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Search of human proteins with 4557481
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP),
member 2 [Homo sapiens]
(1545 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 3039 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 1369 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1310 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 1235 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 1234 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 1227 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 999 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 964 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 830 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 726 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 724 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 717 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 717 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 709 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 702 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 697 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 653 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 646 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 646 0.0
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 591 e-168
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 443 e-124
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 325 2e-88
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 280 1e-74
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 240 9e-63
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 218 5e-56
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 202 3e-51
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 182 3e-45
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 168 3e-41
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 168 3e-41
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 159 2e-38
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 3039 bits (7880), Expect = 0.0
Identities = 1545/1545 (100%), Positives = 1545/1545 (100%)
Query: 1 MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS 60
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS
Sbjct: 1 MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS 60
Query: 61 TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS 120
TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS
Sbjct: 61 TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS 120
Query: 121 RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI 180
RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI
Sbjct: 121 RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI 180
Query: 181 FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS 240
FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS
Sbjct: 181 FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS 240
Query: 241 KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG 300
KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG
Sbjct: 241 KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG 300
Query: 301 TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG 360
TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG
Sbjct: 301 TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG 360
Query: 361 YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET 420
YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET
Sbjct: 361 YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET 420
Query: 421 VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL 480
VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL
Sbjct: 421 VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL 480
Query: 481 STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS 540
STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS
Sbjct: 481 STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS 540
Query: 541 QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI 600
QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI
Sbjct: 541 QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI 600
Query: 601 SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD 660
SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD
Sbjct: 601 SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD 660
Query: 661 IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL 720
IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL
Sbjct: 661 IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL 720
Query: 721 FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD 780
FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD
Sbjct: 721 FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD 780
Query: 781 IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV 840
IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV
Sbjct: 781 IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV 840
Query: 841 EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS 900
EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS
Sbjct: 841 EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS 900
Query: 901 ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG 960
ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG
Sbjct: 901 ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG 960
Query: 961 KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR 1020
KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR
Sbjct: 961 KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR 1020
Query: 1021 DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI 1080
DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI
Sbjct: 1021 DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI 1080
Query: 1081 VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF 1140
VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF
Sbjct: 1081 VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF 1140
Query: 1141 YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW 1200
YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW
Sbjct: 1141 YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW 1200
Query: 1201 ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS 1260
ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS
Sbjct: 1201 ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS 1260
Query: 1261 EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
Sbjct: 1261 EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
Query: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII
Sbjct: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
Query: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG
Sbjct: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
Query: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD
Sbjct: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
Query: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF 1545
SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
Sbjct: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF 1545
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 1369 bits (3544), Expect = 0.0
Identities = 736/1545 (47%), Positives = 1024/1545 (66%), Gaps = 54/1545 (3%)
Query: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
Query: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
Query: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
Query: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
Query: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
Query: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
Query: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
Query: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
Query: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IKG+ AYVPQQ+WIQN ++
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSL 722
Query: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
++NILFG + E Y+ V++ACALLPDLE+LP GD EIGEKG+NLSGGQKQR+SLARA
Sbjct: 723 RENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAV 782
Query: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Y N DIYL DDPLSAVDAHVGKHIF V+GP G+LK KTR+LVTHSM +LPQVD I+V+
Sbjct: 783 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 842
Query: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
G I E GSY LLA+ G FA+ L+T+ +T + EE+ G+ +E
Sbjct: 843 GGKISEMGSYQELLARDGAFAEFLRTY--------ASTEQEQDAEENGVTGVSGPGKEAK 894
Query: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 895 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 949
Query: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 950 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWT-DDPIVNGT 1008
Query: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 1009 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1065
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1066 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1125
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1126 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1185
Query: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1186 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1245
Query: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1246 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 1433 AGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492
G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDLETD+LIQ+TI+ +F CTV+TIA
Sbjct: 1426 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1485
Query: 1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
HRL+TIMD +V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1486 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1530
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1310 bits (3391), Expect = 0.0
Identities = 717/1559 (45%), Positives = 1012/1559 (64%), Gaps = 73/1559 (4%)
Query: 8 STFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYL 66
S FW+S+ + + DL CF+ ++L W+P +LW+ P LL Y R +L
Sbjct: 12 SKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHL 69
Query: 67 AK-QVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV--LLIQYSRQW 123
+K ++ +G LL + PA + L +G +L+ LLIQY R
Sbjct: 70 SKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQ 129
Query: 124 CVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFISYGFQILILIFS 182
VQ +S L +FW L ++C F++ ++ +G+ S+ F+I + + LI +
Sbjct: 130 GVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILA 188
Query: 183 AFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
F E N + + P + A FLS + + W+ + + GY+ PL +D+W + EE +
Sbjct: 189 CFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDR 248
Query: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEK 294
++ +V ++L +A R+QEK + ++ + PG N + +D ++L +
Sbjct: 249 SQMVV--------QQLLEA----WRKQEKQTARHKASAAPGKN---ASGEDEVLLGARPR 293
Query: 295 KKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRD 354
+K S +KAL TF L S KL+ D+ +F++PQLL +LI F S+
Sbjct: 294 PRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPM 343
Query: 355 TYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKE 414
W G+L A L+F +++QS LQ Y+ F GVK RT IM +Y+KAL ++N ++
Sbjct: 344 APSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRA 403
Query: 415 YTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVI 474
TVGE VNLMSVDAQ+ MD+ F+++LWS+ LQI+L+I+FLW+ LGPSVLAGV MVL+I
Sbjct: 404 STVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLI 463
Query: 475 PINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
P+N ++ K + QVK MK KD R+K+M+EIL+GIK+LK +AWEPSF QV+ +R+ EL+
Sbjct: 464 PLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ 523
Query: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS 594
L + L F + +P LV+++T VYV VD NN+LDA+KAF S++LFNILR PL+
Sbjct: 524 LLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLN 583
Query: 595 MLPMMISSMLQASVSTERLEKYLGGDDLDTSAI-RHDCNFDKAMQFSEASFTWEHDSEAT 653
MLP +IS++ QASVS +R++++L ++LD ++ R + A+ +FTW D T
Sbjct: 584 MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPT 643
Query: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNG 713
+ +++ + G LVAV+GPVG GKSSL+SA+LGEME + G + +KG+ AYVPQQ+WIQN
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNC 703
Query: 714 TIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLAR 773
T+++N+LFG N KRYQQ LEACALL DLEMLPGGD EIGEKGINLSGGQ+QR+SLAR
Sbjct: 704 TLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLAR 763
Query: 774 ATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVV 833
A Y + DI+LLDDPLSAVD+HV KHIF+ V+GP G+L GKTR+LVTH + FLPQ D I+V
Sbjct: 764 AVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIV 823
Query: 834 LGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA-------TVHDGSEEEDD--- 883
L +G + E G Y ALL + G FA FL + P+E+ T +G+E+++
Sbjct: 824 LADGQVSEMGPYPALLQRNGSFAN----FLCNYAPDEDQGHLEDSWTALEGAEDKEALLI 879
Query: 884 DYGLISSVEEIPEDAASITMRRENSFRRTLSR-SSRSNGRHLKSLRNSL---KTRNVNSL 939
+ L + + D + ++++ F R LS SS G+ R L + V
Sbjct: 880 EDTLSNHTDLTDNDPVTYVVQKQ--FMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEA 937
Query: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
K D L + +K G V+ S++ +Y +A+GL + I L +V S A IG+N+W
Sbjct: 938 KADGALTQEEKAA------IGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVW 991
Query: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
LSAWT+D+ D + +R+GVY ALG+ QG V +A A G + A+ +LH+
Sbjct: 992 LSAWTNDAM----ADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQA 1047
Query: 1060 LLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMA 1119
LL+N +R+P FFDTTP+GRI+N F+ DI VD+ L + + F ISTLV+I +
Sbjct: 1048 LLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS 1107
Query: 1120 TPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQ 1179
TP+FT++++PL ++Y VQ FY +TSRQL+RL+SV+RSPIYSHFSETV+G VIRA+
Sbjct: 1108 TPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRS 1167
Query: 1180 QRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVG 1239
+ F ++ ++D NQ+ + +I SNRWL+I +E VGN V F+AL VI R +L+ VG
Sbjct: 1168 RDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVG 1227
Query: 1240 FVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTD-KRPPPDWPSKG 1298
+S +L +T LNW++RM S++E+NIVAVER+ EY+K E EAPWV + RPP WP +G
Sbjct: 1228 LSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRG 1287
Query: 1299 KIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358
+++F NY VRYRP LDLVLR ++ + EK+G+VGRTGAGKSS+T CLFRILEAA G+I
Sbjct: 1288 EVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEI 1347
Query: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSF 1418
IDG+++A IGLHDLR +LTIIPQDPILFSG+LRMNLDPF +YS+E+IW ALEL+HL +F
Sbjct: 1348 RIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTF 1407
Query: 1419 VASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTT 1478
V+S GL + +E G NLS+GQRQL+CL RALLRKS+ILVLDEATAA+DLETDNLIQ T
Sbjct: 1408 VSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQAT 1467
Query: 1479 IQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
I+ +F CTV+TIAHRL+TIMD +V+VLD G + E SP L+ G FY MA++AG+
Sbjct: 1468 IRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 1235 bits (3196), Expect = 0.0
Identities = 666/1447 (46%), Positives = 939/1447 (64%), Gaps = 54/1447 (3%)
Query: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
Query: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
Query: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
Query: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
Query: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
Query: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
Query: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
Query: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
Query: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IKG+ AYVPQQ+WIQN ++
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSL 722
Query: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
++NILFG + E Y+ V++ACALLPDLE+LP GD EIGEKG+NLSGGQKQR+SLARA
Sbjct: 723 RENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAV 782
Query: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Y N DIYL DDPLSAVDAHVGKHIF V+GP G+LK KTR+LVTHSM +LPQVD I+V+
Sbjct: 783 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 842
Query: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
G I E GSY LLA+ G FA+ L+T+ +T + EE+ G+ +E
Sbjct: 843 GGKISEMGSYQELLARDGAFAEFLRTY--------ASTEQEQDAEENGVTGVSGPGKEAK 894
Query: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 895 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 949
Query: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 950 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWT-DDPIVNGT 1008
Query: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 1009 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1065
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1066 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1125
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1126 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1185
Query: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1186 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1245
Query: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1246 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 1433 AGGNLSI 1439
G NL +
Sbjct: 1426 GGENLRV 1432
Score = 91.7 bits (226), Expect = 5e-18
Identities = 106/466 (22%), Positives = 191/466 (40%), Gaps = 31/466 (6%)
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
++ G IVN + D D W + L +I L ++ + + + + ++
Sbjct: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIW-SAPLQVILALYLLWLNLGPSVLAGVAVMVL 475
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIR------AFEHQQRFLKHNE 1187
V V ++ + ++ +E ++G+ V++ AF+ + ++ E
Sbjct: 476 MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
Query: 1188 VRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALN 1247
+++ + S + + W+ LV T A+ + I + + FV N
Sbjct: 536 LKV-LKKSAYLSAVGTFTWVCTPF-LVALCTF---AVYVTIDENNILDAQTAFVSLALFN 590
Query: 1248 ITQ-TLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQ 1306
I + LN L + S I V+++R+ + E P ++RP D I N
Sbjct: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
Query: 1307 VRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIA 1366
+ L GIT I + VVG+ G GKSSL + L ++ G + I G
Sbjct: 651 FTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---- 706
Query: 1367 SIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA-LELAHLKSFVASLQLG 1425
+ +PQ + + SLR N+ F +E +++ ++ L + L G
Sbjct: 707 ---------SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSG 756
Query: 1426 LSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI---QNE 1482
