Search of human proteins with 109134347

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109134347 NY-REN-58 antigen [Homo sapiens]
         (701 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109134347 NY-REN-58 antigen [Homo sapiens]                        1347   0.0  
gi|109134355 NY-REN-58 antigen [Homo sapiens]                        1347   0.0  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   125   1e-28
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   123   5e-28
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   123   7e-28
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   118   2e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   118   2e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   118   2e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   118   2e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   116   8e-26
gi|71061468 centromere protein E [Homo sapiens]                       116   8e-26
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   115   2e-25
gi|55770834 centromere protein F [Homo sapiens]                       114   2e-25
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   114   3e-25
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                 114   4e-25
gi|41872583 Rho-associated, coiled-coil containing protein kinas...   113   5e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            112   1e-24
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   112   2e-24
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   112   2e-24
gi|31982906 cingulin-like 1 [Homo sapiens]                            112   2e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   111   3e-24
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   111   3e-24
gi|148746195 trichohyalin [Homo sapiens]                              110   6e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   108   1e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       108   1e-23
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       108   1e-23
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        108   1e-23
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        108   1e-23
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        108   1e-23
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        108   1e-23

>gi|109134347 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 701/701 (100%), Positives = 701/701 (100%)

Query: 1   MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ 60
           MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ
Sbjct: 1   MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ 60

Query: 61  NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA 120
           NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA
Sbjct: 61  NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA 120

Query: 121 QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
           QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY
Sbjct: 121 QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180

Query: 181 ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
           ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN
Sbjct: 181 ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240

Query: 241 SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK 300
           SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK
Sbjct: 241 SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK 300

Query: 301 AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA 360
           AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA
Sbjct: 301 AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA 360

Query: 361 AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ 420
           AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ
Sbjct: 361 AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ 420

Query: 421 SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
           SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI
Sbjct: 421 SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480

Query: 481 QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
           QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH
Sbjct: 481 QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540

Query: 541 KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600
           KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ
Sbjct: 541 KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600

Query: 601 VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL 660
           VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL
Sbjct: 601 VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL 660

Query: 661 PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE 701
           PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE
Sbjct: 661 PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE 701


>gi|109134355 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 701/701 (100%), Positives = 701/701 (100%)

Query: 1   MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ 60
           MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ
Sbjct: 1   MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQ 60

Query: 61  NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA 120
           NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA
Sbjct: 61  NEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRA 120

Query: 121 QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
           QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY
Sbjct: 121 QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180

Query: 181 ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
           ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN
Sbjct: 181 ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240

Query: 241 SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK 300
           SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK
Sbjct: 241 SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK 300

Query: 301 AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA 360
           AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA
Sbjct: 301 AEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKA 360

Query: 361 AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ 420
           AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ
Sbjct: 361 AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQ 420

Query: 421 SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
           SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI
Sbjct: 421 SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480

Query: 481 QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
           QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH
Sbjct: 481 QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540

Query: 541 KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600
           KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ
Sbjct: 541 KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600

Query: 601 VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL 660
           VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL
Sbjct: 601 VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMEL 660

Query: 661 PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE 701
           PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE
Sbjct: 661 PFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE 701


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  125 bits (314), Expect = 1e-28
 Identities = 163/755 (21%), Positives = 342/755 (45%), Gaps = 121/755 (16%)

Query: 52   LKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE------ELRGELVEKTKDLEEM 105
            +K + T+++ E  +++ + + L  EK    E+LQ   E      E+R  L  K ++LEE+
Sbjct: 864  VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
               + +  + E  R QI Q  +  M+   ++L+E++++      KL+ E    +++ +  
Sbjct: 924  LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983

Query: 166  KEEYARILDEG------KIKYESEIA----RLEEDKEELRN--------QLLNVDLTKDS 207
            +EE   + D+       K   E  IA    +L E++E+ +N        +++  DL +  
Sbjct: 984  EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043

Query: 208  KRVEQLAREKVYLCQKLKG-----------LEAEVAELKAEKENSEAQVENA-------- 248
            K+ E+  +E     +KL G           L+A++ ELK +    E +++ A        
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103

Query: 249  --QRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH------- 299
              +   ++ + E+QA +  L+ + +S      + EK+ +  SE+   L  +L        
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163

Query: 300  -------KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSEL-------ERERNKIQ 345
                   K E+E+  L   ++E   +++ +I D++   A A  EL       +R +  ++
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223

Query: 346  SELDGLQSDNEIL----------KAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQ 395
                GL++DN+ L          KA  EH +  L  + +EL  KV     EG +  V L 
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV----SEGDRLRVELA 1279

Query: 396  DEKLELENRLADLEKMKVEHD---VWRQSEKDQYEEKLRASQ-MAEEITRKEL---QSVR 448
            ++  +L+N L ++  +  E +   +    +    E +L+ +Q + +E TR++L     +R
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339

Query: 449  LKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQ 508
               +++    E  E+E+    +L++Q+ +LQ Q+    +  +D L + + L+E  ++L +
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 509  ECRNFRSQAEKAQL---EAEKTLEEKQIQW------LEEKHKLHERITDREEKYNQ--AK 557
            +      + E+  L   + EKT    Q +       L+ + ++   +  +++K++Q  A+
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459

Query: 558  EKLQRAAIAQKKRKS-----LHENKLKRLQEKVEVLEAKKEELETENQ--------VLNR 604
            EK   A  A+++ ++       E K   L   +E     KEE E +N+        +++ 
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519

Query: 605  QNVPFEDYTRLQKRLKDIQRRHNEFRSLI--LVPNMPPTASINPVSFQSSAMVPSMELPF 662
            ++   ++   L+K  + ++++  E R+ +  L   +  T        +    + +M+  F
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT---EDAKLRLEVNMQAMKAQF 1576

Query: 663  PPHMQ--EEQHQRELSLLRKRLEELET---TQRKQ 692
               +Q  +EQ++ +  LL K++ ELE     +RKQ
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611



 Score =  108 bits (271), Expect = 1e-23
 Identities = 166/787 (21%), Positives = 336/787 (42%), Gaps = 154/787 (19%)

Query: 32   QKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQ------ 85
            +++  +E+ R E  KA  + L  E T LQ++  +LQ ++  L  +   ++E+LQ      
Sbjct: 1041 ERLKKEEKTRQELEKAK-RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099

Query: 86   -----------LLLEELRGELVEKTKDLEEMKLQILTPQK--------LELLRAQI---- 122
                        ++ EL+ ++ E  +D E  K      +K        LE L+ ++    
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159

Query: 123  -----QQELETPMRERF----RNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI- 172
                 QQEL T   +      + L+EE + + A    +R  H     E   Q E+  R  
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219

Query: 173  -----------LDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLC 221
                        D  ++  E ++ +  + + E + + L+  + +   +V +  R +V L 
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279

Query: 222  QKLKGLEAEVAEL-----KAEKE---------NSEAQVENAQRI---QVRQLAEMQATVR 264
            +K   L+ E+  +     +AEK+         + E+Q+++ Q +   + RQ   + + +R
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339

Query: 265  SLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             LE EK S   + E  E+  ++  +Q   L ++L   +++++     ++ L+ + K  + 
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 325  DIKL------ETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
            D +       E A A  +LE+ +N++Q ELD L  D +  +    +     +EK ++   
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN-----LEKKQKKFD 1454

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKV----EHDVWRQSEKDQYEEKLRASQ 434
            ++  A+E+        + ++ E E R  + + + +    E  +  + E ++  ++LRA  
Sbjct: 1455 QL-LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD- 1512

Query: 435  MAEEITRK--------ELQSVRLKLQQQI----VTIENAEKEKNENSDLKQQISSLQIQV 482
            M + ++ K        EL+  +  L+QQ+      +E  E E     D K +   L++ +
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR---LEVNM 1569

Query: 483  TSL-AQSENDLLNSNQ-------MLKEMVERLKQECRNFRSQ------------------ 516
             ++ AQ E DL   ++       +L + V  L+ E  + R Q                  
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629

Query: 517  ------AEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKR 570
                  A KA+ E  K L + Q Q  + + +L E    R+E + Q+KE       ++KK 
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE-------SEKKL 1682

Query: 571  KSLHENKLKRLQEKVEVLEAKKEELETENQVL--------NRQNVPFEDYTRLQKRLKDI 622
            KSL E ++ +LQE++   E  +   E E   L        + ++   ++  RL+ R+  +
Sbjct: 1683 KSL-EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 623  QRRHNEFRSLILVPN---MPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLR 679
            +    E +S + + N      T  ++ ++ + +A   + +       Q E+  +E   L+
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE---LK 1798

Query: 680  KRLEELE 686
             +L+ELE
Sbjct: 1799 AKLQELE 1805



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 116/530 (21%), Positives = 235/530 (44%), Gaps = 68/530 (12%)

Query: 138  DEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLE--EDKEELR 195
            +EE++       K++ + T ++ E E  + ++ ++L+E  I  E   A  E   + EE+R
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910

Query: 196  NQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE-------LKAEKENSEAQVENA 248
                            +LA +K  L + L  LE+ V E       L+ EK+  +A +++ 
Sbjct: 911  ---------------ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955

Query: 249  QRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTL 308
            +     QL E +   + L+ EK +A  + +++E+E+    +QN+  I +    E  I   
Sbjct: 956  E----EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011

Query: 309  SSKVKE--------LKHSNKLEITDIKLE-----TARAKSELERERNKIQSELDGLQSDN 355
            SS++ E         K  NK E+    LE       + + ELE+ + K+  E   LQ   
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 356  EILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQK---LVVLQDEKLELENRLADLEKMK 412
              L+A ++  K+ L +K+ EL   +    +E   K   L V+++ + ++     D E  K
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 413  VEHDVWRQSEKDQYEEKLRASQMAEEI--TRKELQSVRLKLQQQIVTIENAEKEKNENSD 470
               +   + ++D  EE        E+   T    Q +R K +Q++  ++ A +E+ +N +
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAE-KTLE 529
               QI  ++ +  +  +  ++ L   +  K  +E+ KQ       + +  +L  E K L+
Sbjct: 1192 --AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-----ETDNKELACEVKVLQ 1244

Query: 530  EKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            + + +   ++ KL  ++ +   K ++      R  +A+K  K   +N+L  +   +E  E
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDR--LRVELAEKASKL--QNELDNVSTLLEEAE 1300

Query: 590  AK-----KEELETENQVLNRQNVPFEDYTR----LQKRLKDIQRRHNEFR 630
             K     K+    E+Q+ + Q +  ++ TR    L  R++ ++   N  +
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQEL-LQEETRQKLNLSSRIRQLEEEKNSLQ 1349



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 68/301 (22%), Positives = 133/301 (44%), Gaps = 37/301 (12%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
            + Q  + D +   E  +A+   + A+    + +   L+ E+  L  E+    E+ +   E
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL-QEELASSERARRHAE 1707

Query: 90   ELRGELVEKTKDLEEMKLQILTPQK-LELLRAQIQQELETP------MRERFRNLDEEVE 142
            + R EL ++  +    K  +L  ++ LE   AQ+++ELE        + +RFR    +V+
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767

Query: 143  KYRAVYNKLR---YEHTFLKSEFEHQKEEYARILDE----GKIKYESEIARLEEDKEELR 195
               A     R    +    + + E Q +E    L E     K K+++ I+ LE    +L 
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827

Query: 196  NQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQ 255
             QL            EQ A+E+    + ++  E ++ E+  + E+     +  +    + 
Sbjct: 1828 EQL------------EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKA 1875

Query: 256  LAEMQATVRSL-EAEKQS--ANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKV 312
             A M+   R L EAE+++  AN    +L++EL  ++E N  L        RE++TL +++
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL-------SREVSTLKNRL 1928

Query: 313  K 313
            +
Sbjct: 1929 R 1929


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  123 bits (309), Expect = 5e-28
 Identities = 143/633 (22%), Positives = 282/633 (44%), Gaps = 92/633 (14%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKHLFN-EKQTQQEKLQL--LLEELRGELVEKTKDLEEMK 106
            Q L  +   L+NE V+ +  L++  N  K   +EK QL   +E LR     + K LE+  
Sbjct: 501  QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN 560

Query: 107  LQILTPQKLELLRAQIQQELETPMRERFRN-LDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              +         R+QI  E      E+    L E +++  +  +K+ +E   +K E EH 
Sbjct: 561  EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLK 225
            KE+  R  +      E+E+  LE++ E L+ ++ N+ +T   +++E L +E   L ++ +
Sbjct: 621  KEKGERAEE-----LENELHHLEKENELLQKKITNLKIT--CEKIEALEQENSELERENR 673

Query: 226  GLEAEVAELK--------AEKENSEAQVENAQ--------RIQVRQLAEMQATVRSLEAE 269
             L+  +   K         EKENS+   EN +        +    ++A++Q   + LE+E
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733

Query: 270  K------------------------QSANLRAERLEKELQSSSEQNTFLINKLHKAEREI 305
            K                        Q  ++  +RL+K L++S+++   L ++L   E E 
Sbjct: 734  KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793

Query: 306  NTLSSKVKELKHSNK----LEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAA 361
             TL   ++ELK S+K    LE  +  LE  +  S+LE+++ +++ E   L+   EI    
Sbjct: 794  QTLQKNLEELKISSKRLEQLEKENKSLE--QETSQLEKDKKQLEKENKRLRQQAEIKDTT 851

Query: 362  VEHHKVLL--VEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWR 419
            +E + V +  +EK+ + + K     +E   +L  L+ E  EL      +++  ++     
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL------VKRATIDIKTLV 905

Query: 420  QSEKDQYEEKLRASQMAEEITR--KELQSVRLKLQQQIVTIENAEK-----EKNENSDLK 472
               +D   EKL+  QM  ++ +   EL+ + L  ++ +   ++ +      E    S LK
Sbjct: 906  TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK 965

Query: 473  QQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRS-QAEKAQLEAEKTLEEK 531
            + +   + ++ +L     +  N NQ L++ ++ +K+     +  Q E+  +++   +  +
Sbjct: 966  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025

Query: 532  QIQWLEEKH-------KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLK----- 579
              +W  E         K+ +R+ +  E+ N   +  ++A   Q K+     N L+     
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084

Query: 580  ------RLQEKVEVLEAKKEELETENQVLNRQN 606
                   LQE+   L+ +  +L+ EN  LN Q+
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117



 Score =  116 bits (290), Expect = 8e-26
 Identities = 144/609 (23%), Positives = 282/609 (46%), Gaps = 49/609 (8%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQI 109
            ++L+ E+++L  E+++L+  ++ L      +  +LQL  +EL  E  +  K LE +K   
Sbjct: 690  ESLEKENSQLDEENLELRRNVESL-KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 110  LTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEY 169
               ++LE+    +  E +  +++   N ++++++  +    L  E+  L+   E  K   
Sbjct: 749  KKTERLEVSYQGLDIENQR-LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807

Query: 170  ARI--LDEGKIKYESEIARLEEDKEELRNQ---------LLNVDLTKDSKRVEQLAREKV 218
             R+  L++     E E ++LE+DK++L  +         + +  L +++ ++  L +E  
Sbjct: 808  KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 219  YLCQKLKGLEAEVAELKA-EKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRA 277
             L +++   +     LK  EKEN E  V+ A  I ++ L  ++  + S + + Q  N   
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKEL-VKRAT-IDIKTLVTLREDLVSEKLKTQQMNNDL 925

Query: 278  ERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKE-LKHSNKLEITDIKLETARAKSE 336
            E+L  EL+        L++     +     L SK++  LK S  LEI + K+    A+ E
Sbjct: 926  EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS--LEIKEEKIAALEARLE 983

Query: 337  LERERNK-IQSELDGLQSDNEILKAAVEHHKVLLVEKDRELI---RKVQAAKEEGYQKLV 392
                 N+ ++ EL  ++ + E LK   +  +  +V+    +     K +   +E  ++L+
Sbjct: 984  ESTNYNQQLRQELKTVKKNYEALKQRQDEER--MVQSSPPISGEDNKWERESQETTRELL 1041

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEE-KLRASQMAEEITRKELQSVRLKL 451
             ++D  +E+E   A L+  K       Q+ K Q ++ + + + +  +I   + Q+V L+ 
Sbjct: 1042 KVKDRLIEVERNNATLQAEK-------QALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1094

Query: 452  QQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECR 511
            Q   +  +NA K + ENS L  Q +SL  Q   L   ++ L N N+ + +  E LK    
Sbjct: 1095 QNTTLQTQNA-KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153

Query: 512  NFRSQAEKAQLEAEKTLEE-----KQIQWLEEKHK-LHERITDREEKYNQ-AKEKLQRAA 564
            +     EK +L  E+   E      +   L+  HK L     D E++YNQ  K+K Q   
Sbjct: 1154 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1213

Query: 565  IAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQR 624
            +  +K   + + K+    +  E + A+ ++L  EN  LN        Y++L K  + +Q 
Sbjct: 1214 L--EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN------HTYSQLLKETEVLQT 1265

Query: 625  RHNEFRSLI 633
             H   +SL+
Sbjct: 1266 DHKNLKSLL 1274



 Score =  115 bits (288), Expect = 1e-25
 Identities = 142/627 (22%), Positives = 298/627 (47%), Gaps = 84/627 (13%)

Query: 64  VKLQNELKHLFNEKQTQQEKLQLL---LEELRGELVEKTKDLEEMKLQI--LTPQKLELL 118
           +K     +HL  E    + K++ L   LEE   +L++  ++LE+M++++  L  + + LL
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299

Query: 119 ----RAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILD 174
                A++ ++    +RE+   +D ++E   + Y +  ++  F K+  E  KE+   +L+
Sbjct: 300 SDARSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE 358

Query: 175 ---------EGKIKYESEIARLEEDKEELRNQLLNVDLTK--DSKRVEQLAREKVYL--C 221
                    EG      ++  LE++  +L+ +L ++++ +  D K++E+L  E + L   
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418

Query: 222 QKLKGLEA-----EVAELKAEKENSEA------------------QVENAQRIQVRQLAE 258
           QK    E+     E+ ++    E SEA                  ++E   +   + + E
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478

Query: 259 MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL-KH 317
           ++ TV S+E        +  ++EKE Q  S++   L N++ + ++ +    +  K+L K 
Sbjct: 479 LRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534

Query: 318 SNKLEITDIKLETARAKSE-----LERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEK 372
             +LE T   +ET R  SE     LE+E   +   +  L+  ++I   A    +V  +EK
Sbjct: 535 KAQLEKT---IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA----RVKDIEK 587

Query: 373 DRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRA 432
           + +++ +   + +E   KL  ++ EK ++        K ++EH   +    ++ E +L  
Sbjct: 588 ENKILHE---SIKETSSKLSKIEFEKRQI--------KKELEHYKEKGERAEELENELHH 636

Query: 433 SQMAEEITRKELQSVRLKLQQ-QIVTIENAEKEKNENSDLKQQISS---LQIQVTSLAQS 488
            +   E+ +K++ ++++  ++ + +  EN+E E+ EN  LK+ + S   L  Q+ SL + 
Sbjct: 637 LEKENELLQKKITNLKITCEKIEALEQENSELER-ENRKLKKTLDSFKNLTFQLESLEKE 695

Query: 489 ENDLLNSNQMLKEMVERLK-QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERIT 547
            + L   N  L+  VE LK    +  + Q E  +LE+EK   +K ++ L+   K  ER+ 
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755

Query: 548 DREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN---QVLNR 604
              +  +   ++LQ+      K+    E++L+ L+ + + L+   EEL+  +   + L +
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815

Query: 605 QNVPFEDYT-RLQKRLKDIQRRHNEFR 630
           +N   E  T +L+K  K +++ +   R
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLR 842



 Score =  113 bits (282), Expect = 7e-25
 Identities = 150/667 (22%), Positives = 299/667 (44%), Gaps = 86/667 (12%)

Query: 67   QNELKHLFNEK--------QTQQEKLQLLLEELRGEL--VE--KTKDLEEMKLQILTPQK 114
            Q  L H  NE         + + + L   +EELR  +  VE   +K L+  K      +K
Sbjct: 447  QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506

Query: 115  LELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKL--------RYEHTFLKSEFEHQK 166
            +E+L  +I QE ++   +  +NL +++ K +A   K           +   L+ E EH  
Sbjct: 507  VEILENEIVQEKQS--LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564

Query: 167  EEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKG 226
            +  + +    +I  E+ +  +E++     N++L+  + + S ++ ++  EK  + ++L+ 
Sbjct: 565  QTVSSLRQRSQISAEARVKDIEKE-----NKILHESIKETSSKLSKIEFEKRQIKKELEH 619

Query: 227  LEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQS 286
             + E  E   E EN    +E    +  +++  ++ T   +EA +Q  N   ER  ++L+ 
Sbjct: 620  YK-EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-NSELERENRKLKK 677

Query: 287  SSEQNTFLINKLHKAEREINTLSSKVKELKHS-NKLEITDIKLETARAKSELERERNKIQ 345
            + +    L  +L   E+E + L  +  EL+ +   L+   +K+      ++L+ E  +++
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM------AQLQLENKELE 731

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELI--RKVQAAKEEGYQKLVVLQDE--KLEL 401
            SE + L+   E+LKA+ +  + L V      I  +++Q   E   +K+  L+ E   LE+
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 402  ENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIE 459
            EN+    +LE++K+      Q EK+    +   SQ+ ++  +K+L+    +L+QQ    +
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--KKQLEKENKRLRQQAEIKD 849

Query: 460  NAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK 519
               +E N             +++ +L +    L     + KE   RLK+  +  +   ++
Sbjct: 850  TTLEENN-------------VKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896

Query: 520  AQLEAEKTLEEKQIQWLEEKHKLH------ERITDREEKYNQAKEKL--------QRAAI 565
            A ++  KTL   +   + EK K        E++T   EK    KE+L         R  +
Sbjct: 897  ATIDI-KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL 955

Query: 566  AQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRR 625
             + K +S  +  L+  +EK+  LEA+ EE    NQ L       ++   ++K  + +++R
Sbjct: 956  LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR------QELKTVKKNYEALKQR 1009

Query: 626  HNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQH-----QRELSLLRK 680
             +E R   +V + PP +  +    + S       L     + E +      Q E   L+ 
Sbjct: 1010 QDEER---MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066

Query: 681  RLEELET 687
            +L++LET
Sbjct: 1067 QLKQLET 1073



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 152/668 (22%), Positives = 288/668 (43%), Gaps = 114/668 (17%)

Query: 41   RCEHHKANYQTLKAEHTRLQ----NEHVKLQ---NELKHLFNEKQTQQEKL-QLLLEELR 92
            + E  + +YQ L  E+ RLQ    N + K+Q   +EL+ L  E QT Q+ L +L +   R
Sbjct: 750  KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809

Query: 93   GELVEK-TKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKL 151
             E +EK  K LE+   Q      LE  + Q+++E    +R++    D  +E+       L
Sbjct: 810  LEQLEKENKSLEQETSQ------LEKDKKQLEKE-NKRLRQQAEIKDTTLEENNVKIGNL 862

Query: 152  RYEHTFLKSEFEHQKEEYARILDEGKIKYE---------SEIARLEED--KEELRNQLLN 200
              E+  L  E    KE   R+ +  K   E           +  L ED   E+L+ Q +N
Sbjct: 863  EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922

Query: 201  VDLTKDSKRVEQLAREKVYLC--------------QKLKGLEAEVAELKAEKENS-EAQV 245
             DL K +  +E++   K  L                KL+    +  E+K EK  + EA++
Sbjct: 923  NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982

Query: 246  ENAQRIQVRQLAEMQATVRSLEAEKQ----------SANLRAE--RLEKELQSSSEQNTF 293
            E +     +   E++   ++ EA KQ          S  +  E  + E+E Q ++ +   
Sbjct: 983  EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1042

Query: 294  LINKLHKAEREINTLSSKVKELK--------HSNKLEITDIKLETARAKSELERERNKIQ 345
            + ++L + ER   TL ++ + LK         +N L+   + L+  R    L+ +   +Q
Sbjct: 1043 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ--RQTVSLQEQNTTLQ 1100

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRL 405
            ++   LQ +N  L +        L+ ++ +L+ +  + + E    +   +D K   ++ +
Sbjct: 1101 TQNAKLQVENSTLNS----QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156

Query: 406  ADLEKMKVEHDVWRQSEKDQYEE------KLRASQMAEEITRKELQ---SVRLKLQQQIV 456
             D EK+++ H    + +  +YE        L+++    E+  ++L+   +  LK + Q+ 
Sbjct: 1157 KDHEKLELLH----ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLE 1212

Query: 457  TIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNS--NQMLKEMVERLKQECRNFR 514
             +E   K + E   L+ +              END LN   +Q+LKE  E L+ + +N +
Sbjct: 1213 DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE-TEVLQTDHKNLK 1271

Query: 515  SQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLH 574
            S    ++LE                       T  E ++++ KE+ Q+  I   K  +  
Sbjct: 1272 SLLNNSKLEQ----------------------TRLEAEFSKLKEQYQQLDITSTKLNNQC 1309

Query: 575  E--NKLK-RLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKR-----LKDIQRRH 626
            E  ++LK  L+E+   L  + + L  +N+ L  QN+  +D   +++R     L +++R+ 
Sbjct: 1310 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1369

Query: 627  NEFRSLIL 634
             +    I+
Sbjct: 1370 EKLEEKIM 1377



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 94/440 (21%), Positives = 187/440 (42%), Gaps = 81/440 (18%)

Query: 266 LEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITD 325
           L  E   A  +  RL +EL+  +EQ       L   ++E+  +  ++K L+  N   ++D
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 326 IK--------LETARAKS----ELERERNKIQSELDGLQSDNEILKAAVEHHKVLL---- 369
            +        L+  R K+    +LE E ++ +  L  ++     ++   E ++VLL    
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 370 -----VEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKD 424
                +E  R    K+   ++E  Q    L D ++E +     +E++  E+     ++K 
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421

Query: 425 QYEEKLRASQMAEEITR----KELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
             +E L      E+I+R     E     L  +   +T     K + EN  L + +  L+ 
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481

Query: 481 QVTSLAQSENDLL---NSNQMLKEMVERLK----------QECRNFRSQAEKAQLEAEKT 527
            V S+  + + +L     NQ L + VE L+          Q C+N      K + + EKT
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541

Query: 528 LE------EKQIQWLEEKHK-LHERITDREEKYNQAKEKLQRAAIAQKKRKSLHE----- 575
           +E      E+QI+ LE++++ L++ ++   ++   + E   R    +K+ K LHE     
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE--ARVKDIEKENKILHESIKET 599

Query: 576 -NKLKRLQ-----------------EKVEVLEAKKEELETENQVLNRQ----NVPFEDYT 613
            +KL +++                 E+ E LE +   LE EN++L ++     +  E   
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIE 659

Query: 614 RLQKRLKDIQRRHNEFRSLI 633
            L++   +++R + + +  +
Sbjct: 660 ALEQENSELERENRKLKKTL 679



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 40/278 (14%)

Query: 430 LRASQMAEEITRKELQSVRLKLQQQI-------VTIENAEKEKNENSDLKQQISSLQIQV 482
           +  + M++E     L+++ L L++ I        TI    +E++    L    SS Q   
Sbjct: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPC 235

Query: 483 TSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ---LEAEKTLEEKQIQWLEEK 539
            S      +   S Q L   +   K + R  R + E+     L+ ++ LE+ +I+    +
Sbjct: 236 GSPGMKRTE---SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ 292

Query: 540 HKLHERITDREEK--YNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELET 597
            +    ++D      Y    + L+  A+   K +S      +RL + +E  +A+ EEL+ 
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHD-IEFYKARVEELKE 351

Query: 598 ENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPS 657
           +NQVL       E  T L+ +L+  + R ++   L               + Q  A +  
Sbjct: 352 DNQVL------LETKTMLEDQLEGTRARSDKLHEL------------EKENLQLKAKLHD 393

Query: 658 MELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEE 695
           ME      M+ +  ++++  L +    LE  Q++ ++E
Sbjct: 394 ME------MERDMDRKKIEELMEENMTLEMAQKQSMDE 425



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 39/182 (21%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 26   GSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEK---QTQQE 82
            G   + +KML  E+ +      N++T+ AE+ +L  E+ +L +    L  E    QT  +
Sbjct: 1209 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268

Query: 83   KLQLLLEELRGELVEKTKDLEEMKLQI----LTPQKLELLRAQIQQELETPMRERFRNLD 138
             L+ LL   + E      +  ++K Q     +T  KL   + ++  +L+  + E  R+L 
Sbjct: 1269 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHLL 1327

Query: 139  EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL 198
            ++++        L  ++   K  F  ++ +Y   L+E           L   KE+L  ++
Sbjct: 1328 DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-----------LRRQKEKLEEKI 1376

Query: 199  LN 200
            ++
Sbjct: 1377 MD 1378


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  123 bits (308), Expect = 7e-28
 Identities = 143/634 (22%), Positives = 282/634 (44%), Gaps = 93/634 (14%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKHLFN-EKQTQQEKLQL--LLEELRGELVEKTKDLEEMK 106
            Q L  +   L+NE V+ +  L++  N  K   +EK QL   +E LR     + K LE+  
Sbjct: 501  QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN 560

Query: 107  LQILTPQKLELLRAQIQQELETPMRERFRN-LDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              +         R+QI  E      E+    L E +++  +  +K+ +E   +K E EH 
Sbjct: 561  EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLK 225
            KE+  R  +      E+E+  LE++ E L+ ++ N+ +T   +++E L +E   L ++ +
Sbjct: 621  KEKGERAEE-----LENELHHLEKENELLQKKITNLKIT--CEKIEALEQENSELERENR 673

Query: 226  GLEAEVAELK--------AEKENSEAQVENAQ--------RIQVRQLAEMQATVRSLEAE 269
             L+  +   K         EKENS+   EN +        +    ++A++Q   + LE+E
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733

Query: 270  K------------------------QSANLRAERLEKELQSSSEQNTFLINKLHKAEREI 305
            K                        Q  ++  +RL+K L++S+++   L ++L   E E 
Sbjct: 734  KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793

Query: 306  NTLSSKVKELKHSNK----LEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAA 361
             TL   ++ELK S+K    LE  +  LE  +  S+LE+++ +++ E   L+   EI    
Sbjct: 794  QTLQKNLEELKISSKRLEQLEKENKSLE--QETSQLEKDKKQLEKENKRLRQQAEIKDTT 851

Query: 362  VEHHKVLL--VEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWR 419
            +E + V +  +EK+ + + K     +E   +L  L+ E  EL      +++  ++     
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL------VKRATIDIKTLV 905

Query: 420  QSEKDQYEEKLRASQMAEEITR--KELQSVRLKLQQQIVTIENAEK------EKNENSDL 471
               +D   EKL+  QM  ++ +   EL+ + L  ++ +   ++ +       E    S L
Sbjct: 906  TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL 965

Query: 472  KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRS-QAEKAQLEAEKTLEE 530
            K+ +   + ++ +L     +  N NQ L++ ++ +K+     +  Q E+  +++   +  
Sbjct: 966  KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1025

Query: 531  KQIQWLEEKH-------KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLK---- 579
            +  +W  E         K+ +R+ +  E+ N   +  ++A   Q K+     N L+    
Sbjct: 1026 EDNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084

Query: 580  -------RLQEKVEVLEAKKEELETENQVLNRQN 606
                    LQE+   L+ +  +L+ EN  LN Q+
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118



 Score =  115 bits (288), Expect = 1e-25
 Identities = 142/627 (22%), Positives = 298/627 (47%), Gaps = 84/627 (13%)

Query: 64  VKLQNELKHLFNEKQTQQEKLQLL---LEELRGELVEKTKDLEEMKLQI--LTPQKLELL 118
           +K     +HL  E    + K++ L   LEE   +L++  ++LE+M++++  L  + + LL
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299

Query: 119 ----RAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILD 174
                A++ ++    +RE+   +D ++E   + Y +  ++  F K+  E  KE+   +L+
Sbjct: 300 SDARSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE 358

Query: 175 ---------EGKIKYESEIARLEEDKEELRNQLLNVDLTK--DSKRVEQLAREKVYL--C 221
                    EG      ++  LE++  +L+ +L ++++ +  D K++E+L  E + L   
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418

Query: 222 QKLKGLEA-----EVAELKAEKENSEA------------------QVENAQRIQVRQLAE 258
           QK    E+     E+ ++    E SEA                  ++E   +   + + E
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478

Query: 259 MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL-KH 317
           ++ TV S+E        +  ++EKE Q  S++   L N++ + ++ +    +  K+L K 
Sbjct: 479 LRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534

Query: 318 SNKLEITDIKLETARAKSE-----LERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEK 372
             +LE T   +ET R  SE     LE+E   +   +  L+  ++I   A    +V  +EK
Sbjct: 535 KAQLEKT---IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA----RVKDIEK 587

Query: 373 DRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRA 432
           + +++ +   + +E   KL  ++ EK ++        K ++EH   +    ++ E +L  
Sbjct: 588 ENKILHE---SIKETSSKLSKIEFEKRQI--------KKELEHYKEKGERAEELENELHH 636

Query: 433 SQMAEEITRKELQSVRLKLQQ-QIVTIENAEKEKNENSDLKQQISS---LQIQVTSLAQS 488
            +   E+ +K++ ++++  ++ + +  EN+E E+ EN  LK+ + S   L  Q+ SL + 
Sbjct: 637 LEKENELLQKKITNLKITCEKIEALEQENSELER-ENRKLKKTLDSFKNLTFQLESLEKE 695

Query: 489 ENDLLNSNQMLKEMVERLK-QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERIT 547
            + L   N  L+  VE LK    +  + Q E  +LE+EK   +K ++ L+   K  ER+ 
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755

Query: 548 DREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN---QVLNR 604
              +  +   ++LQ+      K+    E++L+ L+ + + L+   EEL+  +   + L +
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815

Query: 605 QNVPFEDYT-RLQKRLKDIQRRHNEFR 630
           +N   E  T +L+K  K +++ +   R
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLR 842



 Score =  115 bits (287), Expect = 2e-25
 Identities = 158/666 (23%), Positives = 292/666 (43%), Gaps = 99/666 (14%)

Query: 32   QKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEEL 91
            QK + + ++ CE  +A    L+ E++ L+ E+ KL+  L   F     Q E L+    +L
Sbjct: 645  QKKITNLKITCEKIEA----LEQENSELERENRKLKKTLDS-FKNLTFQLESLEKENSQL 699

Query: 92   RGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMR--ERFRNLDEEVEKYRAVYN 149
              E +E  +++E +K   +   +L+L   +++ E E   +  E  +   ++ E+    Y 
Sbjct: 700  DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759

Query: 150  KLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKR 209
             L  E+  L+   E+  ++  ++        ESE+  LE + + L+  L  + ++  SKR
Sbjct: 760  GLDIENQRLQKTLENSNKKIQQL--------ESELQDLEMENQTLQKNLEELKIS--SKR 809

Query: 210  VEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAE 269
            +EQL +E   L Q+   LE +  +L+ E +    Q E    I+   L E    + +LE E
Sbjct: 810  LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE----IKDTTLEENNVKIGNLEKE 865

Query: 270  KQSAN----------LRAERLEKELQSSSEQNTFLI---------------------NKL 298
             ++ +          +R + LEKE +   ++ T  I                     N L
Sbjct: 866  NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925

Query: 299  HKAEREINTLSSKVKELKHS------NKLEITDIKLETARAKS-ELERER-----NKIQS 346
             K   E+  +    + L H       ++ ++ + KLE+   KS E++ E+      +++ 
Sbjct: 926  EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
              +  Q   + LK   ++++ L   +D E  R VQ++        +  +D K E E++  
Sbjct: 986  STNYNQQLRQELKTVKKNYEALKQRQDEE--RMVQSSPP------ISGEDNKWERESQET 1037

Query: 407  DLEKMKVEH---DVWRQSEKDQYEEKLRASQMAE-EITRKELQSVRLKLQQQIVTIENAE 462
              E +KV+    +V R +   Q E++   +Q+ + E     LQ+  L LQ+Q V+++   
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097

Query: 463  --------KEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFR 514
                    K + ENS L  Q +SL  Q   L   ++ L N N+ + +  E LK    +  
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157

Query: 515  SQAEKAQLEAEKTLEE-----KQIQWLEEKHK-LHERITDREEKYNQ-AKEKLQRAAIAQ 567
               EK +L  E+   E      +   L+  HK L     D E++YNQ  K+K Q   +  
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL-- 1215

Query: 568  KKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHN 627
            +K   + + K+    +  E + A+ ++L  EN  LN        Y++L K  + +Q  H 
Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN------HTYSQLLKETEVLQTDHK 1269

Query: 628  EFRSLI 633
              +SL+
Sbjct: 1270 NLKSLL 1275



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 94/440 (21%), Positives = 187/440 (42%), Gaps = 81/440 (18%)

Query: 266 LEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITD 325
           L  E   A  +  RL +EL+  +EQ       L   ++E+  +  ++K L+  N   ++D
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 326 IK--------LETARAKS----ELERERNKIQSELDGLQSDNEILKAAVEHHKVLL---- 369
            +        L+  R K+    +LE E ++ +  L  ++     ++   E ++VLL    
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 370 -----VEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKD 424
                +E  R    K+   ++E  Q    L D ++E +     +E++  E+     ++K 
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421

Query: 425 QYEEKLRASQMAEEITR----KELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
             +E L      E+I+R     E     L  +   +T     K + EN  L + +  L+ 
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481

Query: 481 QVTSLAQSENDLL---NSNQMLKEMVERLK----------QECRNFRSQAEKAQLEAEKT 527
            V S+  + + +L     NQ L + VE L+          Q C+N      K + + EKT
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541

Query: 528 LE------EKQIQWLEEKHK-LHERITDREEKYNQAKEKLQRAAIAQKKRKSLHE----- 575
           +E      E+QI+ LE++++ L++ ++   ++   + E   R    +K+ K LHE     
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE--ARVKDIEKENKILHESIKET 599

Query: 576 -NKLKRLQ-----------------EKVEVLEAKKEELETENQVLNRQ----NVPFEDYT 613
            +KL +++                 E+ E LE +   LE EN++L ++     +  E   
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIE 659

Query: 614 RLQKRLKDIQRRHNEFRSLI 633
            L++   +++R + + +  +
Sbjct: 660 ALEQENSELERENRKLKKTL 679



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 116/522 (22%), Positives = 225/522 (43%), Gaps = 35/522 (6%)

Query: 181 ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
           +++I RL ++ EE   QLL+       + +EQ+  E   L Q+   L ++    +  ++ 
Sbjct: 257 KAKIRRLRQELEEKTEQLLDC-----KQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311

Query: 241 SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHK 300
            +A  E A R+   +    +   R  + E   A  R E L+++ Q   E  T L ++L  
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLEDQLEG 369

Query: 301 AEREINTLSSKVKE-LKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILK 359
                + L    KE L+   KL   +++ +  R K E   E N +  E+   QS +E L 
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN-MTLEMAQKQSMDESLH 428

Query: 360 AAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWR 419
              E  ++    +  EL    Q +      +L   +  KLE+EN+   L K   E     
Sbjct: 429 LGWELEQI---SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ--SLTKTVEELRTTV 483

Query: 420 QSEKDQYEEKLRASQMAEEITRKE--LQSVRLKLQQQIVTIENAEKE-KNENSDLKQQIS 476
            S +    + L+  +  + +++K   L++  ++ +Q +   +N  K+   E + L++ I 
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543

Query: 477 SLQI---QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQL-EAEKTLEEKQ 532
           +L+    +   + + EN+ LN          ++  E R    + E   L E+ K    K 
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603

Query: 533 IQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQ---EKVEVLE 589
            +   EK ++ + +   +EK  +A E+L+      +K   L + K+  L+   EK+E LE
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIEALE 662

Query: 590 AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            +  ELE EN+ L +     + +  L  +L+ +++ +++        N+    ++  +  
Sbjct: 663 QENSELERENRKLKK---TLDSFKNLTFQLESLEKENSQLDE----ENLELRRNVESLKC 715

