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Search of human proteins with 4885399
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885399 structural maintenance of chromosomes 3 [Homo
sapiens]
(1217 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 2366 0.0
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 316 7e-86
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 316 7e-86
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 316 7e-86
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 237 6e-62
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 237 6e-62
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 229 2e-59
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 192 2e-48
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 120 8e-27
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 119 2e-26
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 118 4e-26
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 117 7e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 117 7e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 117 7e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 117 7e-26
gi|156104908 myosin heavy chain 6 [Homo sapiens] 117 9e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 115 2e-25
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 115 3e-25
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 114 7e-25
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 114 7e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 112 3e-24
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 111 4e-24
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 111 4e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 110 8e-24
gi|71061468 centromere protein E [Homo sapiens] 108 2e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 108 3e-23
gi|55770834 centromere protein F [Homo sapiens] 108 4e-23
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 107 7e-23
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 107 9e-23
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 104 4e-22
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 2366 bits (6132), Expect = 0.0
Identities = 1217/1217 (100%), Positives = 1217/1217 (100%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ 60
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ
Sbjct: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ 60
Query: 61 RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND 120
RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND
Sbjct: 61 RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND 120
Query: 121 VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK 180
VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK
Sbjct: 121 VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK 180
Query: 181 ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLD 240
ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLD
Sbjct: 181 ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLD 240
Query: 241 ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIK 300
ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIK
Sbjct: 241 ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIK 300
Query: 301 QRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER 360
QRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER
Sbjct: 301 QRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER 360
Query: 361 GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL 420
GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL
Sbjct: 361 GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL 420
Query: 421 EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ 480
EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ
Sbjct: 421 EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ 480
Query: 481 QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF 540
QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF
Sbjct: 481 QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF 540
Query: 541 ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY 600
ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY
Sbjct: 541 ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY 600
Query: 601 PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH 660
PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH
Sbjct: 601 PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH 660
Query: 661 RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ 720
RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ
Sbjct: 661 RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ 720
Query: 721 IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE 780
IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE
Sbjct: 721 IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE 780
Query: 781 LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL 840
LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL
Sbjct: 781 LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL 840
Query: 841 DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKS 900
DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKS
Sbjct: 841 DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKS 900
Query: 901 MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL 960
MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL
Sbjct: 901 MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL 960
Query: 961 SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV 1020
SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV
Sbjct: 961 SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV 1020
Query: 1021 LELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERG 1080
LELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERG
Sbjct: 1021 LELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERG 1080
Query: 1081 SGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFY 1140
SGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFY
Sbjct: 1081 SGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFY 1140
Query: 1141 LFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDV 1200
LFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDV
Sbjct: 1141 LFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDV 1200
Query: 1201 ITAEMAKDFVEDDTTHG 1217
ITAEMAKDFVEDDTTHG
Sbjct: 1201 ITAEMAKDFVEDDTTHG 1217
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 316 bits (810), Expect = 7e-86
Identities = 310/1266 (24%), Positives = 580/1266 (45%), Gaps = 166/1266 (13%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPE 59
M+IK +I++GF+SY +T V+ F N I G NGSGKSN +I F+L S +R
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 60 QRLALLHEGTGPRVISAFVEIIFDNSDNR-----LPIDKEEVSLRRVIGAKKDQYFLDKK 114
L+++ + A V I FDNSD + + E R+V+ +++Y ++
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 115 MVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEE 174
V +L S G + +NP++++ QG+I ++ + L ++ E AGTR+Y+ +K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKK-- 178
Query: 175 SISLMKETEGKREKINELLKYIEERLH-TLEEEKEELAQYQKWDKMRRALEYTIYNQELN 233
I+ K E K K+ E+ +EE + T+++ KEE + Y ++ K+ R +E+ L+
Sbjct: 179 -IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH------LS 231
Query: 234 ETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSA 293
L A+ +T + +L++ Q DK+ ++ ++ E KI A+ E E+L
Sbjct: 232 RLYIAYQFLLAE-DTKVRSAEELKEMQ----DKVIKLQEELSENDKKIKALNHEIEELEK 286
Query: 294 ERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET---EPK 350
+ K+ + +D E + + + ++K L E K+KEL + + K
Sbjct: 287 RKD---KETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
Query: 351 FNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSL-DQAINDK 409
+ KEKE + I A QE ++ A+ + ++ + L S D A
Sbjct: 344 TLAAKEKEVKKITDGLHALQEASNKDAEA-----LAAAQQHFNAVSAGLSSNEDGAEATL 398
Query: 410 KRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE-------VKNKK 462
Q+ A D+ + ++ + Q+L +A V+++D Y + VK K
Sbjct: 399 AGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
Query: 463 DELQSERNYLWREENAEQQALAAKREDLEKKQQLLR-----AATGKAILNGIDSINKVLD 517
++L++E L EEN E+ L EK++QL R T +A+L ++
Sbjct: 459 EKLEAEMKKLNYEENKEESLL-------EKRRQLSRDIGRLKETYEALLARFPNLRFAYK 511
Query: 518 HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFN 577
K N++ G +++ + T +E+ AG RL+ +VD++ K+L
Sbjct: 512 D-PEKNWNRNCVKGLVASLISVKDTSAT--TALELVAGERLYNVVVDTEVTGKKLL---E 565
Query: 578 KMNLPGEVTFLPLNKLDVRDTAYPET----------NDAIPMISKLRYNPRFDKAFKHVF 627
+ L T +PLNK+ R A PET ++ +S + Y P KA + VF
Sbjct: 566 RGELKRRYTIIPLNKISARCIA-PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF 624
Query: 628 GKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKSRL-------EL 678
G T +C +M+ + ++A + +TL GD G L+GG S L ++
Sbjct: 625 GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV 684
Query: 679 QKDVRKAEEELGELEAKLN---------ENLRRNIERINNEIDQLMNQMQQ--IETQQRK 727
Q ++R E EL LE +L L++ E E D L ++QQ QQ +
Sbjct: 685 QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
Query: 728 FKASRDSILSE---MKMLKEKRQQSEKTFMPKQRSLQSLEASLHA-MESTRESLK-AELG 782
A + +I +K KE ++++E+ + + +++ EA ++ ++ L A+
Sbjct: 745 LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804
Query: 783 TDLLSQLSLEDQKRVDALNDEIRQLQQENR------QLLNERIK-LEGIITRVETYLNEN 835
D S+ E Q+ V+A+ E+ +L++E+ + +NE IK E I + + +N
Sbjct: 805 ADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
Query: 836 LRKRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAG 893
++ +++ ++E+ + +E T TV+ A +E+ ++ D+ + ++LD++I K +
Sbjct: 865 -KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHK-- 921
Query: 894 IKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEA 953
+E + + M K++ D IN + R L P A
Sbjct: 922 -REAEDGAAKVSKMLKDY-DWINAE-------------------------RHLFGQPNSA 954
Query: 954 FEKYQTLSLKQLFRKLEQCNTELKKYS-HVNKKALDQFVNFSEQKEKLIKRQEELDRGYK 1012
++ ++T + K+ ++L++ +K +VN +A++ E+ L+K++ ++
Sbjct: 955 YD-FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKS 1013
Query: 1013 SIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGE 1072
I+ + L+ +K +A+ + +++V+K+F +F L+PG A L +G
Sbjct: 1014 KILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTV--------- 1064
Query: 1073 GSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQ 1132
G+ +V+ E + +LSGGQ+SLVAL+LI ++
Sbjct: 1065 --------------------LDGLEFKVALGNTWKE--NLTELSGGQRSLVALSLILSML 1102
Query: 1133 KCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFR 1192
PAP Y+ DE+D ALD H + + M+ H+QFI + + + +A+ + KF
Sbjct: 1103 LFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFV 1162
Query: 1193 NKVSHI 1198
+ VS +
Sbjct: 1163 DGVSTV 1168
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 316 bits (810), Expect = 7e-86
Identities = 310/1266 (24%), Positives = 580/1266 (45%), Gaps = 166/1266 (13%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPE 59
M+IK +I++GF+SY +T V+ F N I G NGSGKSN +I F+L S +R
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 60 QRLALLHEGTGPRVISAFVEIIFDNSDNR-----LPIDKEEVSLRRVIGAKKDQYFLDKK 114
L+++ + A V I FDNSD + + E R+V+ +++Y ++
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 115 MVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEE 174
V +L S G + +NP++++ QG+I ++ + L ++ E AGTR+Y+ +K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKK-- 178
Query: 175 SISLMKETEGKREKINELLKYIEERLH-TLEEEKEELAQYQKWDKMRRALEYTIYNQELN 233
I+ K E K K+ E+ +EE + T+++ KEE + Y ++ K+ R +E+ L+
Sbjct: 179 -IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH------LS 231
Query: 234 ETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSA 293
L A+ +T + +L++ Q DK+ ++ ++ E KI A+ E E+L
Sbjct: 232 RLYIAYQFLLAE-DTKVRSAEELKEMQ----DKVIKLQEELSENDKKIKALNHEIEELEK 286
Query: 294 ERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET---EPK 350
+ K+ + +D E + + + ++K L E K+KEL + + K
Sbjct: 287 RKD---KETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
Query: 351 FNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSL-DQAINDK 409
+ KEKE + I A QE ++ A+ + ++ + L S D A
Sbjct: 344 TLAAKEKEVKKITDGLHALQEASNKDAEA-----LAAAQQHFNAVSAGLSSNEDGAEATL 398
Query: 410 KRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE-------VKNKK 462
Q+ A D+ + ++ + Q+L +A V+++D Y + VK K
Sbjct: 399 AGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
Query: 463 DELQSERNYLWREENAEQQALAAKREDLEKKQQLLR-----AATGKAILNGIDSINKVLD 517
++L++E L EEN E+ L EK++QL R T +A+L ++
Sbjct: 459 EKLEAEMKKLNYEENKEESLL-------EKRRQLSRDIGRLKETYEALLARFPNLRFAYK 511
Query: 518 HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFN 577
K N++ G +++ + T +E+ AG RL+ +VD++ K+L
Sbjct: 512 D-PEKNWNRNCVKGLVASLISVKDTSAT--TALELVAGERLYNVVVDTEVTGKKLL---E 565
Query: 578 KMNLPGEVTFLPLNKLDVRDTAYPET----------NDAIPMISKLRYNPRFDKAFKHVF 627
+ L T +PLNK+ R A PET ++ +S + Y P KA + VF
Sbjct: 566 RGELKRRYTIIPLNKISARCIA-PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF 624
Query: 628 GKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKSRL-------EL 678
G T +C +M+ + ++A + +TL GD G L+GG S L ++
Sbjct: 625 GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV 684
Query: 679 QKDVRKAEEELGELEAKLN---------ENLRRNIERINNEIDQLMNQMQQ--IETQQRK 727
Q ++R E EL LE +L L++ E E D L ++QQ QQ +
Sbjct: 685 QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
Query: 728 FKASRDSILSE---MKMLKEKRQQSEKTFMPKQRSLQSLEASLHA-MESTRESLK-AELG 782
A + +I +K KE ++++E+ + + +++ EA ++ ++ L A+
Sbjct: 745 LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804
Query: 783 TDLLSQLSLEDQKRVDALNDEIRQLQQENR------QLLNERIK-LEGIITRVETYLNEN 835
D S+ E Q+ V+A+ E+ +L++E+ + +NE IK E I + + +N
Sbjct: 805 ADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
Query: 836 LRKRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAG 893
++ +++ ++E+ + +E T TV+ A +E+ ++ D+ + ++LD++I K +
Sbjct: 865 -KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHK-- 921
Query: 894 IKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEA 953
+E + + M K++ D IN + R L P A
Sbjct: 922 -REAEDGAAKVSKMLKDY-DWINAE-------------------------RHLFGQPNSA 954
Query: 954 FEKYQTLSLKQLFRKLEQCNTELKKYS-HVNKKALDQFVNFSEQKEKLIKRQEELDRGYK 1012
++ ++T + K+ ++L++ +K +VN +A++ E+ L+K++ ++
Sbjct: 955 YD-FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKS 1013
Query: 1013 SIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGE 1072
I+ + L+ +K +A+ + +++V+K+F +F L+PG A L +G
Sbjct: 1014 KILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTV--------- 1064
Query: 1073 GSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQ 1132
G+ +V+ E + +LSGGQ+SLVAL+LI ++
Sbjct: 1065 --------------------LDGLEFKVALGNTWKE--NLTELSGGQRSLVALSLILSML 1102
Query: 1133 KCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFR 1192
PAP Y+ DE+D ALD H + + M+ H+QFI + + + +A+ + KF
Sbjct: 1103 LFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFV 1162
Query: 1193 NKVSHI 1198
+ VS +
Sbjct: 1163 DGVSTV 1168
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 316 bits (810), Expect = 7e-86
Identities = 310/1266 (24%), Positives = 580/1266 (45%), Gaps = 166/1266 (13%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPE 59
M+IK +I++GF+SY +T V+ F N I G NGSGKSN +I F+L S +R
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 60 QRLALLHEGTGPRVISAFVEIIFDNSDNR-----LPIDKEEVSLRRVIGAKKDQYFLDKK 114
L+++ + A V I FDNSD + + E R+V+ +++Y ++
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 115 MVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEE 174
V +L S G + +NP++++ QG+I ++ + L ++ E AGTR+Y+ +K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKK-- 178
Query: 175 SISLMKETEGKREKINELLKYIEERLH-TLEEEKEELAQYQKWDKMRRALEYTIYNQELN 233
I+ K E K K+ E+ +EE + T+++ KEE + Y ++ K+ R +E+ L+
Sbjct: 179 -IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH------LS 231
Query: 234 ETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSA 293
L A+ +T + +L++ Q DK+ ++ ++ E KI A+ E E+L
Sbjct: 232 RLYIAYQFLLAE-DTKVRSAEELKEMQ----DKVIKLQEELSENDKKIKALNHEIEELEK 286
Query: 294 ERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET---EPK 350
+ K+ + +D E + + + ++K L E K+KEL + + K
Sbjct: 287 RKD---KETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
Query: 351 FNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSL-DQAINDK 409
+ KEKE + I A QE ++ A+ + ++ + L S D A
Sbjct: 344 TLAAKEKEVKKITDGLHALQEASNKDAEA-----LAAAQQHFNAVSAGLSSNEDGAEATL 398
Query: 410 KRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE-------VKNKK 462
Q+ A D+ + ++ + Q+L +A V+++D Y + VK K
Sbjct: 399 AGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
Query: 463 DELQSERNYLWREENAEQQALAAKREDLEKKQQLLR-----AATGKAILNGIDSINKVLD 517
++L++E L EEN E+ L EK++QL R T +A+L ++
Sbjct: 459 EKLEAEMKKLNYEENKEESLL-------EKRRQLSRDIGRLKETYEALLARFPNLRFAYK 511
Query: 518 HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFN 577
K N++ G +++ + T +E+ AG RL+ +VD++ K+L
Sbjct: 512 D-PEKNWNRNCVKGLVASLISVKDTSAT--TALELVAGERLYNVVVDTEVTGKKLL---E 565
Query: 578 KMNLPGEVTFLPLNKLDVRDTAYPET----------NDAIPMISKLRYNPRFDKAFKHVF 627
+ L T +PLNK+ R A PET ++ +S + Y P KA + VF
Sbjct: 566 RGELKRRYTIIPLNKISARCIA-PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF 624
Query: 628 GKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKSRL-------EL 678
G T +C +M+ + ++A + +TL GD G L+GG S L ++
Sbjct: 625 GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV 684
Query: 679 QKDVRKAEEELGELEAKLN---------ENLRRNIERINNEIDQLMNQMQQ--IETQQRK 727
Q ++R E EL LE +L L++ E E D L ++QQ QQ +
Sbjct: 685 QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
Query: 728 FKASRDSILSE---MKMLKEKRQQSEKTFMPKQRSLQSLEASLHA-MESTRESLK-AELG 782
A + +I +K KE ++++E+ + + +++ EA ++ ++ L A+
Sbjct: 745 LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804
Query: 783 TDLLSQLSLEDQKRVDALNDEIRQLQQENR------QLLNERIK-LEGIITRVETYLNEN 835
D S+ E Q+ V+A+ E+ +L++E+ + +NE IK E I + + +N
Sbjct: 805 ADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
Query: 836 LRKRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAG 893
++ +++ ++E+ + +E T TV+ A +E+ ++ D+ + ++LD++I K +
Sbjct: 865 -KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHK-- 921
Query: 894 IKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEA 953
+E + + M K++ D IN + R L P A
Sbjct: 922 -REAEDGAAKVSKMLKDY-DWINAE-------------------------RHLFGQPNSA 954
Query: 954 FEKYQTLSLKQLFRKLEQCNTELKKYS-HVNKKALDQFVNFSEQKEKLIKRQEELDRGYK 1012
++ ++T + K+ ++L++ +K +VN +A++ E+ L+K++ ++
Sbjct: 955 YD-FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKS 1013
Query: 1013 SIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGE 1072
I+ + L+ +K +A+ + +++V+K+F +F L+PG A L +G
Sbjct: 1014 KILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTV--------- 1064
Query: 1073 GSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQ 1132
G+ +V+ E + +LSGGQ+SLVAL+LI ++
Sbjct: 1065 --------------------LDGLEFKVALGNTWKE--NLTELSGGQRSLVALSLILSML 1102
Query: 1133 KCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFR 1192
PAP Y+ DE+D ALD H + + M+ H+QFI + + + +A+ + KF
Sbjct: 1103 LFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFV 1162
Query: 1193 NKVSHI 1198
+ VS +
Sbjct: 1163 DGVSTV 1168
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 237 bits (604), Expect = 6e-62
Identities = 276/1278 (21%), Positives = 563/1278 (44%), Gaps = 148/1278 (11%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ 60
+ I ++ Q F+SY + I+ PF + + I+G NGSGKSN ++ FV +R ++
Sbjct: 82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKK 141
Query: 61 RLALLHEGTGPRVI-SAFVEIIFDNSDNRLPIDKEEVS------LRRVIGAKKDQYFLDK 113
L+H + I S VE+ F ++ D E + R Y +
Sbjct: 142 LSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISG 201
Query: 114 KMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMA-------TAPDSQRLKLLREVAGTR 166
K T DV NLL S G + +++ QG++ Q+A T D L+ L ++ G
Sbjct: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
Query: 167 VYDERKE---ESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-----QKWDK 218
+E + + ++ E G EK+N + K +E+ LE EK ++ + + K
Sbjct: 262 RLNEPIKVLCRRVEILNEHRG--EKLNRV-KMVEKEKDALEGEKNIAIEFLTLENEIFRK 318
Query: 219 MRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELK 278
+Y IY E + ++ E+ ++E E ++++ + ++M+ + V++ +
Sbjct: 319 KNHVCQYYIY-----ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTE 373
Query: 279 TKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE 338
K++ + + E E ++ T+L+L+ ++++L + + K+L K+ QK EK+E
Sbjct: 374 KKLNKITKFIE-------ENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVE 426
Query: 339 E-------KQKELAETEPKFNSV---KEKEERGIARLAQATQERTDLYAKQGRGSQFTSK 388
E + ET + N++ KEKEE+ + + + ++ T K+ K
Sbjct: 427 EFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKE--------K 478
Query: 389 EERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKL-------DQDL 441
E R+K EL +++N+ + ++ +L+ + + Q K + L
Sbjct: 479 ESREK----ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETL 534
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAAT 501
E KA + +++ K + + + E + E L +EE + + + +E+ + L A
Sbjct: 535 KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSL--AM 592
Query: 502 GKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH 561
++ +D+I + R GI + G G + ++ A +C L Y
Sbjct: 593 NRSRGKVLDAIIQEKKSGRIPGIYGRL--GDLGAIDEKYDV--AISSCCHA-----LDYI 643
Query: 562 IVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDV-----RDTAYPETNDAIPMISKLRYN 616
+VDS +++ + + + N+ G TF+ L+K+ V + PE + + K++ +
Sbjct: 644 VVDSIDIAQECVNFLKRQNI-GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVK-D 701
Query: 617 PRFDKAFKHVFGKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKS 674
+ +AF TL+ +++ +T++A + +TL+G + G +TGG K
Sbjct: 702 EKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKG 761
Query: 675 RLELQKDVRKAEEELGELEAKLNENLRRNIE------RINNEIDQLMNQMQQIETQQRKF 728
R+ + +EEE+ ++E++L + ++ ++ ++ + +L + +++ KF
Sbjct: 762 RMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKF 821
Query: 729 KASRDSILSEMKMLKEKRQQSEKTFM---PKQRSLQSLEASLHAMESTRESLKAELGTDL 785
AS ++ + + L + ++ E + P ++ + LE ++ A ++ +++ + G
Sbjct: 822 TASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
Query: 786 LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERI-KLEGIITRVETYL---NENLRKRLD 841
L + + +N+ + QQ+ +N+++ + IT+ + + + NL+K D
Sbjct: 882 AEVKRLHNT--IVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Query: 842 QVEQELNELRETEGGTVLTATTSELEAINKR----VKDTMARSEDLDNSIDKTEAGIKEL 897
V + E+++TE + T+EL+++ + VK+T A E L + ++EL
Sbjct: 940 SVLRTEKEIKDTE--KEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQEL 997
Query: 898 QKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKY 957
+ E ++K+ + +I ++++ +K + + KI L + E+
Sbjct: 998 KVIQENEHALQKDAL-SIKLKLEQIDGHIAEHNSKIKYWHKEISKI-SLHPIEDNPIEEI 1055
Query: 958 QTLSLKQL--FRKLEQCNTE---LKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDR--- 1009
LS + L + + + L+ H K L + +++E ++R ELD+
Sbjct: 1056 SVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITY 1115
Query: 1010 GYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQD 1069
S + L ++ F ++ E +Q L GG A L +
Sbjct: 1116 ERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELEL------------ 1163
Query: 1070 EGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIF 1129
V S+D F+ GI S + +++ LSGG+K+L +LAL+F
Sbjct: 1164 -----------------VDSLDPFSE-GIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVF 1205
Query: 1130 AIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGV 1189
A+ P P Y DEID ALD ++ V+ I E +AQFI + R + E +D+ G+
Sbjct: 1206 ALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1265
Query: 1190 -KFRNKVSHIDVITAEMA 1206
K N + V E+A
Sbjct: 1266 YKTYNITKSVAVNPKEIA 1283
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 237 bits (604), Expect = 6e-62
Identities = 276/1278 (21%), Positives = 563/1278 (44%), Gaps = 148/1278 (11%)
Query: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ 60
+ I ++ Q F+SY + I+ PF + + I+G NGSGKSN ++ FV +R ++
Sbjct: 82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKK 141
Query: 61 RLALLHEGTGPRVI-SAFVEIIFDNSDNRLPIDKEEVS------LRRVIGAKKDQYFLDK 113
L+H + I S VE+ F ++ D E + R Y +
Sbjct: 142 LSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISG 201
Query: 114 KMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMA-------TAPDSQRLKLLREVAGTR 166
K T DV NLL S G + +++ QG++ Q+A T D L+ L ++ G
Sbjct: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
Query: 167 VYDERKE---ESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-----QKWDK 218
+E + + ++ E G EK+N + K +E+ LE EK ++ + + K
Sbjct: 262 RLNEPIKVLCRRVEILNEHRG--EKLNRV-KMVEKEKDALEGEKNIAIEFLTLENEIFRK 318
Query: 219 MRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELK 278
+Y IY E + ++ E+ ++E E ++++ + ++M+ + V++ +
Sbjct: 319 KNHVCQYYIY-----ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTE 373
Query: 279 TKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE 338
K++ + + E E ++ T+L+L+ ++++L + + K+L K+ QK EK+E
Sbjct: 374 KKLNKITKFIE-------ENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVE 426
Query: 339 E-------KQKELAETEPKFNSV---KEKEERGIARLAQATQERTDLYAKQGRGSQFTSK 388
E + ET + N++ KEKEE+ + + + ++ T K+ K
Sbjct: 427 EFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKE--------K 478
Query: 389 EERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKL-------DQDL 441
E R+K EL +++N+ + ++ +L+ + + Q K + L
Sbjct: 479 ESREK----ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETL 534
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAAT 501
E KA + +++ K + + + E + E L +EE + + + +E+ + L A
Sbjct: 535 KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSL--AM 592
Query: 502 GKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH 561
++ +D+I + R GI + G G + ++ A +C L Y
Sbjct: 593 NRSRGKVLDAIIQEKKSGRIPGIYGRL--GDLGAIDEKYDV--AISSCCHA-----LDYI 643
Query: 562 IVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDV-----RDTAYPETNDAIPMISKLRYN 616
+VDS +++ + + + N+ G TF+ L+K+ V + PE + + K++ +
Sbjct: 644 VVDSIDIAQECVNFLKRQNI-GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVK-D 701
Query: 617 PRFDKAFKHVFGKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKS 674
+ +AF TL+ +++ +T++A + +TL+G + G +TGG K
Sbjct: 702 EKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKG 761
Query: 675 RLELQKDVRKAEEELGELEAKLNENLRRNIE------RINNEIDQLMNQMQQIETQQRKF 728
R+ + +EEE+ ++E++L + ++ ++ ++ + +L + +++ KF
Sbjct: 762 RMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKF 821
Query: 729 KASRDSILSEMKMLKEKRQQSEKTFM---PKQRSLQSLEASLHAMESTRESLKAELGTDL 785
AS ++ + + L + ++ E + P ++ + LE ++ A ++ +++ + G
Sbjct: 822 TASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
Query: 786 LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERI-KLEGIITRVETYL---NENLRKRLD 841
L + + +N+ + QQ+ +N+++ + IT+ + + + NL+K D
Sbjct: 882 AEVKRLHNT--IVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Query: 842 QVEQELNELRETEGGTVLTATTSELEAINKR----VKDTMARSEDLDNSIDKTEAGIKEL 897
V + E+++TE + T+EL+++ + VK+T A E L + ++EL
Sbjct: 940 SVLRTEKEIKDTE--KEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQEL 997
Query: 898 QKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKY 957
+ E ++K+ + +I ++++ +K + + KI L + E+
Sbjct: 998 KVIQENEHALQKDAL-SIKLKLEQIDGHIAEHNSKIKYWHKEISKI-SLHPIEDNPIEEI 1055
Query: 958 QTLSLKQL--FRKLEQCNTE---LKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDR--- 1009
LS + L + + + L+ H K L + +++E ++R ELD+
Sbjct: 1056 SVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITY 1115
Query: 1010 GYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQD 1069
S + L ++ F ++ E +Q L GG A L +
Sbjct: 1116 ERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELEL------------ 1163
Query: 1070 EGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIF 1129
V S+D F+ GI S + +++ LSGG+K+L +LAL+F
Sbjct: 1164 -----------------VDSLDPFSE-GIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVF 1205
Query: 1130 AIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGV 1189
A+ P P Y DEID ALD ++ V+ I E +AQFI + R + E +D+ G+
Sbjct: 1206 ALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1265
Query: 1190 -KFRNKVSHIDVITAEMA 1206
K N + V E+A
Sbjct: 1266 YKTYNITKSVAVNPKEIA 1283
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 229 bits (583), Expect = 2e-59
Identities = 290/1284 (22%), Positives = 557/1284 (43%), Gaps = 179/1284 (13%)
Query: 2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQR 61
++K + I+ F+SY+ + I+ PF + I+G NGSGKSN AI FVL ++ S+LR +
Sbjct: 3 FLKLIEIENFKSYKGRQIIGPFQ-RFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTL 61
Query: 62 LALLHEGT--GPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKN 119
L+H P AFV +++ E+ + RVI +Y ++ K+V +
Sbjct: 62 RDLIHGAPVGKPAANRAFVSMVYSEEG------AEDRTFARVIVGGSSEYKINNKVVQLH 115
Query: 120 DVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLM 179
+ LE G ++V QG + +A +R L E++
Sbjct: 116 EYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEIS---------------- 159
Query: 180 KETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKL 239
ELAQ ++DK ++ + + + N R K
Sbjct: 160 --------------------------RSGELAQ--EYDKRKKEMVKAEEDTQFNYHRKK- 190
Query: 240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQI 299
++A+R+ E ++ +A + R K E + QV+ K+ + E E+L+ E +
Sbjct: 191 -NIAAERK---EAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKN 246
Query: 300 KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEE 359
K+ K + + ++DEL ++ ++++E+Q++ ++I+EK EL + P++ KE
Sbjct: 247 KEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTS 306
Query: 360 RGIARL--AQATQERTDLYAKQGRG----------SQFTSKEERDKWIKKELKSLDQAIN 407
I +L A+ + + + K+ +G S +++E ++ +++E +S + +
Sbjct: 307 HKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLT 366
Query: 408 DKKRQIAAIHKDLEDTE---ANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDE 464
++ Q+ H+ E+ A + LE++N+ DQ ++ + +EE + E K K+
Sbjct: 367 LEENQVKKYHRLKEEASKRAATLAQELEKFNR-DQKADQDRLDLEERKKVETEAKIKQKL 425
Query: 465 LQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAIL--NGIDSINKVLDHF--- 519
+ E N R E E+ + ++ LE++++L T + + ID INK L+
Sbjct: 426 REIEENQK-RIEKLEEY-ITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQ 483
Query: 520 ---------------RRKGINQHVQNGYHGIVMNNF--ECEPA---FYTCVEVTAGNRLF 559
R+ I + ++ Y G V C+P + V G +
Sbjct: 484 LGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD 543
Query: 560 YHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVR--DTAYPETNDAIPMISKLRYN- 616
IVDS++ + + E TFLPL+ L+V+ D E A +I +RY
Sbjct: 544 AIIVDSEKTGRDCIQYIKEQRGEPE-TFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEP 602
Query: 617 PRFDKAFKHVFGKTLICRSMEVSTQLARAFTM--DCITLEGDQVSHRGALTGGYYDTR-K 673
P KA ++ G L+C ++E + ++A + L+G G ++GG D + K
Sbjct: 603 PHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAK 662
Query: 674 SRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQ----MQQIETQQRKFK 729
+R +K V K +E+ L +L E ++ +R E+ Q+ +Q +++ Q +
Sbjct: 663 ARRWDEKAVDKLKEKKERLTEELKEQMK--AKRKEAELRQVQSQAHGLQMRLKYSQSDLE 720
Query: 730 ASRDSILSEMKMLKEKRQQSEKTFMPK----QRSLQSLEASLHAMESTRESLKAELGTDL 785
++ L+ K K + F P+ +R +QS E + ++ ++ E+ +
Sbjct: 721 QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF 780
Query: 786 LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLD-QVE 844
++ + + IR+ ++E + NE K R+E EN + RL Q++
Sbjct: 781 CREIGVRN----------IREFEEEKVKRQNEIAK-----KRLEF---ENQKTRLGIQLD 822
Query: 845 QELNELRETEGGTVLTATT-----SELEAINKR-------VKDTMARSEDLDNSIDKTEA 892
E N+L+E + + T +E+E + K + +TMA+ +DL N ++
Sbjct: 823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKS 882
Query: 893 GIKELQKSMERWK------NMEKEHM--DAINHDTKELEKMTNRQGMLLKKKEECMKKIR 944
+ + ME + N E H+ + +TK +K ++R +L K + +K
Sbjct: 883 EVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPL 942
Query: 945 ELGSLPQEAFEK-----YQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQFVNFSEQKE 998
G++ + E+ ++S Q + ++ Y + + D E K+
Sbjct: 943 SKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-EEIKQ 1001
Query: 999 KLIKRQEELDRGYKSIMELM--NVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLV 1056
++ Q++L+ + + N+ + K E+++ F++ S F ++ +A
Sbjct: 1002 EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQ 1061
Query: 1057 MKKGDVEGSQSQDEGEGSGESE------RGSGSQSSV----PSVDQFTGVGIRVSFTGKQ 1106
+KK + + E + E R S +Q+ + P G+ GK+
Sbjct: 1062 IKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKR 1121
Query: 1107 GEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAV 1166
R M LSGG+K++ ALAL+FAI PAPF++ DEID ALD + V++ I E +
Sbjct: 1122 --FRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQST 1179
Query: 1167 -HAQFITTTFRPELLESADKFYGV 1189
+ Q I + + E A+ GV
Sbjct: 1180 CNFQAIVISLKEEFYTKAESLIGV 1203
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
sapiens]
Length = 1235
Score = 192 bits (488), Expect = 2e-48
Identities = 278/1288 (21%), Positives = 534/1288 (41%), Gaps = 191/1288 (14%)
Query: 2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQR 61
+++ ++++ F+S+R + ++ PF + I+G NGSGKSN A+ FV+ ++ ++LR +
Sbjct: 3 HLELLLVENFKSWRGRQVIGPFR-RFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNI 61
Query: 62 LALLHEGTGPRVIS--AFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKN 119
L+H + IS A V+II+ EE + R+I ++ + +V+++
Sbjct: 62 QELIHGAHIGKPISSSASVKIIYVEESG------EEKTFARIIRGGCSEFRFNDNLVSRS 115
Query: 120 DVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGT-RVYDERKEESISL 178
+ LE G +V QG + ++ +R + E++ + + E +E+ L
Sbjct: 116 VYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKL 175
Query: 179 MKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ------KWDKMRRALEYTIYNQE- 231
K E + N+ ER + EKEE +YQ K +K++ L +N++
Sbjct: 176 QKAEEDAQFNFNKKKNIAAERRQA-KLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKK 234
Query: 232 LNETRAKLD----ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEE 287
++ KL+ +LS KRE+ ++ +++ +++ +ELK+ + + ++
Sbjct: 235 IHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQK 294
Query: 288 KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQR---KRLLKE-----------RQKL 333
+ Q ++ KL++ K ++D S+Q K L E +++
Sbjct: 295 RPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQI 354
Query: 334 LEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK 393
E+I K++++ + + KE +E+ ++A TQ+ L +Q + + E+R
Sbjct: 355 EEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRH 414
Query: 394 W-IKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQD-LNEVKARVEEL 451
++ LK + + I D K++I + LE+Y K D L E K + E L
Sbjct: 415 GEVQGNLKQIKEQIEDHKKRI---------------EKLEEYTKTCMDCLKEKKQQEETL 459
Query: 452 DRKYYEVKNKKDELQSERNYLWRE-ENAEQQALAAKREDLEKKQQLLRAATGKAILNGID 510
+ + K++ E E N + E +NA KR+
Sbjct: 460 VDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQ--------------------- 498
Query: 511 SINKVLDHFRRKGINQHVQNGYHGIVMNNFE--CEPAF--YTCVEVTAGNRLFYHIVDSD 566
+R + +H++ Y V C P Y R IV +
Sbjct: 499 ---------KRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVAS 549
Query: 567 EVSTKILMEFNKMNLPGEVTFLPLNKLDVR--DTAYPETNDAIPMISKLRYN-PRFDKAF 623
E K + F K TFL L+ LD++ + E +I ++ P+ K
Sbjct: 550 EKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVI 609
Query: 624 KHVFGKTLICRSMEVSTQLARA--FTMDCITLEGDQVSHRGALTGGYYDTR-KSRLELQK 680
+ V G L+C +ME + +A + + L+G G ++GG D + K+R +K
Sbjct: 610 QFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEK 669
Query: 681 DVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ-IETQQRKFKASRDSILSEM 739
+++ + + K+ E L+ ++ + E D + Q+Q I+ Q + K S+ +E+
Sbjct: 670 ELKNLRDRRSQ---KIQE-LKGLMKTLRKETD--LKQIQTLIQGTQTRLKYSQ----NEL 719
Query: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
+M+K+K + F +Q LQS E L E +LS+ E Q+R+
Sbjct: 720 EMIKKKHLVA---FYQEQSQLQS------------ELLNIESQCIMLSEGIKERQRRIKE 764
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
++I +++ + Q E I +E I + N+++ KR +++Q+ E + +
Sbjct: 765 FQEKIDKVEDDIFQHFCEEIGVENI----REFENKHV-KRQQEIDQKRLEFEKQK----- 814
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDT 919
T +LE +K + + L +I K I L+K+ E E M A
Sbjct: 815 TRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELM-AKQQQL 873
Query: 920 KELEKMTNR-----QGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNT 974
K++ N Q + +++++ + RE+G L +E +L K+L + +
Sbjct: 874 KDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDC 933
Query: 975 ELKKYSHV-NKKALDQFVNFSEQKE--------KLIKRQEELDRGYKSIMELMNVLEL-R 1024
+++ + +LD + E + +++E + Y S+ E + L+ +
Sbjct: 934 KVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQ 993
Query: 1025 KYEA-IQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESE----- 1078
+ EA ++L +QV+ + + P +A +K + +S D E S +
Sbjct: 994 EIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQ 1053
Query: 1079 --------------------------------RGSGSQSSV----PSVDQFTGVGIRVSF 1102
R + +Q+ + P G+
Sbjct: 1054 EFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPENPEEPYLEGISYNCVA 1113
Query: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
GK+ M LSGG+K + ALAL+FA+ PAPF++ DE+D ALD + VS I
Sbjct: 1114 PGKR--FMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIK 1171
Query: 1163 ELAV-HAQFITTTFRPELLESADKFYGV 1189
E Q I + + E AD G+
Sbjct: 1172 EQTQDQFQMIVISLKEEFYSRADALIGI 1199
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 120 bits (301), Expect = 8e-27
Identities = 176/894 (19%), Positives = 373/894 (41%), Gaps = 84/894 (9%)
Query: 154 QRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLK-YIEERLHTLEEEKEELAQ 212
Q+L+L + A ++ ++ EE I L+++ K K +L++ I E L EE+E+
Sbjct: 967 QKLQLEKVTAEAKI--KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 213 YQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIER 272
K + + + + E + + + AKR+ GE + D +D++ +++
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT--------DLQDQIAELQA 1076
Query: 273 QVRELKTKISAMKEEKEQLSAERQEQ-------IKQRTKLELKAKDLQDELAGNSEQRKR 325
Q+ ELK +++ +EE + A ++ +K +L+ + +LQ++ R +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKE---KEERGIARLAQATQERTDLYAKQGRG 382
K+++ L E++E + EL +T + +E K E+ +A L +A +E T + Q +
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 383 ---------SQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQ 433
+ + + E+ K K L+ Q + +++A K L+ +A E +
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE---HK 1253
Query: 434 YNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSER-NYLWREENAEQQAL------AAK 486
KLD + E+ A+V E DR E+ K +LQ+E N E AE++ + A+
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 487 REDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAF 546
L+ Q+LL+ T + + +++ + + + Q N E +
Sbjct: 1314 ESQLQDTQELLQEETRQKL-----NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 547 YTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDA 606
++ D++ T +E K L + L +L+ + AY +
Sbjct: 1369 LQSQLADTKKKV------DDDLGTIESLEEAKKKLLKDAEALS-QRLEEKALAYDKLEK- 1420
Query: 607 IPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTG 666
+K R D + + + ++E + + ++ R
Sbjct: 1421 ----TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 667 GYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQR 726
+ L L + + +A E E E + N+ LR ++E + + D + + ++E +R
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQ-NKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 727 KFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLL 786
+ + + ++++ L+++ Q +E + + ++Q+++A TR+ E L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 787 SQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQE 846
K+V L E+ +++ + + K+E + +E + E K D+V ++
Sbjct: 1596 --------KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQ 1646
Query: 847 LNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQK---SMER 903
L +L+ + ELE + A+S++ + + EA I +LQ+ S ER
Sbjct: 1647 LRKLQAQ-----MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 904 WKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLK 963
+ ++ D + E+ + + LL +K +I +L +E E+ L
Sbjct: 1702 ARRHAEQERDEL---ADEITNSASGKSALLDEKRRLEARIAQLEEELEE--EQSNMELLN 1756
Query: 964 QLFRK----LEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKS 1013
FRK ++ N EL +K+ + Q ++L + +EL+ KS
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Score = 117 bits (293), Expect = 7e-26
Identities = 179/838 (21%), Positives = 356/838 (42%), Gaps = 118/838 (14%)
Query: 149 TAPDSQRLKLLREVAG--TRVYDERKEESISLMKETEGKR---EKINELLKYIEERLHTL 203
T + LK++RE+ + ++ + E S K + KR E++ L +E+ L T
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 204 EEEKE-ELAQYQKWDKMRRALEYTIYNQE--LNETRAK----LDELSAKRETSGEKSRQL 256
++E + Q+ ++++ALE N E + + R + L+ELS + E + L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 257 RDAQQDARDKMEDIERQVRELKTKISAMKEEK--------EQLSAERQEQIKQRTKLELK 308
+Q +++ +V+ L+ ++ A E K ++L A+ E + R +L K
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQ-QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Query: 309 AKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQA 368
A LQ+EL S + K+ K + + +L +T+ ++ +R+ Q
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 369 TQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE 428
+E+ L +Q +EE K ++K++ +L + D K+++ +E E K+
Sbjct: 1342 EEEKNSLQEQQ------EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 429 KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNY-------LWREENAEQQ 481
K L+ L Q L E ++L++ ++ + D+L + ++ L +++ Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 482 ALAAKR-------EDLEKKQQLLRAATGKAI--LNGIDSINKVLDHFRRKGINQHVQNGY 532
LA ++ E+ ++ + R KA+ ++ + + F R+ N+ ++
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ--NKQLRADM 1513
Query: 533 HGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKIL-MEFNKMNLPGEVTFLPLN 591
++ + D+V + +E +K L +V +
Sbjct: 1514 EDLMSSK--------------------------DDVGKNVHELEKSKRALEQQVEEMR-T 1546
Query: 592 KLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCI 651
+L+ + T DA KLR +A K F + L R E + + R
Sbjct: 1547 QLEELEDELQATEDA-----KLRLEVNM-QAMKAQFERDLQTRD-EQNEEKKRLLIKQVR 1599
Query: 652 TLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEI 711
LE + D RK R +K E +L +LEA++ E + + + ++
Sbjct: 1600 ELEAE-----------LEDERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQL 1647
Query: 712 DQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAME 771
+L QM+ + + + +ASRD I ++ K ++K + E + Q L S E + E
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 772 STRESLKAELGTDLLSQLSLEDQK-----RVDALNDEIRQLQQENRQLLNER-------- 818
R+ L E+ + +L D+K R+ L +E+ + +Q N +LLN+R
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE-EQSNMELLNDRFRKTTLQV 1766
Query: 819 --IKLEGIITRVETYLNENLRKRLDQVEQELN-ELRETEGG--TVLTATTSELEA----I 869
+ E R ++N R++L++ +EL +L+E EG + AT S LEA +
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 870 NKRVKDTMARSEDLDNSIDKTEAGIKELQKSME---RWKNMEKEHMDAINHDTKELEK 924
++++ + + +TE +KE+ +E R + KE M+ N K+L++
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884
Score = 112 bits (280), Expect = 2e-24
Identities = 184/949 (19%), Positives = 392/949 (41%), Gaps = 134/949 (14%)
Query: 165 TRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALE 224
TR +E + + L+K E K+ K+ L+ +E + L EEK LA+ + +
Sbjct: 848 TRQEEELQAKDEELLKVKE-KQTKVEGELEEMERKHQQLLEEKNILAEQLQAE------- 899
Query: 225 YTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAM 284
T E E RA+L +AK++ E L ++ ++ + ++ + ++++ I +
Sbjct: 900 -TELFAEAEEMRARL---AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 285 KEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKEL 344
+E+ ++ RQ+ ++ E K K +++E+ +Q + +KE++ + ++I E +L
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 345 AETEPKFNS---VKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKS 401
AE E K + ++ K+E I+ L + ++ + + + E D ++ ++
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD--LQDQIAE 1073
Query: 402 LDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNK 461
L I++ K Q+A ++L+ A + N + + E++A++ EL + K
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 462 KDELQSERNYLWREENAEQQAL------AAKREDLEKKQQLLRAATGKAI---------- 505
+++ + ++ L E A + L A +++L K++ A KA+
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 506 --------LNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFE--CEPAFYTCV----- 550
++ +++ L+ +R +++ G+ +N E CE V
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKR--FKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 551 ---------------EVTAGNRLFYHIVDS--------DEVSTKILMEFNK--MNLPGEV 585
+V+ G+RL + + D VST +L E K + +
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST-LLEEAEKKGIKFAKDA 1310
Query: 586 TFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARA 645
L D ++ ET + + S++R K + E + +
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEE---------EKNSLQEQQEEEEEARKN 1361
Query: 646 FTMDCITLEGDQVSHRGAL---TGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRR 702
+ L+ + + G +++ +L KD + L E +A + L +
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE-KALAYDKLEK 1420
Query: 703 NIERINNEIDQL---MNQMQQIETQQRKFKASRDSILSEMKMLK----EKRQQSEKTFMP 755
R+ E+D L ++ +Q+ + K + D +L+E K + E+R ++E
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 756 KQRSLQSLEASL-HAMESTRE------SLKAELGTDLLSQL--------SLEDQKR---- 796
K+ SL +L A+E+ E L+A++ DL+S LE KR
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADM-EDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 797 -VDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQE----LNELR 851
V+ + ++ +L+ E + + +++LE + ++ +L+ R +Q E++ + ++R
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
E E +ELE K+ +A + ++ + EA I+ K+ + ++
Sbjct: 1600 ELE---------AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL-SLKQLFRKLE 970
+ +ELE+ + + + +E KK++ SL E + + L S ++ R E
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLK---SLEAEILQLQEELASSERARRHAE 1707
Query: 971 QCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMN 1019
Q EL + ++ + E I + EE +S MEL+N
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Score = 108 bits (270), Expect = 3e-23
Identities = 215/992 (21%), Positives = 400/992 (40%), Gaps = 194/992 (19%)
Query: 152 DSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEE-KEEL 210
+ Q K ++E ++ ++R E S + E E K + + ++ E + LEE K+E
Sbjct: 991 EDQNSKFIKE---KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 211 AQYQKWDKMRRAL--EYTIYNQELNETRAKLDELS---AKRETSGEKS------------ 253
Q+ +K +R L E T ++ E +A++DEL AK+E + +
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 254 ---RQLRDAQQDARDKMEDIE----------RQVRELKTKISAMKEE------------- 287
+ +R+ Q + ED E +Q R+L ++ A+K E
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 288 ----KEQLSAERQEQIKQRTK-LELKAKDLQ-------DELAGNSEQRKRLLKERQKLLE 335
+EQ AE ++ +++ TK E + +D++ +EL+ EQ KR +K +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 336 KIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWI 395
+E KELA VK + E +L QE L+AK G + +
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE---LHAKVSEGDR----------L 1274
Query: 396 KKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKY 455
+ EL + ++ ++ + LE+ E K + L+ L + + ++E R+
Sbjct: 1275 RVELAEKASKLQNELDNVSTL---LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 456 YEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLR---AATGKAILNGIDSI 512
+ ++ +L+ E+N L ++ E++A R++LEK+ L+ A T K + + + +I
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEA----RKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 513 NKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHI----VDSD-- 566
L+ ++K + + E + Y +E T NRL + VD D
Sbjct: 1388 ES-LEEAKKKLLKD------AEALSQRLEEKALAYDKLEKTK-NRLQQELDDLTVDLDHQ 1439
Query: 567 -EVSTKILMEFNKMN-LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFK 624
+V++ + + K + L E + + RD A E + + KA
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE------------KETKALS 1487
Query: 625 HVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRK 684
+ R++E + + F L D L D K+ EL+K R
Sbjct: 1488 -------LARALEEALEAKEEFERQNKQLRADMED----LMSSKDDVGKNVHELEKSKRA 1536
Query: 685 AEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKM--- 741
E+++ E+ +L E L ++ + +L MQ ++ Q + +RD E K
Sbjct: 1537 LEQQVEEMRTQL-EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 742 ---------LKEKRQQSEKTFMPKQR---SLQSLEASLHAMESTRESL------------ 777
L+++R+Q K++ L+ LEA + A R+ +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 778 -------KAELGTDLLSQLSLEDQKRVDALNDEIRQLQQE-------NRQLLNERIKLEG 823
+A D + S E +K++ +L EI QLQ+E R ER +L
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 824 IITR----VETYLNE--NLRKRLDQVEQELNELRETEGGTVLT----ATTSELEAINKRV 873
IT L+E L R+ Q+E+EL E E +L TT +++ +N +
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEE--EQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 874 KDTMARSEDLDNSIDKTEAGIKELQKSMERW----KNMEKEHMDAINHDTKELEKMTNRQ 929
+ ++ DN+ + E KEL+ ++ K+ K + A+ +LE+ ++
Sbjct: 1774 AAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Query: 930 -------GMLLKKKEECMKKI-------RELGSLPQEAFEKYQTLSLKQLFRKLEQCNTE 975
L+++ E+ +K+I R +E EK +KQL R+LE+ E
Sbjct: 1834 AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK-ANARMKQLKRQLEEAEEE 1892
Query: 976 LKKYSHVNKKALDQFVNFSEQKEKLIKRQEEL 1007
+ + +K + + +E E L + L
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Score = 93.2 bits (230), Expect = 1e-18
Identities = 197/978 (20%), Positives = 397/978 (40%), Gaps = 142/978 (14%)
Query: 209 ELAQYQKW---DKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARD 265
+L +Q W K++ L+ T +EL +AK +EL +E
Sbjct: 828 KLRHWQWWRVFTKVKPLLQVTRQEEEL---QAKDEELLKVKE------------------ 866
Query: 266 KMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
K +E ++ E++ K + EEK L+ EQ++ T+L +A++++ LA ++ +
Sbjct: 867 KQTKVEGELEEMERKHQQLLEEKNILA----EQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 326 LLKERQKLLEKIEEK----QKELAETEPKFNSVKEK--EERGIARLAQATQERTDLYAKQ 379
+L + + +E+ EE+ Q E + + ++E+ EE G + Q + + K+
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 380 GRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQY-NKLD 438
+++ K+I KE K ++ I + Q+A E K KNL + NK +
Sbjct: 983 MEEEILLLEDQNSKFI-KEKKLMEDRIAECSSQLA--------EEEEKAKNLAKIRNKQE 1033
Query: 439 QDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQA--------LAAKREDL 490
+++++ R+++ ++ E++ K +L E L +++ AE QA LA K E+L
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKRKLDGETTDL-QDQIAELQAQIDELKLQLAKKEEEL 1092
Query: 491 E------KKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFEC-E 543
+ + L + K + I ++ + F + +++ + E +
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 544 PAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRD---TAY 600
++ TA + + + K +E N ++ D+R TA
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ-------DMRQRHATAL 1205
Query: 601 PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQL------------ARAFTM 648
E ++ + + + N +K K L C ++V Q+ A+ +
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELAC-EVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 649 DCITLEGD----QVSHRGALTGGYYDTRKSRLE--------LQKDVRKAEEELGELEAKL 696
EGD +++ + + D + LE KD E +L + + L
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL 1324
Query: 697 NENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPK 756
E R+ + +++ I QL + ++ QQ + + +R ++ ++ L+ + ++K
Sbjct: 1325 QEETRQKL-NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 757 QRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLED-----QKRVDALNDEIRQLQQEN 811
+++SLE + + E+L L L+ LE Q+ +D L ++ +Q
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443
Query: 812 RQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEA--- 868
L ++ K + ++ E ++ + D+ E E E +ET+ ++ A LEA
Sbjct: 1444 SNLEKKQKKFDQLLAE-EKSISARYAEERDRAEAEARE-KETKALSLARALEEALEAKEE 1501
Query: 869 INKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELE---KM 925
++ K A EDL +S D + EL+KS K ++ ++ + +ELE +
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKS----KRALEQQVEEMRTQLEELEDELQA 1557
Query: 926 TNRQGMLLKKKEECMKK--IRELGSLPQEAFEKYQTL--SLKQLFRKLEQCNTELKKYSH 981
T + L+ + MK R+L + ++ EK + L +++L +LE +
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 982 VNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEA----IQLTFKQVS 1037
KK + Q E K ++E+ + +LRK +A Q ++
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEV------------IKQLRKLQAQMKDYQRELEEAR 1665
Query: 1038 KNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVG 1097
+ E+F + K +K + E Q Q+E S E R Q D+ T
Sbjct: 1666 ASRDEIFAQSKESEKK---LKSLEAEILQLQEE-LASSERARRHAEQERDELADEITN-- 1719
Query: 1098 IRVSFTGKQGEMREMQQL 1115
S +GK + E ++L
Sbjct: 1720 ---SASGKSALLDEKRRL 1734
Score = 82.4 bits (202), Expect = 2e-15
Identities = 92/413 (22%), Positives = 188/413 (45%), Gaps = 45/413 (10%)
Query: 112 DKKMVTKNDVMNLLESAGFSRSNPYYIV-----KQGKINQMATAPDSQRLKLLREVAGTR 166
DK TKN + L+ + + KQ K +Q+ S + E
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 167 VYDERKE-ESISL---MKETEGKREKINELLKYIEERLHTLEEEKEELAQ-YQKWDKMRR 221
KE +++SL ++E +E+ K + + L K+++ + + +K +R
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 222 ALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME-DIERQVRELKTK 280
ALE Q++ E R +L+EL + + + + +L Q + + E D++ + + + K
Sbjct: 1536 ALE-----QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 281 ISAMKEEKEQLSAERQEQIKQRT-------KLELKAKDLQDELAGNSEQRKRLLKERQKL 333
+ ++ +L AE +++ KQR K+E+ KDL+ ++ ++ R ++K+ +KL
