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Search of human proteins with 4557351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557351 butyrylcholinesterase precursor [Homo sapiens]
(602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557351 butyrylcholinesterase precursor [Homo sapiens] 1258 0.0
gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sa... 652 0.0
gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo sa... 602 e-172
gi|31317256 X-linked neuroligin 4 [Homo sapiens] 323 2e-88
gi|24308209 X-linked neuroligin 4 [Homo sapiens] 323 2e-88
gi|40538788 neuroligin 4, Y-linked [Homo sapiens] 322 6e-88
gi|30840978 neuroligin 2 [Homo sapiens] 312 5e-85
gi|51593088 neuroligin 3 [Homo sapiens] 306 3e-83
gi|7662470 neuroligin 1 [Homo sapiens] 303 2e-82
gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens] 281 9e-76
gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens] 267 2e-71
gi|148536848 carboxyl ester lipase precursor [Homo sapiens] 261 1e-69
gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens] 258 8e-69
gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens] 253 5e-67
gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens] 249 4e-66
gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens] 249 4e-66
gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens] 249 5e-66
gi|33563374 carboxylesterase 3 [Homo sapiens] 235 1e-61
gi|115529439 carboxylesterase 8 (putative) [Homo sapiens] 222 7e-58
gi|55770862 thyroglobulin [Homo sapiens] 220 3e-57
gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens] 132 1e-30
gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens] 132 1e-30
gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens] 84 4e-16
gi|68299767 arylacetamide deacetylase [Homo sapiens] 45 2e-04
gi|21328446 hormone-sensitive lipase [Homo sapiens] 42 0.002
gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens] 34 0.44
gi|68051721 arylacetamide deacetylase-like 1 isoform b [Homo sap... 33 0.75
gi|21361933 integrin alpha FG-GAP repeat containing 1 [Homo sapi... 33 0.75
gi|28872814 semaphorin 4G [Homo sapiens] 32 1.7
gi|4502613 cyclin A [Homo sapiens] 32 2.2
>gi|4557351 butyrylcholinesterase precursor [Homo sapiens]
Length = 602
Score = 1258 bits (3255), Expect = 0.0
Identities = 602/602 (100%), Positives = 602/602 (100%)
Query: 1 MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP 60
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
Sbjct: 1 MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP 60
Query: 61 YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC 120
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
Sbjct: 61 YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC 120
Query: 121 LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG 180
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
Sbjct: 121 LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG 180
Query: 181 FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG 240
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
Sbjct: 181 FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG 240
Query: 241 SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI 300
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
Sbjct: 241 SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI 300
Query: 301 LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY 360
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
Sbjct: 301 LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY 360
Query: 361 GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV 420
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
Sbjct: 361 GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV 420
Query: 421 VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER 480
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
Sbjct: 421 VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER 480
Query: 481 RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT 540
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
Sbjct: 481 RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT 540
Query: 541 KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV 600
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
Sbjct: 541 KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV 600
Query: 601 GL 602
GL
Sbjct: 601 GL 602
>gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo
sapiens]
Length = 614
Score = 652 bits (1683), Expect = 0.0
Identities = 312/596 (52%), Positives = 417/596 (69%), Gaps = 11/596 (1%)
Query: 17 LLLCML---IGKSHTED-DIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFK 72
LLL +L +G ED ++++ + G++RG+ L GG V+AFLGIP+A+PP+G RF
Sbjct: 20 LLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFL 79
Query: 73 KPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP 132
P+ WS + +AT + + C Q +D +PGF G+EMWNPN +LSEDCLYLNVW P P+P
Sbjct: 80 PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP 139
Query: 133 KNAT-VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191
+ T VL+WIYGGGF +G SSL VYDG+FL + ER ++VSMNYRVGA GFLALPG+ EAP
Sbjct: 140 TSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAP 199
Query: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251
GN+GL DQ+LALQWVQ+N+AAFGG+P SVTLFGESAGAASV +HLLSP S LF RA+LQ
Sbjct: 200 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQ 259
Query: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGC----SRENETEIIKCLRNKDPQEILLNEAFV 307
SG+ N PWA + EAR R LA L GC + N+TE++ CLR + Q ++ +E V
Sbjct: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHV 319
Query: 308 VPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSK 367
+P + +F P VDGDFL+D P+ L+ G F Q+LVGV KDEG+ FLVYGAPGFSK
Sbjct: 320 LPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSK 379
Query: 368 DNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFI 427
DN S+I+R EF G+++ P VS+ E+++ HYTDW+ + P REAL DVVGD+N +
Sbjct: 380 DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVV 439
Query: 428 CPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKA 487
CP + + + G + Y FEHR+S L WP WMGV HGYEIEF+FG+PL+ NYT
Sbjct: 440 CPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAE 499
Query: 488 EEILSRSIVKRWANFAKYGNPNETQN-NSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQ 546
E+I ++ +++ WANFA+ G+PNE ++ + WP + + Q+Y++L+ + LRAQ
Sbjct: 500 EKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQA 559
