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Search of human proteins with 13376840
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13376840 WD repeat domain 61 [Homo sapiens]
(305 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13376840 WD repeat domain 61 [Homo sapiens] 629 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 129 4e-30
gi|113865883 WD repeat domain 38 [Homo sapiens] 122 5e-28
gi|16554629 WD repeat domain 5 [Homo sapiens] 118 6e-27
gi|16554627 WD repeat domain 5 [Homo sapiens] 118 6e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 108 5e-24
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 107 1e-23
gi|26665869 WD repeat domain 51B [Homo sapiens] 105 7e-23
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 104 9e-23
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 104 9e-23
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 104 1e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens] 103 2e-22
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 102 3e-22
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 102 3e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 102 6e-22
gi|19913369 transducin beta-like 3 [Homo sapiens] 101 7e-22
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 101 9e-22
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 100 2e-21
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 100 2e-21
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 100 3e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 5e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 5e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 5e-21
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 98 8e-21
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 98 1e-20
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 94 2e-19
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 93 3e-19
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 93 3e-19
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 93 3e-19
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 93 3e-19
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 629 bits (1622), Expect = 0.0
Identities = 305/305 (100%), Positives = 305/305 (100%)
Query: 1 MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL 60
MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL
Sbjct: 1 MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL 60
Query: 61 EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120
EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY
Sbjct: 61 EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120
Query: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG
Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF
Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
Query: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI
Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
Query: 301 YDCPI 305
YDCPI
Sbjct: 301 YDCPI 305
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 129 bits (323), Expect = 4e-30
Identities = 68/289 (23%), Positives = 137/289 (47%), Gaps = 5/289 (1%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
+ H + ++++A+ + + TGS D K+W + + GH +V +
Sbjct: 131 EGHRNVVYAIAFNN---PYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSF 185
Query: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
+ + A+ S+D +LWD++NG+++ ++ + +L+F+ + TG+ V +
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245
Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
+ ++G+K L I S +++ D + +G++D ++D GK + TL GH
Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
I F +L+ TAS DG +I+ L GH + ++F P H ++ SS
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
DK+ ++WD T C+ H D+++ +N G+ +++ D I+
Sbjct: 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 124 bits (312), Expect = 8e-29
Identities = 77/303 (25%), Positives = 152/303 (50%), Gaps = 9/303 (2%)
Query: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRD-ERLDLQWSL 60
+N LFK +AH + +VA ++ +TGS D K+W E L+ +L
Sbjct: 78 SNHTFYLFKVLKAHILPLTNVALN----KSGSCFITGSYDRTCKLWDTASGEELN---TL 130
Query: 61 EGHQLGVVSVDISHTL-PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ 119
EGH+ V ++ ++ A+ S D +LW +E GK + + L+F+P S
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
Query: 120 YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT 179
+ATG+ ++ +++G++ Y+L I+S++++ G + +G+ D + ++D T
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVA 239
G+ ++ L GH I S +F+ D L++T S D K++D + TL+GH +L+
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
F ++S+D + +++ TR C+ H+ ++ + +N G+ +++ D+
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 300 IYD 302
I+D
Sbjct: 371 IWD 373
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 122 bits (305), Expect = 5e-28
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 6/269 (2%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
+ + ++TGS D V W+ R +L W L GH V S + AS+S D +RL
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQL--LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
Query: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
WD+ K ++ + T++FSPDS+ LA+G +V ++ V+SG+ L
Sbjct: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDI--ATGKLLH-TLEGHAMPIRSLTFSPDSQLLVT 207
I S +SP LA+G+ D ++I+D+ T + H LEGH+ I L +S S LL +
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLAS 208
Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
S D I I+ ++L L GH +WV ++AF PD+ S+ + VKVWD T C+
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL 268
Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQ 296
T D + +G +VS DQ
Sbjct: 269 ETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Score = 95.9 bits (237), Expect = 4e-20
Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 11/176 (6%)
Query: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
V +V FG G+ + S A+SPDG+ L +G+ DG + ++ +G+LL L
Sbjct: 11 VRRVKFFGQHGGE-----------VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59
Query: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
GH P++ FSPD L +AS D ++++DV A L GH V V+F PD
Sbjct: 60 GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ 119
Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
S DK V +WDV + + H+D + ++ + + + D +HI+D
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Score = 90.1 bits (222), Expect = 2e-18
Identities = 58/192 (30%), Positives = 94/192 (48%), Gaps = 4/192 (2%)
Query: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
AFSPD Q L TG+ G V + SG+ + L + +SPDG AS + D +
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87
Query: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
++D+A K L L+GH + +++FSPDS+ L + D + ++DVQ + L GH
Sbjct: 88 RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
Query: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVG--TRTCVHTFFD-HQDQVWGVKYNGNGSKI 289
+ + F P + S D +V +WD+ T H + H + + Y+ +G +
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LL 206
Query: 290 VSVGDDQEIHIY 301
S D+ IHI+
Sbjct: 207 ASGSWDKTIHIW 218
Score = 79.0 bits (193), Expect = 5e-15
Identities = 54/226 (23%), Positives = 104/226 (46%), Gaps = 4/226 (1%)
Query: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
+ S D + W+ +G+ + + FSPD A+ + V ++ V K
Sbjct: 38 TGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKC 97
Query: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
L + + ++++SPD + LASG D + ++D+ +G++L L GH I+S FSP
Sbjct: 98 LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP 157
Query: 201 DSQLLVTASDDGYIKIYDVQHANLAGT---LSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
L T S D + I+D++ A + L GH++ + + + S S DK++
Sbjct: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIH 216
Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303
+W T + + H V + ++ + + S G + + ++DC
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDC 262
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 118 bits (296), Expect = 6e-27
Identities = 72/251 (28%), Positives = 130/251 (51%), Gaps = 4/251 (1%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
L+++L GH V SV S ASSS D I++W +GK K+I + +A+S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
DS L + + + I+ V SGK +L ++ ++P + SG+ D + I+
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
D+ TGK L TL H+ P+ ++ F+ D L+V++S DG +I+D TL +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
++ V F P+ + ++++ D ++K+WD C+ T+ H+++ + + N G IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 292 VGDDQEIHIYD 302
+D ++I++
Sbjct: 277 GSEDNLVYIWN 287
Score = 110 bits (276), Expect = 1e-24
Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 18/271 (6%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H A+ SV + N E + + S D L+K+W D + + ++ GH+LG+ V S
Sbjct: 44 HTKAVSSVKFSPN----GEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
+ S+S D +++WD+ +GK +K++ + F+P S + +G+ V I+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
V++GK +L + ++ ++ DG + S + DG+ I+D A+G+ L TL + P+
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
+ FSP+ + ++ A+ D +K++D T +GH N +C
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYCIFANFSVTGGKW 273
Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
VS S D V +W++ T+ V H D V
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Score = 71.6 bits (174), Expect = 8e-13
Identities = 51/199 (25%), Positives = 99/199 (49%), Gaps = 12/199 (6%)
Query: 27 NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDA 86
N S +V+GS D+ V++W + + +L H V +V + + SSS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 87 HIRLWDLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KE 141
R+WD +G+ +K++ D PV + FSP+ +Y+ T + ++ GK K
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Query: 142 YSLDTRGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
Y+ K+ + +S GK++ SG+ D ++ I+++ T +++ L+GH + S P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 201 DSQLLVTAS--DDGYIKIY 217
++ +A+ +D IK++
Sbjct: 312 TENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 118 bits (296), Expect = 6e-27
Identities = 72/251 (28%), Positives = 130/251 (51%), Gaps = 4/251 (1%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
L+++L GH V SV S ASSS D I++W +GK K+I + +A+S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
DS L + + + I+ V SGK +L ++ ++P + SG+ D + I+
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
D+ TGK L TL H+ P+ ++ F+ D L+V++S DG +I+D TL +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
++ V F P+ + ++++ D ++K+WD C+ T+ H+++ + + N G IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 292 VGDDQEIHIYD 302
+D ++I++
Sbjct: 277 GSEDNLVYIWN 287
Score = 110 bits (276), Expect = 1e-24
Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 18/271 (6%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H A+ SV + N E + + S D L+K+W D + + ++ GH+LG+ V S
Sbjct: 44 HTKAVSSVKFSPN----GEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
+ S+S D +++WD+ +GK +K++ + F+P S + +G+ V I+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
V++GK +L + ++ ++ DG + S + DG+ I+D A+G+ L TL + P+
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
+ FSP+ + ++ A+ D +K++D T +GH N +C
