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Search of human proteins with 4506467
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506467 radixin [Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506467 radixin [Homo sapiens] 1159 0.0
gi|4505257 moesin [Homo sapiens] 948 0.0
gi|161702986 ezrin [Homo sapiens] 922 0.0
gi|21614499 ezrin [Homo sapiens] 922 0.0
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 508 e-144
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 501 e-142
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 501 e-142
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 501 e-142
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 438 e-123
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 429 e-120
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 384 e-106
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 384 e-106
gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens] 166 4e-41
gi|150010540 FERM domain containing 4B [Homo sapiens] 155 1e-37
gi|116063562 FERM domain containing 4A [Homo sapiens] 150 2e-36
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 145 1e-34
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 145 1e-34
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 143 5e-34
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 142 1e-33
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 140 3e-33
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 139 7e-33
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 137 3e-32
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 137 4e-32
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 137 4e-32
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 136 5e-32
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 135 1e-31
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 135 1e-31
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 135 1e-31
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 135 1e-31
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 132 9e-31
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 1159 bits (2999), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
Query: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE
Sbjct: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
Query: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR
Sbjct: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
Query: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF
Sbjct: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK
Sbjct: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
Query: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE
Sbjct: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
Query: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP
Sbjct: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
Query: 481 PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD 540
PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD
Sbjct: 481 PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD 540
Query: 541 ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Sbjct: 541 ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 948 bits (2451), Expect = 0.0
Identities = 472/583 (80%), Positives = 523/583 (89%), Gaps = 6/583 (1%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
MPK I+VRVTTMDAELEFAIQPNTTGKQLFDQVVKT+GLREVWFFGLQY D+KG+STWLK
Sbjct: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
Query: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
LNKKVT QDV+KE+PL FKFRAKF+PEDVSEELIQ+ITQRLFFLQVKE ILND+IYCPPE
Sbjct: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
Query: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
TAVLLASYAVQ+KYGD+NKE+HK GYLA D+LLPQRVLEQHKL K+QWEERIQ WHEEHR
Sbjct: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
Query: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
GMLRED+++EYLKIAQDLEMYGVNYF IKNKKG+ELWLGVDALGLNIYE +D+LTPKIGF
Sbjct: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
EVQQMKAQAREEKHQKQ+ERA LENEKKKRE+AEKEKE+IEREKEELMERLKQIEEQT K
Sbjct: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
Query: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
AQ+ELEEQTR+ALEL+QERKRA+ EAE+L KER+ AEEAK A+ + + DQ K QEQLA E
Sbjct: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
Query: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
+AE TA+I+ LE A++KKE EA EWQ KA QEDLEKT+ ELKT MS P V
Sbjct: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMST------PHVAE 474
Query: 481 PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD 540
P ENE DE DEN AEASA+L + + RSEEER TE +KNERV+K L+AL+SELA ARD