E+ E G NLS GQ+Q + L RA+ + I + D+ +AVD I + +
Sbjct: 757 DRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGM 816
Query: 1483 FAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPF 1528
+ T I + H + + D ++V+ GKI E GS +ELL G F
Sbjct: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
Score = 42.4 bits (98), Expect = 0.004
Identities = 20/35 (57%), Positives = 27/35 (77%)
Query: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
+V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1465
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 1234 bits (3193), Expect = 0.0
Identities = 693/1545 (44%), Positives = 973/1545 (62%), Gaps = 113/1545 (7%)
Query: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
Query: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
Query: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
Query: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
Query: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
Query: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
Query: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
Query: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
Query: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
+ I G LVAV+G Q G
Sbjct: 663 GITFSIPEGALVAVVG---------------------------------------QVGCG 683
Query: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
K ++L ALL +++ + G + KG+NLSGGQKQR+SLARA
Sbjct: 684 KSSLL----------------SALLAEMDKVEG----HVAIKGVNLSGGQKQRVSLARAV 723
Query: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Y N DIYL DDPLSAVDAHVGKHIF V+GP G+LK KTR+LVTHSM +LPQVD I+V+
Sbjct: 724 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 783
Query: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
G I E GSY LLA+ G FA+ L+T+ T E++A EE+ G+ +E
Sbjct: 784 GGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA-------EENGVTGVSGPGKEAK 835
Query: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 836 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 890
Query: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 891 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGT 949
Query: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 950 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1006
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1007 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1066
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1067 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1126
Query: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1127 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1186
Query: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1187 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1246
Query: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1247 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1306
Query: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1307 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1366
Query: 1433 AGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492
G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDLETD+LIQ+TI+ +F CTV+TIA
Sbjct: 1367 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1426
Query: 1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
HRL+TIMD +V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1427 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1471
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 1227 bits (3174), Expect = 0.0
Identities = 685/1545 (44%), Positives = 974/1545 (63%), Gaps = 110/1545 (7%)
Query: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
Query: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
Query: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
Query: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
Query: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
Query: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
Query: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
Query: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
Query: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IKG+ AYVPQQ+WIQN ++
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSL 722
Query: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
++NILFG + E Y+ V++ACAL LP ++ G++
Sbjct: 723 RENILFGCQLEEPYYRSVIQACAL------LPDLEILPSGDR------------------ 758
Query: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
+G+ KTR+LVTHSM +LPQVD I+V+
Sbjct: 759 -----------------TEIGE---------------KTRILVTHSMSYLPQVDVIIVMS 786
Query: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
G I E GSY LLA+ G FA+ L+T+ T E++A EE+ G+ +E
Sbjct: 787 GGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA-------EENGVTGVSGPGKEAK 838
Query: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 839 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 893
Query: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 894 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGT 952
Query: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 953 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1009
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1010 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1069
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1070 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1129
Query: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1130 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1189
Query: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1190 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1249
Query: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1250 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1309
Query: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1310 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1369
Query: 1433 AGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492
G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDLETD+LIQ+TI+ +F CTV+TIA
Sbjct: 1370 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1429
Query: 1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
HRL+TIMD +V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1430 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1474
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 999 bits (2584), Expect = 0.0
Identities = 585/1533 (38%), Positives = 879/1533 (57%), Gaps = 75/1533 (4%)
Query: 23 LPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIE 82
L LCF +T VW+P +LW+L P LL ++ + L+ AK V +GF LI+
Sbjct: 27 LSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMV-LGFALIVLCTS 85
Query: 83 LALVLTEDSGQATVPAVRYT-NPSLYLGTW-LLVLLIQYSRQWCVQKNSWFLSLFWILSI 140
V Q T A + +P+++L T V LI R+ VQ + + + +
Sbjct: 86 SVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFV 145
Query: 141 LCGTFQFQTLIRTLLQGDNSN--LAYSCLFFISYGFQILILIFSA--FSENNESSNN-PS 195
L T Q Q D Y CL + F + L F E+ + SN P
Sbjct: 146 LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPE 205
Query: 196 SIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARR 255
+ A+F S T+ W ++ +GY+RPL +D+W + E ++ LVS+ E R ARR
Sbjct: 206 TGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARR 265
Query: 256 ---ALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
A+ +++ S + P L + SQ + L+K
Sbjct: 266 HNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP------------------------LLK 301
Query: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAAL 372
A+++ F+ L L +++D+F F P+LL L + F D W GYL A+L+F +A
Sbjct: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
Query: 373 IQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLM 432
+Q+ Q L +++R+AI VY+K L LS+ +RK VG+ VNL+SVD Q+L
Sbjct: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 433 DVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNM 492
+ +++ LW ++ IV+ +LW+ LGPS L + V + ++P+N +S K Q + M
Sbjct: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
Query: 493 KNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQL 552
+ KD R ++ + IL K +K+ WE +F D+V +R +EL L L V + FQ+
Sbjct: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
Query: 553 TPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTER 612
+ LV++V F+V+ LV + N ++A+KAF ++T+ NIL + LP I S++QA VS +R
Sbjct: 542 STFLVALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 613 LEKYLGGDDLDTSAIRHDCNFDKA----MQFSEASFTWEHDSEATVRDVNLDIMAGQLVA 668
L +L +++D + + A + A+F W +S + +NL + G L+A
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 669 VIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEK 728
V+GPVG+GKSSL+SA+LGE+ V G ++I+G AYVPQ++W+QN ++ +N+ FG E +
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 729 RYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPL 788
++VLEACAL PD++ P G IGE+G+NLSGGQKQR+SLARA Y+ +YLLDDPL
Sbjct: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
Query: 789 SAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSAL 848
+A+DAHVG+H+FN+V+GP GLL+G TR+LVTH++H LPQ D I+VL NG I E GSY L
Sbjct: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
Query: 849 LAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENS 908
L +KG L R G E G+ +D R ++
Sbjct: 841 LQRKGALVCLLDQ-ARQPGDRGEGETEPGTSTKDP--------------------RGTSA 879
Query: 909 FRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKL---IKKEFIETGKVKFS 965
RR R RS +KS+ K R + + + L + K+ I+ G+VK +
Sbjct: 880 GRRPELRRERS----IKSVPE--KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKAT 933
Query: 966 IYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVG 1025
++L YL+A+G + + F+ VA WLS W D + +Q +R G
Sbjct: 934 VHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQ----QTQAALRGG 989
Query: 1026 VYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
++G LG Q I +F + G AS +L ++LL +++R+P+ FF+ TP G ++NRF+
Sbjct: 990 IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 1049
Query: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
+ TVD +P LRS + G++ +++ +ATP+ T+ ++PL ++Y Q YV +S
Sbjct: 1050 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
Query: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNR 1205
QLRRL+S + S + SH +ET G V+RAF Q F+ N R+D +Q+ F + ++R
Sbjct: 1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 1169
Query: 1206 WLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETN 1265
WLA +EL+GN VF +A V+ + LS VGF +S AL +TQTL W+VR +++E +
Sbjct: 1170 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENS 1229
Query: 1266 IVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDI 1324
IV+VER+ +Y EAPW + P WP G+I+F ++ +RYRPEL L ++G++ I
Sbjct: 1230 IVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKI 1289
Query: 1325 GSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDP 1384
+ EK+G+VGRTGAGKSSL + L R+ EAA G I IDGV IA +GLH LR +++IIPQDP
Sbjct: 1290 HAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDP 1349
Query: 1385 ILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQL 1444
ILF GSLRMNLD +SDE IW ALE LK+ VASL L ++ + G +LS+GQ+QL
Sbjct: 1350 ILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQL 1409
Query: 1445 LCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKV 1504
LCL RALLRK++IL+LDEATAAVD T+ +Q + + FA CTV+ IAHRL ++MD +V
Sbjct: 1410 LCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARV 1469
Query: 1505 MVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
+V+D G++ E GSP +LL G FY +A+E+G+
Sbjct: 1470 LVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 964 bits (2491), Expect = 0.0
Identities = 537/1355 (39%), Positives = 807/1355 (59%), Gaps = 67/1355 (4%)
Query: 194 PSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKA 253
P + A+F S T+ W ++ +GY+RPL +D+W + E ++ LVS+ E R A
Sbjct: 13 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
Query: 254 RR---ALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWL 310
RR A+ +++ S + P L + SQ + L
Sbjct: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP------------------------L 108
Query: 311 MKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTA 370
+KA+++ F+ L L +++D+F F P+LL L + F D W GYL A+L+F +
Sbjct: 109 LKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLS 168
Query: 371 ALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQK 430
A +Q+ Q L +++R+AI VY+K L LS+ +RK VG+ VNL+SVD Q+
Sbjct: 169 ACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQR 228
Query: 431 LMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVK 490
L + +++ LW ++ IV+ +LW+ LGPS L + V + ++P+N +S K Q +
Sbjct: 229 LTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEE 288
Query: 491 NMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVF 550
M+ KD R ++ + IL K +K+ WE +F D+V +R +EL L L V + F
Sbjct: 289 QMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSF 348
Query: 551 QLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVST 610
Q++ LV++V F+V+ LV + N ++A+KAF ++T+ NIL + LP I S++QA VS
Sbjct: 349 QVSTFLVALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSF 407
Query: 611 ERLEKYLGGDDLDTSAIRHDCNFDKA----MQFSEASFTWEHDSEATVRDVNLDIMAGQL 666
+RL +L +++D A+ + A + A+F W +S + +NL + G L
Sbjct: 408 DRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCL 467
Query: 667 VAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFN 726
+AV+GPVG+GKSSL+SA+LGE+ V G ++I+G AYVPQ++W+QN ++ +N+ FG E +
Sbjct: 468 LAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELD 527
Query: 727 EKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDD 786
++VLEACAL PD++ P G IGE+G+NLSGGQKQR+SLARA Y+ +YLLDD
Sbjct: 528 PPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDD 587
Query: 787 PLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYS 846
PL+A+DAHVG+H+FN+V+GP GLL+G TR+LVTH++H LPQ D I+VL NG I E GSY
Sbjct: 588 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQ 647
Query: 847 ALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRE 906
LL +KG L R G E G+ +D R
Sbjct: 648 ELLQRKGALVCLLDQ-ARQPGDRGEGETEPGTSTKDP--------------------RGT 686
Query: 907 NSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKL---IKKEFIETGKVK 963
++ RR R RS +KS+ K R + + + L + K+ I+ G+VK
Sbjct: 687 SAGRRPELRRERS----IKSVPE--KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVK 740
Query: 964 FSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMR 1023
+++L YL+A+G + + F+ VA WLS W D + +Q +R
Sbjct: 741 ATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQ----TQAALR 796
Query: 1024 VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNR 1083
G++G LG Q I +F + G AS +L ++LL +++R+P+ FF+ TP G ++NR
Sbjct: 797 GGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNR 856
Query: 1084 FAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVS 1143
F+ + TVD +P LRS + G++ +++ +ATP+ T+ ++PL ++Y Q YV
Sbjct: 857 FSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVV 916
Query: 1144 TSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITS 1203
+S QLRRL+S + S + SH +ET G V+RAF Q F+ N R+D +Q+ F + +
Sbjct: 917 SSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVA 976
Query: 1204 NRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIE 1263
+RWLA +EL+GN VF +A V+ + LS VGF +S AL +TQTL W+VR +++E
Sbjct: 977 DRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLE 1036
Query: 1264 TNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITC 1322
+IV+VER+ +Y EAPW + P WP G+I+F ++ +RYRPEL L ++G++
Sbjct: 1037 NSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSF 1096
Query: 1323 DIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQ 1382
I + EK+G+VGRTGAGKSSL + L R+ EAA G I IDGV IA +GLH LR +++IIPQ
Sbjct: 1097 KIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQ 1156
Query: 1383 DPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
DPILF GSLRMNLD +SDE IW ALE LK+ VASL L ++ + G +LS+GQ+
Sbjct: 1157 DPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQK 1216
Query: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
QLLCL RALLRK++IL+LDEATAAVD T+ +Q + + FA CTV+ IAHRL ++MD
Sbjct: 1217 QLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCA 1276
Query: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
+V+V+D G++ E GSP +LL G FY +A+E+G+
Sbjct: 1277 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 830 bits (2145), Expect = 0.0
Identities = 490/1362 (35%), Positives = 765/1362 (56%), Gaps = 105/1362 (7%)
Query: 189 ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKR 248
E NP A+ S + + W + + G+KR L +D++ V E +++ L + + +
Sbjct: 7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDK 66
Query: 249 ELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKS 308
E+ +A + D K
Sbjct: 67 EVLRA------------------------------------------------ENDAQKP 78
Query: 309 WLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTY----LWIGYLCA 364
L +A+ K ++ L + L+ + + P L +I++ + D L Y A
Sbjct: 79 SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYA 138
Query: 365 ILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLM 424
+L LI + YF G+++R A+ +Y+KAL LSN+A + T G+ VNL+
Sbjct: 139 TVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLL 198
Query: 425 SVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS 484
S D K VT F+H LW+ LQ + LW E+G S LAG+ V+++++P+ +
Sbjct: 199 SNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLF 258
Query: 485 KTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQC 544
+++ K D R++ MNE+++GI+I+K +AWE SF + + NLRKKE+ +L S L+
Sbjct: 259 SSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG 318
Query: 545 VVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSML-PMMISSM 603
+ + F ++ VTF+ YVL+ S ++ A + F ++TL+ +R +++ P I +
Sbjct: 319 MNLASFFSASKIIVFVTFTTYVLLGS--VITASRVFVAVTLYGAVRLTVTLFFPSAIERV 376
Query: 604 LQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEA-TVRDVNLDIM 662
+A VS R++ +L D++ + + K + + + W+ SE T++ ++ +
Sbjct: 377 SEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVR 436
Query: 663 AGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFG 722
G+L+AV+GPVG+GKSSL+SA+LGE+ HG +++ G AYV QQ W+ +GT++ NILFG
Sbjct: 437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
Query: 723 TEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
++ ++RY++V++ACAL DL++L GDL IG++G LSGGQK R++LARA YQ+ DIY
Sbjct: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
Query: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
LLDDPLSAVDA V +H+F + +L K +LVTH + +L +I++L +G +V+K
Sbjct: 557 LLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
Query: 843 GSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASIT 902
G+Y+ L +F LK D E E P + T
Sbjct: 615 GTYTEFLKSGIDFGSLLKK--------------DNEESEQ------------PPVPGTPT 648
Query: 903 MRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV 962
+R RT S SS + + S R SLK + S +D E V + +E GKV
