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Search of human proteins with 133908623
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|133908623 protein kinase C, iota [Homo sapiens]
(596 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|133908623 protein kinase C, iota [Homo sapiens] 1239 0.0
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 876 0.0
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 628 e-180
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 628 e-180
gi|4885563 protein kinase C, epsilon [Homo sapiens] 407 e-113
gi|28557781 protein kinase C, eta [Homo sapiens] 392 e-109
gi|4506067 protein kinase C, alpha [Homo sapiens] 373 e-103
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 369 e-102
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 367 e-101
gi|13384594 protein kinase C, gamma [Homo sapiens] 350 2e-96
gi|47157325 protein kinase C, delta [Homo sapiens] 341 1e-93
gi|31377782 protein kinase C, delta [Homo sapiens] 341 1e-93
gi|5453976 protein kinase C, theta [Homo sapiens] 336 3e-92
gi|4502023 AKT2 kinase [Homo sapiens] 325 6e-89
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 313 2e-85
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 313 2e-85
gi|62241015 AKT1 kinase [Homo sapiens] 313 3e-85
gi|62241013 AKT1 kinase [Homo sapiens] 313 3e-85
gi|62241011 AKT1 kinase [Homo sapiens] 313 3e-85
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 304 1e-82
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 304 1e-82
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 303 3e-82
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 302 5e-82
gi|5453974 protein kinase N2 [Homo sapiens] 300 3e-81
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 294 2e-79
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 294 2e-79
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 294 2e-79
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 294 2e-79
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 277 2e-74
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 277 2e-74
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 1239 bits (3205), Expect = 0.0
Identities = 596/596 (100%), Positives = 596/596 (100%)
Query: 1 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 60
MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
Sbjct: 1 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 60
Query: 61 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 120
DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
Sbjct: 61 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 120
Query: 121 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 180
DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
Sbjct: 121 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 180
Query: 181 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 240
KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
Sbjct: 181 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 240
Query: 241 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 300
ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
Sbjct: 241 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 300
Query: 301 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 360
TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
Sbjct: 301 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 360
Query: 361 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 420
EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
Sbjct: 361 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 420
Query: 421 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 480
APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
Sbjct: 421 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 480
Query: 481 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 540
IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
Sbjct: 481 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 540
Query: 541 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
Sbjct: 541 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 876 bits (2264), Expect = 0.0
Identities = 429/589 (72%), Positives = 493/589 (83%), Gaps = 17/589 (2%)
Query: 18 GSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDP 77
GSG +VR+KA+Y GDI IT + + +FE LC EVRDMC + T+KW+D EGDP
Sbjct: 11 GSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDP 67
Query: 78 CTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYC 137
CTVSSQ+ELEEAFRL +D L+IHVFP PE+PG+PCPGEDKSIYRRGARRWRKLY
Sbjct: 68 CTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYR 127
Query: 138 ANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS--- 194
ANGH FQAKRFNRRA+C C++RIWGL RQGY+CINCKLLVHK+CH LV + C +H
Sbjct: 128 ANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSV 187
Query: 195 LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASS 247
+P QEP P+D + +D I Y SS H+S+ E+ K ++ + K S
Sbjct: 188 MPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQ 245
Query: 248 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 307
LGLQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFE
Sbjct: 246 GLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFE 305
