Search of human proteins with 50843948

Search of human proteins with 50843948

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
         (786 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]          1587   0.0  
gi|208022687 GTPase regulator associated with the focal adhesion...   860   0.0  
gi|7662208 GTPase regulator associated with the focal adhesion k...   842   0.0  
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s...   732   0.0  
gi|4505507 oligophrenin 1 [Homo sapiens]                              628   e-180
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            135   1e-31
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          135   1e-31
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     130   6e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    130   6e-30
gi|187608516 centaurin, beta 2 [Homo sapiens]                         129   1e-29
gi|188497642 ARHGAP15 [Homo sapiens]                                  127   4e-29
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   119   1e-26
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   119   1e-26
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           116   9e-26
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...   115   2e-25
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...   111   2e-24
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]          111   2e-24
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]      104   3e-22
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          103   6e-22
gi|91208437 GEM interacting protein [Homo sapiens]                    102   1e-21
gi|23510413 sorting nexin 26 [Homo sapiens]                           101   2e-21
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...   101   2e-21
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...   101   2e-21
gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]           100   4e-21
gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]           100   4e-21
gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]            100   4e-21
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]       100   4e-21
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi...   100   5e-21
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi...   100   5e-21
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]            100   5e-21

>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score = 1587 bits (4109), Expect = 0.0
 Identities = 786/786 (100%), Positives = 786/786 (100%)

Query: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
           MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF
Sbjct: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60

Query: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
           AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR
Sbjct: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120

Query: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
           KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE
Sbjct: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180

Query: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
           YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE
Sbjct: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240

Query: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
           GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF
Sbjct: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300

Query: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
           NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER
Sbjct: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360

Query: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420
           KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV
Sbjct: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420

Query: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480
           GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI
Sbjct: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480

Query: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540
           VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP
Sbjct: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540

Query: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS 600
           TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS
Sbjct: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS 600

Query: 601 KRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKN 660
           KRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKN
Sbjct: 601 KRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKN 660

Query: 661 HLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV 720
           HLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV
Sbjct: 661 HLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV 720

Query: 721 ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQ 780
           ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQ
Sbjct: 721 ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQ 780

Query: 781 NYVKLL 786
           NYVKLL
Sbjct: 781 NYVKLL 786


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score =  860 bits (2223), Expect = 0.0
 Identities = 457/790 (57%), Positives = 574/790 (72%), Gaps = 35/790 (4%)

Query: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
           MGL  LEFSDC LDSP FRE +++HEAEL++TNKFIKELIKDGK+LI+A K+LS A+RKF
Sbjct: 1   MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60

Query: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
           A SL +FKF+ IGDA TDDE CI  SL+EF+  L+NLE++R  M  + +E LI PLEKFR
Sbjct: 61  ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120

Query: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
           KEQ+GA KE KKK+DKETEK   +++KHLNLS+KKK+S LQEAD QV+  RQHFYE+SLE
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180

Query: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
           YV K+QE+QERK FEFVEP+L+F QG+FTFYH G+ELAKDF  +K +L I+IQNTRNRFE
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240

Query: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
           GTRSEVE LM K+++NP +HK  S +T EGYLYVQEKR   FG+SWVKHYC Y++ +K+ 
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKR--HFGTSWVKHYCTYQRDSKQI 298

Query: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
            M+PF+ +SGGK G+ E   LK CT+R TDSI++RFCFD+EA DRPGV +TMQA SEE+R
Sbjct: 299 TMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGV-ITMQALSEEDR 357

Query: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420
           + W+EA+ G+E +   +N+    + EG AQLD +GF+IIRKCI AVETRGIN+QGLYR+V
Sbjct: 358 RLWMEAMDGREPV---YNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIV 414

Query: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480
           GV+S+VQ+LLS+LMD KT +E + +  A+WE+KTITSALK YLR LP PLM Y+    FI
Sbjct: 415 GVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFI 474

Query: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540
             AK  + ESRV+ IH LVH+LPEKN++ML +L+ HL NV+N+ KQNLMTVANLGVVFGP
Sbjct: 475 KAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGP 534

Query: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPD---TTFPEPTCLSASPPNAPP 597
           TL+RPQEETVAA+MD+KFQNIV+EILIENHEKIF T PD   T          S  + PP
Sbjct: 535 TLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPP 594

Query: 598 RQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGP 657
             S       +RP+ +++     E  +     +     SSL+S+SS             P
Sbjct: 595 SCS-------ERPLTLFHTVQSTEKQE----QRNSIINSSLESVSSNPNSILNSSSSLQP 643

Query: 658 DKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPL-SPGSSPFPFSP 716
           + N       S  D A   P +  S       P +P+ TS  S   P+ S  SSP P S 
Sbjct: 644 NMN------SSDPDLAVVKPTRPNSL------PPNPSPTSPLSPSWPMFSAPSSPMPTS- 690

Query: 717 PATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRG 776
            +T +D  P S   RKA+A+Y C+AEH SELSF  G +F++V  S+EPGWLEGTLNGK G
Sbjct: 691 -STSSDSSPVSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTG 749

Query: 777 LIPQNYVKLL 786
           LIP+NYV+ L
Sbjct: 750 LIPENYVEFL 759


>gi|7662208 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform a [Homo sapiens]
          Length = 814

 Score =  842 bits (2175), Expect = 0.0
 Identities = 454/827 (54%), Positives = 581/827 (70%), Gaps = 54/827 (6%)