Sbjct: 649 LRN-----RTFSESSVWSQQ---SSRPSLKDGALES--QDTENVP--VTLSEENRSEGKV 696
Query: 963 KFSIYLEYLQAIGLFSIF-FIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST----DYPA 1017
F Y Y +A + +F F+IL VA++ + WLS W + + N T
Sbjct: 697 GFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT 756
Query: 1018 SQRDMR--VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTT 1075
+ D+ +G+Y L +A +F + V++S LH ++ +IL+AP+ FFD
Sbjct: 757 EKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRN 816
Query: 1076 PTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYV 1135
P GRI+NRF+ DI +DD LP + +I L ++ + + P I ++PLGII++
Sbjct: 817 PIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFI 876
Query: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQK 1195
++ +++ TSR ++RL+S TRSP++SH S ++ GL IRA++ ++R + + D + +
Sbjct: 877 FLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSE 936
Query: 1196 CVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWL 1255
F ++T++RW A+RL+ + + V A +I TL VG LS AL + W
Sbjct: 937 AWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWC 996
Query: 1256 VRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL 1315
VR ++E+E +++VER+ EYT +E EAPW KRPPP WP +G I F+N Y P L
Sbjct: 997 VRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL 1056
Query: 1316 VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLRE 1375
VL+ +T I S EK+G+VGRTGAGKSSL + LFR+ E G+I ID + IGLHDLR+
Sbjct: 1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRK 1115
Query: 1376 KLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
K++IIPQ+P+LF+G++R NLDPFN ++DEE+W AL+ LK + L + E+ E+G
Sbjct: 1116 KMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Query: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
N S+GQRQL+CL RA+LRK++IL++DEATA VD TD LIQ I+ +FAHCTV+TIAHRL
Sbjct: 1176 NFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRL 1235
Query: 1496 HTIMDSDKVMVLDNGKIIECGSPEELLQ-IPGPFYFMAKEAG 1536
+TI+DSDK+MVLD+G++ E P LLQ FY M ++ G
Sbjct: 1236 NTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 726 bits (1873), Expect = 0.0
Identities = 460/1467 (31%), Positives = 750/1467 (51%), Gaps = 181/1467 (12%)
Query: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFS------AFS 185
L L+W+++ + T + ++ L N + + I G + + I F
Sbjct: 137 LFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFF 196
Query: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
N + P + + LS TY W +++I+ +K+P+ L+ + ++ M+
Sbjct: 197 MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMR 256
Query: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDV-- 292
T + + L+D
Sbjct: 257 AVT-----------------------------------------------NYVCLKDAYE 269
Query: 293 EKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASD 352
E+KKK + P WL A+++ F +L S + + D+ F P + ++ ++
Sbjct: 270 EQKKKVADHPNRTPSIWL--AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327
Query: 353 RDT----------------YLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAI 396
+L Y+ A+LLF A ++Q LQ + + + G+ +R A+
Sbjct: 328 TQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGAL 387
Query: 397 MASVYKKALTLS--NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFF 454
+A +Y K L LS NL+ E T+G+ NL++++ +LM LW+ +QI++ +
Sbjct: 388 LAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVIL 447
Query: 455 LWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKY 514
L+ LG S L G V+VL+ PI ++TK Q + +RLK NEIL GIK+LK
Sbjct: 448 LYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKL 507
Query: 515 FAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNIL 574
+AWE F V+ R KEL +L F+ + IF+ P+ + TF + NN+
Sbjct: 508 YAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLK 567
Query: 575 DAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIR---HDC 631
A+ AF S++LF+IL PL +L ++ ++A +S ++L ++L D++ + R
Sbjct: 568 PAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626
Query: 632 NFDKAMQFS----EASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGE 687
F+ + + F+W AT+ ++++ I GQL ++G VG GKSSL+ A+LGE
Sbjct: 627 PFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 685
Query: 688 MENVHGHITIKG-----------------TTAYVPQQSWIQNGTIKDNILFGTEFNEKRY 730
M+ + G + + AY Q+ W+ N T+++NI FG+ FN++RY
Sbjct: 686 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 745
Query: 731 QQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSA 790
+ V +AC+L PD+++LP GD EIGE+GINLSGGQ+QRI +ARA YQN +I LDDP SA
Sbjct: 746 KAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSA 805
Query: 791 VDAHVGKHIFNKVLGPNGLLK-----GKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSY 845
+D H+ H+ + G+LK +T +LVTH + +L D I+ + +G+++ +G+
Sbjct: 806 LDIHLSDHLMQE-----GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTL 860
Query: 846 SALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRR 905
+ K E ++ KT + E E + +A T+ R
Sbjct: 861 KDIQTKDVELYEHWKTLMNRQDQELEKDM----------------------EADQTTLER 898
Query: 906 ENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIET-----G 960
K+LR ++ +R + EDE+ + ++ + + + T
Sbjct: 899 -------------------KTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT 939
Query: 961 KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR 1020
K+ + YL + G F + +I + ++ + + WL+ WTS+ I N+ +
Sbjct: 940 KMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT-----GKA 994
Query: 1021 DMRVGVYG-ALGLAQGIFVFIAHFWSA--FGFVHASNILHKQLLNNILRAPMRFFDTTPT 1077
D V G ++ GIF+ + + G A N LH LLN I+ P+RFFDTTP
Sbjct: 995 DQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKN-LHHNLLNKIILGPIRFFDTTPL 1053
Query: 1078 GRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSV 1137
G I+NRF+ D + +D +P +L S L +S + MI ATPVF + ++PLG+ + +
Sbjct: 1054 GLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFI 1113
Query: 1138 QMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCV 1197
Q ++ S+ L+ LD T+ P+ HFSET GL IRAF H+ RF + DTN
Sbjct: 1114 QKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAY 1173
Query: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257
+NRWL +R + +G V +++ + + + VG L AL IT LNW+VR
Sbjct: 1174 LFLSAANRWLEVRTDYLGACIVLTASIASI--SGSSNSGLVGLGLLYALTITNYLNWVVR 1231
Query: 1258 MTSEIETNIVAVERITEYTKVENE--APWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL 1315
+++E + AV+++ + +E+E + + P WP +G+I+ ++ VRY L
Sbjct: 1232 NLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKP 1291
Query: 1316 VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLRE 1375
VL+ + I +K+G+ GRTG+GKSSL+ FR+++ G+I+IDG+DI+ + LH LR
Sbjct: 1292 VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRS 1351
Query: 1376 KLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
+L+II QDPILFSGS+R NLDP +D+ +W+ALE+A LK+ V SL GL VTE G
Sbjct: 1352 RLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGE 1411
Query: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
N S+GQRQL CL RA +RKS IL++DEATA++D+ T+N++Q + FA TV+TIAHR+
Sbjct: 1412 NFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1471
Query: 1496 HTIMDSDKVMVLDNGKIIECGSPEELL 1522
+IMD+ V+V G ++EC + LL
Sbjct: 1472 SSIMDAGLVLVFSEGILVECDTVPNLL 1498
Score = 75.9 bits (185), Expect = 3e-13
Identities = 140/671 (20%), Positives = 274/671 (40%), Gaps = 68/671 (10%)
Query: 222 TLEDVWEVDEEMKT--KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKN 279
TL+D+ D E+ KTL+++ + ++++++ + L+R+ + + + A K
Sbjct: 859 TLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREA------KA 912
Query: 280 QSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVS 339
Q + +D E+ E+++ + V + K +KT + L L+ IF+
Sbjct: 913 QMEDED----EEEEEEEDEDDNMSTVMRL-RTKMPWKTCWRYLTSGGFFLLILMIFS--- 964
Query: 340 PQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMAS 399
+LLK + A D W + T Q++ + + LC G + ++ S
Sbjct: 965 -KLLKHSVIVAIDYWLATWTSEYS--INNTGKADQTYYVAGFSILC---GAGIFLCLVTS 1018
Query: 400 VYKKALTLS-------NLARK----------EYTVGETVNLMSVDAQKL-MDVTNFMHML 441
+ + + L+ NL K +G +N S D + + + L
Sbjct: 1019 LTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1078
Query: 442 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI 501
S L + +I + ++A + + V I SK +Q + + L
Sbjct: 1079 TRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH 1138
Query: 502 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
+E G+ ++ F E F+ ++ L N +A+ L ++ T L + +
Sbjct: 1139 FSETAEGLTTIRAFRHETRFKQRMLELTDT---NNIAYLFLSAANRWLEVRTDYLGACIV 1195
Query: 562 FSVYVLV---DSNNILDAQKAFTSITLFNILRFP---LSMLPMMISSMLQA-SVSTERLE 614
+ + SN+ L ++T+ N L + L+ L + + ++ + S T E
Sbjct: 1196 LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1255
Query: 615 KYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVG 674
Y G +D S + + ++ + +E++ + ++ V I GQ V + G G
Sbjct: 1256 NYEG--TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1313
Query: 675 SGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILF 721
SGKSSL A ++ G I I G + + Q + +G+I+ N+
Sbjct: 1314 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1373
Query: 722 GTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDI 781
+ + R + LE L ++ LPGG A + E G N S GQ+Q LARA + I
Sbjct: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
Query: 782 YLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVE 841
++D+ +++D ++I KV+ +T + + H + + ++V G +VE
Sbjct: 1434 LIMDEATASIDM-ATENILQKVV--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVE 1490
Query: 842 KGSYSALLAKK 852
+ LLA K
Sbjct: 1491 CDTVPNLLAHK 1501
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 724 bits (1869), Expect = 0.0
Identities = 465/1503 (30%), Positives = 755/1503 (50%), Gaps = 217/1503 (14%)
Query: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFS------AFS 185
L L+W+++ + T + ++ L N + + I G + + I F
Sbjct: 137 LFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFF 196
Query: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
N + P + + LS TY W +++I+ +K+P+ L+ + ++ M+
Sbjct: 197 MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMR 256
Query: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDV-- 292
T + + L+D
Sbjct: 257 AVT-----------------------------------------------NYVCLKDAYE 269
Query: 293 EKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASD 352
E+KKK + P WL A+++ F +L S + + D+ F P + ++ ++
Sbjct: 270 EQKKKVADHPNRTPSIWL--AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327
Query: 353 RDT----------------YLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAI 396
+L Y+ A+LLF A ++Q LQ + + + G+ +R A+
Sbjct: 328 TQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGAL 387
Query: 397 MASVYKKALTLS--NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFF 454
+A +Y K L LS NL+ E T+G+ NL++++ +LM LW+ +QI++ +
Sbjct: 388 LAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVIL 447
Query: 455 LWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKY 514
L+ LG S L G V+VL+ PI ++TK Q + +RLK NEIL GIK+LK
Sbjct: 448 LYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKL 507
Query: 515 FAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNIL 574
+AWE F V+ R KEL +L F+ + IF+ P+ + TF + NN+
Sbjct: 508 YAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLK 567
Query: 575 DAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDL------------ 622
A+ AF S++LF+IL PL +L ++ ++A +S ++L ++L D++
Sbjct: 568 PAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626
Query: 623 -------------------------------DTSAIRHDCNFDKAMQFSEASFTWEHDSE 651
T +R D A++ + F+W
Sbjct: 627 PFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWG-SGL 685
Query: 652 ATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG------------ 699
AT+ ++++ I GQL ++G VG GKSSL+ A+LGEM+ + G +
Sbjct: 686 ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATR 745
Query: 700 -----TTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEI 754
+ AY Q+ W+ N T+++NI FG+ FN++RY+ V +AC+L PD+++LP GD EI
Sbjct: 746 SRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
Query: 755 GEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLK--- 811
GE+GINLSGGQ+QRI +ARA YQN +I LDDP SA+D H+ H+ + G+LK
Sbjct: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE-----GILKFLQ 860
Query: 812 --GKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPE 869
+T +LVTH + +L D I+ + +G+++ +G+ + K E ++ KT + E
Sbjct: 861 DDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQE 920
Query: 870 EEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRN 929
E + +A T+ R K+LR
Sbjct: 921 LEKDM----------------------EADQTTLER-------------------KTLRR 939
Query: 930 SLKTRNVNSLKEDEELVKGQKLIKKEFIET-----GKVKFSIYLEYLQAIGLFSIFFIIL 984
++ +R + EDE+ + ++ + + + T K+ + YL + G F + +I
Sbjct: 940 AMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIF 999
Query: 985 AFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG-ALGLAQGIFVFIAHF 1043
+ ++ + + WL+ WTS+ I N+ + D V G ++ GIF+ +
Sbjct: 1000 SKLLKHSVIVAIDYWLATWTSEYSINNT-----GKADQTYYVAGFSILCGAGIFLCLVTS 1054
Query: 1044 WSA--FGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRS 1101
+ G A N LH LLN I+ P+RFFDTTP G I+NRF+ D + +D +P +L S
Sbjct: 1055 LTVEWMGLTAAKN-LHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLES 1113
Query: 1102 WITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYS 1161
L +S + MI ATPVF + ++PLG+ + +Q ++ S+ L+ LD T+ P+
Sbjct: 1114 LTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLC 1173
Query: 1162 HFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFF 1221
HFSET GL IRAF H+ RF + DTN +NRWL +R + +G V
Sbjct: 1174 HFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLT 1233
Query: 1222 SALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
+++ + + + VG L AL IT LNW+VR +++E + AV+++ + +E+E
Sbjct: 1234 ASIASI--SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
Query: 1282 --APWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
+ + P WP +G+I+ ++ VRY L VL+ + I +K+G+ GRTG+G
Sbjct: 1292 NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSG 1351
Query: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN 1399
KSSL+ FR+++ G+I+IDG+DI+ + LH LR +L+II QDPILFSGS+R NLDP
Sbjct: 1352 KSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPEC 1411
Query: 1400 NYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILV 1459
+D+ +W+ALE+A LK+ V SL GL VTE G N S+GQRQL CL RA +RKS IL+
Sbjct: 1412 KCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILI 1471
Query: 1460 LDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPE 1519
+DEATA++D+ T+N++Q + FA TV+TIAHR+HTI+ +D V+V+ G I+E +PE
Sbjct: 1472 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPE 1531
Query: 1520 ELL 1522
LL
Sbjct: 1532 SLL 1534
Score = 83.2 bits (204), Expect = 2e-15
Identities = 144/676 (21%), Positives = 282/676 (41%), Gaps = 69/676 (10%)
Query: 222 TLEDVWEVDEEMKT--KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKN 279
TL+D+ D E+ KTL+++ + ++++++ + L+R+ + + + A K
Sbjct: 895 TLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREA------KA 948
Query: 280 QSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVS 339
Q + +D E+ E+++ + V + K +KT + L L+ IF+
Sbjct: 949 QMEDED----EEEEEEEDEDDNMSTVMRL-RTKMPWKTCWRYLTSGGFFLLILMIFS--- 1000
Query: 340 PQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMAS 399
+LLK + A D W + T Q++ + + LC G + ++ S
Sbjct: 1001 -KLLKHSVIVAIDYWLATWTSEYS--INNTGKADQTYYVAGFSILC---GAGIFLCLVTS 1054
Query: 400 VYKKALTLS-------NLARK----------EYTVGETVNLMSVDAQKL-MDVTNFMHML 441
+ + + L+ NL K +G +N S D + + + L
Sbjct: 1055 LTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1114
Query: 442 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI 501
S L + +I + ++A + + V I SK +Q + + L
Sbjct: 1115 TRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH 1174
Query: 502 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
+E G+ ++ F E F+ ++ L N +A+ L ++ T L + +
Sbjct: 1175 FSETAEGLTTIRAFRHETRFKQRMLELTDT---NNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 562 FSVYVLV---DSNNILDAQKAFTSITLFNILRFP---LSMLPMMISSMLQA-SVSTERLE 614
+ + SN+ L ++T+ N L + L+ L + + ++ + S T E
Sbjct: 1232 LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
Query: 615 KYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVG 674
Y G +D S + + ++ + +E++ + ++ V I GQ V + G G
Sbjct: 1292 NYEG--TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
Query: 675 SGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILF 721
SGKSSL A ++ G I I G + + Q + +G+I+ N+
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
Query: 722 GTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDI 781
+ + R + LE L ++ LPGG A + E G N S GQ+Q LARA + I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
Query: 782 YLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVE 841
++D+ +++D ++I KV+ +T + + H +H + D ++V+ G I+E
Sbjct: 1470 LIMDEATASIDM-ATENILQKVV--MTAFADRTVVTIAHRVHTILTADLVIVMKRGNILE 1526
Query: 842 KGSYSALLAKK-GEFA 856
+ +LLA++ G FA
Sbjct: 1527 YDTPESLLAQENGVFA 1542
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 717 bits (1851), Expect = 0.0
Identities = 462/1503 (30%), Positives = 752/1503 (50%), Gaps = 217/1503 (14%)
Query: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFS------AFS 185
L L+W+++ + T + ++ L N + + I G + + I F
Sbjct: 137 LFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFF 196
Query: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
N + P + + LS TY W +++I+ +K+P+ L+ + ++ M+
Sbjct: 197 MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMR 256
Query: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDV-- 292
T + + L+D
Sbjct: 257 AVT-----------------------------------------------NYVCLKDAYE 269
Query: 293 EKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASD 352
E+KKK + P WL A+++ F +L S + + D+ F P + ++ ++
Sbjct: 270 EQKKKVADHPNRTPSIWL--AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327
Query: 353 RDT----------------YLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAI 396
+L Y+ A+LLF A ++Q LQ + + + G+ +R A+
Sbjct: 328 TQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGAL 387
Query: 397 MASVYKKALTLS--NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFF 454
+A +Y K L LS NL+ E T+G+ NL++++ +LM LW+ +QI++ +
Sbjct: 388 LAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVIL 447
Query: 455 LWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKY 514
L+ LG S L G V+VL+ PI ++TK Q + +RLK NEIL GIK+LK
Sbjct: 448 LYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKL 507
Query: 515 FAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNIL 574
+AWE F V+ R KEL +L F+ + IF+ P+ + TF + NN+
Sbjct: 508 YAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLK 567
Query: 575 DAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDL------------ 622
A+ AF S++LF+IL PL +L ++ ++A +S ++L ++L D++
Sbjct: 568 PAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626