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 334 LEKIEEKQKELAETEPK----FNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKE 389
++++ Q+EL E F KE E++ + A+ Q + +L + + ++ +++
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE--RARRHAEQ 1708
Query: 390 ERDKWIKKELKSLD--QAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKAR 447
ERD+ + S A+ D+KR++ A LE+ ++ N+E N
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN------------ 1756
Query: 448 VEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAA 500
+ + +V EL +ER+ + +NA QQ L + ++L+ K Q L A
Sbjct: 1757 -DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ-LERQNKELKAKLQELEGA 1807
Score = 68.9 bits (167), Expect = 3e-11
Identities = 80/411 (19%), Positives = 184/411 (44%), Gaps = 61/411 (14%)
Query: 141 QGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERL 200
Q +++ ++T + K ++ + + +++ L++E ++ ++ ++ +EE
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 201 HTLEEEKEELAQYQK-WDKMRRALEYTIYNQELNETRAKL-DELSAKRETSGEKSRQLRD 258
++L+E++EE + +K +K AL+ +L +T+ K+ D+L K + L+D
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQ-----SQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 259 A------------------------QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAE 294
A QQ+ D D++ Q R++ + + +++ +QL AE
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ-RQVASNLEKKQKKFDQLLAE 1459
Query: 295 RQ---------------EQIKQRTKLELKAKDLQDELAGNSE---QRKRLLKERQKLLEK 336
+ E ++ TK A+ L++ L E Q K+L + + L+
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 337 IEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF-TSKEERDKWI 395
++ K + E E +++++ E +L + E L A + + + +
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE---LQATEDAKLRLEVNMQAMKAQF 1576
Query: 396 KKELKSLDQAINDKKR----QIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEEL 451
+++L++ D+ +KKR Q+ + +LED + + K++ DL +++A++E
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 452 DRKYYEVKNKKDELQSERNYLWR---EENAEQQALAAKREDLEKKQQLLRA 499
++ EV + +LQ++ R E A + + A+ ++ EKK + L A
Sbjct: 1637 NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687
Score = 60.1 bits (144), Expect = 1e-08
Identities = 139/719 (19%), Positives = 287/719 (39%), Gaps = 98/719 (13%)
Query: 341 QKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELK 400
+K A+ + + +++K + A L + ++ K Q T +EE EL+
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEE-------ELQ 855
Query: 401 SLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDL----------NEVKARV-- 448
+ D+ + K + + +LE+ E ++ LE+ N L + L E++AR+
Sbjct: 856 AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAA 915
Query: 449 --EELDRKYYEVKNKKDELQSERNYLWREENAEQQA-LAAKREDLEK----KQQL-LRAA 500
+EL+ ++++++ +E + ERN + + E + QA + E L++ +Q+L L
Sbjct: 916 KKQELEEILHDLESRVEE-EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
T +A + ++ +L+ K I + +M + E + E L
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKK-------LMEDRIAECSSQLAEEEEKAKNL-A 1026
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
I + EV L E K E T L K + ET D I++L+ + D
Sbjct: 1027 KIRNKQEVMISDLEERLKKE---EKTRQELEK--AKRKLDGETTDLQDQIAELQ--AQID 1079
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQK 680
+ L + E+ LAR D+ H+ + + ELQ+
Sbjct: 1080 E-----LKLQLAKKEEELQGALARG---------DDETLHKNNALKVVRELQAQIAELQE 1125
Query: 681 DVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMK 740
D + + E K +L +E + E++ ++ Q++ + R+ ++E+K
Sbjct: 1126 DFESEKASRNKAE-KQKRDLSEELEALKTELEDTLD----TTAAQQELRTKREQEVAELK 1180
Query: 741 MLKEKRQQSEKTFMP--KQRSLQSLEASLHAMESTR------ESLKAELGTD-------- 784
E+ ++ + + +QR +LE +E + E K L TD
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 785 -LLSQLSLEDQKRVDALNDEIRQLQQE-------NRQLLNERIKLEGIITRVETYLNENL 836
+L Q+ E + + L+ ++++L + +L + KL+ + V T L E
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 837 RKRLD------QVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKT 890
+K + +E +L + +E +L T + ++ R++ L ++
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQE-----LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 891 EAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLP 950
E K L+K + ++ + ++ D +E + + LLK E +++ E +L
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE-KALA 1414
Query: 951 QEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDR 1009
+ EK + ++L + + + S++ KK +E+K + EE DR
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Score = 44.7 bits (104), Expect = 5e-04
Identities = 61/288 (21%), Positives = 122/288 (42%), Gaps = 40/288 (13%)
Query: 111 LDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTR---- 166
L K D LE A SR + K+ + + + +++ L+L E+A +
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESE--KKLKSLEAEILQLQEELASSERARR 1704
Query: 167 -VYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW--DKMRRA- 222
ER E + + GK ++E + +E R+ LEEE EE + D+ R+
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRR-LEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 223 LEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMED-IERQVRELKTKI 281
L+ N EL R+ + R+ ++++L+ Q+ ++ + + L+ KI
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 282 SAMKEEKEQLSAERQ--EQIKQRTKLELKA---------------KDLQDELAGNSEQRK 324
++E+ EQ + ER ++ +RT+ +LK K+ ++ +Q K
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 325 RLLKE-----------RQKLLEKIEEKQKELAETEPKFNSVKEKEERG 361
R L+E R+KL ++++ + + +++K + RG
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Score = 41.2 bits (95), Expect = 0.006
Identities = 59/256 (23%), Positives = 112/256 (43%), Gaps = 42/256 (16%)
Query: 280 KISAMKEEKEQLSAERQEQIKQRTKLELKAKDL------QDELAGNSEQRKRLLKERQKL 333
++SA+K + +A + + Q ++ K K L ++EL E+ ++ +++ K+
Sbjct: 812 QLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKV 871
Query: 334 ---LEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGR--------G 382
LE++E K ++L E + N + E+ + A+A + R L AK+
Sbjct: 872 EGELEEMERKHQQLLEEK---NILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLE 928
Query: 383 SQFTSKEERDKWIKKELKSLDQAINDKKRQI-----AAIHKDLEDTEAN-KEKNLEQYNK 436
S+ +EER++ ++ E K + I D + Q+ A LE A K K +E+
Sbjct: 929 SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL 988
Query: 437 LDQDLNE--------VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKRE 488
L +D N ++ R+ E + E + K L RN +Q+ + + E
Sbjct: 989 LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN--------KQEVMISDLE 1040
Query: 489 DLEKKQQLLRAATGKA 504
+ KK++ R KA
Sbjct: 1041 ERLKKEEKTRQELEKA 1056
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 119 bits (298), Expect = 2e-26
Identities = 207/1043 (19%), Positives = 429/1043 (41%), Gaps = 153/1043 (14%)
Query: 170 ERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYN 229
ER++E S+ +E ++ E L+ E R LEE+ L Q +K L+
Sbjct: 844 EREKEMASMKEEFT----RLKEALEKSEARRKELEEKMVSLLQ----EKNDLQLQVQAEQ 895
Query: 230 QELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKE 289
L + + D+L + K +++ + +D + ++ + R+L+ + S +K + +
Sbjct: 896 DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEP 349
L + K++ E K K+L +E+AG E +L KE++ L E ++ +L E
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 350 KFNSV---KEKEERGI----ARLAQATQERTDL-YAKQGRGSQFTSKEERDKWIKKELKS 401
K N++ K K E+ + L Q + R DL AK+ +E ++ + +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 402 LDQAINDKKRQIAAIHKDLEDTEA---NKEKNLEQYNKLDQDLNE-------VKARVE-- 449
LD+ + K ++ A++ +ED +A +K L++ ++L E +A+VE
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 450 --ELDRKYYEVKNKKDE------LQSERNYLWREENAEQQALAAKREDLEKKQQLLRAAT 501
+L R+ E+ + +E +Q E N ++ AE Q + E+ + + AA
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMN---KKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 502 GKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAG-NRLFY 560
K + + + + +D+ +R + Q ++ + F+ E +VT+ ++
Sbjct: 1193 RKKHADSVAELGEQIDNLQR--VKQKLEK-----EKSEFKLE-----LDDVTSNMEQIIK 1240
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAI--------PMIS- 611
+ +++ + + N+ E T +N L + N + +IS
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1300
Query: 612 ----KLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGA---- 663
KL Y + + + + + ++ + Q AR DC L A
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEEETEAKAEL 1357
Query: 664 ---LTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIE--------------- 705
L+ + + R + + D + EEL E + KL + L+ E
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 706 --RINNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPK 756
R+ NEI+ LM +++ ++ +QR F D IL+E K+K ++S+
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNF----DKILAEW---KQKYEESQSELESS 1470
Query: 757 QRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQ-----KRVDALNDEIRQLQQEN 811
Q+ +SL L +++ E L T +L+++ +++ + I +L++
Sbjct: 1471 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR 1530
Query: 812 RQLLNERIKL--------------EGIITRVETYLNE---NLRKRLDQVEQELNELRETE 854
+QL E+++L EG I R + N+ + ++L + ++E+ + +
Sbjct: 1531 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1590
Query: 855 GGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIK-------ELQKSMERWKNM 907
V + TS L+A + + + + ++ +++ E + E QK ++ +++
Sbjct: 1591 LRVVDSLQTS-LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1649
Query: 908 EKEHM----DAI--NHDTKELEKMTNRQGMLLKKKEECMKKI-----RELGSLPQEAFEK 956
K+ DA+ N D KE + R+ LL+ + E ++ + R QE E
Sbjct: 1650 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Query: 957 YQTLSL-----KQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGY 1011
+ + L L + ++ + +L + ++A+ + N E+ +K I +
Sbjct: 1710 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 1012 KSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEG 1071
K + LE R + ++ T K + E Q + GGK L + V +++ E
Sbjct: 1770 KKEQDTSAHLE-RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 1072 EGSGESERGSGSQSSVPSVDQFT 1094
E +E G + S + + T
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELT 1851
Score = 107 bits (267), Expect = 7e-23
Identities = 216/999 (21%), Positives = 419/999 (41%), Gaps = 176/999 (17%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEE-------RLHTLEEEKEELAQ--------Y 213
+ER ++ I + E K +++NE L+ EE + LE+E EL +
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 214 QKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQ 273
K +K + A E + N L E A LDE+ AK ++ + L++A Q A D ++ E +
Sbjct: 962 AKVEKEKHATENKVKN--LTEEMAGLDEIIAKLT---KEKKALQEAHQQALDDLQAEEDK 1016
Query: 274 VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
V L ++++ + L +++ K R LE + L+ +L E L ++Q+L
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Query: 334 LEKIEEK---------------------QKELAETEPKFNSVKEKEERGIARLAQATQER 372
E++++K QK+L E + + ++E+ E A+ + R
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Query: 373 TDL------------YAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHK-- 418
+DL A Q ++R+ +K + L++A + AA+ K
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196
Query: 419 ------------------------------DLEDTEANKEK------NLEQY-NKLDQDL 441
+L+D +N E+ NLE+ L+ +
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAA-----------KREDL 490
NE +++ EE R ++ +++ +LQ+E L R+ + E++AL + + EDL
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD-EKEALISQLTRGKLTYTQQLEDL 1315
Query: 491 EKKQQLLRAATGK-AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTC 549
K+QL K A+ + + S D R + + V++ E A +
Sbjct: 1316 --KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1373
Query: 550 VEVT-----------AGNRLFYHIVDSDEVSTKI-----LMEFNKMNLPGEVTFLPLNKL 593
T A +L + +++E + +E K L E+ L +
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MV 1430
Query: 594 DVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRS-MEVSTQLARAFTMDCIT 652
DV +N A + K + N FDK K +S +E S + AR+ + +
Sbjct: 1431 DVE-----RSNAAAAALDKKQRN--FDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1483
Query: 653 LEG---DQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLN--ENLRRNIERI 707
L+ + + H ++ LQ+++ E+LG ++ E +R+ +E
Sbjct: 1484 LKNAYEESLEHLETF-------KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 708 NNEIDQLMNQMQ-QIETQQRKFKASR---DSILSEM-KMLKEKRQQSEKTFMPKQRSLQS 762
E+ + + + +E ++ K ++ + I +E+ + L EK ++ E+ R + S
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 763 LEASLHAMESTRES---LKAELGTDLLS-QLSLEDQKRVDALNDEIRQLQQENRQLLNER 818
L+ SL A +R +K ++ DL ++ L R+ A + +Q++ L + +
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA--EAQKQVKSLQSLLKDTQ 1654
Query: 819 IKLEGIITRVETYLNENL---RKRLDQVEQELNELRETEGGTVLTATTSELEAI--NKRV 873
I+L+ + R L EN+ +R + ++ EL ELR T + +E E I ++RV
Sbjct: 1655 IQLDDAV-RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713
Query: 874 KDTMARSEDLDNSIDKTEAGIKELQ----KSMERWKNMEKEHMDAINHD---TKELEKMT 926
+ +++ L N K +A + +LQ ++++ +N E++ AI +EL+K
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773
Query: 927 NRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKA 986
+ L + K+ + I++L EA E+ K+ +KLE EL+ +K
Sbjct: 1774 DTSAHLERMKKNMEQTIKDLQHRLDEA-EQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 987 LDQFVNFSEQKEKLIKR---QEELDRGYKSIMELMNVLE 1022
+ V + E+ IK Q E DR K+++ L ++++
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEEDR--KNLLRLQDLVD 1869
Score = 86.3 bits (212), Expect = 2e-16
Identities = 196/976 (20%), Positives = 382/976 (39%), Gaps = 205/976 (21%)
Query: 266 KMEDIERQVRELKTKISAMKEEKEQLSAERQE-------QIKQRTKLELKAKDLQDELAG 318
K + E+++ +K + + +KE E+ A R+E ++++ L+L+ + QD LA
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 319 NSEQRKRLLKERQKLLEKIEEKQKELAETE---PKFNSVKEKEERGIARLAQATQERTDL 375
E+ +L+K + +L K++E + L + E + + K K E + L + +
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQAI----NDKKRQIAAIHKDLEDTEANKEK-- 429
AK + T E + K + +E+ LD+ I +KK A + L+D +A ++K
Sbjct: 961 LAKVEKEKHAT--ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018
Query: 430 ------------------NLEQYNKLDQDLNEVKARVEE----LDRKYYEVKNKKDELQS 467
+LEQ K+ DL K ++E +++N K +L
Sbjct: 1019 TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Query: 468 ERNYLWREENAEQQALAAKRED-------LEKKQQLLRAATGKAILNGIDSINKVLDHFR 520
++++ E AL A+ ED L+KK + L+A I+ + + L+ R
Sbjct: 1079 R----LKKKDFELNALNARIEDEQALGSQLQKKLKELQAR--------IEELEEELEAER 1126
Query: 521 ---------RKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTK 571
R +++ ++ + E E T V++ + + K
Sbjct: 1127 TARAKVEKLRSDLSRELEE-----ISERLE-EAGGATSVQIEMNKK-------REAEFQK 1173
Query: 572 ILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKA-FKHVFGKT 630
+ + + L E T L K A E + I + +++ +K+ FK
Sbjct: 1174 MRRDLEEATLQHEATAAALRKKHADSVA--ELGEQIDNLQRVKQKLEKEKSEFKLELDD- 1230
Query: 631 LICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELG 690
+ +ME + C TLE HR +T++S +L K + E G
Sbjct: 1231 -VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE----ETQRSVNDLTSQRAKLQTENG 1285
Query: 691 ELEAKLN--------------------ENLRRNIER--------------INNEIDQLMN 716
EL +L+ E+L+R +E ++ D L
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE 1345
Query: 717 QMQQ----------------IETQQRKFKASRDSI-----LSE-MKMLKEKRQQSEKTFM 754
Q ++ E Q + K D+I L E K L ++ Q++E+
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 755 PKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKR------------VDALND 802
SLE + H +++ E L ++ + +L+ ++R +
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 803 EIRQLQQENRQLLNERIKL----EGIITRVETYLNENLRKRLDQVEQELNELRETEGGTV 858
E+ Q+E R L E KL E + +ET+ EN +++E+++L E G +
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN-----KNLQEEISDLTEQLGSS- 1519
Query: 859 LTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHD 918
T ELE + K+++ A +L +++++ EA ++ + + R +E N
Sbjct: 1520 -GKTIHELEKVRKQLE---AEKMELQSALEEAEASLEHEEGKILR-AQLE------FNQI 1568
Query: 919 TKELE-KMTNRQGMLLKKKEECMKKIREL-GSLPQEAFEKYQTLSLKQLFRKLEQCNTEL 976
E+E K+ + + + K ++ + L SL E + + L +K +K+E E+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 977 K-KYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYK---------SIMELMNVLELRKY 1026
+ + SH N+ A + + L Q +LD + +I+E N L +
Sbjct: 1626 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1685
Query: 1027 EAIQLTFKQVSKNFSEVFQKLVPGGKATLVM-----------KKGDVEGSQSQDEGEGSG 1075
E ++ +Q ++ Q+L+ + ++ KK D + SQ Q E E +
Sbjct: 1686 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1745
Query: 1076 ESERGSGSQSSVPSVD 1091
+ R + ++ D
Sbjct: 1746 QECRNAEEKAKKAITD 1761
Score = 77.8 bits (190), Expect = 6e-14
Identities = 71/338 (21%), Positives = 149/338 (44%), Gaps = 20/338 (5%)
Query: 168 YDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTI 227
Y+E + E S KE ++ +L EE L LE K E Q+ E +
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE--------EISD 1511
Query: 228 YNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEE 287
++L + + EL R+ + +L+ A ++A +E E ++ + + + +K E
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Query: 288 KEQLSAERQEQIKQRTKLELKAKD-LQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAE 346
E+ AE+ E+++Q + L+ D LQ L + R L+ ++K+ + E + +L+
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Query: 347 TEPKFNSVKEKEERGIARLAQATQERTD--LYAKQGRGSQFTSKEERDKWIKKELKSLDQ 404
+ + +K+ + + L + TQ + D + A E R+ ++ EL+ L
Sbjct: 1632 AN-RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 405 AINDKKRQIAAIHKDLEDTE-------ANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE 457
+ +R ++L +T + + Q K+D DL++++ VEE ++
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 458 VKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQ 495
+ K + ++ + EE ++Q +A E ++K +
Sbjct: 1751 AEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNME 1787
Score = 77.4 bits (189), Expect = 8e-14
Identities = 159/885 (17%), Positives = 363/885 (41%), Gaps = 146/885 (16%)
Query: 153 SQRLKLLREVAGTRVYDERKEESISLMKETEGKREKI-NELLKYIEERLHTLEEEKEELA 211
SQ K L+E+ R+ E EE + + K EK+ ++L + +EE LEE +
Sbjct: 1102 SQLQKKLKELQA-RI--EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1158
Query: 212 QYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLR-DAQQDARDKMEDI 270
+ +K R A E + R L+E + + E + R+ D+ + ++++++
Sbjct: 1159 VQIEMNKKREA--------EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 271 ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGN----------- 319
+R ++L+ + S K E + +++ ++ IK + LE + L+D++ +
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 320 ---SEQRKRLLKERQKLLEKIEEKQKELAE-TEPKFNSVKEKEE------------RGIA 363
+ QR +L E +L +++EK+ +++ T K ++ E+ +A
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 364 RLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDT 423
Q+ + DL +Q + +K E + + K + Q K + AI + E+
Sbjct: 1331 HALQSARHDCDLLREQYE-EETEAKAELQRVLSKANSEVAQWRT--KYETDAIQRT-EEL 1386
Query: 424 EANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDEL---------------QSE 468
E K+K ++ + ++ + V A+ L++ + ++N+ ++L + +
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 469 RNY-----LWREENAEQQALAAKREDLEKKQQLLRAATGKA--ILNGIDSINKVLDHFRR 521
RN+ W+++ E Q+ +LE Q+ R+ + + + N + + L+ F+R
Sbjct: 1447 RNFDKILAEWKQKYEESQS------ELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500
Query: 522 --KGINQHV-----QNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKIL- 573
K + + + Q G G ++ E ++ + L + KIL
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 1560
Query: 574 --MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTL 631
+EFN++ E KL +D + +K + D + +T
Sbjct: 1561 AQLEFNQIKAEIE------RKLAEKDEEMEQ--------AKRNHLRVVDSLQTSLDAET- 1605
Query: 632 ICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGE 691
RS + ++ + D +E Q+SH + E QK V+ + L +
Sbjct: 1606 --RSRNEALRVKKKMEGDLNEME-IQLSHANRMAA----------EAQKQVKSLQSLLKD 1652
Query: 692 LEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEK 751
+ +L++ +R N D L + +E + +A + + + ++ + R+ +E+
Sbjct: 1653 TQIQLDDAVRAN--------DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Query: 752 TFMPKQRSLQSLEASLHAMESTRESLKAELGT------DLLSQLSLEDQKRVDALND--- 802
+ +Q L + ++ + ++ + A+L + + + ++K A+ D
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAM 1764
Query: 803 ---EIRQLQQENRQLLNERIKLEGIITRVETYLNE-------NLRKRLDQVEQELNELR- 851
E+++ Q + L + +E I ++ L+E +K+L ++E + EL
Sbjct: 1765 MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 1824
Query: 852 ETEGGTVLTATTSE-LEAINKRVKDTMARSED-------LDNSIDKTEAGIKELQKSMER 903
E E A + + + +R+K+ ++E+ L + +DK + +K ++ E
Sbjct: 1825 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Query: 904 WKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGS 948
+ ++ EL++ R + + + K R++G+
Sbjct: 1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGT 1929
Score = 65.9 bits (159), Expect = 2e-10
Identities = 155/806 (19%), Positives = 326/806 (40%), Gaps = 153/806 (18%)
Query: 83 DNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQG 142
+ S+ +L +D ++ ++I AK + L+K T D MN S Q
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKAN---LEKMCRTLEDQMNEHRSKAEET--------QR 1268
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGK---REKINELLKYIEER 199
+N + SQR KL E + KE IS + T GK +++ +L + +EE
Sbjct: 1269 SVNDLT----SQRAKLQTENGELSRQLDEKEALISQL--TRGKLTYTQQLEDLKRQLEEE 1322
Query: 200 L-------HTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEK 252
+ H L+ + + D +R E ET AK + + + E
Sbjct: 1323 VKAKNALAHALQSARHDC------DLLREQYE--------EETEAKAELQRVLSKANSEV 1368
Query: 253 SRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDL 312
++ + DA + E++E ++L ++ +E E ++A+ K + +L+ + +DL
Sbjct: 1369 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Query: 313 QDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQER 372
++ ++ L K+++ + + E +++ E++ + S +KE R ++
Sbjct: 1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES-SQKEARSLS--------- 1478
Query: 373 TDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLE 432
T+L+ + + + E + K+E K+L + I+D Q+ + K + + E +++
Sbjct: 1479 TELFKLK---NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
Query: 433 QYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEK 492
+ +L L E +A +E + K + + +++++E ++ LA K E++E+
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE----------IERKLAEKDEEMEQ 1585
Query: 493 -KQQLLRAATGKAILNGIDSINKVLD-HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCV 550
K+ LR +DS+ LD R + V+ G +N E +
Sbjct: 1586 AKRNHLRV---------VDSLQTSLDAETRSRNEALRVKKKMEG-DLNEMEIQ------- 1628
Query: 551 EVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMI 610
L N+M + L L ++DT + +DA+
Sbjct: 1629 ----------------------LSHANRMAAEAQKQVKSLQSL-LKDTQI-QLDDAVRAN 1664
Query: 611 SKLRYNPRFDKAFKHVFGKTL-----ICRSMEVSTQLARAFTMDCITLEGDQVSHRGALT 665
L+ N + ++ L + E S +LA ++ T E Q+ H
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE--TSERVQLLH----- 1717
Query: 666 GGYYDTRKSRLELQKDVRKAEEELGELEAKLNE------NLRRNIERINNEIDQLMNQMQ 719
++ + L QK +K + +L +L+ ++ E N ++ + + +++
Sbjct: 1718 -----SQNTSLINQK--KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1770
Query: 720 QIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMP-KQRSLQSLEASLHAMESTRES-- 776
+ + + + ++ +K L+ + ++E+ + ++ LQ LEA + +E+ E+
Sbjct: 1771 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQ 1830
Query: 777 ----------LKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIIT 826
K+E L+ + ED+K + L D + +LQ + + +
Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ-------AE 1883
Query: 827 RVETYLNENLRKRLDQVEQELNELRE 852
E N NL K +V+ EL+E E
Sbjct: 1884 EAEEQANTNLSK-FRKVQHELDEAEE 1908
Score = 49.3 bits (116), Expect = 2e-05
Identities = 42/186 (22%), Positives = 89/186 (47%), Gaps = 17/186 (9%)
Query: 332 KLLEKIEEKQKELAETEPKFNSVKEKEERGIAR-------LAQATQERTDLYAK-QGRGS 383
K L K E++KE+A + +F +KE E+ AR + QE+ DL + Q
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 384 QFTSKEER-DKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLN 442
EER D+ IK +++ L+ + + ++ + + A K K ++ ++L +D++
Sbjct: 897 NLADAEERCDQLIKNKIQ-LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 443 EVKARVEELDRKYYEVKNKKDELQSERN-------YLWREENAEQQALAAKREDLEKKQQ 495
+++ + +++++ + +NK L E L +E+ A Q+A +DL+ ++
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 496 LLRAAT 501
+ T
Sbjct: 1016 KVNTLT 1021
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 118 bits (295), Expect = 4e-26
Identities = 197/915 (21%), Positives = 401/915 (43%), Gaps = 152/915 (16%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEE----SISLMKETEGKREKINELLKYIEE 198
K+ +T Q +L ++A ++ +KEE +++ ++E ++ + ++ +E
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 199 RLHTLEEEKE-ELAQYQKWDKMRRAL--EYTIYNQELNETRAKLDELSAKRETSGEKSRQ 255
++ L+E+ E E A K +K +R L E EL +T LD +A++E ++ ++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT---LDSTAAQQELRSKREQE 1168
Query: 256 LRDAQQDARDKMEDIERQVRELKTKIS-AMKEEKEQLSAERQEQI---KQRTKLELKAKD 311
+ ++ ++ + E Q++E++ K S A++E EQL ++ + K + LE + +
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 312 LQDELA------GNSE-QRKRLLKERQKLLEKIEEKQK---ELAETEPKF---------- 351
L +E+ G+SE +RK++ + Q+L K E ++ ELA+ K
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 352 ----NSVKEKEERGIARLAQATQERTDLYAKQGR-----GSQFTSKEERDKWIKKELKSL 402
+S K + + L Q+ +L ++ R ++ E+ +++L+
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Query: 403 DQAINDKKRQIAAIH-------KDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE----- 450
++A ++ ++QIA +H K +ED+ E E KL +DL + R EE
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408
Query: 451 --LDRKYYEVKNKKDEL--------QSERNYLWREEN-----AEQQALAAK-REDLEKKQ 494
L++ ++ + D+L QS N +++ AE++ ++AK E+ ++ +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 495 QLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTA 554
R KA+ S+ + L+ + N M +
Sbjct: 1469 AEAREKETKAL-----SLARALEEAMEQKAELERLNKQFRTEMEDL-------------- 1509
Query: 555 GNRLFYHIVDSDEVSTKIL-MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKL 613
+ D+V + +E +K L +V + +L+ + T DA KL
Sbjct: 1510 -------MSSKDDVGKSVHELEKSKRALEQQVEEMK-TQLEELEDELQATEDA-----KL 1556
Query: 614 RYNPRFDKAFKHVFGKTLICR---SMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYD 670
R +A K F + L R S E QL R LE D
Sbjct: 1557 RLEVNL-QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE---------------D 1600
Query: 671 TRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKA 730
RK R +K E +L +LEA + ++ +N + ++ +L QM+ + +A
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHI-DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 731 SRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDL-LSQL 789
SR+ IL++ K ++K + E + Q L + E + + R+ L E+ L
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 790 SLEDQKRVDA----LNDEIRQLQQENRQLLNERIKLEGI-ITRVETYL---------NEN 835
+LE+++R++A L +E+ + +Q N +L+N+R+K + I ++ T L NEN
Sbjct: 1720 ALEEKRRLEARIAQLEEELEE-EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 836 LRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIK 895
R++L++ +EL + GTV + + + A+ ++ E LDN + +A K
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL---EEQLDNETKERQAACK 1835
Query: 896 ELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFE 955
+++++ ++ K++ + +D + ++ + ++ LK+ + R+L +EA
Sbjct: 1836 QVRRTEKKLKDVLLQ-VDDERRNAEQYKDQADKASTRLKQLK------RQLEEAEEEA-- 1886
Query: 956 KYQTLSLKQLFRKLE 970
+ S ++L R+LE
Sbjct: 1887 QRANASRRKLQRELE 1901
Score = 116 bits (291), Expect = 1e-25
Identities = 186/885 (21%), Positives = 372/885 (42%), Gaps = 82/885 (9%)
Query: 170 ERKEESISLMKETEGKREKINELLKYIEERLHTLE---EEKEELAQYQKWDKMRRALEYT 226
E+ + L E E R ++ + +EE H LE EE+EE Q+ + +K +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 227 IYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKE 286
++L E + +L ++ T+ K ++L + Q D+ + ++ + L+ +I+
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 287 EKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQK-------LLEKIEE 339
+ + + K + K E DL++ L +QR+ L K R+K L ++I E
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 340 KQKELAETEPKFNSVKEKEERGIARL-AQATQERTDLYAKQGRGSQFTSKEERDKWIKKE 398
Q ++AE + + +E+ + +AR+ +A Q+ L + SQ + +E + +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 399 LKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEV 458
++ D ++ A+ +LEDT + E +K +Q++N +K +EE E
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE------EA 1180
Query: 459 KNKKDELQSERNYLWR--EENAEQ-QALAAKREDLEKKQQLLRAATGKAILNGIDSINKV 515
K + ++Q R + EE AEQ + + +LEK +Q L G + N+V
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG-------ELANEV 1233
Query: 516 LDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILME 575
+ KG ++H + + + + V +++ V+ D V+ +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEA-QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 576 FNKMN-LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICR 634
+K + L + + L D ++ E + + +KL+ +F+ + +
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK 1352
Query: 635 -SMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELE 693
++E A D D V G L RK + +L+ ++ EE++ +
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSV---GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409
Query: 694 --AKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK----EKRQ 747
K L++ ++ + ++D +E +Q+KF D +L+E K + E+R
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF----DQLLAEEKTISAKYAEERD 1465
Query: 748 QSEKTFMPKQRSLQSLEASL-HAME--STRESLKAELGTDLLSQLSLEDQ--KRVDALND 802
++E K+ SL +L AME + E L + T++ +S +D K V L
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 803 EIRQLQQENRQLLNERIKLEGIITRVE---TYLNENLRKRLDQVEQELNELRETEGGTVL 859
R L+Q+ ++ + +LE + E L NL+ Q E++L E
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE------- 1578
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDT 919
+ + + + ++V++ A ED A K+L+ + K++E H+D+ N +
Sbjct: 1579 -QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL---KDLE-AHIDSANKNR 1633
Query: 920 KELEKMTNRQGMLLKKKEECMKKIRELGSLPQE--AFEKYQTLSLKQLFRKLEQCNTELK 977
E K + L + ++CM+++ + + +E A K LK + ++ Q EL
Sbjct: 1634 DEAIKQLRK---LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 978 KYSHVNKKA-------LDQFVNFS-------EQKEKLIKRQEELD 1008
++A D+ N S E+K +L R +L+
Sbjct: 1691 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735
Score = 113 bits (283), Expect = 1e-24
Identities = 210/1027 (20%), Positives = 429/1027 (41%), Gaps = 136/1027 (13%)
Query: 140 KQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEER 199
K K+ + + Q KL +E ++ ++R E + + E E K + + +L E
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKE---KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 200 LHTLEEE-KEELAQYQKWDKMRRALE--YTIYNQELNETRAKLDELS---AKRETSGEKS 253
+ LEE + E Q Q+ +K RR LE T + ++ E +A++ EL AK+E E
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE--ELQ 1086
Query: 254 RQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL--ELKA-- 309
L +++A K +++ +REL+++IS ++E+ E A R + KQ+ L EL+A
Sbjct: 1087 AALARVEEEAAQKNMALKK-IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK 1145
Query: 310 ---KDLQDELAGNSEQR----------KRLLKERQKLLE-KIEEKQKELAETEPKFNSVK 355
+D D A E R K+ L+E K E +I+E +++ ++ +
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 356 EKEERGIARLAQATQ----ERTDLYAK-----QGRGSQFTSKEERDKWIKKELKSLDQAI 406
E+ +R A L +A Q ER +L + QG+G E + K ++ +L+ L
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS----EHKRKKVEAQLQELQVKF 1261
Query: 407 NDKKR-------QIAAIHKDLED-------TEANKEKNLEQYNKLDQDLNEVKARVEELD 452
N+ +R ++ + +L++ +++ K + ++ L+ L + + ++E +
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 453 RKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSI 512
R+ + K +++ E+N + E++A + +LEK+ L A DS+
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEA----KHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 513 N--KVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGN---RLFYHIVDSDE 567
+ + +RK +Q G+ + E + A Y +E T L +VD D
Sbjct: 1378 GCLETAEEVKRK-----LQKDLEGLSQRHEE-KVAAYDKLEKTKTRLQQELDDLLVDLDH 1431
Query: 568 VSTKILMEFNKMN----LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAF 623
K L E + + RD A E + K
Sbjct: 1432 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE---------------KET 1476
Query: 624 KHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVR 683
K + + +ME +L R +E D +S + + ++ KS+ L++ V
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEME-DLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Query: 684 KAEEELGELEAKLNE------NLRRNIERINNEIDQ-LMNQMQQIETQQRKFKASRDSIL 736
+ + +L ELE +L L N++ + + ++ L + +Q E ++++ +
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Query: 737 SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLS--LEDQ 794
+E++ +++R + + L+ LEA + + R+ +L L +Q+ + +
Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-RKLQAQMKDCMREL 1654
Query: 795 KRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQEL-NELRET 853
A +EI +EN + L + ++ E I + E E +++ Q EL +E+ +
Sbjct: 1655 DDTRASREEILAQAKENEKKL-KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1713
Query: 854 EG-GTVLTATTSELEA----INKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNME 908
G G + LEA + + +++ +E +++ + K I ++ + N+E
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL----NLE 1769
Query: 909 KEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRK 968
+ H + ++LE+ + L++ E +K + EA K L +QL +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEA--KIAQLE-EQLDNE 1826
Query: 969 LEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLE------ 1022
++ K+ KK D + +++ + +++ D+ + +L LE
Sbjct: 1827 TKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEA 1886
Query: 1023 ----------LRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLV----MKKGDVEGSQSQ 1068
R+ E T +++ S + KL G +V +KG +GS +
Sbjct: 1887 QRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
Query: 1069 DEGEGSG 1075
+G+ G
Sbjct: 1947 VDGKADG 1953
Score = 110 bits (275), Expect = 8e-24
Identities = 171/899 (19%), Positives = 373/899 (41%), Gaps = 113/899 (12%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY 228
+E+ EE S ++ + ++ LK +EE LE++ +LA+ +K + R A E+T
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA-EFTTN 1007
Query: 229 NQELNETRAKLDELSAKRET----------SGEKSRQ--------LRDAQQDARDKMEDI 270
E E L +L K E EK RQ L D D++ ++
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 271 ERQVRELKTKISAMKEE-------KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQR 323
+ Q+ ELK +++ +EE E+ +A++ +K+ +LE + +LQ++L R
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 324 KRLLKERQKLLEKIEEKQKELAET---EPKFNSVKEKEERGIARLAQATQERTDLYAKQG 380
+ K+++ L E++E + EL +T ++ K E+ + L + +E + Q
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 381 RG---------SQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNL 431
+ + + E+ K +K L+ Q + +++ ++A K L + + E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE--- 1244
Query: 432 EQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQ--------------SERNYLWREEN 477
+ K++ L E++ + E +R E+ +K +LQ S+ + L ++ +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 478 AEQQALAAKREDL--EKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNG-YHG 534
A + L +E L E +Q+L + K + + +S + L+ N Q H
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 535 IVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLD 594
V + + C+E ++EV K+ + ++ E +KL+
Sbjct: 1365 QVADMKKKMEDSVGCLET------------AEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412
Query: 595 VRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLE 654
+K R D + + ++E + + T+
Sbjct: 1413 K---------------TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 655 GDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQL 714
R + L L + + +A E+ ELE +LN+ R +E + + D +
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE-RLNKQFRTEMEDLMSSKDDV 1516
Query: 715 MNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR 774
+ ++E +R + + + ++++ L+++ Q +E + + +LQ+++A R
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 775 ESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNE 834
+ E L+ Q V + E+ +++ + R KLE + +E ++ +
Sbjct: 1577 DEQSEEKKKQLVRQ--------VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI-D 1627
Query: 835 NLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGI 894
+ K D+ ++L +L+ + EL+ ++ +A++++ + + EA +
Sbjct: 1628 SANKNRDEAIKQLRKLQ-----AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682
Query: 895 KELQKSM---ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQ 951
+LQ+ + ER K ++ D + E+ + + + L++K +I +L +
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDEL---ADEIANSSGKGALALEEKRRLEARIAQLEEELE 1739
Query: 952 EAFEKYQTLS--LKQLFRKLEQCNTEL---KKYSHVNKKALDQFVNFSEQKEKLIKRQE 1005
E + ++ LK+ +++Q NT+L + ++ N+ A Q + KE +K QE
Sbjct: 1740 EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER--QNKELKVKLQE 1796
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/323 (21%), Positives = 145/323 (44%), Gaps = 40/323 (12%)
Query: 209 ELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME 268
+L +Q W + +++ E AK +EL RE +QL A ++ +ME
Sbjct: 821 KLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE------KQL--AAENRLTEME 872
Query: 269 DIERQVRELKTKISAMKEEKEQLSAERQEQIKQRT----KLELKAKDLQDELAGNSEQRK 324
++ Q+ K ++ + + +L AE +E + T +LE DL+ + E+ +
Sbjct: 873 TLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ 932
Query: 325 RLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL------YAK 378
L E++K+ + I+E +++L E E ++ ++ A+L + +E+ L AK
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992
Query: 379 QGR---------GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEK 429
+ + + T +EE+ K + K + I D + ++ K ++ E + K
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 430 NLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKR-- 487
L + E++A++ EL ++ K++ELQ+ + EE A Q+ +A K+
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELK---MQLAKKEEELQAALARV--EEEAAQKNMALKKIR 1107
Query: 488 ------EDLEKKQQLLRAATGKA 504
+L++ + RA+ KA
Sbjct: 1108 ELESQISELQEDLESERASRNKA 1130
Score = 59.7 bits (143), Expect = 2e-08
Identities = 61/262 (23%), Positives = 121/262 (46%), Gaps = 15/262 (5%)
Query: 111 LDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMAT-APDSQRLKLLREVAGT---- 165
L K D M L+ SR I+ Q K N+ + +++ ++L E+A
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREE---ILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 166 RVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW--DKMRRA- 222
R + ++E + + GK E + +E R+ LEEE EE + D++++A
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 223 LEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMED-IERQVRELKTKI 281
L+ N +LN R+ + R+ ++++L+ Q+ ++ + + L+ KI
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1816
Query: 282 SAMKEEKEQLSAERQEQIKQRTKLELKAKDL---QDELAGNSEQRKRLLKERQKLLEKIE 338
+ ++E+ + + ERQ KQ + E K KD+ D+ N+EQ K + L++++
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876
Query: 339 EKQKELAETEPKFNSVKEKEER 360
+ +E E + N+ + K +R
Sbjct: 1877 RQLEEAEEEAQRANASRRKLQR 1898
Score = 53.1 bits (126), Expect = 2e-06
Identities = 90/393 (22%), Positives = 168/393 (42%), Gaps = 44/393 (11%)
Query: 716 NQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRE 775
N++ ++ET Q + A + + +++ E ++E+ Q LE H +E+ E
Sbjct: 866 NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVE 925
Query: 776 SLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVET--YLN 833
+ E L + Q+ + L +++ + + ++L E++ E + ++E +
Sbjct: 926 --EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983
Query: 834 ENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAG 893
E+ +L + E++L E R E T LT + +++ K A DL+ + + E
Sbjct: 984 EDQNCKLAK-EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 894 IKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEE--------------- 938
+EL+K+ + + + D I EL+ M L KKEE
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQI----AELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 939 ---CMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKAL-DQFVNFS 994
+KKIREL S E E + S + K E+ +L + K L D + +
Sbjct: 1099 KNMALKKIRELESQISELQEDLE--SERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 995 EQKEKLIKRQEELDRGYKSIMELMNVLELRKYEA-IQLTFKQVSKNFSEVFQKL--VPGG 1051
Q+E KR++E++ K++ E E + +EA IQ ++ S+ E+ ++L
Sbjct: 1157 AQQELRSKREQEVNILKKTLEE-----EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 1052 KATLVMKKGDVEGSQSQDEGE------GSGESE 1078
KA L K +E + + E G G+SE
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Score = 48.5 bits (114), Expect = 4e-05
Identities = 87/402 (21%), Positives = 165/402 (41%), Gaps = 58/402 (14%)
Query: 670 DTRKSRLELQK-----DVRKAEEELGELE------AKLNENLRRNIERINNEIDQLMNQM 718
++ + +L+L+K ++K EEE LE AK + L I + + +
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 719 QQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLK 778
+ + + K +A + ++ +++RQ+ EKT + LE + L+
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKT-------RRKLEGDSTDLSDQIAELQ 1068
Query: 779 AELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRK 838
A++ +L QL+ ++++ AL + Q+N L R +LE I+ ++ L E+ R
Sbjct: 1069 AQI-AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR-ELESQISELQEDL-ESERA 1125
Query: 839 RLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQ 898
++ E++ +L E ELEA+ ++DT+ + K E + L+
Sbjct: 1126 SRNKAEKQKRDLGE------------ELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 899 KSME--------RWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIREL---- 946
K++E + + M ++H A+ ++LE+ + L K K+ + EL
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 947 -----GSLPQEAFEKYQTLSLKQL---FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKE 998
G E K L++L F + E+ TEL + LD Q +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 999 ----KLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQV 1036
KL K L+ + EL+ E R+ ++ KQV
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQE-ENRQKLSLSTKLKQV 1334
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 117 bits (293), Expect = 7e-26
Identities = 208/995 (20%), Positives = 397/995 (39%), Gaps = 196/995 (19%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHT 202
K+ D Q KL +E ++ +ER + + + E E K + + +L E +
Sbjct: 982 KLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 203 LEEE-KEELAQYQKWDKMRRALE--YTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
LE K+E Q+ +K++R LE + +++++ + +A++ EL + E+ +
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL--ELKA--KDLQDE 315
D + + +++REL+ IS ++E+ + A R + KQ+ L EL+A +L+D
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL 375
L + Q++ K Q++ + +E E + +++K + + L + ++
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQA---INDKKRQIAA----------------- 415
A + Q KE D + EL+ L QA + KK+++ A
Sbjct: 1219 KANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 416 -----IHK----------DLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
+HK L + E K + L L + + ++E R+ V
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 461 KKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL--RAATGKAILNGIDSINKVLDH 518
K +L+ ERN L + + E +A +++LE+ L + + K L S + L+
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 519 FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH----IVDSDEVSTKILM 574
+++ + ++N + +E + A Y +E T NRL +VD D +++
Sbjct: 1393 GKKR-FQKEIEN-----LTQQYEEKAAAYDKLEKTK-NRLQQELDDLVVDLDN-QRQLVS 1444
Query: 575 EFNKMN-----LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
K L E + D RD A E + K K +
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE---------------KETKALSLA 1489
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
+ ++E +L R M +E D VS + + ++ KS+ L+ + + + +L
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 690 GELEAKL-------------------------------NENLRRNIERINNEID------ 712
ELE +L NE RR ++R +E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 713 ---------------------------------QLMNQMQQIETQQRKF-------KASR 732
+ + Q+++++ Q + F +ASR
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668
Query: 733 DSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLE 792
D I + K ++K + E M Q L + E + + +E L EL + L + +L+
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D+KR L I QL++E L E+ +E + RV RK Q EQ NEL
Sbjct: 1729 DEKR--RLEARIAQLEEE---LEEEQGNMEAMSDRV--------RKATQQAEQLSNEL-A 1774
Query: 853 TEGGTVL--TATTSELEAINKRVKDTMARSE-----DLDNSIDKTEAGIKELQKSMERWK 905
TE T + +LE NK ++ + E ++I EA I +L++ +E+
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 906 NMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ ++ K+L++ +LL+ ++E R++ +E EK +KQL
Sbjct: 1835 REKQAATKSLKQKDKKLKE------ILLQVEDE-----RKMAEQYKEQAEK-GNARVKQL 1882
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKL 1000
R+LE+ E ++ + +K + +E E +
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 115 bits (289), Expect = 2e-25
Identities = 196/894 (21%), Positives = 355/894 (39%), Gaps = 109/894 (12%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L +V + KE+ + KE + K E NEL K +E++ L EEK L +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NEL-KELEQKHSQLTEEKNLLQEQL 896
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
+ E +Y E E R +L +AK++ E ++ ++ D+ + ++ +
Sbjct: 897 Q-------AETELY-AEAEEMRVRL---AAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
+++ ++ ++E+ E+ A RQ+ ++ E K K L+DE+ +Q +L KER+ L
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 335 EKIEEKQKELAETEPK---FNSVKEKEERGIARL-------AQATQERTDLYAK-QGRGS 383
E+I + LAE E K +K K E I+ L ++ QE L K +G S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
F +++ L I + K Q+A ++L+ A + + Q N + + E
Sbjct: 1066 DF----------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL---EKKQQLLRAA 500
++ + +L + +++ + ++ R+ E +AL + ED QQ LRA
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQK----RDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
+ + + K LD R Q VQ E VE +
Sbjct: 1172 REQE----VTVLKKALDEETRSHEAQ-VQ-----------EMRQKHAQAVEELTEQLEQF 1215
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
++ K +E +L GE+ L K +V + SK R
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR-------K 673
K + +E T + I L D S L+ DT+ +
Sbjct: 1276 AELNDKVHK--LQNEVESVTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR 1329
Query: 674 SRLELQKDVRKAEEELGELEAKLNENL--RRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+L + +R+ EEE L+ +L+E + ++N+ER + + Q K
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER----------HISTLNIQLSDSKKK 1379
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSL 791
S ++ L+E +++ +K + + A+ +E T+ L+ EL DL+ + L
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLV--VDL 1436
Query: 792 EDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR 851
++Q++ L + + Q++ QLL E + Y +E R + E+E L
Sbjct: 1437 DNQRQ---LVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALS 1487
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
ELE NK +K A EDL +S D + EL+KS K +
Sbjct: 1488 LARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKNVHELEKS----KRALETQ 1540
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971
M+ + +ELE + E M+ ++ +A ++ +QL R+L +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 972 CNTELKK-------YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELM 1018
TEL+ + KK + Q + IK +EE + + + M
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Score = 96.3 bits (238), Expect = 2e-19
Identities = 153/815 (18%), Positives = 340/815 (41%), Gaps = 103/815 (12%)
Query: 209 ELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME 268
+L +Q W + ++ E +AK DEL +E + +L++ +Q E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 269 D--IERQVRELKTKISAMKEE-KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
+ + ++ + +T++ A EE + +L+A++QE LE +++ L ++ ++
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE-------LEEILHEMEARLEEEEDRGQQ 940
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF 385
L ER+K+ +++ + +++L E E ++ ++ A++ + E
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-------------I 987
Query: 386 TSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQY-NKLDQDLNEV 444
++++ + KE K L++ I+D +A E K KNL + NK + ++E+
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEKAKNLTKLKNKHESMISEL 1039
Query: 445 KARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQA-LAAKREDLEKKQQLLRAATGK 503
+ R+++ ++ E++ K +L+ + + + E+ A+ QA +A + L KK++ L+AA +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 504 AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEV---TAGNRLFY 560
+ + I N L R + H+ + + + + E A E G L
Sbjct: 1099 -LDDEIAQKNNALKKIRE--LEGHISD-----LQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 561 HIVD-SDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRF 619
+ D + + + + EVT L + ET + ++R
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVL-------KKALDEETRSHEAQVQEMRQ---- 1199
Query: 620 DKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQ 679
KH + +E + + TLE + L G +++ E++
Sbjct: 1200 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD----LAGELRVLGQAKQEVE 1251
Query: 680 KDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM 739
+K E ++ EL++K ++ R E +N+++ +L N+++ + + + + ++
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
L + Q +++ + R ++ L +E R SL+ +L ++ ++ +LE
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE------- 1363
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
R + N QL + + KL+ + VE E +KR + + L + E +
Sbjct: 1364 -----RHISTLNIQLSDSKKKLQDFASTVEAL--EEGKKRFQKEIENLTQQYEEK----- 1411
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERW-------KNMEKEHM 912
A +LE R++ + +DL +D + L+K ++ KN+ ++
Sbjct: 1412 AAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 913 DAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC 972
D + E + + L + EE ++ EL E K ++ L +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDLVSSKDDV 1523
Query: 973 NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEEL 1007
+ + +K+AL+ E K +L + ++EL
Sbjct: 1524 GKNVHELEK-SKRALE--TQMEEMKTQLEELEDEL 1555
Score = 67.4 bits (163), Expect = 8e-11
Identities = 75/389 (19%), Positives = 164/389 (42%), Gaps = 58/389 (14%)
Query: 180 KETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQ---ELNETR 236
++ + + E+ E + ++ +LH E E E+ ++ +RAL + +L +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELED-------ERKQRALAAAAKKKLEGDLKDLE 1630
Query: 237 AKLDELSAKRETSGEKSR----QLRDAQ---QDARDKMEDIERQVRELKTKISAMKEEKE 289
+ D RE + ++ R Q++D Q +DAR ++I +E + K +++ +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEP 349
QL + + R + +L+ ++L +ELA + R L E+++L +I + ++EL E +
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 350 KFNSVKEKEERGIARLAQATQE-RTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
++ ++ + + Q + E T+ Q S E ++K ++ +L ++ A+
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 409 K-KRQIAAIH--------------------------KD---------LEDTEANKEKNLE 432
K K IAA+ KD +ED E+ E
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 433 QYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEK 492
Q K + + ++K ++EE + + + + +LQ E + A + + A + L +
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Query: 493 KQQL----LRAATGKAILNGIDSINKVLD 517
+ R + G+ ++ D + D
Sbjct: 1931 GNETSFVPSRRSGGRRVIENADGSEEETD 1959
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/400 (21%), Positives = 168/400 (42%), Gaps = 37/400 (9%)
Query: 677 ELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSIL 736
EL+ ++K E+ ELE KL L + + +I L Q+ +++ Q K + + L
Sbjct: 1038 ELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 737 SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR---ESLKAELGTDLLS-QLSLE 792
+ + ++ + K + + L+ L + + R E K +LG +L + + LE
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D A E+R +++ +L + + E TR + +R++ Q +EL E E
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 853 T--EGGTVLTATTSELEAINKRVKDTMA----RSEDLDNSIDKTEAGIKELQKSMERWKN 906
L LE N + + +++++ K EA ++ELQ +
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQE--------AFEKYQ 958
E D ++ E+E +T GML + + + +K +++ SL + E Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 959 TLSLKQLFRKLE--------QCNTELKKYSHVNKKALDQFVNFSEQKEKL---IKRQEEL 1007
L++ R+LE Q + E++ ++ + + S+ K+KL E L
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 1008 DRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKL 1047
+ G K + + L ++YE + ++ K + + Q+L
Sbjct: 1391 EEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQEL 1429
Score = 56.2 bits (134), Expect = 2e-07
Identities = 79/411 (19%), Positives = 171/411 (41%), Gaps = 64/411 (15%)
Query: 668 YYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
Y + + R+ L ++ EE L E+EA+L E R QQ++ +++K
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG---------------QQLQAERKK 947
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
+ +++ + RQ+ + + + ++ LE + M+ L E LL
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE--RKLL- 1004
Query: 788 QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYL--NENLRKRLDQVEQ 845
++R+ L + + +++ + L + K E +I+ +E L E R+ L+++++
Sbjct: 1005 ------EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 846 ELN-------------ELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEA 892
+L + + E L EL+A R+ D +A+ + I + E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 893 GIKELQKSM----------ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
I +LQ+ + E+ K E ++A+ + ++ T Q L K+E+ +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+++ +L +E T S + +++ Q K++ ++ +Q F K L K