Query: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
           MGL  LEFSDC LDSP FRE +++HEAEL++TNKFIKELIKDGK+LI+A K+LS A+RKF
Sbjct: 1   MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60

Query: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
           A SL +FKF+ IGDA TDDE CI  SL+EF+  L+NLE++R  M  + +E LI PLEKFR
Sbjct: 61  ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120

Query: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
           KEQ+GA KE KKK+DKETEK   +++KHLNLS+KKK+S LQEAD QV+  RQHFYE+SLE
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180

Query: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
           YV K+QE+QERK FEFVEP+L+F QG+FTFYH G+ELAKDF  +K +L I+IQNTRNRFE
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240

Query: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
           GTRSEVE LM K+++NP +HK  S +T EGYLYVQEKR   FG+SWVKHYC Y++ +K+ 
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKR--HFGTSWVKHYCTYQRDSKQI 298

Query: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
            M+PF+ +SGGK G+ E   LK CT+R TDSI++RFCFD+EA DRPGV +TMQA SEE+R
Sbjct: 299 TMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGV-ITMQALSEEDR 357

Query: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420
           + W+EA+ G+E +   +N+    + EG AQLD +GF+IIRKCI AVETRGIN+QGLYR+V
Sbjct: 358 RLWMEAMDGREPV---YNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIV 414

Query: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480
           GV+S+VQ+LLS+LMD KT +E + +  A+WE+KTITSALK YLR LP PLM Y+    FI
Sbjct: 415 GVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFI 474

Query: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540
             AK  + ESRV+ IH LVH+LPEKN++ML +L+ HL NV+N+ KQNLMTVANLGVVFGP
Sbjct: 475 KAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGP 534

Query: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPD---TTFPEPTCLSASPPNAPP 597
           TL+RPQEETVAA+MD+KFQNIV+EILIENHEKIF T PD   T          S  + PP
Sbjct: 535 TLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPP 594

Query: 598 RQSKRQGQRTKRPVAVYNLCLELEDGD-------NPYPSKEDTPTSSLDSLSSPSP-VTT 649
             S       +RP+ +++     E  +       +   S    P S L+S SS  P + +
Sbjct: 595 SCS-------ERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNS 647

Query: 650 AVPG------------PPGPDKNHLLADG-GSFGDWASTIPGQTRSSMVQ---------W 687
           + P             PP P     L+     F   +S +P  + SS            W
Sbjct: 648 SDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVW 707

Query: 688 LNPQSPTTTSSNSAVTPLSPGSSPF-PFSPPA-TVADKPPESIRS------RKARAVYPC 739
            +  +   + + S++  +      F P  P    + D+P E++        RKA+A+Y C
Sbjct: 708 FSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYAC 767

Query: 740 EAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL 786
           +AEH SELSF  G +F++V  S+EPGWLEGTLNGK GLIP+NYV+ L
Sbjct: 768 KAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 814


>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
           sapiens]
          Length = 874

 Score =  732 bits (1890), Expect = 0.0
 Identities = 424/881 (48%), Positives = 542/881 (61%), Gaps = 102/881 (11%)

Query: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
           MGL  LEFSD YLDSP FRER++ HE ELERTNKFIKELIKDG  LI A ++LS+A +KF
Sbjct: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60

Query: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
           + SL+DF+FE IGDA TDDE  I  SL+EF+  L  +EE+R  +  +  + LI PLEKFR
Sbjct: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120

Query: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
           KEQ+GA K+ KKKFDKE+EK YS+++KHLNLSAKKK+SHLQEAD Q+++  Q+FYE SLE
Sbjct: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180

Query: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
           YV K+QE+QE+KKFEFVEP+LSF QG+FTFYH+G+ELA++F  YK +LQ N+QNTRN FE
Sbjct: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240

Query: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
            TR EVE LM +++   +D++  SQ+T EGYLYVQEKRP   G +W+KHYC Y K +K F
Sbjct: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRP--LGFTWIKHYCTYDKGSKTF 298

Query: 301 NMIPFEHRSGGKLG-----DGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAF 355
            M   E +S GK+        E+F LK C +R TDSID+RFCFDIE  +R G+ +T+QAF
Sbjct: 299 TMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGI-ITLQAF 357

Query: 356 SEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQG 415
           SE  RK WLEA+ GKE +      AII + E    L++ GF  +RKCI AVETRGI   G
Sbjct: 358 SEANRKLWLEAMDGKEPIYTL--PAIISKKE-EMYLNEAGFNFVRKCIQAVETRGITILG 414

Query: 416 LYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYEL 475
           LYR+ GV+SKVQ+L++     K+  ++D++    W+ KTITS LK YLR L EPLMTY+L
Sbjct: 415 LYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIEL-WDNKTITSGLKNYLRCLAEPLMTYKL 473

Query: 476 HGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLG 535
           H DFI+  KS     RV A+H LVHKLPEKN+EMLDIL+KHL  VS HS+QNLMTV+NLG
Sbjct: 474 HKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLG 533

Query: 536 VVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF--------------------- 574
           V+FGPTLMR QEETVAA+M++KFQNIVVEILIE++EKIF                     
Sbjct: 534 VIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRR 593

Query: 575 ---------------RTPPDTTFPEPTCLSASPPNAP-------PRQSKRQGQRTK---- 608
                          R  P    P+    S+SP + P          S  Q   TK    
Sbjct: 594 TRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASC 653

