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Search of human proteins with 4758438
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758438 glucagon-like peptide 2 receptor precursor [Homo
sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758438 glucagon-like peptide 2 receptor precursor [Homo sapi... 1146 0.0
gi|166795283 glucagon-like peptide 1 receptor [Homo sapiens] 375 e-104
gi|4503947 glucagon receptor [Homo sapiens] 353 2e-97
gi|4503999 gastric inhibitory polypeptide receptor [Homo sapiens] 346 4e-95
gi|114205383 secretin receptor precursor [Homo sapiens] 298 1e-80
gi|15619006 vasoactive intestinal peptide receptor 1 [Homo sapiens] 265 1e-70
gi|4506271 parathyroid hormone receptor 1 precursor [Homo sapiens] 262 7e-70
gi|21361557 vasoactive intestinal peptide receptor 2 [Homo sapiens] 258 1e-68
gi|29171759 adenylate cyclase activating polypeptide 1 (pituitar... 246 3e-65
gi|4826954 parathyroid hormone 2 receptor precursor [Homo sapiens] 243 4e-64
gi|58530851 growth hormone releasing hormone receptor isoform a ... 233 3e-61
gi|32307159 corticotropin releasing hormone receptor 2 [Homo sap... 191 1e-48
gi|19923245 corticotropin releasing hormone receptor 1 isoform 2... 186 5e-47
gi|5031621 calcitonin receptor-like [Homo sapiens] 185 1e-46
gi|4502547 calcitonin receptor [Homo sapiens] 180 3e-45
gi|58530853 growth hormone releasing hormone receptor isoform b ... 176 5e-44
gi|223717971 corticotropin releasing hormone receptor 1 isoform ... 171 2e-42
gi|223717985 corticotropin releasing hormone receptor 1 isoform ... 164 3e-40
gi|223717978 corticotropin releasing hormone receptor 1 isoform ... 161 1e-39
gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 87 5e-17
gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens] 70 4e-12
gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens] 70 4e-12
gi|68508955 CD97 antigen isoform 3 precursor [Homo sapiens] 69 1e-11
gi|17978489 CD97 antigen isoform 2 precursor [Homo sapiens] 69 1e-11
gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens] 69 1e-11
gi|148806925 EGF, latrophilin and seven transmembrane domain con... 67 3e-11
gi|163792198 latrophilin 3 precursor [Homo sapiens] 59 9e-09
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 58 2e-08
gi|23397681 egf-like module containing, mucin-like, hormone rece... 58 2e-08
gi|23397687 egf-like module containing, mucin-like, hormone rece... 58 2e-08
>gi|4758438 glucagon-like peptide 2 receptor precursor [Homo
sapiens]
Length = 553
Score = 1146 bits (2965), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS 60
MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
Sbjct: 1 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS 60
Query: 61 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS 120
IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
Sbjct: 61 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS 120
Query: 121 YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL 180
YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
Sbjct: 121 YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL 180
Query: 181 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS 240
MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
Sbjct: 181 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS 240
Query: 241 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW 300
KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
Sbjct: 241 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW 300
Query: 301 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK 360
PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
Sbjct: 301 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK 360
Query: 361 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI 420
ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
Sbjct: 361 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI 420
Query: 421 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK 480
QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK
Sbjct: 421 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK 480
Query: 481 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM 540
LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
Sbjct: 481 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM 540
Query: 541 ANTMEEILEESEI 553
ANTMEEILEESEI
Sbjct: 541 ANTMEEILEESEI 553
>gi|166795283 glucagon-like peptide 1 receptor [Homo sapiens]
Length = 463
Score = 375 bits (964), Expect = e-104
Identities = 195/422 (46%), Positives = 267/422 (63%), Gaps = 15/422 (3%)
Query: 47 APGRPFLTLVLLVSI------KQVTGSLLEETTRKWAQYKQACLRDLLKEP---SGIFCN 97
APG L L+LL + Q L ET +KW +Y++ C R L ++P + +FCN
Sbjct: 4 APGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCN 63
Query: 98 GTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDD 156
TFD+Y CWP PG+ V+V CP YLPW S G YR C A+G W +N++ W+D
Sbjct: 64 RTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDL 123
Query: 157 SECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMN 216
SEC E+ +++ LL L ++YTVGY+ S +L +A +LL R LHCTRNYIH+N
Sbjct: 124 SECEESKRGERSSPEEQLLF-LYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLN 182
Query: 217 LFASFILRTLAVLVKDVVFYNSYSKRPDNE--NGWMSYLSEMSTSCRSVQVLLHYFVGAN 274
LFASFILR L+V +KD YS +G +SY + S SCR V +L+ Y V AN
Sbjct: 183 LFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSY--QDSLSCRLVFLLMQYCVAAN 240
Query: 275 YLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTN 334
Y WLLVEG+YL+TLL +VL E+ ++ Y+ +GW P+LFVVPWG + E+ GCWT N
Sbjct: 241 YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN 300
Query: 335 GNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLL 394
N W IIR P++ + VNF IF++++ +++SKLKA+ MC D K RLAKSTL LIPLL
Sbjct: 301 SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL 360
Query: 395 GVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRF 454