Sbjct: 475 PAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARD 534
Query: 541 ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
E+KKT ND++HAEN++ GRDKYKTLRQIRQGNTKQRIDEFE+M
Sbjct: 535 ESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 922 bits (2382), Expect = 0.0
Identities = 447/586 (76%), Positives = 525/586 (89%), Gaps = 3/586 (0%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKT+GLREVW+FGL YVD+KG+ TWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
L+KKV+ Q+V+KENPLQFKFRAKF+PEDV+EELIQ+ITQ+LFFLQVKE IL+DEIYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
TAVLL SYAVQAK+GDYNKE+HK GYL+++RL+PQRV++QHKLT++QWE+RIQ WH EHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
GML++++M+EYLKIAQDLEMYG+NYFEIKNKKGT+LWLGVDALGLNIYE DDKLTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
EVQQMKAQAREEKHQKQLER QLE EKK+RE E+EKE++ REKEELM RL+ EE+T K
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
A++EL EQ ++AL+L++ERKRA+EEAERLE +R AA AK + +QA DQ+K+QEQLAAE
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
LAE+TAKIALLEEA+++KE+E EWQH+A AQ+DL KTKEEL VM+APPPPPPP P
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 481 PTENEHDEHDENNAEA---SAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQ 537
+ + + + AE SAELS+EG+ + R+EE+R+TE +KNERV++QL LSSEL+Q
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 538 ARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
ARDE K+T ND++H EN++ GRDKYKTLRQIRQGNTKQRIDEFEA+
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 922 bits (2382), Expect = 0.0
Identities = 447/586 (76%), Positives = 525/586 (89%), Gaps = 3/586 (0%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKT+GLREVW+FGL YVD+KG+ TWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
L+KKV+ Q+V+KENPLQFKFRAKF+PEDV+EELIQ+ITQ+LFFLQVKE IL+DEIYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
TAVLL SYAVQAK+GDYNKE+HK GYL+++RL+PQRV++QHKLT++QWE+RIQ WH EHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
GML++++M+EYLKIAQDLEMYG+NYFEIKNKKGT+LWLGVDALGLNIYE DDKLTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
EVQQMKAQAREEKHQKQLER QLE EKK+RE E+EKE++ REKEELM RL+ EE+T K
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
A++EL EQ ++AL+L++ERKRA+EEAERLE +R AA AK + +QA DQ+K+QEQLAAE
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
LAE+TAKIALLEEA+++KE+E EWQH+A AQ+DL KTKEEL VM+APPPPPPP P
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 481 PTENEHDEHDENNAEA---SAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQ 537
+ + + + AE SAELS+EG+ + R+EE+R+TE +KNERV++QL LSSEL+Q
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 538 ARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
ARDE K+T ND++H EN++ GRDKYKTLRQIRQGNTKQRIDEFEA+
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 508 bits (1308), Expect = e-144
Identities = 264/585 (45%), Positives = 384/585 (65%), Gaps = 11/585 (1%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 433
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 434 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
+ ++T D+LH EN + G K+ T++++ + K R+ FE +
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 501 bits (1290), Expect = e-142
Identities = 260/569 (45%), Positives = 376/569 (66%), Gaps = 11/569 (1%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 433
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 434 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
+ ++T D+LH EN + G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 501 bits (1290), Expect = e-142
Identities = 260/569 (45%), Positives = 376/569 (66%), Gaps = 11/569 (1%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 433
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 434 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
+ ++T D+LH EN + G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 501 bits (1290), Expect = e-142
Identities = 260/569 (45%), Positives = 376/569 (66%), Gaps = 11/569 (1%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 433
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 434 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
+ ++T D+LH EN + G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 438 bits (1126), Expect = e-123
Identities = 237/569 (41%), Positives = 349/569 (61%), Gaps = 53/569 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF
Sbjct: 19 PKTFTVRIVTMDAEMEF------------------------------------------- 35
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
N +V DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 36 NCEVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 335
