Search of human proteins with 45383011

Search of human proteins with 45383011

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45383011 potassium voltage-gated channel, delayed-rectifier,
subfamily S, member 2 [Homo sapiens]
         (477 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   960   0.0  
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   513   e-145
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   467   e-132
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   379   e-105
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   375   e-104
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    346   2e-95
gi|20070166 potassium voltage-gated channel, subfamily F, member...   307   2e-83
gi|27436996 potassium voltage-gated channel, subfamily G, member...   290   2e-78
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]   290   3e-78
gi|27436988 potassium voltage-gated channel, subfamily G, member...   282   5e-76
gi|27436993 potassium voltage-gated channel, subfamily G, member...   260   2e-69
gi|19071574 potassium voltage-gated channel, subfamily G, member...   255   5e-68
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   254   1e-67
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   247   1e-65
gi|25952092 potassium voltage-gated channel, shaker-related subf...   239   5e-63
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   233   3e-61
gi|119395748 potassium voltage-gated channel subfamily A member ...   233   4e-61
gi|21217561 Shaw-related voltage-gated potassium channel protein...   229   3e-60
gi|21217563 Shaw-related voltage-gated potassium channel protein...   229   3e-60
gi|24497458 Shaw-related voltage-gated potassium channel protein...   229   3e-60
gi|88758565 potassium voltage-gated channel, shaker-related subf...   227   2e-59
gi|24497460 Shaw-related voltage-gated potassium channel protein...   225   8e-59
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   224   1e-58
gi|163792201 Shaw-related voltage-gated potassium channel protei...   224   1e-58
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   224   2e-58
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   224   2e-58
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   223   4e-58
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   222   7e-58
gi|25952087 potassium voltage-gated channel, shaker-related subf...   219   6e-57
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   218   7e-57

>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  960 bits (2482), Expect = 0.0
 Identities = 477/477 (100%), Positives = 477/477 (100%)

Query: 1   MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCD 60
           MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCD
Sbjct: 1   MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCD 60

Query: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120
           DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS
Sbjct: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120

Query: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNP 180
           YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNP
Sbjct: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNP 180

Query: 181 GYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTF 240
           GYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTF
Sbjct: 181 GYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTF 240

Query: 241 ELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLM 300
           ELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLM
Sbjct: 241 ELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLM 300

Query: 301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT 360
           RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT
Sbjct: 301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT 360

Query: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420
           IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ
Sbjct: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420

Query: 421 KQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSLR 477
           KQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSLR
Sbjct: 421 KQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSLR 477


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  513 bits (1320), Expect = e-145
 Identities = 252/445 (56%), Positives = 325/445 (73%), Gaps = 4/445 (0%)

Query: 19  IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
           + +NVGGFK+ +   TLLRFP TRLG+LL CHS EAILELCDDY    +E+YFDRNP LF
Sbjct: 17  VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLF 76

Query: 79  PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQ 138
            YVL+FY+TGKLHVM ELCVFSF QEIEYWGINE FIDSCCS  Y  RK E  ++ WD++
Sbjct: 77  RYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQK 136

Query: 139 SDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVM 198
           S   ST SSF+E   F  +  KFD    G  R+++W+ ++NP Y + +++ +I S+ VV+
Sbjct: 137 SHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVL 196

Query: 199 GSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKN 258
            SI+ MC++S+ +FQ  D +    +DP  E VE   IAWFT EL  R A AP   KF+KN
Sbjct: 197 ASIVAMCVHSMSEFQNEDGE---VDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKN 253

Query: 259 ALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318
            LN+ID +SI+PFY TL V+   E +  + N+G+V Q+LRLMRIFRILKLARHS GLRSL
Sbjct: 254 PLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSL 313

Query: 319 GATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEEN-EGLATIPACWWWATVSMTTVGY 377
           GATL++SY EVGLLLL+LSVGISIFSV+ Y++EK+++   L +IP CWWWAT+SMTTVGY
Sbjct: 314 GATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGY 373

Query: 378 GDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMK 437
           GD  P T AGKL AS CI+ GILVV LPIT+IFNKFS +Y++QK ++    S D  +   
Sbjct: 374 GDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCH 433

Query: 438 EVPSVNLRDYYAHKVKSLMASLTNM 462
           E+P  N+RD YA ++ + + SL+++
Sbjct: 434 ELPYFNIRDIYAQRMHTFITSLSSV 458


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  467 bits (1202), Expect = e-132
 Identities = 241/472 (51%), Positives = 315/472 (66%), Gaps = 19/472 (4%)

Query: 16  DGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNP 75
           D  +R+NVGG +R+L +  L RFP TRLGRL    S E    LCDDYD+  REFYFDR+P
Sbjct: 49  DEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHP 108

Query: 76  ELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKW 135
             F  +LHFY TG LHV+ ELCVF+F QE +YWG+ E  + +CC   Y  R++  +   W
Sbjct: 109 GFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLT-QPHAW 167

Query: 136 DEQSDQESTTSSF-DEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSI 194
           DE SD  S+     DEI     + +++     G  RR+LWL ++NPGYS+ S++FS +SI
Sbjct: 168 DEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSI 227

Query: 195 LVVMGSIITMCLNSLPDFQIPD------------SQGNPGEDPRFEIVEHFGIAWFTFEL 242
            VV+ SI  MC++SLP++Q  +            S     +DP    +E+F IAWF+FE+
Sbjct: 228 SVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEV 287

Query: 243 VARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV--ESTPTLANLGRVAQVLRLM 300
            +R  +AP    FF + LNLID++S++PFY+TL+  + +  +      +LG+V QV RLM
Sbjct: 288 SSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLM 347

Query: 301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT 360
           RIFR+LKLARHSTGLRSLGATLK+SY+EVG+LLLYL+VG+S+FS VAYT EKEE+ G  T
Sbjct: 348 RIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNT 407

Query: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420
           IPACWWW TVSMTTVGYGDVVP T AGKL AS CIL GILVV LPIT+IFNKFSHFYRRQ
Sbjct: 408 IPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQ 467

Query: 421 KQLESAMRSC---DFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSE 469
           K LE+A+R+    +F D +  +  V+       +  S      ++   +PSE
Sbjct: 468 KALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSE 519


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  379 bits (973), Expect = e-105
 Identities = 194/472 (41%), Positives = 300/472 (63%), Gaps = 16/472 (3%)

Query: 8   DVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQR 67
           D+  +      ++INVGG    +   TL R P TRLG+L  C++ E++LE+CDDY+  + 
Sbjct: 26  DIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNEN 85