Query: 623 -------------------------------DTSAIRHDCNFDKAMQFSEASFTWEHDSE 651
T +R D A++ + F+W
Sbjct: 627 PFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWG-SGL 685
Query: 652 ATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG------------ 699
AT+ ++++ I GQL ++G VG GKSSL+ A+LGEM+ + G +
Sbjct: 686 ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATR 745
Query: 700 -----TTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEI 754
+ AY Q+ W+ N T+++NI FG+ FN++RY+ V +AC+L PD+++LP GD EI
Sbjct: 746 SRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
Query: 755 GEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLK--- 811
GE+GINLSGGQ+QRI +ARA YQN +I LDDP SA+D H+ H+ + G+LK
Sbjct: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE-----GILKFLQ 860
Query: 812 --GKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPE 869
+T +LVTH + +L D I+ + +G+++ +G+ + K E ++ KT + E
Sbjct: 861 DDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQE 920
Query: 870 EEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRN 929
E + +A T+ R K+LR
Sbjct: 921 LEKDM----------------------EADQTTLER-------------------KTLRR 939
Query: 930 SLKTRNVNSLKEDEELVKGQKLIKKEFIET-----GKVKFSIYLEYLQAIGLFSIFFIIL 984
++ +R + EDE+ + ++ + + + T K+ + YL + G F + +I
Sbjct: 940 AMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIF 999
Query: 985 AFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG-ALGLAQGIFVFIAHF 1043
+ ++ + + WL+ WTS+ I N+ + D V G ++ GIF+ +
Sbjct: 1000 SKLLKHSVIVAIDYWLATWTSEYSINNT-----GKADQTYYVAGFSILCGAGIFLCLVTS 1054
Query: 1044 WSA--FGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRS 1101
+ G A N LH LLN I+ P+RFFDTTP G I+NRF+ D + +D +P +L S
Sbjct: 1055 LTVEWMGLTAAKN-LHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLES 1113
Query: 1102 WITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYS 1161
L +S + MI ATPVF + ++PLG+ + +Q ++ S+ L+ LD T+ P+
Sbjct: 1114 LTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLC 1173
Query: 1162 HFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFF 1221
HFSET GL IRAF H+ RF + DTN +NRWL +R + +G V
Sbjct: 1174 HFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLT 1233
Query: 1222 SALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
+++ + + + VG L AL IT LNW+VR +++E + AV+++ + +E+E
Sbjct: 1234 ASIASI--SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
Query: 1282 --APWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
+ + P WP +G+I+ ++ VRY L VL+ + I +K+G+ GRTG+G
Sbjct: 1292 NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSG 1351
Query: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN 1399
KSSL+ FR+++ G+I+IDG+DI+ + LH LR +L+II QDPILFSGS+R NLDP
Sbjct: 1352 KSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPEC 1411
Query: 1400 NYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILV 1459
+D+ +W+ALE+A LK+ V SL GL VTE G N S+GQRQL CL RA +RKS IL+
Sbjct: 1412 KCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILI 1471
Query: 1460 LDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPE 1519
+DEATA++D+ T+N++Q + FA TV+TIAHR+ +IMD+ V+V G ++EC +
Sbjct: 1472 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVP 1531
Query: 1520 ELL 1522
LL
Sbjct: 1532 NLL 1534
Score = 75.9 bits (185), Expect = 3e-13
Identities = 140/671 (20%), Positives = 274/671 (40%), Gaps = 68/671 (10%)
Query: 222 TLEDVWEVDEEMKT--KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKN 279
TL+D+ D E+ KTL+++ + ++++++ + L+R+ + + + A K
Sbjct: 895 TLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREA------KA 948
Query: 280 QSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVS 339
Q + +D E+ E+++ + V + K +KT + L L+ IF+
Sbjct: 949 QMEDED----EEEEEEEDEDDNMSTVMRL-RTKMPWKTCWRYLTSGGFFLLILMIFS--- 1000
Query: 340 PQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMAS 399
+LLK + A D W + T Q++ + + LC G + ++ S
Sbjct: 1001 -KLLKHSVIVAIDYWLATWTSEYS--INNTGKADQTYYVAGFSILC---GAGIFLCLVTS 1054
Query: 400 VYKKALTLS-------NLARK----------EYTVGETVNLMSVDAQKL-MDVTNFMHML 441
+ + + L+ NL K +G +N S D + + + L
Sbjct: 1055 LTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1114
Query: 442 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI 501
S L + +I + ++A + + V I SK +Q + + L
Sbjct: 1115 TRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH 1174
Query: 502 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
+E G+ ++ F E F+ ++ L N +A+ L ++ T L + +
Sbjct: 1175 FSETAEGLTTIRAFRHETRFKQRMLELTDT---NNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 562 FSVYVLV---DSNNILDAQKAFTSITLFNILRFP---LSMLPMMISSMLQA-SVSTERLE 614
+ + SN+ L ++T+ N L + L+ L + + ++ + S T E
Sbjct: 1232 LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
Query: 615 KYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVG 674
Y G +D S + + ++ + +E++ + ++ V I GQ V + G G
Sbjct: 1292 NYEG--TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
Query: 675 SGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILF 721
SGKSSL A ++ G I I G + + Q + +G+I+ N+
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
Query: 722 GTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDI 781
+ + R + LE L ++ LPGG A + E G N S GQ+Q LARA + I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
Query: 782 YLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVE 841
++D+ +++D ++I KV+ +T + + H + + ++V G +VE
Sbjct: 1470 LIMDEATASIDM-ATENILQKVV--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVE 1526
Query: 842 KGSYSALLAKK 852
+ LLA K
Sbjct: 1527 CDTVPNLLAHK 1537
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 717 bits (1850), Expect = 0.0
Identities = 381/728 (52%), Positives = 510/728 (70%), Gaps = 20/728 (2%)
Query: 813 KTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA 872
KTR+LVTHSM +LPQVD I+V+ G I E GSY LLA+ G FA+ L+T+ T E++A
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA 763
Query: 873 TVHDGSEEEDDDYGLISSVEEIP--EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNS 930
EE+ G+ +E E+ +T +R LS SS +G + ++
Sbjct: 764 -------EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNST 816
Query: 931 LKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNS 990
+ + + KE+ KL++ + +TG+VK S+Y +Y++AIGLF F I F+ N
Sbjct: 817 AELQKAEAKKEET-----WKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNH 871
Query: 991 VAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFV 1050
V+ + SN WLS WT D I N T +R+ VYGALG++QGI VF + G +
Sbjct: 872 VSALASNYWLSLWTDDP-IVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGI 927
Query: 1051 HASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII 1110
AS LH LL++ILR+PM FF+ TP+G +VNRF+ ++ TVD +P+ ++ ++ +I
Sbjct: 928 LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI 987
Query: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
++I +ATP+ II+ PLG+IY VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+
Sbjct: 988 GACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1047
Query: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYR 1230
VIRAFE Q+RF+ +++++D NQK + I +NRWLA+RLE VGN V F+AL VI R
Sbjct: 1048 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
Query: 1231 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKR 1289
+LS VG +S +L +T LNWLVRM+SE+ETNIVAVER+ EY++ E EAPW + +
Sbjct: 1108 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1167
Query: 1290 PPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFR 1349
PP WP G+++F NY +RYR +LD VLR I I EK+G+VGRTGAGKSSLT LFR
Sbjct: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
Query: 1350 ILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA 1409
I E+A G+IIIDG++IA IGLHDLR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +
Sbjct: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
Query: 1410 LELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL 1469
LELAHLK FV++L L HE E G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDL
Sbjct: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
Query: 1470 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
ETD+LIQ+TI+ +F CTV+TIAHRL+TIMD +V+VLD G+I E G+P +LLQ G FY
Sbjct: 1348 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1407
Query: 1530 FMAKEAGI 1537
MAK+AG+
Sbjct: 1408 SMAKDAGL 1415
Score = 486 bits (1251), Expect = e-137
Identities = 280/717 (39%), Positives = 427/717 (59%), Gaps = 40/717 (5%)
Query: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
Query: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
Query: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
Query: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
Query: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
Query: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
Query: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
Query: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
Query: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIK------GTTAYVPQ 706
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IK + +Y+PQ
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
Score = 92.4 bits (228), Expect = 3e-18
Identities = 94/375 (25%), Positives = 159/375 (42%), Gaps = 31/375 (8%)
Query: 503 NEILSGIKILKYFAWEPSFRDQ----VQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVS 558
NE L G+ +++ F + F Q V +K +++A L +L V
Sbjct: 1041 NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL------AVRLECVGNC 1094
Query: 559 VVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLG 618
+V F+ V S + L A S++ + L+ L M S M V+ ERL++Y
Sbjct: 1095 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1154
Query: 619 GDDLDTSAIRHDCNFDKAMQFSEASFT-----WEHDSEATVRDVNLDIMAGQLVAVIGPV 673
+ I+ Q F + D + +R +N+ I G+ V ++G
Sbjct: 1155 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1214
Query: 674 GSGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNIL 720
G+GKSSL + E+ G I I G +PQ + +G+++ N+
Sbjct: 1215 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1274
Query: 721 FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD 780
++++++ LE L + LP E E G NLS GQ+Q + LARA +
Sbjct: 1275 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
Query: 781 IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV 840
I +LD+ +AVD I + + + T L + H ++ + ++VL G I
Sbjct: 1335 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1391
Query: 841 EKGSYSALLAKKGEF 855
E G+ S LL ++G F
Sbjct: 1392 EYGAPSDLLQQRGLF 1406
Score = 46.6 bits (109), Expect = 2e-04
Identities = 60/294 (20%), Positives = 115/294 (39%), Gaps = 13/294 (4%)
Query: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
++ G IVN + D D W + L +I L ++ + + + + ++
Sbjct: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIW-SAPLQVILALYLLWLNLGPSVLAGVAVMVL 475
Query: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIR------AFEHQQRFLKHNE 1187
V V ++ + ++ +E ++G+ V++ AF+ + ++ E
Sbjct: 476 MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
Query: 1188 VRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALN 1247
+++ + S + + W+ LV T A+ + I + + FV N
Sbjct: 536 LKV-LKKSAYLSAVGTFTWVCTPF-LVALCTF---AVYVTIDENNILDAQTAFVSLALFN 590
Query: 1248 ITQ-TLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQ 1306
I + LN L + S I V+++R+ + E P ++RP D I N
Sbjct: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
Query: 1307 VRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
+ L GIT I + VVG+ G GKSSL + L ++ G + I
Sbjct: 651 FTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 32.7 bits (73), Expect = 2.8
Identities = 17/50 (34%), Positives = 26/50 (52%)
Query: 1479 IQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPF 1528
++ A T I + H + + D ++V+ GKI E GS +ELL G F
Sbjct: 698 VEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 747
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 709 bits (1831), Expect = 0.0
Identities = 468/1504 (31%), Positives = 750/1504 (49%), Gaps = 189/1504 (12%)
Query: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSA------FS 185
L ++W L+ + T +F + + + L I YG +L+ + F
Sbjct: 139 LLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFF 198
Query: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
+ P + + LS TY W ++ I +K+P+ L + ++ M+
Sbjct: 199 KTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMR 258
Query: 235 TKT----LVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLE 290
T L F+ +++++Q + A R ++ G RL S +L
Sbjct: 259 ALTNYQRLCEAFDAQVRKDIQGTQGA--RAIWQALSHAFGRRLV-------LSSTFRILA 309
Query: 291 DVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFA 350
D+ G + ++ L K ND+F P+ L + F
Sbjct: 310 DL------LGFAGPLCIFGIVDHLGKE--------------NDVF---QPKTQFLGVYFV 346
Query: 351 SDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLS-- 408
S ++ +L Y+ A+LLF A L+Q LQ + + + G+ +R AI +Y K + LS
Sbjct: 347 SSQE-FLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405
Query: 409 NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVG 468
NL+ E T G+ NL+++D +LM LW+ +QI++ + L+ LG S L G
Sbjct: 406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAA 465
Query: 469 VMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNL 528
V++L+ P+ ++TK Q ++ ++RLK NE+L GIK+LK +AWE FR +V+
Sbjct: 466 VIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETT 525
Query: 529 RKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNI 588
R+KE+ +L AF+ + IF+ P+ ++TF +V AF S++LF+I
Sbjct: 526 RRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHI 585
Query: 589 LRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAI--------------------- 627
L PL +L ++ S ++A VS ++L ++L ++
Sbjct: 586 LVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRV 645
Query: 628 -------RHDCNF-----------------DKAMQFSEASFTWEHDSEATVRDVNLDIMA 663
R DC + +Q FTW D T+ ++ + I
Sbjct: 646 VNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPR 705
Query: 664 GQLVAVIGPVGSGKSSLISAMLGEMENVHG--------------------------HITI 697
GQL ++G VG GKSSL+ A LGEM+ V G I
Sbjct: 706 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRK 765
Query: 698 KGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEK 757
+G AY Q+ W+ N T+++NI+F + FN++RY+ V+EAC+L PD+++LP GD +IGE+
Sbjct: 766 RGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGER 825
Query: 758 GINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKG--KTR 815
GINLSGGQ+QRIS+ARA YQ+ ++ LDDP SA+D H+ H+ G LL+ +T
Sbjct: 826 GINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA--GILELLRDDKRTV 883
Query: 816 LLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVH 875
+LVTH + +LP D I+ + +GTI +G+ + + ++ KT + E E
Sbjct: 884 VLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKE-- 941
Query: 876 DGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRN 935
++T R+ + LSR+ S L+
Sbjct: 942 ------------------------TVTERKATEPPQGLSRAMSSRDGLLQ---------- 967
Query: 936 VNSLKEDEELVKGQK--LIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAF 993
+ +E+EE + ++ + + ++ + +YL + G+ + ++ + ++ +
Sbjct: 968 -DEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVL 1026
Query: 994 IGSNLWLSAWTSDSKIFNSTDYPASQRD----------MRVGVYGALGLAQGIFVFIAHF 1043
+ + WL+ WT + S M V +LG+ + +
Sbjct: 1027 VAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVE 1086
Query: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
W+ + + LH+ LLN I+ APMRFF+TTP G I+NRF+ D +T+D +P +L
Sbjct: 1087 WTG---LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
Query: 1104 TCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHF 1163
L +S L +I TPVF + ++PL I+ +Q ++ SR L++LD T+ P+ SHF
Sbjct: 1144 RSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF 1203
Query: 1164 SETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSA 1223
+ETV GL IRAF ++ RF + D+N +NRWL +R+E +G V +A
Sbjct: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
Query: 1224 LMMV---IYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN 1280
+ + ++R+ LS VG L+ AL ++ LNW+VR +++E + AV+RI K E
Sbjct: 1264 VTSISNSLHRE-LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEA 1322
Query: 1281 EA--PWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGA 1338
E+ + P +WP +GKIQ N VRY L VL+ + I +KIG+ GRTG+
Sbjct: 1323 ESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGS 1382
Query: 1339 GKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPF 1398
GKSS + FR+++ G IIIDG+DIA + LH LR +L+II QDP+LFSG++R NLDP
Sbjct: 1383 GKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPE 1442
Query: 1399 NNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKIL 1458
SD +W+ALE+A LK V +L GL +TE G N S GQRQL CL RA +RK+ I
Sbjct: 1443 RKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF 1502
Query: 1459 VLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSP 1518
++DEATA++D+ T+N++Q + FA TV+TIAHR+HTI+ +D V+VL G I+E P
Sbjct: 1503 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKP 1562
Query: 1519 EELL 1522
E+LL
Sbjct: 1563 EKLL 1566
Score = 87.0 bits (214), Expect = 1e-16
Identities = 139/664 (20%), Positives = 262/664 (39%), Gaps = 69/664 (10%)
Query: 236 KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKK 295
KTL+++ + +++E R+A + Q S +S L L + + ++A E+ +
Sbjct: 928 KTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGL--LQDEEEEEEEAAESEEDDNL 985
Query: 296 KKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDT 355
+ ++P W A + + +LL S L V QLLK ++ A D
Sbjct: 986 SSMLHQRAEIP--WRACAKYLSSAGILLLSLL----------VFSQLLKHMVLVAIDYWL 1033
Query: 356 YLWIGYLCAILLFTAALIQSFCLQCYFQ-----------------LCFKL-------GVK 391
W A+ L AA S +C LC G+K
Sbjct: 1034 AKWTD--SALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLK 1091
Query: 392 VRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL-MDVTNFMHMLWSSVLQIVL 450
V + S+ + + + +G +N S D + + + + L S L V
Sbjct: 1092 VAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVS 1151
Query: 451 SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIK 510
++ + ++A + + ++ I S+ +Q + + L E + G+
Sbjct: 1152 ALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLT 1211
Query: 511 ILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDS 570
++ F +E F+ Q L + N +A L ++ + + V V S
Sbjct: 1212 TIRAFRYEARFQ---QKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSIS 1268
Query: 571 NNI---LDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD------ 621
N++ L A +T ++ L+ + ++ M + +R+ L +
Sbjct: 1269 NSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGL 1328
Query: 622 LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLI 681
L S I + +Q S ++ + ++ VN I GQ + + G GSGKSS
Sbjct: 1329 LAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFS 1388
Query: 682 SAMLGEMENVHGHI-------------TIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEK 728
A ++ GHI T++ + + Q + +GTI+ N+ + ++
Sbjct: 1389 LAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDS 1448
