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Search of human proteins with 4885489
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog
[Homo sapiens]
(346 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog [... 701 0.0
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 119 5e-27
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 119 5e-27
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 115 4e-26
gi|187475373 c-src tyrosine kinase [Homo sapiens] 108 7e-24
gi|4758078 c-src tyrosine kinase [Homo sapiens] 108 7e-24
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 103 3e-22
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 103 3e-22
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 103 3e-22
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 103 3e-22
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 100 2e-21
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 100 2e-21
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 99 6e-21
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 98 1e-20
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 96 6e-20
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 95 8e-20
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 95 8e-20
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 95 1e-19
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 95 1e-19
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 95 1e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 93 3e-19
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 92 7e-19
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 92 7e-19
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 92 9e-19
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 91 1e-18
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 91 2e-18
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 91 2e-18
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 91 2e-18
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 90 3e-18
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 90 3e-18
>gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog
[Homo sapiens]
Length = 346
Score = 701 bits (1809), Expect = 0.0
Identities = 346/346 (100%), Positives = 346/346 (100%)
Query: 1 MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQV 60
MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQV
Sbjct: 1 MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQV 60
Query: 61 CLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRV 120
CLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRV
Sbjct: 61 CLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRV 120
Query: 121 VAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLK 180
VAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLK
Sbjct: 121 VAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLK 180
Query: 181 YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLG 240
YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLG
Sbjct: 181 YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLG 240
Query: 241 GTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLS 300
GTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLS
Sbjct: 241 GTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLS 300
Query: 301 AAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAELG 346
AAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAELG
Sbjct: 301 AAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAELG 346
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 119 bits (297), Expect = 5e-27
Identities = 82/292 (28%), Positives = 141/292 (48%), Gaps = 41/292 (14%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRH 114
+ +E++ LQ +G+G G+V+ + G VA+K+V + + R +L+H
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR---------KLKH 170
Query: 115 DNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLS 174
NI+ T+ P I+MEF L++V+ R G ++
Sbjct: 171 PNIITFKGVCTQAPCYC-----ILMEFCAQGQLYEVL----------------RAGRPVT 209
Query: 175 LGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQT 234
+ +S+ + G+ +LH I+H DLK N+LI+ DV KISDFG S++L D ++
Sbjct: 210 PSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSD----KS 265
Query: 235 PSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSG-ERQHILYAVVAY 293
GT APE+++ E V+ K DI+SF + LW++ T + PY + I++ V +
Sbjct: 266 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGS- 324
Query: 294 DLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAEL 345
SL V G ++ ++++CW RPS R +L+ L A++
Sbjct: 325 ---NSLHLPVPSSCPDGFKI--LLRQCWNSKPRNRPSFRQILLHLDIASADV 371
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 119 bits (297), Expect = 5e-27