Query: 547 CRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL 602
C FW F PK+L T +DEAE +WKA FHRW++YM+ WKNQF+ Y SK++ C L
Sbjct: 560 CAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHY-SKQDRCSDL 614
>gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo
sapiens]
Length = 617
Score = 602 bits (1553), Expect = e-172
Identities = 289/557 (51%), Positives = 387/557 (69%), Gaps = 10/557 (1%)
Query: 17 LLLCML---IGKSHTED-DIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFK 72
LLL +L +G ED ++++ + G++RG+ L GG V+AFLGIP+A+PP+G RF
Sbjct: 20 LLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFL 79
Query: 73 KPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP 132
P+ WS + +AT + + C Q +D +PGF G+EMWNPN +LSEDCLYLNVW P P+P
Sbjct: 80 PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP 139
Query: 133 KNAT-VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191
+ T VL+WIYGGGF +G SSL VYDG+FL + ER ++VSMNYRVGA GFLALPG+ EAP
Sbjct: 140 TSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAP 199
Query: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251
GN+GL DQ+LALQWVQ+N+AAFGG+P SVTLFGESAGAASV +HLLSP S LF RA+LQ
Sbjct: 200 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQ 259
Query: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGC----SRENETEIIKCLRNKDPQEILLNEAFV 307
SG+ N PWA + EAR R LA L GC + N+TE++ CLR + Q ++ +E V
Sbjct: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHV 319
Query: 308 VPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSK 367
+P + +F P VDGDFL+D P+ L+ G F Q+LVGV KDEG+ FLVYGAPGFSK
Sbjct: 320 LPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSK 379
Query: 368 DNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFI 427
DN S+I+R EF G+++ P VS+ E+++ HYTDW+ + P REAL DVVGD+N +
Sbjct: 380 DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVV 439
Query: 428 CPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKA 487
CP + + + G + Y FEHR+S L WP WMGV HGYEIEF+FG+PL+ NYT
Sbjct: 440 CPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAE 499
Query: 488 EEILSRSIVKRWANFAKYGNPNETQN-NSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQ 546
E+I ++ +++ WANFA+ G+PNE ++ + WP + + Q+Y++L+ + LRAQ
Sbjct: 500 EKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQA 559
Query: 547 CRFWTSFFPKVLEMTGN 563
C FW F PK+L T +
Sbjct: 560 CAFWNRFLPKLLSATAS 576
>gi|31317256 X-linked neuroligin 4 [Homo sapiens]
Length = 816
Score = 323 bits (829), Expect = 2e-88
Identities = 192/564 (34%), Positives = 298/564 (52%), Gaps = 56/564 (9%)
Query: 33 IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKY 89
++ T GK+RG+ + G V +LG+PYA PP G RF+ P+ + W+ I N T++
Sbjct: 47 VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQF 106
Query: 90 ANSCCQNIDQSFPGFHGSEMW---NPNT------DLSEDCLYLNVWIPAP-----KPKNA 135
A C Q++D+ +W N +T D +EDCLYLN+++P +
Sbjct: 107 AAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKK 166
Query: 136 TVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMG 195
V+++I+GG + GT ++ DG LA VIV+++NYR+G LGFL+ G+ A GN G
Sbjct: 167 PVMVYIHGGSYMEGTGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYG 223
Query: 196 LFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSF 255
L DQ AL+W+++N+ AFGG+PK VT+FG AGA+ VSL LS S LF +AI+QSG+
Sbjct: 224 LLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Query: 256 NAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLS 315
+ WAV Y+ T LA GC+ + T++++CLRNK+ +E++ Y
Sbjct: 284 LSSWAVN--YQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATY----H 337
Query: 316 VNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR 375
+ FGP +DGD + D P IL+E G+F I++GVN+ EG F+ DN +T
Sbjct: 338 IAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTP 392
Query: 376 KEFQEGLKIF------FPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICP 429
+F + F +P + +E+I F YTDW D + PE R+ L + D+ ++ P
Sbjct: 393 NDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAP 452
Query: 430 ALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NY 484
A+ +++G+ +FY F H P W HG E+ +VFG+P+ N+
Sbjct: 453 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNF 512
Query: 485 TKAEEILSRSIVKRWANFAKYGNPNETQNNST-------------SWPVFKSTEQKYLTL 531
+K + +LS ++ W NFAK G+PN+ T +W + +Q YL +
Sbjct: 513 SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHI 572
Query: 532 NTESTRIMTKLRAQQCRFWTSFFP 555
+ R+ RA + FW P
Sbjct: 573 GLK-PRVRDHYRATKVAFWLELVP 595
>gi|24308209 X-linked neuroligin 4 [Homo sapiens]
Length = 816
Score = 323 bits (829), Expect = 2e-88
Identities = 192/564 (34%), Positives = 298/564 (52%), Gaps = 56/564 (9%)
Query: 33 IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKY 89
++ T GK+RG+ + G V +LG+PYA PP G RF+ P+ + W+ I N T++
Sbjct: 47 VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQF 106
Query: 90 ANSCCQNIDQSFPGFHGSEMW---NPNT------DLSEDCLYLNVWIPAP-----KPKNA 135
A C Q++D+ +W N +T D +EDCLYLN+++P +
Sbjct: 107 AAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKK 166
Query: 136 TVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMG 195
V+++I+GG + GT ++ DG LA VIV+++NYR+G LGFL+ G+ A GN G
Sbjct: 167 PVMVYIHGGSYMEGTGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYG 223
Query: 196 LFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSF 255
L DQ AL+W+++N+ AFGG+PK VT+FG AGA+ VSL LS S LF +AI+QSG+
Sbjct: 224 LLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Query: 256 NAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLS 315
+ WAV Y+ T LA GC+ + T++++CLRNK+ +E++ Y
Sbjct: 284 LSSWAVN--YQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATY----H 337
Query: 316 VNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR 375
+ FGP +DGD + D P IL+E G+F I++GVN+ EG F+ DN +T
Sbjct: 338 IAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTP 392
Query: 376 KEFQEGLKIF------FPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICP 429
+F + F +P + +E+I F YTDW D + PE R+ L + D+ ++ P
Sbjct: 393 NDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAP 452
Query: 430 ALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NY 484
A+ +++G+ +FY F H P W HG E+ +VFG+P+ N+
Sbjct: 453 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNF 512
Query: 485 TKAEEILSRSIVKRWANFAKYGNPNETQNNST-------------SWPVFKSTEQKYLTL 531
+K + +LS ++ W NFAK G+PN+ T +W + +Q YL +
Sbjct: 513 SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHI 572
Query: 532 NTESTRIMTKLRAQQCRFWTSFFP 555
+ R+ RA + FW P
Sbjct: 573 GLK-PRVRDHYRATKVAFWLELVP 595
>gi|40538788 neuroligin 4, Y-linked [Homo sapiens]