Query: 308 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 367
QAS++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN
Sbjct: 306 QASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALN 365
Query: 368 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 427
+LHERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRG
Sbjct: 366 FLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRG 425
Query: 428 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 487
E+YGFSVDWWALGVLMFEMMAGRSPFDI+ +DNPD NTEDYLFQVILEK IRIPR LSV
Sbjct: 426 EEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 488 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEF 547
KA+ VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++
Sbjct: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543
Query: 548 GLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
GLDNFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 628 bits (1620), Expect = e-180
Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)
Query: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250
QEP P+D + +D I Y SS H+S+ E+ K ++ + K S LG
Sbjct: 8 QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65
Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
GFSVDWWALGVLMFEMMAGRSPFDI+ +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 628 bits (1620), Expect = e-180
Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)
Query: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250
QEP P+D + +D I Y SS H+S+ E+ K ++ + K S LG
Sbjct: 8 QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65
Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
GFSVDWWALGVLMFEMMAGRSPFDI+ +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 407 bits (1047), Expect = e-113
Identities = 222/503 (44%), Positives = 298/503 (59%), Gaps = 62/503 (12%)
Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG--------- 191
H F + C C +WGL RQG +C CK+ VH++C V CG
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302
Query: 192 -----------------RHSL--PQEPVMPMDQSSMHSDHAQTVIPYNPSSHE------- 225
R L E P SS + P +P E
Sbjct: 303 LADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENN 362
Query: 226 -----SLDQVGEEKEA--------MNTRESGKA----SSSLGLQDFDLLRVIGRGSYAKV 268
S D GEE A M+ E+G+ + LGL +F+ ++V+G+GS+ KV
Sbjct: 363 IRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKV 422
Query: 269 LLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRL 328
+L LK D +YA+KV+KK+++ D+D+D TEK + A HP+L L+ CFQT+ RL
Sbjct: 423 MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482
Query: 329 FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDS 388
FFV+EYVNGGDLMF +QR RK E +RFY+AE++ AL +LH+ G+IYRDLKLDN+LLD+
Sbjct: 483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA 542
Query: 389 EGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA 448
EGH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ +YG SVDWWALGVLM+EMMA
Sbjct: 543 EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 602
Query: 449 GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC- 507
G+ PF+ +DN ED LF+ IL + P LS +A S+LK+F+ K+P +RLGC
Sbjct: 603 GQPPFE----ADN-----EDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCV 653
Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
Q G I+ HPFF+ +DW ++EQK++ PPFKP I + ++NFD FT E LT D
Sbjct: 654 ASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVD 713
Query: 568 DDIVRKIDQSEFEGFEYINPLLM 590
+ IV++I+Q EF+GF Y LM
Sbjct: 714 EAIVKQINQEEFKGFSYFGEDLM 736
Score = 65.9 bits (159), Expect = 1e-10
Identities = 29/66 (43%), Positives = 44/66 (66%), Gaps = 2/66 (3%)
Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWG-LGRQGYKCINCKLLVHKKCHK 184
R+GA R R+++ NGH F A + +C+ C D IWG +G+QGY+C C +VHK+CH+
Sbjct: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
Query: 185 LVTIEC 190
L+ +C
Sbjct: 215 LIITKC 220
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 392 bits (1006), Expect = e-109
Identities = 197/449 (43%), Positives = 272/449 (60%), Gaps = 13/449 (2%)
Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200
H F + C C +WG+ RQG +C CK+ VH +C V CG +++
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305
Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
+ + M S +L + G+E +S+ LG+ +F+ +RV+
Sbjct: 306 L----AGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVL 361
Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
G+GS+ KV+L R+K+T +YA+KV+KK+++ D+D++ TEK + A NHPFL L
Sbjct: 362 GKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFC 421
Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
CFQT RLFFV+E+VNGGDLMFH+Q+ R+ E ARFY+AEI AL +LH++GIIYRDLK
Sbjct: 422 CFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLK 481
Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
LDNVLLD EGH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ YG +VDWWA+G
Sbjct: 482 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMG 541
Query: 441 VLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKD 500
VL++EM+ G +PF + ED LF+ IL ++ P L A +LKSF+ K+
Sbjct: 542 VLLYEMLCGHAPF---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKN 592
Query: 501 PKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEP 560