G HE++F+F+ D+ G + I+LF +L+ +SF G +VA+ Y F N EV+ E RK W R+
Sbjct: 361 GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW 420
Query: 455 LL 456
L
Sbjct: 421 RL 422
>gi|4503947 glucagon receptor [Homo sapiens]
Length = 477
Score = 353 bits (906), Expect = 2e-97
Identities = 186/419 (44%), Positives = 259/419 (61%), Gaps = 10/419 (2%)
Query: 48 PGRPFLTLVLLVSIKQVTGS--LLEETTRKWAQYKQACLRDL--LKEPSGIFCNGTFDQY 103
P RP L L+LL++ + S +++ KW Y C +L L P+ + CN TFD+Y
Sbjct: 6 PQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKY 65
Query: 104 VCWPHSSPGNVS--VPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECS- 160
CWP +P N + + CP YLPW + ++ C G W W+D S+C
Sbjct: 66 SCWP-DTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQP-WRDASQCQM 123
Query: 161 ENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFAS 220
+ + + + S+ Q+MYTVGYS SL +L LAL +L L KLHCTRN IH NLFAS
Sbjct: 124 DGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFAS 183
Query: 221 FILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTS-CRSVQVLLHYFVGANYLWLL 279
F+L+ +VLV D + YS++ ++ ++LS+ + + CR V + Y + ANY WLL
Sbjct: 184 FVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLL 243
Query: 280 VEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKI 339
VEGLYLH LL LPER + YL +GW P+LFVVPW + EN CWT+N N
Sbjct: 244 VEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGF 303
Query: 340 WWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEI 399
WWI+R P+ L + +NFFIF++I++LL++KL+A QM DYK+RLAKSTL LIPLLGVHE+
Sbjct: 304 WWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEV 363
Query: 400 LFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLAR 458
+F+F+TD+ +G + +LF L LSSF G LVA+ Y F N EV++ELR+ W R+ L +
Sbjct: 364 VFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK 422
>gi|4503999 gastric inhibitory polypeptide receptor [Homo sapiens]
Length = 466
Score = 346 bits (887), Expect = 4e-95
Identities = 180/423 (42%), Positives = 258/423 (60%), Gaps = 22/423 (5%)
Query: 51 PFLTLVLLVSI------KQVTGSLLE---ETTRKWAQYKQACLRDLL--KEPSGIFCNGT 99
P L L+L +S+ + TGS + E ++W +Y++ C L + PSG+ CNG+
Sbjct: 5 PILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGS 64
Query: 100 FDQYVCWPHSSPGNVS-VPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSE 158
FD YVCW +++P + CP YLPW ++G R C + G W +W+D ++
Sbjct: 65 FDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-------GLWRDHTQ 117
Query: 159 CSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLF 218
C + +D+ +L LQ+MYTVGYS SL +L LAL +L R+LHCTRNYIH+NLF
Sbjct: 118 CENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLF 177
Query: 219 ASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWL 278
SF+LR A+L +D + D ++ ++ +CR+ Q++ Y VGANY WL
Sbjct: 178 TSFMLRAAAILSRDRLLPRPGPYLGDQA---LALWNQALAACRTAQIVTQYCVGANYTWL 234
Query: 279 LVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKK 338
LVEG+YLH+LL E + YLLLGW P LFV+PW R ENT CW N K
Sbjct: 235 LVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKA 294
Query: 339 IWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHE 398
IWWIIR P+++ + +NF IF++IL +L+SKL+ QM RDY+ RLA+STL L+PLLGVHE
Sbjct: 295 IWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHE 354
Query: 399 ILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLAR 458
++F+ +T++Q G + +L ++ LSSF GFLV++ Y F N EV++E+R+ W L R
Sbjct: 355 VVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRR 414
Query: 459 HSG 461
G
Sbjct: 415 SLG 417
>gi|114205383 secretin receptor precursor [Homo sapiens]
Length = 440
Score = 298 bits (762), Expect = 1e-80
Identities = 168/422 (39%), Positives = 240/422 (56%), Gaps = 34/422 (8%)
Query: 48 PGRPFLTLVLLVSIKQVTGSL--LEETTRKWAQYKQACLRDLLKEPSGIF--------CN 97
P + L VLL TG+L L + + + + CL++L +E +G C
Sbjct: 8 PLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCE 67
Query: 98 GTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDD 156
G +D CWP S PG V V CP +L + + G +R+C G +T + +
Sbjct: 68 GMWDNISCWPSSVPGRMVEVECPRFLRMLTSRN-GSLFRNCTQDGWSETFP------RPN 120
Query: 157 SECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMN 216
C N + N R++ L L++MYTVGYS SL+ L +AL +L R+LHCTRNYIHM+
Sbjct: 121 LACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMH 180
Query: 217 LFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYL 276
LF SFILR L+ +KD V ++S ++Y C+ V VL Y + ANY
Sbjct: 181 LFVSFILRALSNFIKDAVLFSSDD---------VTYCDAHRAGCKLVMVLFQYCIMANYS 231
Query: 277 WLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGN 336
WLLVEGLYLHTLL + ER+ ++ GW P +FV W AR LE+ GCW N N
Sbjct: 232 WLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVGCWDINAN 291
Query: 337 KKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKY--RLAKSTLVLIPLL 394
IWWIIRGP++L + +NF +F+ IL++L+ KL+ + + + RLA+STL+LIPL
Sbjct: 292 ASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTLLLIPLF 351
Query: 395 GVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRF 454
G+H I+F+F +D +E I+LF +L L SF G +VA+ Y F NGEV+ E++K W ++
Sbjct: 352 GIHYIVFAFSPEDAME-----IQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQW 406
Query: 455 LL 456
L
Sbjct: 407 HL 408
>gi|15619006 vasoactive intestinal peptide receptor 1 [Homo sapiens]
Length = 457
Score = 265 bits (676), Expect = 1e-70
Identities = 155/385 (40%), Positives = 214/385 (55%), Gaps = 28/385 (7%)
Query: 78 QYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSV-PCPSYLPWWSEESSGRAYRH 136
Q+KQ CL + E I C+ +D CWP + G V V CP +S R
Sbjct: 46 QHKQ-CLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRS 104
Query: 137 CLAQGTWQTIENAT---DIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISL 193
C +G W +E DD S + +Q Y + T YT+GY SL +L
Sbjct: 105 CTDEG-WTHLEPGPYPIACGLDDKAASLD---EQQTMFYGSVKT---GYTIGYGLSLATL 157
Query: 194 FLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYL 253
+A +L RKLHCTRNYIHM+LF SFILR AV +KD+ ++S G
