + + G L
Sbjct: 1124 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1175
Score = 124 bits (311), Expect = 7e-28
Identities = 81/270 (30%), Positives = 132/270 (48%), Gaps = 30/270 (11%)
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDS---LRENILFGCQLEEPY 736
GCGKS+++ L D + G V + G A W++ +E ILF C + E
Sbjct: 1071 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1130
Query: 737 YR-------------SVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
S +A + P +E LP T +G+KG LSGGQKQR+++ARA+
Sbjct: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
Query: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
I L D+ SA+D K + E + + + +T I++ H +S + D+I+V
Sbjct: 1191 RQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNADLIVVFQN 1247
Query: 844 GKISEMGSYQELLARDGAFAEFLRTYASTE 873
G++ E G++Q+LLA+ G + + A T+
Sbjct: 1248 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
Score = 68.2 bits (165), Expect = 6e-11
Identities = 103/453 (22%), Positives = 190/453 (41%), Gaps = 31/453 (6%)
Query: 993 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 1050
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
Query: 1051 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1109
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
Query: 1110 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
Query: 1166 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
Query: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1279
S+ ++V +S+ + + + N A + + + + +
Sbjct: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
Query: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL-DPFSQYSDE 1397
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
Query: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
E+ +++ A+ +F+ LP K D E G L
Sbjct: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 132 bits (331), Expect = 3e-30
Identities = 101/350 (28%), Positives = 172/350 (49%), Gaps = 34/350 (9%)
Query: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
+ L+GI+F +P G VA+VG G GKS+++ L + +G + + G
Sbjct: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
Query: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI-LPSGD 757
+V VPQ A + ++++ N+L+G P + A L D + +P G
Sbjct: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGY 599
Query: 758 RTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP-KGM 816
T++GE+G+ LSGG+KQRV++ARA+ + + L+D+ S++D+ E ++G K +
Sbjct: 600 DTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE----ETILGAMKDV 655
Query: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLRTYASTEQE 875
+K++T I + H +S + D IIV+ GK++E G++ LLA ++E T +S Q
Sbjct: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQN 715
Query: 876 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDIS 925
D P EAK+ EN + + K+LQ ++ +S G+ S
Sbjct: 716 HD----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGCGNCS 752
Score = 82.0 bits (201), Expect = 4e-15
Identities = 63/203 (31%), Positives = 98/203 (48%), Gaps = 9/203 (4%)
Query: 1239 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1298
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Query: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Query: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1417
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
Query: 1418 KLDHECAE------GGENLRVIV 1434
D + E GGE RV +
Sbjct: 598 GYDTQVGERGLKLSGGEKQRVAI 620
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 129 bits (325), Expect = 2e-29
Identities = 175/839 (20%), Positives = 330/839 (39%), Gaps = 70/839 (8%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732
+ + D EG + I G + V Q+ + + ++ ENI +G +
Sbjct: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
Query: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
+ ++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
Query: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
+ SA+D + + + + +T I++ H +S + DVI G I E GS+
Sbjct: 558 EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
Query: 853 QELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR 912
EL+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 615 SELMKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKN 673
Query: 913 QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL 972
S + + +A K+++ +K + W Y +G
Sbjct: 674 SQMCQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGT 715
Query: 973 FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG 1032
+ + L S + S D V Q+ + ++ LGI F
Sbjct: 716 VCAIANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFL 771
Query: 1033 YSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEV 1090
G + +R L ++LR MS+F+ + +G L R + + V
Sbjct: 772 QGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTR 831
Query: 1091 IKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLES 1145
+ + ++ N+ I+ + T + ++P + + + ++ R K LE+
Sbjct: 832 LALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
Query: 1146 VSRSPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1202
+ + N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFM 948
Query: 1203 LECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1262
C A L +++ H ++ L S + L + + ++
Sbjct: 949 YFSYAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAA 1005
Query: 1263 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGE 1321
L E + +E P + G + F Y + VL+ +++ + G+
Sbjct: 1006 HLFMLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1063
Query: 1322 KVGIVGRTGAGKSSLTLGLFRINESAEGEI-------IIDGINIAKIGLHDLRFKITIIP 1374
+ +VG +G GKS++ L R + G + ++DG K+ + LR ++ I+
Sbjct: 1064 TLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVS 1123
Query: 1375 QDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
Q+P+LF S+ N+ D S +E+ ++ + A++ F+ LP K + + G L
Sbjct: 1124 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Score = 120 bits (300), Expect = 1e-26
Identities = 79/277 (28%), Positives = 135/277 (48%), Gaps = 37/277 (13%)
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAI--------------------KGSVAYVPQQAWIQN 719
GCGKS+++ L D + G V + + + V Q+ + +
Sbjct: 1071 SGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1130
Query: 720 DSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRV 776
S+ ENI +G + + S +A + P +E LP T +G+KG LSGGQKQR+
Sbjct: 1131 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI 1190
Query: 777 SLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVD 836
++ARA+ I L D+ SA+D K + E + + + +T I++ H +S + D
Sbjct: 1191 AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNAD 1247
Query: 837 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 873
+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 1248 LIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