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYCIFANFSVTGGKW 273
Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
VS S D V +W++ T+ V H D V
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Score = 71.6 bits (174), Expect = 8e-13
Identities = 51/199 (25%), Positives = 99/199 (49%), Gaps = 12/199 (6%)
Query: 27 NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDA 86
N S +V+GS D+ V++W + + +L H V +V + + SSS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 87 HIRLWDLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KE 141
R+WD +G+ +K++ D PV + FSP+ +Y+ T + ++ GK K
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Query: 142 YSLDTRGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
Y+ K+ + +S GK++ SG+ D ++ I+++ T +++ L+GH + S P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 201 DSQLLVTAS--DDGYIKIY 217
++ +A+ +D IK++
Sbjct: 312 TENIIASAALENDKTIKLW 330
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 108 bits (271), Expect = 5e-24
Identities = 59/152 (38%), Positives = 88/152 (57%)
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
+ S+ +SP+G++LAS + D +I I+ GK TL GH + I + +S DS LV+ASD
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
D +K++DV+ TL GH+++V F P +S S D++VK+W+V T C+ T
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
H D V V +N +GS IVS D I+D
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 108 bits (270), Expect = 6e-24
Identities = 68/251 (27%), Positives = 127/251 (50%), Gaps = 4/251 (1%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
L+ +L GH V SV S ASSS D I +W +GK K++ ++ +A+S
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
DS L + + + ++ V SGK +L ++ ++P + SG+ D + I+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
++ TGK L TL H+ P+ ++ F+ L+V+ S DG +I+D TL +
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP 212
Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
++ V F P+ + ++++ D ++K+WD C+ T+ H+++ + + N G IVS
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 292 VGDDQEIHIYD 302
+D ++I++
Sbjct: 273 GSEDNLVYIWN 283
Score = 104 bits (260), Expect = 9e-23
Identities = 73/271 (26%), Positives = 129/271 (47%), Gaps = 18/271 (6%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H +A+ SV + N E + + S D L+ +W D + + +L GH L + V S
Sbjct: 40 HTEAVSSVKFSPN----GEWLASSSADRLIIIWGAYDGKYEK--TLYGHNLEISDVAWSS 93
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
S+S D ++LWD+ +GK +K++ + F+P S + +G+ V I+
Sbjct: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
V++GK +L + ++ ++ G + SG+ DG+ I+D A+G+ L TL + P+
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
+ FSP+ + ++TA+ D +K++D T +GH N +C
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK----NEKYCIFANFSVTGGKW 269
Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
VS S D V +W++ T+ V H D V
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/238 (28%), Positives = 115/238 (48%), Gaps = 13/238 (5%)
Query: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW------------TLAFSPDSQYLATGT 125
+A S DA +L + Q K + P A ++ FSP+ ++LA+ +
Sbjct: 1 MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSS 60
Query: 126 HVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185
+ I+G GK E +L I +A+S D L S + D + ++D+ +GK L T
Sbjct: 61 ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120
Query: 186 LEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
L+GH+ + F+P S L+++ S D +KI++V+ TLS H+ V V F +
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 246 HFVSSSSDKSVKVWDVGTRTCVHTFFDHQD-QVWGVKYNGNGSKIVSVGDDQEIHIYD 302
VS S D ++WD + C+ T D + V VK++ NG I++ D + ++D
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Score = 90.9 bits (224), Expect = 1e-18
Identities = 62/251 (24%), Positives = 124/251 (49%), Gaps = 12/251 (4%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H+ I VAW ++ S +V+ S D +K+W R + +L+GH V + +
Sbjct: 82 HNLEISDVAWSSD----SSRLVSASDDKTLKLWDVRSGKC--LKTLKGHSNYVFCCNFNP 135
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
+ S S D +++W+++ GK +K++ A + F+ + +G++ G I+
Sbjct: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Query: 135 VESGKKEYSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
SG+ +L D + + +SP+GKY+ + +D + ++D + G+ L T GH
Sbjct: 196 AASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEK 255
Query: 194 RSL--TFS-PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSS 250
+ FS + +V+ S+D + I+++Q + L GH V++ A P + S+
Sbjct: 256 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
Query: 251 S--SDKSVKVW 259
+ +DK++K+W
Sbjct: 316 ALENDKTIKLW 326
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/198 (25%), Positives = 101/198 (51%), Gaps = 12/198 (6%)
Query: 32 SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91
S +++GS D+ VK+W+ + + +L H V +V + + + S S D R+W
Sbjct: 137 SNLIISGSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 92 DLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDT 146
D +G+ +K++ D PV + FSP+ +Y+ T T + ++ G+ K Y+
Sbjct: 195 DAASGQCLKTLVDDDNPPVSF--VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
Query: 147 RGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLL 205
K+ + +S GK++ SG+ D ++ I+++ T +++ L+GH + S P L+
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312
Query: 206 VTAS--DDGYIKIYDVQH 221
+A+ +D IK++ H
Sbjct: 313 ASAALENDKTIKLWMSNH 330
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 107 bits (267), Expect = 1e-23
Identities = 66/289 (22%), Positives = 136/289 (47%), Gaps = 22/289 (7%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+V+ S D +KVW + E D + +L+GH V + H+ + AS S D I+LWD +
Sbjct: 123 MVSASEDATIKVWDY--ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
+ I+++ + ++A P+ ++ + + + ++ V++G + +++ +
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240
Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQ----------- 203
+ DG +AS + D + ++ +AT + L H + ++++P+S
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
Query: 204 ---------LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
L++ S D IK++DV TL GH +WV V F +S + DK
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303
+++VWD + C+ T H+ V + ++ +V+ DQ + +++C
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 100 bits (250), Expect = 1e-21
Identities = 52/162 (32%), Positives = 88/162 (54%)
Query: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS 199
++Y+L + + + P + S + D I ++D TG TL+GH ++ ++F
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159
Query: 200 PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
+LL + S D IK++D Q T+ GH V +VA P+ H VS+S DK++K+W
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 260 DVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
+V T CV TF H++ V V+ N +G+ I S +DQ + ++
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 99.8 bits (247), Expect = 3e-21
Identities = 60/266 (22%), Positives = 123/266 (46%), Gaps = 20/266 (7%)
Query: 57 QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP 116
+++L GH+ V V + S+S DA I++WD E G +++ ++F
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
+ LA+ + + ++ + + ++ + S+A P+G ++ S + D I +++
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 177 IATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVL 236
+ TG + T GH +R + + D L+ + S+D ++++ V L H V
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 237 NVAFCPDDTH--------------------FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQ 276
+++ P+ ++ +S S DK++K+WDV T C+ T H +
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
Query: 277 VWGVKYNGNGSKIVSVGDDQEIHIYD 302
V GV ++ G I+S DD+ + ++D
Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWD 366
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 105 bits (261), Expect = 7e-23
Identities = 58/192 (30%), Positives = 93/192 (48%)
Query: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
+L SP+ + LAT + + ++ + + Y + S+ +SP G LAS + D
Sbjct: 23 SLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDR 82
Query: 171 IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
+ ++ + H P+RS+ FS D Q L TAS+D IK++ + +L
Sbjct: 83 TVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR 142
Query: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
H WV F PD VS S DK++K+WD + CV+ F D V +N +G+ I
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 202
Query: 291 SVGDDQEIHIYD 302
S G DQ + ++D
Sbjct: 203 SAGSDQTVKVWD 214
Score = 100 bits (249), Expect = 2e-21
Identities = 69/295 (23%), Positives = 134/295 (45%), Gaps = 6/295 (2%)
Query: 7 ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
+L + + H AI S+ N K+ + T S D + +W ++ ++ GH+
Sbjct: 9 VLERYFKGHKAAITSLDLSPNGKQ----LATASWDTFLMLWNFKPHARAYRYV--GHKDV 62
Query: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
V SV S + AS+S D +RLW + + A ++ FS D Q+LAT +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
+ ++ + + YSL ++ +SPDG+ + S + D I I+D + ++
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Query: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
+ F+P + +A D +K++DV+ L H+ V ++F P +
Sbjct: 183 SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNY 242
Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
+++SSD ++K+ D+ ++T H V+ V ++ G S G D ++ ++
Sbjct: 243 LITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 100 bits (248), Expect = 2e-21
Identities = 62/247 (25%), Positives = 116/247 (46%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
L+ +GH+ + S+D+S A++S D + LW+ + + ++ FS
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
P LA+ + V ++ + K + S+ +S DG++LA+ + D I ++
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
+ + L++L H +R FSPD +L+V+ S+D IKI+D + S +
Sbjct: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDD 295
V F P T S+ SD++VKVWDV + + H V + ++ +G+ +++ D
Sbjct: 190 NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
Query: 296 QEIHIYD 302
+ I D
Sbjct: 250 GTLKILD 256
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 104 bits (260), Expect = 9e-23
Identities = 66/227 (29%), Positives = 107/227 (47%), Gaps = 16/227 (7%)
Query: 77 PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGV 135
P A SL+ H + G DA T FS +++ LA+G+ + ++ +
Sbjct: 4 PCAEDPSLERHFK---------------GHRDAVTCVDFSINTKQLASGSMDSCLMVWHM 48
Query: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
+ + Y + + +SP G LASG+ D + I+ H +RS
Sbjct: 49 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS 108
Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
+ F D Q VTASDD +K++ +LS H +WV F PD VS+S DK+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT 168
Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
VK+WD +R CVH++ +H V V ++ +G+ I + G D + ++D
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 103 bits (256), Expect = 2e-22
Identities = 65/289 (22%), Positives = 133/289 (46%), Gaps = 6/289 (2%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
+ H DA+ V + N K+ + +GS+D + VW + + +++ GH+ V V+
Sbjct: 16 KGHRDAVTCVDFSINTKQ----LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNF 69
Query: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
S + + AS S D +R+W + A ++ F D Q T + V +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
+ K +SL ++ +SPDG+ + S + D + ++D ++ + +H+ H