Query: 650 QSSAMVPSMELPFPPHMQEEQHQRELSLLR---KRLEELETT 688
            S  M            ++EQ ++ L LL+   K+ E LE +
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 39/182 (21%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 26   GSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEK---QTQQE 82
            G   + +KML  E+ +      N++T+ AE+ +L  E+ +L +    L  E    QT  +
Sbjct: 1210 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1269

Query: 83   KLQLLLEELRGELVEKTKDLEEMKLQI----LTPQKLELLRAQIQQELETPMRERFRNLD 138
             L+ LL   + E      +  ++K Q     +T  KL   + ++  +L+  + E  R+L 
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHLL 1328

Query: 139  EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL 198
            ++++        L  ++   K  F  ++ +Y   L+E           L   KE+L  ++
Sbjct: 1329 DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-----------LRRQKEKLEEKI 1377

Query: 199  LN 200
            ++
Sbjct: 1378 MD 1379


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  118 bits (295), Expect = 2e-26
 Identities = 165/758 (21%), Positives = 328/758 (43%), Gaps = 122/758 (16%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K   Q  + E   L+ +H +L  E K+L  E+   + +L    EE+R  L  K ++LEE+
Sbjct: 865  KERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              ++    + E  R Q  Q     M ++  +L+E++E+  A   KL+ E    +++ +  
Sbjct: 924  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQL-----------------------LNVD 202
            ++E   ++D+   K   E   LEE   +L   L                       L V 
Sbjct: 984  EDEIL-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042

Query: 203  LTKDSKRVEQLAREKVYL-------CQKLKGLEAEVAELKAEKENSEAQVENA------- 248
            L K+ K  ++L + K  L        +++  L+A++AELK +    E +++ A       
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 249  ---QRIQVRQLAEMQATVRSLE------------AEKQSANL--RAERLEKELQSSSEQN 291
               +   ++++ E++  +  L+            AEKQ  +L    E L+ EL+ + +  
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETA--------------RAKSEL 337
                    K E+E+  L   + E   S++ ++ +++ + A              RAK+ L
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 338  ERERNKIQSELDGLQSDNEIL---KAAVEHHKVLLVEKDRELIRKV---QAAKEEGYQKL 391
            ++ +  ++ E   L  +  +L   K  VEH K  L  + +EL  K    + A+ E   K+
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 392  VVLQDEKLELENRLADLE--KMKVEHDVWRQSEKDQYEEKLRASQMAEEIT----RKELQ 445
              LQ+E   +   L + E   +K+  DV   S + Q  ++L   +  +++      ++L+
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
              R  LQ Q+      ++E     +L++ IS+L IQ++   +   D  ++ + L+E  +R
Sbjct: 1343 EERNSLQDQL------DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 506  LKQECRNFRSQAEK---AQLEAEKTLEEKQ------IQWLEEKHKLHERITDREEKYNQ- 555
             ++E  N   Q E+   A  + EKT    Q      +  L+ + +L   +  ++ K++Q 
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 556  -AKEKLQRAAIAQKKRKS-----LHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
             A+EK   +  A ++ ++       E K   L   +E     KEELE  N++L  +    
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 610  --------EDYTRLQKRLKDIQRRHNEFRSLI--LVPNMPPTASINPVSFQSSAMVPSME 659
                    ++   L+K  + ++ +  E ++ +  L   +  T        +    + +++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALK 1573

Query: 660  LPFPPHMQ--EEQHQRELSLLRKRLEELET---TQRKQ 692
              F   +Q  +EQ++ +   L+++L E ET    +RKQ
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611



 Score =  103 bits (257), Expect = 5e-22
 Identities = 162/758 (21%), Positives = 308/758 (40%), Gaps = 107/758 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANY----QTLKAEHTRLQNEHVKLQNELKHLFNEKQT 79
            L G  S+F + + D + +    K       + L+A   RL +E  +  N LK +  E + 
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEG 1118

Query: 80   QQEKLQLLLEE---LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERF-- 134
                LQ  L+     R +  ++ +DL E    + T  +  L     QQEL     +    
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178

Query: 135  --RNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI---LDEGKIKYESEIARL-- 187
              + LDEE   + A   ++R +H     E   Q E++ R    LD+ K   E E A L  
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 188  ------------EEDKEELRNQLLNVDLT-KDSKRVEQLAREKVYLCQK--------LKG 226
                        E  K++L  Q+  +     D +R      +KV+  Q         L  
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 227  LEAEVAELKAEKENSEAQVENAQRI---QVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
             E +  +L  +  +  +Q+++ Q +   + RQ   +   +R LE E+ S   + +  E E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EME 1357

Query: 284  LQSSSEQNTFLIN-KLHKAEREINTLSSKVKELKHSNKL------EITDIKLETARAKSE 336
             + + E++   +N +L  +++++   +S V+ L+   K        +T    E A A  +
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417

Query: 337  LERERNKIQSELDGLQSD--------------------------NEILKAAVEHHKVLLV 370
            LE+ +N++Q ELD L  D                          N   K A E  +    
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477

Query: 371  EKDREL--------IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSE 422
             +++E         + +   AKEE  +   +L+ E  +L +   D+ K   E +  +++ 
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 423  KDQYEE-KLRASQMAEEITRKELQSVRLKLQQQIVT--IENAEKEKNENSDLKQQISSLQ 479
            + Q EE K +  ++ +E+   E   +RL++  Q +    E   + ++E ++ K++   LQ
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQ 1595

Query: 480  IQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE---KAQLEAEKTLEEKQIQWL 536
             Q+        D      +     ++L+ + ++   QA+   K + EA K L + Q Q  
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 537  EEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
            + + +L +    R+E +  AKE        +KK KSL E  L +LQE +   E  +++ +
Sbjct: 1656 DFQRELEDARASRDEIFATAKEN-------EKKAKSL-EADLMQLQEDLAAAERARKQAD 1707

Query: 597  TENQ--------VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVS 648
             E +         L+ +N   ++  RL+ R+  ++    E +  +   +     +     
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 649  FQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
              S+ +              +Q +R+   LR +L E+E
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 124/521 (23%), Positives = 216/521 (41%), Gaps = 111/521 (21%)

Query: 275  LRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKL------------- 321
            L+  R E+E+Q+  ++      +  KAE E+  L  K  +L     L             
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 322  EITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDREL----- 376
            E  ++++  A  K ELE   +++++ L+  +   + L+A  +     +++ + +L     
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 377  -IRKVQAAKEEGYQKLVVLQDEKLE--------------LENRLAD-------------- 407
              +K+Q  K     K+  L+DE L               LE R++D              
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 408  LEKMKVEHDVW--------RQSEKDQYE-EKLR------ASQMAEEIT------------ 440
            L K+K +H+          ++ EK + E EKL+      AS   E+I             
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 441  ----RKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSN 496
                 +ELQ+   +L  +I    NA K+  E   L+  IS LQ  + S   + N      
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 497  QMLKEMVERLK-------------QECRNFRSQ---AEKAQLEAEKTLEEKQIQWLEEKH 540
            + L E +E LK             QE R  R Q     K  L+ E    E Q+Q + +KH
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 541  -KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN 599
             +  E +T++ E++ +AK  L +     +K  +    +L+ L +  + +E KK++LE + 
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 600  QVLNRQNVPFEDYTRLQKRLKD-IQRRHNEFRSLILVPNMPPTASI---NPVSFQSSAMV 655
            Q L  +     D  R +  L D + +  NE  S+  + N     +I     V+  SS + 
Sbjct: 1262 QELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 656  PSMELPFPPHMQEEQHQR-ELSLLRKRLEELETTQRKQLEE 695
             + EL     +QEE  Q+  +S   ++LEE   + + QL+E
Sbjct: 1319 DTQEL-----LQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/307 (24%), Positives = 133/307 (43%), Gaps = 44/307 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            L     +FQ+ L D R   +   A  +  + +   L+ + ++LQ +L      ++    +
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETP------MRERFRNL 137
             + L EEL   L  +    +E +       +LE   AQ+++ELE        M +R R  
Sbjct: 1710 KEELAEELASSLSGRNALQDEKR-------RLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 138  DEEVEKYR---AVYNKLRYEHTFLKSEFEHQKEEYARILDEG----KIKYESEIARLEED 190
             ++ E+     A       ++   + + E Q +E    L E     K K++S IA LE  
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822

Query: 191  KEELRNQLLNVDLTKDSKRVEQLAREK----VYLCQKLKGLEAEVAELKAEKENSEAQVE 246
              +L  Q            VEQ AREK      L QK K L+  + +++ E++ +E   E
Sbjct: 1823 IAQLEEQ------------VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870

Query: 247  NAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
             A++   R + +++  +   E E Q  N    +L++EL  ++E N  +        RE+N
Sbjct: 1871 QAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM-------GREVN 1922

Query: 307  TLSSKVK 313
             L SK++
Sbjct: 1923 ALKSKLR 1929



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/365 (23%), Positives = 160/365 (43%), Gaps = 50/365 (13%)

Query: 37   DERLRCEHHKANYQTLKAEHTR------LQNEHVK--LQNELKHLFNEKQTQQEKLQLLL 88
            D +LR E    N Q LK +  R       QNE  +  LQ +L H +  +   + K + L 
Sbjct: 1560 DAKLRLE---VNMQALKGQFERDLQARDEQNEEKRRQLQRQL-HEYETELEDERKQRALA 1615

Query: 89   EELRGELVEKTKDLE-----EMKLQILTPQKLELLRAQI---QQELETPMRER---FRNL 137
               + +L    KDLE      +K +    ++L  L+AQ+   Q+ELE     R   F   
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 138  DEEVEKYRAVYNKLRYEHTFL------KSEFEHQKEEYAR----------ILDEGKIKYE 181
             E  +K +++   L      L      + + + +KEE A            L + K + E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 182  SEIARLEEDKEELRNQL--LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKE 239
            + IA+LEE+ EE +  +  ++  + K +++ EQL+ E     ++    + E A  + E++
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA--TERSTAQKNESARQQLERQ 1793

Query: 240  NSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH 299
            N E +      ++    ++ ++T+ +LEA+      + E+  +E Q++++       KL 
Sbjct: 1794 NKELR-SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852

Query: 300  KAEREINT---LSSKVKELKHSNKLEITDIKLETARAKSELER---ERNKIQSELDGLQS 353
            +   ++     ++ + KE        +  +K +   A+ E +R    R K+Q ELD    
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912

Query: 354  DNEIL 358
             NE +
Sbjct: 1913 SNEAM 1917



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 47/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)

Query: 503  VERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK--------LHERITDREEKYN 554
            V R ++E +    + +K +   +K   E +++ LE+KH         L E++    E Y 
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKA--ENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 555  QAKE-KLQRAAIAQKKRKSLHE-----------------------NKLKRLQEKVEVLEA 590
            +A+E +++ AA  Q+  + LHE                        ++  L+E++E  EA
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 591  KKEELETENQVLNRQNVPFED--------YTRLQKRLKDIQRRHNEFRSLILVPNMPPTA 642
             +++L+ E      +    ED          +L K  K ++ R ++  +  L        
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAK 1023

Query: 643  SINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
            ++  +  +  +M+  +E+      +EE+ ++EL  L+++LE   +   +Q+ +L
Sbjct: 1024 NLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  118 bits (295), Expect = 2e-26
 Identities = 165/758 (21%), Positives = 328/758 (43%), Gaps = 122/758 (16%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K   Q  + E   L+ +H +L  E K+L  E+   + +L    EE+R  L  K ++LEE+
Sbjct: 872  KERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              ++    + E  R Q  Q     M ++  +L+E++E+  A   KL+ E    +++ +  
Sbjct: 931  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQL-----------------------LNVD 202
            ++E   ++D+   K   E   LEE   +L   L                       L V 
Sbjct: 991  EDEIL-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049

Query: 203  LTKDSKRVEQLAREKVYL-------CQKLKGLEAEVAELKAEKENSEAQVENA------- 248
            L K+ K  ++L + K  L        +++  L+A++AELK +    E +++ A       
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 249  ---QRIQVRQLAEMQATVRSLE------------AEKQSANL--RAERLEKELQSSSEQN 291
               +   ++++ E++  +  L+            AEKQ  +L    E L+ EL+ + +  
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETA--------------RAKSEL 337
                    K E+E+  L   + E   S++ ++ +++ + A              RAK+ L
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 338  ERERNKIQSELDGLQSDNEIL---KAAVEHHKVLLVEKDRELIRKV---QAAKEEGYQKL 391
            ++ +  ++ E   L  +  +L   K  VEH K  L  + +EL  K    + A+ E   K+
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 392  VVLQDEKLELENRLADLE--KMKVEHDVWRQSEKDQYEEKLRASQMAEEIT----RKELQ 445
              LQ+E   +   L + E   +K+  DV   S + Q  ++L   +  +++      ++L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
              R  LQ Q+      ++E     +L++ IS+L IQ++   +   D  ++ + L+E  +R
Sbjct: 1350 EERNSLQDQL------DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 506  LKQECRNFRSQAEK---AQLEAEKTLEEKQ------IQWLEEKHKLHERITDREEKYNQ- 555
             ++E  N   Q E+   A  + EKT    Q      +  L+ + +L   +  ++ K++Q 
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 556  -AKEKLQRAAIAQKKRKS-----LHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
             A+EK   +  A ++ ++       E K   L   +E     KEELE  N++L  +    
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 610  --------EDYTRLQKRLKDIQRRHNEFRSLI--LVPNMPPTASINPVSFQSSAMVPSME 659
                    ++   L+K  + ++ +  E ++ +  L   +  T        +    + +++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALK 1580

Query: 660  LPFPPHMQ--EEQHQRELSLLRKRLEELET---TQRKQ 692
              F   +Q  +EQ++ +   L+++L E ET    +RKQ
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618



 Score =  103 bits (257), Expect = 5e-22
 Identities = 162/758 (21%), Positives = 308/758 (40%), Gaps = 107/758 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANY----QTLKAEHTRLQNEHVKLQNELKHLFNEKQT 79
            L G  S+F + + D + +    K       + L+A   RL +E  +  N LK +  E + 
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEG 1125

Query: 80   QQEKLQLLLEE---LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERF-- 134
                LQ  L+     R +  ++ +DL E    + T  +  L     QQEL     +    
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185

Query: 135  --RNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI---LDEGKIKYESEIARL-- 187
              + LDEE   + A   ++R +H     E   Q E++ R    LD+ K   E E A L  
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 188  ------------EEDKEELRNQLLNVDLT-KDSKRVEQLAREKVYLCQK--------LKG 226
                        E  K++L  Q+  +     D +R      +KV+  Q         L  
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 227  LEAEVAELKAEKENSEAQVENAQRI---QVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
             E +  +L  +  +  +Q+++ Q +   + RQ   +   +R LE E+ S   + +  E E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EME 1364

Query: 284  LQSSSEQNTFLIN-KLHKAEREINTLSSKVKELKHSNKL------EITDIKLETARAKSE 336
             + + E++   +N +L  +++++   +S V+ L+   K        +T    E A A  +
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424

Query: 337  LERERNKIQSELDGLQSD--------------------------NEILKAAVEHHKVLLV 370
            LE+ +N++Q ELD L  D                          N   K A E  +    
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 371  EKDREL--------IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSE 422
             +++E         + +   AKEE  +   +L+ E  +L +   D+ K   E +  +++ 
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 423  KDQYEE-KLRASQMAEEITRKELQSVRLKLQQQIVT--IENAEKEKNENSDLKQQISSLQ 479
            + Q EE K +  ++ +E+   E   +RL++  Q +    E   + ++E ++ K++   LQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQ 1602

Query: 480  IQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE---KAQLEAEKTLEEKQIQWL 536
             Q+        D      +     ++L+ + ++   QA+   K + EA K L + Q Q  
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 537  EEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
            + + +L +    R+E +  AKE        +KK KSL E  L +LQE +   E  +++ +
Sbjct: 1663 DFQRELEDARASRDEIFATAKEN-------EKKAKSL-EADLMQLQEDLAAAERARKQAD 1714

Query: 597  TENQ--------VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVS 648
             E +         L+ +N   ++  RL+ R+  ++    E +  +   +     +     
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 649  FQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
              S+ +              +Q +R+   LR +L E+E
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 124/521 (23%), Positives = 216/521 (41%), Gaps = 111/521 (21%)

Query: 275  LRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKL------------- 321
            L+  R E+E+Q+  ++      +  KAE E+  L  K  +L     L             
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 322  EITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDREL----- 376
            E  ++++  A  K ELE   +++++ L+  +   + L+A  +     +++ + +L     
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 377  -IRKVQAAKEEGYQKLVVLQDEKLE--------------LENRLAD-------------- 407
              +K+Q  K     K+  L+DE L               LE R++D              
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 408  LEKMKVEHDVW--------RQSEKDQYE-EKLR------ASQMAEEIT------------ 440
            L K+K +H+          ++ EK + E EKL+      AS   E+I             
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 441  ----RKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSN 496
                 +ELQ+   +L  +I    NA K+  E   L+  IS LQ  + S   + N      
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 497  QMLKEMVERLK-------------QECRNFRSQ---AEKAQLEAEKTLEEKQIQWLEEKH 540
            + L E +E LK             QE R  R Q     K  L+ E    E Q+Q + +KH
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 541  -KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN 599
             +  E +T++ E++ +AK  L +     +K  +    +L+ L +  + +E KK++LE + 
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 600  QVLNRQNVPFEDYTRLQKRLKD-IQRRHNEFRSLILVPNMPPTASI---NPVSFQSSAMV 655
            Q L  +     D  R +  L D + +  NE  S+  + N     +I     V+  SS + 
Sbjct: 1269 QELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 656  PSMELPFPPHMQEEQHQR-ELSLLRKRLEELETTQRKQLEE 695
             + EL     +QEE  Q+  +S   ++LEE   + + QL+E
Sbjct: 1326 DTQEL-----LQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/307 (24%), Positives = 133/307 (43%), Gaps = 44/307 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            L     +FQ+ L D R   +   A  +  + +   L+ + ++LQ +L      ++    +
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETP------MRERFRNL 137
             + L EEL   L  +    +E +       +LE   AQ+++ELE        M +R R  
Sbjct: 1717 KEELAEELASSLSGRNALQDEKR-------RLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 138  DEEVEKYR---AVYNKLRYEHTFLKSEFEHQKEEYARILDEG----KIKYESEIARLEED 190
             ++ E+     A       ++   + + E Q +E    L E     K K++S IA LE  
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 191  KEELRNQLLNVDLTKDSKRVEQLAREK----VYLCQKLKGLEAEVAELKAEKENSEAQVE 246
              +L  Q            VEQ AREK      L QK K L+  + +++ E++ +E   E
Sbjct: 1830 IAQLEEQ------------VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877

Query: 247  NAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
             A++   R + +++  +   E E Q  N    +L++EL  ++E N  +        RE+N
Sbjct: 1878 QAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM-------GREVN 1929

Query: 307  TLSSKVK 313
             L SK++
Sbjct: 1930 ALKSKLR 1936



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/365 (23%), Positives = 160/365 (43%), Gaps = 50/365 (13%)

Query: 37   DERLRCEHHKANYQTLKAEHTR------LQNEHVK--LQNELKHLFNEKQTQQEKLQLLL 88
            D +LR E    N Q LK +  R       QNE  +  LQ +L H +  +   + K + L 
Sbjct: 1567 DAKLRLE---VNMQALKGQFERDLQARDEQNEEKRRQLQRQL-HEYETELEDERKQRALA 1622

Query: 89   EELRGELVEKTKDLE-----EMKLQILTPQKLELLRAQI---QQELETPMRER---FRNL 137
               + +L    KDLE      +K +    ++L  L+AQ+   Q+ELE     R   F   
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 138  DEEVEKYRAVYNKLRYEHTFL------KSEFEHQKEEYAR----------ILDEGKIKYE 181
             E  +K +++   L      L      + + + +KEE A            L + K + E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 182  SEIARLEEDKEELRNQL--LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKE 239
            + IA+LEE+ EE +  +  ++  + K +++ EQL+ E     ++    + E A  + E++
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA--TERSTAQKNESARQQLERQ 1800

Query: 240  NSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH 299
            N E +      ++    ++ ++T+ +LEA+      + E+  +E Q++++       KL 
Sbjct: 1801 NKELR-SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859

Query: 300  KAEREINT---LSSKVKELKHSNKLEITDIKLETARAKSELER---ERNKIQSELDGLQS 353
            +   ++     ++ + KE        +  +K +   A+ E +R    R K+Q ELD    
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919

Query: 354  DNEIL 358
             NE +
Sbjct: 1920 SNEAM 1924



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 47/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)

Query: 503  VERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK--------LHERITDREEKYN 554
            V R ++E +    + +K +   +K   E +++ LE+KH         L E++    E Y 
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKA--ENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 555  QAKE-KLQRAAIAQKKRKSLHE-----------------------NKLKRLQEKVEVLEA 590
            +A+E +++ AA  Q+  + LHE                        ++  L+E++E  EA
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 591  KKEELETENQVLNRQNVPFED--------YTRLQKRLKDIQRRHNEFRSLILVPNMPPTA 642
             +++L+ E      +    ED          +L K  K ++ R ++  +  L        
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAK 1030

Query: 643  SINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
            ++  +  +  +M+  +E+      +EE+ ++EL  L+++LE   +   +Q+ +L
Sbjct: 1031 NLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  118 bits (295), Expect = 2e-26
 Identities = 165/758 (21%), Positives = 328/758 (43%), Gaps = 122/758 (16%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K   Q  + E   L+ +H +L  E K+L  E+   + +L    EE+R  L  K ++LEE+
Sbjct: 872  KERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              ++    + E  R Q  Q     M ++  +L+E++E+  A   KL+ E    +++ +  
Sbjct: 931  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQL-----------------------LNVD 202
            ++E   ++D+   K   E   LEE   +L   L                       L V 
Sbjct: 991  EDEIL-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049

Query: 203  LTKDSKRVEQLAREKVYL-------CQKLKGLEAEVAELKAEKENSEAQVENA------- 248
            L K+ K  ++L + K  L        +++  L+A++AELK +    E +++ A       
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 249  ---QRIQVRQLAEMQATVRSLE------------AEKQSANL--RAERLEKELQSSSEQN 291
               +   ++++ E++  +  L+            AEKQ  +L    E L+ EL+ + +  
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETA--------------RAKSEL 337
                    K E+E+  L   + E   S++ ++ +++ + A              RAK+ L
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 338  ERERNKIQSELDGLQSDNEIL---KAAVEHHKVLLVEKDRELIRKV---QAAKEEGYQKL 391
            ++ +  ++ E   L  +  +L   K  VEH K  L  + +EL  K    + A+ E   K+
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 392  VVLQDEKLELENRLADLE--KMKVEHDVWRQSEKDQYEEKLRASQMAEEIT----RKELQ 445
              LQ+E   +   L + E   +K+  DV   S + Q  ++L   +  +++      ++L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
              R  LQ Q+      ++E     +L++ IS+L IQ++   +   D  ++ + L+E  +R
Sbjct: 1350 EERNSLQDQL------DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 506  LKQECRNFRSQAEK---AQLEAEKTLEEKQ------IQWLEEKHKLHERITDREEKYNQ- 555
             ++E  N   Q E+   A  + EKT    Q      +  L+ + +L   +  ++ K++Q 
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 556  -AKEKLQRAAIAQKKRKS-----LHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
             A+EK   +  A ++ ++       E K   L   +E     KEELE  N++L  +    
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 610  --------EDYTRLQKRLKDIQRRHNEFRSLI--LVPNMPPTASINPVSFQSSAMVPSME 659
                    ++   L+K  + ++ +  E ++ +  L   +  T        +    + +++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALK 1580

Query: 660  LPFPPHMQ--EEQHQRELSLLRKRLEELET---TQRKQ 692
              F   +Q  +EQ++ +   L+++L E ET    +RKQ
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618



 Score =  103 bits (257), Expect = 5e-22
 Identities = 162/758 (21%), Positives = 308/758 (40%), Gaps = 107/758 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANY----QTLKAEHTRLQNEHVKLQNELKHLFNEKQT 79
            L G  S+F + + D + +    K       + L+A   RL +E  +  N LK +  E + 
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEG 1125

Query: 80   QQEKLQLLLEE---LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERF-- 134
                LQ  L+     R +  ++ +DL E    + T  +  L     QQEL     +    
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185

Query: 135  --RNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI---LDEGKIKYESEIARL-- 187
              + LDEE   + A   ++R +H     E   Q E++ R    LD+ K   E E A L  
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 188  ------------EEDKEELRNQLLNVDLT-KDSKRVEQLAREKVYLCQK--------LKG 226
                        E  K++L  Q+  +     D +R      +KV+  Q         L  
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 227  LEAEVAELKAEKENSEAQVENAQRI---QVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
             E +  +L  +  +  +Q+++ Q +   + RQ   +   +R LE E+ S   + +  E E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EME 1364

Query: 284  LQSSSEQNTFLIN-KLHKAEREINTLSSKVKELKHSNKL------EITDIKLETARAKSE 336
             + + E++   +N +L  +++++   +S V+ L+   K        +T    E A A  +
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424

Query: 337  LERERNKIQSELDGLQSD--------------------------NEILKAAVEHHKVLLV 370
            LE+ +N++Q ELD L  D                          N   K A E  +    
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 371  EKDREL--------IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSE 422
             +++E         + +   AKEE  +   +L+ E  +L +   D+ K   E +  +++ 
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 423  KDQYEE-KLRASQMAEEITRKELQSVRLKLQQQIVT--IENAEKEKNENSDLKQQISSLQ 479
            + Q EE K +  ++ +E+   E   +RL++  Q +    E   + ++E ++ K++   LQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQ 1602

Query: 480  IQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE---KAQLEAEKTLEEKQIQWL 536
             Q+        D      +     ++L+ + ++   QA+   K + EA K L + Q Q  
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 537  EEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
            + + +L +    R+E +  AKE        +KK KSL E  L +LQE +   E  +++ +
Sbjct: 1663 DFQRELEDARASRDEIFATAKEN-------EKKAKSL-EADLMQLQEDLAAAERARKQAD 1714

Query: 597  TENQ--------VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVS 648
             E +         L+ +N   ++  RL+ R+  ++    E +  +   +     +     
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 649  FQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
              S+ +              +Q +R+   LR +L E+E
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 124/521 (23%), Positives = 216/521 (41%), Gaps = 111/521 (21%)

Query: 275  LRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKL------------- 321
            L+  R E+E+Q+  ++      +  KAE E+  L  K  +L     L             
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 322  EITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDREL----- 376
            E  ++++  A  K ELE   +++++ L+  +   + L+A  +     +++ + +L     
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 377  -IRKVQAAKEEGYQKLVVLQDEKLE--------------LENRLAD-------------- 407
              +K+Q  K     K+  L+DE L               LE R++D              
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 408  LEKMKVEHDVW--------RQSEKDQYE-EKLR------ASQMAEEIT------------ 440
            L K+K +H+          ++ EK + E EKL+      AS   E+I             
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 441  ----RKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSN 496
                 +ELQ+   +L  +I    NA K+  E   L+  IS LQ  + S   + N      
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 497  QMLKEMVERLK-------------QECRNFRSQ---AEKAQLEAEKTLEEKQIQWLEEKH 540
            + L E +E LK             QE R  R Q     K  L+ E    E Q+Q + +KH
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 541  -KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN 599
             +  E +T++ E++ +AK  L +     +K  +    +L+ L +  + +E KK++LE + 
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 600  QVLNRQNVPFEDYTRLQKRLKD-IQRRHNEFRSLILVPNMPPTASI---NPVSFQSSAMV 655
            Q L  +     D  R +  L D + +  NE  S+  + N     +I     V+  SS + 
Sbjct: 1269 QELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 656  PSMELPFPPHMQEEQHQR-ELSLLRKRLEELETTQRKQLEE 695
             + EL     +QEE  Q+  +S   ++LEE   + + QL+E
Sbjct: 1326 DTQEL-----LQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/307 (24%), Positives = 133/307 (43%), Gaps = 44/307 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            L     +FQ+ L D R   +   A  +  + +   L+ + ++LQ +L      ++    +
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETP------MRERFRNL 137
             + L EEL   L  +    +E +       +LE   AQ+++ELE        M +R R  
Sbjct: 1717 KEELAEELASSLSGRNALQDEKR-------RLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 138  DEEVEKYR---AVYNKLRYEHTFLKSEFEHQKEEYARILDEG----KIKYESEIARLEED 190
             ++ E+     A       ++   + + E Q +E    L E     K K++S IA LE  
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 191  KEELRNQLLNVDLTKDSKRVEQLAREK----VYLCQKLKGLEAEVAELKAEKENSEAQVE 246
              +L  Q            VEQ AREK      L QK K L+  + +++ E++ +E   E
Sbjct: 1830 IAQLEEQ------------VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877

Query: 247  NAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
             A++   R + +++  +   E E Q  N    +L++EL  ++E N  +        RE+N
Sbjct: 1878 QAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM-------GREVN 1929

Query: 307  TLSSKVK 313
             L SK++
Sbjct: 1930 ALKSKLR 1936



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/365 (23%), Positives = 160/365 (43%), Gaps = 50/365 (13%)

Query: 37   DERLRCEHHKANYQTLKAEHTR------LQNEHVK--LQNELKHLFNEKQTQQEKLQLLL 88
            D +LR E    N Q LK +  R       QNE  +  LQ +L H +  +   + K + L 
Sbjct: 1567 DAKLRLE---VNMQALKGQFERDLQARDEQNEEKRRQLQRQL-HEYETELEDERKQRALA 1622

Query: 89   EELRGELVEKTKDLE-----EMKLQILTPQKLELLRAQI---QQELETPMRER---FRNL 137
               + +L    KDLE      +K +    ++L  L+AQ+   Q+ELE     R   F   
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 138  DEEVEKYRAVYNKLRYEHTFL------KSEFEHQKEEYAR----------ILDEGKIKYE 181
             E  +K +++   L      L      + + + +KEE A            L + K + E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 182  SEIARLEEDKEELRNQL--LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKE 239
            + IA+LEE+ EE +  +  ++  + K +++ EQL+ E     ++    + E A  + E++
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA--TERSTAQKNESARQQLERQ 1800

Query: 240  NSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH 299
            N E +      ++    ++ ++T+ +LEA+      + E+  +E Q++++       KL 
Sbjct: 1801 NKELR-SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859

Query: 300  KAEREINT---LSSKVKELKHSNKLEITDIKLETARAKSELER---ERNKIQSELDGLQS 353
            +   ++     ++ + KE        +  +K +   A+ E +R    R K+Q ELD    
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919

Query: 354  DNEIL 358
             NE +
Sbjct: 1920 SNEAM 1924



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 47/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)

Query: 503  VERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK--------LHERITDREEKYN 554
            V R ++E +    + +K +   +K   E +++ LE+KH         L E++    E Y 
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKA--ENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 555  QAKE-KLQRAAIAQKKRKSLHE-----------------------NKLKRLQEKVEVLEA 590
            +A+E +++ AA  Q+  + LHE                        ++  L+E++E  EA
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 591  KKEELETENQVLNRQNVPFED--------YTRLQKRLKDIQRRHNEFRSLILVPNMPPTA 642
             +++L+ E      +    ED          +L K  K ++ R ++  +  L        
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAK 1030

Query: 643  SINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
            ++  +  +  +M+  +E+      +EE+ ++EL  L+++LE   +   +Q+ +L
Sbjct: 1031 NLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  118 bits (295), Expect = 2e-26
 Identities = 165/758 (21%), Positives = 328/758 (43%), Gaps = 122/758 (16%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K   Q  + E   L+ +H +L  E K+L  E+   + +L    EE+R  L  K ++LEE+
Sbjct: 865  KERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
              ++    + E  R Q  Q     M ++  +L+E++E+  A   KL+ E    +++ +  
Sbjct: 924  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEELRNQL-----------------------LNVD 202
            ++E   ++D+   K   E   LEE   +L   L                       L V 
Sbjct: 984  EDEIL-VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042

Query: 203  LTKDSKRVEQLAREKVYL-------CQKLKGLEAEVAELKAEKENSEAQVENA------- 248
            L K+ K  ++L + K  L        +++  L+A++AELK +    E +++ A       
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 249  ---QRIQVRQLAEMQATVRSLE------------AEKQSANL--RAERLEKELQSSSEQN 291
               +   ++++ E++  +  L+            AEKQ  +L    E L+ EL+ + +  
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETA--------------RAKSEL 337
                    K E+E+  L   + E   S++ ++ +++ + A              RAK+ L
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 338  ERERNKIQSELDGLQSDNEIL---KAAVEHHKVLLVEKDRELIRKV---QAAKEEGYQKL 391
            ++ +  ++ E   L  +  +L   K  VEH K  L  + +EL  K    + A+ E   K+
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 392  VVLQDEKLELENRLADLE--KMKVEHDVWRQSEKDQYEEKLRASQMAEEIT----RKELQ 445
              LQ+E   +   L + E   +K+  DV   S + Q  ++L   +  +++      ++L+
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
              R  LQ Q+      ++E     +L++ IS+L IQ++   +   D  ++ + L+E  +R
Sbjct: 1343 EERNSLQDQL------DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 506  LKQECRNFRSQAEK---AQLEAEKTLEEKQ------IQWLEEKHKLHERITDREEKYNQ- 555
             ++E  N   Q E+   A  + EKT    Q      +  L+ + +L   +  ++ K++Q 
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 556  -AKEKLQRAAIAQKKRKS-----LHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
             A+EK   +  A ++ ++       E K   L   +E     KEELE  N++L  +    
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 610  --------EDYTRLQKRLKDIQRRHNEFRSLI--LVPNMPPTASINPVSFQSSAMVPSME 659
                    ++   L+K  + ++ +  E ++ +  L   +  T        +    + +++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALK 1573

Query: 660  LPFPPHMQ--EEQHQRELSLLRKRLEELET---TQRKQ 692
              F   +Q  +EQ++ +   L+++L E ET    +RKQ
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611



 Score =  103 bits (257), Expect = 5e-22
 Identities = 162/758 (21%), Positives = 308/758 (40%), Gaps = 107/758 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANY----QTLKAEHTRLQNEHVKLQNELKHLFNEKQT 79
            L G  S+F + + D + +    K       + L+A   RL +E  +  N LK +  E + 
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEG 1118

Query: 80   QQEKLQLLLEE---LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERF-- 134
                LQ  L+     R +  ++ +DL E    + T  +  L     QQEL     +    
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178

Query: 135  --RNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI---LDEGKIKYESEIARL-- 187
              + LDEE   + A   ++R +H     E   Q E++ R    LD+ K   E E A L  
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 188  ------------EEDKEELRNQLLNVDLT-KDSKRVEQLAREKVYLCQK--------LKG 226
                        E  K++L  Q+  +     D +R      +KV+  Q         L  
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 227  LEAEVAELKAEKENSEAQVENAQRI---QVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
             E +  +L  +  +  +Q+++ Q +   + RQ   +   +R LE E+ S   + +  E E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EME 1357

Query: 284  LQSSSEQNTFLIN-KLHKAEREINTLSSKVKELKHSNKL------EITDIKLETARAKSE 336
             + + E++   +N +L  +++++   +S V+ L+   K        +T    E A A  +
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417

Query: 337  LERERNKIQSELDGLQSD--------------------------NEILKAAVEHHKVLLV 370
            LE+ +N++Q ELD L  D                          N   K A E  +    
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477

Query: 371  EKDREL--------IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSE 422
             +++E         + +   AKEE  +   +L+ E  +L +   D+ K   E +  +++ 
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 423  KDQYEE-KLRASQMAEEITRKELQSVRLKLQQQIVT--IENAEKEKNENSDLKQQISSLQ 479
            + Q EE K +  ++ +E+   E   +RL++  Q +    E   + ++E ++ K++   LQ
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQ 1595

Query: 480  IQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE---KAQLEAEKTLEEKQIQWL 536
             Q+        D      +     ++L+ + ++   QA+   K + EA K L + Q Q  
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 537  EEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
            + + +L +    R+E +  AKE        +KK KSL E  L +LQE +   E  +++ +
Sbjct: 1656 DFQRELEDARASRDEIFATAKEN-------EKKAKSL-EADLMQLQEDLAAAERARKQAD 1707

Query: 597  TENQ--------VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVS 648
             E +         L+ +N   ++  RL+ R+  ++    E +  +   +     +     
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 649  FQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
              S+ +              +Q +R+   LR +L E+E
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 124/521 (23%), Positives = 216/521 (41%), Gaps = 111/521 (21%)

Query: 275  LRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKL------------- 321
            L+  R E+E+Q+  ++      +  KAE E+  L  K  +L     L             
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 322  EITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDREL----- 376
            E  ++++  A  K ELE   +++++ L+  +   + L+A  +     +++ + +L     
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 377  -IRKVQAAKEEGYQKLVVLQDEKLE--------------LENRLAD-------------- 407
              +K+Q  K     K+  L+DE L               LE R++D              
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 408  LEKMKVEHDVW--------RQSEKDQYE-EKLR------ASQMAEEIT------------ 440
            L K+K +H+          ++ EK + E EKL+      AS   E+I             
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 441  ----RKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSN 496
                 +ELQ+   +L  +I    NA K+  E   L+  IS LQ  + S   + N      
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 497  QMLKEMVERLK-------------QECRNFRSQ---AEKAQLEAEKTLEEKQIQWLEEKH 540
            + L E +E LK             QE R  R Q     K  L+ E    E Q+Q + +KH
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 541  -KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN 599
             +  E +T++ E++ +AK  L +     +K  +    +L+ L +  + +E KK++LE + 
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 600  QVLNRQNVPFEDYTRLQKRLKD-IQRRHNEFRSLILVPNMPPTASI---NPVSFQSSAMV 655
            Q L  +     D  R +  L D + +  NE  S+  + N     +I     V+  SS + 
Sbjct: 1262 QELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 656  PSMELPFPPHMQEEQHQR-ELSLLRKRLEELETTQRKQLEE 695
             + EL     +QEE  Q+  +S   ++LEE   + + QL+E
Sbjct: 1319 DTQEL-----LQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/307 (24%), Positives = 133/307 (43%), Gaps = 44/307 (14%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            L     +FQ+ L D R   +   A  +  + +   L+ + ++LQ +L      ++    +
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETP------MRERFRNL 137
             + L EEL   L  +    +E +       +LE   AQ+++ELE        M +R R  
Sbjct: 1710 KEELAEELASSLSGRNALQDEKR-------RLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 138  DEEVEKYR---AVYNKLRYEHTFLKSEFEHQKEEYARILDEG----KIKYESEIARLEED 190
             ++ E+     A       ++   + + E Q +E    L E     K K++S IA LE  
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822

Query: 191  KEELRNQLLNVDLTKDSKRVEQLAREK----VYLCQKLKGLEAEVAELKAEKENSEAQVE 246
              +L  Q            VEQ AREK      L QK K L+  + +++ E++ +E   E
Sbjct: 1823 IAQLEEQ------------VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870

Query: 247  NAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
             A++   R + +++  +   E E Q  N    +L++EL  ++E N  +        RE+N
Sbjct: 1871 QAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM-------GREVN 1922

Query: 307  TLSSKVK 313
             L SK++
Sbjct: 1923 ALKSKLR 1929



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/365 (23%), Positives = 160/365 (43%), Gaps = 50/365 (13%)

Query: 37   DERLRCEHHKANYQTLKAEHTR------LQNEHVK--LQNELKHLFNEKQTQQEKLQLLL 88
            D +LR E    N Q LK +  R       QNE  +  LQ +L H +  +   + K + L 
Sbjct: 1560 DAKLRLE---VNMQALKGQFERDLQARDEQNEEKRRQLQRQL-HEYETELEDERKQRALA 1615

