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Search of human proteins with 51972208
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
(388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens] 744 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 75 8e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 75 8e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 75 8e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 75 8e-14
gi|46852390 coiled-coil domain containing 6 [Homo sapiens] 72 7e-13
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 72 1e-12
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 71 1e-12
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 70 2e-12
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 70 2e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 70 2e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 70 2e-12
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 69 6e-12
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 69 6e-12
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 69 6e-12
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 68 1e-11
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 68 1e-11
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 68 1e-11
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 68 1e-11
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 68 1e-11
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 68 1e-11
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 68 1e-11
gi|38044112 restin isoform b [Homo sapiens] 67 3e-11
gi|4506751 restin isoform a [Homo sapiens] 67 3e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 67 4e-11
gi|148746195 trichohyalin [Homo sapiens] 66 6e-11
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 66 6e-11
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 65 1e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 1e-10
gi|50083279 centrosome protein 4 [Homo sapiens] 65 1e-10
>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
Length = 388
Score = 744 bits (1922), Expect = 0.0
Identities = 388/388 (100%), Positives = 388/388 (100%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL
Sbjct: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF
Sbjct: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT
Sbjct: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
Query: 181 RYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQT 240
RYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQT
Sbjct: 181 RYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQT 240
Query: 241 QLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300
QLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK
Sbjct: 241 QLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300
Query: 301 GSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVSKPTTFPTSDKPKRVRSGVPILPQP 360
GSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVSKPTTFPTSDKPKRVRSGVPILPQP
Sbjct: 301 GSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVSKPTTFPTSDKPKRVRSGVPILPQP 360
Query: 361 HPPRGGASSANETRQRLAAILRRRRSQQ 388
HPPRGGASSANETRQRLAAILRRRRSQQ
Sbjct: 361 HPPRGGASSANETRQRLAAILRRRRSQQ 388
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 75.5 bits (184), Expect = 8e-14
Identities = 77/288 (26%), Positives = 136/288 (47%), Gaps = 28/288 (9%)
Query: 21 QEELTVKEKQEEDIKRRINLAENEL--------EIT--KTLLN---QTREEVLTLKNERE 67
+EE+ KE + + K R AENEL ++T K LL Q E+ E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 68 LMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
+ L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E + +
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEEAARQK 968
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESN 187
L +EK + K KK ++E+ ++ L +E L+E++ T EE
Sbjct: 969 LQLEKVTAE---AKIKKLEDEIL-----VMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1019
Query: 188 SKEKEIENLKN----LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K K + LKN +++E E RLKKE S + + RK SD +++ Q Q+
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
E Q ++ LQ + R +E + AL + RE +S L+ L
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Score = 65.5 bits (158), Expect = 8e-11
Identities = 74/314 (23%), Positives = 143/314 (45%), Gaps = 37/314 (11%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
++ KED L ++ + + EL E++ + NL + +L Q E+
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL--------QAETELYAE 905
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
E + L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEE 963
Query: 123 ETKLQLDIEK-------EKHQDVI-------QKYKKEQEELQMKISDLITGATRDLRQ-- 166
+ +L +EK +K +D I K KE++ L+ +ISDL T + +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 167 EVTTLKEKLHKS-----HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENL 221
+T LK K H+S R +E S++ E+E LK + S ++I + L
Sbjct: 1024 NLTKLKNK-HESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 222 RKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE----ERFELTEALSQA 277
+ ++ +K +EL+ + I Q N + ++ L+ + E ER +A Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 278 REQLLELSKLRGSL 291
R+ EL L+ L
Sbjct: 1142 RDLGEELEALKTEL 1155
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/284 (21%), Positives = 126/284 (44%), Gaps = 22/284 (7%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ + + E+ ++ +++ +NE+E +LN+ + + L + + Q + E
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 80 LQETLRQKLLSDDNWKE-KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD- 137
LQE RQKL ++ + E +++ +E ++ +QL K+K QD
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 138 --VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
++ ++ ++ Q +I +L +E +KL K+ R +E + +++N
Sbjct: 1384 ASTVEALEEGKKRFQKEIENL-----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 196 LKNLVAEFESRLKK--------EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN 247
+ LV+ E + +K + S+ E R E E + E K + LA+ +E+
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA--LEEAL 1496
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
+++EE L+ T + E +L + + + EL K + +L
Sbjct: 1497 EAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Score = 54.3 bits (129), Expect = 2e-07
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 44/297 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEIT-------KTLLNQT 55
++E E + Q+ + + EKQ+ D+ + + ELE T + L +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFE 114
+EV LK + SH+ ++++++ Q + E++ +L + +RA+ ++
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV-------EELTEQLEQFKRAKANLDKN 1225
Query: 115 EQALLFKEETKL--QLDIEKEKHQDVIQKYKK---EQEELQMKISDLITGATRDLRQEVT 169
+Q L KE L +L + + Q+V K KK + +ELQ K SD R E
Sbjct: 1226 KQTLE-KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAE-- 1277
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
L +K+HK + E+E++ ++ E E + K S+S L+ E
Sbjct: 1278 -LNDKVHKL-----------QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+E ++ + T+L Q +EE LQ+ + E E + L +S QL + K
Sbjct: 1326 EETRQKLNVSTKL----RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Score = 50.8 bits (120), Expect = 2e-06
Identities = 58/316 (18%), Positives = 139/316 (43%), Gaps = 25/316 (7%)
Query: 3 LKEKEDSLMTCQQIY---KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV 59
+K +E+++ +++ K Q EL ++I E + + + L Q +E++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKE------KIEAELAKERA--QHLV 111
+ R+ + ++ E+L +L + D + ++E EL +E+ + +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 112 EFEEQALLFKEETKLQLDIEK---EKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEV 168
+ +A E+ +L E+ +K++ Q+ +++ +EL+ K+ ++ + +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 169 TTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
L+ K+ + + +E+ K+ ++LK + + +LK+ + E+ RK EQ
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLK----QKDKKLKEILLQ----VEDERKMAEQY 1868
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFL---QETVRRECEERFELTEALSQAREQLLELS 285
++ ++ QL Q +++EE+ + + ++RE +E E EA+ + L
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 286 KLRGSLPFSPCSLSKG 301
+ F P S G
Sbjct: 1929 RRGNETSFVPSRRSGG 1944
Score = 45.4 bits (106), Expect = 9e-05
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 55/360 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+EKE ++ + +AL+E L KE ELE T +L E++++ K
Sbjct: 1479 REKETKALS---LARALEEALEAKE---------------ELERTNKMLKAEMEDLVSSK 1520
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL-AKERAQHLVEFEEQALLFKE 122
++ + + +E+ + L ++ E++E EL A E A+ +E QAL K
Sbjct: 1521 DD----VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL--KG 1574
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ + L E++++ ++ +++ E + ++ D R R K+KL
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDL 1629
Query: 183 TEESNS----KEKEIENLKNLVA---EFESRLKKEIDSNDSV----------SENLRKEM 225
+++S +E+ I+ L+ L A +F+ L+ S D + +++L ++
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 226 EQKSDEL-------KRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
Q ++L K+ L + +L E+ S LQ+ RR +L E L + +
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 279 EQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGER-SLARLNSEKGIQIPNLRGVSK 337
+ +S LS T + A N R L R N E ++ + G K
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Score = 38.9 bits (89), Expect = 0.008
Identities = 40/188 (21%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+EE + E +K ++ QK + E +EL+ K S L +E L+E+L
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHS--------QLTEEKNLLQEQLQAETE 901
Query: 181 RYTEESNSKEK---EIENLKNLVAEFESRLKKEIDSNDSVSE----------NLRKEMEQ 227
Y E + + + + L+ ++ E E+RL++E D + +L +++E+
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE------TVRRECEERF-ELTEALSQAREQ 280
+ +++ L + + + ++E + + R+ EER +LT L++ E+
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 281 LLELSKLR 288
L+KL+
Sbjct: 1022 AKNLTKLK 1029
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 75.5 bits (184), Expect = 8e-14
Identities = 77/288 (26%), Positives = 136/288 (47%), Gaps = 28/288 (9%)
Query: 21 QEELTVKEKQEEDIKRRINLAENEL--------EIT--KTLLN---QTREEVLTLKNERE 67
+EE+ KE + + K R AENEL ++T K LL Q E+ E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 68 LMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
+ L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E + +
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEEAARQK 975
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESN 187
L +EK + K KK ++E+ ++ L +E L+E++ T EE
Sbjct: 976 LQLEKVTAE---AKIKKLEDEIL-----VMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1026
Query: 188 SKEKEIENLKN----LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K K + LKN +++E E RLKKE S + + RK SD +++ Q Q+
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
E Q ++ LQ + R +E + AL + RE +S L+ L
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Score = 65.5 bits (158), Expect = 8e-11
Identities = 74/314 (23%), Positives = 143/314 (45%), Gaps = 37/314 (11%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
++ KED L ++ + + EL E++ + NL + +L Q E+
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL--------QAETELYAE 912
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
E + L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEE 970
Query: 123 ETKLQLDIEK-------EKHQDVI-------QKYKKEQEELQMKISDLITGATRDLRQ-- 166
+ +L +EK +K +D I K KE++ L+ +ISDL T + +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 167 EVTTLKEKLHKS-----HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENL 221
+T LK K H+S R +E S++ E+E LK + S ++I + L
Sbjct: 1031 NLTKLKNK-HESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 222 RKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE----ERFELTEALSQA 277
+ ++ +K +EL+ + I Q N + ++ L+ + E ER +A Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 278 REQLLELSKLRGSL 291
R+ EL L+ L
Sbjct: 1149 RDLGEELEALKTEL 1162
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/284 (21%), Positives = 126/284 (44%), Gaps = 22/284 (7%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ + + E+ ++ +++ +NE+E +LN+ + + L + + Q + E
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 80 LQETLRQKLLSDDNWKE-KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD- 137
LQE RQKL ++ + E +++ +E ++ +QL K+K QD
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 138 --VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
++ ++ ++ Q +I +L +E +KL K+ R +E + +++N
Sbjct: 1391 ASTVEALEEGKKRFQKEIENL-----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 196 LKNLVAEFESRLKK--------EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN 247
+ LV+ E + +K + S+ E R E E + E K + LA+ +E+
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA--LEEAL 1503
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
+++EE L+ T + E +L + + + EL K + +L
Sbjct: 1504 EAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Score = 54.3 bits (129), Expect = 2e-07
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 44/297 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEIT-------KTLLNQT 55
++E E + Q+ + + EKQ+ D+ + + ELE T + L +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFE 114
+EV LK + SH+ ++++++ Q + E++ +L + +RA+ ++
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV-------EELTEQLEQFKRAKANLDKN 1232
Query: 115 EQALLFKEETKL--QLDIEKEKHQDVIQKYKK---EQEELQMKISDLITGATRDLRQEVT 169
+Q L KE L +L + + Q+V K KK + +ELQ K SD R E
Sbjct: 1233 KQTLE-KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAE-- 1284
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
L +K+HK + E+E++ ++ E E + K S+S L+ E
Sbjct: 1285 -LNDKVHKL-----------QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+E ++ + T+L Q +EE LQ+ + E E + L +S QL + K
Sbjct: 1333 EETRQKLNVSTKL----RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Score = 50.8 bits (120), Expect = 2e-06
Identities = 58/316 (18%), Positives = 139/316 (43%), Gaps = 25/316 (7%)
Query: 3 LKEKEDSLMTCQQIY---KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV 59
+K +E+++ +++ K Q EL ++I E + + + L Q +E++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKE------KIEAELAKERA--QHLV 111
+ R+ + ++ E+L +L + D + ++E EL +E+ + +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 112 EFEEQALLFKEETKLQLDIEK---EKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEV 168
+ +A E+ +L E+ +K++ Q+ +++ +EL+ K+ ++ + +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 169 TTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
L+ K+ + + +E+ K+ ++LK + + +LK+ + E+ RK EQ
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLK----QKDKKLKEILLQ----VEDERKMAEQY 1875
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFL---QETVRRECEERFELTEALSQAREQLLELS 285
++ ++ QL Q +++EE+ + + ++RE +E E EA+ + L
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 286 KLRGSLPFSPCSLSKG 301
+ F P S G
Sbjct: 1936 RRGNETSFVPSRRSGG 1951
Score = 45.4 bits (106), Expect = 9e-05
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 55/360 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+EKE ++ + +AL+E L KE ELE T +L E++++ K
Sbjct: 1486 REKETKALS---LARALEEALEAKE---------------ELERTNKMLKAEMEDLVSSK 1527
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL-AKERAQHLVEFEEQALLFKE 122
++ + + +E+ + L ++ E++E EL A E A+ +E QAL K
Sbjct: 1528 DD----VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL--KG 1581
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ + L E++++ ++ +++ E + ++ D R R K+KL
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDL 1636
Query: 183 TEESNS----KEKEIENLKNLVA---EFESRLKKEIDSNDSV----------SENLRKEM 225
+++S +E+ I+ L+ L A +F+ L+ S D + +++L ++
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 226 EQKSDEL-------KRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
Q ++L K+ L + +L E+ S LQ+ RR +L E L + +
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 279 EQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGER-SLARLNSEKGIQIPNLRGVSK 337
+ +S LS T + A N R L R N E ++ + G K
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Score = 38.9 bits (89), Expect = 0.008
Identities = 40/188 (21%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+EE + E +K ++ QK + E +EL+ K S L +E L+E+L
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHS--------QLTEEKNLLQEQLQAETE 908
Query: 181 RYTEESNSKEK---EIENLKNLVAEFESRLKKEIDSNDSVSE----------NLRKEMEQ 227
Y E + + + + L+ ++ E E+RL++E D + +L +++E+
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE------TVRRECEERF-ELTEALSQAREQ 280
+ +++ L + + + ++E + + R+ EER +LT L++ E+
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 281 LLELSKLR 288
L+KL+
Sbjct: 1029 AKNLTKLK 1036
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 75.5 bits (184), Expect = 8e-14
Identities = 77/288 (26%), Positives = 136/288 (47%), Gaps = 28/288 (9%)
Query: 21 QEELTVKEKQEEDIKRRINLAENEL--------EIT--KTLLN---QTREEVLTLKNERE 67
+EE+ KE + + K R AENEL ++T K LL Q E+ E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 68 LMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
+ L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E + +
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEEAARQK 975
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESN 187
L +EK + K KK ++E+ ++ L +E L+E++ T EE
Sbjct: 976 LQLEKVTAE---AKIKKLEDEIL-----VMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1026
Query: 188 SKEKEIENLKN----LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K K + LKN +++E E RLKKE S + + RK SD +++ Q Q+
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
E Q ++ LQ + R +E + AL + RE +S L+ L
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Score = 65.5 bits (158), Expect = 8e-11
Identities = 74/314 (23%), Positives = 143/314 (45%), Gaps = 37/314 (11%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
++ KED L ++ + + EL E++ + NL + +L Q E+
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL--------QAETELYAE 912
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
E + L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEE 970
Query: 123 ETKLQLDIEK-------EKHQDVI-------QKYKKEQEELQMKISDLITGATRDLRQ-- 166
+ +L +EK +K +D I K KE++ L+ +ISDL T + +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 167 EVTTLKEKLHKS-----HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENL 221
+T LK K H+S R +E S++ E+E LK + S ++I + L
Sbjct: 1031 NLTKLKNK-HESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 222 RKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE----ERFELTEALSQA 277
+ ++ +K +EL+ + I Q N + ++ L+ + E ER +A Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 278 REQLLELSKLRGSL 291
R+ EL L+ L
Sbjct: 1149 RDLGEELEALKTEL 1162
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/284 (21%), Positives = 126/284 (44%), Gaps = 22/284 (7%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ + + E+ ++ +++ +NE+E +LN+ + + L + + Q + E
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 80 LQETLRQKLLSDDNWKE-KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD- 137
LQE RQKL ++ + E +++ +E ++ +QL K+K QD
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 138 --VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
++ ++ ++ Q +I +L +E +KL K+ R +E + +++N
Sbjct: 1391 ASTVEALEEGKKRFQKEIENL-----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 196 LKNLVAEFESRLKK--------EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN 247
+ LV+ E + +K + S+ E R E E + E K + LA+ +E+
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA--LEEAL 1503
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
+++EE L+ T + E +L + + + EL K + +L
Sbjct: 1504 EAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Score = 54.3 bits (129), Expect = 2e-07
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 44/297 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEIT-------KTLLNQT 55
++E E + Q+ + + EKQ+ D+ + + ELE T + L +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFE 114
+EV LK + SH+ ++++++ Q + E++ +L + +RA+ ++
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV-------EELTEQLEQFKRAKANLDKN 1232
Query: 115 EQALLFKEETKL--QLDIEKEKHQDVIQKYKK---EQEELQMKISDLITGATRDLRQEVT 169
+Q L KE L +L + + Q+V K KK + +ELQ K SD R E
Sbjct: 1233 KQTLE-KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAE-- 1284
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
L +K+HK + E+E++ ++ E E + K S+S L+ E
Sbjct: 1285 -LNDKVHKL-----------QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+E ++ + T+L Q +EE LQ+ + E E + L +S QL + K
Sbjct: 1333 EETRQKLNVSTKL----RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/307 (19%), Positives = 140/307 (45%), Gaps = 27/307 (8%)
Query: 3 LKEKEDSLMTCQQIY---KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV 59
+K +E+++ +++ K Q EL ++I E + + + L Q +E++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKE------KIEAELAKERA--QHLV 111
+ R+ + ++ E+L +L + D + ++E EL +E+ + +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 112 EFEEQALLFKEETKLQLDIEK---EKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEV 168
+ +A E+ +L E+ +K++ Q+ +++ +EL+ K+ ++ + +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 169 TTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
L+ K+ + + +E+ K+ ++LK + + +LK+ + E+ RK EQ
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLK----QKDKKLKEILLQ----VEDERKMAEQY 1875
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFL---QETVRRECEERFELTEALSQAREQLLELS 285
++ ++ QL Q +++EE+ + + ++RE +E E EA+ RE S
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM--GREVNALKS 1933
Query: 286 KLRGSLP 292
KLRG P
Sbjct: 1934 KLRGPPP 1940
Score = 45.4 bits (106), Expect = 9e-05
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 55/360 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+EKE ++ + +AL+E L KE ELE T +L E++++ K
Sbjct: 1486 REKETKALS---LARALEEALEAKE---------------ELERTNKMLKAEMEDLVSSK 1527
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL-AKERAQHLVEFEEQALLFKE 122
++ + + +E+ + L ++ E++E EL A E A+ +E QAL K
Sbjct: 1528 DD----VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL--KG 1581
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ + L E++++ ++ +++ E + ++ D R R K+KL
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDL 1636
Query: 183 TEESNS----KEKEIENLKNLVA---EFESRLKKEIDSNDSV----------SENLRKEM 225
+++S +E+ I+ L+ L A +F+ L+ S D + +++L ++
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 226 EQKSDEL-------KRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
Q ++L K+ L + +L E+ S LQ+ RR +L E L + +
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 279 EQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGER-SLARLNSEKGIQIPNLRGVSK 337
+ +S LS T + A N R L R N E ++ + G K
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Score = 38.9 bits (89), Expect = 0.008
Identities = 40/188 (21%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+EE + E +K ++ QK + E +EL+ K S L +E L+E+L
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHS--------QLTEEKNLLQEQLQAETE 908
Query: 181 RYTEESNSKEK---EIENLKNLVAEFESRLKKEIDSNDSVSE----------NLRKEMEQ 227
Y E + + + + L+ ++ E E+RL++E D + +L +++E+
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE------TVRRECEERF-ELTEALSQAREQ 280
+ +++ L + + + ++E + + R+ EER +LT L++ E+
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 281 LLELSKLR 288
L+KL+
Sbjct: 1029 AKNLTKLK 1036
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 75.5 bits (184), Expect = 8e-14
Identities = 77/288 (26%), Positives = 136/288 (47%), Gaps = 28/288 (9%)
Query: 21 QEELTVKEKQEEDIKRRINLAENEL--------EIT--KTLLN---QTREEVLTLKNERE 67
+EE+ KE + + K R AENEL ++T K LL Q E+ E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 68 LMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
+ L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E + +
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEEAARQK 968
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESN 187
L +EK + K KK ++E+ ++ L +E L+E++ T EE
Sbjct: 969 LQLEKVTAE---AKIKKLEDEIL-----VMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1019
Query: 188 SKEKEIENLKN----LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K K + LKN +++E E RLKKE S + + RK SD +++ Q Q+
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
E Q ++ LQ + R +E + AL + RE +S L+ L
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Score = 65.5 bits (158), Expect = 8e-11
Identities = 74/314 (23%), Positives = 143/314 (45%), Gaps = 37/314 (11%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
++ KED L ++ + + EL E++ + NL + +L Q E+
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL--------QAETELYAE 905
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
E + L + ++ +E++ + +L +++ ++++AE K+ AQ +++ EEQ L +E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQ-LEEEE 963
Query: 123 ETKLQLDIEK-------EKHQDVI-------QKYKKEQEELQMKISDLITGATRDLRQ-- 166
+ +L +EK +K +D I K KE++ L+ +ISDL T + +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 167 EVTTLKEKLHKS-----HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENL 221
+T LK K H+S R +E S++ E+E LK + S ++I + L
Sbjct: 1024 NLTKLKNK-HESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 222 RKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE----ERFELTEALSQA 277
+ ++ +K +EL+ + I Q N + ++ L+ + E ER +A Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 278 REQLLELSKLRGSL 291
R+ EL L+ L
Sbjct: 1142 RDLGEELEALKTEL 1155