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 336 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 391
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 392 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 448
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 449 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 508
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
+ ++T D+LH EN + G K+ T+++
Sbjct: 509 LKERETALDILHNENSDRGGSSKHNTIKK 537
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 429 bits (1102), Expect = e-120
Identities = 234/569 (41%), Positives = 346/569 (60%), Gaps = 52/569 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV +Q IL+++IYCPPE
Sbjct: 78 DKKVKKQ-----------------------------------------ILDEKIYCPPEA 96
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 97 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 156
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 157 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 216
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 217 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 276
Query: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 277 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 336
Query: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 337 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 392
Query: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 393 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 449
Query: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 450 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 509
Query: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
+ ++T D+LH EN + G K+ T+++
Sbjct: 510 LKERETALDILHNENSDRGGSSKHNTIKK 538
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 384 bits (985), Expect = e-106
Identities = 201/485 (41%), Positives = 312/485 (64%), Gaps = 10/485 (2%)
Query: 86 PEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPG 145
P+ + ++ + F +VK+ IL+++IYCPPE +VLLASYAVQAKYGDY+ +HK G
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
Query: 146 YLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNY 205
+LA + LLP+RV+ +++T E WEERI W+ EHRG R+++ MEYLKIAQDLEMYGVNY
Sbjct: 79 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
Query: 206 FEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAP 265
F I+NKKGTEL LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F IKP+DKK
Sbjct: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
Query: 266 DFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLEN 325
F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK +KQ+ER +L
Sbjct: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
Query: 326 EKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEE 385
EK+ RE AE+ ++ +ER ++ E E +++++ + KA ++E K ++
Sbjct: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
Query: 386 AERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEW 445
A E+E + + A A + ++ + EQ E K+A E +++ +EA +
Sbjct: 319 AAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEAEVLALKMA---EESERRAKEADQL 371
Query: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505
+ A+E + K++L + + P PP P+ P + + S + + +
Sbjct: 372 KQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDM 431
Query: 506 --MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENV-KAGRDKY 562
++ E+E+V +K++ +++QL L +E+ + + ++T D+LH EN + G K+
Sbjct: 432 KRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKH 491
Query: 563 KTLRQ 567
T+++
Sbjct: 492 NTIKK 496
Score = 29.6 bits (65), Expect = 8.0
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 384 bits (985), Expect = e-106
Identities = 201/485 (41%), Positives = 312/485 (64%), Gaps = 10/485 (2%)
Query: 86 PEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPG 145
P+ + ++ + F +VK+ IL+++IYCPPE +VLLASYAVQAKYGDY+ +HK G
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
Query: 146 YLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNY 205
+LA + LLP+RV+ +++T E WEERI W+ EHRG R+++ MEYLKIAQDLEMYGVNY
Sbjct: 79 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
Query: 206 FEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAP 265
F I+NKKGTEL LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F IKP+DKK
Sbjct: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
Query: 266 DFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLEN 325
F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK +KQ+ER +L
Sbjct: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
Query: 326 EKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEE 385