Length = 816
Score = 322 bits (825), Expect = 6e-88
Identities = 189/564 (33%), Positives = 298/564 (52%), Gaps = 56/564 (9%)
Query: 33 IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKY 89
++ T GK++G+ + G V +LG+PYA PP G RF+ P+S + W+ I NAT++
Sbjct: 47 VVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQF 106
Query: 90 ANSCCQNIDQSFPGFHGSEMWNPNT---------DLSEDCLYLNVWIPAP-----KPKNA 135
+ C Q++D+ F +W + D +EDCLYLN+++P +
Sbjct: 107 SAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDDIHEQNSKK 166
Query: 136 TVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMG 195
V+++I+GG + GT ++ DG LA VIV+++N R+G LGFL+ G+ A GN G
Sbjct: 167 PVMVYIHGGSYMEGTGNM--IDGSILASYGNVIVITINCRLGILGFLST-GDQAAKGNYG 223
Query: 196 LFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSF 255
L DQ AL+W+++N+ AFGG+PK VT+FG AGA+ VSL LS S LF +AI+QSG+
Sbjct: 224 LLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Query: 256 NAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLS 315
+ WAV Y+ T LA GC+ + T++++CL+NK+ +E++ Y
Sbjct: 284 LSSWAVN--YQPAKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQQTITPATY----H 337
Query: 316 VNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR 375
+ FGP +DGD + D P IL+E G+F I++GVN+ EG F+ DN +T
Sbjct: 338 IAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTP 392
Query: 376 KEFQEGLKIF------FPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICP 429
+F + F +P + +E+I F YTDW D + PE R+ L + D+ ++ P
Sbjct: 393 NDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAP 452
Query: 430 ALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NY 484
A+ +++G+ +FY F H P W HG E+ +VFG+P+ N+
Sbjct: 453 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNF 512
Query: 485 TKAEEILSRSIVKRWANFAKYGNPNETQNNST-------------SWPVFKSTEQKYLTL 531
+K + +LS ++ W NFAK G+PN+ T +W + +Q YL +
Sbjct: 513 SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHI 572
Query: 532 NTESTRIMTKLRAQQCRFWTSFFP 555
+ R+ RA + FW P
Sbjct: 573 GLK-PRVRDHYRATKVAFWLELVP 595
>gi|30840978 neuroligin 2 [Homo sapiens]
Length = 835
Score = 312 bits (800), Expect = 5e-85
Identities = 194/577 (33%), Positives = 293/577 (50%), Gaps = 67/577 (11%)
Query: 33 IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKY 89
++ T G+VRG+ + G V FLG+PYA PPLG RF+ P++ W + NAT
Sbjct: 43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 102
Query: 90 ANSCCQNIDQSFPGFHGSEMWNPNTDL--------SEDCLYLNVWIPAPK---------- 131
+C QN+ + P + N + SEDCLYLN+++P
Sbjct: 103 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEA 162
Query: 132 -----------PKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG 180
P V+++++GG + GT ++ +DG LA VIV ++NYR+G LG
Sbjct: 163 TLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNM--FDGSVLAAYGNVIVATLNYRLGVLG 220
Query: 181 FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG 240
FL+ G+ A GN GL DQ AL+W+ +NIA FGG+P+ +T+FG AGA+ V+L +LS
Sbjct: 221 FLST-GDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHH 279
Query: 241 SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI 300
S LF +AI QSG+ + W+V Y+ T LA GC RE+ E ++CLR K +E+
Sbjct: 280 SEGLFQKAIAQSGTAISSWSVN--YQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSREL 337
Query: 301 LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY 360
+ + Y + FGP VDGD + D P+IL++ G+F +L+GVN+ EG F+
Sbjct: 338 VDQDVQPARY----HIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVED 393
Query: 361 GAPGFSKDNNSI----ITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREA 416
A S+D S T F + L +P + +E+I F YTDW D E R+
Sbjct: 394 SAE--SEDGVSASAFDFTVSNFVDNL-YGYPEGKDVLRETIKFMYTDWADRDNGEMRRKT 450
Query: 417 LGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGL 476
L + D+ ++ PA+ K +++ + +FY F H PEW HG E+ +VFG+
Sbjct: 451 LLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGV 510
Query: 477 PLERRD-----NYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTS-------------W 518
P+ N++K + +LS ++ W NFAK G+PN+ T W
Sbjct: 511 PMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVW 570
Query: 519 PVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFP 555
F S E++YL + + R+ RA + FW P
Sbjct: 571 SKFNSKEKQYLHIGLK-PRVRDNYRANKVAFWLELVP 606
>gi|51593088 neuroligin 3 [Homo sapiens]
Length = 828
Score = 306 bits (785), Expect = 3e-83
Identities = 201/606 (33%), Positives = 299/606 (49%), Gaps = 78/606 (12%)
Query: 15 WFLLLCMLIGKSHTEDDI-IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLR 70
WFL L + ++ T+ + T GK+RG + + G V +LG+PYA PP+G R
Sbjct: 27 WFLSLAL---RASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKR 83
Query: 71 FKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDL--------SEDCLY 122
F P+ WS I NAT + C QNI + P + N D+ +EDCLY
Sbjct: 84 FLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLY 143
Query: 123 LNVWIPAPKPKNAT------------------------VLIWIYGGGFQTGTSSLHVYDG 158
LNV++P A V+++I+GG + GT ++ DG
Sbjct: 144 LNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM--IDG 201
Query: 159 KFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPK 218
LA VIV+++NYRVG LGFL+ G+ A GN GL DQ AL+WV +NIA FGG+P+
Sbjct: 202 SILASYGNVIVITLNYRVGVLGFLST-GDQAAKGNYGLLDQIQALRWVSENIAFFGGDPR 260
Query: 219 SVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLT 278
+T+FG GA+ VSL LS S LF RAI+QSGS + WAV Y+ T LA
Sbjct: 261 RITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVN--YQPVKYTSLLADKV 318
Query: 279 GCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELG 338
GC+ + +++ CLR K +E++ + Y V FGP +DGD + D P+IL+E G
Sbjct: 319 GCNVLDTVDMVDCLRQKSAKELVEQDIQPARY----HVAFGPVIDGDVIPDDPEILMEQG 374
Query: 339 QFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIF------FPGVSEF 392
+F I++GVN+ EG F V G D ++ +F + F +P +
Sbjct: 375 EFLNYDIMLGVNQGEGLKF-VEGV----VDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDT 429
Query: 393 GKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHR 452
+E+I F YTDW D PE R+ L + D+ ++ P++ + +G+ +FY F H
Sbjct: 430 LRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHH 489
Query: 453 SSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NYTKAEEILSRSIVKRWANFAKYGN 507
L P W HG E+ +VFG+P+ N++K + +LS ++ W NFAK G+
Sbjct: 490 CQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGD 549
Query: 508 PNETQNNST-------------SWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFF 554
PN+ T +W + +Q YL + + R+ RA + FW
Sbjct: 550 PNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLK-PRVRDHYRATKVAFWKHLV 608
Query: 555 PKVLEM 560