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
+ + F P + A D +K++DV+ L H++ V ++F P + +++SS
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
D ++K+ D+ ++T HQ V ++ G S G D+++ ++
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 100 bits (248), Expect = 2e-21
Identities = 66/248 (26%), Positives = 113/248 (45%), Gaps = 2/248 (0%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-F 114
L+ +GH+ V VD S AS S+D+ + +W ++ + G DA T F
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNF 69
Query: 115 SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
SP LA+G+ V I+ + + S+ + DG+ + + D + +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
+ K L +L H +R FSPD +L+V+ASDD +K++D + H +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294
V V F P T ++ D +VKVWDV T + + H V G+ ++ +G+ +++
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 295 DQEIHIYD 302
D + I D
Sbjct: 250 DSTLKILD 257
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 104 bits (260), Expect = 9e-23
Identities = 66/227 (29%), Positives = 107/227 (47%), Gaps = 16/227 (7%)
Query: 77 PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGV 135
P A SL+ H + G DA T FS +++ LA+G+ + ++ +
Sbjct: 4 PCAEDPSLERHFK---------------GHRDAVTCVDFSINTKQLASGSMDSCLMVWHM 48
Query: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
+ + Y + + +SP G LASG+ D + I+ H +RS
Sbjct: 49 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS 108
Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
+ F D Q VTASDD +K++ +LS H +WV F PD VS+S DK+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT 168
Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
VK+WD +R CVH++ +H V V ++ +G+ I + G D + ++D
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 103 bits (256), Expect = 2e-22
Identities = 65/289 (22%), Positives = 133/289 (46%), Gaps = 6/289 (2%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
+ H DA+ V + N K+ + +GS+D + VW + + +++ GH+ V V+
Sbjct: 16 KGHRDAVTCVDFSINTKQ----LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNF 69
Query: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
S + + AS S D +R+W + A ++ F D Q T + V +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
+ K +SL ++ +SPDG+ + S + D + ++D ++ + +H+ H
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
+ + F P + A D +K++DV+ L H++ V ++F P + +++SS
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
D ++K+ D+ ++T HQ V ++ G S G D+++ ++
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 100 bits (248), Expect = 2e-21
Identities = 66/248 (26%), Positives = 113/248 (45%), Gaps = 2/248 (0%)
Query: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-F 114
L+ +GH+ V VD S AS S+D+ + +W ++ + G DA T F
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNF 69
Query: 115 SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
SP LA+G+ V I+ + + S+ + DG+ + + D + +
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
+ K L +L H +R FSPD +L+V+ASDD +K++D + H +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294
V V F P T ++ D +VKVWDV T + + H V G+ ++ +G+ +++
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 295 DQEIHIYD 302
D + I D
Sbjct: 250 DSTLKILD 257
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 104 bits (259), Expect = 1e-22
Identities = 60/226 (26%), Positives = 107/226 (47%), Gaps = 11/226 (4%)
Query: 88 IRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
++L+DL +G +++IDA W+++ SPD + TG V + E K E S R
Sbjct: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKR 537
Query: 148 -----------GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSL 196
+ +L ++YSP+ K LA +D + IF + T K +L GH +P+ +
Sbjct: 538 LSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICM 597
Query: 197 TFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSV 256
S D L+ T S D +KI+ + + +L H V+ + F P F ++ D +
Sbjct: 598 DISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKI 657
Query: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
K WD + T H ++W + + +G +VS D+ + +++
Sbjct: 658 KQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 91.3 bits (225), Expect = 1e-18
Identities = 50/175 (28%), Positives = 87/175 (49%)
Query: 87 HIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
H+ +WDL G++I + + L SPD +LA G G + IF + SG+ + +
Sbjct: 46 HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
Query: 147 RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
I ++ Y G LASG+ D I ++D+ L+ L+GH I F + LLV
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
Query: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
T+ D +K +D+ + T+ GH + V + ++ ++ +SD ++VWD+
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 85.9 bits (211), Expect = 4e-17
Identities = 50/173 (28%), Positives = 82/173 (47%)
Query: 130 VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
V I+ + G+K L + + + SPDG +LA G DG I IF + +G+ T GH
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
Query: 190 AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVS 249
I +L + L + S D I ++DV + + L GH + F + V+
Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
Query: 250 SSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
S D VK WD+ T+ C T H+ +VWG+ ++++ D E+ ++D
Sbjct: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/223 (25%), Positives = 97/223 (43%), Gaps = 15/223 (6%)
Query: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---RDERLDLQWSLEG 62
G L + AHD A+WS++ +++ VTG D VK W + +DE Q L
Sbjct: 486 GNLLETIDAHDGALWSMSLSPDQRG----FVTGGADKSVKFWDFELVKDEN-STQKRLSV 540
Query: 63 HQL-------GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
Q V+ V S + A S LD ++++ ++ K S+ + + S
Sbjct: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
D +ATG+ V I+G++ G SL ++ + + P + D I +
Sbjct: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
D + + TLEGH I L SP +V++S D +++++
Sbjct: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 52.0 bits (123), Expect = 7e-07
Identities = 37/164 (22%), Positives = 74/164 (45%), Gaps = 11/164 (6%)
Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
++ L + P + + G G + ++D+A+G LL T++ H + S++ SPD + VT
Sbjct: 455 EYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTG 514
Query: 209 SDDGYIKIYDVQHANLAGTLSGHASW-----------VLNVAFCPDDTHFVSSSSDKSVK 257
D +K +D + + S VL V++ P+ S D +VK
Sbjct: 515 GADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVK 574
Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
++ V T + + H+ V + + +G+ I + D+ + I+
Sbjct: 575 IFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW 618
Score = 50.1 bits (118), Expect = 2e-06
Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 5/111 (4%)
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTAS 209
+ ++++S D + S A D I I++ +T + + T+ +A+ F P + +V +
Sbjct: 418 VRTLSFSSDNIAVLSAAADSI-KIWNRSTLQCIRTMTCEYAL---CSFFVPGDRQVVIGT 473
Query: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
G +++YD+ NL T+ H + +++ PD FV+ +DKSVK WD
Sbjct: 474 KTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Score = 33.1 bits (74), Expect = 0.31
Identities = 20/90 (22%), Positives = 41/90 (45%)
Query: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD 272
++ I+D++ L G V + PD H D S++++ + + TF
Sbjct: 46 HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
Query: 273 HQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
H+ + +KY+ G ++ S D +I ++D
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWD 135
Score = 33.1 bits (74), Expect = 0.31
Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 2/101 (1%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+ +GS D + VW +E + L+GH+ + + +S D ++ WDL+
Sbjct: 122 LASGSKDTDIIVWDVINE--SGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLD 179
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV 135
K++ + W L + + L TG ++ ++ +
Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 29.6 bits (65), Expect = 3.5
Identities = 32/130 (24%), Positives = 53/130 (40%), Gaps = 20/130 (15%)
Query: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPD 117
+ GH+ + ++ AS S D I +WD+ N + + G DA T A F +
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KGHKDAITQALFLRE 160
Query: 118 SQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF---------ILSIAYSPDGKYLASGAI 168
L T G ++ K + LDT+ F + + + K L +GA
Sbjct: 161 KNLLVTS---------GKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS 211
Query: 169 DGIINIFDIA 178
D + ++DIA
Sbjct: 212 DSELRVWDIA 221
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 103 bits (256), Expect = 2e-22
Identities = 64/246 (26%), Positives = 109/246 (44%), Gaps = 6/246 (2%)
Query: 19 IWSVA---WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWS-LEGHQLGVVSVDISH 74
+WSV + K+ + +++ DD+++ + DE+ + L GH V S
Sbjct: 496 VWSVTPKKLRSVKQASDLSLIDKESDDVLE--RIMDEKTASELKILYGHSGPVYGASFSP 553
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
SSS D +RLW L+ + W FSP Y +G H ++
Sbjct: 554 DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWA 613
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
+ + + + P+ Y+A+G+ D + ++D+ G + GH PI
Sbjct: 614 TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH 673
Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
SLTFSP+ + L T + DG + ++D+ H + G L GH V ++ F D S S D
Sbjct: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733
Query: 255 SVKVWD 260
+V++WD
Sbjct: 734 TVRLWD 739
Score = 91.7 bits (226), Expect = 7e-19
Identities = 62/275 (22%), Positives = 118/275 (42%), Gaps = 17/275 (6%)
Query: 30 ENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
++S + G D V+VW ++L SV + L + S D R
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLER 526
Query: 90 LWDLENGKQIKSI--DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
+ D + ++K + +GPV + +FSPD YL + + G V ++ +++
Sbjct: 527 IMDEKTASELKILYGHSGPV--YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH 584
Query: 148 GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVT 207
+ +SP G Y SG D + ++ + L GH + F P+S + T
Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVAT 644
Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
S D ++++DV + N +GH + ++ F P+ + ++D V +WD+G V
Sbjct: 645 GSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704
Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
H D V ++++ +G + S D + ++D
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 102 bits (255), Expect = 3e-22
Identities = 65/253 (25%), Positives = 117/253 (46%), Gaps = 6/253 (2%)
Query: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73
AH + S+ G K + + TG D V +W + SL GH V SV ++
Sbjct: 18 AHASNVSSLVLG---KASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLN 72
Query: 74 HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133
+ + S IR+WDLE K ++++ + +L F P +++A+G+ + ++
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
+ + + + + +SPDGK+LAS A D + ++D+ GK++ GH P+
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD 253
+ F P+ LL + S D I+ +D++ + + G V +V F PD S D
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Query: 254 KSVKVWDVGTRTC 266
S++V+ C
Sbjct: 253 -SLRVYGWEPERC 264
Score = 94.7 bits (234), Expect = 9e-20
Identities = 56/224 (25%), Positives = 104/224 (46%), Gaps = 1/224 (0%)