Query: 68  EFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRK 127
           E++FDR+P  F  +L+FY TGKLH+M E+C  SF QE++YWGI+E +++SCC   YH +K
Sbjct: 86  EYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 145

Query: 128 VEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSR 187
                E+ +E+  +E+ T    E         +FD     + R++LW  L+ P  SV ++
Sbjct: 146 -----EQMNEELRREAETMRERE-------GEEFDNTCCPDKRKKLWDLLEKPNSSVAAK 193

Query: 188 VFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFA 247
           + +I+SIL ++ S I + LN+LP+ Q  D  G   ++ +   VE   IAWFT E + RF 
Sbjct: 194 ILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFL 253

Query: 248 VAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILK 307
            +P+  KFFK  LN+IDL++I+P+Y+T+ +    +S     N+ RV Q+ R+MRI RILK
Sbjct: 254 SSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILK 313

Query: 308 LARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEEN-EGLATIPACWW 366
           LARHSTGL+SLG TL+ SY E+GLL+L+L++GI IFS + +  EK+E+     +IPA +W
Sbjct: 314 LARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFW 373

Query: 367 WATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESA 426
           WAT++MTTVGYGD+ P T  GK+    C +AG+LV+ LPI +I N FS FY+ QK+ E A
Sbjct: 374 WATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKA 433

Query: 427 MRSCDFGDGMK---EVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDS 475
           ++  +  +  K    + S+NL+D +A  ++ +  ++     S+ ++ S +D+
Sbjct: 434 IKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDN 485


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  375 bits (964), Expect = e-104
 Identities = 188/441 (42%), Positives = 285/441 (64%), Gaps = 16/441 (3%)

Query: 19  IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
           +R+NVGG    +   TL R P TRLG+L  C++ +++LE+CDDY     E++FDR+P  F
Sbjct: 33  VRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAF 92

Query: 79  PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQ 138
             +L+FY TG+LH+M E+C  SFSQE++YWGI+E +++SCC   YH +K     E+ +E+
Sbjct: 93  TSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKK-----EQMNEE 147

Query: 139 SDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVM 198
             +E+ T    E         +FD       R++LW  L+ P  SV +++ +I+SI+ ++
Sbjct: 148 LKREAETLRERE-------GEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIV 200

Query: 199 GSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKN 258
            S I + LN+LP+ Q  D  G   ++P+   VE   IAWFT E + RF  +P   KFFK 
Sbjct: 201 LSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKG 260

Query: 259 ALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318
            LN IDL++I+P+Y+T+ +    +S     N+ RV Q+ R+MRI RILKLARHSTGL+SL
Sbjct: 261 PLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSL 320

Query: 319 GATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENE-GLATIPACWWWATVSMTTVGY 377
           G TL+ SY E+GLL+L+L++GI IFS + +  EK+E++    +IPA +WWAT++MTTVGY
Sbjct: 321 GFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGY 380

Query: 378 GDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMK 437
           GD+ P T  GK+    C +AG+LV+ LPI +I N FS FY+ QK+ E A++  +  +  K
Sbjct: 381 GDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAK 440

Query: 438 ---EVPSVNLRDYYAHKVKSL 455
               + S+N++D +A  ++ +
Sbjct: 441 RNGSIVSMNMKDAFARSIEMM 461


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  346 bits (888), Expect = 2e-95
 Identities = 202/462 (43%), Positives = 270/462 (58%), Gaps = 50/462 (10%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSR----------EAILELCDDYDDVQREFY 70
           +NVGG +  L    L  FP TRLG+L +  +            + LELCDD + V  E++
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 71  FDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEP 130
           FDR+ + F YVLH+Y TG+LHVM +LC  SF QEI+YWGI+E  IDSCC   Y  RK   
Sbjct: 103 FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRK--E 160

Query: 131 EQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFS 190
             E  D + D E   S        +     F   P    R++LW  L+ PG S  +R+F 
Sbjct: 161 LSETLDFKKDTEDQESQ-------HESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFG 213

Query: 191 ILSILVVMGSIITMCLNSLP----DFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARF 246
           ++SI+ V+ SII M L S      D Q+             EI+E+  I+WFT E V RF
Sbjct: 214 VISIIFVVVSIINMALMSAELSWLDLQL------------LEILEYVCISWFTGEFVLRF 261

Query: 247 AVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLV--VESTPTLANLGRVAQVLRLMRIFR 304
               D  +F +   N+IDL++I+PFYITL+V  +   ++T  L N+GR+ QVLRL+R  R
Sbjct: 262 LCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALR 321

Query: 305 ILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE-ENEGLATIPA 363
           +LKL RHSTGLRSLG T+   Y+EVGLLLL+LSVGISIFS V Y  E+   +    ++P 
Sbjct: 322 MLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPC 381

Query: 364 CWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQL 423
            WWWAT SMTTVGYGD+ P TT GK+ A  CIL+GILV+ LPI +I ++FS  Y   K  
Sbjct: 382 AWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLK 441

Query: 424 ESAMRSCDFGDGMKEVP---------SVNLRDYYAHKVKSLM 456
           E+A+R     + +K++          SVNLRD YA  +  ++
Sbjct: 442 EAAVRQ---REALKKLTKNIATDSYISVNLRDVYARSIMEML 480


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  307 bits (786), Expect = 2e-83
 Identities = 166/425 (39%), Positives = 257/425 (60%), Gaps = 22/425 (5%)

Query: 10  SEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSR--EAILELCDDYDDVQR 67
           S A  +D EI +NVGG ++ L    L ++PETRL  L+ C +   + I  LCDDYD  +R
Sbjct: 16  SSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKR 75

Query: 68  EFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRK 127
           EFYFDR+P+ F  V+  Y+ G++H+   +C   F  E+++W ++  F+D CC      ++
Sbjct: 76  EFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKR 135

Query: 128 VEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQ---LWLALDNPGYSV 184
            E E+     Q          D++     DA++      G +RR    +W  L+ P  S 
Sbjct: 136 EELEEIARRVQL-------ILDDLGV---DAAE------GRWRRCQKCVWKFLEKPESSC 179

Query: 185 LSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVA 244
            +RV ++LS L+++ S + MC+ ++P+ Q+ D++GN  E P  E VE   I WFT E + 
Sbjct: 180 PARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLL 239

Query: 245 RFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFR 304
           R   +P+ L F  + +N++D+++I+PFY++L +  +      L N+ +  Q LR+MRI R
Sbjct: 240 RLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIAR 299

Query: 305 ILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGL-ATIPA 363
           I KLARHS+GL++L   LK S+KE+GLLL+YL+VGI +FS + YT+E+   E L  +IP 
Sbjct: 300 IFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQ 359