P + +
Sbjct: 609 PHLYNL 614
>gi|7662470 neuroligin 1 [Homo sapiens]
Length = 823
Score = 303 bits (777), Expect = 2e-82
Identities = 200/602 (33%), Positives = 299/602 (49%), Gaps = 82/602 (13%)
Query: 17 LLLCML---------IGKSHTEDDIIIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQP 64
L LCML + + + D ++AT GK+RG+ + G V FLG+PYA P
Sbjct: 29 LTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAP 88
Query: 65 PLGRLRFKKPQSLTKWSDIWNATKYANSCCQNI-DQSFPGFHGSEMWNPNTDL------- 116
P G RF+ P+ + WSDI NAT++A C QNI D P + N D+
Sbjct: 89 PTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQD 148
Query: 117 -SEDCLYLNVWIPA---------PKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVER 166
SEDCLYLN+++P PKP V+++I+GG + GT +L YDG LA
Sbjct: 149 QSEDCLYLNIYVPTEDDIRDSGGPKP----VMVYIHGGSYMEGTGNL--YDGSVLASYGN 202
Query: 167 VIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGES 226
VIV+++NYR+G LGFL+ G+ A GN GL D AL+W +NI FGG+P +T+FG
Sbjct: 203 VIVITVNYRLGVLGFLST-GDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSG 261
Query: 227 AGAASVSLHLLSPGSHS---------LFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKL 277
AG + V+L LS S LF RAI QSG+ + WAV+ ++ LA
Sbjct: 262 AGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVS--FQPAKYARMLATK 319
Query: 278 TGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLEL 337
GC+ + E+++CL+ K +E++ + Y + FGP +DGD + D P IL+E
Sbjct: 320 VGCNVSDTVELVECLQKKPYKELVDQDIQPARY----HIAFGPVIDGDVIPDDPQILMEQ 375
Query: 338 GQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIF------FPGVSE 391
G+F I++GVN+ EG F+ D++ I+ +F + F +P +
Sbjct: 376 GEFLNYDIMLGVNQGEGLKFVENIV-----DSDDGISASDFDFAVSNFVDNLYGYPEGKD 430
Query: 392 FGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEH 451
+E+I F YTDW D PE R+ L + D+ ++ PA+ S +G+ +FY F H
Sbjct: 431 VLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYH 490
Query: 452 RSSKLPWPEWMGVMHGYEIEFVFGLPLERRD-----NYTKAEEILSRSIVKRWANFAKYG 506
P W HG E+ +V G+P+ N++K + +LS ++ W NFAK G
Sbjct: 491 HCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTG 550
Query: 507 NPNETQNNST-------------SWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSF 553
+PN+ T +W + +Q YL + + R+ RA + W
Sbjct: 551 DPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLK-PRVKEHYRANKVNLWLEL 609
Query: 554 FP 555
P
Sbjct: 610 VP 611
>gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens]
Length = 575
Score = 281 bits (720), Expect = 9e-76
Identities = 192/535 (35%), Positives = 273/535 (51%), Gaps = 34/535 (6%)
Query: 36 TKNGKVRGMNLTVFGGTV--TAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSC 93
T+ G ++G +TV G V FLG+P+A PPLG LRF PQ + W ++ AT Y N C
Sbjct: 35 TRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLC 94
Query: 94 CQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNA--TVLIWIYGGGFQTGTS 151
QN + H ++ P +SEDCLYLN++ PA + VL+W GG F+TG++
Sbjct: 95 LQNSEWLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSA 154
Query: 152 SLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIA 211
S ++DG LA E V+VV + YR+G GF + APGN DQ AL WVQKNI
Sbjct: 155 S--IFDGSALAAYEDVLVVVVQYRLGIFGFFT-TWDQHAPGNWAFKDQVAALSWVQKNIE 211
Query: 212 AFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRT 271
FGG+P SVT+FGESAGA SVS +LSP + LF +AI++SG P+ YE
Sbjct: 212 FFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDL 271
Query: 272 LNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMP 331
+A G + + +++CLR K +E+L + + +F VDG F + P
Sbjct: 272 QVVAHFCGNNASDSEALLRCLRTKPSKELLTL--------SQKTKSFTRVVDGAFFPNEP 323
Query: 332 DILLELGQFKKTQILVGVNKDE-GTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVS 390
LL FK ++GVN E G + AP +N + Q L I +
Sbjct: 324 LDLLSQKAFKAIPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYLH 383
Query: 391 EFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFE 450
E FH D R++L D++GD F+ PAL + + G +FY F
Sbjct: 384 LVANE--YFH-----DKHSLTEIRDSLLDLLGDVFFVVPALITARYHRDAGAPVYFYEFR 436
Query: 451 HRSS--KLPWPEWMGVMHGYEIEFVFGLPLERRD-----NYTKAEEILSRSIVKRWANFA 503
HR + P ++ H E+ FVFG + D T+ E++LSR ++K WA FA
Sbjct: 437 HRPQCFEDTKPAFVKADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFA 496
Query: 504 KYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVL 558
+ GNPN N+ + WP + TEQ YL L+ + + +L+ + FWTS P +L
Sbjct: 497 RTGNPN--GNDLSLWPAYNLTEQ-YLQLDLNMS-LGQRLKEPRVDFWTSTIPLIL 547
>gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens]
Length = 623
Score = 267 bits (683), Expect = 2e-71
Identities = 196/567 (34%), Positives = 285/567 (50%), Gaps = 38/567 (6%)
Query: 17 LLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGT--VTAFLGIPYAQPPLGRLRFKKP 74
LLL ++ G+ I T G+V G + V G V FLGIP+A+PPLG LRF P
Sbjct: 81 LLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPP 140
Query: 75 QSLTKWSDIWNATKYANSCCQNIDQSFPGFHGS-EMWNPNTDLSEDCLYLNVWIPAPKPK 133
+ WS + + T + C Q++ F M P+ +SEDCLYL+++ PA +
Sbjct: 141 EPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHE 200
Query: 134 --NATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191
N V++WI+GG G +SL YDG LA +E V+VV + YR+G LGF + G+ A
Sbjct: 201 GSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVLGFFST-GDKHAT 257
Query: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251
GN G DQ AL+WVQ+NIA FGGNP VT+FGESAG SVS ++SP S LF AI++
Sbjct: 258 GNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIME 317
Query: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEIL-LNEAFVVPY 310
SG P + S + + +A L+ C + + ++ CLR K +EIL +N+ F +
Sbjct: 318 SGVALLPGLIASSADVISTV--VANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIP 375
Query: 311 GTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFL--VYGAPGFSKD 368
G VDG FL P LL F+ +VGVN +E + V K+
Sbjct: 376 G---------VVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKE 426
Query: 369 NNSIITRKEFQEGLKIFF--PGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNF 426
+ ++ Q+ L + P + +E + D+ P+ + +++ D F
Sbjct: 427 MDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNGDPQTLQAQFQEMMADSMF 480
Query: 427 ICPALEFTKKFSEWGNNAFFYYFEHRSSKLP--WPEWMGVMHGYEIEFVF-GLPLERRDN 483
+ PAL+ F +FY F+H+ S L P M HG E+ FVF
Sbjct: 481 VIPALQ-VAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIK 539
Query: 484 YTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLR 543
+T+ EE LSR ++K WANFA+ GNPN WP+F EQ YL LN + + L+
Sbjct: 540 FTEEEEQLSRKMMKYWANFARNGNPN--GEGLPHWPLFDQEEQ-YLQLNLQPA-VGRALK 595
Query: 544 AQQCRFWTSFFPKVLEMTGNIDEAEWE 570
A + +FW P+ ++ +E E