Query: 89   EELRGELVEKTKDLE-----EMKLQILTPQKLELLRAQI---QQELETPMRER---FRNL 137
               + +L    KDLE      +K +    ++L  L+AQ+   Q+ELE     R   F   
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 138  DEEVEKYRAVYNKLRYEHTFL------KSEFEHQKEEYAR----------ILDEGKIKYE 181
             E  +K +++   L      L      + + + +KEE A            L + K + E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 182  SEIARLEEDKEELRNQL--LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKE 239
            + IA+LEE+ EE +  +  ++  + K +++ EQL+ E     ++    + E A  + E++
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA--TERSTAQKNESARQQLERQ 1793

Query: 240  NSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH 299
            N E +      ++    ++ ++T+ +LEA+      + E+  +E Q++++       KL 
Sbjct: 1794 NKELR-SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852

Query: 300  KAEREINT---LSSKVKELKHSNKLEITDIKLETARAKSELER---ERNKIQSELDGLQS 353
            +   ++     ++ + KE        +  +K +   A+ E +R    R K+Q ELD    
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912

Query: 354  DNEIL 358
             NE +
Sbjct: 1913 SNEAM 1917



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 47/234 (20%), Positives = 102/234 (43%), Gaps = 46/234 (19%)

Query: 503  VERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK--------LHERITDREEKYN 554
            V R ++E +    + +K +   +K   E +++ LE+KH         L E++    E Y 
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKA--ENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 555  QAKE-KLQRAAIAQKKRKSLHE-----------------------NKLKRLQEKVEVLEA 590
            +A+E +++ AA  Q+  + LHE                        ++  L+E++E  EA
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 591  KKEELETENQVLNRQNVPFED--------YTRLQKRLKDIQRRHNEFRSLILVPNMPPTA 642
             +++L+ E      +    ED          +L K  K ++ R ++  +  L        
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAK 1023

Query: 643  SINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
            ++  +  +  +M+  +E+      +EE+ ++EL  L+++LE   +   +Q+ +L
Sbjct: 1024 NLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  116 bits (290), Expect = 8e-26
 Identities = 136/631 (21%), Positives = 295/631 (46%), Gaps = 83/631 (13%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHV---KLQNELKHLFNEKQTQQEKLQL 86
            E  K  +DERL+    K +++ L A + R+++E     +LQ +LK L    +  +E+L+ 
Sbjct: 1070 ENDKQQLDERLK----KKDFE-LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124

Query: 87   ------LLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
                   +E+LR +L   +++LEE+  ++        ++ ++ ++ E   ++  R+L+E 
Sbjct: 1125 ERTARAKVEKLRSDL---SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1181

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLN 200
              ++ A    LR +H    +E   Q +   R+             +LE++K E + +L +
Sbjct: 1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ-----------KLEKEKSEFKLELDD 1230

Query: 201  VDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVEN--AQRIQV----- 253
            V     +  +EQ+ + K  L +  + LE ++ E +++ E ++  V +  +QR ++     
Sbjct: 1231 V-----TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1285

Query: 254  ---RQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSS 310
               RQL E +A +  L   K +   + E L+++L+   +    L + L  A  + + L  
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE 1345

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLV 370
            + +E   +      +++   ++A SE+ + R K   E D +Q   E+     E  K  L 
Sbjct: 1346 QYEEETEAK----AELQRVLSKANSEVAQWRTKY--ETDAIQRTEEL-----EEAKKKLA 1394

Query: 371  EKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKD------ 424
            ++ +E    V+A   +           + E+E+ + D+E+         + +++      
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454

Query: 425  QYEEKLRASQMAEEITRKELQSVRLKL----QQQIVTIENAEKEKNENSDLKQQISSLQI 480
            ++++K   SQ   E ++KE +S+  +L         ++E+ E  K EN +L+++IS L  
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514

Query: 481  QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
            Q+ S  ++ ++L    + +++ +E  K E ++   +AE +    E  +   Q+++ + K 
Sbjct: 1515 QLGSSGKTIHEL----EKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570

Query: 541  KLHERITDREEKYNQAK-------EKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKE 593
            ++  ++ +++E+  QAK       + LQ +  A+ + +    N+  R+++K   +E    
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR----NEALRVKKK---MEGDLN 1623

Query: 594  ELETENQVLNRQNVPFEDYTR-LQKRLKDIQ 623
            E+E +    NR     +   + LQ  LKD Q
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654



 Score =  111 bits (278), Expect = 2e-24
 Identities = 157/725 (21%), Positives = 302/725 (41%), Gaps = 89/725 (12%)

Query: 24   LTGSQSEFQKMLIDERLRCEH---HKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQ 80
            L   +SEF+  L D     E     KAN + +        NEH     E +   N+  +Q
Sbjct: 1217 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ 1276

Query: 81   QEKLQLLLEELRGELVEKTKDLEEMKLQILT-PQKLELLRAQIQQELETP--MRERFRNL 137
            + KLQ    EL  +L EK   + ++    LT  Q+LE L+ Q+++E++    +    ++ 
Sbjct: 1277 RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336

Query: 138  DEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQ 197
              + +  R  Y     E T  K+E +    +    + + + KYE++  +  E+ EE + +
Sbjct: 1337 RHDCDLLREQYE----EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392

Query: 198  LLNVDLTKDSKRVEQLAREKVYLCQKLKG-LEAEVAELKAEKENSEAQ---VENAQRIQV 253
            L      ++++   +    K    +K K  L+ E+ +L  + E S A    ++  QR   
Sbjct: 1393 L--AQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450

Query: 254  RQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVK 313
            + LAE +      ++E +S+   A  L  EL          +  L   +RE   L  ++ 
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510

Query: 314  ELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQS-----DNEILKAAVEHHKVL 368
            +L          I  E  + + +LE E+ ++QS L+  ++     + +IL+A +E +++ 
Sbjct: 1511 DLTEQLGSSGKTIH-ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569

Query: 369  ------LVEKDREL-------IRKVQA----------AKEEGYQKLVVLQDEKLELENRL 405
                  L EKD E+       +R V +          ++ E  +    ++ +  E+E +L
Sbjct: 1570 AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629

Query: 406  ADLEKMKVEHDVWRQS-----------------EKDQYEEKLRASQMAEEITRKELQSVR 448
            +   +M  E     +S                   D  +E +   +    + + EL+ +R
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689

Query: 449  LKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQ 508
              ++Q   + + AE+E  E S+  Q + S   Q TSL   +  +      L+  VE   Q
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHS---QNTSLINQKKKMDADLSQLQTEVEEAVQ 1746

Query: 509  ECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK 568
            ECRN   +A+KA  +A    EE + +     H L     + E+     + +L  A     
Sbjct: 1747 ECRNAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNMEQTIKDLQHRLDEA----- 1800

Query: 569  KRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNV-PFEDYTRLQKRLKDIQRRHN 627
                  +  LK  +++++ LEA+  ELE E +   ++N    +   + ++R+K++  +  
Sbjct: 1801 -----EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE 1855

Query: 628  EFR-SLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
            E R +L+ + ++     +   +++  A              EEQ    LS  RK   EL+
Sbjct: 1856 EDRKNLLRLQDLVDKLQLKVKAYKRQA-----------EEAEEQANTNLSKFRKVQHELD 1904

Query: 687  TTQRK 691
              + +
Sbjct: 1905 EAEER 1909



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 126/553 (22%), Positives = 249/553 (45%), Gaps = 89/553 (16%)

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFL---KSEFEHQ-------- 165
            LL++  +++    M+E F  L E +EK  A   +L  +   L   K++ + Q        
Sbjct: 839  LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898

Query: 166  --KEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQK 223
               EE    L + KI+ E+++  + E  E+   + +N +LT   +++E    E   L + 
Sbjct: 899  ADAEERCDQLIKNKIQLEAKVKEMNERLED--EEEMNAELTAKKRKLEDECSE---LKRD 953

Query: 224  LKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
            +  LE  +A+++ EK  +E +V+N       ++A +   +  L  EK++     ++   +
Sbjct: 954  IDDLELTLAKVEKEKHATENKVKNL----TEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009

Query: 284  LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNK 343
            LQ+  ++   L     K E++++ L   +++ K         ++++  RAK +LE +   
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK--------KVRMDLERAKRKLEGDLKL 1061

Query: 344  IQSELDGLQSDNEILKAAVEHHKVLLVEKDREL------IRKVQAAKEEGYQKLVVLQ-- 395
             Q  +  L++D + L          L +KD EL      I   QA   +  +KL  LQ  
Sbjct: 1062 TQESIMDLENDKQQLDER-------LKKKDFELNALNARIEDEQALGSQLQKKLKELQAR 1114

Query: 396  ----DEKLELENRLADLEKMKVEHDVWRQSEK--DQYEEKLRASQMAEEITRK---ELQS 446
                +E+LE E R A  +  K+  D+ R+ E+  ++ EE   A+ +  E+ +K   E Q 
Sbjct: 1115 IEELEEELEAE-RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173

Query: 447  VRLKLQQQIVTIENA-----EKEKNENSDLKQQISSLQ--------------IQVTSLAQ 487
            +R  L++  +  E       +K  +  ++L +QI +LQ              +++  +  
Sbjct: 1174 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233

Query: 488  SENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEA-EKTLEEKQIQ--------WLEE 538
            +   ++ +   L++M   L+ +    RS+AE+ Q    + T +  ++Q         L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293

Query: 539  KHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETE 598
            K  L  ++T  +  Y Q  E L+R    + K K+   + L+  +   ++L  + EE ETE
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE-ETE 1352

Query: 599  -----NQVLNRQN 606
                  +VL++ N
Sbjct: 1353 AKAELQRVLSKAN 1365



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 142/642 (22%), Positives = 268/642 (41%), Gaps = 77/642 (11%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            L     E  + L DE        A  + L+ E + L+ +   L+  L  +  EK   + K
Sbjct: 915  LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974

Query: 84   LQLLLEELRG------ELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNL 137
            ++ L EE+ G      +L ++ K L+E   Q L   + E  +     + +  + ++  +L
Sbjct: 975  VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL 1034

Query: 138  DEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESE-IARLEEDKEELRN 196
            +  +E+ + V           + + E  K +      EG +K   E I  LE DK++L  
Sbjct: 1035 EGSLEQEKKV-----------RMDLERAKRKL-----EGDLKLTQESIMDLENDKQQLDE 1078

Query: 197  QLLNVD--LTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKE---NSEAQVENAQRI 251
            +L   D  L   + R+E        L +KLK L+A + EL+ E E    + A+VE  +  
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSD 1138

Query: 252  QVRQLAEMQ--------ATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAER 303
              R+L E+         AT   +E  K+      +++ ++L+ ++ Q+      L K   
Sbjct: 1139 LSRELEEISERLEEAGGATSVQIEMNKK-REAEFQKMRRDLEEATLQHEATAAALRKKHA 1197

Query: 304  E-INTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNE-ILKAA 361
            + +  L  ++  L+               R K +LE+E+++ + ELD + S+ E I+KA 
Sbjct: 1198 DSVAELGEQIDNLQ---------------RVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242

Query: 362  VEHHKVLLVEKD-----RELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHD 416
                K+    +D     R    + Q +  +   +   LQ E  EL  +L + E +  +  
Sbjct: 1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302

Query: 417  VWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTI--ENAEKEKNENSDLKQQ 474
              + +   Q E+  R  Q+ EE+  K   +  L+  +    +  E  E+E    ++L++ 
Sbjct: 1303 RGKLTYTQQLEDLKR--QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1360

Query: 475  ISSLQIQVTS-LAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQI 533
            +S    +V     + E D +   + L+E  ++L Q  +    +AE    EA + +  K  
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----EAE----EAVEAVNAKCS 1412

Query: 534  QWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKR---KSLHENKLKRLQEKVEVLEA 590
               + KH+L   I D     +  +     AA+ +K+R   K L E K K  + + E+  +
Sbjct: 1413 SLEKTKHRLQNEIEDL--MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS 1470

Query: 591  KKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSL 632
            +KE      ++   +N   E    L+   ++ +    E   L
Sbjct: 1471 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512



 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 128/559 (22%), Positives = 236/559 (42%), Gaps = 105/559 (18%)

Query: 136  NLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKE-EL 194
            +LD +  +Y+  + K+ ++   L    E + E  +RI+   + +    +AR+E  K  E 
Sbjct: 748  SLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLER 807

Query: 195  RNQLLNVD-----------------------LTKDSKRVEQLAREKVYLCQKLKGLEAEV 231
            R+ LL +                        L K ++R +++A  K    +  + LE   
Sbjct: 808  RDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSE 867

Query: 232  AELKA--EKENSEAQVENAQRIQVR----QLAEMQATVRSLEAEKQSANLRAERLEKELQ 285
            A  K   EK  S  Q +N  ++QV+     LA+ +     L   K     + + + + L+
Sbjct: 868  ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLE 927

Query: 286  SSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQ 345
               E N  L  K  K E E + L           K +I D++L  A+ + E     NK++
Sbjct: 928  DEEEMNAELTAKKRKLEDECSEL-----------KRDIDDLELTLAKVEKEKHATENKVK 976

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRL 405
            +  + +   +EI+ A +   K  L E  ++ +  +QA ++    K+  L   K++LE ++
Sbjct: 977  NLTEEMAGLDEII-AKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAKVKLEQQV 1031

Query: 406  ADLE-----KMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIEN 460
             DLE     + KV  D+ R   K + + KL    + +    K+    RLK +   +   N
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN 1091

Query: 461  A--EKEKNENSDLKQQISSLQIQVTSL---------AQSENDLLNSN--QMLKEMVERLK 507
            A  E E+   S L++++  LQ ++  L         A+++ + L S+  + L+E+ ERL+
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151

Query: 508  Q-----------------ECRNFRSQAEKAQLEAEKT---LEEKQIQWLEE--------- 538
            +                 E +  R   E+A L+ E T   L +K    + E         
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211

Query: 539  --KHKLHER----------ITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVE 586
              K KL +           +T   E+  +AK  L++     + + + H +K +  Q  V 
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271

Query: 587  VLEAKKEELETENQVLNRQ 605
             L +++ +L+TEN  L+RQ
Sbjct: 1272 DLTSQRAKLQTENGELSRQ 1290



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 108/483 (22%), Positives = 209/483 (43%), Gaps = 66/483 (13%)

Query: 22   SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQN----ELKHLFN-- 75
            + L   Q  F K+L + + + E  ++  ++ + E   L  E  KL+N     L+HL    
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499

Query: 76   -EKQTQQEKLQLLLEELRG--------ELVEKTKDLEEMKLQILTPQKLELLRAQIQQEL 126
             E +  QE++  L E+L          E V K  + E+M+LQ      LE   A ++ E 
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEE 1555

Query: 127  ETPMRER--FRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILD------EGKI 178
               +R +  F  +  E+E+  A  ++          E E  K  + R++D      + + 
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDE----------EMEQAKRNHLRVVDSLQTSLDAET 1605

Query: 179  KYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE-LKAE 237
            +  +E  R+++  E   N++  + L+  ++   +  ++   L   LK  + ++ + ++A 
Sbjct: 1606 RSRNEALRVKKKMEGDLNEM-EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1664

Query: 238  KENSE--AQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLI 295
             +  E  A VE    +   +L E++A V   E  ++ A        + +Q    QNT LI
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724

Query: 296  NKLHKAEREINTLSSKVKE-------LKHSNKLEITDIKLETARAKSELERERNKIQSEL 348
            N+  K + +++ L ++V+E        +   K  ITD     A    EL++E++   + L
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD----AAMMAEELKKEQD-TSAHL 1779

Query: 349  DGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADL 408
            + ++ + E     ++H           L    Q A + G ++L  L+    ELEN L   
Sbjct: 1780 ERMKKNMEQTIKDLQH----------RLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829

Query: 409  EKMKVEH-DVWRQSEKDQYEEKLRASQMAEEITRKE--LQSVRLKLQQQIVTIENAEKEK 465
            +K   E     R+SE+   E   +  +  + + R +  +  ++LK++      E AE++ 
Sbjct: 1830 QKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889

Query: 466  NEN 468
            N N
Sbjct: 1890 NTN 1892


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  116 bits (290), Expect = 8e-26
 Identities = 147/639 (23%), Positives = 295/639 (46%), Gaps = 84/639 (13%)

Query: 36   IDERLRCEHHKA----NYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----EKLQL 86
            IDE  R    K     N Q L+  HT+LQ E   L  E + L N K+  +      +L+L
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELEL 1310

Query: 87   LLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
            L E+        TKD         T  ++E+ R ++ ++ +   +E  ++L +E +  + 
Sbjct: 1311 LTEQ------STTKDST-------TLARIEMERLRLNEKFQES-QEEIKSLTKERDNLKT 1356

Query: 147  VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELR----------- 195
            +   L  +H  LK   EH +E  A+I  E + K E  +   E+D E  +           
Sbjct: 1357 IKEALEVKHDQLK---EHIRETLAKI-QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412

Query: 196  -NQLLNVDLTKD--SKRVEQ-------LAREKVYLCQKLKGLEAEVAELKAE-KENSEAQ 244
             + LL +++     SKR+++       +A+EK  L +  + L++E  +LK   KE     
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472

Query: 245  VENAQRIQVRQ--LAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAE 302
            +E  + ++V    L E + T+  L             ++K+L++ +++    I ++++ E
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532

Query: 303  -----REINTLSSKVKELKHSNK-LEITDIKLETARAKS-ELERERNKIQSELDGLQSDN 355
                 ++I+ +  KV ELK   +  +  D  L++  +K  EL     + Q E+  +  + 
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 356  EILKA---AVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMK 412
            E +K    A++  +  L E  +E++ K++ ++E+ YQ L +      E + ++ ++E +K
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN--ETQEKMCEIEHLK 1650

Query: 413  VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLK 472
             + +  + + ++   E +R +Q+  E   +E++SV  K +  + ++E  E  K E   LK
Sbjct: 1651 EQFETQKLNLENIETENIRLTQILHE-NLEEMRSVT-KERDDLRSVE--ETLKVERDQLK 1706

Query: 473  QQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQ------ECRNFRSQAEKAQLEAEK 526
            +   +L+  +T   + + +L   +  LKE  E + +      E  N  S  +K    +  
Sbjct: 1707 E---NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSND 1763

Query: 527  TLEEKQIQWLEEKHKLHERITDREEKYNQAK----EKLQRAAIAQKKRKSLHENKLKRLQ 582
             L+ + ++  EE    H  + +++E  ++ +    EK  + +  QK      EN   +LQ
Sbjct: 1764 ALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL----ENSNAKLQ 1819

Query: 583  EKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
            EK++ L+A + +L T  + +N       +  +L+K++KD
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 147/616 (23%), Positives = 272/616 (44%), Gaps = 78/616 (12%)

Query: 21   DSGLTGSQSEFQKMLID-ERLRCEHHKANYQ----------------TLKAEHTRLQNEH 63
            +S L   ++++  +++D E+LR E  +   +                T K +  +L +E 
Sbjct: 497  ESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEI 556

Query: 64   VKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQ 123
              L+N +KH     Q  + +L   +E LR E  ++ K L+E     +  QKLE ++  + 
Sbjct: 557  SNLKNLVKHAEVYNQDLENELSSKVELLR-EKEDQIKKLQE----YIDSQKLENIKMDLS 611

Query: 124  QELET---PMRERFRNLDEEVEKYRAVYNK--LRYEHTFLKSEFEHQKEEYARILDEGKI 178
              LE+   P + +    D E     A      LR E+  LK + +     Y ++ ++ ++
Sbjct: 612  YSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL 671

Query: 179  KYESEIARLEEDKEELRNQLLNV--DLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
             Y+S++   ++ + +L  +L +   ++TK +  ++     K  LC     LE ++ +L+ 
Sbjct: 672  -YQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-PKDLLCN--LELEGKITDLQK 727

Query: 237  EKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLIN 296
            E  N E +   A R +V  L+E+    +SL +E        ERL KE+Q  SE+   + +
Sbjct: 728  EL-NKEVEENEALREEVILLSEL----KSLPSE-------VERLRKEIQDKSEELHIITS 775

Query: 297  KLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNE 356
            +  K   E+    S+V+ L             E  + K +L   ++  +S     Q+   
Sbjct: 776  EKDKLFSEVVHKESRVQGLLE-----------EIGKTKDDLATTQSNYKSTDQEFQNFKT 824

Query: 357  ILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKL-VVLQDEKLELENRLADLEKMKVEH 415
            +     + +K++L E +R     V  +KE   QK    L   K EL  +  +L++ K   
Sbjct: 825  LHMDFEQKYKMVLEENERMNQEIVNLSKEA--QKFDSSLGALKTELSYKTQELQE-KTRE 881

Query: 416  DVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQI 475
               R +E +Q +E+L       +   +E   +  KLQQ   T+E  +    E  DLKQ  
Sbjct: 882  VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ---TLEEVKTLTQEKDDLKQLQ 938

Query: 476  SSLQIQVTSLAQSENDLLNSN----QMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
             SLQI+   L    +D +N N    + L+  +E LKQ      +   K   E  + L  +
Sbjct: 939  ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998

Query: 532  QIQWLEEKHKLHERITDREEKYNQAKEKLQRAA-------IAQKKRK--SLHENKLKRLQ 582
            +    E K +  +++   ++K +   +  Q          I +++RK  SL + K   LQ
Sbjct: 999  E-NTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK-NELQ 1056

Query: 583  EKVEVLEAKKEELETE 598
            + +E + A+KE+L+T+
Sbjct: 1057 QMLESVIAEKEQLKTD 1072



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 152/767 (19%), Positives = 330/767 (43%), Gaps = 163/767 (21%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEE----------LRGEL 95
            ++NY++   E    +  H+  + + K +  E +   +++  L +E          L+ EL
Sbjct: 809  QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868

Query: 96   VEKTKDLEEMKLQILTP-QKLELLRAQIQQE---LETPMRER-------------FRNLD 138
              KT++L+E   ++     ++E L+ Q++     L+T  RE+              + L 
Sbjct: 869  SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLT 928

Query: 139  EEVEKYRAVYNKLRYEHTFLKSEFE-----------------HQKEEYARILDEGKIKYE 181
            +E +  + +   L+ E   LKS+                      +++   ++  K K  
Sbjct: 929  QEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS 988

Query: 182  SEIAR---LEED----KEELRNQLLNVDL---------------TKDSKRVEQ------L 213
             E++R   +EE+    K+E + +++ +D                 KD++ +EQ      L
Sbjct: 989  EEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL 1048

Query: 214  AREKVYLCQKLKGLEAEVAELKAE-KENSEAQVENAQRIQV--RQLAEMQATVR------ 264
             +EK  L Q L+ + AE  +LK + KEN E  +EN + +++   +L + Q  V       
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108

Query: 265  -SLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKH-SNKLE 322
               E E      R   +E++L+  S+Q      +L   + E++ +  K+ E+++  N+L+
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168

Query: 323  ITDIKLETARA-KSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKD--RELIRK 379
              ++ LE     + EL ++ N+   E+  +  + ++LK   E  K    E+D  R  IR+
Sbjct: 1169 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK---ELQKSFETERDHLRGYIRE 1225

Query: 380  VQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLR--ASQMAE 437
            ++A                      L   E++K+ H +  +  ++  +E  R  + + A+
Sbjct: 1226 IEA--------------------TGLQTKEELKIAH-IHLKEHQETIDELRRSVSEKTAQ 1264

Query: 438  EITRKELQSVRLKLQQQIVTIENAE------KEKNENSDLKQQISSLQIQ-----VTSLA 486
             I  ++L+    KLQ++I  +   +      KE +E  +   ++  L  Q      T+LA
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324

Query: 487  QSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKAQLEAEKTLE--EKQIQWLEEKHK 541
            + E + L  N+  +E  E +K   +E  N ++  E  +++ ++  E   + +  ++E   
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384

Query: 542  LHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKL------KRLQEKVEVLEA---KK 592
              E+  + +EK N+  + +      + K  +L   ++      KRLQE  + +++   +K
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444

Query: 593  EELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPN---MPPTASINPVSF 649
            ++L+   +VL  ++       +L++ +K+I  +H E    + V +        +IN +  
Sbjct: 1445 DDLQRLQEVLQSES------DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              S                 + + E+S ++K+LE +    + +++E+
Sbjct: 1499 NLS-----------------EKETEISTIQKQLEAINDKLQNKIQEI 1528



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 146/706 (20%), Positives = 294/706 (41%), Gaps = 109/706 (15%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTP 112
            + E      E V L +ELK L +E +  ++++Q   EEL     EK K   E+  +    
Sbjct: 732  EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRV 791

Query: 113  QKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI 172
            Q L     + + +L T  +  +++ D+E + ++ ++     ++  +  E E   +E   +
Sbjct: 792  QGLLEEIGKTKDDLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL 850

Query: 173  LDEGKIKYESEIARLE---------------------EDKEELRNQLLNVDLTKDSKRVE 211
              E + K++S +  L+                      + E+L+ QL N D T     ++
Sbjct: 851  SKEAQ-KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDST-----LQ 904

Query: 212  QLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQ---------------------- 249
             + REK  + +KL+    EV  L  EK++ +   E+ Q                      
Sbjct: 905  TVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQE 964

Query: 250  --RIQVRQLAEMQATVRSLEA---EKQSANLRAERLEKELQSSSEQNTFLINKLHKAE-R 303
              R  +  L + Q T+ +L++   E+ S NL  E    E +   +Q    I+K    E +
Sbjct: 965  QLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAK 1024

Query: 304  EINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE 363
               TL++ VK+    N++      +E  R    L +E+N++Q  L+ + ++ E LK  ++
Sbjct: 1025 NTQTLTADVKD----NEI------IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074

Query: 364  HHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEK 423
             +  + +E   EL       K+   Q+ +V Q++             +K E ++ R  ++
Sbjct: 1075 ENIEMTIENQEELRLLGDELKK---QQEIVAQEKN----------HAIKKEGELSRTCDR 1121

Query: 424  -DQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQV 482
              + EEKL+      +  +++L +V+ ++ +    I   E  KNE  + +  +  ++ + 
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181

Query: 483  TSLAQSEND-------LLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQW 535
              LAQ  N+       +    ++LKE+ +  + E  + R    + +    +T EE +I  
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241

Query: 536  LEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEEL 595
            +  K    E I +     ++   ++      +K    L E ++  L E+ E+L   KE  
Sbjct: 1242 IHLKEH-QETIDELRRSVSEKTAQIINTQDLEKSHTKLQE-EIPVLHEEQELLPNVKEVS 1299

Query: 596  ET-----ENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQ 650
            ET     E ++L  Q+   +D T L +   +  R + +F+             I  ++ +
Sbjct: 1300 ETQETMNELELLTEQSTT-KDSTTLARIEMERLRLNEKFQE--------SQEEIKSLTKE 1350

Query: 651  SSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
               +    E     H Q ++H      +R+ L +++ +Q KQ + L
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEH------IRETLAKIQESQSKQEQSL 1390



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 157/699 (22%), Positives = 279/699 (39%), Gaps = 138/699 (19%)

Query: 32   QKMLIDERLRCEHH--KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL-- 87
            Q + I E LR  H   K   +T+      +  +  KL N  K L N     QEK+Q L  
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA 1827

Query: 88   -------LEELRGELVEKTKDLEEMKLQI----LTPQKLELLRAQIQQELETPMRERFRN 136
                   L++   E  +K  ++E++K QI    LT  KLE+    + Q+L   + E  ++
Sbjct: 1828 NEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE-MKS 1886

Query: 137  LDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARL--EEDKEEL 194
            + +E +  R V   L+ E   LK   +  K   AR L+   I+ E + AR+  +E KE  
Sbjct: 1887 VMKERDNLRRVEETLKLERDQLKESLQETK---ARDLE---IQQELKTARMLSKEHKE-- 1938

Query: 195  RNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVR 254
                     T D  R E+++ + + +    K L+    EL  +K+  E Q +  Q ++V+
Sbjct: 1939 ---------TVDKLR-EKISEKTIQISDIQKDLDKSKDEL--QKKIQELQKKELQLLRVK 1986

Query: 255  QLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKE 314
            +   M    +  E E+      A+ L   +QS    N  L  KLH++  EI  ++ +  E
Sbjct: 1987 EDVNMSHK-KINEMEQLKKQFEAQNLS--MQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043

Query: 315  L---KHSNKLEITDIKLETARAKSELERERNKIQSEL----DGLQSDNEILKAAVEHHKV 367
            L   K S K+E  D  + T R     +R+ ++++ E     DG Q   E L+      K 
Sbjct: 2044 LRRIKESLKME-RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE 2102

Query: 368  LL-----------------------VEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENR 404
            LL                       +E  +EL  +V+A     Y  L     EKL   N+
Sbjct: 2103 LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPY--LQTKHIEKLFTANQ 2160

Query: 405  LADLE----------------KMKVE-HDVWRQSEKDQYEE---------KLRASQMAEE 438
               +E                K+K E H+   + E D  +E         K++  Q   +
Sbjct: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD 2220

Query: 439  ITRKELQSVRLKLQQQIVTIENAEKEKNENS--DLKQQISSLQIQVTSLAQSENDLLNSN 496
            +  +EL+ ++L  Q   + IE   K+ +E+    +K +   +      + Q   + LN+ 
Sbjct: 2221 VPSRELRDLKLN-QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR 2279

Query: 497  QMLKEMVERLKQE------CRNFRSQAEKAQLEAEKTLEEKQI----QWLEEKHKLHERI 546
              ++++   +++E        NF +    A +      EE+      +W ++   L E+ 
Sbjct: 2280 FDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN 2339

Query: 547  TDREEKYNQAKEKLQRAA---------------------IAQKKRK---SLHENKLKRLQ 582
                + Y   K  L   A                       +K R+   SLHE K   + 
Sbjct: 2340 EKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMH 2399

Query: 583  EKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
            ++ ++++ +K ELE  N ++ +      +  +  ++ K+
Sbjct: 2400 KESKIIKMQK-ELEVTNDIIAKLQAKVHESNKCLEKTKE 2437



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 142/729 (19%), Positives = 307/729 (42%), Gaps = 102/729 (13%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQ----QEKLQ 85
            E Q+ L    +  + H+     L+   +   NE   +Q +L+H  +  + Q    QE+L+
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 86   L----------LLEELRGELVEKT-------KDLEEMKLQILTPQKLELLRAQIQQEL-- 126
            +           +++LRG + EKT       KDLE    ++   +K++ L+A   Q +  
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--QEKIQELKANEHQLITL 1835

Query: 127  -----ETPMR-ERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDE-GKIK 179
                 ET  +      L ++++      +KL  E+  L  +     EE   ++ E   ++
Sbjct: 1836 KKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR 1895

Query: 180  YESEIARLEED--KEELR-NQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
               E  +LE D  KE L+  +  ++++ ++ K    L++E      KL+    +++E   
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR---EKISEKTI 1952

Query: 237  EKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANL------RAERLEKE------- 283
            +  + +  ++ ++    +++ E+Q     L   K+  N+        E+L+K+       
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012

Query: 284  LQSSSEQNTFLINKLHKAEREINTLS---SKVKELKHSNKLEITDIKLETARAKSELERE 340
            +QS    N  L  KLH++  EI  ++    +++ +K S K+E  D  + T R     +R+
Sbjct: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME-RDQFIATLREMIARDRQ 2071

Query: 341  RNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLE 400
             ++++ E         +L    +H    L E  RE   +++   +  Y ++    D+  E
Sbjct: 2072 NHQVKPE-------KRLLSDGQQH----LTESLREKCSRIKELLKR-YSEM----DDHYE 2115

Query: 401  LENRLA-DLEK---------MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLK 450
              NRL+ DLEK         M+V+ ++     + ++ EKL     A +    E   +  K
Sbjct: 2116 CLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFT---ANQRCSMEFHRIMKK 2172

Query: 451  LQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQEC 510
            L+  +  +   ++E++E+      I+  ++      + + +LL   Q L++  +   +E 
Sbjct: 2173 LKYVLSYVTKIKEEQHES------INKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSREL 2226

Query: 511  RNFRSQAEKAQLEAEKTLEE-KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKK 569
            R+ +   +   L  E+ L++  + ++   K +  + +++R+E     +E L      +K 
Sbjct: 2227 RDLKLN-QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKL 2285

Query: 570  RKSLHENKLKRLQE----KVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRR 625
            +  + +   +  Q        ++    E  E E +         +D   L+++ + + + 
Sbjct: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345

Query: 626  HNEFR-SLILVPNMPPTASINP---VSFQSSAMVPS--MELPFPPHMQEEQHQRELSLLR 679
            +   + SL     + PT   N    V+ +++ +      EL    H  +E    + S + 
Sbjct: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405

Query: 680  KRLEELETT 688
            K  +ELE T
Sbjct: 2406 KMQKELEVT 2414



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 122/547 (22%), Positives = 238/547 (43%), Gaps = 84/547 (15%)

Query: 59   LQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQI--------- 109
            LQ +H++       LF   Q    +   ++++L+  L   TK  EE    I         
Sbjct: 2147 LQTKHIE------KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID 2200

Query: 110  -LTPQKLELLRAQ-IQQELETPMRERF-----RNLDEEVEKYRAVYNKLRYEHTFLKSEF 162
             +  QK  L++ Q +QQ+ + P RE       +N+D  +E+    +++  +    +K+EF
Sbjct: 2201 EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPS--IKTEF 2258

Query: 163  EH---QKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVY 219
            +     ++E  + L+E  +    +I +L+   ++  +++  V+    + R+  +  E   
Sbjct: 2259 QQVLSNRKEMTQFLEEW-LNTRFDIEKLKNGIQKENDRICQVN-NFFNNRIIAIMNESTE 2316

Query: 220  LCQKLKGLEAE-VAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE 278
              ++   +  E   +LK+ KE +E   +N Q ++    +  Q    + + +      RA 
Sbjct: 2317 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT 2376

Query: 279  RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSE-- 336
            +L      ++E+   L N LH+A+       SK+  +K   +LE+T+  +   +AK    
Sbjct: 2377 QL------TTEKIRELENSLHEAKESAMHKESKI--IKMQKELEVTNDIIAKLQAKVHES 2428

Query: 337  ---LERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVV 393
               LE+ +  IQ   D +    +  K  +E  K+ LV+ D E   K++ AKE  ++K + 
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLE---KMKNAKE--FEKEIS 2483

Query: 394  LQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEIT----RKELQSVRL 449
                 +E +  +  L +                 E LR SQ A++ +      + Q    
Sbjct: 2484 ATKATVEYQKEVIRLLR-----------------ENLRRSQQAQDTSVISEHTDPQPSNK 2526

Query: 450  KLQ----QQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
             L       IV    A   K+E+  L+++IS L+ Q   L + +N+LL++NQ L   V+ 
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKT 2586

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
             K+  R  + +A K Q+  E + +  ++     K K   +IT      +Q KE+  +  +
Sbjct: 2587 WKE--RTLKREAHK-QVTCENSPKSPKVTGTASKKK---QITP-----SQCKERNLQDPV 2635

Query: 566  AQKKRKS 572
             ++  KS
Sbjct: 2636 PKESPKS 2642



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 125/614 (20%), Positives = 250/614 (40%), Gaps = 105/614 (17%)

Query: 36   IDERLRCEHH--KANYQTLKAEHTRLQNE----------HVKLQNELKHLFNEKQTQQEK 83
            ++E L+ E    K + Q  KA    +Q E          H +  ++L+   +EK  Q   
Sbjct: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEK 143
            +Q  L++ + EL +K ++L++ +LQ        LLR +    +          L ++ E 
Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKELQ--------LLRVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 144  YRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDL 203
                   +R ++  L  +  H+  E  RI+     K   E+ R++E  +  R+Q +    
Sbjct: 2009 QNLSMQSVRMDNFQLTKKL-HESLEEIRIV----AKERDELRRIKESLKMERDQFI---- 2059

Query: 204  TKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEK---ENSEAQVENAQRIQVRQLAEMQ 260
               +   E +AR++            +  ++K EK    + +  +  + R +  ++ E+ 
Sbjct: 2060 ---ATLREMIARDR------------QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104

Query: 261  ATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNK 320
                 ++   +  N  +  LEKE++   E +           R    LS    + KH  K
Sbjct: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSM----------RVKANLSLPYLQTKHIEK 2154

Query: 321  LEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLL---VEKDRELI 377
            L   +      R   E  R   K++  L  +    E    ++   ++     VEK +EL+
Sbjct: 2155 LFTAN-----QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209

Query: 378  RKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKL----RAS 433
             K+Q  +++       L+D KL     L   E +K   +    S K ++++ L      +
Sbjct: 2210 IKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMT 2269

Query: 434  QMAEE--ITRKELQSVRLKLQQQ---IVTIENAEKEK-----NENSDLKQQISSL----Q 479
            Q  EE   TR +++ ++  +Q++   I  + N    +     NE+++ +++ +++    +
Sbjct: 2270 QFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWE 2329

Query: 480  IQVTSLAQSENDLLNSNQMLK------EMVERLKQECRNFRSQAEKAQLEAEKTLEEKQI 533
              + SL +    L  + Q LK        V    Q+ +N    +   QL  EK  E +  
Sbjct: 2330 QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELE-- 2387

Query: 534  QWLEEKHKLHERITDREEKYNQAKEKLQ-RAAIAQKKRKSLHENK--LKRLQEKVEVLEA 590
                  H+  E    +E K  + +++L+    I  K +  +HE+   L++ +E ++VL+ 
Sbjct: 2388 ---NSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2444

Query: 591  K--------KEELE 596
            K        KEE+E
Sbjct: 2445 KVALGAKPYKEEIE 2458



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 54/251 (21%), Positives = 111/251 (44%), Gaps = 43/251 (17%)

Query: 395 QDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQ 454
           Q E++ LE R   +EK ++   +    EKD  ++    ++  E +TR  + S  L LQQ+
Sbjct: 358 QLEEVSLETRAQAMEKDQLAQLL---EEKDLLQKV--QNEKIENLTRMLVTSSSLTLQQE 412

Query: 455 I-------VTIENAEKEKNENSDLKQQIS--------------SLQIQVTSLAQSENDLL 493
           +       VT    +  K +NS+   Q +              +L  ++     SE+D+ 
Sbjct: 413 LKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVF 472

Query: 494 -NSNQMLKEM----------VERLKQECRNFRSQAEKAQLEAE--KTLEEKQIQWLEEKH 540
            N+   L E+           E ++ E  + R+  +   L+ E  +T +E+    L+EK+
Sbjct: 473 SNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKN 532

Query: 541 KLHE-RITDREEKYNQAKEKLQRAAIAQ---KKRKSLHENKLKRLQEKVEVLEAKKEELE 596
            L E    +R+ K +Q  + +   +  +   K  +  +++    L  KVE+L  K+++++
Sbjct: 533 DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIK 592

Query: 597 TENQVLNRQNV 607
              + ++ Q +
Sbjct: 593 KLQEYIDSQKL 603



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 27/95 (28%), Positives = 47/95 (49%), Gaps = 5/95 (5%)

Query: 52   LKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQIL- 110
            LK+EH RL+ E  KL+ + + L  +K       Q L  E++    E+T   E  K Q+  
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK-TWKERTLKREAHK-QVTC 2602

Query: 111  --TPQKLELLRAQIQQELETPMRERFRNLDEEVEK 143
              +P+  ++     +++  TP + + RNL + V K
Sbjct: 2603 ENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPK 2637


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  115 bits (287), Expect = 2e-25
 Identities = 138/626 (22%), Positives = 278/626 (44%), Gaps = 73/626 (11%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
            E  K  +DE+L  +  + +    K E    Q   ++LQ ++K L       Q +++ L E
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDE--QAVEIQLQKKIKEL-------QARIEELGE 1123

Query: 90   ELRGELVEKTK----------DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE 139
            E+  E   + K          +LEE+  ++         + ++ ++ E   ++  R+L+E
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE 1183

Query: 140  EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLL 199
               ++ A+   LR +H    +E   Q +   R+    K K E E + L+ + ++L     
Sbjct: 1184 ATLQHEAMVAALRKKHADSMAELGEQIDNLQRV----KQKLEKEKSELKMETDDL----- 1234