Identities = 93/334 (27%), Positives = 164/334 (49%), Gaps = 45/334 (13%)
Query: 22 RPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRG 81
RP +SP+ P++ P P +A+ E++ L + +GAGGFG VY+AT++G
Sbjct: 101 RPAASPAPPPSR----------PSSPVHVAF-----ERLELKELIGAGGFGQVYRATWQG 145
Query: 82 VPVAIKQVNKCTK-NRLASRRSFWAELNV-ARLRHDNIVRVVAASTRTPAGSNSLGTIIM 139
VA+K + + + A+ S E + A LRH NI+ + + P +++
Sbjct: 146 QEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLC-----LVL 200
Query: 140 EFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQS--- 196
EF L++ + A P+ A P R ++ + +++ + G+L+LH ++
Sbjct: 201 EFARGGALNRALAAANAAPDPRAPGP--RRARRIPPHVLVNWAVQIARGMLYLHEEAFVP 258
Query: 197 IVHLDLKPANILISEQ----DVC----KISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAP 248
I+H DLK +NIL+ E+ D+C KI+DFG + + +T GTY AP
Sbjct: 259 ILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH-----RTTKMSTAGTYAWMAP 313
Query: 249 ELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFEDSL 308
E++K + +DI+S+ + LW++ T + PY G I VAY + + +
Sbjct: 314 EVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRG----IDGLAVAYGVAVNKLTLPIPSTC 369
Query: 309 PGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLK 342
P + +++ CW+ RPS L+L LT+++
Sbjct: 370 P-EPFAKLMKECWQQDPHIRPSFALILEQLTAIE 402
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 115 bits (289), Expect = 4e-26
Identities = 85/316 (26%), Positives = 151/316 (47%), Gaps = 42/316 (13%)
Query: 31 PAKLLLGATLPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVN 90
P ++G +L ++ W + +E++ LQ LG+G G+V+ +R VAIK+V
Sbjct: 140 PVWNIIGKAYSTDYKLQQQDTW-EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVR 198
Query: 91 KCTKNRLASRRSFWAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQV 150
+ + + R +L+H NI+ T+ P IIME+ + L++V
Sbjct: 199 EQNETDIKHLR---------KLKHPNIIAFKGVCTQAPCYC-----IIMEYCAHGQLYEV 244
Query: 151 IYGAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILIS 210
+ R G +++ + +S + +G+ +LH I+H DLK N+L++
Sbjct: 245 L----------------RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT 288
Query: 211 EQDVCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLW 270
D KISDFG S++L D ++ GT APE+++ E V+ K DI+SF + LW
Sbjct: 289 HTDAVKISDFGTSKELSD----KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 344
Query: 271 QMTTKQAPYSG-ERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRP 329
++ T + PY + I++ V + SL V G ++ ++++ W+ RP
Sbjct: 345 ELLTGEIPYKDVDSSAIIWGVGS----NSLHLPVPSTCPDGFKI--LMKQTWQSKPRNRP 398
Query: 330 SARLLLVDLTSLKAEL 345
S R L+ L A++
Sbjct: 399 SFRQTLMHLDIASADV 414
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 108 bits (270), Expect = 7e-24
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 46/300 (15%)
Query: 49 RLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN 108
R W +++ +++ LLQ +G G FG V YRG VA+K C KN A+ ++F AE +
Sbjct: 185 RSGW-ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK----CIKND-ATAQAFLAEAS 238
Query: 109 V-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHC 167
V +LRH N+V++ LG I+ E GG +Y + + +
Sbjct: 239 VMTQLRHSNLVQL-------------LGVIVEEKGG-------LYIVTEYMAKGSLVDYL 278
Query: 168 RTGGQLSLGK--CLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
R+ G+ LG LK+SLDV + +L + VH DL N+L+SE +V K+SDFG +++
Sbjct: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQM-TTKQAPYSGERQ 284
T P+ T APE L+ + + K+D++SF I LW++ + + PY
Sbjct: 339 ASSTQ--DTGKLPVKWT----APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP---- 388
Query: 285 HILYAVVAYDLRPSLSAAVFEDSLPG--QRLGDVIQRCWRPSAAQRPSARLLLVDLTSLK 342
+ D+ P + D+ G + +V++ CW AA RPS L L +K
Sbjct: 389 ----RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIK 444
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 108 bits (270), Expect = 7e-24
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 46/300 (15%)
Query: 49 RLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN 108
R W +++ +++ LLQ +G G FG V YRG VA+K C KN A+ ++F AE +
Sbjct: 185 RSGW-ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK----CIKND-ATAQAFLAEAS 238
Query: 109 V-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHC 167
V +LRH N+V++ LG I+ E GG +Y + + +
Sbjct: 239 VMTQLRHSNLVQL-------------LGVIVEEKGG-------LYIVTEYMAKGSLVDYL 278
Query: 168 RTGGQLSLGK--CLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
R+ G+ LG LK+SLDV + +L + VH DL N+L+SE +V K+SDFG +++
Sbjct: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQM-TTKQAPYSGERQ 284
T P+ T APE L+ + + K+D++SF I LW++ + + PY
Sbjct: 339 ASSTQ--DTGKLPVKWT----APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP---- 388