Sbjct: 158 LVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDS---------GESDQC 208
Query: 254 SEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVL 313
SE S C++ V Y V AN+ WLLVEGLYL+TLL + ER+ + Y+L+GW P
Sbjct: 209 SEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPST 268
Query: 314 FVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQ 373
F + W AR H E+ GCW T N +WWII+GP++ + VNF +F+ I+++L+ KL+
Sbjct: 269 FTMVWTIARIHFEDYGCWDTI-NSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPD 327
Query: 374 MCFRDYK--YRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFL 431
+ D RLA+STL+LIPL GVH I+F+F D+ F +++ +L + SF GF+
Sbjct: 328 IRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDN----FKPEVKMVFELVVGSFQGFV 383
Query: 432 VALQYGFANGEVKAELRKYWVRFLL 456
VA+ Y F NGEV+AELR+ W R+ L
Sbjct: 384 VAILYCFLNGEVQAELRRKWRRWHL 408
>gi|4506271 parathyroid hormone receptor 1 precursor [Homo sapiens]
Length = 593
Score = 262 bits (669), Expect = 7e-70
Identities = 148/381 (38%), Positives = 216/381 (56%), Gaps = 27/381 (7%)
Query: 96 CNGTFDQYVCWPHSSPGNV-SVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQ 154
C +D +CWP +PG V +VPCP Y+ + G AYR C G+W+ + W
Sbjct: 108 CLPEWDHILCWPLGAPGEVVAVPCPDYI--YDFNHKGHAYRRCDRNGSWELVPGHNRTWA 165
Query: 155 DDSECSENHSFKQNVDRYA-LLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYI 213
+ SEC + F N R + L ++YTVGYS SL SL +A+ +L + R+LHCTRNYI
Sbjct: 166 NYSECVK---FLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYI 222
Query: 214 HMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTS-------------C 260
HM+LF SF+LR +++ VKD V Y+ + + E L ++ + C
Sbjct: 223 HMHLFLSFMLRAVSIFVKDAVLYSG-ATLDEAERLTEEELRAIAQAPPPPATAAAGYAGC 281
Query: 261 RSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGF 320
R YF+ NY W+LVEGLYLH+L+ E++ + + GW P +FV W
Sbjct: 282 RVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVS 341
Query: 321 ARAHLENTGCW-TTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQ--MCFR 377
RA L NTGCW ++GNKK WII+ P++ + +NF +F+ I+++L +KL+ C
Sbjct: 342 VRATLANTGCWDLSSGNKK--WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDT 399
Query: 378 DYKYR-LAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQY 436
+YR L KSTLVL+PL GVH I+F +V G +++ ++ +SF GF VA+ Y
Sbjct: 400 RQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIY 459
Query: 437 GFANGEVKAELRKYWVRFLLA 457
F NGEV+AE++K W R+ LA
Sbjct: 460 CFCNGEVQAEIKKSWSRWTLA 480
>gi|21361557 vasoactive intestinal peptide receptor 2 [Homo sapiens]
Length = 438
Score = 258 bits (658), Expect = 1e-68
Identities = 148/386 (38%), Positives = 216/386 (55%), Gaps = 36/386 (9%)
Query: 96 CNGTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQ 154
C+G +D CW ++ G V+VPCP + ++ G ++C + G +T + D
Sbjct: 52 CSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKA-GNISKNCTSDGWSETFPDFVDAC- 109
Query: 155 DDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIH 214
+S ++ + ++ +YT+GYS SL+SL +L RKLHCTRNYIH
Sbjct: 110 -------GYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIH 162
Query: 215 MNLFASFILRTLAVLVKDVVFYNSYSKR--PDNENGWMSYLSEMSTSCRSVQVLLHYFVG 272
+NLF SFILR ++VLVKD V Y+S PD + W+ C+ V L Y +
Sbjct: 163 LNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVG--------CKLSLVFLQYCIM 214
Query: 273 ANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWT 332
AN+ WLLVEGLYLHTLL +LP RR + YLL+GW P + + W AR +LE+TGCW
Sbjct: 215 ANFFWLLVEGLYLHTLLV-AMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWD 273
Query: 333 TNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRD---YKYRLAKSTLV 389
TN + WW+IR P+++ + VNF +F+ I+++L+ KL + + D YK RLAKSTL+
Sbjct: 274 TNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYK-RLAKSTLL 332
Query: 390 LIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRK 449
LIPL GVH ++F+ + ++ +L L SF G +VA+ Y F N EV+ EL++
Sbjct: 333 LIPLFGVHYMVFAVFP----ISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKR 388
Query: 450 YWVRFLLARHSGCRACVLGKDFRFLG 475
W S C +D+R G
Sbjct: 389 KW-------RSRCPTPSASRDYRVCG 407
>gi|29171759 adenylate cyclase activating polypeptide 1 (pituitary)
receptor type I precursor [Homo sapiens]
Length = 468
Score = 246 bits (629), Expect = 3e-65
Identities = 143/389 (36%), Positives = 212/389 (54%), Gaps = 44/389 (11%)
Query: 96 CNGTFDQYVCWPHSSPGN-VSVPCPSYL------PWWSEESSGRA--------------- 133
C G +D CW + G V V CP W E+ G +
Sbjct: 54 CPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGV 113
Query: 134 -YRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLIS 192
R+C G + + D D SE + D Y L +++ +YTVGYS SL++
Sbjct: 114 VSRNCTEDGWSEPFPHYFDACGFDEYESETG----DQDYYYL--SVKALYTVGYSTSLVT 167
Query: 193 LFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSY 252
L A+ +L RKLHCTRN+IHMNLF SF+LR ++V +KD + Y D+ + ++S
Sbjct: 168 LTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILY----AEQDSNHCFIS- 222
Query: 253 LSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPV 312
+ C++V V HY V +NY WL +EGLYL TLL T PERR + Y ++GW P
Sbjct: 223 ----TVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPT 278
Query: 313 LFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAH 372
+ V W R + ++TGCW N + +WW+I+GP++ + VNF +F+ I+ +L+ KL++
Sbjct: 279 VCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSP 338
Query: 373 QMCFRDYK--YRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGF 430
M + RLA+STL+LIPL G+H +F+F E +K RL +L L SF GF
Sbjct: 339 DMGGNESSIYLRLARSTLLLIPLFGIHYTVFAF----SPENVSKRERLVFELGLGSFQGF 394
Query: 431 LVALQYGFANGEVKAELRKYWVRFLLARH 459
+VA+ Y F NGEV+AE+++ W + + R+
Sbjct: 395 VVAVLYCFLNGEVQAEIKRKWRSWKVNRY 423
>gi|4826954 parathyroid hormone 2 receptor precursor [Homo sapiens]
Length = 550
Score = 243 bits (619), Expect = 4e-64
Identities = 135/376 (35%), Positives = 201/376 (53%), Gaps = 18/376 (4%)
Query: 96 CNGTFDQYVCWPHSSPGNVS-VPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQ 154