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/284 (21%), Positives = 126/284 (44%), Gaps = 22/284 (7%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ + + E+ ++ +++ +NE+E +LN+ + + L + + Q + E
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 80 LQETLRQKLLSDDNWKE-KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD- 137
LQE RQKL ++ + E +++ +E ++ +QL K+K QD
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 138 --VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
++ ++ ++ Q +I +L +E +KL K+ R +E + +++N
Sbjct: 1384 ASTVEALEEGKKRFQKEIENL-----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 196 LKNLVAEFESRLKK--------EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN 247
+ LV+ E + +K + S+ E R E E + E K + LA+ +E+
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA--LEEAL 1496
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
+++EE L+ T + E +L + + + EL K + +L
Sbjct: 1497 EAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Score = 54.3 bits (129), Expect = 2e-07
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 44/297 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEIT-------KTLLNQT 55
++E E + Q+ + + EKQ+ D+ + + ELE T + L +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFE 114
+EV LK + SH+ ++++++ Q + E++ +L + +RA+ ++
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV-------EELTEQLEQFKRAKANLDKN 1225
Query: 115 EQALLFKEETKL--QLDIEKEKHQDVIQKYKK---EQEELQMKISDLITGATRDLRQEVT 169
+Q L KE L +L + + Q+V K KK + +ELQ K SD R E
Sbjct: 1226 KQTLE-KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAE-- 1277
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
L +K+HK + E+E++ ++ E E + K S+S L+ E
Sbjct: 1278 -LNDKVHKL-----------QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+E ++ + T+L Q +EE LQ+ + E E + L +S QL + K
Sbjct: 1326 EETRQKLNVSTKL----RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/307 (19%), Positives = 140/307 (45%), Gaps = 27/307 (8%)
Query: 3 LKEKEDSLMTCQQIY---KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV 59
+K +E+++ +++ K Q EL ++I E + + + L Q +E++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKE------KIEAELAKERA--QHLV 111
+ R+ + ++ E+L +L + D + ++E EL +E+ + +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 112 EFEEQALLFKEETKLQLDIEK---EKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEV 168
+ +A E+ +L E+ +K++ Q+ +++ +EL+ K+ ++ + +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 169 TTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
L+ K+ + + +E+ K+ ++LK + + +LK+ + E+ RK EQ
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLK----QKDKKLKEILLQ----VEDERKMAEQY 1868
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFL---QETVRRECEERFELTEALSQAREQLLELS 285
++ ++ QL Q +++EE+ + + ++RE +E E EA+ RE S
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM--GREVNALKS 1926
Query: 286 KLRGSLP 292
KLRG P
Sbjct: 1927 KLRGPPP 1933
Score = 45.4 bits (106), Expect = 9e-05
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 55/360 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+EKE ++ + +AL+E L KE ELE T +L E++++ K
Sbjct: 1479 REKETKALS---LARALEEALEAKE---------------ELERTNKMLKAEMEDLVSSK 1520
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL-AKERAQHLVEFEEQALLFKE 122
++ + + +E+ + L ++ E++E EL A E A+ +E QAL K
Sbjct: 1521 DD----VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL--KG 1574
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ + L E++++ ++ +++ E + ++ D R R K+KL
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDL 1629
Query: 183 TEESNS----KEKEIENLKNLVA---EFESRLKKEIDSNDSV----------SENLRKEM 225
+++S +E+ I+ L+ L A +F+ L+ S D + +++L ++
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 226 EQKSDEL-------KRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
Q ++L K+ L + +L E+ S LQ+ RR +L E L + +
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 279 EQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGER-SLARLNSEKGIQIPNLRGVSK 337
+ +S LS T + A N R L R N E ++ + G K
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Score = 38.9 bits (89), Expect = 0.008
Identities = 40/188 (21%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+EE + E +K ++ QK + E +EL+ K S L +E L+E+L
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHS--------QLTEEKNLLQEQLQAETE 901
Query: 181 RYTEESNSKEK---EIENLKNLVAEFESRLKKEIDSNDSVSE----------NLRKEMEQ 227
Y E + + + + L+ ++ E E+RL++E D + +L +++E+
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE------TVRRECEERF-ELTEALSQAREQ 280
+ +++ L + + + ++E + + R+ EER +LT L++ E+
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 281 LLELSKLR 288
L+KL+
Sbjct: 1022 AKNLTKLK 1029
>gi|46852390 coiled-coil domain containing 6 [Homo sapiens]
Length = 474
Score = 72.4 bits (176), Expect = 7e-13
Identities = 91/388 (23%), Positives = 162/388 (41%), Gaps = 69/388 (17%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
KALQEE K I+ R AE E E + N +++ L+ E+E + ++++K
Sbjct: 85 KALQEENRDLRKASVTIQAR---AEQEEEF---ISNTLFKKIQALQKEKETLAVNYEKEE 138
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
E L L +KL+ + K ++E L +E+ EF+ L+ K+ KL+ D + Q
Sbjct: 139 EFLTNELSRKLMQLQHEKAELEQHLEQEQ-----EFQVNKLM-KKIKKLENDTISK--QL 190
Query: 138 VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLK 197
+++ ++E+ +L+ L QE L +L K + E +++++
Sbjct: 191 TLEQLRREKIDLE-----------NTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPV 239
Query: 198 NLVAEFESRLKKEIDSNDSVSENLR---KEMEQKSDELKRVMLAQT----QLIEQFNQSQ 250
+ + EIDS +++ ++R E+E+ +L+ L + Q +E+ +
Sbjct: 240 S-APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMR 298
Query: 251 EENTFLQETVRRECEERFELTEALSQAREQL---------------LELSKLRGSLPFSP 295
EEN LQ ++RE E R L LS++ L L + +P++P
Sbjct: 299 EENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTP 358
Query: 296 CSLSKGSLTSPAAAVSNH-----GERSLAR---------------LNSEKGIQIPNLRGV 335
S S SP + ++H SL R + + GI P+ R
Sbjct: 359 -SPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRS 417
Query: 336 SKPTTFPTSDKPKRVRSGVPILPQPHPP 363
+ P F P + P+ P P PP
Sbjct: 418 NSPDKFKRPTPPPSPNTQTPVQPPPPPP 445
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 71.6 bits (174), Expect = 1e-12
Identities = 87/352 (24%), Positives = 162/352 (46%), Gaps = 35/352 (9%)
Query: 4 KEKEDSLM-TCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
KE+ D + CQ + K QE +K E D K R+ E E ++ Q + + L +
Sbjct: 424 KEEADQIRKNCQDMIKTYQESEEIKSN-ELDAKLRVTKGELEKQM------QEKSDQLEM 476
Query: 63 KN----ERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFEEQA 117
+ E E + + ++ +++L+ TLR K+ ++ + + E EL+K + + + E Q
Sbjct: 477 HHAKIKELEDLKRTFKEGMDELR-TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQN 535
Query: 118 LLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDL---ITGATRDLRQEVTTLKEK 174
LL K +T QL + ++ + I+ K+E E L I+DL I G+ R E+ E+
Sbjct: 536 LLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS-RKRESELLLFTER 594
Query: 175 LHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELK- 233
L + + ESNS + + + + ++ +S+ ++ +N ++ L KE E + +E++
Sbjct: 595 LTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQT 654
Query: 234 ---RVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGS 290
+ QT++ Q +E L R+ +LT+ L QAR +L ++ GS
Sbjct: 655 LQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVES--GS 712
Query: 291 LPFSPCSL-----SKGSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVSK 337
S+ S GSL + ++A E N+ + + N V K
Sbjct: 713 YDKEVSSMGSRSSSSGSLNARSSAEDRSPE------NTGSSVAVDNFPQVDK 758
Score = 52.8 bits (125), Expect = 5e-07
Identities = 56/231 (24%), Positives = 112/231 (48%), Gaps = 33/231 (14%)
Query: 40 LAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL---QETLRQKLLSDDNWKE 96
L E E E+ T + R V N+ E L+ +K ++ QE + +KL+ ++ +
Sbjct: 163 LEEIESELLSTEFAEHR--VPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQ 220
Query: 97 KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDL 156
++ ++ E+ +EE K + + EK+ H + I++ + EEL ++
Sbjct: 221 ELFVDICSEKDN-----------LREELKKRTETEKQ-HMNTIKQLESRIEELNKEVK-- 266
Query: 157 ITGATRD--LRQEVTTLK--EKLHKSHTRYTEESNSK------EKEIENLKNLVAEFES- 205
A+RD + Q+VT ++LHK + E++N K EKE +K + E ES
Sbjct: 267 ---ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 323
Query: 206 RLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFL 256
L+KE ++ + + KE+E+ ++++K++ + +L + + + E T L
Sbjct: 324 DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRL 374
Score = 49.7 bits (117), Expect = 5e-06
Identities = 57/261 (21%), Positives = 121/261 (46%), Gaps = 42/261 (16%)
Query: 18 KALQEELTVKEKQEEDIKRR---INLAENELEITKTLLNQTREEVLTLKNERELMLISHQ 74
K LQ+E +K+ +E+ K + +++ + + + L +T E + ++L +
Sbjct: 201 KYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQL-----E 255
Query: 75 KSIEQLQETL---RQKLLSDDNWKEKIEAELAKERAQHLVEF---------EEQALLFK- 121
IE+L + + R +L++ D + +L KE AQ + + E++A++ K
Sbjct: 256 SRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKY 315
Query: 122 -EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
K LD+ KEK + + +K + +EL+ T + L QE K +LH+ +
Sbjct: 316 VRGEKESLDLRKEK-ETLEKKLRDANKELEKN-----TNKIKQLSQE----KGRLHQLYE 365
Query: 181 RYTEESNSKEKEIENLKNLVAEF-------ESRLKKEIDSNDSVSENLRK---EMEQKSD 230
E+ +EI+ LK + +++LK E+DS+ + L++ ++ Q +
Sbjct: 366 TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKE 425
Query: 231 ELKRVMLAQTQLIEQFNQSQE 251
E ++ +I+ + +S+E
Sbjct: 426 EADQIRKNCQDMIKTYQESEE 446
Score = 49.3 bits (116), Expect = 6e-06
Identities = 61/296 (20%), Positives = 129/296 (43%), Gaps = 44/296 (14%)
Query: 27 KEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELML---ISHQKSIEQLQET 83
K+ E++K+R + + K L ++ E +K R+ ++ ++ + +++QL +
Sbjct: 230 KDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKE 289
Query: 84 LRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDI-----EKEKHQDV 138
+ Q++ + E+ E +++ +E L KE+ L+ + E EK+ +
Sbjct: 290 MAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNK 349
Query: 139 IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE------------------------- 173
I++ +E+ L ++ + G T L +E+ LKE
Sbjct: 350 IKQLSQEKGRLH-QLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKE 408
Query: 174 ---KLHKSHTRYT---EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSE-NLRKEME 226
KL ++ T+ T EE++ K +++ E E E+D+ V++ L K+M+
Sbjct: 409 TKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQ 468
Query: 227 QKSDELK---RVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQARE 279
+KSD+L+ + L F + +E L+ V+ +ER + LS+ +E
Sbjct: 469 EKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKE 524
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 71.2 bits (173), Expect = 1e-12
Identities = 56/253 (22%), Positives = 124/253 (49%), Gaps = 11/253 (4%)
Query: 6 KEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE 65
KE + + + + E ++K EED +RR+ + + E + Q RE V +K E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 66 RELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKE-RAQHLVEFEEQALLFKEET 124
++ + I++ E +++ L+++ K+K A+ +E A+ E E + L +
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW---- 646
Query: 125 KLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGA-TRDLRQEVTTLKEKLHKSHTRYT 183
LQ + E+ +HQ+++QK K+E++E K ++ A R+ + +E+ + R
Sbjct: 647 -LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSV----SENLRKEMEQKSDELKRVMLAQ 239
+E +E+++ + + + ++E+ + E L++E+E+K + ++ LA+
Sbjct: 706 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 765
Query: 240 TQLIEQFNQSQEE 252
QL E+ + +E
Sbjct: 766 RQLQEEQEKKAKE 778
Score = 48.9 bits (115), Expect = 8e-06
Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 20/220 (9%)
Query: 81 QETLRQKLLSDDNWKEKIEAE-LAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVI 139
+E RQ+L +N + K EAE L +++ + + + K E +L+ ++ + + +
Sbjct: 531 KEKERQRL---ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM 587
Query: 140 QKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNL 199
++ KK+Q E + D T ++ R K+K E +E+E L+ L
Sbjct: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 200 VAEFESRLKKEI--DSNDSVSENLRK-----------EMEQKSDELKRVMLAQTQLIEQF 246
E E R +E+ + E LRK E E++ E + + + EQ
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 247 NQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+ QE L E RR +ER + L Q RE+ L L K
Sbjct: 708 RREQERQ--LAEQERRREQERLQAEREL-QEREKALRLQK 744
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/220 (24%), Positives = 95/220 (43%), Gaps = 45/220 (20%)
Query: 4 KEKEDSLMTCQQIYKAL---QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
K KE+ L + KA EE+ + KQEE+ +R L + E E
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE-------------- 653
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
+ +EL+ QK E+ QE LR K LA++R Q E E +
Sbjct: 654 --RRHQELL----QKKKEEEQERLR---------KAAEAKRLAEQREQERREQERREQER 698
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+E+ + + + +++ Q Q+ ++EQE LQ A R+L++ L +L K
Sbjct: 699 REQERREQERREQERQLAEQERRREQERLQ---------AERELQEREKAL--RLQKEQL 747
Query: 181 RYTEESNSKEKEIENL--KNLVAEFESRLKKEIDSNDSVS 218
+ E K++E + L + L E E + K+ ++ +++
Sbjct: 748 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALN 787
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 70.5 bits (171), Expect = 2e-12
Identities = 71/304 (23%), Positives = 143/304 (47%), Gaps = 23/304 (7%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
+K+ + L+ +++ + E + + ++E + N + +L + +++ E+ L
Sbjct: 892 IKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKEL 951
Query: 63 KNERELMLIS----HQKSIEQLQ------ETLRQKLLSD--DNWKEKIEAELAKERAQHL 110
K RE++L H ++ E+LQ ++L Q L + D + + E K H
Sbjct: 952 KQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHR 1011
Query: 111 VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
V EE K+E + ++ +E H ++IQ+ +K+ +EL++K+SDL TR +
Sbjct: 1012 VSLEE----LKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDL--SDTRCKLEVELA 1065
Query: 171 LKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD 230
LKE EES +++K E LK+L+ + L+ EI + ++ + +
Sbjct: 1066 LKEAETDEIKILLEESRAQQK--ETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123
Query: 231 ELKRVMLAQTQ--LIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLEL-SKL 287
EL+ +M + + E ++ +EE+ L+ + + + E +EQ++EL SKL
Sbjct: 1124 ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183
Query: 288 RGSL 291
L
Sbjct: 1184 DSEL 1187
Score = 48.5 bits (114), Expect = 1e-05
Identities = 82/346 (23%), Positives = 154/346 (44%), Gaps = 85/346 (24%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
L+ EL +KE + ++IK I L E+ + +TL + +E L+ E + Q + E
Sbjct: 1060 LEVELALKEAETDEIK--ILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNEN 1117
Query: 80 LQETLRQ--------------KLLSDDNWKEKI-EAELAKERAQHLVEFEEQALLFKEET 124
Q L + +L+S + I +AEL K + H FE + L ++
Sbjct: 1118 YQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII 1177
Query: 125 KLQ--LDIE---------------KEKHQDVIQKYKK-----------EQEELQMKIS-- 154
+LQ LD E +EK++ +IQ +K ++E+L K++
Sbjct: 1178 ELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCE 1237
Query: 155 --DLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLK----NLVAEFESRLK 208
+ I A ++ + E ++++L + ++ E +K I++ + +LVAE + +L+
Sbjct: 1238 KDEAIQTALKEFKLEREVVEKELLEK-VKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQ 1296
Query: 209 KEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRE----- 263
+E E L ++ ++K++E++ V +T LI + Q+ +E +R+E
Sbjct: 1297 EE---KAKFLEQLEEQEKRKNEEMQNV---RTSLIAE-QQTNFNTVLTREKMRKENIIND 1349
Query: 264 -----------CEERFELTEALSQAREQLL--------ELSKLRGS 290
E +L E+LS+ R +LL E+SKLR S
Sbjct: 1350 LSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSS 1395
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 70.5 bits (171), Expect = 2e-12
Identities = 71/304 (23%), Positives = 143/304 (47%), Gaps = 23/304 (7%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
+K+ + L+ +++ + E + + ++E + N + +L + +++ E+ L
Sbjct: 892 IKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKEL 951
Query: 63 KNERELMLIS----HQKSIEQLQ------ETLRQKLLSD--DNWKEKIEAELAKERAQHL 110
K RE++L H ++ E+LQ ++L Q L + D + + E K H
Sbjct: 952 KQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHR 1011
Query: 111 VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
V EE K+E + ++ +E H ++IQ+ +K+ +EL++K+SDL TR +
Sbjct: 1012 VSLEE----LKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDL--SDTRCKLEVELA 1065
Query: 171 LKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD 230
LKE EES +++K E LK+L+ + L+ EI + ++ + +
Sbjct: 1066 LKEAETDEIKILLEESRAQQK--ETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123
Query: 231 ELKRVMLAQTQ--LIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLEL-SKL 287
EL+ +M + + E ++ +EE+ L+ + + + E +EQ++EL SKL
Sbjct: 1124 ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183
Query: 288 RGSL 291
L
Sbjct: 1184 DSEL 1187
Score = 48.5 bits (114), Expect = 1e-05
Identities = 82/346 (23%), Positives = 154/346 (44%), Gaps = 85/346 (24%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
L+ EL +KE + ++IK I L E+ + +TL + +E L+ E + Q + E
Sbjct: 1060 LEVELALKEAETDEIK--ILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNEN 1117
Query: 80 LQETLRQ--------------KLLSDDNWKEKI-EAELAKERAQHLVEFEEQALLFKEET 124
Q L + +L+S + I +AEL K + H FE + L ++
Sbjct: 1118 YQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII 1177
Query: 125 KLQ--LDIE---------------KEKHQDVIQKYKK-----------EQEELQMKIS-- 154
+LQ LD E +EK++ +IQ +K ++E+L K++
Sbjct: 1178 ELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCE 1237
Query: 155 --DLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLK----NLVAEFESRLK 208
+ I A ++ + E ++++L + ++ E +K I++ + +LVAE + +L+
Sbjct: 1238 KDEAIQTALKEFKLEREVVEKELLEK-VKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQ 1296
Query: 209 KEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRE----- 263
+E E L ++ ++K++E++ V +T LI + Q+ +E +R+E
Sbjct: 1297 EE---KAKFLEQLEEQEKRKNEEMQNV---RTSLIAE-QQTNFNTVLTREKMRKENIIND 1349
Query: 264 -----------CEERFELTEALSQAREQLL--------ELSKLRGS 290
E +L E+LS+ R +LL E+SKLR S
Sbjct: 1350 LSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSS 1395
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 70.5 bits (171), Expect = 2e-12
Identities = 87/361 (24%), Positives = 158/361 (43%), Gaps = 57/361 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKR-RINLAE------------NELEITKT 50
+EKE ++ + +AL+E L KE+ E K+ R ++ + +ELE +K
Sbjct: 1479 REKETKALS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 51 LLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNW---KEKIEAELAKERA 107
L Q EE+ T E E ++LQ T KL + N K + E +L
Sbjct: 1536 ALEQQVEEMRTQLEELE----------DELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 108 QHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQE 167
Q+ E++ LL K+ +L+ ++E E+ Q + K++ E+ +K + A R E
Sbjct: 1586 QNE---EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 168 VTTLKEKLH---KSHTRYTEESNSKEKEI--------ENLKNLVAEFESRLKKEIDSNDS 216
V KL K + R EE+ + EI + LK+L AE +L++E+ S++
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI-LQLQEELASSER 1701
Query: 217 VSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQ 276
+ +E ++ +DE+ ++ L+++ + + L+E + E + EL +
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE-QSNMELLN--DR 1758
Query: 277 AREQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVS 336
R+ L++ L L + AA S++ + L R N E ++ L G
Sbjct: 1759 FRKTTLQVDTLNAEL----------AAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 337 K 337
K
Sbjct: 1809 K 1809
Score = 61.2 bits (147), Expect = 2e-09
Identities = 67/297 (22%), Positives = 135/297 (45%), Gaps = 28/297 (9%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREE----VLTLKNERELM------- 69
+EEL K+++ +K + E ELE + Q EE L+ E EL
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 70 --LISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
L + ++ +E++ L ++ ++ + ++ E K +A H+ + EEQ L +E + +
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA-HIQDLEEQ-LDEEEGARQK 968
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESN 187
L +EK + I+K ++E L+ + S I +E +++++ + ++ EE
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFI--------KEKKLMEDRIAECSSQLAEE-E 1019
Query: 188 SKEKEIENLKN----LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K K + ++N ++++ E RLKKE + + + RK + +D ++ Q Q+
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300
E Q ++ LQ + R +E AL RE ++++L+ S +K
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/299 (20%), Positives = 129/299 (43%), Gaps = 46/299 (15%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT 61
+++E + + Q+ +++ + EKQ+ D+ + + ELE TL ++ L
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE--DTLDTTAAQQELR 1169
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
K E+E + +L++ L ++ + EA++ R +H EE + +
Sbjct: 1170 TKREQE---------VAELKKALEEETKNH-------EAQIQDMRQRHATALEELSEQLE 1213
Query: 122 EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTR 181
+ + + ++EK K Q + + +EL ++ L Q+V E K
Sbjct: 1214 QAKRFKANLEKNK-----QGLETDNKELACEVKVL---------QQVKAESEHKRKKLDA 1259
Query: 182 YTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKE----------MEQKSDE 231
+E ++K E + L+ +AE S+L+ E+D+ ++ E K+ +E + +
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 232 LKRVMLAQTQ----LIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+ ++ +T+ L + Q +EE LQE E E R L + + + QL + K
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Score = 54.7 bits (130), Expect = 1e-07
Identities = 69/299 (23%), Positives = 125/299 (41%), Gaps = 45/299 (15%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKR-RINLAE---NELEITKTLLNQTRE-E 58
KE E L + + LQEEL E+ ++ R LA+ N LL++ R E
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 59 VLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQAL 118
+ E EL Q ++E L + R+ L D + AELA ER+
Sbjct: 1736 ARIAQLEEELE--EEQSNMELLNDRFRKTTLQVDT----LNAELAAERSA---------- 1779
Query: 119 LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKS 178
+K + Q+ +++ +EL+ K+ +L + ++ L+ K+ +
Sbjct: 1780 -------------AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 179 HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLA 238
+ +E+ KE+ N LV E +LK+ E+ R+ +Q +++++
Sbjct: 1827 EEQLEQEA--KERAAAN--KLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKANAR 1878
Query: 239 QTQLIEQFNQSQEENT---FLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFS 294
QL Q +++EE T + ++RE ++ E E LS+ L + G + FS
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFS 1937
Score = 52.4 bits (124), Expect = 7e-07
Identities = 72/298 (24%), Positives = 133/298 (44%), Gaps = 35/298 (11%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+EK +L + + + +L + K+EE ++ + A+ +L+ T L E+
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEA-ELAKERAQHLVEFEEQALLFKE 122
+E +L L K E+LQ L + DD K A ++ +E + E +E F+
Sbjct: 1079 DELKLQL---AKKEEELQGALAR---GDDETLHKNNALKVVRELQAQIAELQED---FES 1129
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLI--TGATRDLR----QEVTTLKEKLH 176
E + EK+K + +E E L+ ++ D + T A ++LR QEV LK+ L
Sbjct: 1130 EKASRNKAEKQK-----RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 177 KSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKE---MEQKSDELK 233
EE+ + E +I++++ A L ++++ NL K +E + EL
Sbjct: 1185 -------EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237
Query: 234 -RVMLAQTQLIEQFNQSQEENTFLQETVRRECEE---RFELTEALSQAREQLLELSKL 287
V + Q E ++ ++ + +QE + E R EL E S+ + +L +S L
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Score = 52.4 bits (124), Expect = 7e-07
Identities = 66/310 (21%), Positives = 139/310 (44%), Gaps = 21/310 (6%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINL------AENELEITKTLLNQ 54
+L +E L +I + +E+ +++E+QEE+ + R NL +++L TK ++
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 55 TREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFE 114
+ +L+ ++ +L K E L + L +K L+ D EK + L +E V+ +
Sbjct: 1383 DLGTIESLEEAKKKLL----KDAEALSQRLEEKALAYDK-LEKTKNRLQQELDDLTVDLD 1437
Query: 115 EQ----ALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
Q + L K++ K + +EK + +Y +E++ + + + T A R
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEK--SISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 171 LKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD 230
L+ K + R ++ + +++ + K+ V + L+K + + E +R ++E+ D
Sbjct: 1496 LEAK--EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 231 ELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGS 290
EL+ A+ +L + N + F ++ R+ + + + Q RE EL R
Sbjct: 1554 ELQATEDAKLRL--EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 291 LPFSPCSLSK 300
+ S K
Sbjct: 1612 RALAVASKKK 1621
Score = 52.0 bits (123), Expect = 9e-07
Identities = 68/341 (19%), Positives = 155/341 (45%), Gaps = 50/341 (14%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV-LTL 62
K+ +D L T + + +A ++ L E + ++ + LA ++LE TK L Q +++ + L
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA-LAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
++R++ ++E+ Q+ Q L + + I A A+ER + E E KE
Sbjct: 1437 DHQRQVA-----SNLEKKQKKFDQLLAEE----KSISARYAEERDRAEAEARE-----KE 1482
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITG-------------ATRDLRQEVT 169
L L E+ + ++++++ ++L+ + DL++ + R L Q+V
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
++ +L + ++K + N++ + A+FE L+ ++++
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR---------------DEQN 1587
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE----ERFELTEALSQAREQLL-EL 284
+E KR+++ Q + +E + + + L +++ E + EA ++AR++++ +L
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 285 SKLRGSLPFSPCSLSKGSLT-SPAAAVSNHGERSLARLNSE 324