Query: 729 RYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPL 788
+ LE L ++ LPGG A I E G N S GQ+Q LARA + I+++D+
Sbjct: 1449 TLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEAT 1508
Query: 789 SAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSAL 848
+++D ++I KV+ +T + + H +H + D ++VL G I+E L
Sbjct: 1509 ASIDM-ATENILQKVV--MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKL 1565
Query: 849 LAKK 852
L++K
Sbjct: 1566 LSRK 1569
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 702 bits (1811), Expect = 0.0
Identities = 429/1278 (33%), Positives = 693/1278 (54%), Gaps = 127/1278 (9%)
Query: 310 LMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFT 369
L +AL+ F L LLKLV + F P LL LL+ F + L G L A+ L
Sbjct: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAG 289
Query: 370 AALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQ 429
A++ + Y +K+ ++ R A++ +Y KAL L GE +NL+ D++
Sbjct: 290 GAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKAL---QLGPSRPPTGEALNLLGTDSE 346
Query: 430 KLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQV 489
+L++ H W LQ+ ++++ L++++G + + G+ + +L++P+N +++T+
Sbjct: 347 RLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQ 406
Query: 490 KNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFV 549
+ +++KD R+K++ E+LSGI+++K+ WE + +V+ R +EL L L +++
Sbjct: 407 EMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYL 466
Query: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVS 609
+ PV++S+V F YVL+ L A K FT++ L +L PL+ P +I+ +L+A VS
Sbjct: 467 WAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVINGLLEAKVS 524
Query: 610 TERLEKYLGGDDLDTSAIRH-DCNF-----------------DKAMQFSEASFTWEHDSE 651
+R++ +L + + A DC ++ A F+W+
Sbjct: 525 LDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGT 584
Query: 652 ATVRDVN-LDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT---AYVPQQ 707
+ ++ L++ G LV ++G VG GKSSL++A+ GE+ + GH+ ++G + Q+
Sbjct: 585 SLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQE 644
Query: 708 SWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQ 767
WIQ TI+DNILFG F+ + Y++VLEACAL DL +LP GD E+GEKG+ LSGGQ+
Sbjct: 645 PWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRA 704
Query: 768 RISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQ 827
RI+LARA YQ ++YLLDDPL+AVDA V H+ ++ + G+L TRLL TH +L +
Sbjct: 705 RIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTRLLCTHRTEYLER 762
Query: 828 VDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGL 887
D ++++ G ++ G S +L
Sbjct: 763 ADAVLLMEAGRLIRAGPPSEILPL------------------------------------ 786
Query: 888 ISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVK 947
V+ +P+ A S+ +S++N KT+ E+E+
Sbjct: 787 ---VQAVPKAWAE--------------NGQESDSATAQSVQNPEKTKEG---LEEEQSTS 826
Query: 948 GQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDS 1007
G +L+++E + G V +Y Y +A+G I+ + ++ ++ WLS W S
Sbjct: 827 G-RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQL 885
Query: 1008 KIFNSTDY------------------------------------PASQRDMR--VGVYGA 1029
K NS+ P D+R + VY
Sbjct: 886 KAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYAT 945
Query: 1030 LGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDIS 1089
+ + + A G + A+ LH++LL+ +L AP+ FF+ TPTGRI+NRF+ D++
Sbjct: 946 IAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVA 1005
Query: 1090 TVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLR 1149
DD+LP L + G++ L ++ P +++ PL I+Y VQ Y ++SR+LR
Sbjct: 1006 CADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELR 1065
Query: 1150 RLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAI 1209
RL S+T SP+YSH ++T++GL V+RA RF + N ++ NQ+C F+ + +WL I
Sbjct: 1066 RLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDI 1125
Query: 1210 RLELVGNLTV-FFSALMMVIYRDTLSG-DTVGFVLSNALNITQTLNWLVRMTSEIETNIV 1267
RL+L+G V + + +V ++ L+ VG LS AL++T L+ LV ++ E +V
Sbjct: 1126 RLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLV 1185
Query: 1268 AVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSM 1327
+VER+ EYT + P + W ++G ++F + + YRP L L G+T +
Sbjct: 1186 SVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPG 1245
Query: 1328 EKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILF 1387
EK+G+VGRTG+GKSSL LFR+LE + G++++DGVD + + L LR +L IIPQ+P LF
Sbjct: 1246 EKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLF 1305
Query: 1388 SGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCL 1447
SG++R NLDP + D +W+AL+ HL + S+ GL E+ E G +LS+GQRQLLCL
Sbjct: 1306 SGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLGQRQLLCL 1364
Query: 1448 GRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVL 1507
RALL +KIL +DEATA+VD +TD L+Q TI FA+ TV+TIAHRL+TI++SD+V+VL
Sbjct: 1365 ARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVL 1424
Query: 1508 DNGKIIECGSPEELLQIP 1525
G+++E SP L P
Sbjct: 1425 QAGRVVELDSPATLRNQP 1442
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 697 bits (1799), Expect = 0.0
Identities = 447/1416 (31%), Positives = 736/1416 (51%), Gaps = 173/1416 (12%)
Query: 193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252
NP A LS T+SW +++KGY++ LT++ + + + T +F E+ +
Sbjct: 44 NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR 103
Query: 253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
EK+S L
Sbjct: 104 VG------PEKAS--------------------------------------------LSH 113
Query: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDT-YLWIGYLCAILLFTAA 371
++K +L + ++ I + P +L I ++R + +W+G I LF
Sbjct: 114 VVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATE 173
Query: 372 LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL 431
+ F + + ++ ++++ A+ V++ ++ L +VGE +N++S D+ L
Sbjct: 174 FTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSL 231
Query: 432 MDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKN 491
+ F + + + +V + + LGP+ L G+ V V+ IP+ ++ + +
Sbjct: 232 FEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSA 291
Query: 492 MKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQ 551
+ DKR++ MNE L+ I+++K +AWE SF + +Q++R++E K L +Q +
Sbjct: 292 ILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAP 351
Query: 552 LTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTE 611
+ + V+T S ++L+ L A AF+ I +FN+++F +++LP I +M +A+VS
Sbjct: 352 IVSTIAIVLTLSCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLR 409
Query: 612 RLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDS--------------------- 650
R++K L D S I + D + + A+ TWEH++
Sbjct: 410 RMKKILI-DKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQR 468
Query: 651 ------------------------EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLG 686
++ + ++ + G+++ + G VGSGKSSL++A+LG
Sbjct: 469 SEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLG 528
Query: 687 EMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEML 746
+M+ G + + GT AYV QQ+WI +G +++NILFG +++ +RYQ + C L DL L
Sbjct: 529 QMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNL 588
Query: 747 PGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGP 806
P GDL EIGE+G+NLSGGQ+QRISLARA Y + +YLLDDPLSAVDAHVGKH+F + +
Sbjct: 589 PYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK 648
Query: 807 NGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTF--LR 864
L+GKT +LVTH + FL DE+++L +G I EKG++ L+ ++G +AK + L+
Sbjct: 649 T--LRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
Query: 865 HTGPEE--EATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGR 922
PE A + + +E S E EDA I + N + G+
Sbjct: 707 FKDPEHLYNAAMVEAFKE---------SPAEREEDAGIIVLAPGNE---------KDEGK 748
Query: 923 HLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIG--LFSIF 980
++ + T+ V +LI+ E + G V + Y Y++A G L S+F
Sbjct: 749 ESETGSEFVDTK-----------VPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
Query: 981 FIILAFVM-NSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDM-RVG---------VYGA 1029
+ L +M S AF SN WL W T P R M VG VY
Sbjct: 798 TVFLFLLMIGSAAF--SNWWLGLWLDKGS--RMTCGPQGNRTMCEVGAVLADIGQHVYQW 853
Query: 1030 LGLAQGIFVFIAHFWSAFGFVH----ASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
+ A +F+ + F F AS+ LH + + IL++PM FFDTTPTGR++NRF+
Sbjct: 854 VYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFS 913
Query: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
D+ +D LP +++ F ++ LV++ P ++V L + + + +
Sbjct: 914 KDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGV 973
Query: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNR 1205
++L+++++V+RSP ++H + ++ GL +I A+ ++ + ++ + + C R
Sbjct: 974 QELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFN----CAL------R 1023
Query: 1206 WLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETN 1265
W A+R++++ N+ F AL++ + ++S + G LS + ++ L VR +E +
Sbjct: 1024 WFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAK 1083
Query: 1266 IVAVERITEYTKVENEAPWVTDKRP----PPDWPSKGKIQFNNYQVRYRPELDLVLRGIT 1321
+VE + EY + P T P DWPS+G+I F +YQ+RYR LVL +
Sbjct: 1084 FTSVELLREY--ISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLN 1141
Query: 1322 CDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIP 1381
+I S + +G+VGRTG+GKSSL LFR++E A G I ID VDI + L DLR KLT+IP
Sbjct: 1142 LNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIP 1201
Query: 1382 QDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQ 1441
QDP+LF G++R NLDPF +++DE +W+ LE ++ + L L EVTE G N S+G+
Sbjct: 1202 QDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGE 1261
Query: 1442 RQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDS 1501
RQLLC+ RALLR SKI++LDEATA++D +TD L+Q TI++ F CTV+TIAHRL+T+++
Sbjct: 1262 RQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNC 1321
Query: 1502 DKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
D V+V++NGK+IE PE L + P + M A +
Sbjct: 1322 DHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEV 1357
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 653 bits (1685), Expect = 0.0
Identities = 388/917 (42%), Positives = 535/917 (58%), Gaps = 78/917 (8%)
Query: 651 EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWI 710
+ T+ ++L+I G+LV + G VGSGK+SLISA+LG+M + G I I GT AYV QQ+WI
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWI 634
Query: 711 QNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRIS 770
N T++DNILFG E++E+RY VL +C L PDL +LP DL EIGE+G NLSGGQ+QRIS
Sbjct: 635 LNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRIS 694
Query: 771 LARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDE 830
LARA Y + IY+LDDPLSA+DAHVG HIFN + + LK KT L VTH + +L DE
Sbjct: 695 LARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDE 752
Query: 831 IVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISS 890
++ + G I E+G++ L+ G++A L P E
Sbjct: 753 VIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVE------------------- 793
Query: 891 VEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQK 950
I ++E S G KS KT +V E+ VK ++
Sbjct: 794 ----------INSKKETS------------GSQKKSQDKGPKTGSVKK----EKAVKPEE 827
Query: 951 --LIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA-FVMNSVAFIGSNLWLSAW---- 1003
L++ E G V +S+Y Y+QA G F +I+A F++N + S WLS W
Sbjct: 828 GQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQG 887
Query: 1004 -------------TSDSKIFNS-TDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF 1049
SDS N Y AS + + V L +G+ VF+ G
Sbjct: 888 SGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGV-VFVK------GT 940
Query: 1050 VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGI 1109
+ AS+ LH +L ILR+PM+FFDTTPTGRI+NRF+ D+ VD LP +I + +
Sbjct: 941 LRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILV 1000
Query: 1110 ISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSG 1169
+ MI P F + V PL I++ + + R+L+RLD++T+SP SH + ++ G
Sbjct: 1001 FFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQG 1060
Query: 1170 LPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIY 1229
L I A+ Q FL + +D NQ F + + RWLA+RL+L+ + + LM+V+
Sbjct: 1061 LATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLM 1120
Query: 1230 RDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN-EAPW-VTD 1287
+ G +S A+ +T + VR+ SE E +VERI Y K + EAP + +
Sbjct: 1121 HGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKN 1180
Query: 1288 KRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCL 1347
K P PDWP +G++ F N ++RYR L LVL+ ++ I EKIG+VGRTG+GKSSL L
Sbjct: 1181 KAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMAL 1240
Query: 1348 FRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIW 1407
FR++E +GG I IDGV I+ IGL DLR KL+IIPQ+P+LFSG++R NLDPFN Y++++IW
Sbjct: 1241 FRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIW 1300
Query: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
ALE H+K +A L L L EV E G N S+G+RQLLC+ RALLR KIL+LDEATAA+
Sbjct: 1301 DALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAM 1360
Query: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
D ETD LIQ TI+ FA CT++TIAHRLHT++ SD++MVL G+++E +P LL
Sbjct: 1361 DTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSS 1420
Query: 1528 FYFMAKEAGIENVNSTK 1544
F A A EN + K
Sbjct: 1421 -RFYAMFAAAENKVAVK 1436
Score = 137 bits (346), Expect = 6e-32
Identities = 106/424 (25%), Positives = 194/424 (45%), Gaps = 56/424 (13%)
Query: 193 NPSSIASFLSSITYSWYDSIILKGYKR-PLTLEDVWEVDEEMKTKTLVSKFETHMKRELQ 251
+P A S +T+SW S+ +K+ L++EDVW + + + + E + EL
Sbjct: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
Query: 252 KARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLM 311
+ DA L V W
Sbjct: 159 EV-----------------------------GPDAASLRRV---------------VW-- 172
Query: 312 KALFKTFYMVLLKSFLLKLVNDIFTFVSPQ-LLKLLISFASDRDTYLWIGYLCAILLFTA 370
+F ++L S + ++ + F P ++K L+ + ++ L L + L
Sbjct: 173 --IFCRTRLIL--SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLT 228
Query: 371 ALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQK 430
+++S+ L + L ++ GV++R AI+ +KK L L N+ KE ++GE +N+ S D Q+
Sbjct: 229 EIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNI--KEKSLGELINICSNDGQR 286
Query: 431 LMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVK 490
+ + +L + +L + + LGP+ G V +L P S + + K
Sbjct: 287 MFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRK 346
Query: 491 NMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVF 550
+ D+R++ MNE+L+ IK +K +AW +F VQ +R++E + L Q + + V
Sbjct: 347 CVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVA 406
Query: 551 QLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVST 610
+ V+ SVVTFSV++ + + L A +AFT +T+FN + F L + P + S+ +ASV+
Sbjct: 407 PIVVVIASVVTFSVHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAV 464
Query: 611 ERLE 614
+R +
Sbjct: 465 DRFK 468
Score = 90.9 bits (224), Expect = 9e-18
Identities = 66/244 (27%), Positives = 109/244 (44%), Gaps = 20/244 (8%)
Query: 1286 TDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTN 1345
+D+RP P+ I + + L L I +I + +G+ G G+GK+SL +
Sbjct: 553 SDERPSPEEEEGKHIHLGHLR------LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS 606
Query: 1346 CLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEE 1405
+ + G I I G + Q + + +LR N+ Y +E
Sbjct: 607 AILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKEYDEER 653
Query: 1406 IWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATA 1465
L L+ +A L E+ E G NLS GQRQ + L RAL I +LD+ +
Sbjct: 654 YNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLS 713
Query: 1466 AVDLETDN-LIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQI 1524
A+D N + + I+ TV+ + H+L ++D D+V+ + G I E G+ EEL+ +
Sbjct: 714 ALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNL 773
Query: 1525 PGPF 1528
G +
Sbjct: 774 NGDY 777
Score = 80.5 bits (197), Expect = 1e-14
Identities = 95/434 (21%), Positives = 187/434 (43%), Gaps = 40/434 (9%)
Query: 446 LQIVLSIFFLWRELG---PSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKR---- 498
+Q V+ +FF + P L VG +V++ + I+S + ++ +K D
Sbjct: 994 IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR----VLIRELKRLDNITQSP 1049
Query: 499 -LKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFV-FQLTPVL 556
L + + G+ + + F + Q L N F C + ++ +L +
Sbjct: 1050 FLSHITSSIQGLATIHAYNKGQEFLHRYQELLDD---NQAPFFLFTCAMRWLAVRLDLIS 1106
Query: 557 VSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQAS-VSTERLEK 615
++++T + ++V + + A +I+ + + L + ++S +A S ER+
Sbjct: 1107 IALITTTGLMIVLMHGQIPPAYAGLAIS-YAVQLTGLFQFTVRLASETEARFTSVERINH 1165
Query: 616 YLGGDDLDTSA-IRH-----DCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAV 669
Y+ L+ A I++ D + + F A + + ++ V+ I + + +
Sbjct: 1166 YIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGI 1225
Query: 670 IGPVGSGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIK 716
+G GSGKSSL A+ +E G I I G + +PQ+ + +GT++
Sbjct: 1226 VGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVR 1285
Query: 717 DNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATY 776
N+ ++ E + LE + + LP +E+ E G N S G++Q + +ARA
Sbjct: 1286 SNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALL 1345
Query: 777 QNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGN 836
++ I +LD+ +A+D I + T L + H +H + D I+VL
Sbjct: 1346 RHCKILILDEATAAMDTETDLLIQETI---REAFADCTMLTIAHRLHTVLGSDRIMVLAQ 1402
Query: 837 GTIVEKGSYSALLA 850
G +VE + S LL+
Sbjct: 1403 GQVVEFDTPSVLLS 1416
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 646 bits (1667), Expect = 0.0
Identities = 407/1229 (33%), Positives = 648/1229 (52%), Gaps = 133/1229 (10%)
Query: 367 LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426
LF + ++S + + + ++ R A+ + ++K + ++ T GE ++ +
Sbjct: 209 LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266
Query: 427 DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486
D L + + ++ + +V+ + +G + + +LV P+ ++ +
Sbjct: 267 DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326
Query: 487 IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546
Q + D+R+++ +E+L+ IK++K + WE F +++LR+KE K L +Q +
Sbjct: 327 AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386
Query: 547 IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604
+T ++ V +V+VL+ ++ L A AF+ + N+LR + +P+ + +
Sbjct: 387 ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442
Query: 605 QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647
+ + R +K+ L S + + KA+ F EA+ +W+
Sbjct: 443 NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498
Query: 648 ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685
H SE R +NL + G ++ V G GSGKSSL+SA+L
Sbjct: 499 RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558
Query: 686 GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745
EM + G + ++G+ AYVPQQ+WI +G I++NIL G +++ RY QVL C+L DLE+
Sbjct: 559 EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805