Query: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
+ A+ D + LW + I S+ ++ + + + G+ G + ++ +E+
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 138 GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197
K +L I S+ + P G+++ASG+ D I ++DI + GH+ +R L
Sbjct: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Query: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
FSPD + L +A+DD +K++D+ + GH V V F P++ S SSD++++
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
WD+ V V V +N +G + S G + +Y
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSLRVY 257
Score = 87.8 bits (216), Expect = 1e-17
Identities = 40/143 (27%), Positives = 77/143 (53%)
Query: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
G+ LA+G D +N++ I + +L GH P+ S+ + +L+V S G I+++D+
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG 279
+ A + TL GH + + ++ F P S S D ++K+WD+ + CV + H V
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 280 VKYNGNGSKIVSVGDDQEIHIYD 302
++++ +G + S DD + ++D
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWD 175
Score = 83.6 bits (205), Expect = 2e-16
Identities = 50/182 (27%), Positives = 86/182 (47%)
Query: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
LATG +VN++ + SL + S+ + + + +G+ G I ++D+
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
K+L TL GH I SL F P + + + S D IK++D++ GH+ V + F
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
Query: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
PD S++ D +VK+WD+ + F H V V+++ N + S D+ I
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 301 YD 302
+D
Sbjct: 216 WD 217
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 102 bits (255), Expect = 3e-22
Identities = 54/197 (27%), Positives = 102/197 (51%), Gaps = 5/197 (2%)
Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
+ + + DS+ L + + GK+ I+ + K +++ R ++++ AY+P G Y+A G +D
Sbjct: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLD 118
Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
I +I+++ T ++ L GH + F D+Q+ VT+S D ++D++
Sbjct: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQT 177
Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
T +GH V++++ PD FVS + D S K+WDV C TF H+ + + + N
Sbjct: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN 237
Query: 286 GSKIVSVGDDQEIHIYD 302
G+ + DD ++D
Sbjct: 238 GNAFATGSDDATCRLFD 254
Score = 82.4 bits (202), Expect = 5e-16
Identities = 58/250 (23%), Positives = 117/250 (46%), Gaps = 7/250 (2%)
Query: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
+L GH + ++ + S+S D + +WD ++ +I T A++P
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 119 QYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIF 175
Y+A G +I+ +++ G S + G LS D + + + D ++
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169
Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
DI TG+ T GH + SL+ +PD++L V+ + D K++DV+ T +GH S +
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229
Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNGSKIVSV 292
+ F P+ F + S D + +++D+ + T + H + + G V ++ +G +++
Sbjct: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMT-YSHDNIICGITSVSFSKSGRLLLAG 288
Query: 293 GDDQEIHIYD 302
DD +++D
Sbjct: 289 YDDFNCNVWD 298
Score = 81.6 bits (200), Expect = 8e-16
Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 5/230 (2%)
Query: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
V G LD++ ++ K R+ + + L GH + I SS D LWD
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWD 170
Query: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
+E G+Q + D +L+ +PD++ +G ++ V G + I
Sbjct: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN 230
Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL--EGHAMPIRSLTFSPDSQLLVTASD 210
+I + P+G A+G+ D +FD+ + L T + I S++FS +LL+ D
Sbjct: 231 AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
D ++D A+ AG L+GH + V + D + S D +K+W+
Sbjct: 291 DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 102 bits (253), Expect = 6e-22
Identities = 62/215 (28%), Positives = 98/215 (45%), Gaps = 7/215 (3%)
Query: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
S S D IR WDL + W L SP S Y A+G+H ++ + +
Sbjct: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD---R 415
Query: 141 EYSLDTRGKFILSI---AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197
Y L + + + P+ YLA+G+ D + ++ G + GH P+ SL
Sbjct: 416 TYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLA 475
Query: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
FSP+ + L +A +D +K++D+ L L GH + ++ F PD S+S D SV+
Sbjct: 476 FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVR 535
Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292
VWD+ C ++ GV Y G S ++SV
Sbjct: 536 VWDIRNTYCSAPADGSSSELVGV-YTGQMSNVLSV 569
Score = 80.1 bits (196), Expect = 2e-15
Identities = 59/274 (21%), Positives = 113/274 (41%), Gaps = 16/274 (5%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
+S+ + G + +K+W R ++L E HQ+ V + ++ + D
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKL----KSEPHQVDVSRIHLACDILEEEDDEDD----- 329
Query: 91 WDLENGKQIKSI--DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG 148
G ++K + GPV ++ F DS L + + + + + S
Sbjct: 330 ---NAGTEMKILRGHCGPV--YSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384
Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
+ + SP Y ASG+ D ++ L GH + + F P+S L T
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444
Query: 209 SDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVH 268
S D ++++ Q N +GH VL++AF P+ + S+ D+ +K+WD+ + T
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504
Query: 269 TFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
H D + + ++ + I S D + ++D
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 66.6 bits (161), Expect = 3e-11
Identities = 56/253 (22%), Positives = 97/253 (38%), Gaps = 47/253 (18%)
Query: 97 KQIKSIDAGPVDAWTLAF---------------SPDSQYLATGTHVGKVNIFGVESGK-- 139
+ IK + GP T+ F SPDS+ LA G + ++ + S K
Sbjct: 244 ESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLK 303
Query: 140 -----------------------KEYSLDTRGKF-------ILSIAYSPDGKYLASGAID 169
++ + T K + S + D L S + D
Sbjct: 304 SEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSED 363
Query: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229
I +D+ + +GHA P+ L SP S + S D +++ +
Sbjct: 364 MSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYA 423
Query: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKI 289
GH + V V F P+ + + S+DK+V++W V F H+ V + ++ NG +
Sbjct: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL 483
Query: 290 VSVGDDQEIHIYD 302
S G+DQ + ++D
Sbjct: 484 ASAGEDQRLKLWD 496
Score = 62.0 bits (149), Expect = 6e-10
Identities = 48/195 (24%), Positives = 83/195 (42%), Gaps = 13/195 (6%)
Query: 24 WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSS 83
W + S +GS D ++W + D L+ GH V V A+ S
Sbjct: 388 WDLDISPYSLYFASGSHDRTARLWSF-DRTYPLR-IYAGHLADVDCVKFHPNSNYLATGS 445
Query: 84 LDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYS 143
D +RLW + G ++ +LAFSP+ +YLA+ ++ ++ + SG
Sbjct: 446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKE 505
Query: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDI-----------ATGKLLHTLEGHAMP 192
L I S+ +SPD +AS ++D + ++DI ++ +L+ G
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565
Query: 193 IRSLTFSPDSQLLVT 207
+ S+ F + LLVT
Sbjct: 566 VLSVQFMACNLLLVT 580
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 101 bits (252), Expect = 7e-22
Identities = 73/265 (27%), Positives = 123/265 (46%), Gaps = 22/265 (8%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
VV S +KV++ + + L GH V+++D+ + AS + D +R+W +
Sbjct: 350 VVVASNSPCLKVFELQTSACQI---LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQ----YLATGTHVGKVNIFGVESG------------ 138
Q+ + G ++ S+ +L TG+ V ++ +
Sbjct: 407 KAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP 466
Query: 139 ---KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
+ + + K I S+A +P+ K LA+G+ D ++ + +LL GH +
Sbjct: 467 ILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWC 526
Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
+ FSP Q+L TAS DG IK++ +Q + T GH + VL VAF T +SS SD
Sbjct: 527 VQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGV 280
VK+W + CV T H+D+VWG+
Sbjct: 587 VKLWTIKNNECVRTLDAHEDKVWGL 611
Score = 69.3 bits (168), Expect = 4e-12
Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 9/189 (4%)
Query: 123 TGTHV-----GKVNIFGVESGKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIFD 176
TG H+ +VNI V SG SL+ + I + SPD + L + + ++ +
Sbjct: 35 TGQHLFCVCGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWA 94
Query: 177 IATGKLLHTLEG-HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
G + + H P+ ++ F P S LL T DG ++++D+ G V
Sbjct: 95 WQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVV 154
Query: 236 LNVAFCPDDTHFV--SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG 293
VAF PD T + SS++D +++VW + R+C+ H V + ++ +G ++S G
Sbjct: 155 HLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSG 214
Query: 294 DDQEIHIYD 302
D+ I+D
Sbjct: 215 RDKICIIWD 223
Score = 67.8 bits (164), Expect = 1e-11
Identities = 66/291 (22%), Positives = 124/291 (42%), Gaps = 29/291 (9%)
Query: 32 SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL----GVVSVDISHTLP---IAASSSL 84
S + TG D V+VW D+ H GVV + H P + SS+
Sbjct: 121 STLLATGGCDGAVRVW-------DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173
Query: 85 DAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK---- 140
DA IR+W L++ + + A +LAFS D + + I+ ++S +
Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTV 233
Query: 141 ------EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL---EGHAM 191
E ++ + + + G Y + G + +++ A+G+ ++T G
Sbjct: 234 PVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQ 293
Query: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-PDDTHFVSS 250
+ T + + +++TA+ D + +Y+ + L +G++ VL+V F P+D+H V +
Sbjct: 294 ELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA 353
Query: 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
S+ +KV+++ T C H D V + G S DQ + I+
Sbjct: 354 SNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
Score = 63.9 bits (154), Expect = 2e-10
Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 35/245 (14%)
Query: 41 DDLVKVWKWRDERLDL---QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGK 97
D V++W+ + Q S H +G V + S D ++LW L
Sbjct: 397 DQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKE-SFLVTGSQDCTVKLWPLPKAL 455
Query: 98 QIKSI--DAGPV-------------DAWTLAFSPDSQYLATGTH--------VGKVNIFG 134
K+ D GP+ D ++A +P+ + LATG+ + + + G
Sbjct: 456 LSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLG 515
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
V SG + RG + + +SP + LA+ + DG I ++ + L T EGH +
Sbjct: 516 VFSGHR------RG--LWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
+ F L+++ DG +K++ +++ TL H V + D H ++ +SD
Sbjct: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDS 627
Query: 255 SVKVW 259
V +W
Sbjct: 628 RVILW 632
Score = 61.2 bits (147), Expect = 1e-09
Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 12/182 (6%)
Query: 88 IRLWDLENGKQIKSIDA-GPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