KL+ + L + + A S E+ L L +E
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Score = 51.6 bits (122), Expect = 1e-06
Identities = 70/264 (26%), Positives = 115/264 (43%), Gaps = 42/264 (15%)
Query: 29 KQEEDIKRRINLAE------NELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQE 82
K E + R+ LAE NEL+ TLL + ++ + + + Q + E LQE
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326
Query: 83 TLRQKLLSDDNWKEKI-EAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQK 141
RQKL N +I + E K Q E EE+A E+ L L Q +
Sbjct: 1327 ETRQKL----NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL-------QSQLAD 1375
Query: 142 YKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVA 201
KK+ ++ + + + A + L ++ L ++L + Y ++E KN +
Sbjct: 1376 TKKKVDD-DLGTIESLEEAKKKLLKDAEALSQRLEEKALAY--------DKLEKTKNRLQ 1426
Query: 202 EFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVR 261
+ L ++D V+ NL K+ ++K D+L LA+ + I + +E R
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKK-QKKFDQL----LAEEKSISA--------RYAEERDR 1473
Query: 262 RECEERFELTEALSQAR--EQLLE 283
E E R + T+ALS AR E+ LE
Sbjct: 1474 AEAEAREKETKALSLARALEEALE 1497
Score = 44.7 bits (104), Expect = 1e-04
Identities = 73/317 (23%), Positives = 136/317 (42%), Gaps = 46/317 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELE-ITKTLLNQTREEV-- 59
++ K L+ + I + T + E+++ R+ + ELE I L ++ EE
Sbjct: 878 MERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937
Query: 60 -LTLKNERELMLISHQKSIEQL--QETLRQKLLSDDNWKEKIEAELA-KERAQHLVEFEE 115
L+NE++ M Q EQL +E RQKL EK+ AE K+ + ++ E+
Sbjct: 938 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL-----EKVTAEAKIKKMEEEILLLED 992
Query: 116 QALLFKEETKLQLD---------IEKEKHQDVIQKYKKEQEELQMKISDL---------- 156
Q F +E KL D E+E+ + K + +QE + ISDL
Sbjct: 993 QNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM---ISDLEERLKKEEKT 1049
Query: 157 ---ITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDS 213
+ A R L E T L++++ + + E K+ E L+ +A + + ++
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 214 NDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEA 273
V E L+ ++ + ++ + ++ + +Q EE E ++ E E+ + T A
Sbjct: 1110 LKVVRE-LQAQIAELQEDFESEKASRNKAEKQKRDLSEE----LEALKTELEDTLDTTAA 1164
Query: 274 LSQAR----EQLLELSK 286
+ R +++ EL K
Sbjct: 1165 QQELRTKREQEVAELKK 1181
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 70.5 bits (171), Expect = 2e-12
Identities = 82/366 (22%), Positives = 165/366 (45%), Gaps = 84/366 (22%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+++E + T Q + E+L V E + E++K+ + L++++ L+Q RE +L +
Sbjct: 754 QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM----LKLSEVRLSQQRESLLAEQ 809
Query: 64 NERELMLISHQ--KSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
+ L+L + Q + I + ET ++ LS EK+E E++ + + E E++ L +
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLSSQI--EKLEHEISHLKKKLENEVEQRHTLTR 867
Query: 122 E------ETKLQLDIEKEKH---QDVIQKYKKEQEELQMKISDL---------------- 156
+TK QLD E H +++++ +KE L+ +S++
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
Query: 157 ---------ITGATRDLRQEVTTLKEKLHKSHTRYT---------EESNSKEKEI--ENL 196
+ R ++V LKE+L S + EES +KEK++ E
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
Query: 197 KNLV------AEFESRLKKEIDSNDSVSENLRKE-------MEQKSDELKRVMLAQTQLI 243
KN+ AEF+++L+K++ + + L+ + MEQ+ ELK+ + + +
Sbjct: 988 KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV 1047
Query: 244 EQFNQSQEENTFLQETVRRECEERFEL------------------TEALSQAREQLLELS 285
++ Q ++ RR+C+E+ ++ EAL A+EQ+ +++
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
Query: 286 KLRGSL 291
+R L
Sbjct: 1108 SVRQHL 1113
Score = 59.7 bits (143), Expect = 4e-09
Identities = 69/283 (24%), Positives = 127/283 (44%), Gaps = 31/283 (10%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVK----EKQEEDIKRRINLAENELE-ITKTL--LNQT 55
L EK L Q A+Q + T E ++ D+ R ELE +T+ + LN+
Sbjct: 92 LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEK 151
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
+E T K E +L L Q S + R+K L + KE + ++ + + +E
Sbjct: 152 LKESNTTKGELQLKLDELQAS--DVSVKYREKRLEQE--KELLHSQNTWLNTELKTKTDE 207
Query: 116 QALLFKE------ETKLQLDIEKE---KHQDVIQKYKKEQEELQMKISDLITGATRDLRQ 166
L +E E K L+ +KE + ++ + K E LQ + DL+T ++ ++
Sbjct: 208 LLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLT-KLKEAKE 266
Query: 167 EVTTLKEKLH-------KSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSE 219
+ +++EK H K Y ++ E + L V E LK+ ++N ++ +
Sbjct: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
Query: 220 NLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRR 262
+L E+EQ D++++ ML + +E+ + + N L T R+
Sbjct: 327 HL-LEVEQSKDQMEKEMLEKIGRLEK--ELENANDLLSATKRK 366
Score = 58.9 bits (141), Expect = 7e-09
Identities = 82/342 (23%), Positives = 143/342 (41%), Gaps = 61/342 (17%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
KEK ++ + + LQE++T Q I +++ A E+ + + R E+ +L
Sbjct: 684 KEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLH 743
Query: 64 NERELMLISHQKSIEQLQETLRQKL-------------------------LSDDNWKEKI 98
+ + + QK EQ+ T+ Q L LS+ ++
Sbjct: 744 ERNQKLTATTQKQ-EQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR 802
Query: 99 EAELAKERAQHLVEFEEQAL-----LFKEETKLQLDIEKEKHQDVIQKYKKEQE-ELQMK 152
E+ LA++R Q+L+ Q + + ETK +L + EK + I KK+ E E++ +
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR 862
Query: 153 ISDLITGATRDLRQEVTTLKEKLHKS---HTRYTEESNSKEKEIENLKNLVAEFE----- 204
+ TR+L ++ K +L H E + +KEI LK ++ E
Sbjct: 863 HT-----LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS 917
Query: 205 ---SRLKKEIDSN----DSVSENLRKEMEQKSDELKRVMLAQTQLIEQF-------NQSQ 250
R K SN D + LR+ EQ +D LK + T +EQ+ +S
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND-LKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 251 EENTFLQETVRRECEERF-ELTEALSQAREQLLELSKLRGSL 291
+ + E VR+ E R E E +Q ++L+E+ K + L
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Score = 52.0 bits (123), Expect = 9e-07
Identities = 61/286 (21%), Positives = 129/286 (45%), Gaps = 17/286 (5%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKN 64
E E ++ QE L + ++ + ++ + N+L K L + +E L +
Sbjct: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL---KALTEKNKE--LEIAQ 103
Query: 65 ERELMLISH-QKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
+R + + S ++ E+L+ R + +++ + E E E + L E +++ K E
Sbjct: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ--ELEYLTEDVKRLNEKLKESNTTKGE 161
Query: 124 TKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
LQL +++ + DV KY++++ E + +L+ L E+ T ++L
Sbjct: 162 --LQLKLDELQASDVSVKYREKRLEQE---KELLHSQNTWLNTELKTKTDELLALGREKG 216
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
E + +EN K V SRL+++++ + +E+L+K +E +LK Q +
Sbjct: 217 NEILELKCNLENKKEEV----SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRG 289
E+F+ + L + ++ + L++A E+L +L K G
Sbjct: 273 EKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAG 318
Score = 49.7 bits (117), Expect = 5e-06
Identities = 69/339 (20%), Positives = 153/339 (45%), Gaps = 31/339 (9%)
Query: 3 LKEKEDSLMTC--QQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
LK K D L+ ++ + L+ + ++ K+EE R+ N L+ + L + E++L
Sbjct: 201 LKTKTDELLALGREKGNEILELKCNLENKKEE--VSRLEEQMNGLKTSNEHLQKHVEDLL 258
Query: 61 T-LKNERELMLISHQKSIEQLQETLR----QKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
T LK +E +K +L ++ K +DD+ + E A E L++
Sbjct: 259 TKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAG 318
Query: 116 QALLFKEETKLQLDIEKEK-HQDVIQKYKKEQEELQMKISDLITGATRD----LRQEVTT 170
+A ++ L+++ K++ +++++K + ++EL+ +DL++ R +E+
Sbjct: 319 EANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELE-NANDLLSATKRKGAILSEEELAA 377
Query: 171 LKE------KLHKSHTRYTEESNSKEKE-----IENLKNL-VAEFESRLKKEIDSNDSVS 218
+ K+ K + TE N+ + +E L+N + ++ + KE+++ +
Sbjct: 378 MSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPIL 437
Query: 219 ENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFL--QETVRRECEERFELT--EAL 274
+ R+E E+ + + + Q +++ + QE+ Q +V R E+ +
Sbjct: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
Query: 275 SQAREQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNH 313
Q R L+EL + RG+ +S ++S + +S H
Sbjct: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH 536
Score = 43.9 bits (102), Expect = 2e-04
Identities = 77/360 (21%), Positives = 158/360 (43%), Gaps = 56/360 (15%)
Query: 9 SLMTCQQIYKALQEEL----TVKEKQEEDIKRRI-NLAENELEIT--KTLLNQTREEVLT 61
SL Q + ++L+E+L T KE ++D+ +I ++ E IT K + + + +
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 62 LKNERELMLIS-------HQK---SIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLV 111
LK +++ ++ + HQ+ S++++QE L++ L + + +E+++ + + L
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQE-LKETLNQAETKSKSLESQV-ENLQKTLS 1505
Query: 112 EFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTL 171
E E +A +E+T +QL E + + +Q ++E+L+ + IT R+ +
Sbjct: 1506 EKETEARNLQEQT-VQLQSELSRLRQDLQDRTTQEEQLRQQ----ITEKEEKTRKAIVAA 1560
Query: 172 KEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDE 231
K K+ +H ++ +KE E +N L ++ D D L+ + E +
Sbjct: 1561 KSKI--AHLAGVKDQLTKENEELKQRN------GALDQQKDELDVRITALKSQYEGRISR 1612
Query: 232 LKRVMLA-QTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGS 290
L+R + Q + +EQ ++ QE + + E Q R+ L+ + G
Sbjct: 1613 LERELREHQERHLEQRDEPQEPSNKVPE-----------------QQRQITLKTTPASGE 1655
Query: 291 LPFSPCSLSKGSLTSPAAAVSNHGERSLARLNSEKGIQIPNLR------GVSKPTTFPTS 344
+ S + P VS + + A + K ++R V+ PTT PT+
Sbjct: 1656 RGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTA 1715
Score = 41.2 bits (95), Expect = 0.002
Identities = 71/319 (22%), Positives = 126/319 (39%), Gaps = 60/319 (18%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELT-VKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
L +K ++ + +Q L++ L+ V+ + +E ++R NE + + Q + V
Sbjct: 1018 LQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVE 1077
Query: 61 TL-KNERELMLISHQKSIEQLQETLRQ--KLLSDDNWKEKIEAELAKERAQHLVEFEEQA 117
K ERELML H +E LQ Q K+ S E+ + + + +EE+
Sbjct: 1078 AQNKYERELML--HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE 1135
Query: 118 LLFKEETKLQL----DIEK---------EKHQDVIQKYKKEQEELQMKIS--------DL 156
+ K+E + D+EK EK D + KE + + +S +
Sbjct: 1136 RMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195
Query: 157 ITGATRDLRQE---VTTLKEKLHKSHTRYTEESNSKEKEIENLKN--------------L 199
I R +R+E T E RY + E+E++ L++
Sbjct: 1196 ILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKT 1255
Query: 200 VAEFESRLKKEIDSNDSVSEN--LRKEMEQKSDELKRVML--------------AQTQLI 243
+A+ E +KK N + N LR+E E+ +L+++ A +L
Sbjct: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
Query: 244 EQFNQSQEENTFLQETVRR 262
E+ Q E L+E V+R
Sbjct: 1316 EKSGMLQAEKKLLEEDVKR 1334
Score = 38.1 bits (87), Expect = 0.014
Identities = 75/313 (23%), Positives = 128/313 (40%), Gaps = 52/313 (16%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQK---- 75
LQE+ KQ ++R E ++ K L Q R ++ L+ R +I ++
Sbjct: 468 LQEDTDKANKQSSVLERDNRRMEIQV---KDLSQQIRVLLMELEEARGNHVIRDEEVSSA 524
Query: 76 SIEQLQETLRQKLLSDDNWKEKIEAE----LAKERAQHLVEFEEQALLFKEETKLQLDIE 131
I E + Q L+S N +E + +A E EEQ + T+LQL +E
Sbjct: 525 DISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLE 584
Query: 132 KEKHQDVIQKYKKEQEELQMKISDLITGAT---RDLRQEVTTLKEKLHKSH--------- 179
+ +++ +K ++ QM++ D I R L + T + LH S
Sbjct: 585 SALTE--LEQLRKSRQH-QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
Query: 180 -----TRYTEESNSKEKEIEN---------LKNLVAEFESRLKKEIDSNDSVSENLRKEM 225
T T + + IE+ LK L FE+ K++ ++ +E L K
Sbjct: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
Query: 226 EQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETV---RRE---CEERFELTEALSQARE 279
EQ +D + T++ Q + + + LQ+ V RRE ER + A +Q +E
Sbjct: 702 EQVTD----LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
Query: 280 QLLE--LSKLRGS 290
Q++ LRG+
Sbjct: 758 QIINTMTQDLRGA 770
Score = 36.2 bits (82), Expect = 0.052
Identities = 46/211 (21%), Positives = 97/211 (45%), Gaps = 27/211 (12%)
Query: 17 YKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKN---ERELMLISH 73
Y Q++L +++ + + I + ++ E+E +L + REE + + L
Sbjct: 402 YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
Query: 74 QKSIEQLQE-----TLRQKLLSDDNWKEKIEA-ELAKERAQHLVEFEEQA--LLFKEETK 125
K I++LQE + +L DN + +I+ +L+++ L+E EE + ++E
Sbjct: 462 MKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEV 521
Query: 126 LQLDIEKEKHQDVIQKY---KKEQEELQMKISDLIT-----GATRDLRQEVTT------L 171
DI +VI ++ + EELQ + L+ G TR+ ++ TT L
Sbjct: 522 SSADISSS--SEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITEL 579
Query: 172 KEKLHKSHTRYTEESNSKEKEIENLKNLVAE 202
+ KL + T + S++ +++ + ++V +
Sbjct: 580 QLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610
Score = 34.3 bits (77), Expect = 0.20
Identities = 37/156 (23%), Positives = 68/156 (43%), Gaps = 11/156 (7%)
Query: 143 KKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAE 202
+ E +L + + + D + E+ LK + H ++ ES + EIE + E
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGR----HEKFKVESEQQYFEIEKRLSHSQE 66
Query: 203 FESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI---EQFNQSQEE----NTF 255
+E S E L +++ +++ K + +AQ + I QF +++EE
Sbjct: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
Query: 256 LQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
L T R +E LTE + + E+L E + +G L
Sbjct: 127 LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGEL 162
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 69.3 bits (168), Expect = 6e-12
Identities = 70/298 (23%), Positives = 137/298 (45%), Gaps = 31/298 (10%)
Query: 14 QQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE-------- 65
+Q + L+E LT KE++ ++ ++ LE +T+LN+ +++ + E
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 66 ---------RELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEA-ELAKERAQHLVEFEE 115
+E + QK IE LQE LR K + KE++++ + + E
Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
Query: 116 QALLFKEET----KLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTL 171
+AL KE T K Q D ++ + Q+ I YKK+ ++L+ K+S L+ G + + L
Sbjct: 620 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS-LLQGDLSEKEASLLDL 678
Query: 172 KE---KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
KE L S + + E +E K + ES+LKK ++ ++ EM +
Sbjct: 679 KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA--ALEARASPEMSDR 736
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
L+R + T+ ++ +++Q E L E ++ E+ + + +++ Q+ + +K
Sbjct: 737 IQHLEREI---TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/300 (25%), Positives = 142/300 (47%), Gaps = 39/300 (13%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT 61
+L KE + Q+ + LQE+L KEKQ +K R+ + + T T L T EE L
Sbjct: 565 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALT-TLEEALA 623
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK---------ERAQHLVE 112
K ER + + Q+ ++ R+K DN+K+ ++ K E+ L++
Sbjct: 624 EK-ERTIERLKEQRDRDE-----REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD 677
Query: 113 FEEQALL-----FKEETKLQ-----LDIEKEKHQDVIQKYKKEQE-ELQMKISDLITGAT 161
+E A K++++L+ L+ +KE+ + + KK E L+ + S ++
Sbjct: 678 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI 737
Query: 162 RDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN----LVAEFESRLKKEIDSNDSV 217
+ L +E+T K++ K+ + KE+EN KN +AE E ++K D N V
Sbjct: 738 QHLEREITRYKDESSKAQAE-VDRLLEILKEVENEKNDKDKKIAELERQVK---DQNKKV 793
Query: 218 SENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQA 277
+ KE +K + + A+ + + N S ++ LQ+++R++ + EL EAL ++
Sbjct: 794 ANLKHKEQVEKKKSAQMLEEARRR-EDNLNDSSQQ---LQDSLRKKDDRIEELEEALRES 849
Score = 63.5 bits (153), Expect = 3e-10
Identities = 57/275 (20%), Positives = 130/275 (47%), Gaps = 12/275 (4%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL 80
QEE+ +K +D+K +++L + +L + L +E +L + L S K++E
Sbjct: 644 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG-LKKDSRLKTLEIA 702
Query: 81 QETLRQKLLSDDNWKEK-----IEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKH 135
E +++ L ++ +K +EA + E + + E + +K+E+ + E ++
Sbjct: 703 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS-KAQAEVDRL 761
Query: 136 QDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
+++++ + E+ + KI++L +D ++V LK K + + + +N
Sbjct: 762 LEILKEVENEKNDKDKKIAEL-ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 820
Query: 196 LKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQ-EENT 254
L + + + L+K+ D + + E LR+ ++ ++ + ++LAQ + + Q EE
Sbjct: 821 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE--REMVLAQEESARTNAEKQVEELL 878
Query: 255 FLQETVRRECEE-RFELTEALSQAREQLLELSKLR 288
E V++E E + +L+ E+ L+ LR
Sbjct: 879 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR 913
Score = 52.8 bits (125), Expect = 5e-07
Identities = 74/303 (24%), Positives = 132/303 (43%), Gaps = 28/303 (9%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKT-LLNQTREEVLT 61
L+ + D QQ + E V E EE+ +R AE+E + + LL +T EE+
Sbjct: 236 LRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH--AEHERQAKELFLLRKTLEEMEL 293
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
++ L + +SI++L E L+ K LS +E E A+ V E L K
Sbjct: 294 RIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 122 EETKLQLDIEKEKHQDVIQ---KYKKEQEELQMKISDL--ITGATRDLRQEVTTLKE--- 173
E+ L E + + K K Q ++MK S + + RDL +E+ LK
Sbjct: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
Query: 174 -------------KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSEN 220
++++SH+++ + N E+ E L + A++E KK + +
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMK--NKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ- 470
Query: 221 LRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQ 280
+++E+ +K EL + L QF+ S++ L+E++ + E+R + + A
Sbjct: 471 VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK-EQRAAILQTEVDALRL 529
Query: 281 LLE 283
LE
Sbjct: 530 RLE 532
Score = 37.0 bits (84), Expect = 0.030
Identities = 54/271 (19%), Positives = 107/271 (39%), Gaps = 47/271 (17%)
Query: 6 KEDSLMTCQQIYKALQEEL--TVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+E +T ++ QEE T EKQ E++ + + ELE K L+ T++ + +
Sbjct: 847 RESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
+ +K +E++ E ++ LL+ + K +A +A
Sbjct: 907 THLTNLRAERRKHLEEVLEMKQEALLAAISEK---DANIA-------------------- 943
Query: 124 TKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
L+L K+K Q+ + K+E++ L ++ + + + SH+ T
Sbjct: 944 -LLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE--DDHFKSSHSNQT 1000
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDS----------------NDSVSENLRKEMEQ 227
S ++ I+ L L + S+LK I S NL +
Sbjct: 1001 NHKPSPDQIIQPLLEL-DQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAA 1059
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE 258
+EL++ + + QL ++ + + +N LQE
Sbjct: 1060 WENELQK--MTRGQLQDELEKGERDNAELQE 1088
Score = 30.8 bits (68), Expect = 2.2
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 191 KEIENLKNLVAEFESRLKKEIDSNDSV-SENLRKEMEQKSDELKRVMLAQTQLIEQFNQS 249
+E + L+ V ES+L ++S + S L+KE + DE ++ + + EQ+
Sbjct: 163 RENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK----EQYRVV 218
Query: 250 QEENTFLQETVRRECEERFELTEALSQAREQ 280
QEEN +Q T+ + ++ + L+Q +Q
Sbjct: 219 QEENQHMQMTI-QALQDELRIQRDLNQLFQQ 248
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 69.3 bits (168), Expect = 6e-12
Identities = 70/298 (23%), Positives = 137/298 (45%), Gaps = 31/298 (10%)
Query: 14 QQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE-------- 65
+Q + L+E LT KE++ ++ ++ LE +T+LN+ +++ + E
Sbjct: 472 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
Query: 66 ---------RELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEA-ELAKERAQHLVEFEE 115
+E + QK IE LQE LR K + KE++++ + + E
Sbjct: 532 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 591
Query: 116 QALLFKEET----KLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTL 171
+AL KE T K Q D ++ + Q+ I YKK+ ++L+ K+S L+ G + + L
Sbjct: 592 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS-LLQGDLSEKEASLLDL 650
Query: 172 KE---KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK 228
KE L S + + E +E K + ES+LKK ++ ++ EM +
Sbjct: 651 KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA--ALEARASPEMSDR 708
Query: 229 SDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
L+R + T+ ++ +++Q E L E ++ E+ + + +++ Q+ + +K
Sbjct: 709 IQHLEREI---TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 763
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/300 (25%), Positives = 142/300 (47%), Gaps = 39/300 (13%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT 61
+L KE + Q+ + LQE+L KEKQ +K R+ + + T T L T EE L
Sbjct: 537 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALT-TLEEALA 595
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK---------ERAQHLVE 112
K ER + + Q+ ++ R+K DN+K+ ++ K E+ L++
Sbjct: 596 EK-ERTIERLKEQRDRDE-----REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD 649
Query: 113 FEEQALL-----FKEETKLQ-----LDIEKEKHQDVIQKYKKEQE-ELQMKISDLITGAT 161
+E A K++++L+ L+ +KE+ + + KK E L+ + S ++
Sbjct: 650 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI 709
Query: 162 RDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN----LVAEFESRLKKEIDSNDSV 217
+ L +E+T K++ K+ + KE+EN KN +AE E ++K D N V
Sbjct: 710 QHLEREITRYKDESSKAQAE-VDRLLEILKEVENEKNDKDKKIAELERQVK---DQNKKV 765
Query: 218 SENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQA 277
+ KE +K + + A+ + + N S ++ LQ+++R++ + EL EAL ++
Sbjct: 766 ANLKHKEQVEKKKSAQMLEEARRR-EDNLNDSSQQ---LQDSLRKKDDRIEELEEALRES 821
Score = 63.5 bits (153), Expect = 3e-10
Identities = 57/275 (20%), Positives = 130/275 (47%), Gaps = 12/275 (4%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL 80
QEE+ +K +D+K +++L + +L + L +E +L + L S K++E
Sbjct: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG-LKKDSRLKTLEIA 674
Query: 81 QETLRQKLLSDDNWKEK-----IEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKH 135
E +++ L ++ +K +EA + E + + E + +K+E+ + E ++
Sbjct: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS-KAQAEVDRL 733
Query: 136 QDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIEN 195
+++++ + E+ + KI++L +D ++V LK K + + + +N
Sbjct: 734 LEILKEVENEKNDKDKKIAEL-ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 792
Query: 196 LKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQ-EENT 254
L + + + L+K+ D + + E LR+ ++ ++ + ++LAQ + + Q EE
Sbjct: 793 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE--REMVLAQEESARTNAEKQVEELL 850
Query: 255 FLQETVRRECEE-RFELTEALSQAREQLLELSKLR 288
E V++E E + +L+ E+ L+ LR
Sbjct: 851 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR 885
Score = 37.0 bits (84), Expect = 0.030
Identities = 54/271 (19%), Positives = 107/271 (39%), Gaps = 47/271 (17%)
Query: 6 KEDSLMTCQQIYKALQEEL--TVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+E +T ++ QEE T EKQ E++ + + ELE K L+ T++ + +
Sbjct: 819 RESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 878
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
+ +K +E++ E ++ LL+ + K +A +A
Sbjct: 879 THLTNLRAERRKHLEEVLEMKQEALLAAISEK---DANIA-------------------- 915
Query: 124 TKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
L+L K+K Q+ + K+E++ L ++ + + + SH+ T
Sbjct: 916 -LLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE--DDHFKSSHSNQT 972
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDS----------------NDSVSENLRKEMEQ 227
S ++ I+ L L + S+LK I S NL +
Sbjct: 973 NHKPSPDQIIQPLLEL-DQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAA 1031
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQE 258
+EL++ + + QL ++ + + +N LQE
Sbjct: 1032 WENELQK--MTRGQLQDELEKGERDNAELQE 1060
Score = 30.8 bits (68), Expect = 2.2
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 191 KEIENLKNLVAEFESRLKKEIDSNDSV-SENLRKEMEQKSDELKRVMLAQTQLIEQFNQS 249
+E + L+ V ES+L ++S + S L+KE + DE ++ + + EQ+
Sbjct: 163 RENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK----EQYRVV 218
Query: 250 QEENTFLQETVRRECEERFELTEALSQAREQ 280
QEEN +Q T+ + ++ + L+Q +Q
Sbjct: 219 QEENQHMQMTI-QALQDELRIQRDLNQLFQQ 248
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 69.3 bits (168), Expect = 6e-12
Identities = 53/232 (22%), Positives = 117/232 (50%), Gaps = 11/232 (4%)
Query: 27 KEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQ 86
++K EED +RR+ + + E + Q RE V +K E++ + I++ E ++
Sbjct: 556 RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Query: 87 KLLSDDNWKEKIEAELAKE-RAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKE 145
+ L+++ K+K A+ +E A+ E E + L + LQ + E+ +HQ+++QK K+E
Sbjct: 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW-----LQQEEEERRHQELLQKKKEE 670
Query: 146 QEELQMKISDLITGA-TRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFE 204
++E K ++ A R+ + +E+ + R +E +E+++ + +
Sbjct: 671 EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQER 730
Query: 205 SRLKKEIDSNDSV----SENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEE 252
+ ++E+ + E L++E+E+K + ++ LA+ QL E+ + +E
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
Score = 48.5 bits (114), Expect = 1e-05
Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 82 ETLRQKLLSDDNWKEKIEAE-LAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQ 140
E RQ+L +N + K EAE L +++ + + + K E +L+ ++ + + ++
Sbjct: 536 EKERQRL---ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 592
Query: 141 KYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLV 200
+ KK+Q E + D T ++ R K+K E +E+E L+ L
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 201 AEFESRLKKEI--DSNDSVSENLRK-----------EMEQKSDELKRVMLAQTQLIEQFN 247
