Search of human proteins with 53759120

Search of human proteins with 53759120

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
         (515 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa...  1042   0.0  
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa...  1012   0.0  
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa...   938   0.0  
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     75   1e-13
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       66   9e-11
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       66   9e-11
gi|118766328 transmembrane and tetratricopeptide repeat containi...    57   5e-08
gi|118766330 transmembrane and tetratricopeptide repeat containi...    57   5e-08
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    52   1e-06
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    52   1e-06
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 52   2e-06
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         50   5e-06
gi|83415184 transmembrane and tetratricopeptide repeat containin...    49   1e-05
gi|224809432 transmembrane and tetratricopeptide repeat containi...    47   4e-05
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]           45   1e-04
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    44   3e-04
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    44   3e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ...    44   5e-04
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ...    44   5e-04
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ...    41   0.002
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap...    41   0.002
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap...    41   0.002
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap...    41   0.002
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]          40   0.007
gi|22749211 transmembrane and tetratricopeptide repeat containin...    39   0.011
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]            39   0.015
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]     37   0.043
gi|34304360 nephrocystin 3 [Homo sapiens]                              37   0.056
gi|118402596 cell division cycle protein 23 [Homo sapiens]             37   0.056
gi|40548372 tetratricopeptide repeat domain 15 [Homo sapiens]          36   0.096

>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
           sapiens]
          Length = 515

 Score = 1042 bits (2695), Expect = 0.0
 Identities = 515/515 (100%), Positives = 515/515 (100%)

Query: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE 60
           MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE
Sbjct: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE 60

Query: 61  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 120
           MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT
Sbjct: 61  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 120

Query: 121 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 180
           GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL
Sbjct: 121 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 180

Query: 181 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 240
           NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM
Sbjct: 181 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 240

Query: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300
           YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR
Sbjct: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300

Query: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360
           IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG
Sbjct: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
           QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF
Sbjct: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
           RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD
Sbjct: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480

Query: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 515
           LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 515


>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
           sapiens]
          Length = 505

 Score = 1012 bits (2616), Expect = 0.0
 Identities = 505/515 (98%), Positives = 505/515 (98%), Gaps = 10/515 (1%)

Query: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE 60
           MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ          AAWILKARALTE
Sbjct: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ----------AAWILKARALTE 50

Query: 61  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 120
           MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT
Sbjct: 51  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 110

Query: 121 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 180
           GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL
Sbjct: 111 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 170

Query: 181 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 240
           NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM
Sbjct: 171 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 230

Query: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300
           YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR
Sbjct: 231 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 290

Query: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360
           IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG
Sbjct: 291 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 350

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
           QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF
Sbjct: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
           RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD
Sbjct: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470

Query: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 515
           LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 471 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 505


>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
           sapiens]
          Length = 475

 Score =  938 bits (2424), Expect = 0.0
 Identities = 475/515 (92%), Positives = 475/515 (92%), Gaps = 40/515 (7%)

Query: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTE 60
           MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ          AAWILKARALTE
Sbjct: 1   MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQ----------AAWILKARALTE 50

Query: 61  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 120
           MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT
Sbjct: 51  MVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPIT 110

Query: 121 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRL 180
           GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTA                
Sbjct: 111 GFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTA---------------- 154

Query: 181 NLTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 240
                         LFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM
Sbjct: 155 --------------LFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGM 200

Query: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300
           YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR
Sbjct: 201 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 260

Query: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360
           IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG
Sbjct: 261 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 320

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
           QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF
Sbjct: 321 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 380

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
           RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD
Sbjct: 381 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 440

Query: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 515
           LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
Sbjct: 441 LQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML 475


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 3/270 (1%)

Query: 223 KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFK 282
           KDW     +G CY  L  + +A+ Q  +AL       T++ L K+++       A+ ++K
Sbjct: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192

Query: 283 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 342
           + ++  P    LL  +  +Y ++     A E+    L  D T+ +AI   GS        
Sbjct: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252

Query: 343 EIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYN 402
           ++AL  YR +      +  L+NN+G+C F  ++Y   ++  +RA  LA  + +   + YN
Sbjct: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK---ILYN 309

Query: 403 LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 462
           LG V + +     A      A+       E Y  LAV       +E A+     A  L  
Sbjct: 310 LGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDK 369

Query: 463 HMYEPHFNFATISDKIGDLQRSYVAAQKSE 492
                + N+A +    G+ + +    Q+ E
Sbjct: 370 CNPLVNLNYAVLLYNQGEKKNALAQYQEME 399



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/246 (17%), Positives = 99/246 (40%), Gaps = 9/246 (3%)

Query: 252 LKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSA 311
           L++Q  +    Y+ K Y +    +       QGL ++   V  L     I+    N+  +
Sbjct: 32  LEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQAL-----IFRLEGNIQES 86

Query: 312 AEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCF 371
            E ++          + +  +  + F   + + A+  Y    ++   + ++ +NLG+C  
Sbjct: 87  LELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI 146

Query: 372 YAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHA 431
           Y +Q++        AL+L  ++      +  LG + +  GD + A + ++ A+  +  + 
Sbjct: 147 YLKQFNKAQDQLHNALNLNRHDL----TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202

Query: 432 EAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKS 491
           E    L +L ++ G  ++A   L  A +  P  Y+      ++    GD   +    +  
Sbjct: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262

Query: 492 EAAFPD 497
             A P+
Sbjct: 263 ACAVPE 268


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 60/302 (19%), Positives = 121/302 (40%), Gaps = 32/302 (10%)

Query: 231 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
           +G  Y   G  +EA + ++ AL+ + + +D ++ LA   V+      A+  +   L   P
Sbjct: 85  LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144

Query: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
               +   +  + + +  +  A   Y + ++       A + +G       +  +A+  +
Sbjct: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204

Query: 350 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE----EAADVWYNLGH 405
            + + +       + NLG     A+ +D  + ++ RALSL+ N        A V+Y  G 
Sbjct: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264

Query: 406 VAVGI---------------------------GDTNLAHQCFRLALVNNNNHAEAYNNLA 438
           + + I                           G    A  C+  AL     HA++ NNLA
Sbjct: 265 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 324