+ + ++ +G ++S++ D SPD++ L T + + + +E S+
Sbjct: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRA----LLLAQWAWQEGSVTR 102
Query: 147 RGKFI-----LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201
K I ++A+ P LA+G DG + ++DI H G + + F PD
Sbjct: 103 LWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPD 162
Query: 202 SQ--LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
LL +++ D I+++ +Q + L+ H S V ++AF D +SS DK +W
Sbjct: 163 PTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIW 222
Query: 260 DV 261
D+
Sbjct: 223 DL 224
Score = 61.2 bits (147), Expect = 1e-09
Identities = 52/205 (25%), Positives = 82/205 (40%), Gaps = 14/205 (6%)
Query: 35 VVTGSLDDLVKVWKWRDE-------------RLDLQWSLEGHQLGVVSVDISHTLPIAAS 81
+VTGS D VK+W L Q + H + SV I+ + A+
Sbjct: 437 LVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLAT 496
Query: 82 SSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE 141
S D +LW L + + W + FSP Q LAT + G + ++ ++
Sbjct: 497 GSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556
Query: 142 YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP- 200
+ + +L +A+ G L S DG++ ++ I + + TL+ H + L S
Sbjct: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL 616
Query: 201 DSQLLVTASDDGYIKIYDVQHANLA 225
D L ASD I DV A A
Sbjct: 617 DDHALTGASDSRVILWKDVTEAEQA 641
Score = 48.9 bits (115), Expect = 6e-06
Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 8/169 (4%)
Query: 12 EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71
++ HD I SVA N K + TGS D K+W + L GH+ G+ V
Sbjct: 475 QRCHDKDINSVAIAPNDK----LLATGSQDRTAKLWAL--PQCQLLGVFSGHRRGLWCVQ 528
Query: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAF-SPDSQYLATGTHVGKV 130
S + A++S D I+LW L++ +K+ + +AF S +Q L++G+ G V
Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSD-GLV 587
Query: 131 NIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT 179
++ +++ + +LD + + S + +GA D + ++ T
Sbjct: 588 KLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVT 636
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 101 bits (251), Expect = 9e-22
Identities = 63/280 (22%), Positives = 127/280 (45%), Gaps = 11/280 (3%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIA--------ASS 82
NS+ + T L K+W D +L +L GH V ++ ++ AS
Sbjct: 242 NSKMLATACWSGLCKLWSVPD--CNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299
Query: 83 SLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY 142
+ D ++LW L++ + + I+ V + + P ++L T + ++ +E+ ++
Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
+ + IA+ DG +G +D ++D+ TG+ + LEGH I + FSP+
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
Query: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF-VSSSSDKSVKVWDV 261
+ T S D K++D++ T+ H + V V F P +F ++ + D + K+W
Sbjct: 420 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
Query: 262 GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
+ + T H+ +V G+ + +G I + D+ ++
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 87.0 bits (214), Expect = 2e-17
Identities = 51/196 (26%), Positives = 96/196 (48%), Gaps = 3/196 (1%)
Query: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
T++ P LA+ G V ++ ++S + ++ + + + P G++L + D
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345
Query: 171 IINIFDI-ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229
++D+ A ++LH EGH+M + + F D L T D + +++D++ L
Sbjct: 346 SWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404
Query: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG-NGSK 288
GH + + F P+ H + S D + KVWD+ R CV+T HQ+ V GVK+ +G+
Sbjct: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNF 464
Query: 289 IVSVGDDQEIHIYDCP 304
+++ D I+ P
Sbjct: 465 LLTGAYDNTAKIWTHP 480
Score = 59.7 bits (143), Expect = 3e-09
Identities = 36/155 (23%), Positives = 71/155 (45%), Gaps = 8/155 (5%)
Query: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL--------LVT 207
+SP+ K LA+ G+ ++ + LLHTL GH + ++ F P S + L +
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
+ DG +K++ + + GH V V + P ++ D+S ++WD+ + +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
H V+ + ++ +GS + G D ++D
Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 393
Score = 51.6 bits (122), Expect = 9e-07
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV--------LNVA 239
G PI FSP+S++L TA G K++ V NL TL GH + V V+
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
P D + S ++D SVK+W + + V H +V V ++ +G + + D+
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 300 IYD 302
++D
Sbjct: 349 LWD 351
Score = 32.0 bits (71), Expect = 0.70
Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 9/104 (8%)
Query: 24 WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPI----A 79
+G N N + TGS D+ KVW R R +++ HQ V V PI
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFE---PIHGNFL 465
Query: 80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLAT 123
+ + D ++W +K++ L S D Q +AT
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509
Score = 32.0 bits (71), Expect = 0.70
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 8/63 (12%)
Query: 35 VVTGSLDDLVKVWK---WRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91
++TG+ D+ K+W W + +L GH+ V+ +DIS + A+ S D +LW
Sbjct: 465 LLTGAYDNTAKIWTHPGWSPLK-----TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Query: 92 DLE 94
E
Sbjct: 520 MAE 522
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 100 bits (249), Expect = 2e-21
Identities = 55/190 (28%), Positives = 99/190 (52%), Gaps = 5/190 (2%)
Query: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
DS+ L + + GK+ I+ + K +++ R ++++ AY+P G Y+A G +D I +I++
Sbjct: 66 DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Query: 177 IATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
+ T ++ L GH + F DSQ+ VT+S D ++D++ A T +GH+
Sbjct: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHS 184
Query: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292
V++++ PD FVS + D S K+WD+ C +F H + V + NG +
Sbjct: 185 GDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATG 244
Query: 293 GDDQEIHIYD 302
DD ++D
Sbjct: 245 SDDATCRLFD 254
Score = 77.4 bits (189), Expect = 1e-14
Identities = 55/230 (23%), Positives = 100/230 (43%), Gaps = 5/230 (2%)
Query: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
V G LD++ ++ K R+ + + L GH + I SS D LWD
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWD 170
Query: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
+E +Q + D +L+ SPD + +G ++ + G S I
Sbjct: 171 IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230
Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
++++ P+G A+G+ D +FD+ + LL++ + I S+ FS +LL+ D
Sbjct: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYD 290
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
D ++D + AG L+GH + V + D + S D +++W+
Sbjct: 291 DFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 75.5 bits (184), Expect = 6e-14
Identities = 57/273 (20%), Positives = 127/273 (46%), Gaps = 13/273 (4%)
Query: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
+T ++D + ++ ++ + +L GH + ++ + + S+S D + +WD
Sbjct: 33 ITSNMDSVGRI------QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYT 86
Query: 96 GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-IL 152
++ +I T A++P Y+A G +I+ +++ G S + G L
Sbjct: 87 TNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYL 146
Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDG 212
S D + + + D ++DI T + T GH+ + SL+ SPD + V+ + D
Sbjct: 147 SCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDA 206
Query: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD 272
K++D++ + +GH S + V+F P+ F + S D + +++D+ + +
Sbjct: 207 SSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYS 265
Query: 273 HQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
H + + G V ++ +G +++ DD +++D
Sbjct: 266 HDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 100 bits (249), Expect = 2e-21
Identities = 52/197 (26%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
+ + + DS+ L + + GK+ I+ + K +++ R ++++ AY+P G ++A G +D
Sbjct: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118
Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
I +I+ + T ++ L GH + F D+Q+ +T+S D ++D++
Sbjct: 119 NICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQI-ITSSGDTTCALWDIETGQQT 177
Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
+GH+ V++++ PD FVS + D S+K+WDV C TF H+ + V + N
Sbjct: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
Query: 286 GSKIVSVGDDQEIHIYD 302
G + DD ++D
Sbjct: 238 GYAFTTGSDDATCRLFD 254
Score = 77.4 bits (189), Expect = 1e-14
Identities = 62/279 (22%), Positives = 130/279 (46%), Gaps = 13/279 (4%)
Query: 30 ENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
+++ T +T LD + ++ ++ + +L GH + ++ + S+S D +
Sbjct: 27 DSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80
Query: 90 LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTR 147
+WD ++ +I T A++P ++A G +I+ +++ G S +
Sbjct: 81 IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELP 140
Query: 148 GKF-ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
G LS D + + + D ++DI TG+ GH+ + SL+ +PD + V
Sbjct: 141 GHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200
Query: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC 266
+ + D IK++DV+ + T GH S + VAF P+ F + S D + +++D+
Sbjct: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260
Query: 267 VHTFFDHQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
+ + H + + G V ++ +G +++ DD +I+D
Sbjct: 261 L-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
Score = 76.3 bits (186), Expect = 3e-14
Identities = 55/230 (23%), Positives = 99/230 (43%), Gaps = 5/230 (2%)
Query: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
V G LD++ ++ K R+ + + L GH + I SS D LWD
Sbjct: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWD 170
Query: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
+E G+Q D +L+ +PD + +G + ++ V + I
Sbjct: 171 IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDIN 230
Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
++A+ P+G +G+ D +FD+ + L+++ + I S+ FS +LL+ D
Sbjct: 231 AVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYD 290
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
D I+D + AG L+GH + V + D + S D +K+W+
Sbjct: 291 DFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 99.8 bits (247), Expect = 3e-21
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 8/246 (3%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H ++ + WG + + S D +KVW+ D L GH + +++ +
Sbjct: 245 HTQSVTCLRWG-----GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
L A +A + DL+ Q + + + L + L +G+ + ++
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQ--ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWS 357
Query: 135 VESGKKEYSLDTRGKFILS-IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
KK + T + +++ + +SPD + +AS + D I ++D TGK L +L GH +
Sbjct: 358 PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAV 417
Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD 253
+ +S DS+LLV+ S D +K++DV+ LA L GHA V V + PD S D
Sbjct: 418 YQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