E E R +E+ + E LRK E E++ E + + + EQ
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
+ QE L E RR +ER + L Q RE+ L L K
Sbjct: 713 REQERQ--LAEQERRREQERLQAEREL-QEREKALRLQK 748
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/220 (24%), Positives = 95/220 (43%), Gaps = 45/220 (20%)
Query: 4 KEKEDSLMTCQQIYKAL---QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
K KE+ L + KA EE+ + KQEE+ +R L + E E
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE-------------- 657
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
+ +EL+ QK E+ QE LR K LA++R Q E E +
Sbjct: 658 --RRHQELL----QKKKEEEQERLR---------KAAEAKRLAEQREQERREQERREQER 702
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
+E+ + + + +++ Q Q+ ++EQE LQ A R+L++ L +L K
Sbjct: 703 REQERREQERREQERQLAEQERRREQERLQ---------AERELQEREKAL--RLQKEQL 751
Query: 181 RYTEESNSKEKEIENL--KNLVAEFESRLKKEIDSNDSVS 218
+ E K++E + L + L E E + K+ ++ +++
Sbjct: 752 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALN 791
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 68.2 bits (165), Expect = 1e-11
Identities = 85/334 (25%), Positives = 143/334 (42%), Gaps = 52/334 (15%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT 61
L K+ + + T + + L+ EL KQ + ++ +++LE + + +V
Sbjct: 803 LEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKE 862
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
LK E E + K I++LQ N KE + +L + A+ E E+ A
Sbjct: 863 LKEEIEEKNRENLKKIQELQ-----------NEKETLATQL--DLAETKAESEQLARGLL 909
Query: 122 EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD---LRQEVTTLKEKLHKS 178
EE +L E +K ++ +++ ++ + + T+D LR+E L EK+ K+
Sbjct: 910 EEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKA 969
Query: 179 HTRYTEESNSKEKEIENLK------------------NLVAEFESRLKKEIDSNDSVSEN 220
Y E KE+EI NLK N +AE +R +ID + +++
Sbjct: 970 EEEYKLE---KEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQD 1026
Query: 221 LRKEMEQKSDELKRVMLAQTQLIEQFNQ----SQEENTFLQETVRRECEERFELTEALS- 275
LRK K E +++ L Q E+FNQ Q+E +Q + EC R EL L+
Sbjct: 1027 LRK----KEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLAS 1082
Query: 276 ------QAREQLLELSKLRGSLPFSPCSLSKGSL 303
Q R +LL+LS F + G+L
Sbjct: 1083 KESDIEQLRAKLLDLSDSTSVASFPSADETDGNL 1116
Score = 47.8 bits (112), Expect = 2e-05
Identities = 55/305 (18%), Positives = 129/305 (42%), Gaps = 36/305 (11%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
KE +D L ++ L+ +L K K +++R+ NE ++TK L + + K
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKS---LQQRLEQEVNEHKVTKARLTDKHQSIEEAK 709
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL--AKERAQHLVEFEEQALLFK 121
+ + K + +E +++ + ++ +L ++++ +HL +E+ +
Sbjct: 710 SVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER---ME 766
Query: 122 EETK-LQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE------- 173
+E K L L +E+E ++ ++ + + + + + +D + G + ++QE+ TL E
Sbjct: 767 DEVKNLTLQLEQESNKRLLLQNELKTQAFE---ADNLKGLEKQMKQEINTLLEAKRLLEF 823
Query: 174 ------KLHKSHTRYTEE-----------SNSKEKEIENLKNLVAEFESRLKKEIDSNDS 216
K ++ + E S + +++ LK + E K+I +
Sbjct: 824 ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQN 883
Query: 217 VSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQ 276
E L +++ + + LA+ L EQ+ + +E+ R+E ++ L +
Sbjct: 884 EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE 943
Query: 277 AREQL 281
A L
Sbjct: 944 ANSML 948
Score = 47.4 bits (111), Expect = 2e-05
Identities = 54/241 (22%), Positives = 105/241 (43%), Gaps = 21/241 (8%)
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFEEQALL 119
T N + + S QK+I +L+E L ++ D ++K K ++ ++ E
Sbjct: 416 TSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRR 475
Query: 120 FKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSH 179
E T Q++ EK Q I +Y+++ E+ K R++ EV+TLK++L +
Sbjct: 476 NLESTVSQIEKEKMLLQHRINEYQRKAEQENEK--------RRNVENEVSTLKDQL-EDL 526
Query: 180 TRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQ 239
+ ++ S +++ L+ + E L+ E D+ + LRK + S +
Sbjct: 527 KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDT----AVRLRKSHTEMSKSI------- 575
Query: 240 TQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLS 299
+QL + QE N L+ + + ++ ++L L R S++ G L SL
Sbjct: 576 SQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQ 635
Query: 300 K 300
+
Sbjct: 636 E 636
Score = 46.6 bits (109), Expect = 4e-05
Identities = 71/317 (22%), Positives = 140/317 (44%), Gaps = 63/317 (19%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ +T +++ + +K + E E + + +LN + +E L+ + L S Q+ +EQ
Sbjct: 627 LQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQ 686
Query: 80 -------LQETLRQKLLSDDNWKEKIEAEL---------AKERAQH-LVEFEEQALLF-- 120
+ L K S + K E+ A+E+A++ +V+ E+Q +
Sbjct: 687 EVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDV 746
Query: 121 ---KEETKLQ-LDIEKEKHQDVIQKYKKEQEE-------LQMKI------SDLITGATRD 163
+ + KL+ L KE+ +D ++ + E+ LQ ++ +D + G +
Sbjct: 747 DLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQ 806
Query: 164 LRQEVTTL---KEKLHKSHTRYTEESNSKEKEIENLKN----------LVAEFESRLKKE 210
++QE+ TL K L + T++ E ++ L++ L LK+E
Sbjct: 807 MKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEE 866
Query: 211 IDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFEL 270
I+ + ENL+K E +++ K + Q L E +S++ L E E+ FEL
Sbjct: 867 IEEKN--RENLKKIQELQNE--KETLATQLDLAETKAESEQLARGLLE------EQYFEL 916
Query: 271 TE----ALSQAREQLLE 283
T+ A S+ R+++ +
Sbjct: 917 TQESKKAASRNRQEITD 933
Score = 45.8 bits (107), Expect = 7e-05
Identities = 64/290 (22%), Positives = 131/290 (45%), Gaps = 31/290 (10%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERE-LMLISHQKSIE 78
L+ ++ EK++ ++ RIN + + E EV TLK++ E L +S +
Sbjct: 477 LESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLA 536
Query: 79 QLQETLRQKLLSDDNWKEKIEAELA-------KERAQHLVEFE------EQALLFKEETK 125
+ + QK L + N + E++ A E ++ + + E ++ E +K
Sbjct: 537 NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596
Query: 126 LQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEE 185
Q D + + Q +++ ++++ I DL T L++EV LK L K E
Sbjct: 597 SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARIT-SLQEEVKHLKHNLEKVEGERKEA 655
Query: 186 S---NSKEKEIENLK----NLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLA 238
N EKE NL+ + + RL++E++ + V++ + Q +E K V +
Sbjct: 656 QDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEH-KVTKARLTDKHQSIEEAKSVAMC 714
Query: 239 QTQ-LIEQFNQSQE--ENTFLQETVRRECEERFELTEALSQAREQLLELS 285
+ + +++ +++E EN +Q + ++C L L Q++++L L+
Sbjct: 715 EMEKKLKEEREAREKAENRVVQ--IEKQCS---MLDVDLKQSQQKLEHLT 759
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 68.2 bits (165), Expect = 1e-11
Identities = 76/311 (24%), Positives = 150/311 (48%), Gaps = 41/311 (13%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENEL-EITKTL--LNQTRE 57
++L+EK Q+ + L EEL+ +Q + ++ I E++L E K+L + +
Sbjct: 518 LILEEK----CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 58 EVLTLKNERELMLISHQKSIE----QLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEF 113
E+++ R+ + + H+ + +L+ ++K D E EAEL + R Q L
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSH 633
Query: 114 EEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQ------------EELQMKISDLITGAT 161
EE+ KE+ +++ I EK +D + + K+Q E +Q + +LIT
Sbjct: 634 EEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT-KQ 692
Query: 162 RDLRQEVTTLKE----KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSV 217
L E++ LK+ ++ T + N +KEIE L+ E + L++E+
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE-KGTLEQEVQELQLK 751
Query: 218 SENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQA 277
+E L K+M++K ++L+ E+F Q + EN+ L++ ++ E+ ++ +SQ
Sbjct: 752 TELLEKQMKEKENDLQ----------EKFAQLEAENSILKDE-KKTLEDMLKIHTPVSQ- 799
Query: 278 REQLLELSKLR 288
E+L+ L ++
Sbjct: 800 EERLIFLDSIK 810
Score = 59.3 bits (142), Expect = 6e-09
Identities = 60/262 (22%), Positives = 119/262 (45%), Gaps = 34/262 (12%)
Query: 10 LMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELM 69
L + + +E T+ E+Q ++ I+ E EL L + E ++ ERE
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974
Query: 70 LISHQKSIEQLQE-TLRQKLLSDDN--WKEKIEAELAKERAQHLVEFEEQALLFKEETKL 126
L+S QK + + + Q+LL + KEK+E + E+ + ++ K+ L
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ--------KQVKAL 2026
Query: 127 QLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEES 186
++D+E++ + + + +K E + DLRQ+ L+++L K E++
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELM-------------DLRQQNQALEKQLEKMRKFLDEQA 2073
Query: 187 NSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQ-------KSDELKRVMLAQ 239
+E E + + + + E +L K + +SE+ +E+EQ K+D+ ++L++
Sbjct: 2074 IDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
Query: 240 TQLIEQFNQSQEENTFLQETVR 261
QL + EE L+ VR
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVR 2154
Score = 58.2 bits (139), Expect = 1e-08
Identities = 68/290 (23%), Positives = 136/290 (46%), Gaps = 30/290 (10%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTL--LNQTREEVLTLKNEREL---MLISHQ 74
++ EL K+ + E++ R + E+ +T L Q +E +K + + + Q
Sbjct: 160 MESELAGKQHEIEELNRELE----EMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215
Query: 75 KSIEQLQETLRQKL-LSDDNWKEKIEAEL--AKERAQHLVEFEEQALLFKEETKLQLDIE 131
++ + ET+R+ L L++ + K +I+ + A E ++ A L + + ++ +
Sbjct: 216 QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ 275
Query: 132 KEKHQD-VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLK-EKLHKSHTRYTEESNSK 189
+ + QD +++ Y+K++E+ M+IS L ++++ + E+ K EE K
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFL--------QEKIKVYEMEQDKKVENSNKEEIQEK 327
Query: 190 EKEIENLKNLVAEFESR---LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQF 246
E IE L + E E + LK ++ + D + L++++ QK+ E+K + L T ++
Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387
Query: 247 NQSQEENTFLQETV-----RRECEERFELTEALSQAREQLLELSKLRGSL 291
QS EE L TV R + +FE +E +L +LR L
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Score = 56.6 bits (135), Expect = 4e-08
Identities = 72/314 (22%), Positives = 139/314 (44%), Gaps = 43/314 (13%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKN 64
E +D L T ++ LQE++ K ++ +++K EL +K Q+ EE+ L
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKL-------ELTNSKQKERQSSEEIKQLMG 399
Query: 65 E-RELMLISHQKSIEQLQETLRQKLLSDDNWK-EKIEAELAKERAQHLVEFEEQALLFKE 122
EL +H+ S Q + + Q++ + K E++ AEL + Q +V+ +++ +
Sbjct: 400 TVEELQKRNHKDS--QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI---R 454
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEEL-----QMKISDLITGATRDLRQEVTTLKEKLHK 177
+ Q++ K +H+ ++ + + Q+K+ ++ Q+ + KEKL +
Sbjct: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
Query: 178 SHTRYTEESNSKEKEIENL--------------KNLVAEFESRLKKEIDSNDSVSENLRK 223
EE + ++++E+L + +AE ES+L E + S E+L+
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKA 573
Query: 224 EMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEA-LSQAREQLL 282
E+ S+ K + L + + E L++ + E EA L + R QLL
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLE---MLEKEKNAVLDRMAESQEAELERLRTQLL 630
Query: 283 -----ELSKLRGSL 291
ELSKL+ L
Sbjct: 631 FSHEEELSKLKEDL 644
Score = 54.3 bits (129), Expect = 2e-07
Identities = 58/267 (21%), Positives = 124/267 (46%), Gaps = 9/267 (3%)
Query: 28 EKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQK 87
E Q + + I+ E E+ + L Q REE L KNE E+ + Q I++ + T R +
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNE-EVQQLHMQLEIQKKESTTRLQ 2245
Query: 88 LLSDDN--WKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKE 145
L +N +K+ +E + + ++Q +LF + ++ + E E Q + ++ K
Sbjct: 2246 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ-LNEQVTKL 2304
Query: 146 QEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFES 205
Q++L++ + + +L +++ T E L ++E+EIE L ++ + +
Sbjct: 2305 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV---KRNREEEIEQLNEVIEKLQQ 2361
Query: 206 RLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE 265
L + +L +E + +L V+ + L +Q + EE TF++ ++
Sbjct: 2362 ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
Query: 266 ERFELTEALSQAREQLLELSKLRGSLP 292
+ +LT+ L + + + K++ S+P
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQ-SIP 2447
Score = 46.2 bits (108), Expect = 5e-05
Identities = 72/327 (22%), Positives = 131/327 (40%), Gaps = 72/327 (22%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL 80
Q + E+Q ED ++ L E + + L ++ + L +ERE +L+ ++++QL
Sbjct: 1610 QAHMRQMERQREDQEQ---LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
Query: 81 QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKE---KHQD 137
R+KL + + + + ++ E EEQ KE + D+ E +
Sbjct: 1667 SLAGREKLCCE----LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERY 1722
Query: 138 VIQKYKKEQEELQMKISDLITGATRDLRQEV-----------------------TTLKEK 174
+QK ++ +++ + + V ++K
Sbjct: 1723 ALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC 1782
Query: 175 LHKSHTRYTEES------NSKEKEIENLKNLVAEFESRLKK----------EIDSND--- 215
+H+ HTR T+ES + + N+ + V E + L + EID +
Sbjct: 1783 VHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
Query: 216 ---------SVSENLRKEMEQKSDELKRVMLAQTQLI-EQFNQSQE--ENTFLQETVRRE 263
+ E L + + + S +L+ + QT+L+ E F Q QE E+ QE +R
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
Query: 264 CEERFELTEALSQAREQL-LELSKLRG 289
E S+AREQL +ELSK G
Sbjct: 1903 LHEE-------SRAREQLAVELSKAEG 1922
Score = 44.3 bits (103), Expect = 2e-04
Identities = 68/327 (20%), Positives = 144/327 (44%), Gaps = 50/327 (15%)
Query: 3 LKEKEDSLMTCQQI--YKALQEELTVKEKQEE--DIKRRINLAENELEITKTLLNQTREE 58
LK +++S Q++ Y Q++ + E Q E +K R + +L K ++ + + E
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
Query: 59 VLTLKNERELMLISHQKSIEQLQ-----------------ETL--RQKLLSDDNW---KE 96
+ K E E L + K +++L+ +TL QK + W KE
Sbjct: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3227
Query: 97 KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKI-SD 155
K + ++ER + +E + +L +++ LQL++ E+ + ++ + +++ E +M +
Sbjct: 3228 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQ 3287
Query: 156 LITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSND 215
L R+L +V EK+ R E S++ ++E E L + + + ++
Sbjct: 3288 LSEEQGRNLELQVLLESEKV-----RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3342
Query: 216 SVSENLRKEMEQKS-------DELKRVMLAQTQLIEQFNQ-----------SQEENTFLQ 257
+ + L+K++E+K +E ++ L Q +Q + QE NT Q
Sbjct: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3402
Query: 258 ETVRRECEERFELTEALSQAREQLLEL 284
+ + + +L L + R+Q+ +L
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKL 3429
Score = 36.2 bits (82), Expect = 0.052
Identities = 60/272 (22%), Positives = 114/272 (41%), Gaps = 40/272 (14%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE--------RELMLI 71
L E+L V ++++ ++ +R++ +L+ ++ EEV +LK E REL +I
Sbjct: 941 LMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEII 1000
Query: 72 SHQKSIEQLQ--ETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLD 129
+ E +Q +T LL + A+ V ++ F EE+K+ ++
Sbjct: 1001 INHNRAENVQSCDTQVSSLLDG-------VVTMTSRGAEGSVSKVNKS--FGEESKIMVE 1051
Query: 130 IEKEKHQDVIQKYKKEQEELQMKISDLITGATRD--LRQEVTTLKEKLHKSHTRYTEESN 187
+K +++ + +QE+L I D + T++ LR + +KL K E N
Sbjct: 1052 -DKVSFENMTVGEESKQEQL---ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 188 SKEKEIENLK---NLVAEFESRLKKEIDSND------SVSENLRKEMEQKSDELKRVMLA 238
++E + +LV +E N+ S+ E L E+K EL+++
Sbjct: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
Query: 239 QTQLIEQFNQSQEENTF------LQETVRREC 264
+ Q ++ E LQ+ V EC
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEEC 1199
Score = 35.4 bits (80), Expect = 0.088
Identities = 53/274 (19%), Positives = 120/274 (43%), Gaps = 44/274 (16%)
Query: 20 LQEELTVKEKQEEDIKRRINLAEN--------------ELEIT------KTLLNQT---- 55
L +EL +++ E +++ ++ EN ELE+ K+L NQT
Sbjct: 2426 LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2485
Query: 56 -----REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHL 110
+ ++ L E L+ + S + L+ T K + D + + E E+ +++ +L
Sbjct: 2486 FEENGKGSIINL--ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
Query: 111 VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
+ E+ + +++QL+ +E + E + I +L +L +++
Sbjct: 2544 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA 2603
Query: 171 LKEKLHKSHTRYTEESNS---KEKEIENLKNLVAEFESR---LKKEIDSNDSVSENLRKE 224
L ++ + ++ E S +++++E + V E E + L+K ++ N+ + R++
Sbjct: 2604 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE---KKQREK 2660
Query: 225 MEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQE 258
+++S + V+ T+L S EE+ F E
Sbjct: 2661 EKKRSPQDVEVLKTTTELF----HSNEESGFFNE 2690
Score = 34.3 bits (77), Expect = 0.20
Identities = 46/230 (20%), Positives = 100/230 (43%), Gaps = 15/230 (6%)
Query: 70 LISHQKSIEQLQE---TLRQKLLSDDNWKEKIEAELAKERAQHL----VEFEEQALLFKE 122
L ++ ++ QE TL K+ + N ++ L+K Q +EF E+ L +E
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
L + + +D+ +K + LQ + ++L +++L+++L ++ Y
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Query: 183 TEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQL 242
E + +K ++ V+E +DS + ++ M S +K+ + +
Sbjct: 1362 EAEIHCLQKRLQ----AVSESTVPPSLPVDSVVITESDAQRTMYPGSC-VKKNIDGTIEF 1416
Query: 243 IEQFNQSQEEN--TFLQETVRRECEERF-ELTEALSQAREQLLELSKLRG 289
+F +E N L++ + + EE ++ ++S A Q ELS++ G
Sbjct: 1417 SGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Score = 34.3 bits (77), Expect = 0.20
Identities = 56/258 (21%), Positives = 105/258 (40%), Gaps = 57/258 (22%)
Query: 4 KEKEDSLMTCQQIYKALQ---EELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
K K DSL T QQ+ K Q + L +++ + +++++ ++++E + L + R++V
Sbjct: 3368 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3427
Query: 61 TL-----------------KNERELMLISHQKSIEQLQETLRQKLLSDD--NW--KEKIE 99
L + ERE S + + L E L SD NW ++KIE
Sbjct: 3428 KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
Query: 100 AELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYK----KEQEELQMKISD 155
E + L+E E L++ ++K Q V K + K E LQ + +D
Sbjct: 3488 GETKESNYAKLIEMNGGGTGCNHE----LEMIRQKLQCVASKLQVLPQKASERLQFETAD 3543
Query: 156 -------------------LITGATRDLRQEVT------TLKEKLHKSHTRYTEESNSKE 190
+TG + V+ +L E+L + + T +
Sbjct: 3544 DEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLT 3603
Query: 191 KEIENLKNLVAEFESRLK 208
+E +L+N+V + E +++
Sbjct: 3604 EEKNDLRNMVMKLEEQIR 3621
Score = 33.5 bits (75), Expect = 0.33
Identities = 57/316 (18%), Positives = 125/316 (39%), Gaps = 52/316 (16%)
Query: 17 YKALQEELTV-----------KEKQEEDIKRRINLAENELEITK----------TLLNQT 55
Y+ LQEE K KQE + K ++ EL + + ++ ++
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
+ V E++ + +E+L+ T R+KL + +E K++ + E
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDL--SEQLKQKHGEISFLNE 978
Query: 116 QALLFKEETKLQLDIEKEKHQDVIQKYKKEQ-EELQMKISDLITGATRDLRQEVTTLKEK 174
+ K+E K Q+ + + + +I + E + ++S L+ G + K
Sbjct: 979 EVKSLKQE-KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSK 1037
Query: 175 LHKS----------------HTRYTEESNSKEKEIENLKNLVAEFESR---------LKK 209
++KS + EES ++ +++L ++ E R L+K
Sbjct: 1038 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097
Query: 210 EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTF--LQETVRRECEER 267
E++ S +LR +ME + L V + ++ +++++ L+E + EE+
Sbjct: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157
Query: 268 FELTEALSQAREQLLE 283
+ + + Q Q ++
Sbjct: 1158 IKELQKIHQLELQTMK 1173
Score = 33.1 bits (74), Expect = 0.44
Identities = 45/208 (21%), Positives = 95/208 (45%), Gaps = 22/208 (10%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQEEL VKE +++ ++ + L K L+ +L ++E E+ E
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS-----ILEKEDETEVQESKKACMFEP 2769
Query: 80 LQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVI 139
L L + + S + KI + + + Q LV+ + LQ + E+ ++I
Sbjct: 2770 LPIKLSKSIASQTDGTLKISS--SNQTPQILVKNA------GIQINLQSECSSEEVTEII 2821
Query: 140 QKYKKEQEELQ-MKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN 198
++ ++ E++Q + ++++ +R + E TLK + + + EE + + I+ L++
Sbjct: 2822 SQFTEKIEKMQELHAAEILDMESRHI-SETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
Query: 199 L-------VAEFESRLKKEIDSNDSVSE 219
+A ++ +EI S+DS S+
Sbjct: 2881 KEGSSIPELAHSDAYQTREICSSDSGSD 2908
Score = 32.0 bits (71), Expect = 0.97
Identities = 62/306 (20%), Positives = 130/306 (42%), Gaps = 76/306 (24%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
M L + + T + + +EE K+ + + I L+ ++ + ++++ VL
Sbjct: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHD----IPESKDCVL 1546
Query: 61 TLKNE---RELMLISHQKSIEQLQ----ETLRQKLLSDDNWKEKIEAELAKERAQHLVEF 113
T+ E ++ I Q +++ + RQ +L+++ E + EL ++ +H
Sbjct: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQL-EDMRQELVRQYQEH---- 1601
Query: 114 EEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE 173
+QA ++ ++ H +++ +++QE+LQ +E+ L
Sbjct: 1602 -QQAT----------ELLRQAHMRQMERQREDQEQLQ---------------EEIKRLNR 1635
Query: 174 KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVS----ENLRKEMEQKS 229
+L ++ I+N +NLV+E E L +E+++ +S E L E+ S
Sbjct: 1636 QL------------AQRSSIDN-ENLVSERERVLLEELEALKQLSLAGREKLCCELRNSS 1682
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE---------ERFELTEALSQAREQ 280
QTQ + EE TF ++ + R+ E ER+ L +A ++ +
Sbjct: 1683 --------TQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKI 1734
Query: 281 LLELSK 286
LLE+ K
Sbjct: 1735 LLEVVK 1740
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 68.2 bits (165), Expect = 1e-11
Identities = 76/311 (24%), Positives = 150/311 (48%), Gaps = 41/311 (13%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENEL-EITKTL--LNQTRE 57
++L+EK Q+ + L EEL+ +Q + ++ I E++L E K+L + +
Sbjct: 518 LILEEK----CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 58 EVLTLKNERELMLISHQKSIE----QLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEF 113
E+++ R+ + + H+ + +L+ ++K D E EAEL + R Q L
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSH 633
Query: 114 EEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQ------------EELQMKISDLITGAT 161
EE+ KE+ +++ I EK +D + + K+Q E +Q + +LIT
Sbjct: 634 EEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT-KQ 692
Query: 162 RDLRQEVTTLKE----KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSV 217
L E++ LK+ ++ T + N +KEIE L+ E + L++E+
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE-KGTLEQEVQELQLK 751
Query: 218 SENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQA 277
+E L K+M++K ++L+ E+F Q + EN+ L++ ++ E+ ++ +SQ
Sbjct: 752 TELLEKQMKEKENDLQ----------EKFAQLEAENSILKDE-KKTLEDMLKIHTPVSQ- 799
Query: 278 REQLLELSKLR 288
E+L+ L ++
Sbjct: 800 EERLIFLDSIK 810
Score = 59.3 bits (142), Expect = 6e-09
Identities = 60/262 (22%), Positives = 119/262 (45%), Gaps = 34/262 (12%)
Query: 10 LMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELM 69
L + + +E T+ E+Q ++ I+ E EL L + E ++ ERE
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-- 1974
Query: 70 LISHQKSIEQLQE-TLRQKLLSDDN--WKEKIEAELAKERAQHLVEFEEQALLFKEETKL 126
L+S QK + + + Q+LL + KEK+E + E+ + ++ K+ L
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ--------KQVKAL 2026
Query: 127 QLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEES 186
++D+E++ + + + +K E + DLRQ+ L+++L K E++
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELM-------------DLRQQNQALEKQLEKMRKFLDEQA 2073
Query: 187 NSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQ-------KSDELKRVMLAQ 239
+E E + + + + E +L K + +SE+ +E+EQ K+D+ ++L++
Sbjct: 2074 IDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
Query: 240 TQLIEQFNQSQEENTFLQETVR 261
QL + EE L+ VR
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVR 2154
Score = 58.2 bits (139), Expect = 1e-08
Identities = 68/290 (23%), Positives = 136/290 (46%), Gaps = 30/290 (10%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTL--LNQTREEVLTLKNEREL---MLISHQ 74
++ EL K+ + E++ R + E+ +T L Q +E +K + + + Q
Sbjct: 160 MESELAGKQHEIEELNRELE----EMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215
Query: 75 KSIEQLQETLRQKL-LSDDNWKEKIEAEL--AKERAQHLVEFEEQALLFKEETKLQLDIE 131
++ + ET+R+ L L++ + K +I+ + A E ++ A L + + ++ +
Sbjct: 216 QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ 275
Query: 132 KEKHQD-VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLK-EKLHKSHTRYTEESNSK 189
+ + QD +++ Y+K++E+ M+IS L ++++ + E+ K EE K
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFL--------QEKIKVYEMEQDKKVENSNKEEIQEK 327
Query: 190 EKEIENLKNLVAEFESR---LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQF 246
E IE L + E E + LK ++ + D + L++++ QK+ E+K + L T ++
Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387
Query: 247 NQSQEENTFLQETV-----RRECEERFELTEALSQAREQLLELSKLRGSL 291
QS EE L TV R + +FE +E +L +LR L
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Score = 56.6 bits (135), Expect = 4e-08
Identities = 72/314 (22%), Positives = 139/314 (44%), Gaps = 43/314 (13%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKN 64
E +D L T ++ LQE++ K ++ +++K EL +K Q+ EE+ L
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKL-------ELTNSKQKERQSSEEIKQLMG 399
Query: 65 E-RELMLISHQKSIEQLQETLRQKLLSDDNWK-EKIEAELAKERAQHLVEFEEQALLFKE 122
EL +H+ S Q + + Q++ + K E++ AEL + Q +V+ +++ +
Sbjct: 400 TVEELQKRNHKDS--QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI---R 454
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEEL-----QMKISDLITGATRDLRQEVTTLKEKLHK 177
+ Q++ K +H+ ++ + + Q+K+ ++ Q+ + KEKL +
Sbjct: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
Query: 178 SHTRYTEESNSKEKEIENL--------------KNLVAEFESRLKKEIDSNDSVSENLRK 223