Query: 609 ---------------------RPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSP--- 644
                                + + ++    E    ++   +  ++   S+ S++SP   
Sbjct: 654 QPREKSGGIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDV 713

Query: 645 SPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTP 704
           SP    V   P        A   S    ++    ++ S  +Q L       T   S    
Sbjct: 714 SPPIDLVKKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPD 773

Query: 705 LSP----------GSSPFPFSPPATVADKP--------PESIRS-RKARAVYPCEAEHSS 745
           L P           SS     P + VA K         P+ + S R+A+A+Y C+AEHS 
Sbjct: 774 LPPKMCRRLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSH 833

Query: 746 ELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL 786
           ELSF  GAIF +V  S EPGWL+ T  GK GL+P+NYV  L
Sbjct: 834 ELSFPQGAIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score =  628 bits (1619), Expect = e-180
 Identities = 363/821 (44%), Positives = 503/821 (61%), Gaps = 70/821 (8%)

Query: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
           MG  PLEFSDCYLDSP FRER++ +E ELERTNKFIK++IKDG  LI+A ++ S A +KF
Sbjct: 1   MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60

Query: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
           + +L+ F+F+FIGD +TDDE  I  S +EF+  L  +E +R +M  + ++ LIKPLE FR
Sbjct: 61  SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120

Query: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
           KEQ+G  KE KKKF+K+ E+ YSL+D+HL+LS+KKK+S LQEAD+QV++ R +F+E SL+
Sbjct: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180

Query: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
           YV ++QE+QE KKF  VEP+L+F   +F       EL +DF  YK +LQ+++QNTRN F 
Sbjct: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240

Query: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
            TR E+EEL  ++++ P+  K   Q T EGYLY QEK     G SWVK+YC Y K  K  
Sbjct: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEK--WALGISWVKYYCQYEKETKTL 298

Query: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
            M P E + G K G  ++  LK C +R T+SID+RFCFDIE  +RPG ++T+QA SE  R
Sbjct: 299 TMTPMEQKPGAKQGPLDL-TLKYCVRRKTESIDKRFCFDIETNERPG-TITLQALSEANR 356

Query: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420
           + W+EA+ GKE + HS  T      +   +L+++GF  +RKCI+ +ET+GI  +GLYR V
Sbjct: 357 RLWMEAMDGKEPIYHSPIT-----KQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTV 411

Query: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480
           G + +VQ+LL+   D K   +VD  NS DW++KTITS+LK YLR+L EP+MTY LH + +
Sbjct: 412 GSNIQVQKLLNAFFDPKCPGDVDFHNS-DWDIKTITSSLKFYLRNLSEPVMTYRLHKELV 470

Query: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540
             AKS + + R+ AIH LV+KLPEKN+EML++L++HL NV  HSK+NLMT +N+GV+FGP
Sbjct: 471 SAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGP 530

Query: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS 600
           TLMR QE+TVAA+M++KFQNIVVEILIE+  KI+  PP+         SA+PP  PPR +
Sbjct: 531 TLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEE--------SAAPPVPPPRVT 582

Query: 601 KRQ------GQRTKRPVAV-YNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAV-- 651
            R+       +R  R   V Y   L+  + +  + +   T TSS++    P      +  
Sbjct: 583 ARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQR 642

Query: 652 -----PGPPGPDKNHL------------------LADGG-------SFGDWASTIPGQTR 681
                PG   P +  L                  L DGG       + G    + P +T 
Sbjct: 643 SGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTP 702

Query: 682 SSMVQWLNPQ-----SPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAV 736
           S  ++   P+           S S V P  PG  P    PP    D P  +   +K    
Sbjct: 703 SFHIKRPAPRPLAHHKEGDADSFSKVRP--PGEKPTIIRPPVRPPDPPCRAATPQKPEPK 760

Query: 737 YPCEAEHSSELSFEIGA----IFEDVQTSREPGWLEGTLNG 773
               A ++ E++  + A     FE    SR+ G  +G L G
Sbjct: 761 PDIVAGNAGEITSSVVASRTRFFE--TASRKTGSSQGRLPG 799


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  135 bits (340), Expect = 1e-31
 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 3/178 (1%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           ++  CI  +E+RG+N +GLYRV G S  ++ +  M  D +   + D+  +   ++  IT 
Sbjct: 284 VVDMCIREIESRGLNSEGLYRVSGFSDLIEDV-KMAFD-RDGEKADISVNMYEDINIITG 341

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
           ALK Y R LP PL+TY+ +  FI  AK   P+ ++  +H  +  LP  + E L  L+ HL
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401

Query: 518 TNVSNHSKQNLMTVANLGVVFGPTLMR-PQEETVAALMDLKFQNIVVEILIENHEKIF 574
             V+ H K+NLM   NLG+VFGPTLMR P+ + +AAL D+++Q +VVE+LI+N + +F
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  135 bits (340), Expect = 1e-31
 Identities = 72/178 (40%), Positives = 111/178 (62%), Gaps = 3/178 (1%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           ++  CI  +E+RG+N +GLYRV G S  ++ +  M  D +   + D+  +   ++  IT 
Sbjct: 258 VVDMCIREIESRGLNSEGLYRVSGFSDLIEDV-KMAFD-RDGEKADISVNMYEDINIITG 315

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
           ALK Y R LP PL+TY+ +  FI  AK   P+ ++  +H  +  LP  + E L  L+ HL
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375