Query: 285 HILYAVVAYDLRPSLSAAVFEDSLPG--QRLGDVIQRCWRPSAAQRPSARLLLVDLTSLK 342
+ D+ P + D+ G + +V++ CW AA RPS L L +K
Sbjct: 389 ----RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIK 444
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 103 bits (256), Expect = 3e-22
Identities = 86/295 (29%), Positives = 148/295 (50%), Gaps = 46/295 (15%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN-VARLR 113
ID++++ + + +G G FG V KA +R VAIKQ+ ++ R++F EL ++R+
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE-----RKAFIVELRQLSRVN 85
Query: 114 HDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQL 173
H NIV++ A ++ME+ +L+ V++GA P A
Sbjct: 86 HPNIVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAH--------- 129
Query: 174 SLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANIL-ISEQDVCKISDFGCSEKLEDL 229
++ CL+ S G+ +LHS ++++H DLKP N+L ++ V KI DFG + +
Sbjct: 130 AMSWCLQCS----QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI--- 182
Query: 230 LCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPY---SGERQHI 286
QT G+ APE+ +G + K D++S+ I LW++ T++ P+ G I
Sbjct: 183 ---QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRI 239
Query: 287 LYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
++A V RP L +LP + + ++ RCW +QRPS ++ +T L
Sbjct: 240 MWA-VHNGTRPPLI-----KNLP-KPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 103 bits (256), Expect = 3e-22
Identities = 86/295 (29%), Positives = 148/295 (50%), Gaps = 46/295 (15%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN-VARLR 113
ID++++ + + +G G FG V KA +R VAIKQ+ ++ R++F EL ++R+
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE-----RKAFIVELRQLSRVN 85
Query: 114 HDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQL 173
H NIV++ A ++ME+ +L+ V++GA P A
Sbjct: 86 HPNIVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAH--------- 129
Query: 174 SLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANIL-ISEQDVCKISDFGCSEKLEDL 229
++ CL+ S G+ +LHS ++++H DLKP N+L ++ V KI DFG + +
Sbjct: 130 AMSWCLQCS----QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI--- 182
Query: 230 LCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPY---SGERQHI 286
QT G+ APE+ +G + K D++S+ I LW++ T++ P+ G I
Sbjct: 183 ---QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRI 239
Query: 287 LYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
++A V RP L +LP + + ++ RCW +QRPS ++ +T L
Sbjct: 240 MWA-VHNGTRPPLI-----KNLP-KPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 103 bits (256), Expect = 3e-22
Identities = 86/295 (29%), Positives = 148/295 (50%), Gaps = 46/295 (15%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN-VARLR 113
ID++++ + + +G G FG V KA +R VAIKQ+ ++ R++F EL ++R+
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE-----RKAFIVELRQLSRVN 85
Query: 114 HDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQL 173
H NIV++ A ++ME+ +L+ V++GA P A
Sbjct: 86 HPNIVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAH--------- 129
Query: 174 SLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANIL-ISEQDVCKISDFGCSEKLEDL 229
++ CL+ S G+ +LHS ++++H DLKP N+L ++ V KI DFG + +
Sbjct: 130 AMSWCLQCS----QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI--- 182
Query: 230 LCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPY---SGERQHI 286
QT G+ APE+ +G + K D++S+ I LW++ T++ P+ G I
Sbjct: 183 ---QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRI 239
Query: 287 LYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
++A V RP L +LP + + ++ RCW +QRPS ++ +T L
Sbjct: 240 MWA-VHNGTRPPLI-----KNLP-KPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 103 bits (256), Expect = 3e-22
Identities = 86/295 (29%), Positives = 148/295 (50%), Gaps = 46/295 (15%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN-VARLR 113
ID++++ + + +G G FG V KA +R VAIKQ+ ++ R++F EL ++R+
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE-----RKAFIVELRQLSRVN 85
Query: 114 HDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQL 173
H NIV++ A ++ME+ +L+ V++GA P A
Sbjct: 86 HPNIVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAH--------- 129
Query: 174 SLGKCLKYSLDVVNGLLFLHS---QSIVHLDLKPANIL-ISEQDVCKISDFGCSEKLEDL 229
++ CL+ S G+ +LHS ++++H DLKP N+L ++ V KI DFG + +
Sbjct: 130 AMSWCLQCS----QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI--- 182
Query: 230 LCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPY---SGERQHI 286
QT G+ APE+ +G + K D++S+ I LW++ T++ P+ G I
Sbjct: 183 ---QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRI 239
Query: 287 LYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
++A V RP L +LP + + ++ RCW +QRPS ++ +T L