EK+ RE AE+ ++ +ER ++ E E +++++ + KA ++E K ++
Sbjct: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
Query: 386 AERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEW 445
A E+E + + A A + ++ + EQ E K+A E +++ +EA +
Sbjct: 319 AAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEAEVLALKMA---EESERRAKEADQL 371
Query: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505
+ A+E + K++L + + P PP P+ P + + S + + +
Sbjct: 372 KQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDM 431
Query: 506 --MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENV-KAGRDKY 562
++ E+E+V +K++ +++QL L +E+ + + ++T D+LH EN + G K+
Sbjct: 432 KRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKH 491
Query: 563 KTLRQ 567
T+++
Sbjct: 492 NTIKK 496
Score = 29.6 bits (65), Expect = 8.0
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]
Length = 165
Score = 166 bits (421), Expect = 4e-41
Identities = 82/132 (62%), Positives = 98/132 (74%), Gaps = 1/132 (0%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
+KKV DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQAK 133
+VLLASYAVQAK
Sbjct: 138 SVLLASYAVQAK 149
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 155 bits (391), Expect = 1e-37
Identities = 117/484 (24%), Positives = 222/484 (45%), Gaps = 55/484 (11%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDV-K 71
D LE +QP ++L D V L+E +FG+ ++D G WL+L+ +V D+ K
Sbjct: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
Query: 72 KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQ 131
K P F +F+ E +S L + T LFFL K + +I ET LA++ +Q
Sbjct: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
Query: 132 AKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEY 191
GDY + + L P + L++H + E+R+ + + +G+ R ++++Y
Sbjct: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
Query: 192 LKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFN 251
+KI + L YGV+Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
Query: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILALCMGNHELYMRRRK-- 296
+KKF ++ D + +YA I K I + + H+ Y+ R++
Sbjct: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRKQSK 364
Query: 297 ---PDTIEVQQMKAQAREEKHQKQLERAQLE---------------NEKKKREIAEKEKE 338
P + ++ E Q+ + LE + + E++E++K
Sbjct: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQK- 423
Query: 339 RIEREK-EELMERLKQIEEQTIKAQKELEEQTRKALELDQER---------KRAKEEAER 388
REK EL ++ K ++E+ +K +EL++ + EL + ++ + R
Sbjct: 424 ---REKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR 480
Query: 389 LEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIA----LLEEAKKKKEEEATE 444
+ + + + A ++++ + +L E K+A L + KKK++++ T+
Sbjct: 481 VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD 540
Query: 445 WQHK 448
K
Sbjct: 541 AMKK 544
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 150 bits (380), Expect = 2e-36
Identities = 110/402 (27%), Positives = 187/402 (46%), Gaps = 39/402 (9%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDV-K 71
D +LE +QP K+L D V L+E +FG+ + D G+ WL+L+++V + D K
Sbjct: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88
Query: 72 KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQ 131
K P+ F +F+ E +S L T LFFL K I + I E LASY +Q
Sbjct: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147
Query: 132 AKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEY 191
GD++ L LP + L++H + E+R+ +++ G R +++ Y
Sbjct: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206
Query: 192 LKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFN 251
+ I + L YGV+Y+ +K+K+G WLG+ G+ Y++ DK+ P+ F W ++ N+ F
Sbjct: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266
Query: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILALCMGNHELYMRRR--K 296
+KKF ++ D + +YA I K I A+ + H+ Y+ R+ K
Sbjct: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325
Query: 297 PDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREI-----------AEKEKERIEREKE 345
+ + A + L+ ++L N K +I +E + + K+
Sbjct: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385
Query: 346 ELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAE 387
+++ LK Q+ LEE R+ LE + +K EAE
Sbjct: 386 DMLAALK-------SRQEALEETLRQRLE--ELKKLCLREAE 418
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 145 bits (366), Expect = 1e-34
Identities = 91/283 (32%), Positives = 145/283 (51%), Gaps = 18/283 (6%)
Query: 18 FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYST-WLKLNKKVTQQDVKKENPL 76
F + TG+ L D V +G+ E +FGLQ+ D S WL+ +K + +Q +K P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 QFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGD 136
FR +FF D + L QE T+ L+FLQ+K I + CP +AV+LASYAVQ+ +GD