Query: 518 TNVSNHSKQNLMTVANLGVVFGPTLMR-PQEETVAALMDLKFQNIVVEILIENHEKIF 574
             V+ H K+NLM   NLG+VFGPTLMR P+ + +AAL D+++Q +VVE+LI+N + +F
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  130 bits (326), Expect = 6e-30
 Identities = 68/178 (38%), Positives = 108/178 (60%), Gaps = 3/178 (1%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           ++  CI  +E RG+  +GLYRV G +  ++ +  M  D +   + D+  +   ++  IT 
Sbjct: 293 VVDICIREIEARGLKSEGLYRVSGFTEHIEDV-KMAFD-RDGEKADISANVYPDINIITG 350

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
           ALK Y R LP P++TY+ +  FI  AK  + + R+ A+H ++  LP  + E L  L+ HL
Sbjct: 351 ALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHL 410

Query: 518 TNVSNHSKQNLMTVANLGVVFGPTLMRPQEE-TVAALMDLKFQNIVVEILIENHEKIF 574
             V+ + K N M   NLG+VFGPTLMRP E+ T+  L D+++Q ++V+ILIEN + +F
Sbjct: 411 KKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  130 bits (326), Expect = 6e-30
 Identities = 68/178 (38%), Positives = 108/178 (60%), Gaps = 3/178 (1%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           ++  CI  +E RG+  +GLYRV G +  ++ +  M  D +   + D+  +   ++  IT 
Sbjct: 157 VVDICIREIEARGLKSEGLYRVSGFTEHIEDV-KMAFD-RDGEKADISANVYPDINIITG 214

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
           ALK Y R LP P++TY+ +  FI  AK  + + R+ A+H ++  LP  + E L  L+ HL
Sbjct: 215 ALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHL 274

Query: 518 TNVSNHSKQNLMTVANLGVVFGPTLMRPQEE-TVAALMDLKFQNIVVEILIENHEKIF 574
             V+ + K N M   NLG+VFGPTLMRP E+ T+  L D+++Q ++V+ILIEN + +F
Sbjct: 275 KKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 332


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score =  129 bits (324), Expect = 1e-29
 Identities = 102/404 (25%), Positives = 190/404 (47%), Gaps = 48/404 (11%)

Query: 6   LEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLR 65
           ++F +C  DSP FR  +   E ++      + +L+K    +I   K+  VA ++F + +R
Sbjct: 5   VDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIR 64

Query: 66  DFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLG 125
           D       DAV      ++ SL +FS+ L+ +     I+      ++   L+ F KE L 
Sbjct: 65  DLAQYSSNDAV------VETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR 118

Query: 126 AVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKL 185
             K+ KK+F+K +E+  + + K+  +  + K   ++EA   +   R+ F  ++L+YV ++
Sbjct: 119 KFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVLQI 177

Query: 186 QEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSE 245
             +Q +++ E ++ MLSF      F+HQG++L  +   Y  +L   +          + E
Sbjct: 178 NVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKRE 237

Query: 246 VEELMNKIRQ---NPKDHK------RASQFTAEGYLYVQEKRPAPFGSSWVKHY------ 290
           +E+  + I+Q   +  D K       A+    EGYL+   KR +    +W + +      
Sbjct: 238 MEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLF---KRASNAFKTWNRRWFSIQNN 294

Query: 291 -CMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVS 349
             +Y+K  K    +  E              L+ CT +H + I+RRFCF++ +   P  S
Sbjct: 295 QLVYQKKFKDNPTVVVED-------------LRLCTVKHCEDIERRFCFEVVS---PTKS 338

Query: 350 LTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDK 393
             +QA SE+ R+ W+      +A+  S  TA   + + + +LDK
Sbjct: 339 CMLQADSEKLRQAWI------KAVQTSIATAYREKGDESEKLDK 376


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  127 bits (319), Expect = 4e-29
 Identities = 63/181 (34%), Positives = 106/181 (58%), Gaps = 3/181 (1%)

Query: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
           +++CI AVE RG++  G+YRV G  + +Q+L  ++   +  N   L++S   ++  +T A
Sbjct: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLN---LDDSQWEDIHVVTGA 354

Query: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
           LK + R LPEPL  Y     F+   K     +R+ A+  LV KLP  N++ + +L  HLT
Sbjct: 355 LKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLT 414

Query: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
            +   + +NLM+  +LG+VFGPTL+R + ET    + + +QN + E+++  + KIF +  
Sbjct: 415 KIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEE 474

Query: 579 D 579
           D
Sbjct: 475 D 475


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  119 bits (297), Expect = 1e-26
 Identities = 68/180 (37%), Positives = 100/180 (55%), Gaps = 5/180 (2%)

Query: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
           +++CI AVE RG++  GLYR+ G  + +Q+L      V     +DL++    +V  IT A
Sbjct: 346 VQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITGA 402

Query: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
           LK + R LPEPL  +     FI   K      R   +  LV  LP  N + L +L +HL 
Sbjct: 403 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 462

Query: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
            V  H +QN M+V ++ +VFGPTL+RP+ E  +  M + FQN VVE++++    IF  PP
Sbjct: 463 RVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF--PP 520


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  119 bits (297), Expect = 1e-26
 Identities = 68/180 (37%), Positives = 100/180 (55%), Gaps = 5/180 (2%)