Sbjct: 1179 LKK--ALDEE------TRSHEAQVQEMRQ------KHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKA 1053
++ L++ + + VL K E ++ K++ E+ K G +A
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQE-VEHKKKKLEAQVQELQSKCSDGERA 1274
Score = 53.1 bits (126), Expect = 2e-06
Identities = 67/294 (22%), Positives = 124/294 (42%), Gaps = 52/294 (17%)
Query: 111 LDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLK--LLREVAGTRVY 168
L K D LE A SR + K+ + + D +L+ L +
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW--DKMRRALEYT 226
D KEE + + R + + + +E R+ LEEE EE + D++R+A +
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 227 IYNQELNETRAKLDELSAKRETS--GEKSRQLRDAQ-QDARDKMEDIERQVRE------- 276
++L+ +EL+ +R T+ E +RQ + Q ++ R K+ ++E V+
Sbjct: 1767 ---EQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 277 -LKTKISAMKEEKEQLSAERQ---------------------------EQIKQRT-KLEL 307
L+ KI+ ++E+ EQ + E+Q EQ K++ K
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 308 KAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERG 361
+ K L+ +L E+ +R+ R+KL +++E + + N++K K RG
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRG 1931
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 117 bits (293), Expect = 7e-26
Identities = 208/995 (20%), Positives = 397/995 (39%), Gaps = 196/995 (19%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHT 202
K+ D Q KL +E ++ +ER + + + E E K + + +L E +
Sbjct: 989 KLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 203 LEEE-KEELAQYQKWDKMRRALE--YTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
LE K+E Q+ +K++R LE + +++++ + +A++ EL + E+ +
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL--ELKA--KDLQDE 315
D + + +++REL+ IS ++E+ + A R + KQ+ L EL+A +L+D
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL 375
L + Q++ K Q++ + +E E + +++K + + L + ++
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQA---INDKKRQIAA----------------- 415
A + Q KE D + EL+ L QA + KK+++ A
Sbjct: 1226 KANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 416 -----IHK----------DLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
+HK L + E K + L L + + ++E R+ V
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 461 KKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL--RAATGKAILNGIDSINKVLDH 518
K +L+ ERN L + + E +A +++LE+ L + + K L S + L+
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 519 FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH----IVDSDEVSTKILM 574
+++ + ++N + +E + A Y +E T NRL +VD D +++
Sbjct: 1400 GKKR-FQKEIEN-----LTQQYEEKAAAYDKLEKTK-NRLQQELDDLVVDLDN-QRQLVS 1451
Query: 575 EFNKMN-----LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
K L E + D RD A E + K K +
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE---------------KETKALSLA 1496
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
+ ++E +L R M +E D VS + + ++ KS+ L+ + + + +L
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 690 GELEAKL-------------------------------NENLRRNIERINNEID------ 712
ELE +L NE RR ++R +E +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 713 ---------------------------------QLMNQMQQIETQQRKF-------KASR 732
+ + Q+++++ Q + F +ASR
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675
Query: 733 DSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLE 792
D I + K ++K + E M Q L + E + + +E L EL + L + +L+
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D+KR L I QL++E L E+ +E + RV RK Q EQ NEL
Sbjct: 1736 DEKR--RLEARIAQLEEE---LEEEQGNMEAMSDRV--------RKATQQAEQLSNEL-A 1781
Query: 853 TEGGTVL--TATTSELEAINKRVKDTMARSE-----DLDNSIDKTEAGIKELQKSMERWK 905
TE T + +LE NK ++ + E ++I EA I +L++ +E+
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 906 NMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ ++ K+L++ +LL+ ++E R++ +E EK +KQL
Sbjct: 1842 REKQAATKSLKQKDKKLKE------ILLQVEDE-----RKMAEQYKEQAEK-GNARVKQL 1889
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKL 1000
R+LE+ E ++ + +K + +E E +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 115 bits (289), Expect = 2e-25
Identities = 196/894 (21%), Positives = 355/894 (39%), Gaps = 109/894 (12%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L +V + KE+ + KE + K E NEL K +E++ L EEK L +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NEL-KELEQKHSQLTEEKNLLQEQL 903
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
+ E +Y E E R +L +AK++ E ++ ++ D+ + ++ +
Sbjct: 904 Q-------AETELY-AEAEEMRVRL---AAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
+++ ++ ++E+ E+ A RQ+ ++ E K K L+DE+ +Q +L KER+ L
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 335 EKIEEKQKELAETEPK---FNSVKEKEERGIARL-------AQATQERTDLYAK-QGRGS 383
E+I + LAE E K +K K E I+ L ++ QE L K +G S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
F +++ L I + K Q+A ++L+ A + + Q N + + E
Sbjct: 1073 DF----------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL---EKKQQLLRAA 500
++ + +L + +++ + ++ R+ E +AL + ED QQ LRA
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQK----RDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
+ + + K LD R Q VQ E VE +
Sbjct: 1179 REQE----VTVLKKALDEETRSHEAQ-VQ-----------EMRQKHAQAVEELTEQLEQF 1222
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
++ K +E +L GE+ L K +V + SK R
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR-------K 673
K + +E T + I L D S L+ DT+ +
Sbjct: 1283 AELNDKVHK--LQNEVESVTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR 1336
Query: 674 SRLELQKDVRKAEEELGELEAKLNENL--RRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+L + +R+ EEE L+ +L+E + ++N+ER + + Q K
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER----------HISTLNIQLSDSKKK 1386
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSL 791
S ++ L+E +++ +K + + A+ +E T+ L+ EL DL+ + L
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLV--VDL 1443
Query: 792 EDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR 851
++Q++ L + + Q++ QLL E + Y +E R + E+E L
Sbjct: 1444 DNQRQ---LVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALS 1494
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
ELE NK +K A EDL +S D + EL+KS K +
Sbjct: 1495 LARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKNVHELEKS----KRALETQ 1547
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971
M+ + +ELE + E M+ ++ +A ++ +QL R+L +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 972 CNTELKK-------YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELM 1018
TEL+ + KK + Q + IK +EE + + + M
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Score = 96.3 bits (238), Expect = 2e-19
Identities = 153/815 (18%), Positives = 340/815 (41%), Gaps = 103/815 (12%)
Query: 209 ELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME 268
+L +Q W + ++ E +AK DEL +E + +L++ +Q E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 269 D--IERQVRELKTKISAMKEE-KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
+ + ++ + +T++ A EE + +L+A++QE LE +++ L ++ ++
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE-------LEEILHEMEARLEEEEDRGQQ 947
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF 385
L ER+K+ +++ + +++L E E ++ ++ A++ + E
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-------------I 994
Query: 386 TSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQY-NKLDQDLNEV 444
++++ + KE K L++ I+D +A E K KNL + NK + ++E+
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEKAKNLTKLKNKHESMISEL 1046
Query: 445 KARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQA-LAAKREDLEKKQQLLRAATGK 503
+ R+++ ++ E++ K +L+ + + + E+ A+ QA +A + L KK++ L+AA +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 504 AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEV---TAGNRLFY 560
+ + I N L R + H+ + + + + E A E G L
Sbjct: 1106 -LDDEIAQKNNALKKIRE--LEGHISD-----LQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 561 HIVD-SDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRF 619
+ D + + + + EVT L + ET + ++R
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVL-------KKALDEETRSHEAQVQEMRQ---- 1206
Query: 620 DKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQ 679
KH + +E + + TLE + L G +++ E++
Sbjct: 1207 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD----LAGELRVLGQAKQEVE 1258
Query: 680 KDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM 739
+K E ++ EL++K ++ R E +N+++ +L N+++ + + + + ++
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
L + Q +++ + R ++ L +E R SL+ +L ++ ++ +LE
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE------- 1370
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
R + N QL + + KL+ + VE E +KR + + L + E +
Sbjct: 1371 -----RHISTLNIQLSDSKKKLQDFASTVEAL--EEGKKRFQKEIENLTQQYEEK----- 1418
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERW-------KNMEKEHM 912
A +LE R++ + +DL +D + L+K ++ KN+ ++
Sbjct: 1419 AAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 913 DAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC 972
D + E + + L + EE ++ EL E K ++ L +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDLVSSKDDV 1530
Query: 973 NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEEL 1007
+ + +K+AL+ E K +L + ++EL
Sbjct: 1531 GKNVHELEK-SKRALE--TQMEEMKTQLEELEDEL 1562
Score = 67.4 bits (163), Expect = 8e-11
Identities = 75/389 (19%), Positives = 164/389 (42%), Gaps = 58/389 (14%)
Query: 180 KETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQ---ELNETR 236
++ + + E+ E + ++ +LH E E E+ ++ +RAL + +L +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELED-------ERKQRALAAAAKKKLEGDLKDLE 1637
Query: 237 AKLDELSAKRETSGEKSR----QLRDAQ---QDARDKMEDIERQVRELKTKISAMKEEKE 289
+ D RE + ++ R Q++D Q +DAR ++I +E + K +++ +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEP 349
QL + + R + +L+ ++L +ELA + R L E+++L +I + ++EL E +
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 350 KFNSVKEKEERGIARLAQATQE-RTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
++ ++ + + Q + E T+ Q S E ++K ++ +L ++ A+
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 409 K-KRQIAAIH--------------------------KD---------LEDTEANKEKNLE 432
K K IAA+ KD +ED E+ E
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 433 QYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEK 492
Q K + + ++K ++EE + + + + +LQ E + A + + A + L +
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Query: 493 KQQL----LRAATGKAILNGIDSINKVLD 517
+ R + G+ ++ D + D
Sbjct: 1938 GNETSFVPSRRSGGRRVIENADGSEEETD 1966
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/400 (21%), Positives = 168/400 (42%), Gaps = 37/400 (9%)
Query: 677 ELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSIL 736
EL+ ++K E+ ELE KL L + + +I L Q+ +++ Q K + + L
Sbjct: 1045 ELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 737 SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR---ESLKAELGTDLLS-QLSLE 792
+ + ++ + K + + L+ L + + R E K +LG +L + + LE
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D A E+R +++ +L + + E TR + +R++ Q +EL E E
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 853 T--EGGTVLTATTSELEAINKRVKDTMA----RSEDLDNSIDKTEAGIKELQKSMERWKN 906
L LE N + + +++++ K EA ++ELQ +
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQE--------AFEKYQ 958
E D ++ E+E +T GML + + + +K +++ SL + E Q
Sbjct: 1281 ARAELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 959 TLSLKQLFRKLE--------QCNTELKKYSHVNKKALDQFVNFSEQKEKL---IKRQEEL 1007
L++ R+LE Q + E++ ++ + + S+ K+KL E L
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 1008 DRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKL 1047
+ G K + + L ++YE + ++ K + + Q+L
Sbjct: 1398 EEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQEL 1436
Score = 56.2 bits (134), Expect = 2e-07
Identities = 79/411 (19%), Positives = 171/411 (41%), Gaps = 64/411 (15%)
Query: 668 YYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
Y + + R+ L ++ EE L E+EA+L E R QQ++ +++K
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG---------------QQLQAERKK 954
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
+ +++ + RQ+ + + + ++ LE + M+ L E LL
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE--RKLL- 1011
Query: 788 QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYL--NENLRKRLDQVEQ 845
++R+ L + + +++ + L + K E +I+ +E L E R+ L+++++
Sbjct: 1012 ------EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 846 ELN-------------ELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEA 892
+L + + E L EL+A R+ D +A+ + I + E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 893 GIKELQKSM----------ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
I +LQ+ + E+ K E ++A+ + ++ T Q L K+E+ +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+++ +L +E T S + +++ Q K++ ++ +Q F K L K
Sbjct: 1186 LKK--ALDEE------TRSHEAQVQEMRQ------KHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKA 1053
++ L++ + + VL K E ++ K++ E+ K G +A
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQE-VEHKKKKLEAQVQELQSKCSDGERA 1281
Score = 53.1 bits (126), Expect = 2e-06
Identities = 67/294 (22%), Positives = 124/294 (42%), Gaps = 52/294 (17%)
Query: 111 LDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLK--LLREVAGTRVY 168
L K D LE A SR + K+ + + D +L+ L +
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW--DKMRRALEYT 226
D KEE + + R + + + +E R+ LEEE EE + D++R+A +
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 227 IYNQELNETRAKLDELSAKRETS--GEKSRQLRDAQ-QDARDKMEDIERQVRE------- 276
++L+ +EL+ +R T+ E +RQ + Q ++ R K+ ++E V+
Sbjct: 1774 ---EQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 277 -LKTKISAMKEEKEQLSAERQ---------------------------EQIKQRT-KLEL 307
L+ KI+ ++E+ EQ + E+Q EQ K++ K
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 308 KAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERG 361
+ K L+ +L E+ +R+ R+KL +++E + + N++K K RG
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRG 1938
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 117 bits (293), Expect = 7e-26
Identities = 208/995 (20%), Positives = 397/995 (39%), Gaps = 196/995 (19%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHT 202
K+ D Q KL +E ++ +ER + + + E E K + + +L E +
Sbjct: 989 KLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 203 LEEE-KEELAQYQKWDKMRRALE--YTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
LE K+E Q+ +K++R LE + +++++ + +A++ EL + E+ +
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL--ELKA--KDLQDE 315
D + + +++REL+ IS ++E+ + A R + KQ+ L EL+A +L+D
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL 375
L + Q++ K Q++ + +E E + +++K + + L + ++
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQA---INDKKRQIAA----------------- 415
A + Q KE D + EL+ L QA + KK+++ A
Sbjct: 1226 KANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 416 -----IHK----------DLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
+HK L + E K + L L + + ++E R+ V
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 461 KKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL--RAATGKAILNGIDSINKVLDH 518
K +L+ ERN L + + E +A +++LE+ L + + K L S + L+
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 519 FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH----IVDSDEVSTKILM 574
+++ + ++N + +E + A Y +E T NRL +VD D +++
Sbjct: 1400 GKKR-FQKEIEN-----LTQQYEEKAAAYDKLEKTK-NRLQQELDDLVVDLDN-QRQLVS 1451
Query: 575 EFNKMN-----LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
K L E + D RD A E + K K +
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE---------------KETKALSLA 1496
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
+ ++E +L R M +E D VS + + ++ KS+ L+ + + + +L
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 690 GELEAKL-------------------------------NENLRRNIERINNEID------ 712
ELE +L NE RR ++R +E +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 713 ---------------------------------QLMNQMQQIETQQRKF-------KASR 732
+ + Q+++++ Q + F +ASR
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675
Query: 733 DSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLE 792
D I + K ++K + E M Q L + E + + +E L EL + L + +L+
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D+KR L I QL++E L E+ +E + RV RK Q EQ NEL
Sbjct: 1736 DEKR--RLEARIAQLEEE---LEEEQGNMEAMSDRV--------RKATQQAEQLSNEL-A 1781
Query: 853 TEGGTVL--TATTSELEAINKRVKDTMARSE-----DLDNSIDKTEAGIKELQKSMERWK 905
TE T + +LE NK ++ + E ++I EA I +L++ +E+
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 906 NMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ ++ K+L++ +LL+ ++E R++ +E EK +KQL
Sbjct: 1842 REKQAATKSLKQKDKKLKE------ILLQVEDE-----RKMAEQYKEQAEK-GNARVKQL 1889
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKL 1000
R+LE+ E ++ + +K + +E E +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 115 bits (289), Expect = 2e-25
Identities = 196/894 (21%), Positives = 355/894 (39%), Gaps = 109/894 (12%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L +V + KE+ + KE + K E NEL K +E++ L EEK L +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NEL-KELEQKHSQLTEEKNLLQEQL 903
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
+ E +Y E E R +L +AK++ E ++ ++ D+ + ++ +
Sbjct: 904 Q-------AETELY-AEAEEMRVRL---AAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
+++ ++ ++E+ E+ A RQ+ ++ E K K L+DE+ +Q +L KER+ L
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 335 EKIEEKQKELAETEPK---FNSVKEKEERGIARL-------AQATQERTDLYAK-QGRGS 383
E+I + LAE E K +K K E I+ L ++ QE L K +G S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
F +++ L I + K Q+A ++L+ A + + Q N + + E
Sbjct: 1073 DF----------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL---EKKQQLLRAA 500
++ + +L + +++ + ++ R+ E +AL + ED QQ LRA
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQK----RDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
+ + + K LD R Q VQ E VE +
Sbjct: 1179 REQE----VTVLKKALDEETRSHEAQ-VQ-----------EMRQKHAQAVEELTEQLEQF 1222
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
++ K +E +L GE+ L K +V + SK R
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR-------K 673
K + +E T + I L D S L+ DT+ +
Sbjct: 1283 AELNDKVHK--LQNEVESVTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR 1336
Query: 674 SRLELQKDVRKAEEELGELEAKLNENL--RRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+L + +R+ EEE L+ +L+E + ++N+ER + + Q K
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER----------HISTLNIQLSDSKKK 1386
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSL 791
S ++ L+E +++ +K + + A+ +E T+ L+ EL DL+ + L
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLV--VDL 1443
Query: 792 EDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR 851
++Q++ L + + Q++ QLL E + Y +E R + E+E L
Sbjct: 1444 DNQRQ---LVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALS 1494
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
ELE NK +K A EDL +S D + EL+KS K +
Sbjct: 1495 LARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKNVHELEKS----KRALETQ 1547
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971
M+ + +ELE + E M+ ++ +A ++ +QL R+L +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 972 CNTELKK-------YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELM 1018
TEL+ + KK + Q + IK +EE + + + M
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Score = 96.3 bits (238), Expect = 2e-19
Identities = 153/815 (18%), Positives = 340/815 (41%), Gaps = 103/815 (12%)
Query: 209 ELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME 268
+L +Q W + ++ E +AK DEL +E + +L++ +Q E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 269 D--IERQVRELKTKISAMKEE-KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
+ + ++ + +T++ A EE + +L+A++QE LE +++ L ++ ++
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE-------LEEILHEMEARLEEEEDRGQQ 947
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF 385
L ER+K+ +++ + +++L E E ++ ++ A++ + E
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-------------I 994
Query: 386 TSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQY-NKLDQDLNEV 444
++++ + KE K L++ I+D +A E K KNL + NK + ++E+
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEKAKNLTKLKNKHESMISEL 1046
Query: 445 KARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQA-LAAKREDLEKKQQLLRAATGK 503
+ R+++ ++ E++ K +L+ + + + E+ A+ QA +A + L KK++ L+AA +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 504 AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEV---TAGNRLFY 560
+ + I N L R + H+ + + + + E A E G L
Sbjct: 1106 -LDDEIAQKNNALKKIRE--LEGHISD-----LQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 561 HIVD-SDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRF 619
+ D + + + + EVT L + ET + ++R
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVL-------KKALDEETRSHEAQVQEMRQ---- 1206
Query: 620 DKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQ 679
KH + +E + + TLE + L G +++ E++
Sbjct: 1207 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD----LAGELRVLGQAKQEVE 1258
Query: 680 KDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM 739
+K E ++ EL++K ++ R E +N+++ +L N+++ + + + + ++
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
L + Q +++ + R ++ L +E R SL+ +L ++ ++ +LE
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE------- 1370
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
R + N QL + + KL+ + VE E +KR + + L + E +
Sbjct: 1371 -----RHISTLNIQLSDSKKKLQDFASTVEAL--EEGKKRFQKEIENLTQQYEEK----- 1418
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERW-------KNMEKEHM 912
A +LE R++ + +DL +D + L+K ++ KN+ ++
Sbjct: 1419 AAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 913 DAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC 972
D + E + + L + EE ++ EL E K ++ L +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDLVSSKDDV 1530
Query: 973 NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEEL 1007
+ + +K+AL+ E K +L + ++EL
Sbjct: 1531 GKNVHELEK-SKRALE--TQMEEMKTQLEELEDEL 1562
Score = 63.2 bits (152), Expect = 1e-09
Identities = 65/331 (19%), Positives = 144/331 (43%), Gaps = 31/331 (9%)
Query: 152 DSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINEL------LKYIEERLHTLEE 205
D ++ + L A ++ + K+ + +G+ E I +L +K + L
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 206 EKEEL-AQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDAR 264
++E+ A ++ +K ++LE + +L E A + + + E+ + + R
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 265 DKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRK 324
+ ++D + R L+ +I+ ++EE E+ + + K +A+ L +ELA +
Sbjct: 1732 NALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 325 RLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQ 384
+ RQ+L + +E + +L E E +VK K + IA L + + ++ R Q
Sbjct: 1789 KNESARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 385 FTSKEERDKWIKKELKSLDQAINDKKR--------------QIAAIHKDLEDTEANKEKN 430
+K + K K+LK + + D+++ ++ + + LE+ E ++
Sbjct: 1846 AATKSLKQK--DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 431 LEQYNKLDQDLNEVKARVEELDRKYYEVKNK 461
KL ++L+E E + R+ +K+K
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/400 (21%), Positives = 168/400 (42%), Gaps = 37/400 (9%)
Query: 677 ELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSIL 736
EL+ ++K E+ ELE KL L + + +I L Q+ +++ Q K + + L
Sbjct: 1045 ELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 737 SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR---ESLKAELGTDLLS-QLSLE 792
+ + ++ + K + + L+ L + + R E K +LG +L + + LE
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D A E+R +++ +L + + E TR + +R++ Q +EL E E
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 853 T--EGGTVLTATTSELEAINKRVKDTMA----RSEDLDNSIDKTEAGIKELQKSMERWKN 906
L LE N + + +++++ K EA ++ELQ +
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQE--------AFEKYQ 958
E D ++ E+E +T GML + + + +K +++ SL + E Q
Sbjct: 1281 ARAELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 959 TLSLKQLFRKLE--------QCNTELKKYSHVNKKALDQFVNFSEQKEKL---IKRQEEL 1007
L++ R+LE Q + E++ ++ + + S+ K+KL E L
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 1008 DRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKL 1047
+ G K + + L ++YE + ++ K + + Q+L
Sbjct: 1398 EEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQEL 1436
Score = 56.2 bits (134), Expect = 2e-07
Identities = 79/411 (19%), Positives = 171/411 (41%), Gaps = 64/411 (15%)
Query: 668 YYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
Y + + R+ L ++ EE L E+EA+L E R QQ++ +++K
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG---------------QQLQAERKK 954
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
+ +++ + RQ+ + + + ++ LE + M+ L E LL
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE--RKLL- 1011
Query: 788 QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYL--NENLRKRLDQVEQ 845
++R+ L + + +++ + L + K E +I+ +E L E R+ L+++++
Sbjct: 1012 ------EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 846 ELN-------------ELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEA 892
+L + + E L EL+A R+ D +A+ + I + E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 893 GIKELQKSM----------ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
I +LQ+ + E+ K E ++A+ + ++ T Q L K+E+ +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+++ +L +E T S + +++ Q K++ ++ +Q F K L K
Sbjct: 1186 LKK--ALDEE------TRSHEAQVQEMRQ------KHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKA 1053
++ L++ + + VL K E ++ K++ E+ K G +A
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQE-VEHKKKKLEAQVQELQSKCSDGERA 1281
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/113 (19%), Positives = 49/113 (43%), Gaps = 15/113 (13%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY 228
++ E + K + K +K+ E+L +E+ E+ KE+ +
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG--------------- 1882
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKI 281
N + + + +L+E + + R+L+ +A + E + R+V LK+K+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 117 bits (293), Expect = 7e-26
Identities = 208/995 (20%), Positives = 397/995 (39%), Gaps = 196/995 (19%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHT 202
K+ D Q KL +E ++ +ER + + + E E K + + +L E +
Sbjct: 982 KLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 203 LEEE-KEELAQYQKWDKMRRALE--YTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
LE K+E Q+ +K++R LE + +++++ + +A++ EL + E+ +
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL--ELKA--KDLQDE 315
D + + +++REL+ IS ++E+ + A R + KQ+ L EL+A +L+D
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL 375
L + Q++ K Q++ + +E E + +++K + + L + ++
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQA---INDKKRQIAA----------------- 415
A + Q KE D + EL+ L QA + KK+++ A
Sbjct: 1219 KANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 416 -----IHK----------DLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
+HK L + E K + L L + + ++E R+ V
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 461 KKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL--RAATGKAILNGIDSINKVLDH 518
K +L+ ERN L + + E +A +++LE+ L + + K L S + L+
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 519 FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH----IVDSDEVSTKILM 574
+++ + ++N + +E + A Y +E T NRL +VD D +++
Sbjct: 1393 GKKR-FQKEIEN-----LTQQYEEKAAAYDKLEKTK-NRLQQELDDLVVDLDN-QRQLVS 1444
Query: 575 EFNKMN-----LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
K L E + D RD A E + K K +
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE---------------KETKALSLA 1489
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
+ ++E +L R M +E D VS + + ++ KS+ L+ + + + +L
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 690 GELEAKL-------------------------------NENLRRNIERINNEID------ 712
ELE +L NE RR ++R +E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 713 ---------------------------------QLMNQMQQIETQQRKF-------KASR 732
+ + Q+++++ Q + F +ASR
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668
Query: 733 DSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLE 792
D I + K ++K + E M Q L + E + + +E L EL + L + +L+
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D+KR L I QL++E L E+ +E + RV RK Q EQ NEL
Sbjct: 1729 DEKR--RLEARIAQLEEE---LEEEQGNMEAMSDRV--------RKATQQAEQLSNEL-A 1774
Query: 853 TEGGTVL--TATTSELEAINKRVKDTMARSE-----DLDNSIDKTEAGIKELQKSMERWK 905
TE T + +LE NK ++ + E ++I EA I +L++ +E+
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 906 NMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ ++ K+L++ +LL+ ++E R++ +E EK +KQL
Sbjct: 1835 REKQAATKSLKQKDKKLKE------ILLQVEDE-----RKMAEQYKEQAEK-GNARVKQL 1882
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKL 1000
R+LE+ E ++ + +K + +E E +
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 115 bits (289), Expect = 2e-25
Identities = 196/894 (21%), Positives = 355/894 (39%), Gaps = 109/894 (12%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L +V + KE+ + KE + K E NEL K +E++ L EEK L +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NEL-KELEQKHSQLTEEKNLLQEQL 896
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
+ E +Y E E R +L +AK++ E ++ ++ D+ + ++ +
Sbjct: 897 Q-------AETELY-AEAEEMRVRL---AAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
+++ ++ ++E+ E+ A RQ+ ++ E K K L+DE+ +Q +L KER+ L
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 335 EKIEEKQKELAETEPK---FNSVKEKEERGIARL-------AQATQERTDLYAK-QGRGS 383
E+I + LAE E K +K K E I+ L ++ QE L K +G S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
F +++ L I + K Q+A ++L+ A + + Q N + + E
Sbjct: 1066 DF----------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL---EKKQQLLRAA 500
++ + +L + +++ + ++ R+ E +AL + ED QQ LRA
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQK----RDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
+ + + K LD R Q VQ E VE +
Sbjct: 1172 REQE----VTVLKKALDEETRSHEAQ-VQ-----------EMRQKHAQAVEELTEQLEQF 1215
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
++ K +E +L GE+ L K +V + SK R
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR-------K 673
K + +E T + I L D S L+ DT+ +
Sbjct: 1276 AELNDKVHK--LQNEVESVTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR 1329
Query: 674 SRLELQKDVRKAEEELGELEAKLNENL--RRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+L + +R+ EEE L+ +L+E + ++N+ER + + Q K
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER----------HISTLNIQLSDSKKK 1379
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSL 791
S ++ L+E +++ +K + + A+ +E T+ L+ EL DL+ + L
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL-DDLV--VDL 1436
Query: 792 EDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR 851
++Q++ L + + Q++ QLL E + Y +E R + E+E L
Sbjct: 1437 DNQRQ---LVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALS 1487
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
ELE NK +K A EDL +S D + EL+KS K +
Sbjct: 1488 LARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKNVHELEKS----KRALETQ 1540
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971
M+ + +ELE + E M+ ++ +A ++ +QL R+L +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 972 CNTELKK-------YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELM 1018
TEL+ + KK + Q + IK +EE + + + M
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Score = 96.3 bits (238), Expect = 2e-19
Identities = 153/815 (18%), Positives = 340/815 (41%), Gaps = 103/815 (12%)
Query: 209 ELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKME 268
+L +Q W + ++ E +AK DEL +E + +L++ +Q E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 269 D--IERQVRELKTKISAMKEE-KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
+ + ++ + +T++ A EE + +L+A++QE LE +++ L ++ ++
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE-------LEEILHEMEARLEEEEDRGQQ 940
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF 385
L ER+K+ +++ + +++L E E ++ ++ A++ + E
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-------------I 987
Query: 386 TSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQY-NKLDQDLNEV 444
++++ + KE K L++ I+D +A E K KNL + NK + ++E+
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEKAKNLTKLKNKHESMISEL 1039
Query: 445 KARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQA-LAAKREDLEKKQQLLRAATGK 503
+ R+++ ++ E++ K +L+ + + + E+ A+ QA +A + L KK++ L+AA +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASD-FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 504 AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEV---TAGNRLFY 560
+ + I N L R + H+ + + + + E A E G L
Sbjct: 1099 -LDDEIAQKNNALKKIRE--LEGHISD-----LQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 561 HIVD-SDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRF 619
+ D + + + + EVT L + ET + ++R
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVL-------KKALDEETRSHEAQVQEMRQ---- 1199
Query: 620 DKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQ 679
KH + +E + + TLE + L G +++ E++
Sbjct: 1200 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD----LAGELRVLGQAKQEVE 1251
Query: 680 KDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM 739
+K E ++ EL++K ++ R E +N+++ +L N+++ + + + + ++
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
L + Q +++ + R ++ L +E R SL+ +L ++ ++ +LE
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE------- 1363
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
R + N QL + + KL+ + VE E +KR + + L + E +
Sbjct: 1364 -----RHISTLNIQLSDSKKKLQDFASTVEAL--EEGKKRFQKEIENLTQQYEEK----- 1411
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERW-------KNMEKEHM 912
A +LE R++ + +DL +D + L+K ++ KN+ ++
Sbjct: 1412 AAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 913 DAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC 972
D + E + + L + EE ++ EL E K ++ L +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDLVSSKDDV 1523
Query: 973 NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEEL 1007
+ + +K+AL+ E K +L + ++EL
Sbjct: 1524 GKNVHELEK-SKRALE--TQMEEMKTQLEELEDEL 1555
Score = 63.2 bits (152), Expect = 1e-09
Identities = 65/331 (19%), Positives = 144/331 (43%), Gaps = 31/331 (9%)
Query: 152 DSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINEL------LKYIEERLHTLEE 205
D ++ + L A ++ + K+ + +G+ E I +L +K + L
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 206 EKEEL-AQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDAR 264
++E+ A ++ +K ++LE + +L E A + + + E+ + + R
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 265 DKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRK 324
+ ++D + R L+ +I+ ++EE E+ + + K +A+ L +ELA +
Sbjct: 1725 NALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 325 RLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQ 384
+ RQ+L + +E + +L E E +VK K + IA L + + ++ R Q
Sbjct: 1782 KNESARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 385 FTSKEERDKWIKKELKSLDQAINDKKR--------------QIAAIHKDLEDTEANKEKN 430
+K + K K+LK + + D+++ ++ + + LE+ E ++
Sbjct: 1839 AATKSLKQK--DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 431 LEQYNKLDQDLNEVKARVEELDRKYYEVKNK 461
KL ++L+E E + R+ +K+K
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/400 (21%), Positives = 168/400 (42%), Gaps = 37/400 (9%)
Query: 677 ELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSIL 736
EL+ ++K E+ ELE KL L + + +I L Q+ +++ Q K + + L
Sbjct: 1038 ELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 737 SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR---ESLKAELGTDLLS-QLSLE 792
+ + ++ + K + + L+ L + + R E K +LG +L + + LE
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 793 DQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
D A E+R +++ +L + + E TR + +R++ Q +EL E E
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 853 T--EGGTVLTATTSELEAINKRVKDTMA----RSEDLDNSIDKTEAGIKELQKSMERWKN 906
L LE N + + +++++ K EA ++ELQ +
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQE--------AFEKYQ 958
E D ++ E+E +T GML + + + +K +++ SL + E Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 959 TLSLKQLFRKLE--------QCNTELKKYSHVNKKALDQFVNFSEQKEKL---IKRQEEL 1007
L++ R+LE Q + E++ ++ + + S+ K+KL E L
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 1008 DRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKL 1047
+ G K + + L ++YE + ++ K + + Q+L
Sbjct: 1391 EEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQEL 1429
Score = 56.2 bits (134), Expect = 2e-07
Identities = 79/411 (19%), Positives = 171/411 (41%), Gaps = 64/411 (15%)
Query: 668 YYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
Y + + R+ L ++ EE L E+EA+L E R QQ++ +++K
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG---------------QQLQAERKK 947
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
+ +++ + RQ+ + + + ++ LE + M+ L E LL
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE--RKLL- 1004
Query: 788 QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYL--NENLRKRLDQVEQ 845
++R+ L + + +++ + L + K E +I+ +E L E R+ L+++++
Sbjct: 1005 ------EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 846 ELN-------------ELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEA 892
+L + + E L EL+A R+ D +A+ + I + E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 893 GIKELQKSM----------ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
I +LQ+ + E+ K E ++A+ + ++ T Q L K+E+ +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+++ +L +E T S + +++ Q K++ ++ +Q F K L K
Sbjct: 1179 LKK--ALDEE------TRSHEAQVQEMRQ------KHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKA 1053
++ L++ + + VL K E ++ K++ E+ K G +A
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQE-VEHKKKKLEAQVQELQSKCSDGERA 1274
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/113 (19%), Positives = 49/113 (43%), Gaps = 15/113 (13%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY 228
++ E + K + K +K+ E+L +E+ E+ KE+ +
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG--------------- 1875
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKI 281
N + + + +L+E + + R+L+ +A + E + R+V LK+K+
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 117 bits (292), Expect = 9e-26
Identities = 214/1039 (20%), Positives = 427/1039 (41%), Gaps = 150/1039 (14%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQEL 232
E+ ++ MKE G+ I E L+ E R LEE+ L Q +K L+ L
Sbjct: 848 EKEMATMKEEFGR---IKETLEKSEARRKELEEKMVSLLQ----EKNDLQLQVQAEQDNL 900
Query: 233 NETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLS 292
N+ + D+L + K +++ + +D + ++ + R+L+ + S +K++ + L
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE 960
Query: 293 AERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN 352
+ K++ E K K+L +E+AG E +L KE++ L E ++ +L E K N
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020
Query: 353 SV---KEKEERGI----ARLAQATQERTDL-YAKQGRGSQFTSKEERDKWIKKELKSLDQ 404
S+ K K E+ + L Q + R DL AK+ +E ++ + L++
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 405 AINDKKRQIAAIHKDLEDTEA-------NKEKNLEQYNKLDQDL---NEVKARVE----E 450
+ K+ I + +ED + ++N + +L+++L +A+VE +
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 451 LDRKYYEVKNKKDE------LQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKA 504
L R+ E+ + +E +Q E N ++ AE Q + E+ + + AA K
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMN---KKREAEFQKMRRDLEEATLQHEATAAALRKK 1197
Query: 505 ILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAG-NRLFYHIV 563
+ + + + +D+ +R + Q ++ + F+ E +VT+ ++
Sbjct: 1198 HADSVAELGEQIDNLQR--VKQKLEK-----EKSEFKLE-----LDDVTSNMEQIIKAKA 1245
Query: 564 DSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAI--------PMIS---- 611
+ ++VS + + N+ + E LN + N + +IS
Sbjct: 1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 612 -KLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGA------- 663
KL Y + + + + + ++ + Q AR DC L A
Sbjct: 1306 GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR---HDCDLLREQYEEETEAKAELQRV 1362
Query: 664 LTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE-----------------NLRRNIER 706
L+ + + R + + D + EEL E + KL + +L + R
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 707 INNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRS 759
+ NEI+ LM +++ ++ +QR F D IL+E K E+ Q ++ + RS
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNF----DKILAEWKQKYEESQSELESSQKEARS 1478
Query: 760 L--------QSLEASLHAMESTR---ESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQ 808
L + E SL +E+ + ++L+ E+ +DL QL E K V L +QL+
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEI-SDLTEQLG-EGGKNVHELEKVRKQLE 1536
Query: 809 QENRQLLNERIKL-------EGIITRVETYLNE---NLRKRLDQVEQELNELRETEGGTV 858
E +L + + EG I R + N+ + ++L + ++E+ + + V
Sbjct: 1537 VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Query: 859 LTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIK-------ELQKSMERWKNMEKEH 911
+ TS L+A + + + + ++ +++ E + E QK ++ +++ K+
Sbjct: 1597 DSLQTS-LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1655
Query: 912 M----DAI--NHDTKELEKMTNRQGMLLKKKEECMKKI-----RELGSLPQEAFEKYQTL 960
DA+ N D KE + R+ LL+ + E ++ + R QE E + +
Sbjct: 1656 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1715
Query: 961 SL-----KQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIM 1015
L L + ++ ++L + ++A+ + N E+ +K I + K
Sbjct: 1716 QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1775
Query: 1016 ELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSG 1075
+ LE R + ++ T K + E Q + GGK L + V + + E E
Sbjct: 1776 DTSAHLE-RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKR 1834
Query: 1076 ESERGSGSQSSVPSVDQFT 1094
+E G + S + + T
Sbjct: 1835 NAESVKGMRKSERRIKELT 1853
Score = 110 bits (275), Expect = 8e-24
Identities = 219/1002 (21%), Positives = 416/1002 (41%), Gaps = 175/1002 (17%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEE-------RLHTLEEEKEELAQ--------Y 213
+ER ++ I + E K +++NE L+ EE + LE+E EL +
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTL 963
Query: 214 QKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQ 273
K +K + A E + N L E A LDE+ AK ++ + L++A Q A D ++ E +
Sbjct: 964 AKVEKEKHATENKVKN--LTEEMAGLDEIIAKLT---KEKKALQEAHQQALDDLQVEEDK 1018
Query: 274 VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
V L ++++ + L +++ K R LE + L+ +L E L ++ +L
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 334 LEKIEEK---------------------QKELAETEPKFNSVKEKEERGIARLAQATQER 372
EK+++K QK+L E + + ++E+ E A+ + R
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 373 TDL------------YAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHK-- 418
+DL A Q ++R+ +K + L++A + AA+ K
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198
Query: 419 ------------------------------DLEDTEANKEK------NLEQYNK-LDQDL 441
+L+D +N E+ NLE+ ++ L+
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAA-----------KREDL 490
NE + ++EE R + ++ +LQ+E L R+ E++AL + + EDL
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE-EKEALISQLTRGKLSYTQQMEDL 1317
Query: 491 EKKQQLLRAATGK-AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTC 549
K+QL K A+ + + S D R + + V++ E A +
Sbjct: 1318 --KRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
Query: 550 VEVT-----------AGNRLFYHIVDSDEVSTKI-----LMEFNKMNLPGEVTFLPLNKL 593
T A +L + D++E + +E K L E+ L +
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MV 1432
Query: 594 DVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRS-MEVSTQLARAFTMDCIT 652
DV +N A + K + N FDK K +S +E S + AR+ + +
Sbjct: 1433 DVE-----RSNAAAAALDKKQRN--FDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1485
Query: 653 LEG---DQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLN--ENLRRNIERI 707
L+ + + H ++ LQ+++ E+LGE ++ E +R+ +E
Sbjct: 1486 LKNAYEESLEHLETF-------KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 708 NNEIDQLMNQMQ-QIETQQRKFKASR---DSILSEM-KMLKEKRQQSEKTFMPKQRSLQS 762
E+ + + + +E ++ K ++ + I +E+ + L EK ++ E+ QR + S
Sbjct: 1539 KLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598
Query: 763 LEASLHAMESTRES---LKAELGTDLLS-QLSLEDQKRVDALNDEIRQLQQENRQLLNER 818
L+ SL A +R +K ++ DL ++ L R+ A + +Q++ L + +
Sbjct: 1599 LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA--EAQKQVKSLQSLLKDTQ 1656
Query: 819 IKLEGIITRVETYLNENL---RKRLDQVEQELNELRETEGGTVLTATTSELEAI--NKRV 873
I+L+ + R L EN+ +R + ++ EL ELR T + +E E I ++RV
Sbjct: 1657 IQLDDAV-RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1715
Query: 874 KDTMARSEDLDNSIDKTEAGIKELQKSME----RWKNMEKEHMDAINHD---TKELEKMT 926
+ +++ L N K E+ + +LQ +E +N E++ AI +EL+K
Sbjct: 1716 QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1775
Query: 927 NRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKA 986
+ L + K+ + I++L EA E+ K+ +KLE EL+ +K
Sbjct: 1776 DTSAHLERMKKNMEQTIKDLQHRLDEA-EQIALKGGKKQLQKLEARVRELEGELEAEQKR 1834
Query: 987 LDQFVNFSEQKEKLIK----RQEELDRGYKSIMELMNVLELR 1024
+ V + E+ IK + EE + + +L++ L+L+
Sbjct: 1835 NAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Score = 89.0 bits (219), Expect = 3e-17
Identities = 155/753 (20%), Positives = 296/753 (39%), Gaps = 102/753 (13%)
Query: 332 KLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEER 391
K L K E +KE+A + +F +KE E+ E R
Sbjct: 839 KPLLKSAETEKEMATMKEEFGRIKETLEK---------------------------SEAR 871
Query: 392 DKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEEL 451
K +++++ SL Q ND + Q+ A +L D E ++ ++ +L+ + E+ R+E+
Sbjct: 872 RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDE 931
Query: 452 DRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDS 511
+ E+ KK +L+ E + L ++ + + LA ++ + ++ T + + G+D
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE--MAGLDE 989
Query: 512 INKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTK 571
I L +K + + Q + + + + V++ + + S E K
Sbjct: 990 IIAKLTK-EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKL---EQQVDDLEGSLEQEKK 1045
Query: 572 ILMEFN--KMNLPGEVTF-------LPLNKLDVRDTAYPETNDAIPMISKLRYNP----R 618
+ M+ K L G++ L +KL + + + D SK+ +
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 619 FDKAFKHVFGKTLICRSMEVSTQLARAFT---MDCITLEGDQVSHRGALTGGYYD----- 670
K K + + + ARA ++ E +++S R GG
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 671 TRKSRLELQKDVRKAEEELGELE---AKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
+K E QK R EE + E A L + ++ + +ID L Q++E ++ +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQR-------SLQSLEASLHAMESTRESLKAE 780
FK D + S M+ + + + EK + L+ + SL+ + R L+ E
Sbjct: 1226 FKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285
Query: 781 LG---------TDLLSQLSLEDQKRVDALNDEIRQLQQENR---------QLLNERIKLE 822
G L+SQL+ + D RQL++E + Q L
Sbjct: 1286 NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLL 1345
Query: 823 GIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSED 882
ET L++ L + E+ + R T+ T T ELE K++ R +D
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQWR-TKYETDAIQRTEELEEAKKKLAQ---RLQD 1401
Query: 883 LDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
+ +++ A L+K+ R +N ++ M + + +N L KK+ K
Sbjct: 1402 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV--------ERSNAAAAALDKKQRNFDK 1453
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQ----KE 998
I L Q+ E L Q ++ +TEL K + +++L+ F + +E
Sbjct: 1454 I--LAEWKQKYEESQSELESSQ--KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1509
Query: 999 KLIKRQEELDRGYKSIMELMNVLELRKYEAIQL 1031
++ E+L G K++ EL V + + E ++L
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Score = 82.8 bits (203), Expect = 2e-15
Identities = 169/906 (18%), Positives = 368/906 (40%), Gaps = 156/906 (17%)
Query: 140 KQGKINQMATAPDSQR---LKLLREVAGTRVYDERKEESISLMKETEGKREKI-NELLKY 195
K+ INQ + + ++ L+L +++ + E EE + + K EK+ ++L +
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 196 IEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQ 255
+EE LEE + + +K R A E + R L+E + + E + R+
Sbjct: 1145 LEEISERLEEAGGATSVQIEMNKKREA--------EFQKMRRDLEEATLQHEATAAALRK 1196
Query: 256 LR-DAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQD 314
D+ + +++++++R ++L+ + S K E + +++ ++ IK + LE ++ L+D
Sbjct: 1197 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256
Query: 315 E--------------LAGNSEQRKRLLKERQKLLEKIEEKQK--------ELAETEPKFN 352
+ L + QR +L E +L ++EEK+ +L+ T+ +
Sbjct: 1257 QANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 353 SVKEKEERGIAR--LAQATQ--------------ERTDLYAK-------------QGRGS 383
++ EE G A+ LA A Q E T+ A+ Q R
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
T +R + +++ K L Q + D + + A++ E K + + L D+
Sbjct: 1377 YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGK 503
A LD+K + D++ +E W+++ E Q+ +LE Q+ R+ + +
Sbjct: 1437 SNAAAAALDKK----QRNFDKILAE----WKQKYEESQS------ELESSQKEARSLSTE 1482
Query: 504 A--ILNGIDSINKVLDHFRR--KGINQHV-----QNGYHGIVMNNFECEPAFYTCVEVTA 554
+ N + + L+ F+R K + + + Q G G ++ E ++
Sbjct: 1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 555 GNRLFYHIVDSDEVSTKIL---MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMIS 611
+ L + KIL +EFN++ E KL +D + +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------RKLAEKDEEMEQ--------A 1588
Query: 612 KLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDT 671
K + D + +T RS ++ + D +E Q+SH +
Sbjct: 1589 KRNHQRVVDSLQTSLDAET---RSRNEVLRVKKKMEGDLNEME-IQLSHANRMAA----- 1639
Query: 672 RKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
E QK V+ + L + + +L++ +R N D L + +E + +A
Sbjct: 1640 -----EAQKQVKSLQSLLKDTQIQLDDAVRAN--------DDLKENIAIVERRNNLLQAE 1686
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSL 791
+ + + ++ + R+ +E+ + +Q L + ++ + ++ ++++L T L S++
Sbjct: 1687 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL-TQLQSEVEE 1745
Query: 792 E-------DQKRVDALND------EIRQLQQENRQLLNERIKLEGIITRVETYLNE---- 834
++K A+ D E+++ Q + L + +E I ++ L+E
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805
Query: 835 ---NLRKRLDQVEQELNELR-ETEGGTVLTATTSE-LEAINKRVKDTMARSED------- 882
+K+L ++E + EL E E A + + + +R+K+ ++E+
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
Query: 883 LDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
L + +DK + +K ++ E + ++ EL++ R + + + K
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Query: 943 IRELGS 948
R++G+
Sbjct: 1926 SRDIGA 1931
Score = 68.2 bits (165), Expect = 5e-11
Identities = 157/829 (18%), Positives = 323/829 (38%), Gaps = 143/829 (17%)
Query: 266 KMEDIERQVRELKTKISAMKEEKEQLSAERQEQ-------IKQRTKLELKAKDLQDELAG 318
K + E+++ +K + +KE E+ A R+E ++++ L+L+ + QD L
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 319 NSEQRKRLLKERQKLLEKIEEKQKELAETE---PKFNSVKEKEERGIARLAQATQERTDL 375
E+ +L+K + +L K++E + L + E + + K K E + L + +
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQAI----NDKKRQIAAIHKDLEDTEANKEK-- 429
AK + T E + K + +E+ LD+ I +KK A + L+D + ++K
Sbjct: 963 LAKVEKEKHAT--ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020
Query: 430 ------------------NLEQYNKLDQDLNEVKARVE-------------ELDRKYYEV 458
+LEQ K+ DL K ++E E D+ E
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 459 KNKKDELQSERNYLWREENAEQQALA-----------AKREDLEKKQQLLRAATGKAILN 507
K KK E + + ++Q LA A+ E+LE++ + R A K
Sbjct: 1081 KLKKKEFDINQQ---NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK---- 1133
Query: 508 GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDE 567
+ K+ R +++ ++ + E E T V++ + +
Sbjct: 1134 ----VEKL-----RSDLSRELEE-----ISERLE-EAGGATSVQIEMNKK-------REA 1171
Query: 568 VSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKA-FKHV 626
K+ + + L E T L K A E + I + +++ +K+ FK
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVA--ELGEQIDNLQRVKQKLEKEKSEFKLE 1229
Query: 627 FGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGAL---TGGYYDTRKSRLELQKDVR 683
+ +ME + TLE +R L D R +LQ +
Sbjct: 1230 LDD--VTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENG 1287
Query: 684 KAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK 743
+ +L E EA +++ L R +++ L Q+++ + + S + +L+
Sbjct: 1288 ELARQLEEKEALISQ-LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 744 EKRQQSEKTFMPKQRSLQSLEASL------HAMESTRESLKAELGTDLLSQLSLEDQKRV 797
E+ ++ + QR L + + + ++ + + + E L+Q + ++ V
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Query: 798 DALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGT 857
+A+N + L++ +L NE +E ++ VE + LD+ ++ +++ E
Sbjct: 1407 EAVNAKCSSLEKTKHRLQNE---IEDLMVDVER--SNAAAAALDKKQRNFDKIL-AEWKQ 1460
Query: 858 VLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINH 917
+ SELE+ K + L N+ +++ EH++
Sbjct: 1461 KYEESQSELESSQKEARSLSTELFKLKNAYEES------------------LEHLETFKR 1502
Query: 918 DTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELK 977
+ K L++ + L ++ E K + EL E K + +L LE+ L+
Sbjct: 1503 ENKNLQEEISD---LTEQLGEGGKNVHEL-----EKVRKQLEVEKLELQSALEEAEASLE 1554
Query: 978 KYSHVNKKALDQFVNFSEQK----EKLIKRQEELDRGYKSIMELMNVLE 1022
H K L + F++ K KL ++ EE+++ ++ +++ L+
Sbjct: 1555 ---HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQ 1600
Score = 64.7 bits (156), Expect = 5e-10
Identities = 101/544 (18%), Positives = 224/544 (41%), Gaps = 70/544 (12%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFK 729
D + EL RK E+E EL+ +++ L + ++ E N+++ + +
Sbjct: 930 DEEEMNAELTAKKRKLEDECSELKKDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLD 988