Query: 254 KSVKVW 259
K +++W
Sbjct: 478 KCLRIW 483
Score = 92.0 bits (227), Expect = 6e-19
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 7/165 (4%)
Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
SL+ + ++S+A+SP GKYLASG+ D + +D++T T +GH + S+++SPD
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 203 QLLVTASDDGYIKIYDVQHANLAG-TLSGHASWVLNVAF-----CPDDTHFVSSSSDKSV 256
+ L + +G I ++D G TL+GH+ W+ +++ P+ + SSS D SV
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
++WD C H V +++ G+G + S D+ I ++
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272
Score = 89.7 bits (221), Expect = 3e-18
Identities = 60/191 (31%), Positives = 94/191 (49%), Gaps = 7/191 (3%)
Query: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
SLEGH V+SV S T AS S D +R WDL + ++++SPD
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 119 QYLATGTHVGKVNIFGVESGKK-EYSLDTRGKFILSIAY-----SPDGKYLASGAIDGII 172
+ LA+G G++ ++ +GK+ +L K+I +++ +P+ +Y+AS + DG +
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
I+D G+ L GH + L + D LL +AS D IK++ L TL GH
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Query: 233 SWVLNVAFCPD 243
WV +A D
Sbjct: 288 HWVNTMALSTD 298
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/271 (27%), Positives = 124/271 (45%), Gaps = 10/271 (3%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
V + S D V++W R + L GH V + + S+S D I++W
Sbjct: 219 VASSSKDGSVRIWDTTAGRCER--ILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAH 275
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV---GKVNIFGVESGKKEYSLDTRGKFI 151
+G +++ T+A S D L TG VN ++ +E ++
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYA-LRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSPDSQLLVTASD 210
L P+ L SG+ D + ++ A K L + GH I + FSPDS+++ +AS
Sbjct: 335 LVRGQGPER--LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
D IK++D + +L GH + V +A+ D VS SSD ++KVWDV +
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
H D+V+ V ++ +G ++ S G D+ + I+
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 84.7 bits (208), Expect = 9e-17
Identities = 80/340 (23%), Positives = 137/340 (40%), Gaps = 58/340 (17%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
+ H +A+ SVA+ K + +GS D V+ W E ++ +GH+ V+S+
Sbjct: 111 EGHSEAVISVAFSPTGKY----LASGSGDTTVRFWDLSTETP--HFTCKGHRHWVLSISW 164
Query: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS-------PDSQYLATGT 125
S AS + I LWD GKQ+ AG W S P+ +Y+A+ +
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGH-SKWITGLSWEPLHANPECRYVASSS 223
Query: 126 HVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185
G V I+ +G+ E L + + + + DG L S + D I ++ G L T
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRT 282
Query: 186 LEGHAMPIRSLTFSPDSQL----------------------------------------- 204
L+GH + ++ S D L
Sbjct: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE 342
Query: 205 -LVTASDDGYIKIYD-VQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262
LV+ SDD + ++ + ++GH + + V F PD S+S DKS+K+WD
Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402
Query: 263 TRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
T + + H V+ + ++ + +VS D + ++D
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Score = 58.2 bits (139), Expect = 9e-09
Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 6/131 (4%)
Query: 178 ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLN 237
A + +LEGH+ + S+ FSP + L + S D ++ +D+ T GH WVL+
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 238 VAFCPDDTHFVSSSSDKSVKVWDVGTRTCV-HTFFDHQDQVWGVKY-----NGNGSKIVS 291
+++ PD S + + +WD T V T H + G+ + N + S
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 292 VGDDQEIHIYD 302
D + I+D
Sbjct: 222 SSKDGSVRIWD 232
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 99.0 bits (245), Expect = 5e-21
Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+V+GS D+ +KVW + +L GH GV S + + I S S D +++W+ E
Sbjct: 276 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 331
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G+ I ++ + + + +G+ + ++ +E+G+ + L + +
Sbjct: 332 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389
Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
Y DG+ + SGA D ++ ++D T LHTL+GH + SL F D +V+ S D I
Sbjct: 390 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 445
Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
+++DV+ N TL+GH S + D VS ++D +VK+WD+ T C+ T
Sbjct: 446 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
HQ V +++N N +++ DD + ++D
Sbjct: 504 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Score = 95.1 bits (235), Expect = 7e-20
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)
Query: 50 RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
R R+D W L+GH V++ + S S D +++W GK ++
Sbjct: 239 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 297
Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
++ W+ + + +G+ + ++ E+G+ ++L + +
Sbjct: 298 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 353
Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
K + SG+ D + ++DI TG+ LH L GH +R + + D + +V+ + D +K++D +
Sbjct: 354 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 411
Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
TL GH + V ++ F D H VS S D S++VWDV T C+HT HQ G+
Sbjct: 412 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 469
Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
+ N +VS D + I+D
Sbjct: 470 ELKDN--ILVSGNADSTVKIWD 489
Score = 50.8 bits (120), Expect = 1e-06
Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
VV+G+ D +VKVW E +L+GH V S+ + S SLD IR+WD+E
Sbjct: 396 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 451
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G I ++ + T L +G V I+ +++G+ +L K ++
Sbjct: 452 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 509
Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
K ++ + + DG + ++D+ TG+ + L
Sbjct: 510 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 35.4 bits (80), Expect = 0.063
Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)
Query: 21 SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
S+ G K+N +V+G+ D VK+W + + LQ +L+G HQ V + +
Sbjct: 464 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 519
Query: 78 IAASSSLDAHIRLWDLENGKQIKSI 102
I +S D ++LWDL+ G+ I+++
Sbjct: 520 ITSSD--DGTVKLWDLKTGEFIRNL 542
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 99.0 bits (245), Expect = 5e-21
Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+V+GS D+ +KVW + +L GH GV S + + I S S D +++W+ E
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 449
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G+ I ++ + + + +G+ + ++ +E+G+ + L + +
Sbjct: 450 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
Y DG+ + SGA D ++ ++D T LHTL+GH + SL F D +V+ S D I
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 563
Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
+++DV+ N TL+GH S + D VS ++D +VK+WD+ T C+ T
Sbjct: 564 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
HQ V +++N N +++ DD + ++D
Sbjct: 622 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 650
Score = 95.1 bits (235), Expect = 7e-20
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)
Query: 50 RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
R R+D W L+GH V++ + S S D +++W GK ++
Sbjct: 357 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 415
Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
++ W+ + + +G+ + ++ E+G+ ++L + +
Sbjct: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 471
Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
K + SG+ D + ++DI TG+ LH L GH +R + + D + +V+ + D +K++D +
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529
Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
TL GH + V ++ F D H VS S D S++VWDV T C+HT HQ G+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 587
Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
+ N +VS D + I+D
Sbjct: 588 ELKDN--ILVSGNADSTVKIWD 607
Score = 50.8 bits (120), Expect = 1e-06
Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
VV+G+ D +VKVW E +L+GH V S+ + S SLD IR+WD+E
Sbjct: 514 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 569
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G I ++ + T L +G V I+ +++G+ +L K ++
Sbjct: 570 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 627
Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
K ++ + + DG + ++D+ TG+ + L
Sbjct: 628 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 35.4 bits (80), Expect = 0.063
Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)
Query: 21 SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
S+ G K+N +V+G+ D VK+W + + LQ +L+G HQ V + +
Sbjct: 582 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 637
Query: 78 IAASSSLDAHIRLWDLENGKQIKSI 102
I +S D ++LWDL+ G+ I+++
Sbjct: 638 ITSSD--DGTVKLWDLKTGEFIRNL 660
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 99.0 bits (245), Expect = 5e-21
Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+V+GS D+ +KVW + +L GH GV S + + I S S D +++W+ E
Sbjct: 314 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 369
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G+ I ++ + + + +G+ + ++ +E+G+ + L + +
Sbjct: 370 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
Y DG+ + SGA D ++ ++D T LHTL+GH + SL F D +V+ S D I
Sbjct: 428 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 483
Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
+++DV+ N TL+GH S + D VS ++D +VK+WD+ T C+ T
Sbjct: 484 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
HQ V +++N N +++ DD + ++D
Sbjct: 542 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 570
Score = 95.1 bits (235), Expect = 7e-20
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)
Query: 50 RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
R R+D W L+GH V++ + S S D +++W GK ++
Sbjct: 277 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 335
Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
++ W+ + + +G+ + ++ E+G+ ++L + +
Sbjct: 336 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 391
Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
K + SG+ D + ++DI TG+ LH L GH +R + + D + +V+ + D +K++D +
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 449
Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
TL GH + V ++ F D H VS S D S++VWDV T C+HT HQ G+
Sbjct: 450 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 507
Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
+ N +VS D + I+D
Sbjct: 508 ELKDN--ILVSGNADSTVKIWD 527
Score = 50.8 bits (120), Expect = 1e-06
Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
VV+G+ D +VKVW E +L+GH V S+ + S SLD IR+WD+E
Sbjct: 434 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 489
Query: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
G I ++ + T L +G V I+ +++G+ +L K ++
Sbjct: 490 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 547
Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
K ++ + + DG + ++D+ TG+ + L
Sbjct: 548 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 35.4 bits (80), Expect = 0.063
Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)