Query: 200  NVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVEN--AQRIQV---- 253
                   S   E +++ K  L +  + LE +V+ELK ++E  +  + +  AQR ++    
Sbjct: 1235 -------SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEA 1287

Query: 254  ----RQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLS 309
                RQL E  A V  L   KQ++  + E L+ +L+  ++    L + L  +  + + L 
Sbjct: 1288 GEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLR 1347

Query: 310  SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE-HHKVL 368
             + +E +        +++   ++A SE+ + R K   E D +Q   E+ +A  +   ++ 
Sbjct: 1348 EQYEEEQEGK----AELQRALSKANSEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQ 1401

Query: 369  LVEKDRELIRKVQAAKEEGYQKLV-VLQDEKLELEN---RLADLEKMKVEHDVWRQSEKD 424
              E+  E +    A+ E+  Q+L   ++D  L++E      A L+K +   D      K 
Sbjct: 1402 EAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQ 1461

Query: 425  QYEE---KLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQ 481
            +YEE   +L ASQ        EL  V+   ++   +++  E  + EN +L+Q+IS L  Q
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVYEE---SLDQLETLRRENKNLQQEISDLTEQ 1518

Query: 482  VTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK 541
            +    +  ++L    + +K+ VE+ K E +    +AE +    E  +   Q++  + K +
Sbjct: 1519 IAEGGKQIHEL----EKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSE 1574

Query: 542  LHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQV 601
            +  +I +++E+ +Q K    R     +  +S  + +++   + + V +  + +L      
Sbjct: 1575 VDRKIAEKDEEIDQLKRNHTRVV---ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQ 1631

Query: 602  LNRQN----VPFEDYTRLQKRLKDIQ 623
            LN  N        +Y   Q  LK+ Q
Sbjct: 1632 LNHANRLAAESLRNYRNTQGILKETQ 1657



 Score =  112 bits (279), Expect = 2e-24
 Identities = 156/698 (22%), Positives = 312/698 (44%), Gaps = 82/698 (11%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            ++ E Q+ LI++       +A  QT   E++R  +E   L ++L     +  TQQ     
Sbjct: 1264 TKEEEQQRLINDLTA---QRARLQTEAGEYSRQLDEKDALVSQLSRS-KQASTQQ----- 1314

Query: 87   LLEELRGELVEKTKDLEEMKLQILTPQK-LELLRAQIQQELE--TPMRERFRNLDEEVEK 143
             +EEL+ +L E+TK    +   + + +   +LLR Q ++E E    ++      + EV +
Sbjct: 1315 -IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373

Query: 144  YRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYES---EIARLEEDKEELRNQLLN 200
            +R  Y     + T    E E  K++ A+ L E +   E+   + A LE+ K+ L+N++ +
Sbjct: 1374 WRTKYETDAIQRT---EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430

Query: 201  VDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQ 260
            + L  +       A +K     K +  +  ++E K + E ++A++E +Q+ + R L+   
Sbjct: 1431 LMLDVERSNAACAALDK-----KQRNFDKVLSEWKQKYEETQAELEASQK-ESRSLSTEL 1484

Query: 261  ATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNK 320
              V+++  E      + E L +E ++  ++ + L  ++ +  ++I+ L  K+K+     K
Sbjct: 1485 FKVKNVYEESLD---QLETLRRENKNLQQEISDLTEQIAEGGKQIHELE-KIKKQVEQEK 1540

Query: 321  LEITDIKLETARAKSELER--------ERNKIQSELDG--LQSDNEILKAAVEHHKVLLV 370
             EI    LE A A  E E         E N+++SE+D    + D EI +    H +V  V
Sbjct: 1541 CEI-QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRV--V 1597

Query: 371  EKDRELIRKVQAAKEEGYQKLVVLQDEKLELE------NRLA--DLEKMKVEHDVWRQSE 422
            E  +  +     ++ +  +    ++ +  E+E      NRLA   L   +    + ++++
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657

Query: 423  KDQYEEKLRASQMAEE---ITRKELQSVRLKLQQQIVTIENAEKEKN----ENSDLKQQI 475
                ++ LR  +  +E   I  +    ++ ++++   T+E  E+ +     E  D  +++
Sbjct: 1658 L-HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERV 1716

Query: 476  SSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQW 535
              L  Q TSL  ++  L N    L+  VE + QE RN   +A+KA  +A    EE     
Sbjct: 1717 QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEE----- 1771

Query: 536  LEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEEL 595
            L+++      +   ++   Q  + LQ       +     +  LK  +++++ LEA+  EL
Sbjct: 1772 LKKEQDTSAHLERMKKNLEQTVKDLQH------RLDEAEQLALKGGKKQIQKLEARVREL 1825

Query: 596  ETENQVLNRQNVP-FEDYTRLQKRLKDIQRRHNEFRSLIL-VPNMPPTASINPVSFQSSA 653
            E E +   ++N    +   + ++R+K++  +  E R  +L + ++         S++  A
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885

Query: 654  MVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
                          EEQ    LS  RK   ELE  + +
Sbjct: 1886 -----------EEAEEQSNANLSKFRKLQHELEEAEER 1912



 Score =  103 bits (258), Expect = 4e-22
 Identities = 136/595 (22%), Positives = 271/595 (45%), Gaps = 58/595 (9%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K  +Q  K E  + + +  +L+ ++  L  EK   Q ++Q   + L  +  E+ + L + 
Sbjct: 856  KEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL-ADAEERCEQLIKN 914

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFE-H 164
            K+Q+    K    RA+ ++E+   +  + R L++E  + +   + L  E T  K E E H
Sbjct: 915  KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL--ELTLAKVEKEKH 972

Query: 165  QKEEYARILDEGKIKYESEIARLEEDKEELR--NQLLNVDLTKDSKRVEQLAREKVYLCQ 222
              E   + L E     +  IA+L ++K+ L+  +Q    DL  +  +V  L + K  L Q
Sbjct: 973  ATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQ 1032

Query: 223  KLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEK 282
            ++  LE  +     +++     +E A+R     L   Q +   +E +KQ  + + E+ E 
Sbjct: 1033 QVDDLEGSL----EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF 1088

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARA-KSELERER 341
            E+ +       LI+K+   +     L  K+KEL+   ++E    ++E  RA +++ E++R
Sbjct: 1089 EISN-------LISKIEDEQAVEIQLQKKIKELQ--ARIEELGEEIEAERASRAKAEKQR 1139

Query: 342  NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE---LIRKVQAAKEEGYQKLVVLQ--- 395
            + +  EL+ +    E    A      L  +++ E   L R ++ A  +    +  L+   
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH 1199

Query: 396  -DEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRA---SQMAEEITRKE--LQSVRL 449
             D   EL  ++ +L+++K      ++ EK++ E K+     S  AE I++ +  L+ +  
Sbjct: 1200 ADSMAELGEQIDNLQRVK------QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253

Query: 450  KLQQQIVTIENAEKEKNE-NSDLKQQISSLQIQVTSLAQ--SENDLL---------NSNQ 497
             L+ Q+  ++  E+E+    +DL  Q + LQ +    ++   E D L          S Q
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ 1313

Query: 498  MLKEMVERLKQE--CRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ 555
             ++E+  +L++E   +N  + A ++       L E+  +  E K +L   ++    +  Q
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373

Query: 556  AKEK-----LQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQ 605
             + K     +QR    ++ +K L + +L+  +E VE + AK   LE   Q L  +
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQ-RLQEAEEHVEAVNAKCASLEKTKQRLQNE 1427



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 113/537 (21%), Positives = 247/537 (45%), Gaps = 66/537 (12%)

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEH-TFLKSEFEHQ---------- 165
            L  A+ ++E+ T M+E F+   +E+ K  A   +L  +  T LK + + Q          
Sbjct: 843  LKSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901

Query: 166  --KEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQK 223
               EE    L + KI+ E++I  + E  EE   + +N +LT   +++E    E   L + 
Sbjct: 902  ADAEERCEQLIKNKIQLEAKIKEVTERAEE--EEEINAELTAKKRKLEDECSE---LKKD 956

Query: 224  LKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
            +  LE  +A+++ EK  +E +V+N       ++A +  T+  L  EK++     ++   +
Sbjct: 957  IDDLELTLAKVEKEKHATENKVKNL----TEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012

Query: 284  LQSSSEQNTFLINKLHKAEREINTLSSKVKELKH--------SNKLEITDIKLETARAKS 335
            LQ+  ++   L     K E++++ L   +++ K           KLE  D+KL    +  
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-GDLKL-AQESTM 1070

Query: 336  ELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQ 395
            ++E ++ ++  +L+  + +   L + +E  + + ++  ++ I+++QA  EE  +++   +
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKK-IKELQARIEELGEEIEAER 1129

Query: 396  DEKLELENRLADLEK-----------------MKVEHDVWRQSE-----KDQYEEKLRAS 433
              + + E + +DL +                  +VE +  R++E     +D  E  L+  
Sbjct: 1130 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189

Query: 434  QMAEEITRKELQSVRLKLQQQIVTIENA-EKEKNENSDLKQQISSLQIQVTSLAQSENDL 492
             M   + +K   S+  +L +QI  ++   +K + E S+LK +   L     ++++++ +L
Sbjct: 1190 AMVAALRKKHADSM-AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNL 1248

Query: 493  LNSNQMLKEMVERLKQECRNFRS-----QAEKAQLEAEKTLEEKQIQWLEEKHKLHERIT 547
                + L++ V  LK +    +       A++A+L+ E     +Q   L+EK  L  +++
Sbjct: 1249 EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ---LDEKDALVSQLS 1305

Query: 548  DREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNR 604
              ++   Q  E+L+     + K K+   + L+  +   ++L  + EE +     L R
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1362



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 127/608 (20%), Positives = 263/608 (43%), Gaps = 55/608 (9%)

Query: 47   ANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRG------ELVEKTK 100
            A  + L+ E + L+ +   L+  L  +  EK   + K++ L EE+ G      +L ++ K
Sbjct: 941  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKK 1000

Query: 101  DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKS 160
             L+E   Q L   + E  +  I  + +T + ++  +L+  +E+ +    KLR +    K 
Sbjct: 1001 ALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEK----KLRMDLERAKR 1056

Query: 161  EFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYL 220
            + E       ++  E  +  E++  +L+E  E+   ++ N+       ++E     ++ L
Sbjct: 1057 KLEGD----LKLAQESTMDMENDKQQLDEKLEKKEFEISNL-----ISKIEDEQAVEIQL 1107

Query: 221  CQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERL 280
             +K+K L+A + EL  E E   A    A++ +     E++     LE    + + + E L
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE-L 1166

Query: 281  EKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERE 340
             K+ ++  ++   L   L +A  +   + + +++    +  E+ +      R K +LE+E
Sbjct: 1167 NKKREAEFQK---LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE 1223

Query: 341  RNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQ--AAKEEGYQKLV------ 392
            +++++ E D L S+ E    A+   K  L +  R L  +V     KEE  Q+L+      
Sbjct: 1224 KSELKMETDDLSSNAE----AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279

Query: 393  --VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLK 450
               LQ E  E   +L + + +  +    +Q+   Q EE     Q+ EE   K   +  L+
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE--LKHQLEEETKAKNALAHALQ 1337

Query: 451  LQQQIVTI--ENAEKEKNENSDLKQQISSLQIQVTS-LAQSENDLLNSNQMLKEMVERLK 507
              +    +  E  E+E+   ++L++ +S    +V     + E D +   + L+E  ++L 
Sbjct: 1338 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1397

Query: 508  QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQ 567
            Q  +      E    +     + KQ      ++++ + + D E      +     AA+ +
Sbjct: 1398 QRLQEAEEHVEAVNAKCASLEKTKQ----RLQNEVEDLMLDVE------RSNAACAALDK 1447

Query: 568  KKR---KSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQR 624
            K+R   K L E K K  + + E+  ++KE      ++   +NV  E   +L+   ++ + 
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507

Query: 625  RHNEFRSL 632
               E   L
Sbjct: 1508 LQQEISDL 1515



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 104/483 (21%), Positives = 209/483 (43%), Gaps = 66/483 (13%)

Query: 22   SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQ 81
            + L   Q  F K+L + + + E  +A  +  + E   L  E  K++N    ++ E   Q 
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN----VYEESLDQL 1498

Query: 82   EKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQE---LETPMRERFRNLD 138
            E L+   + L+ E+ + T+ + E   QI    +LE ++ Q++QE   ++  + E   +L+
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQI---HELEKIKKQVEQEKCEIQAALEEAEASLE 1555

Query: 139  EEVEKYRAVYNKLRYEHTFLK-------SEFEHQKEEYARILDEGKIKYESEIA------ 185
             E  K   +  +L    + +         E +  K  + R+++  +   ++EI       
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL 1615

Query: 186  ----RLEEDKEELRNQL-----LNVDLTKDSKRVEQLARE-KVYLCQKLKGLEAEVAELK 235
                ++E D  E+  QL     L  +  ++ +  + + +E +++L   L+G E    +LK
Sbjct: 1616 RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE----DLK 1671

Query: 236  AEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLI 295
             +     A VE    +   ++ E+ AT+   E  ++ A        + +Q    QNT LI
Sbjct: 1672 EQL----AIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727

Query: 296  NKLHKAEREINTLSSKVKEL-------KHSNKLEITDIKLETARAKSELERERNKIQSEL 348
            N   K E +++ L S+V+E+       +   K  ITD     A    EL++E++   + L
Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITD----AAMMAEELKKEQD-TSAHL 1782

Query: 349  DGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADL 408
            + ++ + E     ++H           L    Q A + G +++  L+    ELE  + + 
Sbjct: 1783 ERMKKNLEQTVKDLQH----------RLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832

Query: 409  EKMKVEH-DVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNE 467
            +K   E     R+ E+   E   +  +  + + R  LQ +  KLQ ++ + +   +E  E
Sbjct: 1833 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLR--LQDLVDKLQAKVKSYKRQAEEAEE 1890

Query: 468  NSD 470
             S+
Sbjct: 1891 QSN 1893



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/132 (24%), Positives = 67/132 (50%), Gaps = 12/132 (9%)

Query: 492 LLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREE 551
           LL S +  KEM   +K+E +  + +  K++ +  K LEEK +  L+EK+ L  ++    +
Sbjct: 842 LLKSAETEKEMAT-MKEEFQKTKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQSEAD 899

Query: 552 KYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFED 611
               A+E+ ++          L +NK++   +  EV E  +EE E   ++  ++    ++
Sbjct: 900 SLADAEERCEQ----------LIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDE 949

Query: 612 YTRLQKRLKDIQ 623
            + L+K + D++
Sbjct: 950 CSELKKDIDDLE 961



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 45/238 (18%), Positives = 95/238 (39%), Gaps = 42/238 (17%)

Query: 496  NQMLKEMVERLKQECRNFRSQAEKA------------QLEAEKTLEEKQIQWLEEKHKLH 543
            ++ L +++ R +  CR F  + E              Q      +  K   W++   K+ 
Sbjct: 781  DEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIK 840

Query: 544  ERITDREEKYNQA--KEKLQRA----AIAQKKRKSLHENKLKRLQEKVEVLEAKKEELET 597
              +   E +   A  KE+ Q+     A ++ KRK L E  +  L+EK ++    + E ++
Sbjct: 841  PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADS 900

Query: 598  ENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAM--- 654
                  R     ++  +L+ ++K++  R  E   +    N   TA    +  + S +   
Sbjct: 901  LADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEI----NAELTAKKRKLEDECSELKKD 956

Query: 655  VPSMELPFPPHMQEEQHQRE----------------LSLLRKRLEELETTQRKQLEEL 696
            +  +EL     +++E+H  E                ++ L K  + L+ T ++ L++L
Sbjct: 957  IDDLELTL-AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  114 bits (286), Expect = 2e-25
 Identities = 148/695 (21%), Positives = 301/695 (43%), Gaps = 60/695 (8%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQI 109
            QTL ++ + L  +   LQ +L+ L  + Q     L L   EL  ++ +  K+ E +  + 
Sbjct: 2017 QTLSSDVSELLKDKTHLQEKLQSLEKDSQA----LSLTKCELENQIAQLNKEKELLVKES 2072

Query: 110  LTPQ----KLELLRAQIQQELETPMRE------RFRNLDEEVEKYRAVYNKLRYEHTFLK 159
             + Q    + +  +  + + LE  + E      R  +  EEV + R    KLR      +
Sbjct: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132

Query: 160  SEFEHQKEEYA-RILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKV 218
             +  H  E+   R  +   +K + E    E    E   +L+ +D       VE L  +  
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE 2192

Query: 219  YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLR-- 276
             + + LK  E ++  L++EKEN   Q++  Q  Q+ +L ++ ++ +SL  EK+ A ++  
Sbjct: 2193 EMARSLKVFELDLVTLRSEKENLTKQIQEKQG-QLSELDKLLSSFKSLLEEKEQAEIQIK 2251

Query: 277  ------AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS--NKLEITDIKL 328
                   E L+ +L+  +E    L       +    +L   ++E +H   N +E    +L
Sbjct: 2252 EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE-EHQLRNSIEKLRARL 2310

Query: 329  ETARAKS--------ELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKV 380
            E    K         E E   + ++  ++ L+ + EI +   EH   L  E  +  +  +
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH-AALEAENSKGEVETL 2369

Query: 381  QAAKEEGYQKL-------VVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRAS 433
            +A  E   Q L       V ++ EK  L N L   ++   E ++   S ++  +EK +  
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429

Query: 434  -QMAEEI-TRKELQSVRLK-LQQQIVTIENAEKE-KNENSDLKQQISSLQIQVTSLAQSE 489
             QM E+  T  E+   +LK L +++  + N ++  K +  +L  Q+  L+++   L Q  
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 490  NDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDR 549
            ++  N+  +L+  V  L QE  + + + EK   E  +   + QIQ  E+      ++   
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRL--KNQIQDQEQLVSKLSQVEGE 2547

Query: 550  EEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
             + + +   +L+   +  +++  + ++K   LQ+ +EVL++  + LE E ++     + F
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607

Query: 610  -EDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASI-NPVSFQSSAMVPSMELPFPPHMQ 667
             E   ++  +  ++QR  +E            TA +   +S + + +   ++L       
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQ--------KTAELQEELSGEKNRLAGELQLLLEEIKS 2659

Query: 668  EEQHQRELSLLRKRLEE-LETTQRKQLEELGSSGE 701
             +   +EL+L    L++ L+   + Q+E+ G   E
Sbjct: 2660 SKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE 2694



 Score =  111 bits (278), Expect = 2e-24
 Identities = 165/725 (22%), Positives = 323/725 (44%), Gaps = 85/725 (11%)

Query: 29   SEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLL 88
            +  +  L  ++++   +    +TL+ +   L  E   L N L     E +TQ+     L 
Sbjct: 645  NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 704

Query: 89   EELRGELVEKTKDLEEMKLQI--LTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
            ++      +  K++E M L+   LT Q +E L  ++Q  L   + ++ R   +   +Y +
Sbjct: 705  QKAEFSDQKHQKEIENMCLKTSQLTGQ-VEDLEHKLQL-LSNEIMDKDRCYQDLHAEYES 762

Query: 147  VYNKLRYEHTFLKSEFEHQKE------------EYARILDE-GKIKYESEIARLEEDKEE 193
            + + L+ +   L +  +HQ+              +A I+ E G +  E    RLE D+  
Sbjct: 763  LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822

Query: 194  -----LRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE--LKAEKENSEAQVE 246
                 L+N++ +++ + +S++  Q+  +    C++L  ++ E+ E  +KAE+ +     E
Sbjct: 823  KNSAILQNRVDSLEFSLESQK--QMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE 880

Query: 247  NAQRIQVRQ---------LAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINK 297
             +QRI   Q         +AE  + + + E E Q  N + E  + E+Q   + N  L + 
Sbjct: 881  TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940

Query: 298  LHKAEREINTLSSKVKELK---HSNKLEITDIKLETARAK---SELERER-NKIQSE--- 347
            L + +    TLS + KE+      NK EI ++  E    K   + L +E+ N IQ     
Sbjct: 941  LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000

Query: 348  ---LDGLQSDNEILKAAVEHHKVLLVEKDRE-------LIRKVQAAKEEGYQKLVVLQDE 397
               +D  +     L    +  K++L+++  E       L +K +AA+E+   KL  L +E
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN-SKLECLLNE 1059

Query: 398  KLEL-ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIV 456
               L ENR  +LE++K         E  ++  KL  ++   +    EL++V+  L+ ++ 
Sbjct: 1060 CTSLCENRKNELEQLKEAF----AKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115

Query: 457  TIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQ 516
              +N    K+E   LKQ+I +L+ +   + +  NDLL  N+ L + V + K EC+N  S+
Sbjct: 1116 --DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMK-VMKTKHECQNLESE 1172

Query: 517  AEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHEN 576
              +  ++ E+  E  Q  +  +     + I+   + YN   + +Q  A+ + K     E 
Sbjct: 1173 PIRNSVK-ERESERNQCNFKPQMDLEVKEIS--LDSYN--AQLVQLEAMLRNK-----EL 1222

Query: 577  KLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVP 636
            KL+  +++ E L+ + + +  + +  N Q++  ++ + L+    D + ++      I  P
Sbjct: 1223 KLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKY------ISGP 1276

Query: 637  NMPPTASINPVSFQSSAMVPSMEL----PFPPHMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   T+  +    Q S      +L         +Q E+++    L   R  E  T  RK 
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR-SECITATRKM 1335

Query: 693  LEELG 697
             EE+G
Sbjct: 1336 AEEVG 1340



 Score =  109 bits (273), Expect = 8e-24
 Identities = 139/584 (23%), Positives = 269/584 (46%), Gaps = 74/584 (12%)

Query: 52   LKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEELRGELVEKTKDLEEM 105
            L+ ++   Q   V L+ EL  + +E+   + +L  +      L++L  ++ EKT++LE  
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQ 165
            + + L    +++  A+++++ E       + L  +V       ++L  + T L+ + +  
Sbjct: 1995 QSECL--HCIQVAEAEVKEKTEL-----LQTLSSDV-------SELLKDKTHLQEKLQSL 2040

Query: 166  KEEYARILDEGKIKYESEIARLEEDKEEL--RNQLLNVDLTKD-------SKRVEQLARE 216
            +++ ++ L   K + E++IA+L ++KE L   ++ L   L++        SK +E    E
Sbjct: 2041 EKD-SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2099

Query: 217  KVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLR 276
            K     +L   + EV +L+   E    ++E  ++ Q+  +AE    ++  E E  S   +
Sbjct: 2100 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH-IAEK---LKERERENDSLKDK 2155

Query: 277  AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSE 336
             E LE+ELQ S E    +I     ++ E+ TL ++++E+  S K+     +L+    +SE
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKV----FELDLVTLRSE 2211

Query: 337  LERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD 396
             E    +IQ +   L   +++L +     K LL EK++  I+     KEE    + +LQ+
Sbjct: 2212 KENLTKQIQEKQGQLSELDKLLSS----FKSLLEEKEQAEIQ----IKEESKTAVEMLQN 2263

Query: 397  EKLELENRLA----DLEKMKVEHDVWRQSEKDQYE-----EKLRASQMAEEITRKELQSV 447
            +  EL   +A    D E MK          +++++     EKLRA   A+E  +K+L   
Sbjct: 2264 QLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADE--KKQL--- 2318

Query: 448  RLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLK 507
               LQQ   +  +A+  K    +L++++   +      A    +     + LK  +E + 
Sbjct: 2319 -CVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMT 2377

Query: 508  QECRNFR-----SQAEKAQLEAEKTLEEKQIQWLEEKHKLHERI-TDREEKYNQAKEKLQ 561
            Q  R         ++EK  L  E   E+++I  LE  +   E I  ++E++  Q KEK  
Sbjct: 2378 QSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS 2437

Query: 562  RAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQ 605
             A         + + +LK L E+V  L   +E  + + Q L+ Q
Sbjct: 2438 TA-------MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474



 Score =  103 bits (258), Expect = 4e-22
 Identities = 142/714 (19%), Positives = 304/714 (42%), Gaps = 72/714 (10%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLL---EELRGEL 95
            R+R E  +     +  +    + E+  L++++++L  E Q  +E  +L++   E  + E+
Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184

Query: 96   VEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEH 155
                  +EEM  + L   +L+L+  + ++E  T   +  +    E++K  + +  L  E 
Sbjct: 2185 ETLKTQIEEMA-RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243

Query: 156  TFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKE-------------ELRNQLLNVD 202
               + + + + +    +L     +    +A L  D+E             E  +QL N  
Sbjct: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN-S 2302

Query: 203  LTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQ-- 260
            + K   R+E   ++++ + Q+LK  E     LK   EN E ++E A+  Q     E +  
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362

Query: 261  -ATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAER---EINTLSSKVKELK 316
               V +L+A+ +        LE ++ +   +   L N+L K +    E+  ++S  + + 
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422

Query: 317  HSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEH--HKVLLVEKDR 374
               + E   +K +++ A   L+ +  ++   +  L +D E  KA  ++   +V  +E ++
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482

Query: 375  -ELIRKVQAAK-----------------EEGYQKLVVLQDEKLELENRLAD-------LE 409
             +L++ +  AK                 E+G QKL    +E   L+N++ D       L 
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542

Query: 410  KMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK--ELQSVRLKLQQQIVTIENAEKE-KN 466
            +++ EH +W+       E+ L    +  E+ +K   LQS    LQ  +  ++++ K  +N
Sbjct: 2543 QVEGEHQLWK-------EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN 2595

Query: 467  ENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQ-AEKAQLEAE 525
            E    K    S   +V  +   E +L      + +    L++E    +++ A + QL  E
Sbjct: 2596 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2655

Query: 526  K------TLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLK 579
            +       L+E  ++  E K  L     D+ EK  + +E++    +   + +  H+  L 
Sbjct: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLL 2715

Query: 580  RLQEKVEV-LEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNM 638
               ++ EV ++  +E+L ++ + L+ Q +  +     ++ L +  +   +    +    M
Sbjct: 2716 DTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM 2775

Query: 639  PPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                 +N +  ++      M+L      Q E+   E  +L+K L +L+  Q KQ
Sbjct: 2776 DNLKYVNQLKKENERAQGKMKLLIKSCKQLEE---EKEILQKELSQLQAAQEKQ 2826



 Score =  103 bits (256), Expect = 7e-22
 Identities = 138/578 (23%), Positives = 271/578 (46%), Gaps = 69/578 (11%)

Query: 40   LRCEHHKANYQTLKAEHTR-------LQNEHVKLQNELKHLFNEKQTQQEKL-QLLLEEL 91
            L  E+ K   +TLKA+          L+ + V +++E ++L NE Q +QE++ +L +   
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416

Query: 92   RGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKL 151
              E + + K+ E+++++  +   +E+L+ Q+++     + ER   L  + E  +A    L
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE-----LNERVAALHNDQEACKAKEQNL 2471

Query: 152  RYEHTFLKSEFEHQKEEYARILDEGKIKY---ESEIARLEEDKEELRNQLLNVDLTKDSK 208
              +   L+ E    K +  + LDE K  Y   +S +  L ++ E+ + +L   D  ++  
Sbjct: 2472 SSQVECLELE----KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD--EEIS 2525

Query: 209  RVEQLAREKVYLCQKLKGLEAEVAELKAEK-ENSEAQVENAQRIQVRQL--AEMQATVRS 265
            R++   +++  L  KL  +E E    K +  E     VE  Q+IQV Q   A +Q T+  
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585

Query: 266  LEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITD 325
            L++  ++       LE EL+ +       + K       +N +++K  EL+     E+ +
Sbjct: 2586 LQSSYKN-------LENELELTKMDKMSFVEK-------VNKMTAKETELQR----EMHE 2627

Query: 326  IKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKE 385
            +  +TA  + EL  E+N++  EL  L  +   +K++ +  K L +E   EL + +    +
Sbjct: 2628 MAQKTAELQEELSGEKNRLAGELQLLLEE---IKSSKDQLKELTLENS-ELKKSLDCMHK 2683

Query: 386  EGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKE-- 443
            +  +K   +++E  E + RL + EK   +H         QYE +++  +  E++T KE  
Sbjct: 2684 DQVEKEGKVREEIAEYQLRLHEAEK---KHQALLLDTNKQYEVEIQTYR--EKLTSKEEC 2738

Query: 444  LQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMV 503
            L S +L++      ++++++E N +     QI      +  L +++ D L     LK+  
Sbjct: 2739 LSSQKLEID----LLKSSKEELNNSLKATTQI------LEELKKTKMDNLKYVNQLKKEN 2788

Query: 504  ERLKQECRNFRSQAEKAQLEAEKTLEEK---QIQWLEEKHKLHERITDREEKYNQAKEKL 560
            ER + + +      +  QLE EK + +K   Q+Q  +EK K    +  + ++     ++L
Sbjct: 2789 ERAQGKMKLLIKSCK--QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKEL 2846

Query: 561  QRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETE 598
            +     + K    + +K   L    E LE  KE LET+
Sbjct: 2847 KETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 130/634 (20%), Positives = 261/634 (41%), Gaps = 71/634 (11%)

Query: 28  QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
           + EFQ+ L          + ++QTL  E  +++    +   + K++ N  Q + +KL  +
Sbjct: 393 EKEFQEEL-------SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV 445

Query: 88  LEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAV 147
            ++L         +LEE K ++   ++      Q  Q  E  +R     + +E    ++ 
Sbjct: 446 KQQLE-------NNLEEFKQKLCRAEQ----AFQASQIKENELRRSMEEMKKENNLLKSH 494

Query: 148 YNKLRYEHTFLKSEFEHQKE---EYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLT 204
             +   E   L++E ++ K+   +     +E K K  S+   L + +E++  Q  ++ L 
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554

Query: 205 KDSKRVEQLAREKVYLCQKLKGLEAEVAEL-----KAEKEN----SEAQVENAQRIQVRQ 255
           K    V  L +++      LK  E  + +L     K EKE+    S  +++  +  ++++
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614

Query: 256 --------LAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINT 307
                    +E +  +  +E+EK++   +   LE  L++   ++     ++   E +   
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674

Query: 308 LSSKVKELKH---SNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE- 363
           LS +++ L +   S  +E+   KL     + + E    K Q E++ +      L   VE 
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734

Query: 364 -HHKVLLVEK---DRELIRKVQAAKEEGYQKLVVLQDEKL----ELENRLADLEKMKVEH 415
             HK+ L+     D++   +   A+ E  + L+  +D  L    + +  L   ++    H
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794

Query: 416 DVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIE-NAEKEKNENSDLKQQ 474
             +     +Q       S+   E  +    S    LQ ++ ++E + E +K  NSDL++Q
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSA--ILQNRVDSLEFSLESQKQMNSDLQKQ 852

Query: 475 ISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQ 534
              L   V    + E +L+ + QM +  V    Q     +      Q    +TL      
Sbjct: 853 CEEL---VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA---- 905

Query: 535 WLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEE 594
            LE K K  + + D+ E      ++L       KK   L E+ LK LQ   E L  +K+E
Sbjct: 906 -LENKEKELQLLNDKVETEQAEIQEL-------KKSNHLLEDSLKELQLLSETLSLEKKE 957

Query: 595 LETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNE 628
           +   + +++      E+ T+    LK+I    N+
Sbjct: 958 M---SSIISLNKREIEELTQENGTLKEINASLNQ 988



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 148/721 (20%), Positives = 307/721 (42%), Gaps = 91/721 (12%)

Query: 52  LKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK---LQLLLEELRGELVEKTKDLEEMKLQ 108
           LKA++  L+N+  +L+  L+    E + Q  K   LQL LE+ + EL+EK K L + + +
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE 342

Query: 109 IL---------------TPQKLELLRAQIQQE----------LETPMRERFRNLDEEVEK 143
           ++                 QKL+ L   +  +          LE  ++E+ +   EE+ +
Sbjct: 343 LVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSR 402

Query: 144 YRAVYNKLRYEHTFLKSEFE---HQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLN 200
            +  +  L  E   +K+       Q +    +L     K  S   +LE + EE + +L  
Sbjct: 403 QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCR 462

Query: 201 VDLTKDSKRV---------EQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRI 251
            +    + ++         E++ +E   L    +    EV  L+AE +N +  +  +Q  
Sbjct: 463 AEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF 522

Query: 252 QVRQLAE---MQATVRSLEAE--KQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
                A+    +  +R L+ +  +Q  +L  E+L+  +    +Q     + L K E  I 
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIE 582

Query: 307 TLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK 366
            L+ K+ + +  +K  ++ ++L+  +   EL+ E+          +S+NE L   +E  K
Sbjct: 583 QLNDKLSKTEKESKALLSALELK-KKEYEELKEEKTLFSC----WKSENEKLLTQMESEK 637

Query: 367 VLLVEK--DRELIRKVQAAKEEGYQKLV-VLQDEKLELENRLADLEKMKVEHDVWRQSEK 423
             L  K    E   K Q  K   Y + V  L+ ++  L   + +L  +     V  +++K
Sbjct: 638 ENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQK 697

Query: 424 DQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKE----KNENSDLKQQISSLQ 479
             Y E  + ++ +++  +KE++++ LK  Q    +E+ E +     NE  D  +    L 
Sbjct: 698 LAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLH 757

Query: 480 IQVTS---LAQSENDLLNSNQMLKEMVERLKQ-------------ECRNFRSQAEKAQLE 523
            +  S   L +S++  L +N+  +  +    Q             E  +  S+  + +LE
Sbjct: 758 AEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLE 817

Query: 524 AEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQ- 582
           A+++ +   I  L+ +    E   + +++ N   +K Q   + Q K + + EN +K  Q 
Sbjct: 818 ADQSPKNSAI--LQNRVDSLEFSLESQKQMNSDLQK-QCEELVQIKGE-IEENLMKAEQM 873

Query: 583 EKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTA 642
            +  V E  +   + +      QNV  E  + L+ + K++Q  +++  +          A
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET--------EQA 925

Query: 643 SINPVSFQSSAMVPSME----LPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGS 698
            I  +   +  +  S++    L     +++++    +SL ++ +EEL T +   L+E+ +
Sbjct: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL-TQENGTLKEINA 984

Query: 699 S 699
           S
Sbjct: 985 S 985



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 145/692 (20%), Positives = 285/692 (41%), Gaps = 83/692 (11%)

Query: 69  ELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELET 128
           +LK  +N++  ++++L+  ++ L+ +   +T     M  + +   +        QQE +T
Sbjct: 166 DLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE-KT 224

Query: 129 PMRERFRNLDEEVEK-YRAVYNKLRYEHTFLKSEFEHQKEEY-ARILDEGKIKYESEIAR 186
           P      +    + + + A Y     E T  +S  +  K +  +   D     +  +  +
Sbjct: 225 PSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD--Q 282

Query: 187 LEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVE 246
           L+   +ELRN++  ++L     R++   +E      K + L+ ++ + K E    E  + 
Sbjct: 283 LKAQNQELRNKINELEL-----RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337

Query: 247 NAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREIN 306
             +   VR  A+         A +Q      E L  + Q++      L  K+ + E+E  
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ 397

Query: 307 TLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK 366
              S+ +    +   E   +K    +   + +   N +Q+ELD L S  + L+  +E  K
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK 457

Query: 367 VLLVE----------KDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHD 416
             L            K+ EL R ++  K+E        + +  E+ +  A+L+ +K    
Sbjct: 458 QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK---Q 514

Query: 417 VWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIE-------NAEKEKNENS 469
              QS+   + E+++A   ++E   ++LQ  ++  Q+  +T+E       + EK+++ + 
Sbjct: 515 CLNQSQ--NFAEEMKAKNTSQETMLRDLQE-KINQQENSLTLEKLKLAVADLEKQRDCSQ 571

Query: 470 DL----KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNF---RSQAEK--A 520
           DL    +  I  L  +++   +    LL++ ++ K+  E LK+E   F   +S+ EK   
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631

Query: 521 QLEAEKTLEEKQIQWLE--------EKHKLHERITDRE-EKYNQAKEKLQRAAIAQKKRK 571
           Q+E+EK   + +I  LE        + H+ +ER+   E ++ N + E      +   K  
Sbjct: 632 QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691

Query: 572 SLHENKL--KRLQEKVEVLEAKKEELETENQVLNRQNV--PFEDYT-RLQKRLKDI---- 622
            +   KL    LQ+K E  + +K + E EN  L    +    ED   +LQ    +I    
Sbjct: 692 EVETQKLAYMELQQKAEFSD-QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 623 ---QRRHNEFRSL---------ILVPNMPPTASI-----NPVSFQSSAMVPSMELPFPPH 665
              Q  H E+ SL          LV N     S+      P    S A +   +   P  
Sbjct: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810

Query: 666 MQE-----EQHQRELSLLRKRLEELETTQRKQ 692
             E     +Q  +  ++L+ R++ LE +   Q
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQ 842



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 95/436 (21%), Positives = 191/436 (43%), Gaps = 50/436 (11%)

Query: 222 QKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEK-QSANLRAE-- 278
           QK++ LE ++ +LK EK+  + Q+++ +       A +Q   + +E EK +  NL+ E  
Sbjct: 18  QKIQELEGQLDKLKKEKQQRQFQLDSLE-------AALQKQKQKVENEKTEGTNLKRENQ 70

Query: 279 RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELE 338
           RL +  +S  +    + ++L   E ++N    ++    +S K +I  ++ E  R KSELE
Sbjct: 71  RLMEICESLEKTKQKISHELQVKESQVNFQEGQL----NSGKKQIEKLEQELKRCKSELE 126

Query: 339 RERNKIQS---ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQ 395
           R +   QS    L+   +  +I    +   +     K  +L  K     EE  +K +  +
Sbjct: 127 RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE--RKRLEAE 184

Query: 396 DEKLELENRLADLEKMKVEH-DVWR---QSEKDQYEEKLRASQMAEEI----TRKELQSV 447
            + L+ +     L +  + H D+ R    S    ++++   S ++        R++  + 
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244

Query: 448 RLKLQQQIVTIENAEK--EKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
               +Q++    +  +  +++ NS      SS  + +  L     +L N    + E+  R
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL-LDQLKAQNQELRNK---INELELR 300

Query: 506 LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEK---HKLHERITDREEKYNQAKEKLQR 562
           L+   +  + Q  K Q E +  LE+ +++ +E++   +K  + +     +Y+QA  K   
Sbjct: 301 LQGHEKEMKGQVNKFQ-ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY-- 357

Query: 563 AAIAQKKRKSLHENKLKRLQEKVE--VLEAKKEELETE-NQVLNRQNVPFEDY------- 612
            A+ QK +K   +   +R   +     LE K +E E E  + L+RQ   F+         
Sbjct: 358 TALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417

Query: 613 -TRLQKRLKDIQRRHN 627
             RL + L+  +  HN
Sbjct: 418 KARLTQELQQAKNMHN 433



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 84/328 (25%), Positives = 136/328 (41%), Gaps = 71/328 (21%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKHLFNEKQ-TQQEKLQLL------------LEELRGELV 96
            Q L++++  LQ+    LQ+  K+L NE + T+ +K+  +            L+    E+ 
Sbjct: 2570 QVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMA 2629

Query: 97   EKTKDLEEMKLQILTPQK------LELLRAQIQ------QELETPMRERFRNLD----EE 140
            +KT +L+E     L+ +K      L+LL  +I+      +EL     E  ++LD    ++
Sbjct: 2630 QKTAELQEE----LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685

Query: 141  VEKYRAVYNKL-RYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE---DKEE-LR 195
            VEK   V  ++  Y+    ++E +HQ    A +LD  K +YE EI    E    KEE L 
Sbjct: 2686 VEKEGKVREEIAEYQLRLHEAEKKHQ----ALLLDTNK-QYEVEIQTYREKLTSKEECLS 2740

Query: 196  NQLLNVDLTKDSKR--------------------------VEQLAREKVYLCQKLKGLEA 229
            +Q L +DL K SK                           V QL +E      K+K L  
Sbjct: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIK 2800