Query: 439 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
            ++  +G++E+A  L + A  + P     H N A++  + G LQ + +  +++    P  
Sbjct: 325 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384

Query: 499 VD 500
            D
Sbjct: 385 AD 386



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 323
           LA VY        A++ +++ ++  P      C +A   +E  +++ A + Y   L+   
Sbjct: 255 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 314

Query: 324 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 383
           TH +++  + +        E A+R YR+ L++        +NL        +    L  +
Sbjct: 315 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374

Query: 384 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 443
           + A+ ++      AD + N+G+    + D   A QC+  A+  N   A+A++NLA +   
Sbjct: 375 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 431

Query: 444 KGHVEQARALLQTASSLAPHMYEPHFNFA 472
            G++ +A A  +TA  L P   + + N A
Sbjct: 432 SGNIPEAIASYRTALKLKPDFPDAYCNLA 460



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)

Query: 289 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 348
           P    +L  ++ I+ +   +  +A +    +KQ+    EA + +G+ +    Q + A+  
Sbjct: 42  PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101

Query: 349 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 408
           YR  L++       + NL      A   +  + ++  AL   +   +   V  +LG++  
Sbjct: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 158

Query: 409 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 468
            +G    A  C+  A+    N A A++NL  +   +G +  A    + A +L P+  + +
Sbjct: 159 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 218

Query: 469 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
            N   +  +     R+  A  ++ +  P+H
Sbjct: 219 INLGNVLKEARIFDRAVAAYLRALSLSPNH 248



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 40/208 (19%), Positives = 82/208 (39%), Gaps = 3/208 (1%)

Query: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL 352
           T L  +A    +  +  +A  +  ++ +Q+  +   +  + S HF   + + +  F    
Sbjct: 12  TGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLA 71

Query: 353 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 412
           ++      + ++NLG       Q    +  +  AL L   + +  D + NL    V  GD
Sbjct: 72  IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGD 128

Query: 413 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFA 472
              A Q +  AL  N +     ++L  L    G +E+A+A    A    P+      N  
Sbjct: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188

Query: 473 TISDKIGDLQRSYVAAQKSEAAFPDHVD 500
            + +  G++  +    +K+    P+ +D
Sbjct: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLD 216



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)

Query: 422 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 481
           LA+  N   AEAY+NL  +   +G +++A    + A  L P   + + N A      GD+
Sbjct: 70  LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 129

Query: 482 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 508
           +   ++YV+A Q +   +    D  +L+K L
Sbjct: 130 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 60/302 (19%), Positives = 121/302 (40%), Gaps = 32/302 (10%)

Query: 231 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
           +G  Y   G  +EA + ++ AL+ + + +D ++ LA   V+      A+  +   L   P
Sbjct: 95  LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 154

Query: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
               +   +  + + +  +  A   Y + ++       A + +G       +  +A+  +
Sbjct: 155 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 214

Query: 350 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE----EAADVWYNLGH 405
            + + +       + NLG     A+ +D  + ++ RALSL+ N        A V+Y  G 
Sbjct: 215 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 274

Query: 406 VAVGI---------------------------GDTNLAHQCFRLALVNNNNHAEAYNNLA 438
           + + I                           G    A  C+  AL     HA++ NNLA
Sbjct: 275 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 334

Query: 439 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
            ++  +G++E+A  L + A  + P     H N A++  + G LQ + +  +++    P  
Sbjct: 335 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 394

Query: 499 VD 500
            D
Sbjct: 395 AD 396



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 323
           LA VY        A++ +++ ++  P      C +A   +E  +++ A + Y   L+   
Sbjct: 265 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 324

Query: 324 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 383
           TH +++  + +        E A+R YR+ L++        +NL        +    L  +
Sbjct: 325 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 384

Query: 384 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 443
           + A+ ++      AD + N+G+    + D   A QC+  A+  N   A+A++NLA +   
Sbjct: 385 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 441

Query: 444 KGHVEQARALLQTASSLAPHMYEPHFNFA 472
            G++ +A A  +TA  L P   + + N A
Sbjct: 442 SGNIPEAIASYRTALKLKPDFPDAYCNLA 470



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)

Query: 289 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 348
           P    +L  ++ I+ +   +  +A +    +KQ+    EA + +G+ +    Q + A+  
Sbjct: 52  PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 111

Query: 349 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 408
           YR  L++       + NL      A   +  + ++  AL   +   +   V  +LG++  
Sbjct: 112 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 168

Query: 409 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 468
            +G    A  C+  A+    N A A++NL  +   +G +  A    + A +L P+  + +
Sbjct: 169 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 228

Query: 469 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
            N   +  +     R+  A  ++ +  P+H
Sbjct: 229 INLGNVLKEARIFDRAVAAYLRALSLSPNH 258



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 39/206 (18%), Positives = 81/206 (39%), Gaps = 3/206 (1%)

Query: 295 LCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQ 354
           L  +A    +  +  +A  +  ++ +Q+  +   +  + S HF   + + +  F    ++
Sbjct: 24  LAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIK 83

Query: 355 MGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTN 414
                 + ++NLG       Q    +  +  AL L   + +  D + NL    V  GD  
Sbjct: 84  QNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGDME 140

Query: 415 LAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATI 474
            A Q +  AL  N +     ++L  L    G +E+A+A    A    P+      N   +
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200

Query: 475 SDKIGDLQRSYVAAQKSEAAFPDHVD 500
            +  G++  +    +K+    P+ +D
Sbjct: 201 FNAQGEIWLAIHHFEKAVTLDPNFLD 226



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)

Query: 422 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 481
           LA+  N   AEAY+NL  +   +G +++A    + A  L P   + + N A      GD+
Sbjct: 80  LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 139

Query: 482 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 508
           +   ++YV+A Q +   +    D  +L+K L
Sbjct: 140 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 170


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)

Query: 280 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 339
           LF+  L   P    +   I +   +  N ++A  YY+E ++ +  +V A+  +G+     
Sbjct: 470 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529