Query: 364 CWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQL 423
            +WWA ++MTTVGYGD+ P TT GKL A+   L G++ + LPI  I N F  +Y +Q+ L
Sbjct: 360 SFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVL 419

Query: 424 ESAMR 428
           E+A +
Sbjct: 420 ETAAK 424


>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
           [Homo sapiens]
          Length = 519

 Score =  290 bits (743), Expect = 2e-78
 Identities = 167/430 (38%), Positives = 257/430 (59%), Gaps = 32/430 (7%)

Query: 18  EIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPEL 77
           EI INVGG +  L   TL RFP +RL +L LC S E I++LCDDYD+  +EF+FDR+P  
Sbjct: 60  EILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSA 119

Query: 78  FPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDE 137
           F  ++ F   GKL ++ E+C  SF +E+ YWGI E  ++ CC      RK+  + E+ +E
Sbjct: 120 FGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCL-----RKLLRKLEELEE 174

Query: 138 QSD--QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSIL 195
            +   +E       E     + +S++     G    +L   ++NP   +  +VF+ LSIL
Sbjct: 175 LAKLHREDVLRQQRETRRPASHSSRW-----GLCMNRLREMVENPQSGLPGKVFACLSIL 229

Query: 196 VVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFE-IVEHFGIAWFTFELVARFAVAPDFLK 254
            V  + +++C++++PD +  + QG       +  IVE   +AWF+ E   RF  A D  +
Sbjct: 230 FVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQ 289

Query: 255 FFKNALNLIDLMSIVPFYITLVVNLVVESTPT----------LANLGRVAQVLRLMRIFR 304
           FF+  LN+ID+++I P+Y++L V+   E  P           L  +G V +VLR +RI  
Sbjct: 290 FFQGPLNIIDILAISPYYVSLAVS---EEPPEDGERPSGSSYLEKVGLVLRVLRALRILY 346

Query: 305 ILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGL--ATIP 362
           +++LARHS GL++LG T++   +E GLLLL+L+V I++FS + Y  EKE    L   +IP
Sbjct: 347 VMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIP 406

Query: 363 ACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY----R 418
           A +WWA +SMTTVGYGD+VP +  G++ A + IL+GIL++  P T IF+ FSH Y    +
Sbjct: 407 ASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKK 466

Query: 419 RQKQLESAMR 428
            Q+QL++ +R
Sbjct: 467 EQEQLQARLR 476


>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
          Length = 545

 Score =  290 bits (741), Expect = 3e-78
 Identities = 158/417 (37%), Positives = 243/417 (58%), Gaps = 19/417 (4%)

Query: 19  IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
           + +NVGG   +L    L  FP+TRLGRL    SR   L LCDDY++   E++FDR+P +F
Sbjct: 99  LNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVF 158

Query: 79  PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVE-PEQEKWDE 137
             V +FY +G L V+  LC   F +E+ YWG+   +   CC   +  R+ E  E+ K   
Sbjct: 159 QLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQH 218

Query: 138 QSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVV 197
           +   ++     +E+          D +  G  RR+LW  ++ P  SV ++   + S   V
Sbjct: 219 ELRAQAQVEEAEELFR--------DMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFV 270

Query: 198 MGSIITMCLNSLPDFQIPDSQGNPGED--PRFEIVEHFGIAWFTFELVARFAVAPDFLKF 255
           + S++ + LN++ + Q    QG  G D  P  E VE   + +FT E + R A  PD  +F
Sbjct: 271 LVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRF 330

Query: 256 FKNALNLIDLMSIVPFYITLVVNLVV-------ESTPTLANLGRVAQVLRLMRIFRILKL 308
            ++ALNL+DL++I+P Y+ L++           ++  ++  +G+V +V+RLMRIFRILKL
Sbjct: 331 ARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKL 390

Query: 309 ARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE-ENEGLATIPACWWW 367
           ARHSTGLR+ G TL+  Y++VG LLL++++GI  FS   Y++E +  +    TIP  WWW
Sbjct: 391 ARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWW 450

Query: 368 ATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLE 424
           A VS++TVGYGD+ P T  G+  A  CI  GI++  +PI++++NKFS +Y + K  E
Sbjct: 451 AAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYE 507


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  282 bits (721), Expect = 5e-76
 Identities = 164/419 (39%), Positives = 244/419 (58%), Gaps = 26/419 (6%)

Query: 19  IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
           I INVGG K  L   TL  FP TRLG+L  C + + IL +CDDYD    EF+FDRNP  F
Sbjct: 65  IIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAF 124

Query: 79  PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEP-----EQE 133
             +L F   GKL ++ E+C  SF +E+ YWGI E  +D CC   Y  +K+E      E+E
Sbjct: 125 GTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYL-QKIEEFAEMVERE 183

Query: 134 KWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILS 193
           + D+  D E   S            ++ +G+ LG   R+L   ++ P   +  +VF+ LS
Sbjct: 184 EEDDALDSEGRDS---------EGPAEGEGR-LGRCMRRLRDMVERPHSGLPGKVFACLS 233

Query: 194 ILVVMGSIITMCLNSLPDFQIPDSQGNPGE-DPRFEIVEHFGIAWFTFELVARFAVAPDF 252
           +L V  + + + +++LP  +  + QG+  +      IVE   + WF+ E + R   AP  
Sbjct: 234 VLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSK 293

Query: 253 LKFFKNALNLIDLMSIVPFYITLVVNLVV-------ESTPTLANLGRVAQVLRLMRIFRI 305
             F ++ L LIDL++I+P+YITL+V+               L  +G V +VLR +RI  +
Sbjct: 294 FAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYV 353

Query: 306 LKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE--ENEGLATIPA 363
           ++LARHS GL++LG T +   +E GLLLL+L V I++F+ + Y IE E  ++    +IPA
Sbjct: 354 MRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPA 413

Query: 364 CWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQ 422
           C+WWA ++MTTVGYGD+VP +T G++ A + IL+GIL++  P+T IF+ FS  Y   KQ
Sbjct: 414 CYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQ 472


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  260 bits (664), Expect = 2e-69
 Identities = 143/412 (34%), Positives = 229/412 (55%), Gaps = 26/412 (6%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           +NVGG +  L    L  FP  R+ RL  C S   +LE+CDDYD  + E++FDR+ E F +
Sbjct: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72

Query: 81  VLHFYHT-GKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L +    GKL     +C  SF  E+ YWG+    ++ CC            Q + D++ 
Sbjct: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC------------QRRLDDRM 120

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWL-----ALDNPGYSVLSRVFSILSI 194
               T  S DE      D ++  G      RR  WL       + P  S+ +++ + +S+
Sbjct: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRR--WLERMRRTFEEPTSSLAAQILASVSV 178