C +D +CWP + G +S VPCP Y+ + G A+RHC GTW + + W
Sbjct: 63 CFPEWDGLICWPRGTVGKISAVPCPPYI--YDFNHKGVAFRHCNPNGTWDFMHSLNKTWA 120
Query: 155 DDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIH 214
+ S+C ++ + L +MYTVGYS S SL +A+ ++ + R+LHCTRNYIH
Sbjct: 121 NYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIH 180
Query: 215 MNLFASFILRTLAVLVKDVVFYNSYSKR----------PDNENGWMSYLSEMSTSCRSVQ 264
M+LF SF+LR ++ VKD V + + P N S C+
Sbjct: 181 MHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAV 240
Query: 265 VLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAH 324
V+ YF+ NY W+LVEGLYLH L+ + + ++L+GW FP FV W ARA
Sbjct: 241 VMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARAT 300
Query: 325 LENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYK--YR 382
L + CW + I WI + P++ + +NF +FL +++L +K+ D + YR
Sbjct: 301 LADARCWELSAG-DIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYR 359
Query: 383 -LAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANG 441
LAKSTLVL+ + GVH I+F + G IR+ +L +SF GF V++ Y + NG
Sbjct: 360 KLAKSTLVLVLVFGVHYIVFVCL-PHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNG 418
Query: 442 EVKAELRKYWVRFLLA 457
EV+AE++K W R+ L+
Sbjct: 419 EVQAEVKKMWSRWNLS 434
>gi|58530851 growth hormone releasing hormone receptor isoform a
precursor [Homo sapiens]
Length = 423
Score = 233 bits (594), Expect = 3e-61
Identities = 136/376 (36%), Positives = 205/376 (54%), Gaps = 26/376 (6%)
Query: 80 KQACLRDLLKEPSGIF-CNGTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHC 137
+ ACL+ + P+ C T+D +CWP + G V++PCP + +S ES G R C
Sbjct: 38 ESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSES-GAVKRDC 96
Query: 138 LAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLAL 197
G W + C + Y ST++++YTVG+S S+++LF+A+
Sbjct: 97 TITG-WSEPFPPYPV-----ACPVPLELLAEEESY--FSTVKIIYTVGHSISIVALFVAI 148
Query: 198 TLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMS 257
T+L+ LR+LHC RNY+H LF +FIL+ AV +KD ++S + S +
Sbjct: 149 TILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDT---------DHCSFST 199
Query: 258 TSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVP 317
C+ H+ N+ WLL E +YL+ LL T RR + +L GW PVLF
Sbjct: 200 VLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGT 259
Query: 318 WGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQ--MC 375
W + E+ CW + WWII+GP++L V VNF +FL I+++L+ KL+ Q +
Sbjct: 260 WVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLH 319
Query: 376 FRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQ 435
+ +RL+KSTL LIPL G+H I+F+F+ D+ G IRL ++L L SF GF+VA+
Sbjct: 320 TQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLG----IRLPLELGLGSFQGFIVAIL 375
Query: 436 YGFANGEVKAELRKYW 451
Y F N EV+ E+ + W
Sbjct: 376 YCFLNQEVRTEISRKW 391
>gi|32307159 corticotropin releasing hormone receptor 2 [Homo
sapiens]
Length = 411
Score = 191 bits (486), Expect = 1e-48
Identities = 118/364 (32%), Positives = 184/364 (50%), Gaps = 29/364 (7%)
Query: 95 FCNGTFDQY-VCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDI 152
+CN T DQ CWP S+ G V PCP Y ++ AYR CL GTW + N
Sbjct: 39 YCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINY--- 95
Query: 153 WQDDSECSENHSFKQNVDRYALLSTLQLMYT-VGYSFSLISLFLALTLLLFLRKLHCTRN 211
S+C KQ +Y L + L+ +G+ S+ +L A L L LR + C RN
Sbjct: 96 ----SQCEPILDDKQR--KYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRN 149
Query: 212 YIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFV 271
IH NL +FILR + + +V + + ++ W CR + + +YFV
Sbjct: 150 VIHWNLITTFILRNVMWFLLQLVDHEVH----ESNEVW----------CRCITTIFNYFV 195
Query: 272 GANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCW 331
N+ W+ VEG YLHT + T ER +L +GW P +V W + + EN CW
Sbjct: 196 VTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCW 255
Query: 332 -TTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVL 390
+ +I +GP++L + +NF I+++L++KL+A + K+TLVL
Sbjct: 256 FGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVL 315
Query: 391 IPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKY 450
+PLLG+ +LF F+ + + ++++ ++ L SF GF V++ Y F NGEV++ +RK
Sbjct: 316 LPLLGITYMLF-FVNPGE-DDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKR 373
Query: 451 WVRF 454
W R+
Sbjct: 374 WHRW 377
>gi|19923245 corticotropin releasing hormone receptor 1 isoform 2
[Homo sapiens]
Length = 415
Score = 186 bits (472), Expect = 5e-47
Identities = 128/415 (30%), Positives = 199/415 (47%), Gaps = 45/415 (10%)
Query: 49 GRPFLTLV---LLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQY-V 104
G P L LV LL+ + V+ SL ++ + L SG+ CN + D
Sbjct: 3 GHPQLRLVKALLLLGLNPVSASLQDQHCESLS---------LASNISGLQCNASVDLIGT 53
Query: 105 CWPHSSPGNVSV-PCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSE-- 161
CWP S G + V PCP++ ++ YR CLA G+W N SEC E
Sbjct: 54 CWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNY-------SECQEIL 106
Query: 162 NHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASF 221
N K V + + ++ +G+ SL++L +A L L LR + C RN IH NL ++F
Sbjct: 107 NEEKKSKVHYHVAV----IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAF 162
Query: 222 ILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVE 281
ILR V + + + GW CR V +YF N+ W+ E
Sbjct: 163 ILRNATWFVVQLTMSPEVHQ---SNVGW----------CRLVTAAYNYFHVTNFFWMFGE 209
Query: 282 GLYLHTLLEPTVLPER-RLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCW-TTNGNKKI 339
G YLHT + T +R R W ++ +GW P +V W + + +N CW
Sbjct: 210 GCYLHTAIVLTYSTDRLRKW-MFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYT 268
Query: 340 WWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEI 399
+I +GPM+L + +NF I+++L++KL+A + K+TLVL+PLLG+ +
Sbjct: 269 DYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYM 328
Query: 400 LFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRF 454
LF F+ + E ++++ ++ L SF GF V++ Y F N EV++ +RK W R+
Sbjct: 329 LF-FVNPGEDE-VSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRW 381