EE + ++++E+L + +AE ES+L E + S E+L+
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKA 573
Query: 224 EMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEA-LSQAREQLL 282
E+ S+ K + L + + E L++ + E EA L + R QLL
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLE---MLEKEKNAVLDRMAESQEAELERLRTQLL 630
Query: 283 -----ELSKLRGSL 291
ELSKL+ L
Sbjct: 631 FSHEEELSKLKEDL 644
Score = 55.5 bits (132), Expect = 8e-08
Identities = 67/327 (20%), Positives = 147/327 (44%), Gaps = 42/327 (12%)
Query: 3 LKEKEDS----LMTCQQIYKALQE--------ELTVKEKQEE---DIKRRINLAENELEI 47
LKEK D L++ +Q+ + +QE E V+E ++ + ++ E + E+
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL 2177
Query: 48 TKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERA 107
+ + Q + + K E+E+ + Q +EQ +E L K ++E + KE
Sbjct: 2178 SLEVQLQAERDAIDRK-EKEITNLEEQ--LEQFREELENKNEEVQQLHMQLEIQ-KKEST 2233
Query: 108 QHLVEFEEQALLFKEET-KLQLDIEKE-------------KHQDVIQKYKKEQEELQMKI 153
L E E++ LFK++ KL L I++ K +IQ+ + E ++L ++
Sbjct: 2234 TRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2293
Query: 154 SDL-----ITGATRDLRQEVTTLKEKLHKSHTRYTEES---NSKEKEIENLKNLVAEFES 205
+ L IT + + ++ +++ + +++ ++E+EIE L ++ + +
Sbjct: 2294 TKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2353
Query: 206 RLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE 265
L + +L +E + +L V+ + L +Q + EE TF++ ++
Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2413
Query: 266 ERFELTEALSQAREQLLELSKLRGSLP 292
+ +LT+ L + + + K++ S+P
Sbjct: 2414 KMNQLTQELFSLKRERESVEKIQ-SIP 2439
Score = 46.2 bits (108), Expect = 5e-05
Identities = 72/327 (22%), Positives = 131/327 (40%), Gaps = 72/327 (22%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL 80
Q + E+Q ED ++ L E + + L ++ + L +ERE +L+ ++++QL
Sbjct: 1610 QAHMRQMERQREDQEQ---LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
Query: 81 QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKE---KHQD 137
R+KL + + + + ++ E EEQ KE + D+ E +
Sbjct: 1667 SLAGREKLCCE----LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERY 1722
Query: 138 VIQKYKKEQEELQMKISDLITGATRDLRQEV-----------------------TTLKEK 174
+QK ++ +++ + + V ++K
Sbjct: 1723 ALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC 1782
Query: 175 LHKSHTRYTEES------NSKEKEIENLKNLVAEFESRLKK----------EIDSND--- 215
+H+ HTR T+ES + + N+ + V E + L + EID +
Sbjct: 1783 VHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
Query: 216 ---------SVSENLRKEMEQKSDELKRVMLAQTQLI-EQFNQSQE--ENTFLQETVRRE 263
+ E L + + + S +L+ + QT+L+ E F Q QE E+ QE +R
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
Query: 264 CEERFELTEALSQAREQL-LELSKLRG 289
E S+AREQL +ELSK G
Sbjct: 1903 LHEE-------SRAREQLAVELSKAEG 1922
Score = 44.3 bits (103), Expect = 2e-04
Identities = 68/327 (20%), Positives = 144/327 (44%), Gaps = 50/327 (15%)
Query: 3 LKEKEDSLMTCQQI--YKALQEELTVKEKQEE--DIKRRINLAENELEITKTLLNQTREE 58
LK +++S Q++ Y Q++ + E Q E +K R + +L K ++ + + E
Sbjct: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3159
Query: 59 VLTLKNERELMLISHQKSIEQLQ-----------------ETL--RQKLLSDDNW---KE 96
+ K E E L + K +++L+ +TL QK + W KE
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3219
Query: 97 KIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKI-SD 155
K + ++ER + +E + +L +++ LQL++ E+ + ++ + +++ E +M +
Sbjct: 3220 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQ 3279
Query: 156 LITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSND 215
L R+L +V EK+ R E S++ ++E E L + + + ++
Sbjct: 3280 LSEEQGRNLELQVLLESEKV-----RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3334
Query: 216 SVSENLRKEMEQKS-------DELKRVMLAQTQLIEQFNQ-----------SQEENTFLQ 257
+ + L+K++E+K +E ++ L Q +Q + QE NT Q
Sbjct: 3335 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3394
Query: 258 ETVRRECEERFELTEALSQAREQLLEL 284
+ + + +L L + R+Q+ +L
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKL 3421
Score = 36.2 bits (82), Expect = 0.052
Identities = 60/272 (22%), Positives = 114/272 (41%), Gaps = 40/272 (14%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE--------RELMLI 71
L E+L V ++++ ++ +R++ +L+ ++ EEV +LK E REL +I
Sbjct: 941 LMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEII 1000
Query: 72 SHQKSIEQLQ--ETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLD 129
+ E +Q +T LL + A+ V ++ F EE+K+ ++
Sbjct: 1001 INHNRAENVQSCDTQVSSLLDG-------VVTMTSRGAEGSVSKVNKS--FGEESKIMVE 1051
Query: 130 IEKEKHQDVIQKYKKEQEELQMKISDLITGATRD--LRQEVTTLKEKLHKSHTRYTEESN 187
+K +++ + +QE+L I D + T++ LR + +KL K E N
Sbjct: 1052 -DKVSFENMTVGEESKQEQL---ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 188 SKEKEIENLK---NLVAEFESRLKKEIDSND------SVSENLRKEMEQKSDELKRVMLA 238
++E + +LV +E N+ S+ E L E+K EL+++
Sbjct: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
Query: 239 QTQLIEQFNQSQEENTF------LQETVRREC 264
+ Q ++ E LQ+ V EC
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEEC 1199
Score = 35.4 bits (80), Expect = 0.088
Identities = 53/274 (19%), Positives = 120/274 (43%), Gaps = 44/274 (16%)
Query: 20 LQEELTVKEKQEEDIKRRINLAEN--------------ELEIT------KTLLNQT---- 55
L +EL +++ E +++ ++ EN ELE+ K+L NQT
Sbjct: 2418 LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2477
Query: 56 -----REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHL 110
+ ++ L E L+ + S + L+ T K + D + + E E+ +++ +L
Sbjct: 2478 FEENGKGSIINL--ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535
Query: 111 VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
+ E+ + +++QL+ +E + E + I +L +L +++
Sbjct: 2536 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA 2595
Query: 171 LKEKLHKSHTRYTEESNS---KEKEIENLKNLVAEFESR---LKKEIDSNDSVSENLRKE 224
L ++ + ++ E S +++++E + V E E + L+K ++ N+ + R++
Sbjct: 2596 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE---KKQREK 2652
Query: 225 MEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQE 258
+++S + V+ T+L S EE+ F E
Sbjct: 2653 EKKRSPQDVEVLKTTTELF----HSNEESGFFNE 2682
Score = 34.3 bits (77), Expect = 0.20
Identities = 46/230 (20%), Positives = 100/230 (43%), Gaps = 15/230 (6%)
Query: 70 LISHQKSIEQLQE---TLRQKLLSDDNWKEKIEAELAKERAQHL----VEFEEQALLFKE 122
L ++ ++ QE TL K+ + N ++ L+K Q +EF E+ L +E
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
L + + +D+ +K + LQ + ++L +++L+++L ++ Y
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Query: 183 TEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQL 242
E + +K ++ V+E +DS + ++ M S +K+ + +
Sbjct: 1362 EAEIHCLQKRLQ----AVSESTVPPSLPVDSVVITESDAQRTMYPGSC-VKKNIDGTIEF 1416
Query: 243 IEQFNQSQEEN--TFLQETVRRECEERF-ELTEALSQAREQLLELSKLRG 289
+F +E N L++ + + EE ++ ++S A Q ELS++ G
Sbjct: 1417 SGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Score = 34.3 bits (77), Expect = 0.20
Identities = 56/258 (21%), Positives = 105/258 (40%), Gaps = 57/258 (22%)
Query: 4 KEKEDSLMTCQQIYKALQ---EELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
K K DSL T QQ+ K Q + L +++ + +++++ ++++E + L + R++V
Sbjct: 3360 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3419
Query: 61 TL-----------------KNERELMLISHQKSIEQLQETLRQKLLSDD--NW--KEKIE 99
L + ERE S + + L E L SD NW ++KIE
Sbjct: 3420 KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3479
Query: 100 AELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYK----KEQEELQMKISD 155
E + L+E E L++ ++K Q V K + K E LQ + +D
Sbjct: 3480 GETKESNYAKLIEMNGGGTGCNHE----LEMIRQKLQCVASKLQVLPQKASERLQFETAD 3535
Query: 156 -------------------LITGATRDLRQEVT------TLKEKLHKSHTRYTEESNSKE 190
+TG + V+ +L E+L + + T +
Sbjct: 3536 DEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLT 3595
Query: 191 KEIENLKNLVAEFESRLK 208
+E +L+N+V + E +++
Sbjct: 3596 EEKNDLRNMVMKLEEQIR 3613
Score = 33.5 bits (75), Expect = 0.33
Identities = 57/316 (18%), Positives = 125/316 (39%), Gaps = 52/316 (16%)
Query: 17 YKALQEELTV-----------KEKQEEDIKRRINLAENELEITK----------TLLNQT 55
Y+ LQEE K KQE + K ++ EL + + ++ ++
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 56 REEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
+ V E++ + +E+L+ T R+KL + +E K++ + E
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDL--SEQLKQKHGEISFLNE 978
Query: 116 QALLFKEETKLQLDIEKEKHQDVIQKYKKEQ-EELQMKISDLITGATRDLRQEVTTLKEK 174
+ K+E K Q+ + + + +I + E + ++S L+ G + K
Sbjct: 979 EVKSLKQE-KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSK 1037
Query: 175 LHKS----------------HTRYTEESNSKEKEIENLKNLVAEFESR---------LKK 209
++KS + EES ++ +++L ++ E R L+K
Sbjct: 1038 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097
Query: 210 EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTF--LQETVRRECEER 267
E++ S +LR +ME + L V + ++ +++++ L+E + EE+
Sbjct: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157
Query: 268 FELTEALSQAREQLLE 283
+ + + Q Q ++
Sbjct: 1158 IKELQKIHQLELQTMK 1173
Score = 33.1 bits (74), Expect = 0.44
Identities = 45/208 (21%), Positives = 95/208 (45%), Gaps = 22/208 (10%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQEEL VKE +++ ++ + L K L+ +L ++E E+ E
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS-----ILEKEDETEVQESKKACMFEP 2761
Query: 80 LQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVI 139
L L + + S + KI + + + Q LV+ + LQ + E+ ++I
Sbjct: 2762 LPIKLSKSIASQTDGTLKISS--SNQTPQILVKNA------GIQINLQSECSSEEVTEII 2813
Query: 140 QKYKKEQEELQ-MKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN 198
++ ++ E++Q + ++++ +R + E TLK + + + EE + + I+ L++
Sbjct: 2814 SQFTEKIEKMQELHAAEILDMESRHI-SETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2872
Query: 199 L-------VAEFESRLKKEIDSNDSVSE 219
+A ++ +EI S+DS S+
Sbjct: 2873 KEGSSIPELAHSDAYQTREICSSDSGSD 2900
Score = 32.0 bits (71), Expect = 0.97
Identities = 62/306 (20%), Positives = 130/306 (42%), Gaps = 76/306 (24%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
M L + + T + + +EE K+ + + I L+ ++ + ++++ VL
Sbjct: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHD----IPESKDCVL 1546
Query: 61 TLKNE---RELMLISHQKSIEQLQ----ETLRQKLLSDDNWKEKIEAELAKERAQHLVEF 113
T+ E ++ I Q +++ + RQ +L+++ E + EL ++ +H
Sbjct: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQL-EDMRQELVRQYQEH---- 1601
Query: 114 EEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE 173
+QA ++ ++ H +++ +++QE+LQ +E+ L
Sbjct: 1602 -QQAT----------ELLRQAHMRQMERQREDQEQLQ---------------EEIKRLNR 1635
Query: 174 KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVS----ENLRKEMEQKS 229
+L ++ I+N +NLV+E E L +E+++ +S E L E+ S
Sbjct: 1636 QL------------AQRSSIDN-ENLVSERERVLLEELEALKQLSLAGREKLCCELRNSS 1682
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECE---------ERFELTEALSQAREQ 280
QTQ + EE TF ++ + R+ E ER+ L +A ++ +
Sbjct: 1683 --------TQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKI 1734
Query: 281 LLELSK 286
LLE+ K
Sbjct: 1735 LLEVVK 1740
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 68.2 bits (165), Expect = 1e-11
Identities = 78/302 (25%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
LKEK D +++ +Q +L+E + + KQ ED+ + L E E E +N+ RE L
Sbjct: 175 LKEKNDEILSLKQ---SLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNENL 228
Query: 63 KNERELMLISHQKSI--EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQAL-- 118
E + + QK I +Q +E L+QK L D+ ++ E EL+ Q L F+E+ +
Sbjct: 229 NAEMQNL---KQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQEEMVKE 284
Query: 119 --LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEK-- 174
LF+EE K LD D +Q+ +++ E L ++ + +L+ LK K
Sbjct: 285 KNLFEEELKQTLD-----ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 339
Query: 175 -LHKSHTRYTEES----NSKEKEIENLKNLVAEFES---RLKKEID----SNDSVSENLR 222
L KS +T+ + + +++L+++ A+FES EI+ N S+ E
Sbjct: 340 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 399
Query: 223 KEMEQKSDELKRVMLAQTQLIEQFNQ--SQEENTFLQETVRRECEERF--ELTEALSQAR 278
K + D +++ ++ E + + L+ET +E F ++T+ +Q +
Sbjct: 400 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 459
Query: 279 EQ 280
+Q
Sbjct: 460 QQ 461
Score = 46.2 bits (108), Expect = 5e-05
Identities = 55/259 (21%), Positives = 122/259 (47%), Gaps = 18/259 (6%)
Query: 30 QEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLL 89
++E ++ ++ + + LE ++ + Q ++++++ E+ I + E+L E + +
Sbjct: 101 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK----IDEKSETEKLLEYIEEISC 156
Query: 90 SDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDV---IQKYKKEQ 146
+ D EK + ++A + ++L E ++ L K+ + + I ++ +D+ Q +KE+
Sbjct: 157 ASDQ-VEKYKLDIA-QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 214
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+ + + +L E+ LK+K E+ KE +I++L E S
Sbjct: 215 EDHVNRNRE----HNENLNAEMQNLKQKFILEQQE-REKLQQKELQIDSLLQQEKELSSS 269
Query: 207 LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE 266
L +++ S E + KE +ELK+ + +L ++ Q++ L+E + EE
Sbjct: 270 LHQKLCS---FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE 326
Query: 267 RFELTEALSQAREQLLELS 285
+L E + +E LE S
Sbjct: 327 -LKLLEEKLKGKEAELEKS 344
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 51/257 (19%)
Query: 1 MLLKEKEDSLM------TCQ-QIYKAL---------------QEELTVKEKQEEDIKRRI 38
+LL+EK DS++ T Q + YKAL QE+ K ED++ +I
Sbjct: 353 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 412
Query: 39 NLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKI 98
E+ + +L + + + E + + +S + I LQ L+Q+ ++++++++
Sbjct: 413 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ---EEDFRKQL 469
Query: 99 E------AELAKERAQHLVEFEEQALLFKE---ETK---LQLDIEKEKHQDVIQKYKKEQ 146
E AE A+ E + LL++E +TK LQLD + + Q ++ ++ Q
Sbjct: 470 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 529
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+L KI D LK+K+ H ++ NS+ LK+ V++ +
Sbjct: 530 EQLN-KIRDSYAKLLGH-----QNLKQKI--KHVVKLKDENSQ------LKSEVSKLRCQ 575
Query: 207 LKKEIDSNDSVSENLRK 223
L K+ S + E L K
Sbjct: 576 LAKKKQSETKLQEELNK 592
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 68.2 bits (165), Expect = 1e-11
Identities = 78/302 (25%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
LKEK D +++ +Q +L+E + + KQ ED+ + L E E E +N+ RE L
Sbjct: 262 LKEKNDEILSLKQ---SLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNENL 315
Query: 63 KNERELMLISHQKSI--EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQAL-- 118
E + + QK I +Q +E L+QK L D+ ++ E EL+ Q L F+E+ +
Sbjct: 316 NAEMQNL---KQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQEEMVKE 371
Query: 119 --LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEK-- 174
LF+EE K LD D +Q+ +++ E L ++ + +L+ LK K
Sbjct: 372 KNLFEEELKQTLD-----ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 426
Query: 175 -LHKSHTRYTEES----NSKEKEIENLKNLVAEFES---RLKKEID----SNDSVSENLR 222
L KS +T+ + + +++L+++ A+FES EI+ N S+ E
Sbjct: 427 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 486
Query: 223 KEMEQKSDELKRVMLAQTQLIEQFNQ--SQEENTFLQETVRRECEERF--ELTEALSQAR 278
K + D +++ ++ E + + L+ET +E F ++T+ +Q +
Sbjct: 487 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 546
Query: 279 EQ 280
+Q
Sbjct: 547 QQ 548
Score = 56.2 bits (134), Expect = 5e-08
Identities = 70/295 (23%), Positives = 123/295 (41%), Gaps = 26/295 (8%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
K L++E+ V ++ RRI E ELE + LN E +L + L +
Sbjct: 86 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL-SANNATLEKQLIEL 144
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
+ E L+ K + N K ++ E L K ETK++ + K++ +
Sbjct: 145 TRTNELLKSKFSENGNQKN-----------LRILSLELMKLRNKRETKMRGMMAKQEGME 193
Query: 138 V-IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENL 196
+ +Q ++ EE Q KI+ L G + +E K + K Y EE + ++E
Sbjct: 194 MKLQVTQRSLEESQGKIAQL-EGKLVSIEKEKIDEKSETEKL-LEYIEEISCASDQVEKY 251
Query: 197 KNLVAEFESRLKKEIDS----NDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEE 252
K +A+ E LK++ D S+ EN+ +Q D + L + + + N+++E
Sbjct: 252 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 311
Query: 253 NTFLQETVRR-------ECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300
N L ++ E +ER +L + Q L + +L SL CS +
Sbjct: 312 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 366
Score = 46.2 bits (108), Expect = 5e-05
Identities = 55/259 (21%), Positives = 122/259 (47%), Gaps = 18/259 (6%)
Query: 30 QEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLL 89
++E ++ ++ + + LE ++ + Q ++++++ E+ I + E+L E + +
Sbjct: 188 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK----IDEKSETEKLLEYIEEISC 243
Query: 90 SDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDV---IQKYKKEQ 146
+ D EK + ++A + ++L E ++ L K+ + + I ++ +D+ Q +KE+
Sbjct: 244 ASDQ-VEKYKLDIA-QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 301
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+ + + +L E+ LK+K E+ KE +I++L E S
Sbjct: 302 EDHVNRNRE----HNENLNAEMQNLKQKFILEQQE-REKLQQKELQIDSLLQQEKELSSS 356
Query: 207 LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE 266
L +++ S E + KE +ELK+ + +L ++ Q++ L+E + EE
Sbjct: 357 LHQKLCS---FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE 413
Query: 267 RFELTEALSQAREQLLELS 285
+L E + +E LE S
Sbjct: 414 -LKLLEEKLKGKEAELEKS 431
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 51/257 (19%)
Query: 1 MLLKEKEDSLM------TCQ-QIYKAL---------------QEELTVKEKQEEDIKRRI 38
+LL+EK DS++ T Q + YKAL QE+ K ED++ +I
Sbjct: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
Query: 39 NLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKI 98
E+ + +L + + + E + + +S + I LQ L+Q+ ++++++++
Sbjct: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ---EEDFRKQL 556
Query: 99 E------AELAKERAQHLVEFEEQALLFKE---ETK---LQLDIEKEKHQDVIQKYKKEQ 146
E AE A+ E + LL++E +TK LQLD + + Q ++ ++ Q
Sbjct: 557 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 616
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+L KI D LK+K+ H ++ NS+ LK+ V++ +
Sbjct: 617 EQLN-KIRDSYAKLLGH-----QNLKQKI--KHVVKLKDENSQ------LKSEVSKLRCQ 662
Query: 207 LKKEIDSNDSVSENLRK 223
L K+ S + E L K
Sbjct: 663 LAKKKQSETKLQEELNK 679
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 68.2 bits (165), Expect = 1e-11
Identities = 78/302 (25%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
LKEK D +++ +Q +L+E + + KQ ED+ + L E E E +N+ RE L
Sbjct: 246 LKEKNDEILSLKQ---SLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNENL 299
Query: 63 KNERELMLISHQKSI--EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQAL-- 118
E + + QK I +Q +E L+QK L D+ ++ E EL+ Q L F+E+ +
Sbjct: 300 NAEMQNL---KQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQEEMVKE 355
Query: 119 --LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEK-- 174
LF+EE K LD D +Q+ +++ E L ++ + +L+ LK K
Sbjct: 356 KNLFEEELKQTLD-----ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 410
Query: 175 -LHKSHTRYTEES----NSKEKEIENLKNLVAEFES---RLKKEID----SNDSVSENLR 222
L KS +T+ + + +++L+++ A+FES EI+ N S+ E
Sbjct: 411 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 470
Query: 223 KEMEQKSDELKRVMLAQTQLIEQFNQ--SQEENTFLQETVRRECEERF--ELTEALSQAR 278
K + D +++ ++ E + + L+ET +E F ++T+ +Q +
Sbjct: 471 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 530
Query: 279 EQ 280
+Q
Sbjct: 531 QQ 532
Score = 55.1 bits (131), Expect = 1e-07
Identities = 70/308 (22%), Positives = 128/308 (41%), Gaps = 26/308 (8%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKN 64
+K+ +L + K+ + ++ V ++ RRI E ELE + LN E +L +
Sbjct: 57 DKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL-S 115
Query: 65 ERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEET 124
L + + E L+ K + N K ++ E L K ET
Sbjct: 116 ANNATLEKQLIELTRTNELLKSKFSENGNQKN-----------LRILSLELMKLRNKRET 164
Query: 125 KLQLDIEKEKHQDV-IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
K++ + K++ ++ +Q ++ EE Q KI+ L G + +E K + K Y
Sbjct: 165 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL-EGKLVSIEKEKIDEKSETEKL-LEYI 222
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDS----NDSVSENLRKEMEQKSDELKRVMLAQ 239
EE + ++E K +A+ E LK++ D S+ EN+ +Q D + L +
Sbjct: 223 EEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE 282
Query: 240 TQLIEQFNQSQEENTFLQETVRR-------ECEERFELTEALSQAREQLLELSKLRGSLP 292
+ + N+++E N L ++ E +ER +L + Q L + +L SL
Sbjct: 283 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH 342
Query: 293 FSPCSLSK 300
CS +
Sbjct: 343 QKLCSFQE 350
Score = 46.2 bits (108), Expect = 5e-05
Identities = 55/259 (21%), Positives = 122/259 (47%), Gaps = 18/259 (6%)
Query: 30 QEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLL 89
++E ++ ++ + + LE ++ + Q ++++++ E+ I + E+L E + +
Sbjct: 172 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK----IDEKSETEKLLEYIEEISC 227
Query: 90 SDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDV---IQKYKKEQ 146
+ D EK + ++A + ++L E ++ L K+ + + I ++ +D+ Q +KE+
Sbjct: 228 ASDQ-VEKYKLDIA-QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 285
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+ + + +L E+ LK+K E+ KE +I++L E S
Sbjct: 286 EDHVNRNRE----HNENLNAEMQNLKQKFILEQQE-REKLQQKELQIDSLLQQEKELSSS 340
Query: 207 LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE 266
L +++ S E + KE +ELK+ + +L ++ Q++ L+E + EE
Sbjct: 341 LHQKLCS---FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE 397
Query: 267 RFELTEALSQAREQLLELS 285
+L E + +E LE S
Sbjct: 398 -LKLLEEKLKGKEAELEKS 415
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 51/257 (19%)
Query: 1 MLLKEKEDSLM------TCQ-QIYKAL---------------QEELTVKEKQEEDIKRRI 38
+LL+EK DS++ T Q + YKAL QE+ K ED++ +I
Sbjct: 424 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 483
Query: 39 NLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKI 98
E+ + +L + + + E + + +S + I LQ L+Q+ ++++++++
Sbjct: 484 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ---EEDFRKQL 540
Query: 99 E------AELAKERAQHLVEFEEQALLFKE---ETK---LQLDIEKEKHQDVIQKYKKEQ 146
E AE A+ E + LL++E +TK LQLD + + Q ++ ++ Q
Sbjct: 541 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 600
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+L KI D LK+K+ H ++ NS+ LK+ V++ +
Sbjct: 601 EQLN-KIRDSYAKLLGH-----QNLKQKI--KHVVKLKDENSQ------LKSEVSKLRCQ 646
Query: 207 LKKEIDSNDSVSENLRK 223
L K+ S + E L K
Sbjct: 647 LAKKKQSETKLQEELNK 663
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 68.2 bits (165), Expect = 1e-11
Identities = 78/302 (25%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
LKEK D +++ +Q +L+E + + KQ ED+ + L E E E +N+ RE L
Sbjct: 261 LKEKNDEILSLKQ---SLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNENL 314
Query: 63 KNERELMLISHQKSI--EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQAL-- 118
E + + QK I +Q +E L+QK L D+ ++ E EL+ Q L F+E+ +
Sbjct: 315 NAEMQNL---KQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQEEMVKE 370
Query: 119 --LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEK-- 174
LF+EE K LD D +Q+ +++ E L ++ + +L+ LK K
Sbjct: 371 KNLFEEELKQTLD-----ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 425
Query: 175 -LHKSHTRYTEES----NSKEKEIENLKNLVAEFES---RLKKEID----SNDSVSENLR 222
L KS +T+ + + +++L+++ A+FES EI+ N S+ E
Sbjct: 426 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 485
Query: 223 KEMEQKSDELKRVMLAQTQLIEQFNQ--SQEENTFLQETVRRECEERF--ELTEALSQAR 278
K + D +++ ++ E + + L+ET +E F ++T+ +Q +
Sbjct: 486 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 545
Query: 279 EQ 280
+Q
Sbjct: 546 QQ 547
Score = 56.2 bits (134), Expect = 5e-08
Identities = 70/295 (23%), Positives = 123/295 (41%), Gaps = 26/295 (8%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
K L++E+ V ++ RRI E ELE + LN E +L + L +
Sbjct: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL-SANNATLEKQLIEL 143
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
+ E L+ K + N K ++ E L K ETK++ + K++ +
Sbjct: 144 TRTNELLKSKFSENGNQKN-----------LRILSLELMKLRNKRETKMRGMMAKQEGME 192
Query: 138 V-IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENL 196
+ +Q ++ EE Q KI+ L G + +E K + K Y EE + ++E
Sbjct: 193 MKLQVTQRSLEESQGKIAQL-EGKLVSIEKEKIDEKSETEKL-LEYIEEISCASDQVEKY 250
Query: 197 KNLVAEFESRLKKEIDS----NDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEE 252
K +A+ E LK++ D S+ EN+ +Q D + L + + + N+++E
Sbjct: 251 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 310
Query: 253 NTFLQETVRR-------ECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK 300
N L ++ E +ER +L + Q L + +L SL CS +
Sbjct: 311 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 365
Score = 46.2 bits (108), Expect = 5e-05
Identities = 55/259 (21%), Positives = 122/259 (47%), Gaps = 18/259 (6%)
Query: 30 QEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLL 89
++E ++ ++ + + LE ++ + Q ++++++ E+ I + E+L E + +
Sbjct: 187 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK----IDEKSETEKLLEYIEEISC 242
Query: 90 SDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDV---IQKYKKEQ 146
+ D EK + ++A + ++L E ++ L K+ + + I ++ +D+ Q +KE+
Sbjct: 243 ASDQ-VEKYKLDIA-QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+ + + +L E+ LK+K E+ KE +I++L E S
Sbjct: 301 EDHVNRNRE----HNENLNAEMQNLKQKFILEQQE-REKLQQKELQIDSLLQQEKELSSS 355
Query: 207 LKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE 266
L +++ S E + KE +ELK+ + +L ++ Q++ L+E + EE
Sbjct: 356 LHQKLCS---FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE 412
Query: 267 RFELTEALSQAREQLLELS 285
+L E + +E LE S
Sbjct: 413 -LKLLEEKLKGKEAELEKS 430
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 51/257 (19%)
Query: 1 MLLKEKEDSLM------TCQ-QIYKAL---------------QEELTVKEKQEEDIKRRI 38
+LL+EK DS++ T Q + YKAL QE+ K ED++ +I
Sbjct: 439 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 498