Query: 195 LVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLK 254
           + V+ S++ +C ++LPD++   +  N   D R  I+E   I WFT E + RF V+ +  +
Sbjct: 179 VFVIVSMVVLCASTLPDWRNAAAD-NRSLDDRSRIIEAICIGWFTAECIVRFIVSKNKCE 237

Query: 255 FFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTG 314
           F K  LN+IDL++I P+YI++++ +       L   G   +VLR+MRIF ++KLARH  G
Sbjct: 238 FVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIG 297

Query: 315 LRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIE-----KEENEGLATIPACWWWAT 369
           L++LG TLK  Y+E+ +LL+++ V ++IFS ++  +E     +  N+   +IPA  WW  
Sbjct: 298 LQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVI 357

Query: 370 VSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQK 421
           +SMTTVGYGD+ P T  G++    C+++GI+++ LPIT I++ F   Y   K
Sbjct: 358 ISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 409


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  255 bits (652), Expect = 5e-68
 Identities = 143/423 (33%), Positives = 230/423 (54%), Gaps = 37/423 (8%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           +NVGG +  L    L  FP  R+ RL  C S   +LE+CDDYD  + E++FDR+ E F +
Sbjct: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72

Query: 81  VLHFYHT-GKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L +    GKL     +C  SF  E+ YWG+    ++ CC            Q + D++ 
Sbjct: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC------------QRRLDDRM 120

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWL-----ALDNPGYSVLSRVFSILSI 194
               T  S DE      D ++  G      RR  WL       + P  S+ +++ + +S+
Sbjct: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRR--WLERMRRTFEEPTSSLAAQILASVSV 178

Query: 195 LVVMGSIITMCLNSLPDFQIPDSQGN-----------PGEDPRFEIVEHFGIAWFTFELV 243
           + V+ S++ +C ++LPD++   +              PG +P   I+E   I WFT E +
Sbjct: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPS-GIIEAICIGWFTAECI 237

Query: 244 ARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIF 303
            RF V+ +  +F K  LN+IDL++I P+YI++++ +       L   G   +VLR+MRIF
Sbjct: 238 VRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIF 297

Query: 304 RILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIE-----KEENEGL 358
            ++KLARH  GL++LG TLK  Y+E+ +LL+++ V ++IFS ++  +E     +  N+  
Sbjct: 298 WVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDF 357

Query: 359 ATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYR 418
            +IPA  WW  +SMTTVGYGD+ P T  G++    C+++GI+++ LPIT I++ F   Y 
Sbjct: 358 TSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417

Query: 419 RQK 421
             K
Sbjct: 418 ELK 420


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  254 bits (649), Expect = 1e-67
 Identities = 143/419 (34%), Positives = 232/419 (55%), Gaps = 25/419 (5%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           INVGG + RL    L R P  RL RL  C   + +L +CDDYD  + EF+FDR+P  F  
Sbjct: 21  INVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFFFDRSPCAFRA 80

Query: 81  VLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKW--DEQ 138
           ++     GKL ++   C  +F  E+ YWGI+E  ++ CC      R+ E  + +    E+
Sbjct: 81  IVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPTER 140

Query: 139 SDQESTTSSFDEILAFYNDASKFDGQPLGNF---RRQLWLALDNPGYSVLSRVFSILSIL 195
             Q S   +                 P G     RR+L   +DNP   +  ++F+ +S+ 
Sbjct: 141 GAQGSPARALG---------------PRGRLQRGRRRLRDVVDNPHSGLAGKLFACVSVS 185

Query: 196 VVMGSIITMCLNSLPDFQIPDSQGNPGEDPR-FEIVEHFGIAWFTFELVARFAVAPDFLK 254
            V  + + +CL+++PD +  + +G      R   ++E   +AWF+FE + R   A     
Sbjct: 186 FVAVTAVGLCLSTMPDIRAEEERGECSPKCRSLFVLETVCVAWFSFEFLLRSLQAESKCA 245

Query: 255 FFKNALNLIDLMSIVPFYITLVVNLVV--ESTPTLANLGRVAQVLRLMRIFRILKLARHS 312
           F +  LN+ID+++++PFY++L++ L      T  L   G V ++LR +R+  +++LARHS
Sbjct: 246 FLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRALRVLYVMRLARHS 305

Query: 313 TGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE--ENEGLATIPACWWWATV 370
            GLRSLG T++   +E GLLLL+L V +++F+ + +  E+E       +++PA +WWA +
Sbjct: 306 LGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVI 365

Query: 371 SMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRS 429
           SMTTVGYGD+VP +  G++ A + IL+GIL++  P+T IF+ FS  Y   K+ +    S
Sbjct: 366 SMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAAS 424


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  247 bits (631), Expect = 1e-65
 Identities = 147/432 (34%), Positives = 232/432 (53%), Gaps = 62/432 (14%)

Query: 13  NVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFD 72
           N  +  + IN+ G +   +  TL +FPET LG       RE  ++    +D ++ E++FD
Sbjct: 82  NEGNQRVIINIAGLRFETQLRTLSQFPETLLG------DREKRMQF---FDSMRNEYFFD 132

Query: 73  RNPELFPYVLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPE 131
           RN   F  +L++Y +G K+   A + +  F+ EI ++ +                     
Sbjct: 133 RNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGS------------------- 173

Query: 132 QEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSI 191
            E  D+  + E      + +L            P  +  RQ WL  + P  S  +R  ++
Sbjct: 174 -EAMDQFREDEGFIKDPETLL------------PTNDIHRQFWLLFEYPESSSAARAVAV 220

Query: 192 LSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPR----------------FEIVEHFGI 235
           +S+LVV+ SI   CL +LP+F+  D +     DP                 F +VE   I
Sbjct: 221 VSVLVVVISITIFCLETLPEFR-EDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCI 279

Query: 236 AWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVA- 294
            WFTFELV RF V P    FF+N +N+ID++SI+P++ TL+  LV E+ P+      +A 
Sbjct: 280 VWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAI 339

Query: 295 -QVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE 353
            +++RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E +
Sbjct: 340 LRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVD 399

Query: 354 ENEG-LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNK 412
           E E   ++IP  +WWA V+MTTVGYGD+ P T  GK+  + C +AG+L + LP+ +I + 
Sbjct: 400 EPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSN 459

Query: 413 FSHFYRRQKQLE 424
           F++FY R+ + E
Sbjct: 460 FNYFYHRETENE 471


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  239 bits (609), Expect = 5e-63
 Identities = 151/439 (34%), Positives = 228/439 (51%), Gaps = 78/439 (17%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           +NV G +   R+ TL RFP+T LG      +R         YDD +RE++FDR+   F  
Sbjct: 17  LNVAGLRFETRARTLGRFPDTLLGD----PARRGRF-----YDDARREYFFDRHRPSFDA 67