Query: 21 SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
S+ G K+N +V+G+ D VK+W + + LQ +L+G HQ V + +
Sbjct: 502 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 557
Query: 78 IAASSSLDAHIRLWDLENGKQIKSI 102
I +S D ++LWDL+ G+ I+++
Sbjct: 558 ITSSD--DGTVKLWDLKTGEFIRNL 580
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 98.2 bits (243), Expect = 8e-21
Identities = 51/152 (33%), Positives = 79/152 (51%)
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
+ + +SP G LASG+ D + I+ H +RS+ F D Q VTASD
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85
Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
D +K++ +LS H +WV F PD VS+S DK+VK+WD +R CVH++
Sbjct: 86 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 145
Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
+H V V ++ +G+ I + G D + ++D
Sbjct: 146 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Score = 94.4 bits (233), Expect = 1e-19
Identities = 63/245 (25%), Positives = 106/245 (43%), Gaps = 6/245 (2%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H DA+ V N + + +GS D V++W + + H V SV
Sbjct: 22 HKDAVTCV----NFSPSGHLLASGSRDKTVRIWVPNVKGESTVF--RAHTATVRSVHFCS 75
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
++S D +++W K + S+ FSPD + + + + V ++
Sbjct: 76 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135
Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
S + +S G F+ + + P G +A+ +D + ++D+ T +LL + H+ +
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
L+F P L+TAS D +KI D+ L TL GH VAF +F S SD+
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 255
Query: 255 SVKVW 259
V VW
Sbjct: 256 QVMVW 260
Score = 92.4 bits (228), Expect = 4e-19
Identities = 57/262 (21%), Positives = 119/262 (45%), Gaps = 2/262 (0%)
Query: 40 LDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQI 99
+D + VW + + +++ GH+ V V+ S + + AS S D +R+W +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58
Query: 100 KSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPD 159
A ++ F D Q T + V ++ K +SL ++ +SPD
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
G+ + S + D + ++D ++ + +H+ H + + F P + A D +K++DV
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG 279
+ L H++ V ++F P + +++SSD ++K+ D+ ++T HQ
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
Query: 280 VKYNGNGSKIVSVGDDQEIHIY 301
V ++ G S G D+++ ++
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVW 260
Score = 87.0 bits (214), Expect = 2e-17
Identities = 56/220 (25%), Positives = 100/220 (45%), Gaps = 2/220 (0%)
Query: 84 LDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGVESGKKEY 142
+D+ + +W ++ + G DA T FSP LA+G+ V I+ +
Sbjct: 1 MDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
+ S+ + DG+ + + D + ++ K L +L H +R FSPD
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262
+L+V+ASDD +K++D + H +V V F P T ++ D +VKVWDV
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 263 TRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
T + + H V G+ ++ +G+ +++ D + I D
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 97.8 bits (242), Expect = 1e-20
Identities = 56/166 (33%), Positives = 92/166 (55%), Gaps = 9/166 (5%)
Query: 114 FSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDTRGKF------ILSIAYSPDGKYLAS 165
FSPD QYL TG+ G + ++ +GK K+ + F +L + +S D + LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 166 GAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
GA DG I ++ I +G+ L E H+ + L+FS DS +++AS D I+I+ ++
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
GH+S+V F D + +S+SSD +VK+W++ T C +TF
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTF 387
Score = 75.5 bits (184), Expect = 6e-14
Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 16/197 (8%)
Query: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL--------AFSPDSQYLATGTHVGKVNI 132
+ S+D I +W+ GK K + D + + FS D++ LATG GK+ +
Sbjct: 231 TGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKV 290
Query: 133 FGVESGKKEYSLD-TRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM 191
+ ++SG+ + K + +++S D + S + D I I + +GK L GH+
Sbjct: 291 WKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSS 350
Query: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA------GTLSGHASWVLNVAFCP-DD 244
+ TF+ D +++AS DG +KI++++ + G+ +G V +V P +
Sbjct: 351 FVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNP 410
Query: 245 THFVSSSSDKSVKVWDV 261
HFV + +V + ++
Sbjct: 411 EHFVVCNRSNTVVIMNM 427
Score = 64.3 bits (155), Expect = 1e-10
Identities = 37/164 (22%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERL--DLQWSLEGHQL----GVVSVDISHTLPIAASSSL 84
+ + +VTGS+D ++VW + ++ DL++ + + + V+ + S + A+ +
Sbjct: 225 DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQ 284
Query: 85 DAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKVNIFGVESGKKEYS 143
D I++W +++G+ ++ + T L+FS DS + + + + I G++SGK
Sbjct: 285 DGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE 344
Query: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187
F+ ++ DG Y+ S + DG + I+++ T + +T +
Sbjct: 345 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 52.0 bits (123), Expect = 7e-07
Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 9/127 (7%)
Query: 184 HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA--------SWV 235
H G + FSPD Q LVT S DG+I++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF-FDHQDQVWGVKYNGNGSKIVSVGD 294
L + F D + + D +KVW + + C+ F H V + ++ + S+I+S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 295 DQEIHIY 301
DQ I I+
Sbjct: 328 DQTIRIH 334
Score = 50.8 bits (120), Expect = 1e-06
Identities = 52/253 (20%), Positives = 94/253 (37%), Gaps = 56/253 (22%)
Query: 16 DDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHT 75
DDA+ + + ++E + TG+ D +KVWK + + L+ H GV + S
Sbjct: 264 DDAVLCMCFS----RDTEMLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSKD 318
Query: 76 LPIAASSSLDAHIRLWDLENGKQIKSIDA-----------------------GPVDAWTL 112
S+S D IR+ L++GK +K G V W +
Sbjct: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Query: 113 AFSPDSQYLAT-----GTHVGKVNIFGVESGKKEYSLDTRGKFILSI------------- 154
+ S + GT + ++ + + + + R ++ +
Sbjct: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSG 438
Query: 155 ----------AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
A SP G+++ D ++ F TGKL TL H + + P L
Sbjct: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNL 498
Query: 205 LVTASDDGYIKIY 217
+ T S+DG +K++
Sbjct: 499 IATYSEDGLLKLW 511
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 93.6 bits (231), Expect = 2e-19
Identities = 49/197 (24%), Positives = 99/197 (50%), Gaps = 5/197 (2%)
Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
+ + ++ DS+ L + + GK+ ++ + K +++ R ++++ AY+P G ++A G +D
Sbjct: 59 YAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118
Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
+ +I+++ + K+ L H + F D+ + VT+S D ++D++
Sbjct: 119 NMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNI-VTSSGDTTCALWDIETGQQK 177
Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
GH +++A PD F+S + D S K+WDV TC TF H+ + + + N
Sbjct: 178 TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPN 237
Query: 286 GSKIVSVGDDQEIHIYD 302
G I + DD ++D
Sbjct: 238 GEAICTGSDDASCRLFD 254
Score = 72.0 bits (175), Expect = 6e-13
Identities = 55/251 (21%), Positives = 108/251 (43%), Gaps = 9/251 (3%)
Query: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
+L GH + ++ + + S+S D + +WD ++ +I T A++P
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 119 QYLATGTHVGKVNIFGVESG----KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
++A G +I+ ++S K L ++ + D + S D +
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCAL 168
Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
+DI TG+ GH SL SPD L ++ + D K++DV+ T +GH S
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNGSKIVS 291
+ + F P+ + S D S +++D+ + F H+ + G V ++ +G + +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFA 287
Query: 292 VGDDQEIHIYD 302
DD +++D
Sbjct: 288 GYDDFNCNVWD 298
Score = 71.6 bits (174), Expect = 8e-13
Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 7/231 (3%)
Query: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
V G LD++ ++ K R+ + + L H G +S +SS D LWD
Sbjct: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHT-GYLSCCRFLDDNNIVTSSGDTTCALWD 170
Query: 93 LENGKQIKSIDAGPV-DAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
+E G+Q K++ G D +LA SPD +G ++ V G + I
Sbjct: 171 IETGQQ-KTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLL--HTLEGHAMPIRSLTFSPDSQLLVTAS 209
+I + P+G+ + +G+ D +FD+ + L + E I S+ FS +LL
Sbjct: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGY 289
Query: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
DD ++D + G LSGH + V + D + S D +K+W+
Sbjct: 290 DDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 4/190 (2%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
+ +VT S D +W E + GH +S+ +S + S + DA +L
Sbjct: 153 DDNNIVTSSGDTTCALWDI--ETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKL 210
Query: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE--YSLDTRG 148
WD+ G ++ D + F P+ + + TG+ +F + + ++ +S ++
Sbjct: 211 WDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESII 270
Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
I S+A+S G+ L +G D N++D + + L GH + L + D + T
Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330
Query: 209 SDDGYIKIYD 218
S D ++KI++
Sbjct: 331 SWDSFLKIWN 340
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 92.8 bits (229), Expect = 3e-19
Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71
+AH+D + A+ T+ + + T S+D VK+W L + Q+ +
Sbjct: 654 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 709
Query: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130
SH L +A SS D ++LWDL N K+ ++ G ++ FSPD + LA+ + G +
Sbjct: 710 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767
Query: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176
++ S + S++ + +F L++ ++S DG + A + I +FD
Sbjct: 768 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 825
Query: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
I T LL + GH I+ FSP + L V A +++++ + GH SWV
Sbjct: 826 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 885
Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260
V F PD + F++SS D+++++W+
Sbjct: 886 HGVMFSPDGSSFLTSSDDQTIRLWE 910
Score = 85.9 bits (211), Expect = 4e-17
Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173
FS D Q +A+ + +F E+G+K + +L A+S D +++A+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231
I++ TG+L+HT + H+ + F+ S LL T S D ++K++D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
+ V + F PDD S S+D ++K+WD
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 76.3 bits (186), Expect = 3e-14
Identities = 63/256 (24%), Positives = 106/256 (41%), Gaps = 54/256 (21%)
Query: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW------------------ 49
+F+ H +W + + ++K T+++ S D ++VW W
Sbjct: 995 IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1050
Query: 50 ---RDERLDLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHI 88
++ RL L WS +G HQ V+S DISH +S+S D
Sbjct: 1051 RLLKNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109