Query: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
           +++CI AVE RG++  GLYR+ G  + +Q+L      V     +DL++    +V  IT A
Sbjct: 373 VQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITGA 429

Query: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
           LK + R LPEPL  +     FI   K      R   +  LV  LP  N + L +L +HL 
Sbjct: 430 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 489

Query: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
            V  H +QN M+V ++ +VFGPTL+RP+ E  +  M + FQN VVE++++    IF  PP
Sbjct: 490 RVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF--PP 547


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  116 bits (290), Expect = 9e-26
 Identities = 62/176 (35%), Positives = 102/176 (57%), Gaps = 4/176 (2%)

Query: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
           ++ CI  VE  G++  G+YRV G  + +Q+L      V    ++DL +S   ++  IT A
Sbjct: 673 VKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLR---FAVNHDEKLDLNDSKWEDIHVITGA 729

Query: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
           LK + R LPEPL T+    DF+   K   P  RV A+  L+ +LP+ N++ + IL +HL 
Sbjct: 730 LKMFFRELPEPLFTFNHFNDFVNAIKQ-EPRQRVAAVKDLIRQLPKPNQDTMQILFRHLR 788

Query: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF 574
            V  + ++N MT  ++ +VFGPTL++P++ET    +   +QN +VE+++     IF
Sbjct: 789 RVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score =  115 bits (288), Expect = 2e-25
 Identities = 114/443 (25%), Positives = 192/443 (43%), Gaps = 49/443 (11%)

Query: 6   LEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLR 65
           +EF +C  DSP FR  I   E ++      + +L+K    ++ A K+     R F   +R
Sbjct: 3   VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62

Query: 66  DFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLG 125
           D   +  GD V      I   L+ F++ L+ +     I+      ++ + L+ F KE + 
Sbjct: 63  DLSQQCQGDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVR 116

Query: 126 AVKEEKKKFDKETEK-NYSLIDKHLNLSAKKKDSH-LQEADIQVEQNRQHFYELSLEYVC 183
             KE KK+FDK  E    SL+    N  A +   H ++EA   +   R+ F  L+L+YV 
Sbjct: 117 KFKETKKQFDKVREDLELSLVR---NAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVL 173

Query: 184 KLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTR 243
           ++  +Q +KKFE ++ MLSF     +F+ QG+ L    + Y  +L   +          +
Sbjct: 174 QINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEK 233

Query: 244 SEVEELMNKIRQNPK-------------DHKRASQFTAEGYLYVQEKRPAPFGSSWVKHY 290
            E+E     I+Q                D    S    EGYL+   KR +    +W + +
Sbjct: 234 REMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLF---KRASNAFKTWNRRW 290

Query: 291 CMYRKAAKKFNMIPFEHRSGGKLGDG---EVFFLKECTKRHTDSIDRRFCFDIEAADRPG 347
              + +   +           KL D     V  L+ C+ +  + I+RRFCF++ +   P 
Sbjct: 291 FSIQNSQLVYQK---------KLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLS---PT 338

Query: 348 VSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVE 407
            S  +QA SE+ R+ W++A+    A ++  +    P    + +LD+          SA +
Sbjct: 339 KSCMLQADSEKLRQAWVQAVQASIASAYRES----PDSCYSERLDRTASPSTSSIDSATD 394

Query: 408 TRGINDQG---LYRVVGVSSKVQ 427
           TR    +G   L RV  V+   Q
Sbjct: 395 TRERGVKGESVLQRVQSVAGNSQ 417


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score =  111 bits (278), Expect = 2e-24
 Identities = 65/218 (29%), Positives = 107/218 (49%), Gaps = 23/218 (10%)

Query: 399  IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
            I +CI  +E  G++ +G+YRV G  S+++   S+       + +DL    D+ V T+  A
Sbjct: 1265 IERCIEYIEATGLSTEGIYRVSGNKSEME---SLQRQFDQDHNLDLAEK-DFTVNTVAGA 1320

Query: 459  LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
            +K +   LP+PL+ Y +  D +   K    E +++A+  ++ K P++N E+   ++ HL 
Sbjct: 1321 MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN 1380

Query: 519  NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
             VS+++K NLMT  NL + F PTLMRP   T+ AL   +    ++E+ I+     F   P
Sbjct: 1381 KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRP 1440

Query: 579  DTTFP-------------------EPTCLSASPPNAPP 597
             T  P                    P     SPP +PP
Sbjct: 1441 ITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPP 1478



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 5/51 (9%)

Query: 120  RKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQN 170
            R+++L A+KE  KKF KE  + +  +  HLN     K SH  + ++   +N
Sbjct: 1350 REQKLHALKEVLKKFPKENHEVFKYVISHLN-----KVSHNNKVNLMTSEN 1395


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score =  111 bits (278), Expect = 2e-24
 Identities = 68/203 (33%), Positives = 109/203 (53%), Gaps = 8/203 (3%)

Query: 398  IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
            I+  C   VE RG+   G+YRV G ++ +  +   L   K   ++D+++    ++  I+S
Sbjct: 1164 IVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN--KGMADIDIQDDKWRDLNVISS 1221

Query: 458  ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
             LK + R LPEPL T + + DFI   +   P  R+  +  L+H LPE + E L  L  HL
Sbjct: 1222 LLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHL 1281

Query: 518  TNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALM-DLKFQNIVVEILIENHEKIF-- 574
              V+ +S++N M   NL +VFGPTL+R  E+ +  ++  +  Q  +VE LI++H+  F  
Sbjct: 1282 KTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTE 1341