Sbjct: 240 MWA-VHNGTRPPLI-----KNLP-KPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 138/285 (48%), Gaps = 39/285 (13%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVA 110
AW I E + L++RLGAG FG V+ Y + K K K S ++F E N+
Sbjct: 218 AW-EIPRESIKLVKRLGAGQFGEVWMGYYNN---STKVAVKTLKPGTMSVQAFLEEANLM 273
Query: 111 R-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRT 169
+ L+HD +VR+ A TR II E+ +L + G
Sbjct: 274 KTLQHDKLVRLYAVVTREEPIY-----IITEYMAKGSLLDFLKSDEG------------- 315
Query: 170 GGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLED- 228
G++ L K + +S + G+ ++ ++ +H DL+ AN+L+SE +CKI+DFG + +ED
Sbjct: 316 -GKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDN 374
Query: 229 -LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTT-KQAPYSGERQHI 286
+ +P+ T APE + T K+D++SF I L+++ T + PY G
Sbjct: 375 EYTAREGAKFPIKWT----APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD 430
Query: 287 LYAVVAYDLR-PSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ ++ R P + ++ P + L D+++ CW+ A +RP+
Sbjct: 431 VMTALSQGYRMPRV------ENCPDE-LYDIMKMCWKEKAEERPT 468
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 138/285 (48%), Gaps = 39/285 (13%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVA 110
AW I E + L++RLGAG FG V+ Y + K K K S ++F E N+
Sbjct: 239 AW-EIPRESIKLVKRLGAGQFGEVWMGYYNN---STKVAVKTLKPGTMSVQAFLEEANLM 294
Query: 111 R-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRT 169
+ L+HD +VR+ A TR II E+ +L + G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIY-----IITEYMAKGSLLDFLKSDEG------------- 336
Query: 170 GGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLED- 228
G++ L K + +S + G+ ++ ++ +H DL+ AN+L+SE +CKI+DFG + +ED
Sbjct: 337 -GKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDN 395
Query: 229 -LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTT-KQAPYSGERQHI 286
+ +P+ T APE + T K+D++SF I L+++ T + PY G
Sbjct: 396 EYTAREGAKFPIKWT----APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD 451
Query: 287 LYAVVAYDLR-PSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ ++ R P + ++ P + L D+++ CW+ A +RP+
Sbjct: 452 VMTALSQGYRMPRV------ENCPDE-LYDIMKMCWKEKAEERPT 489
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 99.0 bits (245), Expect = 6e-21
Identities = 85/286 (29%), Positives = 137/286 (47%), Gaps = 42/286 (14%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATY-RGVPVAIKQVNKCTKNRLASRRSFWAELNV 109
AW I E + L ++LGAG FG V+ ATY + VA+K + K S +F AE NV
Sbjct: 254 AW-EIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTM----KPGSMSVEAFLAEANV 308
Query: 110 AR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCR 168
+ L+HD +V++ A T+ P II EF +L + G +
Sbjct: 309 MKTLQHDKLVKLHAVVTKEPI------YIITEFMAKGSLLDFLKSDEGSKQ--------- 353
Query: 169 TGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLED 228
L K + +S + G+ F+ ++ +H DL+ ANIL+S VCKI+DFG + +ED
Sbjct: 354 -----PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIED 408
Query: 229 --LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTT-KQAPYSG-ERQ 284
+ +P+ T APE + T K+D++SF I L ++ T + PY G
Sbjct: 409 NEYTAREGAKFPIKWT----APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNP 464
Query: 285 HILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
++ A+ P ++ P + L +++ RCW+ +RP+
Sbjct: 465 EVIRALERGYRMPR------PENCP-EELYNIMMRCWKNRPEERPT 503
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 97.8 bits (242), Expect = 1e-20
Identities = 77/307 (25%), Positives = 141/307 (45%), Gaps = 57/307 (18%)
Query: 55 IDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIK--------QVNKCTKNRLASRRSFWAE 106
ID+ ++ L + +G GGFG VY+A + G VA+K +++ +N + F
Sbjct: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF--- 195
Query: 107 LNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPH 166
A L+H NI+ + + P ++MEF L++V+ G P+
Sbjct: 196 ---AMLKHPNIIALRGVCLKEPNLC-----LVMEFARGGPLNRVLSGKRIPPD------- 240
Query: 167 CRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIV---HLDLKPANILISEQ--------DVC 215
+ +++ + G+ +LH ++IV H DLK +NILI ++ +
Sbjct: 241 ----------ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKIL 290
Query: 216 KISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTK 275
KI+DFG + + +T GTY APE+++ + +D++S+ + LW++ T
Sbjct: 291 KITDFGLAREWH-----RTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTG 345
Query: 276 QAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLL 335
+ P+ G I VAY + + A + P + +++ CW P RPS +L
Sbjct: 346 EVPFRG----IDGLAVAYGVAMNKLALPIPSTCP-EPFAKLMEDCWNPDPHSRPSFTNIL 400
Query: 336 VDLTSLK 342
LT+++
Sbjct: 401 DQLTTIE 407
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 95.5 bits (236), Expect = 6e-20