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           VL++Y +G +L   A + +  F +E+ ++G+    +         G  V PE+       
Sbjct: 68  VLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARL--REDEGCPVPPERPL----- 120

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
                                    P   F RQLWL  + P  S  +RV +++S+LV++ 
Sbjct: 121 -------------------------PRRAFARQLWLLFEFPESSQAARVLAVVSVLVILV 155

Query: 200 SIITMCLNSLPDFQ--------------------IPDSQGNPGEDPR------FEIVEHF 233
           SI+  CL +LPDF+                    +  S   PG  PR      F +VE  
Sbjct: 156 SIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETL 215

Query: 234 GIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNL-----VVESTPTLA 288
            I WF+FEL+ R  V P    FFKN +NLID ++I+P+++ L   L     V +   +LA
Sbjct: 216 CICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLA 275

Query: 289 NLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAY 348
               + +V+RL+R+FRI KL+RHS GL+ LG TL+ S +E+GLL+ +L +G+ +FS   Y
Sbjct: 276 ----ILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVY 331

Query: 349 TIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPIT 407
             E +  +    +IP  +WWA V+MTTVGYGD+ P T  GK+  S C +AG+L + LP+ 
Sbjct: 332 FAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVP 391

Query: 408 LIFNKFSHFYRRQKQLESA 426
           +I + FS+FY R+ + E A
Sbjct: 392 VIVSNFSYFYHRETEGEEA 410


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  233 bits (594), Expect = 3e-61
 Identities = 145/432 (33%), Positives = 228/432 (52%), Gaps = 72/432 (16%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           IN+ G +   +  TL +FPET LG            +    +D ++ E++FDRN   F  
Sbjct: 37  INISGLRFETQLKTLAQFPETLLGDPK---------KRMRYFDPLRNEYFFDRNRPSFDA 87

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L++Y +G +L     + +  FS+EI ++ + E              ++  E E + ++ 
Sbjct: 88  ILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE-----------EAMEMFREDEGYIKEE 136

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
           ++                       P   F+RQ+WL  + P  S  +R+ +I+S++V++ 
Sbjct: 137 ERPL---------------------PENEFQRQVWLLFEYPESSGPARIIAIVSVMVILI 175

Query: 200 SIITMCLNSLPDFQ--------------------IPDSQGNPGEDPRFEIVEHFGIAWFT 239
           SI++ CL +LP F+                    I   Q     DP F IVE   I WF+
Sbjct: 176 SIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFF-IVETLCIIWFS 234

Query: 240 FELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVA----- 294
           FE + RF   P    FF N +N+ID+++I+P++ITL   L  +  P  A  G+ A     
Sbjct: 235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEK--PEDAQQGQQAMSLAI 292

Query: 295 -QVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE 353
            +V+RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E +
Sbjct: 293 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 352

Query: 354 ENEG-LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNK 412
           E E    +IP  +WWA VSMTTVGYGD+VP T  GK+  S C +AG+L + LP+ +I + 
Sbjct: 353 ERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSN 412

Query: 413 FSHFYRRQKQLE 424
           F++FY R+ + E
Sbjct: 413 FNYFYHRETEGE 424


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  233 bits (593), Expect = 4e-61
 Identities = 155/478 (32%), Positives = 241/478 (50%), Gaps = 89/478 (18%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           IN+ G +   +  TL +FP T LG            +    +D ++ E++FDRN   F  
Sbjct: 41  INISGLRFETQLKTLAQFPNTLLGNPK---------KRMRYFDPLRNEYFFDRNRPSFDA 91

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L++Y +G +L     + +  FS+EI+++ + E                           
Sbjct: 92  ILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGE--------------------------- 124

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
                   F E   F  +  +    P   ++RQ+WL  + P  S  +RV +I+S++V++ 
Sbjct: 125 ---EAMEKFREDEGFIKEEER--PLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILI 179

Query: 200 SIITMCLNSLPDFQIPDS---------------QGNPGEDPRFEIVEHFGIAWFTFELVA 244
           SI+  CL +LP+ +                     N   DP F IVE   I WF+FELV 
Sbjct: 180 SIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFF-IVETLCIIWFSFELVV 238

Query: 245 RFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV-------ESTPTLANLGRVAQVL 297
           RF   P    FFKN +N ID+++I+P++ITL   +         E   +LA    + +V+
Sbjct: 239 RFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA----ILRVI 294

Query: 298 RLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG 357
           RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E EE E 
Sbjct: 295 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354

Query: 358 -LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHF 416
             ++IP  +WWA VSMTTVGYGD+ P T  GK+  S C +AG+L + LP+ +I + F++F
Sbjct: 355 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 414

Query: 417 YRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLND 474
           Y R+ + E   +       +  V S NL            AS +++SR S S +S ++
Sbjct: 415 YHRETEGEEQAQ-------LLHVSSPNL------------ASDSDLSRRSSSTMSKSE 453


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  229 bits (585), Expect = 3e-60
 Identities = 137/389 (35%), Positives = 205/389 (52%), Gaps = 34/389 (8%)

Query: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120
           D+    REF+FDR+P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  ++ CC 
Sbjct: 94  DHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCW 153

Query: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAF----YNDASKFDGQ--PLGNFRR--- 171
            +Y   +   E     E  D        DE LA       DA+   G     G +RR   
Sbjct: 154 MTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQP 213

Query: 172 QLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNP---------- 221
           ++W   ++P  S  +R  +  S+  ++ SI T CL +   F I  ++  P          
Sbjct: 214 RMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQ 273

Query: 222 ---GEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278
                DP    VE   + WFTFE + R   +P+ L+F KN LN+ID ++I+PFY  L V 
Sbjct: 274 YEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY--LEVG 331

Query: 279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSV 338
           L   S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391

Query: 339 GISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGK 388
           G+ IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G 
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451

Query: 389 LTASACILAGILVVVLPITLIFNKFSHFY 417
           L  + C LAG+L + +P+ +I N F  +Y
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  229 bits (585), Expect = 3e-60
 Identities = 137/389 (35%), Positives = 205/389 (52%), Gaps = 34/389 (8%)

Query: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120
           D+    REF+FDR+P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  ++ CC 
Sbjct: 94  DHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCW 153

Query: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAF----YNDASKFDGQ--PLGNFRR--- 171
            +Y   +   E     E  D        DE LA       DA+   G     G +RR   
Sbjct: 154 MTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQP 213