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQL--AEMQATVRSLEAEKQSANLRAERLEKELQSS 287
               +L+ EKE  + ++   Q  Q +Q     M   V  L  E +      E   KE    
Sbjct: 2801 SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860

Query: 288  SEQNTFLINKLHKAEREINTLSSKVKEL 315
             ++   L+    K E+    L ++V  L
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 124/557 (22%), Positives = 234/557 (42%), Gaps = 98/557 (17%)

Query: 48   NYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKL 107
            N Q ++ E   L+N+ +KLQ        E + ++E LQ  L+ +RG+L  +T +L++M+ 
Sbjct: 1207 NAQLVQLE-AMLRNKELKLQ--------ESEKEKECLQHELQTIRGDL--ETSNLQDMQS 1255

Query: 108  QILT----------------PQKLELLR---AQIQQELETPMRERFRNLDEEVEKYRAVY 148
            Q ++                P +L   +   A +Q  L+T M     N   E+EK   + 
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTM-----NKLNELEKICEIL 1310

Query: 149  NKLRYEHTFLKSEFEHQKEEY---ARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTK 205
               +YE   L +E    + E     R + E   K  +E+  L +D   L  +L+  D+  
Sbjct: 1311 QAEKYE---LVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE-DIPG 1366

Query: 206  DSKRVEQLAREKV------------YLCQKLKGLEAEVAELKAE--KENSEAQVENAQRI 251
                 +   +  V            +L    K ++   AEL+ +     SE ++ + Q  
Sbjct: 1367 GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHC 1426

Query: 252  QVR-QLAEMQATVRSLEAEKQ--SANLRAER--LEKELQSSSEQNTFLINKLHKAEREIN 306
            Q+  +++E+Q  V SL+AE    S NLR  +  L KE+Q   E+              + 
Sbjct: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL------------VP 1474

Query: 307  TLSSKVKELKHSNKLEITDIKLETARAKSELERERN-KIQSELDGLQSDNEILKAAVEHH 365
            +LSS    +  S+ L       +++  ++ LE+  +  + S L+G  S N+    +V+  
Sbjct: 1475 SLSSSC--VPDSSSLSSLG---DSSFYRALLEQTGDMSLLSNLEGAVSANQ---CSVDEV 1526

Query: 366  KVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQ 425
                ++++    ++  +A  +G ++L  L +        L  LE+      + +  E  +
Sbjct: 1527 FCSSLQEENLTRKETPSAPAKGVEELESLCEV---YRQSLEKLEEKMESQGIMKNKEIQE 1583

Query: 426  YEEKLRASQMAEEITRKELQSVRLKLQQQI--VTIENAEKEKNENSDLKQQISSLQIQVT 483
             E+ L + +   +  RK+  S   + QQ++  VT+E   K   E    +Q   SL+++V 
Sbjct: 1584 LEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQL--SLELEVA 1641

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L     D L+S  +L    E   Q       + E   +  E T E  +     + H++ 
Sbjct: 1642 RLQLQGLD-LSSRSLLGIDTEDAIQ------GRNESCDISKEHTSETTERTPKHDVHQIC 1694

Query: 544  ERITDREEKYNQAKEKL 560
            ++  D ++  N   EK+
Sbjct: 1695 DK--DAQQDLNLDIEKI 1709


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  114 bits (285), Expect = 3e-25
 Identities = 157/657 (23%), Positives = 285/657 (43%), Gaps = 94/657 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNE-HVKLQNELKHLFNEKQTQ---QEK 83
            + E Q++  D+R   E  +     LK   + +QNE    LQ     L NE+Q +   QE+
Sbjct: 1012 EKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQ 1071

Query: 84   LQLLLE---ELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQ----------ELETPM 130
             ++ +E   +   EL+    D+E ++       K+  +R  +++          E +   
Sbjct: 1072 AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASW 1131

Query: 131  RERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEED 190
             ER R L +EV K       L  ++  L  + E   ++    + EG              
Sbjct: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV------------- 1178

Query: 191  KEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR 250
                    LNV L+++ K  EQ+     ++ +     E E+AE + E    E+ +   QR
Sbjct: 1179 -----QGPLNVSLSEEGKSQEQILEILRFIRR-----EKEIAETRFEVAQVES-LRYRQR 1227

Query: 251  IQVRQLAEMQATVRSLEAEKQSANLRA------ERLEKELQSSS---EQNTFLINKLHKA 301
            +++ +  E+Q    SL AE++   + A      E L K+ ++ +   E N  L  +  + 
Sbjct: 1228 VELLE-RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286

Query: 302  EREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAA 361
            E+++  + +KV+      KLE+  + L+ A A  EL  +   +Q+E   L+ D +  KA 
Sbjct: 1287 EQDLQQMQAKVR------KLELDILPLQEANA--ELSEKSGMLQAEKKLLEEDVKRWKAR 1338

Query: 362  VEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQS 421
             +H      + D E  RK+ + KE   +++  L +E   L+  +A        +    QS
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398

Query: 422  EKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEK----EKNENSDLKQQ--- 474
             K    E L   +  +E  +K+L +  + +Q+++ TI   +K     K +  +LK Q   
Sbjct: 1399 LK----EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDK 1454

Query: 475  ISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ-----LEAE-KTL 528
            +     Q +   Q ++  +   Q LKE + + + + ++  SQ E  Q      E E + L
Sbjct: 1455 VMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL 1514

Query: 529  EEKQIQWLEEKHKLHERITDR---EEKYNQ---AKEKLQRAAIAQKKRKSLHENKLK--- 579
            +E+ +Q   E  +L + + DR   EE+  Q    KE+  R AI   K K  H   +K   
Sbjct: 1515 QEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574

Query: 580  -----RLQEKVEVLEAKKEELETENQVLNRQNVPFED-YTRLQKRLKDIQRRHNEFR 630
                  L+++   L+ +K+EL+     L  Q   +E   +RL++ L++ Q RH E R
Sbjct: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQ---YEGRISRLERELREHQERHLEQR 1628



 Score =  101 bits (251), Expect = 3e-21
 Identities = 177/739 (23%), Positives = 303/739 (41%), Gaps = 166/739 (22%)

Query: 48   NYQTLKAEHTRLQNEHV-KLQNELKHLFNEK---QTQ----QEKLQLLLEELRGELVEKT 99
            NY+  KAE+ ++QNE + KLQ ++  L ++     TQ     ++ ++L + + G   E T
Sbjct: 681  NYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT 740

Query: 100  KDLEEMKLQILTPQKLELLRAQIQQELETPMRE------RFRNLDEEVEKYRAVYNKLRY 153
               E  +    T QK E +   + Q+L     +      R  NL +E E  +    +L  
Sbjct: 741  SLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQ 800

Query: 154  EHTFLKSEFEHQK------EEYARILD----EGKIKYESEIARLEED----KEELRNQL- 198
            +   L +E   Q       +    IL+    E K +  S+I +LE +    K++L N++ 
Sbjct: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860

Query: 199  --------LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQV--ENA 248
                    L+V L    ++++      +   + LK  + E+A LK    N E QV  +++
Sbjct: 861  QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSS 920

Query: 249  QRI----------------QVRQLAEM------------------QATVRSLEA----EK 270
            QR                 Q+RQ  E                   QA V SLE     EK
Sbjct: 921  QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980

Query: 271  QSANLRAERLEKELQSSSEQNTFLINKLHKAERE-----------INTLSSKVKELKHSN 319
            Q      + +E  L+ S+E  T L  KL + E+E           I ++  ++ ELK + 
Sbjct: 981  QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040

Query: 320  KLEITDIKLETARAKSELERE-----------------RNKIQSELDGLQSDNEILKAA- 361
                 +++    RA + L  E                 +NK + EL    +D E L+AA 
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK 1100

Query: 362  --------VEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM-K 412
                    V  H     +K    + + +A+ EE  +   +L+DE  +   R  DLEK  +
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERER---MLKDEVSKCVCRCEDLEKQNR 1157

Query: 413  VEHD-VWRQSEK------------------------DQYEEKLRASQMAEEITRKELQSV 447
            + HD + + S+K                        +Q  E LR  +  +EI     +  
Sbjct: 1158 LLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVA 1217

Query: 448  RLKLQQQIVTIENAEKEKNENSD-LKQQISSLQIQVTSLAQSE---------NDLLNSNQ 497
            +++  +    +E  E+E  E  D L  +   +Q+   ++AQ E         N ++ +N+
Sbjct: 1218 QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK 1277

Query: 498  MLKEMVERLKQECRNFRSQAEKAQL------EAEKTLEEKQIQWLEEKHKLHERITDREE 551
            ML+E  ERL+Q+ +  +++  K +L      EA   L EK    L+ + KL E    R +
Sbjct: 1278 MLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS-GMLQAEKKLLEEDVKRWK 1336

Query: 552  KYNQAKEKLQRAAIAQKKRKSLHENKL--KRLQEKVEVLEAKKEELETENQVL-NRQNV- 607
              NQ     Q+    ++ RK L E ++  KR+Q+  E +   K E+   N  L N QN+ 
Sbjct: 1337 ARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLI 1396

Query: 608  --PFEDYTRLQKRLKDIQR 624
                ED  +++   + IQ+
Sbjct: 1397 QSLKEDLNKVRTEKETIQK 1415



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 137/657 (20%), Positives = 279/657 (42%), Gaps = 74/657 (11%)

Query: 22  SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQ 81
           +GL  S    QK + D   + +  K    +++ +     N H+KL N  K   ++ + + 
Sbjct: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300

Query: 82  EKLQLLLEELR---GELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLD 138
            +L   +EEL     E  E  K +++  L++           Q + ++E  M E+   L+
Sbjct: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEV----------EQSKDQMEKEMLEKIGRLE 350

Query: 139 EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL 198
           +E+E    + +  + +   L  E        A  + +  +K   ++  L     E ++QL
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAK-IVKPGMKLTELYNAYVETQDQL 409

Query: 199 LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
           L   L  ++KR+ +      YL + +K +EA+   LK ++E  E   +    + V+    
Sbjct: 410 LLEKL--ENKRINK------YLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461

Query: 259 MQATVRSLE----AEKQSANLRAE--RLEKELQSSSEQNTFLINKLHKAEREINTLSSKV 312
           M+   R  E    A KQS+ L  +  R+E +++  S+Q   L+ +L +A         +V
Sbjct: 462 MKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEV 521

Query: 313 KELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKV--LLV 370
                S+  E+    L + R   EL+++  ++   L  L    E  +      K+  L +
Sbjct: 522 SSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581

Query: 371 EKDRELIRKVQAAKEEGYQ--------------KLVVLQDEKLELENRLADLEKMKVEHD 416
           + +  L    Q  K   +Q              ++++ Q   + +    + L+ + +   
Sbjct: 582 KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641

Query: 417 VWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLK-QQI 475
             R S      + +        I   E    +  L+Q     EN +KEK EN  ++ +Q+
Sbjct: 642 PKRPST----SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697

Query: 476 SSLQIQVTSLAQSENDLLNSN--------QMLKEMVERLKQECRNFRSQAEKAQLEAEKT 527
             LQ QVT L +S+N  +++         +ML++ VE  ++E  +   + +K     +K 
Sbjct: 698 EKLQEQVTDL-RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK- 755

Query: 528 LEEKQIQWL-EEKHKLHERITDREEKYNQAKE-----KLQRAAIAQKKRKSLHENK---- 577
            +E+ I  + ++    +E++   E +    K+     KL    ++Q++   L E +    
Sbjct: 756 -QEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814

Query: 578 -LKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLK-DIQRRHNEFRSL 632
            L  LQ    +LE  + E ET+ ++ ++      + + L+K+L+ ++++RH   R+L
Sbjct: 815 LLTNLQTIQGILE--RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 115/584 (19%), Positives = 241/584 (41%), Gaps = 67/584 (11%)

Query: 145 RAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLT 204
           ++V NKL       +SE +  K  + +   E + +Y     RL   +E L N+       
Sbjct: 19  KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE------- 71

Query: 205 KDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVR 264
             ++  + L  E   L  +LK L          ++N E ++   + I ++  ++   T  
Sbjct: 72  --TRECQSLRLELEKLNNQLKALT---------EKNKELEIAQDRNIAIQ--SQFTRTKE 118

Query: 265 SLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
            LEAEK+      ERL +EL+  +E     + +L++  +E NT   ++ +LK  ++L+ +
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTED----VKRLNEKLKESNTTKGEL-QLK-LDELQAS 172

Query: 325 DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR---KVQ 381
           D+ ++    +  LE+E+  + S+   L ++   LK   +    L  EK  E++     ++
Sbjct: 173 DVSVK--YREKRLEQEKELLHSQNTWLNTE---LKTKTDELLALGREKGNEILELKCNLE 227

Query: 382 AAKEEG---YQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEE 438
             KEE     +++  L+     L+  + DL     E    + S ++++  +L A      
Sbjct: 228 NKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN 287

Query: 439 ITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQM 498
           + +        K  +    +E   K   E  +  + I    ++V           + +QM
Sbjct: 288 LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ---------SKDQM 338

Query: 499 LKEMVE---RLKQECRNFRSQAEKAQLEAEKTLEEKQIQW------LEEKHKLHERITDR 549
            KEM+E   RL++E  N        + +     EE+          + +  K   ++T+ 
Sbjct: 339 EKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL 398

Query: 550 EEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPF 609
              Y + +++L    +  K+     +  +K ++ K  +L+ ++EE E   + +   +V  
Sbjct: 399 YNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL 458

Query: 610 EDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHM--Q 667
           E   +  +RL++   + N+  S++   N      +  +S Q   ++  +E     H+   
Sbjct: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518

Query: 668 EEQHQRELS----------LLRKRLEELETTQRKQLEELGSSGE 701
           EE    ++S          +  + +EEL+   ++ L  L   GE
Sbjct: 519 EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE 562



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 76/348 (21%), Positives = 145/348 (41%), Gaps = 48/348 (13%)

Query: 321 LEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE-----------HHKVLL 369
           LE T++       +++LE+     QSE+DGL+  +E  K   E           H +  L
Sbjct: 9   LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68

Query: 370 VEKDRE----------LIRKVQAAKEEGYQKLVVLQDEKLELENRLA-DLEKMKVE-HDV 417
           V + RE          L  +++A  E+  ++L + QD  + ++++     E+++ E  D+
Sbjct: 69  VNETRECQSLRLELEKLNNQLKALTEKN-KELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127

Query: 418 WRQSEKDQYE--------EKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKE----- 464
            R +E+   E        ++L         T+ ELQ    +LQ   V+++  EK      
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187

Query: 465 ---KNENSDLKQQISSLQIQVTSLAQSE-NDLLNSNQML---KEMVERLKQECRNFRSQA 517
               ++N+ L  ++ +   ++ +L + + N++L     L   KE V RL+++    ++  
Sbjct: 188 ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247

Query: 518 EKAQLEAE---KTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLH 574
           E  Q   E     L+E + Q    + K H  +    +  N  K     +     +     
Sbjct: 248 EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAV 307

Query: 575 ENKLKRLQEKVEVLEAKKEE-LETENQVLNRQNVPFEDYTRLQKRLKD 621
           E   K L+E  E  +A ++  LE E      +    E   RL+K L++
Sbjct: 308 EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELEN 355


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score =  114 bits (284), Expect = 4e-25
 Identities = 162/726 (22%), Positives = 298/726 (41%), Gaps = 92/726 (12%)

Query: 34   MLIDERLRC-EHHKANYQ-TLKAEHTRLQNEHVKLQNE-LKHLFNEKQTQQEKLQLLLEE 90
            +L +  L+C E  K N+Q + K E  + Q E  K  N+ L+ L  E   ++E+LQ  +E 
Sbjct: 488  VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETP-MRERFRNLDEEVEKYRAVYN 149
            L+ +   + KDLE+ K  +         R+Q+  E     + +  + L + V +     +
Sbjct: 548  LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS 607

Query: 150  KLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKR 209
            +L +E   L  + E  KE+      E   K E E+ RL+E+   L  ++ +++    +++
Sbjct: 608  QLEFEKRQLHRDLEQAKEK-----GERAEKLERELQRLQEENGRLARKVTSLETA--TEK 660

Query: 210  VEQLAREKVYL-----------------CQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            VE L  E   L                   +L+GLE +  +L AE       VE   R  
Sbjct: 661  VEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVET-MRFT 719

Query: 253  VRQLAEMQATVRSLEAEKQ----------SANLRAERLEKELQSSSEQNTFLINKLHKAE 302
              +LA+M+   + LE EK+          +   ++ERLE   QS S +N  L   L  + 
Sbjct: 720  STKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS 779

Query: 303  REINTLSSKVKELKHSNKLEITDIK-LETARAKSE-LERERNKIQSELDGLQSDNEILKA 360
             +  TL S++ EL+   +    D++ L  A A+ E  E++R  ++ E+  L+ D ++L+ 
Sbjct: 780  HKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK 839

Query: 361  AVEH----------------HKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENR 404
              +                  K+  VEK+   + K  A   +   KL     ++LE +NR
Sbjct: 840  EAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKL-----KELEKDNR 894

Query: 405  LADLEKMKVEHD-VWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEK 463
              DL K    H        +D   EKL++ Q++ E+ +   +  ++ L ++++  E+   
Sbjct: 895  --DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSG 952

Query: 464  --------EKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRS 515
                    E    S LK  ++  + ++  L     +  + N+ L+  ++ LK+EC   R 
Sbjct: 953  SDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQ 1012

Query: 516  QAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHE 575
               + Q              L+   K     T    +  +A     + A  +  R    +
Sbjct: 1013 NQGEGQ-------------HLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV---K 1056

Query: 576  NKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILV 635
            ++   L+     L+A+K+ L+ + Q L  QNV F       ++     + HN   + +  
Sbjct: 1057 DRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHN---TTLQT 1113

Query: 636  PNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEE 695
                     + +S QS+A+     L    H  +E     L   +++L        +  E 
Sbjct: 1114 QTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEH 1173

Query: 696  LGSSGE 701
            LG+  E
Sbjct: 1174 LGTLHE 1179



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 165/695 (23%), Positives = 285/695 (41%), Gaps = 127/695 (18%)

Query: 59   LQNEHVKLQNELKHLFNEKQTQQEKLQLLLEE-LRGELVEKTKDLEEMKLQILTPQKLEL 117
            L+ E+++L+++L  L  ++ T +++++ LLEE +  E+ +K    E   L        EL
Sbjct: 383  LEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLG------WEL 436

Query: 118  LRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGK 177
             +     +L    R+ F     E    R +  KL  E+  L+S  +  ++  + +L+E  
Sbjct: 437  EQLSKNADLSDASRKSFVFELNECASSRIL--KLEKENQSLQSTIQGLRDA-SLVLEESG 493

Query: 178  IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAE 237
            +K       LE++  +L  ++         K   QL REK    Q  + LE    EL  E
Sbjct: 494  LK----CGELEKENHQLSKKI--------EKLQTQLEREK----QSNQDLETLSEELIRE 537

Query: 238  KENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINK 297
            KE  ++ +E  +  + RQ       ++ LE EK   N     L +  Q SSE     + K
Sbjct: 538  KEQLQSDMETLKADKARQ-------IKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEK 590

Query: 298  LHKA-EREINTLSSKVKELKHSNKLEITDIKLETARAKSE----LERERNKIQSELDGLQ 352
             +KA  + +   + K+ +L+   +    D  LE A+ K E    LERE  ++Q E   L 
Sbjct: 591  ENKALHQTVTEANGKLSQLEFEKRQLHRD--LEQAKEKGERAEKLERELQRLQEENGRLA 648

Query: 353  SDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMK 412
                 L+ A E  + L  E     +      K     + V LQ E LE +N+  D E ++
Sbjct: 649  RKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708

Query: 413  VEHDV----WRQSEKDQYEEKLRASQMAEEITRKEL--------QSVRLKLQQQIVTIEN 460
            +   V    +  ++  Q E + +  +  +E  RK +        +S RL+L  Q V+ EN
Sbjct: 709  LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN 768

Query: 461  A------EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFR 514
                   E   ++   L+ ++  L+ +  +L +    L  +N  L+   +  K       
Sbjct: 769  LRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA------ 822

Query: 515  SQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDRE-------EKYNQAKEK-LQRAAIA 566
             + E AQLE +K L EK+ + L ++ +L + + D         EK ++A +K L R   A
Sbjct: 823  LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDA 882

Query: 567  QKKRKSL-------------HENKLKRLQEKVEVLEAKKEEL---------ETENQVLNR 604
              K K L             H   L  L+E + + + K ++L         E E   LNR
Sbjct: 883  AGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNR 942

Query: 605  QNVPFEDYTRLQKRLKDIQRRH----------NEFRSLILVPNMPPTASINPVSFQSSAM 654
            + +  ED +    + K ++ R+           E + ++L   M   AS+N         
Sbjct: 943  ELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN--------- 993

Query: 655  VPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQ 689
                           Q + EL +L+K  E L   Q
Sbjct: 994  --------------RQLESELQMLKKECETLRQNQ 1014



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 173/820 (21%), Positives = 323/820 (39%), Gaps = 201/820 (24%)

Query: 27   SQSEFQKMLIDERLRCEHHKANY-QTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQ 85
            SQ EF+K  +   L     K    + L+ E  RLQ E+ +L  ++  L    +T  EK++
Sbjct: 607  SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSL----ETATEKVE 662

Query: 86   LLLEELRGELVE-----KTKD-LEEMKLQI---------LTPQKLELLR----------- 119
             L  E +G  +E     K+ D L+ + LQ+         L  + LEL R           
Sbjct: 663  ALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTK 722

Query: 120  -AQIQ---QELETPMRERFRNLD------EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEY 169
             AQ++   Q+LE    E  +N+D      ++ E+    Y  +  E+  L+   E    + 
Sbjct: 723  LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782

Query: 170  ARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEA 229
              +        ESE+  LE +++ LR  L  + L   + ++E   +++       K LE 
Sbjct: 783  QTL--------ESELGELEAERQALRRDLEALRLA--NAQLEGAEKDR-------KALEQ 825

Query: 230  EVAELKAEKENSEAQVENA-QRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSS 288
            EVA+L+ +K+  E + +   Q+++++      +T +    EK+S       L+KEL    
Sbjct: 826  EVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKES-----RALDKELARCR 880

Query: 289  EQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSEL 348
            +       KL + E++   L+ +V     +      D+ LE  +++ +L  E +K+  EL
Sbjct: 881  DA----AGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQ-QLSSELDKLSQEL 935

Query: 349  DGLQSDNEIL----KAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENR 404
            + +  + E+L     +  +    +L  ++   ++   A KEE    L    +EK  L  +
Sbjct: 936  EKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQ 995

Query: 405  L-ADLEKMKVEHDVWRQSE-------------------------------KDQYEEKLRA 432
            L ++L+ +K E +  RQ++                               K+   E LR 
Sbjct: 996  LESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV 1055

Query: 433  SQMAEEITR----------------KELQSVRLKLQQQIVTIENAE-------------- 462
               A E+ R                + L++  +    QI+T++                 
Sbjct: 1056 KDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT 1115

Query: 463  -KEKNENSDLKQQISSLQIQVTSLA------QSENDLLNSNQ-MLKEMVERLKQECRNFR 514
             K + ENS L  Q ++L  Q T L       ++EN+ L   Q  L    E L Q+  +  
Sbjct: 1116 AKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175

Query: 515  SQAEKAQLEAE--------------------KTLEEKQIQWLEEKHKLHER--ITDREEK 552
            +  E+   E E                    K L E+    L+ K +L ER  +   E +
Sbjct: 1176 TLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTERE 1235

Query: 553  YNQAKEKLQRAAIAQKKR-------------------KSLH------ENKLKRLQEKVEV 587
              Q +++    A+ + +R                   + LH      +  L   Q ++  
Sbjct: 1236 ALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNR 1295

Query: 588  LEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPV 647
             +A+ +EL+ ++Q ++      +++  L  RLK      N              + I  +
Sbjct: 1296 WQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHL----------LSQIQLL 1345

Query: 648  SFQSSAMV-PSMELPFPPHMQEEQHQRELSLLRKRLEELE 686
            S Q+  ++  +ME     H +++Q+  +L+ LR+  E+LE
Sbjct: 1346 SQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLE 1385



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 138/597 (23%), Positives = 241/597 (40%), Gaps = 96/597 (16%)

Query: 111 TPQKLELLRAQIQQELETPMRE---RFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKE 167
           TP     L ++ +Q L   + +   R R + +E+E         R+E   L  E +  K+
Sbjct: 237 TPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQ 296

Query: 168 EYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGL 227
           E  ++  + +       AR   D+ +         L + + RVE+L  E     +KL  +
Sbjct: 297 ENIQLAADARS------ARAYRDELD--------SLREKANRVERLELELTRCKEKLHDV 342

Query: 228 EAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSS 287
           +   A ++      E + +N   I+ + + E Q T      +K         LEKE    
Sbjct: 343 DFYKARME------ELREDNIILIETKAMLEEQLTAARARGDK------VHELEKE---- 386

Query: 288 SEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSE 347
              N  L +KLH  E + +T   +++EL   N +      LE A+ +S    E   +  E
Sbjct: 387 ---NLQLKSKLHDLELDRDTDKKRIEELLEENMV------LEIAQKQS--MNESAHLGWE 435

Query: 348 LDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELEN---R 404
           L+ L  + ++  A+ +     L E     I K++   +     +  L+D  L LE    +
Sbjct: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495

Query: 405 LADLEKMKVEHDVWRQSEKDQYE-EKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEK 463
             +LE  K  H + ++ EK Q + E+ + S    E   +EL   + +LQ  + T++    
Sbjct: 496 CGELE--KENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK---- 549

Query: 464 EKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLE 523
                +D  +QI  L        + E D LN          ++  E R    + E   L 
Sbjct: 550 -----ADKARQIKDL--------EQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALH 596

Query: 524 AEKTLEEKQIQWLE-EKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQ 582
              T    ++  LE EK +LH  +   +EK  +A EKL+R     ++       K+  L+
Sbjct: 597 QTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA-EKLERELQRLQEENGRLARKVTSLE 655

Query: 583 ---EKVEVLEAKKEELETENQVLNR-----QNVPFEDYTRLQKRLKDIQRRHNEFRSLIL 634
              EKVE LE + + L+ EN+ L +     QNV  +    L++  K +   + E R L+ 
Sbjct: 656 TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQ-LEGLERDNKQLDAENLELRRLVE 714

Query: 635 VPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
                           +S  +  ME       + +Q +RE   LRK ++ L+   +K
Sbjct: 715 TMRF------------TSTKLAQME------RENQQLEREKEELRKNVDLLKALGKK 753



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 84/372 (22%), Positives = 149/372 (40%), Gaps = 53/372 (14%)

Query: 52   LKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM--KLQI 109
            L+  +  LQ E   L+ +L+HL  +  T   ++ L L++    L E    L+    KLQ+
Sbjct: 1062 LERNNAALQAEKQLLKEQLQHLETQNVTFSSQI-LTLQKQSAFLQEHNTTLQTQTAKLQV 1120

Query: 110  ----LTPQKLELL-RAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEH 164
                L+ Q   L  +  + Q   T       +L  + E+  A Y  L  +H  L +  E 
Sbjct: 1121 ENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHER 1180

Query: 165  QKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKL 224
            Q  EY     E  I+  S +  L  + E    +L         +R   + + K  L ++ 
Sbjct: 1181 QSAEY-----EALIRQHSCLKTLHRNLELEHKEL--------GERHGDMLKRKAELEERE 1227

Query: 225  KGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKEL 284
            K L  E   L+ E+  +   +   QR               L  E    N    +L+ E 
Sbjct: 1228 KVLTTEREALQQEQRTNALAMGENQR---------------LRGELDRVNFLHHQLKGEY 1272

Query: 285  QSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNK-LEITDIKLET-----ARAKSELE 338
            +        L   L+ A+ E+N   ++  ELK  ++ ++I+  KL+      +R K  LE
Sbjct: 1273 EELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLE 1332

Query: 339  RERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEK 398
             E + + S++  L   N+           +L+E++ E   +    +++   KL  L+  K
Sbjct: 1333 EENHHLLSQIQLLSQQNQ-----------MLLEQNMENKEQYHEEQKQYIDKLNALRRHK 1381

Query: 399  LELENRLADLEK 410
             +LE ++ D  K
Sbjct: 1382 EKLEEKIMDQYK 1393


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score =  113 bits (283), Expect = 5e-25
 Identities = 142/655 (21%), Positives = 282/655 (43%), Gaps = 82/655 (12%)

Query: 33   KMLIDERLRCEHHKANYQTLKAEHT-----RLQNEHVKLQNELKHLFNEKQTQQ------ 81
            + L  E+   +H  A YQ  KA+H       L+N+   L+++L+ L    Q  Q      
Sbjct: 499  RQLEREKALLQHKNAEYQR-KADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKV 557

Query: 82   EKLQLLLEE--------------LRGELVEKTKDLEEMKLQ---------ILTPQKLELL 118
             +LQ  L+E              LR    E +K +++++           +L   KL+L 
Sbjct: 558  NQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLE 617

Query: 119  RA--QIQQELETPMRERFRN-------------LDEEVEKYRAVYNKLRYEHTFLKSEFE 163
            +    +Q  LE+  R+R                L+E+++  + +  K+  E   L+  F 
Sbjct: 618  KEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFT 677

Query: 164  HQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQK 223
              ++E + +  E  + Y+ ++ +   ++EE  ++     L   +K  E +   K    ++
Sbjct: 678  DLEKEKSNM--EIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKE 735

Query: 224  LKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKE 283
            ++    E   LK + EN   + E    +    L + Q  +  L  +K   N     L  +
Sbjct: 736  MEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLK 795

Query: 284  LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNK 343
            ++  +++     N L    +++NTL    K+LK  N   + ++K+   +  +EL +ER  
Sbjct: 796  IEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN-HLMEMKMNLEKQNAELRKERQD 854

Query: 344  IQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELEN 403
               ++  LQ   E  +     +K  + E   E   K +  KE   QK   LQDE+  L  
Sbjct: 855  ADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKEL-QQKKQELQDERDSLAA 913

Query: 404  RLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSV-RLKLQQQIVTIENAE 462
            +L ++   K + +   +S  ++    L   ++ +E+  KE+ +  + +L ++  TI + E
Sbjct: 914  QL-EITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 972

Query: 463  KEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQE---CRNFRSQAEK 519
            +             +L   V +LA  + +L N  + ++E + RLK E       ++Q EK
Sbjct: 973  ETNR----------TLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK 1022

Query: 520  AQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLK 579
             QL  E+TL+ + +  L E       I +R+E   +  +   R    +K+ + LH  +LK
Sbjct: 1023 -QLLTERTLKTQAVNKLAE-------IMNRKEPVKRGNDTDVRRK--EKENRKLHM-ELK 1071

Query: 580  RLQEKV--EVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSL 632
              +EK+  ++++ +KE  E + Q+     +  E    L  +  DI++  ++ ++L
Sbjct: 1072 SEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQAL 1126



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 119/546 (21%), Positives = 230/546 (42%), Gaps = 70/546 (12%)

Query: 138 DEEVEKYRAVYNKLRYEHTFLKSE---FEHQKEEYARILDEGKIKYESE-IARLEEDKEE 193
           D EV   R    ++R +H F K++   +++ +E  A ++ E     +S     +E+DK +
Sbjct: 335 DREVRLGRNGVEEIR-QHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGD 393

Query: 194 LR----------NQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEA 243
           +           NQL  +  T          RE + L       E +  + +  +E+ E 
Sbjct: 394 VETFPIPKAFVGNQLPFIGFT--------YYRENLLLSDSPSCRETDSIQSRKNEESQEI 445

Query: 244 QVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAER 303
           Q +    ++     EMQA    LE + +S N R E+  KEL+        + + L + ER
Sbjct: 446 Q-KKLYTLEEHLSNEMQAK-EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 503

Query: 304 EINTLSSKVKELKHSNKLEI---TDIKLETARAKSELERERNKIQSELDGLQSDNEILKA 360
           E   L  K  E +     E     +++ +    K +LE  + + Q+     +  N++ + 
Sbjct: 504 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQ 563

Query: 361 AVEHHKVLLVEKDREL-IRKVQAAKEEGYQKLVV----LQDEKLELENRLADLEKMKVEH 415
             E + +L  E D    +RK QA   +  Q+L      LQD+   LE     LEK  +  
Sbjct: 564 LDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINL 623

Query: 416 DVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNE----NSDL 471
               +SE+    ++   S++  ++ +  +  +   L+   + +   E EK +     +DL
Sbjct: 624 QSALESER---RDRTHGSEIINDL-QGRICGLEEDLKNGKILLAKVELEKRQLQERFTDL 679

Query: 472 KQQISSLQIQVT--------SLAQSE-------------NDLLNS-----NQMLKEMVER 505
           +++ S+++I +T        SL Q E             N +  S     ++ +KEM ++
Sbjct: 680 EKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKK 739

Query: 506 LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
           L +E R  + + E   LEAEK          + + K++E +  +++  N+    L     
Sbjct: 740 LLEE-RTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINE-LLKQKDVLNEDVRNLTLKIE 797

Query: 566 AQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFE-DYTRLQKRLKDIQR 624
            + +++ L +N LK   ++V  L+  +++L+ EN  L    +  E     L+K  +D   
Sbjct: 798 QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 857

Query: 625 RHNEFR 630
           +  E +
Sbjct: 858 QMKELQ 863



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 77/341 (22%), Positives = 150/341 (43%), Gaps = 47/341 (13%)

Query: 32   QKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL---L 88
            +K L  E       K N +   AE   L+ E      ++K L ++ + +Q    L    +
Sbjct: 824  EKQLKQENNHLMEMKMNLEKQNAE---LRKERQDADGQMKELQDQLEAEQYFSTLYKTQV 880

Query: 89   EELRGELVEKTK----------DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLD 138
             EL+ E  EKTK          +L++ +  +    ++ L +A  +Q   +   E++ +L+
Sbjct: 881  RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940

Query: 139  EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL 198
            +E         ++   H   K E   +K+     L+E      S++A L  +KEEL N+L
Sbjct: 941  KEKIMKELEIKEMMARH---KQELT-EKDATIASLEETNRTLTSDVANLANEKEELNNKL 996

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
             +V         EQL+R        LK  E   A +KA+ E         +   V +LAE
Sbjct: 997  KDVQ--------EQLSR--------LKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAE 1040

Query: 259  M----QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKE 314
            +    +   R  + + +       +L  EL+S  E+   L  ++ K ++E+N + +++ E
Sbjct: 1041 IMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREK---LTQQMIKYQKELNEMQAQIAE 1097

Query: 315  LKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDN 355
                +++ I ++++      S++E+ R+++Q+   GL S +
Sbjct: 1098 ---ESQIRI-ELQMTLDSKDSDIEQLRSQLQALHIGLDSSS 1134


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  112 bits (280), Expect = 1e-24
 Identities = 160/719 (22%), Positives = 297/719 (41%), Gaps = 87/719 (12%)

Query: 32   QKMLIDERLRCEHHKANYQTLKAEHTRLQ-NEHVKLQNELKHLFNEKQTQQEKLQLLLEE 90
            Q+ L  E+L  +  +     LK      Q  E V    EL+H  ++ + Q ++ Q L + 
Sbjct: 440  QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499

Query: 91   LRGELVEKTKDLEEMKLQI-LTPQKLELLRAQIQQELET-----PMRERFRNLDEEVEKY 144
               +L E   DLE++  QI    QK++ L A +Q+  E        RE      +  E  
Sbjct: 500  TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559

Query: 145  RAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRN-------- 196
             AV N+L+ ++  L+ +     E+     +  K   E+   +++E K  LR         
Sbjct: 560  TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619

Query: 197  ----QLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
                  LN  L +  ++V QL  +     + L   EA     +A+ +N     +NA + +
Sbjct: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679

Query: 253  VRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKV 312
             ++L ++   +  + A+ Q       +LE  L+   E+   L  K  + E +I  L +  
Sbjct: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739

Query: 313  KELKHSNKLEI----------TDIKLETARAKSELERERNKIQSELDGLQSDNEILKA-- 360
             E+K S +  +          TD++L       +LE E+  + S    LQ  +E L++  
Sbjct: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799

Query: 361  ----AVEHHKVLLVEKDRELIRKVQAAKEEGYQKL----VVLQDEKLELENRLADL---- 408
                  E  K +L +    L ++ +   EE   ++      LQ  K+E E  + +L    
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859

Query: 409  EKMKVEHDVWR--QSEKDQYEEKLRASQMAEEITRKELQ-----SVRLKLQQQIVTIENA 461
            +K+    D  +  +SE ++  +K +A+ +  E T KEL+      +   L++Q    ++ 
Sbjct: 860  DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNS---NQMLKEMVERLKQECRNFRSQAE 518
            EKEK  +  LK +++S+Q Q   L Q++N L  +    Q L+  +  LKQ     + Q E
Sbjct: 920  EKEKEASHQLKLELNSMQEQ---LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976

Query: 519  KAQ----------LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKE---KLQRAAI 565
              Q           E E  L+++  Q  +E     E+I+  +  Y +++E   +LQ    
Sbjct: 977  ALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036

Query: 566  AQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT------------ 613
             ++         LK ++EK+ +  A+++ +   NQ+ N+  +  E  T            
Sbjct: 1037 GRESELLATRQDLKSVEEKLSL--AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094

Query: 614  --RLQKRLKDIQ--RRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQE 668
              +LQ+R K +Q  ++    +   LV      A I  +  +    +  +      H  E
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE 1153



 Score =  111 bits (277), Expect = 3e-24
 Identities = 167/717 (23%), Positives = 311/717 (43%), Gaps = 84/717 (11%)

Query: 47  ANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQ----------------------QEKL 84
           A  Q+L+ +    Q E+  ++ ++K LF +K  Q                      ++K+
Sbjct: 135 AELQSLEQQLEEAQTENFNIK-QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193

Query: 85  QLLLEELRGELVE----KTKDLEEMKLQILTPQKLELLRAQIQQELETPMRER-FRNLDE 139
             L EEL  E       KT+ L+   ++ +   K EL++ Q   +  T  RER    L +
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253

Query: 140 EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLL 199
           E +K ++ Y       + L+SE     +E A  + E + K +S +  L +  + L   LL
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ-KLKSSVNELTQKNQTLTENLL 312

Query: 200 NV--DLTK----------DSKRVEQLAREKVYLCQKLKG-LEAEVAELKAEKENSEAQVE 246
               D TK            K ++    +K   CQ+L+  L A    L         + E
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 247 NAQRIQVRQLAEMQATVRSLEAE-KQSANLRAERLEKELQSSSEQNTFLINKLHKAEREI 305
             Q+++  +L+E++   + L+AE KQ    R E+ +  LQ  SE N  L +KL + ER++
Sbjct: 373 ATQKLK-EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ-LHSKLLETERQL 430

Query: 306 NTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSEL-DGLQSDNEILKAAVEH 364
                ++KE +  +  ++ D + + A  + +L R   +++ ++ +  +  +++ K   +H
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490

Query: 365 HKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKD 424
            +   ++  +    K++ A+ +  Q L  + D+  +++N  A L+K K    +  +  +D
Sbjct: 491 QEQQALQ--QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548

Query: 425 QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQ----------- 473
            Y  K++A +  E     +LQ     LQ+Q+  +   EK KN++   KQ           
Sbjct: 549 LY-AKIQAGE-GETAVLNQLQEKNHTLQEQVTQL--TEKLKNQSESHKQAQENLHDQVQE 604

Query: 474 ---QISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE-KAQLEAEKTLE 529
               + + Q +V SL  S N+L   N  L E  E++ Q     +++ E     EA KT +
Sbjct: 605 QKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661

Query: 530 EKQIQWLEEKHKLHERITDREEKYNQAKEKL-QRAAIAQKKRK--SLHENKLKRLQEKVE 586
              +Q           + D++++ N+   +L Q  A  Q K++  S  E+ LK  +EK  
Sbjct: 662 RADLQ--NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719