Query: 340 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 399
           ++ + A       +Q+       + NLG+     ++++    S+  A+   ++  +  D 
Sbjct: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 586

Query: 400 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 459
           +YNLG +   +     A   +R A V    H+ A+NN+ +L    G++ QA A+ + A  
Sbjct: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646

Query: 460 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 497
           L P+ +   F+ A +  K    + S     K+  A P+
Sbjct: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)

Query: 233 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 291
           +C  R G +R  E+ F+SAL    +     Y + K          A+  +++ +   P  
Sbjct: 456 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 515

Query: 292 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 317
           V  +  +  I +E N +  A E                                   Y+ 
Sbjct: 516 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575

Query: 318 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 377
            +K    + +    +G  +   ++   AL  +R    +   +   +NN+ +         
Sbjct: 576 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 635

Query: 378 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 437
                   AL L  N+     + ++L +V         +   F  A+  N N A  + NL
Sbjct: 636 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 692

Query: 438 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 486
           AVL  R GH++ A+   + +  L P       N+  +  K+  +Q+  V
Sbjct: 693 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 741


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)

Query: 280 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 339
           LF+  L   P    +   I +   +  N ++A  YY+E ++ +  +V A+  +G+     
Sbjct: 489 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 548

Query: 340 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 399
           ++ + A       +Q+       + NLG+     ++++    S+  A+   ++  +  D 
Sbjct: 549 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 605

Query: 400 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 459
           +YNLG +   +     A   +R A V    H+ A+NN+ +L    G++ QA A+ + A  
Sbjct: 606 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 665

Query: 460 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 497
           L P+ +   F+ A +  K    + S     K+  A P+
Sbjct: 666 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 703



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)

Query: 233 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 291
           +C  R G +R  E+ F+SAL    +     Y + K          A+  +++ +   P  
Sbjct: 475 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 534

Query: 292 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 317
           V  +  +  I +E N +  A E                                   Y+ 
Sbjct: 535 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 594

Query: 318 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 377
            +K    + +    +G  +   ++   AL  +R    +   +   +NN+ +         
Sbjct: 595 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 654

Query: 378 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 437
                   AL L  N+     + ++L +V         +   F  A+  N N A  + NL
Sbjct: 655 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 711

Query: 438 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 486
           AVL  R GH++ A+   + +  L P       N+  +  K+  +Q+  V
Sbjct: 712 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 760


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)

Query: 294 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 352
           +LC I R Y E++    A   + EV + +N  VE +  I S   +  Q ++AL    + L
Sbjct: 507 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 565

Query: 353 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 412
             M   + + +   G C    +++D+ +  F+RA+ +  N   A  +   LGH  V   +
Sbjct: 566 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 622

Query: 413 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 462
            + A  CFR A+  N  H  A+  L ++  ++     A    Q A  + P
Sbjct: 623 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 672



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)

Query: 207 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 265
           K A+++ +    H  Y   W   QIG+ Y+ L  Y +AE+ F    + +   V+     +
Sbjct: 488 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 546

Query: 266 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 325
                L + V    L K   D         C     +        A ++++  ++ D  +
Sbjct: 547 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 606

Query: 326 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 385
             A   +G     +++ + AL  +R  +++   +   +  LG+  +  +++ +    F++
Sbjct: 607 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 666

Query: 386 ALSL 389
           AL +
Sbjct: 667 ALDI 670


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 5/170 (2%)

Query: 294 LLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-L 352
           +LC I R Y E++    A   + EV + +N  VE +  I S   +  Q ++AL    + L
Sbjct: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGME-IYSTTLWHLQKDVALSVLSKDL 559

Query: 353 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 412
             M   + + +   G C    +++D+ +  F+RA+ +  N   A  +   LGH  V   +
Sbjct: 560 TDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL---LGHEFVLTEE 616

Query: 413 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 462
            + A  CFR A+  N  H  A+  L ++  ++     A    Q A  + P
Sbjct: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 33/184 (17%), Positives = 74/184 (40%), Gaps = 2/184 (1%)

Query: 207 KTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLA 265
           K A+++ +    H  Y   W   QIG+ Y+ L  Y +AE+ F    + +   V+     +
Sbjct: 482 KEAINILSHLPSH-HYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS 540

Query: 266 KVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTH 325
                L + V    L K   D         C     +        A ++++  ++ D  +
Sbjct: 541 TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY 600

Query: 326 VEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFER 385
             A   +G     +++ + AL  +R  +++   +   +  LG+  +  +++ +    F++
Sbjct: 601 AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK 660

Query: 386 ALSL 389
           AL +
Sbjct: 661 ALDI 664


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 61/310 (19%), Positives = 114/310 (36%), Gaps = 64/310 (20%)

Query: 231 IGKCYYRLGMYREAEKQFKSALKQQEM-------------VDTFLYLAKVYVSLDQPVTA 277
           +G  ++RLG   EA+K F ++L + +              V T   LA++Y ++ +   A
Sbjct: 457 VGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEA 516

Query: 278 LNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHF 337
             L+K  L + P  V     +  +  +  N   A++++KE L+ +  H +A + IG+ H 
Sbjct: 517 EKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHL 576

Query: 338 YSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQ--------------QYDMTLTSF 383
              +     + + R+L+        ++ L L   + Q                D  L  +
Sbjct: 577 AKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636

Query: 384 ERAL-------------------------------SLAENEEEAADVWYNLGHVAVG--- 409
           ++ L                                + E   + +DVW NL H+ V    
Sbjct: 637 KQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQ 696

Query: 410 -IGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 468
            I    +   C R    + N     Y  LA    + G +++ +  L  A  +AP      
Sbjct: 697 YISAVQMYENCLRKFYKHQNTEVVLY--LARALFKCGKLQECKQTLLKARHVAPSDTVLM 754

Query: 469 FNFATISDKI 478
           FN A +  ++
Sbjct: 755 FNVALVLQRL 764



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 53/259 (20%), Positives = 97/259 (37%), Gaps = 54/259 (20%)