P RLG Q G I HPFF+ +DW + +Q+ PPF+P I + NFD F E
Sbjct: 593 PTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 652
Query: 561 VQLTPDDDDIVRKIDQSEFEGFEYINPLL 589
LTP D+ + I+Q EF F Y++P L
Sbjct: 653 PVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
Score = 60.1 bits (144), Expect = 6e-09
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 1/59 (1%)
Query: 133 RKLYCANGHTFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTIEC 190
R+++ NGH F A + +C+ C + IWG+ G+QGY+C C +VHK+CH L+ C
Sbjct: 164 RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTAC 222
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 373 bits (957), Expect = e-103
Identities = 182/367 (49%), Positives = 247/367 (67%), Gaps = 17/367 (4%)
Query: 221 PSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY 280
P+ ++ + + K+ N + K L DF+ L V+G+GS+ KV+L K T+ +Y
Sbjct: 312 PAGNKVISPSEDRKQPSNNLDRVK------LTDFNFLMVLGKGSFGKVMLADRKGTEELY 365
Query: 281 AMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDL 340
A+K++KK++V D+D++ EK V PFL LHSCFQT RL+FV+EYVNGGDL
Sbjct: 366 AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL 425
Query: 341 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMC 400
M+H+Q+ K E A FY+AEIS+ L +LH+RGIIYRDLKLDNV+LDSEGHIK+ D+GMC
Sbjct: 426 MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC 485
Query: 401 KEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSD 460
KE + G TT TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF
Sbjct: 486 KEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF------- 538
Query: 461 NPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
D ED LFQ I+E + P+SLS +A S+ K + K P +RLGC P+ G D++ H
Sbjct: 539 --DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHA 595
Query: 521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 580
FFR +DW+ +E +++ PPFKP + G+ G +NFD FT LTP D ++ IDQS+FE
Sbjct: 596 FFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFE 654
Query: 581 GFEYINP 587
GF Y+NP
Sbjct: 655 GFSYVNP 661
Score = 69.3 bits (168), Expect = 9e-12
Identities = 28/65 (43%), Positives = 41/65 (63%)
Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
R+GA R + ++ H F A+ F + C+ CTD IWG G+QG++C C +VHK+CH+
Sbjct: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
Query: 186 VTIEC 190
VT C
Sbjct: 82 VTFSC 86
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 8/75 (10%)
Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
CPG DK R + H F+ + C C ++GL QG KC C +
Sbjct: 86 CPGADKGPDTDDPR--------SKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137
Query: 177 LVHKKCHKLVTIECG 191
VHK+C V CG
Sbjct: 138 NVHKQCVINVPSLCG 152
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 369 bits (947), Expect = e-102
Identities = 175/343 (51%), Positives = 238/343 (69%), Gaps = 11/343 (3%)
Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
L DF+ L V+G+GS+ KV+L K TD +YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
PFL LHSCFQT RL+FV+EYVNGGDLM+H+Q+ + E HA FY+AEI++ L +L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
+GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+S+S +A
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPKSMSKEAV 569
Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
++ K + K P +RLGC P+ G DI+ H FFR +DW+ +E+K++ PP+KP G +
Sbjct: 570 AICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAE 627
Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAE 593
NFD FT P LTP D +++R IDQSEFEGF ++N + E
Sbjct: 628 NFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
Score = 73.2 bits (178), Expect = 6e-13
Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)
Query: 116 PCPGEDKSIY--RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCIN 173
P GE+ ++ R+GA R + ++ H F A+ F + C+ CTD IWG G+QG++C
Sbjct: 10 PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
Query: 174 CKLLVHKKCHKLVTIEC 190
C +VHK+CH+ VT C
Sbjct: 70 CCFVVHKRCHEFVTFSC 86
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 8/75 (10%)
Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
CPG DK R + H F+ ++ C C ++GL QG KC C +
Sbjct: 86 CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
Query: 177 LVHKKCHKLVTIECG 191
VHK+C V CG
Sbjct: 138 NVHKRCVMNVPSLCG 152
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 367 bits (943), Expect = e-101
Identities = 172/337 (51%), Positives = 235/337 (69%), Gaps = 10/337 (2%)
Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
L DF+ L V+G+GS+ KV+L K TD +YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
PFL LHSCFQT RL+FV+EYVNGGDLM+H+Q+ + E HA FY+AEI++ L +L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
+GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+S+S +A
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPKSMSKEAV 569
Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
++ K + K P +RLGC P+ G DI+ H FFR +DW+ +E+K++ PP+KP +
Sbjct: 570 AICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS 628
Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
NFD +FT +PV+LTP D + +DQ+EF GF Y NP
Sbjct: 629 NFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665
Score = 73.2 bits (178), Expect = 6e-13
Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)
Query: 116 PCPGEDKSIY--RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCIN 173