Sbjct: 102 TLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 YNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQ 196
YN IH PGYL++ +P + E + ++++ HE+H G+ + ++ Y+ IA+
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212
Query: 197 DLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFV 256
L+ YGV ++ +L +G+ + G+ +Y K +PW I ISF KKF
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRKKFF 269
Query: 257 IKPIDKKAPD----FVFYAPRLRINKRILALCMGNHELYMRRR 295
I K+A F R K + C+ +H + ++
Sbjct: 270 IHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 145 bits (366), Expect = 1e-34
Identities = 91/283 (32%), Positives = 145/283 (51%), Gaps = 18/283 (6%)
Query: 18 FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYST-WLKLNKKVTQQDVKKENPL 76
F + TG+ L D V +G+ E +FGLQ+ D S WL+ +K + +Q +K P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 QFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGD 136
FR +FF D + L QE T+ L+FLQ+K I + CP +AV+LASYAVQ+ +GD
Sbjct: 102 TLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 YNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQ 196
YN IH PGYL++ +P + E + ++++ HE+H G+ + ++ Y+ IA+
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212
Query: 197 DLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFV 256
L+ YGV ++ +L +G+ + G+ +Y K +PW I ISF KKF
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRKKFF 269
Query: 257 IKPIDKKAPD----FVFYAPRLRINKRILALCMGNHELYMRRR 295
I K+A F R K + C+ +H + ++
Sbjct: 270 IHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 143 bits (360), Expect = 5e-34
Identities = 131/495 (26%), Positives = 217/495 (43%), Gaps = 35/495 (7%)
Query: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66
RVT +DA E E ++ + G+ LFD V + + L E +FGL + D+ WL +K++
Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
Query: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126
+Q + +P F F KF+P D ++ L ++IT+ LQ++ I+ + C T LL
Sbjct: 160 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Query: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
SYAVQA+ GDY+ E H Y++ R P + E EERI H+ +RGM +
Sbjct: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGE 268
Query: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIR 246
+ + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY ++ F W +I
Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 325
Query: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY-MRRRKPDTIE 301
IS+ F IK + F F P R KR+ +C+ +H + + +P
Sbjct: 326 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG 385
Query: 302 VQQMKAQAR-EEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
M ++ R + Q Q +A ++ ER ++ + L E
Sbjct: 386 FLVMGSKFRYSGRTQAQTRQASALIDRPAPFF-----ERSSSKRYTMSRSLDGAEFSRPA 440
Query: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
+ E + + D++ + + +E E E R + K +Q QE L
Sbjct: 441 SVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKP 500
Query: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
A + E K+ +E ++ H+ D E+ + + + P P P P
Sbjct: 501 EDVLLKHQASINELKRTLKEPNSKLIHR----DRDWERERR-----LPSSPASPSPKGTP 551
Query: 481 PTENEHDEHDENNAE 495
NE E + E
Sbjct: 552 EKANERAGLREGSEE 566
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 142 bits (357), Expect = 1e-33
Identities = 95/289 (32%), Positives = 149/289 (51%), Gaps = 19/289 (6%)
Query: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66
RVT +DA E E ++ + G+ LFD V + + L E +FGL + D+ WL +K++
Sbjct: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
Query: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126
+Q + +P F F KF+P D ++ L ++IT+ LQ++ I+ + C T LL
Sbjct: 98 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
Query: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
SYAVQA+ GDY+ E H Y++ R P + E EERI H+ +RGM +
Sbjct: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGE 206
Query: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIR 246
+ + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY ++ F W +I
Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 263
Query: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
IS+ F IK + F F P R KR+ +C+ +H +
Sbjct: 264 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 140 bits (353), Expect = 3e-33
Identities = 120/487 (24%), Positives = 210/487 (43%), Gaps = 42/487 (8%)
Query: 18 FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVD-SKGYSTWLKLNKKVTQQDVKKENPL 76
F + + G+ L D V K + L E +FGLQ D S WL NK + +Q +K+ +P
Sbjct: 43 FKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQ-LKRGSPY 101
Query: 77 QFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGD 136