Query: 89 RLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------K 140
++W + + + AFS DS LATG G++ I+ V +G+
Sbjct: 1110 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1169
Query: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
E T G ++ + +SPDGK L S G I +++ TG+ T + ++ + SP
Sbjct: 1170 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1227
Query: 201 DSQLLVTASDDGYIKI 216
D + VT + G + I
Sbjct: 1228 DFKTYVTVDNLGILYI 1243
Score = 69.7 bits (169), Expect = 3e-12
Identities = 62/304 (20%), Positives = 136/304 (44%), Gaps = 23/304 (7%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H DA++ + E+ + + + D ++V+K L+ ++ H+ V+ S
Sbjct: 614 HTDAVYHACFS----EDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFST 667
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL--ATGTHVGKVNI 132
A+ S+D +++W+ G+ + + D F+ S +L ATG+ + +
Sbjct: 668 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL------ 186
+ + + ++ + +SPD K LAS + DG + ++D + ++
Sbjct: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 787
Query: 187 -------EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-SGHASWVLNV 238
E + ++ ++S D ++ A+ + I ++D+ + L G + +GH S +
Sbjct: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYC 846
Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298
F P + V + S V++W+ +R+ V H V GV ++ +GS ++ DDQ I
Sbjct: 847 DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 906
Query: 299 HIYD 302
+++
Sbjct: 907 RLWE 910
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)
Query: 87 HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144
HIR L NG+ QI + V L SP QY+A G G + I + + + S
Sbjct: 942 HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 999
Query: 145 DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
K + I ++ D K L S + D I +++ K + L GH ++ +S+L
Sbjct: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1058
Query: 205 LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264
L + S DG +K++++ N H VL+ D T F S+S+DK+ K+W
Sbjct: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117
Query: 265 TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
+H H V ++ + + + + D+ EI I++
Sbjct: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 92.8 bits (229), Expect = 3e-19
Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)
Query: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71
+AH+D + A+ T+ + + T S+D VK+W L + Q+ +
Sbjct: 643 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 698
Query: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130
SH L +A SS D ++LWDL N K+ ++ G ++ FSPD + LA+ + G +
Sbjct: 699 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756
Query: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176
++ S + S++ + +F L++ ++S DG + A + I +FD
Sbjct: 757 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 814
Query: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
I T LL + GH I+ FSP + L V A +++++ + GH SWV
Sbjct: 815 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 874
Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260
V F PD + F++SS D+++++W+
Sbjct: 875 HGVMFSPDGSSFLTSSDDQTIRLWE 899
Score = 85.9 bits (211), Expect = 4e-17
Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173
FS D Q +A+ + +F E+G+K + +L A+S D +++A+ ++D +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231
I++ TG+L+HT + H+ + F+ S LL T S D ++K++D+ T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
+ V + F PDD S S+D ++K+WD
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 76.3 bits (186), Expect = 3e-14
Identities = 63/256 (24%), Positives = 106/256 (41%), Gaps = 54/256 (21%)
Query: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW------------------ 49
+F+ H +W + + ++K T+++ S D ++VW W
Sbjct: 984 IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1039
Query: 50 ---RDERLDLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHI 88
++ RL L WS +G HQ V+S DISH +S+S D
Sbjct: 1040 RLLKNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
Query: 89 RLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------K 140
++W + + + AFS DS LATG G++ I+ V +G+
Sbjct: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158
Query: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
E T G ++ + +SPDGK L S G I +++ TG+ T + ++ + SP
Sbjct: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1216
Query: 201 DSQLLVTASDDGYIKI 216
D + VT + G + I
Sbjct: 1217 DFKTYVTVDNLGILYI 1232
Score = 69.7 bits (169), Expect = 3e-12
Identities = 62/304 (20%), Positives = 136/304 (44%), Gaps = 23/304 (7%)
Query: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
H DA++ + E+ + + + D ++V+K L+ ++ H+ V+ S
Sbjct: 603 HTDAVYHACFS----EDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFST 656
Query: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL--ATGTHVGKVNI 132
A+ S+D +++W+ G+ + + D F+ S +L ATG+ + +
Sbjct: 657 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL------ 186
+ + + ++ + +SPD K LAS + DG + ++D + ++
Sbjct: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
Query: 187 -------EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-SGHASWVLNV 238
E + ++ ++S D ++ A+ + I ++D+ + L G + +GH S +
Sbjct: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYC 835
Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298
F P + V + S V++W+ +R+ V H V GV ++ +GS ++ DDQ I
Sbjct: 836 DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 895
Query: 299 HIYD 302
+++
Sbjct: 896 RLWE 899
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)
Query: 87 HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144
HIR L NG+ QI + V L SP QY+A G G + I + + + S
Sbjct: 931 HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 988
Query: 145 DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
K + I ++ D K L S + D I +++ K + L GH ++ +S+L
Sbjct: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1047
Query: 205 LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264
L + S DG +K++++ N H VL+ D T F S+S+DK+ K+W
Sbjct: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
Query: 265 TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
+H H V ++ + + + + D+ EI I++
Sbjct: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 92.8 bits (229), Expect = 3e-19
Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+ T SLD ++++ RD L+ H V S + I AS S D LW+ E
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
Query: 95 NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
NG+ + ++ PV FSPDS LA+G G V ++ +S K + +
Sbjct: 85 NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203
+ A+SP+G + +G+ G + ++D + LH+ + H + I FS P S
Sbjct: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
Query: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254
L + D +KI+ V ++ G TLSGH + VL AF D VS S DK
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
SV V+D T +HT H V + N + + D+ ++I+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 71.6 bits (174), Expect = 8e-13
Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)
Query: 80 ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
AS + D + LW+ ++ K + S+ G + A AFSP+ + TG+ G + ++ +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183
+K + L G + P DG+ LAS D + I+ ++ +L
Sbjct: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227
Query: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238
TL GH P+ + FS D Q+LV+ S D + +YD N+ TL+ H +V
Sbjct: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287
Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274
AF P+ + S DK+V +W T C +HQ
Sbjct: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
Score = 59.7 bits (143), Expect = 3e-09
Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
N VTGS + VW D+++ S + H LG+ D S + P++ RL
Sbjct: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205
Query: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Q+K W ++F+ +I G E K + +L
Sbjct: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
+L+ A+S DG+ L SG++D + ++D T +LHTL H + + F+P++ LL T S
Sbjct: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
Query: 211 DGYIKIY 217
D + I+
Sbjct: 302 DKTVNIW 308
Score = 30.8 bits (68), Expect = 1.6
Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238
KL+HTL H + FS LL T S D I++Y ++ L H V
Sbjct: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 239 AFCPDDTHFVSSSSDKSVKVWD 260
F P S S+D + +W+
Sbjct: 61 CFSPSGHILASCSTDGTTVLWN 82
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 92.8 bits (229), Expect = 3e-19
Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)
Query: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
+ T SLD ++++ RD L+ H V S + I AS S D LW+ E
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
Query: 95 NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
NG+ + ++ PV FSPDS LA+G G V ++ +S K + +
Sbjct: 85 NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203
+ A+SP+G + +G+ G + ++D + LH+ + H + I FS P S
Sbjct: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
Query: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254
L + D +KI+ V ++ G TLSGH + VL AF D VS S DK
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
SV V+D T +HT H V + N + + D+ ++I+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 71.6 bits (174), Expect = 8e-13
Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)
Query: 80 ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
AS + D + LW+ ++ K + S+ G + A AFSP+ + TG+ G + ++ +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183
+K + L G + P DG+ LAS D + I+ ++ +L
Sbjct: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227
Query: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238
TL GH P+ + FS D Q+LV+ S D + +YD N+ TL+ H +V
Sbjct: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287
Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274
AF P+ + S DK+V +W T C +HQ
Sbjct: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
Score = 59.7 bits (143), Expect = 3e-09
Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)
Query: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
N VTGS + VW D+++ S + H LG+ D S + P++ RL
Sbjct: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205
Query: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Q+K W ++F+ +I G E K + +L
Sbjct: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241
Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
+L+ A+S DG+ L SG++D + ++D T +LHTL H + + F+P++ LL T S
Sbjct: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
Query: 211 DGYIKIY 217
D + I+
Sbjct: 302 DKTVNIW 308
Score = 30.8 bits (68), Expect = 1.6
Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238
KL+HTL H + FS LL T S D I++Y ++ L H V
Sbjct: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 239 AFCPDDTHFVSSSSDKSVKVWD 260
F P S S+D + +W+
Sbjct: 61 CFSPSGHILASCSTDGTTVLWN 82
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,626,192
Number of Sequences: 37866
Number of extensions: 484328
Number of successful extensions: 4184
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 264
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 1089
Number of HSP's gapped (non-prelim): 1559
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.