Query: 730 ASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQL 789
+ E K L+E QQ+ ++ + SL S +E + L+ L + ++
Sbjct: 989 EIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM 1048
Query: 790 SLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNE 849
LE KR L +++ Q+ L N++++LE E L+K+ + Q+ ++
Sbjct: 1049 DLERAKR--KLEGDLKLTQESIMDLENDKLQLE-----------EKLKKKEFDINQQNSK 1095
Query: 850 LRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEK 909
+ + + VL + K++K+ AR E+L+ ++ + +E+ ++
Sbjct: 1096 IEDEQ---VLALQ------LQKKLKENQARIEELEEELEAERTA----RAKVEKLRSDLS 1142
Query: 910 EHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIR---ELGSLPQEA----FEKYQTLSL 962
++ I+ +E T+ Q + KK+E +K+R E +L EA K S+
Sbjct: 1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1202
Query: 963 KQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLE 1022
+L +++ +K + + + + E++IK + L++ +++ + N
Sbjct: 1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR 1262
Query: 1023 LRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSG 1082
++ EA ++ ++ + +A L + G++ + E S + RG
Sbjct: 1263 VKLEEA--------QRSLNDFTTQ-----RAKLQTENGELARQLEEKEALIS-QLTRG-- 1306
Query: 1083 SQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLF 1142
++S+T + +++ + G K+ +A AL A CD
Sbjct: 1307 ----------------KLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYE 1350
Query: 1143 DEIDQALDAQHRKAVSDMIMELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDV 1200
+E + + Q + +S E+A ++ T R E LE A K + ++ ++
Sbjct: 1351 EETEAKAELQ--RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 1201 ITAE 1204
+ A+
Sbjct: 1409 VNAK 1412
Score = 39.3 bits (90), Expect = 0.023
Identities = 46/208 (22%), Positives = 85/208 (40%), Gaps = 7/208 (3%)
Query: 863 TSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKEL 922
++E E +K+ R ++ +++K+EA KEL++ M + + + + L
Sbjct: 844 SAETEKEMATMKEEFGRIKE---TLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 923 EKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHV 982
R L+K K + K++E+ ++ E L+ K+ RKLE +ELKK
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK--RKLEDECSELKKDIDD 958
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ L + E +K E G I+ + + EA Q + +
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 1043 VFQKLVPGGKATLVMKKGDVEGSQSQDE 1070
V + K L + D+EGS Q++
Sbjct: 1019 V--NSLSKSKVKLEQQVDDLEGSLEQEK 1044
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 115 bits (289), Expect = 2e-25
Identities = 213/1039 (20%), Positives = 433/1039 (41%), Gaps = 181/1039 (17%)
Query: 160 REVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKM 219
+E+A + E+ +E ++ +TE KR K +EE++ TL +EK +L
Sbjct: 851 KEMANMKEEFEKTKEELA---KTEAKR-------KELEEKMVTLMQEKNDLQ-------- 892
Query: 220 RRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKT 279
L+ L + + D+L + K +++ + +D + ++ + R+L+
Sbjct: 893 ---LQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 949
Query: 280 KISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE 339
+ S +K++ + L + K++ E K K+L +E+AG E +L KE++ L E ++
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 340 KQKELAETEPKFNSV---KEKEERGI----ARLAQATQERTDL-YAKQGRGSQFTSKEER 391
+L E K N++ K K E+ + L Q + R DL AK+ +E
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 392 DKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEEL 451
I+ + + LD+ + K+ +++ + +ED +A +L + + E++AR+EEL
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQA-------LGMQLQKKIKELQARIEEL 1122
Query: 452 DRKYYEVKNKKDELQSERNYLWRE------------------------ENAEQQALAAKR 487
+ + + + + + +R+ L RE AE Q +
Sbjct: 1123 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 488 EDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFY 547
E+ + + A K + + + + +D+ +R + Q ++ + M +
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDLASNME 1240
Query: 548 TCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYP-ETNDA 606
T V GN D++S E + L ++T +L Y + ++
Sbjct: 1241 T-VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT-AQRARLQTESGEYSRQLDEK 1298
Query: 607 IPMISKL-RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM---DCITL----EGDQV 658
++S+L R F + + + K + ++ + LA A DC L E +Q
Sbjct: 1299 DTLVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQE 1356
Query: 659 SH---RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE----------------- 698
+ + A++ + + R + + D + EEL E + KL +
Sbjct: 1357 AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 1416
Query: 699 NLRRNIERINNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKM---------- 741
+L + +R+ NE++ LM +++ ++ +QR F D IL+E K
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF----DKILAEWKQKCEETHAELE 1472
Query: 742 --LKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
KE R S + F K +SL+ L ++ ++L+ E+ +DL Q++ E KR+
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLD-QLETLKRENKNLQQEI-SDLTEQIA-EGGKRIHE 1529
Query: 800 LNDEIRQLQQENRQL---LNERIKL----EGIITRVETYLNE---NLRKRLDQVEQELNE 849
L +Q++QE +L L E EG I R++ LN+ + +++ + ++E+++
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1589
Query: 850 LRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQK----SMERWK 905
++ ++ + S L+A + D + + ++ +++ E + + ++ ++
Sbjct: 1590 MKRNH-IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 906 NME------KEHMD---AINHDTKELEKMTNRQGMLLK----------KKEECMKKIREL 946
N + + H+D D KE M R+ LL+ ++ E +KI E
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 947 GSLPQEAFEKYQTL----------------SLKQLFRKLEQCNTELKKYSHVNKKALDQF 990
L +A E+ Q L + Q+ ++E E + KKA+
Sbjct: 1709 ELL--DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766
Query: 991 VNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPG 1050
+E+ +K L+R K++ + + L+ R EA QL K K QKL
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ----IQKL--- 1819
Query: 1051 GKATLVMKKGDVEGSQSQD 1069
+A + +G+VE Q ++
Sbjct: 1820 -EARVRELEGEVESEQKRN 1837
Score = 112 bits (280), Expect = 2e-24
Identities = 211/982 (21%), Positives = 432/982 (43%), Gaps = 139/982 (14%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESIS-LMKETEGKREKINELLKYI---EE 198
K+ + A +++ L E+AG +E+I+ L KE + +E + L + E+
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGL-------DETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 199 RLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSG------EK 252
+++TL + K +L Q + D + +LE E + ++D AKR+ G E
Sbjct: 1020 KVNTLTKAKIKLEQ--QVDDLEGSLE--------QEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 253 SRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDL 312
+ + + +Q +K++ E ++ L++KI E+++ L + Q++IK+ L+ + ++L
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKI----EDEQALGMQLQKKIKE---LQARIEEL 1122
Query: 313 QDELAGNSEQRKRLLKERQKLLEKIEEKQKELAE------TEPKFNSVKEKEERGIAR-L 365
++E+ R + K+R L ++EE + L E + + N +E E + + R L
Sbjct: 1123 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 366 AQAT--QERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDT 423
+AT E T ++ E+ +++ + L++ ++ K +I + ++E T
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNME-T 1241
Query: 424 EANKEKNLEQY-NKLDQDLNEVKARVEELDRKYYEVKNKKDELQS----------ERNYL 472
+ + NLE+ L+ L+E+K + EE R ++ ++ LQ+ E++ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 473 WREENAEQQALAAKREDLEKKQQLLRAATGK-AILNGIDSINKVLDHFRRKGINQHVQNG 531
+ + +QA + E+L K+QL K A+ + + S D R + +
Sbjct: 1302 VSQLSRGKQAFTQQIEEL--KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 532 YHGIVMNNFECEPAFYTCVEVT-----------AGNRLFYHIVDSDE----VSTKIL-ME 575
M+ E A + T A +L + D++E V+ K +E
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE 1419
Query: 576 FNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRS 635
K L EV L +DV TN A + K + N FDK K +
Sbjct: 1420 KTKQRLQNEVEDL---MIDVE-----RTNAACAALDKKQRN--FDKILAEWKQKCEETHA 1469
Query: 636 -MEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRKAEEELGELE 693
+E S + +R+ + + ++ Y+ +LE L+++ + ++E+ +L
Sbjct: 1470 ELEASQKESRSLSTELFKIK------------NAYEESLDQLETLKRENKNLQQEISDLT 1517
Query: 694 AKLNENLRR--NIERINNEIDQLMNQMQ-QIETQQRKFKASRDSILSEMKMLKEKRQQSE 750
++ E +R +E+I +++Q +++Q +E + + IL L + + + +
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577
Query: 751 KTFMPKQRSLQSLEAS-LHAMESTRESLKAELGTDLLSQLSLEDQKRVDA-LNDEIRQLQ 808
+ K + ++ + + +ES + +L AE+ + ++ +K+++ LN+ QL
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS---RNDAIRLKKKMEGDLNEMEIQLN 1634
Query: 809 QENR---QLLNERIKLEGIITRVETYLNENLRKRLDQVEQ-------------ELNELRE 852
NR + L + I+ + +L++ LR + D EQ E+ ELR
Sbjct: 1635 HANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1694
Query: 853 TEGGTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGIKELQKSME----RWKN 906
T T + +E E + ++RV+ ++ L N+ K E I ++Q ME +N
Sbjct: 1695 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARN 1754
Query: 907 MEKEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLK 963
E++ AI +EL+K + L + K+ + +++L EA E+ K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-EQLALKGGK 1813
Query: 964 QLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR---QEELDRGYKSIMELMNV 1020
+ +KLE EL+ +K + V + E+ +K Q E DR K+I+ L ++
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR--KNILRLQDL 1871
Query: 1021 LELRKYEAIQLTFKQVSKNFSE 1042
++ K +A ++K+ ++ E
Sbjct: 1872 VD--KLQAKVKSYKRQAEEAEE 1891
Score = 87.8 bits (216), Expect = 6e-17
Identities = 193/978 (19%), Positives = 400/978 (40%), Gaps = 174/978 (17%)
Query: 196 IEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQ 255
I+ L + E EKE ++++K + +EL +T AK EL K T ++
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTK---------EELAKTEAKRKELEEKMVTLMQEKN- 889
Query: 256 LRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDE 315
D++ QV+ ++ +E +QL IK + +LE K K++ +
Sbjct: 890 -------------DLQLQVQAEADSLADAEERCDQL-------IKTKIQLEAKIKEVTER 929
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAE--------------TEPKFNSVKEKEERG 361
E L +++KL ++ E +K++ + TE K ++ E+
Sbjct: 930 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
Query: 362 IARLAQATQERTDLY-AKQGRGSQFTSKEERDKWIKKELKSLDQAINDKK---RQIAAIH 417
+A+ T+E+ L A Q ++E++ + K L+Q ++D + Q I
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR 1049
Query: 418 KDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE-LDRKYYEVKNKKDELQSERNYLWREE 476
DLE + E +L+ + D+ K +++E L +K +E+ + +++ E+ L +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ-ALGMQL 1108
Query: 477 NAEQQALAAKREDLEKKQQLLRAATGKA------ILNGIDSINKVLDHFRRKGINQHVQN 530
+ + L A+ E+LE++ + RA+ KA + ++ I++ L+ Q N
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168
Query: 531 GYHGIVMNNFECEPAFYTCV-EVTAGNRLFYHIVDSDEVSTKI-LMEFNKMNLPGEVTFL 588
+ T E TA H E+ +I ++ K L E + +
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1228
Query: 589 PLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM 648
K+++ D A + +SK + N +K +CR++E +
Sbjct: 1229 ---KMEIDDLA-----SNMETVSKAKGN--LEK----------MCRALEDQLSEIKTKEE 1268
Query: 649 DCITLEGDQVSHRGAL--TGGYYDTR---KSRL--ELQKDVRKAEEELGELEAKLNENLR 701
+ L D + R L G Y + K L +L + + +++ EL+ +L E ++
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328
Query: 702 RN------IERINNEIDQLMNQMQQ-----IETQQRKFKASRD----------SILSEMK 740
++ ++ D L Q ++ E Q+ KA+ + + +
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 741 MLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLL-------------- 786
L+E +++ + + ++++ A ++E T++ L+ E+ DL+
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV-EDLMIDVERTNAACAALD 1447
Query: 787 ------SQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL 840
++ E +++ + + E+ Q+E+R L E K++ L E L++
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL-ETLKREN 1506
Query: 841 DQVEQELNELRE--TEGGTVLTATTSELEAINKRVK----DTMARSEDLDNSIDKTEAGI 894
++QE+++L E EGG + ELE I K+V+ + A E+ + S++ E I
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRI----HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
Query: 895 KELQKSMERWKNMEKEHMD-AINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEA 953
+Q + N K +D I +E+++M +++ + +L E
Sbjct: 1563 LRIQLEL----NQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQ---------STLDAEI 1609
Query: 954 FEKYQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQFVNFSEQKEKLIKRQEELD---R 1009
+ + LK +K+E E++ + +H N+ A + N+ + L Q LD R
Sbjct: 1610 RSRNDAIRLK---KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 1010 GYKSIMELMNVLELR------KYEAIQLTFKQVSKNFSEVFQKLVPGGK---------AT 1054
+ + E + ++E R + E ++ T +Q ++ Q+L+ + +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 1055 LVMKKGDVEGSQSQDEGE 1072
L+ K +E SQ +GE
Sbjct: 1727 LINTKKKLETDISQIQGE 1744
Score = 83.6 bits (205), Expect = 1e-15
Identities = 155/873 (17%), Positives = 342/873 (39%), Gaps = 129/873 (14%)
Query: 156 LKLLREVAGTRVYDERKEESISLMKETEGKREK----INELLKYIEERLHT--------L 203
++L +++ + E EE I + + K EK ++ L+ I ERL +
Sbjct: 1106 MQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 204 EEEKEELAQYQKWDKMRRALEYTIYNQELN-------------ETRAKLDELSAKRETSG 250
E K+ A++QK MRR LE E E ++D L ++
Sbjct: 1166 EMNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 251 EKSRQLRDAQQDARDKME-------DIERQVRELKTKISAMKEEKEQLSAERQEQIKQRT 303
++ +++ D ME ++E+ R L+ ++S +K ++E+ + QR
Sbjct: 1223 KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRA 1282
Query: 304 KLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVK-------- 355
+L+ ++ + +L +L + +Q ++IEE +++L E E K S
Sbjct: 1283 RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE-EIKAKSALAHALQSSR 1341
Query: 356 ----------EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQA 405
E+E+ A L +A + A Q R T +R + +++ K L Q
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRAMSKANSEVA-QWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 406 INDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDEL 465
+ D + + A++ E K++ + L D+ A LD+K + D++
Sbjct: 1401 LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK----QRNFDKI 1456
Query: 466 QSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGIN 525
+E E +AE + A+++E +L + I N + L+ +R+ N
Sbjct: 1457 LAEWKQKCEETHAELE--ASQKESRSLSTELFK------IKNAYEESLDQLETLKRE--N 1506
Query: 526 QHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLP--- 582
+++Q + E + ++ V+ ++ + +E + +L
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQ-------VEQEKSELQAALEEAEASLEHEE 1559
Query: 583 GEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQL 642
G++ + L V+ + + I +++ N H+ I SM+ +
Sbjct: 1560 GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN--------HI----RIVESMQSTLDA 1607
Query: 643 ARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRR 702
D I L+ + + E ++ R + L + + L++ LR
Sbjct: 1608 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRS 1667
Query: 703 NIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
+ L Q+ +E + +A + + + ++ + R+ +E+ + +Q
Sbjct: 1668 Q--------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1719
Query: 763 LEASLHAMESTRESLKAELGT------DLLSQLSLEDQKRVDALND------EIRQLQQE 810
L ++ +T++ L+ ++ D++ + ++K A+ D E+++ Q
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 811 NRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNEL----RETEGGTVLTATTSEL 866
+ L + LE + ++ L+E + L ++++ +L RE EG V + +
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG-EVESEQKRNV 1838
Query: 867 EAIN------KRVKDTMARSED-------LDNSIDKTEAGIKELQKSMERWKNMEKEHMD 913
EA+ ++VK+ ++E+ L + +DK +A +K ++ E + ++
Sbjct: 1839 EAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLS 1898
Query: 914 AINHDTKELEKMTNRQGMLLKKKEECMKKIREL 946
ELE+ R + + + K RE+
Sbjct: 1899 KFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 67.4 bits (163), Expect = 8e-11
Identities = 90/366 (24%), Positives = 162/366 (44%), Gaps = 57/366 (15%)
Query: 108 QYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRV 167
Q LD ++ ++ND + L + +G +N+M +L +A +
Sbjct: 1602 QSTLDAEIRSRNDAIRLKKKM------------EGDLNEMEI-----QLNHANRMAAEAL 1644
Query: 168 YDERKEESISLMKETE-------GKREKINELLKYIEERLHTLEEEKEEL-AQYQKWDKM 219
+ R ++I +K+T+ +E + E L +E R + L+ E EEL A ++ ++
Sbjct: 1645 RNYRNTQAI--LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1702
Query: 220 RRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKT 279
R+ E QEL + ++ L + + ++L + +MEDI ++ R +
Sbjct: 1703 RKIAE-----QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE 1757
Query: 280 KI-------SAMKEE--KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKER 330
K + M EE KEQ ++ E++K+ LE KDLQ L E + LK
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKN--LEQTVKDLQHRL---DEAEQLALKGG 1812
Query: 331 QKLLEKIEEKQKEL---AETEPKFN--SVK--EKEERGIARLAQATQE-RTDLYAKQGRG 382
+K ++K+E + +EL E+E K N +VK K ER + L T+E R ++ Q
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLV 1872
Query: 383 SQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLN 442
+ +K K K++ + ++ N + I +LE+ E + Q NKL
Sbjct: 1873 DKLQAKV---KSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSR 1929
Query: 443 EVKARV 448
EV ++
Sbjct: 1930 EVHTKI 1935
Score = 67.0 bits (162), Expect = 1e-10
Identities = 118/586 (20%), Positives = 246/586 (41%), Gaps = 66/586 (11%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAK---LNENLRRNIERINN----------------- 709
+T K ++++ K +EEL + EAK L E + ++ N+
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 710 EIDQLMNQMQQIETQQRKFKASRD-------SILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
DQL+ Q+E + ++ + + ++ + L+++ + +K + +L
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 763 LEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQEN---RQLLNE 817
+E HA E+ ++L E+ + +++L+ E + +A + LQ E L
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 818 RIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLT-ATTSELEAINKRVKDT 876
+IKLE + +E L + + R+D + R+ EG L +T ++E +++ +
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAK----RKLEGDLKLAQESTMDIENDKQQLDEK 1083
Query: 877 MARSE----DLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGML 932
+ + E L + I+ +A +LQK ++ + +E + I + K ++ L
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1143
Query: 933 LKKKEECMKKIRELGSLPQEAFE--KYQTLSLKQLFRKLEQCN--------TELKKYSHV 982
++ EE +++ E G E K + +++ R LE+ T KK++
Sbjct: 1144 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ +Q N K+KL K + E+ + M + K ++ + + SE
Sbjct: 1204 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN-LEKMCRALEDQLSE 1262
Query: 1043 VFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSF 1102
+ K + L+ D+ +++ + E SGE R + ++ V Q + + +F
Sbjct: 1263 I--KTKEEEQQRLI---NDLTAQRARLQTE-SGEYSRQLDEKDTL--VSQLSRG--KQAF 1312
Query: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
T + E++ + KS +A AL + CD E +Q A+ ++A+S
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY--EEEQEAKAELQRAMSKANS 1370
Query: 1163 ELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDVITAEMA 1206
E+A ++ T R E LE A K + ++ H++ + A+ A
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 1416
Score = 54.7 bits (130), Expect = 5e-07
Identities = 58/254 (22%), Positives = 112/254 (44%), Gaps = 32/254 (12%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW-----DKMRRALEYTI 227
EE + +++TE R+ + L ER+ L + L +K +++ +E I
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 228 YNQELNETRAK---------LDELSAKRETSGEKSRQLRDAQQDARD---KMEDIE---- 271
E +AK +EL +++TS R ++ +Q +D ++++ E
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Query: 272 ----RQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLL 327
+Q+++L+ ++ ++ E E E +K K E K K+L + E RK +L
Sbjct: 1810 KGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ---TEEDRKNIL 1866
Query: 328 KERQKLLEKIEEKQKEL---AETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQ 384
+ Q L++K++ K K AE + ++V + R I + +ER D+ Q +
Sbjct: 1867 R-LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
Query: 385 FTSKEERDKWIKKE 398
S+E K I +E
Sbjct: 1926 VKSREVHTKIISEE 1939
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 115 bits (287), Expect = 3e-25
Identities = 181/941 (19%), Positives = 377/941 (40%), Gaps = 116/941 (12%)
Query: 170 ERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYN 229
ER E+ + E K+ K+ + +++ + LE K +K + A E + N
Sbjct: 925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE------LTLAKVEKEKHATENKVKN 978
Query: 230 QELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKE 289
L E + LDE AK + + L++A Q A D ++ E +V L S ++++ E
Sbjct: 979 --LTEELSGLDETIAKLT---REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE 1033
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEK--------- 340
L + +++ K R LE + L+ +L E L ++Q+L E++++K
Sbjct: 1034 DLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS 1093
Query: 341 ------------QKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGR------- 381
QK++ E + + ++E+ E A A+ ++R+D YA++
Sbjct: 1094 KVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD-YARELEELSERLE 1152
Query: 382 ------GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYN 435
+Q ++R+ K + L++A + +AA+ K D+ A + ++
Sbjct: 1153 EAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ 1212
Query: 436 ----KLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLE 491
KL+++ +E K +++L V K L+ L E Q A+ ++ E
Sbjct: 1213 RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL------EDQLSEARGKNEE 1266
Query: 492 KKQQLLRAATGKAILNG-IDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCV 550
++ L T K+ L +++ L+ ++ I + E +
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEE--KESIVSQLSRSKQAFTQQTEELKRQLE--- 1321
Query: 551 EVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTF---LPLNKLDVRDTAYPETNDAI 607
E H + S +L E + G+ L +V DAI
Sbjct: 1322 EENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI 1381
Query: 608 PMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGG 667
+L K + + ++ S + A C +LE + +G +
Sbjct: 1382 QRTEELEE------------AKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429
Query: 668 YYDTRKSR---LELQKDVR-----------KAEEELGELEAKLNEN--LRRNIERINNEI 711
D ++ L K R K EE ELEA L E+ L + ++ N
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Query: 712 DQLMNQMQQIETQQRKFKASRDSILSEMKM-------LKEKRQQSEKTFMPKQRSLQSLE 764
++ ++Q++ ++ + + + + ++ L++ R+Q E Q +L+ E
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE 1549
Query: 765 ASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGI 824
A+L E+ ++ EL +Q+ E +++ ++EI QL++ ++ + ++
Sbjct: 1550 AALEHEEAKILRIQLEL-----TQVKSEIDRKIAEKDEEIEQLKRNYQRTVET---MQSA 1601
Query: 825 ITRVETYLNENLRKRLDQVEQELNEL--RETEGGTVLTATTSELEAINKRVKDTMARSED 882
+ NE +R + ++E +LNE+ + + T L ++ ++KDT
Sbjct: 1602 LDAEVRSRNEAIRLK-KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH--- 1657
Query: 883 LDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
LD+++ + + +KE +ER N+ + ++ + ++ E+ L E ++
Sbjct: 1658 LDDAL-RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+ + +K +T L QL ++E + + + KKA+ +E+ +K
Sbjct: 1717 LHTQNTSLIHTKKKLET-DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEV 1043
L+R K++ + + L+ R EA QL K K ++
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1816
Score = 104 bits (260), Expect = 4e-22
Identities = 201/1002 (20%), Positives = 427/1002 (42%), Gaps = 124/1002 (12%)
Query: 92 DKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNL-LESAGFSRSNPYYIVKQGKINQMATA 150
D+EE++ +K + D+ K D+ +L L A + K + + +
Sbjct: 929 DEEEINAELTAKKRKLE---DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG 985
Query: 151 PDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL 210
D KL RE + E ++++ ++ E K +N+ +E+++ LE E+
Sbjct: 986 LDETIAKLTRE---KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042
Query: 211 AQYQ-KWDKMRRALEYTIYNQE-----LNETRAKLDELSAKRETSGEKSRQLRDAQQDAR 264
+ + ++ +R LE + + L + +LDE K++ + QL+ +D +
Sbjct: 1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF---EYCQLQSKVEDEQ 1099
Query: 265 DKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDEL--AG---- 318
+++++EL+ +I ++EE E A R + KQR+ + ++L + L AG
Sbjct: 1100 TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 319 -----NSEQRKRLLKERQKLLEKIEEKQKELAETEPKF-NSVKEKEER--GIARLAQATQ 370
N ++ LK R+ L E + + +A K +SV E E+ + R+ Q +
Sbjct: 1160 TQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219
Query: 371 ERTDLYAKQ--GRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE 428
+ + + S S + ++K ++L+ +++ + + I + L + K
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKS 1279
Query: 429 KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKRE 488
+ + +L + L E ++ V +L R + +EL+ + + +NA AL + R
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 489 DLE-KKQQLLRAATGKAIL-NGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAF 546
D + ++Q GKA L + N + +R K +E +
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK-----------------YETDAIQ 1382
Query: 547 YTCVEVTAGNRLFYHIVDSDE----VSTKIL-MEFNKMNLPGEVTFLPLNKLDVRDTAYP 601
T A +L + DS+E V+ K +E K L GEV L +DV
Sbjct: 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL---MVDVE----- 1434
Query: 602 ETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRS-MEVSTQLARAFTMDCITLEGDQVSH 660
N + K + N FDK K ++ +E S + +R+ + + L+
Sbjct: 1435 RANSLAAALDKKQRN--FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLK------ 1486
Query: 661 RGALTGGYYDTRKSRLE-LQKDVRKAEEELGELEAKLNEN---------LRRNIERINNE 710
Y+ +LE ++++ + E+E+ +L ++ EN R+ IE +
Sbjct: 1487 ------NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540
Query: 711 IDQLMNQ----MQQIETQQRKFKASRDSILSEM-KMLKEKRQQSEKTFMPKQRSLQSLEA 765
I + + ++ E + + + + SE+ + + EK ++ E+ QR+++++++
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQS 1600
Query: 766 SLHAMESTRES---LKAELGTDLLS-QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKL 821
+L A +R LK ++ DL ++ L R A + ++ L+ QL + ++ L
Sbjct: 1601 ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAA--ETLKHLRSVQGQLKDTQLHL 1658
Query: 822 EGIITRVETYLNENL---RKRLDQVEQELNELRETEGGTVLTATTSELEAI--NKRVKDT 876
+ + R + L E L +R + ++ E+ ELR T T +E E + N+RV+
Sbjct: 1659 DDAL-RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 877 MARSEDLDNSIDKTEAGIKELQKSME----RWKNMEKEHMDAINHD---TKELEKMTNRQ 929
++ L ++ K E + +LQ +E +N E++ AI +EL+K +
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS 1777
Query: 930 GMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLK-------QLFRKLEQCNTELKKYSHV 982
L + K+ + +++L Q ++ + L+LK +L ++ + EL+
Sbjct: 1778 AHLERMKKNLEQTVKDL----QHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK 1833
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELR 1024
N +++ + + ++L + EE + + +L++ L+++
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875
Score = 100 bits (249), Expect = 8e-21
Identities = 171/898 (19%), Positives = 380/898 (42%), Gaps = 145/898 (16%)
Query: 173 EESISLMKE----TEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY 228
E+ ++ MKE T+ + K K +EE+L TL +EK +L L+
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ-----------LQVQAE 895
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEK 288
++ L + + D+L + K +++ + +D + ++ + R+L+ + S +K++
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 289 EQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE 348
+ L + K++ E K K+L +EL+G E +L +E++ L E ++ +L E
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 349 PKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
K NS+ + + + ++++++ L+ ++
Sbjct: 1016 DKVNSLNKTKSK----------------------------------LEQQVEDLESSLEQ 1041
Query: 409 KKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSE 468
+K+ + ++ E + + E L+ D ++ R+++ D +Y ++++K ++ Q+
Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQT- 1100
Query: 469 RNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHV 528
L + + + L A+ E+LE++ + RA K D ++ + +++ +
Sbjct: 1101 ---LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAREL------EELSERL 1151
Query: 529 QNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFL 588
+ E T ++ + + K+ + + L E
Sbjct: 1152 E-------------EAGGVTSTQIELNKK-------REAEFLKLRRDLEEATLQHEAMVA 1191
Query: 589 PLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKA-FKHVFGKTLICRSMEVSTQLARAFT 647
L K A E + I + +++ +K+ FK + SME ++
Sbjct: 1192 ALRKKHADSVA--ELGEQIDNLQRVKQKLEKEKSEFKLEIDD--LSSSMESVSKSKANLE 1247
Query: 648 MDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE------NLR 701
C TLE DQ+S G + ++S EL + + E GEL +L E L
Sbjct: 1248 KICRTLE-DQLSE---ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 702 RNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQ 761
R+ + + ++L Q+++ + + S + +L+E+ ++ ++ QR+L
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 762 SLEASL------HAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLL 815
+ + + ++ + + + E L+Q + +++V+A+N + L++ ++L
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 816 NERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKD 875
E +E ++ VE +L LD+ ++ +++ E T + +ELEA +K+
Sbjct: 1424 GE---VEDLMVDVER--ANSLAAALDKKQRNFDKVL-AEWKTKCEESQAELEA---SLKE 1474
Query: 876 TMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMD-----AINHDT-KELEKMTNRQ 929
+ + S +L + E + +L+ KN+E+E D A N T ELEK
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKS---- 1530
Query: 930 GMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQ 989
+K+ E K +L EA +++ + ++ +L Q +E+ +
Sbjct: 1531 ----RKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR----------- 1575
Query: 990 FVNFSEQKEKLIKRQEELDRGYKSIMELMNV---LELR-KYEAIQLTFKQVSKNFSEV 1043
+E+ E++ E+L R Y+ +E M E+R + EAI+L K++ + +E+
Sbjct: 1576 --KIAEKDEEI----EQLKRNYQRTVETMQSALDAEVRSRNEAIRLK-KKMEGDLNEI 1626
Score = 97.4 bits (241), Expect = 7e-20
Identities = 159/836 (19%), Positives = 336/836 (40%), Gaps = 93/836 (11%)
Query: 153 SQRLKLLREVAGTRVYDERKEES--ISLMKETEGKREKINELLKYIEER-LHTLEEEKEE 209
S+RL+ V T++ +K E+ + L ++ E + ++ + ++ ++ E E+
Sbjct: 1148 SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207
Query: 210 LAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMED 269
+ Q+ K + E + + E+++ + ++ +S + + R L D +AR K E+
Sbjct: 1208 IDNLQRV-KQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266
Query: 270 IERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKE 329
I+R + EL T+ S ++ E +LS Q++++ + + + +E+ KR L+E
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELS----RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 330 RQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKE 389
K + + E+E+ G A L +A + A Q R T
Sbjct: 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA-QWRTKYETDAI 1381
Query: 390 ERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVE 449
+R + +++ K L Q + D + Q+ A++ E K++ + L D+ +
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA 1441
Query: 450 ELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGI 509
LD+K + D++ +E E AE +A + L + L+ A +A L+ +
Sbjct: 1442 ALDKK----QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA-LDQL 1496
Query: 510 DSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVS 569
+++ + K + Q + + I N T E+ + ++ ++
Sbjct: 1497 ETVKR-----ENKNLEQEIADLTEQIAENG-------KTIHELEKSRKQ----IELEKAD 1540
Query: 570 TKILMEFNKMNLPGE---VTFLPLNKLDVRDTAYPETNDAIPMISKLRYN-PRFDKAFKH 625
++ +E + L E + + L V+ + + I +L+ N R + +
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQS 1600
Query: 626 VFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKA 685
+ RS + +L + D +E Q+SH + E K +R
Sbjct: 1601 ALDAEV--RSRNEAIRLKKKMEGDLNEIE-IQLSH----------ANRQAAETLKHLRSV 1647
Query: 686 EEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEK 745
+ +L + + L++ LR + L Q+ +E + +A + + + ++ +
Sbjct: 1648 QGQLKDTQLHLDDALRGQ--------EDLKEQLAIVERRANLLQAEVEELRATLEQTERA 1699
Query: 746 RQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS-QLSLEDQKRVDALN--- 801
R+ +E+ + +Q L H ++ K +L TDL+ Q +ED R DA N
Sbjct: 1700 RKLAEQELLDSNERVQLL----HTQNTSLIHTKKKLETDLMQLQSEVEDASR-DARNAEE 1754
Query: 802 -------------DEIRQLQQENRQLLNERIKLEGIITRVETYLNE-------NLRKRLD 841
+E+++ Q + L + LE + ++ L+E +K++
Sbjct: 1755 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1814
Query: 842 QVEQELNELR-ETEGGTVL-TATTSELEAINKRVKDTMARSED-------LDNSIDKTEA 892
++E + EL E EG T + L +RVK+ +SE+ L + +DK +
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV 1874
Query: 893 GIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGS 948
+K ++ E H+ ELE+ R + + + K R+ S
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTS 1930
Score = 90.1 bits (222), Expect = 1e-17
Identities = 171/821 (20%), Positives = 337/821 (41%), Gaps = 115/821 (14%)
Query: 332 KLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEER 391
KL KI+ K AETE + ++KE+ ++ LA++ +R +L
Sbjct: 832 KLFFKIKPLLKS-AETEKEMATMKEEFQKTKDELAKSEAKRKEL---------------- 874
Query: 392 DKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEEL 451
+++L +L Q ND + Q+ A ++L D E ++ ++ +L+ + EV R E+
Sbjct: 875 ----EEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE 930
Query: 452 DRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDS 511
+ E+ KK +L+ E + L ++ + + LA ++ + ++ T + L+G+D
Sbjct: 931 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE--LSGLDE 988
Query: 512 INKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSD----- 566
L ++ H Q +++ + E + T ++L + D +
Sbjct: 989 TIAKLTREKKALQEAHQQ------ALDDLQAEEDKVNSLNKTK-SKLEQQVEDLESSLEQ 1041
Query: 567 EVSTKILMEFNKMNLPGEVTFLPLNKLDV-------------RDTAYPETNDAIPMISKL 613
E ++ +E NK L G++ + LD+ +D Y + + L
Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101
Query: 614 RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFT---MDCITLEGDQVSHR----GALTG 666
+F K K + + + + RA T E +++S R G +T
Sbjct: 1102 GL--QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 667 GYYDTRKSR----LELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIE 722
+ K R L+L++D+ +A + + A L + ++ + +ID L Q++E
Sbjct: 1160 TQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219
Query: 723 TQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSL-------QSLEASLHAMESTRE 775
++ +FK D + S M+ + + + EK + L + ++ SL + + +
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKS 1279
Query: 776 SLKAELG---------TDLLSQLSLEDQKRVDALNDEIRQLQQENR-------QLLNERI 819
L+ E G ++SQLS Q + RQL++EN+ L + R
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 820 KLEGIITRVETYL--NENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTM 877
+ + + E L++ L + E+ + R T+ T T ELE K++
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWR-TKYETDAIQRTEELEEAKKKLAQ-- 1396
Query: 878 ARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHM---DAINHDTKELE-KMTNRQGMLL 933
R +D + ++ A L+K+ +R + ++ M + N L+ K N +L
Sbjct: 1397 -RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 934 KKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNF 993
+ K +C + EL + +E+ + + L +L E+ +L+ NK + +
Sbjct: 1456 EWKTKCEESQAELEASLKES--RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513
Query: 994 SEQKEKLIKRQEELDRGYKSI-MELMNV-LELRKYEA-----------IQLTFKQVSKNF 1040
+EQ + K EL++ K I +E ++ L L + EA IQL QV
Sbjct: 1514 TEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK--- 1570
Query: 1041 SEVFQKLVPGGKATLVMKKG---DVEGSQSQDEGEGSGESE 1078
SE+ +K+ + +K+ VE QS + E +E
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611
Score = 74.7 bits (182), Expect = 5e-13
Identities = 116/633 (18%), Positives = 263/633 (41%), Gaps = 107/633 (16%)
Query: 165 TRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL-AQYQKWDKMRRAL 223
T +E K++ ++++E + E +N +E+ L+ E E+L ++ + + AL
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 224 E--YTIYNQELNETRAKLDELSAKRETSGEKSR-------QLRDAQQDARDKMEDIERQV 274
+ +++ L E + K +E A+ E S ++SR +L++A ++A D++E ++R+
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDEL----AGNSEQRKRLLKER 330
+ L+ +I+ + E+ + E K R ++EL+ D+Q L A + ++L+ +
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 331 QKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEE 390
+L + E +++AE + + +K +R + + A
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA---------------------- 1601
Query: 391 RDKWIKKELKSLDQAINDKKRQIAAIHK-DLEDTEANKE--KNLEQYNKLDQDLNEVKAR 447
+ E++S ++AI KK+ +++ +++ + AN++ + L+ + L + +
Sbjct: 1602 ----LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 448 VEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILN 507
+++ R ++K + ++ N L AE + L A E E+ ++L
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLL----QAEVEELRATLEQTERARKLAE--------- 1704
Query: 508 GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDE 567
++LD N+ VQ H ++
Sbjct: 1705 -----QELLDS------NERVQ-----------------------------LLHTQNTSL 1724
Query: 568 VSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVF 627
+ TK +E + M L EV + + + A DA M +L+ + A
Sbjct: 1725 IHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERM 1783
Query: 628 GKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTG------GYYDTRKSRLELQKD 681
K L ++ +L A + + L+G + + T +K E K
Sbjct: 1784 KKNLEQTVKDLQHRLDEA---EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 682 VRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKM 741
+RK E + EL + E+ R+N+ R+ + +D+L +++ + Q + ++ L++ +
Sbjct: 1841 LRKYERRVKELTYQSEED-RKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRK 1899
Query: 742 LKEKRQQSEKTFMPKQRSLQSLEASLHAMESTR 774
+ + +++E+ + + L A S+R
Sbjct: 1900 AQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
Score = 41.6 bits (96), Expect = 0.005
Identities = 46/229 (20%), Positives = 98/229 (42%), Gaps = 19/229 (8%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEES--ISLMKETEGK----REKINELLKYI 196
K+ + ++R++LL + ++ ++K E+ + L E E R + K I
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
Query: 197 EERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQ- 255
+ EE K+E ++M++ LE T+ + + +LDE G+K Q
Sbjct: 1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTV-----KDLQHRLDEAEQLALKGGKKQIQK 1815
Query: 256 ----LRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRT---KLELK 308
+R+ + + + + V+ L+ +KE Q +R+ ++ + KL++K
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875
Query: 309 AKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEK 357
K + + EQ L + +K ++EE ++ E + N ++ K
Sbjct: 1876 VKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 114 bits (284), Expect = 7e-25
Identities = 217/1043 (20%), Positives = 433/1043 (41%), Gaps = 172/1043 (16%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L + A T +E +K+ K E K +EE++ TL +EK +L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR---KELEEKMVTLLKEKNDLQ--- 894
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
L+ + L + + D+L + K +++ + +D + ++ +
Sbjct: 895 --------LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
R+L+ + S +K++ + L + K++ E K K+L +E+AG E +L KE++ L
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 335 EKIEEKQKELAETEPKFNSV---KEKEERGI----ARLAQATQERTDLY-AKQGRGSQFT 386
E ++ +L E K N++ K K E+ + L Q + R DL AK+
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 387 SKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKA 446
+E I+ E + LD+ + K+ +I+ + +ED +A +L + + E++A
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQA 1119
Query: 447 RVEELDRKYYEVKNKKDELQSERNYLWRE------------------------ENAEQQA 482
R+EEL+ + + + + + +R+ L RE AE Q
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 483 LAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFEC 542
+ E+ + + A K + + + + +D+ +R + Q ++ + M +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDL 1237
Query: 543 EPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYP- 601
T V GN D++S E + L ++T +L +
Sbjct: 1238 ASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRLQTESGEFSR 1295
Query: 602 ETNDAIPMISKL-RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM---DCITL---- 653
+ ++ ++S+L R F + + + K + ++ LA A DC L
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 654 EGDQVSH---RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE------------ 698
E +Q S + AL+ + + R + + D + EEL E + KL +
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 699 -----NLRRNIERINNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKR 746
+L + +R+ NE++ LM +++ ++ +QR F D IL+E K E+
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNF----DKILAEWKQKCEET 1469
Query: 747 QQSEKTFMPKQRSL--------QSLEASLHAMESTR---ESLKAELGTDLLSQLSLEDQK 795
+ + RSL + E SL +E+ + ++L+ E+ +DL Q++ E K
Sbjct: 1470 HAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI-SDLTEQIA-EGGK 1527
Query: 796 RVDALNDEIRQLQQENRQL---LNERIKL----EGIITRVETYLNE---NLRKRLDQVEQ 845
R+ L +Q++QE +L L E EG I R++ LN+ + +++ + ++
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 846 ELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQK----SM 901
E+++L+ ++ + S L+A + D + + ++ +++ E + + ++
Sbjct: 1588 EIDQLKRNH-IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 902 ERWKNME------KEHMD---AINHDTKELEKMTNRQGMLLK----------KKEECMKK 942
++N + + H+D D KE M R+ LL+ ++ E +K
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 943 IRELGSLPQEAFEKYQTL----------------SLKQLFRKLEQCNTELKKYSHVNKKA 986
I E L +A E+ Q L + Q+ ++E E + KKA
Sbjct: 1707 IAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 987 LDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQK 1046
+ +E+ +K L+R K++ + + L+LR EA QL K K QK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ----IQK 1820
Query: 1047 LVPGGKATLVMKKGDVEGSQSQD 1069
L +A + +G+VE Q ++
Sbjct: 1821 L----EARVRELEGEVESEQKRN 1839
Score = 106 bits (265), Expect = 1e-22
Identities = 212/991 (21%), Positives = 415/991 (41%), Gaps = 157/991 (15%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESIS-LMKETEGKREKINELLKYI---EE 198
K+ + A +++ L E+AG +E+I+ L KE + +E + L + E+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGL-------DETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 199 RLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSG------EK 252
+++TL + K +L Q + D + +LE E + ++D AKR+ G E
Sbjct: 1022 KVNTLTKAKIKLEQ--QVDDLEGSLE--------QEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 253 SRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDL 312
+ + +Q +K++ E ++ L++KI E+++ L + Q++IK+ L+ + ++L
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKI----EDEQALGIQLQKKIKE---LQARIEEL 1124
Query: 313 QDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET------EPKFNSVKEKEERGIAR-L 365
++E+ R + K+R L ++EE + L E + + N +E E + + R L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 366 AQATQERTDLYAKQGR---------GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAI 416
+AT + A + G Q + + + ++KE + I+D + +
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 417 HK----------DLEDTEANKEKNLEQYNKLDQDL------------------NEVKARV 448
K LED + + E+ +L DL +E +A V
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 449 EELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLE-KKQQLLRAATGKAIL- 506
+L R + +EL+ + + +NA AL + R D + ++Q KA L
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 507 NGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSD 566
+ N + +R K +Q E E A + V++
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQ--------RTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 567 EVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHV 626
S +E K L EV L LDV TN A + K + N FDK
Sbjct: 1417 CAS----LEKTKQRLQNEVEDL---MLDVE-----RTNAACAALDKKQRN--FDKILAEW 1462
Query: 627 FGKTLICRS-MEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRK 684
K + +E S + AR+ + ++ Y+ +LE L+++ +
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIK------------NAYEESLDQLETLKRENKN 1510
Query: 685 AEEELGELEAKLNENLRR--NIERINNEIDQLMNQMQ-QIETQQRKFKASRDSILSEMKM 741
++E+ +L ++ E +R +E+I +++Q ++Q +E + + IL
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 742 LKEKRQQSEKTFMPKQRSLQSLEAS-LHAMESTRESLKAELGTDLLSQLSLEDQKRVDA- 799
L + + + ++ K + L+ + + +ES + +L AE+ + ++ +K+++
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS---RNDAIRLKKKMEGD 1627
Query: 800 LNDEIRQLQQENR---QLLNERIKLEGIITRVETYLNENLRKRLDQVEQ----------- 845
LN+ QL NR + L +GI+ + +L++ LR + D EQ
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 846 --ELNELRETEGGTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGIKELQKSM 901
E+ ELR T T + +E E + ++RV+ ++ L N+ K E I ++Q M
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 902 E----RWKNMEKEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAF 954
E +N E++ AI +EL+K + L + K+ + +++L EA
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA- 1806
Query: 955 EKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR---QEELDRGY 1011
E+ K+ +KLE EL+ +K + V + E+ +K Q E DR
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR-- 1864
Query: 1012 KSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
K+I+ L ++++ K +A ++K+ ++ E
Sbjct: 1865 KNILRLQDLVD--KLQAKVKSYKRQAEEAEE 1893
Score = 80.5 bits (197), Expect = 9e-15
Identities = 158/886 (17%), Positives = 344/886 (38%), Gaps = 131/886 (14%)
Query: 145 NQMATAPDSQRL--KLLREVAGTRVYDERKEESISLMKETEGKREK----INELLKYIEE 198
N + D Q L +L +++ + E EE I + + K EK ++ L+ I E
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1154
Query: 199 RLHT--------LEEEKEELAQYQKWDKMRRALEYTIYNQELN-------------ETRA 237
RL +E K+ A++QK MRR LE E E
Sbjct: 1155 RLEEAGGATSAQIEMNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 238 KLDELSAKRETSGEKSRQLRDAQQDARDKME-------DIERQVRELKTKISAMKEEKEQ 290
++D L ++ ++ +++ D +E ++E+ R L+ ++S +K ++E+
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 291 LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPK 350
+ QR +L+ ++ + +L +L + +Q ++IEE +++L E
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 351 FNSVK-----------------EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK 393
N++ E+E+ A L +A + A Q R T +R +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA-QWRTKYETDAIQRTE 1390
Query: 394 WIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDR 453
+++ K L Q + + + A++ E K++ + L D+ A LD+
Sbjct: 1391 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 454 KYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSIN 513
K + D++ +E W+++ E A +LE Q+ R+ G + ++
Sbjct: 1451 K----QRNFDKILAE----WKQKCEETHA------ELEASQKEARSL-GTELFKIKNAYE 1495
Query: 514 KVLDHFRR-KGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKI 572
+ LD K N+++Q + E + ++ V+ ++ +
Sbjct: 1496 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ-------VEQEKCELQA 1548
Query: 573 LMEFNKMNLP---GEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
+E + +L G++ + L V+ + + I +L+ N H+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN--------HI--- 1597
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
I SM+ + D I L+ + + E ++ R + L
Sbjct: 1598 -RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 690 GELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQS 749
+ + L++ LR + L Q+ +E + +A + + + ++ + R+ +
Sbjct: 1657 KDTQIHLDDALRSQ--------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 750 EKTFMPKQRSLQSLEASLHAMESTRESLKAELGT------DLLSQLSLEDQKRVDALND- 802
E+ + +Q L ++ +T++ L+ ++ D+L + ++K A+ D
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 803 -----EIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNEL----RET 853
E+++ Q + L + +E + ++ L+E + L ++++ +L RE
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1828
Query: 854 EGGTVLTATTSELEAIN------KRVKDTMARSED-------LDNSIDKTEAGIKELQKS 900
EG V + EA+ +RVK+ ++E+ L + +DK +A +K ++
Sbjct: 1829 EG-EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 901 MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIREL 946
E + ++ ELE+ R + + + K RE+
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 62.4 bits (150), Expect = 3e-09
Identities = 112/586 (19%), Positives = 237/586 (40%), Gaps = 66/586 (11%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAK---LNENLRRNIERINN----------------- 709
+T K ++++ +K ++EL + EAK L E + ++ N+
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 710 EIDQLMNQMQQIETQQRKFKASRD-------SILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
DQL+ Q+E + ++ + + ++ + L+++ + +K + +L
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 763 LEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQEN---RQLLNE 817
+E HA E+ ++L E+ + +++L+ E + +A + LQ E L
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 818 RIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATT-----SELEAINKR 872
+IKLE + +E L + + R+D + R+ EG L + +E + ++++
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAK----RKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 873 VKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGML 932
+K +L + I+ +A +LQK ++ + +E + I + K ++ L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 933 LKKKEECMKKIRELGSLPQEAFE--KYQTLSLKQLFRKLEQCN--------TELKKYSHV 982
++ EE +++ E G E K + +++ R LE+ T KK++
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ +Q N K+KL K + E+ + + + K ++ + + SE
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSE 1264
Query: 1043 VFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSF 1102
+ K + L+ G + GE S + + S + Q +F
Sbjct: 1265 LKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ--------AF 1314
Query: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
T + E++ + K+ +A AL + CD E +Q A+ ++A+S
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQY--EEEQESKAELQRALSKANT 1372
Query: 1163 ELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDVITAEMA 1206
E+A ++ T R E LE A K + + H++ + A+ A
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/409 (20%), Positives = 180/409 (44%), Gaps = 40/409 (9%)
Query: 139 VKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINEL----LK 194
V+Q K A +++ E R+ E + + ++ K E+I++L ++
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 195 YIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQEL---NETRAKLDELSAKRETSGE 251
+E TL+ E + ++++ +E + E+ + R + L R T G
Sbjct: 1599 IVESMQSTLDAE---IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 252 KSRQLRDAQ---QDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELK 308
L+D Q DA ED++ Q+ ++ + + ++ E E+L A ++ + R E +
Sbjct: 1656 ----LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711
Query: 309 AKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGI---ARL 365
D + + Q L+ ++KL I + Q E+ + + + +EK ++ I A +
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 366 AQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQ-AINDKKRQIAAIHKDLEDTE 424
A+ ++ D A R + + E+ K ++ L +Q A+ K+QI + + + E
Sbjct: 1772 AEELKKEQDTSAHLERMKK--NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 425 ANKEKNLEQYNKLDQDLNEVKARVEEL------DRK-YYEVKNKKDELQSE-RNYLWREE 476
E ++ + + L + + RV+EL DRK +++ D+LQ++ ++Y + E
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 477 NAEQQA---------LAAKREDLEKKQQLLRAATGKAILNGIDSINKVL 516
AE+Q+ L + E+ E++ + + K + + KV+
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVI 1938
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 114 bits (284), Expect = 7e-25
Identities = 217/1043 (20%), Positives = 433/1043 (41%), Gaps = 172/1043 (16%)
Query: 155 RLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ 214
++K L + A T +E +K+ K E K +EE++ TL +EK +L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR---KELEEKMVTLLKEKNDLQ--- 894
Query: 215 KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQV 274
L+ + L + + D+L + K +++ + +D + ++ +
Sbjct: 895 --------LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 275 RELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL 334
R+L+ + S +K++ + L + K++ E K K+L +E+AG E +L KE++ L
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 335 EKIEEKQKELAETEPKFNSV---KEKEERGI----ARLAQATQERTDLY-AKQGRGSQFT 386
E ++ +L E K N++ K K E+ + L Q + R DL AK+
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 387 SKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKA 446
+E I+ E + LD+ + K+ +I+ + +ED +A +L + + E++A
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQA 1119
Query: 447 RVEELDRKYYEVKNKKDELQSERNYLWRE------------------------ENAEQQA 482
R+EEL+ + + + + + +R+ L RE AE Q
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 483 LAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFEC 542
+ E+ + + A K + + + + +D+ +R + Q ++ + M +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDL 1237
Query: 543 EPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYP- 601
T V GN D++S E + L ++T +L +
Sbjct: 1238 ASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRLQTESGEFSR 1295
Query: 602 ETNDAIPMISKL-RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM---DCITL---- 653
+ ++ ++S+L R F + + + K + ++ LA A DC L
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 654 EGDQVSH---RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE------------ 698
E +Q S + AL+ + + R + + D + EEL E + KL +
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 699 -----NLRRNIERINNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKR 746
+L + +R+ NE++ LM +++ ++ +QR F D IL+E K E+
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNF----DKILAEWKQKCEET 1469
Query: 747 QQSEKTFMPKQRSL--------QSLEASLHAMESTR---ESLKAELGTDLLSQLSLEDQK 795
+ + RSL + E SL +E+ + ++L+ E+ +DL Q++ E K
Sbjct: 1470 HAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI-SDLTEQIA-EGGK 1527
Query: 796 RVDALNDEIRQLQQENRQL---LNERIKL----EGIITRVETYLNE---NLRKRLDQVEQ 845
R+ L +Q++QE +L L E EG I R++ LN+ + +++ + ++
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 846 ELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQK----SM 901