Query: 587 VLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHN-----EFRSLILVPNMPPT 641
            LE K EELE + + L   ++  E     ++ L+D+Q++       E R+  L   +   
Sbjct: 720 SLEQKTEELEGQIKKLEADSL--EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777

Query: 642 ASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGS 698
             I  VS     +    E       +  + + E  +L++  E L    + Q EEL +
Sbjct: 778 KEI--VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 137/589 (23%), Positives = 266/589 (45%), Gaps = 63/589 (10%)

Query: 24   LTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEK 83
            LT  + E Q +  D     +  K  ++ L         E  K++ E + L  E  T ++K
Sbjct: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861

Query: 84   LQLLLEELRGELVEKTKDLEEMKLQILTPQKL-ELLRAQIQQELETPMRERFRNLDEEVE 142
            L  + + L+    E  K+ ++ K  IL  +K  + L+ Q+Q ++E  ++E+ + L + +E
Sbjct: 862  LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ-KELKKSLE 920

Query: 143  KYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL---- 198
            K +   ++L+ E   ++ +   Q +   +  ++ + + +  I  L++  E+ + Q+    
Sbjct: 921  KEKEASHQLKLELNSMQEQLI-QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979

Query: 199  --LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQL 256
              L + + + ++   +L ++     Q+L   + +++ L+   E S+   +  Q     + 
Sbjct: 980  GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039

Query: 257  AEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELK 316
            +E+ AT + L++ ++  +L  E L         QN  LI +L  A+  +   S+K ++  
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-LIQELKTAKATLEQDSAKKEQQL 1098

Query: 317  HSNKLEITDIKLETARAKSELERERNKIQSELDGLQ--SDNEILKAAVEHHKVLLVEKDR 374
                  + DI+ E +  + EL  E++K+ +E++ ++   + EI K   E     L     
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEE-----LKSHKL 1152

Query: 375  ELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSE-KDQYEEKLRAS 433
            E I+++   K+    K +++Q +KLEL+ + AD  K  VE +   Q   KDQ +++    
Sbjct: 1153 ESIKEITNLKDA---KQLLIQ-QKLELQGK-ADSLKAAVEQEKRNQQILKDQVKKE---- 1203

Query: 434  QMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLL 493
               EE  +KE      KL  +I   E   K+  EN       + L +Q+T+L ++   + 
Sbjct: 1204 ---EEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE------AKLTMQITALNENLGTVK 1254

Query: 494  NSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
               Q  +  V  L+++  + R   E A LEA  T++  Q    +E+  L ER    E + 
Sbjct: 1255 KEWQSSQRRVSELEKQTDDLRG--EIAVLEA--TVQNNQ----DERRALLERCLKGEGEI 1306

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVL 602
                EKLQ               K+  LQ K++   A  +EL  ENQ L
Sbjct: 1307 ----EKLQ--------------TKVLELQRKLDNTTAAVQELGRENQSL 1337



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 161/673 (23%), Positives = 288/673 (42%), Gaps = 135/673 (20%)

Query: 50   QTLKAEHTRLQNEHVKLQNELKH---LFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMK 106
            Q L    T+L     KLQ++ +H   L +  +  +EK  L LE+   EL  + K LE   
Sbjct: 681  QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADS 739

Query: 107  LQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYE------------ 154
            L++   ++  L   Q Q++L T +  R   L +++E  + + +  R +            
Sbjct: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799

Query: 155  HTFLKSEFEHQ--KEEYARILDEGKIKYE----------SEIARLEEDKEELRNQLLNVD 202
                K E E Q  K+++  +  E KI++E          +E+ +++ +KE L  +L  V 
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859

Query: 203  LTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL----KAEKENSEAQVENAQRIQVRQLAE 258
              K SK  + L   K    ++ +  +A + +L    K  K   + Q+EN        L E
Sbjct: 860  -DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT-------LKE 911

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +   +SLE EK++++    +L+ EL S  EQ     N L + E+E   L   + ELK S
Sbjct: 912  QKELKKSLEKEKEASH----QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967

Query: 319  N---KLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLV----E 371
            +   K +I  ++ E   A  +     NK+Q +L   Q+  E+   A E  K+ ++    E
Sbjct: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLT--QAAQEL---AAEKEKISVLQNNYE 1022

Query: 372  KDRELIRKVQA---AKEEGY-----------QKLVVLQDEKLELENRLADLEKMKVEHDV 417
            K +E  +++Q+    +E              +KL + Q++ +   N++ +  K+  E   
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT 1082

Query: 418  WRQS-------EKDQYEEKLRASQMAEE---ITRKELQSVRLKL---------QQQIVTI 458
             + +       ++ Q +E+ +A Q  ++   +  KEL + + KL         Q++ +T 
Sbjct: 1083 AKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142

Query: 459  ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE 518
             N E + ++   +K+ I++L+     L Q + +L      LK  VE+ K+  +  + Q +
Sbjct: 1143 LNEELKSHKLESIKE-ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201

Query: 519  KAQLEAEKTLEEKQIQWLEE---------KH-----KLHERITDREEKYNQAKEKLQ--- 561
            K + E +K   EK+ +   E         KH     KL  +IT   E     K++ Q   
Sbjct: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261

Query: 562  -------------RAAIA---------QKKRKSLHENKLK------RLQEKVEVLEAKKE 593
                         R  IA         Q +R++L E  LK      +LQ KV  L+ K +
Sbjct: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321

Query: 594  ELETENQVLNRQN 606
                  Q L R+N
Sbjct: 1322 NTTAAVQELGREN 1334


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  112 bits (279), Expect = 2e-24
 Identities = 139/629 (22%), Positives = 286/629 (45%), Gaps = 79/629 (12%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
            E +K  +DE+L+ +  + +    K E  +     ++LQ ++K L       Q +++ L E
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--IQLQKKIKEL-------QARIEELEE 1126

Query: 90   ELRGELVEKTK----------DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE 139
            E+  E   + K          +LEE+  ++         + ++ ++ E   ++  R+L+E
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 140  EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLL 199
               ++ A    LR +H    +E   Q +   R+             +LE++K E++ ++ 
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-----------KLEKEKSEMKMEID 1235

Query: 200  NVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVEN--AQRIQV---- 253
            ++     +  VE +++ K  L +  + LE +++ELK+++E  +  + +  AQR ++    
Sbjct: 1236 DL-----ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES 1290

Query: 254  ----RQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLS 309
                RQL E +A V  L   KQ+   + E L+++L+   +    L + L  +  + + L 
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350

Query: 310  SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE-HHKVL 368
             + +E + S        +L+ A +K+  E  + + + E D +Q   E+ +A  +   ++ 
Sbjct: 1351 EQYEEEQESK------AELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1404

Query: 369  LVEKDRELIRKVQAAKEEGYQKLV-VLQDEKLELEN---RLADLEKMKVEHD----VWRQ 420
              E+  E +    A+ E+  Q+L   ++D  L++E      A L+K +   D     W+Q
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 421  SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
              ++ + E L ASQ        EL  ++   ++   +++  E  K EN +L+Q+IS L  
Sbjct: 1465 KCEETHAE-LEASQKEARSLGTELFKIKNAYEE---SLDQLETLKRENKNLQQEISDLTE 1520

Query: 481  QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
            Q+    +  ++L    + +K+ VE+ K E +    +AE +    E  +   Q++  + K 
Sbjct: 1521 QIAEGGKRIHEL----EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS 1576

Query: 541  KLHERITDREEKYNQAKEKLQRAAIAQKKRKSL-----HENKLKRLQEKVEVLEAKKEEL 595
            ++  +I +++E+ +Q K    R  I +  + +L       N   RL++K   +E    E+
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIR--IVESMQSTLDAEIRSRNDAIRLKKK---MEGDLNEM 1631

Query: 596  ETENQVLNRQNV-PFEDYTRLQKRLKDIQ 623
            E +    NR       +Y   Q  LKD Q
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQ 1660



 Score =  102 bits (255), Expect = 9e-22
 Identities = 124/570 (21%), Positives = 260/570 (45%), Gaps = 74/570 (12%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K  +Q +K E  + + +  +L+ ++  L  EK   Q ++Q   E L  +  E+   L + 
Sbjct: 859  KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL-ADAEERCDQLIKT 917

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFE-H 164
            K+Q+    K    RA+ ++E+   +  + R L++E  + +   + L  E T  K E E H
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--ELTLAKVEKEKH 975

Query: 165  QKEEYARILDEGKIKYESEIARLEEDKEELR--NQLLNVDLTKDSKRVEQLAREKVYLCQ 222
              E   + L E     +  IA+L ++K+ L+  +Q    DL  +  +V  L + K+ L Q
Sbjct: 976  ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035

Query: 223  KLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEK 282
            ++  LE  +     +++     +E A+R     L   Q ++  +E EKQ  + + ++ E 
Sbjct: 1036 QVDDLEGSL----EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 283  E---LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELER 339
            E   LQS  E    L  +L K   +I  L ++++EL+        +I+ E A ++++ E+
Sbjct: 1092 EISNLQSKIEDEQALGIQLQK---KIKELQARIEELEE-------EIEAERA-SRAKAEK 1140

Query: 340  ERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL 399
            +R+ +  EL+                         E+  +++ A      ++ + +  + 
Sbjct: 1141 QRSDLSRELE-------------------------EISERLEEAGGATSAQIEMNKKREA 1175

Query: 400  ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIE 459
            E +    DLE+  ++H+    + + ++ + +  +++ E+I    LQ V+ KL        
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV--AELGEQI--DNLQRVKQKL-------- 1223

Query: 460  NAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRS---- 515
              EKEK   S++K +I  L   V ++++++ +L    + L++ +  LK +    +     
Sbjct: 1224 --EKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 516  -QAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLH 574
              A++ +L+ E     +Q   L+EK  L  +++  ++ + Q  E+L+R    + K K+  
Sbjct: 1279 LTAQRGRLQTESGEFSRQ---LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335

Query: 575  ENKLKRLQEKVEVLEAKKEELETENQVLNR 604
             + L+  +   ++L  + EE +     L R
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKAELQR 1365



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 163/775 (21%), Positives = 323/775 (41%), Gaps = 144/775 (18%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHT------------------RLQNEHVKLQNE 69
            ++EFQKM  D       H+A   TL+ +H                   +L+ E  +++ E
Sbjct: 1174 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1233

Query: 70   LKHLFNEKQTQQ------EKLQLLLEELRGELVEKTKDLEEMKL-QILTPQK-------- 114
            +  L +  +T        EK+   LE+   EL  K+K+ E+ +L   LT Q+        
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSEL--KSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 115  --------LELLRAQI---QQELETPMRERFRNLDEEVEKYRAVYNKL---RYEHTFLKS 160
                     E L +Q+   +Q     + E  R L+EE++   A+ + L   R++   L+ 
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351

Query: 161  EFEHQKEEYARI----------LDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            ++E ++E  A +          + + + KYE++  +  E+ EE + +L    L    + V
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ-RLQAAEEHV 1410

Query: 211  EQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQ---VENAQRIQVRQLAEMQATVRSLE 267
            E +  +   L +  + L+ EV +L  + E + A    ++  QR   + LAE +       
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470

Query: 268  AEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIK 327
            AE +++   A  L  EL          +++L   +RE   L  ++ +L        T+  
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL--------TEQI 1522

Query: 328  LETARAKSELERERNKIQSELDGLQSDNEILKAAVEHH--KVLLVEKD-----RELIRKV 380
             E  +   ELE+ + +++ E   LQ+  E  +A++EH   K+L ++ +      E+ RK+
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582

Query: 381  QAAKEE------GYQKLVVLQDEKLELENRL------------ADLEKMKVEHDV----- 417
                EE       + ++V      L+ E R              DL +M+++ +      
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642

Query: 418  ------WRQSE---KD---QYEEKLRASQMAEE---ITRKELQSVRLKLQQQIVTIENAE 462
                  +R ++   KD     ++ LR+ +  +E   +  +    ++ ++++   T+E  E
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702

Query: 463  KEKN----ENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE 518
            + +     E  D  +++  L  Q TSL  ++  L      ++  +E + QE RN   +A+
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762

Query: 519  KAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKL 578
            KA  +A    EE     L+++      +   ++   Q  + L      Q +     +  L
Sbjct: 1763 KAITDAAMMAEE-----LKKEQDTSAHLERMKKNMEQTVKDL------QLRLDEAEQLAL 1811

Query: 579  KRLQEKVEVLEAKKEELETENQVLNRQNV-PFEDYTRLQKRLKDIQRRHNEFRSLIL-VP 636
            K  +++++ LEA+  ELE E +   ++N    +   + ++R+K++  +  E R  IL + 
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQ 1871

Query: 637  NMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
            ++         S++  A              EEQ    L+  RK   ELE  + +
Sbjct: 1872 DLVDKLQAKVKSYKRQA-----------EEAEEQSNTNLAKFRKLQHELEEAEER 1915



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 98/479 (20%), Positives = 204/479 (42%), Gaps = 58/479 (12%)

Query: 22   SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQ 81
            + L   Q  F K+L + + +CE   A  +  + E   L  E  K++N     + E   Q 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA----YEESLDQL 1501

Query: 82   EKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQE---LETPMRERFRNLD 138
            E L+   + L+ E+ + T+ + E   +I    +LE ++ Q++QE   L+  + E   +L+
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRI---HELEKIKKQVEQEKCELQAALEEAEASLE 1558

Query: 139  EEVEKYRAVYNKLRYEHTFLK-------SEFEHQKEEYARILD------EGKIKYESEIA 185
             E  K   +  +L    + +         E +  K  + RI++      + +I+  ++  
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618

Query: 186  RLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE-LKAEKENSE-- 242
            RL++  E   N++  + L   ++   +  R        LK  +  + + L+++++  E  
Sbjct: 1619 RLKKKMEGDLNEM-EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL 1677

Query: 243  AQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAE 302
            A VE    +   ++ E++AT+   E  ++ A        + +Q    QNT LIN   K E
Sbjct: 1678 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737

Query: 303  REINTLSSKVKEL-------KHSNKLEITDIKLETARAKSE------LERERNKIQSELD 349
             +I+ +  +++++       +   K  ITD  +     K E      LER +  ++  + 
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 350  GLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLE 409
             LQ         ++  + L ++  ++ I+K++A   E       L+ E    + R A+  
Sbjct: 1798 DLQ-------LRLDEAEQLALKGGKKQIQKLEARVRE-------LEGEVESEQKRNAEAV 1843

Query: 410  KMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNEN 468
            K   +H+   +    Q EE  +     +++  K    ++ K++      E AE++ N N
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDK----LQAKVKSYKRQAEEAEEQSNTN 1898



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 42/220 (19%), Positives = 92/220 (41%), Gaps = 28/220 (12%)

Query: 499  LKEMVERLKQECRNFRSQAEKAQLEAEKT------------LEEKQIQWLEEKHKLHERI 546
            L +++ R +  CR F ++ E  ++   +             +  K   W++   K+   +
Sbjct: 787  LAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLL 846

Query: 547  TDREEKYNQA--KEKLQRA----AIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600
               E +   A  KE+ Q+     A ++ KRK L E  +  L+EK ++    + E E    
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 601  VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAM---VPS 657
               R +   +   +L+ ++K++  R  +   +    N   TA    +  + S +   +  
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEI----NAELTAKKRKLEDECSELKKDIDD 962

Query: 658  MELPFPPHMQEEQH--QRELSLLRKRLEELETTQRKQLEE 695
            +EL     +++E+H  + ++  L + +  L+ T  K  +E
Sbjct: 963  LELTL-AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  112 bits (279), Expect = 2e-24
 Identities = 139/629 (22%), Positives = 286/629 (45%), Gaps = 79/629 (12%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
            E +K  +DE+L+ +  + +    K E  +     ++LQ ++K L       Q +++ L E
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--IQLQKKIKEL-------QARIEELEE 1126

Query: 90   ELRGELVEKTK----------DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE 139
            E+  E   + K          +LEE+  ++         + ++ ++ E   ++  R+L+E
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 140  EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLL 199
               ++ A    LR +H    +E   Q +   R+             +LE++K E++ ++ 
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-----------KLEKEKSEMKMEID 1235

Query: 200  NVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVEN--AQRIQV---- 253
            ++     +  VE +++ K  L +  + LE +++ELK+++E  +  + +  AQR ++    
Sbjct: 1236 DL-----ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES 1290

Query: 254  ----RQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLS 309
                RQL E +A V  L   KQ+   + E L+++L+   +    L + L  +  + + L 
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350

Query: 310  SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE-HHKVL 368
             + +E + S        +L+ A +K+  E  + + + E D +Q   E+ +A  +   ++ 
Sbjct: 1351 EQYEEEQESK------AELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1404

Query: 369  LVEKDRELIRKVQAAKEEGYQKLV-VLQDEKLELEN---RLADLEKMKVEHD----VWRQ 420
              E+  E +    A+ E+  Q+L   ++D  L++E      A L+K +   D     W+Q
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 421  SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQI 480
              ++ + E L ASQ        EL  ++   ++   +++  E  K EN +L+Q+IS L  
Sbjct: 1465 KCEETHAE-LEASQKEARSLGTELFKIKNAYEE---SLDQLETLKRENKNLQQEISDLTE 1520

Query: 481  QVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
            Q+    +  ++L    + +K+ VE+ K E +    +AE +    E  +   Q++  + K 
Sbjct: 1521 QIAEGGKRIHEL----EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS 1576

Query: 541  KLHERITDREEKYNQAKEKLQRAAIAQKKRKSL-----HENKLKRLQEKVEVLEAKKEEL 595
            ++  +I +++E+ +Q K    R  I +  + +L       N   RL++K   +E    E+
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIR--IVESMQSTLDAEIRSRNDAIRLKKK---MEGDLNEM 1631

Query: 596  ETENQVLNRQNV-PFEDYTRLQKRLKDIQ 623
            E +    NR       +Y   Q  LKD Q
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQ 1660



 Score =  102 bits (255), Expect = 9e-22
 Identities = 124/570 (21%), Positives = 260/570 (45%), Gaps = 74/570 (12%)

Query: 46   KANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM 105
            K  +Q +K E  + + +  +L+ ++  L  EK   Q ++Q   E L  +  E+   L + 
Sbjct: 859  KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL-ADAEERCDQLIKT 917

Query: 106  KLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFE-H 164
            K+Q+    K    RA+ ++E+   +  + R L++E  + +   + L  E T  K E E H
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--ELTLAKVEKEKH 975

Query: 165  QKEEYARILDEGKIKYESEIARLEEDKEELR--NQLLNVDLTKDSKRVEQLAREKVYLCQ 222
              E   + L E     +  IA+L ++K+ L+  +Q    DL  +  +V  L + K+ L Q
Sbjct: 976  ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035

Query: 223  KLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEK 282
            ++  LE  +     +++     +E A+R     L   Q ++  +E EKQ  + + ++ E 
Sbjct: 1036 QVDDLEGSL----EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 283  E---LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELER 339
            E   LQS  E    L  +L K   +I  L ++++EL+        +I+ E A ++++ E+
Sbjct: 1092 EISNLQSKIEDEQALGIQLQK---KIKELQARIEELEE-------EIEAERA-SRAKAEK 1140

Query: 340  ERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL 399
            +R+ +  EL+                         E+  +++ A      ++ + +  + 
Sbjct: 1141 QRSDLSRELE-------------------------EISERLEEAGGATSAQIEMNKKREA 1175

Query: 400  ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIE 459
            E +    DLE+  ++H+    + + ++ + +  +++ E+I    LQ V+ KL        
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV--AELGEQI--DNLQRVKQKL-------- 1223

Query: 460  NAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRS---- 515
              EKEK   S++K +I  L   V ++++++ +L    + L++ +  LK +    +     
Sbjct: 1224 --EKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 516  -QAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLH 574
              A++ +L+ E     +Q   L+EK  L  +++  ++ + Q  E+L+R    + K K+  
Sbjct: 1279 LTAQRGRLQTESGEFSRQ---LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335

Query: 575  ENKLKRLQEKVEVLEAKKEELETENQVLNR 604
             + L+  +   ++L  + EE +     L R
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKAELQR 1365



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 163/775 (21%), Positives = 323/775 (41%), Gaps = 144/775 (18%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHT------------------RLQNEHVKLQNE 69
            ++EFQKM  D       H+A   TL+ +H                   +L+ E  +++ E
Sbjct: 1174 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1233

Query: 70   LKHLFNEKQTQQ------EKLQLLLEELRGELVEKTKDLEEMKL-QILTPQK-------- 114
            +  L +  +T        EK+   LE+   EL  K+K+ E+ +L   LT Q+        
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSEL--KSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 115  --------LELLRAQI---QQELETPMRERFRNLDEEVEKYRAVYNKL---RYEHTFLKS 160
                     E L +Q+   +Q     + E  R L+EE++   A+ + L   R++   L+ 
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351

Query: 161  EFEHQKEEYARI----------LDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            ++E ++E  A +          + + + KYE++  +  E+ EE + +L    L    + V
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ-RLQAAEEHV 1410

Query: 211  EQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQ---VENAQRIQVRQLAEMQATVRSLE 267
            E +  +   L +  + L+ EV +L  + E + A    ++  QR   + LAE +       
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470

Query: 268  AEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIK 327
            AE +++   A  L  EL          +++L   +RE   L  ++ +L        T+  
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL--------TEQI 1522

Query: 328  LETARAKSELERERNKIQSELDGLQSDNEILKAAVEHH--KVLLVEKD-----RELIRKV 380
             E  +   ELE+ + +++ E   LQ+  E  +A++EH   K+L ++ +      E+ RK+
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582

Query: 381  QAAKEE------GYQKLVVLQDEKLELENRL------------ADLEKMKVEHDV----- 417
                EE       + ++V      L+ E R              DL +M+++ +      
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642

Query: 418  ------WRQSE---KD---QYEEKLRASQMAEE---ITRKELQSVRLKLQQQIVTIENAE 462
                  +R ++   KD     ++ LR+ +  +E   +  +    ++ ++++   T+E  E
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702

Query: 463  KEKN----ENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAE 518
            + +     E  D  +++  L  Q TSL  ++  L      ++  +E + QE RN   +A+
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762

Query: 519  KAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKL 578
            KA  +A    EE     L+++      +   ++   Q  + L      Q +     +  L
Sbjct: 1763 KAITDAAMMAEE-----LKKEQDTSAHLERMKKNMEQTVKDL------QLRLDEAEQLAL 1811

Query: 579  KRLQEKVEVLEAKKEELETENQVLNRQNV-PFEDYTRLQKRLKDIQRRHNEFRSLIL-VP 636
            K  +++++ LEA+  ELE E +   ++N    +   + ++R+K++  +  E R  IL + 
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQ 1871

Query: 637  NMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
            ++         S++  A              EEQ    L+  RK   ELE  + +
Sbjct: 1872 DLVDKLQAKVKSYKRQA-----------EEAEEQSNTNLAKFRKLQHELEEAEER 1915



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 98/479 (20%), Positives = 204/479 (42%), Gaps = 58/479 (12%)

Query: 22   SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQ 81
            + L   Q  F K+L + + +CE   A  +  + E   L  E  K++N     + E   Q 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA----YEESLDQL 1501

Query: 82   EKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQE---LETPMRERFRNLD 138
            E L+   + L+ E+ + T+ + E   +I    +LE ++ Q++QE   L+  + E   +L+
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRI---HELEKIKKQVEQEKCELQAALEEAEASLE 1558

Query: 139  EEVEKYRAVYNKLRYEHTFLK-------SEFEHQKEEYARILD------EGKIKYESEIA 185
             E  K   +  +L    + +         E +  K  + RI++      + +I+  ++  
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618

Query: 186  RLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE-LKAEKENSE-- 242
            RL++  E   N++  + L   ++   +  R        LK  +  + + L+++++  E  
Sbjct: 1619 RLKKKMEGDLNEM-EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL 1677

Query: 243  AQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAE 302
            A VE    +   ++ E++AT+   E  ++ A        + +Q    QNT LIN   K E
Sbjct: 1678 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737

Query: 303  REINTLSSKVKEL-------KHSNKLEITDIKLETARAKSE------LERERNKIQSELD 349
             +I+ +  +++++       +   K  ITD  +     K E      LER +  ++  + 
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 350  GLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLE 409
             LQ         ++  + L ++  ++ I+K++A   E       L+ E    + R A+  
Sbjct: 1798 DLQ-------LRLDEAEQLALKGGKKQIQKLEARVRE-------LEGEVESEQKRNAEAV 1843

Query: 410  KMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNEN 468
            K   +H+   +    Q EE  +     +++  K    ++ K++      E AE++ N N
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDK----LQAKVKSYKRQAEEAEEQSNTN 1898



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 42/220 (19%), Positives = 92/220 (41%), Gaps = 28/220 (12%)

Query: 499  LKEMVERLKQECRNFRSQAEKAQLEAEKT------------LEEKQIQWLEEKHKLHERI 546
            L +++ R +  CR F ++ E  ++   +             +  K   W++   K+   +
Sbjct: 787  LAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLL 846

Query: 547  TDREEKYNQA--KEKLQRA----AIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQ 600
               E +   A  KE+ Q+     A ++ KRK L E  +  L+EK ++    + E E    
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 601  VLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAM---VPS 657
               R +   +   +L+ ++K++  R  +   +    N   TA    +  + S +   +  
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEI----NAELTAKKRKLEDECSELKKDIDD 962

Query: 658  MELPFPPHMQEEQH--QRELSLLRKRLEELETTQRKQLEE 695
            +EL     +++E+H  + ++  L + +  L+ T  K  +E
Sbjct: 963  LELTL-AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score =  112 bits (279), Expect = 2e-24
 Identities = 133/584 (22%), Positives = 251/584 (42%), Gaps = 63/584 (10%)

Query: 48   NYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKL 107
            N Q +K E  R++        EL+   NEK  +   LQ  LEE  GEL +  ++L ++K+
Sbjct: 636  NQQNIKEERERMRAN----LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKM 691

Query: 108  QILTPQ----KLELLRAQIQQELETPMRERFRN---LDEEV--------------EKYRA 146
            +    Q     L+   +++  EL++  R   R    L EE+              E+   
Sbjct: 692  EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751

Query: 147  VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKD 206
            +  K   E T LK   + +   + + +D+ K +Y++E+  L E  EE    +  +    +
Sbjct: 752  LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811

Query: 207  SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQL----AEMQAT 262
            +   +Q   E      ++K L+ E  +L+   E  E +V   QR Q+  L    A+ + T
Sbjct: 812  TSEQDQAGTE-----MRVKLLQEENEKLQGRSEELERRVAQLQR-QIEDLKGDEAKAKET 865

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            ++  E E +          KE + +      L N+L  A+  ++  + + K+L    K E
Sbjct: 866  LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK-E 924

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
             ++ K +  R K+E+E ER  +   ++ LQ +   +   VE  +   +E   +L    + 
Sbjct: 925  ESEQKEQLRRLKNEMENERWHLGKTIEKLQKE---MADIVEASRTSTLELQNQLDEYKEK 981

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + E  +    L+++ LE E       KM        Q E    EE+LR  Q A++    
Sbjct: 982  NRRELAEMQRQLKEKTLEAEKSRLTAMKM--------QDEMRLMEEELRDYQRAQD---- 1029

Query: 443  ELQSVRLKLQQQIVTIE-NAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKE 501
            E  + R  L+Q +  +E   E + +   D  + +  ++ +V+ L     +  N++ +L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089

Query: 502  MVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQ 561
             + R +++    R++  + +  A + LE  +I    +   L  RI   E  Y  +KE L 
Sbjct: 1090 RISRSREQMEQLRNELLQ-ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL- 1147

Query: 562  RAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQ 605
               + Q       E ++  L++++E  E  +  L+  N+ L R+
Sbjct: 1148 ---VVQM------EARIAELEDRLESEERDRANLQLSNRRLERK 1182



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 127/577 (22%), Positives = 267/577 (46%), Gaps = 85/577 (14%)

Query: 82   EKLQLLLEELRGEL---------VEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRE 132
            EK+Q L     G             + KDL E K       KL +  A++Q++L+  ++ 
Sbjct: 583  EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQK------SKLTIEVAELQRQLQLEVKN 636

Query: 133  RFRNLDEEVEKYRAVYNKLRYEH-------TFLKSEFEHQKEEYARILDE------GKIK 179
            + +N+ EE E+ RA   +LR +H       + L+   E  + E  + L+E       + +
Sbjct: 637  Q-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQ 695

Query: 180  YESEIARLEEDKEELRNQLLNVDLTKDSKR---VEQLAREKVYLCQKL----------KG 226
            +++EI  L++   E+ ++L +   ++D ++   +E+L + K  L   L          + 
Sbjct: 696  HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755

Query: 227  LEAEVAELK-AEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAER--LEKE 283
             E E+  LK A KE   +  +   +++ +  AE+QA   S+E   ++  + A R    ++
Sbjct: 756  RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815

Query: 284  LQSSSEQNTFLINKLH-KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
             Q+ +E    L+ + + K +     L  +V +L+     +I D+K + A+AK  L++   
Sbjct: 816  DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQR----QIEDLKGDEAKAKETLKKYEG 871

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE 402
            +I+   + L    +  K AV   + L  E +       Q  +E+  ++L     E+ E +
Sbjct: 872  EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ--KQLSEKLKEESEQK 929

Query: 403  NRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAE 462
             +L  L K ++E++ W   +  +  +K    +MA+ +      +  L+LQ Q+   E  E
Sbjct: 930  EQLRRL-KNEMENERWHLGKTIEKLQK----EMADIVEASRTST--LELQNQLD--EYKE 980

Query: 463  KEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQL 522
            K + E +++++Q+    ++      +E   L + +M  EM   +++E R+++   ++A  
Sbjct: 981  KNRRELAEMQRQLKEKTLE------AEKSRLTAMKMQDEM-RLMEEELRDYQRAQDEALT 1033

Query: 523  EA---EKTLEEKQIQWLEEKHKLHER---ITDREEKYNQAKEKLQRAAIAQKKRKSLHEN 576
            +    E+TL++ + +   + H   +R   +   E+K +Q + +L+     ++    L   
Sbjct: 1034 KRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE----ERNNSDLLSE 1089

Query: 577  KLKRLQEKVEVLE-------AKKEELETENQVLNRQN 606
            ++ R +E++E L        A +++LE +   L RQN
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 128/575 (22%), Positives = 242/575 (42%), Gaps = 87/575 (15%)

Query: 188  EEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLC----QKLKGLEAEVAELKAEKENSEA 243
            ++  EE   Q+L   L + S   +   + KV L     Q LK   A  A+   +  NS +
Sbjct: 548  QQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTS 607

Query: 244  QVENAQRIQVRQLAEMQATVRSLEAE-KQSANLRAER---------LEKELQSSSEQNTF 293
            +V++    + +   E+    R L+ E K   N++ ER         L  +     E+N+ 
Sbjct: 608  EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667

Query: 294  LINKLHKAEREINTLSS---KVKELKHSNKLEITDIKLETARAKSEL-------ERERNK 343
            L  +L ++E E+        +VK  +  ++ EI D++ + +    EL       +RE+  
Sbjct: 668  LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727

Query: 344  IQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELEN 403
            +  EL   + D + L  A E  + LL +++REL     A KE              E+ +
Sbjct: 728  LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE--------------EVSS 773

Query: 404  RLADLEKMKVEHDVWRQSEKDQYEEKLR-ASQMAEEITRKELQSVRLKLQQQIVTIENAE 462
               +++K+K ++D   Q+ ++  EE  +    +A      E      +++ +++  EN E
Sbjct: 774  HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN-E 832

Query: 463  KEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQ------ECRNFRSQ 516
            K +  + +L+++++ LQ Q+  L   + D   + + LK+    ++Q        R    +
Sbjct: 833  KLQGRSEELERRVAQLQRQIEDL---KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889

Query: 517  AEKAQLEAEKTLEEKQ---IQWLEEKHKLHERITDREEKYNQAK---------------- 557
            A  A+   E  LE  Q    Q  +E+ +L E++ +  E+  Q +                
Sbjct: 890  AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949

Query: 558  -EKLQR--AAIAQKKRKS-------LHENKLKRLQEKVEVLEAKKEE-LETENQVLNRQN 606
             EKLQ+  A I +  R S       L E K K  +E  E+    KE+ LE E   L    
Sbjct: 950  IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009

Query: 607  VPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHM 666
            +  ++   +++ L+D QR  +E  +L     +  T        ++ + +          M
Sbjct: 1010 MQ-DEMRLMEEELRDYQRAQDE--ALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 1066

Query: 667  QEEQHQRELSLLRKR-----LEELETTQRKQLEEL 696
            +++  Q E+ L  +R     L E  +  R+Q+E+L
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQL 1101



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 80/354 (22%), Positives = 162/354 (45%), Gaps = 31/354 (8%)

Query: 19   GGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ 78
            G  S  T  Q +  + L +E  + E  +     ++ E   L     KLQ E+  +    +
Sbjct: 906  GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965

Query: 79   TQQEKLQLLLEEL----RGELVEKTKDLEEMKLQILTPQKLELLRAQIQQEL---ETPMR 131
            T   +LQ  L+E     R EL E  + L+E  L+    +K  L   ++Q E+   E  +R
Sbjct: 966  TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEA---EKSRLTAMKMQDEMRLMEEELR 1022

Query: 132  ERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDK 191
            +  R  DE + K + +   L+     L+++  H K++ +R++ +     E ++++LE + 
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEAK-SHLKDDRSRLVKQ----MEDKVSQLEMEL 1077

Query: 192  EELRNQ--LLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQ 249
            EE RN   LL+  +++  +++EQL  E +      + LE +   L+ + ++ ++++ +  
Sbjct: 1078 EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH-- 1135

Query: 250  RIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLS 309
             ++    +  +  V  +EA       R   LE  L+S       L     + ER++  L 
Sbjct: 1136 -LEGSYRSSKEGLVVQMEA-------RIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187

Query: 310  SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE 363
             +V +      L +TD K + +     ++R+  + + E+D L+S  + L+  +E
Sbjct: 1188 MQVDD----EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  111 bits (277), Expect = 3e-24
 Identities = 121/549 (22%), Positives = 252/549 (45%), Gaps = 65/549 (11%)

Query: 53  KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTP 112
           K E  +L     +LQ E  HL  E Q+   KLQ  +EE   EL  +    +E K+     
Sbjct: 250 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE--NELWNRLNQQQEEKM----- 302

Query: 113 QKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARI 172
                 + +  QE E  ++E+   + E+ EK R    K+R +      E   +KEE  R 
Sbjct: 303 ----WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ-----EEMMWEKEEKMRR 353

Query: 173 LDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVA 232
            +E   + E ++ R EE   E   ++         +R E++  EK    +K++ LE ++ 
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKM---------RRQEEMMWEKE---EKIRELEEKMH 401

Query: 233 ELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNT 292
           E +  +E  E + E  +  +  +  E +A +   E + +    +    EK++    E   
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE--- 458

Query: 293 FLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ 352
               K+H+ E        K++E +   + E    + E    + E+ R++ K+  + + ++
Sbjct: 459 ----KIHEQE--------KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506

Query: 353 SDNEIL---KAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLE 409
              E +   +  +   +  + E++ ++ R+ +  +E   Q+ +  ++EK+  + ++ + E
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE---QEEMWREEEKMHEQEKIWEEE 563

Query: 410 KMKVEHD-VWRQSEKD--------QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTI-E 459
           K + + D +WRQ EK         + EEK+R  +   +   +++     K+++Q   I E
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE 623

Query: 460 NAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK 519
             EK + +   +++Q    Q Q   + + E  +    + ++E  E + ++    R Q +K
Sbjct: 624 QEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKK 683

Query: 520 AQLEAEKTLE-EKQIQWLEEK-HKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENK 577
            + + EK  E E+ +Q  EEK  +  E++ ++EEK  + +EK++R    Q+++    E +
Sbjct: 684 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR----QEEKMWEQEVR 739

Query: 578 LKRLQEKVE 586
           L++ +EK++
Sbjct: 740 LRQQEEKMQ 748



 Score =  107 bits (268), Expect = 3e-23
 Identities = 124/595 (20%), Positives = 269/595 (45%), Gaps = 54/595 (9%)

Query: 65  KLQNELKHLFNEKQTQQEKLQLLLEELRGE-----------------LVEKTKDLEEMKL 107
           K   EL+   +   TQ++K    +EEL  E                 L EK   L+E KL
Sbjct: 172 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE-KL 230

Query: 108 QILTPQKLEL------LRAQIQQ-ELETPMRERFRNLDEEVEKYRAVYNKLR--YEHTFL 158
           Q++  +K E+      L+ ++++ +L  P ++     D   ++ ++V  KL+   E   L
Sbjct: 231 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 290

Query: 159 KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNV-DLTKDSKRVEQLAREK 217
            +    Q+EE     +E   ++E +I   +E +E++R Q   + +  +  +R E++  EK
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKI---QEQEEKIREQEEKIREQEEKMRRQEEMMWEK 347

Query: 218 VYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEA----EKQSA 273
               ++ + +  E  E    +E    + E   R Q   + E +  +R LE     +++  
Sbjct: 348 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 407

Query: 274 NLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARA 333
               +R E+E     E+      K+ + E +I     K++E +     +   I  +    
Sbjct: 408 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467

Query: 334 KSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVV 393
           + E  +E+ ++  + + +    EI +   + H+        E IRK Q  K    ++ + 
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE------QEEKIRK-QEEKVWRQEEKIR 520

Query: 394 LQDEKL--ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKL 451
            Q+EK+  + E      EK++ + ++WR+ EK   +EK+      EE  R+E +    + 
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI-----WEEEKRQEQEDKMWRQ 575

Query: 452 QQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECR 511
           +++I   E  EK   +   +++Q    Q Q   + + E  +    + ++E  E+++++  
Sbjct: 576 EEKI--REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633

Query: 512 NFRSQAEKAQLEAEK--TLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKK 569
             R Q E  Q + EK    EEK  +  E+  +  E +  +EEK  + ++K++      ++
Sbjct: 634 KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693

Query: 570 RKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVP-FEDYTRLQKRLKDIQ 623
           ++ + + + +++ E+ E +  ++E+++ + + + RQ    +E   RL+++ + +Q
Sbjct: 694 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748



 Score =  101 bits (252), Expect = 2e-21
 Identities = 98/512 (19%), Positives = 240/512 (46%), Gaps = 36/512 (7%)

Query: 139 EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL 198
           EE+ K R   +   Y +T    E    KE+ A++ ++ ++  ESE + ++ + +EL+ +L
Sbjct: 196 EELTKERDALSLELYRNTITDEEL---KEKNAKLQEKLQL-VESEKSEIQLNVKELKRKL 251

Query: 199 LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
               L       +QL  E  +L ++L+ + A++     E E      +  +    RQ  +
Sbjct: 252 ERAKLLLPQ---QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308

Query: 259 MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
           +Q     ++ +++    + E++ ++ +    Q   +  K  K  R+   +  K ++++  
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368

Query: 319 NKL------------EITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK 366
            ++            E+   K E  R   E   E+ KI+ + +  Q + +I +      +
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428

Query: 367 VLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQY 426
              + +  E IR+ Q  K    +K +  Q+EK+  + ++ + EK + + ++WRQ EK   
Sbjct: 429 EAKMWRQEEKIRE-QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487

Query: 427 EEKL--RASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTS 484
           +E++  +  +M E+  +   Q  ++  Q++ +  E  EK + +   + +Q   ++ Q   
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR-EQEEKIREQEEKMWRQEEKIREQEEM 546

Query: 485 LAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH---- 540
             + E   ++  + + E  +R +QE + +R + +  + E +   +E++I+  EEK     
Sbjct: 547 WREEEK--MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQE 604

Query: 541 ----KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
               K  E+I ++EEK  + +EK++      ++++ + + + +++ E+ E +  ++E+++
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 664

Query: 597 TENQVLNRQNVPFEDYTRLQKRLKDIQRRHNE 628
            + + + RQ    E     +K++++ + +  E
Sbjct: 665 EQEETMWRQE---EKIREQEKKIREQEEKIRE 693