Sbjct: 596 AHRLQFWKKALPQKIQELEEPEERHTE 622
>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
Length = 756
Score = 261 bits (667), Expect = 1e-69
Identities = 178/542 (32%), Positives = 266/542 (49%), Gaps = 48/542 (8%)
Query: 34 IATKNGKVRGMN--LTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYAN 91
+ T+ G V G+N L + G +V F GIP+A P + PQ W A +
Sbjct: 29 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAKNFKK 85
Query: 92 SCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP---KNATVLIWIYGGGFQT 148
C Q + + +T EDCLYLN+W+P + ++ V+IWIYGG F
Sbjct: 86 RCLQ-----------ATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLM 134
Query: 149 GTS------SLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLA 202
G+ + ++YDG+ +A VIVV+ NYRVG LGFL+ G+ PGN GL DQ +A
Sbjct: 135 GSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLST-GDANLPGNYGLRDQHMA 193
Query: 203 LQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAV- 261
+ WV++NIAAFGG+P ++TLFGESAG ASVSL LSP + L RAI QSG +PW +
Sbjct: 194 IAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQ 253
Query: 262 -TSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVP-----YGTPLS 315
L+ A+ +A+ GC + + +CL+ DP+ + L A+ VP Y
Sbjct: 254 KNPLFWAK----KVAEKVGCPVGDAARMAQCLKVTDPRALTL--AYKVPLAGLEYPMLHY 307
Query: 316 VNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR 375
V F P +DGDF+ P L + G N +G F P +K N +T
Sbjct: 308 VGFVPVIDGDFIPADPINL--YANAADIDYIAGTNNMDGHIFASIDMPAINKGNKK-VTE 364
Query: 376 KEFQEGLKIFFPGVSEFGKESILFHYTD-WVDDQRPENYREALGDVVGDYNFICPALEFT 434
++F + + F G ++ YT+ W D EN ++ + D D F+ P
Sbjct: 365 EDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIAL 424
Query: 435 KKFSEWGNNA--FFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILS 492
+ +A + Y F H S +P+W+G H +I++VFG P Y + +S
Sbjct: 425 AQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVS 484
Query: 493 RSIVKRWANFAKYGNPNETQNN-STSWPVFKSTEQKYLTLNTE--STRIMTKLRAQQCRF 549
++++ W NFAK G+PN + T W + + YL + + S+ + LR R+
Sbjct: 485 KAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRY 544
Query: 550 WT 551
WT
Sbjct: 545 WT 546
>gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens]
Length = 607
Score = 258 bits (660), Expect = 8e-69
Identities = 190/566 (33%), Positives = 282/566 (49%), Gaps = 52/566 (9%)
Query: 17 LLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGT--VTAFLGIPYAQPPLGRLRFKKP 74
LLL ++ G+ I T G+V G + V G V FLGIP+A+PPLG LRF P
Sbjct: 81 LLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPP 140
Query: 75 QSLTKWSDIWNATKYANSCCQNIDQSFPGFHGS-EMWNPNTDLSEDCLYLNVWIPAPKPK 133
+ WS + + T + C Q++ F M P+ +SEDCLYL+++ PA +
Sbjct: 141 EPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHE 200
Query: 134 --NATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191
N V++WI+GG G +SL YDG LA +E V+VV + YR+G LGF + G+ A
Sbjct: 201 GSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVLGFFST-GDKHAT 257
Query: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251
GN G DQ AL+WVQ+NIA FGGNP VT+FGESAG SVS ++SP S LF AI++
Sbjct: 258 GNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIME 317
Query: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEIL-LNEAFVVPY 310
SG P + S + + +A L+ C + + ++ CLR K +EIL +N+ F +
Sbjct: 318 SGVALLPGLIASSADVISTV--VANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIP 375
Query: 311 GTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFL--VYGAPGFSKD 368
G VDG FL P LL F+ +VGVN +E + V K+
Sbjct: 376 G---------VVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKE 426
Query: 369 NNSIITRKEFQEGLKIFF--PGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNF 426
+ ++ Q+ L + P + +E + D+ P+ + +++ D F
Sbjct: 427 MDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNGDPQTLQAQFQEMMADSMF 480
Query: 427 ICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDN--Y 484
+ PAL+ F +FY F+H+ P W+ + P + D+ +
Sbjct: 481 VIPALQ-VAHFQCSRAPVYFYEFQHQ------PSWLKNIRP---------PHMKADHVKF 524
Query: 485 TKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRA 544
T+ EE LSR ++K WANFA+ GNPN WP+F EQ YL LN + + L+A
Sbjct: 525 TEEEEQLSRKMMKYWANFARNGNPN--GEGLPHWPLFDQEEQ-YLQLNLQPA-VGRALKA 580
Query: 545 QQCRFWTSFFPKVLEMTGNIDEAEWE 570
+ +FW P+ ++ +E E
Sbjct: 581 HRLQFWKKALPQKIQELEEPEERHTE 606
>gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens]
Length = 525
Score = 253 bits (645), Expect = 5e-67
Identities = 180/528 (34%), Positives = 256/528 (48%), Gaps = 70/528 (13%)
Query: 36 TKNGKVRGMNLTVFGGTV--TAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSC 93
T+ G ++G +TV G V FLG+P+A PPLG LRF PQ + W ++ AT Y N C
Sbjct: 35 TRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLC 94
Query: 94 CQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNA--TVLIWIYGGGFQTGTS 151
QN + H ++ P +SEDCLYLN++ PA + VL+W GG F+TG++
Sbjct: 95 LQNSEWLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSA 154
Query: 152 SLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIA 211
S ++DG LA E V+VV + YR+G GF + APGN DQ AL WVQKNI
Sbjct: 155 S--IFDGSALAAYEDVLVVVVQYRLGIFGFFT-TWDQHAPGNWAFKDQVAALSWVQKNIE 211
Query: 212 AFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRT 271
FGG+P SVT+FGESAGA SVS +LSP + LF +AI++SG P+ YE
Sbjct: 212 FFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDL 271
Query: 272 LNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMP 331
+A G + + +++CLR K +E+L + + +F VDG F + P
Sbjct: 272 QVVAHFCGNNASDSEALLRCLRTKPSKELLTL--------SQKTKSFTRVVDGAFFPNEP 323
Query: 332 DILLELGQFKKTQILVGVNKDE-GTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVS 390
LL FK ++GVN E G + AP +N + Q L I +
Sbjct: 324 LDLLSQKAFKAIPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYLH 383
Query: 391 EFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFE 450
E FH D R++L D++GD F+ PAL T ++
Sbjct: 384 LVANE--YFH-----DKHSLTEIRDSLLDLLGDVFFVVPAL-ITARY------------- 422
Query: 451 HRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNE 510
R+ T+ E++LSR ++K WA FA+ GNPN
Sbjct: 423 -----------------------------HREGATEEEKLLSRKMMKYWATFARTGNPN- 452
Query: 511 TQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVL 558
N+ + WP + TEQ YL L+ + + +L+ + FWTS P +L
Sbjct: 453 -GNDLSLWPAYNLTEQ-YLQLDLNMS-LGQRLKEPRVDFWTSTIPLIL 497
>gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens]
Length = 568
Score = 249 bits (637), Expect = 4e-66
Identities = 192/553 (34%), Positives = 273/553 (49%), Gaps = 41/553 (7%)
Query: 27 HTEDDIIIATKNGKVRG--MNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIW 84