Identities = 83/304 (27%), Positives = 137/304 (45%), Gaps = 42/304 (13%)
Query: 39 TLPRAPRLPRRLAWCSIDWE----QVCLLQRLGAGGFGSVYKATYR-GVPVAIKQVNKCT 93
TLP P+ W +WE + L+++LG+G FG V+ Y+ + VAIK + + T
Sbjct: 217 TLPCVRPAPQN-PWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGT 275
Query: 94 KNRLASRRSFWAELNVAR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIY 152
S +F E NV + L+H+ +VR+ A T+ P I+ E+ L +
Sbjct: 276 ----MSPEAFLGEANVMKALQHERLVRLYAVVTKEPI------YIVTEYMARGCLLDFL- 324
Query: 153 GAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQ 212
G +LSL + + S + G+ ++ + +H DL+ ANIL+SE
Sbjct: 325 -------------KTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEA 371
Query: 213 DVCKISDFGCSEKLE-DLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQ 271
CKI+DFG + ++ + + +P+ T APE + T KAD++SF + L +
Sbjct: 372 LCCKIADFGLARIIDSEYTAQEGAKFPIKWT----APEAIHFGVFTIKADVWSFGVLLME 427
Query: 272 MTT-KQAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ T + PY G + + R D+ P + VI CWR +RP+
Sbjct: 428 VVTYGRVPYPGMSNPEVIRNLERGYRMPR-----PDTCPPELYRGVIAECWRSRPEERPT 482
Query: 331 ARLL 334
L
Sbjct: 483 FEFL 486
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 95.1 bits (235), Expect = 8e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 43/288 (14%)
Query: 52 WCSIDWE----QVCLLQRLGAGGFGSVYKATYRG-VPVAIKQVNKCTKNRLASRRSFWAE 106
W +WE + L++RLGAG FG V+ Y G VA+K + K S +F AE
Sbjct: 233 WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSL----KQGSMSPDAFLAE 288
Query: 107 LNVAR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEP 165
N+ + L+H +VR+ A T+ P II E+ N +L + +G
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEPI------YIITEYMENGSLVDFLKTPSGI-------- 334
Query: 166 HCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
+L++ K L + + G+ F+ ++ +H DL+ ANIL+S+ CKI+DFG +
Sbjct: 335 ------KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARL 388
Query: 226 LED--LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTK-QAPYSGE 282
+ED + +P+ T APE + T K+D++SF I L ++ T + PY G
Sbjct: 389 IEDNEYTAREGAKFPIKWT----APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM 444
Query: 283 RQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ + R V D+ P + L +++ CW+ RP+
Sbjct: 445 TNPEVIQNLERGYR-----MVRPDNCP-EELYQLMRLCWKERPEDRPT 486
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 95.1 bits (235), Expect = 8e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 43/288 (14%)
Query: 52 WCSIDWE----QVCLLQRLGAGGFGSVYKATYRG-VPVAIKQVNKCTKNRLASRRSFWAE 106
W +WE + L++RLGAG FG V+ Y G VA+K + K S +F AE
Sbjct: 233 WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSL----KQGSMSPDAFLAE 288
Query: 107 LNVAR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEP 165
N+ + L+H +VR+ A T+ P II E+ N +L + +G
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEPI------YIITEYMENGSLVDFLKTPSGI-------- 334
Query: 166 HCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
+L++ K L + + G+ F+ ++ +H DL+ ANIL+S+ CKI+DFG +
Sbjct: 335 ------KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARL 388
Query: 226 LED--LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTK-QAPYSGE 282
+ED + +P+ T APE + T K+D++SF I L ++ T + PY G
Sbjct: 389 IEDNEYTAREGAKFPIKWT----APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM 444
Query: 283 RQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ + R V D+ P + L +++ CW+ RP+
Sbjct: 445 TNPEVIQNLERGYR-----MVRPDNCP-EELYQLMRLCWKERPEDRPT 486
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/290 (27%), Positives = 137/290 (47%), Gaps = 45/290 (15%)
Query: 58 EQVCLLQRLGAGGFGSVYKATYRGV-------PVAIKQVNKCTKNRLASRRS---FWAEL 107
EQ+ +++ LG G FG VY+ RG+ PVA+K VN+ LAS R F E
Sbjct: 977 EQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNE-----LASPRECIEFLKEA 1031
Query: 108 NVAR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPH 166
+V + + ++VR++ ++ G +L +IME L + E + G P
Sbjct: 1032 SVMKAFKCHHVVRLLGVVSQ---GQPTL--VIMELMTRGDLKSHLRSLRPEAENNPGLP- 1085
Query: 167 CRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKL 226
Q +LG+ ++ + ++ +G+ +L + VH DL N ++S+ KI DFG + +
Sbjct: 1086 -----QPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140
Query: 227 EDLLCFQTPSYPLGG----TYTHRAPELLKGEGVTPKADIYSFAITLWQMTT-KQAPYSG 281
++T Y GG APE LK T +D++SF + LW++ T + PY G
Sbjct: 1141 -----YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG 1195
Query: 282 -ERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPS 330
+ +L V+ + L + L +++ RCW+P+ RPS
Sbjct: 1196 LSNEQVLKFVMDGGVLEELEGCPLQ-------LQELMSRCWQPNPRLRPS 1238
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 94.7 bits (234), Expect = 1e-19