Query: 39 NLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKI 98
E+ + +L + + + E + + +S + I LQ L+Q+ ++++++++
Sbjct: 499 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ---EEDFRKQL 555
Query: 99 E------AELAKERAQHLVEFEEQALLFKE---ETK---LQLDIEKEKHQDVIQKYKKEQ 146
E AE A+ E + LL++E +TK LQLD + + Q ++ ++ Q
Sbjct: 556 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 615
Query: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESR 206
E+L KI D LK+K+ H ++ NS+ LK+ V++ +
Sbjct: 616 EQLN-KIRDSYAKLLGH-----QNLKQKI--KHVVKLKDENSQ------LKSEVSKLRCQ 661
Query: 207 LKKEIDSNDSVSENLRK 223
L K+ S + E L K
Sbjct: 662 LAKKKQSETKLQEELNK 678
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/259 (25%), Positives = 130/259 (50%), Gaps = 25/259 (9%)
Query: 41 AENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEA 100
AE + +I K L+ + E+ L+N+++ +H K +E L+ L + + +N E I +
Sbjct: 611 AELKTQIEKMRLDY-QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRS 669
Query: 101 ELAKERAQHLVEFEEQALLFKE-ETKLQ----LDIEKEKHQDVIQKYKKEQEELQMKISD 155
+L K QHLVE E+ +E E K++ L + + VI + + + + K+ D
Sbjct: 670 KLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 729
Query: 156 L--ITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDS 213
L + A+ + + E+ L+++L E + + K +E KN + S + +E+
Sbjct: 730 LDALRKASSEGKSEMKKLRQQL--------EAAEKQIKHLEIEKNAESSKASSITRELQG 781
Query: 214 NDSVSENLRKEMEQKSDELKRVMLAQTQLI-EQFNQSQEE----NTFLQETVRR--ECEE 266
+ NL++ + + S ++K + + Q++ E+F ++ EE +QETV + + EE
Sbjct: 782 RELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 840
Query: 267 RFE-LTEALSQAREQLLEL 284
+F L+ L + RE L ++
Sbjct: 841 QFNMLSSDLEKLRENLADM 859
Score = 56.6 bits (135), Expect = 4e-08
Identities = 85/348 (24%), Positives = 150/348 (43%), Gaps = 53/348 (15%)
Query: 21 QEELTVKEKQEEDIKRRINLA-ENELEITKT-----LLNQTREEV---LTLKNERELMLI 71
++ + KEK E DI + ++ +N ++TK L + EE+ LT NE L
Sbjct: 871 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL- 929
Query: 72 SHQKSIEQL----QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
QKSIE + +++ ++ + K+++E +L+ + + + Q K +
Sbjct: 930 --QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS-DLEKKMETSHNQCQELKARYERA 986
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD---LRQEVTTLKEKLHKSHTRYTE 184
K KH++++Q +K + + D + GA + L QE+ L+++ K+ T
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTE----DKLKGAREENSGLLQELEELRKQADKAKAAQTA 1042
Query: 185 ESN-------SKEK-----EIENLKNLVAEFESRLKKEIDSNDSVSENLRK--------- 223
E +KEK +E+ K A+ ++ L ++N E L K
Sbjct: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1102
Query: 224 -EMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE---RFELTEALSQARE 279
+ME+ E++ + A Q +Q + QEEN L E + R +E +L E S
Sbjct: 1103 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1162
Query: 280 QLLELSKLRGSLPFSPCSLSKGSL---TSPAAAVSNHGERSLARLNSE 324
QLLE+ K R S K SL S +A+ + L +L +E
Sbjct: 1163 QLLEMKK-RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE 1209
Score = 47.0 bits (110), Expect = 3e-05
Identities = 69/328 (21%), Positives = 144/328 (43%), Gaps = 62/328 (18%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQE----EDIKRRINLAENELEITKTLLNQTRE 57
++KEKE+SL +A++ +L E Q ED ++ AE +++ + L + E
Sbjct: 656 VIKEKENSL-------EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 708
Query: 58 EVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL--AKERAQHLVEFEE 115
+ + N + + +K ++ + LR+ + +K+ +L A+++ +HL E E+
Sbjct: 709 QTKVIDNFTSQLKATEEKLLDL--DALRKASSEGKSEMKKLRQQLEAAEKQIKHL-EIEK 765
Query: 116 QALLFKEET--------KLQLDIEKEKHQDVIQKYKKEQEELQM------KISDLITGAT 161
A K + +L+L +E +V Q + ++ELQ+ + S+
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825
Query: 162 RDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEF-------------ESRLK 208
R +++ V KLH+ ++ S+ EK ENL ++ A+F + +L+
Sbjct: 826 RSMQETVN----KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE 881
Query: 209 KEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFL------------ 256
+I +S + ++ + +DEL+ +L + ++ E +FL
Sbjct: 882 NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941
Query: 257 ---QETVRRECEERFELTEALSQAREQL 281
QE ++ EE+ EL LS +++
Sbjct: 942 QSQQEAAKKHEEEKKELERKLSDLEKKM 969
Score = 45.8 bits (107), Expect = 7e-05
Identities = 63/284 (22%), Positives = 119/284 (41%), Gaps = 28/284 (9%)
Query: 19 ALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIE 78
ALQE L K++ E + LAE +LE + + + V ++ E L H + +
Sbjct: 352 ALQEALKEKQQHIEQL-----LAERDLE--RAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 79 QLQETLRQ-KLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
+L+ + Q + + + +EK+E E + VE + + + TK L++ +
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKS 464
Query: 138 VIQKYKK-------EQEELQMKISDLITGATRD----LRQEVTTLKEKLHKSHTRYTEES 186
I + +K E EL+ ++ D L QE+++L+EKL + T +
Sbjct: 465 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH---- 520
Query: 187 NSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQF 246
++EI +LK E +KEI + + +E L KE E +L+ + +I +
Sbjct: 521 ---QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 577
Query: 247 NQSQEENTFLQETVRRECEERFE--LTEALSQAREQLLELSKLR 288
E + E + F L ++ E ++ K+R
Sbjct: 578 KSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 621
Score = 41.6 bits (96), Expect = 0.001
Identities = 56/254 (22%), Positives = 108/254 (42%), Gaps = 38/254 (14%)
Query: 2 LLKEKEDSLMTCQ---QIYKALQEEL-TVKEKQEEDIKRRINLAENELEITKTLLNQTRE 57
+ KEK ++L + + Q LQ EL T+KE ++++ +N ++ L + + + R+
Sbjct: 1052 MTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE-LNKSKELLTVENQKMEEFRK 1110
Query: 58 EVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQA 117
E+ TLK Q++ + L ++N K E +++ + EE+
Sbjct: 1111 EIETLKQ-------------AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER 1157
Query: 118 LLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGA--------TRDLRQEVT 169
+ QL K++ I+ +E+ LQ IS IT A LR EVT
Sbjct: 1158 SVLNN----QLLEMKKRESKFIKDADEEKASLQKSIS--ITSALLTEKDAELEKLRNEVT 1211
Query: 170 TLK------EKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRK 223
L+ + LH + E +++NL+ + E + +L + D+ ++ +
Sbjct: 1212 VLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER 1271
Query: 224 EMEQKSDELKRVML 237
E + D L V++
Sbjct: 1272 AQESQIDFLNSVIV 1285
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/259 (25%), Positives = 130/259 (50%), Gaps = 25/259 (9%)
Query: 41 AENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEA 100
AE + +I K L+ + E+ L+N+++ +H K +E L+ L + + +N E I +
Sbjct: 646 AELKTQIEKMRLDY-QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRS 704
Query: 101 ELAKERAQHLVEFEEQALLFKE-ETKLQ----LDIEKEKHQDVIQKYKKEQEELQMKISD 155
+L K QHLVE E+ +E E K++ L + + VI + + + + K+ D
Sbjct: 705 KLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 764
Query: 156 L--ITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDS 213
L + A+ + + E+ L+++L E + + K +E KN + S + +E+
Sbjct: 765 LDALRKASSEGKSEMKKLRQQL--------EAAEKQIKHLEIEKNAESSKASSITRELQG 816
Query: 214 NDSVSENLRKEMEQKSDELKRVMLAQTQLI-EQFNQSQEE----NTFLQETVRR--ECEE 266
+ NL++ + + S ++K + + Q++ E+F ++ EE +QETV + + EE
Sbjct: 817 RELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 875
Query: 267 RFE-LTEALSQAREQLLEL 284
+F L+ L + RE L ++
Sbjct: 876 QFNMLSSDLEKLRENLADM 894
Score = 56.6 bits (135), Expect = 4e-08
Identities = 85/348 (24%), Positives = 150/348 (43%), Gaps = 53/348 (15%)
Query: 21 QEELTVKEKQEEDIKRRINLA-ENELEITKT-----LLNQTREEV---LTLKNERELMLI 71
++ + KEK E DI + ++ +N ++TK L + EE+ LT NE L
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL- 964
Query: 72 SHQKSIEQL----QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQ 127
QKSIE + +++ ++ + K+++E +L+ + + + Q K +
Sbjct: 965 --QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS-DLEKKMETSHNQCQELKARYERA 1021
Query: 128 LDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD---LRQEVTTLKEKLHKSHTRYTE 184
K KH++++Q +K + + D + GA + L QE+ L+++ K+ T
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTE----DKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077
Query: 185 ESN-------SKEK-----EIENLKNLVAEFESRLKKEIDSNDSVSENLRK--------- 223
E +KEK +E+ K A+ ++ L ++N E L K
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1137
Query: 224 -EMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEE---RFELTEALSQARE 279
+ME+ E++ + A Q +Q + QEEN L E + R +E +L E S
Sbjct: 1138 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1197
Query: 280 QLLELSKLRGSLPFSPCSLSKGSL---TSPAAAVSNHGERSLARLNSE 324
QLLE+ K R S K SL S +A+ + L +L +E
Sbjct: 1198 QLLEMKK-RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE 1244
Score = 47.0 bits (110), Expect = 3e-05
Identities = 69/328 (21%), Positives = 144/328 (43%), Gaps = 62/328 (18%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQE----EDIKRRINLAENELEITKTLLNQTRE 57
++KEKE+SL +A++ +L E Q ED ++ AE +++ + L + E
Sbjct: 691 VIKEKENSL-------EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 743
Query: 58 EVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAEL--AKERAQHLVEFEE 115
+ + N + + +K ++ + LR+ + +K+ +L A+++ +HL E E+
Sbjct: 744 QTKVIDNFTSQLKATEEKLLDL--DALRKASSEGKSEMKKLRQQLEAAEKQIKHL-EIEK 800
Query: 116 QALLFKEET--------KLQLDIEKEKHQDVIQKYKKEQEELQM------KISDLITGAT 161
A K + +L+L +E +V Q + ++ELQ+ + S+
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860
Query: 162 RDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEF-------------ESRLK 208
R +++ V KLH+ ++ S+ EK ENL ++ A+F + +L+
Sbjct: 861 RSMQETVN----KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE 916
Query: 209 KEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFL------------ 256
+I +S + ++ + +DEL+ +L + ++ E +FL
Sbjct: 917 NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 976
Query: 257 ---QETVRRECEERFELTEALSQAREQL 281
QE ++ EE+ EL LS +++
Sbjct: 977 QSQQEAAKKHEEEKKELERKLSDLEKKM 1004
Score = 46.6 bits (109), Expect = 4e-05
Identities = 56/267 (20%), Positives = 119/267 (44%), Gaps = 37/267 (13%)
Query: 42 ENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAE 101
E +++ +T++ E + L N+ E ++ +E LQ + ++ ++ K +E +
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLE----EEKRKVEDLQFRVEEESIT----KGDLETQ 458
Query: 102 LAKERAQHLVEFEEQALLFKEET--KLQLDIEKEKHQDVIQKYK--KEQEELQMKISDLI 157
E A+ ++ EQ+LLF++ KLQ ++E + V +K + + +++L +++ ++
Sbjct: 459 TKLEHAR--IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVA 516
Query: 158 TGATR--------------DLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEF 203
R L QE+++L+EKL + T + ++EI +LK
Sbjct: 517 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH-------QREITSLKEHFGAR 569
Query: 204 ESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRE 263
E +KEI + + +E L KE E +L+ + +I + E + E
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Query: 264 CEERFE--LTEALSQAREQLLELSKLR 288
+ F L ++ E ++ K+R
Sbjct: 630 LKVSFSKGLGTETAEFAELKTQIEKMR 656
Score = 41.6 bits (96), Expect = 0.001
Identities = 56/254 (22%), Positives = 108/254 (42%), Gaps = 38/254 (14%)
Query: 2 LLKEKEDSLMTCQ---QIYKALQEEL-TVKEKQEEDIKRRINLAENELEITKTLLNQTRE 57
+ KEK ++L + + Q LQ EL T+KE ++++ +N ++ L + + + R+
Sbjct: 1087 MTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE-LNKSKELLTVENQKMEEFRK 1145
Query: 58 EVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQA 117
E+ TLK Q++ + L ++N K E +++ + EE+
Sbjct: 1146 EIETLKQ-------------AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER 1192
Query: 118 LLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGA--------TRDLRQEVT 169
+ QL K++ I+ +E+ LQ IS IT A LR EVT
Sbjct: 1193 SVLNN----QLLEMKKRESKFIKDADEEKASLQKSIS--ITSALLTEKDAELEKLRNEVT 1246
Query: 170 TLK------EKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRK 223
L+ + LH + E +++NL+ + E + +L + D+ ++ +
Sbjct: 1247 VLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER 1306
Query: 224 EMEQKSDELKRVML 237
E + D L V++
Sbjct: 1307 AQESQIDFLNSVIV 1320
Score = 33.5 bits (75), Expect = 0.33
Identities = 32/136 (23%), Positives = 57/136 (41%), Gaps = 8/136 (5%)
Query: 169 TTLKEKLHKSHTRYTE---ESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEM 225
T L+E L + + E + + E+ + V E E L D +D E+
Sbjct: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV----LEL 406
Query: 226 EQKSDELKRVM-LAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLEL 284
E K D+L+ ++ A + +E NQ +EE +++ R EE + +Q + + +
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI 466
Query: 285 SKLRGSLPFSPCSLSK 300
+L SL F K
Sbjct: 467 KELEQSLLFEKTKADK 482
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 66.6 bits (161), Expect = 4e-11
Identities = 79/339 (23%), Positives = 147/339 (43%), Gaps = 50/339 (14%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDI---KRRINLA-----ENELEITKTLLNQTR 56
E E + + Q+Y++ E+ +++Q + I K + L + E+EI L+
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935
Query: 57 EEVLTLKNERELMLISHQKSIE-------QLQETLRQKLLSDDNWKEKIEAELAKERAQH 109
+ + L E E + +K +E ++QETL++KLL EA+L KE
Sbjct: 936 DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ-------EAKLKKELENT 988
Query: 110 LVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVT 169
+E ++ F + D + + + Q+E +I L R+L ++
Sbjct: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE---QIESLTEVHRRELNDVIS 1045
Query: 170 TLKEKLHKSHTRYTE----ESNSKEKEIENLKNLVAEFESR----------LKKEIDSND 215
++KL++ E + KE+E+ LK + F LK+E D
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD 1105
Query: 216 SVSENLRKEMEQKSDELKRVMLAQTQL---IEQ----FNQSQEENTFLQETV----RREC 264
+ L+++++QKS + + +T+L +E+ N+S +ENTFLQE +
Sbjct: 1106 TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
Query: 265 EERFELTEALSQAREQLLELSKLRGSLPFSPCSLSKGSL 303
E++ +++E S+ + E L+ S S SL SL
Sbjct: 1166 EDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Score = 65.1 bits (157), Expect = 1e-10
Identities = 73/293 (24%), Positives = 136/293 (46%), Gaps = 39/293 (13%)
Query: 4 KEKEDSLMTCQQIYKALQEELT--VKEKQEEDIKRRINLAENEL-----EITKTLLNQTR 56
K E+ ++ QQ +++E+ +K+ EE I + L E EL E+TK L + R
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 57 E-----EVLTLKNERELMLISHQK------SIEQLQETLRQKLLSDDNWKEKIEAELAKE 105
E +V K++ E + IS +K ++E+L+ + L +N ++ E
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 106 RAQHLVEFEEQALLFKEETKLQ-------LDIEKEKHQD----VIQKYKKEQEELQMKIS 154
R + ++E E +E K Q L+ EK KH +++K+K E E L+ +
Sbjct: 566 RTR-ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD 624
Query: 155 DLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSN 214
L T + L+Q+ T EKL + +E+ K+KEI A E +K ++
Sbjct: 625 ALWTEKLQVLKQQYQTEMEKL-REKCEQEKETLLKDKEI----IFQAHIEEMNEKTLEKL 679
Query: 215 DSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEER 267
D + E+E S EL V+ A+ +L E+ + +++ +++ + + +E+
Sbjct: 680 DV----KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Score = 62.4 bits (150), Expect = 7e-10
Identities = 59/260 (22%), Positives = 121/260 (46%), Gaps = 27/260 (10%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
+KE + L+ +++++ EELT K ++ + +++ + + T+ L T E
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM----DGRNKPTELLEENTEE----- 1906
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
K++ L+ ++E L KL + K+K+ E+ V ++ + ++
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI--------VRLQKDLRMLRK 1958
Query: 123 ETKLQLDI-EKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVT--------TLKE 173
E + +L+I +KE Q+ +K K+EQE+L++K + + R+ ++ T+KE
Sbjct: 1959 EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 174 KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELK 233
++K+ E S ++E L +AE + LK+ + + + +EM K +L
Sbjct: 2019 TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL- 2077
Query: 234 RVMLAQTQLIEQFNQSQEEN 253
+ L + Q Q QEEN
Sbjct: 2078 QTQLEELQKKYQQKLEQEEN 2097
Score = 60.1 bits (144), Expect = 3e-09
Identities = 76/365 (20%), Positives = 151/365 (41%), Gaps = 86/365 (23%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKT---LLNQTREE 58
+LK++ D + Q++ + E+ ++Q + I + E+E+ I +T L +Q +
Sbjct: 709 VLKDQTDKMK--QELEAKMDEQKNHHQQQVDSI-----IKEHEVSIQRTEKALKDQINQL 761
Query: 59 VLTLKNERELMLISHQKSIEQLQETLR----------------QKLLSDDNWKEKIEAEL 102
L LK ER+ L HQ +E L+ ++ Q S + + K E
Sbjct: 762 ELLLK-ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
Query: 103 AKERAQHLVEFEEQALLF----------KEETKLQLDIEKEKHQDVIQKYKKEQEELQMK 152
+ Q L++ E + +L K++ +LD K + QD++Q+ +K+ E++ K
Sbjct: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
Query: 153 ISDLI--------------------------------TGATRD---LRQEVTTLKEKLHK 177
+ L G ++ L Q+++ ++ +H
Sbjct: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Query: 178 SHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDS----VSENLRKEMEQKSDELK 233
+ Y + ++EK++E +K E + LKK++ ++ EN E+ QK +
Sbjct: 941 LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 234 RVMLAQTQ--------LIEQFNQSQEEN-TFLQETVRRECEERFELTE-ALSQAREQLLE 283
ML Q + + +Q+E L E RRE + + E L+Q E+L E
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 284 LSKLR 288
+ +++
Sbjct: 1061 IHEIQ 1065
Score = 55.5 bits (132), Expect = 8e-08
Identities = 65/298 (21%), Positives = 142/298 (47%), Gaps = 14/298 (4%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT- 61
+K +E+ L C++ ++ +E+ T+ ++E ++ +++ ELE K L + +++T
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ 347
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
L++ + L+ Q + ET RQ + KE+ A+L + R + + E+ K
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQ-MHETLEMKEEEIAQL-RSRIKQMTTQGEELREQK 405
Query: 122 EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTR 181
E+++ E EK QK ++ + +L+ ++ + I + +E +L+++L +
Sbjct: 406 EKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE 465
Query: 182 YTE-ESNSKEKEIENLKNL----VAEFESRLKKEIDSND-SVSENLRKEMEQKSDELKRV 235
+ S E++I L+ L +A E L K++ + + E ++ +E+ E ++
Sbjct: 466 VVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKI 525
Query: 236 MLAQTQLIEQFNQSQEENTFLQETVRRECEERF-ELTEALSQAREQLLEL-SKLRGSL 291
+ Q Q + + EE ++ + E E + +L + R ++LEL S L SL
Sbjct: 526 SQEKEQ---QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Score = 55.5 bits (132), Expect = 8e-08
Identities = 72/283 (25%), Positives = 127/283 (44%), Gaps = 41/283 (14%)
Query: 4 KEKEDSLMTCQQ-IYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
K+K S T Q K LQ +L +K K+ + +INL + EL+ Q + L
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD-------QQNKRFDCL 1498
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
K E E + +E+ + L +L S ++E + Q +E E + K
Sbjct: 1499 KGEME----DDKSKMEKKESNLETELKSQTARIMELEDHI----TQKTIEIESLNEVLKN 1550
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ Q DIE H++++QK + QE + + ++ +++ TL+ +++
Sbjct: 1551 YNQ-QKDIE---HKELVQKLQHFQE-----LGEEKDNRVKEAEEKILTLENQVYSMKA-- 1599
Query: 183 TEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVS----ENLRKEMEQKSDELKRVMLA 238
E +K+KE+E++ V E LK D +S S L+++ EQK +K+ +L+
Sbjct: 1600 --ELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 239 Q-TQLIEQFNQSQEE-----NTFLQETVRRE--CEERFELTEA 273
Q + EQ+ + E NT LQE R EE+ + E+
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Score = 49.7 bits (117), Expect = 5e-06
Identities = 70/319 (21%), Positives = 142/319 (44%), Gaps = 41/319 (12%)
Query: 3 LKEKEDSLMTCQQ---IYKALQEELT--VKEKQEEDIKR--RINLAENELEITKTLLNQT 55
L+EKE + +Q ++ +EE+ + +EE +K+ +N + +L+ +N
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125
Query: 56 REEVLTLKNERELMLISHQKSIEQ---LQETLRQ-KLLSDDNWKEKIEAELAK-----ER 106
++ LK E + + KS+++ LQE L + K+L++++ K K+ +K E
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED-KRKVSELTSKLKTTDEE 1184
Query: 107 AQHLVE--------FEEQALLFK---EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISD 155
Q L E+++L FK EE +QLDI +K + +++ E + ++
Sbjct: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244
Query: 156 LITGATRDLRQEVTTLKE----------KLHKSHTRYTEESNSKEKEIENLKNLVAEFES 205
I + T +KE +L + TEE N+ + + + E E+
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 206 RLKK---EIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRR 262
++K +I+S + E L+KE + TQL ++ +++ T ++E ++
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 263 ECEERFELTEALSQAREQL 281
+ E L++ L+ QL
Sbjct: 1365 KKVEISSLSKQLTDLNVQL 1383
Score = 49.3 bits (116), Expect = 6e-06
Identities = 69/303 (22%), Positives = 132/303 (43%), Gaps = 50/303 (16%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
LK ++D+L T E+L V ++Q + E+E + Q +E TL
Sbjct: 619 LKHQQDALWT---------EKLQVLKQQYQ----------TEMEKLREKCEQEKE---TL 656
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKE-RAQHLVEFE-----EQ 116
++E++ +H IE++ E +KL E + +EL++ +A+H +E E +Q
Sbjct: 657 LKDKEIIFQAH---IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ 713
Query: 117 ALLFKEETKLQLDIEKEKHQDVIQKYKKEQE----ELQMKISDLITGATRDLRQEVTTLK 172
K+E + ++D +K HQ + KE E + + D I L++ LK
Sbjct: 714 TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773
Query: 173 EKLHKSHTRYTE-ESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD- 230
E H++H E + E E++ + F+S + + E L + ++ D
Sbjct: 774 E--HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Query: 231 ELKRVMLAQTQLIEQFNQSQEENT----------FLQETVRRECEERFELTEALSQAREQ 280
E +R++L + Q+ E Q ++ T L + + ++ E + ++L+Q E
Sbjct: 832 ETERILLTK-QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 281 LLE 283
LE
Sbjct: 891 KLE 893
Score = 47.0 bits (110), Expect = 3e-05
Identities = 55/292 (18%), Positives = 133/292 (45%), Gaps = 25/292 (8%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELE-ITKTLLNQTREEVLT 61
+KE E+ ++T + +++ EL K+K+ E + + E EL+ + L +++ ++
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFK 121
LK + E + + +K QL + +K ++ +K+ E+ L+ E L E E + + +
Sbjct: 1640 LKRKAEQKIAAIKK---QLLSQMEEK---EEQYKKGTESHLS-ELNTKLQEREREVHILE 1692
Query: 122 EETKLQLDIEKEKHQDVI--QKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSH 179
E+ K +E + + +I + K + + +D + ++++ L+ L +
Sbjct: 1693 EKLK---SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 180 TRYTEESNSKEKEIENLKNLVAEFESRLKK------EIDSNDSVSENLRKEMEQKSDELK 233
KE+ + + + +++ RL K + + S+ +L++E+E+K+ +
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 234 RVMLAQTQLIEQFNQSQE----ENTFLQETVRRECEERFELTEALSQAREQL 281
++ + N Q EN F + V++ +E+ + L Q ++L
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVF--DDVQKTLQEKELTCQILEQKIKEL 1859
Score = 45.8 bits (107), Expect = 7e-05
Identities = 58/257 (22%), Positives = 111/257 (43%), Gaps = 22/257 (8%)
Query: 35 KRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNW 94
+ R + L I +++ ++ L E+ + IS Q++ QL+E Q +
Sbjct: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSM 1309
Query: 95 KEKIEAELA-KERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKI 153
K IE+ + KE Q ++QA KE QL E ++ + + K+E +E +++I
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI 1369
Query: 154 SDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDS 213
S L +++T L +L S + + KE I +L+ E + L ++
Sbjct: 1370 SSL--------SKQLTDLNVQLQNSISL-----SEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 214 NDSVSENLRKE----MEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFE 269
+ L KE +EQ D + + + +F Q Q LQ + + +E +E
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 270 LTEALSQAREQLLELSK 286
E ++ +E+L + +K
Sbjct: 1477 KDEQINLLKEELDQQNK 1493
Score = 43.5 bits (101), Expect = 3e-04
Identities = 66/339 (19%), Positives = 135/339 (39%), Gaps = 75/339 (22%)
Query: 4 KEKEDSLMTCQQIYK----ALQEELTVKEK--------QEEDIKRRINL----------- 40
+E+ DS Q+ Y+ LQ LT KEK +EE + +
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 41 --AENELEITKTLLNQTREEVLTLKNERELMLISH----------------QKSIEQLQE 82
AE + ++++ +EE+ + L++ H + + +Q+
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
Query: 83 TLRQKLLSDDNWKEKI---EAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVI 139
TL++K L+ ++KI ++ L +++ H VE EE +++ LQ + K +++
Sbjct: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
Query: 140 QKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNL 199
++ +E+ + + L++ + H + E+E + L
Sbjct: 1901 EENTEEKSKSHLVQPKLLSN---------------MEAQHNDLEFKLAGAEREKQKLGKE 1945
Query: 200 VAEFESRLKKEIDSNDSVSENLRKEMEQKSD----------ELKRVMLAQTQLIEQFN-- 247
+ + L+ + E L+KE +Q+ + ELK + QL+ +FN
Sbjct: 1946 IVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLK-QLMREFNTQ 2004
Query: 248 ---QSQEENTFLQETVRRECEERFELTEALSQAREQLLE 283
+ QE ++ET+ + E EL E+ + QLL+
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLK 2043
Score = 43.5 bits (101), Expect = 3e-04
Identities = 56/218 (25%), Positives = 100/218 (45%), Gaps = 39/218 (17%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
ML KE + L ++ Y +EE +E+++ ++K L + E L + +E +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 61 TLKN--------ERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVE 112
T+K E EL L SHQ+ QL + + +K DD+ K +R + +++
Sbjct: 2015 TIKETINKAQEVEAEL-LESHQEETNQLLKKIAEK---DDDLKR------TAKRYEEILD 2064
Query: 113 FEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLK 172
E+ + K LQ +E ++ +KY+++ E+ + +D +T + + T L
Sbjct: 2065 AREEEMTAKVRD-LQTQLE-----ELQKKYQQKLEQEENPGNDNVT-----IMELQTQLA 2113
Query: 173 EKLHKSHTRYTEESNSKEKEI-ENLKNLVAEFESRLKK 209
+K T +S KE+E E + NL E RLKK
Sbjct: 2114 QK-----TTLISDSKLKEQEFREQIHNL----EDRLKK 2142
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 65.9 bits (159), Expect = 6e-11
Identities = 77/297 (25%), Positives = 130/297 (43%), Gaps = 42/297 (14%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQL 80
Q E ++EE +RR E E E L EE + ER L + +++
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKE-----LQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 81 QETLR-QKLLSDDNWKEKIEAELAKERAQHLVEFE---------EQALLFKEETKLQLDI 130