>gi|5031621 calcitonin receptor-like [Homo sapiens]
Length = 461
Score = 185 bits (469), Expect = 1e-46
Identities = 111/383 (28%), Positives = 194/383 (50%), Gaps = 29/383 (7%)
Query: 77 AQYK--QACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVP-CPSYLPWWSEESSGRA 133
AQY+ Q ++D +++ G++CN T+D ++CW + G S+ CP Y + + S +
Sbjct: 44 AQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDF--DPSEKV 101
Query: 134 YRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYT--VGYSFSLI 191
+ C G W + W + ++C+ N K + + L L Y +G+ S+
Sbjct: 102 TKICDQDGNWFRHPASNRTWTNYTQCNVNTHEK-------VKTALNLFYLTIIGHGLSIA 154
Query: 192 SLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMS 251
SL ++L + + + L C R +H NLF SF+ ++ ++ N+ + N
Sbjct: 155 SLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNP----- 209
Query: 252 YLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFP 311
SC+ Q + Y +G NY W+L EG+YLHTL+ V E++ Y LGW FP
Sbjct: 210 ------VSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFP 263
Query: 312 VLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKA 371
++ AR+ N CW ++ + + +II GP+ + VN F L I+++LI+KLK
Sbjct: 264 LIPACIHAIARSLYYNDNCWISS-DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKV 322
Query: 372 HQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFL 431
+ + ++TL+L+PLLG+ +L + + ++ A+ + +I L F G L
Sbjct: 323 THQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI---AEEVYDYIMHILMHFQGLL 379
Query: 432 VALQYGFANGEVKAELRKYWVRF 454
V+ + F NGEV+A LR+ W ++
Sbjct: 380 VSTIFCFFNGEVQAILRRNWNQY 402
>gi|4502547 calcitonin receptor [Homo sapiens]
Length = 474
Score = 180 bits (456), Expect = 3e-45
Identities = 113/384 (29%), Positives = 193/384 (50%), Gaps = 31/384 (8%)
Query: 77 AQYKQACLRDLLKEPS----GIFCNGTFDQYVCWPHSSPGNVSVP-CPSYLPWWSEESSG 131
AQYK C + + P+ G +CN T+D ++CW + G +S CP Y P + + S
Sbjct: 51 AQYK--CYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDF--DPSE 106
Query: 132 RAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLI 191
+ ++C +G W W + + C+ +F + A + L + VG+S S+
Sbjct: 107 KVTKYCDEKGVWFKHPENNRTWSNYTMCN---AFTPEKLKNAYV--LYYLAIVGHSLSIF 161
Query: 192 SLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDV-VFYNSYSKRPDNENGWM 250
+L ++L + +F R L C R +H N+F ++IL ++ +++ V V N R D
Sbjct: 162 TLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRD------ 215
Query: 251 SYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAF 310
SC+ + Y + NY W+L EG+YLHTL+ V E++ Y LLGW F
Sbjct: 216 ------PVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGF 269
Query: 311 PVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLK 370
P++ RA N CW + + +II GP+M + VNFF L I+++L++K++
Sbjct: 270 PLVPTTIHAITRAVYFNDNCW-LSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMR 328
Query: 371 AHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGF 430
+ K+T++L+PLLG+ ++F + +++ G I ++ +L F GF
Sbjct: 329 ETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLG---KIYDYVMHSLIHFQGF 385
Query: 431 LVALQYGFANGEVKAELRKYWVRF 454
VA Y F N EV+ +++ W +F
Sbjct: 386 FVATIYCFCNNEVQTTVKRQWAQF 409
>gi|58530853 growth hormone releasing hormone receptor isoform b
precursor [Homo sapiens]
Length = 337
Score = 176 bits (446), Expect = 5e-44
Identities = 101/296 (34%), Positives = 154/296 (52%), Gaps = 20/296 (6%)
Query: 80 KQACLRDLLKEPSGIF-CNGTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHC 137
+ ACL+ + P+ C T+D +CWP + G V++PCP + +S ES G R C
Sbjct: 38 ESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSES-GAVKRDC 96
Query: 138 LAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLAL 197
G W + C + Y ST++++YTVG+S S+++LF+A+
Sbjct: 97 TITG-WSEPFPPYPV-----ACPVPLELLAEEESY--FSTVKIIYTVGHSISIVALFVAI 148
Query: 198 TLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMS 257
T+L+ LR+LHC RNY+H LF +FIL+ AV +KD ++S + S +
Sbjct: 149 TILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDT---------DHCSFST 199
Query: 258 TSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVP 317
C+ H+ N+ WLL E +YL+ LL T RR + +L GW PVLF
Sbjct: 200 VLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGT 259
Query: 318 WGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQ 373
W + E+ CW + WWII+GP++L V VNF +FL I+++L+ KL+ Q
Sbjct: 260 WVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQ 315
>gi|223717971 corticotropin releasing hormone receptor 1 isoform 1
[Homo sapiens]
Length = 444
Score = 171 bits (432), Expect = 2e-42
Identities = 128/444 (28%), Positives = 199/444 (44%), Gaps = 74/444 (16%)
Query: 49 GRPFLTLV---LLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQY-V 104
G P L LV LL+ + V+ SL ++ + L SG+ CN + D
Sbjct: 3 GHPQLRLVKALLLLGLNPVSASLQDQHCESLS---------LASNISGLQCNASVDLIGT 53
Query: 105 CWPHSSPGNVSV-PCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSE-- 161
CWP S G + V PCP++ ++ YR CLA G+W N SEC E
Sbjct: 54 CWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNY-------SECQEIL 106
Query: 162 NHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFL------------------ 203
N K V + + ++ +G+ SL++L +A L L L
Sbjct: 107 NEEKKSKVHYHVAV----IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVG 162
Query: 204 -----------RKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSY 252
R + C RN IH NL ++FILR V + + + GW
Sbjct: 163 APWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQ---SNVGW--- 216
Query: 253 LSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER-RLWPRYLLLGWAFP 311
CR V +YF N+ W+ EG YLHT + T +R R W ++ +GW P
Sbjct: 217 -------CRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKW-MFICIGWGVP 268
Query: 312 VLFVVPWGFARAHLENTGCW-TTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLK 370
+V W + + +N CW +I +GPM+L + +NF I+++L++KL+
Sbjct: 269 FPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLR 328
Query: 371 AHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGF 430