E+++L+ ++ + S L+A + D + + ++ +++ E + + ++
Sbjct: 1588 EIDQLKRNH-IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 902 ERWKNME------KEHMD---AINHDTKELEKMTNRQGMLLK----------KKEECMKK 942
++N + + H+D D KE M R+ LL+ ++ E +K
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 943 IRELGSLPQEAFEKYQTL----------------SLKQLFRKLEQCNTELKKYSHVNKKA 986
I E L +A E+ Q L + Q+ ++E E + KKA
Sbjct: 1707 IAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 987 LDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQK 1046
+ +E+ +K L+R K++ + + L+LR EA QL K K QK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ----IQK 1820
Query: 1047 LVPGGKATLVMKKGDVEGSQSQD 1069
L +A + +G+VE Q ++
Sbjct: 1821 L----EARVRELEGEVESEQKRN 1839
Score = 106 bits (265), Expect = 1e-22
Identities = 212/991 (21%), Positives = 415/991 (41%), Gaps = 157/991 (15%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESIS-LMKETEGKREKINELLKYI---EE 198
K+ + A +++ L E+AG +E+I+ L KE + +E + L + E+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGL-------DETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 199 RLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSG------EK 252
+++TL + K +L Q + D + +LE E + ++D AKR+ G E
Sbjct: 1022 KVNTLTKAKIKLEQ--QVDDLEGSLE--------QEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 253 SRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDL 312
+ + +Q +K++ E ++ L++KI E+++ L + Q++IK+ L+ + ++L
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKI----EDEQALGIQLQKKIKE---LQARIEEL 1124
Query: 313 QDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET------EPKFNSVKEKEERGIAR-L 365
++E+ R + K+R L ++EE + L E + + N +E E + + R L
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 366 AQATQERTDLYAKQGR---------GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAI 416
+AT + A + G Q + + + ++KE + I+D + +
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 417 HK----------DLEDTEANKEKNLEQYNKLDQDL------------------NEVKARV 448
K LED + + E+ +L DL +E +A V
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 449 EELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLE-KKQQLLRAATGKAIL- 506
+L R + +EL+ + + +NA AL + R D + ++Q KA L
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 507 NGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSD 566
+ N + +R K +Q E E A + V++
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQ--------RTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 567 EVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHV 626
S +E K L EV L LDV TN A + K + N FDK
Sbjct: 1417 CAS----LEKTKQRLQNEVEDL---MLDVE-----RTNAACAALDKKQRN--FDKILAEW 1462
Query: 627 FGKTLICRS-MEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRK 684
K + +E S + AR+ + ++ Y+ +LE L+++ +
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIK------------NAYEESLDQLETLKRENKN 1510
Query: 685 AEEELGELEAKLNENLRR--NIERINNEIDQLMNQMQ-QIETQQRKFKASRDSILSEMKM 741
++E+ +L ++ E +R +E+I +++Q ++Q +E + + IL
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 742 LKEKRQQSEKTFMPKQRSLQSLEAS-LHAMESTRESLKAELGTDLLSQLSLEDQKRVDA- 799
L + + + ++ K + L+ + + +ES + +L AE+ + ++ +K+++
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS---RNDAIRLKKKMEGD 1627
Query: 800 LNDEIRQLQQENR---QLLNERIKLEGIITRVETYLNENLRKRLDQVEQ----------- 845
LN+ QL NR + L +GI+ + +L++ LR + D EQ
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 846 --ELNELRETEGGTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGIKELQKSM 901
E+ ELR T T + +E E + ++RV+ ++ L N+ K E I ++Q M
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 902 E----RWKNMEKEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAF 954
E +N E++ AI +EL+K + L + K+ + +++L EA
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA- 1806
Query: 955 EKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR---QEELDRGY 1011
E+ K+ +KLE EL+ +K + V + E+ +K Q E DR
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR-- 1864
Query: 1012 KSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
K+I+ L ++++ K +A ++K+ ++ E
Sbjct: 1865 KNILRLQDLVD--KLQAKVKSYKRQAEEAEE 1893
Score = 80.5 bits (197), Expect = 9e-15
Identities = 158/886 (17%), Positives = 344/886 (38%), Gaps = 131/886 (14%)
Query: 145 NQMATAPDSQRL--KLLREVAGTRVYDERKEESISLMKETEGKREK----INELLKYIEE 198
N + D Q L +L +++ + E EE I + + K EK ++ L+ I E
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1154
Query: 199 RLHT--------LEEEKEELAQYQKWDKMRRALEYTIYNQELN-------------ETRA 237
RL +E K+ A++QK MRR LE E E
Sbjct: 1155 RLEEAGGATSAQIEMNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 238 KLDELSAKRETSGEKSRQLRDAQQDARDKME-------DIERQVRELKTKISAMKEEKEQ 290
++D L ++ ++ +++ D +E ++E+ R L+ ++S +K ++E+
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 291 LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPK 350
+ QR +L+ ++ + +L +L + +Q ++IEE +++L E
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 351 FNSVK-----------------EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK 393
N++ E+E+ A L +A + A Q R T +R +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA-QWRTKYETDAIQRTE 1390
Query: 394 WIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDR 453
+++ K L Q + + + A++ E K++ + L D+ A LD+
Sbjct: 1391 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 454 KYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSIN 513
K + D++ +E W+++ E A +LE Q+ R+ G + ++
Sbjct: 1451 K----QRNFDKILAE----WKQKCEETHA------ELEASQKEARSL-GTELFKIKNAYE 1495
Query: 514 KVLDHFRR-KGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKI 572
+ LD K N+++Q + E + ++ V+ ++ +
Sbjct: 1496 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ-------VEQEKCELQA 1548
Query: 573 LMEFNKMNLP---GEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
+E + +L G++ + L V+ + + I +L+ N H+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN--------HI--- 1597
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
I SM+ + D I L+ + + E ++ R + L
Sbjct: 1598 -RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 690 GELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQS 749
+ + L++ LR + L Q+ +E + +A + + + ++ + R+ +
Sbjct: 1657 KDTQIHLDDALRSQ--------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 750 EKTFMPKQRSLQSLEASLHAMESTRESLKAELGT------DLLSQLSLEDQKRVDALND- 802
E+ + +Q L ++ +T++ L+ ++ D+L + ++K A+ D
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 803 -----EIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNEL----RET 853
E+++ Q + L + +E + ++ L+E + L ++++ +L RE
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1828
Query: 854 EGGTVLTATTSELEAIN------KRVKDTMARSED-------LDNSIDKTEAGIKELQKS 900
EG V + EA+ +RVK+ ++E+ L + +DK +A +K ++
Sbjct: 1829 EG-EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 901 MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIREL 946
E + ++ ELE+ R + + + K RE+
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 62.4 bits (150), Expect = 3e-09
Identities = 112/586 (19%), Positives = 237/586 (40%), Gaps = 66/586 (11%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAK---LNENLRRNIERINN----------------- 709
+T K ++++ +K ++EL + EAK L E + ++ N+
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 710 EIDQLMNQMQQIETQQRKFKASRD-------SILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
DQL+ Q+E + ++ + + ++ + L+++ + +K + +L
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 763 LEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQEN---RQLLNE 817
+E HA E+ ++L E+ + +++L+ E + +A + LQ E L
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 818 RIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATT-----SELEAINKR 872
+IKLE + +E L + + R+D + R+ EG L + +E + ++++
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAK----RKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 873 VKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGML 932
+K +L + I+ +A +LQK ++ + +E + I + K ++ L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 933 LKKKEECMKKIRELGSLPQEAFE--KYQTLSLKQLFRKLEQCN--------TELKKYSHV 982
++ EE +++ E G E K + +++ R LE+ T KK++
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ +Q N K+KL K + E+ + + + K ++ + + SE
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSE 1264
Query: 1043 VFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSF 1102
+ K + L+ G + GE S + + S + Q +F
Sbjct: 1265 LKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ--------AF 1314
Query: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
T + E++ + K+ +A AL + CD E +Q A+ ++A+S
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQY--EEEQESKAELQRALSKANT 1372
Query: 1163 ELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDVITAEMA 1206
E+A ++ T R E LE A K + + H++ + A+ A
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Score = 60.8 bits (146), Expect = 7e-09
Identities = 84/409 (20%), Positives = 180/409 (44%), Gaps = 40/409 (9%)
Query: 139 VKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINEL----LK 194
V+Q K A +++ E R+ E + + ++ K E+I++L ++
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 195 YIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQEL---NETRAKLDELSAKRETSGE 251
+E TL+ E + ++++ +E + E+ + R + L R T G
Sbjct: 1599 IVESMQSTLDAE---IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 252 KSRQLRDAQ---QDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELK 308
L+D Q DA ED++ Q+ ++ + + ++ E E+L A ++ + R E +
Sbjct: 1656 ----LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711
Query: 309 AKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGI---ARL 365
D + + Q L+ ++KL I + Q E+ + + + +EK ++ I A +
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 366 AQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQ-AINDKKRQIAAIHKDLEDTE 424
A+ ++ D A R + + E+ K ++ L +Q A+ K+QI + + + E
Sbjct: 1772 AEELKKEQDTSAHLERMKK--NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 425 ANKEKNLEQYNKLDQDLNEVKARVEEL------DRK-YYEVKNKKDELQSE-RNYLWREE 476
E ++ + + L + + RV+EL DRK +++ D+LQ++ ++Y + E
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 477 NAEQQA---------LAAKREDLEKKQQLLRAATGKAILNGIDSINKVL 516
AE+Q+ L + E+ E++ + + K + + KV+
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVI 1938
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 112 bits (279), Expect = 3e-24
Identities = 185/876 (21%), Positives = 361/876 (41%), Gaps = 157/876 (17%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL-AQYQKWDKMRRALEYTIYNQE 231
E+ + + + + K + + LL+ +E + LE+E+E+L A+ Q + L QE
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL---QE 568
Query: 232 LNET-RAKLDELSAKRETSGEKSRQLRDAQQD-----------ARDKMEDIERQVRELKT 279
N T + ++ +L+ K + E +Q ++ D A+D++ +E V EL +
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 280 KISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE 339
+++ KE+ QL QIK +T+L L A+ A + QR L +++
Sbjct: 629 QLNESKEKVSQLDI----QIKAKTELLLSAE------AAKTAQRADLQNHLDTAQNALQD 678
Query: 340 KQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTS--KEERDKWIKK 397
KQ+EL + + + V K L KQ SQ S KE ++K++
Sbjct: 679 KQQELNKITTQLDQVTAK-----------------LQDKQEHCSQLESHLKEYKEKYL-- 719
Query: 398 ELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKY-- 455
SL+Q + + QI + D + +A+KE+ L+ + Q +++ R EL ++
Sbjct: 720 ---SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
Query: 456 ---------YEVKNKKDELQSERNYLWREENAEQ----------QALAAKREDLEKKQQL 496
+++ K + L+S + L ++E +Q Q + E+L + Q
Sbjct: 777 EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQT 836
Query: 497 LRAATGK------AILNGI----DSINKVLDHFR--RKGINQHVQNGYHGIVMNNFECEP 544
K A++ + D ++KV D + + + Q G I+ C+
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 545 AFYTCVEVTAGNRLFYH------IVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDT 598
+ ++V N L + E S ++ +E N M E N L +
Sbjct: 897 LKHQ-LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ---EQLIQAQNTLKQNEK 952
Query: 599 AYPETNDAIPMISKLRYNPRFDKAFKHVFG--KTLICRSMEVSTQLARAFTMDC--ITLE 654
+ I + + + K + + G K + + E+ +L + T + E
Sbjct: 953 EEQQLQGNINELKQSSEQKK--KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 655 GDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL-------GELEAKLN---ENLRRNI 704
+++S L Y ++++ +LQ D E EL +E KL+ E+L N
Sbjct: 1011 KEKIS---VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 705 ERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM----------KMLKEKRQQSEKTFM 754
+I N+ ++L+ +++ + + A ++ L E K LKEK +EK+ +
Sbjct: 1068 NQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
Query: 755 PK--------QRSLQSLEASL--HAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEI 804
+ ++ + L L H +ES +E + LL Q LE Q + D+L +
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 805 RQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELN-ELRETEGGTV----- 858
Q ++ N+Q+L +++K E E L+K + E +L+ E++E E G
Sbjct: 1187 EQ-EKRNQQILKDQVKKE----------EEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235
Query: 859 -------LTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEH 911
+TA L + K + + R +L+ D I L+ +++ ++ +
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Query: 912 MDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELG 947
++ E+EK+ + L +K + ++ELG
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331
Score = 111 bits (277), Expect = 5e-24
Identities = 206/967 (21%), Positives = 423/967 (43%), Gaps = 130/967 (13%)
Query: 168 YDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWD--KMRRALEY 225
Y E ++ + + + + K + L+ L +LE++ EE AQ + ++ +M+ E
Sbjct: 105 YSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE-AQTENFNIKQMKDLFEQ 163
Query: 226 TIYN--QELNETRAKLDELSAKRETSGEKSRQLRDAQ-------QDARDKM------EDI 270
E+ + ++K DE + RE + +K +L + QD + ++ ED+
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223
Query: 271 ---ERQVRELKTKISAMKEEKEQLSAERQEQIK----QRTKLELKAKDLQDELAGNSEQR 323
++++ +++T + M E+E+ S + +++ K Q E L+ ELA ++
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283
Query: 324 KRLLKERQKLLEKIEE---KQKELAET----EPKFNSVKEK--EERGIARLAQATQERTD 374
++E QKL + E K + L E E + ++EK EE + QAT + D
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 375 LYAKQGRGS-------------QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421
L +Q + + + K E + +K+EL ++ K + + + E
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 422 DTEANKEKNLEQYNKL-------DQDLNEVKARVEE----LDRKYYEVKNKKDELQSERN 470
+ E + + + N+L ++ L E R++E K + + + +LQ + +
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
Query: 471 YLWRE------ENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGI 524
L + + E Q K + ++QQ L+ +T + + + +VL K
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK-- 521
Query: 525 NQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMN--LP 582
+Q +QN ++ + E + Y + + E T +L + + N L
Sbjct: 522 DQKIQN-LEALLQKSKE------NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 583 GEVTFLP---LNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFG----KTLICRS 635
+VT L N+ + A +D + K D+ + + S
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQV-QEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 636 MEVSTQL---ARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRL-ELQKDVRKAEEELGE 691
E +QL +A T ++ E + + R L + DT ++ L + Q+++ K +L +
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ-NHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 692 LEAKLNE------NLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEK 745
+ AKL + L +++ + L + +++E Q +K +A DS+ E+K KE+
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA--DSL--EVKASKEQ 748
Query: 746 RQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIR 805
Q + +QR L + + L A E +++ E+ +++S L+ QK+ +AL +
Sbjct: 749 ALQD----LQQQRQLNT-DLELRATELSKQ---LEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 806 QL--QQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATT 863
+L Q+E +Q+L + + T+++ +E L R+ EL +++ E ++T +
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQ---HEELNNRIQTTVTELQKVK-MEKEALMTELS 856
Query: 864 SELEAINKRVKDTMARSE-DLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKEL 922
+ + ++K V D++ S+ + + K +A I +L+K+ + K+ + M+ + KEL
Sbjct: 857 TVKDKLSK-VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 923 EKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCN-TELKKYSH 981
+K L K+KE + EL S+ ++ + TL + + Q N ELK+ S
Sbjct: 916 KK------SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 982 VNKKALDQF-----VNFSEQKEKLIKRQEELDRGYKSI---MELMNVLELRKYEAIQLTF 1033
KK ++ + ++ E K Q++L + + + E ++VL+ YE Q TF
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ-NNYEKSQETF 1028
Query: 1034 KQVSKNF 1040
KQ+ +F
Sbjct: 1029 KQLQSDF 1035
Score = 110 bits (274), Expect = 1e-23
Identities = 185/975 (18%), Positives = 434/975 (44%), Gaps = 106/975 (10%)
Query: 137 YIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYI 196
Y + I+Q+ S+ K +EVA VY + ++ S + E K + + E L
Sbjct: 262 YASSEATISQLR----SELAKGPQEVA---VYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 197 EERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQL 256
E+ LEE+ E + +K ++ T++ ++L+ +L ++ S ++
Sbjct: 315 EQDYTKLEEKHNEESVSKK------NIQATLHQKDLD-----CQQLQSRLSASETSLHRI 363
Query: 257 RDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDEL 316
+ + + ++ ++ E++TK +K E +QL +R+E+ + +L+ + L +L
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 317 AGNSEQ----RKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQER 372
Q RL ++RQ EK+ +K++++A+ + K + ++E+ + + + Q +
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE-LQHQ 482
Query: 373 TDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLE 432
D +Q + Q + K +++ L+Q + RQI + +++ EA +K+ E
Sbjct: 483 LDKTKQQHQEQQALQQSTTAK-LREAQNDLEQVL----RQIGDKDQKIQNLEALLQKSKE 537
Query: 433 QYNKLDQDLNEVKARVE----------ELDRKYYEVKNKKDELQSERNYLWREENAEQQA 482
+ L+++ ++ A+++ +L K + ++ + +L + L + + +QA
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK---LKNQSESHKQA 594
Query: 483 LAAKREDLEKKQQLLRAATGK--AILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF 540
+ +++++ LRAA + ++ ++ +N L+ + K +Q ++ +
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 541 ECEPAFYTCVEVTAGNRL---FYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRD 597
E A T N L + D + KI + +++ + ++L+
Sbjct: 655 E---AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 598 TAYPE--------TNDAIPMISKLRYNPRFDKAFKHVFGKTL-ICRSMEVSTQLARAFTM 648
Y E T + I KL + KA K + L R + +L
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 649 DCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNEN--LRRNIER 706
+ +E + VS +RL+LQK E +L + E L+++ E
Sbjct: 772 KQLEMEKEIVS-------------STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 707 INNEI----DQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPK----QR 758
++ E ++L N++Q T+ +K K ++++++E+ +K+K + + ++
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 759 SLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNER 818
Q +A++ +E T + LK +L + + +L++QK L + + ++ + QL E
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQM--ENTLKEQKE---LKKSLEKEKEASHQLKLEL 933
Query: 819 IKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMA 878
++ + + + L +N K Q++ +NEL+++ ++EA+ +K +
Sbjct: 934 NSMQEQLIQAQNTLKQN-EKEEQQLQGNINELKQSS-----EQKKKQIEALQGELKIAVL 987
Query: 879 RSEDLDNSIDK--TEAGIKELQKSMERWKNMEKEHMDAINHDTKELEK-MTNRQGMLLKK 935
+ +L+N + + T+A +EL E+ ++ + + K+L+ R+ LL
Sbjct: 988 QKTELENKLQQQLTQAA-QELAAEKEKISVLQNNY-EKSQETFKQLQSDFYGRESELLAT 1045
Query: 936 KEECMKKIRELGSLPQEAF--EKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNF 993
+++ +K + E SL QE + Q + +L ++L+ L++ S ++ L +
Sbjct: 1046 RQD-LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 994 SE--QKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKL--VP 1049
+ QKEK +K +E ++ KS + + ++ R+ + I +++ + E +++ +
Sbjct: 1105 LQDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 1050 GGKATLVMKKGDVEG 1064
K L+ +K +++G
Sbjct: 1163 DAKQLLIQQKLELQG 1177
Score = 71.2 bits (173), Expect = 5e-12
Identities = 119/556 (21%), Positives = 234/556 (42%), Gaps = 70/556 (12%)
Query: 72 RVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLD-KKMVTKNDVMNLLESAGF 130
R ++ +E+ +L ++KE VS R+ KK + K+ +TK + + F
Sbjct: 757 RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF 816
Query: 131 SRSNPYYIVKQGKINQ--MATAPDSQRLKLLREVAGT----------RVYDERKEESISL 178
+ ++ ++N T + Q++K+ +E T +V D K
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 179 MKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAK 238
KE + + I +L K +E H L+ + E + QK +++++LE + +
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK--ELKKSLE---------KEKEA 925
Query: 239 LDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQ 298
+L + + E+ Q ++ + + + ++ + ELK K++ E L E +
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 299 IKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE-----------KQKELAET 347
+ Q+T+LE K + + A K + Q EK +E ++ EL T
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 348 EPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIN 407
SV+EK LAQ DL + + +Q ++ + + +K +L+Q
Sbjct: 1046 RQDLKSVEEK-----LSLAQ-----EDLISNR---NQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 408 DKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQ-----DLNEVKARVE-ELDRKYYEVKNK 461
K++Q+ K L+D + KEK+L++ +++ ++ E+K R E E+ + E+K+
Sbjct: 1093 KKEQQLQERCKALQDIQ--KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH 1150
Query: 462 KDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNG---IDSINKVLDH 518
K E E L +Q L ++ +L+ K L+AA + N D + K +
Sbjct: 1151 KLESIKEITNL----KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
Query: 519 FRRKGINQ----HVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILM 574
+++ I + H + + M E A T +++TA N + + S + +
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT-MQITALNENLGTVKKEWQSSQRRVS 1265
Query: 575 EFNKM--NLPGEVTFL 588
E K +L GE+ L
Sbjct: 1266 ELEKQTDDLRGEIAVL 1281
Score = 62.0 bits (149), Expect = 3e-09
Identities = 78/358 (21%), Positives = 163/358 (45%), Gaps = 50/358 (13%)
Query: 186 REKINELLKYIEERLHTLEEEKEELAQYQKWDKMR---------RALEYTIYNQELNETR 236
R+++ +L ++E EE K+EL +YQ + + E Q+L E +
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148
Query: 237 AKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRE-LKTKISAMKEEKEQLSAER 295
+ + ++ +K+ QL D + K ++ ER +RE + K++ + EE + +
Sbjct: 149 TENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-ERSLREAAEQKVTRLTEELNKEATVI 207
Query: 296 QE---QIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKEL----AETE 348
Q+ ++ QR +E A L+ EL + ER++ EK++++ K+L A +E
Sbjct: 208 QDLKTELLQRPGIEDVAV-LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
Query: 349 PKFNSVKEKEERGIARLAQATQER-------TDLYAKQGRGSQFTSKEERDKWIKKELKS 401
+ ++ + +G +A QE +L K ++ K+E+D + K E K
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD-YTKLEEKH 325
Query: 402 LDQAINDKKRQIAAIHKDLE-----------DTEANK-----EKNLEQYNKLDQDLNEVK 445
+++++ K Q KDL+ +T ++ + E KL ++L+EV+
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 446 ARVEELDRKYYEVKNKKDE-------LQSERNYLWREENAEQQALAAKREDLEKKQQL 496
+ + L ++ +++ +++E LQSE N L + ++ L L++++QL
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 443
Score = 57.0 bits (136), Expect = 1e-07
Identities = 51/235 (21%), Positives = 108/235 (45%), Gaps = 14/235 (5%)
Query: 144 INQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTL 203
+N+ + + + +K +E T++ +E K + +KE + +++ L
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE-----------ITNLKDAKQLL 1168
Query: 204 EEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDA 263
++K EL K D ++ A+E NQ++ + + K +E K+E EK +L ++
Sbjct: 1169 IQQKLELQG--KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI-EKEAKLHSEIKEK 1225
Query: 264 RDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQR 323
M+ E +L +I+A+ E + E Q ++ ++LE + DL+ E+A
Sbjct: 1226 EVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV 1285
Query: 324 KRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAK 378
+ ER+ LLE+ + + E+ + + K ++ K + A + + +E L K
Sbjct: 1286 QNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 44.3 bits (103), Expect = 7e-04
Identities = 56/292 (19%), Positives = 127/292 (43%), Gaps = 34/292 (11%)
Query: 250 GEKSRQL-RDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQR---TKL 305
GE + L RD R +++D++ ++E K +K+E E+ +Q++ K T
Sbjct: 74 GESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 306 ELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN---SVKEKEERGI 362
+ + L+ +L + + + + +K + E+A+ + K++ S++E E+ +
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 363 ARLAQATQE--------RTDLYAKQGRGSQFTSKEE-------RDKWI---KKELKSLDQ 404
RL + + +T+L + G K+E D ++E + L
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
Query: 405 AINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDE 464
+ Q A+ + + K ++ Q+L ++K+ V EL +K + ++
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL--TENL 311
Query: 465 LQSERNYLWREENAEQQALAAK-------REDLEKKQQLLRAATGKAILNGI 509
L+ E++Y EE +++++ K ++DL+ +Q R + + L+ I
Sbjct: 312 LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 111 bits (278), Expect = 4e-24
Identities = 204/1057 (19%), Positives = 428/1057 (40%), Gaps = 161/1057 (15%)
Query: 154 QRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY 213
+ + LL + R+Y + + ++E + +K+ + +ERLH +E K + +
Sbjct: 294 ENMNLLSDARSARMY----RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 214 QKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQ 273
++ NQ L ET+ L++ + G ++R DK+ ++E++
Sbjct: 350 KE------------DNQVLLETKTMLED-----QLEGTRARS---------DKLHELEKE 383
Query: 274 VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
+LK K+ M+ E++ + +E +++ LE+ K DE S L++ +
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRT 439
Query: 334 LEKIEEKQKELAETEPKFNSVK----EKEERGIARLAQATQERTDLYAKQGRGSQFTSKE 389
E E QK L + S + E E + + + + + RT + + +G S+ E
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE--ELRTTVDSVEGNASKILKME 497
Query: 390 ERDKWIKKELKSLDQAINDKKRQI---AAIHKDLEDTEANKEKNLE--------QYNKLD 438
+ ++ + K+++ L+ I +K+ + + KDL +A EK +E Q L+
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 439 QDLNEVKARVEEL-DRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL 497
Q+ + V L R + + +++ E L E+ ++ + + + EK+Q
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL--HESIKETSSKLSKIEFEKRQ--- 612
Query: 498 RAATGKAILNGIDSINKVLDHFRRKGIN-QHVQNGYHGIVMNNFECEPAF----YTCVEV 552
I K L+H++ KG + ++N H + N + TC ++
Sbjct: 613 --------------IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 553 TAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISK 612
A + + + K L F + E ++LD + +++ S
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 613 LRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR 672
+ + K + + ++ +L +A LE VS++G D
Sbjct: 719 KMAQLQLEN--KELESEK---EQLKKGLELLKASFKKTERLE---VSYQG------LDIE 764
Query: 673 KSRLE-----LQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
RL+ K +++ E EL +LE + N+ L++N+E E+ +++Q+E + +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEME-NQTLQKNLE----ELKISSKRLEQLEKENKS 819
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELG----- 782
+ + + K L+++ ++ + K +L+ + +E ++L E+G
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 783 TDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNE----NLRK 838
L +L E+++ V +I+ L L++E++K + + +E +E L K
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 839 -RLDQVEQELNELRETEGGTVLTATTSE-LEAINKRVKDTMARSEDLDNSIDKTEAGIKE 896
RL EQ ++ R + L +T + LE +++ AR E+ N + +K
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 897 LQKSMERWKNMEKEHM----------------DAINHDTKELEKMTNR-------QGMLL 933
++K+ E K + E T+EL K+ +R L
Sbjct: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1059
Query: 934 KKKEECMKKIRELGS-----LPQEAFEKYQTLSLKQLFRKLEQCNTELK----------- 977
+K+ ++++L + Q + QT+SL++ L+ N +L+
Sbjct: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1119
Query: 978 KYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSI------MELMNVLELRKYEAI-- 1029
+ N + L Q + + E +IK +E+L Y S+ +EL++ + +YE++
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLIS 1179
Query: 1030 -QLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVP 1088
T K KN EV + + L+ +KG +E + + E ++
Sbjct: 1180 KHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
Query: 1089 SVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVAL 1125
+ G R++ T Q ++E + L K+L +L
Sbjct: 1239 EYKKLCGENDRLNHTYSQ-LLKETEVLQTDHKNLKSL 1274
Score = 77.0 bits (188), Expect = 1e-13
Identities = 159/859 (18%), Positives = 342/859 (39%), Gaps = 151/859 (17%)
Query: 157 KLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW 216
KLL + G V ++KEE I ++ + + + +I+E H +E +L +
Sbjct: 123 KLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAA--VAAHIQEVTHN-QENVFDLQWMEVT 179
Query: 217 DKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRE 276
D + +E + N L+ R +DE ET E S + RD + +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRL-IDERDEHSETIIELSEE--------RDGLHFLPH---- 226
Query: 277 LKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEK 336
A + + ++ + R L + ELA + +RL +E ++ E+
Sbjct: 227 ------ASSSAQSPCGSPGMKRTESRQHLSV-------ELADAKAKIRRLRQELEEKTEQ 273
Query: 337 IEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIK 396
+ + ++EL + E + ++++ ++ A R +L A K R ++
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-------LREKAVRVDKLE 326
Query: 397 KELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKAR---VEELDR 453
E+ + ++D + A + + ED + LE L+ L +AR + EL++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEELKEDNQV----LLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 454 KYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSIN 513
+ ++K K +++ ER+ D +K ++L+ N
Sbjct: 383 ENLQLKAKLHDMEMERDM-----------------DRKKIEELMEE-------------N 412
Query: 514 KVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKIL 573
L+ +++ +++ + G+ E E T A + H V+ S +
Sbjct: 413 MTLEMAQKQSMDESLHLGW--------ELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 574 MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLIC 633
+E +L V ++R T +A ++ + N R K +
Sbjct: 465 LEMENQSLTKTVE-------ELRTTVDSVEGNASKILKMEKENQRLSKKVE--------- 508
Query: 634 RSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELE 693
+E + +C L D + + L R++ K + + E L +
Sbjct: 509 -ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV 567
Query: 694 AKLNE----NLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQS 749
+ L + + ++ I E L +++ ++ K + + I E++ KEK +++
Sbjct: 568 SSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 750 EKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQ 809
E+ LE LH +E E L+ + ++ L + +K ++AL E +L++
Sbjct: 628 EE-----------LENELHHLEKENELLQKK-----ITNLKITCEK-IEALEQENSELER 670
Query: 810 ENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAI 869
ENR+L + + T+ E+L K Q+++E ELR L+
Sbjct: 671 ENRKLKKTLDSFKNL-----TFQLESLEKENSQLDEENLELRR---------NVESLKCA 716
Query: 870 NKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQ 929
+ ++ +++L++ ++ + G++ L+ S ++ + +E +++ ++E
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE------VSYQGLDIENQ---- 766
Query: 930 GMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNK--KAL 987
L K E KKI++L S Q+ + QTL + LE+ K+ + K K+L
Sbjct: 767 -RLQKTLENSNKKIQQLESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSL 820
Query: 988 DQFVNFSEQKEKLIKRQEE 1006
+Q + E+ +K ++++ +
Sbjct: 821 EQETSQLEKDKKQLEKENK 839
Score = 68.9 bits (167), Expect = 3e-11
Identities = 81/390 (20%), Positives = 170/390 (43%), Gaps = 53/390 (13%)
Query: 152 DSQRLKLLREVAGTRVYDERKEE------SISLMKETEGKREKINELLKYIEERLHTLEE 205
++QRL E+ + E++ S LMKE + I L + E ++ LE+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 206 EKEELAQYQKWDKMRRAL-----------EYTIYNQELNETRAKLDELSAKR-------- 246
E E L Q + R + E I ++ + ET +KL ++ ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 247 --ETSGEKSRQLRDAQQDARDKMEDIERQVRELKT---KISAMKEEKEQLSAERQEQIKQ 301
+ GE++ +L + + E +++++ LK KI A+++E +L E ++ K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 302 RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE------KQKELAETEPKFNSVK 355
K+L +L ++ +L +E +L +E K +L + S K
Sbjct: 679 LDSF----KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 356 EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAA 415
E+ ++G+ L +A+ ++T+ +G ++ + K+L+ + N K +Q+ +
Sbjct: 735 EQLKKGL-ELLKASFKKTERLEVSYQGLDIENQRLQ--------KTLENS-NKKIQQLES 784
Query: 416 IHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475
+DLE +KNLE+ + L +++ + L+++ +++ K +L+ E L ++
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 476 ENAEQQALA---AKREDLEKKQQLLRAATG 502
+ L K +LEK+ + L G
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Score = 55.8 bits (133), Expect = 2e-07
Identities = 104/500 (20%), Positives = 205/500 (41%), Gaps = 96/500 (19%)
Query: 86 DNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTK---NDVMNL---LESAGFSRSNPYYIV 139
+N+ + + + ++ ++ ++D + +K+ T+ ND+ L LE G ++ +
Sbjct: 889 ENKELVKRATIDIKTLVTLRED--LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH-- 944
Query: 140 KQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEER 199
++ +T D R KLL E K ES +L K E K EKI L +EE
Sbjct: 945 -----DEQST--DDSRYKLL----------ESKLES-TLKKSLEIKEEKIAALEARLEES 986
Query: 200 LHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
+ ++ ++EL +K Y Q +E R + + SGE ++ R++
Sbjct: 987 TNYNQQLRQELKTVKK--------NYEALKQRQDEERM----VQSSPPISGEDNKWERES 1034
Query: 260 QQDAR------DKMEDIERQVRELKTKISAMKEEKEQLSAER---QEQI----------- 299
Q+ R D++ ++ER L+ + A+K + +QL + Q QI
Sbjct: 1035 QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 300 -------KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN 352
Q KL+++ L + Q +LL ++ L + E KE + + ++
Sbjct: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
Query: 353 S-VKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKR 411
S +K+ E+ + QA++ + SK K K L+ + + D+
Sbjct: 1155 SLIKDHEKLELLHERQASEYES-----------LISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 412 QIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVE---------ELDRKYYEVKNKK 462
Q+ LED E K +EQ L ++ N E L+ Y ++ +
Sbjct: 1204 QLLKQKGQLEDLE--KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1261
Query: 463 DELQSER---NYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHF 519
+ LQ++ L EQ L A+ L+++ Q L + K + N + ++++ +
Sbjct: 1262 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK-LNNQCELLSQLKGNL 1320
Query: 520 RRKGINQHVQNGYHGIVMNN 539
+ N+H+ + +++ N
Sbjct: 1321 EEE--NRHLLDQIQTLMLQN 1338
Score = 44.7 bits (104), Expect = 5e-04
Identities = 42/181 (23%), Positives = 89/181 (49%), Gaps = 16/181 (8%)
Query: 672 RKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+K +LE + + K E+E LE K +E + +++ E D+L + Q+ + +
Sbjct: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQL-- 789
++ S + K ++ + E F + Q L+ + S K +LLSQL
Sbjct: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT---------STKLNNQCELLSQLKG 1318
Query: 790 SLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGII-TRVETYLNE--NLRKRLDQVEQE 846
+LE++ R L D+I+ L +NR LL + ++ + + Y+++ LR++ +++E++
Sbjct: 1319 NLEEENR--HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Query: 847 L 847
+
Sbjct: 1377 I 1377
Score = 38.1 bits (87), Expect = 0.051
Identities = 53/244 (21%), Positives = 105/244 (43%), Gaps = 33/244 (13%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL--AQYQKWDKMRRALEYTIYNQ 230
E+ + + + +G+ E + ++LK +E++ LE + E A+Y+K L +T Y+Q
Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHT-YSQ 1256
Query: 231 ELNETRA-KLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKE 289
L ET + D + K + K Q R L+ + S +KE+ +
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTR-------------------LEAEFSKLKEQYQ 1297
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR-LLKERQKLLEKIEEKQKELAETE 348
QL TKL + +L +L GN E+ R LL + Q L+ + ++ E++
Sbjct: 1298 QLDI-------TSTKLNNQC-ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 349 PKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
F+ + + + L + ++ + Q + + R WI +++ L ++ D
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKD 1409
Query: 409 KKRQ 412
R+
Sbjct: 1410 INRE 1413
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 111 bits (278), Expect = 4e-24
Identities = 201/1056 (19%), Positives = 425/1056 (40%), Gaps = 160/1056 (15%)
Query: 154 QRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY 213
+ + LL + R+Y + + ++E + +K+ + +ERLH +E K + +
Sbjct: 294 ENMNLLSDARSARMY----RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 214 QKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQ 273
++ NQ L ET+ L++ + G ++R DK+ ++E++
Sbjct: 350 KE------------DNQVLLETKTMLED-----QLEGTRARS---------DKLHELEKE 383
Query: 274 VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
+LK K+ M+ E++ + +E +++ LE+ K DE S L++ +
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE----SLHLGWELEQISRT 439
Query: 334 LEKIEEKQKELAETEPKFNSVK----EKEERGIARLAQATQERTDLYAKQGRGSQFTSKE 389
E E QK L + S + E E + + + + + RT + + +G S+ E
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE--ELRTTVDSVEGNASKILKME 497
Query: 390 ERDKWIKKELKSLDQAINDKKRQI---AAIHKDLEDTEANKEKNLE--------QYNKLD 438
+ ++ + K+++ L+ I +K+ + + KDL +A EK +E Q L+
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 439 QDLNEVKARVEEL-DRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLL 497
Q+ + V L R + + +++ E L E+ ++ + + + EK+Q
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL--HESIKETSSKLSKIEFEKRQ--- 612
Query: 498 RAATGKAILNGIDSINKVLDHFRRKGIN-QHVQNGYHGIVMNNFECEPAF----YTCVEV 552
I K L+H++ KG + ++N H + N + TC ++
Sbjct: 613 --------------IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 553 TAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISK 612
A + + + K L F + E ++LD + +++ S
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 613 LRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTR 672
+ + K + + ++ +L +A LE VS++G D
Sbjct: 719 KMAQLQLEN--KELESEK---EQLKKGLELLKASFKKTERLE---VSYQG------LDIE 764
Query: 673 KSRLE-----LQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
RL+ K +++ E EL +LE + N+ L++N+E E+ +++Q+E + +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEME-NQTLQKNLE----ELKISSKRLEQLEKENKS 819
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELG----- 782
+ + + K L+++ ++ + K +L+ + +E ++L E+G
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 783 TDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNE----NLRK 838
L +L E+++ V +I+ L L++E++K + + +E +E L K
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 839 -RLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKEL 897
RL EQ ++ + + + LE +++ AR E+ N + +K +
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Query: 898 QKSMERWKNMEKEHM----------------DAINHDTKELEKMTNR-------QGMLLK 934
+K+ E K + E T+EL K+ +R L
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1059
Query: 935 KKEECMKKIRELGS-----LPQEAFEKYQTLSLKQLFRKLEQCNTELK-----------K 978
+K+ ++++L + Q + QT+SL++ L+ N +L+
Sbjct: 1060 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1119
Query: 979 YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSI------MELMNVLELRKYEAI--- 1029
+ N + L Q + + E +IK +E+L Y S+ +EL++ + +YE++
Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK 1179
Query: 1030 QLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPS 1089
T K KN EV + + L+ +KG +E + + E ++
Sbjct: 1180 HGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1238
Query: 1090 VDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVAL 1125
+ G R++ T Q ++E + L K+L +L
Sbjct: 1239 YKKLCGENDRLNHTYSQ-LLKETEVLQTDHKNLKSL 1273
Score = 77.0 bits (188), Expect = 1e-13
Identities = 159/859 (18%), Positives = 342/859 (39%), Gaps = 151/859 (17%)
Query: 157 KLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKW 216
KLL + G V ++KEE I ++ + + + +I+E H +E +L +
Sbjct: 123 KLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAA--VAAHIQEVTHN-QENVFDLQWMEVT 179
Query: 217 DKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRE 276
D + +E + N L+ R +DE ET E S + RD + +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRL-IDERDEHSETIIELSEE--------RDGLHFLPH---- 226
Query: 277 LKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEK 336
A + + ++ + R L + ELA + +RL +E ++ E+
Sbjct: 227 ------ASSSAQSPCGSPGMKRTESRQHLSV-------ELADAKAKIRRLRQELEEKTEQ 273
Query: 337 IEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIK 396
+ + ++EL + E + ++++ ++ A R +L A K R ++
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-------LREKAVRVDKLE 326
Query: 397 KELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKAR---VEELDR 453
E+ + ++D + A + + ED + LE L+ L +AR + EL++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEELKEDNQV----LLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 454 KYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSIN 513
+ ++K K +++ ER+ D +K ++L+ N
Sbjct: 383 ENLQLKAKLHDMEMERDM-----------------DRKKIEELMEE-------------N 412
Query: 514 KVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKIL 573
L+ +++ +++ + G+ E E T A + H V+ S +
Sbjct: 413 MTLEMAQKQSMDESLHLGW--------ELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 574 MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLIC 633
+E +L V ++R T +A ++ + N R K +
Sbjct: 465 LEMENQSLTKTVE-------ELRTTVDSVEGNASKILKMEKENQRLSKKVE--------- 508
Query: 634 RSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELE 693
+E + +C L D + + L R++ K + + E L +
Sbjct: 509 -ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV 567
Query: 694 AKLNE----NLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQS 749
+ L + + ++ I E L +++ ++ K + + I E++ KEK +++
Sbjct: 568 SSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 750 EKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQ 809
E+ LE LH +E E L+ + ++ L + +K ++AL E +L++
Sbjct: 628 EE-----------LENELHHLEKENELLQKK-----ITNLKITCEK-IEALEQENSELER 670
Query: 810 ENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAI 869
ENR+L + + T+ E+L K Q+++E ELR L+
Sbjct: 671 ENRKLKKTLDSFKNL-----TFQLESLEKENSQLDEENLELRR---------NVESLKCA 716
Query: 870 NKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQ 929
+ ++ +++L++ ++ + G++ L+ S ++ + +E +++ ++E
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE------VSYQGLDIENQ---- 766
Query: 930 GMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNK--KAL 987
L K E KKI++L S Q+ + QTL + LE+ K+ + K K+L
Sbjct: 767 -RLQKTLENSNKKIQQLESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSL 820
Query: 988 DQFVNFSEQKEKLIKRQEE 1006
+Q + E+ +K ++++ +
Sbjct: 821 EQETSQLEKDKKQLEKENK 839
Score = 68.9 bits (167), Expect = 3e-11
Identities = 81/390 (20%), Positives = 170/390 (43%), Gaps = 53/390 (13%)
Query: 152 DSQRLKLLREVAGTRVYDERKEE------SISLMKETEGKREKINELLKYIEERLHTLEE 205
++QRL E+ + E++ S LMKE + I L + E ++ LE+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 206 EKEELAQYQKWDKMRRAL-----------EYTIYNQELNETRAKLDELSAKR-------- 246
E E L Q + R + E I ++ + ET +KL ++ ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 247 --ETSGEKSRQLRDAQQDARDKMEDIERQVRELKT---KISAMKEEKEQLSAERQEQIKQ 301
+ GE++ +L + + E +++++ LK KI A+++E +L E ++ K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 302 RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE------KQKELAETEPKFNSVK 355
K+L +L ++ +L +E +L +E K +L + S K
Sbjct: 679 LDSF----KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 356 EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAA 415
E+ ++G+ L +A+ ++T+ +G ++ + K+L+ + N K +Q+ +
Sbjct: 735 EQLKKGL-ELLKASFKKTERLEVSYQGLDIENQRLQ--------KTLENS-NKKIQQLES 784
Query: 416 IHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475
+DLE +KNLE+ + L +++ + L+++ +++ K +L+ E L ++
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 476 ENAEQQALA---AKREDLEKKQQLLRAATG 502
+ L K +LEK+ + L G
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Score = 54.3 bits (129), Expect = 7e-07
Identities = 88/410 (21%), Positives = 167/410 (40%), Gaps = 69/410 (16%)
Query: 170 ERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYN 229
E K ES +L K E K EKI L +EE + ++ ++EL +K Y
Sbjct: 957 ESKLES-TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK--------NYEALK 1007
Query: 230 QELNETRAKLDELSAKRETSGEKSRQLRDAQQDAR------DKMEDIERQVRELKTKISA 283
Q +E R + + SGE ++ R++Q+ R D++ ++ER L+ + A
Sbjct: 1008 QRQDEERM----VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1063
Query: 284 MKEEKEQLSAER---QEQI------------------KQRTKLELKAKDLQDELAGNSEQ 322
+K + +QL + Q QI Q KL+++ L + Q
Sbjct: 1064 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 323 RKRLLKERQKLLEKIEEKQKELAETEPKFNS-VKEKEERGIARLAQATQERTDLYAKQGR 381
+LL ++ L + E KE + + ++S +K+ E+ + QA++ +
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES-------- 1175
Query: 382 GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDL 441
SK K K L+ + + D+ Q+ LED E K +EQ L ++
Sbjct: 1176 ---LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--KMLKVEQEKMLLENK 1230
Query: 442 NEVKARVE---------ELDRKYYEVKNKKDELQSER---NYLWREENAEQQALAAKRED 489
N E L+ Y ++ + + LQ++ L EQ L A+
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
Query: 490 LEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNN 539
L+++ Q L + K + N + ++++ + + N+H+ + +++ N
Sbjct: 1291 LKEQYQQLDITSTK-LNNQCELLSQLKGNLEEE--NRHLLDQIQTLMLQN 1337
Score = 49.7 bits (117), Expect = 2e-05
Identities = 103/538 (19%), Positives = 205/538 (38%), Gaps = 65/538 (12%)
Query: 125 LESAGFSRSNPYYIVKQGK-INQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETE 183
LE S + K+ K + Q + + + +L +E R E K+ ++
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 184 GKREKINELLK-----YIEE--RLHTLEEEKEELAQYQ----------KWDKMRRALEYT 226
G EK N+ L Y E RL LE+E +EL + + D + L+
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
Query: 227 IYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKE 286
N +L + +L+++ +E + D + K+E ++ E+K + A E
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALE 979
Query: 287 EKEQLSAERQEQIKQRTKLELK----AKDLQDE---------LAG--------NSEQRKR 325
+ + S +Q++Q K K K QDE ++G + E +
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQF 385
LLK + +L+E AE + +K+ E + AQ + + Q + +
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
Query: 386 TSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQ----YNKLDQDL 441
++ + + L S ++ ++ Q+ LE+ + K E Y+ L +D
Sbjct: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYL---WREENAEQQALAAKREDLEKKQQLLR 498
+++ E +Y + +K L+S L R+ L ++ LE +++L+
Sbjct: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
Query: 499 AATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL 558
K +L + ++ + G N + + Y ++ T V T L
Sbjct: 1220 VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE---------TEVLQTDHKNL 1270
Query: 559 FYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYN 616
+ +S T++ EF+K+ +LD+ T + N+ ++S+L+ N
Sbjct: 1271 KSLLNNSKLEQTRLEAEFSKLK-------EQYQQLDITST---KLNNQCELLSQLKGN 1318
Score = 44.7 bits (104), Expect = 5e-04
Identities = 42/181 (23%), Positives = 89/181 (49%), Gaps = 16/181 (8%)
Query: 672 RKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKAS 731
+K +LE + + K E+E LE K +E + +++ E D+L + Q+ + +
Sbjct: 1207 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1266
Query: 732 RDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQL-- 789
++ S + K ++ + E F + Q L+ + S K +LLSQL
Sbjct: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT---------STKLNNQCELLSQLKG 1317
Query: 790 SLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGII-TRVETYLNE--NLRKRLDQVEQE 846
+LE++ R L D+I+ L +NR LL + ++ + + Y+++ LR++ +++E++
Sbjct: 1318 NLEEENR--HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Query: 847 L 847
+
Sbjct: 1376 I 1376
Score = 38.9 bits (89), Expect = 0.030
Identities = 67/311 (21%), Positives = 130/311 (41%), Gaps = 49/311 (15%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL--AQYQKWDKMRRALEYTIYNQ 230
E+ + + + +G+ E + ++LK +E++ LE + E A+Y+K L +T Y+Q
Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHT-YSQ 1255
Query: 231 ELNETRA-KLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKE 289
L ET + D + K + K Q R L+ + S +KE+ +
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTR-------------------LEAEFSKLKEQYQ 1296
Query: 290 QLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE- 348
QL + Q L +L++E +Q + L+ + + LLE+ E K+L E
Sbjct: 1297 QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNME-SKDLFHVEQ 1355
Query: 349 ----PKFNSVKEKEERGIARLAQATQERTDLY---AKQGRGSQFT--------SKEERDK 393
K N ++ ++E +L + ++ Y + RG+ T SK++ ++
Sbjct: 1356 RQYIDKLNELRRQKE----KLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1411
Query: 394 WIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDR 453
+K L + + + H+D +D+ + +LE Q L K+ + L R
Sbjct: 1412 ERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED----GQTLGTKKSSMVALKR 1467
Query: 454 KYYEVKNKKDE 464
+ KD+
Sbjct: 1468 LPFLRNRPKDK 1478
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 110 bits (275), Expect = 8e-24
Identities = 207/1026 (20%), Positives = 421/1026 (41%), Gaps = 167/1026 (16%)
Query: 173 EESISLMKE----TEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY 228
E+ ++ MKE T+ + K K +EE++ TL +EK +L L+
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQ-----------LQVQSE 897
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEK 288
L + + ++L + K +++ + ++ + ++ + R+L+ + S +K++
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957
Query: 289 EQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE 348
+ L + K++ E K K+L +E+AG E +L KE++ L E ++ +L E
Sbjct: 958 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 349 PKFN---SVKEKEERGI----ARLAQATQERTDL-YAKQGRGSQFTSKEERDKWIKKELK 400
K N K K E+ + L Q + R DL AK+ +E ++ + +
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077
Query: 401 SLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
LD+ + K+ +I+ + +ED +A + +L + + E++AR+EEL + +
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVE-------IQLQKKIKELQARIEELGEEIEAERA 1130
Query: 461 KKDELQSERNYLWRE------------------------ENAEQQALAAKREDLEKKQQL 496
+ + + +R+ L RE AE Q L E+ + +
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEA 1190
Query: 497 LRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGN 556
+ AA K + + + + +D+ +R + Q ++ + M + + + GN
Sbjct: 1191 MVAALRKKHADSMAELGEQIDNLQR--VKQKLEKEKSELKMETDDLS-SNAEAISKAKGN 1247
Query: 557 RLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYN 616
D+VS E + L ++T + ++ ++S+L +
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRS 1307
Query: 617 PRFD----KAFKHVF-----GKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGG 667
+ + KH K + +++ S + + + AL+
Sbjct: 1308 KQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA 1367
Query: 668 YYDTRKSRLELQKDVRKAEEELGELEAKLNE-----------------NLRRNIERINNE 710
+ + R + + D + EEL E + KL + +L + +R+ NE
Sbjct: 1368 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNE 1427
Query: 711 IDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQS- 762
++ LM +++ ++ +QR F D +LSE K E+ Q + + RSL +
Sbjct: 1428 VEDLMLDVERSNAACAALDKKQRNF----DKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 763 -------LEASLHAMESTR---ESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENR 812
E SL +E+ R ++L+ E+ +DL Q++ E K++ L +Q++QE
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEI-SDLTEQIA-EGGKQIHELEKIKKQVEQEKC 1541
Query: 813 QL---LNERIKL----EGIITRVETYLNE---NLRKRLDQVEQELNELRETEGGTVLTAT 862
++ L E EG I R++ LN+ + +++ + ++E+++L+ V T
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET-M 1600
Query: 863 TSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQK----SMERWKNME---KE---HM 912
S L+A + D + + ++ +++ E + + S+ ++N + KE H+
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL 1660
Query: 913 DAI---NHDTKELEKMTNRQGMLLK----------KKEECMKKIRELGSLPQEAFEKYQT 959
D D KE + R+ LL+ ++ E +KI E L +A E+ Q
Sbjct: 1661 DDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELL--DASERVQL 1718
Query: 960 L----------------SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR 1003
L + QL ++E+ E + KKA+ +E+ +K
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 1004 QEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVE 1063
L+R K++ + + L+ R EA QL K K QKL +A + +G+VE
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ----IQKL----EARVRELEGEVE 1830
Query: 1064 GSQSQD 1069
Q ++
Sbjct: 1831 NEQKRN 1836
Score = 105 bits (263), Expect = 2e-22
Identities = 210/989 (21%), Positives = 426/989 (43%), Gaps = 153/989 (15%)
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESIS-LMKETEGKREKINELLKYI---EE 198
K+ + A +++ L E+AG +E+I+ L KE + +E + L + E+
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGL-------DETIAKLSKEKKALQETHQQTLDDLQAEED 1018
Query: 199 RLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSG------EK 252
+++ L + K +L Q + D + +LE E + ++D AKR+ G E
Sbjct: 1019 KVNILTKAKTKLEQ--QVDDLEGSLE--------QEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 253 SRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDL 312
+ + + +Q +K+E E ++ L +KI E+++ + + Q++IK+ L+ + ++L
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKI----EDEQAVEIQLQKKIKE---LQARIEEL 1121