P GE+ ++ R+GA R + ++ H F A+ F + C+ CTD IWG G+QG++C
Sbjct: 10 PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
Query: 174 CKLLVHKKCHKLVTIEC 190
C +VHK+CH+ VT C
Sbjct: 70 CCFVVHKRCHEFVTFSC 86
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 8/75 (10%)
Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
CPG DK R + H F+ ++ C C ++GL QG KC C +
Sbjct: 86 CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
Query: 177 LVHKKCHKLVTIECG 191
VHK+C V CG
Sbjct: 138 NVHKRCVMNVPSLCG 152
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 350 bits (898), Expect = 2e-96
Identities = 171/350 (48%), Positives = 235/350 (67%), Gaps = 16/350 (4%)
Query: 243 GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTE 302
G + L + DF L V+G+GS+ KV+L + +D +YA+K++KK+++ D+D+D E
Sbjct: 340 GASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVE 399
Query: 303 KHVFEQASNHP-----FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARF 357
K V P FL LHS FQT RL+FV+EYV GGDLM+H+Q+ K E HA F
Sbjct: 400 KRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAF 459
Query: 358 YSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP 417
Y+AEI++ L +LH +GIIYRDLKLDNV+LD+EGHIK+TD+GMCKE + PG TT TFCGTP
Sbjct: 460 YAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTP 519
Query: 418 NYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 477
+YIAPEI+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+
Sbjct: 520 DYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF---------DGEDEEELFQAIMEQ 570
Query: 478 QIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVP 537
+ P+SLS +A ++ K FL K P +RLG P G I+ H FFR +DW+ +E+ ++ P
Sbjct: 571 TVTYPKSLSREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPP 629
Query: 538 PFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
PF+P G G +NFD FT LTP D ++ IDQ++F+GF Y+NP
Sbjct: 630 PFRPRPCGRSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
Score = 71.2 bits (173), Expect = 2e-12
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 107 PCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGR 166
P V + G P P R+GA R + ++ H F A+ F + C+ CTD IWG+G+
Sbjct: 6 PGVGDSEGGPRP----LFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGK 61
Query: 167 QGYKCINCKLLVHKKCHKLVTIEC 190
QG +C C +VH++CH+ VT EC
Sbjct: 62 QGLQCQVCSFVVHRRCHEFVTFEC 85
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 15/113 (13%)
Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
CPG K R N H F+ ++ C C ++GL QG KC C++
Sbjct: 85 CPGAGKGPQTDDPR--------NKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEM 136
Query: 177 LVHKKCHKLVTIECG------RHSLPQEPVMP-MDQSSMHSDHAQTVIPYNPS 222
VH++C + V CG R L E P D+ + A+ +IP +P+
Sbjct: 137 NVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPN 189
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 341 bits (874), Expect = 1e-93
Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)
Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199
H F+ + C C +WGL +QG KC +C + VH KC + V CG L E
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
Query: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255
+ + Q +S SD A + E V E N+ GK SS + +F
Sbjct: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350
Query: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315
+V+G+GS+ KVLL LK +A+K +KK++V D+D++ EK V A+ +PFL
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
Query: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375
L FQT+ LFFV+E++NGGDLM+H+Q + + A FY+AEI L +LH +GII
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
Query: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435
YRDLKLDNVLLD +GHIK+ D+GMCKE + STFCGTP+YIAPEIL+G Y FSVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
Query: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495
WW+ GVL++EM+ G+SPF + ED LF+ I PR ++ ++ +L+
Sbjct: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
Query: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555
++P +RLG TG +I+ HPFF+ ++W ++E++++ PPF+P + NFD +
Sbjct: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
Query: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
F NE +L+ D +++ +DQS F GF ++NP
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Score = 63.5 bits (153), Expect = 5e-10
Identities = 26/65 (40%), Positives = 36/65 (55%)
Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
RRGA + K++ H F A F + C++C D +WGL +QGYKC C +HKKC
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
Query: 186 VTIEC 190
+ C
Sbjct: 204 IIGRC 208
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 341 bits (874), Expect = 1e-93
Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)
Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199
H F+ + C C +WGL +QG KC +C + VH KC + V CG L E
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
Query: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255
+ + Q +S SD A + E V E N+ GK SS + +F
Sbjct: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350
Query: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315
+V+G+GS+ KVLL LK +A+K +KK++V D+D++ EK V A+ +PFL
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
Query: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375