A + K+TLVL+PLLG+ +LF F+ + E ++++ ++ L SF GF
Sbjct: 329 ASTTSETIQYRKAVKATLVLLPLLGITYMLF-FVNPGEDE-VSRVVFIYFNSFLESFQGF 386
Query: 431 LVALQYGFANGEVKAELRKYWVRF 454
V++ Y F N EV++ +RK W R+
Sbjct: 387 FVSVFYCFLNSEVRSAIRKRWHRW 410
>gi|223717985 corticotropin releasing hormone receptor 1 isoform 4
[Homo sapiens]
Length = 401
Score = 164 bits (414), Expect = 3e-40
Identities = 121/415 (29%), Positives = 191/415 (46%), Gaps = 59/415 (14%)
Query: 49 GRPFLTLV---LLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQY-V 104
G P L LV LL+ + V+ SL ++ + L SG+ CN + D
Sbjct: 3 GHPQLRLVKALLLLGLNPVSASLQDQHCESLS---------LASNISGLQCNASVDLIGT 53
Query: 105 CWPHSSPGNVSV-PCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSE-- 161
CWP S G + V PCP++ ++ YR CLA G+W N SEC E
Sbjct: 54 CWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNY-------SECQEIL 106
Query: 162 NHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASF 221
N K V + + ++ +G+ SL++L +A L L LR + C RN IH NL ++F
Sbjct: 107 NEEKKSKVHYHVAV----IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAF 162
Query: 222 ILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVE 281
ILR V + + + GW CR V +YF N+ W+ E
Sbjct: 163 ILRNATWFVVQLTMSPEVHQ---SNVGW----------CRLVTAAYNYFHVTNFFWMFGE 209
Query: 282 GLYLHTLLEPTVLPER-RLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCW-TTNGNKKI 339
G YLHT + T +R R W ++ +GW P +V W + + +N CW
Sbjct: 210 GCYLHTAIVLTYSTDRLRKW-MFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYT 268
Query: 340 WWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEI 399
+I +GPM+L + +NF I+++L++KL+A + K+TLVL+PLLG+ +
Sbjct: 269 DYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYM 328
Query: 400 LFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRF 454
LF F+ + E ++++ ++ L SF +V++ +RK W R+
Sbjct: 329 LF-FVNPGEDE-VSRVVFIYFNSFLESF--------------QVRSAIRKRWHRW 367
>gi|223717978 corticotropin releasing hormone receptor 1 isoform 3
[Homo sapiens]
Length = 375
Score = 161 bits (408), Expect = 1e-39
Identities = 104/329 (31%), Positives = 162/329 (49%), Gaps = 31/329 (9%)
Query: 130 SGRAYRHCLAQGTWQTIENATDIWQDDSECSE--NHSFKQNVDRYALLSTLQLMYTVGYS 187
S YR CLA G+W N SEC E N K V + + ++ +G+
Sbjct: 40 SDNGYRECLANGSWAARVNY-------SECQEILNEEKKSKVHYHVAV----IINYLGHC 88
Query: 188 FSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNEN 247
SL++L +A L L LR + C RN IH NL ++FILR V + + +
Sbjct: 89 ISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQ---SNV 145
Query: 248 GWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER-RLWPRYLLL 306
GW CR V +YF N+ W+ EG YLHT + T +R R W ++ +
Sbjct: 146 GW----------CRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKW-MFICI 194
Query: 307 GWAFPVLFVVPWGFARAHLENTGCW-TTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLL 365
GW P +V W + + +N CW +I +GPM+L + +NF I+++L
Sbjct: 195 GWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRIL 254
Query: 366 ISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLS 425
++KL+A + K+TLVL+PLLG+ +LF F+ + E ++++ ++ L
Sbjct: 255 MTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLF-FVNPGEDE-VSRVVFIYFNSFLE 312
Query: 426 SFHGFLVALQYGFANGEVKAELRKYWVRF 454
SF GF V++ Y F N EV++ +RK W R+
Sbjct: 313 SFQGFFVSVFYCFLNSEVRSAIRKRWHRW 341
>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
Length = 874
Score = 86.7 bits (213), Expect = 5e-17
Identities = 78/279 (27%), Positives = 133/279 (47%), Gaps = 37/279 (13%)
Query: 184 VGYSFSLISLFLALTLLLFLRKLHCTRN---YIHMNLFASFILRTLAVLVKDVVFYNSYS 240
VG S S++ L L L + RN +IH NL + AVLV V+ S+
Sbjct: 572 VGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANL-------SFAVLVAQVLLLISFR 624
Query: 241 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW 300
P +T C+ + VLLHYF + + W+LVEGL+L++++ E
Sbjct: 625 LEPG------------TTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKH 672
Query: 301 PRYLLLGWAFPVLF-VVPWGFAR-AHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIF 358
Y +GW FP+L ++ FA ++ + CW + + IW + P + + VN I
Sbjct: 673 RYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFV-APALFVIVVNIGIL 731
Query: 359 LKILKLLISKLKA--HQMCFRDYKYRL-AKSTLVLIPLLGVHEILFSFITDDQVEGFAKL 415
+ + + +IS++ A +++ ++L AK+ VL+P+LG + F + V G A +
Sbjct: 732 IAVTR-VISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWV-FGVLA---VNGCAVV 786
Query: 416 IRLFIQLTLSSFHGFLVALQYGFANGEVKAELR---KYW 451
+ ++ TL+S G + L + N EV+A + K W
Sbjct: 787 FQ-YMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVW 824
>gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens]
Length = 1474
Score = 70.5 bits (171), Expect = 4e-12
Identities = 80/294 (27%), Positives = 116/294 (39%), Gaps = 45/294 (15%)
Query: 178 LQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYN 237
L ++ VG SL+ L + ++ FLR L RN IH NL + L L LV
Sbjct: 860 LSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLV------- 912
Query: 238 SYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER 297
K ++ +C LLHYF A + WL +EG++L+ LL E
Sbjct: 913 GIDK------------TQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEY 960
Query: 298 RLWPRYLLLGWAFPVLFVVPWGFA-----RAHLENTGCWTTNGNKKIWWIIRGPMMLCVT 352
Y L G+ FP L V G A R++ CW N IW I GP+ +
Sbjct: 961 SRTKYYYLGGYCFPALVV---GIAAAIDYRSYGTEKACWLRVDNYFIWSFI-GPVSFVIV 1016
Query: 353 VNFFIFLKILKLLI---SKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEIL-FSFITDDQ 408
VN + L +I S LK + K A + L+ LLG+ FI +
Sbjct: 1017 VNLVFLMVTLHKMIRSSSVLKPDSSRLDNIK-SWALGAIALLFLLGLTWAFGLLFINKES 1075
Query: 409 VEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGC 462
V + ++ T ++F G + + + +V E K RHS C
Sbjct: 1076 V------VMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSK------CLRHSYC 1117
>gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens]
Length = 1469
Score = 70.5 bits (171), Expect = 4e-12
Identities = 80/294 (27%), Positives = 116/294 (39%), Gaps = 45/294 (15%)