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 106/469 (22%), Positives = 214/469 (45%), Gaps = 47/469 (10%)

Query: 164 HQKEEYARILDEGKIKYESEIARLEEDKEELRNQ--LLNVDLTKDSKRVEQLAREKVYLC 221
           H   ++A  L++      ++  + +   EEL  +   L+++L +++   E+L  +   L 
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227

Query: 222 QKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLE 281
           +KL+ +E+E +E++   +  + ++E A+ +  +Q  + +A     E +  SA L+A+  E
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287

Query: 282 KEL-----QSSSEQNTFLINKLHKAEREINTLSSKVKEL---------KHSNKLEITDIK 327
            EL     Q   E+      K+ + E +I     K++E          K   + E+   K
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK 347

Query: 328 LETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEG 387
            E  R + E+  E+ +     + +  + E      E       EK REL  K+       
Sbjct: 348 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE----- 402

Query: 388 YQKLVVLQDEKLELENRLADLEK-MKVEHDVWRQSEK-DQYEEKLRASQ-----MAEEIT 440
            Q+ +  Q+EK + E ++ + EK  + E  +WRQ EK  + EEK+R  +       E+I 
Sbjct: 403 -QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461

Query: 441 RKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLK 500
            +E      K Q+Q   +   E++ +E  ++ +Q   +  Q   + + E  +    + ++
Sbjct: 462 EQEKIREEEKRQEQ-EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520

Query: 501 EMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQ-----WLEEKH--------KLHERIT 547
           E  E+++++      Q EK + + E   EE+++      W EEK         +  E+I 
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580

Query: 548 DREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELE 596
           ++EEK  + +EK++     Q++++   E K+ + +EK+   E K +E E
Sbjct: 581 EQEEKVWRQEEKIRE----QEEKRQEQEEKMWKQEEKIREQEEKIQEQE 625



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 98/408 (24%), Positives = 185/408 (45%), Gaps = 32/408 (7%)

Query: 235 KAEKENSEAQVENAQRIQVRQLAEMQAT-------VRSLEAEKQSANLRAERLEKELQSS 287
           +A +   EAQV    RI   Q  E+Q         V+ LE E +    R     K     
Sbjct: 119 EALRRELEAQVHTI-RILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL 177

Query: 288 SEQNTFLINKLHKAEREINTLSSKVKELK-HSNKLEITDIKLETARAKSELERERNKIQS 346
            +  + +  +  KA+R I  L+ +   L     +  ITD +L+   AK  L+ +   ++S
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK--LQEKLQLVES 235

Query: 347 ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
           E   +Q + + LK  +E  K+LL ++  +        + +     +  Q E+ EL NRL 
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL- 294

Query: 407 DLEKMKVEHDVWRQSEKDQ-YEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEK 465
                + E  +WRQ EK Q +EEK+   Q  EE  R++ + +R          E  EK +
Sbjct: 295 ---NQQQEEKMWRQEEKIQEWEEKI---QEQEEKIREQEEKIR----------EQEEKMR 338

Query: 466 NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAE 525
            +   + ++   ++ Q   + + E  +    +M+ E  E+++++      + EK +   E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398

Query: 526 KTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK-SLHENKLKRLQE 583
           K  E+++I+  EEK +  E+I ++E++  Q AK   Q   I +++ K    E K+ R +E
Sbjct: 399 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 458

Query: 584 KV-EVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFR 630
           K+ E  + ++EE   E + + RQ     +   + ++ + +  +  + R
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  111 bits (277), Expect = 3e-24
 Identities = 129/618 (20%), Positives = 273/618 (44%), Gaps = 57/618 (9%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
            E  K  +DERL+ +  +  Y  L+++    Q   ++ Q ++K L       Q +++ L E
Sbjct: 1071 ENDKQQLDERLKKKDFE--YCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEELEE 1121

Query: 90   ELRGELVEKTK----------DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE 139
            E+  E   + K          +LEE+  ++     +   + ++ ++ E    +  R+L+E
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE 1181

Query: 140  EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLL 199
               ++ A+   LR +H    +E   Q +   R+    K K E E +  + + ++L + + 
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRV----KQKLEKEKSEFKLEIDDLSSSME 1237

Query: 200  NVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEM 259
            +V  +K    +E++ R       + +G   E+    +E    +++++       RQL E 
Sbjct: 1238 SV--SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295

Query: 260  QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSN 319
            ++ V  L   KQ+   + E L+++L+  ++    L + L  +  + + L  + +E +   
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355

Query: 320  KLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRK 379
                 +++   ++A SE+ + R K   E D +Q   E+     E  K  L ++ ++   +
Sbjct: 1356 ----AELQRALSKANSEVAQWRTKY--ETDAIQRTEEL-----EEAKKKLAQRLQDSEEQ 1404

Query: 380  VQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKD------QYEEKLRAS 433
            V+A   +        Q  + E+E+ + D+E+         + +++      +++ K   S
Sbjct: 1405 VEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES 1464

Query: 434  QMAEEITRKELQSVRLKLQQQIVTIENA----EKEKNENSDLKQQISSLQIQVTSLAQSE 489
            Q   E + KE +S+  +L +     E A    E  K EN +L+Q+I+ L  Q+    ++ 
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524

Query: 490  NDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDR 549
            ++L  S    ++ +E  K + +    +AE A    E  +   Q++  + K ++  +I ++
Sbjct: 1525 HELEKS----RKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580

Query: 550  EEKYNQAKEKLQRAAIAQKKRKSLH---ENKLKRLQEKVEVLEAKKEELETENQVLNRQN 606
            +E+  Q K   QR     +          N+  RL++K   +E    E+E +    NRQ 
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKK---MEGDLNEIEIQLSHANRQA 1637

Query: 607  VPFEDYTR-LQKRLKDIQ 623
                 + R +Q +LKD Q
Sbjct: 1638 AETLKHLRSVQGQLKDTQ 1655



 Score =  105 bits (261), Expect = 2e-22
 Identities = 148/694 (21%), Positives = 304/694 (43%), Gaps = 71/694 (10%)

Query: 32   QKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKH---LFNEKQTQQEKLQLLL 88
            +  L + R + E  + +   L  + +RLQ E  +L  +L+    + ++    ++      
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313

Query: 89   EELRGELVEKTKDLEEMKLQILTPQK-LELLRAQIQQELE--TPMRERFRNLDEEVEKYR 145
            EEL+ +L E+ K    +   + + +   +LLR Q ++E E    ++      + EV ++R
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373

Query: 146  AVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYES---EIARLEEDKEELRNQLLNVD 202
              Y     + T    E E  K++ A+ L + + + E+   + A LE+ K+ L+ ++   D
Sbjct: 1374 TKYETDAIQRT---EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV--ED 1428

Query: 203  LTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENA---QRIQVRQLAEM 259
            L  D +R   LA     L +K +  +  +AE K + E S+A++E +    R    +L ++
Sbjct: 1429 LMVDVERANSLAAA---LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485

Query: 260  QATVRSLEAEKQSANLRAERLEKELQSSSEQ---NTFLINKLHKAEREINTLSSKVK--- 313
            +        + ++     + LE+E+   +EQ   N   I++L K+ ++I    + ++   
Sbjct: 1486 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545

Query: 314  -----ELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVL 368
                  L+H  + +I  I+LE  + KSE++R+  +   E++ L+ + +     ++     
Sbjct: 1546 EEAEAALEHE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604

Query: 369  LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQY-- 426
             V    E IR  +  K EG    + +Q   L   NR A  E +K    V  Q +  Q   
Sbjct: 1605 EVRSRNEAIRLKK--KMEGDLNEIEIQ---LSHANRQA-AETLKHLRSVQGQLKDTQLHL 1658

Query: 427  EEKLRASQMAEE---ITRKELQSVRLKLQQQIVTIENAEKEKN----ENSDLKQQISSLQ 479
            ++ LR  +  +E   I  +    ++ ++++   T+E  E+ +     E  D  +++  L 
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718

Query: 480  IQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEK 539
             Q TSL  ++  L      L+  VE   ++ RN   +A+KA  +A    EE     L+++
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE-----LKKE 1773

Query: 540  HKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETEN 599
                  +   ++   Q  + LQ       +     +  LK  +++++ LE +  ELE E 
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQH------RLDEAEQLALKGGKKQIQKLETRIRELEFEL 1827

Query: 600  QVLNRQNV-PFEDYTRLQKRLKDIQRRHNEFRSLIL-VPNMPPTASINPVSFQSSAMVPS 657
            +   ++N    +   + ++R+K++  +  E R  +L + ++     +   S++  A    
Sbjct: 1828 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQA---- 1883

Query: 658  MELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
                      +EQ    L+  RK   ELE  + +
Sbjct: 1884 -------EEADEQANAHLTKFRKAQHELEEAEER 1910



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 137/616 (22%), Positives = 278/616 (45%), Gaps = 97/616 (15%)

Query: 30   EFQKMLID-ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ--TQQEKLQL 86
            EFQKM+   E + C  +      +  +H        K++  LK    EK+  T +E+ Q 
Sbjct: 801  EFQKMVQRRESIFCIQYNIR-SFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQK 859

Query: 87   LLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
              +EL  +   K K+LEE KL  L  +K +L   Q+Q + E+   E   + +E  ++   
Sbjct: 860  TKDEL-AKSEAKRKELEE-KLVTLVQEKNDL---QLQVQAES---ENLLDAEERCDQ--- 908

Query: 147  VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKD 206
                       +K++F+           E KIK   E+    ED+EE+     N +LT  
Sbjct: 909  ----------LIKAKFQL----------EAKIK---EVTERAEDEEEI-----NAELTAK 940

Query: 207  SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSL 266
             +++E    E   L + +  LE  +A+++ EK  +E +V+N       +L+ +  T+  L
Sbjct: 941  KRKLEDECSE---LKKDIDDLELTLAKVEKEKHATENKVKNL----TEELSGLDETIAKL 993

Query: 267  EAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELK--------HS 318
              EK++     ++   +LQ+  ++   L     K E+++  L S +++ K        + 
Sbjct: 994  TREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK 1053

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
             KLE  D+KL    +  +LE ++ ++   L     +   L++ VE  + L ++  ++ I+
Sbjct: 1054 RKLE-GDLKL-AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK-IK 1110

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD----LEKM-------------KVEHDVWRQS 421
            ++QA  EE  +++   +  + + E + +D    LE++             ++E +  R++
Sbjct: 1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREA 1170

Query: 422  E-----KDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA-EKEKNENSDLKQQI 475
            E     +D  E  L+   M   + +K   SV  +L +QI  ++   +K + E S+ K +I
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLEI 1229

Query: 476  SSLQIQVTSLAQSENDLLNSNQMLKEMV-------ERLKQECRNFRSQAEKAQLEAEKTL 528
              L   + S+++S+ +L    + L++ +       E +++      +Q  + Q EA +  
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289

Query: 529  EEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL 588
             +     LEEK  +  +++  ++ + Q  E+L+R    + K K+   + L+  +   ++L
Sbjct: 1290 RQ-----LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344

Query: 589  EAKKEELETENQVLNR 604
              + EE +     L R
Sbjct: 1345 REQYEEEQEGKAELQR 1360



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 130/553 (23%), Positives = 248/553 (44%), Gaps = 84/553 (15%)

Query: 22   SGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQT-- 79
            + L   Q  F K+L + + +CE  +A  +    E   L  E  KL+N  +   ++ +T  
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500

Query: 80   -QQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLD 138
             + + L+  + +L  ++ E  K + E++    + +++EL +A IQ  LE          +
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELE---KSRKQIELEKADIQLALE--------EAE 1549

Query: 139  EEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEEL-RNQ 197
              +E   A   +++ E T +KSE +                   +IA  +E+ E+L RN 
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDR------------------KIAEKDEEIEQLKRNY 1591

Query: 198  LLNVDLTKDSKRVEQLAR-EKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQL 256
               V+  + +   E  +R E + L +K++G   E+          E Q+ +A     RQ 
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI----------EIQLSHAN----RQA 1637

Query: 257  AEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELK 316
            AE    +RS++ + +   L  +   +  +   EQ       L   ER  N L ++V+EL+
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ-------LAIVERRANLLQAEVEELR 1690

Query: 317  HSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEIL---KAAVEHHKVLLVEKD 373
             + +        +T RA+   E+E       +  L + N  L   K  +E   + L  + 
Sbjct: 1691 ATLE--------QTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742

Query: 374  RELIRKVQAAKEEGYQKL---VVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKL 430
             +  R  + A+E+  + +    ++ +E  + ++  A LE+MK   +   Q+ KD      
Sbjct: 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE---QTVKDLQHRLD 1799

Query: 431  RASQMAEEITRKELQSVRLKLQQQIVTIE-NAEKEKNENSDLKQQISSLQIQVTSLA-QS 488
             A Q+A +  +K++Q    KL+ +I  +E   E E+ +N++  + +   + +V  L  QS
Sbjct: 1800 EAEQLALKGGKKQIQ----KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQS 1855

Query: 489  ENDLLNSNQMLKEMVERLKQECRNFRSQAEKA--QLEAEKTLEEKQIQWLEEKHKLHERI 546
            E D  N  + L+++V++L+ + ++++ QAE+A  Q  A  T   K    LEE     ER 
Sbjct: 1856 EEDRKNVLR-LQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEE---AEERA 1911

Query: 547  TDREEKYNQAKEK 559
               E + N+ + K
Sbjct: 1912 DIAESQVNKLRAK 1924



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 131/618 (21%), Positives = 261/618 (42%), Gaps = 75/618 (12%)

Query: 47   ANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRG------ELVEKTK 100
            A  + L+ E + L+ +   L+  L  +  EK   + K++ L EEL G      +L  + K
Sbjct: 939  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKK 998

Query: 101  DLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKS 160
             L+E   Q L   + E  +     + ++ + ++  +L+  +E+ +            L+ 
Sbjct: 999  ALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKK-----------LRV 1047

Query: 161  EFEHQKEEYARILDEGKIKYESE-IARLEEDKEELRNQLLNVDL--TKDSKRVEQLAREK 217
            + E  K +      EG +K   E I  LE DK++L  +L   D    +   +VE      
Sbjct: 1048 DLERNKRKL-----EGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102

Query: 218  VYLCQKLKGLEAEVAELKAEKE---NSEAQVENAQRIQVRQLAEMQATVR---SLEAEKQ 271
            +   +K+K L+A + EL+ E E    + A+ E  +    R+L E+   +     + + + 
Sbjct: 1103 LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQI 1162

Query: 272  SANLRAE----RLEKELQSSSEQNTFLINKLHKAERE-INTLSSKVKELKHSNKLEITDI 326
              N + E    +L ++L+ ++ Q+  ++  L K   + +  L  ++  L+          
Sbjct: 1163 ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ---------- 1212

Query: 327  KLETARAKSELERERNKIQSELDGLQSDNE-ILKAAVEHHKVLLVEKD-----RELIRKV 380
                 R K +LE+E+++ + E+D L S  E + K+     K+    +D     R    ++
Sbjct: 1213 -----RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267

Query: 381  QAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEIT 440
            Q +  E   +   LQ E  EL  +L + E +  +    +Q+   Q EE  R  Q+ EE  
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKR--QLEEENK 1325

Query: 441  RKELQSVRLKLQQQIVTI--ENAEKEKNENSDLKQQISSLQIQVTS-LAQSENDLLNSNQ 497
             K   +  L+  +    +  E  E+E+   ++L++ +S    +V     + E D +   +
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1385

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAK 557
             L+E  ++L Q  ++   Q E    +     + KQ      + ++ + + D E   + A 
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ----RLQGEVEDLMVDVERANSLA- 1440

Query: 558  EKLQRAAIAQKKR---KSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTR 614
                 AA+ +K+R   K L E K K  + + E+  + KE      ++   +N   E   +
Sbjct: 1441 -----AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495

Query: 615  LQKRLKDIQRRHNEFRSL 632
            L+   ++ +    E   L
Sbjct: 1496 LETVKRENKNLEQEIADL 1513



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 78/331 (23%), Positives = 153/331 (46%), Gaps = 32/331 (9%)

Query: 371  EKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRL-ADLEKMKVEHDVWRQSEKDQYEEK 429
            +K ++ + K +A ++E  +KLV L  EK +L+ ++ A+ E +    +   Q  K +++ +
Sbjct: 858  QKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLE 917

Query: 430  LRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQ-- 487
             +  ++ E    +E  +  L  +++        K ++E S+LK+ I  L++ +  + +  
Sbjct: 918  AKIKEVTERAEDEEEINAELTAKKR--------KLEDECSELKKDIDDLELTLAKVEKEK 969

Query: 488  --SENDLLNSNQMLKEMVERLKQECRNFRS--QAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
              +EN + N  + L  + E + +  R  ++  +A +  L+  +  E+K     + K KL 
Sbjct: 970  HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE 1029

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLN 603
            +++ D E    Q  EK  R  + + KRK   E  LK  QE +  LE  K++L+     L 
Sbjct: 1030 QQVEDLESSLEQ--EKKLRVDLERNKRKL--EGDLKLAQESILDLENDKQQLDER---LK 1082

Query: 604  RQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
            +++    +Y +LQ +++D Q    +F+  I        A I  +  +  A   +      
Sbjct: 1083 KKDF---EYCQLQSKVEDEQTLGLQFQKKI----KELQARIEELEEEIEAERATRA---K 1132

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQLE 694
               Q   + REL  L +RLEE       Q+E
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIE 1163



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 44/211 (20%), Positives = 97/211 (45%), Gaps = 10/211 (4%)

Query: 406  ADLEK-MKVEHDVWRQSEKDQYEEKLRASQMAEEITR--KELQSVRLKLQQQIVTIENAE 462
            A+ EK M    + +++++ +  + + +  ++ E++    +E   ++L++Q +   + +AE
Sbjct: 844  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 463  KEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQL 522
            +  ++    K Q+ +   +VT  A+ E ++   N  L     +L+ EC   +   +  +L
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEEEI---NAELTAKKRKLEDECSELKKDIDDLEL 960

Query: 523  EAEKTLEEKQIQWLEEKHKLHERITDREE---KYNQAKEKLQRAAIAQKKRKSLHENKLK 579
               K  +EK     + K+ L E ++  +E   K  + K+ LQ A           E+K+ 
Sbjct: 961  TLAKVEKEKHATENKVKN-LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019

Query: 580  RLQEKVEVLEAKKEELETENQVLNRQNVPFE 610
             L +    LE + E+LE+  +   +  V  E
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  110 bits (274), Expect = 6e-24
 Identities = 150/689 (21%), Positives = 301/689 (43%), Gaps = 81/689 (11%)

Query: 37   DERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELV 96
            ++RL+ E  +   Q LK E  R Q    +L+ E +    ++  ++E  +L  EE R + +
Sbjct: 564  EQRLKREQEERRDQLLKREEERRQQ---RLKREQEERLEQRLKREEVERLEQEERREQRL 620

Query: 97   EKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHT 156
            ++ +  EE + Q+L  ++ E  R   QQ+L    +ER     +  E+   +  +L+ EH 
Sbjct: 621  KREEPEEERRQQLLKSEEQEERR---QQQLRREQQERREQRLKREEEEERLEQRLKREHE 677

Query: 157  FLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLARE 216
              + E E  +EE  +  +  K +      +LE + +  ++++ +    ++ +R  Q   E
Sbjct: 678  EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 217  KVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLR 276
            K       +  E+E+   + E+ + + Q E  +R    Q    + + R  +       LR
Sbjct: 738  K------RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791

Query: 277  AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSE 336
             +R E++L++   Q           +RE   L  + ++ +   +    + +L+    + +
Sbjct: 792  EQR-ERQLRAEERQ-----------QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839

Query: 337  LERERN--KIQSELDGLQSDNEILKAAVEHHKVLL---VEKDRELIRKVQAAK----EEG 387
            L+R     ++Q E DGLQ D E  ++  +         +E++R+  R    AK    E+ 
Sbjct: 840  LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899

Query: 388  YQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSV 447
             ++  +LQ+E+ EL+    + EK +      RQ ++ QY E+ +  Q  E++ R+E +  
Sbjct: 900  RKEQQLLQEEEEELQRE--EREKRR------RQEQERQYREEEQLQQEEEQLLREEREKR 951

Query: 448  RL-----------KLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSN 496
            R            KLQQ+   +   E EK    + +++    +     L Q E  LL   
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE----ELQQEEEQLLREE 1007

Query: 497  QMLKEMVERLKQECRNFRSQAEKAQLEAE----KTLEEKQIQWLEEKH-KLHERITDREE 551
            +  +   E  +Q  +    Q E+ QL  E    + L+E++ Q+ EE+  +  E     EE
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067

Query: 552  KYNQAKEKLQRA-----AIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQN 606
            +  + +++L+R       + Q++ + L E   KR +++ E    ++EEL+ E + L R+ 
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127

Query: 607  VPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHM 666
                   R ++R ++++R++ E   +              +  +        EL      
Sbjct: 1128 -------REKRRRQELERQYREEEEV--------QQEEEQLLREEPEKRRRQELERQYRE 1172

Query: 667  QEEQHQRELSLLRKRLEELETTQRKQLEE 695
            +EE  Q E  LLR+  E+    + +Q  E
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYRE 1201



 Score =  108 bits (271), Expect = 1e-23
 Identities = 157/721 (21%), Positives = 301/721 (41%), Gaps = 115/721 (15%)

Query: 43   EHHKANYQTLKAEHTRLQNEHVKLQNELKHLFN-EKQTQQEKLQLLLEELRGELVEKTKD 101
            E H+  ++  + E  RL+ E  + ++ LK     E+  Q+ + Q L  +   E  E+   
Sbjct: 432  ERHEQKHEQERREQ-RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 102  LEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSE 161
            LEE + +    ++ E    Q+++E E    +R +  +EE      +  +LR E   L+ E
Sbjct: 491  LEEEERR----EQQERREQQLRREQEERREQRLKRQEEE----ERLQQRLRSEQQ-LRRE 541

Query: 162  FEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLARE-KVYL 220
             E ++E+  +  +E +++ E    RL+ ++EE R+QLL     ++ +R ++L RE +  L
Sbjct: 542  QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK---REEERRQQRLKREQEERL 598

Query: 221  CQKLKGLEAEVAELKAEKENSEAQVE-NAQRIQVRQLAEMQATVRSLEAEKQSANLRAER 279
             Q+LK  E E  E +  +E    + E   +R Q    +E Q   R  +  ++    R +R
Sbjct: 599  EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658

Query: 280  LEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL---------------------KHS 318
            L++E     E+    + + H+ ER    L+ + +E                         
Sbjct: 659  LKRE--EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
            +K+     K E  R + E E +R + +SEL   + +         H +    E+ R+   
Sbjct: 717  SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER-------AHRQQQEEEQRRDFTW 769

Query: 379  KVQAAK--EEGYQKL------------VVLQDEKLELENRLADLEKMKVEHDVWRQ---- 420
            + QA +  E G Q+L             +  +E+ + E R    E+ K +    R+    
Sbjct: 770  QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 421  -----SEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQ--------------------- 454
                  E++Q + + RA Q+ EE    +    R + Q+Q                     
Sbjct: 830  ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889

Query: 455  ---IVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECR 511
                   E   KE+    + ++++   + +     + E       Q+ +E  + L++E  
Sbjct: 890  YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949

Query: 512  NFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRK 571
              R Q  + Q   +K L++K+ Q L E+ +   R  +RE+KY + +E      + Q++ +
Sbjct: 950  KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR-QEREKKYREEEE------LQQEEEQ 1002

Query: 572  SLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRS 631
             L E + KR +++ E    KK+EL+ E + L R+        R ++RL++ +R++ E   
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREE-------REKRRLQERERQYREEEE 1055

Query: 632  LILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRK 691
            L              +  +        EL      +EE  Q E  LLR+  E+    +R+
Sbjct: 1056 L--------QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107

Query: 692  Q 692
            +
Sbjct: 1108 R 1108



 Score =  107 bits (267), Expect = 4e-23
 Identities = 153/640 (23%), Positives = 287/640 (44%), Gaps = 58/640 (9%)

Query: 31   FQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHV---KLQNELKHLFNEKQTQQEKLQLL 87
            + K  + E+LR E      Q L+ E   LQ E     + Q + +    E+Q QQE+ QLL
Sbjct: 890  YAKPALQEQLRKEQ-----QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 88   LEEL-------RGELVEKTKDLEEMKLQIL--TPQKLELL-RAQIQQELETPMRERFRNL 137
             EE        R     K K L++ + Q+L   P+K     R +  +E E   +E  + L
Sbjct: 945  REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004

Query: 138  DEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELR-- 195
             EE EK R    +  +E  + K + E Q+EE   + +E + +   E  R   ++EEL+  
Sbjct: 1005 REEREKRR----RQEWERQYRKKD-ELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059

Query: 196  -NQLLNVDL-TKDSKRVEQLAREKVYLCQKLKGLEAEVAE--LKAEKENSEAQVENAQRI 251
              QLL  +  T+  + +E+  R++  L Q+ + L  E  E   + E+E    + E  Q+ 
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSK 311
            + + L E +   R  E E+Q       + E+E     E       +L +  RE   L  +
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179

Query: 312  VKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD-----NEILKAAVEHHK 366
             ++L    + +    +    R + EL+R++ K +   +  +SD         + AV  +K
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239

Query: 367  VLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQY 426
            V    ++ E  R+++ ++    Q    LQ    E + R  + E+ +     W+Q ++   
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR-----WQQRDRHFP 1294

Query: 427  EEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLK----------QQIS 476
            EE+    +  +E  R++ +S   + ++Q++  E  EK + + +D K          ++  
Sbjct: 1295 EEEQLEREEQKEAKRRDRKS---QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351

Query: 477  SLQIQVTSLAQSENDLLNSNQMLK--EMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQ 534
             L+ Q       E +L +  Q  K  E  +RL+++ R  +   E+ QL  ++  E++  Q
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER-EQQLRQ 1410

Query: 535  WLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEE 594
              + K +  E+   R+E+  + +E+ Q+    +++RK L E +  R +   +  E ++  
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470

Query: 595  LETENQVLNRQNVP---FEDYTRLQKRLKDIQRRHNEFRS 631
             E E Q L+RQ       E+  +L+++ +D + R  E RS
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510



 Score =  103 bits (257), Expect = 5e-22
 Identities = 145/693 (20%), Positives = 303/693 (43%), Gaps = 76/693 (10%)

Query: 37   DERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLL----EELR 92
            ++RL+ +  +   Q       +L+ E  + + +L     EK+ +QE+ +  L    EE R
Sbjct: 516  EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575

Query: 93   GELVEKTKDLEEMKLQILTPQKLE--LLRAQIQQ-----------ELETPMRERFRNLDE 139
             +L+++ ++  + +L+    ++LE  L R ++++           + E P  ER + L +
Sbjct: 576  DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635

Query: 140  EVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR----LEEDKEELR 195
              E+      +LR E    + +   ++EE  R+  E ++K E E  R    L E+++E  
Sbjct: 636  SEEQEERRQQQLRREQQERREQRLKREEEEERL--EQRLKREHEEERREQELAEEEQEQA 693

Query: 196  NQLLNVDLTKDSKRVEQLA---REKVY-LCQKLKG-LEAEVAELKAEKENSEAQVENAQR 250
             + +   + K   ++E  A   + KVY   +K +G    +  E K  +  SE Q +  +R
Sbjct: 694  RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 251  IQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSS 310
               +Q  E Q    + + + +  + R  +         EQ    +    + +RE   L  
Sbjct: 754  AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERER--NKIQSELDGLQSDNEILKAAVEHHKV- 367
            + ++ +   +    + +L+    + +L+R     ++Q E DGLQ D E  ++  +     
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 368  --LLVEKDRELIRKVQAAK----EEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQS 421
                +E++R+  R    AK    E+  ++  +LQ+E+ EL+    + EK +      RQ 
Sbjct: 874  WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE--EREKRR------RQE 925

Query: 422  EKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQ 481
            ++ QY E+ +  Q  E++ R+E +  R + +++    +   ++K E      Q+   + +
Sbjct: 926  QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE------QLLGEEPE 979

Query: 482  VTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHK 541
                 + E       ++ +E  + L++E    R Q  + Q   +  L++++ Q L E+ +
Sbjct: 980  KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039

Query: 542  LHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQV 601
               R+ +RE +Y + +E      + Q++ + L E +  R ++++E    K+EEL+ E + 
Sbjct: 1040 -KRRLQERERQYREEEE------LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092

Query: 602  LNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELP 661
            L R+          +++ ++ +    E   L+                +        EL 
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLR---------------EEREKRRRQELE 1137

Query: 662  FPPHMQEEQHQRELSLLRKRLEELETTQRKQLE 694
                 +EE  Q E  LLR   EE E  +R++LE
Sbjct: 1138 RQYREEEEVQQEEEQLLR---EEPEKRRRQELE 1167



 Score =  100 bits (248), Expect = 6e-21
 Identities = 135/663 (20%), Positives = 288/663 (43%), Gaps = 78/663 (11%)

Query: 28  QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
           + + Q++  +++LR +  +   +  + E  R Q E  + Q E +    E+Q ++E+ +  
Sbjct: 294 EQQQQRLRREQQLRRKQEEERRE--QQEERREQQERREQQEERR----EQQLRREQEERR 347

Query: 88  LEELRGELVEKTKDL--------EEMKLQILTPQKL----------------------EL 117
            ++LR E  E+ ++         E  + Q+   Q+L                      +L
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 118 LRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGK 177
            R Q  +  +   RE+    ++E E++   + + R E   LK E E +++   R  +  +
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR-LKREQEERRDWLKREEETER 466

Query: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAE 237
            + E    +L+ D+EE R +   + L ++ +R +Q  RE     Q+L+  + E  E + +
Sbjct: 467 HEQERRKQQLKRDQEEERRERW-LKLEEEERREQQERRE-----QQLRREQEERREQRLK 520

Query: 238 KENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINK 297
           ++  E +++   R + +   E +     L   ++   L  ER E+ L+   E+    + K
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 298 LHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEI 357
             +  R+      + + L+   K E  +   +  R +  L+RE  + +     L+S+ + 
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ- 639

Query: 358 LKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADL--------- 408
                E  +   + ++++  R+ +  +EE  ++L      + E E R  +L         
Sbjct: 640 -----EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694

Query: 409 EKMKVEHDVWR---QSEKDQYEEKL--RASQMAEEITRKELQSVRLKLQQQIVTIENAEK 463
           E++K     W+   +SE D  + K+  R  +   +  R+E +  R + + ++   E    
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754

Query: 464 EKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER-LKQECRNFRSQ------ 516
            + +  + +++  + Q Q    ++     L++   L+E  ER L+ E R  R Q      
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814

Query: 517 AEKAQLEAEKTLEEKQIQWLEEKHKLHER-----ITDREE--KYNQAKEKLQRAAIAQKK 569
            EK Q   ++   EK++Q+LEE+ +L  R     + + E+  + +Q + + Q     QK 
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874

Query: 570 RKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEF 629
           R  L E + KR +  +    A +E+L  E Q+L  +    +   R ++R ++ +R++ E 
Sbjct: 875 RWQLEEER-KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE 933

Query: 630 RSL 632
             L
Sbjct: 934 EQL 936



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 140/641 (21%), Positives = 281/641 (43%), Gaps = 75/641 (11%)

Query: 73  LFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRE 132
           L  EK+ + +  + LL++ R E  ++  +  + +L+    Q+    R Q +QE E  + E
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR----RRQKRQEQERELAE 150

Query: 133 RFRNLDEEVEKYRAVY--NKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEED 190
                +E+ EK   +   ++ R +    +   E Q+ E  R  +E     +        D
Sbjct: 151 G----EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206

Query: 191 KEELRNQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAEVAELKAEKENSEAQVENAQ 249
           +E+LR + L     K  +  +Q  RE+   + Q+ +  E    E    KE  + Q E  Q
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 250 RIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLS 309
           R   R+L E +  +R LE ++    LR ER E+E Q    +    + +  + ER      
Sbjct: 267 R--QRELQEEEEQLRKLERQE----LRRERQEEEQQQQRLRREQQLRRKQEEERR----E 316

Query: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLL 369
            + +  +   + E  + + E    + + ER   +++ E +  + + ++ +   E  +   
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376

Query: 370 VEKDRELIRKVQAAKEEGYQKLVVLQ-DEKLELENRLADLEKMKVEHDVWRQSEKDQYEE 428
           + ++++L R+ Q  +E+  ++   L+ +++L  E +L   ++++ E  + R+ E++++E+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436

Query: 429 KLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQS 488
           K    +  E+  ++E +  R  L+++       E E++E    KQQ+   Q +     + 
Sbjct: 437 K-HEQERREQRLKREQEERRDWLKRE------EETERHEQERRKQQLKRDQEE----ERR 485

Query: 489 ENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITD 548
           E  L    +  +E  ER +Q+ R  R Q E+          E++++  EE+ +L +R+  
Sbjct: 486 ERWLKLEEEERREQQERREQQLR--REQEER---------REQRLKRQEEEERLQQRLRS 534

Query: 549 REEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLE-----AKKEELETENQVLN 603
            ++   + +E+               E  LKR +EK    E      K+E+ E  +Q+L 
Sbjct: 535 EQQLRREQEER--------------REQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 604 R------QNVPFEDYTRLQKRLK--DIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMV 655
           R      Q +  E   RL++RLK  +++R   E R    +    P         +S    
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 656 PSMELPFPPHMQEEQHQRELSLLRKRLEE-LETTQRKQLEE 695
              +       +E+Q +RE  L R+  EE LE   +++ EE
Sbjct: 641 ERRQQQL---RREQQERREQRLKREEEEERLEQRLKREHEE 678



 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 138/632 (21%), Positives = 276/632 (43%), Gaps = 72/632 (11%)

Query: 28   QSEFQKMLIDERLRCEHHKAN----YQTLKAEHTRLQNEHVK-LQNELKHLFNEKQTQQE 82
            + E Q+    +R R E  +++    ++  K    R    + K  +NE      + Q +  
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261

Query: 83   KLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVE 142
            + Q  L+ L GE  E+ ++ E  + Q       E    Q+++E +   + R R   EE +
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE--EEQLEREEQKEAKRRDRKSQEEKQ 1319

Query: 143  KYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDK----EELRNQL 198
              R    + R      + E + +  E  ++L E   + E  + R E D+    EELR+Q 
Sbjct: 1320 LLREEREEKRR-----RQETDRKFREEEQLLQE---REEQPLRRQERDRKFREEELRHQE 1371

Query: 199  LNVDLTKDSKRVEQLAREKVYLC--QKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQL 256
                  ++ +R+ +  RE+ +L   Q+L+  E E  +L+ +++    + E       +QL
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE-QQLRQDRDRKFREEE-------QQL 1423

Query: 257  AEMQATVRSLEAEKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLSSKVKE 314
            +  +   +  E E+Q      ER  LE+E Q   E+        H+  RE   L  + +E
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER--------HRKFREEEQLLQE-RE 1474

Query: 315  LKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDR 374
             +  ++ E     LE  +     ER+R   + EL   + + + L+   + H+    ++ R
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ---QRQR 1531

Query: 375  ELIRKVQAAK--EEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQY---EEK 429
            + +++ Q  +  E G Q+    +D K   E +L    + + E  + RQ    ++   E+K
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQD-RDRKFREEEQL---RQEREEQQLSRQERDRKFRLEEQK 1587

Query: 430  LRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSE 489
            +R  +   +    E Q  R + QQQ+   +  +++  E+  L Q+    Q+      + +
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLR--QERDRKFREDEQLLQEREEQQLH---RQERD 1642

Query: 490  NDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHE----- 544
               L     L+   +  +Q+ R+ R +  + + +  +  EE+Q++  E   K  E     
Sbjct: 1643 RKFLEEEPQLRR--QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700

Query: 545  RITDREEKYNQAKEKLQRAAIAQK------KRKSLHENKLKRLQEKVEVLEAKKEELETE 598
            R  +RE K+ Q +++L+R  + +K       R+   + +L+R +   ++LE ++   E E
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760

Query: 599  NQVLNRQ--NVPFEDYTRLQKRLKDIQRRHNE 628
             Q L RQ  +  F +  +L++  ++ Q R  E
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 110/577 (19%), Positives = 253/577 (43%), Gaps = 46/577 (7%)

Query: 32   QKMLIDER----LRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            ++ L+ ER    LR +     ++  +  H     + ++ +  L+    E++  +E+ QL 
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400

Query: 88   LEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAV 147
             +E   +L +        + Q L+ Q+ +    + +Q++    RER + L+EE +  +  
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER-KFLEEEQQLRQER 1459

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDK----EELRNQLLNVDL 203
            + K R E   L+   E Q     R  D   ++ E ++ R E D+    +ELR+Q      
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQER--DRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517

Query: 204  TKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAE------KENSEAQVENAQRIQVRQLA 257
             ++ +++ +  R++ +L ++ +    E  + + +      +E  + + E  ++   RQ  
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577

Query: 258  EMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKH 317
            + +  +   +  +Q    +    E++L+    Q      +  K   +   L  + ++  H
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637

Query: 318  SNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELI 377
              + +   ++ E    + E E++   ++ + D    + E L    E  ++   E+DR+  
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQ---LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694

Query: 378  RKVQAAKEEGYQKLVVLQDEKL---ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
             + Q  + +  ++  + ++++L   ELE +  + E+++ E +  +   +++Y + L   Q
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSEND--L 492
            +  E   +E Q +R + + +    E   +++ E   L+ Q S  + +     + E +   
Sbjct: 1755 LRPE---REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811

Query: 493  LNSNQ------------MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKH 540
            L   Q             L+E  +RL+QE R+ + +AE+     EK+  E+Q  W EE+ 
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQE-RDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870

Query: 541  KLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENK 577
            K   R  +RE K  +  E ++R    +++ + + E K
Sbjct: 1871 K---RRQERERKLRE--EHIRRQQKEEQRHRQVGEIK 1902



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 135/662 (20%), Positives = 280/662 (42%), Gaps = 56/662 (8%)

Query: 30   EFQKMLIDERLRCEHHKANYQTLKAEHTRLQN--EHVKLQNELKHLFNEKQT--QQEKLQ 85
            E +++L +ER      +   +  + E   LQ   E    + E    F E++   Q++  +
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375

Query: 86   LLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQI-----QQELETPMRERFRNLDEE 140
             L EE R    E+ +   + + Q+   ++ + LR        ++E +   +ER R   EE
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKI---KYESEIARLEEDKEELRNQ 197
             ++ R    +   E  FL+ E + ++E + +  +E ++   + E ++ R E D++ L  +
Sbjct: 1436 EQQVR----RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491

Query: 198  LLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLA 257
                   +D K  EQ  R +     + K LE E    + +++    Q E   R Q R   
Sbjct: 1492 QQLRRQERDRKFREQELRSQE---PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548

Query: 258  EMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLIN--KLHKAEREINTLSSKVKEL 315
              Q   R    E+Q   LR ER E++L        F +   K+ + E+E   +  + +  
Sbjct: 1549 RRQDRDRKFREEEQ---LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQ---SELDGLQSDNEILKAAVEHHKVLLVEK 372
            +   + ++   +    R   +L +ER + Q    E D    + E      E  + L  ++
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 373  DRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRA 432
            DR+  R+ +   +EG ++ +  Q+   +       L + + E   + Q E+    ++L  
Sbjct: 1666 DRKF-REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK-FLQEEQQLRRQELER 1723

Query: 433  SQMAEEITRKELQSVRLKLQQQIVTIENAE--KEKNENSDLKQQISSLQIQVTSLAQSEN 490
                EE  R+E +  +L+ Q++   I   E  + + E   L++Q    + +     + E 
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783

Query: 491  DLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDRE 550
            +     Q+  +  +R  +E    R + E+ QL  ++   + + +W EE+ +L E    +E
Sbjct: 1784 E---EQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEE----QE 1834