Query: 243 EAEKQFKSALKQQ-EMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG---EVTLLCGI 298
           +A+ QF   L Q    +   L  A +  +      AL  +K+ L   PG   EV L  G+
Sbjct: 147 QADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRL--GM 204

Query: 299 ARIYEEMNNMSSAAEYYKEVLKQDNTHVEAI---ACIGSNHFYSDQPEIALRFYRRLLQM 355
              + ++N +  A   +   L+ ++  V A+   A +  N+  +D  +  ++   R   +
Sbjct: 205 GHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTI 264

Query: 356 GIYNGQLFNNLGLCCFYAQQYD----MTLTSFE----------------RALSLAENEEE 395
              N  + N+L    F+ + Y     + L +F                 R+  + E+ ++
Sbjct: 265 DPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQ 324

Query: 396 AADVWYN---------------LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVL 440
           A   +Y                LG + +  GD   A QCF   L    N+ E    L  L
Sbjct: 325 AFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSL 384

Query: 441 ----------EMRKGHVEQ 449
                     ++ KGH+++
Sbjct: 385 YAASEDQEKRDIAKGHLKK 403



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 366 LGLCC--FYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLA 423
           LG  C  F  + Y   L  +++AL    N    A+V   +GH  V +     A   F  A
Sbjct: 167 LGKACISFNKKDYRGALAYYKKALRT--NPGCPAEVRLGMGHCFVKLNKLEKARLAFSRA 224

Query: 424 LVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 458
           L  N+    A   LAVLE+     +  +  +Q  S
Sbjct: 225 LELNSKCVGALVGLAVLELNNKEADSIKNGVQLLS 259


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 24/206 (11%)

Query: 283 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL------KQDNTHVEAIACIGSNH 336
           Q L   PGE      +A +Y  +   + A + Y+E L      K  +   +    +G   
Sbjct: 785 QELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITK 844

Query: 337 FYSDQPEIALRFYRRLLQM---------GIYNGQLFNNLGLCCFYAQQYDMTLTSFERAL 387
              +  E A+ ++ + L M          +  G+ + NLG C      Y+  +  +E+ L
Sbjct: 845 MNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYL 904

Query: 388 SLAEN---EEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN------NHAEAYNNLA 438
           S+A++    ++ A  +  LG+    +G    A  CF   LV  +      N A+AY  L 
Sbjct: 905 SVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964

Query: 439 VLEMRKGHVEQARALLQTASSLAPHM 464
            L  + G+ EQA + L+   ++A  M
Sbjct: 965 SLHSQLGNYEQAISCLERQLNIARDM 990



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 34/264 (12%)

Query: 231  IGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 290
            +G CY  LG Y EA K ++  L   + ++     AK Y  L     A+   +Q L  F  
Sbjct: 883  LGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEK 942

Query: 291  EVTLLCGI------ARIYEEMNNMSSAAEYYKEVLK-----------QDNTHVEAIACIG 333
             + +   +      A+ Y E+ ++ S    Y++ +              +  +E+ A  G
Sbjct: 943  RLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACG 1002

Query: 334  SNHFYSDQPE--IALRFYRRLLQMG------IYNGQLFNNLGLCCFYAQQYDMTLTSFER 385
                Y    E   AL++++  LQ+          G+ + NLGL       ++  +   E+
Sbjct: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062

Query: 386  ALSLAE--NEEEAADVWY-NLGHVAVGIGDTNLA----HQCFRLA--LVNNNNHAEAYNN 436
             LS+A   N+  A  V Y +LG     + + + A     +  RLA  L    + A+  + 
Sbjct: 1063 HLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHG 1122

Query: 437  LAVLEMRKGHVEQARALLQTASSL 460
            L +     G++E+A+  L  AS+L
Sbjct: 1123 LGLSLWASGNLEEAQHQLYRASAL 1146



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 53/244 (21%), Positives = 96/244 (39%), Gaps = 31/244 (12%)

Query: 231 IGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 290
           +G  +Y LG Y+EA K ++  L   + +   L  AK Y +L     AL  F +  +    
Sbjct: 640 LGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKY 699

Query: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
            ++L   +     +   + +  + +  + K+D          G+  FY  Q  +A +   
Sbjct: 700 LLSLAQSLNNSQAKFRALGNLGDIF--ICKKDIN--------GAIKFYEQQLGLAHQVKD 749

Query: 351 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVA--- 407
           R L+   Y       LG      Q+YD  L    + L + +   +        GH+A   
Sbjct: 750 RRLEASAYAA-----LGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVY 804

Query: 408 VGIGDTNLAHQCFR------LALVNNNNHAEAYNNLAVLEMRK-------GHVEQARALL 454
           + +G   +A +C+         L + +  A+ Y N+ + +M         G+ EQ  A+L
Sbjct: 805 MALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864

Query: 455 QTAS 458
           Q  S
Sbjct: 865 QQLS 868



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 9/95 (9%)

Query: 365 NLGLCCFYAQQYDMTLTSFERALSLA---ENEEEAADVWYNLGHVAVGIGDTNLA----H 417
           NLG   F    Y   LT+    L LA   ++ E A+    +LGHV   IGD   A     
Sbjct: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338

Query: 418 QCFRLALVNNNNHAEA--YNNLAVLEMRKGHVEQA 450
           QC  LA  + +  +EA    N+  + +  G  E A
Sbjct: 339 QCVLLAKQSKDELSEARELGNMGAVYIAMGDFENA 373


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 53/258 (20%), Positives = 112/258 (43%), Gaps = 37/258 (14%)

Query: 241 YREAEKQFKSALKQ-QEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIA 299
           ++EAE+ +++ +K   +  D         V    P  A+  ++Q +   P     +  + 
Sbjct: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549

Query: 300 RIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRR-------- 351
           R+Y  +   S A E+YK  L+  +   E ++ +G+ ++ + + E AL+ Y+         
Sbjct: 550 RLYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQ 608

Query: 352 ------LLQMGIYNGQ------LFNNLG------------LCCFYAQQ--YDMTLTSFER 385
                 L Q+    GQ      + N++             L   Y++Q  +D  L + ++
Sbjct: 609 RELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDK 668