Query: 172 QLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNP---------- 221
           ++W   ++P  S  +R  +  S+  ++ SI T CL +   F I  ++  P          
Sbjct: 214 RMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQ 273

Query: 222 ---GEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278
                DP    VE   + WFTFE + R   +P+ L+F KN LN+ID ++I+PFY  L V 
Sbjct: 274 YEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY--LEVG 331

Query: 279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSV 338
           L   S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391

Query: 339 GISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGK 388
           G+ IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G 
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451

Query: 389 LTASACILAGILVVVLPITLIFNKFSHFY 417
           L  + C LAG+L + +P+ +I N F  +Y
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  229 bits (585), Expect = 3e-60
 Identities = 137/389 (35%), Positives = 205/389 (52%), Gaps = 34/389 (8%)

Query: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120
           D+    REF+FDR+P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  ++ CC 
Sbjct: 94  DHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCW 153

Query: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAF----YNDASKFDGQ--PLGNFRR--- 171
            +Y   +   E     E  D        DE LA       DA+   G     G +RR   
Sbjct: 154 MTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQP 213

Query: 172 QLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNP---------- 221
           ++W   ++P  S  +R  +  S+  ++ SI T CL +   F I  ++  P          
Sbjct: 214 RMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQ 273

Query: 222 ---GEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278
                DP    VE   + WFTFE + R   +P+ L+F KN LN+ID ++I+PFY  L V 
Sbjct: 274 YEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY--LEVG 331

Query: 279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSV 338
           L   S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391

Query: 339 GISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGK 388
           G+ IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G 
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451

Query: 389 LTASACILAGILVVVLPITLIFNKFSHFY 417
           L  + C LAG+L + +P+ +I N F  +Y
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  227 bits (578), Expect = 2e-59
 Identities = 139/428 (32%), Positives = 222/428 (51%), Gaps = 65/428 (15%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           IN+ G +   +  TL +FPET LG                 +D ++ E++FDRN   F  
Sbjct: 108 INISGLRFETQLKTLCQFPETLLGDPK---------RRMRYFDPLRNEYFFDRNRPSFDA 158

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L++Y +G ++     + +  FS+EI ++ + E                           
Sbjct: 159 ILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGE--------------------------- 191

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
                   F E   F  +  +    P  +F+RQ+WL  + P  S  +R  +I+S+LV++ 
Sbjct: 192 ---EAMEKFREDEGFLREEER--PLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILI 246

Query: 200 SIITMCLNSLPDFQIP------------DSQGNPGEDPR---------FEIVEHFGIAWF 238
           SI+  CL +LP+F+              ++ GN     R         F +VE   I WF
Sbjct: 247 SIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWF 306

Query: 239 TFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV-ESTPTLANLGRVAQVL 297
           +FEL+ RF   P    F +N +NLID+++I+P++ITL   L   +     A    + +V+
Sbjct: 307 SFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVI 366

Query: 298 RLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEE-NE 356
           RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E ++   
Sbjct: 367 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTS 426

Query: 357 GLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHF 416
           G ++IP  +WWA V+MTTVGYGD+ P T  GK+  S C +AG+L + LP+ +I + F++F
Sbjct: 427 GFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 486

Query: 417 YRRQKQLE 424
           Y R+ + E
Sbjct: 487 YHRETEGE 494


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  225 bits (573), Expect = 8e-59
 Identities = 149/468 (31%), Positives = 224/468 (47%), Gaps = 72/468 (15%)

Query: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
           + G+I INVGG +      TL   P TRL  L      EA      DYD    EF+FDR+
Sbjct: 86  DSGKIVINVGGVRHETYRSTLRTLPGTRLAGLT---EPEAAARF--DYDPGADEFFFDRH 140

Query: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134
           P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  +++CC  +Y   +   E   
Sbjct: 141 PGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALD 200

Query: 135 WDEQSDQESTTSSFDEILAF--------------------------YNDASKFDGQPLGN 168
             E  D     ++ +   A                           + DA    G P G 
Sbjct: 201 SFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGG 260

Query: 169 -----------FRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDF----- 212
                      ++ ++W   ++P  S  +R  +  S+  ++ SI T CL +   F     
Sbjct: 261 AGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISN 320

Query: 213 ----QIPDSQGNPGE---------DPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNA 259
               Q     G P E         +P    VE   + WFTFE + R    PD ++F K++
Sbjct: 321 KTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSS 380

Query: 260 LNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLG 319
           LN+ID ++I+PFY  L V L   S+    ++    +V+R +RI RI KL RH  GLR LG
Sbjct: 381 LNIIDCVAILPFY--LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG 438

Query: 320 ATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEK----------EENEGLATIPACWWWAT 369
            TL+ S  E  LL+++L++G+ IF+ + Y  E+            +     IP  +WWA 
Sbjct: 439 HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAV 498

Query: 370 VSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY 417
           V+MTT+GYGD+ P T +G L  + C LAG+L + +P+ +I N F  +Y
Sbjct: 499 VTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  224 bits (571), Expect = 1e-58
 Identities = 144/446 (32%), Positives = 224/446 (50%), Gaps = 51/446 (11%)

Query: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
           E   I INVGG + +    TL   P TRL  L    +         DYD    EF+FDR+
Sbjct: 6   ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRH 60

Query: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQ-- 132
           P +F ++L++Y TGKLH  A++C   + +E+ +WGI+E  ++ CC  +Y   +   E   
Sbjct: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120

Query: 133 -------EKWDEQSDQESTTSSFD-----EILAFYNDASKFDGQPLGNFRR---QLWLAL 177
                  +   + +D +    S D     E+      +   DG+P G +RR   ++W   
Sbjct: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180

Query: 178 DNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPR----------- 226
           ++P  S  +R  +  S+  ++ SI T CL +   F  P       E+ R           
Sbjct: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFN-PIVNKTEIENVRNGTQVRYYREA 239

Query: 227 -----FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV 281
                   +E   + WFTFE + R    P+ ++F KN+LN+ID ++I+PFY  L V L  
Sbjct: 240 ETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFY--LEVGLSG 297

Query: 282 ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGIS 341
            S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++G+ 
Sbjct: 298 LSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 357

Query: 342 IFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTA 391
           IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G L  
Sbjct: 358 IFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVG 417

Query: 392 SACILAGILVVVLPITLIFNKFSHFY 417
           + C LAG+L + +P+ +I N F  +Y
Sbjct: 418 ALCALAGVLTIAMPVPVIVNNFGMYY 443


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  224 bits (571), Expect = 1e-58
 Identities = 144/446 (32%), Positives = 224/446 (50%), Gaps = 51/446 (11%)