Query: 575  --RTPPDTTFPEPTCLSASP-PN 594
                 P TT  E + + + P PN
Sbjct: 1342 EGAEEPLTTVQEESTVDSQPVPN 1364


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score =  104 bits (260), Expect = 3e-22
 Identities = 68/210 (32%), Positives = 109/210 (51%), Gaps = 31/210 (14%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           I++KC+  +E R +  +G+YRV GV ++V++L     + K   E+   +  D     I++
Sbjct: 777 IVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD-----ISN 831

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSG----------------SPESRVNAIHF---- 497
            LK YLR LPEPL+++ L+ + +  AK                    ES   A+      
Sbjct: 832 VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891

Query: 498 --LVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQ--EETV--A 551
             L+  LP +N+  L  L++HL  +    + N MT  NLG+VFGPTL+RP+  E TV  +
Sbjct: 892 RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951

Query: 552 ALMDLKFQNIVVEILIENHEKIFRTPPDTT 581
           +L+D   Q  V+E LI ++  +F   P+ T
Sbjct: 952 SLVDYPHQARVIETLIVHYGLVFEEEPEET 981


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  103 bits (257), Expect = 6e-22
 Identities = 98/349 (28%), Positives = 149/349 (42%), Gaps = 41/349 (11%)

Query: 398  IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
            I+  C   VE RG+   G+YRV G ++ V  L   L   +   +++L++    ++  I+S
Sbjct: 828  IVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLN--RGPGDINLQDERWQDLNVISS 885

Query: 458  ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
             LK + R LPEPL T + + DFI   +      R+  +  L+  LP    E L  LV HL
Sbjct: 886  LLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHL 945

Query: 518  TNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALM-DLKFQNIVVEILIENHEKIFRT 576
              +++HS++N M   NL +VFGPTL+R  E+ +  ++  +  +  +VE LI++ +  F  
Sbjct: 946  KTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSD 1005

Query: 577  PPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTS 636
              D    E T +    P A P               + N+   +  GD   P  + T  S
Sbjct: 1006 EEDK--GERTPVGDKEPQAVPNIE----------YLLPNIGRTVPPGD---PGSDSTTCS 1050

Query: 637  SLDSLSSPSP----------VTTAVPGPPGPDKNHLLADG-GSFGDWAST----IPGQTR 681
            S  S  S +P            + +       K    A G GS  D  S      PG   
Sbjct: 1051 SAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGA 1110

Query: 682  SSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRS 730
            ++      PQ P       AV P +PG      SPPA   ++P    RS
Sbjct: 1111 TAPGTQERPQGPLP----GAVAPEAPGR----LSPPAAPEERPAADTRS 1151


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score =  102 bits (255), Expect = 1e-21
 Identities = 74/229 (32%), Positives = 115/229 (50%), Gaps = 35/229 (15%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
           ++ KC + +E R ++ QG+YRV G   +V+RL     + +   E+   +  D     ++S
Sbjct: 567 VVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHD-----VSS 621

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAK-------------SGSPESRVNAIHFLVHKLPE 504
            LK++L+ L EP++ + L+  FI  AK             S SPE  + ++  L+ +LP+
Sbjct: 622 VLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEV-IRSLKTLLVQLPD 680

Query: 505 KNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAA-------LMDLK 557
            N   L  LV HL  V+    +N M+  NLG+VFGPTL+RP +   AA       L+D  
Sbjct: 681 SNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSG 740

Query: 558 FQNIVVEILIENHEKIF---------RTPPDTTFPEPTCLSASPPNAPP 597
            Q  +VE LI ++E+IF           PP  + P P  L+ S    PP
Sbjct: 741 HQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPP 789


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score =  101 bits (252), Expect = 2e-21
 Identities = 107/406 (26%), Positives = 169/406 (41%), Gaps = 59/406 (14%)

Query: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADW------- 450
           ++R C   +E  G+ D G+YR+ GVSS +QRL          +E D E   +        
Sbjct: 331 VLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLR---------HEFDSERIPELSGPAFLQ 380

Query: 451 EVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEML 510
           ++ +++S  K Y R LP PL+TY+L+G F         E R+  +H ++ +LP  +   L
Sbjct: 381 DIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTL 440

Query: 511 DILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQE-ETV-----AALMDLKFQNIVVE 564
           + L++HL  ++ HS    M   NL +V+ P L+R  E E+V     AA  +++ Q++VVE
Sbjct: 441 EYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVE 500

Query: 565 ILIENHEKIFRTPPDTT---------FPEPTCLSASPPN--------APPRQSKRQGQRT 607
            L+ + + +F     +           P P  L+ S P+        A  R   R G  T
Sbjct: 501 FLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPT 560

Query: 608 KRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGG 667
           + P          E        K+  P       SS         GP  P K  L   GG
Sbjct: 561 E-PTTPKAPASPAERRKGERGEKQRKPGG-----SSWKTFFALGRGPSVPRKKPLPWLGG 614

Query: 668 SFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKP--- 724
           +    A   P  +R   V   + +S  + SS ++   L  G+   P S   T A  P   
Sbjct: 615 T---RAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELL-GAGGAPASATPTPALSPGRS 670

Query: 725 ------PESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREP 764
                 P  +R  +A     C+ E  S+L    G +  D+++   P
Sbjct: 671 LRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPP 716