H ++ T +GKV G ++L F V FLGIP+A+PPLG LRF PQ WS +
Sbjct: 20 HPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVK 79
Query: 85 NATKYANSCCQN--IDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP--KPKNATVLIW 140
NAT Y C Q+ Q + N LSEDCLYLN++ PA K V++W
Sbjct: 80 NATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVW 139
Query: 141 IYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQ 200
I+GGG G +S YDG LA E V+VV++ YR+G GF + G+ + GN G DQ
Sbjct: 140 IHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNWGHLDQV 196
Query: 201 LALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWA 260
AL+WVQ NIA+FGGNP SVT+FGESAG SVS+ +LSP + +LF RAI +SG A
Sbjct: 197 AALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV-----A 251
Query: 261 VTSLYEARNRTLNLAK----LTGCSRENETEIIKCLRNKDPQEIL---LNEAFVV--PYG 311
+TS+ + LA+ GC ++ CLR K +E+L L F+ G
Sbjct: 252 LTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQG 311
Query: 312 TPLSVN--FGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDN 369
P G +DG L P+ L F +VG+NK E + +
Sbjct: 312 DPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSE 371
Query: 370 NSIITRKEFQEGLKIFFPGVSEFGKESI---LFHYTDWVDDQRPENYREALGDVVGDYNF 426
+ +K L +P V KE I Y DD + ++ D++ D F
Sbjct: 372 GQ-LDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKK--KDLFLDLIADVMF 427
Query: 427 ICPALEFTKKFSEWGNNAFFYYFEHR---SSKLPWPEWMGVMHGYEIEFVFGLPLERRDN 483
P++ + + G + Y F++R SS + P+ + HG E+ VFG P ++
Sbjct: 428 GVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMK-PKTVIGDHGDELFSVFGAPF-LKEG 485
Query: 484 YTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLR 543
++ E LS+ ++K WANFA+ GNPN WP + E YL + +T+ KL+
Sbjct: 486 ASEEEIRLSKMVMKFWANFARNGNPN--GEGLPHWPEYNQKE-GYLQIGA-NTQAAQKLK 541
Query: 544 AQQCRFWTSFFPK 556
++ FWT+ F K
Sbjct: 542 DKEVAFWTNLFAK 554
>gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens]
Length = 567
Score = 249 bits (637), Expect = 4e-66
Identities = 192/553 (34%), Positives = 273/553 (49%), Gaps = 41/553 (7%)
Query: 27 HTEDDIIIATKNGKVRG--MNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIW 84
H ++ T +GKV G ++L F V FLGIP+A+PPLG LRF PQ WS +
Sbjct: 19 HPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVK 78
Query: 85 NATKYANSCCQN--IDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP--KPKNATVLIW 140
NAT Y C Q+ Q + N LSEDCLYLN++ PA K V++W
Sbjct: 79 NATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVW 138
Query: 141 IYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQ 200
I+GGG G +S YDG LA E V+VV++ YR+G GF + G+ + GN G DQ
Sbjct: 139 IHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNWGHLDQV 195
Query: 201 LALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWA 260
AL+WVQ NIA+FGGNP SVT+FGESAG SVS+ +LSP + +LF RAI +SG A
Sbjct: 196 AALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV-----A 250
Query: 261 VTSLYEARNRTLNLAK----LTGCSRENETEIIKCLRNKDPQEIL---LNEAFVV--PYG 311
+TS+ + LA+ GC ++ CLR K +E+L L F+ G
Sbjct: 251 LTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQG 310
Query: 312 TPLSVN--FGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDN 369
P G +DG L P+ L F +VG+NK E + +
Sbjct: 311 DPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSE 370
Query: 370 NSIITRKEFQEGLKIFFPGVSEFGKESI---LFHYTDWVDDQRPENYREALGDVVGDYNF 426
+ +K L +P V KE I Y DD + ++ D++ D F
Sbjct: 371 GQ-LDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKK--KDLFLDLIADVMF 426
Query: 427 ICPALEFTKKFSEWGNNAFFYYFEHR---SSKLPWPEWMGVMHGYEIEFVFGLPLERRDN 483
P++ + + G + Y F++R SS + P+ + HG E+ VFG P ++
Sbjct: 427 GVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMK-PKTVIGDHGDELFSVFGAPF-LKEG 484
Query: 484 YTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLR 543
++ E LS+ ++K WANFA+ GNPN WP + E YL + +T+ KL+
Sbjct: 485 ASEEEIRLSKMVMKFWANFARNGNPN--GEGLPHWPEYNQKE-GYLQIGA-NTQAAQKLK 540
Query: 544 AQQCRFWTSFFPK 556
++ FWT+ F K
Sbjct: 541 DKEVAFWTNLFAK 553
>gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens]
Length = 566
Score = 249 bits (636), Expect = 5e-66
Identities = 193/553 (34%), Positives = 275/553 (49%), Gaps = 42/553 (7%)
Query: 27 HTEDDIIIATKNGKVRG--MNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIW 84
H ++ T +GKV G ++L F V FLGIP+A+PPLG LRF PQ WS +
Sbjct: 19 HPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVK 78
Query: 85 NATKYANSCCQN--IDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP--KPKNATVLIW 140
NAT Y C Q+ Q + N LSEDCLYLN++ PA K V++W
Sbjct: 79 NATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVW 138
Query: 141 IYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQ 200
I+GGG G +S YDG LA E V+VV++ YR+G GF + G+ + GN G DQ
Sbjct: 139 IHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNWGHLDQV 195
Query: 201 LALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWA 260
AL+WVQ NIA+FGGNP SVT+FGESAG SVS+ +LSP + +LF RAI +SG A
Sbjct: 196 AALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV-----A 250
Query: 261 VTSLYEARNRTLNLAK----LTGCSRENETEIIKCLRNKDPQEIL---LNEAFVV--PYG 311
+TS+ + LA+ GC ++ CLR K +E+L L F+ G
Sbjct: 251 LTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQG 310
Query: 312 TPLSVN--FGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDN 369
P G +DG L P+ L F +VG+NK E +L+ +
Sbjct: 311 DPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQE-FGWLIPMLMSYPLSE 369
Query: 370 NSIITRKEFQEGLKIFFPGVSEFGKESI---LFHYTDWVDDQRPENYREALGDVVGDYNF 426
+ +K L +P V KE I Y DD + ++ D++ D F
Sbjct: 370 GQ-LDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKK--KDLFLDLIADVMF 425
Query: 427 ICPALEFTKKFSEWGNNAFFYYFEHR---SSKLPWPEWMGVMHGYEIEFVFGLPLERRDN 483
P++ + + G + Y F++R SS + P+ + HG E+ VFG P ++
Sbjct: 426 GVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMK-PKTVIGDHGDELFSVFGAPF-LKEG 483
Query: 484 YTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLR 543
++ E LS+ ++K WANFA+ GNPN WP + E YL + +T+ KL+
Sbjct: 484 ASEEEIRLSKMVMKFWANFARNGNPN--GEGLPHWPEYNQKE-GYLQIGA-NTQAAQKLK 539
Query: 544 AQQCRFWTSFFPK 556
++ FWT+ F K
Sbjct: 540 DKEVAFWTNLFAK 552
>gi|33563374 carboxylesterase 3 [Homo sapiens]
Length = 571
Score = 235 bits (599), Expect = 1e-61
Identities = 174/544 (31%), Positives = 264/544 (48%), Gaps = 41/544 (7%)
Query: 34 IATKNGKVRGMNLTVFGGT--VTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYAN 91
+ T G+VRG + V G V FLGIP+AQPPLG RF P W + +A+
Sbjct: 36 VDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPP 95