Query: 178 LQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYN 237
L ++ VG SL+ L + ++ FLR L RN IH NL + L L LV
Sbjct: 855 LSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLV------- 907
Query: 238 SYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER 297
K ++ +C LLHYF A + WL +EG++L+ LL E
Sbjct: 908 GIDK------------TQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEY 955
Query: 298 RLWPRYLLLGWAFPVLFVVPWGFA-----RAHLENTGCWTTNGNKKIWWIIRGPMMLCVT 352
Y L G+ FP L V G A R++ CW N IW I GP+ +
Sbjct: 956 SRTKYYYLGGYCFPALVV---GIAAAIDYRSYGTEKACWLRVDNYFIWSFI-GPVSFVIV 1011
Query: 353 VNFFIFLKILKLLI---SKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEIL-FSFITDDQ 408
VN + L +I S LK + K A + L+ LLG+ FI +
Sbjct: 1012 VNLVFLMVTLHKMIRSSSVLKPDSSRLDNIK-SWALGAIALLFLLGLTWAFGLLFINKES 1070
Query: 409 VEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGC 462
V + ++ T ++F G + + + +V E K RHS C
Sbjct: 1071 V------VMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSK------CLRHSYC 1112
>gi|68508955 CD97 antigen isoform 3 precursor [Homo sapiens]
Length = 786
Score = 68.6 bits (166), Expect = 1e-11
Identities = 75/299 (25%), Positives = 127/299 (42%), Gaps = 30/299 (10%)
Query: 158 ECSENHSFKQNVDRYALLS-TLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMN 216
+CS SF + Y + L L+ VG + SL L L + L +R + +R IH++
Sbjct: 477 QCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLH 536
Query: 217 LFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYL 276
L + + V +F +NE G ++ CR V LLHY A +
Sbjct: 537 L-------CICLFVGSTIFLAGI----ENEGG------QVGLRCRLVAGLLHYCFLAAFC 579
Query: 277 WLLVEGLYLHTLLEPTVLPERRLWPRYL-LLGWAFPVLFVVPWG--FARAHLENTGCWTT 333
W+ +EGL L+ L+ V + L R+L L+G+ P+L V +++ + CW
Sbjct: 580 WMSLEGLELYFLV-VRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCW-L 637
Query: 334 NGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYK--YRLAKSTLVLI 391
+ + W GP+ + N IF+ + L K + K L + + +
Sbjct: 638 DFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL 697
Query: 392 PLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKY 450
LLG + FI DD+ L+ ++ L+ G + L + N +V+ E RK+
Sbjct: 698 FLLGCTWVFGLFIFDDR-----SLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKW 751
>gi|17978489 CD97 antigen isoform 2 precursor [Homo sapiens]
Length = 742
Score = 68.6 bits (166), Expect = 1e-11
Identities = 75/299 (25%), Positives = 127/299 (42%), Gaps = 30/299 (10%)
Query: 158 ECSENHSFKQNVDRYALLS-TLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMN 216
+CS SF + Y + L L+ VG + SL L L + L +R + +R IH++
Sbjct: 433 QCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLH 492
Query: 217 LFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYL 276
L + + V +F +NE G ++ CR V LLHY A +
Sbjct: 493 L-------CICLFVGSTIFLAGI----ENEGG------QVGLRCRLVAGLLHYCFLAAFC 535
Query: 277 WLLVEGLYLHTLLEPTVLPERRLWPRYL-LLGWAFPVLFVVPWG--FARAHLENTGCWTT 333
W+ +EGL L+ L+ V + L R+L L+G+ P+L V +++ + CW
Sbjct: 536 WMSLEGLELYFLV-VRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCW-L 593
Query: 334 NGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYK--YRLAKSTLVLI 391
+ + W GP+ + N IF+ + L K + K L + + +
Sbjct: 594 DFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL 653
Query: 392 PLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKY 450
LLG + FI DD+ L+ ++ L+ G + L + N +V+ E RK+
Sbjct: 654 FLLGCTWVFGLFIFDDR-----SLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKW 707
>gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
Length = 835
Score = 68.6 bits (166), Expect = 1e-11
Identities = 75/299 (25%), Positives = 127/299 (42%), Gaps = 30/299 (10%)
Query: 158 ECSENHSFKQNVDRYALLS-TLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMN 216
+CS SF + Y + L L+ VG + SL L L + L +R + +R IH++
Sbjct: 526 QCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLH 585
Query: 217 LFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYL 276
L + + V +F +NE G ++ CR V LLHY A +
Sbjct: 586 L-------CICLFVGSTIFLAGI----ENEGG------QVGLRCRLVAGLLHYCFLAAFC 628
Query: 277 WLLVEGLYLHTLLEPTVLPERRLWPRYL-LLGWAFPVLFVVPWG--FARAHLENTGCWTT 333
W+ +EGL L+ L+ V + L R+L L+G+ P+L V +++ + CW
Sbjct: 629 WMSLEGLELYFLV-VRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCW-L 686
Query: 334 NGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYK--YRLAKSTLVLI 391
+ + W GP+ + N IF+ + L K + K L + + +
Sbjct: 687 DFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL 746
Query: 392 PLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKY 450
LLG + FI DD+ L+ ++ L+ G + L + N +V+ E RK+
Sbjct: 747 FLLGCTWVFGLFIFDDR-----SLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKW 800
>gi|148806925 EGF, latrophilin and seven transmembrane domain
containing 1 [Homo sapiens]
Length = 690
Score = 67.4 bits (163), Expect = 3e-11
Identities = 59/220 (26%), Positives = 93/220 (42%), Gaps = 32/220 (14%)
Query: 184 VGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRP 243
+G SLI L + + F ++ TR IH NL S L L LV N+ + +
Sbjct: 433 LGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVG----INTNTNK- 487
Query: 244 DNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRY 303
C + LLHYF A + W+ +EG++L+ ++ + + L +
Sbjct: 488 --------------LFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNF 533
Query: 304 LLLGWAFPVLFVVPWGFA-----RAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIF 358
+ G+ P + V GF+ R + CW + N IW I GP L + VN F
Sbjct: 534 YIFGYLSPAVVV---GFSAALGYRYYGTTKVCWLSTENNFIWSFI-GPACLIILVNLLAF 589
Query: 359 LKILKLLI---SKLKAHQMCFRDYKYRLAKSTLVLIPLLG 395
I+ + + LK CF + + A+ L L+ LLG
Sbjct: 590 GVIIYKVFRHTAGLKPEVSCFENIR-SCARGALALLFLLG 628
>gi|163792198 latrophilin 3 precursor [Homo sapiens]
Length = 1469
Score = 59.3 bits (142), Expect = 9e-09
Identities = 50/209 (23%), Positives = 87/209 (41%), Gaps = 25/209 (11%)