FR KFF D ++ L +E T+ +FLQ+K+ IL + CP TA LLAS+AVQ++ GD
Sbjct: 102 SLNFRVKFFVSDPNK-LQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGD 160
Query: 137 YNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQ 196
Y++ + GYL++ +P + + +E+ I H++H G+ ++ YL A+
Sbjct: 161 YDQSENLSGYLSDYSFIPNQ--------PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212
Query: 197 DLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFV 256
LE+YGV + +++ E+ +GV + G+ IY++ ++ FPW +I ISF K+F
Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT---FPWLKIVKISFKCKQFF 269
Query: 257 I---KPIDKKAPDFV-FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREE 312
I K + + + F R K + C+ H + R +P +
Sbjct: 270 IQLRKELHESRETLLGFNMVNYRACKNLWKACV-EHHTFFRLDRPLPPQKNFFAHYFTLG 328
Query: 313 KHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERL-------------KQIEEQTI 359
+ R ++++ + +E A K++ + L +L ++E Q++
Sbjct: 329 SKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSL 388
Query: 360 KAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAA 419
++ + QE R + + + Q + +
Sbjct: 389 PSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVL 448
Query: 420 ELAEFT------AKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPP 473
E + AL + KK + H +Q+DLE E + S+P P
Sbjct: 449 ESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSH----SQQDLESHINETFDIPSSPEKP 504
Query: 474 PPPPVIP 480
P IP
Sbjct: 505 TPNGGIP 511
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 139 bits (350), Expect = 7e-33
Identities = 82/257 (31%), Positives = 147/257 (57%), Gaps = 16/257 (6%)
Query: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
K +++RV +D +E F I+P G+ L QV K + L E +FG+++ +++ Y WL+
Sbjct: 42 KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
K + +Q +++ + + KFFP D + L +E T+ LF LQ+K +L + + C T
Sbjct: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
A LL S+ +Q++ GDY++ + + N+ L Q QH L E+I +H++H G
Sbjct: 160 AALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQ----QHCL------EKILEFHQKHVG 209
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
+S + L+IA+ LEMYG+ + +++GT++ L V +G+ +++ K+ F
Sbjct: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
Query: 242 WSEIRNISFNDKKFVIK 258
WS++R +SF K+F+IK
Sbjct: 267 WSKVRKLSFKRKRFLIK 283
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 137 bits (345), Expect = 3e-32
Identities = 118/466 (25%), Positives = 215/466 (46%), Gaps = 33/466 (7%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72
D E ++ + G+ L +V + + L E +FGL D+ TWL K++ +Q +
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
Query: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
P F F KF+P D ++ L ++IT+ LQ+++ I+ + C T LL SY +Q+
Sbjct: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192
+ GDY+ E+H Y+++ +L P + TKE EE++ H+ +R M + +E+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQ-------TKE-LEEKVMELHKSYRSMTPAQADLEFL 178
Query: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252
+ A+ L MYGV+ + K+ +G ++ LGV + GL +Y+ DKL FPW ++ IS+
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKISYKR 235
Query: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
Query: 309 AREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQ 368
+ ++ + + ++ + ++ ER + R A +
Sbjct: 295 GSKFRYSGRTQ----AQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT 350
Query: 369 TRKALELDQ-------ERKRAKEEAERLEKERRAAEEAK-SAIAKQAADQMKNQEQLAAE 420
+ A+ Q + K + +KE AE K +QA + ++
Sbjct: 351 SAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKT 410
Query: 421 LAEFTAKIALLEEAKKKKEEEATE--WQHKAFAAQEDLEKTKEELK 464
E T + ++ +KK+E E + + EDL+K++EE+K
Sbjct: 411 HIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIK 456
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 137 bits (344), Expect = 4e-32
Identities = 110/408 (26%), Positives = 190/408 (46%), Gaps = 35/408 (8%)
Query: 2 PKPINVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
PK + +V +D +E ++ + G+ LFD+V + + L E +FGL Y D++ WL
Sbjct: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
Query: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
K++ +Q + F F KF+P D ++ L ++IT+ LQ+++ I++ + C
Sbjct: 167 PAKEIKKQ--VRSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
Query: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
T LL SY VQ++ GDY+ + Y++ R P TKE E+++ H+ HR
Sbjct: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNH-------TKEL-EDKVIELHKSHR 275
Query: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
GM ++ M +L+ A+ L MYGV+ K+ +G E+ LGV A GL IY ++ F
Sbjct: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
Query: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRK 296