Query: 386 ALSLAENEEEA-ADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRK 444
           AL L   + +  +++++  G+        + A + +R+A+  N + A+A+ N+  ++  K
Sbjct: 669 ALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIK 728

Query: 445 GHVEQARALLQTASSLAP 462
           G    ARA  + A  L P
Sbjct: 729 GKYVSARAYYERALQLVP 746



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 47/225 (20%), Positives = 91/225 (40%), Gaps = 13/225 (5%)

Query: 279 NLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFY 338
           +LF+ G+   P    +    A   ++      A  +Y+  LK    H  A+  +G+    
Sbjct: 362 SLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGT--LT 419

Query: 339 SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAAD 398
            D  E A  +Y+R LQ+   + +   NLG      ++ +  +T  + ++       E AD
Sbjct: 420 RDTAE-AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGP---EFAD 475

Query: 399 VWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 458
            + +L  +         A + ++  + N  + ++ +NN  V  +  G  E+A A  Q A 
Sbjct: 476 AYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAI 535

Query: 459 SLAPHMYEPHFNFATISDKIGD-------LQRSYVAAQKSEAAFP 496
            L+P  +    N   +   +G+        +R+   A K+E   P
Sbjct: 536 KLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP 580



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 37/169 (21%), Positives = 64/169 (37%), Gaps = 5/169 (2%)

Query: 231 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
           +G  YY  G Y EA + ++ A   Q    +  L LA+V   + Q   A  +    + +  
Sbjct: 581 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEET 640

Query: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVL----KQDNTHVEAIACIGSNHFYSDQPEIA 345
           G +     ++ IY +  N   A +   + L    K      E     G+     +  + A
Sbjct: 641 GCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKA 700

Query: 346 LRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE 394
              YR  +Q+     Q + N+G       +Y      +ERAL L  + +
Sbjct: 701 FESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSK 749


>gi|224809432 transmembrane and tetratricopeptide repeat containing
           3 [Homo sapiens]
          Length = 914

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)

Query: 277 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 333
           AL  F Q     P ++     + R Y+ +N    A E Y   K ++ Q     +  A I 
Sbjct: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524

Query: 334 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 381
            NH                + E A + YR+ + M     Q + + G       +      
Sbjct: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584

Query: 382 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441
           ++ +AL L  N    AD+WYNL  V + + + N A + F  AL  N  H  A  N A++ 
Sbjct: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641

Query: 442 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 475
              G V+   +AR  L +  +  P     +FN   ++
Sbjct: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)

Query: 215 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 266
           L   H Q  D    + +G+ Y  L   +EAE+ +  A     +++    Y A+       
Sbjct: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529

Query: 267 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 318
           VY++L   + A          L++Q +   P           +  +MN    A E Y + 
Sbjct: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589

Query: 319 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 378
           L+ D  + +    +   H    +P  AL+ + R L++   +     N  +    + +  +
Sbjct: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649

Query: 379 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 438
              + +R LS    E   A+ ++NLG +A+     N A    + A+    +   A  NLA
Sbjct: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709

Query: 439 VLEMRKGHVEQARALLQ 455
           +L  +     +A  +L+
Sbjct: 710 LLYSQTAKELKALPILE 726


>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
          Length = 1564

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 64/278 (23%), Positives = 118/278 (42%), Gaps = 49/278 (17%)

Query: 238 LGMYREAEKQFKSALKQQE--------MVDTFLYLAKVYV-------SLDQPVTALNLFK 282
           LG Y+EA  Q++  +K++E        + +  L +AK  +       ++D    AL  F 
Sbjct: 645 LGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFT 704

Query: 283 QGLD---------KFPGEV-TLLCGIA--RIYEEMNNMSSAAEYYKEVLKQDNT------ 324
             L          K  G+  T L  +A  ++   +  +    +  K+VLK++        
Sbjct: 705 CALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGR 764

Query: 325 -HVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 383
            +  A+  + +++ + D   + + +YR+   +    G   N+L       +  + +L   
Sbjct: 765 CYGRALKLMSTSNTWCD---LGINYYRQAQHLA-ETGSNMNDL------KELLEKSLHCL 814

Query: 384 ERALSLAENEEEAADVWYNLGHVAV--GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441
           ++A+ L  N       W  LG VA   GIG+  LA  CF  ++ +   +A A+ NL VL 
Sbjct: 815 KKAVRLDSNNHL---YWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLY 871

Query: 442 MRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIG 479
           +   ++EQA    + A SL P         A I++ +G
Sbjct: 872 LTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVG 909



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 19/71 (26%), Positives = 42/71 (59%), Gaps = 1/71 (1%)

Query: 241 YREAEKQFKSALKQQEM-VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIA 299
           Y+EA K  K+ LKQ++   + ++++      L+QP  A + +K+  +  P ++    G+A
Sbjct: 22  YKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLA 81

Query: 300 RIYEEMNNMSS 310
            +YE+ N++++
Sbjct: 82  NLYEKYNHINA 92



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 29/135 (21%), Positives = 60/135 (44%), Gaps = 4/135 (2%)

Query: 205 DVKTALDLAALSTEHSQY--KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEM-VDTF 261
           D++ AL +    T+ +      W W ++ G  Y + G + +A    ++AL+      + +
Sbjct: 543 DMEMALAILTTVTQKASAGTAKWAW-LRRGLYYLKAGQHSQAVADLQAALRADPKDFNCW 601

Query: 262 LYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQ 321
             L + Y+S     TAL  F +  +  P  +  +  +A I + +     A   Y+ ++K+
Sbjct: 602 ESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKK 661

Query: 322 DNTHVEAIACIGSNH 336
              +V A+  +G  H
Sbjct: 662 KEDYVPALKGLGECH 676



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 13/200 (6%)

Query: 268 YVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVE 327
           Y S ++ +  L+      D  PG + L    +  Y    +   AA+  +++L       E
Sbjct: 366 YDSSEEAIRTLDQISDA-DNIPGLLVLK---SLAYRNKGSFDEAAKIMEDLLSSYPDLAE 421