L FQT+ LFFV+E++NGGDLM+H+Q + + A FY+AEI L +LH +GII
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
Query: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435
YRDLKLDNVLLD +GHIK+ D+GMCKE + STFCGTP+YIAPEIL+G Y FSVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
Query: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495
WW+ GVL++EM+ G+SPF + ED LF+ I PR ++ ++ +L+
Sbjct: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
Query: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555
++P +RLG TG +I+ HPFF+ ++W ++E++++ PPF+P + NFD +
Sbjct: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
Query: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
F NE +L+ D +++ +DQS F GF ++NP
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Score = 63.5 bits (153), Expect = 5e-10
Identities = 26/65 (40%), Positives = 36/65 (55%)
Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
RRGA + K++ H F A F + C++C D +WGL +QGYKC C +HKKC
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
Query: 186 VTIEC 190
+ C
Sbjct: 204 IIGRC 208
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 336 bits (862), Expect = 3e-92
Identities = 177/482 (36%), Positives = 259/482 (53%), Gaps = 49/482 (10%)
Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200
H F+ + C C +WGL RQG KC C + VH +C V CG +
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEA 291
Query: 201 MPMDQSSMHS------------------------DHAQTVIPYNPSSHE----------- 225
+ M +S+ + + A+ P E
Sbjct: 292 LAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLD 351
Query: 226 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 285
+D++ E +E L ++DF L +++G+GS+ KV L KKT++ +A+K +
Sbjct: 352 EVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKAL 411
Query: 286 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 345
KK++V D+D++ EK V A HPFL + FQT+ LFFV+EY+NGGDLM+H+Q
Sbjct: 412 KKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ 471
Query: 346 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR 405
K A FY+AEI L L +LH +GI+YRDLKLDN+LLD +GHIK+ D+GMCKE +
Sbjct: 472 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML 531
Query: 406 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQN 465
T+TFCGTP+YIAPEIL G+ Y SVDWW+ GVL++EM+ G+SPF
Sbjct: 532 GDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF---------HGQ 582
Query: 466 TEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 525
E+ LF I PR L +A +L ++P++RLG DI+ HP FR +
Sbjct: 583 DEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFREI 637
Query: 526 DWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585
+W+ +E+K++ PPF+P + F NFD +F NE +L+ D ++ +DQ+ F F ++
Sbjct: 638 NWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFM 697
Query: 586 NP 587
NP
Sbjct: 698 NP 699
Score = 60.5 bits (145), Expect = 4e-09
Identities = 25/65 (38%), Positives = 37/65 (56%)
Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
RRGA + K++ H F A F + C++C + +WGL +QGY+C C +HKKC
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
Query: 186 VTIEC 190
V +C
Sbjct: 205 VIAKC 209
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 325 bits (834), Expect = 6e-89
Identities = 165/362 (45%), Positives = 235/362 (64%), Gaps = 19/362 (5%)
Query: 231 GEEKEAMNTRES----GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVK 286
G ++ T E KA + + + DFD L+++G+G++ KV+LVR K T R YAMK+++
Sbjct: 125 GSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILR 184
Query: 287 KELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR 346
KE++ +++ TE V Q + HPFL L FQT RL FV+EY NGG+L FH+ R
Sbjct: 185 KEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
Query: 347 QRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP 406
+R EE ARFY AEI AL YLH R ++YRD+KL+N++LD +GHIK+TD+G+CKEG+
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
Query: 407 GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT 466
G T TFCGTP Y+APE+L DYG +VDWW LGV+M+EMM GR PF N D
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD--- 354
Query: 467 EDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVD 526
+ LF++IL ++IR PR+LS +A S+L L KDPK+RLG P ++ H FF +++
Sbjct: 355 HERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSIN 413
Query: 527 WDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD--DDI-VRKIDQ-SEFEGF 582
W + QK+++PPFKP ++ E FD +FT + + +TP D D + + ++DQ + F F
Sbjct: 414 WQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQF 473
Query: 583 EY 584
Y
Sbjct: 474 SY 475
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 313 bits (803), Expect = 2e-85
Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)
Query: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278
N S +D +GEE+ +A T K + DFD L+++G+G++ KV+LVR K + +
Sbjct: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338
YAMK++KKE++ +++ TE V + + HPFL L FQT+ RL FV+EYVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
Query: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398
+L FH+ R+R E+ RFY AEI AL+YLH I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
Query: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458
+CKEG+ T TFCGTP Y+APE+L DYG +VDWW LGV+M+EMM GR PF
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346