QE R Q+ D W+ ++E E ++R +H + + EQ LL +EE +LQ +
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEE--RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 131 EKEKHQDVIQKYKKEQEELQMKISDLITGATRDLR----------------QEVTTLKEK 174
+++ + ++ +E+E+LQ + L+ R +E L E+
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 175 LHKSHTRYTEESNSKEKEI--ENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQ---KS 229
K + E+ +E+E+ E + L E E R ++E + + L++E EQ +
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFL---QETVRR-ECEERFELTEALSQAREQLL 282
E +R+ + Q E+ QEE L +ET RR E E ++ E L Q EQLL
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094
Score = 63.5 bits (153), Expect = 3e-10
Identities = 81/316 (25%), Positives = 141/316 (44%), Gaps = 46/316 (14%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQ--EEDIKRRINLAENELEITKTLLNQTR-EEV 59
L+E+ED L Q+ ++ ++ K + EE+ KRR + L L Q R E+
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR----RHTLYAKPALQEQLRKEQQ 904
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALL 119
L + E EL +K Q QE ++ ++ +++ E L +ER + +E+
Sbjct: 905 LLQEEEEELQREEREKRRRQEQE---RQYREEEQLQQEEEQLLREEREKR--RRQERERQ 959
Query: 120 FKEETKLQL--------DIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLR------ 165
++++ KLQ + EK + Q+ +KY +E+EELQ + L+ R
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKY-REEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 166 ----------QEVTTLKEKLHKSHTRYTEESNSKEKEI--ENLKNLVAEFESRLKKEIDS 213
+E L+E+ K + E +E+E+ E + L E E+R ++E++
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 214 NDSVSENLRKEMEQ---KSDELKRVMLAQTQLIEQFNQSQEENTFLQE----TVRRECEE 266
E L++E EQ + E +R + Q E+ QEE L+E R+E E
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 267 RFELTEALSQAREQLL 282
++ E + Q EQLL
Sbjct: 1139 QYREEEEVQQEEEQLL 1154
Score = 60.8 bits (146), Expect = 2e-09
Identities = 64/275 (23%), Positives = 127/275 (46%), Gaps = 35/275 (12%)
Query: 14 QQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISH 73
+Q+ K ++EL + ++EE ++R+ + + + +EE + RE
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 74 QKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKE 133
++ + + QE R++ L + +E+ E +L +E+ + E EQ L +++ + + + +E
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEE---ERREQQLRREQQLRREQQLRRE 392
Query: 134 KHQDVIQKYKKEQE---ELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKE 190
+ Q+ ++EQ+ E Q++ + LR+E +E+ + H E+ + +E
Sbjct: 393 QQLRREQQLRREQQLRREQQLR-------REQQLRREQQLRREQEEERH----EQKHEQE 441
Query: 191 KEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQ 250
+ + LK E LK+E E R E E++ +LKR +Q + +
Sbjct: 442 RREQRLKREQEERRDWLKRE-------EETERHEQERRKQQLKR---------DQEEERR 485
Query: 251 EENTFLQETVRRECEERFE--LTEALSQAREQLLE 283
E L+E RRE +ER E L + REQ L+
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Score = 60.5 bits (145), Expect = 3e-09
Identities = 65/306 (21%), Positives = 136/306 (44%), Gaps = 54/306 (17%)
Query: 21 QEELTVKEKQEEDIKRRINLAENELEITKTLLNQT---------REEVLTLKNERELMLI 71
+ E ++ +QEE ++R+ E E + + L ++ RE++L + E+ L
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 72 SHQKSIEQLQETLRQKLLSDD----------NWKEKIEAELAKERAQHLVEFEEQALLFK 121
++ +++ QE R +LL + +E++E L +E + L + E + K
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 122 -----EETKLQL---DIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE 173
EE + QL + ++E+ Q +++ ++E+ E ++K +E L++
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK-----------REEEEERLEQ 670
Query: 174 KLHKSHTRYTEESNSKEKE----IENLKNLVAEFESRLKKEIDSNDS-------VSENLR 222
+L + H E E+E E +K+ + +++ +L+ E D+ S E R
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 223 KEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLL 282
+ EQ+ +R Q Q E+ ++ Q+E E RR+ +++ E + R++L
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQE-----EEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 283 ELSKLR 288
LR
Sbjct: 786 ARPPLR 791
Score = 60.1 bits (144), Expect = 3e-09
Identities = 68/284 (23%), Positives = 135/284 (47%), Gaps = 44/284 (15%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
L++KE+ L+ ++ K ++E K ++EE++++ + LL + RE+
Sbjct: 966 LQQKEEQLLG-EEPEKRRRQEREKKYREEEELQQE----------EEQLLREEREKRRRQ 1014
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
+ ER+ ++K E QE ++LL ++ K +++ + R + ++ EE+ LL +E
Sbjct: 1015 EWERQ-----YRKKDELQQE--EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
E + Q++ ++Y+K +EELQ + L LR+E + + + R
Sbjct: 1068 R-------ETRRRQELERQYRK-EEELQQEEEQL-------LREEPEKRRRQERERQCRE 1112
Query: 183 TEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQ---KSDELKRVMLAQ 239
EE +E+++ L E E R ++E++ E +++E EQ + E +R +
Sbjct: 1113 EEELQQEEEQL-----LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 240 TQLIEQFNQSQEENTFL---QETVRRECEERFELTEALSQAREQ 280
Q E+ QEE L QE R+E E ++ E L + + +
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Score = 59.7 bits (143), Expect = 4e-09
Identities = 62/302 (20%), Positives = 131/302 (43%), Gaps = 34/302 (11%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+++E QQ + EE ++ +++++ KRR ++ E ++ + + R T +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
RE + ++ + L+ R + ++ + + + E Q L E + KEE
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 124 TKLQL-DIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLK-----EKLHK 177
+L+ + E++ QD +K+++E+++L + D R R+E ++ K +
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERD------RKFREEEQQVRRQERERKFLE 1450
Query: 178 SHTRYTEESNSKEKEIENL----KNLVAEFESRLKKEIDSNDSVSENLR----KEMEQKS 229
+ +E + K +E E L + + R +K ++ + R +E E +S
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETV-----------RRECEERFELTEALSQAR 278
E +R L + Q Q ++ Q + FLQE R++ + +F E L Q R
Sbjct: 1511 QEPERKFLEEEQ---QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 279 EQ 280
E+
Sbjct: 1568 EE 1569
Score = 58.9 bits (141), Expect = 7e-09
Identities = 63/285 (22%), Positives = 124/285 (43%), Gaps = 36/285 (12%)
Query: 4 KEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLK 63
+E+ D L ++ + QE + K++++ +RR + E E + + +++ +
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 64 NERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
ER + Q+ E+LQ+ LR + +E+ E L +E + L + + L +E+
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 124 TKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
+ + + K + + Q+ K+EQEE L+++L
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEE---------------------RLEQRL-------- 602
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
K +E+E L+ E RLK+E + + + L K EQ+ +++ Q +
Sbjct: 603 -----KREEVERLEQ-EERREQRLKRE-EPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLR 288
EQ + +EE L++ ++RE EE E + +EQ E K R
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/287 (21%), Positives = 135/287 (47%), Gaps = 20/287 (6%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRR---INLAENELEITKTLLNQTRE 57
+L +E+E+ + K +EE ++E++E+ ++R+ E EL + E
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Query: 58 EVLTLKNERELMLISHQKSI--EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
E + ERE + ++ + ++ ++ LRQ D ++E+ E +L+++ EE
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQD--RDRKFREE-EQQLSRQERDRKFREEE 1436
Query: 116 QALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLR--QEVTTLKE 173
Q + +E + L+ E++ Q+ +K+++E++ LQ + + RD + +E L+
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 174 KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELK 233
+ R +E S+E E + L E E +L ++ + E + +++ + +
Sbjct: 1497 QERDRKFR-EQELRSQEPERKFL-----EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 234 RVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQ 280
+ + + EQ Q +EE Q+ R+E + +F L E + +EQ
Sbjct: 1551 QDRDRKFREEEQLRQEREE----QQLSRQERDRKFRLEEQKVRRQEQ 1593
Score = 54.7 bits (130), Expect = 1e-07
Identities = 59/290 (20%), Positives = 129/290 (44%), Gaps = 14/290 (4%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
L+ +++ QQ+ + +EE ++ + E RR E ++ + + +++
Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
+ R + ++ + + QE R + + +E+ +ER L EE +E
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 123 ETKLQL--DIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
K QL D E+E+ + ++ ++E+ E Q + + + R++ +E+ +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 181 RYTEESNSKEKEIENLKNLV-AEFESRLKKEIDSNDSVSENLRKEMEQKSDE-LKRVMLA 238
R E + ++ E + L+ E E RL++E + L++E E++ D+ LKR
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQE-----RREQRLKREQEERRDQLLKREEER 585
Query: 239 QTQLIEQFNQSQEENTFLQETVRR-----ECEERFELTEALSQAREQLLE 283
+ Q +++ + + E +E V R E+R + E + R+QLL+
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Score = 52.0 bits (123), Expect = 9e-07
Identities = 55/230 (23%), Positives = 108/230 (46%), Gaps = 16/230 (6%)
Query: 2 LLKEKEDSLMTCQQIYKALQEE---LTVKEKQEEDIKRRINLAENELEIT----KTLLNQ 54
LL+E E+ + Q+ + +EE L +E++ + ++ L ELE + L +
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Query: 55 TREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFE 114
T +E L + +L Q E+ ++ LR++ + + K + E +L +ER + + +
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ---ERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 115 EQALLFKEETKLQLDIEKE--KHQDVIQKYKKEQEELQMKISDLITGATRDLR---QEVT 169
E F+EE +L+ + E++ + Q KY+ E+E+LQ++ + RD + +E
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSE 219
+EK + +E K ++ E + L E R +KE + V E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQ-ERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 51.2 bits (121), Expect = 2e-06
Identities = 61/266 (22%), Positives = 122/266 (45%), Gaps = 39/266 (14%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
K +EE +E++E+ + R+ + LE K + + +E +++E++L Q+
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQK--VRRQEQERKFMEDEQQLR---RQEGQ 1610
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
+QL++ +K D+ ++ E + + + EE+ L ++E + QL ++++
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR--- 1667
Query: 138 VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLK 197
K+++E++ LQ G + LR++ K + + R E +E + L+
Sbjct: 1668 ---KFREEEQLLQ-------EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 198 NLVAEFESRLKKEIDSNDSVSENLRKEMEQ---KSDELKRVMLAQTQLIEQFNQSQEENT 254
E E + ++E E LR+E EQ + E R +L + EQ +EE
Sbjct: 1718 R--QELERKFREE--------EQLRQETEQEQLRRQERYRKILEE----EQLRPEREE-- 1761
Query: 255 FLQETVRRECEERFELTEALSQAREQ 280
Q+ R+E + +F E L Q RE+
Sbjct: 1762 --QQLRRQERDRKFREEEQLRQEREE 1785
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/259 (25%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 21 QEELTVKEKQ---EEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQ--- 74
+EEL +E+Q EE KRR E + K L Q E++L + ERE + +
Sbjct: 993 EEELQQEEEQLLREEREKRRRQEWERQYR-KKDELQQEEEQLL--REEREKRRLQERERQ 1049
Query: 75 -KSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKE 133
+ E+LQ+ Q L + + + E E + + L + EEQ L +EE EK
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ--LLREEP------EKR 1101
Query: 134 KHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEI 193
+ Q+ ++ +E+EELQ + L LR+E + + + R EE +E+++
Sbjct: 1102 RRQER-ERQCREEEELQQEEEQL-------LREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 194 ---ENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQ 250
E K E E + ++E + + LR+E E++ E +R Q + E+ + +
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER----QYREEEELQRQK 1209
Query: 251 EENTFLQETVRRECEERFE 269
+ + E R + + ++E
Sbjct: 1210 RKQRYRDEDQRSDLKWQWE 1228
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/276 (21%), Positives = 127/276 (46%), Gaps = 14/276 (5%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
L+ +E Q+ + +E+ + +++EE R LE L Q RE+ L
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ--QL 1661
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALL--- 119
+++R+ ++ +++ +E ++ D ++E+ + +ER + ++ E+Q
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 120 ---FKEETKLQLDIEKE--KHQDVIQKYKKEQEELQMKISDLITGATRDLR-QEVTTLKE 173
F+EE +L+ + E+E + Q+ +K +E++ + + RD + +E L++
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781
Query: 174 KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLR-KEMEQK-SDE 231
+ + R ++ES+ K +E E L+ E + R ++ E L+ +E EQ+ E
Sbjct: 1782 EREEQQLR-SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE 1840
Query: 232 LKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEER 267
R A+ Q Q +EE QE ++ +ER
Sbjct: 1841 RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Score = 48.9 bits (115), Expect = 8e-06
Identities = 74/325 (22%), Positives = 130/325 (40%), Gaps = 57/325 (17%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEED-------IKRRINLAENELEITKTLLNQ 54
LLK +E QQ+ + QE + K+EE+ +KR E E+ + Q
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 55 TREEVLT--------LKNE---RELMLISHQKSIE-----QLQETLRQKLLSDDNWKEKI 98
RE + + L++E R+ + S + E Q QE R++ S+ W+E
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE-- 750
Query: 99 EAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLIT 158
+ERA + EEQ F + + + E+ + + + +EQ E Q++ +
Sbjct: 751 -----EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE--- 802
Query: 159 GATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVS 218
R R++ +E+ + R E + + +E + L ++ +E +
Sbjct: 803 ---RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 219 ENLRKEMEQKSDELKRVML----------------AQTQLIEQFNQSQEENTFLQ----- 257
+ R+ EQ+ D+ R L Q QL ++ QEE LQ
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 258 ETVRRECEERFELTEALSQAREQLL 282
+ R+E E ++ E L Q EQLL
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLL 944
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/294 (22%), Positives = 124/294 (42%), Gaps = 26/294 (8%)
Query: 7 EDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNER 66
E+ Q+ ++ +EE + +++EE R LE + L Q R+ E+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF---REQ 1506
Query: 67 ELMLISHQKSI----EQLQETLRQ-KLLSDDNWKEKIEA---------ELAKERAQHLVE 112
EL ++ +QL RQ K L ++ + E +E Q E
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 113 FEEQALLFKE-ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD--LRQEVT 169
EEQ L +E + K +L+ +K + Q+ +K+ +++++L+ + RD R++
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 170 TLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKS 229
L+E+ + R + E+E + + E E +L+ + D E L +E E++
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQ---EREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 230 DELKRVMLAQTQLIEQFNQSQEENTFLQETV---RRECEERFELTEALSQAREQ 280
+ + +Q + + E FLQE R+E E +F E L Q EQ
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/286 (22%), Positives = 123/286 (43%), Gaps = 32/286 (11%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLL-----NQTREEVLTLKNERELMLIS 72
+ L+EE + +Q+ + R LAE E + K Q R+E L + +
Sbjct: 127 RQLEEEPGQRRRQKRQEQER-ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREE 185
Query: 73 HQKSIEQLQ-------------ETLRQKLLSDDNWKEKIEAELAK-ERAQHLVEFEEQAL 118
+ EQLQ E LR++ L + K + E + + ER + + EE+
Sbjct: 186 RRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE 245
Query: 119 LFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKS 178
K ET L+ + EK + ++ ++ + ++EE Q++ + RQE+ +++ +
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE---------RQELRRERQEEEQQ 296
Query: 179 HTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLA 238
R E + K+ E + E + ++ + + LR+E E++ ++ R
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 239 QTQLIEQFNQSQEENTFLQETVRRECEERFE--LTEALSQAREQLL 282
+ + +Q + QEE ++ +RRE + R E L REQ L
Sbjct: 357 EERREQQLRREQEEER-REQQLRREQQLRREQQLRREQQLRREQQL 401
Score = 46.6 bits (109), Expect = 4e-05
Identities = 71/286 (24%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 21 QEELTVKEKQ---EEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
+EEL +E+Q EE KRR E + + L +EE L+ ERE ++
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEEL---QQEEEQLLREERE------KRRR 1133
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLV-EFEEQALLFKEETKLQLDIEKEKHQ 136
++L+ R++ ++ + E K R Q L ++ E+ L +EE +L L E+EK +
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL-LREEQEKRR 1192
Query: 137 DVIQKYKKEQEELQ---MKISDLITGATRDLRQEVTTLKEKLHKSHT-----------RY 182
++ +E+EELQ K DL+ + KE + + R
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 183 TEESNSKEKEI-ENLKNLVAEFESRLK-------KEIDSNDSVSENLRKEMEQKSDELKR 234
E+S ++++ ++L++L+ E + R + ++ D + E L +E ++++ R
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 235 VMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQ 280
+ QL+ + +EE QET R+ EE E L Q RE+
Sbjct: 1313 KSQEEKQLL---REEREEKRRRQETDRKFREE-----EQLLQEREE 1350
Score = 44.7 bits (104), Expect = 1e-04
Identities = 66/292 (22%), Positives = 129/292 (44%), Gaps = 29/292 (9%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
L+++E+ L+ ++ K ++EL + ++EE++++ E E + + + R+E+
Sbjct: 1116 LQQEEEQLLR-EEREKRRRQELERQYREEEEVQQ-----EEEQLLREEPEKRRRQELERQ 1169
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
E E + ++ + + QE RQ+ +E+++ + K+R + E+Q +
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD----EDQ----RS 1221
Query: 123 ETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRY 182
+ K Q + EKE + Y K +E Q + L RD RQ L+ L + R
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFR--QLEDSQLRD-RQSQQDLQHLLGEQQERD 1278
Query: 183 TEES----NSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQK--SDELKRVM 236
E+ +++ + L E + K+ + + LR+E E+K E R
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 237 LAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLR 288
+ QL++ + +E+ QE R+ EE E Q R+ L E +LR
Sbjct: 1339 REEEQLLQ---EREEQPLRRQERDRKFREEELRHQE---QGRKFLEEEQRLR 1384
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 65.9 bits (159), Expect = 6e-11
Identities = 76/299 (25%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 5 EKEDSLMT-CQQIYKALQEELT-VKEKQEEDIKRRINLAENELEITKTL--LNQTREEVL 60
E E L+ Q+ K LQ ++ +KEK E + R + ++T+ L LN+ EEV
Sbjct: 1107 ENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV- 1165
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWK----EKIEAELAKERAQHLVEFEEQ 116
L Q I + QET QKL D E A L K A L E E Q
Sbjct: 1166 ---GGSSLA----QLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQ 1218
Query: 117 ALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEV------TT 170
E Q V QK +K++ +LQ+++ DL+T + R + T
Sbjct: 1219 V---------------ENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTL 1263
Query: 171 LKEKLHKSHT---RYTEESNSKEKEIENLKNLVAEFESRLKKE---IDSNDSVSENLRKE 224
+E+LH++ + T+ +N + L + EF RL+++ I+ N ++
Sbjct: 1264 YEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQ 1323
Query: 225 MEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLE 283
+E +L++ +Q+ L ++Q + L+E E E + EL LS+ ++++
Sbjct: 1324 IEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQ 1382
Score = 53.5 bits (127), Expect = 3e-07
Identities = 60/276 (21%), Positives = 129/276 (46%), Gaps = 26/276 (9%)
Query: 25 TVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQK--SIEQLQE 82
T+ + E ++ R+ N ++ T+ L + +E + L+ E M +++ + S+E+ +
Sbjct: 1372 TLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARH 1431
Query: 83 TLRQKL---LSDDNWKEKIEAELAKERAQH---LVEFEEQALLFKEETKLQLDIEKEKHQ 136
L+ +L LSD A L +++ Q L +++++ EE++ LD +++
Sbjct: 1432 QLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQK----HEESQALLDASQKE-- 1485
Query: 137 DVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENL 196
+Q E +L+ + I G LR+E L+E++ + T E E+E +
Sbjct: 1486 --VQALSTELLKLKNTYEESIVGQ-ETLRRENKNLQEEI-SNLTNQVREGTKNLTEMEKV 1541
Query: 197 KNLVAEFESRLKKEIDSNDSVSE-------NLRKEMEQKSDELKRVMLAQTQLIEQFNQS 249
K L+ E ++ ++ ++ + E + + E+ + EL+R + + + IE F +
Sbjct: 1542 KKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRK 1601
Query: 250 QE-ENTFLQETVRRECEERFELTEALSQAREQLLEL 284
Q+ LQ ++ E + R E+T + E L E+
Sbjct: 1602 QQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEM 1637
Score = 50.1 bits (118), Expect = 3e-06
Identities = 74/306 (24%), Positives = 134/306 (43%), Gaps = 54/306 (17%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
+K+ + L Q+ L+E++ V E RR +L ++ELE ++L QT
Sbjct: 1662 IKDLQMQLDDSTQLNSDLKEQVAVAE-------RRNSLLQSELEDLRSLQEQTERG--RR 1712
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAK------ERAQHLVEFEEQ 116
+E EL+ + + ++ Q T LLS K+K+EA++A+ E Q EE+
Sbjct: 1713 LSEEELLEATERINLFYTQNT---SLLSQ---KKKLEADVARMQKEAEEVVQECQNAEEK 1766
Query: 117 ALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLH 176
A E L E +K QD I ++ +E ++ I+DL Q+ E++
Sbjct: 1767 AKKAAIEAA-NLSEELKKKQDTIAHLERTRENMEQTITDL---------QKRLAEAEQMA 1816
Query: 177 KSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLR------KEME-QKS 229
+R K+I+ L++ V E E L+ EI + R KE+ Q
Sbjct: 1817 LMGSR---------KQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAE 1867
Query: 230 DELKRVMLAQTQL------IEQFNQSQE-ENTFLQETVRRECEERFELTEALSQAREQLL 282
++ K + QTQ+ ++ + Q E T + + + +++ EL E +A
Sbjct: 1868 EDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAES 1927
Query: 283 ELSKLR 288
+++KL+
Sbjct: 1928 QVNKLK 1933
Score = 44.7 bits (104), Expect = 1e-04
Identities = 70/296 (23%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 13 CQQIYKALQEELTVKEKQEEDIK-RRINLAENELEITKTLLNQTREEVLTLKNERELMLI 71
C Q+ KAL++ E Q E++K ++++L + + ++ L Q +E L E+ LI
Sbjct: 868 CAQLQKALEKS----EFQREELKAKQVSLTQEKNDLILQL--QAEQETLANVEEQCEWLI 921
Query: 72 SHQKSIEQLQETLRQKLLSDDNWKEKIEAEL-AKERAQHLVEFEEQALLFKEETKLQLDI 130
+ +E + L +++ + E+I +EL A+ R FE + + ET L +
Sbjct: 922 KSKIQLEARVKELSERVEEE----EEINSELTARGRKLEDECFELKKEIDDLETML-VKS 976
Query: 131 EKEKH--QDVIQKYKKEQEELQMKISDLITGAT----------RDLRQEVTTLKEKLHKS 178
EKEK + ++ +E E L IS L A DL E L L K+
Sbjct: 977 EKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSS-LSKA 1035
Query: 179 HTRYTEESNSKEKEIENLKNLVAEFESRLKK---EIDSNDSVSENLRKEMEQKSDELKRV 235
+ + ++ + E +E + E L K + N ENL ++EL++
Sbjct: 1036 NLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Query: 236 MLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
L +Q+ + + LQ+TV+ + +L E L R ++ + R L
Sbjct: 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADL 1151
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/257 (21%), Positives = 120/257 (46%), Gaps = 42/257 (16%)
Query: 46 EITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIE--AELA 103
E ++ LL+ +++EV L E + ++++SI QETLR++ + N +E+I
Sbjct: 1473 EESQALLDASQKEVQALSTELLKLKNTYEESIVG-QETLRRE---NKNLQEEISNLTNQV 1528
Query: 104 KERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD 163
+E ++L E E+ L +EE K ++ + E+ + +++ + + Q+ +
Sbjct: 1529 REGTKNLTEMEKVKKLIEEE-KTEVQVTLEETEGALERNESKILHFQL-----------E 1576
Query: 164 LRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN----LVAEFESRLKKEIDSNDSVSE 219
L + L+ KL + K++EIEN + + +S L E S V+
Sbjct: 1577 LLEAKAELERKL-----------SEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVT- 1624
Query: 220 NLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTE------A 273
L+K+ME+ +E++ + + + + +S + + ++ + ++ +L A
Sbjct: 1625 RLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVA 1684
Query: 274 LSQAREQLL--ELSKLR 288
+++ R LL EL LR
Sbjct: 1685 VAERRNSLLQSELEDLR 1701
Score = 42.7 bits (99), Expect = 6e-04
Identities = 61/249 (24%), Positives = 113/249 (45%), Gaps = 26/249 (10%)
Query: 104 KERAQHLVEFEEQALLFKEETKL-QLDIEKEKHQDVIQKYKKEQEELQ--MKISDLITGA 160
KE L + E++ +EE K Q+ + +EK+ D+I + + EQE L + + + +
Sbjct: 865 KEECAQLQKALEKSEFQREELKAKQVSLTQEKN-DLILQLQAEQETLANVEEQCEWLIKS 923
Query: 161 TRDLRQEVTTLKEKLHKS---HTRYTEESNSKEKEIENLKNLVAEFESRL---KKEIDSN 214
L V L E++ + ++ T E E LK + + E+ L +KE +
Sbjct: 924 KIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTT 983
Query: 215 DSVSENLRKEMEQKSDEL-------KRVMLAQTQLIEQFNQSQEENTFLQETVRRECEER 267
+ +NL +E+E ++++ K V A Q ++ + +E+ + L + + ++
Sbjct: 984 EHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQV 1043
Query: 268 FELTEALSQAREQLL----ELSKLRGSLPFSPCSLSK-GSLTSPAAAVSNHGERSLARLN 322
EL AL Q R+ + EL KL G+L + S+ S A E L+++N
Sbjct: 1044 DELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMN 1103
Query: 323 S----EKGI 327
S EKG+
Sbjct: 1104 SKVENEKGL 1112
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 65.1 bits (157), Expect = 1e-10
Identities = 74/266 (27%), Positives = 128/266 (48%), Gaps = 35/266 (13%)
Query: 34 IKRRINLAENELEITKTLLNQTREEV----LTLKNE---------RELMLISHQKSIEQL 80
+K RI + E E K+LL+Q +EE+ L L NE R++ L S +
Sbjct: 420 LKMRIEVLEKE----KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLN 475
Query: 81 QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQ 140
E Q+L + KE + AE+ + Q+ E + +L K+ QL ++ + +I
Sbjct: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQ-EATKHMILIKD----QLSKQQNEGDSIIS 530
Query: 141 KYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLV 200
K K++ + + ++ L D+ +E+ KEKL +S + +K+K + ++NLV
Sbjct: 531 KLKQDLNDEKKRVHQL-EDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLV 589
Query: 201 AEFESRLKKEIDSNDSVSE---NLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQ 257
+L K +SN S+ + L++ + Q +EL R+ Q + Q + S ++T L+
Sbjct: 590 ----DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
Query: 258 ETVRRECEERFELTEALSQAREQLLE 283
E RE E R L + LS+ EQL E
Sbjct: 646 E---REAEVR-NLKQNLSEL-EQLNE 666
Score = 63.5 bits (153), Expect = 3e-10
Identities = 75/274 (27%), Positives = 118/274 (43%), Gaps = 55/274 (20%)
Query: 52 LNQTREEVLTLKNER-ELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHL 110
L ++ EVL+ +E + L +KS+++ T+R ++ + I A ER +H