Query: 313 QDELAGNSEQRKRLLKERQKLLEKIEEKQKELAET------EPKFNSVKEKEERGIAR-L 365
+E+ R + K+R L ++EE + L E + + N +E E + + R L
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 1181
Query: 366 AQAT-----------QERTDLYAKQG-------RGSQFTSKEERD-KWIKKELKSLDQAI 406
+AT ++ D A+ G R Q KE+ + K +L S +AI
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241
Query: 407 NDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQ 466
+ K + + + LED + + E+ +L DL +AR++ +Y ++KD L
Sbjct: 1242 SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV 1301
Query: 467 SERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQ 526
S+ L R + A Q + + LE++ + A+ + + S D R + +
Sbjct: 1302 SQ---LSRSKQASTQQIEELKHQLEEETK-----AKNALAHALQSSRHDCDLLREQYEEE 1353
Query: 527 HVQNGYHGIVMNNFECEPAFYTCVEVT-----------AGNRLFYHIVDSDE----VSTK 571
++ E A + T A +L + +++E V+ K
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 572 IL-MEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKA---FKHVF 627
+E K L EV L LDV +N A + K + N FDK +K +
Sbjct: 1414 CASLEKTKQRLQNEVEDL---MLDVE-----RSNAACAALDKKQRN--FDKVLSEWKQKY 1463
Query: 628 GKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRKAE 686
+T +E S + +R+ + + ++ Y+ +LE L+++ + +
Sbjct: 1464 EETQ--AELEASQKESRSLSTELFKVK------------NVYEESLDQLETLRRENKNLQ 1509
Query: 687 EELGELEAKLNENLRR--NIERINNEIDQLMNQMQ-QIETQQRKFKASRDSILSEMKMLK 743
+E+ +L ++ E ++ +E+I +++Q ++Q +E + + IL L
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELN 1569
Query: 744 EKRQQSEKTFMPKQRSLQSLEAS-LHAMESTRESLKAELGTDLLSQLSLEDQKRVDA-LN 801
+ + + ++ K + L+ + +E+ + +L AE+ + +L +K+++ LN
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS---RNDALRVKKKMEGDLN 1626
Query: 802 DEIRQLQQENR---QLLNERIKLEGIITRVETYLNENLRKRLDQVEQ------------- 845
+ QL NR + L +GI+ + +L++ LR + D EQ
Sbjct: 1627 EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1686
Query: 846 ELNELRETEGGTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGIKELQKSME- 902
E+ EL T T + +E E + ++RV+ ++ L N+ K E + +LQ +E
Sbjct: 1687 EIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEE 1746
Query: 903 ---RWKNMEKEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEK 956
+N E++ AI +EL+K + L + K+ + +++L EA E+
Sbjct: 1747 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-EQ 1805
Query: 957 YQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR---QEELDRGYKS 1013
K+ +KLE EL+ +K + V + E+ +K Q E DR K+
Sbjct: 1806 LALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDR--KN 1863
Query: 1014 IMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
++ L ++++ K +A ++K+ ++ E
Sbjct: 1864 VLRLQDLVD--KLQAKVKSYKRQAEEAEE 1890
Score = 81.3 bits (199), Expect = 5e-15
Identities = 180/940 (19%), Positives = 373/940 (39%), Gaps = 173/940 (18%)
Query: 266 KMEDIERQVRELKTKISAMKEEKEQLSAERQE-------QIKQRTKLELKAKDLQDELAG 318
K + E+++ +K + K+E + A+R+E +K++ L+L+ + D LA
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 319 NSEQRKRLLKERQKL---LEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDL 375
E+ ++L+K + +L ++++ E+ +E E + + K K E + L + +
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 376 YAKQGRGSQFTSKEERDKWIKKELKSLDQAI---NDKKRQIAAIHKD-LEDTEANKEK-- 429
AK + T E + K + +E+ LD+ I + +K+ + H+ L+D +A ++K
Sbjct: 964 LAKVEKEKHAT--ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 1021
Query: 430 ------------------NLEQYNKLDQDLNEVKARV----------------------E 449
+LEQ KL DL K ++ E
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081
Query: 450 ELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGI 509
+L++K +E+ N +++ E+ + + ++ L A+ E+L ++ + RA+ KA
Sbjct: 1082 KLEKKEFEISNLISKIEDEQAVEIQLQKKIKE-LQARIEELGEEIEAERASRAKAEKQRS 1140
Query: 510 DSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVS 569
D +++ L+ I++ ++ E T +V + +
Sbjct: 1141 D-LSRELEE-----ISERLE-------------EAGGATSAQVELNKK-------REAEF 1174
Query: 570 TKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
K+ + + L E L K A E + I + +++ +K+ +
Sbjct: 1175 QKLRRDLEEATLQHEAMVAALRKKHADSMA--ELGEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYY----DTRKSRLELQKDVRKA 685
L + +S M C +LE DQVS D R LQ + +
Sbjct: 1233 DLSSNAEAISKAKGNLEKM-CRSLE-DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEY 1290
Query: 686 EEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEK 745
+L E +A +++ L R+ + +I++L +Q+++ + + S + +L+E+
Sbjct: 1291 SRQLDEKDALVSQ-LSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 746 RQQSEKTFMPKQRSLQSLEASL------HAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
++ ++ QR+L + + + ++ + + + E L+Q E ++ V+A
Sbjct: 1350 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVE---------TYLNENLRKRLDQVEQELNEL 850
+N + L++ ++L NE +E ++ VE N K L + +Q+ E
Sbjct: 1410 VNAKCASLEKTKQRLQNE---VEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEET 1466
Query: 851 R-ETEGG---------------TVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGI 894
+ E E V + +LE + + K+ DL I + I
Sbjct: 1467 QAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI 1526
Query: 895 KELQKSMERWKNMEKEHMDAINHDTKELE----KMTNRQGMLLKKKEECMKKIRE----- 945
EL+K ++ + + E A+ LE K+ Q L + K E +KI E
Sbjct: 1527 HELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1586
Query: 946 --------------LGSLPQEAFEKYQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQF 990
+L E + L +K +K+E E++ + +H N+ A +
Sbjct: 1587 DQLKRNHTRVVETMQSTLDAEIRSRNDALRVK---KKMEGDLNEMEIQLNHANRLAAESL 1643
Query: 991 VNFSEQKEKLIKRQEELD---RGYKSIMELMNVLELR------KYEAIQLTFKQVSKNFS 1041
N+ + L + Q LD RG + + E + ++E R + E + T +Q ++
Sbjct: 1644 RNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRK 1703
Query: 1042 EVFQKLVPGGK---------ATLVMKKGDVEGSQSQDEGE 1072
Q+L+ + +L+ K +E SQ + E
Sbjct: 1704 IAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSE 1743
Score = 74.7 bits (182), Expect = 5e-13
Identities = 149/774 (19%), Positives = 307/774 (39%), Gaps = 125/774 (16%)
Query: 94 EEVS--LRRVIGAKKDQYFLDKKMVTKNDVMNL-LESAGFSRSNPYYIVKQGKINQMATA 150
EE+S L GA Q L+KK + + LE A +++ + MA
Sbjct: 1147 EEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAEL 1206
Query: 151 PDS----QRLK--LLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLE 204
+ QR+K L +E + ++ + + + + +G EK+ L+ L T E
Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266
Query: 205 EEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDAR 264
EE++ L + R E Y+++L+E A + +LS ++ S ++ +L+ ++
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 1326
Query: 265 DKMEDIERQVRELKTKISAMKEEKEQ-----------LSAERQEQIKQRTKLELKAKDLQ 313
+ ++ + ++E+ E+ LS E + RTK E A
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386
Query: 314 DELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKE----------------- 356
+EL ++ + L+E ++ +E + K L +T+ + + E
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 357 KEERGIARLA-------QATQERTDLYAKQGRG---------SQFTSKEERDKWIKKELK 400
K++R ++ + TQ + K+ R + + ++ + +++E K
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENK 1506
Query: 401 SLDQAINDKKRQIAA---------------------IHKDLEDTEANKEKNLEQYNKLDQ 439
+L Q I+D QIA I LE+ EA+ E + ++
Sbjct: 1507 NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQL 1566
Query: 440 DLNEVKARVEELDRKYYEVKNKKDEL--------QSERNYLWREENAEQQALAAKRE--- 488
+LN+VK+ E+DRK E + D+L ++ ++ L E + AL K++
Sbjct: 1567 ELNQVKS---EVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG 1623
Query: 489 DLEKKQQLLRAATGKAI-----------------------LNGIDSINKVLDHFRRKG-- 523
DL + + L A A L G + + + L R+
Sbjct: 1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL 1683
Query: 524 INQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPG 583
+ ++ + + + A ++ + +L H ++ ++TK +E + L
Sbjct: 1684 LQAEIEELWATLEQTERSRKIAEQELLDASERVQLL-HTQNTSLINTKKKLENDVSQLQS 1742
Query: 584 EVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLA 643
EV + + + A DA M +L+ + A K L ++ +L
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLD 1801
Query: 644 RAFTMDCITLEGD--QVSHRGA----LTGGYYDTRKSRLELQKDVRKAEEELGELEAKLN 697
A + + L+G Q+ A L G + +K E K +RK E + EL +
Sbjct: 1802 EA---EQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTE 1858
Query: 698 ENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEK 751
E+ R+N+ R+ + +D+L +++ + Q + + ++ LS+ + L+ + +++E+
Sbjct: 1859 ED-RKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Score = 65.5 bits (158), Expect = 3e-10
Identities = 94/394 (23%), Positives = 175/394 (44%), Gaps = 57/394 (14%)
Query: 88 RLPIDKEEVSLRRVIGAKKDQYFLDKKMVTK--NDVMNLLESAGFSRSNPYYIVK--QGK 143
+L +++ + + R I K ++ K+ T+ + + L++ SR++ + K +G
Sbjct: 1565 QLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD 1624
Query: 144 INQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETE-------GKREKINELLKYI 196
+N+M +L +A + + R + I +KET+ +E + E L +
Sbjct: 1625 LNEMEI-----QLNHANRLAAESLRNYRNTQGI--LKETQLHLDDALRGQEDLKEQLAIV 1677
Query: 197 EERLHTLEEEKEEL-AQYQKWDKMRRALEYTIY------------NQELNETRAKLD-EL 242
E R + L+ E EEL A ++ ++ R+ E + N L T+ KL+ ++
Sbjct: 1678 ERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDV 1737
Query: 243 SAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQR 302
S + E ++ R+A++ A+ + D ELK KEQ ++ E++K+
Sbjct: 1738 SQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELK---------KEQDTSAHLERMKKN 1788
Query: 303 TKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKEL---AETEPKFNS--VK-- 355
LE KDLQ L E + LK +K ++K+E + +EL E E K N+ VK
Sbjct: 1789 --LEQTVKDLQHRL---DEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGL 1843
Query: 356 EKEERGIARLAQATQE-RTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIA 414
K ER + L T+E R ++ Q + +K K K++ + ++ N +
Sbjct: 1844 RKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKV---KSYKRQAEEAEEQSNANLSKFR 1900
Query: 415 AIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARV 448
+ +LE+ E + Q NKL EV ++
Sbjct: 1901 KLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 61.2 bits (147), Expect = 6e-09
Identities = 83/372 (22%), Positives = 165/372 (44%), Gaps = 46/372 (12%)
Query: 173 EESISLMKETEGKREKINELLKYIEERL-HTLEEEKEELAQYQKWDKMRRALEYTIYNQE 231
EE+ + ++ EGK +I L ++ + + E+ EE+ Q ++ R +E T+ +
Sbjct: 1548 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR--NHTRVVE-TMQSTL 1604
Query: 232 LNETRAKLDELSAKRETSG-----------------EKSRQLRDAQ----------QDAR 264
E R++ D L K++ G E R R+ Q DA
Sbjct: 1605 DAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664
Query: 265 DKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRK 324
ED++ Q+ ++ + + ++ E E+L A ++ + R E + D + + Q
Sbjct: 1665 RGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNT 1724
Query: 325 RLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGI---ARLAQATQERTDLYAKQGR 381
L+ ++KL + + Q E+ E + + +EK ++ I A +A+ ++ D A R
Sbjct: 1725 SLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1784
Query: 382 GSQFTSKEERDKWIKKELKSLDQ-AINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQD 440
+ + E+ K ++ L +Q A+ K+QI + + + E E ++ + +
Sbjct: 1785 MKK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG 1842
Query: 441 LNEVKARVEEL------DRK-YYEVKNKKDELQSE-RNYLWREENAEQQALAAKREDLEK 492
L + + RV+EL DRK +++ D+LQ++ ++Y + E AE+Q+ A K
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQS-NANLSKFRK 1901
Query: 493 KQQLLRAATGKA 504
Q L A +A
Sbjct: 1902 LQHELEEAEERA 1913
Score = 59.7 bits (143), Expect = 2e-08
Identities = 122/595 (20%), Positives = 240/595 (40%), Gaps = 84/595 (14%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIE----------RINNEIDQLMNQMQ 719
+T K ++++ +K ++EL + EAK E + + ++ +E D L + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 720 QIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQ------------------ 761
+ E Q K K ++ + E+ E+ ++ K+R L+
Sbjct: 907 RCE-QLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 762 SLEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQENRQ---LLN 816
+E HA E+ ++L E+ + +++LS E + + + LQ E + L
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 817 ERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLT-ATTSELEAINKRVKD 875
+ KLE + +E L + + R+D + R+ EG L +T ++E +++ +
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAK----RKLEGDLKLAQESTMDMENDKQQLDE 1081
Query: 876 TMARSE-DLDNSIDKTE---AGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGM 931
+ + E ++ N I K E A +LQK ++ + +E + I + K ++
Sbjct: 1082 KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSD 1141
Query: 932 LLKKKEECMKKIRELG--SLPQEAFEKYQTLSLKQLFRKLEQCNTE--------LKKYSH 981
L ++ EE +++ E G + Q K + ++L R LE+ + KK++
Sbjct: 1142 LSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD 1201
Query: 982 VNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFK---QVS- 1037
+ +Q N K+KL K + EL + + K ++ QVS
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 1038 -KNFSEVFQKLV---PGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQF 1093
K E Q+L+ +A L + G E S+ DE + S+ Q+S ++
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAG--EYSRQLDEKDAL-VSQLSRSKQASTQQIE-- 1316
Query: 1094 TGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQH 1153
E++ + K+ +A AL + CD E +Q A+
Sbjct: 1317 --------------ELKHQLEEETKAKNALAHALQSSRHDCDLLREQY--EEEQEGKAEL 1360
Query: 1154 RKAVSDMIMELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDVITAEMA 1206
++A+S E+A ++ T R E LE A K + + H++ + A+ A
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Score = 51.6 bits (122), Expect = 4e-06
Identities = 50/227 (22%), Positives = 112/227 (49%), Gaps = 23/227 (10%)
Query: 276 ELKTKISAMKEEKEQ--LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
++K + + + EKE + E Q+ + K E K K+L++++ LLKE+ L
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMV-------TLLKEKNDL 890
Query: 334 LEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK 393
+++ + LA+ E + + + + + A++ + T+ + ++ ++ T+K+ +
Sbjct: 891 QLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEE---EEEINAELTAKKRK-- 945
Query: 394 WIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNL-EQYNKLDQDLNEVKARVEELD 452
++ E L + I+D + +A + K+ TE NK KNL E+ LD+ + ++ + L
Sbjct: 946 -LEDECSELKKDIDDLELTLAKVEKEKHATE-NKVKNLTEEMAGLDETIAKLSKEKKALQ 1003
Query: 453 RKYYEVKNKKDELQSER---NYLWREENAEQQALAAKREDLEKKQQL 496
+ + D+LQ+E N L + + +Q + LE++++L
Sbjct: 1004 ETHQQT---LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKL 1047
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/323 (19%), Positives = 137/323 (42%), Gaps = 50/323 (15%)
Query: 673 KSRLELQKDVRKAEEELGELEAKLN-------ENLR--RNIERINNEI-----------D 712
+SR + + +K E +L E+E +LN E+LR RN + I E +
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668
Query: 713 QLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMES 772
L Q+ +E + +A + + + ++ + R+ +E+ + +Q L ++ +
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1728
Query: 773 TRESLKAELGT------DLLSQLSLEDQKRVDALND------EIRQLQQENRQLLNERIK 820
T++ L+ ++ +++ + ++K A+ D E+++ Q + L +
Sbjct: 1729 TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1788
Query: 821 LEGIITRVETYLNENLRKRLDQVEQELNEL----RETEGGTVLTATTSELEAIN------ 870
LE + ++ L+E + L ++++ +L RE EG V EA+
Sbjct: 1789 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG-EVENEQKRNAEAVKGLRKHE 1847
Query: 871 KRVKDTMARSED-------LDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELE 923
+RVK+ ++E+ L + +DK +A +K ++ E + ++ ELE
Sbjct: 1848 RRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELE 1907
Query: 924 KMTNRQGMLLKKKEECMKKIREL 946
+ R + + + K RE+
Sbjct: 1908 EAEERADIAESQVNKLRVKSREV 1930
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 108 bits (271), Expect = 2e-23
Identities = 178/971 (18%), Positives = 414/971 (42%), Gaps = 158/971 (16%)
Query: 153 SQRLKLLREVAGTRVYDERKEESISLMKETEGKRE-------KINELLKYIEERLHTLEE 205
S+ L + T+ ++K I ++ E K K NE+++ + ++ +L +
Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ-QRKIFSLIQ 1050
Query: 206 EKEELAQY---------QKWDKMRRALEYTIYNQELNETRAKLDELSAKRE-TSGEKSRQ 255
EK EL Q Q ++ +E TI NQE E R DEL ++E + EK+
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE--ELRLLGDELKKQQEIVAQEKNHA 1108
Query: 256 LRDAQQDAR--DKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQ 313
++ + +R D++ ++E +++E ++ +EK+Q QE++ + K + ++L+
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQL----QEKQQQLLNVQEEMSEMQKKINEIENLK 1164
Query: 314 DELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEE---------RGIAR 364
+EL + + ER +L +K+ E +E+ + +KE ++ RG R
Sbjct: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
Query: 365 LAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIN--DKKRQIAAIHKDLED 422
+AT +T K +E D+ + + Q IN D ++ + +++
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV 1284
Query: 423 TEANKE--KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ 480
+E N+++ ++ + +NE++ E+ K + + + N ++E E
Sbjct: 1285 LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344
Query: 481 QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF 540
++L +R++L+ ++ L + + +H++ I +
Sbjct: 1345 KSLTKERDNLKTIKEALEV--------------------KHDQLKEHIRETLAKIQESQS 1384
Query: 541 ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMN------LPGEVTFLPLNKLD 594
+ E + ++ + D +TKI+ E + L E+ L L+K
Sbjct: 1385 KQEQSL--------------NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK-- 1428
Query: 595 VRDTAYPETNDAIPMISKLR---------YNPRFDKAFKHVFGKTLICRSMEVSTQLARA 645
E++D + ++K + D+ +++ K ++ + +E +L A
Sbjct: 1429 ----RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI--KEIVAKHLETEEELKVA 1482
Query: 646 FTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRR--- 702
C+ + + ++ + R + E + ++ +++L + KL ++
Sbjct: 1483 HC--CLKEQEETIN----------ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE 1530
Query: 703 -----NIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQ 757
NI++I+ E+ + +N+++Q + ++ ++ SI S+M L + Q+S++
Sbjct: 1531 KEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
Query: 758 RSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKR--------VDALNDEIRQLQQ 809
+ + ++ A++ R+ LK E ++++++ +K V+ +++ +++
Sbjct: 1590 KEKEEMKRVQEALQIERDQLK-ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 810 ENRQLLNERIKLEGIIT---RVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSEL 866
Q +++ LE I T R+ L+ENL + + V +E ++LR E E
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEE-MRSVTKERDDLRSVE-----ETLKVER 1702
Query: 867 EAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMT 926
+ + + +++T+ R + + +KE Q+++++ + + E + I++ K+LE
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 927 NR--------------QGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC 972
+ M LK+++E + K+R + S EK LS Q + LE
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS------EKTDKLSNMQ--KDLENS 1814
Query: 973 NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLT 1032
N +L++ K Q + + + K+ E+++ K I + L + E + L
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 1033 FKQVSKNFSEV 1043
+++ +N E+
Sbjct: 1875 -QKLHENLEEM 1884
Score = 93.2 bits (230), Expect = 1e-18
Identities = 196/1002 (19%), Positives = 410/1002 (40%), Gaps = 183/1002 (18%)
Query: 142 GKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLH 201
GKIN+M + + + + T + + + SI+L++E + E + L
Sbjct: 426 GKINKMKNSNYADQFNI-----PTNITTKTHKLSINLLREID---ESVCSESDVFSNTLD 477
Query: 202 TLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET--SGEKSRQLRDA 259
TL E + W+ + L ELN RA D L E + ++ +L+
Sbjct: 478 TLSEIE--------WNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLK 529
Query: 260 QQDARDKMEDIERQVRE------------LKTKISAMKEEKEQLSAERQEQIKQRTKLEL 307
+++ D+ E +ER+ ++ LK + + + L E +++ + E
Sbjct: 530 EKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKED 589
Query: 308 KAKDLQDELAGNSEQRKRLLKERQKLLEKIEE-KQKELAETEPKFNSVKEKEERGIAR-- 364
+ K LQ+ + +S++ + + + LE IE+ KQ + + + ++ K E R
Sbjct: 590 QIKKLQEYI--DSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSE 647
Query: 365 ---LAQATQERTDLYAKQGRG-----SQFTSKEERDKWIKKELKS-------LDQAINDK 409
L + +E Y + SQ +K++ ++KEL+S L I+ K
Sbjct: 648 NLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 707
Query: 410 KRQIAAIHKDLED--TEANKE--KNLEQYNKLDQD---LNEVKARVEELDRKYYEVKNKK 462
+ + +LE T+ KE K +E+ L ++ L+E+K+ E++R E+++K
Sbjct: 708 VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 463 DELQ---SERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHF 519
+EL SE++ L+ E ++ + E++ K + L + S ++ +F
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ-----SNYKSTDQEFQNF 822
Query: 520 RRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKM 579
K ++ + Y ++ N E V ++ + F DS + K + +
Sbjct: 823 --KTLHMDFEQKYKMVLEEN---ERMNQEIVNLSKEAQKF----DSSLGALKTELSYKTQ 873
Query: 580 NLPGEVTFLP--LNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSME 637
L + + LN+++ + + + + KTLI ++
Sbjct: 874 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER---------------EKTLITEKLQ 918
Query: 638 VSTQLARAFTMDCITLEGDQVS---HRGALTGGYYDTRKSRLELQKDVRKA-------EE 687
+ + + T + L+ Q S R L +DT ++ Q+ +R A +E
Sbjct: 919 QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
Query: 688 ELGELEAKLNENLRRNI---ERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKE 744
+ L++K++E + RN+ E D+ +M I+ +Q + ++ +++K E
Sbjct: 979 TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD-NE 1037
Query: 745 KRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEI 804
+Q K F Q L+ L ++ + +E LK +L ++ ++++E+Q+ + L DE+
Sbjct: 1038 IIEQQRKIFSLIQEK-NELQQMLESVIAEKEQLKTDLKENI--EMTIENQEELRLLGDEL 1094
Query: 805 R---------------------------------------QLQQENRQLLNERIKLEGII 825
+ QLQ++ +QLLN
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN--------- 1145
Query: 826 TRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDN 885
V+ ++E ++K+++++E NEL+ E T +E + + + +
Sbjct: 1146 --VQEEMSE-MQKKINEIENLKNELKNKE------LTLEHMETERLELAQKLNENYEEVK 1196
Query: 886 SIDKTEAGIKELQKSMERWKNMEKEHM-------DAINHDTKELEKMTNRQGMLLKKKEE 938
SI K +KELQKS E E++H+ +A TKE K+ + + LK+ +E
Sbjct: 1197 SITKERKVLKELQKSFE----TERDHLRGYIREIEATGLQTKEELKIAH---IHLKEHQE 1249
Query: 939 CMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHV--NKKALDQFVNFSEQ 996
+ ++R S+ ++ + T L++ KL++ L + + N K + + +
Sbjct: 1250 TIDELRR--SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307
Query: 997 KEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSK 1038
E L ++ D + +E+ + K++ Q K ++K
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK 1349
Score = 89.7 bits (221), Expect = 1e-17
Identities = 206/1137 (18%), Positives = 458/1137 (40%), Gaps = 177/1137 (15%)
Query: 2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQR 61
YI+++ G ++ + I +H + S I E SH + ++
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 62 LALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDV 121
+ +LHE LP KE + + + L ++ TK+
Sbjct: 1282 IPVLHE-----------------EQELLPNVKEVSETQETMNELE---LLTEQSTTKDST 1321
Query: 122 MNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKE---ESISL 178
R N + Q +I + D+ LK ++E + +D+ KE E+++
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDN--LKTIKEALEVK-HDQLKEHIRETLAK 1378
Query: 179 MKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDK--MRRALEYTIYNQELNETR 236
++E++ K+E+ + +E+ + + E+ Q++ D +R +E ++ L E+
Sbjct: 1379 IQESQSKQEQSLNM----KEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 237 AKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQ 296
++ ++ +++ L+ Q+ + + + ++ ++E+ K +EE + +
Sbjct: 1435 DEMKSVAKEKD-------DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 297 EQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQ-----KELAETEPKF 351
EQ + +L + + + E++ +Q + + + Q +++I EK+ K+++E + K
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 352 NSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWI--KKELKSLDQAINDK 409
N +K+ +E A+ + + + R + S+EE I K+E+K + +A+ +
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQE--SQEEIQIMIKEKEEMKRVQEALQIE 1605
Query: 410 KRQIAAIHKDLEDTEANKEKNLEQYNKLD--QDLNEVKARVEELDRKYYEVKNKKDELQS 467
+ Q+ K++ ++ Q+ K+ + E +E L ++ K + +++
Sbjct: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
Query: 468 ER---NYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRR-KG 523
E + E E +++ +R+DL ++ L+ + N ++I + L+ K
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKI 1725
Query: 524 INQHVQ------NGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFN 577
++ H++ + GIV E++ + H D+ ++
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTN---------EISNMQKDLEHSNDA--------LKAQ 1768
Query: 578 KMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLR--YNPRFDKAFKHVFGKTLICRS 635
+ + E+ ++ + ++T I KLR + + DK
Sbjct: 1769 DLKIQEELRIAHMHLKEQQET-----------IDKLRGIVSEKTDKLSNMQKDLENSNAK 1817
Query: 636 MEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQ---KDVRKAEEELGEL 692
++ Q +A ITL+ D +T+K E++ K ++ L +L
Sbjct: 1818 LQEKIQELKANEHQLITLKKD-----------VNETQKKVSEMEQLKKQIKDQSLTLSKL 1866
Query: 693 EAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKT 752
E + N NL + + E+ +M + + + K RD LKE Q+++
Sbjct: 1867 EIE-NLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD-------QLKESLQETKAR 1918
Query: 753 FMPKQRSLQSLEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQE 810
+ Q+ L++ + T + L+ ++ T +S + + K D L +I++LQ++
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKK 1978
Query: 811 NRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR--ETEGGTVLTATTSELEA 868
QLL R+K + ++ + E L+K+ + + +R + L + E+
Sbjct: 1979 ELQLL--RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
Query: 869 INKRVKDTMARSEDLDNSIDKTEAGIKEL---QKSMERWKNMEKEHMDAINHDTKELEKM 925
+ K + E L D+ A ++E+ + + K ++ D H T+ L +
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 926 TNRQGMLLKKKE------ECMKKIRELGSLPQEAFEK--------------YQTLSLKQL 965
+R LLK+ EC+ ++ L + F+K QT +++L
Sbjct: 2097 CSRIKELLKRYSEMDDHYECLNRL-SLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKL 2155
Query: 966 FRKLEQCN-----------------TELKKYSH--VNKKALDQFVNFSEQKEKLIK---R 1003
F ++C+ T++K+ H +NK +D +QKE LIK
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Query: 1004 QEELDRGYKSIMEL-------MNVLELRK------YEAIQLTFKQVSKNFSEVFQKL 1047
Q++ D + + +L +++ E+ K + +I+ F+QV N E+ Q L
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFL 2272
Score = 86.3 bits (212), Expect = 2e-16
Identities = 164/857 (19%), Positives = 347/857 (40%), Gaps = 121/857 (14%)
Query: 154 QRLKLLREVAGTRVYDERKEESISL----MKETEGKREKINELLKYIEERLHTLEEEKEE 209
+R +L + T D K+E + + +KE + +K+ ++ + ++++ E
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 210 LAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMED 269
K ++ E I + L E + +D+L R EK+ +L + Q+D +
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKL---RGIVSEKTDKLSNMQKDLENSNAK 1817
Query: 270 IERQVRELKTK----ISAMKE---------EKEQLSAERQEQIKQRTKLELKAKDLQDEL 316
++ +++ELK I+ K+ E EQL + ++Q +KLE++ +L +L
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Query: 317 AGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLY 376
N E+ K ++KER L ++EE K + + +KE + AR + QE
Sbjct: 1878 HENLEEMKSVMKERDN-LRRVEETLK------LERDQLKESLQETKARDLEIQQEL---- 1926
Query: 377 AKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNK 436
+ ++ SKE K+ + L + I++K QI+ I KDL+ ++ +K +++ K
Sbjct: 1927 ----KTARMLSKEH-----KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK 1977
Query: 437 LDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYL-------------WREENAEQQAL 483
+ L VK V +K E++ K + +++ + E E + +
Sbjct: 1978 KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037
Query: 484 AAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECE 543
A +R++L + ++ L+ + I + I + + + K + + +G + E
Sbjct: 2038 AKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT------E 2091
Query: 544 PAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVR---DTAY 600
C + + + + D E ++ ++ K E+ F + V+ Y
Sbjct: 2092 SLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK-----EIEFQKELSMRVKANLSLPY 2146
Query: 601 PETNDAIPMISKL-RYNPRFDKAFKHVFGK-----TLICRSMEVSTQLARAFTMDCITLE 654
+T I KL N R F + K + + + E + F MD I
Sbjct: 2147 LQTKH----IEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI--- 2199
Query: 655 GDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERI-----NN 709
D+V + L LQ+D EL +L KLN+N+ +IE I +
Sbjct: 2200 -DEVEKQKELL-------IKIQHLQQDCDVPSRELRDL--KLNQNMDLHIEEILKDFSES 2249
Query: 710 EIDQLMNQMQQIETQQRKFKASRDSILS---EMKMLKEKRQQSEKTFMPKQRSLQSLEAS 766
E + + QQ+ + +++ + L+ +++ LK Q+ +
Sbjct: 2250 EFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN---- 2305
Query: 767 LHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKL----- 821
+ ES + E + +S+ +D K + N+++ + Q + L ++
Sbjct: 2306 -RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ 2364
Query: 822 EGIITRVETYLNENLRKRLDQVEQELNELRET--EGGTVLTATTSELEAINKRVKDTMAR 879
+ V + + +++ ++E L+E +E+ + + ELE N + A+
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424
Query: 880 SEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAIN-----------HDTKELEKMTNR 928
+ + ++KT+ I+ LQ + KE ++ + + KE EK +
Sbjct: 2425 VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISA 2484
Query: 929 QGMLLKKKEECMKKIRE 945
++ ++E ++ +RE
Sbjct: 2485 TKATVEYQKEVIRLLRE 2501
Score = 85.9 bits (211), Expect = 2e-16
Identities = 144/790 (18%), Positives = 327/790 (41%), Gaps = 102/790 (12%)
Query: 268 EDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLL 327
E+IE ++ L+ + + EQL E++E +ELK K+ D + +RK
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEE-------MELKLKEKNDLDEFEALERKTKK 546
Query: 328 KERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTS 387
+ +L+ +I K L + +N E E ++ + +E+ D K ++
Sbjct: 547 DQEMQLIHEISNL-KNLVKHAEVYNQDLENE---LSSKVELLREKEDQIKKL---QEYID 599
Query: 388 KEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKAR 447
++ + IK +L ++I D K+ + + L D E + L + E+K +
Sbjct: 600 SQKLEN-IKMDLSYSLESIEDPKQ----MKQTLFDAETVALDAKRESAFLRSENLELKEK 654
Query: 448 VEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILN 507
++EL Y +++N QS+ + + ++ L + ++ K L+ K +L
Sbjct: 655 MKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 508 GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDE 567
++ K+ D +K +N+ V+ +++
Sbjct: 715 NLELEGKITD--LQKELNKEVE----------------------------------ENEA 738
Query: 568 VSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVF 627
+ ++++ +LP EV L D + + T++ + S++ + +
Sbjct: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 628 GKTLICRSMEVSTQLARAFT----MDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVR 683
GKT + +TQ T + TL D + + + L K+ +
Sbjct: 799 GKT---KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
Query: 684 KAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK 743
K + LG L+ +L+ + E+ E+ + +N+M+Q++ Q ++ ++ E ++
Sbjct: 856 KFDSSLGALKTELSYKTQELQEK-TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914
Query: 744 EKRQQS---EKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDAL 800
EK QQ+ KT ++ L+ L+ SL + R+ LK+++ + + ++Q L
Sbjct: 915 EKLQQTLEEVKTLTQEKDDLKQLQESL---QIERDQLKSDIHDTVNMNIDTQEQ-----L 966
Query: 801 NDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQEL-----NELRETEG 855
+ + L+Q + + K+ ++R ++ EN + D+ +Q++ + E +
Sbjct: 967 RNALESLKQHQETINTLKSKISEEVSR-NLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 856 GTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMD 913
LTA + E I +++ + +L ++ A ++L+ ++ M E+ +
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
Query: 914 AINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCN 973
+ EL+K +Q ++ ++K +KK E L + +L +
Sbjct: 1086 ELRLLGDELKK---QQEIVAQEKNHAIKKEGE----------------LSRTCDRLAEVE 1126
Query: 974 TELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTF 1033
+LK+ S ++ Q +N E+ ++ K+ E++ + LE + E ++L
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELA- 1185
Query: 1034 KQVSKNFSEV 1043
+++++N+ EV
Sbjct: 1186 QKLNENYEEV 1195
Score = 79.0 bits (193), Expect = 3e-14
Identities = 179/922 (19%), Positives = 385/922 (41%), Gaps = 143/922 (15%)
Query: 192 LLKYIEERLHTLEEEKEEL-----AQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKR 246
LLK + + L+++ EE+ AQ + D++ + LE Q++ K++ L+
Sbjct: 344 LLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE--KIENLTRML 401
Query: 247 ETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRT-KL 305
TS + QQ+ + K + R+V KI+ MK I +T KL
Sbjct: 402 VTSSSLT-----LQQELKAKRK---RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL 453
Query: 306 ELKA-KDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIAR 364
+ +++ + + S+ L ++ K E + NS++ + +
Sbjct: 454 SINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLD 513
Query: 365 LAQATQERTDLYAKQGRGSQFTSKEERDKWIKK--ELKSLDQAINDKK--RQIAAIHKDL 420
Q E+ ++ K + E ++ KK E++ + + N K + ++DL
Sbjct: 514 YEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDL 573
Query: 421 EDTEANKEKNL----EQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREE 476
E+ ++K + L +Q KL + ++ K ++D Y +++ +D Q ++
Sbjct: 574 ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSY-SLESIEDPKQMKQTLF---- 628
Query: 477 NAEQQALAAKRE-------DLEKKQQLLRAATG-KAILNGIDSINKVLDHFRRKGINQHV 528
+AE AL AKRE +LE K+++ AT K + N I L+ ++ ++
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 529 QNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFL 588
E + AF ++T+ ++D +V +L + L G++T L
Sbjct: 689 ------------ELQSAFNEITKLTS-------LIDG-KVPKDLLCN---LELEGKITDL 725
Query: 589 P--LNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAF 646
LNK + A E + ++S+L+ P + + + ++ ++
Sbjct: 726 QKELNKEVEENEALREE---VILLSELKSLPSEVERLR---------KEIQDKSEELHII 773
Query: 647 TMDCITLEGDQVSHRGALTGGYYDTRKSRLEL---QKDVRKAEEELG-------ELEAKL 696
T + L + V + G + K++ +L Q + + ++E + E K
Sbjct: 774 TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833
Query: 697 NENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPK 756
L N ER+N EI L + Q KF +S ++ +E+ ++ Q+ + +
Sbjct: 834 KMVLEEN-ERMNQEIVNLSKEAQ-------KFDSSLGALKTELSYKTQELQEKTREVQER 885
Query: 757 QRSLQSLEASLHAMESTRESLKAE--LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQL 814
++ L+ L +ST ++++ E L T+ L Q +LE+ K + D+++QL QE+ Q+
Sbjct: 886 LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ-TLEEVKTLTQEKDDLKQL-QESLQI 943
Query: 815 LNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVK 874
+++K + +++ + +D EQ N L L + + ++
Sbjct: 944 ERDQLKSD---------IHDTVNMNIDTQEQLRNALES------LKQHQETINTLKSKIS 988
Query: 875 DTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKE------------- 921
+ ++R+ ++ + +T+ ++ +++ +++E ++ + D K+
Sbjct: 989 EEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL 1048
Query: 922 LEKMTNRQGML---LKKKEECMKKIRELGSLPQEAFEKYQTLS---LKQLFRKLEQCNTE 975
+++ Q ML + +KE+ ++E + E E+ + L KQ ++ N
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 976 LKK----------YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRK 1025
+KK + V +K ++ E++++L+ QEE+ K I E+ N+ K
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168
Query: 1026 YEAIQLTFKQVSKNFSEVFQKL 1047
+ +LT + + E+ QKL
Sbjct: 1169 NK--ELTLEHMETERLELAQKL 1188
Score = 72.4 bits (176), Expect = 2e-12
Identities = 171/864 (19%), Positives = 360/864 (41%), Gaps = 131/864 (15%)
Query: 274 VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKL 333
V E+ T + +K ++++ + ++Q+++ LE +A+ ++ + + K LL++ Q
Sbjct: 335 VNEVSTDEALLKRYRKEIM-DLKKQLEE-VSLETRAQAMEKDQLAQLLEEKDLLQKVQN- 391
Query: 334 LEKIEEKQKELAETEPKF--NSVKEKEERGIAR-LAQATQERTDLYAKQGR-GSQFTSKE 389
EKIE + L + +K K +R + L + + + YA Q + T+K
Sbjct: 392 -EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKT 450
Query: 390 ERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVE 449
K L+ +D+++ + + L + E N L ++ +LN ++A +
Sbjct: 451 H--KLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD 508
Query: 450 ELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGI 509
L Y +++ +K+E++ + +E+N + A +R+ KK Q ++ +++ I
Sbjct: 509 NLVLDYEQLRTEKEEMELK----LKEKNDLDEFEALERK--TKKDQEMQ------LIHEI 556
Query: 510 DSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL----------F 559
++ ++ H + NQ ++N V E E E +L
Sbjct: 557 SNLKNLVKH--AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
Query: 560 YHIVDSDEVSTKIL-MEFNKMNLPGEVTFLPLNKLDVRD------TAYPETNDAIPMI-- 610
I D ++ + E ++ E FL L++++ T Y + + I +
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 611 ---SKLRYNPRFDKAFKHVFG--------------KTLICRSMEVS---TQLARAFTMDC 650
+K + +K + F K L+C ++E+ T L + +
Sbjct: 675 QLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC-NLELEGKITDLQKELNKE- 732
Query: 651 ITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRKAEEELGELEA---KLNENLRRNIER 706
+E ++ + + S +E L+K+++ EEL + + KL + R
Sbjct: 733 --VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 707 INNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPK----QRSLQS 762
+ ++++ + T Q +K S D K L +Q K + + + + +
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYK-STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN 849
Query: 763 LEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLE 822
L +S+ +LK E LS + E Q++ + + + +++Q QL N L+
Sbjct: 850 LSKEAQKFDSSLGALKTE-----LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Query: 823 GIITRVETYLNENLRKRLDQVE---QELNELRETEGGTVLTATTSELEAINKRVKDTMAR 879
+ R +T + E L++ L++V+ QE ++L++ + + E + + + DT+
Sbjct: 905 -TVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI-----ERDQLKSDIHDTVNM 958
Query: 880 SEDLDNSIDKTEAGIKELQKSMERWKNMEKE------HMDAINHDTKE--LEKMT---NR 928
+ D + +K+ Q+++ K+ E HM+ +TK+ +KM +
Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018
Query: 929 QGMLLK---------KKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKY 979
Q + K K E +++ R++ SL QE E Q L+ + + EQ T+LK+
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ--MLESVIAEKEQLKTDLKEN 1076
Query: 980 SHV---NKKAL--------DQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEA 1028
+ N++ L Q +++K IK++ EL R + L V E K ++
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR---TCDRLAEVEEKLKEKS 1133
Query: 1029 IQLTFKQ-----VSKNFSEVFQKL 1047
QL KQ V + SE+ +K+
Sbjct: 1134 QQLQEKQQQLLNVQEEMSEMQKKI 1157
Score = 70.5 bits (171), Expect = 9e-12
Identities = 176/934 (18%), Positives = 369/934 (39%), Gaps = 178/934 (19%)
Query: 140 KQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEER 199
K K++ M ++ KL ++ + + + + ET+ K ++ +L K I+++
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ 1859
Query: 200 LHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
TL K E+ K+ LE E+ + D L ET + QL+++
Sbjct: 1860 SLTLS--KLEIENLNLAQKLHENLE------EMKSVMKERDNLRRVEETLKLERDQLKES 1911
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGN 319
Q+ K D+E Q +ELKT KE KE + R E+I ++T ++ D+Q +L +
Sbjct: 1912 LQET--KARDLEIQ-QELKTARMLSKEHKETVDKLR-EKISEKT---IQISDIQKDLDKS 1964
Query: 320 SEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQ 379
++ ++ ++E QK ++ ++++ + K N +++ +++ A+ R D +
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 380 GRGSQFTSK-----EERD--KWIKKELK-SLDQAINDKKRQIAAIHKDLEDTEANKEKNL 431
+ + + +ERD + IK+ LK DQ I + IA +D ++ + EK L
Sbjct: 2025 KKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIA---RDRQNHQVKPEKRL 2081
Query: 432 --EQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKRED 489
+ L + L E +R++EL ++Y E+ + + L D
Sbjct: 2082 LSDGQQHLTESLREKCSRIKELLKRYSEMDD------------------HYECLNRLSLD 2123
Query: 490 LEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGI------NQHVQNGYHGIVMNNFECE 543
LEK+ + + + + N L + + K I NQ +H I M +
Sbjct: 2124 LEKEIEFQKELSMRV------KANLSLPYLQTKHIEKLFTANQRCSMEFHRI-MKKLKYV 2176
Query: 544 PAFYTCV---EVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY 600
++ T + + + N+ +D E ++L++ + +V L L +
Sbjct: 2177 LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMD 2236
Query: 601 PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH 660
+ + S+ + P F+ V +S+
Sbjct: 2237 LHIEEILKDFSESEF-PSIKTEFQQV-------------------------------LSN 2264
Query: 661 RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ 720
R +T + +R +++K ++E N+ + + NN I +MN+ +
Sbjct: 2265 RKEMTQFLEEWLNTRFDIEKLKNGIQKE--------NDRICQVNNFFNNRIIAIMNESTE 2316
Query: 721 IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRE----- 775
E + + ++K LKEK +EK F Q SL + +T++
Sbjct: 2317 FEERSATISKEWE---QDLKSLKEK---NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH 2370
Query: 776 --SLKAELGTDLLSQLS-----------------LEDQKRVDALNDEIRQLQ-------- 808
S +L T+ + +L ++ QK ++ ND I +LQ
Sbjct: 2371 VTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNK 2430
Query: 809 -----QENRQLLNERIKLEGIITRVETYLNENLRKRLDQVE-QELNELRETEGGTVLTAT 862
+E Q+L +++ L + E E+L+ +L +++ +++ +E E T
Sbjct: 2431 CLEKTKETIQVLQDKVALGAKPYKEEI---EDLKMKLVKIDLEKMKNAKEFEKEISATKA 2487
Query: 863 TSELE-AINKRVKDTMARSEDLDNSIDKTE----------------AGIKELQKSMERWK 905
T E + + + +++ + RS+ ++ +E +GI + K++
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL---- 2543
Query: 906 NMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ EH+ KE+ K+ + L+K+K E + + L + + ++ +LK+
Sbjct: 2544 ILKSEHIRL----EKEISKLKQQNEQLIKQKNELLSNNQHLSN----EVKTWKERTLKRE 2595
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEK 999
K C K + + + S+ KE+
Sbjct: 2596 AHKQVTCENSPKSPKVTGTASKKKQITPSQCKER 2629
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 108 bits (270), Expect = 3e-23
Identities = 206/1062 (19%), Positives = 424/1062 (39%), Gaps = 184/1062 (17%)
Query: 160 REVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKM 219
+E+A + E+ +E ++ +TE KR K +EE++ TL +EK +L
Sbjct: 851 KEMANMKEEFEKTKEELA---KTEAKR-------KELEEKMVTLMQEKNDLQ-------- 892
Query: 220 RRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKT 279
L+ L + + D+L + K +++ + +D + ++ + R+L+
Sbjct: 893 ---LQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 949
Query: 280 KISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE 339
+ S +K++ + L + K++ E K K+L +E+AG E +L KE++ L E ++
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 340 KQKELAETEPKFNSV---KEKEERGIARLAQATQERTDL-----YAKQGRGSQFTSKEER 391
+L E K N++ K K E+ + L + ++ L AK+ +E
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069
Query: 392 DKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEEL 451
+ + + L++ + K+ +++ + +ED +A +L + + E++AR+EEL
Sbjct: 1070 TMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQA-------LAIQLQKKIKELQARIEEL 1122
Query: 452 DRKYYEVKNKKDELQSERNYLWRE------------------------ENAEQQALAAKR 487
+ + + + + + +R+ L RE AE Q +
Sbjct: 1123 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 488 EDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFY 547
E+ + + AA K + + + + +D +R + Q ++ + M +
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR--VKQKLEKEKSELKMEINDLASNME 1240
Query: 548 TCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAI 607
T + A ++ D++S E + L E++ + ++
Sbjct: 1241 TVSKAKANFEKMCRTLE-DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKD 1299
Query: 608 PMISKL-RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM---DCITLEGDQVSHRGA 663
M+S+L R F + + + K + + + LA A DC L + A
Sbjct: 1300 AMVSQLSRGKQAFTQQIEEL--KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA 1357
Query: 664 -------LTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE-----------------N 699
++ + + R + + D + EEL E + KL + +
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 700 LRRNIERINNEIDQLMNQMQQ-------IETQQRKFKASRDSILSEMKMLKEKRQQSEKT 752
L + +R+ NE++ LM +++ ++ +QR F D +L+E K E+ Q +
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF----DKVLAEWKQKYEETQAELEA 1473
Query: 753 FMPKQRSL--------QSLEASLHAMESTR---ESLKAELGTDLLSQLSLEDQKRVDALN 801
+ RSL + E SL +E+ + ++L+ E+ +DL Q++ E K + L
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEI-SDLTEQIA-EGGKHIHELE 1531
Query: 802 DEIRQLQQENRQLLNERIKL-------EGIITRVETYLNE---NLRKRLDQVEQELNELR 851
+QL E +L + EG I R++ LN+ + +++ + ++EL++L+
Sbjct: 1532 KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK 1591
Query: 852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTE-----------AGIKELQKS 900
V+ + S L+A + D + + ++ +++ E ++ L+ +
Sbjct: 1592 RNH-LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT 1650
Query: 901 MERWKNMEKEHMDAI--NHDTKELEKMTNRQGMLLK----------KKEECMKKIRELGS 948
K+ + DAI D KE M R+ L++ ++ E +K+ E
Sbjct: 1651 QGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQEL 1710
Query: 949 LPQEAFEKYQTL----------------SLKQLFRKLEQCNTELKKYSHVNKKALDQFVN 992
L +A E+ Q L + Q+ ++E E + KKA+
Sbjct: 1711 L--DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM 1768
Query: 993 FSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGK 1052
+E+ +K L+R K++ + + L+LR EA QL K GGK
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK---------------GGK 1813
Query: 1053 ATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFT 1094
+ + V +S+ E E E G + V + T
Sbjct: 1814 KQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELT 1855
Score = 107 bits (267), Expect = 7e-23
Identities = 208/960 (21%), Positives = 405/960 (42%), Gaps = 133/960 (13%)
Query: 143 KINQMATAPDSQRLKLLREVAG-----TRVYDERK---EESISLMKETEGKREKINELLK 194
K+ + A +++ L E+AG ++ E+K E + + + + +K+N L K
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTK 1026
Query: 195 Y---IEERLHTLE---EEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET 248
+E+++ LE E++++L + K + + + + +T +L+ K +
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKK 1086
Query: 249 SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELK 308
+ L+ +D + ++++++EL+ +I ++EE E A R + KQR+
Sbjct: 1087 KEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS----- 1141
Query: 309 AKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQA 368
DL EL SE RL + +IE +K AE + ++E + A A
Sbjct: 1142 --DLSRELEEISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196
Query: 369 TQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE 428
++ D A+ G Q S + + ++KE L IND + + K +AN E
Sbjct: 1197 RKKHADSVAE--LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK----AKANFE 1250
Query: 429 KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAE--------- 479
K L+ L+E+K + EE R E+ +K L +E R+ + +
Sbjct: 1251 K---MCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 480 -QQALAAKREDLEKKQQLLRAATGKAIL-NGIDSINKVLDHFRRKGINQHVQNGYHGIVM 537
+QA + E+L K+QL K+ L + + S D R + + M
Sbjct: 1308 GKQAFTQQIEEL--KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 538 NNFECEPAFYTCVEVT-----------AGNRLFYHIVDSDE----VSTKIL-MEFNKMNL 581
+ E A + T A +L + D++E V++K +E K L
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 582 PGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKA---FKHVFGKTLICRSMEV 638
EV L +DV +N A + K + N FDK +K + +T +E
Sbjct: 1426 QNEVEDL---MIDVE-----RSNAACIALDKKQRN--FDKVLAEWKQKYEETQ--AELEA 1473
Query: 639 STQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRKAEEELGELEAKLN 697
S + +R+ + + ++ Y+ LE L+++ + ++E+ +L ++
Sbjct: 1474 SQKESRSLSTELFKVK------------NAYEESLDHLETLKRENKNLQQEISDLTEQIA 1521
Query: 698 ENLR--RNIERINNEIDQLMNQMQ-QIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFM 754
E + +E++ ++D +++Q +E + + IL L + + + ++
Sbjct: 1522 EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIA 1581
Query: 755 PKQRSLQSLEAS-LHAMESTRESLKAELGTDLLSQLSLEDQKRVDA-LNDEIRQLQQENR 812
K L L+ + L +ES + +L AE+ + +L +K+++ LN+ QL NR
Sbjct: 1582 EKDEELDQLKRNHLRVVESMQSTLDAEIRS---RNDALRIKKKMEGDLNEMEIQLNHANR 1638
Query: 813 Q---LLNERIKLEGIITRVETYLNENLR-------------KRLDQVEQELNELR----E 852
Q L +GI+ + +L++ +R +R + ++ E+ ELR
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698
Query: 853 TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSME----RWKNME 908
TE G + EL ++RV+ ++ L N+ K E I ++Q ME +N E
Sbjct: 1699 TERGRKM--AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756
Query: 909 KEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQL 965
++ AI +EL+K + L + K+ + +++L EA E+ K+
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA-EQLALKGGKKQ 1815
Query: 966 FRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR---QEELDRGYKSIMELMNVLE 1022
+KLE EL+ +K + V + E+ +K Q E DR K+I+ L ++++
Sbjct: 1816 IQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDR--KNILRLQDLVD 1873
Score = 84.3 bits (207), Expect = 6e-16
Identities = 162/834 (19%), Positives = 340/834 (40%), Gaps = 124/834 (14%)
Query: 196 IEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQ 255
I+ L + E EKE ++++K + +EL +T AK EL K T ++
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTK---------EELAKTEAKRKELEEKMVTLMQEKN- 889
Query: 256 LRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDE 315
D++ QV+ ++ +E +QL IK + +LE K K++ +
Sbjct: 890 -------------DLQLQVQAEADALADAEERCDQL-------IKTKIQLEAKIKEVTER 929
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAE--------------TEPKFNSVKEKEERG 361
E L +++KL ++ E +K++ + TE K ++ E+
Sbjct: 930 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
Query: 362 IARLAQATQERTDLY-AKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL 420
+A+ T+E+ L A Q +E++ + K L+Q ++D + + K
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC 1049
Query: 421 EDTEANKEK-----NLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475
D E K K L Q + +D + N+ + E+L +K +E+ N + +++ E+ L +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTE-NDKQQLNEKLKKKEFEMSNLQGKIEDEQ-ALAIQ 1107
Query: 476 ENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGI 535
+ + L A+ E+LE++ + RA+ KA D +++ L+ I++ ++
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSRELEE-----ISERLE------ 1155
Query: 536 VMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDV 595
E T ++ + + K+ + + L E T L K
Sbjct: 1156 -------EAGGATSAQIEMNKK-------REAEFQKMRRDLEESTLQHEATAAALRKKHA 1201
Query: 596 RDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEG 655
A E + I + +++ +K+ + L +ME ++ F C TLE
Sbjct: 1202 DSVA--ELGEQIDSLQRVKQKLEKEKSELKMEINDL-ASNMETVSKAKANFEKMCRTLE- 1257
Query: 656 DQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNE------NLRRNIERINN 709
DQ+S + + ++ EL + E GE +L+E L R +
Sbjct: 1258 DQLSE---IKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314
Query: 710 EIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASL-- 767
+I++L Q+++ + + S + +L+E+ ++ ++ QR + + +
Sbjct: 1315 QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 768 ----HAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEG 823
+ ++ + + + E L+Q + ++ V+A+N + L++ ++L NE +E
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNE---VED 1431
Query: 824 IITRVE-----TYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMA 878
++ VE + ++ D+V E + E T +ELEA K++ +
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQKYE--------ETQAELEASQ---KESRS 1480
Query: 879 RSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMD---AINHDTKELEKMTNRQGMLLKK 935
S +L + E + L+ KN+++E D I K + ++ + L +
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 936 KEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQ 989
K E + E EA +++ + ++ +L Q +E+ + + LDQ
Sbjct: 1541 KSELQTSLEE-----AEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQ 1589
Score = 72.4 bits (176), Expect = 2e-12
Identities = 124/663 (18%), Positives = 276/663 (41%), Gaps = 91/663 (13%)
Query: 173 EESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEY--TIYNQ 230
E+ +S +K E +++++ L + RLHT E E Q + D M L + Q
Sbjct: 1257 EDQLSEIKTKEEEQQRLINELSAQKARLHT--ESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314
Query: 231 ELNETRAKLDELSAKRETSGEKSRQ-------LRDAQQDARDKMEDIERQVRELKTKISA 283
++ E + +L+E + + T + LR+ ++ ++ +++R + + ++++
Sbjct: 1315 QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 284 MKEEKEQLSAERQEQIKQ-RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQK 342
+ + E + +R E++++ + KL + +D ++ + + + L K +Q+L ++E+
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMI 1434
Query: 343 ELAETEPKFNSVKEKEERGIARLAQATQE----RTDLYAKQGRGSQFTSK---------E 389
++ + ++ +K+ LA+ Q+ + +L A Q +++ E
Sbjct: 1435 DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE 1494
Query: 390 ERD--KWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKAR 447
D + +K+E K+L Q I+D QIA K + + E K++ + ++L L E +A
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554
Query: 448 VE------------------ELDRKYYEVKNKKDEL--------QSERNYLWREENAEQQ 481
+E E+DRK E + D+L +S ++ L E +
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRND 1614
Query: 482 ALAAKRE---DLEKKQQLLRAATGKAI-----------------------LNGIDSINKV 515
AL K++ DL + + L A +A + G D + +
Sbjct: 1615 ALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQ 1674
Query: 516 LDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL-FYHIVDSDEVSTKILM 574
L R+ + + E + A R+ H ++ ++TK +
Sbjct: 1675 LAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL 1734
Query: 575 EFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICR 634
E + + GE+ + + + A DA M +L+ + A K +
Sbjct: 1735 ETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNMEQT 1793
Query: 635 SMEVSTQLARAFTMDCITLEGD--QVSHRGA----LTGGYYDTRKSRLELQKDVRKAEEE 688
++ +L A + + L+G Q+ A L +K +E K +RK E
Sbjct: 1794 VKDLQLRLDEA---EQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERR 1850
Query: 689 LGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQ 748
+ EL + E+ R+NI R+ + +D+L +++ + Q + + + L++ + L+ + ++
Sbjct: 1851 VKELTYQTEED-RKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEE 1909
Query: 749 SEK 751
+++
Sbjct: 1910 AKE 1912
Score = 66.6 bits (161), Expect = 1e-10
Identities = 123/592 (20%), Positives = 246/592 (41%), Gaps = 78/592 (13%)