Identities = 74/297 (24%), Positives = 138/297 (46%), Gaps = 46/297 (15%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATY--RGVPVAIKQVNKCTKNRLASRRSFWAELN 108
++ I ++ + + G G FGSVY+A + + VA+K++ K K AE+
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKE---------AEI- 56
Query: 109 VARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCR 168
++ L H NI++ P I+ E+ +L+ I +
Sbjct: 57 LSVLSHRNIIQFYGVILEPPNYG-----IVTEYASLGSLYDYI--------------NSN 97
Query: 169 TGGQLSLGKCLKYSLDVVNGLLFLHSQS---IVHLDLKPANILISEQDVCKISDFGCSEK 225
++ + + ++ DV G+ +LH ++ ++H DLK N++I+ V KI DFG S
Sbjct: 98 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSG-ERQ 284
T L GT+ APE+++ V+ D YS+ + LW+M T++ P+ G E
Sbjct: 158 HN-----HTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGL 212
Query: 285 HILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
+ + VV + R ++ + S P + +++ +CW A +RPS + ++ L S+
Sbjct: 213 QVAWLVVEKNERLTIPS-----SCP-RSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 94.7 bits (234), Expect = 1e-19
Identities = 74/297 (24%), Positives = 138/297 (46%), Gaps = 46/297 (15%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATY--RGVPVAIKQVNKCTKNRLASRRSFWAELN 108
++ I ++ + + G G FGSVY+A + + VA+K++ K K AE+
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKE---------AEI- 56
Query: 109 VARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCR 168
++ L H NI++ P I+ E+ +L+ I +
Sbjct: 57 LSVLSHRNIIQFYGVILEPPNYG-----IVTEYASLGSLYDYI--------------NSN 97
Query: 169 TGGQLSLGKCLKYSLDVVNGLLFLHSQS---IVHLDLKPANILISEQDVCKISDFGCSEK 225
++ + + ++ DV G+ +LH ++ ++H DLK N++I+ V KI DFG S
Sbjct: 98 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSG-ERQ 284
T L GT+ APE+++ V+ D YS+ + LW+M T++ P+ G E
Sbjct: 158 HN-----HTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGL 212
Query: 285 HILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSL 341
+ + VV + R ++ + S P + +++ +CW A +RPS + ++ L S+
Sbjct: 213 QVAWLVVEKNERLTIPS-----SCP-RSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 93.2 bits (230), Expect = 3e-19
Identities = 80/287 (27%), Positives = 129/287 (44%), Gaps = 47/287 (16%)
Query: 56 DWEQVCLLQRLGAGGFGSVYKATYRG--VPVAIKQVNKCTKNRLASRRSFWAE--LNVAR 111
DW V +GGF V++A +R AIK + +S ++ E + +
Sbjct: 24 DWRLVA------SGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKK 77
Query: 112 LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGG 171
++ +IV + + P G I+MEF N +L +V+
Sbjct: 78 IKFQHIVSIYGVC-KQPLG------IVMEFMANGSLEKVLS------------------- 111
Query: 172 QLSLGKCLKYSLDVVN----GLLFLHS--QSIVHLDLKPANILISEQDVCKISDFGCSEK 225
+ C K +++ + FLHS ++HLDLKP NIL+ KISDFG S+
Sbjct: 112 --THSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKW 169
Query: 226 LEDLLCFQ-TPSYPLGGTYTHRAPELL--KGEGVTPKADIYSFAITLWQMTTKQAPYSGE 282
+E Q L G ++ PE+ + PK D+YSFAI +W++ T++ PYSG
Sbjct: 170 MEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGF 229
Query: 283 RQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRP 329
++ VA +RPSL + Q++ D+++RCW +RP
Sbjct: 230 NMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRP 276
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 92.0 bits (227), Expect = 7e-19
Identities = 84/289 (29%), Positives = 129/289 (44%), Gaps = 40/289 (13%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVP-VAIKQVNKCTKNRLASRRSFWAELNV 109
AW I E + L +LG G FG V+ T+ G VAIK + T S +F E V
Sbjct: 262 AW-EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM----SPEAFLQEAQV 316
Query: 110 AR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCR 168
+ LRH+ +V++ A + P I+ E+ +L + G
Sbjct: 317 MKKLRHEKLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKG--------------E 356
Query: 169 TGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLED 228
TG L L + + + + +G+ ++ + VH DL+ ANIL+ E VCK++DFG + +ED
Sbjct: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
Query: 229 --LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTK-QAPYSGERQH 285
Q +P+ T APE T K+D++SF I L ++TTK + PY G
Sbjct: 417 NEYTARQGAKFPIKWT----APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472
Query: 286 ILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL 334
+ V R E L D++ +CWR +RP+ L
Sbjct: 473 EVLDQVERGYRMPCPPECPES------LHDLMCQCWRKEPEERPTFEYL 515
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 92.0 bits (227), Expect = 7e-19
Identities = 84/289 (29%), Positives = 129/289 (44%), Gaps = 40/289 (13%)
Query: 51 AWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVP-VAIKQVNKCTKNRLASRRSFWAELNV 109
AW I E + L +LG G FG V+ T+ G VAIK + T S +F E V
Sbjct: 262 AW-EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM----SPEAFLQEAQV 316
Query: 110 AR-LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCR 168