W ++ IS+ F IK ++ F P R KR+ +C+ H + R
Sbjct: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV-EHHTFFRLLL 391
Query: 297 PDTIEVQQMKAQAR---EEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQ 353
P+ + + ++ + Q Q RA + ++ ER + +
Sbjct: 392 PEAPPKKFLTLGSKFRYSGRTQAQTRRAS--------ALIDRPAPYFERSSSKRYTMSRS 443
Query: 354 IEEQTIKAQKELEE---QTRKALELDQERKRAKEEAERLEKERRAAEE 398
++ + Q + QT + E K+A+EE + E +RR EE
Sbjct: 444 LDGEVGTGQYATTKGISQTNLITTVTPE-KKAEEERDEEEDKRRKGEE 490
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 137 bits (344), Expect = 4e-32
Identities = 127/465 (27%), Positives = 215/465 (46%), Gaps = 50/465 (10%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72
D E ++ + G+ L +V + + L E +FGL D+ TWL K++ +Q +
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
Query: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
P F F KF+P D ++ L ++IT+ LQ+++ I+ + C T LL SY +Q+
Sbjct: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192
+ GDY+ E+H Y+++ +L P + TKE EE++ H+ +R M + +E+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQ-------TKE-LEEKVMELHKSYRSMTPAQADLEFL 178
Query: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252
+ A+ L MYGV+ + K+ +G ++ LGV + GL +Y+ DKL FPW ++ IS+
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKISYKR 235
Query: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
Query: 309 AREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQ 368
+ ++ R Q + R+ L++R E+T A K
Sbjct: 295 GSKFRYS---GRTQAQT----------------RQASALIDRPAPHFERT--ASKRASRS 333
Query: 369 TRKALELDQ-ERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAK 427
A +D +R A + + + A A AK+ +E + AE+ +
Sbjct: 334 LDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEP 393
Query: 428 IALLE----EAKKKKEE----EATEWQHKAFAAQEDLEKTKEELK 464
E EA KKK E E +H EDL+K++EE+K
Sbjct: 394 PEQAEPEPTEAWKKKRERLDGENIYIRHSNLML-EDLDKSQEEIK 437
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 136 bits (343), Expect = 5e-32
Identities = 98/378 (25%), Positives = 189/378 (50%), Gaps = 25/378 (6%)
Query: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
K +++++ +D E F + GK L D V + L E +FGL++ D K + WL L
Sbjct: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
Query: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
K + +Q +++ + KF KFFP D ++ L +E+T+ LF LQVK+ + + C +
Sbjct: 98 LKPIVKQ-IRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
Query: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
A LL S+ VQ++ GD+++ + + +LA ++ +PQ+ + E++I +H H G
Sbjct: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
Query: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
+S + L+IA+ LEMYG+ K+++GT++ L V G+ +++ K+ F
Sbjct: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
Query: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297
W+++R +SF K+F+IK P A F K +C+ +H + +P
Sbjct: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
Query: 298 DTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQ 357
+ ++ + + ++ L+ K+ +K + ER K + ++ + Q
Sbjct: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE----GGHKKVQFER-KHSKIHSIRSLASQ 377
Query: 358 TIKAQKELEEQTRKALEL 375
+ E+ EQ++++ L
Sbjct: 378 PTELNSEVLEQSQQSTSL 395
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 135 bits (339), Expect = 1e-31
Identities = 98/295 (33%), Positives = 151/295 (51%), Gaps = 21/295 (7%)
Query: 16 LEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGY---STWLKLNKKVTQQDVKK 72
LE T K +FD VV +GL E F L + Y LKL K V + K+
Sbjct: 584 LELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTK-VAPEGWKE 642
Query: 73 ENPLQFK--------FRAKFFPEDVSEELIQE-ITQRLFFLQVKEAILNDEIYCPPETAV 123
E + K FR KFF +DVS LIQ +T ++LQ+++ IL + ++C ET++
Sbjct: 643 EPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDETSL 700
Query: 124 LLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGML 183
LLAS A+QA+YGDY E+H Y + LP RV+E KL +E + H + G
Sbjct: 701 LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVME--KLDLSYIKEELPKLHNTYVGAS 758
Query: 184 REDSMMEYLKIAQDLEMYGVNYFEI--KNKKGTELWLGVDALGLNIYE-HDDKLTPKIGF 240
+++ +E+LK+ Q L YGV++ + + K T + LGV + G+ ++E H+ T + F
Sbjct: 759 EKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
PW E + ISF+ KK ++ F +I + +L LC H+ ++ R
Sbjct: 819 PWRETKKISFSKKKITLQN-TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR 872
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 135 bits (339), Expect = 1e-31
Identities = 98/295 (33%), Positives = 151/295 (51%), Gaps = 21/295 (7%)
Query: 16 LEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGY---STWLKLNKKVTQQDVKK 72
LE T K +FD VV +GL E F L + Y LKL K V + K+