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score =  101 bits (252), Expect = 2e-21
 Identities = 62/194 (31%), Positives = 102/194 (52%), Gaps = 17/194 (8%)

Query: 397 TIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTC----------------N 440
           + +R CI+AV+ RG++  G+YRV G  + VQ+L   L+D +                   
Sbjct: 538 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKL-RFLVDRERAVTSDGRYVFPEQPGQEG 596

Query: 441 EVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVH 500
            +DL+++   ++  +T ALK +LR LP+PL+   L   F         E  ++ I  L+ 
Sbjct: 597 RLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIG 656

Query: 501 KLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQN 560
            +P+ N + L  L++HL  V  HS +N MT  NLG+VFGPTL RP++ET        +  
Sbjct: 657 SMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPG 716

Query: 561 IVVEILIENHEKIF 574
            +V++++ N   +F
Sbjct: 717 QLVQLMLTNFTSLF 730


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score =  101 bits (252), Expect = 2e-21
 Identities = 62/194 (31%), Positives = 102/194 (52%), Gaps = 17/194 (8%)

Query: 397 TIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTC----------------N 440
           + +R CI+AV+ RG++  G+YRV G  + VQ+L   L+D +                   
Sbjct: 354 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKL-RFLVDRERAVTSDGRYVFPEQPGQEG 412

Query: 441 EVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVH 500
            +DL+++   ++  +T ALK +LR LP+PL+   L   F         E  ++ I  L+ 
Sbjct: 413 RLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIG 472

Query: 501 KLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQN 560
            +P+ N + L  L++HL  V  HS +N MT  NLG+VFGPTL RP++ET        +  
Sbjct: 473 SMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPG 532

Query: 561 IVVEILIENHEKIF 574
            +V++++ N   +F
Sbjct: 533 QLVQLMLTNFTSLF 546


>gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  100 bits (250), Expect = 4e-21
 Identities = 65/182 (35%), Positives = 102/182 (56%), Gaps = 8/182 (4%)

Query: 389 AQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSA 448
           +Q   M  +I+  C++ +E RG+ + GLYR+ G    V+ L    + VKT   V L +  
Sbjct: 356 SQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT---VPLLSKV 412

Query: 449 DWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKE 508
           D ++  I S LK +LR+L EPL+T+ L+  F+  A+    ++ + A++  V +LP+ N++
Sbjct: 413 D-DIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRD 471

Query: 509 MLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMR---PQEETVAALMDLKFQNIVVEI 565
            L  L+ HL  V+  S    M VANL  VFGPT++    P  + V  L D+K Q  VVE 
Sbjct: 472 TLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVER 530

Query: 566 LI 567
           L+
Sbjct: 531 LL 532


>gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  100 bits (250), Expect = 4e-21
 Identities = 65/182 (35%), Positives = 102/182 (56%), Gaps = 8/182 (4%)

Query: 389 AQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSA 448
           +Q   M  +I+  C++ +E RG+ + GLYR+ G    V+ L    + VKT   V L +  
Sbjct: 356 SQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT---VPLLSKV 412

Query: 449 DWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKE 508
           D ++  I S LK +LR+L EPL+T+ L+  F+  A+    ++ + A++  V +LP+ N++
Sbjct: 413 D-DIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRD 471

Query: 509 MLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMR---PQEETVAALMDLKFQNIVVEI 565
            L  L+ HL  V+  S    M VANL  VFGPT++    P  + V  L D+K Q  VVE 
Sbjct: 472 TLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVER 530

Query: 566 LI 567
           L+
Sbjct: 531 LL 532


>gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score =  100 bits (250), Expect = 4e-21
 Identities = 65/182 (35%), Positives = 102/182 (56%), Gaps = 8/182 (4%)

Query: 389 AQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSA 448
           +Q   M  +I+  C++ +E RG+ + GLYR+ G    V+ L    + VKT   V L +  
Sbjct: 356 SQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT---VPLLSKV 412

Query: 449 DWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKE 508
           D ++  I S LK +LR+L EPL+T+ L+  F+  A+    ++ + A++  V +LP+ N++
Sbjct: 413 D-DIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRD 471

Query: 509 MLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMR---PQEETVAALMDLKFQNIVVEI 565
            L  L+ HL  V+  S    M VANL  VFGPT++    P  + V  L D+K Q  VVE 
Sbjct: 472 TLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVER 530

Query: 566 LI 567
           L+
Sbjct: 531 LL 532


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score =  100 bits (250), Expect = 4e-21
 Identities = 107/406 (26%), Positives = 169/406 (41%), Gaps = 87/406 (21%)

Query: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDL-ENSADWEVKTITS 457
           I  C++ +   G+ ++GL+RV   +SK+++L + L     C  VD+ E SAD     I  
Sbjct: 272 IEACVTMLLECGMQEEGLFRVAPSASKLKKLKAAL----DCCVVDVQEYSAD--PHAIAG 325

Query: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
           ALK YLR LPEPLMT+EL+ ++I  +     + ++ A+     KLP+ N   +  L+K L
Sbjct: 326 ALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFL 385

Query: 518 TNVSNHSKQNLMTVANLGVVFGPTLMRPQEE-TVAALMDLKFQNIV--VEILIENHEKIF 574
           + +S +   N MT +N+ +V GP L+ PQ E  +  +M      IV  +E +I++ +  F
Sbjct: 386 SKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFF 445