Query: 178 LQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYN 237
L ++ VG SL+ L + + F R L RN IH NL +++ V +++F
Sbjct: 877 LDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNL-------CISLFVAELLFLI 929
Query: 238 SYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER 297
++ ++ +C LLH+F A + W+ +EG+ L+ +L E
Sbjct: 930 GINR------------TDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEH 977
Query: 298 RLWPRYLLLGWAFPVLFVVPWGFA--RAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVN- 354
+ L+G+ P L V R++ + CW IW I GP L + +N
Sbjct: 978 SRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFI-GPATLIIMLNV 1036
Query: 355 FFIFLKILKLL--ISKLKAHQMCFRDYKY 381
F+ + + K+ + LK C + Y
Sbjct: 1037 IFLGIALYKMFHHTAILKPESGCLDNINY 1065
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 58.2 bits (139), Expect = 2e-08
Identities = 66/301 (21%), Positives = 118/301 (39%), Gaps = 41/301 (13%)
Query: 158 ECSENHSFKQNVD----RYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYI 213
+CS SF +D + L+++ S SL +L +A LL +R L + I
Sbjct: 2444 QCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSI 2503
Query: 214 HMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGA 273
H +L +A+ + +VF ++ EN ++ C V +LLHY +
Sbjct: 2504 HKHL-------AVALFLSQLVFVIGINQ---TENPFL---------CTVVAILLHYIYMS 2544
Query: 274 NYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLF------VVPWGFARAHLEN 327
+ W LVE L+++ +L + Y ++GW P + + P G+
Sbjct: 2545 TFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDF-- 2602
Query: 328 TGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKST 387
CW + + I W GP+ + +N +L +S + H + L ++
Sbjct: 2603 --CWLSLQDTLI-WSFAGPIGAVIIIN--TVTSVLSAKVSCQRKHHYYGKKGIVSLLRTA 2657
Query: 388 LVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAEL 447
+L+ L+ +L + F L +F S G V L + N EV+ L
Sbjct: 2658 FLLLLLISATWLLGLLAVNRDALSFHYLFAIF-----SGLQGPFVLLFHCVLNQEVRKHL 2712
Query: 448 R 448
+
Sbjct: 2713 K 2713
>gi|23397681 egf-like module containing, mucin-like, hormone
receptor-like sequence 2 isoform a [Homo sapiens]
Length = 823
Score = 58.2 bits (139), Expect = 2e-08
Identities = 102/438 (23%), Positives = 163/438 (37%), Gaps = 76/438 (17%)
Query: 49 GRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRD----LLKEPSGIFCNGTFDQYV 104
G P ++V LVSI + G LL E KQ L + LL++ S I + ++
Sbjct: 395 GDPGPSVVGLVSIPGM-GKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFL 453
Query: 105 CWPH----SSPGNVSVPCPSYLP-------WWSEESSGRAYRHCLAQGTWQTIENATDIW 153
SSP + S +P +W +G C G W T +T
Sbjct: 454 SNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNG-----C---GHWATTGCSTIGT 505
Query: 154 QDDS---ECSENHSFKQNVDRYALLS---TLQLMYTVGYSFSLISLFLALTLLLFLRKLH 207
+D S C+ SF + Y + L ++ +G S SL+ L LA L + +
Sbjct: 506 RDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQ 565
Query: 208 CTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLL 267
T +H+ L L L LV ++ G C + L
Sbjct: 566 NTSTSLHLQLSLCLFLAHLLFLVAI------------DQTGH-------KVLCSIIAGTL 606
Query: 268 HYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLL-----LGWAFPVLFVVPWGFAR 322
HY A W+L+E LYL + R++ +G+ P + V +R
Sbjct: 607 HYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASR 666
Query: 323 AHLENT--GCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK---ILKLLISKLKAHQMCFR 377
HL T CW IW + GP+ +VN +FL ILK +S L + R
Sbjct: 667 PHLYGTPSRCWLQPEKGFIWGFL-GPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLR 725
Query: 378 DYKYRLAKSTLVLIPL-----LGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLV 432
+ + K+T L L LG+ ++ G A + ++ ++S G +
Sbjct: 726 NTRMLAFKATAQLFILGCTWCLGILQV-----------GPAARVMAYLFTIINSLQGVFI 774
Query: 433 ALQYGFANGEVKAELRKY 450
L Y + +V+ + K+
Sbjct: 775 FLVYCLLSQQVREQYGKW 792
>gi|23397687 egf-like module containing, mucin-like, hormone
receptor-like sequence 2 isoform d [Homo sapiens]
Length = 681
Score = 58.2 bits (139), Expect = 2e-08
Identities = 102/438 (23%), Positives = 163/438 (37%), Gaps = 76/438 (17%)
Query: 49 GRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRD----LLKEPSGIFCNGTFDQYV 104
G P ++V LVSI + G LL E KQ L + LL++ S I + ++
Sbjct: 253 GDPGPSVVGLVSIPGM-GKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFL 311
Query: 105 CWPH----SSPGNVSVPCPSYLP-------WWSEESSGRAYRHCLAQGTWQTIENATDIW 153
SSP + S +P +W +G C G W T +T
Sbjct: 312 SNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNG-----C---GHWATTGCSTIGT 363
Query: 154 QDDS---ECSENHSFKQNVDRYALLS---TLQLMYTVGYSFSLISLFLALTLLLFLRKLH 207
+D S C+ SF + Y + L ++ +G S SL+ L LA L + +
Sbjct: 364 RDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQ 423
Query: 208 CTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLL 267
T +H+ L L L LV ++ G C + L
Sbjct: 424 NTSTSLHLQLSLCLFLAHLLFLVAI------------DQTGH-------KVLCSIIAGTL 464
Query: 268 HYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLL-----LGWAFPVLFVVPWGFAR 322
HY A W+L+E LYL + R++ +G+ P + V +R
Sbjct: 465 HYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASR 524
Query: 323 AHLENT--GCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK---ILKLLISKLKAHQMCFR 377
HL T CW IW + GP+ +VN +FL ILK +S L + R
Sbjct: 525 PHLYGTPSRCWLQPEKGFIWGFL-GPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLR 583
Query: 378 DYKYRLAKSTLVLIPL-----LGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLV 432
+ + K+T L L LG+ ++ G A + ++ ++S G +
Sbjct: 584 NTRMLAFKATAQLFILGCTWCLGILQV-----------GPAARVMAYLFTIINSLQGVFI 632
Query: 433 ALQYGFANGEVKAELRKY 450
L Y + +V+ + K+
Sbjct: 633 FLVYCLLSQQVREQYGKW 650
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.452
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,354,914
Number of Sequences: 37866
Number of extensions: 1056282
Number of successful extensions: 3318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 3132
Number of HSP's gapped (non-prelim): 113
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.