Query: 328 AIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQY---DMT--LTS 382
             A     HF       A + ++R L+      +    LGL  ++  +    D T  LT 
Sbjct: 422 VHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTH 481

Query: 383 FERALSLAENEEEAADVWYNLGHVAVGI-GDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441
           F +A  L   +     V+  LGH    + GD N A  C+R A   ++  AE+      L 
Sbjct: 482 FLKAARL---DTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLS 538

Query: 442 MRKGHVEQARALLQTASSLA 461
           +    +E A A+L T +  A
Sbjct: 539 VELEDMEMALAILTTVTQKA 558



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 15/165 (9%)

Query: 340  DQPEIALRFYRRLL-QMGIYNG--QLFNN-----------LGLCCFYAQQYDMTLTSFER 385
            D   +A+R Y RLL   G Y+   Q F +             L  F    Y  +  ++ER
Sbjct: 1017 DTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYER 1076

Query: 386  ALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKG 445
            ALS+ E+E++ A +   L       G T++A        +      E+   L  L +   
Sbjct: 1077 ALSIVESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQ 1136

Query: 446  HVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQK 490
                ++A L        H  + ++    ++  I  LQ   VA QK
Sbjct: 1137 DATLSKAALNELLKHIKHK-DSNYQRCLLTSAIYALQGRSVAVQK 1180


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 1/172 (0%)

Query: 238 LGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCG 297
           LG   EA      A++ Q     + +   +Y   +   TA   F+Q L+    +   +  
Sbjct: 176 LGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235

Query: 298 IARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGI 357
               +     +  A E +KE LKQ    ++A   +G  +      E A   +++ L +  
Sbjct: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 295

Query: 358 YNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVG 409
            + Q     G+  ++       L +F+R L L E   E       L HVA+G
Sbjct: 296 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQL-EPYNEVCQYMKGLSHVAMG 346



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 1/129 (0%)

Query: 232 GKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 290
           G  Y+    Y  A + F+ +L+  +      LY    +        A+  FK+ L +   
Sbjct: 203 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 262

Query: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
            +     + + Y E+ N  +A E +++ L  +  HV+ +   G   ++    + AL+ ++
Sbjct: 263 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFK 322

Query: 351 RLLQMGIYN 359
           R LQ+  YN
Sbjct: 323 RCLQLEPYN 331



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 35/184 (19%), Positives = 76/184 (41%), Gaps = 11/184 (5%)

Query: 280 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 339
           L+ + +  F   + +L  + RI E +N+++ A +         +         G+ +F S
Sbjct: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHR--------GTLYFIS 209

Query: 340 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 399
           +    A   +++ L++           GL  F+       + SF+ AL   + + +  D 
Sbjct: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEAL---KQKVDFIDA 266

Query: 400 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 459
           + +LG     +G+   A + F+ AL+ N NH +      ++    G +++A    +    
Sbjct: 267 YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ 326

Query: 460 LAPH 463
           L P+
Sbjct: 327 LEPY 330


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 1/172 (0%)

Query: 238 LGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCG 297
           LG   EA      A++ Q     + +   +Y   +   TA   F+Q L+    +   +  
Sbjct: 229 LGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 288

Query: 298 IARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGI 357
               +     +  A E +KE LKQ    ++A   +G  +      E A   +++ L +  
Sbjct: 289 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348

Query: 358 YNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVG 409
            + Q     G+  ++       L +F+R L L E   E       L HVA+G
Sbjct: 349 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQL-EPYNEVCQYMKGLSHVAMG 399



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 1/129 (0%)

Query: 232 GKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPG 290
           G  Y+    Y  A + F+ +L+  +      LY    +        A+  FK+ L +   
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 315

Query: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
            +     + + Y E+ N  +A E +++ L  +  HV+ +   G   ++    + AL+ ++
Sbjct: 316 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFK 375

Query: 351 RLLQMGIYN 359
           R LQ+  YN
Sbjct: 376 RCLQLEPYN 384



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 43/238 (18%), Positives = 95/238 (39%), Gaps = 24/238 (10%)

Query: 239 GMYREAEKQFKSALKQQEMVDTFLY-------------LAKVYVSLDQPVTALNLFKQGL 285
           G+Y EA + F + L+++  + + +Y             +    ++L +    + L     
Sbjct: 157 GLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRP 216

Query: 286 DKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIA 345
           + F     +L  + RI E +N+++ A +         +         G+ +F S+    A
Sbjct: 217 EVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHR--------GTLYFISEDYATA 268

Query: 346 LRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 405
              +++ L++           GL  F+       + SF+ AL   + + +  D + +LG 
Sbjct: 269 HEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEAL---KQKVDFIDAYKSLGQ 325

Query: 406 VAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPH 463
               +G+   A + F+ AL+ N NH +      ++    G +++A    +    L P+
Sbjct: 326 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 383


>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
           sapiens]
          Length = 833

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)

Query: 232 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 290
           G   +  G Y +A + +K AL+        LY +   Y  L++   AL+ F +       
Sbjct: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559

Query: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
              +L  IA IYE M N S A E+  +V+    T  + ++ +G  +        A ++Y 
Sbjct: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619

Query: 351 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 386
              +    N ++   LG      Q ++  +  FERA
Sbjct: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)

Query: 231 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
           IG  Y +L    EA   F K     +   +    +A +Y  ++ P  A+    Q +   P
Sbjct: 533 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592

Query: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
            +  +L  +  +Y+   + S A +YY E  +    ++E I  +G+ +  +   E A++++
Sbjct: 593 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652

Query: 350 RR 351
            R
Sbjct: 653 ER 654



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)

Query: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 350
           ++L  +A  Y      + A   Y+ ++K        I  +   + Y  Q     A++FYR
Sbjct: 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266

Query: 351 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 405
             L Q+   N Q+      N+G+    A QY   + S+E  +S+A N +      YNL  
Sbjct: 267 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 322

Query: 406 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 448
               IGD     + F+  +                  + N   EA  N  + +M +    
Sbjct: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382

Query: 449 QARALLQTASSLAPHMYEPHF 469
            A   + T++ L   + E  F
Sbjct: 383 MAEKYIMTSAKLIAPVIETSF 403



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)