Query: 575 RTPPDTTF-------------PEPTCLSASPPNAPPRQSKRQGQRTKRP--VAVYNLCLE 619
             P +  F                   S   P+  P   +RQ ++ +RP  VA  N+ LE
Sbjct: 446 --PGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDP-ADRRQPEQARRPLSVATDNMMLE 502

Query: 620 LEDGDN-------------------------------------PYPSKE-------DTPT 635
               D                                      P P  E         P 
Sbjct: 503 FYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPE 562

Query: 636 SSLDSLSSPSPVTTAVPGPPGPDKNHLLADGG-SFGDWASTIPGQTRSSMVQWLNPQSPT 694
             LDS ++P+   + +   PGP++         S G      PG ++ +      P    
Sbjct: 563 QPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQP---- 618

Query: 695 TTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIR--SRKARAVYP 738
                 A     PG+SP P  PP   AD+ P ++R  S+K   + P
Sbjct: 619 -----GAQPGAQPGASPSPSQPP---ADQSPHTLRKVSKKLAPIPP 656


>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
          Length = 1502

 Score =  100 bits (249), Expect = 5e-21
 Identities = 64/201 (31%), Positives = 93/201 (46%), Gaps = 7/201 (3%)

Query: 399  IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
            + KC+  +E  G+  +GLYRV G  +    +          N V +E +    V  +  A
Sbjct: 1278 VEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVT----VNAVAGA 1333

Query: 459  LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
            LK +   LP+PL+ Y LH + +  AK      R++A+  +V K    N ++   ++ HL 
Sbjct: 1334 LKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLN 1393

Query: 519  NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
             VS   K NLMT  NL + F PTLMRP  E    L   K    VVE  I+  +  F    
Sbjct: 1394 RVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFY--- 1450

Query: 579  DTTFPEPTCLSASPPNAPPRQ 599
            +    E T + A PP + P Q
Sbjct: 1451 NGEIVETTNIVAPPPPSNPGQ 1471


>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
          Length = 1501

 Score =  100 bits (249), Expect = 5e-21
 Identities = 64/201 (31%), Positives = 93/201 (46%), Gaps = 7/201 (3%)

Query: 399  IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
            + KC+  +E  G+  +GLYRV G  +    +          N V +E +    V  +  A
Sbjct: 1277 VEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVT----VNAVAGA 1332

Query: 459  LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
            LK +   LP+PL+ Y LH + +  AK      R++A+  +V K    N ++   ++ HL 
Sbjct: 1333 LKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLN 1392

Query: 519  NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
             VS   K NLMT  NL + F PTLMRP  E    L   K    VVE  I+  +  F    
Sbjct: 1393 RVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFY--- 1449

Query: 579  DTTFPEPTCLSASPPNAPPRQ 599
            +    E T + A PP + P Q
Sbjct: 1450 NGEIVETTNIVAPPPPSNPGQ 1470


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score =  100 bits (249), Expect = 5e-21
 Identities = 107/428 (25%), Positives = 178/428 (41%), Gaps = 39/428 (9%)

Query: 349 SLTMQAFSEEERKQWLEA--------LGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIR 400
           +L + A S+ + + W++A        LGG         T    R  G     ++   ++ 
Sbjct: 122 ALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYG----PRLAPLLVE 177

Query: 401 KCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALK 460
           +C+  +  RG+ ++GL+R+ G ++ V+ L     D   C E  L +S   +V T+ S LK
Sbjct: 178 QCVDFIRERGLTEEGLFRMPGQANLVRDL----QDSFDCGEKPLFDSTT-DVHTVASLLK 232

Query: 461 QYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFL--VHKLPEKNKEMLDILVKHLT 518
            YLR LPEP++ +  + DF+  A+  + +     +     V  LP+ N  +L  + K L 
Sbjct: 233 LYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLD 292

Query: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMD-LKFQNIVVEILIENHEKIFR-- 575
            V  +S  N M+V NL  VFGP ++RPQ E    +M+       ++ +LI  H ++F   
Sbjct: 293 EVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAP 352

Query: 576 TPPDTTFP-------------EPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELED 622
            P   T P             E T  S   P  P   + R        VAV +       
Sbjct: 353 VPEGPTSPRGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLDGAAVAVLSRTAPTGP 412

Query: 623 GDNPYPSKE-DTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSF-GDWASTIPGQT 680
           G    P K+  T  S   S   P  ++ +  G     +  +++ GG++  +  S++ G  
Sbjct: 413 GSRCSPGKKVQTLPSWKSSFRQPRSLSGSPKGGGSSLEVPIISSGGNWLMNGLSSLRGHR 472

Query: 681 RSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCE 740
           R+S    L         S     P +PG  P      A++A     S  S    ++  C 
Sbjct: 473 RASSGDRLKDSGSVQRLSTYDNVP-APGLVP-GIPSVASMAWSGASSSESSVGGSLSSCT 530

Query: 741 AEHSSELS 748
           A  +S+ S
Sbjct: 531 ACRASDSS 538


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,652,806
Number of Sequences: 37866
Number of extensions: 1688864
Number of successful extensions: 11288
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 490
Number of HSP's that attempted gapping in prelim test: 9467
Number of HSP's gapped (non-prelim): 1985
length of query: 786
length of database: 18,247,518
effective HSP length: 110
effective length of query: 676
effective length of database: 14,082,258
effective search space: 9519606408
effective search space used: 9519606408
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.