Query: 92 SCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNA--TVLIWIYGGGFQTG 149
C Q+++ +SEDCL LNV+ PA P + V++W++GG TG
Sbjct: 96 MCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITG 155
Query: 150 TSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKN 209
++ YDG LA V+VV++ YR+G LGF + G+ APGN G D AL+WVQ+N
Sbjct: 156 AATS--YDGSALAAYGDVVVVTVQYRLGVLGFFST-GDEHAPGNQGFLDVVAALRWVQEN 212
Query: 210 IAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARN 269
IA FGG+ VT+FG SAG + +S +LSP + LF RAI QSG P + S
Sbjct: 213 IAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDS--HPWP 270
Query: 270 RTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTD 329
+A CS + E+++CL+ K+ +E++L++ + + TVDG
Sbjct: 271 LAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKL-------KNTIYPLTVDGTVFPK 323
Query: 330 MPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGV 389
P LL+ F L+GVN E ++L+ G D ++R++ L I P +
Sbjct: 324 SPKELLKEKPFHSVPFLMGVNNHE-FSWLIPRGWGL-LDTMEQMSREDM---LAISTPVL 378
Query: 390 SEFG-----KESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNA 444
+ +++ Y D + + +A + +GD P + F++ + G+
Sbjct: 379 TSLDVPPEMMPTVIDEYLGSNSDAQAK--CQAFQEFMGDVFINVPTVSFSRYLRDSGSPV 436
Query: 445 FFYYFEHRSSKLP--WPEWMGVMHGYEIEFVFGLPLERRDN-------YTKAEEILSRSI 495
FFY F+HR S P W+ HG E FVFG P ++ T+ E+ LS ++
Sbjct: 437 FFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTM 496
Query: 496 VKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFP 555
+ +W +FA+ G+PN WP F EQ YL +N R K R +FW+ P
Sbjct: 497 MAQWTHFARTGDPN--SKALPPWPQFNQAEQ-YLEIN-PVPRAGQKFREAWMQFWSETLP 552
Query: 556 KVLE 559
++
Sbjct: 553 SKIQ 556
>gi|115529439 carboxylesterase 8 (putative) [Homo sapiens]
Length = 491
Score = 222 bits (566), Expect = 7e-58
Identities = 178/570 (31%), Positives = 264/570 (46%), Gaps = 122/570 (21%)
Query: 13 LFWFLLLCML----IGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGR 68
L W L LC++ +G HT+ ++ TK G ++G + V + FLG+P+++PPLG
Sbjct: 5 LCWSLTLCLMAQTALGALHTKRPQVV-TKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGI 63
Query: 69 LRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPN-TDLSEDCLYLNVWI 127
LRF P+ W I +AT Y C Q + S SEDCLYLNV+
Sbjct: 64 LRFAPPEPPEPWKGIRDATTYPPGCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVYA 123
Query: 128 PAPKPKNAT--VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALP 185
PA P + V++W GG F G +S Y+G LA E+V++V + +R+G GFL+
Sbjct: 124 PARAPGDPQLPVMVWFPGGAFIVGAASS--YEGSDLAAREKVVLVFLQHRLGIFGFLSTD 181
Query: 186 GNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLF 245
+ A GN GL DQ AL+WVQ+NIAAFGG+P +VTLFG+SAGA S+S ++SP + LF
Sbjct: 182 DS-HARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLF 240
Query: 246 TRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLR------------ 293
RAI QSG+ +TS +A L GC+ + ++ CLR
Sbjct: 241 HRAISQSGTALFRLFITS--NPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSN 298
Query: 294 ---------NKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQ 344
+DP+EI+ + P VDG + D P +LL G+
Sbjct: 299 KMRFLQLNFQRDPEEIIW--------------SMSPVVDGVVIPDDPLVLLTQGKVSSVP 344
Query: 345 ILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDW 404
L+GVN E L Y IT+++ ++ + V+E DW
Sbjct: 345 YLLGVNNLEFNWLLPYN-----------ITKEQVPLVVEEYLDNVNEH----------DW 383
Query: 405 VDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGV 464
+ R + D+V D F+ L+ +Y HR
Sbjct: 384 ------KMLRNRMMDIVQDATFVYATLQTA------------HY--HR------------ 411
Query: 465 MHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKST 524
GL + + E+ LS ++K WANFA+ GNPN+ N WP + +
Sbjct: 412 ----------GLSMGK-------EKALSLQMMKYWANFARTGNPND--GNLPCWPRY-NK 451
Query: 525 EQKYLTLNTESTRIMTKLRAQQCRFWTSFF 554
++KYL L+ +TR+ KL+ ++ FW S +
Sbjct: 452 DEKYLQLDF-TTRVGMKLKEKKMAFWMSLY 480
>gi|55770862 thyroglobulin [Homo sapiens]
Length = 2768
Score = 220 bits (560), Expect = 3e-57
Identities = 161/540 (29%), Positives = 256/540 (47%), Gaps = 48/540 (8%)
Query: 38 NGKVRGMNLTVFGGT----VTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSC 93
+G++ G + + GT V FLG+PYA PPL RF+ P+ L W+ W+A+K SC
Sbjct: 2206 HGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASC 2264
Query: 94 CQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSL 153
Q PG S + +SEDCLYLNV+IP NA+VL++ + + +
Sbjct: 2265 WQ------PGTRTST----SPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGW 2314
Query: 154 HVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAF 213
DG FLA V +IVV+ +YRVG GFL+ G+ E GN GL DQ AL WVQ +I F
Sbjct: 2315 PAIDGSFLAAVGNLIVVTASYRVGVFGFLS-SGSGEVSGNWGLLDQVAALTWVQTHIRGF 2373
Query: 214 GGNPKSVTLFGESAGAASVSLHLLS--PGSHSLFTRAILQSGSFNAPWAVTSLYEARNRT 271
GG+P+ V+L + GA S+HLL+ + LF RA+L GS +P AV S A+ +
Sbjct: 2374 GGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQA 2433
Query: 272 LNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMP 331
+ LAK C + E++ CLR K + + ++ P +GP +DG FL + P
Sbjct: 2434 IALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHY-WGPVIDGHFLREPP 2492
Query: 332 DILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSE 391
L+ + + +L+G ++D+G F + ++ F + L+ G
Sbjct: 2493 ARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDS 2552
Query: 392 FGK--ESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYF 449
+ + ++Y+ ++ AL + DY ICP ++ +++ F Y
Sbjct: 2553 DARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYH 2612
Query: 450 EHRSSKLPWPEWMGVMHG-----YEIEFVFGLPL--ERRDNYTKAEEILSRSIVKRWANF 502
PE G HG +++F GLP ++ E+ LS I++ +++F
Sbjct: 2613 A--------PENYG--HGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHF 2662
Query: 503 AKYGNPN-------ETQNNSTSWPVF--KSTEQKYLTLNTESTRIMTKLRAQQCRFWTSF 553
+ GNPN + +T WP F ++ + Y +E L+ C FW+ +
Sbjct: 2663 IRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEF-SELLPNRQGLKKADCSFWSKY 2721
>gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens]
Length = 327
Score = 132 bits (331), Expect = 1e-30
Identities = 99/290 (34%), Positives = 140/290 (48%), Gaps = 19/290 (6%)
Query: 143 GGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLA 202
GG F+TG++S ++DG LA E ++VV + YR+G GF + APGN DQ A
Sbjct: 20 GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFT-TWDQHAPGNWAFKDQVAA 76
Query: 203 LQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVT 262
L WVQKNI FGG+P SVT+FGES GA SVS +LSP + LF +A+++SG +
Sbjct: 77 LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLMLSPMAEGLFHKAVMESGVAIILYLKA 136
Query: 263 SLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTV 322