LP GD+ EIGE+G+NLSGGQKQRISLARA Y + IYLLDDPLSAVDAHVGKHIF + +
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 806 PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865
L+GKT +LVTH + +L +I++L NG I E G++S L+ KKG++A+ ++
Sbjct: 679 KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733
Query: 866 TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925
+EAT ++ +D A I + + + +
Sbjct: 734 ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761
Query: 926 SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985
SL SL N N++ E + L ++E +E G + + +Y Y+QA G + + II
Sbjct: 762 SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811
Query: 986 FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030
FV+ V I S WLS W T+ S+ N T D P Q VYG
Sbjct: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869
Query: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082
L + GIF + AS LH +L N + R PM FFDT P GR++N
Sbjct: 870 ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142
FAGD+ +D LP ++ L +I+ L+++ + +P ++ + +I M +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202
+RL++ +RSP++SH ++ GL I + + F+ + D + +++
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262
S RW+A+RLE++ NL AL + + ++ L + + R+ E
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
E AVERI +Y K+ +EAP + P WP G+I F +Y ++YR VL GI
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
I E +G+VGRTG+GKSSL LFR++E G+I+IDGVDI SIGL DLR KL++I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
PQDP+L SG++R NLDPF+ ++D++IW ALE L ++ L +V E GGN S+G
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVG 1281
Query: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
+RQLLC+ RA+LR SKI+++DEATA++D+ETD LIQ TI+ F CTV+ IAHR+ T+++
Sbjct: 1282 ERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1341
Query: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
D ++V+ NGK++E PE L + PG +
Sbjct: 1342 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 646 bits (1667), Expect = 0.0
Identities = 407/1229 (33%), Positives = 648/1229 (52%), Gaps = 133/1229 (10%)
Query: 367 LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426
LF + ++S + + + ++ R A+ + ++K + ++ T GE ++ +
Sbjct: 209 LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266
Query: 427 DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486
D L + + ++ + +V+ + +G + + +LV P+ ++ +
Sbjct: 267 DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326
Query: 487 IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546
Q + D+R+++ +E+L+ IK++K + WE F +++LR+KE K L +Q +
Sbjct: 327 AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386
Query: 547 IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604
+T ++ V +V+VL+ ++ L A AF+ + N+LR + +P+ + +
Sbjct: 387 ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442
Query: 605 QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647
+ + R +K+ L S + + KA+ F EA+ +W+
Sbjct: 443 NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498
Query: 648 ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685
H SE R +NL + G ++ V G GSGKSSL+SA+L
Sbjct: 499 RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558
Query: 686 GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745
EM + G + ++G+ AYVPQQ+WI +G I++NIL G +++ RY QVL C+L DLE+
Sbjct: 559 EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805
LP GD+ EIGE+G+NLSGGQKQRISLARA Y + IYLLDDPLSAVDAHVGKHIF + +
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 806 PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865
L+GKT +LVTH + +L +I++L NG I E G++S L+ KKG++A+ ++
Sbjct: 679 KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733
Query: 866 TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925
+EAT ++ +D A I + + + +
Sbjct: 734 ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761
Query: 926 SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985
SL SL N N++ E + L ++E +E G + + +Y Y+QA G + + II
Sbjct: 762 SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811
Query: 986 FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030
FV+ V I S WLS W T+ S+ N T D P Q VYG
Sbjct: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869
Query: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082
L + GIF + AS LH +L N + R PM FFDT P GR++N
Sbjct: 870 ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142
FAGD+ +D LP ++ L +I+ L+++ + +P ++ + +I M +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202
+RL++ +RSP++SH ++ GL I + + F+ + D + +++
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262
S RW+A+RLE++ NL AL + + ++ L + + R+ E
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
E AVERI +Y K+ +EAP + P WP G+I F +Y ++YR VL GI
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
I E +G+VGRTG+GKSSL LFR++E G+I+IDGVDI SIGL DLR KL++I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
PQDP+L SG++R NLDPF+ ++D++IW ALE L ++ L +V E GGN S+G
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVG 1281
Query: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
+RQLLC+ RA+LR SKI+++DEATA++D+ETD LIQ TI+ F CTV+ IAHR+ T+++
Sbjct: 1282 ERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1341
Query: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
D ++V+ NGK++E PE L + PG +
Sbjct: 1342 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 591 bits (1524), Expect = e-168
Identities = 390/1229 (31%), Positives = 625/1229 (50%), Gaps = 171/1229 (13%)
Query: 367 LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426
LF + ++S + + + ++ R A+ + ++K + ++ T GE ++ +
Sbjct: 209 LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266
Query: 427 DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486
D L + + ++ + +V+ + +G + + +LV P+ ++ +
Sbjct: 267 DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326
Query: 487 IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546
Q + D+R+++ +E+L+ IK++K + WE F +++LR+KE K L +Q +
Sbjct: 327 AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386
Query: 547 IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604
+T ++ V +V+VL+ ++ L A AF+ + N+LR + +P+ + +
Sbjct: 387 ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442
Query: 605 QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647
+ + R +K+ L S + + KA+ F EA+ +W+
Sbjct: 443 NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498
Query: 648 ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685
H SE R +NL + G ++ V G GSGKSSL+SA+L
Sbjct: 499 RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558
Query: 686 GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745
EM + G + ++G+ AYVPQQ+WI +G I++NIL G +++ RY QVL C+L DLE+
Sbjct: 559 EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805
LP GD+ EIGE+G+NLSGGQKQRISLARA Y + IYLLDDPLSAVDAHVGKHIF + +
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 806 PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865
L+GKT +LVTH + +L +I++L NG I E G++S L+ KKG++A+ ++
Sbjct: 679 KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733
Query: 866 TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925
+EAT ++ +D A I + + + +
Sbjct: 734 ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761
Query: 926 SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985
SL SL N N++ E + L ++E +E G + + +Y Y+QA G + + II
Sbjct: 762 SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811
Query: 986 FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030
FV+ V I S WLS W T+ S+ N T D P Q VYG
Sbjct: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869
Query: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082
L + GIF + AS LH +L N + R PM FFDT P GR++N
Sbjct: 870 ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142
FAGD+ +D LP ++ L +I+ L+++ + +P ++ + +I M +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202
+RL++ +RSP++SH ++ GL I + + F+ + D + +++
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262
S RW+A+RLE++ NL AL + + ++ L + + R+ E
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
E AVERI +Y K+ +EAP + P WP G+I F +Y ++YR VL GI
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
I E +G+VGRTG+GKSSL LFR++E G+I+IDGVDI SIGL DLR KL++I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
PQDP+L SG++R NLDPF+ ++D++IW ALE
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----------------------------- 1252
Query: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
R L K+ I+++DEATA++D+ETD LIQ TI+ F CTV+ IAHR+ T+++
Sbjct: 1253 --------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
Query: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
D ++V+ NGK++E PE L + PG +
Sbjct: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 443 bits (1139), Expect = e-124
Identities = 295/940 (31%), Positives = 483/940 (51%), Gaps = 104/940 (11%)
Query: 189 ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKR 248
E NP A+ S + + W + + G+KR L +D++ V E +++ L + + +
Sbjct: 7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDK 66
Query: 249 ELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKS 308
E+ +A + D K
Sbjct: 67 EVLRA------------------------------------------------ENDAQKP 78
Query: 309 WLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTY----LWIGYLCA 364
L +A+ K ++ L + L+ + + P L +I++ + D L Y A
Sbjct: 79 SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYA 138
Query: 365 ILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLM 424
+L LI + YF G+++R A+ +Y+KAL LSN+A + T G+ VNL+
Sbjct: 139 TVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLL 198
Query: 425 SVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS 484
S D K VT F+H LW+ LQ + LW E+G S LAG+ V+++++P+ +
Sbjct: 199 SNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLF 258
Query: 485 KTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQC 544
+++ K D R++ MNE+++GI+I+K +AWE SF + + NLRKKE+ +L S L+
Sbjct: 259 SSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG 318
Query: 545 VVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSML-PMMISSM 603
+ + F ++ VTF+ YVL+ S ++ A + F ++TL+ +R +++ P I +
Sbjct: 319 MNLASFFSASKIIVFVTFTTYVLLGS--VITASRVFVAVTLYGAVRLTVTLFFPSAIERV 376
Query: 604 LQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEA-TVRDVNLDIM 662
+A VS R++ +L D++ + + K + + + W+ SE T++ ++ +
Sbjct: 377 SEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVR 436
Query: 663 AGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFG 722
G+L+AV+GPVG+GKSSL+SA+LGE+ HG +++ G AYV QQ W+ +GT++ NILFG
Sbjct: 437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
Query: 723 TEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
++ ++RY++V++ACAL DL++L GDL IG++G LSGGQK R++LARA YQ+ DIY
Sbjct: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
Query: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
LLDDPLSAVDA V +H+F + +L K +LVTH + +L +I++L +G +V+K
Sbjct: 557 LLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
Query: 843 GSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASIT 902
G+Y+ L +F LK D E E P + T
Sbjct: 615 GTYTEFLKSGIDFGSLLK--------------KDNEESEQ------------PPVPGTPT 648
Query: 903 MRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV 962
+R RT S SS + +S R SLK + S +D E V + +E GKV
Sbjct: 649 LR-----NRTFSESSVWS---QQSSRPSLKDGALES--QDTENV--PVTLSEENRSEGKV 696
Query: 963 KFSIYLEYLQAIGLFSIF-FIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST----DYPA 1017
F Y Y +A + +F F+IL VA++ + WLS W + + N T
Sbjct: 697 GFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT 756
Query: 1018 SQRDMR--VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTT 1075
+ D+ +G+Y L +A +F + V++S LH ++ +IL+AP+ FFD
Sbjct: 757 EKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRN 816
Query: 1076 PTGRIVNRFAGDISTVDDTLPQSLRSWITCF-LGIISTLV 1114
P GRI+NRF+ DI +DD LP + +I + L ++S LV
Sbjct: 817 PIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLSWLV 856
Score = 97.8 bits (242), Expect = 7e-20
Identities = 105/473 (22%), Positives = 205/473 (43%), Gaps = 63/473 (13%)
Query: 1075 TPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVM------ICMATPVFTIIVI 1128
T TG+IVN + D++ D W I T ++ C+A II++
Sbjct: 189 TTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL 248
Query: 1129 PLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRF------ 1182
PL + ++F S+ D+ R+ +E ++G+ +I+ + ++ F
Sbjct: 249 PLQSCFG--KLFSSLRSKTATFTDARIRT-----MNEVITGIRIIKMYAWEKSFSNLITN 301
Query: 1183 LKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVL 1242
L+ E+ C+ NL FFSA ++++ + +G V+
Sbjct: 302 LRKKEISKILRSSCLRGM---------------NLASFFSASKIIVFVTFTTYVLLGSVI 346
Query: 1243 S-NALNITQTLNWLVRMT---------SEIETNIVAVERITEYTKVENEAPWVTDKRPPP 1292
+ + + + TL VR+T + IV++ RI + ++ + +++ P
Sbjct: 347 TASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ--RNRQLPS 404
Query: 1293 DWPSKGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
D K + ++ + + L+G++ + E + VVG GAGKSSL + + L
Sbjct: 405 D--GKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGEL 462
Query: 1352 EAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALE 1411
+ G + + G ++ + Q P +FSG+LR N+ Y E K ++
Sbjct: 463 APSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIK 509
Query: 1412 LAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLET 1471
LK + L+ G + + G LS GQ+ + L RA+ + + I +LD+ +AVD E
Sbjct: 510 ACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEV 569
Query: 1472 D-NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQ 1523
+L + I I + H+L + + ++++L +GK+++ G+ E L+
Sbjct: 570 SRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLK 622
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 325 bits (834), Expect = 2e-88
Identities = 202/567 (35%), Positives = 316/567 (55%), Gaps = 41/567 (7%)
Query: 8 STFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYL 66
S FW+S+ + + DL CF+ ++L W+P +LW+ P LL Y R +L
Sbjct: 12 SKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHL 69
Query: 67 AK-QVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV--LLIQYSRQW 123
+K ++ +G LL + PA + L +G +L+ LLIQY R
Sbjct: 70 SKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQ 129
Query: 124 CVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFISYGFQILILIFS 182
VQ +S L +FW L ++C F++ ++ +G+ S+ F+I + + LI +
Sbjct: 130 GVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILA 188
Query: 183 AFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
F E N + + P + A FLS + + W+ + + GY+ PL +D+W + EE +
Sbjct: 189 CFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDR 248
Query: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEK 294
++ +V ++L +A R+QEK + ++ + PG N + +D ++L +
Sbjct: 249 SQMVV--------QQLLEA----WRKQEKQTARHKASAAPGKN---ASGEDEVLLGARPR 293
Query: 295 KKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRD 354
+K S +KAL TF L S KL+ D+ +F++PQLL +LI F S+
Sbjct: 294 PRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPM 343
Query: 355 TYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKE 414
W G+L A L+F +++QS LQ Y+ F GVK RT IM +Y+KAL ++N ++
Sbjct: 344 APSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRA 403
Query: 415 YTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVI 474
TVGE VNLMSVDAQ+ MD+ F+++LWS+ LQI+L+I+FLW+ LGPSVLAGV MVL+I
Sbjct: 404 STVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLI 463
Query: 475 PINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
P+N ++ K + QVK MK KD R+K+M+EIL+GIK+LK +AWEPSF QV+ +R+ EL+
Sbjct: 464 PLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ 523
Query: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVT 561
L + L F + +P LV + T
Sbjct: 524 LLRTAAYLHTTTTFTWMCSPFLVRLGT 550
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 280 bits (715), Expect = 1e-74
Identities = 161/519 (31%), Positives = 286/519 (55%), Gaps = 37/519 (7%)
Query: 1036 IFVFIAHFWSAFGF----------VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
I+V +A A GF + S ILH ++L+++L+APM +T G I+NRF+
Sbjct: 918 IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFS 977
Query: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
DI+ +DD LP ++ +I L +I + ++ + P + +P+ + ++ ++ +++ TS
Sbjct: 978 KDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTS 1037
Query: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRF--LKHNEVRIDTNQKCVFSWITS 1203
+QL++L+S RSPI++H ++ GL +RAF Q F L H + + T F ++++
Sbjct: 1038 QQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW--FLYLST 1095
Query: 1204 NRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD-TVGFVLSNALNITQTLNWLVRMTSEI 1262
RW +R+E++ +FF A+ + T G+ VG +L+ A+NI TL W V + ++
Sbjct: 1096 LRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDV 1153
Query: 1263 ETNIVAVERITEYTKVENEAPWVTDKRPPPD-------------------WPSKGKIQFN 1303
++ + +V R+ ++ + E +P + WPS G++
Sbjct: 1154 DSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVK 1213
Query: 1304 NYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363
+ +Y + +L I+ I +++G++GRTG+GKS+L + R+L G +I IDGV
Sbjct: 1214 DLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEG-EIQIDGV 1272
Query: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423
SI L R+ +IPQ +FSG+ R NLDP+ +SD+EIWK + L+S +
Sbjct: 1273 SWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Query: 1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEF 1483
L + + G LS G +QL+CL R++L K+KIL+LDE +A +D T +I+ T++ F
Sbjct: 1333 GKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAF 1392
Query: 1484 AHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
A CTVI HR+ +++ + +V++ K+ + S ++LL
Sbjct: 1393 ADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL 1431
Score = 240 bits (613), Expect = 7e-63
Identities = 181/698 (25%), Positives = 314/698 (44%), Gaps = 88/698 (12%)
Query: 193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252
+P AS +S + +SW I+ KGY++ L L D++++ L K E R
Sbjct: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDR---- 59
Query: 253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
E +S++N PK L+
Sbjct: 60 ---------ELASKKN-------------------------------------PK--LIN 71
Query: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL-KLLISFASDRDTYLWIGYLCAILLFTAA 371
AL + F+ + + + ++ V P LL +++ S+ D I I L
Sbjct: 72 ALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF 131
Query: 372 LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL 431
++++ L +G+++R A+ + +YKK L LS+ + ++G+ V+L+S + K
Sbjct: 132 IVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKF 191
Query: 432 MDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKN 491
+ H +W + LQ+ L + +W L S G+G ++++ A L + +
Sbjct: 192 DEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQR 251
Query: 492 MKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQ 551
+RL I +E++ I+ +K + WE + ++NLR+ ELK + ++ F