Query: 670 DTRKSRLELQKDVRKAEEELGELEAK---LNENLRRNIERINN----------------- 709
+T K ++++ K +EEL + EAK L E + ++ N+
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 710 EIDQLMNQMQQIETQQRKFKASRD-------SILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
DQL+ Q+E + ++ + + ++ + L+++ + +K + +L
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 763 LEASLHAMESTRESLKAELG--TDLLSQLSLEDQKRVDALNDEIRQLQQEN---RQLLNE 817
+E HA E+ ++L E+ + +++L+ E + +A + LQ E L
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 818 RIKLEGIITRVETYLNE--NLRKRLDQVEQEL-NELRETEGGTVLTATTSELEAINKRVK 874
+ KLE + +E L + L L++ +++L +L+ + T+ T ++ + +N+++K
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTM--DTENDKQQLNEKLK 1085
Query: 875 DTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLK 934
+L I+ +A +LQK ++ + +E + I + K ++ L +
Sbjct: 1086 KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 935 KKEECMKKIRELGSLPQEAFE--KYQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQFV 991
+ EE +++ E G E K + +++ R LE+ + + + + KK D
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVA 1205
Query: 992 NFSEQ-------KEKLIKRQEELDRGYKSIMELMNVLELRK--YEAIQLTFK-QVS--KN 1039
EQ K+KL K + EL + M + K +E + T + Q+S K
Sbjct: 1206 ELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT 1265
Query: 1040 FSEVFQKLV---PGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGV 1096
E Q+L+ KA L + G E S+ DE + S+ G Q
Sbjct: 1266 KEEEQQRLINELSAQKARLHTESG--EFSRQLDEKDAM-VSQLSRGKQ------------ 1310
Query: 1097 GIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKA 1156
+FT + E++ + KS +A AL A CD E +Q A+ ++
Sbjct: 1311 ----AFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQY--EEEQEAKAELQRG 1364
Query: 1157 VSDMIMELAV-HAQFITTTF-RPELLESADKFYGVKFRNKVSHIDVITAEMA 1206
+S E+A ++ T R E LE A K + ++ H++ + ++ A
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCA 1416
Score = 64.3 bits (155), Expect = 7e-10
Identities = 87/365 (23%), Positives = 160/365 (43%), Gaps = 55/365 (15%)
Query: 108 QYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQM------ATAPDSQRLKLLRE 161
Q LD ++ ++ND + + + +G +N+M A ++ L+ LR
Sbjct: 1602 QSTLDAEIRSRNDALRIKKKM------------EGDLNEMEIQLNHANRQAAEALRNLRN 1649
Query: 162 VAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEEL-AQYQKWDKMR 220
G K+ + L G+ + + E L +E R + ++ E EEL A ++ ++ R
Sbjct: 1650 TQGIL-----KDTQLHLDDAIRGQ-DDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 221 RALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTK 280
+ E QEL + ++ L + + ++L + +MEDI ++ R + K
Sbjct: 1704 KMAE-----QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEK 1758
Query: 281 I-------SAMKEE--KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQ 331
+ M EE KEQ ++ E++K+ +E KDLQ L E + LK +
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKN--MEQTVKDLQLRL---DEAEQLALKGGK 1813
Query: 332 KLLEKIEEKQKEL---AETEPKFN--SVK--EKEERGIARLAQATQE-RTDLYAKQGRGS 383
K ++K+E + +EL E+E K N +VK K ER + L T+E R ++ Q
Sbjct: 1814 KQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1873
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
+ +K K K++ + ++ N + + +LE+ + + Q NKL E
Sbjct: 1874 KLQTKV---KAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930
Query: 444 VKARV 448
V +V
Sbjct: 1931 VHTKV 1935
Score = 34.3 bits (77), Expect = 0.74
Identities = 37/207 (17%), Positives = 88/207 (42%), Gaps = 16/207 (7%)
Query: 141 QGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERL 200
QG++ + + K + + + E ++ E ++ + + +K ++ RL
Sbjct: 1742 QGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1801
Query: 201 HTLEEEKEELA------QYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSR 254
+E E+LA Q QK + R LE + +++ + A +R +
Sbjct: 1802 ----DEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRV-----K 1852
Query: 255 QLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQD 314
+L ++ R + ++ V +L+TK+ A K + E+ + + + KL+ + ++ ++
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKE 1912
Query: 315 EL-AGNSEQRKRLLKERQKLLEKIEEK 340
S+ K +K R+ + I E+
Sbjct: 1913 RADIAESQVNKLRVKSREVHTKVISEE 1939
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 108 bits (269), Expect = 4e-23
Identities = 191/897 (21%), Positives = 390/897 (43%), Gaps = 134/897 (14%)
Query: 152 DSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELA 211
DSQ L L + ++ KE+ + L+KE+E + +++E E+L+ + + L
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEKEL-LVKESESLQARLSES---DYEKLNVSKALEAALV 2098
Query: 212 QYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIE 271
+ K AL + +E+++ R +++L + E +K Q +K+++ E
Sbjct: 2099 E-----KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK-------QLHIAEKLKERE 2146
Query: 272 RQVRELKTKISAMKEEKEQLSAERQEQI---KQRTKLELKAKDLQDELAGNSEQ-----R 323
R+ LK K+ ++ E Q+S E QE + + +K E++ Q E S +
Sbjct: 2147 RENDSLKDKVENLEREL-QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDL 2205
Query: 324 KRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGS 383
L E++ L ++I+EKQ +L+E + +S K E +E+ ++ K+
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE---------KEQAEIQIKE---- 2252
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
+ + ++ +LK L++A+ + + ++ TE + + +E+ ++L + +
Sbjct: 2253 ---ESKTAVEMLQNQLKELNEAV----AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYL-WREENAEQQALAAKRED----LEKKQQLLR 498
++AR+E ++K V + E + + L R EN E++ A+ LE +
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 499 AATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL 558
T KA + G+ + L+ I +N + N + E + +E+ N
Sbjct: 2366 VETLKAKIEGMTQSLRGLE-LDVVTIRSEKEN-----LTNELQKEQERISELEII--NSS 2417
Query: 559 FYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPR 618
F +I+ E K+ M+ K + E+ L +L+ R A +A
Sbjct: 2418 FENILQEKE-QEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEA------------ 2463
Query: 619 FDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLEL 678
C++ E + + ++C+ LE Q L G + + + + L
Sbjct: 2464 --------------CKAKEQNL----SSQVECLELEKAQ------LLQGLDEAKNNYIVL 2499
Query: 679 QKDVRKAEEELGELEAKLNENLRRNIERINNEI---DQLMNQMQQIETQQRKFKASRDSI 735
Q V +E+ + + KL E I R+ N+I +QL++++ Q+E + + +K
Sbjct: 2500 QSSVNGLIQEVEDGKQKL-EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN--- 2555
Query: 736 LSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQK 795
E++ L + +Q + K SLQ +L ++S+ ++L+ EL + ++S +
Sbjct: 2556 -LELRNLTVELEQKIQVLQSKNASLQD---TLEVLQSSYKNLENELELTKMDKMSFVE-- 2609
Query: 796 RVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEG 855
+V+ + + +LQ+E ++ + +L+ ++ + L L+ L++++ ++L+E
Sbjct: 2610 KVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE--- 2666
Query: 856 GTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAI 915
LT SEL K+ D M + + ++K +E+ + R EK+H +
Sbjct: 2667 ---LTLENSEL----KKSLDCMHKDQ-----VEKEGKVREEIAEYQLRLHEAEKKHQALL 2714
Query: 916 NHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTE 975
K+ E L KEEC+ + L + + E+ SLK + LE E
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNN-SLKATTQILE----E 2769
Query: 976 LKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVL--ELRKYEAIQ 1030
LKK N K ++Q ++ E+ + + L + K + E +L EL + +A Q
Sbjct: 2770 LKKTKMDNLKYVNQ---LKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQ 2823
Score = 97.8 bits (242), Expect = 5e-20
Identities = 175/866 (20%), Positives = 363/866 (41%), Gaps = 110/866 (12%)
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEK 288
NQEL R K++EL + + ++ + + Q+ + ++E + ++ E + ++ ++E
Sbjct: 287 NQEL---RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL 343
Query: 289 EQLSAERQEQIKQRTKLELKAKDLQDELA---GNSEQRKRLLKERQKLLEKIEEKQKELA 345
+ +A+ + + T LE K K L ++L+ N+E + L+ QK+ EK +E Q+EL+
Sbjct: 344 VRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE--QKIKEKEKEFQEELS 401
Query: 346 ETEPKFNSVKEKEERGIARLAQATQERTDLY-AKQGRGSQFTSK----EERDKWIKKELK 400
+ F ++ ++ + ARL Q Q+ +++ Q + TS E + K++L
Sbjct: 402 RQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLC 461
Query: 401 SLDQAI-------NDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDR 453
+QA N+ +R + + K+ +++ E+ + L+ +L +K + +
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 454 KYYEVKNKKDELQSERNYLWREENAEQQALAAKR-----EDLEKKQQLLRAATGKAILNG 508
E+K K ++ L + N ++ +L ++ DLEK++ + K +
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE-HH 580
Query: 509 IDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEV 568
I+ +N L ++ +++ E + Y E + + S+
Sbjct: 581 IEQLNDKLSKTEKES----------KALLSALELKKKEY---EELKEEKTLFSCWKSENE 627
Query: 569 STKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFG 628
ME K NL ++ L L + E N+ + + R N + H
Sbjct: 628 KLLTQMESEKENLQSKINHLE-TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH--- 683
Query: 629 KTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEE 688
L +S+EV TQ ++++ + +K + E++ K +
Sbjct: 684 NVLDSKSVEVETQ---------------KLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 689 LGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKML--KEKR 746
G++E +L ++ ++NEI M++ + + ++++ RD + S+ L E
Sbjct: 729 TGQVE-----DLEHKLQLLSNEI---MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 747 QQS-------------------EKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
Q+S E+ MP +RS E L A +S + S + D L
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERS----ECRLEADQSPKNSAILQNRVDSL- 835
Query: 788 QLSLEDQKRVDA-LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQE 846
+ SLE QK++++ L + +L Q ++ +K E + ++ + K +
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 847 LNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKN 906
N + ET + L EL+ +N +V+ A ++L S E +KELQ E
Sbjct: 896 QNVVAETL--SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
Query: 907 MEKEHMDAINHDTKELEKMTNRQGML----LKKKEECMKKIRELGSLPQEAFEKYQTLSL 962
+KE I+ + +E+E++T G L +E M I++ E+F Y +
Sbjct: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQK-----SESFANY----I 1004
Query: 963 KQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIM-ELMNVL 1021
+ + + + + + K+ + + ++ N E + K +E + + ++ E ++
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1022 ELRKYEAIQLTFKQVSKNFSEVFQKL 1047
E RK E QL + +K E KL
Sbjct: 1065 ENRKNELEQLK-EAFAKEHQEFLTKL 1089
Score = 90.5 bits (223), Expect = 9e-18
Identities = 179/952 (18%), Positives = 393/952 (41%), Gaps = 98/952 (10%)
Query: 166 RVYDERKEESISLMKETE---GKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRA 222
+V D KE + + E ++ I Y+E L ++ EK L + + +K +
Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE-NKQKVI 1946
Query: 223 L----EYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELK 278
+ E ++ E N+ R +LD +S K + S ++++ Q+ + ++ +
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 279 TKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNS-------EQRKRLLKERQ 331
++ E + LS++ E +K +T L+ K + L+ + S Q +L KE++
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 332 KLLEKIEEKQKELAETE-PKFNSVKEKE----ERG-IARLAQATQERTDLYAK--QGRGS 383
L+++ E Q L+E++ K N K E E+G A +TQE + +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV 2126
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNE 443
+ + E++ I ++LK ++ + K ++ + ++L+ +E N+E + ++
Sbjct: 2127 RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVET 2186
Query: 444 VKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ-------QALAAKREDLEKKQQL 496
+K ++EE+ R + L+SE+ L ++ +Q + L++ + LE+K+Q
Sbjct: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
Query: 497 ---LRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVT 553
++ + A+ + + ++ + +Q + + E E +E
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE-- 2304
Query: 554 AGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKL 613
+L + ++ +L + + ++ + L+ R+ TN +
Sbjct: 2305 ---KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-RELEIARTNQEHAALEAE 2360
Query: 614 RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRK 673
+ + G T R +E +D +T+ ++ + L R
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLE----------LDVVTIRSEKENLTNELQ--KEQERI 2408
Query: 674 SRLEL-----QKDVRKAEEELGELEAKLN---ENLRRNIERINNEIDQLMNQMQQIETQQ 725
S LE+ + +++ E+E +++ K + E L+ ++ +N + L N + + ++
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
Query: 726 RKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESL--KAELGT 783
+ + + + E L + +++ ++ Q S+ L + +E ++ L K E +
Sbjct: 2469 QNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL---IQEVEDGKQKLEKKDEEIS 2525
Query: 784 DLLSQLSLEDQ--KRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLD 841
L +Q+ ++Q ++ + E + +++N +L N ++LE I +++ N +L+ L+
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS-KNASLQDTLE 2584
Query: 842 QVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSM 901
++ L E E S +E +NK ++ KT +EL
Sbjct: 2585 VLQSSYKNL-ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 902 ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK------------IRELGSL 949
R + ++ I +L+++T + LKK +CM K I E
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELT-LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR 2702
Query: 950 PQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQK---EKLIKRQEE 1006
EA +K+Q L L +Q E++ Y +K + S QK + L +EE
Sbjct: 2703 LHEAEKKHQAL----LLDTNKQYEVEIQTY---REKLTSKEECLSSQKLEIDLLKSSKEE 2755
Query: 1007 LDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMK 1058
L+ K+ +++ EL+K + L + K +E Q GK L++K
Sbjct: 2756 LNNSLKATTQILE--ELKKTKMDNLKYVNQLKKENERAQ-----GKMKLLIK 2800
Score = 85.1 bits (209), Expect = 4e-16
Identities = 166/902 (18%), Positives = 358/902 (39%), Gaps = 93/902 (10%)
Query: 183 EGKREKIN---ELLKYIEERLHTLEEEKEEL----AQYQKWDKMRRALEYTIYNQELNET 235
E +EK N E K +E + L+ +K A D R ++++ + +T
Sbjct: 165 EDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKT 224
Query: 236 RAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKI---SAMKEEKEQLS 292
+ L S + + S +Q+ ++ R+ + S+ +QL
Sbjct: 225 PSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLK 284
Query: 293 AERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN 352
A+ QE L K +L+ L G+ ++ K + + Q+L ++E+ + EL E E N
Sbjct: 285 AQNQE-------LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 353 SVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQ 412
+++ R A+ QA+ + T L K + ++ S + ++ + SL+Q I +K+++
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKEKE 395
Query: 413 IAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYL 472
+ + + LDQ+ ++KAR L ++ + KN + LQ+E + L
Sbjct: 396 F----------QEELSRQQRSFQTLDQECIQMKAR---LTQELQQAKNMHNVLQAELDKL 442
Query: 473 WREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGY 532
+ + L ++ L + +Q +A+ K + + + ++ +++ N +++
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKE-----NELRRSMEEMKKE--NNLLKSHS 495
Query: 533 HGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNK 592
E + ++ F + + S + ++ + + + L L K
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 593 LDVRDTAYPETNDAIPMISKLR------YNPRFDKAFKH--VFGKTLICRSMEVSTQLAR 644
L + + D + K R N + K K L + E
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 645 AFTMDCITLEGDQVSHRGALTGGYYDTRKSRLEL-----QKDVRKAEEELGELEAKLNEN 699
C E +++ + ++ + LE Q + E + LE EN
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD-REN 674
Query: 700 LRRNIERINNEIDQ-----------LMNQMQQIETQQRKFKASRDS-------ILSEMKM 741
L I ++N +D M Q+ E +K + ++ + +++
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
Query: 742 LKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALN 801
L+ K Q M K R Q L A ++ +S A L T+ Q SL + A++
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 802 DEIRQLQQENRQLLNER--IKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
+ E + +ER +LE + + + L+ R+D +E L ++ L
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAI---LQNRVDSLEFSLESQKQMNSD--L 849
Query: 860 TATTSELEAINKRVKDTMARSEDLDNS-IDKTEAGIKELQKSMERWKNMEKEHMDAINHD 918
EL I +++ + ++E + S + +T I +LQ+ +N+ E + A+ +
Sbjct: 850 QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909
Query: 919 TKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCN----- 973
KEL+ + ++ ++ ++ ++++++ L +++ ++ Q LS K E +
Sbjct: 910 EKELQLLNDK----VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 974 -TELKKYSHVNKKALDQFVNFSEQKEKLIKRQEE----LDRGYKSIMELMNVLELRKYEA 1028
E+++ + N + + +++K LI++ E +D KSI EL + + K
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 1029 IQ 1030
+Q
Sbjct: 1026 LQ 1027
Score = 85.1 bits (209), Expect = 4e-16
Identities = 200/987 (20%), Positives = 406/987 (41%), Gaps = 137/987 (13%)
Query: 180 KETEGKREKINELLKYIEE-RLHTLEEEK------EEL----AQYQKWDKMRRALEYTIY 228
KE +G+ K EL +E+ ++ +E+EK +EL AQY + + +YT
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ-----ASTKYTAL 360
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDA-QQDARDKMEDIERQVRELKTKISAMKEE 287
Q+L + ++LS +R+ + L ++ ++ E++ RQ R +T +
Sbjct: 361 EQKLKKLT---EDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417
Query: 288 KEQLSAERQEQIKQRTKLEL---KAKDLQDELAGNSEQRKRLLKERQK-----------L 333
K +L+ E Q+ L+ K ++ +L N E+ K+ L ++ L
Sbjct: 418 KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL 477
Query: 334 LEKIEEKQKE----LAETEPKFNSV--KEKEERGIARLAQATQERTDLYAKQGRGSQFTS 387
+EE +KE + +E K V E E + I + +Q + + +
Sbjct: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 388 KEERDKWIKKE----LKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYN-KLDQDLN 442
++ ++K ++E L+ L A+ D ++Q +D +E ++EQ N KL +
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQ----RDCSQDLLKKREHHIEQLNDKLSKTEK 593
Query: 443 EVKARVEELDRKYYEVKNKKDELQSERNYL--WREENAE-QQALAAKREDLEKKQQLLRA 499
E KA + L+ K K + +EL+ E+ W+ EN + + +++E+L+ K L
Sbjct: 594 ESKALLSALELK----KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 500 ATGKAILNGIDSINKVLD-HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL 558
+ + +V R+ ++ ++N ++ + + E E +E+
Sbjct: 650 CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Query: 559 FYHIVDSDEVSTKIL--MEFNKMNLPGEVTFLP------LNKLDVRDTAYPETNDAIPMI 610
SD+ K + M L G+V L N++ +D Y + + +
Sbjct: 710 ------SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL 763
Query: 611 SKLRYNPRFDKAFKHVFGKTLICRSME----------VSTQLARAFTMDCITLEGDQVSH 660
L + ++L+ + + Q + LE DQ
Sbjct: 764 RDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPK 823
Query: 661 RGALTGGYYDTRKSRLELQK----DVRKAEEELGELEAKLNENLRRNIERINN----EID 712
A+ D+ + LE QK D++K EEL +++ ++ ENL + E+++ E
Sbjct: 824 NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK-AEQMHQSFVAETS 882
Query: 713 QLMNQMQQIETQQRKFKASRDSIL----SEMKMLKEKRQQSEKTFMPKQRSLQSLEASLH 768
Q ++++Q+ + + A S L E+++L +K + + ++S LE SL
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 769 AMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRV 828
++ E+L E ++ S +SL +++ ++ L E L++ N L E++ L I +
Sbjct: 943 ELQLLSETLSLE-KKEMSSIISL-NKREIEELTQENGTLKEINASLNQEKMNL---IQKS 997
Query: 829 ETYLNENLRKRLDQVEQELNELRETEGGTVL------TATTSELEAINKRVKDTMARSED 882
E++ N +D+ E+ ++EL + L T + E ++++ K ++
Sbjct: 998 ESFAN-----YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSK 1052
Query: 883 LDNSIDKTEAGIKELQKSMERWKN-MEKEHMDAI--------NHDTKELEKMTNRQGMLL 933
L+ +++ + + + +E+ K KEH + + + LE T +Q +
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS 1112
Query: 934 KKKEECMKKIRELGSLPQEAFE-KYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVN 992
+ + E G L QE K + +++ L Q N +L K K + N
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKV----MKTKHECQN 1168
Query: 993 FSEQKEKLIKRQEELDR---GYKSIMEL-MNVLELRKYEA------IQLTFKQVSKNFSE 1042
+ + ++ E +R +K M+L + + L Y A L K++ SE
Sbjct: 1169 LESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESE 1228
Query: 1043 VFQKLVPGGKATLVMKKGDVEGSQSQD 1069
++ + T+ +GD+E S QD
Sbjct: 1229 KEKECLQHELQTI---RGDLETSNLQD 1252
Score = 72.0 bits (175), Expect = 3e-12
Identities = 87/432 (20%), Positives = 184/432 (42%), Gaps = 49/432 (11%)
Query: 83 DNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQG 142
+N N L ++E +S +I + + +K+ + + + E + + +K+
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQ----EKVQMKEKSSTAMEMLQTQLKEL 2450
Query: 143 KINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGK------REKINELLKYI 196
A D + K + ++V E++ L E K + +N L++ +
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510
Query: 197 EERLHTLEEEKEELA----QYQKWDKMRRAL-----EYTIYNQELNETRAKLDELSAKRE 247
E+ LE++ EE++ Q Q +++ L E+ ++ ++ E R EL K +
Sbjct: 2511 EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQ 2570
Query: 248 TSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLEL 307
K+ L+D + + +++E ++ K + E+ +++A+ E ++ ++
Sbjct: 2571 VLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ 2630
Query: 308 KAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE------------------P 349
K +LQ+EL+G ++ RL E Q LLE+I+ + +L E
Sbjct: 2631 KTAELQEELSG---EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVE 2687
Query: 350 KFNSVKEKEERGIARLAQATQERTDLYAK---------QGRGSQFTSKEERDKWIKKELK 400
K V+E+ RL +A ++ L Q + TSKEE K E+
Sbjct: 2688 KEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 401 SLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
L + + + A + LE+ + K NL+ N+L ++ + +++ L + +++
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
Query: 461 KKDELQSERNYL 472
+K+ LQ E + L
Sbjct: 2808 EKEILQKELSQL 2819
Score = 67.8 bits (164), Expect = 6e-11
Identities = 88/389 (22%), Positives = 182/389 (46%), Gaps = 65/389 (16%)
Query: 140 KQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINE-------- 191
KQG+++++ S + LL E + + KEES + ++ + + +++NE
Sbjct: 2222 KQGQLSELDKLLSSFK-SLLEEKEQAEI--QIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
Query: 192 --LLKYIEERLHTLEEEKEELAQYQKWDKMRRALE-----YTIYNQELNETRAKLDELSA 244
++K E+ L EE+ +L +K+R LE Q+L E+ D L
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRN--SIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG 2336
Query: 245 KRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAM--------------KEEKEQ 290
+ E + R Q+ A + E+ + +V LK KI M + EKE
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
Query: 291 LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPK 350
L+ E Q++ ++ ++LE+ ++ +L+E+++ EK++ K+K E
Sbjct: 2397 LTNELQKEQERISELEIINSSFEN-----------ILQEKEQ--EKVQMKEKSSTAMEML 2443
Query: 351 FNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKK 410
+KE E R+A ++ AK+ S E +K + L+ LD+A N+
Sbjct: 2444 QTQLKELNE----RVAALHNDQEACKAKEQNLSSQVECLELEK--AQLLQGLDEAKNNYI 2497
Query: 411 RQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERN 470
++++ +++ E K+K K D++++ +K ++++ + ++ +K +++ E +
Sbjct: 2498 VLQSSVNGLIQEVEDGKQK----LEKKDEEISRLKNQIQDQE----QLVSKLSQVEGE-H 2548
Query: 471 YLWREENAEQQALAAKREDLEKKQQLLRA 499
LW+E+N E + L +LE+K Q+L++
Sbjct: 2549 QLWKEQNLELRNLTV---ELEQKIQVLQS 2574
Score = 67.0 bits (162), Expect = 1e-10
Identities = 168/852 (19%), Positives = 330/852 (38%), Gaps = 154/852 (18%)
Query: 269 DIERQVRELKTKISAMKEEKEQLSAERQEQIKQ-------RTKLELKA-----KDLQDEL 316
++E+ V ELK + S + E+ E S + QE +++ + LE+ A +D+ D +
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886
Query: 317 AGNSEQRKRLLKERQKLLEKIE-------------EKQKELAETE----PKFNSVKEK-- 357
A ++ K + + L +I E E+ +TE K N K+K
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVI 1946
Query: 358 ---EERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLD----QAINDKK 410
EE ++ Q R +L + + E+ K +EL+S I +
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 411 RQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERN 470
++ + L+ ++ + L+ L + L ++ + L E++N+ +L E+
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 471 YLWREENAEQQALAAKREDLEKKQQLLRAA---TGKAILNGIDSINKVLDHFRRKGINQH 527
L +E + Q L+ + + L AA G+ L + +V H R+GI +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEV--HQLRRGIEK- 2123
Query: 528 VQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMN--LPGEV 585
V + A + HI + L E + N L +V
Sbjct: 2124 --------------------LRVRIEADEKKQLHIAEK-------LKERERENDSLKDKV 2156
Query: 586 TFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARA 645
L R+ E N + ++ D +TL + E++ L +
Sbjct: 2157 ENLE------RELQMSEENQELVIL---------DAENSKAEVETLKTQIEEMARSL-KV 2200
Query: 646 FTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQK---DVRKAEEELGELEAKLNENLRR 702
F +D +TL S + LT + + EL K + EE + E ++ E +
Sbjct: 2201 FELDLVTLR----SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256
Query: 703 NIERINNEIDQLMNQMQQIETQQRKFKASRDS----------ILSEMKMLKEKRQQSEKT 752
+E + N++ +L + + Q KA+ S + + ++ L+ + + EK
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKK 2316
Query: 753 FMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQ----LSLEDQK--------RVDAL 800
+ + L+ E ++ E+L+ EL +Q L E+ K +++ +
Sbjct: 2317 QLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
Query: 801 NDEIRQLQ-------QENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRET 853
+R L+ E L NE K + I+ +E +N + L + EQE +++E
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKE- 2434
Query: 854 EGGTVLTATTSELEAINKRV-------KDTMARSEDLDNSIDKTEAGIKELQKSMERWKN 906
+ T + ++L+ +N+RV + A+ ++L + ++ E +L + ++ KN
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLF 966
++N +E+E + L+KK+E + ++ K Q +QL
Sbjct: 2495 NYIVLQSSVNGLIQEVEDGKQK----LEKKDEEISRL------------KNQIQDQEQLV 2538
Query: 967 RKLEQCNTELKKYSHVNKKALDQFVNFSEQ----KEKLIKRQEELDRGYKSIMELMNVLE 1022
KL Q E + + N + + V ++ + K Q+ L+ S L N LE
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 1023 LRKYEAIQLTFK 1034
L K + + K
Sbjct: 2599 LTKMDKMSFVEK 2610
Score = 65.9 bits (159), Expect = 2e-10
Identities = 183/978 (18%), Positives = 398/978 (40%), Gaps = 99/978 (10%)
Query: 146 QMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINEL---LKYIEERLHT 202
++ A + + ++E R +E K+E+ L +E K ++ L LK I++ L+
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ 518
Query: 203 LEEEKEEL-AQYQKWDKMRRALEYTIYNQELNETRAKLD----ELSAKRETSGEKSRQLR 257
+ EE+ A+ + M R L+ I QE + T KL +L +R+ S + ++
Sbjct: 519 SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE 578
Query: 258 DAQQDARDKMEDIERQVREL-------KTKISAMKEEKEQLSAERQEQIKQRTKLELKAK 310
+ DK+ E++ + L K + +KEEK S + E K T++E + +
Sbjct: 579 HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 311 DLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQ 370
+LQ ++ + LK +Q + E+ + L E + + SV+ + +
Sbjct: 639 NLQSKI----NHLETCLKTQQIKSHEYNERVRTL-EMDRENLSVEIRNLHNVLDSKSVEV 693
Query: 371 ERTDL-YAKQGRGSQFTSKEERDKWIKKELKS--LDQAINDKKRQIAAIHKDLEDTEANK 427
E L Y + + ++F+ ++ + + LK+ L + D + ++ + ++ D +
Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCY 753
Query: 428 EKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKR 487
+ +Y L L A + + + ++ + Q ++ + EQ ++ ++R
Sbjct: 754 QDLHAEYESLRDLLKSKDASL--VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER 811
Query: 488 EDLEKKQQLLRAATGKAIL-NGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAF 546
+ + ++ AIL N +DS+ L+ +K +N +Q +V E E
Sbjct: 812 SECRLEAD--QSPKNSAILQNRVDSLEFSLES--QKQMNSDLQKQCEELVQIKGEIEENL 867
Query: 547 YTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDA 606
++ H E S +I + V L+ L+ ++ ND
Sbjct: 868 MKAEQM--------HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
Query: 607 IPM----ISKLRY-NPRFDKAFKHV--FGKTLICRSMEVSTQLA------RAFTMDCITL 653
+ I +L+ N + + K + +TL E+S+ ++ T + TL
Sbjct: 920 VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL 979
Query: 654 EGDQVS---------HRGALTGGYYDTRKSRLELQKDVRKAE--------EELGELEAKL 696
+ S + Y D R+ + D K E EE G L
Sbjct: 980 KEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDL 1039
Query: 697 NENLRRNIERINNEIDQLMNQMQQI-ETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMP 755
++ + E+ N++++ L+N+ + E ++ + + +++ E + K +E+
Sbjct: 1040 SQKYKAAQEK-NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQN 1098
Query: 756 KQRSLQSLEASLHA-MESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQL 814
L++++ +L + M + + K+E G ++L++++ + + E+ L QEN QL
Sbjct: 1099 LMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ--NKMQKEVNDLLQENEQL 1156
Query: 815 L------NERIKLEGIITRVETYLNENLRKRLD---QVEQELNELRETEGGTVLTATTSE 865
+ +E LE R E+ R + + Q++ E+ E+ L +
Sbjct: 1157 MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAM 1216
Query: 866 LEAINKRVKDTMARSEDLDNSI-----DKTEAGIKELQ-KSMERWKNMEKEHMDAINHDT 919
L +++++ E L + + D + ++++Q + + K+ E + +
Sbjct: 1217 LRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 920 KELEKMTNRQGMLLKKKEECMKKIRELGSLPQEA-FEKYQTLSLKQLFRKLEQCNTELKK 978
EL N L + M K+ EL + + EKY+ ++ +L +C T +K
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT--ELNDSRSECITATRK 1334
Query: 979 YSHVNKKALDQFVNFSEQKEKLI-KRQEELDRGY-------KSIMELMNVLELRKYEAIQ 1030
+ K L++ ++ L + E++ G + + L + E YE +
Sbjct: 1335 MAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLT 1394
Query: 1031 LTFKQVSKNFSEVFQKLV 1048
L+ K+V +F+E+ +K +
Sbjct: 1395 LSDKEVQMHFAELQEKFL 1412
Score = 62.8 bits (151), Expect = 2e-09
Identities = 188/950 (19%), Positives = 372/950 (39%), Gaps = 157/950 (16%)
Query: 141 QGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINE--------- 191
Q KINQ + ++LKL +++++ S L+K+ E E++N+
Sbjct: 541 QEKINQQENSLTLEKLKL-----AVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKES 595
Query: 192 --LLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETS 249
LL +E + EE KEE + W L T E ++K++ L +T
Sbjct: 596 KALLSALELKKKEYEELKEEKTLFSCWKSENEKL-LTQMESEKENLQSKINHLETCLKTQ 654
Query: 250 GEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKE-QLSAERQEQIKQRTKLELK 308
KS + + + E++ ++R L + + E E Q A + Q K +
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
Query: 309 AKDLQDELAGNSE---QRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARL 365
K++++ S+ Q + L + Q L +I +K + + ++ S+++ + A L
Sbjct: 715 QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Query: 366 AQATQERTDLYAKQGR-----------GSQFTSKEERDKW-------------IKKELKS 401
+ L A + G Q + ER + ++ + S
Sbjct: 775 VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834
Query: 402 LDQAINDKKRQIAAIHKDLEDTEANK---EKNLEQYNKLDQD-LNEVKARVEEL--DRKY 455
L+ ++ +K+ + + K E+ K E+NL + ++ Q + E R+ +L D
Sbjct: 835 LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894
Query: 456 YE---------VKNKKDELQSERNYLWREENAEQQALAAKR---EDLEKKQQLLRAATG- 502
++ ++NK+ ELQ + + E AE Q L ED K+ QLL
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKV-ETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
Query: 503 -KAILNGIDSINK--VLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLF 559
K ++ I S+NK + + + G + + + MN + +F ++ +
Sbjct: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER--EKSI 1011
Query: 560 YHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMI----SKLRY 615
+ D + IL++ E T L + A E N + + + L
Sbjct: 1012 SELSDQYKQEKLILLQ------RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065
Query: 616 NPRFD-KAFKHVFGKTLICRSMEVSTQLARAFTMD---CITLEGDQVSHRGALTGGYYDT 671
N + + + K F K E T+LA A + + LE Q + R +T ++
Sbjct: 1066 NRKNELEQLKEAFAK----EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
Query: 672 RKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQ-QIETQQRKFKA 730
+ L++++ +EE +++ ++N+ L+ N +QLM M+ + E Q + +
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN--------EQLMKVMKTKHECQNLESEP 1173
Query: 731 SRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLS 790
R+S+ KE+ + + Q L+ E SL + + L+A L +L
Sbjct: 1174 IRNSV-------KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRN---KELK 1223
Query: 791 L-EDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNE 849
L E +K + L E++ ++ + +ET NL+ D QE++
Sbjct: 1224 LQESEKEKECLQHELQTIRGD-----------------LET---SNLQ---DMQSQEISG 1260
Query: 850 LRETE---------GGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAG----IKE 896
L++ E G L+ + ++ + ++ TM + +L+ + +A + E
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 897 LQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEK 956
L S ++ + + E++ + + G+L + E + E G P E
Sbjct: 1321 LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPG-GEFGEQPNEQ--- 1376
Query: 957 YQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEE 1006
+SL L E Y H+ + ++F+E +EK + Q E
Sbjct: 1377 -HPVSLAPL--------DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417
Score = 62.8 bits (151), Expect = 2e-09
Identities = 112/493 (22%), Positives = 199/493 (40%), Gaps = 101/493 (20%)
Query: 60 QRLALLHEGTGPRV-ISAFVEIIFDNSDNRLPI--DKEEVSLRRVIGAKKDQYFLDKKMV 116
QR++ L E T + A +N + L + DK E + KK + L+ +
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL- 941
Query: 117 TKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESI 176
++ L E+ + I+ K + ++ L + GT KE +
Sbjct: 942 --KELQLLSETLSLEKKEMSSIISLNK----------REIEELTQENGTL-----KEINA 984
Query: 177 SLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETR 236
SL +E +K YI+ER E+ EL+ K +K+ I Q ET
Sbjct: 985 SLNQEKMNLIQKSESFANYIDER----EKSISELSDQYKQEKL-------ILLQRCEETG 1033
Query: 237 AKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELK-----------TKISAMK 285
++LS K + + EK+ +L + E+ + ++ +LK TK++ +
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 286 EEKEQLSAE--------RQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKI 337
E + L E R E + + +A L+ E+ E++ ++ KE LL++
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 338 EEKQKEL--------AETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKE 389
E+ K + E+EP NSVKE+E ER +Q K
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERE-----------SER----------NQCNFKP 1192
Query: 390 ERDKWIKKELKSLDQAINDKKRQIAAI--HKDLEDTEANKEKNLEQYNKLDQDLNEVKAR 447
+ D +K+ SLD + N + Q+ A+ +K+L+ E+ KEK L +L ++
Sbjct: 1193 QMDLEVKE--ISLD-SYNAQLVQLEAMLRNKELKLQESEKEKEC-----LQHELQTIRGD 1244
Query: 448 VEE---LDRKYYEVKNKKD-ELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGK 503
+E D + E+ KD E+ +E Y+ + L+ + D Q L+ K
Sbjct: 1245 LETSNLQDMQSQEISGLKDCEIDAEEKYI-----SGPHELSTSQNDNAHLQCSLQTTMNK 1299
Query: 504 AILNGIDSINKVL 516
LN ++ I ++L
Sbjct: 1300 --LNELEKICEIL 1310
Score = 60.5 bits (145), Expect = 1e-08
Identities = 194/992 (19%), Positives = 389/992 (39%), Gaps = 162/992 (16%)
Query: 246 RETSGEKSRQLRDAQQDARDKMEDIERQVRELK-----------TKISAMKEEKEQLSAE 294
+ETS E R L +D K+E + +++EL TKI A E ++ +
Sbjct: 1777 KETSNENLRLLH-VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGEL 1835
Query: 295 RQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN-S 353
++E KLE + D Q EL E + L + + +K ++++ + K N S
Sbjct: 1836 KKENSDLSEKLEYFSCDHQ-ELLQRVETSEGLNSDLEMHADK--SSREDIGDNVAKVNDS 1892
Query: 354 VKEK-----EERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
KE+ E R +A+ E LY E + ++ E L++ +
Sbjct: 1893 WKERFLDVENELSRIRSEKASIEHEALYL-----------EADLEVVQTEKLCLEKDNEN 1941
Query: 409 KKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSE 468
K++ I + ++L + + N+L +L+ + + LD+ ++K K EL+S
Sbjct: 1942 KQKVIVCLEEELSVVTSER-------NQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Query: 469 RNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHV 528
++ + ++++K +LL + + + + + K H + K Q +
Sbjct: 1995 QSEC-------LHCIQVAEAEVKEKTELL-----QTLSSDVSELLKDKTHLQEK--LQSL 2040
Query: 529 QNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKIL-MEFNKMNLPG--EV 585
+ + + E E ++ L + +S+ + ++ ++ K+N+ E
Sbjct: 2041 EKDSQALSLTKCELENQI---AQLNKEKELL--VKESESLQARLSESDYEKLNVSKALEA 2095
Query: 586 TFLPLNKLDVR-DTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLAR 644
+ + +R + E + I KLR D+ + + L R E + +
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 645 AFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNI 704
++ ++ L D S+ E++ + EE L+ ++
Sbjct: 2156 VENLERELQMSEENQELVIL-----DAENSKAEVETLKTQIEEMARSLKV-----FELDL 2205
Query: 705 ERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLE 764
+ +E + L Q+Q+ + Q + D +LS K L E+++Q+E K+ S ++E
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSEL----DKLLSSFKSLLEEKEQAE--IQIKEESKTAVE 2259
Query: 765 ASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGI 824
+ ++ E++ A G DQ+ + A + +E QL N KL
Sbjct: 2260 MLQNQLKELNEAVAALCG----------DQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
Query: 825 ITRVE-------TYLNEN------LRKRLDQVEQELNELRETEGGTVLTATTS--ELEAI 869
+ E L E+ L+ R++ +E+EL R + L A S E+E +
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 870 NKRVK--------------DTMARSEDLDNSIDKTEAGIKELQKSMERWKN--------- 906
+++ + E+L N + K + I EL+ ++N
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429
Query: 907 --MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQ 964
M+++ A+ +L+++ R L +E C K + L S E E L Q
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS-QVECLE----LEKAQ 2484
Query: 965 LFRKLEQC-NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMN-VLE 1022
L + L++ N + S VN L Q V + K+KL K+ EE+ R I + V +
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVN--GLIQEV--EDGKQKLEKKDEEISRLKNQIQDQEQLVSK 2540
Query: 1023 LRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSG 1082
L + E +K+ + + +L K ++ K + QD E S +
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQ--KIQVLQSK----NASLQDTLEVLQSSYKNLE 2594
Query: 1083 SQSSVPSVDQFTGVGIRVSFTGKQGEMR-----------EMQQLSGGQKSLVALALIFAI 1131
++ + +D+ + V T K+ E++ E+Q+ G+K+ +A L +
Sbjct: 2595 NELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
Query: 1132 QKCDPAPFYLFD------EIDQALDAQHRKAV 1157
++ + L + E+ ++LD H+ V
Sbjct: 2655 EEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686
Score = 55.8 bits (133), Expect = 2e-07
Identities = 152/806 (18%), Positives = 296/806 (36%), Gaps = 144/806 (17%)
Query: 230 QELNETRAKLDELSAKRETSGEKSRQLRDAQQDARD-KMEDIERQVRELKTKISAMKEEK 288
Q++ E +LD+L +K +Q R Q D+ + ++ +++V KT+ + +K E
Sbjct: 18 QKIQELEGQLDKL--------KKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 289 EQLS--AERQEQIKQRTKLELKAKDLQ-----DELAGNSEQRKRLLKERQKLLEKIEEKQ 341
++L E E+ KQ+ EL+ K+ Q +L +Q ++L +E ++ ++E Q
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 342 KELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKS 401
+ + N ++ L + Y + ++ + E K ++ E+K+
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKY--EDLKEKYNKEVEERKRLEAEVKA 187
Query: 402 LD-QAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARV---EELDRKYY- 456
L + + Q H+D+ +A+ Q K L+ R + Y+
Sbjct: 188 LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247
Query: 457 ---EVKNKKDELQ-------------SERNYLWREENAEQQALAAKREDLEKKQQLLRAA 500
EV + LQ S +L + A+ Q L K +LE LR
Sbjct: 248 GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE-----LRLQ 302
Query: 501 TGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFY 560
+ + G +NK Q +Q + E E C + Y
Sbjct: 303 GHEKEMKG--QVNKF----------QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 561 HIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFD 620
D+ STK K L KL D + N S + +
Sbjct: 351 -----DQASTKYTALEQK-----------LKKL-TEDLSCQRQNAESARCSLEQKIKEKE 393
Query: 621 KAFKHVFGKTLICRSMEVSTQLARAFTMD--CITLEGDQVSHRGALTGGYYDTRKSRLEL 678
K F+ E+S Q T+D CI + + LT + L
Sbjct: 394 KEFQE-----------ELSRQQRSFQTLDQECIQM-------KARLTQELQQAKNMHNVL 435
Query: 679 QKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSE 738
Q ++ K +LE N+E ++ + Q + ++ + + S + + E
Sbjct: 436 QAELDKLTSVKQQLE--------NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 739 MKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVD 798
+LK +Q + + L++++ L+ ++ E +KA ++ +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA------------KNTSQET 535
Query: 799 ALNDEIRQLQQENRQLLNERIKLE-GIITRVETYLNENLRKRLDQVEQELNELRETEGGT 857
L D ++ Q+ L E++KL + + + L+KR +EQ ++L +TE +
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKES 595
Query: 858 VLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINH 917
A S LE K ++ +KE + WK+ ++ + +
Sbjct: 596 --KALLSALELKKKEYEE------------------LKEEKTLFSCWKSENEKLLTQMES 635
Query: 918 DTKELEKMTNRQGMLLK----KKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCN 973
+ + L+ N LK K E +++R L E + ++ ++ L L+ +
Sbjct: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTL-----EMDRENLSVEIRNLHNVLDSKS 690
Query: 974 TELKKYSHVNKKALDQFVNFSEQKEK 999
E++ + L Q FS+QK +
Sbjct: 691 VEVET-QKLAYMELQQKAEFSDQKHQ 715
Score = 50.1 bits (118), Expect = 1e-05
Identities = 48/203 (23%), Positives = 90/203 (44%), Gaps = 8/203 (3%)
Query: 166 RVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEE---KEELAQYQKWDKMRRA 222
+V +E E + L + + + + + K E + T E+ KEE QK +
Sbjct: 2691 KVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLK 2750
Query: 223 LEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKIS 282
N L T L+EL + + + QL+ + A+ KM+ + + ++L+ +
Sbjct: 2751 SSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKE 2810
Query: 283 AMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQK 342
+++E QL A +++Q K T ++ K DEL ++ K L+E+ K ++ +K
Sbjct: 2811 ILQKELSQLQAAQEKQ-KTGTVMDTKV----DELTTEIKELKETLEEKTKEADEYLDKYC 2865
Query: 343 ELAETEPKFNSVKEKEERGIARL 365
L + K KE E +A L
Sbjct: 2866 SLLISHEKLEKAKEMLETQVAHL 2888
Score = 49.7 bits (117), Expect = 2e-05
Identities = 65/301 (21%), Positives = 134/301 (44%), Gaps = 23/301 (7%)
Query: 111 LDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGK------INQMATAPDSQRLKLLREVAG 164
L K + D + +L+S+ + N + K K +N+M TA +++ + + E+A
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM-TAKETELQREMHEMAQ 2630
Query: 165 TRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALE 224
E +EE G+ + + E +K +++L L E EL + + +
Sbjct: 2631 KTA--ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688
Query: 225 YTIYNQELNETRAKLDELSAKRETSG-EKSRQLRDAQQDARDKMEDIERQVRELKTKISA 283
+E+ E + +L E K + + ++Q Q R+K+ E + K +I
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748
Query: 284 MKEEKEQLSAERQ------EQIKQRTKLELK-AKDLQDELAGNSEQRKRLLKERQKLLEK 336
+K KE+L+ + E++K+ LK L+ E + K L+K ++L E+
Sbjct: 2749 LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE 2808
Query: 337 IEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIK 396
E QKEL++ + + +EK++ G + + T++ K+ + + +E D+++
Sbjct: 2809 KEILQKELSQLQ----AAQEKQKTGTVMDTKVDELTTEI--KELKETLEEKTKEADEYLD 2862
Query: 397 K 397
K
Sbjct: 2863 K 2863
Score = 35.8 bits (81), Expect = 0.26
Identities = 49/240 (20%), Positives = 100/240 (41%), Gaps = 21/240 (8%)
Query: 172 KEESISLMKET----EGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTI 227
KEE +S K + +E++N LK + L L++ K + +Y +++++ E
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV--NQLKKENERAQ 2792
Query: 228 YNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARD------KMEDIERQVRELKTKI 281
+L K +L ++E ++ QL+ AQ+ + K++++ +++ELK +
Sbjct: 2793 GKMKLLIKSCK--QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETL 2850
Query: 282 SAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQ 341
+E ++ + + KLE + L+ ++A Q+ + LL +
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGP 2910
Query: 342 KELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKS 401
+ SV EK A ++R+ + GRG + E K KK + S
Sbjct: 2911 SPIP-------SVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVMS 2963
Score = 35.0 bits (79), Expect = 0.44
Identities = 76/407 (18%), Positives = 161/407 (39%), Gaps = 62/407 (15%)
Query: 689 LGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQ 748
L E + L + I+ + ++D+L E QQR+F+ DS+ + ++ K+K +
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKK-----EKQQRQFQL--DSLEAALQKQKQKVEN 57
Query: 749 SEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLED------QKRVDALND 802
+ +R Q L ++E T++ + EL SQ++ ++ +K+++ L
Sbjct: 58 EKTEGTNLKRENQRLMEICESLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQ 116
Query: 803 EIRQLQQENRQ----------LLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE 852
E+++ + E + LN + I T T + + ++++ N +E
Sbjct: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYN--KE 174
Query: 853 TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHM 912
E L A L+A K+ T+ ++ I + +A E+ + +
Sbjct: 175 VEERKRLEAEVKALQA--KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
Query: 913 D--------AINHDTKELEKMTNRQGMLLKKK-----------------------EECMK 941
+ ++ + E E +R + + K+ +E
Sbjct: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRN 292
Query: 942 KIRELGSLPQ--EAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEK 999
KI EL Q E K Q ++L +LE+ EL + V K D+ V + Q ++
Sbjct: 293 KINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ 352
Query: 1000 LIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQK 1046
+ L++ K + E ++ + + E+ + + +Q K + FQ+
Sbjct: 353 ASTKYTALEQKLKKLTEDLS-CQRQNAESARCSLEQKIKEKEKEFQE 398
Score = 34.7 bits (78), Expect = 0.57
Identities = 23/98 (23%), Positives = 53/98 (54%)
Query: 263 ARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQ 322
A K++++E Q+ +LK + + + + L A Q+Q ++ + + +L+ E E
Sbjct: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 323 RKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER 360
+ L K +QK+ +++ K+ ++ E + NS K++ E+
Sbjct: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK 113
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 107 bits (267), Expect = 7e-23
Identities = 181/917 (19%), Positives = 380/917 (41%), Gaps = 61/917 (6%)
Query: 182 TEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDE 241
TE K + ++E + +EE + L +EK+ L + + +E N L + AKL++
Sbjct: 975 TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG-LIKINAKLEQ 1033
Query: 242 LSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQ 301
+ E S E+ ++LR D+ER R+L+ + +E L ++Q+ ++
Sbjct: 1034 QTDDLEGSLEQEKKLR----------ADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 302 RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERG 361
K E + LQ ++ + K+ ++L +IEE ++E+ E E + EK+
Sbjct: 1084 LKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI-EAEHTLRAKIEKQRSD 1142
Query: 362 IARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421
+AR + ER + A +Q ++R+ +K + L++A + A + K
Sbjct: 1143 LARELEEISERLE-EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA 1201
Query: 422 DTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE-ENAEQ 480
D+ A + ++ ++ Q L + K+ EL + ++ + + L ++ + R E
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKS---ELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 481 QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHF--RRKGINQHVQNGYHGIVMN 538
Q K +D ++ Q + KA L + N L H ++ + + +
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQ---TQNGELSHRVEEKESLISQLTKSKQALTQ- 1314
Query: 539 NFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTF---LPLNKLDV 595
+ E E T H + S +L E + + L +V
Sbjct: 1315 --QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 596 RDTAYPETNDAIPMISKL-----RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDC 650
DAI +L + R +A ++ C S+E + Q + D
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 651 ITLEGDQVSHRGALTGGYYDTRKSRLE--LQKDVRKAEEELGELEA--KLNENLRRNIER 706
+ + SH T D ++ + L + +K +E ELEA K + +L + +
Sbjct: 1433 --MRDLERSHTACAT---LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFK 1487
Query: 707 INNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEAS 766
+ N +++++Q++ + + + + + ++ + Q++EKT ++ L+ +
Sbjct: 1488 MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 767 LHAMESTRESLKAE-LGTDL-LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGI 824
L +E + E +++ L L LSQ+ E ++V ++EI QL++ +++ L+ +
Sbjct: 1548 LEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEA---LQSV 1604
Query: 825 ITRVETYLNENLRKRLDQVEQELNELRETEGGT--VLTATTSELEAINKRVKDTMARSED 882
+ N+ LR + ++E +LNE+ G + + T L + ++KD+
Sbjct: 1605 LDAEIRSRNDALRLK-KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH--- 1660
Query: 883 LDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKK 942
LD+++ E +KE +ER + E ++ + ++ E+ L + ++
Sbjct: 1661 LDDALRSNE-DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 943 IRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIK 1002
+ + +K + + Q ++E E + KKA+ +E+ +K
Sbjct: 1720 LHSQNTSLINTKKKLEA-DIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDV 1062
L+R K++ + + L+ R EA QL K K QKL + + + DV
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ----IQKL--ENRVRELENELDV 1832
Query: 1063 EGSQSQDEGEGSGESER 1079
E + + +G+ + ER
Sbjct: 1833 EQKRGAEALKGAHKYER 1849
Score = 101 bits (252), Expect = 4e-21
Identities = 182/997 (18%), Positives = 402/997 (40%), Gaps = 154/997 (15%)
Query: 170 ERKEESISLMKETEGKREKI---NELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYT 226
E ++E ++ ++ E +E++ K +EE++ +L +EK +L Q Q + ++
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDL-QLQVQSETENLMDAE 906
Query: 227 IYNQELNETR----AKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKIS 282
+ L +++ AK+ EL+ + E E + +L +++ DK ++R + +L+ ++
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 283 AMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQK 342
+++EK E K K+L +E+ E +L KE++ L E ++
Sbjct: 967 KVEKEKH--------------ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD 1012
Query: 343 ELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK-WIKKELKS 401
+L E K N + I A+ Q+ DL + + + ER K ++ +LK
Sbjct: 1013 DLQVEEDKVNGL-------IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKM 1065
Query: 402 LDQAINDKKRQIAAIH-----KDLEDTEANKEKNLEQYNKL--DQDLNEVKARVEELDRK 454
++I D + I K+ E ++ + + EQ + L + + E++AR+EEL+ +
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEE 1125
Query: 455 YYEVKNKKDELQSERNYLWRE------------------------ENAEQQALAAKREDL 490
+ +++ +R+ L RE AE Q + E+
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 491 EKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVM------NNFECEP 544
+ + A K + + + + +D+ +R + Q ++ + M +N E
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQR--VKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 545 AFYTCVEVTAG--NRLFYHIVDSDEVSTKILMEFNKMNL-----PGEVTFLPLNKLDVRD 597
+ +E T F I DE T+++ + N GE++ ++++ ++
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS----HRVEEKE 1299
Query: 598 TAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQ 657
+ + SK + ++ + + +T +M + Q +R DC L
Sbjct: 1300 SLISQLTK-----SKQALTQQLEELKRQMEEETKAKNAMAHALQSSR---HDCDLLREQ- 1350
Query: 658 VSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQ 717
Y + ++++ ELQ+ + KA E+ + K + + E + +L +
Sbjct: 1351 ----------YEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 718 MQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESL 777
+Q+ E + ++ S+ L++ +Q+ + R L+ + ++ + +
Sbjct: 1401 LQEAE-------ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF 1453
Query: 778 KAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLR 837
L E ++++D E+ Q+E+R L E K+ V L E LR
Sbjct: 1454 DKVLA---------EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL-ETLR 1503
Query: 838 KRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIK 895
+ +++E+++L E E G L + + + D E+++ S++ E+ I
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563
Query: 896 ELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFE 955
+Q + + K+ + + + ++L++ + R L+ L E
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQ------------SVLDAEIRS 1611
Query: 956 KYQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKS- 1013
+ L LK +K+E E++ + H N++ + + + +L Q LD +S
Sbjct: 1612 RNDALRLK---KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN 1668
Query: 1014 --------IMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVM-------- 1057
I+E N L L + E +++ +Q + Q+L+ ++
Sbjct: 1669 EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLI 1728
Query: 1058 ---KKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVD 1091
KK + + +Q Q E E S + R + ++ D
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765
Score = 99.4 bits (246), Expect = 2e-20
Identities = 200/996 (20%), Positives = 404/996 (40%), Gaps = 141/996 (14%)
Query: 113 KKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERK 172
+K T+N V NL E N + K+ K Q A L++ + + K
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 173 ------------EESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMR 220
E+ L + E + K+ LK +E + LE +K+++ + K +
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 221 RA-LEYTI---------YNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDI 270
+ L+ I + +++ E +A+++EL + E ++ + D ++E+I
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 271 ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELK--------AKDLQDELAGNSEQ 322
++ E SA E ++ AE Q+ + + L+ K D +A EQ
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 323 RKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRG 382
L + +QKL ++ E + E+ + ++ K + I R + +++
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEAL-SKSKSNIERTCRTVEDQF--------- 1260
Query: 383 SQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNK----LD 438
S+ +K+E+ + +L N +K ++ + +L KE + Q K L
Sbjct: 1261 SEIKAKDEQQTQLIHDL-------NMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 439 QDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLR 498
Q L E+K ++EE + + + + + + L + EQ+A A + L K +
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 499 AATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRL 558
K + I ++ + +K + Q +Q N +C
Sbjct: 1374 QWRTKYETDAIQRTEELEE--AKKKLAQRLQEAEENTETANSKCAS-------------- 1417
Query: 559 FYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPR 618
+E K L GEV L +RD T A + K + N
Sbjct: 1418 ---------------LEKTKQRLQGEVEDL------MRDLERSHT--ACATLDKKQRN-- 1452
Query: 619 FDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE- 677
FDK K ++ S A + +L + R A Y+ +LE
Sbjct: 1453 FDKVLAEWKQK------LDESQAELEAAQKESRSLSTELFKMRNA-----YEEVVDQLET 1501