YE +A+ G + + ++CLR K +E+L + + F V
Sbjct: 137 HDYEKSEDLQVVAQFCGYNASDSEAPLRCLRTKSSKELLTL--------SQKTKAFTQVV 188
Query: 323 DGDFLTDMPDILLELGQFKKTQILVGVNKDE-GTAFLVYGAPGFSKDNNSIITRKEFQEG 381
DG F + P LL FK ++GVN E G + AP +N + Q
Sbjct: 189 DGAFFPNEPLDLLSQKAFKAIPSIIGVNNPECGFPLPMKEAPEILSGSNKSLALCLTQNI 248
Query: 382 LKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPAL 431
L I + E FH D R++L D++GD F+ P L
Sbjct: 249 LHILPNYLHLVAGE--YFH-----DKHSLTEIRDSLLDLLGDVFFVIPKL 291
>gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens]
Length = 327
Score = 132 bits (331), Expect = 1e-30
Identities = 99/290 (34%), Positives = 140/290 (48%), Gaps = 19/290 (6%)
Query: 143 GGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLA 202
GG F+TG++S ++DG LA E ++VV + YR+G GF + APGN DQ A
Sbjct: 20 GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFT-TWDQHAPGNWAFKDQVAA 76
Query: 203 LQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVT 262
L WVQKNI FGG+P SVT+FGES GA SVS +LSP + LF +A+++SG +
Sbjct: 77 LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLILSPMAEGLFHKAVMESGVAIILYLKA 136
Query: 263 SLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTV 322
YE +A+ G + + ++CLR K +E+L + + F V
Sbjct: 137 HDYEKSEDLQVVAQFCGYNASDSEAPLRCLRTKSSKELLTL--------SQKTKAFTQVV 188
Query: 323 DGDFLTDMPDILLELGQFKKTQILVGVNKDE-GTAFLVYGAPGFSKDNNSIITRKEFQEG 381
DG F + P LL FK ++GVN E G + AP +N + Q
Sbjct: 189 DGAFFPNEPLDLLSQKAFKAIPSIIGVNNPECGFPLPMKEAPEILSGSNKSLALCLTQNI 248
Query: 382 LKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPAL 431
L I + E FH D R++L D++GD F+ P L
Sbjct: 249 LHILPNYLHLVAGE--YFH-----DKHSLTEIRDSLLDLLGDVFFVIPKL 291
>gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens]
Length = 131
Score = 84.0 bits (206), Expect = 4e-16
Identities = 43/87 (49%), Positives = 56/87 (64%), Gaps = 3/87 (3%)
Query: 137 VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGL 196
VL+W GG F+TG++S ++DG LA E ++VV + YR+G GF + APGN
Sbjct: 20 VLLWFPGGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPGNWAF 76
Query: 197 FDQQLALQWVQKNIAAFGGNPKSVTLF 223
DQ AL WVQKNI FGG+P SVT+F
Sbjct: 77 KDQVAALSWVQKNIEFFGGDPSSVTIF 103
>gi|68299767 arylacetamide deacetylase [Homo sapiens]
Length = 399
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/123 (31%), Positives = 64/123 (52%), Gaps = 20/123 (16%)
Query: 125 VWIPAPKPKNATV---LIWIYGGGFQTGTSSLHVYD--GKFLARVERVIVVSMNYRVGAL 179
V + PK K+ + L +I+GGG+ G+++L YD ++ A +VVS NYR+
Sbjct: 91 VRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLA-- 148
Query: 180 GFLALPGNPEAPGNMGLFDQQLALQWV--QKNIAAFGGNPKSVTLFGESAG---AASVSL 234
P+ + D AL+W +K +A +G NP+ + + G+SAG AA+V+
Sbjct: 149 --------PKYHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQ 200
Query: 235 HLL 237
LL
Sbjct: 201 QLL 203
>gi|21328446 hormone-sensitive lipase [Homo sapiens]
Length = 1076
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 11/107 (10%)
Query: 123 LNVWI-PAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGF 181
L +W P P++ ++++ +GGGF TS H K A+ ++S++Y +
Sbjct: 631 LELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLA---- 686
Query: 182 LALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAG 228
PEAP L + A W K+ A G + + L G+SAG
Sbjct: 687 ------PEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAG 727
>gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens]
Length = 401
Score = 33.9 bits (76), Expect = 0.44
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 130 PKPKNAT---VLIWIYGGGFQTGTSSLHVYD--GKFLARVERVIVVSMNYRVGALGFLAL 184
PK K+ T +I+ +GGGF G+S +D ++ A +VV ++YR LA
Sbjct: 96 PKRKSETRRRAVIYFHGGGFCFGSSKQRAFDFLNRWTANTLDAVVVGVDYR------LAP 149
Query: 185 PGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAG 228
+ A GL + L ++K + +G +P + + G+S+G
Sbjct: 150 QHHFPAQFEDGLAAVKFFL--LEKILTKYGVDPTRICIAGDSSG 191
>gi|68051721 arylacetamide deacetylase-like 1 isoform b [Homo
sapiens]
Length = 440
Score = 33.1 bits (74), Expect = 0.75
Identities = 19/67 (28%), Positives = 36/67 (53%), Gaps = 4/67 (5%)
Query: 114 TDLSEDCLYLNVWIPAPKPKNATV--LIWIYGGGFQTGTSSLHVYDGKFLARVERV--IV 169
TD D + + V+ PKP+ +++I+GGG+ ++ + YD A E + ++
Sbjct: 115 TDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVI 174
Query: 170 VSMNYRV 176
VS+ YR+
Sbjct: 175 VSIEYRL 181
>gi|21361933 integrin alpha FG-GAP repeat containing 1 [Homo
sapiens]
Length = 612
Score = 33.1 bits (74), Expect = 0.75
Identities = 24/108 (22%), Positives = 47/108 (43%), Gaps = 11/108 (10%)
Query: 322 VDGDF----LTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKE 377
+DG+F + + P ++ +GQ +G + + PG N T
Sbjct: 240 LDGNFSVSTILEKPQNMMVVGQSAFADF-------DGDGHMDHLLPGCEDKNCQKSTIYL 292
Query: 378 FQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYN 425
+ G+K + P + +F + L+ + +VD+Q+P + +GDYN
Sbjct: 293 VRSGMKQWVPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYN 340
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 23/144 (15%)
Query: 124 NVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLA 183
+V +P +P N +W+ G S+ + DG+ YRVG G L
Sbjct: 584 DVLLPCDQPSNLARALWLLNG-------SMGLSDGQG------------GYRVGVDGLLV 624
Query: 184 LPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHS 243
PE GN G + ++ L+ + +A++ + T A+ L+P
Sbjct: 625 TDAQPEHSGNYGCYAEENGLRTL---LASYSLTVRPATPAPAPKAPATPGAQ-LAPDVRL 680
Query: 244 LFTRAILQSGSFNAPWAVTSLYEA 267
L+ AI G A + LY A
Sbjct: 681 LYVLAIAALGGLCLILASSLLYVA 704
>gi|4502613 cyclin A [Homo sapiens]
Length = 432
Score = 31.6 bits (70), Expect = 2.2
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 402 TDWVDDQRPENYR-EALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPE 460
T + Q+P N + E+L +G+ + I A + K A F+ + + WPE
Sbjct: 316 TQYFLHQQPANCKVESLAMFLGELSLI-DADPYLKYLPSVIAGAAFHLALYTVTGQSWPE 374
Query: 461 WMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYG----NPNETQN 513
+ GY +E + ++ Y KA + +SI +++ N +G NP ET N
Sbjct: 375 SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLN 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,059,476
Number of Sequences: 37866
Number of extensions: 1085403
Number of successful extensions: 2577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2414
Number of HSP's gapped (non-prelim): 46
length of query: 602
length of database: 18,247,518
effective HSP length: 108
effective length of query: 494
effective length of database: 14,157,990
effective search space: 6994047060
effective search space used: 6994047060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.