Sbjct: 1330 LRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH- 1388
Query: 111 VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRD------- 163
E+T ++ KEK QDV+QK KE++ L SD + + +
Sbjct: 1389 -----------EQTDSEIKQLKEK-QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE 1436
Query: 164 ---LRQEVTTLKE----------KLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLK-K 209
LRQ VT LKE KL + + E KE E + L+ +F L+ K
Sbjct: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
Query: 210 EIDSNDSVS-----ENLRKEMEQ-KSDELKRVMLA--------------QTQLIEQFNQS 249
E + + E L KE EQ K+ EL +++ A + Q++ Q
Sbjct: 1497 EFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK 1556
Query: 250 QEENTFLQETVRRECEERFELTEALSQAREQLLE 283
Q ENT LQ V+R ++ F + L + R LLE
Sbjct: 1557 QMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
Score = 57.4 bits (137), Expect = 2e-08
Identities = 67/274 (24%), Positives = 123/274 (44%), Gaps = 30/274 (10%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAE--NELEITKTLLNQTREEVL 60
LKEK+D L Q++ K +++L +K K ++ + N NE E+ + + +E +L
Sbjct: 1398 LKEKQDVL---QKLLK--EKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1452
Query: 61 TL-------KNERELMLISH---QKSIEQLQET-------LRQKLLSDDNWKEKIEA--E 101
L K E E ++ ++ + + LQET LR+K + KEK A +
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
Query: 102 LAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEE---LQMKISDLIT 158
L KE+ Q Q L + + + + +++ V+ K++Q E LQ ++ L
Sbjct: 1513 LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD 1572
Query: 159 GATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVS 218
R QE+ L+ L +S YT E+ + E L+ V E +L ++ ++ S
Sbjct: 1573 KEFRS-NQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENAS 1631
Query: 219 ENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEE 252
++E ++L V + + Q + SQE+
Sbjct: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQ 1665
Score = 51.2 bits (121), Expect = 2e-06
Identities = 67/307 (21%), Positives = 143/307 (46%), Gaps = 47/307 (15%)
Query: 1 MLLKEKEDSLMTCQQIYKALQEELTVKEKQE---EDIKRRINLAENELEITKTLLNQTRE 57
M+L+EKE + ++ KAL E +KEK++ ++ + +N ++ E T + Q R+
Sbjct: 1491 MMLREKEFECHSMKE--KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT-VVFQQERD 1547
Query: 58 EVLTLKNERELMLISHQKSIEQLQ----------ETLRQKLL-SDDNW-KEKIEAELAKE 105
+V+ ++++ + Q +++L+ E LR LL S+D++ +E + AE +
Sbjct: 1548 QVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREA 1607
Query: 106 RAQHLVEFEEQALLFK----EETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGAT 161
+ + V E+ L+ E Q ++ E Q+ + K+++E +++S +
Sbjct: 1608 KLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLS----VSQ 1663
Query: 162 RDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENL 221
++Q +L EE E+E K L+AE++ +ENL
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKN-----------AENL 1712
Query: 222 RKE---MEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
+ +++ DE + + ++L EQ + +E+ E ++R+ E R E+ L +
Sbjct: 1713 EGKVISLQECLDEANAALDSASRLTEQLDVKEEQ----IEELKRQNELRQEM---LDDVQ 1765
Query: 279 EQLLELS 285
++L+ L+
Sbjct: 1766 KKLMSLA 1772
Score = 50.4 bits (119), Expect = 3e-06
Identities = 74/351 (21%), Positives = 141/351 (40%), Gaps = 92/351 (26%)
Query: 15 QIYKALQEELTVKEKQEED----IKRRINLAENELEITKTLLNQTREEVLTLKNERELML 70
Q+ + + E T K +Q ED I ++++ AEN+ +I + Q E + E E +
Sbjct: 295 QVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLK 354
Query: 71 ISHQK----------SIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
+ K ++ + + L Q ++ ++ + A+ L + L
Sbjct: 355 LECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLA 414
Query: 121 KEETKLQLDIEK-EKHQDVIQKYKKEQEELQMKISD----LITGATRDLRQEVTTLKEKL 175
++ KL++ IE EK + ++ + K+E + +K+++ + + ATRD+ +L +L
Sbjct: 415 EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDI-----SLDSEL 469
Query: 176 HKSHTRYTEESNSKEKEIENLKNLVAEFES-----------------RLKKEIDSNDSVS 218
H + + I + L+AE E +L K+ + DS+
Sbjct: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSII 529
Query: 219 ENLRKEMEQKSDELKRV-------------------MLAQTQ------------------ 241
L++++ +DE KRV L Q++
Sbjct: 530 SKLKQDL---NDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE 586
Query: 242 -LIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSL 291
L++Q N+SQE N +Q +E EL E + Q E ELS++R L
Sbjct: 587 NLVDQLNKSQESNVSIQ-------KENLELKEHIRQNEE---ELSRIRNEL 627
Score = 49.7 bits (117), Expect = 5e-06
Identities = 52/251 (20%), Positives = 115/251 (45%), Gaps = 32/251 (12%)
Query: 52 LNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWK----EKIEAELAKERA 107
+N+ EV L++E + H + I Q + Q + D + + I EL + R+
Sbjct: 174 INRLSNEVSRLESE-----VGHWRHIAQTSKA--QGTDNSDQSEICKLQNIIKELKQNRS 226
Query: 108 QHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQE 167
Q + + + + + + + +L +H++ + Y++ EEL+ + G + + +
Sbjct: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ---GGSGVIETD 283
Query: 168 VTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQ 227
++ + E + K+ E K++E L++ + + + K++ S ++ + LR+E EQ
Sbjct: 284 LSKIYE-MQKTIQVLQIEKVESTKKMEQLEDKIKD----INKKLSSAENDRDILRREQEQ 338
Query: 228 KSDELKRVM-----------LAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQ 276
+ E +++M Q ++Q + E+ L ++ EE F L +ALS
Sbjct: 339 LNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRLQQALSD 396
Query: 277 AREQLLELSKL 287
A +++ LS L
Sbjct: 397 AENEIMRLSSL 407
Score = 48.9 bits (115), Expect = 8e-06
Identities = 74/281 (26%), Positives = 131/281 (46%), Gaps = 28/281 (9%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
++EK+ SL + ++ LQEEL E+ E+ R +A+ + + T L ++ T+
Sbjct: 848 IEEKDRSLGSMKEENNHLQEEL---ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTI 904
Query: 63 KNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKE 122
K E + HQK IE ++ Q L S K+ E+ + R QH EQ
Sbjct: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK----EMDEFRYQH-----EQMNATHT 955
Query: 123 ETKLQLDIEKEKHQDVIQKYK----KEQEELQMKISDLITGA-TRDLRQEVTTLKEKLHK 177
+ L+ D E + Q I++ K +E++++Q SD+ + L E + K L K
Sbjct: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSK 1015
Query: 178 SHTRYTEESNSKEKEIENLKNLVAEFESRLKKEID--SNDSVSENLRKEMEQKSDELKRV 235
+ T + KE+E+E L+ E L K+ID S D V + L + ++QK E++
Sbjct: 1016 AETERLVK-GIKERELE--IKLLNEKNISLTKQIDQLSKDEVGK-LTQIIQQKDLEIQ-- 1069
Query: 236 MLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQ 276
A I + +Q+ +LQ+ ++ ER ++ L++
Sbjct: 1070 --ALHARISSTSHTQDV-VYLQQQLQAYAMEREKVFAVLNE 1107
Score = 43.1 bits (100), Expect = 4e-04
Identities = 66/311 (21%), Positives = 135/311 (43%), Gaps = 51/311 (16%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKR---RINLAENELEITKTLLNQTREE 58
LLKE+E + + L++ L+ E+ E++K+ + + +L + + EE
Sbjct: 643 LLKEREAEV-------RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEE 695
Query: 59 VLTLKNEREL-------MLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERA---- 107
L N+ L L + IE +++LL + N EK EL+ R
Sbjct: 696 CLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTS 755
Query: 108 ------QHLVEFEEQALLFKEETKL---QLDIEKEKHQDVIQKYKKEQEELQMKISDLIT 158
+HL++ ++ + E K Q+D + ++ +DV+ +EQ++L I+
Sbjct: 756 ALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN---- 811
Query: 159 GATRDLRQE--VTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDS 216
++E + LKE+ K + S + K E L+ + E + L + N+
Sbjct: 812 ------KKEIFIEKLKERSSKLQEELDKYSQALRKN-EILRQTIEEKDRSLGSMKEENNH 864
Query: 217 VSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEE----NTFLQETVRRECEERFELTE 272
+ E L + E++S + +A + ++ + E NT ++E + E + ++ E
Sbjct: 865 LQEELERLREEQS---RTAPVADPKTLDSVTELASEVSQLNT-IKEHLEEEIKHHQKIIE 920
Query: 273 ALSQAREQLLE 283
+Q++ QLL+
Sbjct: 921 DQNQSKMQLLQ 931
Score = 37.7 bits (86), Expect = 0.018
Identities = 55/276 (19%), Positives = 115/276 (41%), Gaps = 32/276 (11%)
Query: 42 ENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQET-LRQKLLSDDNWKEKIEA 100
E EL ++T + +L +NER L + + + E ++Q+ S N ++ E
Sbjct: 46 EAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEV 105
Query: 101 ELAKERAQH------LVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKIS 154
E++ +A+ L++ + A + I + + M
Sbjct: 106 EISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFG 165
Query: 155 DLITGATR--DLRQEVTTLKEKL-HKSHTRYTEES----NSKEKEIENLKNLVAEFESRL 207
D+I+ L EV+ L+ ++ H H T ++ NS + EI L+N++ E +
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNR 225
Query: 208 KKEIDSN------------DSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTF 255
+EID + ++E R+ E+ SD +R+ + L++Q E
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELE-NLLQQGGSGVIETDL 284
Query: 256 -----LQETVRRECEERFELTEALSQAREQLLELSK 286
+Q+T++ E+ E T+ + Q +++ +++K
Sbjct: 285 SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINK 320
Score = 35.0 bits (79), Expect = 0.12
Identities = 56/285 (19%), Positives = 127/285 (44%), Gaps = 28/285 (9%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEV-------LTLKNERELMLIS 72
LQ++L + E + +N E KT ++ + V + L++E + +
Sbjct: 1087 LQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTR 1146
Query: 73 HQKSIEQL-QETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIE 131
+ S + + +ET++ LS ++ IE + ++ Q L+ + + E + +
Sbjct: 1147 FESSGQDMFRETIQN--LSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQF 1204
Query: 132 KE--KHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSK 189
+E + +D +++ K+ EE + ++ + ++++ E L+E+LH+ + +S++
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTV----QNMQHESAQLQEELHQLQAQVLVDSDNN 1260
Query: 190 EKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN-- 247
K + L+ +E N++ +N +E+ Q + ++ + L+ + +
Sbjct: 1261 SKLQVDYTGLIQSYE--------QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDII 1312
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQL-LELSKLRGSL 291
Q + L EC R +E LS++ E L EL +LR SL
Sbjct: 1313 SPQLSSASLLTPQSAEC-LRASKSEVLSESSELLQQELEELRKSL 1356
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 65.1 bits (157), Expect = 1e-10
Identities = 61/307 (19%), Positives = 141/307 (45%), Gaps = 23/307 (7%)
Query: 5 EKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTL--LNQTREEVLT- 61
+K+ + + + + +E +++ EK+ ED+ +I E E + L N T +E +T
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ 579
Query: 62 ----LKNERELMLISHQKSIEQLQE------TLRQKLLSDDNWKEKIEAEL--AKERAQH 109
LKN+ E + + +Q+QE + ++LS + ++ ++L +KE+
Sbjct: 580 LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639
Query: 110 L---VEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQEELQMKIS---DLITGATRD 163
L ++ + + LL E K + + H D Q +++++ KI+ D +T +D
Sbjct: 640 LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699
Query: 164 LRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAE-FESRLKKEIDSND-SVSENL 221
++ + L+ L + +Y E+ +K L A+ E + KE D L
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
Query: 222 RKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQL 281
++E ++ EL + + + +++ ++ + E+++++ ++ E + L Q E L
Sbjct: 760 NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 282 LELSKLR 288
+ +K++
Sbjct: 820 SQETKIQ 826
Score = 63.5 bits (153), Expect = 3e-10
Identities = 62/279 (22%), Positives = 126/279 (45%), Gaps = 19/279 (6%)
Query: 12 TCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLI 71
TC+++ LQ ++ K+++++K+ + + K LN +E+++ +N L
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT----LK 948
Query: 72 SHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKL--QLD 129
++K +QLQ + + S + K++IEA + + L + E + L ++ T+ +L
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 130 IEKEKHQDVIQKYKKEQEELQMKISDLITGATRDL--RQEVTTLKEKLHKSHTRYTEESN 187
EKEK + Y+K QE + SD + L RQ++ +++EKL + E+
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ----EDLI 1064
Query: 188 SKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFN 247
S +I N L+ E ++ + + L++ + D K L + +L+
Sbjct: 1065 SNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN--- 1121
Query: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
E + L E +C + E+T+ + + LE K
Sbjct: 1122 ----EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Score = 60.5 bits (145), Expect = 3e-09
Identities = 64/299 (21%), Positives = 130/299 (43%), Gaps = 23/299 (7%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAEN---ELEITKTLLNQTREEV 59
L++K++ + K +E+ E++ E+++ +I E E++ +K Q ++
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ 756
Query: 60 LTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALL 119
L + EL K +E +E + L E +E+ Q L + EE+ +
Sbjct: 757 RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI-----KQKLTKQEEEKQI 811
Query: 120 FKEETKLQLDIEKEKHQDV---IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLH 176
K++ + K +H+++ IQ E ++++M+ L+T E++T+K+KL
Sbjct: 812 LKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT--------ELSTVKDKLS 863
Query: 177 KSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVM 236
K + EKE + K + + E K+ EN KE ++ L++
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 237 LAQTQLIEQFNQSQEENTFLQETVRRECEERFEL----TEALSQAREQLLELSKLRGSL 291
A QL + N QE+ Q T+++ +E +L E + ++ ++ L+G L
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Score = 55.5 bits (132), Expect = 8e-08
Identities = 58/295 (19%), Positives = 124/295 (42%), Gaps = 30/295 (10%)
Query: 2 LLKEKEDSLMT-CQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL 60
L ++K L T I EE +++E E+ + R EL T++ + E+L
Sbjct: 160 LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR----LTEELNKEATVIQDLKTELL 215
Query: 61 TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF 120
++ ++ +K + Q+Q + L + EK++ E K ++Q+
Sbjct: 216 QRPGIEDVAVL--KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS-------- 265
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHT 180
E T QL E K + Y +E ++L+ +++L Q+ TL E L K
Sbjct: 266 -EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT--------QKNQTLTENLLKKEQ 316
Query: 181 RYTEESNSKEKEIENLKNLVAEFESR------LKKEIDSNDSVSENLRKEMEQKSDELKR 234
YT+ +E + KN+ A + L+ + ++++ + E+ +K + ++
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 235 VMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRG 289
+ +++ ++ + E LQ+ + + +L ++Q +LLE + G
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431
Score = 54.3 bits (129), Expect = 2e-07
Identities = 69/298 (23%), Positives = 131/298 (43%), Gaps = 32/298 (10%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTR---EEV 59
L E E + +K LQ++ KE+ ++ IN ++L T+ L + +E
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 60 LTLKNE----RELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEE 115
L +E +E + Q + +L+E L++K+ + +++ +L K + QH E+
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN----STELQHQLDKTKQQHQ---EQ 493
Query: 116 QALLFKEETKL---QLDIEKEKHQ--DVIQKYKKEQEELQMKISDLITGATRDLRQEVTT 170
QAL KL Q D+E+ Q D QK + + LQ ++ L +E
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL-----LEKERED 548
Query: 171 LKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD 230
L K+ T N +++ L+ V + +LK + +S+ ENL +++++
Sbjct: 549 LYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 231 ELK----RVMLAQT---QLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQL 281
L+ RV+ +T +L Q N+S+E+ + L ++ + E A + R L
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
Score = 52.4 bits (124), Expect = 7e-07
Identities = 63/279 (22%), Positives = 125/279 (44%), Gaps = 28/279 (10%)
Query: 18 KALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSI 77
K +Q L K+ + ++ R++ +E L L++ E LK E + +Q
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 78 EQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQD 137
+ ++ L+Q+ + ++++E+ + ++ L+E E Q K Q + EK D
Sbjct: 393 AEFKQ-LQQQREEKEQHGLQLQSEINQLHSK-LLETERQLGEAHGRLKEQRQLSSEKLMD 450
Query: 138 VIQKYKKEQE--ELQMKISDLITGATRDLRQEVTT---LKEKLHKSHTRYTEESNSKEKE 192
KEQ+ +LQ+K+S L L+++VT L+ +L K+ ++ E+ ++
Sbjct: 451 ------KEQQVADLQLKLSRL----EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 193 IENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQF------ 246
L+ + E L+ +I D +NL +++ + + + + L +
Sbjct: 501 TAKLREAQNDLEQVLR-QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559
Query: 247 ----NQSQEENTFLQETVRRECEERFELTEALSQAREQL 281
NQ QE+N LQE V + E+ +E+ QA+E L
Sbjct: 560 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL 598
Score = 51.2 bits (121), Expect = 2e-06
Identities = 67/312 (21%), Positives = 141/312 (45%), Gaps = 24/312 (7%)
Query: 14 QQIYKALQEELTVKEKQEEDIKRRINLAENELEITK----TLLNQTREEVLTLKNERELM 69
++I + + +L K + E IK+++ E E +I K TL +T+ + L N +
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 70 LISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLD 129
+ QK ++ +E L +L + + K+ L ++ EFE++ K LD
Sbjct: 838 VTELQK-VKMEKEALMTELSTVKDKLSKVSDSLKNSKS----EFEKENQKGKAAI---LD 889
Query: 130 IEKE----KHQDVIQKYK--KEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
+EK KHQ +Q KEQ+EL+ + + A+ L+ E+ +++E+L ++
Sbjct: 890 LEKTCKELKHQLQVQMENTLKEQKELKKSL-EKEKEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLI 243
+ EKE + L+ + E + +++ +++ L+ + QK++ ++ TQ
Sbjct: 949 QN----EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Query: 244 EQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSKGSL 303
++ +E+ + LQ + +E F+ ++ RE L ++ SL++ L
Sbjct: 1005 QELAAEKEKISVLQNNYEKS-QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 304 TSPAAAVSNHGE 315
S + N +
Sbjct: 1064 ISNRNQIGNQNK 1075
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/289 (21%), Positives = 130/289 (44%), Gaps = 31/289 (10%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLT 61
L++E + + T +Q +++L + K +DI++ +L E EL K+ L + E
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE---- 1131
Query: 62 LKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERA-QHLVEFEEQALLF 120
+ +K I +L E L+ L ++ KE + AK+ Q +E + +A
Sbjct: 1132 -------IKCRQEKEITKLNEELKSHKL--ESIKEITNLKDAKQLLIQQKLELQGKA--- 1179
Query: 121 KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKE------K 174
+ K ++ EK Q + + KKE+EEL+ + + +++++ +K+ K
Sbjct: 1180 -DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
Query: 175 LHKSHTRYTEESNSKEKEIENLKNLVAEFESR---LKKEIDSNDSVSENLRKE----MEQ 227
L T E + +KE ++ + V+E E + L+ EI ++ +N + E +E+
Sbjct: 1239 LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLER 1298
Query: 228 KSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQ 276
+ QT+++E + +QE R + + T+AL++
Sbjct: 1299 CLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Score = 42.0 bits (97), Expect = 0.001
Identities = 66/330 (20%), Positives = 131/330 (39%), Gaps = 37/330 (11%)
Query: 3 LKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTL 62
L +KE + Q L+E+L K +++ +++ + + + + L T ++
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 63 KNERELMLISHQKSIEQLQ--ETLRQKLLSDDNWKEKIEAEL-AKERA--------QHLV 111
+N+ E +L +++Q E L QK + + EK +L AK +A L
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 112 E----FEEQALLFKEETKLQLDIEKEKHQ---DVIQKYKKEQEELQMKISDLITGATRDL 164
E +EQ E+ K Q + K+ + D +Q+ K Q ++ L T + +L
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET-SVNEL 626
Query: 165 RQEVTTLKEK--------------LHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKE 210
++ KEK L + T + + ++ +N + + + L K
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 211 IDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFEL 270
D V+ L+ + E S +L+ + + Q EE L+ +++ + E+
Sbjct: 687 TTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYLSLEQKTEE---LEGQIKKLEADSLEV 742
Query: 271 TEALSQAREQLLELSKLRGSLPFSPCSLSK 300
+ QA + L + +L L LSK
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSK 772
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 65.1 bits (157), Expect = 1e-10
Identities = 71/270 (26%), Positives = 120/270 (44%), Gaps = 15/270 (5%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQ 79
LQ L EK EDI+ + L E + L N+ +EE+ L+ E H +I
Sbjct: 508 LQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPH--NIVS 565
Query: 80 LQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLD-IEKEKHQDV 138
L E ++ LSD + E E +E+ +H+ EE +L K E + ++ + HQ
Sbjct: 566 LMEKEKELALSDLR-RIMAEKEALREKLEHI---EEVSLFGKSELEKTIEHLTCVNHQLE 621
Query: 139 IQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKN 198
+KY+ + + L MK + I L+ + S + T E NS E L+
Sbjct: 622 SEKYELKSKVLIMK--ETIESLENKLKVQAQKFSHVAGDSSHQKT-EVNSLRIVNEQLQR 678
Query: 199 LVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQS----QEENT 254
V +++ RL + +S + K +E+K DEL M +Q + ++ +E
Sbjct: 679 SVDDYQHRLSIKRGELESAQAQI-KILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKD 737
Query: 255 FLQETVRRECEERFELTEALSQAREQLLEL 284
FLQETV + E+ L E L+ + + ++
Sbjct: 738 FLQETVDEKTEKIANLQENLANKEKAVAQM 767
Score = 55.8 bits (133), Expect = 6e-08
Identities = 87/368 (23%), Positives = 160/368 (43%), Gaps = 96/368 (26%)
Query: 2 LLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTRE-EVL 60
LL+ ++ + QQ LQE+L + E D ++I L E E+E L+ R +VL
Sbjct: 198 LLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVL 257
Query: 61 TL--KNERELMLISH---------------QKSIEQL---QETLRQKLLSDDNWKEKIEA 100
+L +N+ LI+H +K I +L +ET+ ++++ N EK+
Sbjct: 258 SLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQ 317
Query: 101 ELAK--ERAQHLVEFEEQAL-----------------------LFKEETKLQLDI----- 130
EL + + AQ L +E+ L L + KLQL++
Sbjct: 318 ELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQK 377
Query: 131 EKEKHQD----------VIQKYKKEQEELQMKISDLITGATRDLRQEVTTLK-----EKL 175
EKE+ D V+ + ++E++ L K+ R L EV ++ ++
Sbjct: 378 EKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV-TERQLTLEVERMRLEHGIKRR 436
Query: 176 HKSHTR-------YTEESNSKEKEIENLKNLV------AEFESRLKKEI----DSNDSVS 218
+S +R EE + +KE+E L++++ + +R K I + D S
Sbjct: 437 DRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNS 496
Query: 219 ENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAR 278
E ++ ++ DEL+R ++E+F + E+ +Q V+ ER +L+ ++A+
Sbjct: 497 E--IHQITRERDELQR-------MLERFEKYMED---IQSNVKLLTAERDKLSVLYNEAQ 544
Query: 279 EQLLELSK 286
E+L L K
Sbjct: 545 EELSALRK 552
Score = 44.7 bits (104), Expect = 1e-04
Identities = 59/271 (21%), Positives = 119/271 (43%), Gaps = 45/271 (16%)
Query: 20 LQEELTVKEKQEEDIKRRINLAENEL-EITKTLLNQTREEVLTLKNERELMLISHQKSIE 78
LQE L KEK +K I+ E+ + ++ +TL+N+ RE
Sbjct: 753 LQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDRE--------------------- 791
Query: 79 QLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDI-----EKE 133
+LR++L D KE E ++E + FKE +LQ D+ E +
Sbjct: 792 --INSLRRQL--DAAHKELDEVGRSRE------------IAFKENRRLQDDLATMARENQ 835
Query: 134 KHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEI 193
+ ++ +E+EE++ ++ IT +R + + KEK ++ + +++ ++
Sbjct: 836 EISLELEAAVQEKEEMKSRVHKYITEVSR--WESLMAAKEKENQDLLDRFQMLHNRAEDW 893
Query: 194 ENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEEN 253
E + S ++ E+ S D+ +LR+ +E E++ + A Q + +
Sbjct: 894 EVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAM 953
Query: 254 TFLQETVRRECEERFELTEALSQAREQLLEL 284
+ L+E +R + +E+ + LS RE ++L
Sbjct: 954 SRLEEELRHQEDEKATVLNDLSSLRELCIKL 984
Score = 42.0 bits (97), Expect = 0.001
Identities = 61/286 (21%), Positives = 123/286 (43%), Gaps = 34/286 (11%)
Query: 13 CQQIYKALQEELTVKEKQEEDIKRRINLAENEL-------EITKTLLNQTREEVLTLKNE 65
C+ L+E L ++++ ++R+++ A EL EI + ++++ T+ E
Sbjct: 774 CESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARE 833
Query: 66 RELMLISHQKSIEQLQETLRQ--KLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEE 123
+ + + + ++++ +E + K +++ + E + A KE L F Q L + E
Sbjct: 834 NQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRF--QMLHNRAE 891
Query: 124 TKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYT 183
D E + HQ + E +++++ + T R LR+ V E L K +
Sbjct: 892 -----DWEVKAHQ-----AEGESSSVRLELLSIDT-ERRHLRERV----ELLEKEIQEHI 936
Query: 184 EESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLR--KEMEQKSDELKRVMLAQTQ 241
++ E +I ++ ++ E L+ + D +V +L +E+ K D K +M TQ
Sbjct: 937 NAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIM---TQ 993
Query: 242 LIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKL 287
+ N E E V+ E + L + LS R + L L
Sbjct: 994 QLNSKNLEFERVVVELENVKSESD---LLKKQLSNERHTVKNLESL 1036
Score = 37.7 bits (86), Expect = 0.018
Identities = 58/282 (20%), Positives = 119/282 (42%), Gaps = 40/282 (14%)
Query: 15 QIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQ 74
++Y L + ++ +++K + E K L NQ ++ L+ E + +
Sbjct: 84 ELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESK----AKN 139
Query: 75 KSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEK 134
+ I+QLQE N ++ K+R+ + F Q ++ I++
Sbjct: 140 ERIQQLQEK---------NLHAVVQTPGGKKRS---IAFRRQ----------RMQIDEPV 177
Query: 135 HQDVIQKYKKEQEELQMKISDLITGAT---RDLRQEVTTLKEKLHKSHT---RYTEESNS 188
+ Y Q + I+DL+ A ++L+QEV L+EKL + Y+++
Sbjct: 178 PPSEVSSYPVPQPD-DPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIEL 236
Query: 189 KEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQ 248
+E+EIE L + S ++S + +E L + + D L++ + I + +
Sbjct: 237 REREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELME 296
Query: 249 SQEENTF-------LQETVRRECEERFELTEALSQAREQLLE 283
++E T E + +E E +L + L + +E++LE
Sbjct: 297 TKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLE 338
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,764,357
Number of Sequences: 37866
Number of extensions: 684509
Number of successful extensions: 10910
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 300
Number of HSP's successfully gapped in prelim test: 1139
Number of HSP's that attempted gapping in prelim test: 4779
Number of HSP's gapped (non-prelim): 4225
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.