Sbjct: 252 AGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFF 311
Query: 552 LTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS-MLPMMISSMLQASVST 610
+ V ++ Y L+ + +K FT+I+ +LR ++ P + + + +
Sbjct: 312 FSGFFVVFLSVLPYALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAI 368
Query: 611 ERLEKYLGGDDLDTSAIRHDCN------------------FDKAMQFSEASFTWEHDSEA 652
+++ +L + T F+KA Q + T D
Sbjct: 369 NKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSL 428
Query: 653 -----------TVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT 701
++D+N I GQL+AV G G+GK+SL+ ++GE+E G I G
Sbjct: 429 FFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRI 488
Query: 702 AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINL 761
++ Q SWI GTIK+NI+FG ++E RY+ V++AC L D+ D +GE GI L
Sbjct: 489 SFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITL 548
Query: 762 SGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHS 821
SGGQ+ RISLARA Y++ D+YLLD P +D K IF + L+ KTR+LVT
Sbjct: 549 SGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSK 606
Query: 822 MHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL 859
M L + D+I++L G+ G++S L + +F+ L
Sbjct: 607 MEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
Score = 76.6 bits (187), Expect = 2e-13
Identities = 104/474 (21%), Positives = 194/474 (40%), Gaps = 42/474 (8%)
Query: 418 GETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSV-LAGVGVMVLVIPI 476
G +N S D L D+ + +L IV+ + L P + +A V V+V I +
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIML 1029
Query: 477 NAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKN- 535
A S+ ++ + + + L G+ L+ F +P F N
Sbjct: 1030 RAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW 1089
Query: 536 -----LLAFSQLQCVVIFV-FQLTPVLVSVVTFSV------YVLVDSNNILDAQK--AFT 581
L + Q++ +IFV F + +S++T +L + NI+ + +
Sbjct: 1090 FLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNS 1149
Query: 582 SITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGD-----DLDTSAIRHDCNFDKA 636
SI + +++R + + M T+ + Y G ++ S ++ D +
Sbjct: 1150 SIDVDSLMRSVSRVFKFI--DMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSG 1207
Query: 637 MQFSEASFT--WEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGH 694
Q + T + A + +++ I GQ V ++G GSGKS+L+SA L + N G
Sbjct: 1208 GQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGE 1266
Query: 695 ITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLP 741
I I G + +PQ+ +I +GT + N+ +++++ +V + L
Sbjct: 1267 IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRS 1326
Query: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
+E PG + + G LS G KQ + LAR+ I LLD+P + +D V I
Sbjct: 1327 VIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIR 1385
Query: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
+ L T +L H + + + + +V+ + + S LL ++ F
Sbjct: 1386 RTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
Score = 60.1 bits (144), Expect = 2e-08
Identities = 101/554 (18%), Positives = 210/554 (37%), Gaps = 65/554 (11%)
Query: 1016 PASQRDMRVGVYGALGLAQGIFVFIAHFWSA-FGFVHASNILHKQLLNNI----LRAPMR 1070
P ++ + + +Y +GL V A FG H + + + I L+ R
Sbjct: 111 PDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSR 170
Query: 1071 FFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCF-LGIISTLVMICMATPVFTIIVIP 1129
D G++V+ + +++ D+ L + WI + ++ L+ + F
Sbjct: 171 VLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC----G 226
Query: 1130 LGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHF---SETVSGLPVIRAFEHQQRFLKHN 1186
LG + V + +F R + + I SE + + ++A+ ++ K
Sbjct: 227 LGFLIV-LALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
Query: 1187 EVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD---TVGFVLS 1243
E T K + + G VF S L + + + T+ F +
Sbjct: 286 ENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV 345
Query: 1244 NALNITQTLNWLVRMTSE-------------------IETNIVAVERITE---------Y 1275
+ +T+ W V+ + +E N+ E + E +
Sbjct: 346 LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGF 405
Query: 1276 TKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGR 1335
++ +A + R + + F+N+ + P VL+ I I + + V G
Sbjct: 406 GELFEKAKQNNNNRKTSN--GDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGS 459
Query: 1336 TGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNL 1395
TGAGK+SL + LE + G+I G +++ Q + G+++ N+
Sbjct: 460 TGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGTIKENI 506
Query: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKS 1455
+Y + ++ L+ ++ + + E G LS GQR + L RA+ + +
Sbjct: 507 IFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDA 566
Query: 1456 KILVLDEATAAVDLETD-NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIE 1514
+ +LD +D+ T+ + ++ + A+ T I + ++ + +DK+++L G
Sbjct: 567 DLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYF 626
Query: 1515 CGSPEELLQIPGPF 1528
G+ EL + F
Sbjct: 627 YGTFSELQNLQPDF 640
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 240 bits (612), Expect = 9e-63
Identities = 238/936 (25%), Positives = 414/936 (44%), Gaps = 88/936 (9%)
Query: 632 NFDKAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMEN 690
N ++F F++ E + + +NL + +GQ VA++G G GKS+ + M +
Sbjct: 387 NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDP 446
Query: 691 VHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTE-FNEKRYQQVLEA 736
G +++ G V Q+ + TI +NI +G E ++ ++
Sbjct: 447 TEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 506
Query: 737 CALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVG 796
+ LP +GE+G LSGGQKQRI++ARA +N I LLD+ SA+D
Sbjct: 507 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-S 565
Query: 797 KHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA 856
+ + L + KG+T +++ H + + D I +G IVEKG++ L+ +KG +
Sbjct: 566 EAVVQVAL--DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
Query: 857 KNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRS 916
K + ++ G E E D+ I ++E D+ S +R+ RS
Sbjct: 624 KLVT--MQTAGNEVEL-----ENAADESKSEIDALEMSSNDSRSSLIRK---------RS 667
Query: 917 SRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGL 976
+R + R ++ L T+ +L E V +++K E ++ + GL
Sbjct: 668 TRRSVRGSQAQDRKLSTKE--ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIING-GL 724
Query: 977 FSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGI 1036
F II + ++ +F D P ++R ++ L LA GI
Sbjct: 725 QPAFAIIFSKIIG-------------------VFTRIDDPETKRQ-NSNLFSLLFLALGI 764
Query: 1037 FVFIAHFWSAFGFVHASNILHKQL----LNNILRAPMRFFDT--TPTGRIVNRFAGDIST 1090
FI F F F A IL K+L ++LR + +FD TG + R A D +
Sbjct: 765 ISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQ 824
Query: 1091 VDDTLPQSLRSWITCFLGIISTLVMICMA----TPVFTIIVIPLGIIYVSVQMFYVS--- 1143
V + L + IT + + T ++I + + ++P+ I V+M +S
Sbjct: 825 VKGAIGSRL-AVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 883
Query: 1144 --TSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWI 1201
++L + I + TV L + FEH R + +F
Sbjct: 884 LKDKKELEGSGKIATEAIENF--RTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
Query: 1202 TSNRWLAIRLELVG--NLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMT 1259
S + G + A ++ + D L V+ A+ + Q ++
Sbjct: 942 FSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLL--VFSAVVFGAMAVGQVSSFA---P 996
Query: 1260 SEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-VLR 1318
+ I A I K + T+ P +G + F Y D+ VL+
Sbjct: 997 DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTL--EGNVTFGEVVFNYPTRPDIPVLQ 1054
Query: 1319 GITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLT 1378
G++ ++ + + +VG +G GKS++ L R + G++++DG +I + + LR L
Sbjct: 1055 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLG 1114
Query: 1379 IIPQDPILFSGSLRMNLDPFNN---YSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
I+ Q+PILF S+ N+ +N S EEI +A + A++ +F+ SL S +V + G
Sbjct: 1115 IVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGT 1174
Query: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
LS GQ+Q + + RAL+R+ IL+LDEAT+A+D E++ ++Q + T I IAHRL
Sbjct: 1175 QLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1234
Query: 1496 HTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFM 1531
TI ++D ++V NG++ E G+ ++LL G ++ M
Sbjct: 1235 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 160 bits (406), Expect = 7e-39
Identities = 142/551 (25%), Positives = 258/551 (46%), Gaps = 37/551 (6%)
Query: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK- 1058
+S T+ S I ++ + + DM Y G+ G+ V A+ +F + A +HK
Sbjct: 89 MSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLV-AAYIQVSFWCLAAGRQIHKI 147
Query: 1059 --QLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVD----DTLPQSLRSWITCFLGIIST 1112
Q + I+R + +FD G + R D+S ++ D + +S T F G I
Sbjct: 148 RKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVG 207
Query: 1113 LVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFS------ET 1166
T V I LG+ S + + L S T + ++ E
Sbjct: 208 FTRGWKLTLVILAISPVLGL----------SAAVWAKILSSFTDKELLAYAKAGAVAEEV 257
Query: 1167 VSGLPVIRAFEHQQRFLKHNEVRIDTNQKC-VFSWITSNRWLAIRLELVGNLTVFFSALM 1225
++ + + AF Q++ L+ ++ ++ + IT+N + L ++ S +
Sbjct: 258 LAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAF-----LLIYASYAL 312
Query: 1226 MVIYRDTL--SGD-TVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEA 1282
Y TL SG+ ++G VL+ ++ + + + IE A E K+ +
Sbjct: 313 AFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNK 372
Query: 1283 PWVTDKRPPPDWPS--KGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAG 1339
P + P KG ++F N Y ++ +L+G+ + S + + +VG +G G
Sbjct: 373 PSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCG 432
Query: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PF 1398
KS+ + R+ + G + +DG DI +I + LRE + ++ Q+P+LF+ ++ N+
Sbjct: 433 KSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGR 492
Query: 1399 NNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKIL 1458
N + +EI KA++ A+ F+ L V E G LS GQ+Q + + RAL+R KIL
Sbjct: 493 ENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL 552
Query: 1459 VLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSP 1518
+LDEAT+A+D E++ ++Q + T I IAHRL T+ ++D + D+G I+E G+
Sbjct: 553 LLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNH 612
Query: 1519 EELLQIPGPFY 1529
+EL++ G ++
Sbjct: 613 DELMKEKGIYF 623
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 218 bits (554), Expect = 5e-56
Identities = 289/1244 (23%), Positives = 522/1244 (41%), Gaps = 158/1244 (12%)
Query: 368 FTAALIQSFCLQCYFQLCFKLGVKVRTAI-MASVYKKALTLSNLARKEY-TVGETVNLMS 425
+ A + + + Y Q+CF + R M Y + + + + +VGE S
Sbjct: 144 YYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFS 203
Query: 426 VDAQKLMD-----VTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL 480
D K+ D + F+ + S++ +L F W+ + +++I ++ ++
Sbjct: 204 DDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK-----------LTLVIISVSPLI 252
Query: 481 STKSKTIQVKNMKNKDKRLK-------IMNEILSGIKILKYFAWEPSFRDQVQNLRKKEL 533
+ TI + K D LK + +E++S ++ + F E ++ +
Sbjct: 253 GIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYE------- 305
Query: 534 KNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLV---DSNNILDAQKAFTSITLFNI-L 589
KNL+ + V V + F Y L S +LD + +T TL I L
Sbjct: 306 KNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLD-EGEYTPGTLVQIFL 364
Query: 590 RFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKA---------MQFS 640
+ L + +S + +T R + +D I DC + ++F
Sbjct: 365 SVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPII-DCMSEDGYKLDRIKGEIEFH 423
Query: 641 EASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG 699
+F + E + D+N+ I G++ A++GP G+GKS+ + + + G +T+ G
Sbjct: 424 NVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
Query: 700 -------------TTAYVPQQSWIQNGTIKDNILFGTE--FNEKRYQQVLEACALLPDLE 744
V Q+ + + TI +NI +G E E Q EA A ++
Sbjct: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMD 543
Query: 745 MLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVL 804
+ D +GE G +SGGQKQR+++ARA +N I LLD SA+D + + + +VL
Sbjct: 544 LPQQFDTL-VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVL 601
Query: 805 GPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLR 864
+ G T + V H + + D I+ +GT VE+G++ LL +KG + + +
Sbjct: 602 SK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQ 659
Query: 865 HTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRR---ENSFRRTLSRSSRSNG 921
E + D +E+ D + T R ++S R ++ + S+S
Sbjct: 660 GNQALNEEDIKDATED----------------DMLARTFSRGSYQDSLRASIRQRSKSQL 703
Query: 922 RHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV----KFSIYLEYLQAIGLF 977
+L + ++ +ED K + + +E +E V KFS +G
Sbjct: 704 SYLVHEPPLAVVDHKSTYEEDR---KDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVG-- 758
Query: 978 SIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIF 1037
S+ + V AF+ S + L ++ K QR GV L +A G
Sbjct: 759 SVGAAVNGTVTPLYAFLFSQI-LGTFSIPDK--------EEQRSQINGVC-LLFVAMGCV 808
Query: 1038 VFIAHFWSAFGFVHASNILHKQLLNNILRAPM----RFFDT--TPTGRIVNRFAGDISTV 1091
F + F + +L K+L RA + +FD G + R A D S V
Sbjct: 809 SLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQV 868
Query: 1092 DDTLPQSLRSWITCFLGI-ISTLVMICMATPVFTIIVIPLGIIYVS----VQMFYVSTSR 1146
+ + F + ++ ++ + + +I+ + +S +M SR
Sbjct: 869 QGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASR 928
Query: 1147 QLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW 1206
+ L+ V + +E +S + + ++RF++ E ++ K
Sbjct: 929 DKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQ------- 976
Query: 1207 LAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNI 1266
+ + G F +M + ++ S G+++SN +++ R+ S + +
Sbjct: 977 ---KANIYGFCFAFAQCIMFIA--NSASYRYGGYLISNE---GLHFSYVFRVISAVVLSA 1028
Query: 1267 VAVERITEYTKVENEAP-------WVTDKRPP--------PDWPS-KGKIQFNNYQVRY- 1309
A+ R YT +A + D++PP W + +GKI F + + Y
Sbjct: 1029 TALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP 1088
Query: 1310 -RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASI 1368
RP+ VL G++ I + + VG +G GKS+ L R + G+++IDG D +
Sbjct: 1089 SRPDSQ-VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
Query: 1369 GLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSD---EEIWKALELAHLKSFVASLQLG 1425
+ LR + I+ Q+P+LF+ S+ N+ +N + E + A + A L FV SL
Sbjct: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
Query: 1426 LSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAH 1485
V G LS G++Q + + RA++R KIL+LDEAT+A+D E++ +Q +
Sbjct: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
Query: 1486 CTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
T I IAHRL TI ++D + V+ G +IE G+ EEL+ G +Y
Sbjct: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
Score = 102 bits (254), Expect = 3e-21
Identities = 100/408 (24%), Positives = 179/408 (43%), Gaps = 30/408 (7%)
Query: 480 LSTKSKTIQVKNMKNKDKRL-----KIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
LS ++T + ++DK+ +I NE LS I+ + E F + ++ +K K
Sbjct: 913 LSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK 972
Query: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS 594
+ + + Q + + ++ + SN L F I+ + L
Sbjct: 973 TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 595 MLPMMISSMLQASVSTERLEKYLGGDD----LDTSAIRHDCNFDKAMQFSEASFTWEHDS 650
S +A +S R + L +T+ + D NF + F + FT+
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD-NFQGKIDFVDCKFTYPSRP 1091
Query: 651 EATVRD-VNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG---------- 699
++ V + +++ I GQ +A +G G GKS+ I + + G + I G
Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQF 1151
Query: 700 ---TTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEAC--ALLPDLEM-LPGGDLAE 753
V Q+ + +I DNI +G E ++V+ A A L D M LP
Sbjct: 1152 LRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETN 1211
Query: 754 IGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGK 813
+G +G LS G+KQRI++ARA ++ I LLD+ SA+D K + + + +G+
Sbjct: 1212 VGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVALDKAREGR 1268
Query: 814 TRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
T +++ H + + D I V+ G ++EKG++ L+A+KG + K + T
Sbjct: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 202 bits (513), Expect = 3e-51
Identities = 206/849 (24%), Positives = 376/849 (44%), Gaps = 102/849 (12%)
Query: 704 VPQQSWIQNGTIKDNILFGTE--FNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINL 761
V Q+ + TI +NI +G + +E+ + EA A +E P +GEKG +
Sbjct: 22 VSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVGEKGAQM 80
Query: 762 SGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHS 821
SGGQKQRI++ARA +N I +LD+ SA+D+ K L KG+T ++V H
Sbjct: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKAS--KGRTTIVVAHR 137
Query: 822 MHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEE 881
+ + D IV L +G + EKG+++ L+AK+G +
Sbjct: 138 LSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLY-------------------------- 171
Query: 882 DDDYGLISS--VEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Y L+ S +++ E S+T E R+T NSL +V S+
Sbjct: 172 ---YSLVMSQDIKKADEQMESMTYSTE---RKT----------------NSLPLHSVKSI 209
Query: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
K D + K ++ + + I +V L+ + F + + + + +V + S ++
Sbjct: 210 KSDF-IDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIF 268
Query: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
T +F + D + D + Y + + G+ F+++F + A IL +
Sbjct: 269 AKIIT----MFGNNDKTTLKHDAEI--YSMIFVILGVICFVSYFMQGLFYGRAGEILTMR 322
Query: 1060 LLNNILRAPM----RFFDT--TPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTL 1113
L + +A + +FD TG + A DI+ + + + ++
Sbjct: 323 LRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSV 382
Query: 1114 VMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVI 1173
++ + T +++ + + M + D +E + + I
Sbjct: 383 IISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTI 442
Query: 1174 RAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTL 1233
+ ++ F + E + T +R + + +++G+ F A + Y
Sbjct: 443 VSLTREKAFEQMYEEMLQTQ----------HRNTSKKAQIIGSCYAFSHAFIYFAYA--- 489
Query: 1234 SGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERIT--EYTKVENEAPWV---TDK 1288
+G G L A +T ++V + + EY+K ++ A + +K
Sbjct: 490 AGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEK 549
Query: 1289 RPPPDWPSK---------GKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTG 1337
+P D S+ G ++F Y RP++ +LRG++ I + + VG +G
Sbjct: 550 KPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSG 608
Query: 1338 AGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDP 1397
GKS+ L R+ + GQ++ DGVD + + LR ++ I+PQ+P+LF+ S+ N+
Sbjct: 609 CGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAY 668
Query: 1398 FNNYSD---EEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRK 1454
+N +EI +A A++ SF+ L + +V G LS GQ+Q L + RALL+K
Sbjct: 669 GDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