Sbjct: 584 LELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTK-VAPEGWKE 642
Query: 73 ENPLQFK--------FRAKFFPEDVSEELIQE-ITQRLFFLQVKEAILNDEIYCPPETAV 123
E + K FR KFF +DVS LIQ +T ++LQ+++ IL + ++C ET++
Sbjct: 643 EPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDETSL 700
Query: 124 LLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGML 183
LLAS A+QA+YGDY E+H Y + LP RV+E KL +E + H + G
Sbjct: 701 LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVME--KLDLSYIKEELPKLHNTYVGAS 758
Query: 184 REDSMMEYLKIAQDLEMYGVNYFEI--KNKKGTELWLGVDALGLNIYE-HDDKLTPKIGF 240
+++ +E+LK+ Q L YGV++ + + K T + LGV + G+ ++E H+ T + F
Sbjct: 759 EKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
PW E + ISF+ KK ++ F +I + +L LC H+ ++ R
Sbjct: 819 PWRETKKISFSKKKITLQN-TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR 872
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 135 bits (339), Expect = 1e-31
Identities = 98/295 (33%), Positives = 151/295 (51%), Gaps = 21/295 (7%)
Query: 16 LEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGY---STWLKLNKKVTQQDVKK 72
LE T K +FD VV +GL E F L + Y LKL K V + K+
Sbjct: 584 LELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTK-VAPEGWKE 642
Query: 73 ENPLQFK--------FRAKFFPEDVSEELIQE-ITQRLFFLQVKEAILNDEIYCPPETAV 123
E + K FR KFF +DVS LIQ +T ++LQ+++ IL + ++C ET++
Sbjct: 643 EPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDETSL 700
Query: 124 LLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGML 183
LLAS A+QA+YGDY E+H Y + LP RV+E KL +E + H + G
Sbjct: 701 LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVME--KLDLSYIKEELPKLHNTYVGAS 758
Query: 184 REDSMMEYLKIAQDLEMYGVNYFEI--KNKKGTELWLGVDALGLNIYE-HDDKLTPKIGF 240
+++ +E+LK+ Q L YGV++ + + K T + LGV + G+ ++E H+ T + F
Sbjct: 759 EKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
PW E + ISF+ KK ++ F +I + +L LC H+ ++ R
Sbjct: 819 PWRETKKISFSKKKITLQN-TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR 872
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 135 bits (339), Expect = 1e-31
Identities = 98/295 (33%), Positives = 151/295 (51%), Gaps = 21/295 (7%)
Query: 16 LEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGY---STWLKLNKKVTQQDVKK 72
LE T K +FD VV +GL E F L + Y LKL K V + K+
Sbjct: 584 LELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTK-VAPEGWKE 642
Query: 73 ENPLQFK--------FRAKFFPEDVSEELIQE-ITQRLFFLQVKEAILNDEIYCPPETAV 123
E + K FR KFF +DVS LIQ +T ++LQ+++ IL + ++C ET++
Sbjct: 643 EPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDETSL 700
Query: 124 LLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGML 183
LLAS A+QA+YGDY E+H Y + LP RV+E KL +E + H + G
Sbjct: 701 LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVME--KLDLSYIKEELPKLHNTYVGAS 758
Query: 184 REDSMMEYLKIAQDLEMYGVNYFEI--KNKKGTELWLGVDALGLNIYE-HDDKLTPKIGF 240
+++ +E+LK+ Q L YGV++ + + K T + LGV + G+ ++E H+ T + F
Sbjct: 759 EKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
PW E + ISF+ KK ++ F +I + +L LC H+ ++ R
Sbjct: 819 PWRETKKISFSKKKITLQN-TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR 872
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 132 bits (332), Expect = 9e-31
Identities = 81/277 (29%), Positives = 141/277 (50%), Gaps = 15/277 (5%)
Query: 20 IQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQD--VKKENPLQ 77
I+ +T G + D V V L E+ +FGL+Y D + WL K + + + P
Sbjct: 32 IKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYT 91
Query: 78 FKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDY 137
F KF+ ED + L +EIT+ FFLQVK+ +L + CP TA L +YA+Q++ GDY
Sbjct: 92 LYFGIKFYAEDPCK-LKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDY 150
Query: 138 NKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQD 197
+ H GY++ R +P + KE+ EE I+ H+ G + ++ + YL+ A+
Sbjct: 151 DPYKHTAGYVSEYRFVPDQ--------KEELEEAIERIHKTLMGQIPSEAELNYLRTAKS 202
Query: 198 LEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVI 257
LEMYGV+ + + +E +LG+ +G+ +Y++ ++ + W I + F + +F +
Sbjct: 203 LEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGK---YFWPRITKVHFKETQFEL 259
Query: 258 KPIDKKAPD-FVFYAPRLRINKRILALCMGNHELYMR 293
+ + K + F+ R + + L C H + R
Sbjct: 260 RVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFR 296
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,595,582
Number of Sequences: 37866
Number of extensions: 1167595
Number of successful extensions: 47888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1308
Number of HSP's successfully gapped in prelim test: 1346
Number of HSP's that attempted gapping in prelim test: 13170
Number of HSP's gapped (non-prelim): 15376
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.