Query: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
           E   I INVGG + +    TL   P TRL  L    +         DYD    EF+FDR+
Sbjct: 6   ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRH 60

Query: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQ-- 132
           P +F ++L++Y TGKLH  A++C   + +E+ +WGI+E  ++ CC  +Y   +   E   
Sbjct: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120

Query: 133 -------EKWDEQSDQESTTSSFD-----EILAFYNDASKFDGQPLGNFRR---QLWLAL 177
                  +   + +D +    S D     E+      +   DG+P G +RR   ++W   
Sbjct: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180

Query: 178 DNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPR----------- 226
           ++P  S  +R  +  S+  ++ SI T CL +   F  P       E+ R           
Sbjct: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFN-PIVNKTEIENVRNGTQVRYYREA 239

Query: 227 -----FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV 281
                   +E   + WFTFE + R    P+ ++F KN+LN+ID ++I+PFY  L V L  
Sbjct: 240 ETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFY--LEVGLSG 297

Query: 282 ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGIS 341
            S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++G+ 
Sbjct: 298 LSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 357

Query: 342 IFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTA 391
           IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G L  
Sbjct: 358 IFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVG 417

Query: 392 SACILAGILVVVLPITLIFNKFSHFY 417
           + C LAG+L + +P+ +I N F  +Y
Sbjct: 418 ALCALAGVLTIAMPVPVIVNNFGMYY 443


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  224 bits (570), Expect = 2e-58
 Identities = 138/414 (33%), Positives = 221/414 (53%), Gaps = 38/414 (9%)

Query: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
           +D  I +NV G + +    TL R+P+T LG       +E        +++  +E++FDR+
Sbjct: 38  QDELIVLNVSGRRFQTWRTTLERYPDTLLGST----EKEFF------FNEDTKEYFFDRD 87

Query: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134
           PE+F  VL+FY TGKLH     C+ ++  E+ ++GI    I  CC   Y  RK E  +  
Sbjct: 88  PEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERL 147

Query: 135 WDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSI 194
            D+   + +  S                  P  +FR+ +W A +NP  S L+ VF  ++ 
Sbjct: 148 MDDNDSENNQES-----------------MPSLSFRQTMWRAFENPHTSTLALVFYYVTG 190

Query: 195 LVVMGSIITMCLNSLPDFQIPDSQGNP-GE--DPRFEIVEHFGIAWFTFELVARFAVAPD 251
             +  S+IT  + ++P   +P S+  P GE     F  ++   +  FT E + R   AP 
Sbjct: 191 FFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPS 250

Query: 252 FLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARH 311
             +F ++ +++ID+++I+P+YI LV+           ++      LR+ R+FRI K +RH
Sbjct: 251 RYRFIRSVMSIIDVVAIMPYYIGLVMT-------NNEDVSGAFVTLRVFRVFRIFKFSRH 303

Query: 312 STGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT-IPACWWWATV 370
           S GLR LG TLK    E+G LL  L++ I IF+ V +  EK  +    T IPA +W+  V
Sbjct: 304 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIV 363

Query: 371 SMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLE 424
           +MTT+GYGD+VP T AGK+  S C L+G+LV+ LP+ +I + FS  Y + ++ +
Sbjct: 364 TMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 417


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  224 bits (570), Expect = 2e-58
 Identities = 138/414 (33%), Positives = 221/414 (53%), Gaps = 38/414 (9%)

Query: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
           +D  I +NV G + +    TL R+P+T LG       +E        +++  +E++FDR+
Sbjct: 38  QDELIVLNVSGRRFQTWRTTLERYPDTLLGST----EKEFF------FNEDTKEYFFDRD 87

Query: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134
           PE+F  VL+FY TGKLH     C+ ++  E+ ++GI    I  CC   Y  RK E  +  
Sbjct: 88  PEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERL 147

Query: 135 WDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSI 194
            D+   + +  S                  P  +FR+ +W A +NP  S L+ VF  ++ 
Sbjct: 148 MDDNDSENNQES-----------------MPSLSFRQTMWRAFENPHTSTLALVFYYVTG 190

Query: 195 LVVMGSIITMCLNSLPDFQIPDSQGNP-GE--DPRFEIVEHFGIAWFTFELVARFAVAPD 251
             +  S+IT  + ++P   +P S+  P GE     F  ++   +  FT E + R   AP 
Sbjct: 191 FFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPS 250

Query: 252 FLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARH 311
             +F ++ +++ID+++I+P+YI LV+           ++      LR+ R+FRI K +RH
Sbjct: 251 RYRFIRSVMSIIDVVAIMPYYIGLVMT-------NNEDVSGAFVTLRVFRVFRIFKFSRH 303

Query: 312 STGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT-IPACWWWATV 370
           S GLR LG TLK    E+G LL  L++ I IF+ V +  EK  +    T IPA +W+  V
Sbjct: 304 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIV 363

Query: 371 SMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLE 424
           +MTT+GYGD+VP T AGK+  S C L+G+LV+ LP+ +I + FS  Y + ++ +
Sbjct: 364 TMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 417


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  223 bits (567), Expect = 4e-58
 Identities = 153/500 (30%), Positives = 237/500 (47%), Gaps = 116/500 (23%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           IN+ G +   +  TL  FP+T LG       R         +D ++ E++FDRN   F  
Sbjct: 45  INISGLRFETQLRTLSLFPDTLLGD----PGRRVRF-----FDPLRNEYFFDRNRPSFDA 95

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L++Y +G +L     + +  F +EI ++ + +                    E      
Sbjct: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGD--------------------EALAAFR 135

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
           + E       E      D      QP   F+RQ+WL  + P  S  +R  +I+S+LV++ 
Sbjct: 136 EDEGCLPEGGE------DEKPLPSQP---FQRQVWLLFEYPESSGPARGIAIVSVLVILI 186

Query: 200 SIITMCLNSLPDFQIPDSQGN--------------------------------PGE---- 223
           SI+  CL +LP F++    GN                                PGE    
Sbjct: 187 SIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTG 246

Query: 224 --------------DPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIV 269
                         DP F +VE   I WFTFEL+ RF+  P    FF+N +N+IDL++I 
Sbjct: 247 GSSSLSTLGGSFFTDPFF-LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIF 305

Query: 270 PFYITLVVNLVVESTPTLANLG-----------RVAQVLRLMRIFRILKLARHSTGLRSL 318
           P++ITL   LV +     A+ G            + +V+RL+R+FRI KL+RHS GL+ L
Sbjct: 306 PYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 365