+ LRH+ +V++ A + P I+ E+ +L + G
Sbjct: 317 MKKLRHEKLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKG--------------E 356
Query: 169 TGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLED 228
TG L L + + + + +G+ ++ + VH DL+ ANIL+ E VCK++DFG + +ED
Sbjct: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
Query: 229 --LLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTK-QAPYSGERQH 285
Q +P+ T APE T K+D++SF I L ++TTK + PY G
Sbjct: 417 NEYTARQGAKFPIKWT----APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472
Query: 286 ILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL 334
+ V R E L D++ +CWR +RP+ L
Sbjct: 473 EVLDQVERGYRMPCPPECPES------LHDLMCQCWRKEPEERPTFEYL 515
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 91.7 bits (226), Expect = 9e-19
Identities = 74/302 (24%), Positives = 133/302 (44%), Gaps = 45/302 (14%)
Query: 57 WEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLA-SRRSFWAELNV-ARLRH 114
++++ L + +G GGFG VY+ ++RG VA+K + ++ + S E + A L H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 115 DNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLS 174
NI+ + A P ++ME+ L + + G P
Sbjct: 174 PNIIALKAVCLEEPNLC-----LVMEYAAGGPLSRALAGRRVPPH--------------- 213
Query: 175 LGKCLKYSLDVVNGLLFLHSQSIV---HLDLKPANILI--------SEQDVCKISDFGCS 223
+ +++ + G+ +LH +++V H DLK NIL+ E KI+DFG +
Sbjct: 214 --VLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLA 271
Query: 224 EKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGER 283
+ +T GTY APE++K + +D++SF + LW++ T + PY G
Sbjct: 272 REWH-----KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRG-- 324
Query: 284 QHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKA 343
I VAY + + + P + ++ CW +RP +L L +L+A
Sbjct: 325 --IDCLAVAYGVAVNKLTLPIPSTCP-EPFAQLMADCWAQDPHRRPDFASILQQLEALEA 381
Query: 344 EL 345
++
Sbjct: 382 QV 383
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 91.3 bits (225), Expect = 1e-18
Identities = 76/302 (25%), Positives = 130/302 (43%), Gaps = 50/302 (16%)
Query: 41 PRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVN-KCTKNRLAS 99
P +LP+ + + + E++ +G GGFG VY+A +RG VA+K K+ +
Sbjct: 84 PAGLQLPQEIPFHELQLEEI-----IGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVT 138
Query: 100 RRSFWAELNV-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHP 158
E + L+H NI+ + A P ++ME+ L +V+ G P
Sbjct: 139 AEQVCQEARLFGALQHPNIIALRGACLNPPHLC-----LVMEYARGGALSRVLAGRRVPP 193
Query: 159 EGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQS---IVHLDLKPANILISE---- 211
+ +++ V G+ +LH+ + I+H DLK NILI E
Sbjct: 194 H-----------------VLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIEN 236
Query: 212 ----QDVCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAI 267
V KI+DFG + + +T GTY APE+++ + +D++SF +
Sbjct: 237 HNLADTVLKITDFGLAREWH-----KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV 291
Query: 268 TLWQMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQ 327
LW++ T + PY + I VAY + + + P + +++ CW P
Sbjct: 292 LLWELLTGEVPY----REIDALAVAYGVAMNKLTLPIPSTCP-EPFARLLEECWDPDPHG 346
Query: 328 RP 329
RP
Sbjct: 347 RP 348
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 90.9 bits (224), Expect = 2e-18
Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 48/292 (16%)
Query: 49 RLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN 108
R W ++ + + L ++G G FG+V + Y G VA+K + KC + ++F E
Sbjct: 184 RAGWL-LNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI-KCD----VTAQAFLDETA 237
Query: 109 V-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHC 167
V +++H+N+VR++ V LHQ +Y H
Sbjct: 238 VMTKMQHENLVRLLG----------------------VILHQGLYIVMEHVSKGNLVNFL 275
Query: 168 RTGGQ--LSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
RT G+ ++ + L++SL V G+ +L S+ +VH DL NIL+SE V K+SDFG ++
Sbjct: 276 RTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA 335
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQM-TTKQAPY-SGER 283
L + P+ T APE LK T K+D++SF + LW++ + +APY
Sbjct: 336 ERKGL--DSSRLPVKWT----APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSL 389
Query: 284 QHILYAV-VAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL 334
+ + AV Y + P + PG + ++ CW A+RP R L
Sbjct: 390 KEVSEAVEKGYRMEP-------PEGCPGP-VHVLMSSCWEAEPARRPPFRKL 433
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 90.9 bits (224), Expect = 2e-18
Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 48/292 (16%)
Query: 49 RLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN 108
R W ++ + + L ++G G FG+V + Y G VA+K + KC + ++F E
Sbjct: 226 RAGWL-LNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI-KCD----VTAQAFLDETA 279