Score = 68.2 bits (165), Expect = 6e-11
Identities = 103/453 (22%), Positives = 190/453 (41%), Gaps = 31/453 (6%)
Query: 993 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 1050
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
Query: 1051 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1109
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
Query: 1110 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
Query: 1166 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
Query: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1279
S+ ++V +S+ + + + N A + + + + +
Sbjct: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
Query: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL-DPFSQYSDE 1397
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
Query: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
E+ +++ A+ +F+ LP K D E G L
Sbjct: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 124 bits (311), Expect = 7e-28
Identities = 81/270 (30%), Positives = 132/270 (48%), Gaps = 30/270 (11%)
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 974 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1023
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDS---LRENILFGCQLEEPY 736
GCGKS+++ L D + G V + G A W++ +E ILF C + E
Sbjct: 1024 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1083
Query: 737 YR-------------SVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
S +A + P +E LP T +G+KG LSGGQKQR+++ARA+
Sbjct: 1084 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1143
Query: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
I L D+ SA+D K + E + + + +T I++ H +S + D+I+V
Sbjct: 1144 RQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNADLIVVFQN 1200
Query: 844 GKISEMGSYQELLARDGAFAEFLRTYASTE 873
G++ E G++Q+LLA+ G + + A T+
Sbjct: 1201 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
Score = 102 bits (255), Expect = 2e-21
Identities = 72/267 (26%), Positives = 123/267 (46%), Gaps = 18/267 (6%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732
+ + D EG + I G + V Q+ + + ++ ENI +G +
Sbjct: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
Query: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
+ ++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
Query: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
+ SA+D + + + + +T I++ H +S + DVI G I E GS+
Sbjct: 558 EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
Query: 853 QELLARDGAFAEFLRTYASTEQEQDAE 879
EL+ ++G + + + S Q Q E
Sbjct: 615 SELMKKEGVYFKLVNMQTSGSQIQSEE 641
Score = 68.2 bits (165), Expect = 6e-11
Identities = 103/453 (22%), Positives = 190/453 (41%), Gaps = 31/453 (6%)
Query: 993 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 1050
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
Query: 1051 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1109
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
Query: 1110 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
Query: 1166 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
Query: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1279
S+ ++V +S+ + + + N A + + + + +
Sbjct: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
Query: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL-DPFSQYSDE 1397
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
Query: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
E+ +++ A+ +F+ LP K D E G L
Sbjct: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
Score = 64.7 bits (156), Expect = 6e-10
Identities = 37/144 (25%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Query: 1291 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1349
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R + G
Sbjct: 985 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1044
Query: 1350 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1406
+++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ ++ + A
Sbjct: 1045 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1104
Query: 1407 HLKDFVSALPDKLDHECAEGGENL 1430
++ F+ LP K + + G L
Sbjct: 1105 NIHPFIETLPHKYETRVGDKGTQL 1128
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 119 bits (298), Expect = 2e-26
Identities = 114/496 (22%), Positives = 224/496 (45%), Gaps = 51/496 (10%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
Query: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
Query: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
G GKS++LS LL D G +++ G + V Q+ + + S+ ENI
Sbjct: 529 SGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENI 588
Query: 727 LFGCQLEEPYYRSVIQACALLPD----LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAV 782
+G IQ A + + + P G T +GEKGV LSGGQKQR+++ARA+
Sbjct: 589 AYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARAL 648
Query: 783 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 842
N I L D+ SA+DA +++ + + ++ +T +++ H +S + +++ V+
Sbjct: 649 LKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAVLD 705
Query: 843 GGKISEMGSYQELLAR 858
GKI+E G ++ELL++
Sbjct: 706 QGKITEYGKHEELLSK 721
Score = 100 bits (249), Expect = 1e-20
Identities = 103/417 (24%), Positives = 185/417 (44%), Gaps = 26/417 (6%)
Query: 1048 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1105
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
Query: 1106 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1162
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
Query: 1163 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA---V 1219
+RAF ++ I + KVD + A GN IVL + L+ +
Sbjct: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVL-SVLYKGGLL 420
Query: 1220 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1279
+ ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
Query: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
Query: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1394
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
Query: 1395 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEIQEYGAPSDLLQ 1451
+ EE+ E+A+ F+ P + E G ++L G+ Q LL+
Sbjct: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKG-----VLLSGGQKQRIAIARALLK 650
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,783,634
Number of Sequences: 37866
Number of extensions: 2209153
Number of successful extensions: 6418
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 5856
Number of HSP's gapped (non-prelim): 321
length of query: 1466
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1351
effective length of database: 13,892,928
effective search space: 18769345728
effective search space used: 18769345728
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.