Query: 319 GATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGL-ATIPACWWWATVSMTTVGY 377
           G TL+ S +E+GLL+ +L +G+ +FS   Y  E ++++ L  +IP  +WWA V+MTTVGY
Sbjct: 366 GKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGY 425

Query: 378 GDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESA----------- 426
           GD+ P T  GK+  S C +AG+L + LP+ +I + F++FY R+ + E             
Sbjct: 426 GDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQP 485

Query: 427 ---MRSCDFGDGMKEVPSVN 443
              +R+ D G G  + P  N
Sbjct: 486 APDLRATDNGLGKPDFPEAN 505


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  222 bits (565), Expect = 7e-58
 Identities = 150/488 (30%), Positives = 244/488 (50%), Gaps = 77/488 (15%)

Query: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80
           INV G +   +  TL +FPET LG        E   +    +D ++ E++FDRN   F  
Sbjct: 180 INVSGLRFETQMKTLAQFPETLLG------DPEKRTQY---FDPLRNEYFFDRNRPSFDA 230

Query: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139
           +L++Y +G +L     +    F++E++++ + E   ++   +      V  E+++     
Sbjct: 231 ILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE---EALLKFREDEGFVREEEDR----- 282

Query: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
                                    P   F++Q+WL  + P  S  +R  +I+S+LV++ 
Sbjct: 283 -----------------------ALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILI 319

Query: 200 SIITMCLNSLPDFQ------IPDSQGNPG-------------------EDPRFEIVEHFG 234
           SI+  CL +LP+F+      +  S G  G                    DP F IVE   
Sbjct: 320 SIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFF-IVETVC 378

Query: 235 IAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVES-----TPTLAN 289
           I WF+FE V R    P    FFKN +N+ID++SI+P++ITL  +L  +          A 
Sbjct: 379 IVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAM 438

Query: 290 LGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYT 349
              + +++RL+R+FRI KL+RHS GL+ LG TL+ S +E+GLL+ +L +G+ +FS   Y 
Sbjct: 439 SFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYF 498

Query: 350 IEKEE-NEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITL 408
            E +E      +IP  +WWA V+MTTVGYGD+ P T  GK+  S C +AG+L + LP+ +
Sbjct: 499 AEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPV 558

Query: 409 IFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPS 468
           I + F++FY R+ + E   +          +PS  L+ + +    S  +SL + S     
Sbjct: 559 IVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRS----STSSSLGDKSEYLEM 614

Query: 469 ELSLNDSL 476
           E  + +SL
Sbjct: 615 EEGVKESL 622


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  219 bits (557), Expect = 6e-57
 Identities = 146/459 (31%), Positives = 230/459 (50%), Gaps = 89/459 (19%)

Query: 12  ANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYF 71
           A++    + IN+ G +   +  TL +FP T LG            +    +D ++ E++F
Sbjct: 115 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPA---------KRLRYFDPLRNEYFF 165

Query: 72  DRNPELFPYVLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEP 130
           DRN   F  +L++Y +G +L     + +  F+ EI ++ +                    
Sbjct: 166 DRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLG------------------- 206

Query: 131 EQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFS 190
                DE  ++      F E   F  +  K    P   F+RQ+WL  + P  S  +R  +
Sbjct: 207 -----DEAMER------FREDEGFIKEEEK--PLPRNEFQRQVWLIFEYPESSGSARAIA 253

Query: 191 ILSILVVMGSIITMCLNSLPDFQ------------------IPDSQGN----PGEDPR-- 226
           I+S+LV++ SIIT CL +LP+F+                   P + G+    P   P   
Sbjct: 254 IVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVA 313

Query: 227 ----------FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLV 276
                     F IVE   + WFTFEL+ RF   P    F +N +N+ID+++I P++ITL 
Sbjct: 314 PLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLG 373

Query: 277 VNLVVESTPTLANLGR---------VAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYK 327
             L  E  P     G+         + +V+RL+R+FRI KL+RHS GL+ LG TL+ S +
Sbjct: 374 TELA-EQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMR 432

Query: 328 EVGLLLLYLSVGISIFSVVAYTIEKEENEG--LATIPACWWWATVSMTTVGYGDVVPGTT 385
           E+GLL+ +L +G+ +FS   Y  E + N+G   ++IP  +WWA V+MTTVGYGD+ P T 
Sbjct: 433 ELGLLIFFLFIGVILFSSAVYFAEAD-NQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITV 491

Query: 386 AGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLE 424
            GK+  S C +AG+L + LP+ +I + F++FY R+   E
Sbjct: 492 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHE 530


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  218 bits (556), Expect = 7e-57
 Identities = 140/424 (33%), Positives = 226/424 (53%), Gaps = 45/424 (10%)

Query: 11  EANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFY 70
           +A+  D  + +NV G +     +TL R+P+T LG      S +        YD    E++
Sbjct: 34  KASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGS-----SEKEFF-----YDADSGEYF 83

Query: 71  FDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVE- 129
           FDR+P++F +VL+FY TG+LH   + C+ +F +E+ ++G+    +  CC   Y  RK E 
Sbjct: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143

Query: 130 PEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPL---GNFRRQLWLALDNPGYSVLS 186
            E+   DE+++Q                    DG  L    + R++LW A +NP  S  +
Sbjct: 144 AERLAEDEEAEQAG------------------DGPALPAGSSLRQRLWRAFENPHTSTAA 185

Query: 187 RVFSILSILVVMGSIITMCLNSLP--DFQIPDSQGNP-GE--DPRFEIVEHFGIAWFTFE 241
            VF  ++   +  S+I   + ++P        S+  P GE     F  ++   +  FT E
Sbjct: 186 LVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGE 245

Query: 242 LVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMR 301
            + R   AP   +F ++ ++LID+++I+P+YI L+V       P   ++      LR+ R
Sbjct: 246 YLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLV-------PKNDDVSGAFVTLRVFR 298

Query: 302 IFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENE-GLAT 360
           +FRI K +RHS GLR LG TLK    E+G LL  L++ I IF+ V +  EK  N+    +
Sbjct: 299 VFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTS 358

Query: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420
           IPA +W+  V+MTT+GYGD+VP T AGK+  S C L+G+LV+ LP+ +I + FS  Y + 
Sbjct: 359 IPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQN 418

Query: 421 KQLE 424
           ++ +
Sbjct: 419 QRAD 422


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,956,864
Number of Sequences: 37866
Number of extensions: 717617
Number of successful extensions: 2175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 151
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 1671
Number of HSP's gapped (non-prelim): 343
length of query: 477
length of database: 18,247,518
effective HSP length: 106
effective length of query: 371
effective length of database: 14,233,722
effective search space: 5280710862
effective search space used: 5280710862
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.