Query: 302 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 360
           Y    + + A E  K + K+D+    A A   S  +Y  +       Y  + +    YN 
Sbjct: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
               N G   F    Y+     ++ AL    N+    +  YN+G     +   + A  CF
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 550

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
                   N AE    +A +     +  QA   L    S+ P   +       + D+ GD
Sbjct: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610

Query: 481 LQRSYVAAQKSEAAFPDHVD 500
             +++    +S   FP +++
Sbjct: 611 KSQAFQYYYESYRYFPCNIE 630


>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)

Query: 232 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 290
           G   +  G Y +A + +K AL+        LY +   Y  L++   AL+ F +       
Sbjct: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550

Query: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
              +L  IA IYE M N S A E+  +V+    T  + ++ +G  +        A ++Y 
Sbjct: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610

Query: 351 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 386
              +    N ++   LG      Q ++  +  FERA
Sbjct: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)

Query: 231 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
           IG  Y +L    EA   F K     +   +    +A +Y  ++ P  A+    Q +   P
Sbjct: 524 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583

Query: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
            +  +L  +  +Y+   + S A +YY E  +    ++E I  +G+ +  +   E A++++
Sbjct: 584 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643

Query: 350 RR 351
            R
Sbjct: 644 ER 645



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)

Query: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 350
           ++L  +A  Y      + A   Y+ ++K        I  +   + Y  Q     A++FYR
Sbjct: 198 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257

Query: 351 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 405
             L Q+   N Q+      N+G+    A QY   + S+E  +S+A N +      YNL  
Sbjct: 258 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 313

Query: 406 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 448
               IGD     + F+  +                  + N   EA  N  + +M +    
Sbjct: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373

Query: 449 QARALLQTASSLAPHMYEPHF 469
            A   + T++ L   + E  F
Sbjct: 374 MAEKYIMTSAKLIAPVIETSF 394



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)

Query: 302 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 360
           Y    + + A E  K + K+D+    A A   S  +Y  +       Y  + +    YN 
Sbjct: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
               N G   F    Y+     ++ AL    N+    +  YN+G     +   + A  CF
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 541

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
                   N AE    +A +     +  QA   L    S+ P   +       + D+ GD
Sbjct: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601

Query: 481 LQRSYVAAQKSEAAFPDHVD 500
             +++    +S   FP +++
Sbjct: 602 KSQAFQYYYESYRYFPCNIE 621


>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
           chromosome [Homo sapiens]
          Length = 1401

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 260 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 319
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 286 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 345

Query: 320 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 346 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 375



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 214 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 272
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 276 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 332

Query: 273 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 315
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 333 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 375


>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
           sapiens]
          Length = 1347

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 260 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 319
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342

Query: 320 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 214 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 272
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329

Query: 273 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 315
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 319
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81

Query: 320 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 372
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139

Query: 373 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 428
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199

Query: 429 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 477
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259

Query: 478 IGDLQRSYVAAQKSEAAFPD 497
                 +    QKS  A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279


>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
           sapiens]
          Length = 1079

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 260 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 319
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342

Query: 320 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 214 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 272
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329

Query: 273 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 315
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 319
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81

Query: 320 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 372
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139

Query: 373 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 428
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199

Query: 429 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 477
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259

Query: 478 IGDLQRSYVAAQKSEAAFPD 497
                 +    QKS  A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279


>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
           sapiens]
          Length = 1240

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 260 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 319
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342

Query: 320 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 214 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 272
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329

Query: 273 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 315
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 319
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81

Query: 320 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 372
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139

Query: 373 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 428
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199

Query: 429 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 477
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259

Query: 478 IGDLQRSYVAAQKSEAAFPD 497
                 +    QKS  A P+
Sbjct: 260 ATKESYAIQYLQKSLEADPN 279


>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
          Length = 843

 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/111 (22%), Positives = 52/111 (46%)

Query: 257 MVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYK 316
           +   +L+ A+VY+ + +P  A    ++  + FP    +L    +I E   +M  A  +Y+
Sbjct: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE 754

Query: 317 EVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLG 367
           E L    THV+++  +        +  +A +  R  +Q+     +++N LG
Sbjct: 755 EALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 52/268 (19%), Positives = 99/268 (36%), Gaps = 41/268 (15%)

Query: 245 EKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGEV---TLLCGIAR 300
           ++  K     +  V + LY L K+Y        AL+++K+ + K P +    +L   +  
Sbjct: 592 DENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGE 651

Query: 301 IYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 360
            Y  ++ +  A  +Y E L+    H+ A    G     + +   A + + + +++    G
Sbjct: 652 AYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKG 711

Query: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
             + + G    +  +    + + E A   AE +    DV +N  H+              
Sbjct: 712 NCYMHYGQ---FLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHM-------------- 754

Query: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
            L   + N  AE Y +LA                   + L P+      N   I    G 
Sbjct: 755 -LRQASLNEAAEKYYDLA-------------------ARLRPNYPAALMNLGAILHLNGR 794

Query: 481 LQRSYVAAQKSEAAFPDHVDTQHLIKQL 508
           LQ++     ++    PD V TQ  +++L
Sbjct: 795 LQKAEANYLRALQLKPDDVITQSNLRKL 822



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 29/124 (23%), Positives = 56/124 (45%), Gaps = 4/124 (3%)

Query: 363 FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRL 422
           + NLG       +     +++  AL    N    AD+ YNLG +         A   ++L
Sbjct: 496 WGNLGNVLKSQSKISEAESAYRNALYYRSN---MADMLYNLGLLLQENSRFAEALHYYKL 552

Query: 423 ALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLA-PHMYEPHFNFATISDKIGDL 481
           A+ +    A AY N  ++ M +G  E+AR      S +   ++ +PH + ++++  + +L
Sbjct: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612

Query: 482 QRSY 485
            + Y
Sbjct: 613 GKLY 616



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 20/78 (25%), Positives = 30/78 (38%)