Query: 678 LQKDVRKAEEELGELEAKLNENLR--RNIERINNEIDQLMNQMQ-QIETQQRKFKASRDS 734
L+++ + +EE+ +L ++ E + + E+ ++Q + +Q +E + +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 735 ILSEMKMLKEKRQQSEKTFMPKQRSLQSLEA-SLHAMESTRESLKAELGTDLLSQLSLED 793
IL L + + + ++ + K ++ L+ S A E+ + L AE+ + +L
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRS---RNDALRL 1618
Query: 794 QKRVDA-LNDEIRQLQQENRQLLNERIKL---EGIITRVETYL------NENLRKRLDQV 843
+K+++ LN+ QL NRQ+ + L +G + + +L NE+L+++L V
Sbjct: 1619 KKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIV 1678
Query: 844 E-------QELNELRETEGGTVLTATTSELEAI--NKRVKDTMARSEDLDNSIDKTEAGI 894
E +EL E++ T T SE E + + RV+ +++ L N+ K EA I
Sbjct: 1679 ERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADI 1738
Query: 895 ----KELQKSMERWKNMEKEHMDAINHD---TKELEKMTNRQGMLLKKKEECMKKIRELG 947
E++ S++ +N E++ AI +EL+K + L + K+ + +++L
Sbjct: 1739 AQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798
Query: 948 SLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQE-E 1006
EA E+ K+ +KLE EL+ V +K + + + + E+ +K +
Sbjct: 1799 HRLDEA-EQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQ 1857
Query: 1007 LDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ +K+I+ L ++++ K +A ++K+ ++ E
Sbjct: 1858 AEEDHKNILRLQDLVD--KLQAKVKSYKRQAEEAEE 1891
Score = 90.1 bits (222), Expect = 1e-17
Identities = 164/896 (18%), Positives = 358/896 (39%), Gaps = 128/896 (14%)
Query: 140 KQGKINQMATAPDSQR---LKLLREVAGTRVYDERKEESI----SLMKETEGKREKINEL 192
K+ +++Q+ D ++ L+ +++ + E EE I +L + E +R +
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 193 LKYIEERLHT--------LEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSA 244
L+ I ERL +E K+ A++QK MRR LE E + + +
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQK---MRRDLEEATLQHEATAATLRKKQADS 1203
Query: 245 KRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTK 304
E GE+ L+ +Q + +++ ++ ++ + I A+ + K + ER + +
Sbjct: 1204 VAEL-GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI--ERTCRTVEDQF 1260
Query: 305 LELKAKDLQDE--LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGI 362
E+KAKD Q + + Q+ RL + +L ++EEK+ +++ ++ ++ E
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 363 ARLAQATQERTDL-YAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421
++ + T+ + + +A Q E+ + ++ L +A++ ++A E
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 422 DTEANKEKNLEQYNK-LDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ 480
+ + LE+ K L Q L E + E + K ++ K LQ E L R+
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 481 QA--------------LAAKREDLEKKQQLLRAATGKA---------ILNGIDSINKVLD 517
A LA ++ L++ Q L AA ++ + N + + L+
Sbjct: 1441 TACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLE 1500
Query: 518 HFRR--KGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILME 575
RR K + + + + I + A T +V+ ++ ++ +E
Sbjct: 1501 TLRRENKNLQEEISDLTEQIAETGKNLQEAEKT-----------KKLVEQEKSDLQVALE 1549
Query: 576 FNKMNLPGEVTFLPLNKLDVR------DTAYPETNDAIPMISKLRYNPRFDKAFKHVFGK 629
+ +L E + + +L++ D E ++ I + R + R +A + V
Sbjct: 1550 EVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLK--RNSQRAAEALQSVLDA 1607
Query: 630 TLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEEL 689
+ RS + +L + D +E Q+ H + + E QK +R + +L
Sbjct: 1608 EI--RSRNDALRLKKKMEGDLNEME-IQLGH----------SNRQMAETQKHLRTVQGQL 1654
Query: 690 GELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQS 749
+ + L++ LR N + L Q+ +E + + + ++ + R+ S
Sbjct: 1655 KDSQLHLDDALRSN--------EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 750 EKTFMPKQRSLQSLEASLHAMESTRESLKAELGT------DLLSQLSLEDQKRVDALND- 802
E+ + +Q L + ++ +T++ L+A++ + + + ++K A+ D
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766
Query: 803 -----EIRQLQQENRQLLNERIKLEGIITRVETYLNE--------------NLRKRLDQV 843
E+++ Q + L + LE + ++ L+E L R+ ++
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826
Query: 844 EQELNELRETEGGTVLTATTSELEAINKRVKDTMARSED-------LDNSIDKTEAGIKE 896
E EL ++ + G L ++VK+ ++E+ L + +DK +A +K
Sbjct: 1827 ENEL-DVEQKRGAEALKGA----HKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKS 1881
Query: 897 LQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQE 952
++ E + + ELE+ R + + + K R++GS E
Sbjct: 1882 YKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 12/195 (6%)
Query: 332 KLLEKIEEKQKELAETEPKFNSVKEKEERGIAR-------LAQATQERTDLYAK-QGRGS 383
K L K E +KE+A + F KE+ R AR + QE+ DL + Q
Sbjct: 841 KPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE 900
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLE-QYNKLDQDLN 442
EER + + K L+ + + ++ +++ K++NLE + + L +D++
Sbjct: 901 NLMDAEERCEGLIKSKILLEAKVKELTERLEE-EEEMNSELVAKKRNLEDKCSSLKRDID 959
Query: 443 EVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATG 502
+++ + +++++ + +NK L E L EEN + K +Q L
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTAL--EENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 503 KAILNGIDSINKVLD 517
+ +NG+ IN L+
Sbjct: 1018 EDKVNGLIKINAKLE 1032
Score = 33.1 bits (74), Expect = 1.7
Identities = 67/342 (19%), Positives = 129/342 (37%), Gaps = 42/342 (12%)
Query: 44 AIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIG 103
A+Q VL E RL EG + EI +S+ ++ + + LR V G
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEM-----EIQLGHSNRQMA--ETQKHLRTVQG 1652
Query: 104 AKKD-QYFLDKKMVTKNDVMN-----------LLESAGFSRSNPYYIVKQGKINQMATAP 151
KD Q LD + + D+ LLE + + ++++
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLD 1712
Query: 152 DSQRLKLLREVAGTRVYDERKEES------ISLMKETEGKREKINELLKYIEERLHTLEE 205
S R++LL + + ++K E+ + + R + K I + EE
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEE 1772
Query: 206 EKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARD 265
K+E ++M++ LE T+ + + +LDE G+K Q + + +
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTV-----KDLQHRLDEAEQLALKGGKKQIQKLENRVRELE 1827
Query: 266 KMEDIERQ----------VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDE 315
D+E++ E K K + E++ + R + + KL+ K K + +
Sbjct: 1828 NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVD--KLQAKVKSYKRQ 1885
Query: 316 LAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEK 357
EQ L +++ ++EE + E + N ++ K
Sbjct: 1886 AEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 107 bits (266), Expect = 9e-23
Identities = 214/1014 (21%), Positives = 417/1014 (41%), Gaps = 167/1014 (16%)
Query: 172 KEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQE 231
KE +S+ + + +++IN+L ++ER L+E + + + K E
Sbjct: 741 KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG--------E 792
Query: 232 LNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQL 291
L + AKLD + + + E+++ + + K+ D+E + L +++ ++ +K+ +
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 292 SAE-----------RQEQIKQRTKLELKAKDLQDELA-----GNSEQR--KRLLKERQKL 333
E Q+ KQ +++E K K L GN EQ K++L E++ +
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 334 LEKIEEKQKELAETEPKFNSVKE-------KEERGIARLAQATQERTDLYAKQGRGSQFT 386
+ ++ E QK+ E + S KE +E + + E+ AK+ + +
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 387 SKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKA 446
+++ +KKEL++ ++ K++Q A K LE +AN + ++L+ + E
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 447 RVEELDRK----YYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATG 502
+ E+ R+ + KK Q+E +E E Q ++E E KQ++L
Sbjct: 1031 SLTEVHRRELNDVISIWEKKLNQQAEE----LQEIHEIQLQEKEQEVAELKQKILLFGCE 1086
Query: 503 KAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHI 562
K + +NK + + +G+ Q +N + E +
Sbjct: 1087 K------EEMNKEITWLKEEGVKQDT-------TLNELQ---------EQLKQKSAHVNS 1124
Query: 563 VDSDEVSTKILMEFNKMNLPG---EVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRF 619
+ DE K +E +++L E TFL ++++ A + + SKL+
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE 1184
Query: 620 DKAFKHVF---GKTLICRSME---VSTQLARAFTMDCITLEGDQVSHRGAL---TGGYYD 670
++ K K+L +S+E +S +LA + C E + L + +
Sbjct: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244
Query: 671 TRKSRLE-LQKDVRKAEEEL-------GELEAKLNENLRRNIERINNEIDQLMNQMQQIE 722
SR+ Q K +E L ELEA+L + L +N Q +Q+++ E
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ-LTEEQNTLNISFQQATHQLEEKE 1303
Query: 723 TQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASL----HAMESTRESLK 778
Q + KA +S+++E + L+++ ++ K+ + L+ L +A+ +E LK
Sbjct: 1304 NQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK 1363
Query: 779 -------------AELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLE--- 822
+L L + +SL +++ A++ +Q +E +LL++ L
Sbjct: 1364 EKKVEISSLSKQLTDLNVQLQNSISLSEKEA--AISSLRKQYDEEKCELLDQVQDLSFKV 1421
Query: 823 --------GIITRVETYLN----------------ENLRKRLDQVEQELNELRETEGGTV 858
+ +V+ + N +N K L Q++ EL E
Sbjct: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL-QIQLELKSKEAYEKDEQ 1480
Query: 859 LTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIK-ELQKSMERWKNMEKEHMDAINH 917
+ EL+ NKR ED + ++K E+ ++ EL+ R +E D I
Sbjct: 1481 INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE----DHITQ 1536
Query: 918 DTKELEKMTN-----RQGMLLKKKE--ECMKKIRELG----SLPQEAFEKYQTLSLKQLF 966
T E+E + Q ++ KE + ++ +ELG + +EA EK TL Q++
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE-NQVY 1595
Query: 967 RKLEQCNTELKKYSHVN---------KKALDQFVNFSEQKEKLIKRQEELDRGYKSI-ME 1016
+ T+ K+ HVN KAL+ + SE KL + + + ++ +I +
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLE-SESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 1017 LMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVM--KKGDVEGSQSQ 1068
L++ +E E + K + SE+ KL + ++ K VE SQS+
Sbjct: 1655 LLSQME----EKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Score = 100 bits (250), Expect = 6e-21
Identities = 204/1035 (19%), Positives = 419/1035 (40%), Gaps = 155/1035 (14%)
Query: 59 EQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTK 118
E+R++L E + RV V+++ +S+ ++ + L A+K+Q L KK+ T+
Sbjct: 450 EERISLQQELS--RVKQEVVDVMKKSSEEQIA---KLQKLHEKELARKEQE-LTKKLQTR 503
Query: 119 NDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISL 178
+S Y+ KI+Q +S L+ L E+ + E + + L
Sbjct: 504 EREFQEQMKVALEKSQSEYL----KISQEKEQQESLALEEL-ELQKKAILTESENKLRDL 558
Query: 179 MKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTI----YNQELNE 234
+E E R +I EL +E+ L + + ++LA + + +K + E T+ + EL
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618
Query: 235 TR--------AKLDELSAKRETSGEKSRQLRDAQQDA--RDKMEDIERQVRELKTK---- 280
+ KL L + +T EK R+ + +++ +DK + + E+ K
Sbjct: 619 LKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK 678
Query: 281 ISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQD-------ELAGNSEQRKR-------- 325
+ + E E LS+E E +K R KLE + L+D EL +++K
Sbjct: 679 LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS 738
Query: 326 LLKERQKLLEKIE---------------EKQKELAETEPKFNSVKEKEERGIARLAQATQ 370
++KE + +++ E E+ K L E + +++ +R L QA+
Sbjct: 739 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS- 797
Query: 371 ERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKN 430
+ D++ S ++ E+ K +++L L Q + D + + + K + + EA K+
Sbjct: 798 AKLDVFQ-----SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK-- 850
Query: 431 LEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL 490
+ +LD +V+ +++L+++ E++ K L + N EQ+ K+ +
Sbjct: 851 -DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE--QTKQILV 907
Query: 491 EKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCV 550
EK+ +L+ G+ I + K + H+ N + N E +
Sbjct: 908 EKENMILQMREGQK-----KEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Query: 551 EVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMI 610
L ++D E K +E + L + L++ +DA +
Sbjct: 963 AKEMQETLKKKLLD-QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA---V 1018
Query: 611 SKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYD 670
S+L N + +E T++ R D I++ +++ +
Sbjct: 1019 SRLETNQK---------------EQIESLTEVHRRELNDVISIWEKKLNQQAE------- 1056
Query: 671 TRKSRLELQK----DVRKAEEELGELEAKL------NENLRRNIERINNEIDQLMNQMQQ 720
ELQ+ +++ E+E+ EL+ K+ E + + I + E + + +
Sbjct: 1057 ------ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 721 IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE 780
++ Q ++ A +S+ + LK L+ LE L+ +S +E+ +
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLK--------------AHLEKLEVDLN--KSLKENTFLQ 1154
Query: 781 LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVE---TYLNENLR 837
L L+ ED+++V L +++ +E + L + K + L+E L
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 838 KRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKEL 897
+LD ++ L E + ++ ++S+ AI R+ R+ + ++ + EL
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 898 QKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKY 957
+ + + + + T +LE+ N+ + K + + E +L +E +
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQ---IKSMKADIESLVTEKEALQKEGGNQQ 1331
Query: 958 QTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSI--- 1014
Q S K E C T+LKK N A+ + KE+L +++ E+ K +
Sbjct: 1332 QAASEK------ESCITQLKKELSENINAV------TLMKEELKEKKVEISSLSKQLTDL 1379
Query: 1015 -MELMNVLELRKYEA 1028
++L N + L + EA
Sbjct: 1380 NVQLQNSISLSEKEA 1394
Score = 100 bits (248), Expect = 1e-20
Identities = 198/967 (20%), Positives = 425/967 (43%), Gaps = 98/967 (10%)
Query: 141 QGKINQMATAPDS-QRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEER 199
+GK +++ TA QR K +++ G + + +++S+ + E + + + K+++E
Sbjct: 154 RGKYSELVTAYQMLQREK--KKLQG--ILSQSQDKSLRRIAELREELQMDQQAKKHLQEE 209
Query: 200 LHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAK-LDELSAKRETSGEKSRQLRD 258
EEK++ + L+ + N +N K L +L + E ++ D
Sbjct: 210 FDASLEEKDQYISVLQTQVS--LLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESD 267
Query: 259 AQQDARD-----KMEDIERQVRELKTKISAMKE----EKEQ---LSAER---QEQIKQRT 303
+ D +E ++++V+ + + KE KEQ L++E+ QEQ+ +R
Sbjct: 268 GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL 327
Query: 304 KLELKAKDLQDELAGNSEQRKRL--LKERQKLLEKIEE-KQKELAETEPKFNSVKEKEER 360
+ K KDL +E+ K + L++ + L+E++E+ K +AET+ + + E +E
Sbjct: 328 QELEKIKDLH-----MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE 382
Query: 361 GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHK-- 418
IA+L ++ T +G + +E+++K + + L++A++ ++ A K
Sbjct: 383 EIAQLRSRIKQMTT------QGEEL--REQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
Query: 419 -DLEDTEANKEKNLEQYN-KLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREE 476
++++ EK E+ L Q+L+ VK V ++ +K E + K + E+ +E+
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 477 NAEQQALAAKREDLEKKQQLLRAATGKAIL-----NGIDSINKVLDHFRRKGINQHVQNG 531
++ +RE E+ + L + + + +S+ ++K I +N
Sbjct: 495 ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
Query: 532 YHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLN 591
+ E +E + L + S +++ + E NK N E+T + +
Sbjct: 555 LRDL-QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK--EITVM-VE 610
Query: 592 KLDVRDTAYPETNDAI----PMISKLRYNPRFDKAF-KHVFGKTLICRSMEVSTQLARAF 646
K + DA+ + K +Y +K K K + + E+ Q A
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-AHIE 669
Query: 647 TMDCITLEGDQVSHRG--ALTGGYYDTRKSRLELQKDVRKAEEELG----ELEAKLNENL 700
M+ TLE V +L+ + K+R +L++++ +++ ELEAK++E
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
Query: 701 RRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSL 760
+ +++++ I + +Q+ E KA +D I +LKE+ +K Q +
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTE------KALKDQINQLELLLKER----DKHLKEHQAHV 779
Query: 761 QSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIK 820
++LEA + E + A+L D+ ++ A +++ QLQQ+ L ERI
Sbjct: 780 ENLEADIKRSEGELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL 837
Query: 821 LEGIITRVETYLNE----------NLRKRLDQVEQELNELRETEGGTVLTATTSELEAIN 870
L + VE + ++ + Q+E++ +E+ E + ++ S+LE N
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM-EQKVKSLTQVYESKLEDGN 896
Query: 871 KRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQG 930
K + T + +N I + G K+ + + + + +++ + +N + + K ++
Sbjct: 897 KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 956
Query: 931 MLLKKKEECMKKIRELGSLPQEA-FEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQ 989
+K+K + M++ + L QEA +K + +L +K +Q N ++ + + N +
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
Query: 990 FVNFSE--QKEKLIKRQEELDRGYKSIMEL------MNVLELRKYEAIQLTFKQVSKNFS 1041
V+ E QKE++ E R ++ + EL++ IQL K+ + +
Sbjct: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKE--QEVA 1074
Query: 1042 EVFQKLV 1048
E+ QK++
Sbjct: 1075 ELKQKIL 1081
Score = 92.8 bits (229), Expect = 2e-18
Identities = 196/1069 (18%), Positives = 424/1069 (39%), Gaps = 157/1069 (14%)
Query: 91 IDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLL----ESAGFSRSNPYYIVKQGKINQ 146
++KE + L+ G KK+ L +K+ K D +++L E+ ++ VKQ
Sbjct: 907 VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEM 966
Query: 147 MATAPDS---QRLKLLREVAGTRVYDERKEESISL-----------------------MK 180
T Q KL +E+ T + +KE+ + K
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 181 E-----TEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALE-------YTIY 228
E TE R ++N+++ E++L+ EE +E+ + Q +K + E +
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCE 1086
Query: 229 NQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEK 288
+E+N+ L E K++T+ L + Q+ + K V L + +K
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTT------LNELQEQLKQK----SAHVNSLAQDETKLKAHL 1136
Query: 289 EQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE 348
E+L + + +K+ T L+ + EL +E+ KR + E L+ +E+ + L +
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLV----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192
Query: 349 PKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAIND 408
K N E + +L++ + D+ K+ E + ++ I+
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 409 KKRQIAAIHKDL-------EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNK 461
+ + + + L + EA + E+ N L+ + ++EE + + +K
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312
Query: 462 KDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRR 521
+ L +E+ L +E +QQA + K + + + K + I+++ + + +
Sbjct: 1313 IESLVTEKEALQKEGGNQQQAASEKESCITQLK--------KELSENINAVTLMKEELKE 1364
Query: 522 KGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNL 581
K + + + + N + + + + A + L DE ++L + ++
Sbjct: 1365 KKVE--ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY---DEEKCELLDQVQDLSF 1419
Query: 582 PGEVTFLPLNKLDVRDTAYPETNDAIPMIS--KLRYNPRFDKAFKHVFGKTLICRSMEVS 639
+V L K+ +A + +D S K + RF + ++ + I ++
Sbjct: 1420 --KVDTLSKEKI----SALEQVDDWSNKFSEWKKKAQSRFTQ-HQNTVKELQIQLELKSK 1472
Query: 640 TQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNEN 699
+ ++ + E DQ + R +D K E++ D K E++ LE +L
Sbjct: 1473 EAYEKDEQINLLKEELDQQNKR-------FDCLKG--EMEDDKSKMEKKESNLETELKSQ 1523
Query: 700 LRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRS 759
R +E + + I Q +++ + + + +D E K L +K Q ++ K
Sbjct: 1524 TARIME-LEDHITQKTIEIESLNEVLKNYNQQKDI---EHKELVQKLQHFQELGEEKDNR 1579
Query: 760 LQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERI 819
++ E + +E+ S+KAEL T +K ++ +N ++ ++E + L +R+
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELET---------KKKELEHVNLSVKS-KEEELKALEDRL 1629
Query: 820 KLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMAR 879
+ E E L +++ ++++L E + T S L +N ++++
Sbjct: 1630 ESESAAKLAE--LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 880 SEDLDNSIDKTEAGIKEL------QKSMERWKNME------------KEHMDAINHDTKE 921
L+ + E+ E K++ + E +E + + + E
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 922 LEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQ---------LFRKLEQC 972
EK+ R G ++KEE + E+ QE K + KQ L +LE+
Sbjct: 1748 KEKLLQRVG---QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 973 NTELKKYS-----HVNK-------KALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV 1020
N KKYS HV K +A N + +K ++ +E + + ++ ++
Sbjct: 1805 N---KKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 1021 LELRKYEAIQLTFKQVSKNFS--EVFQKLVPGGKATLVMKKGDVEGSQS 1067
+R+ E ++ ++++ + + Q++ K T ++++ E S+S
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Score = 83.2 bits (204), Expect = 1e-15
Identities = 173/928 (18%), Positives = 378/928 (40%), Gaps = 156/928 (16%)
Query: 220 RRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRD--AQQDARDKMEDIERQVREL 277
+ +L T + LN R LD +A + + + D D+ +K + I+R +R +
Sbjct: 90 KESLVRTSSRESLN--RLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQR-LRRM 146
Query: 278 KTKISAMKEEKEQLSAERQEQIKQRTKLE-----------LKAKDLQDELAGNSEQRKRL 326
+ +S+ + + +L Q +++ KL+ + +L++EL + + +K L
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 327 LKERQKLLEKIEEKQKELAETEPKFNSVKEKEERG-----IARLAQATQERTDLYAKQGR 381
+E +EEK + ++ + + + +K++ G + + + + +++ K+
Sbjct: 207 QEEFD---ASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEEN 263
Query: 382 GSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDL 441
D K L++L Q + KRQ + + E +++K EQ L
Sbjct: 264 PESDGEPVVEDGTSVKTLETLQQRV---KRQENLLKRCKETIQSHK----EQCTLL---T 313
Query: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAAT 501
+E +A E+LD + E++ KD +E+ L + + + E LE+ + ++ A T
Sbjct: 314 SEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLI----EQLEQDKGMVIAET 369
Query: 502 GKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNN-------FECEPAFYTCVEVTA 554
+ + ++ + + R + I Q G E E A T +
Sbjct: 370 KRQMHETLEMKEEEIAQLRSR-IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 555 GNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLR 614
R +D + + E +++L E++ + K +V D + + I + KL
Sbjct: 429 ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV---KQEVVDVMKKSSEEQIAKLQKLH 485
Query: 615 YNPRFDKAFKHVFGKTLICRSMEVSTQLARAF---------------TMDCITLEGDQVS 659
K + K L R E Q+ A + + LE ++
Sbjct: 486 EKELARK--EQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 660 HRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRN---------------- 703
+ LT ++ +LQ++ + ELE+ L ++L+ N
Sbjct: 544 KKAILT----ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 704 ---------IERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFM 754
+E+ E++ L +Q + T+ K + + +EM+ L+EK +Q ++T +
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTE--KLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 755 P----------KQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEI 804
++ + ++LE L ++ ESL +EL L ++ LE++ + L D+
Sbjct: 658 KDKEIIFQAHIEEMNEKTLE-KLDVKQTELESLSSELSEVLKARHKLEEE--LSVLKDQT 714
Query: 805 RQLQQE-----NRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
+++QE + Q + + +++ II E + + DQ+ Q L+E +
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD----- 769
Query: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDT 919
K +K+ A E+L+ I ++E +++ ++ +++ + A + T
Sbjct: 770 -----------KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS----YQSATHEQT 814
Query: 920 KEL-EKMTNRQGMLLKKKEE---CMKKIRELGSLPQEAFEKYQT--LSLKQLFRKLEQCN 973
K E++ Q LL + E K++ E+ + ++ + + ++ L ++LE+ N
Sbjct: 815 KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 974 TEL----KKYSHVNKKALDQFVNFSEQKEKLIKRQE----ELDRGYKSIMELMNVLELRK 1025
+E+ K + V + L+ EQ ++++ +E ++ G K +E++ K
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 1026 YEAIQL-------TFKQVSKNFSEVFQK 1046
++I + FK K +V QK
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQK 962
Score = 73.9 bits (180), Expect = 8e-13
Identities = 163/823 (19%), Positives = 333/823 (40%), Gaps = 112/823 (13%)
Query: 314 DELAGNS-----EQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEK--------EER 360
++L GNS EQ + L+ ++ L K EL K+K +++
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 361 GIARLAQATQE-RTDLYAKQGRGSQF-TSKEERDKWI---KKELKSLDQAINDKKRQIAA 415
+ R+A+ +E + D AK+ +F S EE+D++I + ++ L Q + + +
Sbjct: 185 SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV 244
Query: 416 I--------HKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQS 467
+ ++ E N E + E + + ++ + + R+ +K K+ +QS
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS 304
Query: 468 ERNY---LWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGI 524
+ L E+ A Q+ L + ++LEK + L A K I D+ N + + KG
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG- 363
Query: 525 NQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGE 584
M E + + +E+ +E ++ +M GE
Sbjct: 364 ------------MVIAETKRQMHETLEM------------KEEEIAQLRSRIKQMTTQGE 399
Query: 585 VTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLAR 644
L K A+ E A+ K R KA KT+ S E L +
Sbjct: 400 E--LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 457
Query: 645 AFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNI 704
+ + E V + + + EL + ++ ++L E + E ++ +
Sbjct: 458 ELSR--VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL 515
Query: 705 ERINNEIDQLMNQMQQIETQQ-RKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQS- 762
E+ +E ++ + +Q E+ + + + +IL+E + QQ +T+ + L+S
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 575
Query: 763 LEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLE 822
LE SL ++ + L L + ++ + E V+ E+ L+ + L E KL+
Sbjct: 576 LEKSLQENKNQSKDLAVHLEAEK-NKHNKEITVMVEKHKTELESLKHQQDALWTE--KLQ 632
Query: 823 GIITRVETYLNENLRKRLDQVEQELNE---------LRETEGGTV--LTATTSELEAINK 871
+ + +T + E LR++ +Q ++ L + + E T+ L +ELE+++
Sbjct: 633 VLKQQYQTEM-EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
Query: 872 RVKDTMARSEDLDNSI----DKTEAGIKELQKSMERWKNME--------KEHMDAINHDT 919
+ + + L+ + D+T+ +EL+ M+ KN KEH +I
Sbjct: 692 ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
Query: 920 KELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKY 979
K L+ N+ +LLK++++ +K+ +A + +K+ +L+Q + +L +
Sbjct: 752 KALKDQINQLELLLKERDKHLKE--------HQAHVENLEADIKRSEGELQQASAKLDVF 803
Query: 980 SHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYE------------ 1027
+Q + EQ +L +Q+ LD + I+ V E+ +
Sbjct: 804 QSYQSATHEQTKAYEEQLAQL--QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Query: 1028 AIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDE 1070
+Q +Q+ K SE+ QK+ T V + +G++ Q++
Sbjct: 862 QVQDLMQQLEKQNSEMEQKV---KSLTQVYESKLEDGNKEQEQ 901
Score = 71.2 bits (173), Expect = 5e-12
Identities = 174/913 (19%), Positives = 361/913 (39%), Gaps = 165/913 (18%)
Query: 185 KREKINELLKYIEERLHTL----EEEKEELAQYQKWDKMRRALEYTIYNQ-ELNETRAKL 239
K I +L K + E ++ + EE KE+ + K L + N L+E A +
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIER-------QVRELKTKISAMKEEKEQLS 292
L R+ E+ +L D QD K++ + + QV + K S K++ +
Sbjct: 1397 SSL---RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453
Query: 293 AERQEQIKQ-RTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKF 351
+ Q +K+ + +LELK+K+ ++ +++ LLKE +++++ K + +
Sbjct: 1454 TQHQNTVKELQIQLELKSKEAYEK-----DEQINLLKE------ELDQQNKRFDCLKGEM 1502
Query: 352 NSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKR 411
K K E+ + L + +T ++ E+ E++SL++ + + +
Sbjct: 1503 EDDKSKMEKKESNLETELKSQT---------ARIMELEDHITQKTIEIESLNEVLKNYNQ 1553
Query: 412 QIAAIHKDL-----------EDTEANKEKNLEQYNKLDQDLNEVKARVE----ELDRKYY 456
Q HK+L E+ + ++ E+ L+ + +KA +E EL+
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 457 EVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVL 516
VK+K++EL++ + L E AAK +L++K + AA K +L+ ++
Sbjct: 1614 SVKSKEEELKALEDRLESES-------AAKLAELKRKAEQKIAAIKKQLLSQMEE----K 1662
Query: 517 DHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEF 576
+ +KG H+ + E HI++ S +
Sbjct: 1663 EEQYKKGTESHLSELNTKLQERERE------------------VHILEEKLKSVE----- 1699
Query: 577 NKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICR-- 634
+ E +P + +V E D+ + K Y + +++ K + +
Sbjct: 1700 ---SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK-TYEEKISVLQRNLTEKEKLLQRV 1755
Query: 635 SMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEE--LGEL 692
E ++ F M C Y R +LE + ++ E++ +G L
Sbjct: 1756 GQEKEETVSSHFEMRC-----------------QYQERLIKLE-HAEAKQHEDQSMIGHL 1797
Query: 693 EAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKT 752
+ +L E N + ++ Q + E + +A ++ L+ +KT
Sbjct: 1798 QEELEEK--------NKKYSLIVAQHVEKEGGKNNIQAKQN--------LENVFDDVQKT 1841
Query: 753 FMPKQRSLQSLEASLHAMES----TRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQ 808
K+ + Q LE + ++S +E + E+ L+ +++D N L+
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 809 QENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEA 868
+ + + +++ +E N+ L +L E+E +L G + +L
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHND-LEFKLAGAEREKQKL-----GKEIVRLQKDLRM 1955
Query: 869 INKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNR 928
+ K + + I K E + +K + +++E +H N K+L + N
Sbjct: 1956 LRKEHQQEL--------EILKKEYDQEREEKIKQEQEDLELKH----NSTLKQLMREFNT 2003
Query: 929 QGMLLKKKEECMKKIRELGSLPQEA----FEKYQTLSLKQLFRKLEQCNTELKKYSHVNK 984
Q L +K++E I+E + QE E +Q QL +K+ + + +LK+ + +
Sbjct: 2004 Q--LAQKEQELEMTIKETINKAQEVEAELLESHQE-ETNQLLKKIAEKDDDLKRTAKRYE 2060
Query: 985 KALDQFVNFSEQKEKLIKRQ-EELDRGYKSIMEL--------MNVLELRKYEAIQLTFKQ 1035
+ LD K + ++ Q EEL + Y+ +E + ++EL+ A + T
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120
Query: 1036 VSKNFSEVFQKLV 1048
SK + F++ +
Sbjct: 2121 DSKLKEQEFREQI 2133
Score = 65.1 bits (157), Expect = 4e-10
Identities = 131/722 (18%), Positives = 293/722 (40%), Gaps = 63/722 (8%)
Query: 154 QRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY 213
+ L++ E+ Y+ K+E I+L+KE ++ K + LK E + E+KE +
Sbjct: 1461 KELQIQLELKSKEAYE--KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 214 QKWDKMRRALEY-------TIYNQELNETRAKLDELS-AKRETSGEKSRQLRDAQQDARD 265
+ + R +E TI + LNE ++ + + +K + ++ ++ +
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 266 KMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325
++++ E ++ L+ ++ +MK E E E + E + K L+D L SE +
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL--ESESAAK 1636
Query: 326 LLKERQKLLEKIEEKQKE-LAETEPKFNSVKEKEERGIARLAQATQER-TDLYAKQGRGS 383
L + ++K +KI +K+ L++ E K K+ E ++ L QER +++ + +
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Query: 384 QFTSKEERDKWIKKELKSLDQAINDKKRQI-AAIHKDLEDTEANKEKNLEQYNKLDQDLN 442
S + + + K++ ++ + K E+ + ++NL + KL Q +
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756
Query: 443 EVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQ-------- 494
+ K EE ++E++ + E + + +++ +Q + +E+LE+K
Sbjct: 1757 QEK---EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVA 1813
Query: 495 QLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTA 554
Q + GK + ++ V D ++ Q + + E + EV
Sbjct: 1814 QHVEKEGGKNNIQAKQNLENVFDDVQK--TLQEKELTCQILEQKIKELDSCLVRQKEV-- 1869
Query: 555 GNRLFYHIVDSDEVSTK-----ILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPM 609
H V+ +E+++K L + + N P E+ L+ +++ P
Sbjct: 1870 ------HRVEMEELTSKYEKLQALQQMDGRNKPTEL-------LEENTEEKSKSHLVQPK 1916
Query: 610 ISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYY 669
+ D FK + ++ ++ R D L + L Y
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAER---EKQKLGKEIVR-LQKDLRMLRKEHQQELEILKKEYD 1972
Query: 670 DTRKSRL-ELQKDVR-KAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRK 727
R+ ++ + Q+D+ K L +L + N L + + + I + +N+ Q++E +
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE--L 2030
Query: 728 FKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLS 787
++ ++ +K + EK ++T + L + E + A ++ EL
Sbjct: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
Query: 788 QLSLEDQKRVD--ALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQ 845
+L E+ D + + QL Q+ + + ++K + ++ NL RL + E+
Sbjct: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI-----HNLEDRLKKYEK 2145
Query: 846 EL 847
+
Sbjct: 2146 NV 2147
Score = 55.8 bits (133), Expect = 2e-07
Identities = 91/444 (20%), Positives = 190/444 (42%), Gaps = 59/444 (13%)
Query: 89 LPIDKEEVSLRRVIGAKKDQY-FLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQM 147
L ++ + S++ + KK + ++ + +K + + LE S S + K Q
Sbjct: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647
Query: 148 ATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEK 207
A Q L + E ++ K+ + S + E K ++ + +EE+L ++E +
Sbjct: 1648 IAAIKKQLLSQMEEKE-----EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 208 EE----------LAQYQKWDK------MRRALE--YTIYNQELNETRAKLDELSAKRETS 249
E +A Y + ++ +++ E ++ + L E L + ++E +
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEET 1762
Query: 250 GEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKA 309
++R Q+ K+E E + E ++ I ++EE E+ + + + Q + E
Sbjct: 1763 VSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822
Query: 310 KDLQ--DELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQ 367
++Q L + ++ L+E++ + +E+K KEL V++KE +
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC-----LVRQKEVHRV----- 1872
Query: 368 ATQERTDLYAKQGRGSQFTSKEERDKWIKK--ELKSLDQAINDK-KRQIAAIHKDLE--- 421
+E T Y K Q + + + +++ E KS + K + A H DLE
Sbjct: 1873 EMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
Query: 422 -DTEANKEKNLEQYNKLDQDL----NEVKARVEELDRKY-----YEVKNKKDELQSERN- 470
E K+K ++ +L +DL E + +E L ++Y ++K ++++L+ + N
Sbjct: 1933 AGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNS 1992
Query: 471 ---YLWREENAEQQALAAKREDLE 491
L RE N + LA K ++LE
Sbjct: 1993 TLKQLMREFNTQ---LAQKEQELE 2013
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 104 bits (260), Expect = 4e-22
Identities = 186/935 (19%), Positives = 378/935 (40%), Gaps = 145/935 (15%)
Query: 153 SQRLKLLRE-VAGTRVYDERKEESISLMKETEGKREKI-----------NELLKYIEERL 200
S+R ++L++ V G R E + T K+E+I NE L E R
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 201 HTLEEEKEELAQYQ-KWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDA 259
L++EKE L + + + R +L L E R + L+ + G R +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESL--------LAEQRGQNLLLTNLQTIQGILERSETET 833
Query: 260 QQDARDKMEDIERQVRELKTKISAMKEEKEQLSA-------ERQEQIKQRTKLELKAKDL 312
+Q ++E +E ++ LK K+ E++ L+ + + Q+ T L L K+L
Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893
Query: 313 ----QDELAG------------NSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKE 356
Q E+A S+ +R K + E +++ +L +TE + N +KE
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 357 KEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAI 416
+ + + + Q T L + Q T EE K I+ LK + ++++ +
Sbjct: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVT--EEVRKNIEVRLKESAEFQTQLEKKLMEV 1011
Query: 417 HKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREE 476
K+ ++ + +K + +E ++Q L+E+K + + + E + S R +
Sbjct: 1012 EKEKQELQDDKRRAIES---MEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA-RRD 1067
Query: 477 NAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIV 536
EQ +A + ++ +++ +L AA +A+ + ++K+ + QH++
Sbjct: 1068 CQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS------VRQHLEETTQKAE 1121
Query: 537 MNNFECEPAFYT---------------CVEVTAGNRLFYHIVD--SDEVSTKI------- 572
EC+ ++ C ++ NRL + ++ SD+V +
Sbjct: 1122 SQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
Query: 573 ----LMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFG 628
L E K + L + + R+ ET + + LRY R + + +
Sbjct: 1182 LNVSLSEEGK----SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
Query: 629 KTLICRSMEVSTQL-ARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-----LQKDV 682
+ Q+ A+ ++ + + T K RLE +Q V
Sbjct: 1238 LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKV 1297
Query: 683 RKAEEE---LGELEAKLNEN----------LRRNIERINNEIDQLMNQMQQIETQQ-RKF 728
RK E + L E A+L+E L +++R L++Q + +T++ RK
Sbjct: 1298 RKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
Query: 729 KASRD-------SILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAEL 781
+ ++ + E+ LK + +S + Q +QSL+ L+ + + +E+++ +L
Sbjct: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
Query: 782 GT---DLLSQLSLEDQ-----KRVDALNDEIRQLQ--------------QENRQLLNERI 819
D+ ++ Q +R +E++ Q QE + E
Sbjct: 1418 DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQ 1477
Query: 820 KLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATT---SELEAINKRVKDT 876
+L+ + + ET +++L +++ +++ L+E +ETE + T SEL + + ++D
Sbjct: 1478 ELKETLNQAETK-SKSLESQVENLQKTLSE-KETEARNLQEQTVQLQSELSRLRQDLQDR 1535
Query: 877 MARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKK 936
+ E L I + E ++ +K++ K+ + TKE E++ R G L ++K
Sbjct: 1536 TTQEEQLRQQITEKE---EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQK 1592
Query: 937 EECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971
+E +I L S + + + + R LEQ
Sbjct: 1593 DELDVRITALKSQYEGRISRLERELREHQERHLEQ 1627
Score = 99.8 bits (247), Expect = 1e-20
Identities = 191/938 (20%), Positives = 370/938 (39%), Gaps = 127/938 (13%)
Query: 169 DERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTI- 227
+ +KEE L ++ G + L K++E+ L L+E KE+ A + +K L I
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME--EKFHNELNAHIK 284
Query: 228 ----YNQELNETRAKLDELSAKRET-------SGEKSRQLRD---AQQDARDKMED---- 269
Y +++ AK +EL+ E +GE ++ ++D + ++D+ME
Sbjct: 285 LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344
Query: 270 ----IERQVRELKTKISAMKEEKEQLSAERQEQIK--------------QRTKLELKAKD 311
+E+++ +SA K + LS E + + T+L +
Sbjct: 345 KIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVE 404
Query: 312 LQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQE 371
QD+L + KR+ K ++++++E K L ++ ++ +L QA +E
Sbjct: 405 TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464
Query: 372 RTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNL 431
L + ++ +S ERD + ++ + D +QI + +LE+ N
Sbjct: 465 IQRLQEDTDKANKQSSVLERDN------RRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
Query: 432 EQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLE 491
E+ + D + + E + + +N +ELQ + Q+ L A RE E
Sbjct: 519 EEVSSAD-----ISSSSEVISQHLVSYRN-IEELQQQ----------NQRLLVALRELGE 562
Query: 492 KKQQLLRAATGKAILN---GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYT 548
+++ + T I ++S L+ R+ QH IV +
Sbjct: 563 TREREEQETTSSKITELQLKLESALTELEQLRKS--RQHQMQLVDSIVRQ----RDMYRI 616
Query: 549 CVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIP 608
+ T G + H D+VS L K + P + T E A+
Sbjct: 617 LLSQTTGVAIPLHASSLDDVS---LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALK 673
Query: 609 MISKLRYNPRFDKAFKHVFGK-----------TLICRSMEVSTQL---ARAFTMDCITLE 654
+ ++ N + +KA L ++ ++STQL ++ + M L+
Sbjct: 674 QLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM----LQ 729
Query: 655 GDQVSHRGALTGGYYDTRKSRLELQK----------DVRKAEEELGELEAKLNENLRRNI 704
+ +R +T + +K QK D+R A E+L E + ENL++
Sbjct: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA-ENLKKEK 788
Query: 705 ERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLE 764
E + +L Q + + +QR ++ +L+ ++ ++ ++SE KQR +E
Sbjct: 789 EMLKLSEVRLSQQRESLLAEQR----GQNLLLTNLQTIQGILERSETE--TKQRLSSQIE 842
Query: 765 ASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGI 824
H + ++ L+ E+ +L+ Q L D RQL E LN + L+
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQ-----LLDTKRQLDTETNLHLNTKELLKNA 897
Query: 825 ITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLD 884
+ T L++ L +E ++ G + +++ + +++ T + DL
Sbjct: 898 QKEIAT-----LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
Query: 885 NSIDKTEAGIKELQ---KSMERWKNMEKEHMDAINHDTK-ELEKMTNRQGMLLKKKEECM 940
+ + + +++ Q S+E N EK+ + + + + L++ Q L KK E
Sbjct: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
Query: 941 KKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKL 1000
K+ +EL + A E + L +L + L E+++ AL ++
Sbjct: 1013 KEKQELQDDKRRAIESMEQ-QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQ 1071
Query: 1001 IKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSK 1038
K E Y+ ELM L EA+Q +QVSK
Sbjct: 1072 AKIAVEAQNKYE--RELM--LHAADVEALQAAKEQVSK 1105
Score = 79.0 bits (193), Expect = 3e-14
Identities = 190/927 (20%), Positives = 372/927 (40%), Gaps = 157/927 (16%)
Query: 173 EESISLMKETEGKREKI-NELLKYIEERLHTLEEEKEELA-QYQKWDKMRRALEYTI--Y 228
+E K+ + + EKI NE L+ ++E++ L + +++ Q K L+ + Y
Sbjct: 676 QEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGY 735
Query: 229 NQE---LNETRAKLDELSAKRETS-GEKSRQLRDAQQD---ARDKMEDIERQVRELKTKI 281
+E L+E KL + K+E ++ LR A + A + E+++++ LK
Sbjct: 736 RREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE 795
Query: 282 SAMKEEKEQLSAERQEQ--------------------IKQRT-----KLELKAKDLQDEL 316
+ +++E L AE++ Q KQR KLE + L+ +L
Sbjct: 796 VRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKL 855
Query: 317 AGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVK--EKEERGIARLAQATQERTD 374
EQR L + ++ ++ K++ ET N+ + + ++ IA L Q
Sbjct: 856 ENEVEQRHTLTRNLD--VQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
Query: 375 LYAKQ-----GRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEK 429
A Q G+G Q ++KE+ D + +L+ ++ +ND K + L+ + +N E+
Sbjct: 914 QVASQSSQRTGKG-QPSNKEDVDDLVS-QLRQTEEQVNDLKER-------LKTSTSNVEQ 964
Query: 430 NLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAE-QQALAAKRE 488
L++ LN+ K EE+ RK EV+ K E+AE Q L K
Sbjct: 965 YQAMVTSLEESLNKEKQVTEEV-RKNIEVRLK--------------ESAEFQTQLEKKLM 1009
Query: 489 DLEKKQQLLRAATGKAILNGIDSINKVLDHFRR--KGINQHVQNGYHGIVMNNFECEPAF 546
++EK++Q L+ +A I+S+ + L ++ + VQ + A
Sbjct: 1010 EVEKEKQELQDDKRRA----IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQAR 1065
Query: 547 YTCVE-----VTAGNR----LFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRD 597
C E V A N+ L H D + + +V+ + + + +
Sbjct: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAA----------KEQVSKMASVRQHLEE 1115
Query: 598 TAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQ 657
T + + K + R ++ K K +CR ++ Q D I D+
Sbjct: 1116 TTQKAESQLLEC--KASWEER-ERMLKDEVSKC-VCRCEDLEKQ--NRLLHDQIEKLSDK 1169
Query: 658 V------SHRGALTGGYYDTRKSR---LELQKDVRKAEEELGELEAKLNE----NLRRNI 704
V +G L + KS+ LE+ + +R+ E+E+ E ++ + R+ +
Sbjct: 1170 VVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR-EKEIAETRFEVAQVESLRYRQRV 1228
Query: 705 ERINNEIDQLMNQ--------------MQQIETQQRKFKASRDSILSEMKMLKEKRQQSE 750
E + E+ +L + M Q E +K + + + ++ KML+E++++ E
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE-TMNVVMETNKMLREEKERLE 1287
Query: 751 KTFMPKQRSLQSLEASLHAMESTRESLKAELG-TDLLSQLSLEDQKRVDALNDEIRQLQ- 808
+ Q ++ LE + ++ L + G +L ED KR A N + Q
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347
Query: 809 ----QENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRE--TEGGTVLTAT 862
+E R+LL+E+ E KR+ Q+ +E+ L+ LT
Sbjct: 1348 DPDTEEYRKLLSEK---------------EVHTKRIQQLTEEIGRLKAEIARSNASLTNN 1392
Query: 863 TSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKEL 922
+ ++++ + + E + +D I+E K++ + K + + + +
Sbjct: 1393 QNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQ 1452
Query: 923 EKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHV 982
+K+ +E ++E+ L +E + +T S K L ++E L +
Sbjct: 1453 DKVMETSAQSSGDHQEQHVSVQEMQEL-KETLNQAETKS-KSLESQVENLQKTLSEKETE 1510
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDR 1009
+ +Q V + +L RQ+ DR
Sbjct: 1511 ARNLQEQTVQLQSELSRL--RQDLQDR 1535
Score = 78.2 bits (191), Expect = 4e-14
Identities = 169/901 (18%), Positives = 364/901 (40%), Gaps = 104/901 (11%)
Query: 185 KREKINELLKYIEERLHT-LEEEKEEL----AQYQKWDKMRRALEYTIYNQELNETRAKL 239
+R ++N+L K ++ +L L +++ E+ +++K+ K+ +Y + L+ ++ +L
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKF-KVESEQQYFEIEKRLSHSQERL 68
Query: 240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQI 299
++ RE Q R ++E + Q++ L K ++ +++ A + +
Sbjct: 69 --VNETREC------------QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT 114
Query: 300 KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEE 359
+ + +LE + +DL S++ + L ++ ++L EK++E E + K + ++ +
Sbjct: 115 RTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
Query: 360 RGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKD 419
R + QE+ L+++ + W+ ELK+ + R+ +
Sbjct: 175 SVKYREKRLEQEKELLHSQ-------------NTWLNTELKTKTDELLALGREKG---NE 218
Query: 420 LEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAE 479
+ + + N E E+ ++L++ +N +K E L + ++ K E + ++ + + + E
Sbjct: 219 ILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNE 278
Query: 480 QQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHF--RRKGINQH---VQNGYHG 534
A K +L K A + ++ ++K+L K I H V+
Sbjct: 279 LNA-HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
Query: 535 IVMNNFE----CEPAFYTCVEVTAGNRLFYHIVDSDEVS--TKILMEFNKMNLPGEVTFL 588
+ E E ++ + + I+ +E++ + K+ PG
Sbjct: 338 MEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM---- 393
Query: 589 PLNKLDVRDTAYPETNDAIPMISKL---RYNPRFDKAFKHVFGKT-LICRSMEVSTQLAR 644
KL AY ET D + ++ KL R N D+ K V K ++ R E + +
Sbjct: 394 ---KLTELYNAYVETQDQL-LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449
Query: 645 AFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNI 704
A + LE K LQ+D KA ++ LE N + +
Sbjct: 450 AVASLSVKLE---------------QAMKEIQRLQEDTDKANKQSSVLERD-NRRMEIQV 493
Query: 705 ERINNEIDQLMNQMQQIETQQ--RKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQS 762
+ ++ +I L+ ++++ R + S I S +++ + S + Q+ Q
Sbjct: 494 KDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ-HLVSYRNIEELQQQNQR 552
Query: 763 LEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIK-- 820
L +L + TRE + E + +++L L+ + + L +++R+ +Q QL++ ++
Sbjct: 553 LLVALRELGETREREEQETTSSKITELQLKLESALTEL-EQLRKSRQHQMQLVDSIVRQR 611
Query: 821 -LEGIITRVETYLNENLR-KRLDQVEQELNELRETEGGTVLTATT----SELEAINKRVK 874
+ I+ T + L LD V R + TV T EAI K
Sbjct: 612 DMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIE--AK 669
Query: 875 DTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTK---ELEKMTNRQGM 931
+ + +++ + K +A +++Q E+ + ++++ D + +TK +L+ + R M
Sbjct: 670 AALKQLQEIFENYKKEKAENEKIQN--EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
Query: 932 LLKKKEECMKKIRELG---------SLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHV 982
L E ++I L + QE T L+ KL +
Sbjct: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
Query: 983 NKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSE 1042
+ V S+Q+E L+ Q + ++ + +LE + E Q Q+ K E
Sbjct: 788 KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
Query: 1043 V 1043
+
Sbjct: 848 I 848
Score = 77.0 bits (188), Expect = 1e-13
Identities = 196/954 (20%), Positives = 384/954 (40%), Gaps = 147/954 (15%)
Query: 153 SQRLKL-LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEE-EKEEL 210
+QRL + LRE+ TR ER+E+ E KI EL +E L LE+ K
Sbjct: 550 NQRLLVALRELGETR---EREEQ--------ETTSSKITELQLKLESALTELEQLRKSRQ 598
Query: 211 AQYQKWDKMRRALEYTIYNQELNETR--------AKLDELSAKRETSGEKSRQL--RDAQ 260
Q Q D + R + +Y L++T + LD++S + Q A
Sbjct: 599 HQMQLVDSIVRQRD--MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
Query: 261 QDARDKMEDIERQ--VRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAG 318
+ E IE + +++L+ K+EK + + EQ++ KL+ + DL+ +
Sbjct: 657 VPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE---KLQEQVTDLRSQNTK 713
Query: 319 NSEQRKRLLKERQKLLEKIEEKQKELA---ETEPKFNSVKEKEERGIARLAQATQERTD- 374
S Q K + L + +E ++E+ E K + +K+E+ I + Q + +
Sbjct: 714 ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEK 773
Query: 375 LYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKR-------QIAAIHKDLEDTEANK 427
L + R ++E K + L +++ ++R + I LE +E
Sbjct: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
Query: 428 EKNLE-QYNKLDQDLNEVKARVE-ELDRKYYEVKNKKDELQSERNYLWREENAE------ 479
++ L Q KL+ +++ +K ++E E+++++ +N +L + L E N
Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893
Query: 480 ----QQALAAKREDLEKKQQLLRAA----TGKAILNGIDSINKVLDHFRRKGINQHVQNG 531
Q+ +A ++ L + + + TGK + + ++ ++ R+ +
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 532 YHGIVMNNFECEPAFYTCVEVTAGN--RLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLP 589
+N E A T +E + ++ + + EV K EF + L ++ +
Sbjct: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF-QTQLEKKLMEVE 1012
Query: 590 LNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTM- 648
K +++D +S+L+ KTL EV L RA T
Sbjct: 1013 KEKQELQDDKRRAIESMEQQLSELK--------------KTLSSVQNEVQEALQRASTAL 1058
Query: 649 --------DC-----ITLEGDQVSHRG---------ALTGGYYDTRKS---RLELQKDVR 683
DC I +E R AL K R L++ +
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118
Query: 684 KAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK 743
KAE +L E +A E R + +E+ + + + + +E Q R + LS+ +
Sbjct: 1119 KAESQLLECKASWEERERM----LKDEVSKCVCRCEDLEKQNRLLHDQIEK-LSDKVVAS 1173
Query: 744 EKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLK-AELGTDLLSQLSLEDQKRVDALND 802
K + +S E L + R + AE ++ SL ++RV+ L
Sbjct: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLER 1233
Query: 803 EIRQLQQENRQLLNERIKL--------EGIITRVETY-----LNENLRKRLDQVEQELNE 849
E+++L Q++ E++++ E ++ + ET N+ LR+ +++EQ+L +
Sbjct: 1234 ELQEL-QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Query: 850 LRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEK 909
++ +++ + + + +L +A K L++ ++RWK
Sbjct: 1293 MQ------------AKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWK-ARN 1339
Query: 910 EHM--DAINHDTKELEKMTNRQGMLLKKKEECMKKIR----ELGSLPQEAFEKYQTLSLK 963
+H+ + DT+E K LL +KE K+I+ E+G L E +L+
Sbjct: 1340 QHLVSQQKDPDTEEYRK-------LLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN 1392
Query: 964 Q-LFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIME 1016
Q L + L++ +++ +K LD + ++K K I + +++ R YK+ E
Sbjct: 1393 QNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE 1446
Score = 73.9 bits (180), Expect = 8e-13
Identities = 158/759 (20%), Positives = 310/759 (40%), Gaps = 140/759 (18%)
Query: 173 EESISLMKE-TEGKREKINELLK-------YIEERLHTLEEEKEELAQYQKWDKMRRALE 224
EES++ K+ TE R+ I LK +E++L +E+EK+EL D RRA+E
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ-----DDKRRAIE 1027
Query: 225 YTIYNQELNETRAKLDELS---------AKRETSGEKSRQLRDAQQDARDKMEDIERQVR 275
Q+L+E + L + A S E+ + RD Q+ A+ +E + R
Sbjct: 1028 SM--EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQAR-RDCQEQAKIAVEAQNKYER 1084
Query: 276 ELK---TKISAMKEEKEQLS--AERQEQIKQRTK------LELKA------KDLQDELAG 318
EL + A++ KEQ+S A ++ +++ T+ LE KA + L+DE++
Sbjct: 1085 ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSK 1144
Query: 319 ------NSEQRKRLLKER-QKLLEKIEEKQKELAETEPKFNSVKE-KEERGIARLAQATQ 370
+ E++ RLL ++ +KL +K+ KE + + +E K + I + + +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 371 ERTDLYAKQGRGSQFTSKEERDK--WIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE 428
++ + +Q S R + +++EL+ L ++N ++ ++ K + E +
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 429 KN-------------LEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475
K E+ +L+QDL +++A+V +L+ ++ EL + L
Sbjct: 1265 KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGML--- 1321
Query: 476 ENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH--FRRKGINQHVQNGYH 533
AE++ L ED+++ + + + + K+L K I Q +
Sbjct: 1322 -QAEKKLL---EEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE--- 1374
Query: 534 GIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKL 593
+ + E A R + ++ + + + NK+ E L
Sbjct: 1375 ---IGRLKAEIA-----------RSNASLTNNQNLIQSLKEDLNKVRTEKETI---QKDL 1417
Query: 594 DVRDTAYPETNDAIPMISKL--RYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCI 651
D + E I + K+ RY ++++ K + ME S Q + +
Sbjct: 1418 DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL------KAQQDKVMETSAQSSGDHQEQHV 1471
Query: 652 TLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEI 711
+++ Q T +T+ LE Q V ++ L E E + NL+ ++ +E+
Sbjct: 1472 SVQEMQELKE---TLNQAETKSKSLESQ--VENLQKTLSEKETEAR-NLQEQTVQLQSEL 1525
Query: 712 DQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAME 771
+L +Q TQ+ + + + + EK +++ K + + + L +
Sbjct: 1526 SRLRQDLQDRTTQEEQLR----------QQITEKEEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 772 STRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETY 831
E LK G +L+ QK D L+ I L+ + EG I+R+E
Sbjct: 1576 KENEELKQRNG-------ALDQQK--DELDVRITALKSQ----------YEGRISRLERE 1616
Query: 832 LNENLRKRL---DQVEQELNELRETEGGTVLTATTSELE 867
L E+ + L D+ ++ N++ E + L T + E
Sbjct: 1617 LREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 49.3 bits (116), Expect = 2e-05
Identities = 53/214 (24%), Positives = 99/214 (46%), Gaps = 33/214 (15%)
Query: 170 ERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY--QKWDKMRRALEYTI 227
+ +E+ +S+ + E + E L E + +LE + E L + +K + R E T+
Sbjct: 1465 DHQEQHVSVQEMQE-----LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTV 1519
Query: 228 YNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEE 287
Q ELS R+ +++ Q +Q +K E + + K+KI+ +
Sbjct: 1520 QLQS---------ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGV 1570
Query: 288 KEQLSAERQEQIKQRT--------KLELKAKDLQDELAGNSEQRKRLLKERQ-KLLEKIE 338
K+QL+ E E++KQR +L+++ L+ + G + +R L+E Q + LE+ +
Sbjct: 1571 KDQLTKE-NEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Query: 339 EKQKELAETEPKFNSVKEKEERGIARLAQATQER 372
E Q EP N V E++ + + A+ ER
Sbjct: 1630 EPQ------EPS-NKVPEQQRQITLKTTPASGER 1656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,349,720
Number of Sequences: 37866
Number of extensions: 1865082
Number of successful extensions: 31981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 624
Number of HSP's successfully gapped in prelim test: 1376
Number of HSP's that attempted gapping in prelim test: 9665
Number of HSP's gapped (non-prelim): 10878
length of query: 1217
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1103
effective length of database: 13,930,794
effective search space: 15365665782
effective search space used: 15365665782
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.