Query: 551  EKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFE 610
            ++  Q +++  RA     + +   + K +R ++++   E +K   E E ++        E
Sbjct: 1835 QRLRQERDRQYRA-----EEQFATQEKSRREEQELWQEEEQKRRQERERKLR-------E 1882

Query: 611  DYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQ 670
            ++ R Q++    ++RH +   +           + P + Q  A VP    P   ++QE++
Sbjct: 1883 EHIRRQQK---EEQRHRQVGEIKSQEGKGHGRLLEPGTHQ-FASVPVRSSPLYEYIQEQR 1938

Query: 671  HQ 672
             Q
Sbjct: 1939 SQ 1940


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  108 bits (271), Expect = 1e-23
 Identities = 106/503 (21%), Positives = 230/503 (45%), Gaps = 35/503 (6%)

Query: 164 HQKEEYARILDEGKIKYESEIARLEEDKEELRNQ--LLNVDLTKDSKRVEQLAREKVYLC 221
           H   ++A  L++      ++  + +   EEL  +   L+++L +++   E+L  +   L 
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227

Query: 222 QKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLE 281
           +KL+ +E+E +E++   +  + ++E A+ +  +Q  + +A     E +  SA L+A+  E
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287

Query: 282 KELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKL--ETARAKSELER 339
            EL +   Q      K+ + E +I     K++E +   + +   I+   E  R + E+  
Sbjct: 288 NELWNRLNQQQE--EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345

Query: 340 ERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL 399
           E+ +     + +  + E     +E       EK REL  K+   ++   Q+    ++EK+
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405

Query: 400 -ELENRLADLEKM---------------KVEHDVWRQSEKDQYEEKLRASQMAEEITRKE 443
            E E R     KM               + E  +WRQ EK   +EK+R  +  +E     
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 465

Query: 444 LQSVRLKLQQQI----VTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQML 499
            Q  +++ Q++I      +   EK + +   + +Q   +  Q   + + E  +    + +
Sbjct: 466 RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI 525

Query: 500 KEMVERLKQECRNFRSQAEKAQLEAEKTLE-EKQIQWLEEKHKLHERITDREEKYNQAKE 558
           +E  E+++++    R Q E  Q + EK  E E+++Q  E+  +  E+I ++EEK  + KE
Sbjct: 526 REQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKE 585

Query: 559 KL--QRAAIAQKKRK------SLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFE 610
           K+  Q   I +++ K       + E + K  +++ ++ E +++  E E ++  ++   +E
Sbjct: 586 KIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645

Query: 611 DYTRLQKRLKDIQRRHNEFRSLI 633
              RL+++ + +Q       + I
Sbjct: 646 QEVRLRQQEEKMQEHQEHLEAAI 668



 Score =  106 bits (265), Expect = 6e-23
 Identities = 126/555 (22%), Positives = 252/555 (45%), Gaps = 84/555 (15%)

Query: 65  KLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQI----LTPQKLELLRA 120
           K   EL+   +   TQ++K    +EEL       TK+ + + L++    +T ++L+   A
Sbjct: 172 KFAGELEQALSAVATQKKKADRYIEEL-------TKERDALSLELYRNTITDEELKEKNA 224

Query: 121 QIQQELETPMRERFR-NLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIK 179
           ++Q++L+    E+    L+ +  K +    KL      L++E +H  +E           
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---------- 274

Query: 180 YESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQ-KLKGLEAEVAELKA-- 236
            +S  A+L+   EE  N+L N        R+ Q   EK++  + K++  E ++ E +   
Sbjct: 275 -QSVSAKLQAQVEE--NELWN--------RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI 323

Query: 237 -EKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLI 295
            E+E    + E   R Q   + E +  +R  E        +  RLE+ +    E+   L 
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383

Query: 296 NKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDN 355
            K+H+ E        K++E              E  R + E  RE+ K Q +   +    
Sbjct: 384 EKMHEQE--------KIREQ-------------EEKRQEEEKIREQEKRQEQEAKMWRQE 422

Query: 356 EILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVE 414
           E ++   E        K RE  +K+   +E+ +++  + ++EK  E E      EK++ +
Sbjct: 423 EKIREQEE--------KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474

Query: 415 HDVWRQSEKDQYEEKLRASQMAEEITRKE--LQSVRLKLQQQIVTI-ENAEKEKNENSDL 471
            ++WRQ EK   +EK+R  +  E++ R+E  +     K+++Q   +    EK + +   +
Sbjct: 475 EEIWRQKEKMHEQEKIRKQE--EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532

Query: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
           ++Q   ++ Q   + + E  +    + ++E  E+++++    R Q EK + + EK  E++
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQ-EKMRRQEEKIREQEEKIREQKEKIREQE 591

Query: 532 QIQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKV--- 585
           +  W +E     E+I ++EE   + +EK+   +     Q+++    E K++R +EK+   
Sbjct: 592 EKIWEQE-----EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646

Query: 586 EVLEAKKEELETENQ 600
           EV   ++EE   E+Q
Sbjct: 647 EVRLRQQEEKMQEHQ 661



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 103/424 (24%), Positives = 198/424 (46%), Gaps = 40/424 (9%)

Query: 53  KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTP 112
           K E  +L     +LQ E  HL  E Q+   KLQ  +EE   EL  +    +E K+     
Sbjct: 250 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE--NELWNRLNQQQEEKMW-RQE 306

Query: 113 QKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKL--RYEHTFLKSEFEHQKEEYA 170
           +K++    +IQ++ E  +RE+   + E+ EK R     +  + E    + E   +KEE  
Sbjct: 307 EKIQEWEEKIQEQ-EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365

Query: 171 RILDEGKIKYESEIARLEE---DKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGL 227
           R L+E   + E +I  LEE   ++E++R Q        + KR E+   EK+   +K +  
Sbjct: 366 RRLEEMMWEKEEKIRELEEKMHEQEKIREQ--------EEKRQEE---EKIREQEKRQEQ 414

Query: 228 EAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSS 287
           EA++   + +    E ++   ++   RQ  ++    +  E EK+       R E++++  
Sbjct: 415 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR-E 473

Query: 288 SEQNTFLINKLHKAEREINTLSSKV---KELKHSNKLEITDIKLETARAKSELERERNKI 344
            E+      K+H+ E+ I     KV   +E  H  + +I + + +  R + ++  +  KI
Sbjct: 474 QEEIWRQKEKMHEQEK-IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532

Query: 345 QSELDGLQSDNEIL-----KAAVEHHKVLLVEKDR---ELIRKVQAAKEEGYQKLVVLQD 396
           + + + ++   E++     K   +  K+   EK R   E IR+ +    E  +K+   ++
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592

Query: 397 EKLELENRLADLEKMKVEHD--VWRQSEKDQYEEKLRASQMAEEITRKE----LQSVRLK 450
           +  E E ++ + E+M  E +  +W Q EK   E++ +  +  E++ R+E     Q VRL+
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 651

Query: 451 LQQQ 454
            Q++
Sbjct: 652 QQEE 655



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 82/387 (21%), Positives = 169/387 (43%), Gaps = 52/387 (13%)

Query: 55  EHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQK 114
           E  R Q E ++ Q E      E   ++E+     EE+  E  EK + LEEM       +K
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW-----EK 375

Query: 115 LELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILD 174
            E +R     ELE  M E+   + E+ EK        R E   ++ + + Q++E      
Sbjct: 376 EEKIR-----ELEEKMHEQ-EKIREQEEK--------RQEEEKIREQEKRQEQEAKMWRQ 421

Query: 175 EGKIKYESEIARLEEDKEELRNQLLNVD--LTKDSKRVEQLAREKVYLCQKLKGLEAEVA 232
           E KI+ + E  R +E K   + + ++    + ++ KR EQ   E+++  Q+ K  E E  
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ---EEMWR-QEEKIREQEEI 477

Query: 233 ELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNT 292
             + EK + + ++   +    RQ  +M      +  +++    + E++ ++ +   EQ  
Sbjct: 478 WRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQE- 536

Query: 293 FLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ 352
               K+ + E  +     K+ E +            E  + + ++ R+  KI+ + + ++
Sbjct: 537 ---EKIREQEEMMQEQEEKMGEQE------------EKMQEQEKMRRQEEKIREQEEKIR 581

Query: 353 SDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMK 412
              E ++   E      + +  E IR+ +   +E  +K+   +++  E E      EKM+
Sbjct: 582 EQKEKIREQEEK-----IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE------EKMQ 630

Query: 413 VEHDVWRQSEKDQYEEKLRASQMAEEI 439
            + +  R+ E+  +E+++R  Q  E++
Sbjct: 631 EQEEKMRRQEEKMWEQEVRLRQQEEKM 657



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 54/264 (20%), Positives = 117/264 (44%), Gaps = 26/264 (9%)

Query: 32  QKMLIDERLRCEHHKANYQTLKA--EHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLE 89
           +K   +E++R E  K   Q  K   +  +++ +  K++ + K ++ +++   E+ ++  E
Sbjct: 397 EKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 455

Query: 90  ELRGELVE------KTKDLEEMKLQILTPQKLELLRAQIQQ----------------ELE 127
           E R E  E      K ++ EE+  Q     + E +R Q ++                E E
Sbjct: 456 EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE 515

Query: 128 TPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARL 187
             M  +   + E+ EK R    K+R +   ++ + E   E+  ++ ++ K++ + E  R 
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIRE 575

Query: 188 EEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVEN 247
           +E+K   + + +     K  ++ E++ RE+  + Q+ +    E  E   E+E    + E 
Sbjct: 576 QEEKIREQKEKIREQEEKIWEQEEKI-REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 634

Query: 248 AQRIQVRQLAEMQATVRSLEAEKQ 271
             R Q  ++ E +  +R  E + Q
Sbjct: 635 KMRRQEEKMWEQEVRLRQQEEKMQ 658



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 46/192 (23%), Positives = 91/192 (47%), Gaps = 12/192 (6%)

Query: 55  EHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQK 114
           E  R Q E V  Q E  H   EK  +QE+     EE   E  EK ++ EE   +      
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE------ 541

Query: 115 LELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILD 174
               + ++ QE E  M E+   + E+ EK R    K+R +   ++ + E  +E+  +I +
Sbjct: 542 ----QEEMMQEQEEKMGEQEEKMQEQ-EKMRRQEEKIREQEEKIREQKEKIREQEEKIWE 596

Query: 175 -EGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAE 233
            E KI+ + E+ + +E+K   + + +     K  ++ E++ R++  + ++   L  +  +
Sbjct: 597 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656

Query: 234 LKAEKENSEAQV 245
           ++  +E+ EA +
Sbjct: 657 MQEHQEHLEAAI 668


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2079 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2134 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2247

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2248 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2359 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2417 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2476 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2591 NQRLREQLQLLEEQHR 2606



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1812 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 1926

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2040

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2041 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2097

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2098 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2148

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2149 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2204

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2205 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2309

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483

Query: 693  L 693
            L
Sbjct: 2484 L 2484



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2243

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2298

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2299 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2469

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2470 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2514

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2515 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625

Query: 528  L 528
            L
Sbjct: 2626 L 2626



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1816

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 1874

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 1875 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 1930

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 1931 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 1981

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 1982 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2038 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2077

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2123

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2184 VEQELTTLRLQLEETDHQKN 2203



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1587

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1756

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1817 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 1869

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 1926

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2107 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1456 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1491

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1492 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1548

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1667

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1668 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1721 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1774

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1775 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1829 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 1884

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1464 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 1876

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 1877 RRRLEEQAAQH 1887



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1313

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1314 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1372 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1421 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1534

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1535 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1590

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1639

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 601  V 601
            +
Sbjct: 1700 L 1700



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 1018 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1196

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1249

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1365

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1417

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1418 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1473

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEE 1495



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 912  ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 971

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 972  LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 1031

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1032 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1081

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1201

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1261

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1378

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1379 HAQAKAQAEREAKELQQRMQE-EVVRREE 1406


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2083 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2138 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2251

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2252 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2303

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2363 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2421 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2480 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2594

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2595 NQRLREQLQLLEEQHR 2610



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1816 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 1930

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 1989

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2044

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2045 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2101

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2102 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2152

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2153 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2208

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2209 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2313

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2367

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487

Query: 693  L 693
            L
Sbjct: 2488 L 2488



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2247

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2302

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2303 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2354

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2473

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2474 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2518

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2519 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629

Query: 528  L 528
            L
Sbjct: 2630 L 2630



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1820

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 1878

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 1879 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 1934

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 1935 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 1985

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 1986 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2042 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2081

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2127

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2188 VEQELTTLRLQLEETDHQKN 2207



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1591

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1760

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1821 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 1873

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 1930

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2111 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2166

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2213



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1460 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1495

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1496 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1552

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1671

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1672 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1725 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1778

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1779 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1832

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1833 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 1888

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1468 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1584 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 1880

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 1881 RRRLEEQAAQH 1891



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1140 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1199

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1200 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1317

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1318 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1376 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1425 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1538

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1539 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1594

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1643

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 601  V 601
            +
Sbjct: 1704 L 1704



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 1022 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1081

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1082 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1141

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1142 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1200

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1201 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1253

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1369

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1421

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1422 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1477

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEE 1499



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 916  ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 975

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 976  LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 1035

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1036 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1085

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1146 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1205

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1206 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1265

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1266 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1325

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1326 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1382

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1383 HAQAKAQAEREAKELQQRMQE-EVVRREE 1410


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2079 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2134 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2247

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2248 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2359 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2417 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2476 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2591 NQRLREQLQLLEEQHR 2606



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1812 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 1926

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2040

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2041 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2097

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2098 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2148

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2149 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2204

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2205 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2309

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483

Query: 693  L 693
            L
Sbjct: 2484 L 2484



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2243

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2298

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2299 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2469

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2470 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2514

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2515 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625

Query: 528  L 528
            L
Sbjct: 2626 L 2626



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1816

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 1874

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 1875 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 1930

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 1931 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 1981

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 1982 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2038 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2077

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2123

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2184 VEQELTTLRLQLEETDHQKN 2203



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1587

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1756

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1817 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 1869

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 1926

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2107 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1456 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1491

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1492 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1548

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1667

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1668 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1721 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1774

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1775 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1829 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 1884

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1464 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 1876

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 1877 RRRLEEQAAQH 1887



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1313

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1314 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1372 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1421 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1534

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1535 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1590

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1639

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 601  V 601
            +
Sbjct: 1700 L 1700



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 1018 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1196

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1249

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1365

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1417

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1418 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1473

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEE 1495



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 912  ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 971

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 972  LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 1031

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1032 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1081

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1201

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1261

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1378

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1379 HAQAKAQAEREAKELQQRMQE-EVVRREE 1406


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2047 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2102 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2215

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2216 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2267

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2327 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2385 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2444 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2558

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2559 NQRLREQLQLLEEQHR 2574



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1780 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 1894

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 1953

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2008

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2009 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2065

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2066 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2116

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2117 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2172

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2173 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2277

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2331

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451

Query: 693  L 693
            L
Sbjct: 2452 L 2452



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2211

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2266

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2267 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2318

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2437

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2438 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2482

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2483 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593

Query: 528  L 528
            L
Sbjct: 2594 L 2594



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1784

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 1842

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 1843 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 1898

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 1899 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 1949

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 1950 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2006 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2045

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2091

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2152 VEQELTTLRLQLEETDHQKN 2171



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1555

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1666

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1724

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1785 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 1837

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 1894

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2075 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2130

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2177



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1424 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1459

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1460 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1516

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1635

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1636 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1689 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1742

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1743 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1796

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1797 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 1852

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1432 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1547

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1548 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1607

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 1844

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 1845 RRRLEEQAAQH 1855



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1104 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1163

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1164 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1281

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1282 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1340 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1389 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1502

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1503 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1558

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1607

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 601  V 601
            +
Sbjct: 1668 L 1668



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 986  ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1045

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1046 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1105

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1106 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1164

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1165 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1217

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1333

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1385

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1386 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1441

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEE 1463



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 880  ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 939

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 940  LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 999

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1000 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1049

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1110 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1169

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1170 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1229

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1230 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1289

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1290 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1346

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1347 HAQAKAQAEREAKELQQRMQE-EVVRREE 1374


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2216 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2271 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2384

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2385 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2436

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2496 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2554 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2613 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2727

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2728 NQRLREQLQLLEEQHR 2743



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1949 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 2063

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 2122

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2177

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2178 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2234

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2235 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2285

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2286 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2341

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2342 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2446

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2500

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620

Query: 693  L 693
            L
Sbjct: 2621 L 2621



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2380

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2435

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2436 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2487

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2606

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2607 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2651

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2652 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762

Query: 528  L 528
            L
Sbjct: 2763 L 2763



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1953

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 2011

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 2012 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 2067

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 2068 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 2118

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 2119 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2175 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2214

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2260

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2321 VEQELTTLRLQLEETDHQKN 2340



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1724

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1893

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1954 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 2006

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 2063

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2244 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2299

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1593 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1628

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1629 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1685

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1804

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1805 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1858 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1911

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1912 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1965

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1966 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 2021

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1601 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1716

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1717 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 2013

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 2014 RRRLEEQAAQH 2024



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1273 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1332

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1333 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1450

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1451 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1508

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1509 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1558 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1671

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1672 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1727

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1776

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 601  V 601
            +
Sbjct: 1837 L 1837



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 1155 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1214

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1215 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1274

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1275 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1333

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1334 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1386

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1502

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1554

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1555 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1610

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEE 1632



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 1049 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 1108

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 1109 LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 1168

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1169 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1218

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1279 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1338

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1339 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1398

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1399 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1458

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1459 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1515

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1516 HAQAKAQAEREAKELQQRMQE-EVVRREE 1543


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  108 bits (271), Expect = 1e-23
 Identities = 146/616 (23%), Positives = 275/616 (44%), Gaps = 74/616 (12%)

Query: 39   RLRCEHHKANYQTL--KAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL------LEE 90
            R R E   A    L  +A   RLQ E      E  H F  +Q +QE  Q L      L++
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAE------EKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 91   LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNK 150
            LRGE     +  EE +       +++  R   Q   +    ER +   EE  + RA    
Sbjct: 2057 LRGEAEAARRAAEEAE-----EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQL-----LNVDLTK 205
               +   L+ E E +    A+       + ++  A +E+ K+     L     +  +LT 
Sbjct: 2112 AAEK---LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168

Query: 206  DSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRS 265
               ++E+   +K  L ++L+ L+AE  E   ++   E ++ +  R+Q+ +L++++A +  
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV-RVQMEELSKLKARI-- 2225

Query: 266  LEAEKQSANLR-AERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEIT 324
             EAE ++  LR  +  ++ LQ  +E       K+ +   E   LS   +E     +L   
Sbjct: 2226 -EAENRALILRDKDNTQRFLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLAEE 2277

Query: 325  DIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVE--HHKVLLVEKDRELIRKVQA 382
            D+  + A A+  L+ +   +Q E   L+++ E+L+   E    +   +++D+E + +  A
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336

Query: 383  AKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK 442
             + +G+Q+   L+ E+       A+ E++K+      +++    E+  R  + AEEI  K
Sbjct: 2337 EETQGFQR--TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394

Query: 443  ELQSVRLKLQQQIVTIENAEKEKNENSD----LKQQISSLQIQVTSLAQSENDL-LNSNQ 497
             L    L  Q+++  ++  E ++ ++      L++ I+ L+ +   L Q    L L S +
Sbjct: 2395 -LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453

Query: 498  MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLE-EKHKLHERITDREEKYNQA 556
            M     E+L QE     +QA +    +EK    ++ +++E EK KL +   D   K  Q 
Sbjct: 2454 MQTVQQEQLLQE-----TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 557  KEKLQR------------AAIAQKKRKSLHENK--LKRLQEKVEVLEAKKEELET----E 598
            +E+ QR             A  ++ R+  HE +  ++R QE+++ LE ++ + E     E
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2568

Query: 599  NQVLNRQNVPFEDYTR 614
            NQ L  Q    E+  R
Sbjct: 2569 NQRLREQLQLLEEQHR 2584



 Score =  108 bits (270), Expect = 2e-23
 Identities = 157/721 (21%), Positives = 314/721 (43%), Gaps = 103/721 (14%)

Query: 28   QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
            +++ Q+ L +E       +A  + + AE      E  +L+ E +    EK+ + E+L+ L
Sbjct: 1790 EAKRQRQLAEED--AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847

Query: 88   LEE-------LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEE 140
             E+       L  +  +   D+EE   Q+      EL R   +  +E  +R+R R ++EE
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ--KGLVEDTLRQR-RQVEEE 1904

Query: 141  VEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEE--DKEELRNQL 198
            +   +A + K       L+ E    +      L   K + E E AR  +   +EE R + 
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRRRE 1963

Query: 199  LNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAE 258
                + K     E+ AR++    ++++ L+A+V E +  +E +E   E+A+++Q+ Q   
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--ESARQLQLAQ--- 2018

Query: 259  MQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
             +A  + L+AE+++     ++ E+ELQ + +Q   ++++L          + + +E +  
Sbjct: 2019 -EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR-- 2075

Query: 319  NKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIR 378
                    + E A+++ ++E      QS  +  Q+  +   AA +  K    E ++E  R
Sbjct: 2076 -----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK----EAEQEAAR 2126

Query: 379  KVQAAKEEGYQKLVVLQDEKLELENRLAD---LEKMKVEHDVWRQSEKDQYEEKLRASQM 435
            + QA +    QK     D ++E   + A+    +K +VE ++   + + Q EE      +
Sbjct: 2127 RAQAEQAALRQKQAA--DAEMEKHKKFAEQTLRQKAQVEQEL--TTLRLQLEETDHQKNL 2182

Query: 436  AEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLA------QSE 489
             +E    ELQ  RLK +        A +   + S +++++ S+++Q+  L+      ++E
Sbjct: 2183 LDE----ELQ--RLKAE--------ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228

Query: 490  NDLL------NSNQMLKEMVERLK-------------QECRNFRSQAEKAQLEAEKTLEE 530
            N  L      N+ + L+E  E++K             QE    R  AE+  L  ++ L E
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-DLAQQRALAE 2287

Query: 531  KQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEA 590
            K ++   +  +   R+    E   Q KE      +AQ++ + L E+K +  Q+  E  + 
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKE------LAQEQARRLQEDKEQMAQQLAEETQG 2341

Query: 591  KKEELETENQ-------VLNRQNVPFEDYTRLQKRL-KDIQRRHNEFRSLILVPNMPPTA 642
             +  LE E Q          R  +   + +R Q R  +D QR   +   +    +    A
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401

Query: 643  SINPVSFQSSAMVPSMELPFPP----------HMQEEQHQRELSLLRKRLEELETTQRKQ 692
            +   V+   +  +   +                 ++E+ Q+E  LL+ + EE++T Q++Q
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461

Query: 693  L 693
            L
Sbjct: 2462 L 2462



 Score =  103 bits (257), Expect = 5e-22
 Identities = 134/541 (24%), Positives = 242/541 (44%), Gaps = 78/541 (14%)

Query: 27   SQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQL 86
            +Q+  Q     E+LR E  +   +  +AE   L+ +        KH    +QT ++K Q+
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162

Query: 87   LLE----ELRGELVEKTKDLEEMKLQILTPQKLELLR--AQIQQELETPMRERFRNLDE- 139
              E     L+ E  +  K+L + +LQ L  +  E  R  +Q+++EL + +R +   L + 
Sbjct: 2163 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2221

Query: 140  ----EVEKYRAVYNKLRYEHTFLKSEFEHQK---EEYARILDEGKIKYESEIARLEEDKE 192
                E E    +         FL+ E E  K   EE AR+    +     E ARL +  E
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-----EAARLRQLAE 2276

Query: 193  ELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
            E        DL +     E++ +EK+   Q+   L+AE   L+ +KE ++ Q    Q  +
Sbjct: 2277 E--------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2328

Query: 253  ---VRQLA-EMQATVRSLEAEKQ---SANLRAERL--------------EKELQSSSEQN 291
                +QLA E Q   R+LEAE+Q     +  AERL              E++ Q   +Q 
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388

Query: 292  TFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGL 351
              +  KLH+ E       + V+ L+   +    D +     A +ELERE+ K+Q E   L
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAKLL 2447

Query: 352  QSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM 411
            Q  +E ++            +  +L+++ QA +    Q  +  +D  L+ E R  + EK 
Sbjct: 2448 QLKSEEMQTV----------QQEQLLQETQALQ----QSFLSEKDSLLQRE-RFIEQEKA 2492

Query: 412  KVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSD- 470
            K+E           +++++  +Q   E  +++ Q +  + Q+ + ++E A + ++E  + 
Sbjct: 2493 KLE---------QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543

Query: 471  LKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEK---AQLEAEKT 527
            ++++   LQ       Q E  L   NQ L+E ++ L+++ R   + +E+   +Q+ A KT
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603

Query: 528  L 528
            L
Sbjct: 2604 L 2604



 Score =  102 bits (255), Expect = 9e-22
 Identities = 149/620 (24%), Positives = 258/620 (41%), Gaps = 101/620 (16%)

Query: 53   KAEHTRLQNEHVKLQNELKHLFNEKQTQQ-----------EKLQLLLEELRGELVEKTKD 101
            +A   RLQ E V  Q  L     EKQ ++           E+  +   EL  + +EK + 
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 102  LEEMKLQ--ILTPQKLELLRAQIQQ--ELETPMRERFRNLDEEV-------EKYRAVYNK 150
            L E   Q  +   Q+L  LRA+ +Q  +    + E    L  E        ++  A   K
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737

Query: 151  LRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRV 210
            +R E   L +     +EE     ++ K + E+E  R  E  EE         L +++KR 
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LAEEAKRQ 1794

Query: 211  EQLAREKV---------YLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQA 261
             QLA E            L +KL  +  E   LK E E +  + E A+  ++R+LAE +A
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKE-AENERLRRLAEDEA 1852

Query: 262  TVRSLEAEKQSANLRAE------RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKEL 315
              R    E+Q+A  +A+      +L K   S  E+   L+    +  R++     ++  L
Sbjct: 1853 FQRR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILAL 1908

Query: 316  KHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRE 375
            K S +        + A  K+ELE E  +I+S  +      E  +      + L  E++R 
Sbjct: 1909 KASFE--------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER- 1959

Query: 376  LIRKVQAAKEEGYQKLVVLQDEKL-ELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQ 434
              R+ +A  EE  QK +  ++E   + +  L ++E++K + +  R+  +   +E  R  Q
Sbjct: 1960 --RRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015

Query: 435  MAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLN 494
            +A+E  +K LQ+                +EK     ++Q+   LQ       Q E  +L+
Sbjct: 2016 LAQEAAQKRLQA----------------EEKAHAFAVQQKEQELQ----QTLQQEQSVLD 2055

Query: 495  SNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYN 554
              +   E   R  +E    R QAE+   ++ + +EE             ER+    E+  
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA------------ERLKQSAEE-- 2101

Query: 555  QAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK---EELETE----NQVLNRQNV 607
            QA+ + Q  A A+K RK   +   +R Q +   L  K+    E+E       Q L ++  
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161

Query: 608  PFEDYTRLQKRLKDIQRRHN 627
              ++ T L+ +L++   + N
Sbjct: 2162 VEQELTTLRLQLEETDHQKN 2181



 Score =  101 bits (251), Expect = 3e-21
 Identities = 156/707 (22%), Positives = 290/707 (41%), Gaps = 84/707 (11%)

Query: 38   ERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE 97
            E LR +  +A  +  +AE  R +   V L+           T Q   +  L+  R    E
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALE-----------TAQRSAEAELQSKRASFAE 1565

Query: 98   KTKDLE----EMKLQILTPQKLELLRAQIQQELETPMRERFRNLDE------EVEKYRAV 147
            KT  LE    E  + +   ++    RAQ Q E E    E  R L+       E  + R  
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625

Query: 148  YNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDS 207
              ++  + +  ++E E QKEE  R         E+      E++   + +L   +L K  
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQR 1676

Query: 208  KRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-----IQVRQLAEMQAT 262
            +  E  A++++   Q+L  L AE  + + +++  E ++   QR      Q RQ  E++A 
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ--ELEAE 1734

Query: 263  VRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
            +  + AE +       R E+E +S+SE++   +       RE+   +++++ L    K +
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794

Query: 323  ITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA 382
                + + AR ++E ER    + +E      +   LK   E   + L EK+ E  R  + 
Sbjct: 1795 RQLAEEDAARQRAEAER----VLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRL 1847

Query: 383  AKEEGYQKLVVLQD---EKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI 439
            A++E +Q+  + +     K ++E RLA L K     D   + +K   E+ LR  +  EE 
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEE 1904

Query: 440  T-----------------RKELQSVRLKLQQQIVTIENAEKEKNENSDL----KQQISSL 478
                                EL  +R   +  + + E AE E      L    +++    
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964

Query: 479  QIQVTSLAQSENDLLNSNQMLKEMVERLK---QECRNFRSQAEKA---QLEAEKTLEEKQ 532
            + +V     +E +     +   E VERLK   +E R  R +AE+    QL+  +   +K+
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024

Query: 533  IQWLEEKHKLHERITDREEKYNQAKEKL---QRAAIAQKKRKSLHENKLKRLQEKVEVLE 589
            +Q  E+ H    +  ++E +    +E+    Q    A+  R++  E +  R+Q + E  +
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084

Query: 590  AKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSF 649
            ++++  E E     +Q+   +   R Q +    ++   E             A++     
Sbjct: 2085 SRRQVEEAERL---KQSAEEQAQARAQAQAA-AEKLRKEAEQEAARRAQAEQAALRQKQA 2140

Query: 650  QSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEEL 696
              + M    +       Q+ Q ++EL+ LR +LEE +  +    EEL
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 127/581 (21%), Positives = 252/581 (43%), Gaps = 68/581 (11%)

Query: 58   RLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEM-KLQILTPQKLE 116
            R+Q E V+ +        +K++ QE+LQ L +    E+  K +  E   + ++   +++ 
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433

Query: 117  LLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEG 176
            ++R Q    LE   R+R    + E++  RA              E E QK +        
Sbjct: 1434 VVRLQ----LEATERQR-GGAEGELQALRA-----------RAEEAEAQKRQ-------- 1469

Query: 177  KIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKA 236
              + E+E  R +   E  R +   V+L    K   + AREK    Q L+ L  +  E  A
Sbjct: 1470 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE--A 1526

Query: 237  EKENSEAQVENAQRIQV-------RQLAEMQATVRS-------LEAEKQSANLRAERLEK 282
            E+   +A+VE A+++QV          AE+Q+   S       LE   Q  ++   +L +
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586

Query: 283  ELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN 342
            E +  ++Q         +AERE+     K  E     +L+  ++  + + A++E E+++ 
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRL-RLQAEEVAQQKSLAQAEAEKQKE 1645

Query: 343  KIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQD-EKLEL 401
            + + E    +   +  + AV   ++     ++EL ++ Q A+    Q+L   Q+  +L  
Sbjct: 1646 EAERE---ARRRGKAEEQAVRQREL----AEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698

Query: 402  ENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENA 461
            E    + ++  +E ++ R        E   A+Q  +E+   EL  VR +++  + +   A
Sbjct: 1699 ETEQGEQQRQLLEEELARLQ-----REAAAATQKRQEL-EAELAKVRAEMEVLLASKARA 1752

Query: 462  EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQ 521
            E+E    S+  +Q      ++ + A    +L      L+ + E  K++ +     A + +
Sbjct: 1753 EEESRSTSEKSKQ------RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1806

Query: 522  LEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQK-KRKSLHENKLKR 580
             EAE+ L EK +  + E  +L        ++     E+L+R A  +  +R+ L E   + 
Sbjct: 1807 AEAERVLAEK-LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---QA 1862

Query: 581  LQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKD 621
             Q K ++ E   +  +  +  L RQ    ED  R ++++++
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 104/551 (18%), Positives = 228/551 (41%), Gaps = 57/551 (10%)

Query: 121  QIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKY 180
            ++ ++     RER   ++  +EK R    +L   H   K++ E + +E  + + E  ++ 
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382

Query: 181  ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKEN 240
            E      ++ K  ++ +L  +  + +++ ++  AR+     +    +E E+  ++ + E 
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441

Query: 241  SEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL-INKLH 299
            +E Q   A+     +L  ++A     EA+K+ A   AERL +++Q  S++     +    
Sbjct: 1442 TERQRGGAEG----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1497

Query: 300  KAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERN--------------KIQ 345
            + + E      K + L+   +L +   + E    ++E+ER R               ++Q
Sbjct: 1498 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1557

Query: 346  SELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQA------AKEEGYQKL-------- 391
            S+          L+ +++   V + +   E  R+ Q       A+EE  ++L        
Sbjct: 1558 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1617

Query: 392  ----VVLQDEKLELENRLA--DLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQ 445
                + LQ E++  +  LA  + EK K E +   +      E+ +R  ++AE+   K+ Q
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 446  SVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVER 505
                  QQ++   +   + + E    +QQ   L+ ++  L +         Q L+  + +
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737

Query: 506  LKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAI 565
            ++ E     +   +A+ E+  T E+ + +   E  +  E   +       A+E  ++  +
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797

Query: 566  AQKKRKSLHENKLKRLQEKVEVL----------EAKKEELETENQVLNRQNVPFEDYTRL 615
            A++          + L EK+  +          E   +E E EN+ L R     ED    
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL---AEDEAFQ 1854

Query: 616  QKRLKDIQRRH 626
            ++RL++   +H
Sbjct: 1855 RRRLEEQAAQH 1865



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 139/601 (23%), Positives = 267/601 (44%), Gaps = 74/601 (12%)

Query: 39   RLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVE- 97
            R + E  +  +  L+ E    Q    +LQ        E +  +E++  LLE  +  L + 
Sbjct: 1114 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1173

Query: 98   --KTKDLEEMKLQI------LTPQKLELLRAQIQQELETPM--------RERFRN---LD 138
              + ++LE++  Q+        P    L  A+ +QE    M        RE+ R    L 
Sbjct: 1174 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233

Query: 139  EEVEKY-RAVYNKLRYEHTFLKS--EFEHQKEEYARILDEGKIKYESEIARLEEDKEELR 195
            EE+E++   V    R+   ++ +  ++E Q   Y   L+   +   ++  +++   E + 
Sbjct: 1234 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQSGSESVI 1291

Query: 196  NQLLNVDLTKDSKRVEQLAREKV-YLCQKLKGLEAE---VAELKAEKENSEAQVENAQRI 251
             +   VDL      +  L  + + ++ + L+ +E E     + +AE+    A+VE A   
Sbjct: 1292 QEY--VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1349

Query: 252  QVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLH-KAEREINTLSS 310
            Q RQLAE  A           A  +AER  KELQ   ++      +    A+++  ++  
Sbjct: 1350 Q-RQLAEAHA----------QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398

Query: 311  KVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQ---SDNEILKAAVEHHKV 367
            ++++L+ S++ EI       AR     ER R +I+ E+  ++      E  +   E    
Sbjct: 1399 ELQQLRQSSEAEIQ----AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454

Query: 368  LLVEKDRELIRKVQAAKEEGYQKLVVLQDE---KLELENRLADLEKMKVEHDVWRQSEKD 424
             L  +  E   + + A+EE  +    +QDE   K + E  LA   ++K E +  R+ ++ 
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVKAEAEAAREKQRA 1512

Query: 425  -QYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVT 483
             Q  E+LR    AEE  R+  Q+   + +Q  V +E A  +++  ++L+ + +S   +  
Sbjct: 1513 LQALEELRL--QAEEAERRLRQAEVERARQVQVALETA--QRSAEAELQSKRASFAEKTA 1568

Query: 484  SLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLH 543
             L +S  +   +   L+E  ER  Q+    +++AE+A+ EAE+ LE  Q+       K +
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQ----QAEAERAREEAERELERWQL-------KAN 1617

Query: 544  ERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKR---LQEKVEVLEAKKEELETENQ 600
            E +  R +    A++K    A A+K+++       +R    ++ V   E  ++ELE + Q
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 601  V 601
            +
Sbjct: 1678 L 1678



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 113/502 (22%), Positives = 211/502 (42%), Gaps = 60/502 (11%)

Query: 230  EVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAE------RLEKE 283
            E A+  AE++ ++A+VE   +   R  AE +  +   E    +  LR+E      +LE+ 
Sbjct: 996  ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1055

Query: 284  LQSSS------EQNTFLINKLHKAEREINTLSSKVKELK----HSNKLEITDIKLETARA 333
               S+      +  + +I     AE  +     ++KE +       +LE T   L+  RA
Sbjct: 1056 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1115

Query: 334  KSELERER-NKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLV 392
            ++E ++   + ++ EL G Q   E L+      + + VE+ RE + ++    +    +  
Sbjct: 1116 QAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD 1174

Query: 393  VLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQ 452
            V Q E  +L  +L    +       W Q  + + +E+++A  +A+       Q+VR +L+
Sbjct: 1175 VRQRELEQLGRQLRYYRESADPLGAWLQDAR-RRQEQIQAMPLADS------QAVREQLR 1227

Query: 453  QQIVTIENAEK--EK------------NENSDLKQQISSLQIQ---VTSLAQSENDLLNS 495
            Q+   +E  E+  EK            N   D + Q+ + + Q   V S A+       S
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287

Query: 496  NQMLKEMVERLK--QECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKY 553
              +++E V+      E     SQ  K   E  + +EE+  + L E+ +  ER  +R  + 
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER--ERLAEV 1343

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYT 613
              A EK ++ A A  + K+  E + K LQ++++    ++EE   + Q   R         
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS-------- 1395

Query: 614  RLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQR 673
             +Q+ L+  Q R +    +         A  + +  +    V  ++L      Q    + 
Sbjct: 1396 -IQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE-ATERQRGGAEG 1451

Query: 674  ELSLLRKRLEELETTQRKQLEE 695
            EL  LR R EE E  +R+  EE
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEE 1473



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 102/509 (20%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 261  ATVRSLEAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHS 318
            AT R+L+ E+Q   L +  L  +  L+ S +   F       AERE  + S   ++L  S
Sbjct: 890  ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 949

Query: 319  NKL-------------EITDIKL-------------------ETARAKSELERERNKIQS 346
             +              E+ DI+L                   E AR  ++   E+ K Q+
Sbjct: 950  LEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA 1009

Query: 347  ELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLA 406
            E++GL     + + + E  KVL + +       +++  E        L   KLE    L+
Sbjct: 1010 EVEGL--GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLS 1059

Query: 407  D--LEKMKVEHDVWRQSEKDQ-----YEEKLRASQMAE------EITRKELQSVRLKLQQ 453
               LEK+K    V R ++  +     +EE+L+ +Q         E T+  L+ +R + + 
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119

Query: 454  QIVTI-----------ENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEM 502
            Q  T            E  E+ +  + +   ++   + +V  L +    +L    + +  
Sbjct: 1120 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1179

Query: 503  VERLKQECRNFRSQAEKAQL---EAEKTLEEKQIQWLEEKHKLHERITDRE------EKY 553
            +E+L ++ R +R  A+       +A +  E+ Q   L +   + E++   +      E++
Sbjct: 1180 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1239

Query: 554  NQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVL--EAKKEELETENQVLNRQNVP--- 608
             +  E+ QR A         +E +L   + ++E +   AKK ++++ ++ + ++ V    
Sbjct: 1240 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1299

Query: 609  -FEDYTRLQ----KRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFP 663
             + + T L     K + +  RR  E   L           +  V    +A+    +L   
Sbjct: 1300 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1356

Query: 664  PHMQEEQHQRELSLLRKRLEELETTQRKQ 692
                + Q +RE   L++R++E E  +R++
Sbjct: 1357 HAQAKAQAEREAKELQQRMQE-EVVRREE 1384


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,705,291
Number of Sequences: 37866
Number of extensions: 1118255
Number of successful extensions: 23858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 535
Number of HSP's successfully gapped in prelim test: 1398
Number of HSP's that attempted gapping in prelim test: 7281
Number of HSP's gapped (non-prelim): 7847
length of query: 701
length of database: 18,247,518
effective HSP length: 109
effective length of query: 592
effective length of database: 14,120,124
effective search space: 8359113408
effective search space used: 8359113408
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.