Query: 109 V-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHC 167
V +++H+N+VR++ V LHQ +Y H
Sbjct: 280 VMTKMQHENLVRLLG----------------------VILHQGLYIVMEHVSKGNLVNFL 317
Query: 168 RTGGQ--LSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
RT G+ ++ + L++SL V G+ +L S+ +VH DL NIL+SE V K+SDFG ++
Sbjct: 318 RTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA 377
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQM-TTKQAPY-SGER 283
L + P+ T APE LK T K+D++SF + LW++ + +APY
Sbjct: 378 ERKGL--DSSRLPVKWT----APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSL 431
Query: 284 QHILYAV-VAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL 334
+ + AV Y + P + PG + ++ CW A+RP R L
Sbjct: 432 KEVSEAVEKGYRMEP-------PEGCPGP-VHVLMSSCWEAEPARRPPFRKL 475
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 90.9 bits (224), Expect = 2e-18
Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 48/292 (16%)
Query: 49 RLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELN 108
R W ++ + + L ++G G FG+V + Y G VA+K + KC + ++F E
Sbjct: 225 RAGWL-LNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI-KCD----VTAQAFLDETA 278
Query: 109 V-ARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHC 167
V +++H+N+VR++ V LHQ +Y H
Sbjct: 279 VMTKMQHENLVRLLG----------------------VILHQGLYIVMEHVSKGNLVNFL 316
Query: 168 RTGGQ--LSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEK 225
RT G+ ++ + L++SL V G+ +L S+ +VH DL NIL+SE V K+SDFG ++
Sbjct: 317 RTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA 376
Query: 226 LEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQM-TTKQAPY-SGER 283
L + P+ T APE LK T K+D++SF + LW++ + +APY
Sbjct: 377 ERKGL--DSSRLPVKWT----APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSL 430
Query: 284 QHILYAV-VAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL 334
+ + AV Y + P + PG + ++ CW A+RP R L
Sbjct: 431 KEVSEAVEKGYRMEP-------PEGCPGP-VHVLMSSCWEAEPARRPPFRKL 474
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 89.7 bits (221), Expect = 3e-18
Identities = 83/295 (28%), Positives = 129/295 (43%), Gaps = 33/295 (11%)
Query: 46 LPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKA--TYRGVPVAIKQVNKCTKNRLASRRSF 103
+P + I+W + LL G G FG VY G +A KQV + S+
Sbjct: 382 VPTKSPSAPINWRRGKLL---GQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVS 438
Query: 104 WAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEF--GGNVTLHQVIYGAAGHPEGD 161
E + L++ R+V + TI ME+ GG+V YGA
Sbjct: 439 ALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA------- 491
Query: 162 AGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFG 221
L+ KY+ ++ G+ +LHS IVH D+K ANIL K+ DFG
Sbjct: 492 -----------LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG 540
Query: 222 CSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSG 281
S++L+ + T + GT +PE++ GEG KAD++S T+ +M T++ P++
Sbjct: 541 ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 600
Query: 282 -ERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLL 335
E ++ + P L + + E D ++R + A QRPSA LL
Sbjct: 601 YEAMAAIFKIATQPTNPQLPSHISEHG------RDFLRRIF-VEARQRPSAEELL 648
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 89.7 bits (221), Expect = 3e-18
Identities = 83/295 (28%), Positives = 129/295 (43%), Gaps = 33/295 (11%)
Query: 46 LPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKA--TYRGVPVAIKQVNKCTKNRLASRRSF 103
+P + I+W + LL G G FG VY G +A KQV + S+
Sbjct: 351 VPTKSPSAPINWRRGKLL---GQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVS 407
Query: 104 WAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEF--GGNVTLHQVIYGAAGHPEGD 161
E + L++ R+V + TI ME+ GG+V YGA
Sbjct: 408 ALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA------- 460
Query: 162 AGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFG 221
L+ KY+ ++ G+ +LHS IVH D+K ANIL K+ DFG
Sbjct: 461 -----------LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG 509
Query: 222 CSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSG 281
S++L+ + T + GT +PE++ GEG KAD++S T+ +M T++ P++
Sbjct: 510 ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569
Query: 282 -ERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLL 335
E ++ + P L + + E D ++R + A QRPSA LL
Sbjct: 570 YEAMAAIFKIATQPTNPQLPSHISEHG------RDFLRRIF-VEARQRPSAEELL 617
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,335,624
Number of Sequences: 37866
Number of extensions: 701634
Number of successful extensions: 3146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 687
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 1522
Number of HSP's gapped (non-prelim): 1003
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.