Query: 1455 SKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIE 1514
KIL+LDEAT+A+D +++ ++Q + T + + HRL I ++D ++VL NGKI E
Sbjct: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
Query: 1515 CGSPEELLQ 1523
G+ +ELL+
Sbjct: 789 QGTHQELLR 797
Score = 110 bits (274), Expect = 1e-23
Identities = 140/659 (21%), Positives = 273/659 (41%), Gaps = 77/659 (11%)
Query: 246 MKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKK-D 304
M ++++KA ++ + ++ + L + +S + ++K ++ + +K+
Sbjct: 176 MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKS--------DFIDKAEESTQSKEIS 227
Query: 305 VPKSWLMKAL------FKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLL-----ISFASDR 353
+P+ L+K L + + L S L V+ +F+ + +++ + + D
Sbjct: 228 LPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDA 287
Query: 354 DTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLA-- 411
+ Y I + ++ F + +Q L + ++ T + + KA+ ++A
Sbjct: 288 EIYSMIFVILGVICFVSYFMQG--------LFYGRAGEILTMRLRHLAFKAMLYQDIAWF 339
Query: 412 -RKEYTVGETVNLMSVDAQKLMDVTNF-MHMLWSSVLQIVLSIFFLWRELGPSVLAGVGV 469
KE + G ++++D ++ T + +L + + LS+ S + G +
Sbjct: 340 DEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVII-------SFIYGWEM 392
Query: 470 MVLVIPINAILSTKS--KTIQVKNMKNKDKRL-----KIMNEILSGIKILKYFAWEPSFR 522
L++ I +L+ +T + NKDK+ KI E L I+ + E +F
Sbjct: 393 TFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFE 452
Query: 523 DQVQNLRKKELKNLLAFSQL--QCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAF 580
+ + + + +N +Q+ C + + F Y++ +
Sbjct: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIV 512
Query: 581 TSITLFNILRF--PLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQ 638
+ + + L + P + A+ LEK D + D + ++
Sbjct: 513 FTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLE 571
Query: 639 FSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITI 697
F E SF + + + R ++L I G+ VA +G G GKS+ + + + V G +
Sbjct: 572 FREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLF 631
Query: 698 KGTTA-------------YVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACA---LLP 741
G A VPQ+ + N +I +NI +G ++ EA +
Sbjct: 632 DGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHS 691
Query: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVD---AHVGKH 798
+E LP ++G KG LSGGQKQR+++ARA Q I LLD+ SA+D V +H
Sbjct: 692 FIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQH 751
Query: 799 IFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
+K G+T L+VTH + + D IVVL NG I E+G++ LL + + K
Sbjct: 752 ALDKA------RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFK 804
Score = 103 bits (256), Expect = 2e-21
Identities = 56/184 (30%), Positives = 103/184 (55%), Gaps = 1/184 (0%)
Query: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKS 1417
++D DI ++ + R+ + ++ Q+P+LF ++ N+ ++ +DEE+ +A A+
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1418 FVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQT 1477
F+ + V E G +S GQ+Q + + RAL+R KIL+LDEAT+A+D E+ + +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1478 TIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
++ T I +AHRL TI +D ++ L +G + E G+ EL+ G +Y + I
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 180
Query: 1538 ENVN 1541
+ +
Sbjct: 181 KKAD 184
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 182 bits (461), Expect = 3e-45
Identities = 151/496 (30%), Positives = 242/496 (48%), Gaps = 34/496 (6%)
Query: 1054 NILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDIS----TVDDTLPQSLRSWITCFLGI 1109
N L L ++ILR + FFD T TG ++NR + D + +V + L LR+ +GI
Sbjct: 245 NRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGI 304
Query: 1110 ISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFS---ET 1166
S + + F + V+P V + V R LR+L VT+ + E
Sbjct: 305 -SMMFFVSPNLATFVLSVVP------PVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEER 357
Query: 1167 VSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMM 1226
+ + +RAF + ++ ++D + + L GNL V +
Sbjct: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV-----LS 412
Query: 1227 VIYRDTL----SGDTVGFV---LSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVE 1279
V+Y+ L + TVG + L A + ++ L SE+ + A R+ E + E
Sbjct: 413 VLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
Query: 1280 NEAPWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTG 1337
+ P+ + + +G ++F N Y RPE+ + + + I S +VG +G
Sbjct: 473 PKLPF-NEGVILNEKSFQGALEFKNVHFAYPARPEVP-IFQDFSLSIPSGSVTALVGPSG 530
Query: 1338 AGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNL-- 1395
+GKS++ + L R+ + A G I +DG DI + LR K+ + Q+PILFS S+ N+
Sbjct: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 1396 --DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLR 1453
D ++ + EEI + E+A+ +F+ + G + V E G LS GQ+Q + + RALL+
Sbjct: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
Query: 1454 KSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKII 1513
KIL+LDEAT+A+D E + L+Q + TV+ IAHRL TI +++ V VLD GKI
Sbjct: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
Query: 1514 ECGSPEELLQIPGPFY 1529
E G EELL P Y
Sbjct: 711 EYGKHEELLSKPNGIY 726
Score = 112 bits (281), Expect = 2e-24
Identities = 129/543 (23%), Positives = 242/543 (44%), Gaps = 55/543 (10%)
Query: 351 SDRDTYLWIGYLCAILLFTAA-LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSN 409
SD T L +G L AA I+ + +Q Q ++ ++RT++ +S+ ++ + +
Sbjct: 208 SDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQ---RIVNRLRTSLFSSILRQEVAFFD 264
Query: 410 LARKEYTVGETVNLMSVDAQKL-MDVTNFMHMLWSSVLQIVLSI---FFLWRELGPSVLA 465
R GE +N +S D L VT + + Q + I FF+ L VL+
Sbjct: 265 KTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLS 320
Query: 466 GVG-VMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWE------ 518
V V ++ + L +K Q + + ++ E + ++ ++ F E
Sbjct: 321 VVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
Query: 519 -PSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQ 577
S D V L +KE AF++ +++SV+ ++ ++ +
Sbjct: 377 YASKVDHVMQLARKE-----AFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGEL 431
Query: 578 KAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD---LDTSAIRHDCNFD 634
+F + + + L S +++ + RL + L + + I ++ +F
Sbjct: 432 SSFLMYAFW--VGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQ 489
Query: 635 KAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHG 693
A++F F + E + +D +L I +G + A++GP GSGKS+++S +L + G
Sbjct: 490 GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASG 549
Query: 694 HITIKGTTAYVPQQSWIQN--GTIK-----------DNILFGTE----FNEKRYQQVLEA 736
I++ G W+++ GT+ +NI +G + + Q+V E
Sbjct: 550 TISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEV 609
Query: 737 CALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVG 796
+ + P G +GEKG+ LSGGQKQRI++ARA +N I LLD+ SA+DA
Sbjct: 610 ANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-N 668
Query: 797 KHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA 856
+++ + L + L+ G+T L++ H + + + + VL G I E G + LL+K
Sbjct: 669 EYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY 726
Query: 857 KNL 859
+ L
Sbjct: 727 RKL 729
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 168 bits (426), Expect = 3e-41
Identities = 127/512 (24%), Positives = 247/512 (48%), Gaps = 29/512 (5%)
Query: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
+ +G A G+ GIF I F + L L +++ FFD TG ++
Sbjct: 235 LAIGSSFAAGIRGGIFTLI--------FARLNIRLRNCLFRSLVSQETSFFDENRTGDLI 286
Query: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFY 1141
+R D + V D + Q++ ++ + + +V + + +++ I + V Y
Sbjct: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
Query: 1142 VSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQR----FLKHNEVRIDTNQKCV 1197
++L + + + ET+S + +R+F +++ +L+ + N+K
Sbjct: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257
+++ + L LV +++ + +VI SG+ + F++ + + + +
Sbjct: 407 AAYMYYVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDCMESVGS 464
Query: 1258 MTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-V 1316
+ S + + A E++ E+ ++ + V D PD +G++ F N YR V
Sbjct: 465 VYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQV 521
Query: 1317 LRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREK 1376
L+ ++ + + +VG +G+GKSS N L GG++++DG I++ L
Sbjct: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
Query: 1377 LTIIPQDPILFSGSLRMNLD------PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEV 1430
++++ Q+P+LF+ S+ N+ PF E + +A + A+ F+ LQ G S E
Sbjct: 582 ISLVSQEPVLFARSITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTET 636
Query: 1431 TEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVIT 1490
E G LS GQ+Q + + RAL+R +L+LDEAT+A+D E++ LIQ I TV+
Sbjct: 637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
Query: 1491 IAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
IAHRL T+ + ++VLD G++++ G+ ++LL
Sbjct: 697 IAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 728
Score = 103 bits (258), Expect = 1e-21
Identities = 114/511 (22%), Positives = 229/511 (44%), Gaps = 59/511 (11%)
Query: 382 FQLCF-KLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT----N 436
F L F +L +++R + S+ + + + E G+ ++ ++ D + D+ N
Sbjct: 250 FTLIFARLNIRLRNCLFRSLVSQETSFFD----ENRTGDLISRLTSDTTMVSDLVSQNIN 305
Query: 437 FMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKD 496
V +V+ +F L +L G ++++V + I K + +
Sbjct: 306 VFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMV---SNIYGKYYKRLSKEVQNALA 362
Query: 497 KRLKIMNEILSGIKILKYFAWEPSFRD-------QVQNLRKKELKNLLAFSQLQCVVIFV 549
+ E +S +K ++ FA E + QV L +KE + + + + V
Sbjct: 363 RASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLV 422
Query: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS----MLPMMISSMLQ 605
Q VS++ + ++ ++ Q ++ F I F L + + S ++Q
Sbjct: 423 VQ-----VSILYYGGHL------VISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ 471
Query: 606 ASVSTERLEKYLGGDD--LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIM 662
+ E++ +++ + ++ D + + + F +FT+ V ++V+ +
Sbjct: 472 GVGAAEKVFEFIDRQPTMVHDGSLAPD-HLEGRVDFENVTFTYRTRPHTQVLQNVSFSLS 530
Query: 663 AGQLVAVIGPVGSGKSSLISAML-------------GEMENVHGHITIKGTTAYVPQQSW 709
G++ A++GP GSGKSS ++ + G+ + + H + + V Q+
Sbjct: 531 PGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPV 590
Query: 710 IQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGEKGINLSGGQK 766
+ +I DNI +G ++ V+EA + L G E GEKG LSGGQK
Sbjct: 591 LFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
Query: 767 QRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLP 826
QR+++ARA +N + +LD+ SA+DA +++ + + +G L+ T L++ H + +
Sbjct: 649 QRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVE 705
Query: 827 QVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
IVVL G +V++G++ LLA+ G +AK
Sbjct: 706 HAHLIVVLDKGRVVQQGTHQQLLAQGGLYAK 736
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 168 bits (426), Expect = 3e-41
Identities = 127/512 (24%), Positives = 247/512 (48%), Gaps = 29/512 (5%)
Query: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
+ +G A G+ GIF I F + L L +++ FFD TG ++
Sbjct: 235 LAIGSSFAAGIRGGIFTLI--------FARLNIRLRNCLFRSLVSQETSFFDENRTGDLI 286
Query: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFY 1141
+R D + V D + Q++ ++ + + +V + + +++ I + V Y
Sbjct: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
Query: 1142 VSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQR----FLKHNEVRIDTNQKCV 1197
++L + + + ET+S + +R+F +++ +L+ + N+K
Sbjct: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257
+++ + L LV +++ + +VI SG+ + F++ + + + +
Sbjct: 407 AAYMYYVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDCMESVGS 464
Query: 1258 MTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-V 1316
+ S + + A E++ E+ ++ + V D PD +G++ F N YR V
Sbjct: 465 VYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQV 521
Query: 1317 LRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREK 1376
L+ ++ + + +VG +G+GKSS N L GG++++DG I++ L
Sbjct: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
Query: 1377 LTIIPQDPILFSGSLRMNLD------PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEV 1430
++++ Q+P+LF+ S+ N+ PF E + +A + A+ F+ LQ G S E
Sbjct: 582 ISLVSQEPVLFARSITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTET 636
Query: 1431 TEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVIT 1490
E G LS GQ+Q + + RAL+R +L+LDEAT+A+D E++ LIQ I TV+
Sbjct: 637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
Query: 1491 IAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
IAHRL T+ + ++VLD G++++ G+ ++LL
Sbjct: 697 IAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 728
Score = 103 bits (258), Expect = 1e-21
Identities = 114/511 (22%), Positives = 229/511 (44%), Gaps = 59/511 (11%)
Query: 382 FQLCF-KLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT----N 436
F L F +L +++R + S+ + + + E G+ ++ ++ D + D+ N
Sbjct: 250 FTLIFARLNIRLRNCLFRSLVSQETSFFD----ENRTGDLISRLTSDTTMVSDLVSQNIN 305
Query: 437 FMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKD 496
V +V+ +F L +L G ++++V + I K + +
Sbjct: 306 VFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMV---SNIYGKYYKRLSKEVQNALA 362
Query: 497 KRLKIMNEILSGIKILKYFAWEPSFRD-------QVQNLRKKELKNLLAFSQLQCVVIFV 549
+ E +S +K ++ FA E + QV L +KE + + + + V
Sbjct: 363 RASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLV 422
Query: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS----MLPMMISSMLQ 605
Q VS++ + ++ ++ Q ++ F I F L + + S ++Q
Sbjct: 423 VQ-----VSILYYGGHL------VISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ 471
Query: 606 ASVSTERLEKYLGGDD--LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIM 662
+ E++ +++ + ++ D + + + F +FT+ V ++V+ +
Sbjct: 472 GVGAAEKVFEFIDRQPTMVHDGSLAPD-HLEGRVDFENVTFTYRTRPHTQVLQNVSFSLS 530
Query: 663 AGQLVAVIGPVGSGKSSLISAML-------------GEMENVHGHITIKGTTAYVPQQSW 709
G++ A++GP GSGKSS ++ + G+ + + H + + V Q+
Sbjct: 531 PGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPV 590
Query: 710 IQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGEKGINLSGGQK 766
+ +I DNI +G ++ V+EA + L G E GEKG LSGGQK
Sbjct: 591 LFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
Query: 767 QRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLP 826
QR+++ARA +N + +LD+ SA+DA +++ + + +G L+ T L++ H + +
Sbjct: 649 QRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVE 705
Query: 827 QVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
IVVL G +V++G++ LLA+ G +AK
Sbjct: 706 HAHLIVVLDKGRVVQQGTHQQLLAQGGLYAK 736
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 159 bits (402), Expect = 2e-38
Identities = 140/527 (26%), Positives = 256/527 (48%), Gaps = 42/527 (7%)
Query: 1030 LGLAQGIFVFIAH--FWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGD 1087
L +A + F+ + + G VH+ L ++ +LR FF TG I++R D
Sbjct: 294 LTIASAVLEFVGDGIYNNTMGHVHSH--LQGEVFGAVLRQETEFFQQNQTGNIMSRVTED 351
Query: 1088 ISTVDDTLPQSLRSWI------TCFLGIISTLVMICMATPVFTIIVIPL-GIIYVSVQMF 1140
ST+ D+L ++L ++ C LGI ++ ++ + T+I +PL ++ V +
Sbjct: 352 TSTLSDSLSENLSLFLWYLVRGLCLLGI---MLWGSVSLTMVTLITLPLLFLLPKKVGKW 408
Query: 1141 YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQ----QRFLKHNEVRIDTNQKC 1196
Y Q+R +S+ +S + E +S +P +R+F ++ Q+F + + NQK
Sbjct: 409 YQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKE 464
Query: 1197 VFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLV 1256
++ N W ++ + + + +V SG+ V FVL + TQ + L+
Sbjct: 465 AVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ-MQFTQAVEVLL 522
Query: 1257 RMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPS----KGKIQFNNYQVRY--R 1310
+ ++ + + E+I EY T + PP + +G +QF + Y R
Sbjct: 523 SIYPRVQKAVGSSEKIFEYLDR-------TPRCPPSGLLTPLHLEGLVQFQDVSFAYPNR 575
Query: 1311 PELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGL 1370
P++ LVL+G+T + E +VG G+GKS++ L + + GGQ+++DG +
Sbjct: 576 PDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
Query: 1371 HDLREKLTIIPQDPILFSGSLRMNL--DPFNNYSDEEIWKALELAHLKSFVASLQLGLSH 1428
L ++ + Q+P +F SL+ N+ + EEI A + SF++ L G
Sbjct: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDT 694
Query: 1429 EVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQN--EFAHC 1486
EV EAG LS GQRQ + L RAL+RK +L+LD+AT+A+D + ++ + E
Sbjct: 695 EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR 754
Query: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
+V+ I L + +D ++ L+ G I E G+ ++L++ G ++ M +
Sbjct: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
Score = 102 bits (254), Expect = 3e-21
Identities = 106/491 (21%), Positives = 220/491 (44%), Gaps = 41/491 (8%)
Query: 392 VRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT--NFMHMLWSSVLQIV 449
V + + V+ L ++ G ++ ++ D L D N LW V +
Sbjct: 316 VHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 450 LSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS----KTIQVKNMKNKDKRLKIMNEI 505
L LW + ++ V ++ +P+ +L K + ++V+ ++ K ++ E
Sbjct: 376 LLGIMLWGSVSLTM-----VTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEA 430
Query: 506 LSGIKILKYFAWEPS----FRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
LS + ++ FA E FR+++Q ++ K +A++ V + ++ +L+ V
Sbjct: 431 LSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYA----VNSWTTSISGMLLKVGI 486
Query: 562 FSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD 621
+ + ++ + + T + + +L + + +A S+E++ +YL
Sbjct: 487 LYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTP 546
Query: 622 -LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSS 679
S + + + +QF + SF + + + V + + + G++ A++GP GSGKS+
Sbjct: 547 RCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKST 606
Query: 680 LISAMLGEMENVHGHITIKGT-------------TAYVPQQSWIQNGTIKDNILFGTEFN 726
+ + + + G + + G A V Q+ + ++++NI +G
Sbjct: 607 VAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG--LT 664
Query: 727 EKRYQQVLEACALLPD----LEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
+K + + A A+ + LP G E+ E G LSGGQ+Q ++LARA + +
Sbjct: 665 QKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVL 724
Query: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
+LDD SA+DA+ + ++L + ++ LL+T + + Q D I+ L G I E
Sbjct: 725 ILDDATSALDANSQLQV-EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREG 783
Query: 843 GSYSALLAKKG 853
G++ L+ KKG
Sbjct: 784 GTHQQLMEKKG 794
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,536,851
Number of Sequences: 37866
Number of extensions: 2210913
Number of successful extensions: 7795
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 7101
Number of HSP's gapped (non-prelim): 360
length of query: 1545
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1430
effective length of database: 13,892,928
effective search space: 19866887040
effective search space used: 19866887040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.