Query: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518
N D + LF++IL + I+ PR+LS A S+L L KDP +RLG P +I
Sbjct: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401
Query: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
H FF V+W + K++VPPFKP ++ E FD +FT + + +TP +
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 313 bits (803), Expect = 2e-85
Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)
Query: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278
N S +D +GEE+ +A T K + DFD L+++G+G++ KV+LVR K + +
Sbjct: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338
YAMK++KKE++ +++ TE V + + HPFL L FQT+ RL FV+EYVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
Query: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398
+L FH+ R+R E+ RFY AEI AL+YLH I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
Query: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458
+CKEG+ T TFCGTP Y+APE+L DYG +VDWW LGV+M+EMM GR PF
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346
Query: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518
N D + LF++IL + I+ PR+LS A S+L L KDP +RLG P +I
Sbjct: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401
Query: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
H FF V+W + K++VPPFKP ++ E FD +FT + + +TP +
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 313 bits (802), Expect = 3e-85
Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)
Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
K + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199
Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
V Q S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
E+L DYG +VDWW LGV+M+EMM GR PF N D + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369
Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
R+L +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428
Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
++ E FD +FT + + +T PD DD + +D + F F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 313 bits (802), Expect = 3e-85
Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)
Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
K + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199
Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
V Q S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
E+L DYG +VDWW LGV+M+EMM GR PF N D + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369
Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
R+L +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428
Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
++ E FD +FT + + +T PD DD + +D + F F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 313 bits (802), Expect = 3e-85
Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)
Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
K + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199
Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
V Q S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
E+L DYG +VDWW LGV+M+EMM GR PF N D + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369
Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
R+L +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428
Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
++ E FD +FT + + +T PD DD + +D + F F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 304 bits (779), Expect = 1e-82
Identities = 163/396 (41%), Positives = 233/396 (58%), Gaps = 31/396 (7%)
Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
+ MD SD P S ++ + +N SG + DFD L+VI
Sbjct: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168
Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
G+GS+ KVLL + K + YA+KV++K++V + ++ + E++V + HPFLVGLH
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
FQT +L+FV+++VNGG+L FH+QR+R PE ARFY+AEI+ AL YLH I+YRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
+N+LLDS GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y +VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
+++EM+ G PF D+ DN IL K + + +S+ A S+L+ L
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 396
Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
KD + RLG + F +IQ HPFF ++ W + QK++ PPF PN++G + NFD+ FT
Sbjct: 397 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454
Query: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
E V + D IV F GF Y P
Sbjct: 455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 304 bits (779), Expect = 1e-82
Identities = 163/396 (41%), Positives = 233/396 (58%), Gaps = 31/396 (7%)
Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
+ MD SD P S ++ + +N SG + DFD L+VI
Sbjct: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168
Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
G+GS+ KVLL + K + YA+KV++K++V + ++ + E++V + HPFLVGLH
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
FQT +L+FV+++VNGG+L FH+QR+R PE ARFY+AEI+ AL YLH I+YRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
+N+LLDS GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y +VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
+++EM+ G PF D+ DN IL K + + +S+ A S+L+ L
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 396
Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
KD + RLG + F +IQ HPFF ++ W + QK++ PPF PN++G + NFD+ FT
Sbjct: 397 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454
Query: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
E V + D IV F GF Y P
Sbjct: 455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 303 bits (776), Expect = 3e-82
Identities = 160/376 (42%), Positives = 230/376 (61%), Gaps = 27/376 (7%)
Query: 195 LPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDF 254
LP P +P M+S A T P PS +G A+ + DF
Sbjct: 48 LPVPPELPDHCYRMNSSPAGTPSP-QPSRANGNINLGPS-----------ANPNAQPTDF 95
Query: 255 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF 314
D L+VIG+G+Y KVLL + K YA+KV++K+ + ++ + E+ V + HPF
Sbjct: 96 DFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPF 155
Query: 315 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI 374
LVGL FQT +L+FV++YVNGG+L FH+QR+R+ E ARFY+AE++ A+ YLH I
Sbjct: 156 LVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNI 215
Query: 375 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 434
IYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y +V
Sbjct: 216 IYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAV 275
Query: 435 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK 494
DWW LG +++EM+ G PF S + Q +++ IL + ++IP +V A +L+
Sbjct: 276 DWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDLLQ 326
Query: 495 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS 554
S L+KD ++RLG + F +I+ H FF ++WD + K++ PPF PN++G L +FD
Sbjct: 327 SLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
Query: 555 QFTNEPVQ----LTPD 566
+FT E V TPD
Sbjct: 385 EFTQEAVSKSIGCTPD 400
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 302 bits (774), Expect = 5e-82
Identities = 147/318 (46%), Positives = 212/318 (66%), Gaps = 15/318 (4%)
Query: 253 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 312
DFD L+VIG+G+Y KVLL + K YA+KV++K+ + ++ + E+ V + H
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 313 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 372
PFLVGL FQT +L+FV++YVNGG+L FH+QR+R+ E ARFY+AE++ A+ YLH
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 373 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGF 432
IIYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 433 SVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASV 492
+VDWW LG +++EM+ G PF S + Q +++ IL + ++IP +V A +
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDL 264
Query: 493 LKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNF 552
L+S L+KD ++RLG + F +I+ H FF ++WD + K++ PPF PN++G L +F
Sbjct: 265 LQSLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 322
Query: 553 DSQFTNEPVQ----LTPD 566
D +FT E V TPD
Sbjct: 323 DPEFTQEAVSKSIGCTPD 340
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 300 bits (767), Expect = 3e-81
Identities = 158/389 (40%), Positives = 232/389 (59%), Gaps = 27/389 (6%)
Query: 200 VMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRV 259
++P QS D Q+ + Y+ E D+ +++ N LQDF V
Sbjct: 616 ILPKSQSEYKPDTPQSGLEYS-GIQELEDRRSQQRFQFN------------LQDFRCCAV 662
Query: 260 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVG 317
+GRG + KVLL K T+ ++A+K +KK + +++D + EK +FE ++ HPFLV
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
Query: 318 LHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYR 377
L +CFQT+ + FV+EY GGDLM H+ E A FY+A + L L YLHE I+YR
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
Query: 378 DLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWW 437
DLKLDN+LLD+EG +K+ D+G+CKEG+ GD TSTFCGTP ++APE+L Y +VDWW
Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
Query: 438 ALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
LGVL++EM+ G SPF + E+ +F I+ ++R PR LS +A S+++ L
Sbjct: 842 GLGVLIYEMLVGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
++P+ RLG + D++ HPFFR +DW + K+V PPF P I G + NFD +FT
Sbjct: 893 RRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951
Query: 558 NE-PVQLTPDDDDIVRKIDQSEFEGFEYI 585
+E P+ P + I+ + +Q F F+YI
Sbjct: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 294 bits (752), Expect = 2e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 123
Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 124 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 183
Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 184 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 243
Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 244 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 297
Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 298 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 352
Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 353 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 412
Query: 576 QS--EFEGFEYINP 587
++ F GF Y P
Sbjct: 413 EAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 294 bits (752), Expect = 2e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 78 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 137
Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 138 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 197
Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 198 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 257
Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 258 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 311
Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 312 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 366
Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 367 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 426
Query: 576 QS--EFEGFEYINP 587
++ F GF Y P
Sbjct: 427 EAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 294 bits (752), Expect = 2e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 151
Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 152 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 211
Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 212 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 271
Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 272 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 325
Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 326 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 380
Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 381 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 440
Query: 576 QS--EFEGFEYINP 587
++ F GF Y P
Sbjct: 441 EAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 294 bits (752), Expect = 2e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 218
Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 219 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 278
Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 279 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 338
Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 339 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 392
Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 393 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 447
Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 448 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 507
Query: 576 QS--EFEGFEYINP 587
++ F GF Y P
Sbjct: 508 EAAEAFLGFSYAPP 521
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 277 bits (708), Expect = 2e-74
Identities = 150/379 (39%), Positives = 223/379 (58%), Gaps = 25/379 (6%)
Query: 221 PSSHESLDQVGEEKEA----MNTRES-GKA------SSSLGLQDFDLLRVIGRGSYAKVL 269
PSS SL +E A T+E+ G A S L L+DF L V+GRG + KVL
Sbjct: 577 PSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVL 636
Query: 270 LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVGLHSCFQTESR 327
L + + ++A+K +KK + ++++ + EK + ++ HPFLV L CFQT
Sbjct: 637 LSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEH 696
Query: 328 LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD 387
+ FV+EY GGDLM H+ E A FYSA + L L +LHE I+YRDLKLDN+LLD
Sbjct: 697 VCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD 755
Query: 388 SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM 447
+EG++K+ D+G+CKEG+ GD TSTFCGTP ++APE+L Y +VDWW LGVL++EM+
Sbjct: 756 TEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML 815
Query: 448 AGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507
G SPF + E+ +F I+ ++R PR LS +A +++ L ++P+ RLG
Sbjct: 816 VGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 866
Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE-PVQLTPD 566
+ D++ PFFR + W+ + +++ PPF P +SG + NFD +FT E P P
Sbjct: 867 SERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 925
Query: 567 DDDIVRKIDQSEFEGFEYI 585
D + +Q+ F F+++
Sbjct: 926 DARPLTAAEQAAFLDFDFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 277 bits (708), Expect = 2e-74
Identities = 150/379 (39%), Positives = 223/379 (58%), Gaps = 25/379 (6%)
Query: 221 PSSHESLDQVGEEKEA----MNTRES-GKA------SSSLGLQDFDLLRVIGRGSYAKVL 269
PSS SL +E A T+E+ G A S L L+DF L V+GRG + KVL
Sbjct: 571 PSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVL 630
Query: 270 LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVGLHSCFQTESR 327
L + + ++A+K +KK + ++++ + EK + ++ HPFLV L CFQT
Sbjct: 631 LSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEH 690
Query: 328 LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD 387
+ FV+EY GGDLM H+ E A FYSA + L L +LHE I+YRDLKLDN+LLD
Sbjct: 691 VCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD 749
Query: 388 SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM 447
+EG++K+ D+G+CKEG+ GD TSTFCGTP ++APE+L Y +VDWW LGVL++EM+
Sbjct: 750 TEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML 809
Query: 448 AGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507
G SPF + E+ +F I+ ++R PR LS +A +++ L ++P+ RLG
Sbjct: 810 VGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 860
Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE-PVQLTPD 566
+ D++ PFFR + W+ + +++ PPF P +SG + NFD +FT E P P
Sbjct: 861 SERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 919
Query: 567 DDDIVRKIDQSEFEGFEYI 585
D + +Q+ F F+++
Sbjct: 920 DARPLTAAEQAAFLDFDFV 938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,376,014
Number of Sequences: 37866
Number of extensions: 1159884
Number of successful extensions: 5069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 2719
Number of HSP's gapped (non-prelim): 1074
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.