Query: 397 ADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQT 456
           A  W NLG+V       + A   +R AL   +N A+   NL +L        +A    + 
Sbjct: 493 AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKL 552

Query: 457 ASSLAPHMYEPHFNFATI 474
           A    P +   + N   I
Sbjct: 553 AIGSRPTLASAYLNTGII 570


>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
          Length = 292

 Score = 38.5 bits (88), Expect = 0.015
 Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 7/108 (6%)

Query: 232 GKCYYRLGMYREAEKQFKSALK------QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGL 285
           G   ++ G Y EAE  +  AL+      Q+E    F   A   +  D+   A+N   + +
Sbjct: 123 GNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAI 182

Query: 286 DKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQD-NTHVEAIACI 332
              P  +  +   A +YE+ + +  A E YK +L++D + H    AC+
Sbjct: 183 QLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACM 230


>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
          Length = 1113

 Score = 37.0 bits (84), Expect = 0.043
 Identities = 49/200 (24%), Positives = 78/200 (39%), Gaps = 36/200 (18%)

Query: 28   TQMLEKS-PYDQEPDPELPVHQAAWILKARALTEMVYIDEIDVDQEGIAEMMLDENAIAQ 86
            TQ LE S  Y++  + E    +    ++     E V+ ++   D +G   + +D+    +
Sbjct: 835  TQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTE 894

Query: 87   VPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPST----QSGRPGTMEQAIRTP 142
             P P  ++  P   + G PSQ              FLR ST    ++  PG        P
Sbjct: 895  TPAPSPTVVRPKDRRVGTPSQG------------PFLRGSTIIRSKTFSPG--------P 934

Query: 143  RTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKAL-FEYIFH 201
            ++ Y  R   S S         S   S   PF+  S    +   ++P   K+L  E +  
Sbjct: 935  QSQYVCRLNRSDSD--------SSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRSERLIR 986

Query: 202  HENDVKTALDLAALSTEHSQ 221
               D++  LDL A  T HSQ
Sbjct: 987  TSLDLE--LDLQATRTWHSQ 1004


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score = 36.6 bits (83), Expect = 0.056
 Identities = 69/278 (24%), Positives = 109/278 (39%), Gaps = 62/278 (22%)

Query: 235  YYRLGMYREAE----KQFK---SALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDK 287
            Y +   Y +AE    K FK    A+K++  +  F  L +  + L++    L L K     
Sbjct: 1037 YQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEE----LTLGKDT--- 1089

Query: 288  FPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALR 347
             P     L  +  +Y   NN+ +A ++ K  L+           +G +H     P+ A  
Sbjct: 1090 -PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER------VLGPDH-----PDCA-- 1135

Query: 348  FYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAEN--EEEAADVWYNLGH 405
                         Q  NNL   C   +QYD     +ERAL +       +   + Y + H
Sbjct: 1136 -------------QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKH 1182

Query: 406  VAV---GIGDTNLAHQCFRLAL--------VNNNNHAEAYNNLAVL-EMRKGHVE----Q 449
            +A+    +G  + A   + LA+          + + A A  NLAVL    K HVE     
Sbjct: 1183 LAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLY 1242

Query: 450  ARALLQTASSLA---PHMYEPHFNFATISDKIGDLQRS 484
             RAL     SL    P + E   N A +S + GD +++
Sbjct: 1243 ERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKA 1280


>gi|118402596 cell division cycle protein 23 [Homo sapiens]
          Length = 597

 Score = 36.6 bits (83), Expect = 0.056
 Identities = 35/163 (21%), Positives = 64/163 (39%), Gaps = 3/163 (1%)

Query: 258 VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKE 317
           V+T   +   Y    Q   A   F++ L   P  +     +   Y EM N S+A + Y+ 
Sbjct: 331 VETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRH 390

Query: 318 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 377
            ++ +     A   +G  +     P   L +YRR  Q+   + ++   LG C     Q  
Sbjct: 391 AIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLV 450

Query: 378 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
                + RA ++ + E+ A      L  +   + ++  A QC+
Sbjct: 451 EAKKCYWRAYAVGDVEKMAL---VKLAKLHEQLTESEQAAQCY 490


>gi|40548372 tetratricopeptide repeat domain 15 [Homo sapiens]
          Length = 735

 Score = 35.8 bits (81), Expect = 0.096
 Identities = 33/147 (22%), Positives = 61/147 (41%), Gaps = 7/147 (4%)

Query: 264 LAKVYVSLDQPVTALNLFKQGLDKFPG-EVTLLCGIARIYEEMNNMSSAAEYYKEV---- 318
           +A   + +   V A+  +   +  +P  E  LL GI RI  ++ ++ +A +Y+++V    
Sbjct: 551 MANCLLLMKDYVLAVEAYHSVIKYYPEQEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVT 610

Query: 319 LKQDNTHVEAIACIGSNHFYSDQPEIAL--RFYRRLLQMGIYNGQLFNNLGLCCFYAQQY 376
            K D    + +  + S   +  Q   A   RF+  +L+M   N    NN  +C  Y  + 
Sbjct: 611 QKLDGLQGKIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKL 670

Query: 377 DMTLTSFERALSLAENEEEAADVWYNL 403
             +L   E  +           V +NL
Sbjct: 671 KDSLRQLEAMVQQDPRHYLHESVLFNL 697



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 6/82 (7%)

Query: 241 YREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIAR 300
           Y E E Q  S + +  +    +  A+ Y    + VT      Q LD   G++ +L   A 
Sbjct: 575 YPEQEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVT------QKLDGLQGKIMVLMNSAF 628

Query: 301 IYEEMNNMSSAAEYYKEVLKQD 322
           ++   NN + A  ++ E+L+ D
Sbjct: 629 LHLGQNNFAEAHRFFTEILRMD 650


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,555,622
Number of Sequences: 37866
Number of extensions: 813931
Number of successful extensions: 2665
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 2421
Number of HSP's gapped (non-prelim): 202
length of query: 515
length of database: 18,247,518
effective HSP length: 107
effective length of query: 408
effective length of database: 14,195,856
effective search space: 5791909248
effective search space used: 5791909248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.